Genetic Association of Glucocorticoid Receptor Gene Polymorphisms With Binge Eating

Study Overview
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Brief Summary
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The aim of the present study was to specifically screen obese diabetic adolescent female individuals for BED, checking the variants of the GR gene (rs56149945; rs41423247) amongst identified individuals, and this led to assessing the impact of binge eating disorders on glycaemic control in obese diabetic adolescent females in Pakistan, South Asia.

Detailed Description
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Challenges in eating for diabetic adolescents can be categorized as eating disorders (ED) and disordered eating symptoms (DES). Binge-eating disorder (BED) is defined as recurrent episodes of binge eating at least once a week over a three-month time period and it is accompanied by feeling the lack of control and marked distress over one's eating behaviour. The aim of the present study was to specifically screen obese diabetic adolescent female individuals for BED, checking the variants of the GR gene (rs56149945; rs41423247) amongst identified individuals, and this led to assessing the impact of binge eating disorders on glycaemic control in obese diabetic adolescent females in Pakistan, South Asia.

Official Title
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Genetic Association of Glucocorticoid Receptor Gene Polymorphisms With Binge Eating Disorders in Type 2 Diabetic Obese Female Adolescents

Conditions
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Binge-Eating Disorder, Eating Disorders, Obesity, Diabetes Type 2, Adolescent Behavior

Intervention / Treatment
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* Diagnostic Test: BED Questionnaire


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Unmarried females diagnosed with Type 2 diabetes > 12 months Age 10-19 years Obesity class I and II (based on BMI range of 30 - 40). Exclusion Criteria: Presence of psychosis, major psychiatric or neurocognitive disorder Substance use Untreated attention-deficit hyperactivity disorder Use of psychopharmacological medications or psychotherapy Class III obesity

Ages Eligible for Study
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Minimum Age: 10 Years
Maximum Age: 19 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Screening
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Group BED<br>Those who are diagnosed with having Binge Eating disorder. These individuals qualified after the questionnaire was administered. | Diagnostic Test: BED Questionnaire<br>* BED Questionnaire<br>|
| No Intervention: Group Non-BED<br>Those who are not diagnosed with having Binge Eating disorder | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| BED | Presence of BED detected by individuals who score high on the BEDS7 Questionnaire administered | Baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| NR3C1 Presence of variants of the GR gene (rs56149945; rs41423247) | Presence of variants of the GR gene (rs56149945; rs41423247) | Six months into the study after identifying all individuals who scored high on the BEDS7 Questionnaire |