Objective Markers of Pain Perception in Humans

Study Overview
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Brief Summary
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Determine objective markers of pain perception remains a major scientific and medical issue. Various tools have been proposed to objectify pain, but their adaptability to different clinical contexts are limited. Our working hypothesis considers that the research for markers of immediate pain perception should be based on an electrophysiological approach, based on the combined analysis of EEG and autonomic responses.

Detailed Description
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This project aims to study the cortical and autonomic responses induced by tonic painful stimulation compared to those induced by comparable sensory and stressful stimulations, by combining high density EEG, cutaneous sympathetic, cardiovascular and pupillary recordings.

Official Title
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Objective Markers of Pain Perception in Humans: a Study in Healthy Subjects

Conditions
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Healthy

Intervention / Treatment
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* Other: Painful tonic stimuli
* Other: non-painful stimuli


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Affiliate or beneficiary of social security Signature of consent Exclusion Criteria: History of cardiovascular disease (vagal syncope, hypertension, etc ...), renal, metabolic (diabetes ...), psychiatric (depression, etc ...) or neurological (seizure, etc ...) syndromes; Reynaud's syndrome; Raynaud's disease; Acrocyanosis; Known rhythm disorders; Participation at the same time in another clinical trial; Taking a medical treatment; Suffering from acute (complaint of pain in the week before the test) or chronic pain, Allergic to conductive gel for electrodes.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: EEG responses<br>The study compares electroencephalographical responses (EEG) to painful stimuli tonic to those evoked by non-painful stimuli and with or without virtual reality | Other: Painful tonic stimuli<br> <br> Other: non-painful stimuli<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| EEG Gamma power. | The EGG signals are compared between a painful stimuli tonic to those evoked by non-painful stimuli. | Baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| ratio of low to high frequency spectral powers | The low and high frequency spectral powers are measured by an ECG Holter. The ratio are compared between a painful stimuli tonic to those evoked by non-painful stimuli. | Baseline | 
| Magnitude of the sympathetic cutaneous reactivity | The sympathetic cutaneous reactivity is measured by an acquisition system (ME6000, MEDIMEX, France) with one electrode on the hand. The magnitudes are compared between a painful stimuli tonic to those evoked by non-painful stimuli. | Baseline | 
| Amplitude of pupillary dilation | The pupillary dilation is measured by the ISCAN® system (MA, USA). The amplitudes are compared between a painful stimuli tonic to those evoked by non-painful stimuli. | Baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Healthy Volunteers, Pain, EEG