RegisterNET - A Registry for Neuroendocrine Tumors in the USA

Study Overview
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Brief Summary
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Neuroendocrine tumors are derived from the neuroendocrine system of the gastroenteropancreatic and bronchopulmonary tract systems. Treatment options include surgery, medical and ablative therapies as well as peptide-receptor radionuclide therapy. Survival is linked to early and accurate diagnoses or to the effective detection of disease recurrence and/or treatment failure. One challenge is to develop accurate non-invasive blood tests that can detect neuroendocrine tumor activity. A second challenge is to evaluate the effectiveness of molecular biomarkers in the natural history of this disease. RegisterNET registry aims at collecting data and blood samples from patients presenting with a NET in the USA. Data will be entered prospectively and anonymized after informed consent. All physicians who treat neuroendocrine tumor patients are invited to participate to the registry. Data will be evaluated within regular time frames, focusing on diagnostic accuracy for biomarkers in the different types and grades of tumors, treatment modalities and patient outcomes (e.g. disease recurrence and survival), thereby contributing to an understanding of the role of biomarkers in tumor management.

Detailed Description
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Background: Survival for neuroendocrine tumors is linked to early and accurate diagnoses or to the effective detection of disease recurrence and/or treatment failure. Non-invasive biomarkers have been identified that can improve diagnosis and prognosis of patients. Little, however, is known about the utility of these markers in clinical practice. Objective: To systematically and prospectively collect clinical information and blood samples from neuroendocrine tumors in the USA based a histologically confirmed diagnosis. Methods: All neuroendocrine tumors (gastroenteropancreatic and pulmonary) are following informed consent. Data will be entered prospectively and anonymized. Patient history including a quality of life survey are completed by contributing physicians and blood sample is collected for analysis. All information will be transferred to the database. Evaluation of treatment modalities and patient outcomes (e.g. disease recurrence) will be assessed at follow-up times. The primary objectives of the project are to: monitor patients with neuroendocrine tumors provide descriptive statistical analyses assessment of diagnostic accuracy of molecular-based blood tests The secondary objectives of the project include: assessment of disease recurrence analysis of patient survival Analyses will include: Descriptive statistical analyses including demographics, site, treatment, QoL assessment. Clinical follow-up and blood chemistry results. Correlation analyses between blood results and clinical data. This will include assessment of the time at which the blood chemistry results significantly (and consistently) increases and the time of tumor recurrence and an evaluation whether the change in blood results is predictive of disease recurrence.

Official Title
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A Registry for Neuroendocrine Tumors in the USA

Conditions
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Carcinoid, Neuroendocrine Tumor, Neuroendocrine Carcinoma

Intervention / Treatment
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* Device: NETest


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Gastroenteropancreatic neuroendocrine tumor Bronchopulmonary neuroendocrine tumor Gastroenteropancreatic neuroendocrine carcinoma Patient provides informed consent Exclusion Criteria: N/A

Ages Eligible for Study
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Minimum Age: 21 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: NETest|Non-invasive blood test|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Tumor-related recurrence | Image-based identification of recurrent tumor disease | 5 years | 
| Tumor-related diagnosis | Histological confirmation of neuroendocrine tumor | 1 year | 
| Tumor-related mortality | Survival from disease | 10 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quality of Life Evaluation | Questionnaire to evaluate quality of life status | 5 years | 
| Biomarker prediction of treatment response and disease relapse | Biomarker prediction of treatment response and disease relapse | 10 years |