Predictive Values of Serum Adiponectin Levels in Aneurysmal Subarachnoid Hemorrhage.

Study Overview
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Brief Summary
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The purpose of this study is to evaluate the predictive value of serum adiponectin levels in aneurysmal subarachnoid hemorrhage patients.

Detailed Description
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Adiponectin (APN) is an abundant protein hormone derived from adipose tissue. It has been suggested to exert anti-inflammatory, antiatherogenic, and vascular protective. Subarachnoid hemorrhage (SAH) comprises about 5% of all strokes with high mortality and permanent disability rates. Although many patients survive from the initial hemorrhage or rebleeding, they suffered from long-term delayed neurological deficits (DNDs), including stroke, delayed cerebral ischemia, cognitive and neuropsychological abnormalities that seriously impact overall function and quality of life. Ruptured cerebral aneurysms are the most common cause of SAH. There is growing evidence supporting APN act as a predictive factor for SAH. The observational study will focus on the predictive value of serum adiponectin levels in aneurysmal subarachnoid hemorrhage (aSAH).

Official Title
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Predictive Values of Serum Adiponectin Levels in Aneurysmal Subarachnoid Hemorrhage.

Conditions
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Subarachnoid Hemorrhage, Aneurysmal

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age>18yrs and age<90yrs It shows subarachnoid hemorrhage (SAH) based on computed tomography (CT) scan on admission Aneurysmal subarachnoid hemorrhage confirmed by computed tomography angiography (CTA), magnetic resonance angiography (MRA) or digital subtraction angiography (DSA) SAH grade is assessed by Hunt & Hess classification Informed consented Exclusion Criteria: Traumatic subarachnoid hemorrhage Patients with cerebral herniation or highly possible to occur within 2 days from SAH Length of hospital stay is expected to be less than 5 days Duration from onset to admission is more than 48 hours Disturbance of communication or poor compliance to blood collection, imaging examination and follow-up

Ages Eligible for Study
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Minimum Age: 16 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of cerebral vasospasm and delayed cerebral ischemia | Proved by clinical and radiologic evidence | 30 days post SAH | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Death |  | 30 days post SAH | 
| National institutes of health stroke scale (NIHSS) score | Assessing by senior neurosurgeons | On discharge or 14 days (whichever occurs first) and 30 days post SAH | 
| Modified Rankin scale (mRS) | By phone call following-up | 30 days and 90days post SAH | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Subarachnoid Hemorrhage, Aneurysmal, Predictive, Adiponectin