Postoperative Anemia and Functional Outcomes After Fast-track Primary Hip Arthroplasty

Study Overview
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Brief Summary
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The purpose of this study is to evaluate the possible association between postoperative anaemia and functional outcomes the first 2 weeks after primary hip arthroplasty. The investigators hypothesise that patients with a higher degree of postoperative anaemia have impaired postoperative rehabilitation as measured by standardized functional outcome tests.

Detailed Description
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Postoperative anemia may impair postoperative rehabilitation due to anemia related symptoms such as fatigue or dizziness. Although, the impact of postoperative anemia on postoperative rehabilitation and function has previously been examined the results are conflicting. Patients undergoing fast-track hip arthroplasty (THA) are mobilized early and participate in physiotherapy during the admission but are discharged early (2-3) days postoperative. However, the ability to rehabilitate early after discharge has not been evaluated in relation to postoperative anemia. The purpose of this observational study is to evaluate the possible association between postoperative anaemia and functional outcomes the first 2 weeks after primary hip arthroplasty. The investigators hypothesise that patients with a higher degree of postoperative anaemia have impaired postoperative rehabilitation as measured by standardized functional outcome tests. Hb concentrations and functional outcome measurements will be performed preoperatively, at the day of hospital discharge and during a postoperative visit 12-16 days after surgery.

Official Title
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Postoperative Anemia and Functional Outcomes After Fast-track Primary Hip Arthroplasty - a Prospective Observational Study

Conditions
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Arthroplasty, Hip Replacement, Anemia

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients undergoing primary unilateral THA Age 65 or older Exclusion Criteria: Not able to give consent Not able to walk prior to surgery Chronic need for RBC transfusion

Ages Eligible for Study
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Minimum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Study Cohort<br>Patients, aged 65 or above, undergoing elective primary unilateral hip arthroplasty in a fast-track setting. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 6 Minute walking test (6MWT) | 6MWT is a standardized functional test which determines the walking distance covered during a timed period of 6 minutes. | 2 weeks after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| FACT-Anemia Scale | FACT-Anemia scale is a validated questionare based score addressing anaemia related symptoms. | 2 weeks after surgery | 
| Timed up and go test (TUG) |  | 2 weeks after surgery | 
| At home activity by ActivPal | Activity measures using accelerometer based activity monitor | 1 week after surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Primary hip arthroplasty, postoperative anemia, functional outcomes