Effect of Intake of Citron(Citrus Junos Siebold ex Tanaka) Peel Extract on Blood Cholesterol.

Study Overview
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Brief Summary
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This study was conducted to investigate the effects of daily supplementation of Citron(Citrus Junos Siebold ex Tanaka) Peel Extract on improvement of Blood Cholesterol.

Detailed Description
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This study was a 12 weeks, randomized, double-blind, placebo-controlled human trial. Twenty subjects were randomly divided into Citron(Citrus Junos Siebold ex Tanaka) Peel Extract or a placebo group. Blood cholesterol profiles before and after the intervention.

Official Title
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A 12-week, Randomized, Double-blind, Placebo-controlled Human Trial to Evaluate the Efficacy and Safety of Citron(Citrus Junos Siebold ex Tanaka) Peel Extract on Improvement of Blood Cholesterol

Conditions
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Hyperlipidemia

Intervention / Treatment
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* Dietary Supplement: Citron peel extract
* Dietary Supplement: Placebo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 19-75 years with Total cholesterol 200-239 mg/dL Exclusion Criteria: Lipid lowering agent within past 6 months Severe cardiovascular disease(Mvodardial infarction, stroke, etc) Renal disease(Heredity hyperlipidemia, Acute/Chronic renal failure, Nephrotic syndrome, ect) Cancer, Respiratory organ disease(Asthma, Chronic obstructive pulmonary disease) Diabetes mellitus Allergic or hypersensitive to any of the ingredients in the test products History of disease that could interfere with the test products or impede their absorption Under antipsychotic drugs therapy within past 2 months History of alcohol or substance abuse Participation in any other clinical trials within past 2 months Laboratory test by show the following results Pregnancy or breast feeding Not Contraception(except: Surgery for female infertility)

Ages Eligible for Study
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Minimum Age: 19 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Citron peel Extract<br>Citron peel extract for 12 weeks | Dietary Supplement: Citron peel extract<br>* Citron peel extract for 12 weeks<br>|
| Placebo Comparator: Placebo<br>Placebo for 12 weeks | Dietary Supplement: Placebo<br>* Placebo for 12 weeks<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes of Cholesterol | Changes of Cholesterol were assessed before and after the intervention | 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes of Lipid profile | Changes of Lipid profile were assessed before and after the intervention | 12 weeks | 
| Changes of Oxidized LDL | Changes of Oxidized LDL were assessed before and after the intervention | 12 weeks |