A Change in Diet May Decrease the Negative Consequences of Chronic Sleep Deprivation

Study Overview
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Brief Summary
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The purpose of this study is to determine whether or not a low calorie, low glycemic index diet with omega-3 fatty acid supplements can prevent some of the negative consequences of sleep deprivation.

Detailed Description
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This pilot study included 18 medical residents at two academic medical centers in New York City. All residents who participated in the study were assigned to work a night shift schedule for two weeks, and began the study on the morning prior to their first evening shift. The study subjects were randomly assigned to one of two groups: Intervention diet -- consisting of 40% carbohydrates, 30% protein, and 30% fat with 2.4g of long chain fatty acid supplements (n=9) Total calories for males was 1600/day, and 1200/day for females Control group -- ad lib diet. Main outcome measures included: weight resting metabolic rate percent body fat lipid profile CRP fasting glucose and insulin levels urinary neurotransmitter levels salivary cortisol six cognitive tests of memory, attention, and executive function. Subjects were tested on day 1, 7, and 14 of the study.

Official Title
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Pilot Study: A Dietary Intervention May Decrease the Negative Metabolic and Cognitive Consequences of Chronic Sleep Deprivation

Conditions
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Sleep Deprivation

Intervention / Treatment
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* Drug: Controlled Dietary Intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Medical resident in good standing at Cabrini Medical Center or Saint Vincent's Hospital, NY. Must be scheduled for two consecutive weeks of night shift work. Exclusion Criteria: Febrile illness Smoker Food allergies of any kind Taking any prescription medication History of diabetes or thyroid dysfunction Body mass index (BMI)>30 Pregnancy

Ages Eligible for Study
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Minimum Age: 25 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Controlled Dietary Intervention|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Resting Metabolic Rate |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Weight |  |  | 
| Percent Body Fat |  |  | 
| Waist Circumference |  |  | 
| Lipid Profile |  |  | 
| C-reactive Protein Levels |  |  | 
| Fasting serum glucose |  |  | 
| Fasting serum insulin |  |  | 
| Urinary neurotransmitter levels |  |  | 
| Salivary a.m. cortisol levels |  |  | 
| Cognitive scores on: Stroop Test, Hopkins Verbal Learning Test, Trail Making Test, Digit Span, Block Design, Dynamic Visual Acuity, Short Form 36 |  |  | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Diet, Chronic sleep deprivation, Weight, Cognitive impairment, Lipids, Inflammation, Resting metabolic rate, Weight Gain, Percent Body Fat, Hyperlipidemia