Live Birth Rate in Patients With Unexplained Recurrent Pregnancy Loss

Study Overview
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Brief Summary
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STUDY AIM: to study the pregnancy outcomes and offspring development of patient with Unexplained Recurrent Pregnancy Loss Treated by PGS and spontaneous pregnancy, and to compare the health economic indicators and patient satisfaction of the two modes of pregnancy, so as to better guide the clinical treatment.

Detailed Description
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400 patients with two times or more unexplained pregnancy loss, who wants to be pregnant via preimplantation genetic screening procedure or spontaneous pregnancy are intended to be enrolled. They are going to divided into two groups: PGS(preimplantation genetic screening) group and SP(spontaneous pregnancy) group. The pregnancy outcomes and offspring development of those patients will be followed up by our investigators.

Official Title
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Comparing the Live Birth Rate of Preimplantation Genetic Screening Versus Spontaneous Pregnancy in Patients With Unexplained Recurrent Pregnancy Loss

Conditions
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Recurrent Pregnancy Loss, Preimplantation Genetic Screening

Intervention / Treatment
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* Procedure: Preimplantation Genetic Screening(exposure)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients with two times or more unexplained pregnancy loss(less than 24 weeks of gestational age, biochemical pregnancy excluded), who wants to be pregnant via preimplantation genetic screening procedure or spontaneous pregnancy. Exclusion Criteria: anatomic abnormality of the reproductive system; endocrine metabolic disease; autoimmune related disease; chromosomal abnormalities; hydrosalpinx; cervical insufficiency.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| PGS(Preimplantation Genetic Screening)<br>patients with two times or more unexplained pregnancy loss, who wants to be pregnant via preimplantation genetic screening procedure | Procedure: Preimplantation Genetic Screening(exposure)<br>* Preimplantation genetic screening (PGS) was developed in the late 1980s as an alternative to prenatal diagnosis for couples at risk of transmitting a genetic or chromosomal abnormality to their children. In embryos created through in vitro fertilisation (IVF), cells are biopsied and analysed using genetic tests such as polymerase chain reaction and fluorescent in situ hybridisation (FISH).<br>|
| SP(spontaneous pregnancy )<br>patients with two times or more unexplained pregnancy loss, who wants to be pregnant via spontaneous pregnancy. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Live birth rate | the rate of the birth of a living fetus | 2 years of following up | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Unexplained Recurrent Pregnancy Loss, Preimplantation Genetic Screening, spontaneous pregnancy