Short-term Effects of Tai Chi Chuan Exercise on the Regulation of Lipid and Glucose Metabolisms and Endothelial Function

Study Overview
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Brief Summary
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The short term effects of TCC exercise are the significant increase in serum insulin and insulin resistance, and the significant decrease in serum TC, HDL-C, ET-1 and insulin sensitivity in TCC practitioners. TCC might be benefit the health of its practitioners through the regulation of lipid and glucose metabolism and endothelial function.

Detailed Description
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Tai Chi Chuan (TCC) has been shown to be beneficial to the health. However, its effects on lipid and glucose metabolism are not fully understood. This study investigated the short term effect of TCC exercise on lipid and glucose metabolism and endothelial function in TCC practitioners. Twenty-one TCC practitioners and nineteen normal controls were included in this study. The hemodynamics, serum insulin, indices of insulin resistance/sensitivity, serum endothelin-1 (ET-1), blood lipids and aldosterone before and 30 min after a rest or a session of classical Yang's TCC exercise were compared.

Official Title
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The Effect of Tai Chi Chuan on the Endothelin, Insulin, Blood Lipid, Blood Sugar, Aldosterone and Hemodynamics in the Elderly Adults

Conditions
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Physiological Effect of TCC on Glucose Metabolism

Intervention / Treatment
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* Behavioral: Classical Yang's TCC exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: TCC practitioners in a TCC training center in Taiwan over 50 years of age Healthy subjects without TCC experience over 50 years of age Exclusion Criteria: Subjects who had major cardiopulmonary disease Subjects who have diabetes mellitus, renal or liver disease
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Health Services Research
Intervention Model: Single Group Assignment
Interventional Model Description: Twenty-one TCC practitioners and nineteen normal controls were included in this study. The hemodynamics, serum insulin, indices of insulin resistance/sensitivity, serum endothelin-1 (ET-1), blood lipids and aldosterone before and 30 min after a rest or a session of classical Yang's TCC exercise were compared.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: TCC group<br>Classical Yang's TCC exercise | Behavioral: Classical Yang's TCC exercise<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change in quantitative insulin sensitivity check index | change in insulin sensitivity due to TCC | before and 30 minutes after the completion of TCC exercise | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change in serum total cholesterol | change in serum total cholesterol due to TCC | before and 30 minutes after the completion of TCC exercise | 
| change in homeostasis model assessment-estimated insulin resistance | change in insulin resistance by TCC | before and 30 minutes after the completion of TCC exercise | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Tai Chi Chuan, insulin resistance, cholesterol, endothelin-1