A Registry Study on Hospitalized Patients With Community-acquired Pneumonia in Real-life of China

Study Overview
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Brief Summary
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The purpose of this study is to evaluate the disease burden of hospitalized patients with CAP and HCAP in real life of China

Detailed Description
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In China, the data about current management of patients hospitalized with community acquired pneumonia (CAP) in the real-life setting is not available,type of pneumonia, selection of initial antibiotic, time to clinical stability, antibiotic choice anf modification,clinical outcomes and costs remain unclear. In this study, we will collect comprehensive information on CAP and healthcare associated pneumonia (HCAP) management patterns to evaluate the disease burden of hospitalized patients with CAP and HCAP in real life of China .to analyze microbiological characteristics,clinical manifestations,antibiotic regimens ,adherences to guidelines and effect on outcome in different groups of patients with CAP (> and = 65 years, different comorbidities ,risk factors) ,to investigate microbiological characteristics,clinical manifestations,antibiotic regimens ,adherences to guidelines and effect on outcome in different groups of disease severity with CAP ,to provide the difference on microbiological characteristics,clinical manifestations,antibiotic regimens ,and outcome between patients with CAP and HCAP ,to understand the current situation of antibiotic regimen ,to evaluate influence of different antibiotic regimens on prognosis.

Official Title
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Evaluating the Adherence to Guidelines' Empirical Antibiotic Recommendations and Outcome of Patients Admitted to a Hospital Ward With a Diagnosis of Community-acquired Pneumonia

Conditions
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Community Acquired Pneumonia

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients > or = 14 years of age Patient meets the criteria of community acquired pneumonia Patient meets the criteria of healthcare-associated pneumonia Informed consent to participate in the study is provided Exclusion Criteria: Patients participating in a clinical trial or other intervention studies Patients <14 years of age Patient meets the criteria of hospital acquired pneumonia Known active tuberculosis or current treatment for tuberculosis Non-infectious pulmonary diseases （e.g. pulmonary embolism, pulmonary edema, pulmonary vasculitis, interstitial pneumonia） HIV positive

Ages Eligible for Study
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Minimum Age: 14 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| initial antibiotic treatment failure rate | a change in antibiotic therapy due to worsening signs or symptoms of infection or lack of clinical improvement after first dose use of antibiotics to 72h | 72 hours | 
| in-hospital clinical failure rate | 1)a change in antibiotic therapy due to worsening signs or symptoms of infection or lack of clinical improvement, 2) in-hospital mortality, 3) recurrence, defined as signs or symptoms of infection after completion of therapy requiring re-initiation of antibiotics | Time from date of admission to discharge up to 1 week | 
| 30-day post-discharge clinical failure rate | rate of re-hospitalization due to pulmonary infection and death during the follow-up period at 30 days post-discharge from hospital | discharge up to 5 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Duration of intravenous antimicrobial therapy | Time from the first dose of intravenous antibiotics to date of stop of intravenous antibiotics ,participants will be followed for the duration of hospital stay | 2 weeks | 
| Duration of oral antimicrobial therapy | Time from date of administration of first antibiotic to date of discontinuation of last antibiotic | 2 weeks | 
| Duration of antimicrobial therapy | Time from date of administration of first antibiotic to date of discontinuation of last antibiotic (or to date of censoring, whichever comes first) upto a maximum of 30 days post-discharge from hospital post discharge from hospital | 6 weeks | 
| Days of each antimicrobial therapy | Time from date of first administration on admission to hospital to date of discontinuation (or to date of censoring, whichever comes first) upto a maximum of 30 days post-discharge follow-up for each antibiotic | 6 weeks | 
| Hospital length of stay | Patients will be asked about hospitalization, date, Patients will be asked about hospitalization, date, participants will be asked about the time of admission and discharge | 2 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Community Acquired Pneumonia, Healthcare Associated Pneumonia