Pethidine Analgesia on Labor Duration

Study Overview
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Brief Summary
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Although opioid analgesics are used to treat labor pain, there are still concerns about their side effects. The researchers in this study; aimed to evaluate the effect of pethidine on active phase duration of labor, labor pain and maternal-neonatal. 50 mg pethidine will be administered intramuscularly to the cases to be included in the study group. The patients in the control group will be given placebo injections. Vital signs of all cases included in the study will be checked at 0, 5, 15, 30, 45 and 60 minutes. Pain will also be assessed by Visual Analogue Scale (VAS) before injection and at the 1st and 2nd hour after injection. Delivery times, maternal side effects, neonatal apgar scores and fetal findings will be recorded.

Official Title
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The Effect of Pethidine Analgesia on Labor Duration and Maternal-Fetal Outcomes

Conditions
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Labor Pain

Intervention / Treatment
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* Drug: pethidine
* Drug: Placebo - Concentrate


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: nullipar-multiparous patients; singleton pregnancies 37- 41 weeks (by the last menstrual period). Exclusion Criteria: maternal respiratory rate < 8 /min, maternal bradycardia (<60 bpm), major fetal congenital anomalies, uterine scar presence from previous pregnancies, malpresentation, antepartum hemorrhage, multiple pregnancy, labor induction, chronic systemic disease, rupture fetal membranes, epidural analgesia.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Pethidine group / study group<br>Study group; patients given pethidine; The partogram was recorded during delivery. Cervical examination was performed at 2 hour intervals. Recorded in the file. 4 cm and greater cervical dilatation; 50 mg intramuscular (IM) injection was given to pethidine. 200 Montevideo units uterine contractions were reached. Maternal vital signs, maternal complications and neonatal APGAR scores were recorded by the clinician 0-5-15-30-45-60 minutes after pethidine injection. | Drug: pethidine<br>* Pethidine 50 mg intramuscular (IM) injection was performed when cervical dilatation was at or greater than 4 cm and the cardiotocogram uterine contraction recordings of 200 Montevideo units was reached. Opioid analgesia (pethidine HCl - 50 mg I.M.) was given following amniotomy.<br>|
| control group<br>The patients who received placebo injection were included in the control group. Saline was given in placebo. | Drug: Placebo - Concentrate<br>* Intramuscular saline was administered to the control group as placebo. Salin intramuscular (IM) injection was performed when cervical dilatation was at or greater than 4 cm and the cardiotocogram uterine contraction recordings of 200 Montevideo units was reached. salon was given following amniotomy.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Active phase of labor with pethidine | The study group that accepted pethidine injection comprised of 132 patients; The active phase duration was evaluated in minutes. | during labor | 
| Labor pain with pethidine | Labor pain VAS scores were determined in both groups just prior to pethidine injection (0.hour), and 1st and 2nd hours after injection. The VAS scale represents pain with a score of 1 to 10. patients scored points on this scale and these scores were recorded. 1 point shows the least pain, 10 points the most-irresistible pain. | during labor | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Analgesia, labor, pethidine, Active Phase