Prevention of Adolescent Major Depression

Study Overview
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Brief Summary
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The main purpose of this study is to assess the effect of a cognitive group intervention on prevention of major depression in 14-15-year-old adolescents. Moreover, the effect on other selected mental health parameters are investigated.

Official Title
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Adolescents Coping With Stress: Prevention of Adolescent Major Depression in School Health Care

Conditions
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Depressive Disorder

Intervention / Treatment
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* Behavioral: the Adolescent Coping with Stress
* Behavioral: Treatment as usual
* Other: usual health education


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: mild to moderate level depressive symptoms (RBDI self-report scale) adequate knowledge of the Finnish language informed consent from the adolescent (all) and his/her parent (under 15 years) healthy controls comprise subjects with no depressive symptoms Exclusion Criteria: ongoing major depression, dysthymia or bipolar disorder ongoing other severe psychiatric illness precluding group participation mental retardation

Ages Eligible for Study
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Minimum Age: 14 Years
Maximum Age: 16 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>Group cognitive intervention (the Adolescent Coping with Stress) | Behavioral: the Adolescent Coping with Stress<br>* A group cognitive intervention, manualized and highly structured. Includes 8 sessions (á 1.5 hours) and a booster session 6 months after termination of the actual intervention. Groups leaders are specifically trained for this course.<br>|
| Active Comparator: 2<br>Treatment as usual | Behavioral: Treatment as usual<br>* The usual treatment received by the adolescent with mild to moderate self-reported depressive symptoms in school health care.<br>|
| Active Comparator: 3<br>Healthy controls, receive usual health education in school health care | Other: usual health education<br>* usual health education given by the school nurses, targeted for healthy controls with no depressive symptoms according to the self-report scale<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Major depression (diagnostic interview) High level of depressive symptoms (self-report scale) |  | 3 months, 6 months, 12months, 24 months, 36 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Suicidality (diagnostic interview, self-report scale) |  | 3 months, 6 months, 12 months, 24 months, 36 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Depressive Disorder, Depressive Disorder, Major, Mental Health, Prevention