Genetic Studies of Early-onset Dementia

Study Overview
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Brief Summary
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The aim of this study is to identify genetic factors that contribute to risk and progression of early-onset dementia (loss of memory function before the age of 70 years) across all ethnic groups, including Alzheimer's Disease, mild cognitive impairment and other dementias.

Detailed Description
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The study population includes individuals affected by Alzheimer's Disease, mild cognitive impairment, other dementias, cognitively healthy individuals without memory problems, or their family members. Ascertainment is across both males and females, and all race and ethnic groups.

Official Title
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Genetic Studies of Early-onset Dementia

Conditions
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Dementia, Early Onset

Intervention / Treatment
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* Genetic: Blood draw
* Other: Neurocognitive testing
* Other: Medical questionnaire


Participation Criteria
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Eligibility Criteria
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Inclusion criteria: 18 years and older Individuals diagnosed with dementia, their family members and unrelated healthy controls without dementia. Exclusion Criteria: -Individuals with competing diagnosis such as Huntington's disease, traumatic brain injury, drug or alcohol abuse, or schizophrenia, etc., unless family members of a dementia affected individual

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Mild Cognitive Impairment<br>Individuals with mild cognitive impairment that began before age 70 | Genetic: Blood draw<br>* Blood draw for identification of genetic variants associated with the development of memory problems<br>Other: Neurocognitive testing<br>* Brief memory test<br>Other: Medical questionnaire<br>* Collection of medical history<br>|
| Dementia/Alzheimer's Disease<br>Individuals with Alzheimer's Disease or other dementia that began before age 70 | Genetic: Blood draw<br>* Blood draw for identification of genetic variants associated with the development of memory problems<br>Other: Neurocognitive testing<br>* Brief memory test<br>Other: Medical questionnaire<br>* Collection of medical history<br>|
| Cognitively Healthy<br>Cognitively healthy individuals over the age of 30 years | Genetic: Blood draw<br>* Blood draw for identification of genetic variants associated with the development of memory problems<br>Other: Neurocognitive testing<br>* Brief memory test<br>Other: Medical questionnaire<br>* Collection of medical history<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Genetic risk variants associated with early-onset dementia | Genetic factors will be measured through genome-wide genotyping arrays and/or whole-genome sequencing, and then correlated with Alzheimer disease and related phenotypes, such as cognitive impairment, functional impairment, and relevant biomarkers. | 2 years | 
| Changes in blood biomarkers in early-onset dementia | Blood biomarkers including plasma amyloid beta and tau protein will be assessed in blood and correlated with onset and progression of memory loss and functional impairment | 2 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Alzheimer's Disease, Memory loss, Early-onset Alzheimer's disease, Mild cognitive impairment, Normal cognition, Dementia, Genetics