Idiopathic Pulmonary Fibrosis Job Exposures Study

Study Overview
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Brief Summary
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A case-control study to investigate whether job exposures are an under-recognized cause of idiopathic pulmonary fibrosis (IPF) using an interview to collect information about previous jobs and a blood test to investigate genetic susceptibility.

Detailed Description
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Idiopathic pulmonary fibrosis (IPF) is a scarring lung disease. It damages the air sacs that allow oxygen to be transferred into the blood and transported to vital organs. These changes make people with IPF cough and feel short of breath. It not known what causes the damage. People who get IPF are usually older than 40; it's a very serious illness that cannot be cured and gets worse over time. Statistics show that IPF is becoming more common in the UK but it's not known why. It can be difficult for doctors to tell if someone has IPF or another disease called asbestosis.

Official Title
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Idiopathic Pulmonary Fibrosis Job Exposures Study

Conditions
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IPF, Idiopathic Pulmonary Fibrosis

Intervention / Treatment
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* Other: Computer-assisted telephone interview
* Genetic: Genetic analysis


Participation Criteria
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Eligibility Criteria
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For cases Inclusion Criteria: New diagnosis of IPF between February 2017 and October 2019 Exclusion Criteria: Unable to give informed consent Ever worked outside of the UK For controls Inclusion Criteria: New outpatient department attendee between February 2017 and October 2019 Exclusion Criteria: Unable to give informed consent Ever worked outside of the UK (does not include work outside the UK by members of the armed forces or merchant navy) Diagnosis of IPF
Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Case<br>Males with an incident diagnosis of IPF made between the 1st of February 2017 and the 5th of October 2019. | Other: Computer-assisted telephone interview<br>* Occupational history<br>Genetic: Genetic analysis<br>* To include analysis of known susceptibility markers<br>|
| Controls<br>Males with an incident hospital outpatient attendance between the 1st of February 2017 and the 5th of October 2019 who do not have a diagnosis of IPF. At each participating centre a control clinic is randomly selected from all control clinics that the research team is able to recruit from; this clinic is the source clinic for controls for the duration of the study. | Other: Computer-assisted telephone interview<br>* Occupational history<br>Genetic: Genetic analysis<br>* To include analysis of known susceptibility markers<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Association between asbestos exposure and IPF | estimated using logistic regression for any vs no asbestos exposure and adjusting for age and smoking status | 2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Dose-response relationship between asbestos exposure and IPF | estimated using logistic regression for categories of cumulative exposure and adjusting for age and smoking status | 2 years | 
| Gene-environment interaction (for MUC5B rs35705950 and asbestos exposure) odds ratio. | MUC5B rs35705950 and asbestos exposure odds ratio. | 2 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Idiopathic Pulmonary Fibrosis