Impact of Adapted Physical Activity on Patient's Recovery Following Allogeneic Stem Cell Transplantation for Hematological Malignancy

Study Overview
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Brief Summary
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It is a study about adaptated physical activity for patients receiving a stem cell transplantation. They will benefit of 6 adaptated individuals lessons at home between 1 month and 3 months after stem cell transplantation. The study's goal is to observe if adaptated activity has an positive impact on weight loss and on life quality.

Official Title
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APALLO : Post Allogeneic Stem Cell Transplantation Adapted Physical Activity for Patient With Hematological Malignancies

Conditions
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Haematological Malignancy

Intervention / Treatment
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* Other: 6 sessions of adapted physical activity after stem cell transplant


Participation Criteria
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Eligibility Criteria
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Inclusion criteria : Patient aged 18 or more Patient with social security Patient who accept the study and sign the consent form Patient programmed for an allogenic stem cell transplantation Non inclusion criteria : Patients with a guardianship Patients with a significant additional physic or mental disease Exclusion criteria Patients who did not receive an allogeniac stem cell transplantation Patients still hospitalized between day 30 and day 100 after stem cell transplantation Patients who finally refuses the study Patients who develop a physical or mental incapacity to practice physical activity

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: adapted physical activity<br>6 sessions of physical activity | Other: 6 sessions of adapted physical activity after stem cell transplant<br>* physical assessement before and after stem cell transplant: weight loss brachial muscle circumference grip strength evaluation short physical battery test psychometric assessment before and after stem cell transplant: quality of life questionary physical activities questionary<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| weight loss | Body weight n in kilograms | before stem cell transplantation, 1 month , 3 months, 1 year after stem cell transplantation | 
| weight loss | Calculation of the percent of body weight loss between the  before stem cell transplantation evaluation  and each evaluation after stem cell transplantation and after adaptated physical activity sessions. | before stem cell transplantation, 1 month , 3 months, 1 year after stem cell transplantation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| patient's ability to attend the classes | number of adaptated physical activity lessons attended by each patient after stem cell transplantation, calculation of feasibility | 3 months after stem cell transplantation | 
| body mass index | Measure of weight and height to evaluate the nutriotional status of a patient | before stem cell transplantation, 1 month , 3 months, 1 year after stem cell transplantation | 
| brachial muscle circumference | evaluation in centimeters of the brachial circumference to evaluate the evolution of the muscle circumference after stem cell transplantation and adaptated physical activity compared to the evaluation before stem cell transplantation. Using a measuring tape | before stem cell transplantation , 1 month , 3 months, 1 year after stem cell transplantation | 
| grip strength evaluation | it is a measure of muscular strength | before stem cell transplantation , 1 month , 3 months, 1 year after stem cell transplantation | 
| short physical battery test | it is a series of 3 physical tests to evaluate mobility the first test is a balance test (4 points), the second test is an evaluation of a walking speed (4 points) and the third test is a Chair rise test (4 points) The global test is on 12 points (12 is the better score) | before stem cell transplantation , 1 month , 3 months, 1 year after stem cell transplantation | 
| Quality of Life Questionary C30 (QLQ-C30) | it is a score to evaluate the quality of life of patients facing illness The subscales scores are transformed to a 0 to 100 scale, with higher score on functionnal scales indicating better function and higher scores on sumptom scales indicating worse symptoms | before stem cell transplantation , 1 month , 3 months, 1 year after stem cell transplantation | 
| in house developped physical activities questionary | it is a questionnary created especially for this study to evaluate on each step the capacity of each patient to maintain physical activities (social activities, autonomy at home for cooking and hygiene care, autonomy for transport to go to hospital appointments) | before stem cell transplantation , 1 month , 3 months, 1 year after stem cell transplantation |