Sleep Disturbances and Chronic Widespread Pain

Study Overview
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Brief Summary
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Chronic widespread pain (CWP), defined as long-lasting pain in multiple body regions, has a prevalence of 10-14% in Europe and is associated with other physical symptoms such as fatigue and cognitive problems. Individuals with longstanding pain also have a high prevalence of sleep disturbances, and sleep problems can in itself lead to tiredness, lower neurocognitive function and higher pain ratings. However, studies of comorbid sleep problems for individuals with CWP are a lacking, and the primary aim for the present study is to assess the prevalence of sleep disturbances in individuals with CWP, and to see how this covariates with pain, fatigue, activity level, neurocognitive functioning, and biomarkers. As a secondary aim the study will assess a subgroup of the individuals, that has received multimodal pain management treatment, a second time after 6 months to analyze how the prevalence of sleep disturbances and other associated problems covaries over time.

Official Title
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Prevalence of Sleep Disturbances in Individuals With Chronic Widespread Pain

Conditions
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Chronic Widespread Pain, Sleep Disturbance

Intervention / Treatment
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* Diagnostic Test: Polysomnography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Chronic Widespread Pain Exclusion Criteria: Other untreated and or serious psychiatric or somatic conditions

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Intervention<br> | Diagnostic Test: Polysomnography<br>* Sleep screening, neurocognitive assessment, activity monitoring questionnaires, blood sample<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Polysomnography | Assessment of objective sleep problems | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| CANTAB | Neurocognitive screening | 6 months | 
| Actigraph | Activity level | 6 months | 
| Biomarkers | 92-plex inflammatory panel | 6 months | 
| Pain level | The Brief Pain Inventory - Short Form, BPI, a 9 item (0-10) self-administered questionnaire, assessing the severity of a patient's pain and the impact of this pain on the patient's daily functioning. Maximum total score possible is 90. Higher the score, greater the degree of disability. | 6 months | 
| Fatigue | Fatigue severity scale, FSS, a 9 item self-administered questionnaire assessing severity of fatigue and how fatigue interferes with activity. Items are scored on a 7 point scale, minimum total score possible is 9 and maximum 63. Higher the score, greater the severity. | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Pain, Sleep, Neuropsychology, Fatigue, Activity level, Attention, Executive function, Memory