Prognostic Value of Proadrenomedullin in Intra-abdominal Sepsis

Study Overview
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Brief Summary
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An observational, prospective study whose main objective is to measure the value of Pro-adrenomedullin as a prognostic marker and predictor of mortality in patients with intra-abdominal sepsis after damage control surgery.

Detailed Description
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Proadrenomedullin as a Severity Score and Prognostic Marker in Intra-abdominal Sepsis Research Type: Prospective, observational study. Duration: October 2016 - October 2017 Associated Medical Centers: La Paz University Hospital (Madrid), La Princesa Hospital (Madrid), Hospital del Mar (Barcelona), Hospital Clínico de Valladolid and Hospital Clínico de Valencia. Main Goal: To measure the value of Pro-adrenomedullin as a prognostic marker and predictor of mortality in patients with intra-abdominal sepsis after damage control surgery. Secondary Goals: Make a comparison with other biomarkers (procalcitonin, lactic acid, CRP) and clinical severity scales used in standard critical practice (SAPSII, SOFA). To establish a correlation between the levels of Pro-Adrenomedullin, the time of stay in critical care units, days of mechanical ventilation and mortality. Variables: A. Demographics B. Date of admission to hospital and date of admission to critical care unit unit C. Clinical data: Associated diseases SAPS II SOFA D. Intra-abdominal infection episode data Systemic response: sepsis / septic shock Isolated microorganisms in blood cultures and intra-abdominal fluid Complications related to the infectious process (ARDS, need for mechanical ventilation, vasopressors, disseminated intravascular coagulation, acute renal failure, renal replacement techniques) E. Follow-up Critical unit registration date Date of discharge from hospital Critical unit mortality, in-hospital mortality and 30 days mortality (assessed by telephone contact if the patient had been discharged). F. Pro-adrenomedullin levels at admission, 24 and 72 hours. As well as procalcitonin (PCT), lactic acid and polymerase Chain Reaction (PCR) levels.

Official Title
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Proadrenomedullin as a Severity Score and Prognostic Marker in Intra-abdominal Sepsis

Conditions
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Intraabdominal Infections

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All patients consecutively collected, adults over 18, who are admitted to critical care unit with the diagnosis of localized or generalized intraabdominal infection after damage control surgery. Exclusion Criteria: Pregnant or lactating women. Patients with neutropenia induced by bone marrow transplant or by chemotherapy (<500 neutrophils / ml).

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| mortality |  | 30 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| days of stay in critical units |  | 30 days | 
| days of mechanical ventilation |  | 30 days | 
| days of need vasopressors |  | 30 days | 
| days of need for renal replacement techniques |  | 30 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Proadrenomedullin, Sepsis, Intraabdominal Infections, prognosis