Diffusion Weighted Magnetic Resonance Imaging for Preoperative Staging in Gastric Adenocarcinoma Patients

Study Overview
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Brief Summary
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Preoperative staging for gastric adenocarcinoma is an important procedure to detect advanced disease stateS for the patients in which the surgery may be unnecessary to perform. Although there are many imaging techniques for this purpose, sensitivity and specificity of these techniques still remains to be low.Preoperative detection of peritoneal carcinomatosis and involvement of lymph nodes beyond D2 may prevent surgical procedures. Removal of the determined lymph nodes according to the type of the surgery is the accepted surgical method. However, accurate determination of malignant lymph nodes may prevent dissection of some groups of the lymph nodes. These findings may cause a new definition of gastric lymph node dissection.

Detailed Description
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proven endoscopic diagnosis of gastric adenocarcinoma for staging purposes, computed tomography for all patients evaluation of benign and malignant lymph nodes according to computed tomography findings and mapping of the lymph nodes to state precisely resectable patients according to computed tomography and anesthetic evaluation evaluation of benign and malignant lymph nodes according to diffusion weighted magnetic resonance imaging findings and mapping of the lymph nodes standard gastrectomy and D2 lymph node dissection mapping of the lymph nodes after taking the specimen out histopathological diagnosis of the lymph nodes and mapping comparison of the results taken from computed tomography, diffusion weighted magnetic resonance imaging and histopathological analysis

Official Title
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Use of Diffusion Weighted Magnetic Resonance Imaging to Stage Gastric Adenocarcinoma Patients Preoperatively

Conditions
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Gastric Adenocarcinoma

Intervention / Treatment
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* Procedure: diffusion weighted magnetic resonance imaging


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: gastric adenocarcinoma proven by endoscopic biopsy; application of both computed tomography and diffusion weighted magnetic resonance imaging; standard gastrectomy and a D2 lymph node dissection; desire to attend the study protocol Exclusion Criteria: preoperative neoadjuvant therapy; metastatic disease; undesired reaction to attend the study protocol

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: diffusion MRI<br>histopathology of lymph nodes diagnosed by diffusion weighted magnetic resonance imaging | Procedure: diffusion weighted magnetic resonance imaging<br>* for diagnostic purposes, diffusion weighted magnetic resonance imaging in all patients<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| efficacy of diffusion weighted magnetic resonance imaging to detect benign and malignant lymph nodes | to compare the radiologic diagnosis of benign and malignant lymph nodes with histopathological diagnosis | one year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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diffusion weighted, magnetic resonance imaging, surgery, histopathology