Effect of Aqueous Extract of Garlic and Nystatin Mouthwash in Denture Stomatitis

Study Overview
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Brief Summary
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The aim of the present study was to compare the effect of aqueous extract of garlic with nystatin mouthwash in denture stomatitis.

Detailed Description
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Denture stomatitis is the most common form of chronic oral candidiasis manifested as chronic inflammation of the mucous membrane t supporting the movable prosthesis that may have a local or systemic nature. This inflammation is presented as mucous erythema and occasionally with pain and burning. The standard treatment for denture stomatitis is administration of nystatin which is accompanied with complications such as bitter taste as well as the high number of drug application that result in reduced tendency of patients in using this medication hence, efforts are continuously being made to substitute other types of therapies for this condition.

Official Title
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Comparison of Therapeutic Effect of Aqueous Extract of Garlic and Nystatin Mouthwash in Denture Stomatitis

Conditions
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Denture Stomatitis

Intervention / Treatment
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* Drug: garlic , nystatin


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 40 years of age and older confirm of denture stomatitis by the oral medicine specialists Exclusion Criteria: Patients with a history of using anti-fungal drugs, antibiotics, and corticosteroid within the previous month allergy to garlic and nystatin mouthwash immunodeficiency uncontrolled diabetes those with garlic rich diet inability in using mouthwash loose and discolored dentures psychologic disorder and alzheimer

Ages Eligible for Study
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Minimum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: drug: garlic extract, nystatin<br>Drug: garlic extract 40mg/dl or nystatin suspension 100000 iu/ml tid for one month Patients had been clinically with denture stomatitis and confirmed by oral medicine specialist were selected for the study. Gender, age, medical history, erythema types, size, and other treatment used for this disease were recorded. Local ethical committee approval was obtained before the trial started and all patients gave written informed consent. Patients were randomly divided into two groups .First group received garlic extract and second group used nystatin suspension for 1 month. Each patients was examined at the beginning of the therapy ,and then every 1 weeks up to 1 months . | Drug: garlic , nystatin<br>* mouthwash<br>* Other names: aquous garlic;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| reduction of diameter of erythematous lesion under denture | measuring erythematous lesion by visual and then photography and a colis | first week | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| complete relief of erythematous lesions |  | fourth week | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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denture stomatitis, nystatin, garlic