Identification of Risk Factors for Alteration of the Cellular-arterial Gradient of CO2

Study Overview
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Brief Summary
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Monocentric, prospective, observational and descriptive study on the evaluation of risk factors for alteration of the alveoarterial gradient of CO2 in pre-hospital patients, intubated and then ventilated in an invasive manner; and their impact on intra-arterial fatehospital.

Official Title
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DELTA-CAPNO: Identification of Risk Factors for Alteration of the Cellular-arterial Gradient of CO2 in Pre-hospital Patients

Conditions
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Mechanical Ventilation, Prehospital Capnography Monitoring

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 18 years of age, Endotracheal intubation in pre-hospital and mechanical ventilation, Monitoring of Etco2 in pre-hospital settings Exclusion Criteria: Identification of a chest wound blowing during pre-hospital care, No technical possibility for performing or analysing arterial sampling, Death during pre-hospital care, A person who has objected to the processing of his data for research at minimal risk and constraints (category 2) or for research on data, as well as persons subject to legal protection measures.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 100 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| identification of risks factors for alteration of the cellular arterial gradient of CO2 in Pre hospital patients | The main objective is therefore to determine the main risk factors to observe an alteration of the alveoarterial gradient in CO2, at the hospital care (fixed at 10 mmHg). | from january 2020 to april 2021 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Intrahospital mortality | prognostic evidence of altered alveocapillary gradient on intrahospital mortality | from january 2020 to april 2021 | 
| Time of hospital admission | the prognosis of the finding of an altered alveocapillary gradient on the time of hospital admission | from january 2020 to april 2021 | 
| length of mecanical ventilation | the prognosis of the finding of an altered alveocapillary gradient on the duration of ventilation | from january 2020 to april 2021 | 
| Occurence of pneumonia | the prognosis of the finding of an altered alveocapillary gradient on the occurrence of pneumonia | from january 2020 to april 2021 | 
| Acute respiratory distress syndrom (ARDS) | the prognosis of the finding of an altered alveocapillary gradient on the occurrence of ARDS | from january 2020 to april 2021 | 
| Length of stay | the prognosis of the finding of an altered alveocapillary gradient on the length of stay | from january 2020 to april 2021 | 
| Intrahospital mortality (subpopulation of traumatized patients which had suffered from intracranial hypertension | prognostic evidence of altered alveocapillary gradient, onset of an episode of intracranial hypertension, and intrahospital survival of severely traumatized patients (GCS < 9). | from january 2020 to april 2021 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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capnography prehospital