Curcumin Paste as an Adjunctive Therapy in Periodontitis

Study Overview
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Brief Summary
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The turmeric (Curcuma longa) plant, a herb belonging to the ginger family. The most active component of turmeric is curcumin, which makes up 2 to 5% of the spice. Curcumin showed has antibacterial effect against periodontal pathogen and positive result regarding conventional treatment of periodontal disease due to its anti-inflammatory, anti-oxidant and wound healing properties. This study will be carried out to examine the effect of curcumin when used in conjunction with open flap debridement treating deep periodontal pockets. (suggesting that it may have positive effect)

Detailed Description
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The present study entailed twenty four patients having stage II or stage III, Grade A periodontitis with 24 intrabony defects. Patients were divided into two groups; group I was subjected to open flap debridement only. Group II was subjected to curcumin paste (2%curcumin)in conjunction with open flap debridement Clinical parameters including plaque index, sulcus bleeding index, probing depth and clinical attachment level were recorded pre-surgical. Moreover, radiographic examination was performed by cone beam computed tomography (CBCT) just before the surgery . Vertical bone defects were exposed by full thickness mucoperiosteal flap following intrasulcular incision and thorough debridement was performed. Group II received local application of curcumin paste.The same initial clinical parameters were recorded three and six months postoperatively. Radiographic measurements were recorded six months post surgically.

Official Title
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The Local Application of Curcumin in Conjunction With the Surgical Treatment of Intrabony Periodontal Defects Controlled Clinical Study With Evaluation of Curcumin Release Profile

Conditions
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Periodontitis

Intervention / Treatment
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* Drug: curcumin paste
* Procedure: curettage


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Male or female with age range 25-45 years. At least a single posterior 2-3 wall periodontal defect of pocket depth ≥ 5mm; clinical attachment level ≥ 3 mm, Intrabony component ≥ 3 mm and with plaque index ≤1 (Löe 1967) and bleeding index ≤1 (Mühlemann & Son 1971). All the previous criteria were determined 2 weeks after phase I conventional periodontal therapy. Systemically Healthy as evidenced by Burket's oral medicine health history questionnaire (Glick et al., 2008). Exclusion Criteria: 1- Smokers. 2- Pregnant. 3- Patient unwilling to comply to periodontaloral hygienic instructions. 4- Vulnerable groups. (e.g: Decisionally impaired individual)

Ages Eligible for Study
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Minimum Age: 25 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: curcumin paste in conjunction with open flap debridement surge<br>curcumin paste (2% circumin) in conjunction with open flap debridement surgery | Drug: curcumin paste<br>* curcumin is a herb used for medical purpose<br>Procedure: curettage<br>* open flab debridement surgery<br>|
| Placebo Comparator: open flap debridement surgery only<br>surgical treatment for periodontal pocket | Procedure: curettage<br>* open flab debridement surgery<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| clinical score | Evaluate the influence of curcumin paste on the clinical outcomes of the surgical treatment.to see if curcumin has a positive effect in reduction oh deep periodontal pockets and leads to greater bone gain | change from base line at 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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curcumin, CBCT, HPLC, periodontitis