Role of Dietary Habits in Efficacy of Bariatric Surgery - Study B

Study Overview
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Brief Summary
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The purpose of the study is to compare dietary habits after bariatric surgery in patients with poor weight loss versus good weight loss outcomes.

Detailed Description
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The obesity epidemic is a major public health concern with a significant economic burden in the USA. Bariatric surgery is the most effective and durable weight loss treatment, with long-term cardiometabolic health benefits. Among different types of bariatric procedures, sleeve gastrectomy (SG) has become the most commonly performed in USA. While SG is expected to result in a 50-60% excess weight loss, inter-individual differences in weight loss are large and approximately 25% of patients can be considered poor weight-loss responders who either do not lose a substantial amount of weight or regain the lost weight afterwards. The mechanisms underlying this clinical variation remain unknown and interventions to improve on these outcomes critically lacking. Of interest, altered daily dietary habits are experienced by a substantial proportion of bariatric surgery candidates, raising the question whether such alterations may contribute to inter-individual differences in weight loss success. Therefore, the purpose of the study is to compare dietary habits after bariatric surgery in patients with different weight loss outcomes.

Official Title
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Role of Dietary Habits in Efficacy of Bariatric Surgery - Study B

Conditions
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Obesity, Bariatric Surgery, Sleeve Gastrectomy

Intervention / Treatment
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* Other: In-laboratory assessment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Bariatric surgery (sleeve gastrectomy) patients Exclusion Criteria: Insulin-dependent diabetes Anemia Smoking Shift work within the past 1 year Drug or alcohol dependency Bipolar disorder Post traumatic stress disorder (PTSD)

Ages Eligible for Study
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Minimum Age: 22 Years
Maximum Age: 62 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Weight loss < median of group<br>Sleeve gastrectomy surgery patients will take part in in-laboratory assessment. Based on 1-year post-surgical weight loss, a median split will be done to allocate subjects to one of two groups. | Other: In-laboratory assessment<br>* Participants will stay in the laboratory for two days and one night during which they will complete questionnaires, have blood drawn, and have other measurements taken.<br>|
| Weight loss > median of group<br>Sleeve gastrectomy surgery patients will take part in in-laboratory assessment. Based on 1-year post-surgical weight loss, a median split will be done to allocate subjects to one of two groups. | Other: In-laboratory assessment<br>* Participants will stay in the laboratory for two days and one night during which they will complete questionnaires, have blood drawn, and have other measurements taken.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Self-rated hunger | Hunger measured from the visual analogue scale (VAS) questionnaire | One day of laboratory protocol | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Self-rated appetite | Appetite measured from the visual analogue scale (VAS) questionnaire | One day of laboratory protocol | 
| Appetite-regulating hormones | Appetite-regulating hormones from blood samples | One day of laboratory protocol | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Weight changes, Diet, Dietary Habits