The Effects of Ultrasound-guided Serratus Plane Block During Video-assisted Thoracoscopic Lobectomy

Study Overview
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Brief Summary
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This study evaluates the effects of serratus plane block on intraoperative opioid consumption, emergence time and hemodynamic stability in patients undergoing video-assisted thoracic surgery.

Detailed Description
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Thoracotomy is known as one of the most painful surgery. Thus, there is a development to reduce surgical stress in terms of operation technique, which is video-assisted thoracoscopic surgery. Although it has reduced postoperative pain and complications compared with thoracotomy, VATS is still quite painful operation. Serratus plane block is a novel technique which provide analgesic effect for lateral chest wall by blocking lateral branch of intercostal nerve. It has been reported to be used for pain management including rib fracture, herpes zoster, and postoperative pain. It has become a popular analgesic modality because it is easy to perform and relatively safe. However, the effect of serratus plane block during intraoperative period has not yet been studied. In this study, therefore, the investigators decided to assess the effect of serratus plane block on intraoperative opioid consumption, emergence time and hemodynamic stability in patients undergoing video-assisted thoracic surgery.

Official Title
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The Effects of Ultrasound-guided Serratus Plane Block in Combination With General Anesthesia on Intraoperative Opioid Consumption, Emergence Time and Hemodynamic Stability During Video-assisted Thoracoscopic Lobectomy

Conditions
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Anesthesia, Conduction, Pain Management

Intervention / Treatment
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* Procedure: Serratus plane block
* Procedure: General anesthesia only


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: American Society of Anesthesiologists physical status classification I-III for three port video-assisted thoracic surgery lobectomy under general anesthesia Exclusion Criteria: History of allergic reaction to local anesthetics, coagulopathy, local infection at the injection site, and systemic infection.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Serratus plane block<br>The subjects were received serratus plane block in the regional-anesthesia unit out of operation room before induction of general anesthesia. And, video-assisted thoracic surgery was performed under balanced general anesthesia. | Procedure: Serratus plane block<br>* The subjects were received serratus plane block in the regional-anesthesia unit out of operation room before induction of general anesthesia. And, video-assisted thoracic surgery was performed under balanced general anesthesia.<br>|
| Active Comparator: General anesthesia only<br>Video-assisted thoracic surgery was performed under balanced general anesthesia without serratus plane block | Procedure: General anesthesia only<br>* Video-assisted thoracic surgery was performed under balanced general anesthesia without serratus plane block<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Intraoperative remifentanil consumption | Intraoperative remifentanil consumption will be checked. | through study completion, an average of 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Emergence time | Emergence time is duration between the end of surgery and extubation. Emergence time will be checked. | through study completion, an average of 1 year | 
| Systolic blood pressure | Systolic blood pressure (mmHg) will be checked | through study completion, an average of 1 year | 
| Heart rate | Heart rate (beats per minute) will be checked | through study completion, an average of 1 year | 
| Dose of rescue drugs used to control blood pressure and HR | Dose of rescue drugs used to control blood pressure and HR will be checked | through study completion, an average of 1 year |