Risk Prediction of Bleeding in Liver Cirrhosis by Combi-elastography

Study Overview
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Brief Summary
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Through the parameters of liver stiffness and spleen stiffness obtained by combi-elastography technique, summarize and analyze the warning index of esophagogastric variceal bleeding in patients with cirrhosis, so as to provide a new and valuable technique for clinical diagnosis.

Detailed Description
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Firstly,the combi-elastography technique developed by HITACHI uses the method of multi-index and multi-parameter to evaluate the liver stiffness and spleen stiffness comprehensively. And then,this prospective study is designed to follow up patients with cirrhosis for a period of 12 months, summarize and analyze the warning index of bleeding in patients with cirrhosis,so as to provide a new and valuable technique for clinical diagnosis.

Official Title
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Risk Prediction of Bleeding in Liver Cirrhosis by Combi-elastography

Conditions
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Liver Cirrhosis, Gastroesophageal Varices, Variceal Hemorrhage

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 18-80 years old, no gender limit; The clinical diagnosis is in line with patients with liver cirrhosis caused by chronic hepatitis B, and the gastroscopy is in line with the indications of portal hypertension; Gastroscopy needs to provide the degree of gastroesophageal varices; Sign the informed consent form. Exclusion Criteria: Patients with cirrhosis and portal hypertension because of other causes or combined with other causes(such as viral hepatitis other than hepatitis B,Autoimmune liver disease, alcoholic liver disease, metabolism-related fatty liver disease, etc.) Patients with a history of spleen-related operations, such as splenectomy, splenic embolism; Patients undergoing portosystemic shunt or TIPS; Isolated esophageal venous tumor and its bleeding patients; History of upper gastrointestinal tumor or bleeding from gastric ulcer , etc; Those with serious diseases of other systems that cannot cooperate with elastography examination, such as heart failure, renal failure, mental illness, etc; Ascites before liver and spleen result unable to complete elasticity examination; Pregnant patients.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| F index | F index is linked to the degree of liver fibrosis,and it can be available by ultrasound elastography checking. | baseline | 
| A index | A index is linked to the degree of hepatitis ,and it can be available by ultrasound elastography checking. | baseline | 
| Spleen stiffness | Spleen stiffness can be available by ultrasound elastography checking. | baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Elasticity Imaging Techniques, Ultrasound