Prognostic Factors for Descending Necrotizing Mediastinitis Development in Deep Space Neck Infections

Study Overview
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Brief Summary
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Descending necrotizing mediastinitis (DNM) is the most serious complication of deep neck infections (DNI) with high mortality. The objective of this retrospective study was to evaluate possible prognostic factors for DNM development in deep space neck infections.

Detailed Description
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Descending necrotizing mediastinitis (DNM) is the most serious complication of deep neck infections (DNI) with high mortality. The objective of this retrospective study was to evaluate possible prognostic factors for DNM development in deep space neck infections. The study enrolled patients admitted to the Emergency Center of Vojvodina with the diagnosis of multispace DNI with or without DNM either as the primary diagnosis or with discharged diagnosis after surgical treatment during 7-years period. The data were obtained from patient medical records.

Official Title
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Prognostic Factors for Descending Necrotizing Mediastinitis Development in Deep Space Neck Infections - A Retrospective Study

Conditions
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Infection, Mediastinitis, Neck Abscess, Inflammation

Intervention / Treatment
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* Other: treatment of infection


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients admitted to the hospital due to deep neck infection affecting two or more spaces with or without descending necrotizing medioastinitis complete diagnosis and treatment data available from medical charts Exclusion Criteria: incomplete medical data infection confined to one deep neck space patients treated under local anesthesia patients with superficial skin infections iatrogenic infections infected tumors
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| DNI group<br>patients with infection of two or more deep neck spaces (DNI group) | Other: treatment of infection<br> <br> |
| DNI + DNM group<br>patients with infection of two or more deep neck spaces with secondary descending necrotizing mediastinitis (DNI + DNM group) | Other: treatment of infection<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of mediastinitis | Neck and chest computed tomography (CT) | Within 6 hours of admission | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Microbiological findings in DNI and DNM | Prevalence of microorganisms in mediastinitis | Within 1 week of admission | 
| Average number of hospital days | Comparison of average number of hospital days in DNI and DNM | Through study completion, an average of one month | 
| Incidence of complications | Complications among DNI and DNI+DNM groups | Within 30 days from admission | 
| Number of infected deep neck spaces | Neck and chest computed tomography (CT) | Within 6 hours of admission |