Dietary Antioxidants and Chronic Diseases-The Swedish National March Cohort

Study Overview
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Brief Summary
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Dietary antioxidants might protect from the development of chronic diseases by reducing levels of oxidative stress. The investigators therefore investigated the effect of dietary Non Enzymatic Antioxidant Capacity, which measures interactions between antioxidants in the whole diet, on the risk of 1) myocardial infarction and 2) osteoarthritis.

Detailed Description
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Aim: Among an initial sample of 43,880 men and women who participated in the Swedish National March Cohort in 1997 the investigators aimed to investigate the effect of dietary Non Enzymatic Antioxidant Capacity (NEAC), assessed by a validated food frequency questionnaire at baseline, on the risk of 1) myocardial infarction and 2) osteoarthritis. Identification of cases: Incident cases of myocardial infarction (ICD-10 code I21) and osteoarthritis (ICD-10 M15-19) were identified through exact linkages to the Swedish registries of population, migration, death, cancer, and inpatient care, using the national registration numbers as identifiers. Main methods: The investigators fitted Cox proportional hazards regression models with age as underlying time scale to estimate hazard ratios (HR) with 95% confidence intervals (95% CI) for each outcome of interest at different levels of dietary NEAC. The investigators fitted multiple imputation models based on chained equations to address missingness of confounder variables.

Official Title
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Study 1: Dietary Non Enzymatic Antioxidant Capacity and the Risk of Myocardial Infarction - The Swedish National March Cohort; Study 2: Dietary Total Antioxidant Capacity and Risk of Osteoarthritis in the Swedish National March Cohort

Conditions
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Myocardial Infarction, Diet, Osteoarthritis

Intervention / Treatment
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* Other: Total dietary NEAC assessed at baseline


Participation Criteria
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Eligibility Criteria
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Exclusion Criteria Study 1: Incorrect national registration number Subjects who were <18 years Emigration before beginning of follow-up Death before beginning of follow-up Cancer diagnosis Any cardiovascular disease Extreme energy intake Exclusion Criteria Study 2: Incorrect national registration number Subjects who were <40 years Emigration before beginning of follow-up Death before beginning of follow-up Osteoarthritis diagnosis Bone cancer- or metastases Joint injury or any arthropathy disease other than osteoarthritis Extreme energy intake

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Total dietary NEAC assessed at baseline|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Myocardial Infarction | Based on ICD-10 I21 | October 1, 1997-December 31, 2010 | 
| Osteoarthritis | Based on ICD-10 M15-19 | October 1, 1997-December 31, 2010 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Antioxidants, Oxidative Stress, Atherosclerosis, Epidemiology