Gait, cOgnitiOn & Decline (GOOD)

Study Overview
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Brief Summary
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The main objective of the GOOD initiative was to determine which spatio-temporal gait parameters and/or combination(s) of spatio-temporal gait parameters best differentiate between cognitively healthy individuals (CHI), patients with mild cognitive impairment (MCI) and those with mild and moderate dementia.

Detailed Description
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Gait disorders are frequent in individuals with cognitive disorders. However, the profile of spatio-temporal gait parameters in the different cognitive status in aging (from normal cognition to dementia) has been poorly studied. Determining this profile associated with the severity of cognitive disorders may be helpful to understand the complex interplay between gait and cognitive disorders and, thus, may have important implication for the diagnosis process of patients with and without dementia. For instance, defining a motor phenotype of the severity of cognitive disorders by using quantitative gait measurements could be used to improve the prediction and the diagnosis of dementia. The investigators hypothesized that, compared to CHI, people with MCI and mild dementia could be characterized by specific phenotypes of spatio-temporal gait parameters measured with the GAITRite® system, and that these profiles could be explained by declines in domain-specific cognitive performance.

Official Title
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Gait, cOgnitiOn & Decline (GOOD)

Conditions
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Mild Cognitive Impairment, Mild Dementia, Moderate Dementia, Healthy

Intervention / Treatment
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* Other: gait and cognitive testing


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Being 60 years old and older Ability to answer questions Exclusion Criteria: Opposition to the use of information collected for research purposes

Ages Eligible for Study
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Minimum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| cognitively healthy individuals (CHI)<br>CHI were participants without objective cognitive impairment | Other: gait and cognitive testing<br> <br> |
| mild cognitive impairment (MCI)<br>MCI was diagnosed if participants met the following criteria: presence of spontaneous cognitive complaints and objective cognitive impairment | Other: gait and cognitive testing<br> <br> |
| mild and moderate dementia<br>Diagnoses of dementia were assigned according to the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV TR, 2000; Association, 2000; 22) at consensus diagnostic case conferences | Other: gait and cognitive testing<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Spatio-temporal gait parameters | Spatio-temporal gait parameters were measured at steady state walking using GAITRite®-system. | This outcome is assessed at inclusion | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical assessment | This outcome was assessed by a questionnaire. | This outcome is assessed at inclusion | 
| Cognitive status | Cognitive status was assessed by cognitive testing. | This outcome is assessed at inclusion | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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cognitively healthy individuals