Carotid Artery Stent Implantation in the Treatment of Vulnerable Plaque

Study Overview
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Brief Summary
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To investigate the efficacy and safety of carotid stenting for vulnerable carotid plaques. All patients with carotid artery stenosis underwent carotid arterial contrast-enhanced ultrasonography before operation. According to the examination results, they were divided into two groups: vulnerable plaque group and stable plaque group. The incidence of perioperative stroke events in the two groups was compared. The incidence of stroke events in the two groups within 1 year was compared.

Detailed Description
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To enroll 100 cases of patients suffering from carotid artery stenosis。the investigators perform contrast enhanced ultrasound on patients for identifying the vulnerable plagues The investigators divide patients into the stable group and the vulnerable group based on the results of CEUS inspection. All patients undergo carotid stent. To analysis the incidence of postoperative complications such as stroke and mortality within 30 days and to compare the differences between the two groups.

Official Title
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A Controlled Clinical Study of Carotid Artery Stent Implantation in the Treatment of Vulnerable Plaque

Conditions
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Carotid Artery Plaque, Carotid Stenosis, Stent Embolisation

Intervention / Treatment
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* Procedure: carotid artery stenting


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: The patients with ischemic symptom whose carotid stenosis were more than 50% The patients without ischemic symptom whose carotid stenosis were more than 70% Exclusion Criteria: • Confirmed with severe intracranial vascular lesions Suffering from the large area cerebral infarction or critical stroke sequela Restenosis after CEA or CAS Suffering from severe coronary heart disease, respiratory failure,the hypertension difficult to controled Patients with malignant tumor or expected life < 2 years

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Vulnerable plaque group<br>Patients with preoperative contrast-enhanced intra-plaque contrast agent were classified as vulnerable plaque group | Procedure: carotid artery stenting<br>* Implantation of stents at the site of carotid artery stenosis for the treatment of carotid plaque with severe stenosis<br>|
| Stable plaque group<br>The patients with no contrast agent enhancement in the plaque showed preoperative contrast-enhanced ultrasound were classified as stable plaque group | Procedure: carotid artery stenting<br>* Implantation of stents at the site of carotid artery stenosis for the treatment of carotid plaque with severe stenosis<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Perioperative 30-day stroke rate | To determine whether there is a new cerebral infarction by postoperative re-examination of brain MRI and preoperative brain MRI | 30 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 1-year stroke rate after surgery | Stroke rate in ipsilateral carotid artery blood supply area within 1 year after operation | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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vulnerable plague, carotid artery stenosis, carotid stenting