The Effect of Intravenous Lidocaine on Allodynia

Study Overview
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Brief Summary
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The purpose of this study is to study if lidocaine, given intravenously, reduces pain.

Detailed Description
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Clinicians use lidocaine intravenously in a fashion that suggests that it might have analgesic effects. Therefore, we test the hypothesis that lidocaine reduces pain intensity in response to experimental pain.

Official Title
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The Effect of Intravenous Lidocaine on Allodynia (Carl Koller Grant)

Conditions
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Pain

Intervention / Treatment
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* Drug: lidocaine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Chronic Regional Pain Syndrome diagnostic criteria by the Work Safe BC. vi Exclusion Criteria: History of Substance abuse Other Medications: CRPS patients are expected to be treated for chronic pain, whether the current treatment regimen interferes with sensory motor testing will be determined on a case by case basis. Coronary Artery Disease (CAD): unstable Congestive Heart Failure (CHF): unstable Heart Arrhythmia: symptomatic Chronic Obstructive Pulmonary Disease (COPD) Lidocaine Allergy Diagnostic and Statistical Manual of Mental Disorders (Rev IV): Axis I: Common Axis I disorders include depression, anxiety disorders, bipolar disorder, ADHD, and schizophrenia. Axis II: borderline personality disorder, schizotypal personality disorder, antisocial personality disorder, and mild mental retardation. Presence of Contraindications for MRI Presence of electronically, magnetically, and mechanically activated implants Electronically, magnetically, and mechanically activated implants Ferromagnetic or electronically operated active devices like automatic cardioverter defibrillators Cardiac pacemakers Metallic splinters in the eye Ferromagnetic haemostatic clips in the central nervous system (CNS) Claustrophobia Pregnancy

Ages Eligible for Study
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Minimum Age: 19 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Lidocaine<br>Intravenous lidocaine for neuropathic pain | Drug: lidocaine<br>* intravenous, effect site concentration: 2mcg/ml, 15-20 min infusion, once<br>* Other names: Xylocaine;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain Perception | Assessing heat pain perception (pain intensity) before, during, and after lidocaine infusion by means of patient self-report using a mechanical slide algometer. The mechanical slide algometer [Price et al. (1994)] looks like a ruler that exposes a red bar with the end-points: no pain (left) and most pain imaginable (right). The use the slider to express their perceived pain. On the back of the ruler a numerical scale ranging from 0 (no pain) to 10 (worst imaginable pain) translates the patient's rating into a numeric scale. | Participants will be followed from baseline through 128 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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lidocaine, allodynia, chronic regional pain syndrome, pain