Indoor Air Quality and Respiratory Morbidity in School-Aged Children With BPD

Study Overview
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Brief Summary
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Investigators want to learn the role of indoor environmental exposures on respiratory symptoms, and, separately, on lung function deficits in school-aged children with bronchopulmonary dysplasia (BPD).

Detailed Description
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Bronchopulmonary dysplasia (BPD) is the most common respiratory disease affecting children born prematurely and leads to long-term respiratory symptoms and lung function impairment throughout childhood. This study will, evaluate the contribution of indoor sources of respiratory irritants to respiratory health impairment in school-aged children with BPD. State-of-the-art measures of indoor air quality constituents will assess the relationship of nitrogen dioxide (NO2), particulate matter (PM2.5), as well as, concentrations of allergens (mold, mouse, cockroach, pet), endotoxin, air temperature and humidity with concurrently measured respiratory symptoms and lung function in a well-characterized cohort of children with BPD. This research will identify specific harmful components of the indoor environment associated with respiratory morbidity and poor lung function in children with BPD. Investigators will ask the participants to come in for a one time clinic visit for undergoing procedures as well as answering questions regarding health and home environment. During the 1 year of participation there will also be 2 home assessment visits where investigators will take a sample of the home environment as well record home characteristics.

Official Title
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Indoor Air Quality and Respiratory Morbidity in School-Aged Children With BPD

Conditions
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Bronchopulmonary Dysplasia, Chronic Lung Disease of Newborn, Environmental Exposure

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: children 6-12 yrs old born <32 wks gestational age diagnosis of BPD or > 28 days of oxygen or respiratory support Exclusion Criteria: major airway or chest surgery physical or mental impairment that will prevent from doing spirometry plans to move out of state within the next 9 months

Ages Eligible for Study
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Minimum Age: 6 Years
Maximum Age: 12 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Respiratory Morbidity | maximum symptom days in the prior 2 weeks assessed at completion of home sampling visits ( Units: days scale: 0-14 days with symptoms, higher is worse | 2 weeks | 
| Lung Function | Spirometry (FEV1 percent predicted) Units: percent Scale: continuous integers, higher is better | 1 yr | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Lung function | Oscillometry (R5-20) | 1 year | 
| Lung function | Oscillometry (AX) units: cmH20 scale 0 - infinity, lower is better | 1 year | 
| Lung function | Oscillometry R5 units: cmH20 scale 0 - infinity, lower is better | 1 year | 
| Lung function | Oscillometry R5-20 units: cmH20 scale 0 - infinity, lower is better | 1 year | 
| Lung function | Oscillometry X5 units: cmH20 scale 0 - infinity, lower is better | 1 year | 
| Lung function | Oscillometry Fres units: Hz scale 0 - infinity, lower is better | 1 year | 
| Lung Function | FEV1/FVC units: percent scale: continuous integer, higher is better | 1 year | 
| Lung Function | FVC percent predicted units: percent scale: continuous integer, higher is better | 1 year | 
| Lung Function | FEF25-75 percent predicted units: percent scale: continuous integer, higher is better | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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BPD, bronchopulmonary dysplasia, children and environment, environment, bronchopulmonary dysplasia and environment, environment and children, chronic lung disease of newborn, environment and chronic lung disease of the newborn