linjc16/ctgov huggingface dataset:
Effect of Passive Smoking on Oxidative Stress and Dental Caries in Children

Study Overview
=================
Brief Summary
-----------------
The purpose of the present study was to determine the effect of passive smoking on oxidative stress and dental caries in children.A total of 180 children were included to the study as follows; 90 children exposed to passive smoking, and 90 children in the control group (unexposed controls). Also demographic data were recorded (age, gender, parental education levels, child's tooth-brushing habit and child's daily dietary sugar exposure, family income). Dental examination of children were performed and caries prevalence of the patients were recorded. Unstimulated saliva samples were collected from children. Saliva 'cotinine levels' and oxidative stress markers 'total antioxidant status' (TAS), and' total oxidant status' (TOS) were evaluated by using Enzyme-linked immunosorbent assay (ELISA). The obtained data parameters of the two groups were evaluated and comparison was performed.

Conditions
-----------------
Oxidative Stress, Dental Caries, Passive Smoking

Intervention / Treatment
-----------------
* Diagnostic Test: taking saliva samples to determine oxidative stress markers TAS and TOS


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: -Systemically healthy children Exclusion Criteria: Uncooperative children The presence of orthodontic/intraoral appliance Any disease or condition known to affect oxidative stress

Ages Eligible for Study
-----------------
Minimum Age: 6 Years
Maximum Age: 12 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| study group (passive smoking children)<br>examining for caries prevalence and taking saliva samples to determine oxidative stress markers TAS and TOS | Diagnostic Test: taking saliva samples to determine oxidative stress markers TAS and TOS<br> <br> |
| control group<br>examining for caries prevalence and taking saliva samples to determine oxidative stress markers TAS and TOS | Diagnostic Test: taking saliva samples to determine oxidative stress markers TAS and TOS<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| determining oxidative stress marker in saliva: TAS | Unstimulated saliva samples were collected from children. | 1 day (once after the dental examination)] | 
| determining oxidative stress marker in saliva: TOS | Unstimulated saliva samples were collected from children. | 1 day (once after the dental examination) | 
| determining caries prevalence | Children were examined to determine caries prevalence. | 1 day (once for dental examination) |
Functional Exploration of Cartilage in Patients With Osteoarthritis of the Knee Through MRI Sodium ( 23Na )

Study Overview
=================
Brief Summary
-----------------
Osteoarthritis is a degenerative disease of hyaline cartilage not associated with an infection or an inflammatory process that affects millions of people. The first symptoms usually appear from 40-50 years and at this point, conventional radiological tests provide diagnostic elements relatively late, poorly correlated with pain relief and providing no functional information. In this context, there is a real need for imaging techniques for early detection of osteoarthritic changes in a still reversible stage for faster support and MRI appears to be the tool of choice. Conventional proton MRI sequences already allow improved detection possibilities compared to conventional radiology and CT arthrography supplanted. They nevertheless remain insufficient to identify incipient lesions or paradoxically to the point of too advanced lesions. Due to recent technological advances, exploration MRI other nuclei such as sodium is now possible. Quantitation of sodium in the cartilage by sodium MRI allow quantifying proteoglycan loss and ultimately a gradation osteoarthritic reached. This project's main objective is to quantify the biochemical changes (sodium content) occurring at different stages of osteoarthritis defined by clinical algofunctional scores (Lequesne) and conventional radiographic scores (Kellgren and Lawrence).

Conditions
-----------------
Osteoarthritis

Intervention / Treatment
-----------------
* Other: MRI Sodium ( 23Na )


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patient with osteoarthritis Exclusion Criteria: patient with contraindication for MRI

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Osteoarthritis patient<br> | Other: MRI Sodium ( 23Na )<br> <br> |
| Placebo Comparator: Healthy volunteers<br> | Other: MRI Sodium ( 23Na )<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percentage of sodium released in osteoarthritis patient vs healthy volunteers |  | 24 hours |
Extrapulmonary Presentations of COVID-19 Patients

Study Overview
=================
Brief Summary
-----------------
An observational study about the extrapulmonary presentations of COVID-19 patients during the second wave of the pandemic.

Detailed Description
-----------------
a prospective observational study that aimed at provide an overview about the prevalence of extra-pulmonary presentation of COVID-19 during the second wave of the pandemic and Detection of the most frequent affected systems with comparison between the pulmonary and extrapulmonary presentation of COVID 19 as regard patient demographics, comorbidity and level of care needed.

Official Title
-----------------
Extrapulmonary Presentation of COVID-19 Patients During the Second Wave

Conditions
-----------------
COVID-19

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: all patient with confirmed covid 19 disease presented to our health facility during the second wave of the pandemic Exclusion Criteria: other diagnosis than covid 19 as a primary cause of presentation of the patient
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Extrapulmonary presentation for COVID-19<br>patients with confirmed covid 19 disease who primarily presented with extrapulmonary system affection | |
| pulmonary presentation for COVID-19<br>patients with confirmed covid 19 disease who primarily presented with pulmonary disease | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| extrapulmonary presentation in COVID-19 | frequency of extrapulmonary presentation inCOVID-19 second wave pandemic | Baseline presentation of confirmed cases with COVID-19 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
pulmonary, extrapulmonary presentation
Evaluation of Topical Chamomile Versus Topical Triamcinolone Acetonide in Management of Oral Lichen Planus

Study Overview
=================
Brief Summary
-----------------
Using of herbal medications as topical chamomile which has antioxidant, anti-inflammatory and anticarcinogenesis effect with little side effects is the aim for the future treatment of OLP.

Detailed Description
-----------------
Oral lichen planus (OLP) is a chronic inflammatory T cell mediated autoimmune disease that affects skin and any mucous membrane particularly oral mucosa.The patient complains of burning sensation, pain; interference with eating, swallowing and speech leading to worsening of quality of life.Oxidative stress plays a role in pathomechanism of OLP disease. Enzymatic and non- enzymatic anti-oxidants act as a physiological guard against reactive oxygen species (ROS) and cytokine-mediated toxicity.Herbal treatment is the aim of the future therapy.Chamomile has anti-oxidant , anti-inflammatory effect and accelerate healing.

Official Title
-----------------
Evaluation of Topical Chamomile Versus Topical Triamcinolone Acetonide in Management of Oral Lichen Planus

Conditions
-----------------
Oral Lichen Planus

Intervention / Treatment
-----------------
* Drug: topical chamomile


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Symptomatic OLP. Patients with no history of taking corticosteroids for the last 6 months. Patients who agree to take medication. Medically free Exclusion Criteria: Patients with oral lesions other than OLP. Lichenoid reaction . Pregnant females and lactation. Smokers

Ages Eligible for Study
-----------------
Minimum Age: 30 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: topical chamomile<br>herbal medication which has antioxidant, anti-inflammatory and anticarcinogenesis effect. | Drug: topical chamomile<br>* herbal medication which has antioxidant, anti-inflammatory and anticarcinogenesis effect<br>|
| Active Comparator: Topical Triamcinolone Acetonide<br>topical triamcinolone acetonide is the gold standard treatment of oral lichen planus. | Drug: topical chamomile<br>* herbal medication which has antioxidant, anti-inflammatory and anticarcinogenesis effect<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain using Numerical rating scale | Pain measure using Numerical rating scale | 1 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| clinical sign score | Reduction in clinical sign score using Thongprasom et al | 1 month |
Psychiatric Disorder and Postoperative Morbidity in Hip and Knee Artroplasty

Study Overview
=================
Brief Summary
-----------------
It has been established that patients with psychiatric disorders tend to do worse in a surgical setting. Some types of surgery with greater impact than others, including orthopedic surgery. In our research group the investigators have shown this to be the case for hip and knee replacements within the mentioned patient category. However, the role of psychiatric disorder and use of different psychopharmacological drugs in relation to perioperative morbidity and mortality have not been thoroughly examined. The objective of this study is to shed light on the issue. Recent studies have shown that different types of psychiatric disorder influence surgical outcome differently. This emphasizes the need for specific knowledge regarding psychiatric diagnoses preoperatively. In this study around 2000 patients with or without psychiatric disorder of any kind will be studied preoperatively, which according to our previous study will include more than 200 patients receiving psychopharmacological treatment. The specifics that characterize every patient's psychiatric trades will be included in a validated questionnaire constructed for that purpose. The questionnaire is called SCL-92 and has been chosen in collaboration with Professor in Psychiatry, Rigshospitalet Anders Fink-Jensen. Preoperative information regarding their mental condition and medicine will be linked to surgical outcome in order to identify potential hazards in the perioperative period.

Official Title
-----------------
Characterization of Preoperative Psychiatric Disorder in Relation to Postoperative Morbidity in Elective Fast-Track Total Hip and Knee Arthroplasty

Conditions
-----------------
Focus is on Preoperative Psychiatric Charactarization of Elective Fast-track Hip and Knee Arthroplasty Patients

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All patients planned for elective unilateral fast-track hip or knee arthroplasty. Age > 18. Can understand and read danish. Exclusion Criteria: -
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Psychological characterization of hip and knee arthroplasty patients using the validated SCL-92 questionnaire |  | 90 days postoperatively | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Length of stay |  | 90 days postoperatively | 
| Readmissions |  | 30 and 90 days postoperatively |
Compare Vaginal Estrogen and Platelet-rich Plasma Over Women With Genitourinary Syndrome of Menopause

Study Overview
=================
Brief Summary
-----------------
The definition of Genitourinary Syndrome of Menopause (GSM) is the decline of estrogens during menopause results in symptoms and clinical signs from both systems. Estrogen and other hormones production decrease after menopause because the ovaries lose their effectiveness, leading to mucosal atrophy, reduced vaginal moisture, dysuria, urgency, recurrent infection, burning, pruritus and dyspareunia. The treatment included vaginal estrogen supplement, vaginal hyaluronic acid supplement, vaginal laser, platelet rich plasma, etc. Observational cohort study will be used for study design, and questionnaire, pelvic examination, vaginal pap smear with maturation index (MI), vaginal pH, and other methods will be used for evaluation of the effectiveness and side effects.

Official Title
-----------------
Compare the Effectiveness and Side Effects of Vaginal Estrogen and Platelet-rich Plasma Over Women With Genitourinary Syndrome of Menopause

Conditions
-----------------
Menopause, Platelet-rich Plasma, Estrogen Replacement Therapy, Vaginal Atrophy

Intervention / Treatment
-----------------
* Drug: Vaginal estrogen supplement
* Procedure: Platelet-rich plasma injection


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Women with menopause Patients with symptoms of genitourinary syndrome of menopause Exclusion Criteria: Genitourinary bleeding or infection without definitive diagnosis Coagulopathy Allergy to medication or therapy related with the treatment Chronic disease that might influence outcome Using medication that might influence outcome in 30 days Using hormone or steroid within 8 weeks

Ages Eligible for Study
-----------------
Minimum Age: 45 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Genital urinary symptoms of menopause<br>Menopause for one year, or age above 45 with symptoms of GSM | Drug: Vaginal estrogen supplement<br>* Daily vaginal estrogen supplement, then twice per week. Continue for three months.<br>Procedure: Platelet-rich plasma injection<br>* Monthly platelet-rich plasma injection for three months<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Visual analogue scale (VAS) | Changes in GSM symptoms include vaginal dryness, dyspareunia, itching, burning, dysuria | 2022/8/10-2024/2/28 | 
| Vaginal health index score (VHIS) | One of the most commonly used scores for the evaluation of vaginal elasticity, secretions, pH, the presence of petechiae on the epithelial mucosa, and hydration | 2022/8/10-2024/2/28 | 
| Female Sexual Function Index (FSFI) | A brief multidimensional scale for assessing sexual function in women. | 2022/8/10-2024/2/28 |
Efficacy and Safety Study of Bimatoprost 0.01% Alone Compared With Travoprost 0.004% and Timolol 0.5% in Subjects With Glaucoma or Ocular Hypertension

Study Overview
=================
Brief Summary
-----------------
This efficacy and safety study will evaluate LUMIGAN® .01 (bimatoprost 0.01%) alone compared to TRAVATAN Z® (travoprost 0.004%) and TIMOLOL GFS, 0.5% (timolol 0.5% ophthalmic gel forming solution) in patients who require IOP lowering therapy.

Conditions
-----------------
Glaucoma, Ocular Hypertension

Intervention / Treatment
-----------------
* Drug: bimatoprost 0.01%
* Drug: travoprost 0.004%
* Drug: timolol 0.5%
* Drug: hypromellose 0.3%


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Ocular hypertension or glaucoma that requires treatment with medication Have a best corrected visual acuity (BCVA) of 20/100 or better in both eyes Exclusion Criteria: History of LASIK, LASEK, RK, and/or PRK in the study eye(s) History of any intraocular surgery or glaucoma laser surgery in the study eye(s) within 3 months Use of topical, periorbital, intravitreal or systemic steroid within 3 months or expected use during the course of study

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: bimatoprost 0.01% and hypromellose 0.3%<br>Bimatoprost 0.01% and hypromellose 0.3% lubricant eye drops (for masking purposes) each administered to both eyes once daily for 12 weeks. | Drug: bimatoprost 0.01%<br>* Bimatoprost 0.01% administered to both eyes once daily for 12 weeks.<br>* Other names: Lumigan®;Drug: hypromellose 0.3%<br>* Hypromellose 0.3% lubricant eye drops (for masking purposes) administered to both eyes once daily for 12 weeks.<br>* Other names: GenTeal®;|
| Active Comparator: travoprost 0.004% and timolol 0.5%<br>Travoprost 0.004% and timolol 0.5% each administered to both eyes once daily for 12 weeks. | Drug: travoprost 0.004%<br>* Travoprost 0.004% administered to both eyes once daily for 12 weeks.<br>* Other names: Travatan Z®;Drug: timolol 0.5%<br>* Timolol 0.5% administered to both eyes once daily for 12 weeks.<br>* Other names: Timolol GFS;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Intraocular Pressure (IOP) in the Study Eye at 8 AM, 12 PM, and 4 PM | IOP is a measurement of the fluid pressure inside the eye. IOP of the study eye (worse eye) is measured at 8 AM, 12 PM, and 4 PM. IOP is either the average of 2 measurements, or, if a third measurement is required, the average of 3 measurements. | Week 12 at 8 AM, 12 PM, and 4 PM |
Is Cryosurgery or Curettage More Effective at Treating Seborrheic Keratoses?

Study Overview
=================
Brief Summary
-----------------
Seborrheic keratoses (SK's) are very common, but harmless skin lesions that commonly appear during adult life. Patients with seborrheic keratoses frequently desire treatment due to symptoms of itching and irritation or for cosmetic purposes. Seborrheic keratoses can be easily removed and have been treated in a number of different ways. Two of the simplest and most successful ways to remove seborrheic keratoses are cryosurgery and curettage. The investigators are conducting this study to see which of these two treatments has the best result. Approximately 24-30 people will take part in this research study at the Hershey Medical Center.

Official Title
-----------------
Is Cryosurgery or Curettage More Effective at Treating Seborrheic Keratoses?

Conditions
-----------------
Seborrheic Keratosis

Intervention / Treatment
-----------------
* Procedure: cryosurgery
* Procedure: Curettage


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: have at least 1 seborrheic keratosis on each side of his/her trunk or proximal extremities. be able to understand the consent form and evaluation of treatment questionnaire. Exclusion Criteria: Children <18 are excluded from this study based on their inability to independently complete the informed consent and research associated questionnaire.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Cryosurgery<br>One lesion on the patients' trunk or proximal extremities will be treated with cryosurgery. | Procedure: cryosurgery<br>* freezing of lesion with liquid nitrogen<br>|
| Active Comparator: Curettage<br>One lesion on one side of the patients' trunk or proximal extremities will be treated by curettage. | Procedure: Curettage<br>* the lesion will be anesthetized and destroyed with a curette.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Partial or complete resolution of treated lesion. | Follow up evaluation by a blinded physician along with the gathering of patient information via questionnaires will be obtained at the completion of the study. | 6 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
seborrheic keratoses, cryosurgery, curettage