The Realtime Detection for Prediction of Opioid Analgesic

Study Overview
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Brief Summary
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This study aimed to find a quick and timely way to predict the individual variation of efficacy of opioid analgesic during the operation and postoperative analgesia in Chinese patients undergoing elective surgeries. Methods: female patients receiving elective surgery under general anesthesia were recruited into this study. At the time of routine intravenous anesthetic induction we observe the efficacy of opioid analgesic including analgesic effect, effects on Narcotrend index, sedative effect, effects on respiratory system, and aslo effects on cardiovascular system. Then we record the consumption of of opioid analgesic during the operation and postoperative analgesia. Also we record the side effect of the opioid analgesic.

Detailed Description
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Patients with the following diseases were excluded: known history of chronic pain, psychiatric diseases or communication disorders, diabetes mellitus, severe cardiovascular diseases, kidney or liver diseases with poor hepatic function, alcohol or drug abuse, heavy smoker, pregnancy or at the lactation period.

Official Title
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Study of Prediction of Opioid Analgesic

Conditions
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Surgery, Individuality

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Aged 20-65 years Anesthesiologists (ASA) physical status I or II; Within ±20% of ideal body weight; Agreed to participate the research Exclusion Criteria: •History of chronic pain; Psychiatric diseases; Diabetes mellitus; Severe cardiovascular diseases; Kidney or liver diseases; Alcohol or drug abuse (according to the criteria of DSM-IV); Pregnancy or at lactation period; Disagree to participate to the research

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rangeability of pressure pain threshold | According to the measurement of pressure pain threshold before and after intravenous injection of opioid analgesics | 8 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rangeability of Narcotrend index | According to the measurement of Narcotrend index before and after intravenous injection of opioid analgesics | 8 months | 
| Rangeability of Ramsay Sedation Scale | According to the investigation of Ramsay Sedation Scale before and after intravenous injection of opioid analgesics | 8 months | 
| Rangeability of respiratory frequency | According to the measurement of respiratory frequency before and after intravenous injection of opioid analgesics | 8 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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sufentanil, individual variation, pain threshold, narcotrend index