Protocol of Multi-domain Attention Training

Study Overview
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Brief Summary
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This study sought to investigate the changes in attention in older adults with mild cognitive impairment after Multi-domain Attention Training .

Detailed Description
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This double-blind randomized controlled study has a 2-arm parallel group design. All subjects will be randomized by the block randomization, into intervention group (Multi-domain Attention Training, MAT), or active control group (Passive information activities, PIA). Training sessions of the MAT group are 45 minutes/day, 3 days/week, for 12 weeks (36 sessions each). The training of PIA group is the same as MAT group. The investigators constructed a rigorous MAT program adhering to the Consolidated Standards of Reporting Trials (CONSORT) reporting guidelines. The investigators expect to determine the improvement in attention function of older adults with mild cognitive impairment after using the MAT program.

Official Title
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The Development and Evaluation of Multi-domain Attention Training for Older Adults With Mild Cognitive Impairment

Conditions
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Mild Cognitive Impairment

Intervention / Treatment
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* Behavioral: Multi-domain Attention Training (MAT)
* Behavioral: Passive information activities (PIA)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Participants must endorse at least two items from a list of frequent subjective memory complaints by patient and/or an informant Objective memory impairment on neuropsychological tests of memory 1.5 SD or more below age/education norms Clinical neurologic examination by the Mini-Mental State Examination (MMSE) score of 24 or higher No impairment in personal activities of daily living (P-ADL) as determined by clinical interview with participant and family Exclusion Criteria: The clinical diagnosis of dementia was based on the DSM-IV-TR Active in another cognitive or memory-related training in the past year Comorbid medical conditions that would predispose them to imminent functional decline or cognitive impairment A diagnosis of major neurological or psychiatric illness history and/or behavioral problems that would sufficiently impair performance to make participation impossible Severe losses in vision, hearing, or communicative ability
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Multi-domain Attention Training (MAT)<br>Training sessions of the MAT group is 45 minutes/day, 3 sessions/week, for 12 weeks (36 sessions). | Behavioral: Multi-domain Attention Training (MAT)<br>* The training content emphasis three concept of attention include: intensity of attention, executive attention, and spatial orienting attention.<br>* Other names: Attention training;|
| Active Comparator: Passive information activities (PIA)<br>The training sessions of PIA is the same as MAT group (45 min/day, 3 days/week, for 12 weeks, for a total of 36 sessions). | Behavioral: Passive information activities (PIA)<br>* The active control group (Passive information activities) training content included reading online e-books and playing online games.<br>* Other names: Active control group;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in attention as measured by the Digit Span Task (DS). | The primary outcome indicators is executive attention assessed by the Digit Span Task (DS). | Change from baseline in executive attention at Immediate post-test, 3 months, 6 months after intervention. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in attention as measured by the Trail Making Test (TMT). | The secondary outcome indicator is spatial orienting attention evaluated by the Trail Making Test. | Change from baseline in spatial orienting attention at Immediate post-test, 3 months, 6 months after intervention. |