Effects of Pregabalin on Post-cesarean Pain

Study Overview
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Brief Summary
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Post-cesarean pain management is essential for early mobilization of the mother so that she becomes able to care of her newborn. There choices for postoperative analgesia include spinal, systemic, or both opioids, non-steroidal anti-inflammatory drugs (NSAIDs), local anesthetic infiltrations of the wound, or transverse abdominis plane blocks, which are determined by drug availability, regional and individual preferences, resource limitations and financial considerations. The use of opioids is associated with adverse effects such as nausea, pruritus, sedation, and occasionally respiratory depression. Pregabalin is an anticonvulsant drug structurally related to the inhibitory neurotransmitter gamma amino butyric acid, that exerts its action by binding to the α-2-δ subunit of the voltage-dependent calcium channel. It reduces the release of the excitatory neurotransmitters and inhibits the hyperalgesia and central sensitization. A recent meta-analysis demonstrated that pregabalin reduce the postoperative 24 hours cumulative opioid consumption and opioid-related adverse effects namely, vomiting and visual disturbances after surgery. Compared with the use of pregabalin doses lower than 300 mg, the use of doses higher than 300 mg even reduced opioid consumption by 35%. It is not known if pregabalin is excreted in human milk. There is a case report on the extensive excretion of pregabalin in breast milk, but with low measured concentrations in infant as a consequence of maternal exposure during breast feeding. Food and Drug Administration recommends to discontinue nursing or to discontinue pregabalin in nursing mothers. Pre-delivery single exposure to pregabalin is expected to be safe for the newborns. Up to the authors' best knowledge, this is the first clinical study on the efficacy and safety of the administration of pregabalin before cesarean delivery. We hypothesis that the preoperative administration of a single dose of pregabalin will improve the quality of postoperative analgesia after cesarean delivery. This placebo-controlled study aims to compare the effects of preoperative administrations of single oral doses of pregabalin 150 mg and 300 mg on the postoperative pain scores, cumulative patient controlled morphine consumptions, neonatal Apgar and neurologic and adaptive capacity scores (NACS), and maternal and neonatal adverse effects in parturients scheduled to elective Cesarean delivery under spinal anesthesia.

Detailed Description
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An independent investigator who will not be involved in the study will instruct the patients preoperatively about the use of patient controlled analgesia and visual analogue scale to assess the severity of postoperative pain (0 mm for no pain and100 mm for worst imaginable pain). Anaesthetic management will be standardized. Oral ranitidine 150 mg and metoclopramide 10 mg will be given the night before and on the morning of surgery, with 0.3 mol/L sodium citrate 30 mL given 15 min before induction. Ninety minutes before surgery, subjects will be allocated randomly into three groups by drawing sequentially numbered sealed opaque envelopes containing a software-generated randomization code to the placebo (n = 45), pregabalin 150 mg (n = 45) and the pregabalin 300 mg (n = 45) groups. The placebo and pregabalin capsules look identical and will be prepared by a local pharmacy. An anaesthesiologist not otherwise involved in the study and who will be blinded to treatment regimen will provide perioperative care. An independent investigator will collect perioperative data. All staff in the operating room will be unaware of patient allocation group. Maternal monitoring will include electrocardiography, non-invasive blood pressure, and pulse oximetry. Left uterine displacement will be maintained. Spinal anesthesia will be performed in all cases in sitting position at L3-L4 or L4-L5 spaces with hyperbaric bupivacaine 0.5% (12.5 mg) and fentanyl 20 µg. After the umbilical cord is clamped, a 10 IU infusion of oxytocin in 500 mL of lactated Ringer's solution will be infused. A paediatrician blinded to study group allocation will record Apgar scores at 1 and 5 min, umbilical cord blood gas analysis and NACS at 15 min, 2h, 24 and 48 h after delivery. NACS gives a maximum of 40 with a score >35 denoting vigor.The percentage of infants scoring <35 will be determined. Postoperative analgesic regime will be standardized in all patients with 12-hourly intramuscular diclofenac 75 mg started immediately at the end of surgery and morphine via patient-controlled analgesia (PCA): 1 mg bolus with an 8 minutes lockout. Postoperative nausea or vomiting will be treated with intravenous metoclopramide 10 mg as required. Statistical analysis: Based on a previous study,7 the mean postoperative cumulative morphine consumption at 24 h after caesarean delivery was 38 mg with a standard deviation of 14 mg. An a priori power analysis indicated that 45 subjects were required in each group to detect a 25% reduction in the cumulative morphine consumption at 24 h after caesarean delivery, that was assumed to have a clinically significant effect, with a type-I error of 0.0167 (0.05/3 possible comparisons) and a power of 90%. Additional patients (10%) were included for a final sample size of 150 patients to account for patient dropout during the course of the study.

Official Title
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Efficacy of Preoperative Pregabalin on the Post-caesarean Pain; a Dose-response Study

Conditions
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Uncomplicated Singleton Pregnancies

Intervention / Treatment
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* Drug: Placebo
* Drug: Pregabalin 300 mg group
* Drug: Pregabalin 150 mg group


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: spinal anesthesia elective cesarean delivery breech presentation cephalopelvic disproportion previous caesarean delivery American Society of Anesthesiologists class I and II Exclusion Criteria: communication barriers cardiovascular diseases renal diseases hepatic diseases endocrinal diseases neuropsychiatric diseases morbid obesity diabetes mellitus anaemia bleeding disorders prolonged P-R interval hypersensitivity to pregabalin receiving pregabalin receiving anticonvulsants receiving antidepressants receiving antipsychotics alcohol or drug abuse Opiates abuse benzodiazepines during the last week pregnancy-induced hypertension evidence of intrauterine growth restriction fetal compromise

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 38 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Placebo<br>receive two identical placebo capsules | Drug: Placebo<br>* Ninety minutes before surgery, the parturients receive two identical placebo capsules<br>|
| Active Comparator: Pregabalin 150 mg group<br>one capsule of pregabalin 150 mg | Drug: Pregabalin 150 mg group<br>* Ninety minutes before surgery, the parturients receive one capsule of pregabalin 150 mg and one placebo capsule<br>|
| Active Comparator: Pregabalin 300 mg group<br>two capsules of pregabalin 150 mg | Drug: Pregabalin 300 mg group<br>* Ninety minutes before surgery, the parturients receive two capsules of pregabalin 150 mg<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| cumulative patient controlled morphine consumptions | cumulative patient controlled morphine consumptions 24 hours after delivery | 24 hours after delivery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| postoperative pain scores | visual analogue scale to assess the severity of postoperative pain (0 mm for no pain and100 mm for worst imaginable pain) at rest and on movement | 1, 4, 6, 12, 24 and 48 hours after delivery | 
| neonatal Apgar scores |  | 1 and 5 min aftr delivery | 
| Neurologic and adaptive capacity scores | NACS gives a maximum of 40 with a score >35 denoting vigor.The percentage of infants scoring <35 will be determined. | at 15 min, 2h, 24 and 48 h after delivery | 
| Maternal sedation | sedation (0, alert; 1, somnolent easy to arouse; 2, somnolent difficult to arouse or asleep; 3, not arousable) | every two hours after delivery, for 48 hours after delivery | 
| Maternal nausea and vomiting | nausea and vomiting (0: no nausea; 1: nausea no vomiting; 2: nausea and vomiting), | at 24 hours after delivery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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caesarean delivery, spinal anesthesia, pregabalin, postoperative pain, morphine