Prevalence,Natural History,Prognosis Factor,QualityofLife,Health Care Consumption and Social Consequences of Symptomatic Knee and Hip Osteoarthritis in France

Study Overview
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Brief Summary
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The aim of the project is to assemble and to follow on a 10-year period a nationwide representative sample of lower limb OA patients. General objectives: To document the natural history and to identify predictive factors of the evolution and consequences of hip and knee OA in terms of pain, functional disability, structural damage, quality of life, autonomy, medical and health care use and cost of disease.

Official Title
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Knee and Hip OsteoArthritis Long Term Assessment. Prevalence, Natural History, Prognosis Factor, Quality of Life, Health Care Consumption and Social Consequences of Symptomatic Knee and Hip Osteoarthritis in France

Conditions
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Hip Osteoarthritis, Knee Osteoarthritis

Intervention / Treatment
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* Procedure: X-rays
* Biological: biological samples
* Other: medical information about osteoarthritis


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: male and female aged between 40 and 75 years symptomatic hip or knee, uni or bilateral OA with clinical diagnosis confirmed by a medical physician and satisfying ACR classification criteria Representative of prevalent cases in France at the cohort set-up time Exclusion Criteria: presence of hip or knee joint replacement surgery comorbidities severe enough to affect quality of life significantly or likely to induce a high health care consumption independently of OA an history of osteotomy Patello-femoral osteoarthritis without tibio-femoral osteoarthritis Other joint diseases of the target joints adult under legal protection or not able to consent

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Study specific procedure<br>X-rays, biological samples and medical information about osteoarthritis | Procedure: X-rays<br>* X-rays (hip and knee) every 2 years<br>Biological: biological samples<br>* biological sample (blood and urine) every 2 years<br>Other: medical information about osteoarthritis<br>* several questionnaires about pain and function (WOMAC), physical activity (MAQ), quality of life (generic SF-36 and OA specific OAKHQOL/AMIQUAL), comorbidities (FCI), mental status (MMS), heath status (GHQ 28) and health resource consumption<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quality of life, patient reported outcome measures |  | every year, up to 10 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| health care consumption |  | every year, up to 10 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cohort, Quality of life, Health resource use, Disability, Prognosis