linjc16/ctgov huggingface dataset:
Pre-Clinical Models in Gynecological Tumors A Tissue Repository

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to provide a repository for long-term storage of endometrial cancer tumor and normal tissue, ascites and serum. This material will be used in studies to better understand the molecular biology of endometrial cancer.

Detailed Description
-----------------
BACKGROUND AND RATIONALE This protocol will create a central repository for banking tumor and other tissues as well as serum from patients with uterine corpus tumors. In addition, this protocol will also serve as a central repository for serum and tissue to healthy post-menopausal and peri-menopausal controls. There will be an internal bank. The internal bank will have samples available to UNM investigators.

Official Title
-----------------
Pre-Clinical Models in Gynecological Tumors: A Tissue Repository

Conditions
-----------------
Endometrial Neoplasms, Uterine Neoplasms

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All patients undergoing hysterectomy, or who have endometrial cancer, and are under routine surveillance. Patients may have received prior hormonal, cytotoxic chemotherapy, irradiation or surgical therapy. Healthy post-menopausal and peri-menopausal women. A consent form must be signed by the patient prior to study entry. Exclusion Criteria: Study Patients: Patients who do not have primary uterine corpus tumors. Patients with less than one gram of tumor tissue available to procurement. Controls: Patients unwilling to have their medical records reviewed for height, weight, and general medical history (see attached data sheets).

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Corpus Uteri, Endometrium, Cancer
Erector Spinae Plane Block in Cardiac Surgery

Study Overview
=================
Brief Summary
-----------------
ultrasound guided bilateral erector spinae plane block will be used as adjuvant to general anaesthesia in cardiac surgery

Official Title
-----------------
Ultrasound Guided Erector Spinae Plane Block in Cardiac Surgery

Conditions
-----------------
Pain, Acute

Intervention / Treatment
-----------------
* Procedure: opioid analgesia
* Procedure: ESP block


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: elective surgery Exclusion Criteria: emergency patient refusal infection at or near catheter insertion

Ages Eligible for Study
-----------------
Minimum Age: 30 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: group A WILL RECEIVE OPOID analgesia group B will receive ESP block
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: group A<br>opioid analgesia | Procedure: opioid analgesia<br>* opioid analgesia will be used with general anaesthesia<br>|
| Active Comparator: group B<br>ESP block | Procedure: ESP block<br>* ultrasound guided ESP Block before anaesthesia induction<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| pain score | NRS will be used to assess pain | 48 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| anaesthesia consumption | cumulative anaesthesia MAC | 6 hours | 
| ultrasound guided postoperative diaphragmatic excursion | diaphragmatic movement during inspiration an expiration | 24 hours | 
| spirometric respiratory funtion |  | 24 hours |
Monitoring of Anaesthesic Depth in the Cerebral Cortex Using Bispectral Bilateral System.

Study Overview
=================
Brief Summary
-----------------
This is a prospective, observational study, aimed to establish changes of bispectral bilateral system in both cerebral hemispheres during a total intravenous anaesthesia during breast surgery in the woman. By placing two Bispectral bilateral sensors (BIS), one on both frontal lobes, and another on both parietal lobes, we wanted to evaluate differences between frontal and parietal areas, when the patient is awake and during the anaesthetic procedure.

Official Title
-----------------
Monitoring of Anaesthetic Depth at Different Locations in the Cerebral Cortex Using Bispectral Bilateral System

Conditions
-----------------
Breast Surgery

Intervention / Treatment
-----------------
* Procedure: Surgery with general anaesthesia.
* Procedure: Raw EEG


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Aged more than 18 years old. Scheduled for general anaesthesia. Agree to participate(signed inform consent). Exclusion Criteria: Neurological disease. Cognitive impairment. Egg allergy. Severe disease or condition that could potentially interfere with interpretation of tests.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Males and females with alopecia<br>Males and females with alopecia scheduled for general anaesthesia. | Procedure: Surgery with general anaesthesia.<br> <br> Procedure: Raw EEG<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Bilateral BIS values from frontal and parietal areas. |  | Bilateral BIS values will be taken at baseline, anaesthetic induction, endotracheal intubation, skin incision, mantenance of anaesthesia and in emergence from anaesthesia ( 3 hours as a maximum from baseline to emergence). | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| EEG changes at LOC (loss of consciousness) and ROC (recovery of consciousness). |  | Changes will be evaluated at induction and emergence. |
Nasal Reconstruction Using a Customized 3D-printed Nasal Stent for Congenital Arhinia

Study Overview
=================
Brief Summary
-----------------
A 7-year-old arhinia patient receives nasal reconstruction with nasal cavity reconstruction and is aided with the application of a 3D-printed nasal stent to prevent nasal cavity constriction.

Detailed Description
-----------------
After reconstruction of a nasal cavity in the maxilla by burring using a navigation system, the patient required a nasal stent to prevent stenosis. However there was no conventional stent available. A 3D-printed silicone nasal stent was custom made for the cavity and inserted.

Official Title
-----------------
Nasal Reconstruction Using a Customized 3D-printed Nasal Stent for Congenital Arhinia

Conditions
-----------------
Arhinia

Intervention / Treatment
-----------------
* Other: Customized 3D-printed nasal stent


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Single patient 7-year-old male Congenital arhinia No history of previous treatment Exclusion Criteria: -
Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Customized 3D-printed nasal stent|Silicone stent with unconventional shape, 3D-printed based on patient's computed topographical images, to exactly fit newly made nasal cavity.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Nasal cavity diameter | Change from baseline nasal cavity diameter (measured by CT sagittal section, in millimeters) | 6 months |
Early Versus Late Closure of Preventive Ileostomy

Study Overview
=================
Brief Summary
-----------------
The study is designed and performed as a prospective randomized controlled single-center study. Patients who underwent rectal resection with preventive ileostomy due to rectal cancer will be included. The study investigates the effect of reversing a temporary ileostomy after 30 vs 90 days.

Conditions
-----------------
Ileostomy, Rectal Cancer

Intervention / Treatment
-----------------
* Procedure: Deileostomy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with temporary ileostomy after rectal resection for rectal cancer Patients willing to participate in the study Exclusion Criteria: Anastomosis insufficiency detected clinically or radiologically. Patients, who are physically and mentally unfit to undergo surgery or to be followed-up

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Early closure of preventive ileostomy<br>A preventive ileostomy is closed 30 days after the primary surgery | Procedure: Deileostomy<br>* Deileostomy<br>|
| Experimental: Late closure of preventive ileostomy<br>A preventive ileostomy is closed 90 days after the primary surgery | Procedure: Deileostomy<br>* Deileostomy<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative morbidity | Patients are scored according to the Clavien-Dindo Classification of Surgical Complications. | 30 days after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hospitalization time after ileostomy closure | Hospitalization time | 30 days after surgery | 
| 30-days re-admission rate | Re-admission rate during 30 days after re-admission | 30 days after surgery | 
| Quality of life of patients after ileostomy closure | Patients quality of life is assessed with EORTC QLQ-C30 questionnaires | at 3, 6, 9 and 12 moths after surgery |
Establishing Nomograms of Penile Length and Width Throughout the Weeks of Pregnancy

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to establish nomograms of penile length and width throughout the weeks of pregnancy.

Detailed Description
-----------------
Identifying pathology of male genitalia is important. It can be an isolated pathology, or connected to disorders in other organs, as part of genetic syndromes or endocrine disorders. Micropenis is a disorder, which is important to diagnose in the womb. Micropenis is defined as a penis which is measured 2.5 standard deviation below average. It is also thinner by diameter. This finding can also be the first expression of a lethal hormonal deficiency, hence the reason for early detection by ultrasound during pregnancy. Past prenatal diagnosis ultrasound studies, measured the penis from the scrotum to the tip of the penis. Another study evaluated formalin fixated fetuses after pregnancy terminations, in which the penis was measured from the abdominal wall to the tip of the penis. To date there are no nomograms for penile length, via ultrasound measurement from abdominal wall or for penile width. The investigators assume that measuring the penis from the abdominal wall is more accurate and standard than from the end of the scrotum, which is a less definitive reference point. The investigators aim to establish nomograms of penile length throughout the weeks of pregnancy. Exceptional penile width can also point out a problem with male genitalia. Therefore the investigators wish, as well to establish nomograms of penile width.

Official Title
-----------------
Establishing Nomograms of Penile Length and Width Throughout the Weeks of Pregnancy - A Prospective Descriptive Study.

Conditions
-----------------
Micropenis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Singleton pregnancy Proper pregnancy dating Normal fetal anatomical scan Gestational age 14 to 37 weeks Women aged 18 to 50 Exclusion Criteria: Multiple pregnancy Gestational age under 14 or above 37 weeks Fetus Small or Large for gestational age Abnormal anatomical scan or women who didn't perform such scan Minors

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Penile length |  | between 14 and 37 weeks gestation | 
| Penile width |  | between 14 and 37 weeks gestation | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Penis, Micropenis, Nomograms, Ultrasound, Fetus
Impact of Periodontal Treatment on Local miRNA Expression

Study Overview
=================
Brief Summary
-----------------
To assess the impact of Fill Mouth Scaling and Root planing or Quadrant Scaling and Root planing gingival crevicular fluid (GCF) levels of miRNA 7a-5p, miRNA 21-3p, miRNA 21-5p, miRNA 100-5p, miRNA 125-5p, miRNA 200b-3p and miRNA 200b-5p and their correlation with periodontitis extent.

Detailed Description
-----------------
The patients selected for the study were divided into 2 groups: group 1 (FM-SRP), group 2 (Q-SRP). Any selected subject underwent anamnestic and periodontal examination, blood and GCF sampling. MiRNA in the GCF was extracted through a commercially available kit and then measured carrying out real-time quantitative polymerase chain reaction (RT-PCR).

Official Title
-----------------
Analysis of Gingival Crevicular Fluid miRNA Changes After Periodontal Treatment.

Conditions
-----------------
Cardiovascular Diseases, Periodontal Diseases

Intervention / Treatment
-----------------
* Other: changes of gingival crevicular fluid miRNA


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Presence of at least 15 teeth CP with a minimum of 40% of sites with a clinical attachment level (CAL) ≥2mm and probing depth (PD) ≥4mm; Presence of at least ≥2 mm of crestal alveolar bone loss verified on digital periapical radiographs Presence of ≥40% sites with bleeding on probing (BOP) Exclusion Criteria: Intake of contraceptives Intake of immunosuppressive or anti-inflammatory drugs throughout the last three months prior to the study Status of pregnancy or lactation Previous history of excessive drinking Allergy to local anaesthetic Intake of drugs that may potentially determine gingival hyperplasia such as Hydantoin, Nifedipine, Cyclosporin A or similar drugs.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Q-SRP<br>Evaluation of changes of gingival crevicular fluid miRNA | Other: changes of gingival crevicular fluid miRNA<br>* Evaluation of changes of gingival crevicular fluid miRNA after periodontal treatment<br>|
| FM-SRP<br>Evaluation of changes of gingival crevicular fluid miRNA | Other: changes of gingival crevicular fluid miRNA<br>* Evaluation of changes of gingival crevicular fluid miRNA after periodontal treatment<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical attachment level reduction | evaluation of millimeters reduction of clinical attachment level (CAL) after periodontal therapy | 1-year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Periodontitis, GCF
Levosimendan Versus Milrinone in Off Pump CABG Surgery

Study Overview
=================
Brief Summary
-----------------
To compare the efficacy of Levosimendan versus Milrinone in supporting hemodynamics during off-pump coronary artery bypass grafting surgery in patients with low ejection fraction.

Detailed Description
-----------------
The major challenge during off-pump coronary artery bypass graft surgery is to maintain optimum hemodynamics by optimizing the intravascular volume and by using some inotropes. However, conventional inotropes such as beta-agonists are associated with tachycardia and arrhythmia which increase myocardial oxygen demand. Levosimendan is an inodilator which exerts its positive inotropic effect by enhancing the sensitivity of troponin C to calcium without increasing intracellular calcium concentration. Levosimendan also decreases the systemic vascular resistance, so, it increases the cardiac output without increasing myocardial oxygen consumption. This study aims to compare the efficacy of Levosimendan versus Milrinone in supporting hemodynamics during off-pump coronary artery bypass grafting surgery in patients with low ejection fraction.

Official Title
-----------------
Levosimendan Versus Milrinone to Support Hemodynamics During Off Pump Coronary Artery Bypass Grafting Surgery in Patients With Poor Ejection Fraction

Conditions
-----------------
Hemodynamics

Intervention / Treatment
-----------------
* Drug: Levosimendan
* Drug: Milrinone


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Elective off-pump coronary artery bypass grafting surgery. ejection fraction < 50% Exclusion Criteria: Patients with severe renal impairment or renal failure. Patients on mechanical support (intra-aortic balloon pump)

Ages Eligible for Study
-----------------
Minimum Age: 30 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Levosimendan<br>Intraoperative infusion of Levosimendan | Drug: Levosimendan<br>* Intraoperative infusion of Levosimendan<br>|
| Active Comparator: Milrinone<br>Intraoperative infusion of Milrinone | Drug: Milrinone<br>* Intraoperative infusion of Milrinone<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mean blood pressure |  | Intraoperative | 
| Consumption of other inotropes |  | Intraoperative | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Levosimendan, Milrinone, Off-pump, Coronary
Evaluation of the Physicians and Patients Experience of Fetal Scalp Sampling

Study Overview
=================
Brief Summary
-----------------
During labor, fetal scalp sampling is performed if the CTG registration is abnormal. The test is performed with the woman in the supine position and is generally described as a difficult and cumbersome procedure.

Detailed Description
-----------------
Women who were subjected to fetal scalp sampling are asked to fill in a questionnaire within 24 hours after delivery. The questionnaire deals with how the woman experienced the testing procedure. Physicans who performed the test are asked to fill in a questionnaire within 24 hours after delivery. The questionnaire deals with how the physician experienced the testing procedure.

Conditions
-----------------
Questionnaire, Fetal Scalp Sampling

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: fetal scalp sampling during labor Exclusion Criteria: non-proficiency in the Swedish language

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patient<br> | |
| Physcician<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
fetal scalp sampling, experience questionnaire