Bacterial Reduction and Post Operative Endodontic-pain Using Different Kinematics

Study Overview
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Brief Summary
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This study was conducted to compare the antibacterial effect and degree of postoperative pain of single rotary and reciprocating file systems during endodontic therapy

Detailed Description
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Introduction: Instrumentation kinematic is one of the many aspects of shaping files that underwent heavy development through the last decade. The impact of the type of motion used to drive shaping instruments was heavily studied but mostly in-vitro. More randomized clinical trials are needed to achieve a reliable body of data concerning the issue. Aim: This study aimed to evaluate the effect of varying shaping files' kinematics on bacterial reduction, post-operative pain and the incidence of flare-ups. Methods: Necrotic, asymptomatic, single-rooted mandibular premolars with single canals were used in the study, where 46 patients were randomly allocated to two groups. In the first group, WaveOne Gold was used for mechanical preparation while One Shape was used in the second group. Samples were taken preoperatively (S1) and after chemomechanical preparation (S2). Bacterial reduction was evaluated and compared between both groups via culturing technique and quantitative analysis by real-time polymerase chain reaction (qPCR). Post-operative pain and the incidence of flare-ups were also evaluated using the visual analog scale (VAS) method.

Official Title
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Bacterial Reduction and Post Operative Pain After Cleaning and Shaping of Root Canals With Single File Systems Used in Different Kinematics

Conditions
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Root Canal Infection

Intervention / Treatment
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* Other: root canal shaping


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: mandibular premolars single rooted single canalled necrotic pulps asymptomatic apical periodontitis Exclusion Criteria: gross caries root/crown fracture sinus tract swelling intake of antibiotics within previous 3 months pain with percussion

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: The trial design is a prospective, parallel, randomized with an allocation ratio (1:1), double-blinded, single-center clinical trial
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: rotation<br>root canal preparation performed using rotating instruments | Other: root canal shaping<br>* root canal treatment<br>|
| Active Comparator: reciprocation<br>root canal preparation performed using reciprocating instruments | Other: root canal shaping<br>* root canal treatment<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| bacterial reduction | pre-instrumentation and post-instrumentation bacterial cultures to detect change in bacterial count after root canal instrumentation with the different kinematics | up to 1 hour | 
| post operative pain | Visual analogue scale from 0-100 where 0 is the lowest and 100 is the highest | after the treatment visit by 24 hours | 
| post operative pain | Visual analogue scale from 0-100 where 0 is the lowest and 100 is the highest | after the treatment visit by 48 hours | 
| post operative pain | Visual analogue scale from 0-100 where 0 is the lowest and 100 is the highest | after the treatment visit by 72 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Reciprocation, Kinematics, Bacterial reduction, post-operative pain, endodontic flare-ups