Use of Injectable-platelet-rich-fibrin (I-PRF) to Thicken Gingival Phenotype

Study Overview
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Brief Summary
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The main objective of this study is to investigate whether the for individuals with thin gingival thickness who are susceptible to gingival recession, the investigators will use i-PRF with microneedle to increase gingival thickness without the need for surgical procedures

Detailed Description
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Due to the thin gingival phenotype, gingival recession is a problem. The investigators aimed to increase the gingival thickness using i-PRF with microneedle without considering surgical procedures, considering the positive effects of platelet concentrations on revascularization and wound healing in individuals with bone defect, fenestration and gingival thickness which are prone to gingival recession .

Official Title
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New Approach to Increasing Gingival Thickness in Individuals With Fine Gingival Phenotype:Injectable Platelet Rich Fibrin (I-PRF)

Conditions
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Periodontoclasia, Gingiva; Injury, Condition, Blood Clot, Gingiva Disorder

Intervention / Treatment
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* Other: I-PRF


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Never smokers Had no history of systemic disease Aged ≥18 years old Exclusion Criteria: Patients with a history of diabetes mellitus or systemic disease Patients who were under any medication that was known to influence periodontal tissues Patients with hormonal changes such as pregnancy or lactation Toothless individuals Patients who were clotting disorders

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Blinded, Parallel group, Randomized Controlled Trial
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: I-PRF<br>Venous blood will be taken from the patient every session and I-PRF will be created in the centrifuge.I-PRF injected on one side of bilateral thin gingival thickness.Apply once a week and one month after the end of the injections, the patient will be called to the control. | Other: I-PRF<br>* Venous blood will be taken from the patient every session and I-PRF will be created in the centrifuge.I-PRF injected on one side of bilateral thin gingival thickness.Microneedle application plus I-PRF injected on the other side in patients with bilateral region with thin gingival phenotype.Apply once a week and one month after the end of the injections, the patient will be called to the control.<br>* Other names: I-PRF and Microneedling;|
| Active Comparator: I-PRF and Microneedling<br>Venous blood will be taken from the patient every session and I-PRF will be created in the centrifuge.Microneedle application plus I-PRF injected on the other side in patients with bilateral region with thin gingival phenotype.Apply once a week and one month after the end of the injections, the patient will be called to the control. | Other: I-PRF<br>* Venous blood will be taken from the patient every session and I-PRF will be created in the centrifuge.I-PRF injected on one side of bilateral thin gingival thickness.Microneedle application plus I-PRF injected on the other side in patients with bilateral region with thin gingival phenotype.Apply once a week and one month after the end of the injections, the patient will be called to the control.<br>* Other names: I-PRF and Microneedling;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Gingival thickness (mm) | Change in clinical measures of gingival thickness | 2 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Plaque Index (PI) | Change in clinical measures of gingival parameters | 2 months | 
| Gingival Index (GI) | Change in clinical measures of gingival parameters | 2 months | 
| Bleeding on probing (BOP) | Change in clinical measures of gingival parameters | 2 months | 
| Clinical attachment level (CAL) | Change in clinical measures of gingival parameters | 2 months | 
| Probing pocket depth (PD) | Change in clinical measures of gingival parameters | 2 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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PRF, I-PRF, Microneedle, Gingival Thickness, Injectable-Platelet-Rich-Fibrin, Platelet Rich Fibrin