Recovery After Total Intravenous Anesthesia With Ketofol Versus Mixture of Ketofol and Lidocaine for Short Pediatric Surgery

Study Overview
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Brief Summary
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Two hundred children aged 1-12 years undergoing short surgery will be randomized into two groups. Ketofol will be used for induction and maintenance of anesthesia in group l. .Ketofol with lidocaine will be prepared for group ll. A reducted McFarlan infusion dose will be used. Extubating time, duration of anesthesia, length of stay in post-anesthesia care unit (PACU) will be recorded.

Detailed Description
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Aim of the research: In this study investigators want to examine the effectiveness of the use of ketofol and a mixture of ketofol and lidocaine on the total consumption of opioids and on the postoperative recovery of pediatric patients. Investigators will evaluate the safety, efficacy, and outcomes of the anesthesia procedure with respect to the administration of different anesthetics, specific pharmakocinetic profiles and compare the length of recovery between patients in two groups. Including criteria: children aged 1 to 12 years who underwent short surgery (up to 60 min). Primary and secondary outcome measures: The primary outcome of this study will be extubation time and the secondary outcome will be time spend in PACU. Description of the study: Each subject included in the study will be given general anesthesia with ketofol or ketofol and lidocaine, with the addition of fentanyl. After 20 s the LMA will be placed. Maintenance of anesthesia will be performed using an air / oxygen mixture (50% / 50%) and an infusion of ketofol or ketofol and lidocaine. Ketofol will be prepare in a ratio of 1: 4 for induction and 1: 7 for maintenance. The same mixtures of ketofol will be added 1 ml of 2% lidocaine for the second group of patients. After extubation, patients will be transferred to the PACU.

Official Title
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TIVA With Ketofol Versus Lidoketofol for Short-term Anesthesia on Pediatric Patients; Effects on Recovery

Conditions
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Surgical Procedure, Unspecified

Intervention / Treatment
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* Drug: ketamine, propofol
* Drug: ketamine, propofol, lidocaine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: surgical procedures max 60 min ASA I and II Exclusion Criteria: ASA > II surgical procedures longer than 60 min

Ages Eligible for Study
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Minimum Age: 1 Year
Maximum Age: 12 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Pediatric anesthesia with ketofol<br>ketamine, propofol | Drug: ketamine, propofol<br>* anesthesia with ketofol in pediatric surgery<br>|
| Experimental: Pediatric anesthesia with ketofol plus lidocaine<br>ketamine, propofol, lidocaine | Drug: ketamine, propofol, lidocaine<br>* anesthesia with ketofol plus lidocaine in pediatric surgery<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Effect of TIVA With Ketofol and Ketofol Plus Lidocaine on Extubation Time in Children |  | up to 600 seconds | 
| Effect of TIVA With Ketofol and Ketofol Plus Lidocaine on Length of Stay in the PACU |  | up to 40 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Effect of TIVA With Ketofol and Ketofol Plus Lidocaine on Total Opioid Consumption |  | up to 60 minutes |