linjc16/ctgov huggingface dataset:
Diagnostic of Infections Following Major Abdominal Surgery and Burn Injury

Study Overview
=================
Brief Summary
-----------------
This study was designed to investigate, if new biomarkers may improve the early diagnostic of infections following major abdominal surgery and severe burn injuries.

Official Title
-----------------
Impact of Biomarkers for Early Diagnostic of Infections Following Major Abdominal Surgery and Severe Burn Injuries

Conditions
-----------------
Third Degree Burn, Second Degree Burn

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients with major abdominal surgery (e.g. gastrectomy, hemi-/colectomy, resection of sigma or rectum, resection of liver, esophagectomy) patients following severe burn injury (burn surface area >= 15%) age >= 18 years informed consent Exclusion Criteria: no informed consent emergency surgery immunocompromising diseases (e.g. HIV+, AIDS, Lymphoma or NonHodgkin-Lymphoma, Autoimmune-Diseases) pre-existing liver or renal failure chronic therapy with corticoids

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| major abdominal surgery<br>The investigators compare the levels of biomarkers in patients with and without complications in the early postoperative course following major abdominal surgery | |
| severe burn injury<br>The investigators compare levels of biomarkers within the first 20 days in patients with and without complications following severe burn injury | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| rate of infections |  | day 28 post intervention | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
major abdominal surgery, severe burn injury, infection, diagnostic
Pharmacokinetic Interaction and Safety Between NVP-1203-R1 and NVP-1203-R2

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to compare the pharmacokinetics and safety between NVP-1203-R1 and NVP-1203-R2

Detailed Description
-----------------
pharmacokinetics and safety between NVP-1203-R1 and NVP-1203-R2

Official Title
-----------------
A Phase I Clinical Trial to Evaluate the Pharmacokinetic Interaction and Safety Between NVP-1203-R1 and NVP-1203-R2 in Healthy Adult Subjects

Conditions
-----------------
Healthy

Intervention / Treatment
-----------------
* Drug: NVP-1203-R1
* Drug: NVP-1203-R2
* Drug: NVP-1203-R1 and NVP-1203-R2


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: healthy adult subjects who signed informed consent Exclusion Criteria: Subjects has a history of allergy reaction of study drug ingredient Subjects participated in another clinical trial within 6 months prior to administration of the study drug Inadequate subject for the clinical trial by the investigator's decision

Ages Eligible for Study
-----------------
Minimum Age: 19 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: NVP-1203-R1<br>Drug: NVP-1203-R1 1 tablet, oral dosing | Drug: NVP-1203-R1<br>* 1 tablet, Single oral dosing<br>* Other names: NVP-1203-R1(A);|
| Experimental: NVP-1203-R2<br>Drug: NVP-1203-R2 1 tablet, oral dosing | Drug: NVP-1203-R2<br>* 1 tablet, Single oral dosing<br>* Other names: NVP-1203-R2(E);|
| Experimental: NVP-1203-R1 and NVP-1203-R2<br>Drug: NVP-1203-R1 1 tablet and NVP-1203-R2 1 tablet co-administration(oral dosing) | Drug: NVP-1203-R1 and NVP-1203-R2<br>* NVP-1203-R1,1 tablet and NVP-1203-R2, 1 tablet, co-administration, single oral dosing<br>* Other names: NVP-1203-R1(A) and NVP-1203-R2(E);|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pharmacokinetic interaction | Area under the curve (AUC) | 0hours - 24hours |
Extensive Circumferential Partial Thickness Sclerectomy in Nanophthalmic Eyes

Study Overview
=================
Brief Summary
-----------------
Purpose: To describe an extensive scleral excision technique to treat or prevent uveal effusion in nanophthalmic eyes. Design: Prospective interventional case series. Methods: Setting: Institutional. Patient Population: Consecutive patients with nanophthalmos were operated on by one surgeon. Intervention Procedure: A single, 90% thickness scleral window extending from immediately behind the extraocular muscle insertions to the vortex veins was performed for 3 and 1/4 quadrants as a circumferential strip. Main Outcome Measure: Resolution or prevention of uveal effusion.

Detailed Description
-----------------
Surgical Technique All surgeries were performed under general anesthesia by one surgeon (AMM). Because the majority of the patients were young with narrow palpebral fissures and very deep set globes in small orbits, special surgical techniques were required. Lateral canthotomy was performed on all patients except for the first. Limbal 360o conjunctival peritomy was followed by securing of each rectus muscles with a modified muscle hook and 2-0 silk suture. Scleral dissection was performed from immediately behind to the muscle insertions posterior to the vortex veins. A 90% depth scleral window was excised over 3 and ¼ quadrants, excluding 3/4 of the superior temporal quadrant to avoid damaging the superior oblique muscle.

Official Title
-----------------
Extensive Circumferential Partial Thickness Sclerectomy in Nanophthalmic Eyes

Conditions
-----------------
Nanophthalmos

Intervention / Treatment
-----------------
* Procedure: sclerectomy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: nanophthalmos - Exclusion Criteria: None -
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Interventional Model Description: surgery
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: sclerectomy|scleral flap|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| resolution of uveal effusion | disappearence of uveal effusion by OCT | 1 month | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
uveal effusion
Increasing Workplace Physical Activity in Sedentary Office Workers

Study Overview
=================
Brief Summary
-----------------
Purpose: The purpose of this study is to implement and evaluate a randomized controlled trial in sitting office workers to reduce sitting time through the use of motorized and non-motorized sit/stand workstations as well as a walking intervention. Hypotheses: Compared to the control group, total physical activity will be higher in the standing and walking intervention groups. The combined standing and walking group will have higher total physical activity than the other three groups. Compared to the control group, the fitness and health outcomes will be improved for the standing and walking groups.

Official Title
-----------------
Increasing Workplace Physical Activity in Sedentary Office Workers

Conditions
-----------------
Sit-Stand Workstations

Intervention / Treatment
-----------------
* Behavioral: Stand
* Behavioral: Move
* Behavioral: Stand and Move


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Sedentary adults who use a single computer workstation for the majority of their workday Work full time (at least 35 hours per week) Must have ability to safely begin a standing and/or walking protocol with no adverse side effects Exclusion Criteria: Musculoskeletal or joint problems Severe autoimmune conditions Varicose veins that may cause pain Women who are pregnant

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Stand<br> | Behavioral: Stand<br>* Stand at least half of the workday at work.<br>|
| Experimental: Move<br> | Behavioral: Move<br>* Increase movement time at work. Move more by making small changes (walking meetings, take stairs, etc).<br>|
| Experimental: Stand and Move<br> | Behavioral: Stand and Move<br>* Increase standing time to half of workday (4h) and increase movement time at work.<br>|
| No Intervention: General Wellness<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Total physical activity |  | 6-months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fasting blood glucose |  | 6-months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Sit-Stand Workstations, Increase Workplace Physical Activity
Toothbrushing and Ventilator-associated Pneumonia

Study Overview
=================
Brief Summary
-----------------
The hypothesis is that adding the toothbrushing to the oral care with clorhexidine 0.12% could be reduce the incidence of ventilator-associated pneumonia due to that oral cavity may be an important reservoir of pathogens that could cause pneumonia.

Official Title
-----------------
Efficacy of Toothbrushing for the Prevention of Ventilator-associated Pneumonia

Conditions
-----------------
Ventilator Associated Pneumonia

Intervention / Treatment
-----------------
* Device: Toothbrushing with a manual brush


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: mechanical ventilation Exclusion Criteria: edentulous

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Toothbrushing with a manual brush<br>Toothbrushing with a manual brush | Device: Toothbrushing with a manual brush<br>* Toothbrushing with a manual brush<br>|
| No Intervention: No toothbrushing<br>no toothbrushing | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prevention of ventilator-associated pneumonia |  | 60 days |
Horizontal Ridge Augmentation of the Mandible Autogenous Block Grafts

Study Overview
=================
Brief Summary
-----------------
20 subjects presenting with horizontal mandibular ridge width less than 5 mm were selected and randomly divided two groups (10 in each group). the first group received interpositional block grafts (harvested from the chin and ramus) covered with Platelet-rich fibrin membrane. the second group received onlay block grafts (harvested from the chin and ramus) and covered with Platelet-rich fibrin membrane. the grafts are left for 4 months. the alveolar ridge width dimensions is then measured using radiographic analysis using cone-beam computed tomography scans

Official Title
-----------------
Horizontal Ridge Augmentation of the Mandible Using Interpositional Autogenous Block Grafts Versus Onlay Block Grafts; Randomized Controlled Clinical Trial

Conditions
-----------------
Horizontal Ridge Deficiency, Block Graft

Intervention / Treatment
-----------------
* Procedure: ridge split interpositional block graft
* Procedure: decortication Onlay block graft


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients of both sexes with a minimum vertical bone height above the inferior alveolar canal of 10mm in the edentulous region. Patients should have ridge thickness less than 5mm measured 2mm from the alveolar crest Patients should be free from any systemic disease that may affect normal healing of bone, and predictable outcome. Exclusion Criteria: Patients with any systemic disease that may affect normal bone healing. Patients with drug allergies, drug or alcohol abuse, periodontal diseases or poor oral hygiene

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Interpositional block graft<br>ridge split interpositional block graft | Procedure: ridge split interpositional block graft<br> <br> |
| Active Comparator: Onlay block graft<br>decortication onlay block graft | Procedure: decortication Onlay block graft<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| alveolar ridge width gained | radiographic analysis following ridge augmentation using Cone beam computed tomography | 4 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| patient morbidity following the surgical procedure | pain value on pain scale | 14 days |