Beetroot Juice - Effects on Performance in Chronic Obstructive Pulmonary Disease Patients

Study Overview
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Brief Summary
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The purpose is to evaluate exercise performance in patients with Chronic Obstructive Pulmonary Disease (COPD) after supplementing with higher doses of dietary NO3-, compared to previous studies, as beetroot juice for seven days. The secondary purpose is to evaluate oxygen consumption of submaximal cycling, amendments in blood pressure, and physical activity level.

Detailed Description
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The purpose is to evaluate exercise performance in patients with Chronic Obstructive Pulmonary Disease (COPD) using the 6-minute walk test (6MWT) after supplementing with higher doses of dietary NO3- compared to previous studies, as beetroot juice for seven days. The secondary purpose is to evaluate oxygen consumption of submaximal cycling, amendments in blood pressure, and physical activity level.

Official Title
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Beetroot Juice - Effects on Performance in Chronic Obstructive Pulmonary Disease Patients

Conditions
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Chronic Obstructive Pulmonary Disease Moderate

Intervention / Treatment
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* Dietary Supplement: Dietary beetroot juice


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Moderate-severe Chronics Obstructive Pulmonary Disease (COPD) (FEV1 <80% of predicted). Exclusion Criteria: Smoking, failure to complete physical testing, on-going participation in rehabilitation programs, pacemaker or use of nicotine products, oxygen mask, beta blockers, antibacterial mouthwash, chewing gum or stomach-neutralizing medicine during the intervention.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Placebo ---> Dietary beetroot<br>Placebo was administrated in the first period of the cross-over trial, while the intervention beverage Dietary Beetroot juice was administrated in the second period of the trial. The placebo: was an NO3- negligble drink from James White Drinks England (Beet-it), which was otherwise similar to the dietary beetroot juice in nutrient composition, smell and appearance. Dose: 2x70 mL consumed twice a day for six days. Intervention beverage, Dietary beetroot juice:Consumed as beetroot juice from James White Drinks England (Beet-it) and contained 300 mg dietary nitrate. Dose: 2x70 mL consumed twice a day for six days. | Dietary Supplement: Dietary beetroot juice<br>* Consumed as concentrated beetroot juice from James White Drinks England (Beet-it) and contained 300 mg dietary nitrate. Dose: 2x70 mL consumed twice a day for six days.<br>|
| Experimental: Dietary beetroot juice --> Placebo<br>The intervention beverage Dietary beetroot juice was administrated in the first period of the cross-over trial, while placebo was administrated in the second period of the trail Intervention beverage, Dietary beetroot juice:Consumed as beetroot juice from James White Drinks England (Beet-it) and contained 300 mg dietary nitrate. Dose: 2x70 mL consumed twice a day for six days. The placebo: was an NO3- negligble drink from James White Drinks England (Beet-it), which was otherwise similar to the dietary beetroot juice in nutrient composition, smell and appearance. Dose: 2x70 mL consumed twice a day for six days. | Dietary Supplement: Dietary beetroot juice<br>* Consumed as concentrated beetroot juice from James White Drinks England (Beet-it) and contained 300 mg dietary nitrate. Dose: 2x70 mL consumed twice a day for six days.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Physical performance on 6-min walk test (6MWT) |  | 6 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood Pressure |  | At baseline and 150 minutes after consumption of beverages | 
| Plasma Nitrite concentration |  | Baseline, 150 and 210 minutes after consumption of beverages | 
| Oxygen consumption during submaximal cycling |  | Two trials of 6 minutes duration (10 min break between trials) | 
| Physical activity level | Measured all intervention days except on the day of testing | Six days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Dietary nitrate, Physical performance, Blood pressure, Nitrite, Exercise