Effect of Immersive Virtual Reality Exergames in Patients With Parkinson's Disease

Study Overview
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Brief Summary
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The study aimed to investigate the effect of applying cognitively challenging exergames using fully immersive virtual reality in patients with Parkinson's disease.

Detailed Description
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It has been reported that dual-task training involving both cognitive and physical functions helps improve walking speed during dual-task performance without increasing the fall risk in patients with Parkinson's disease (PD). Compared with conventional physical therapy, there are studies that dual-task training significantly improved walking speed and stride in PD patients. In addition, a systematic review study has been reported that it helps to improve balance and cognitive function when dual-task training is performed for patients with neurological diseases including Parkinson's disease. Virtual reality is expected to promote functional recovery in patients with neurological disorders in terms of providing an enriched environment, goal-directed tasks and repetition, and inducing interest and motivation. Therefore, the study aimed to investigate the effect of applying cognitively challenging exergames using fully immersive virtual reality in patients with PD.

Official Title
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Effect of Cognitively Challenging Exergames Using Fully Immersive Virtual Reality in Patients With Parkinson's Disease: A Pilot Study

Conditions
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Parkinson Disease

Intervention / Treatment
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* Device: Virtual reality exergames


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Clinically diagnosed as idiopathic Parkinson's disease Modified Hoehn & Yahr stage 2, 2.5, or 3 Exclusion Criteria: Moderate to severe cognitive dysfunction with Mini-mental State Examination score < 19 Severe dyskinesia or severe on-off phenomenon Plan to adjust medication at the time of screening Other brain diseases such as stroke, brain tumor, etc History of seizure Vestibular disease or paroxysmal vertigo Other comorbidities that make it difficult to participate in this study

Ages Eligible for Study
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Minimum Age: 19 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Virtual reality exergames<br>Cognitively challenging exergames using fully immersive virtual reality with a head-mounted display (HTC Vive; HTC Co., New Taipei City, Taiwan) | Device: Virtual reality exergames<br>* A total of 10 sessions were held for 30 minutes, 2 to 3 times a week for exergames using fully immersive virtual reality under the assistance of an occupational therapist.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cognitive dual-task interference (%) in Timed-up & go test |  | at study completion, an average of 1 month | 
| Physical dual-task interference (%) in Timed-up & go test |  | at study completion, an average of 1 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Timed-up & go test (sec): single task |  | at study completion, an average of 1 month | 
| Timed-up & go test (sec): cognitive dual-task |  | at study completion, an average of 1 month | 
| Timed-up & go test (sec): physical dual-task |  | at study completion, an average of 1 month | 
| The Unified Parkinson's Disease Rating Scale | The higher the score, the more negative the result | at study completion, an average of 1 month | 
| Berg balance scale | The higher the score, the more positive the result | at study completion, an average of 1 month | 
| Stroop test |  | at study completion, an average of 1 month | 
| Trail making test |  | at study completion, an average of 1 month | 
| Digit span test |  | at study completion, an average of 1 month | 
| New Freezing of Gait Questionnaire (NFOGQ) |  | at study completion, an average of 1 month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Parkinson's disease, Virtual reality, Exergame