Study Evaluating the Olfactory Recovery of Anosmia Post COVID-19 by Olfactory Rehabilitation Assisted by Web-application

Study Overview
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Brief Summary
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Anosmia is a symptom present in 40 to 80% of patients and usually only lasts 1 to 2 weeks. However, in nearly one in five patients, it can last beyond or even several months with consequences in terms of undernutrition and depression. However, olfactory rehabilitation is a technique validated in post-infectious anosmia since 2014 and recommended by international learned societies to accelerate recovery with nearly 63% improvement in anosmia In the context of the health crisis linked to the coronavirus, approximately 1 million French people will have persistent anosmia following an infection with COVID-19. A web-application to support the olfactory coaching of anosmic patients and help with follow-up seems relevant to promote recovery and the proper conduct of this coaching. covidanosmie.fr is a web application dedicated to olfactory rehabilitation, accessible free of charge.

Official Title
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Prospective Study Evaluating the Olfactory Recovery of Anosmia Post COVID-19 by Olfactory Rehabilitation Assisted by Web-application

Conditions
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Covid19

Intervention / Treatment
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* Device: Web-application


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Post-COVID anosmia lasting more than 1 month Consent to the use of data via the application Exclusion Criteria: Other causes of anosmia than COVID Contraindication to olfactory coaching (allergy to one of the aromatic oils) Minor

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| users<br>Users of web-application | Device: Web-application<br>* support for olfactory coaching consisting of the inhalation of fragrant essential oils.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluation of the rate of patients presenting an improvement in their anosmia | Number of patients with an improvement in anosmia (increase of at least 1 point on the visual analogue scale 0-10) on the number of users | 16 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluation of the time until recovery of at least 1point in 10 (Visual Analog Scale) from anosmia, | Time between the date of first use of the application and the date of recovery of at least one point of anosmia | 16 weeks | 
| Assessment of the duration of anosmia | Time between the date of diagnosis or onset of anosmia and the date of final recovery | 16 weeks | 
| Evaluation of the recovery of at least one point in 10 (Visual Analog Scale) depending on the oils | Evolution of the VAS according to the different oils, proportion of patients with an increase of at least 1 point in anosmia on a visual analog scale (from 0 no smell to 10 normal smell) of each oil | 16 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Web-application, Anosmia, COVID-19, coaching