The Quality of Recovery After General Anesthesia With Desflurane and Sevoflurane in Endoscopic Ureteral Lithotripsy

Study Overview
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Brief Summary
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The good quality of recovery after general anesthesia is one of goals for short procedures and ambulatory surgeries. The study's objective was to compare the quality of recovery after general anesthesia with desflurane and sevoflurane with laryngeal mask airway for endoscopic ureteral lithotripsy.

Detailed Description
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This is a randomized controlled trial. There were 60 cases of endoscopic ureteral lithotripsy under general anesthesia with laryngeal mask airway were enrolled. All cases were randomly divided into two group (desflurane or sevoflurane). Each group had 30 cases. Primary outcome was time to awakening. Secondary outcomes were time to wash-out of volatile anesthetics, time to extubation, irritation after awakening, and modified Aldrete score. Statistical analysis was performed by using Kaplan-Meieir curve and log-rank test for time to adequate depth of anesthesia and time to awakening; t-test for time to wash-out of volatile anesthetics; chi-square test for depth of anesthesia by PRST score, irritation after awakening and Aldrete score; Fisher test for adverse effects of volatile anesthetics. The research was approved by Gia Dinh People Hospital ethics committee

Official Title
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The Quality of Recovery After General Anesthesia With Desflurane and Sevoflurane in Endoscopic Ureteral Lithotripsy

Conditions
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Anesthesia

Intervention / Treatment
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* Other: Other


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All eligible subjects who underwent endoscopic ureteral lithotripsy under general anesthesia ASA I and II Exclusion Criteria: Contraindication to laryngeal mask airway. Indication for conversion to tracheal intubation during surgery. History of malignant hyperthermia. Pregnancy. Obese (BMI >25 kg/m2). Substances abuse.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: D: maintain anesthesia with desflurane<br>D: maintain anesthesia with Suprane® (Desflurane) at 6%. Volatile concentration was titrated according to end-tidal MAC to maintain 0.7-1.3 MAC using end-tidal monitor of Dräger Primus anesthesia machine. | Other: Other<br>* Compare time to awakening and quality of recovery after general anesthesia between two groups.<br>|
| Other: S: maintain anesthesia with sevoflurane.<br>S: maintain anesthesia with Sevorane® (Sevoflurane) at 2%. Volatile concentration was titrated according to end-tidal MAC to maintain 0.7-1.3 MAC using end-tidal monitor of Dräger Primus anesthesia machine. | Other: Other<br>* Compare time to awakening and quality of recovery after general anesthesia between two groups.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time to awakening | Time required for awakening | After stopping volatile anesthetics to patient awakening, up to 30 minutes. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time to wash-out of volatile anesthetics | Time required for washing out volatile anesthetics | After stopping volatile anesthetics to complete wash-out of volatile anesthetics, up to 30 minutes | 
| Time to extubation | Time required for successful extubation. | After stopping volatile anesthetics to readiness for extubation, up to 30 minutes | 
| Irritation after awakening | Aono score >2 | After awakening to eligible discharge, up to 2 hours. | 
| Adverse effects of volatile anesthetics | Hypotension, cough, nausea and vomitting. | After providing volatile anesthetics until they were stopped, up to 90 minutes |