Comparing Intubating Conditions Using Succinylcholine or Rocuronium for Rigid Bronchoscopy

Study Overview
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Brief Summary
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Succinylcholine is commonly used for neuromuscular relaxation for short procedures such as rigid bronchoscopy. A more modern alternative is the application aof rocuronium, reversed by sugammadex. The investigators compare the intubating conditions, incidence of postoperative myalgia (POM) as well as patient satisfaction for these two muscle relaxants.

Official Title
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Comparing Intubating Conditions Using Succinylcholine or Rocuronium/Sugammadex for Rigid Bronchoscopy: a Randomized Study

Conditions
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Intubating Conditions, Postoperative Myalgia, Patient Satisfaction

Intervention / Treatment
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* Drug: Succinylcholine
* Drug: Rocuronium 0,3
* Drug: Rocuronium 0,6


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age > 18 yr scheduled for elective rigid bronchoscopy Exclusion Criteria: known neuromuscular disease significant hepatic or renal dysfunction family history of malignant hyperthermia known allergy to one of the drugs used in this protocol pregnancy or breastfeeding

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Succinylcholine<br>Succinylcholine 0,5mg/kg as muscle relaxant during induction of anaesthesia for rigid bronchoscopy | Drug: Succinylcholine<br>* Anaesthesia is induced and maintained with propofol (1-2 mg/kg) and remifentanil (0,5 µg/kg). The study arm is immobilized and after cleaning the skin a dual electrode for peripheral nerve stimulation is placed over the ulnar nerve near the wrist. Neuromuscular monitoring is performed with accelerometry. After induction of anaesthesia the patient receives muscle relaxant according to the study group.<br>|
| Active Comparator: Rocuronium 0,3<br>Rocuronium 0,3 mg/kg during induction of anaesthesia for rigid bronchoscopy. At the end of procedure 2mg/kg sugammadex for reversal of neuromuscular block are applied. | Drug: Rocuronium 0,3<br>* General anaesthesia is induced and maintained with propofol (1-2mg/kg) and remifentanil (0,5µg/kg). The study arm is immobilized and after cleaning the skin a dual electrode for peripheral nerve stimulation is placed over the ulnar nerve near the wrist. Neuromuscular monitoring is performed with accelerometry. The Patient receives the muscle relaxant according to the study group.<br>|
| Active Comparator: Rocuronium 0,6<br>Rocuronium 0,6 mg/kg during induction of anaesthesia for rigid bronchoscopy. At the end of procedure 2mg/kg sugammadex for reversal of neuromuscular block are applied. | Drug: Rocuronium 0,6<br>* General anaesthesia is induced and maintained with propofol (1-2mg/kg) and remifentanil (0,5µg/kg). The study arm is immobilized and after cleaning the skin a dual electrode for peripheral nerve stimulation is placed over the ulnar nerve near the wrist. Neuromuscular monitoring is performed with accelerometry. The Patient receives the muscle relaxant according to the study group.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Intubating Condition | The intubating conditions will be measured using the scoring system proposed for Good Clinical Research Practice using the following variables: conditions of inserting the rigid bronchoscope, vocal cord position and coughing | after induction of general anaesthesia (after 3-5 minutes) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative Myalgia | The severity of POM is measured by using a four-point-scale: 0. no myalgia minor pain limited to one area of the body muscle pain or stiffness noticed spontaneously by the patient, which may have required analgesic therapy generalized, severe or incapacitating discomfort | 72 hours after intervention | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Succinylcholine, Rocuronium, Rigid Bronchoscopy