Blood Collection From Individuals With Lung Disease for Genetic Studies

Study Overview
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Brief Summary
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This is a research study where researchers are collecting blood to evaluate the genetic characteristics of individuals with chronic lung diseases, including asthma, chronic obstructive pulmonary disease (COPD), interstitial lung disease, cystic fibrosis, and lung cancer.

Detailed Description
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The investigators hope to be able to identify an association between a genetic make-up in the blood samples and the risks of developing a particular lung disease, or severity of a lung disease. The findings of this study might be important to develop future preventative methods and potential treatments for the management of lung disease. The investigators aim to collect blood samples from 300 people with lung disease and 300 controls over 5 years.

Official Title
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Collection of Blood for Gene Expression/Genomic Studies in Individuals With Chronic Lung Disease

Conditions
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Asthma, COPD, Interstitial Lung Disease, Cystic Fibrosis, Lung Cancer

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Must provide informed consent Males and females, age 18 years and older Lung disease proven by at least one of the following: symptoms consistent with pulmonary disease chest X-rays consistent with lung disease pulmonary function tests consistent with lung disease lung biopsy consistent with lung disease family history of lung disease disease of organs with know associated with lung disease individuals suspected of history of lung disease based on history and/or physical examination normal controls (individuals without history of lung disease) to be sampled to provide a comparison to the lung disease cohort. Exclusion Criteria: Drug and/or alcohol abuse within the past six months Females who are pregnant or nursing

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1: Lung Disease<br>Individuals with at least one of the following: (1)symptoms consistent with pulmonary disease; (2) chest X-ray consistent with lung disease; (3) pulmonary function tests consistent with lung disease; (4) lung biopsy consistent with lung disease; (5) family history of lung disease; (6) patients with diseases of organs with known association with lung disease; (7) individuals suspected of history of lung diseased based on history and/or physical examination | |
| 2: Normal Controls<br>Individuals without a history of lung disease | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Establish a set of normal ranges for various parameters in healthy individual specimens and compare to specimens from individuals with lung disease to determine parameters resulting in disease susceptibility and severity. |  | 5 years |