Primary Failure of Eruption (PFE) : Highlighting of Clinical, Radiological and Genetic Diagnostic Criteria: Consequences on the Therapeutic Management

Study Overview
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Brief Summary
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The primary purpose of the study is to identify clinical, radiological and genetic diagnostic criteria for Primary Failure of Eruption (PFE). The secondary purposes are to highlight the genotype-phenotype correlations in the PTHR1 and non-PTHR1 forms and analyze the therapeutic failures.

Official Title
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Primary Failure of Eruption (PFE) : Highlighting of Clinical, Radiological and Genetic Diagnostic Criteria: Consequences on the Therapeutic Management

Conditions
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Primary Failure of Eruption

Intervention / Treatment
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* Genetic: genetic analysis
* Radiation: panoramic radiography
* Radiation: teleradiography
* Radiation: intraoral X-rays
* Radiation: CT scan of maxillary and mandible


Participation Criteria
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Eligibility Criteria
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Inclusion criteria: people over 6 years old people with Primary Failure Eruption Exclusion criteria: children under 6 years old endocrine pathology that may interfere with dental eruption rickets chemotherapy / radiotherapy bisphosphonate treatment

Ages Eligible for Study
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Minimum Age: 6 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Interventional Model Description: single group
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Genetic: genetic analysis|saliva is collected for DNA extraction|
|Radiation: panoramic radiography|panoramic radiography|
|Radiation: teleradiography|teleradiography|
|Radiation: intraoral X-rays|intraoral X-rays|
|Radiation: CT scan of maxillary and mandible|CT scan of maxillary and mandible|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of teeth | number of teeth | at inclusion (day 1) | 
| Recording of dental caries | recording of dental caries by Decayed Missing Filled Teeth index (DMFT index) | at inclusion (day 1) | 
| Recording the location of dental caries | the number of teeth affected using the international classification index | at inclusion (day 1) | 
| Drugs intra uterine exposure | drugs during pregnancy | at inclusion (day 1) | 
| Nutritional deficiencies | nutritional deficiencies assessed by a questionnaire | at inclusion (day 1) | 
| Periodontium | assessment of the periodontium by Maynard and Wilson classification | at inclusion (day 1) | 
| Oral hygiene | assesment of oral hygiene by plaque index (Löe and Silness, 1963) | at inclusion (day 1) | 
| Gingival inflammation | assesment of gingival inflammation by gingival index (Löe and Silness, 1963) | at inclusion (day 1) | 
| Treatment needs | assessment of treatment needs using Community Periodontal Index of treatment Needs (CPITN) | at inclusion (day 1) | 
| Face shape | assesment of the face shape : round, square, oval | at inclusion (day 1) | 
| Symmetry of the face | symmetry of the face (yes/no) | at inclusion (day 1) | 
| Profile (shape) | assessment of the profile (shape) | at inclusion (day 1) | 
| Smile | morphology of the smile | at inclusion (day 1) | 
| Vertical dimension | assessment of the vertical dimension: anterior infraclusion or overbite (in %) | at inclusion (day 1) | 
| Transversal dimension | assessment of the transversal dimension: posterior transversal dimension (in mm) | at inclusion (day 1) | 
| Sagittal dimension | Assessment of the sagittal dimension by Angle's classification | at inclusion (day 1) | 
| Chewing | Assessment of chewing by Plana's Functional Masticatory Angles (PFMA) | at inclusion (day 1) | 
| Nasal breathing | Assessment of nasal breathing by the Rosenthal's test | at inclusion (day 1) | 
| Swallowing | Assessment of swallowing by lingual interposition | at inclusion (day 1) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mutations causing PFE |  | at inclusion (day 1) | 
| Type of treatment performed | (orthodontics, surgery, prothesis) | at inclusion (day 1) |