Evaluation of a Cognitive Remediation Program for Mood Disorders

Study Overview
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Brief Summary
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Psychotherapeutic management of cognitive disorders in patients suffering from a mood disorder

Official Title
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Evaluation of a Cognitive Remediation Program for Mood Disorders

Conditions
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Taking Charge of Cognitive Impairment in Patients With Mood Disorders

Intervention / Treatment
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* Behavioral: Evaluation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age between 18 and 65 years old The patient's previous diagnosis of Bipolar-Related Disorder or Depressive Disorder according to the DSM-5 criteria. Mood stabilized with respect to depressive symptomatology (absence or presence of residual mild depressive symptoms (HDRS-17 ≤ 18)) Mood stabilized with respect to manic symptomatology (absence or presence of residual mild manic symptoms (YMRS ≤ 8)) Stable and effective treatment at minimum dose for at least 2 months Cognitive complaint expressed by the patient, and detected by the patient's referring psychiatrist Free and Informed Consent Form read, initialled and signed Patient affiliated to a social protection scheme or beneficiary of State Medical Aid Patient knowing how to speak French - Exclusion Criteria: Presence of a DSM-5 disorder, other than a mood, anxiety or personality disorder Substance addiction or abuse (Alcohol, psychoactive substances) in the past 12 months Manic, hypomanic or major depressive episode in the last 2 months Somatic or neurological disorder which may lead to cognitive impairment Current or less than one month's commitment to another research protocol A neuropsychological assessment prior to 6 months. Patient under protective custody, guardianship or reinforced guardianship

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Evaluation of the specific therapeutic efficacy of Cognitive Training Therapy for Bipolar Patients on cognitive deficits in patients with bipolar disorder, treated over three months and followed up over nine months. Randomized, double-blind study.
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Eco Program (Ecological Cognitive Training for Mood Disorders)<br>Duration: four months, 16 sessions Frequency: One one-hour session and one hour of personal work per week Modalities: Paper and pencil exercises and manipulable tools Objective: Learning problem-solving strategies for use in daily life Modules: Psychoeducation, Information Processing, Memory, Concept Formation, Functional Disorders | Behavioral: Evaluation<br>* Evaluation of a cognitive remediation program for mood disorders<br>|
| Active Comparator: ThOR Program (Remission Oriented Therapy)<br>Duration: four months, 16 sessions Frequency: One one-hour session and one hour of personal work per week Modalities: Paper tools and verbal exchange with the patient Objective: Improvement of the patient's quality of life Themes: Mood, social skills, autonomy, motivation, sleep | Behavioral: Evaluation<br>* Evaluation of a cognitive remediation program for mood disorders<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the Perceptual Reasoning Index (PRI) the Wechsler Intelligence Scale. | Increase in the Perceptual Reasoning Index (PRI) of the Wechsler Adult Intelligence Scale - Fourth Edition [WAIS-IV] significantly different between the two study groups. | at 1 year |