Assessment of Cognitive Functioning as it Relates to Risk for Suicide in Veterans With HIV/AIDS

Study Overview
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Brief Summary
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The purpose of this project is to gather pilot data related to exploring relationships between cognitive impairment and/or psychiatric distress and suicidal thoughts and/or behaviors in Veterans with Human Immunodeficiency Virus (HIV)/Acquired Immune Deficiency Syndrome (AIDS). To achieve this goal, a neuropsychological battery will be administered to Veterans with HIV/AIDS.

Official Title
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Assessment of Cognitive Functioning as it Relates to Risk for Suicide in Veterans With HIV/AIDS

Conditions
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HIV/AIDS

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Veterans between ages 18 to 65 Have a diagnosis of HIV/AIDS confirmed via medical record Currently receiving or eligible to receive physical and/or mental health care through the VA Eastern Colorado Health Care System Exclusion Criteria: Acute intoxication via alcohol or other illicit drugs at time of assessment as determined by observation and/or interview. Psychosis at time of interview as determined by observation and/or interview. Poor Test of Memory Malingering (TOMM) performance (scores below 25 on Trial 1 or scores lower than 45 on Trial 2) Current status as a prisoner

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Veterans with HIV/AIDS<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV) | The WAIS-IV is a widely used and well established instrument used to assesses an individual's intellectual functioning within various cognitive domains and organizes performance into several indices including Verbal Comprehension Index, Perceptual Reasoning Index, Working Memory Index, and Processing Speed Index. A composite, Full Scale IQ, is also generated to represent an estimation of overall intellectual functioning. | 1 Time Administration | 
| Trail Making Test (TMT): Parts A & B | The TMT is a timed, pencil-paper, measure of attention, speed, and cognitive flexibility and requires participants to draw a line to accurately sequence 25 circles containing numbers (Part A) and alternating letters and numbers (Part B). | 1 Time Administration | 
| California Verbal Learning Test, Second Edition (CVLT-II) | The CVLT-II examines several aspects of verbal learning, organization, and memory. | 1 Time Adminstration | 
| Delis-Kaplan Executive Function System (D-KEFS) | Measure of executive functioning. | 1 Time Administration | 
| Brief VisuoSpatial Memory Test-Revised (BVMT-R) | The BVMT-R measures immediate and delayed visual memory. | 1 Time Administration | 
| Wisconsin Card Sorting Test (WCST) | Measure of executive functioning. | 1 Time Administration | 
| Outcome Questionnaire (OQ-45) | The OQ-45 is a 45-item questionnaire that was designed to measure key areas of mental health functioning (symptom distress, interpersonal functioning, and social role). | 1 Time Administration | 
| Beck Scale for Suicide Ideation (BSS) | The BSS is a 19-item scale that assesses severity of suicide ideation. | 1 Time Administration | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Health Status Questionnaire (HSQ) | The HSQ is a 39-item, multiple choice, self-report measure that collects patient-reported, subjective data on eight subscales: Health Perception, Physical Functioning, Role Limitations/Physical Health, Role Limitations/Emotional Problems, Social Functioning, Mental Health, Bodily Pain and Energy/Fatigue. | 1 Time Administration | 
| University of Washington Risk Assessment Protocol-Revised (UWRAP) | The UWRAP will be used to address potential risk associated with participating in the study. | 1 Time Administration | 
| Test of Memory Malingering (TOMM) | The TOMM is a measure of effortful performance on objective tasks. | 1 Time Administration | 
| The Structured Clinical Interview for DSM-IV-Research Version (SCID-I) | The SCID is a reliable and valid semi-structured interview used to make psychiatric diagnosis in both clinical and research settings. | 1 Time Administration | 
| Lifetime Suicide Attempt Self Injury Interview (L-SASI) | The L-SASI was developed as a very brief survey of lifetime intentional self-harm behaviors and categorizes them into suicide attempts and non-suicidal acts. | 1 Time Administration | 
| Participant Demographics Form | A questionnaire was created by members of the research team to collect data regarding demographics. | 1 Time Administration | 
| Ohio State University TBI-ID (OSU TBI-ID) Short Form | The OSU TBI-ID Short Form will be used to determine history of TBI and presence of persistent TBI-related complaints. | 1 Time Administration | 
| Beck Hopelessness Scale (BHS) | The BHS is a 20-item true-false self-report scale that measures the level of negative expectations about the future held by respondents. | 1 Time Administration | 
| The Beck Depression Inventory (BDI-II) | The BDI-II is a widely used 21 item, self-administered instrument used to detect depression. | 1 Time Administration | 
| The Beck Anxiety Inventory (BAI) | The BAI is a widely-used, 21-item, self-administered instrument used to measure the severity of an individual's anxiety. | 1 Time Administration | 
| Military Suicide Research Consortium (MSRC) Common Data Elements | The Common Data Elements are a compilation of validated and reliable measures used to gather data on the risk factors for suicidal behavioral. | 1 Time Administration | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Veterans, HIV, AIDS, Cognitive Functioning, Suicide