Frailty in Vascular Patients Undergoing Surgery

Study Overview
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Brief Summary
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An observational cohort study of the frailty of vascular surgery patients undergoing intervention and their outcomes.

Detailed Description
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Vascular surgical operations are major procedures with significant associated morbidity and mortality. Frailty is a major factor influencing surgical outcome, but the effect on morbidity/mortality and quality of life is poorly understood in vascular surgery. Activity levels play a significant role in frailty and in pre-intervention preparation. It is anticipated that as frailty levels increase, activity levels decrease. It is hypothesised that vascular surgery patients suffer from a high prevalence of frailty and that increasing frailty will lead to increased morbidity and mortality and decreased quality of life. This initial study will provide the foundations to identify targets for improvement in degree of frailty, appropriateness for surgery and outcome. This project aims to: Assess and quantify the prevalence of frailty as well as recording activity levels in the vascular surgery patient cohort Explore the impact of frailty and pre-op activity on surgical outcomes in the vascular surgical patient cohort to guide surgical treatments as well as future studies aimed at improving frailty and activity and thereby quality of life. Identification of an appropriate metric of frailty for this population group to include activity, is a secondary aim of this proposal.

Official Title
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Vascular Frailty - An Observational Cohort Study

Conditions
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Vascular Diseases, Carotid Artery Diseases, Aneurysmal Disease, Peripheral Artery Disease

Intervention / Treatment
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* Other: Questionnaire


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All patients attending for aortic aneurysm repair, carotid artery surgery and lower limb revascularisation under the care of the Vascular Surgery team Willing and able to give informed written consent Exclusion Criteria: Those unable to give informed written consent Those <18 years of age In the opinion of the investigator unable or unwilling to comply with the requirements of the study

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Carotid Artery Disease<br>Patients with Carotid Artery Disease. Quality of life and frailty questionnaires | Other: Questionnaire<br>* Quality of life and frailty questionnaires<br>|
| Aneurysmal Disease<br>Patients with Aneurysmal Disease. Quality of life and frailty questionnaires | Other: Questionnaire<br>* Quality of life and frailty questionnaires<br>|
| Peripheral Artery Disease<br>Patients with Peripheral Artery Disease. Quality of life and frailty questionnaires | Other: Questionnaire<br>* Quality of life and frailty questionnaires<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between electronic Frailty Index and survival and complication rate. | Survival and rate of complication correlated with the pre-operative frailty score (electronic Frailty Index). | 6 months | 
| Correlation between Q Mortality Index and survival and complication rate. | Survival and rate of complication correlated with the pre-operative frailty score (Q Mortality Index). | 6 months | 
| Correlation between ACS Risk Calculator Score and survival and complication rate. | Survival and rate of complication correlated with the pre-operative frailty score (ACS Risk Calculator). | 6 months | 
| Correlation between V-Possum and survival and complication rate. | Survival and rate of complication correlated with the pre-operative frailty score (V-Possum). | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Activity Levels Pre and Post Surgery as measured by the General Practice Physical Activity Questionnaire | General Practice Physical Activity Questionnaire will be used to assess patient reported activity before and after surgery. | 6 months | 
| Quality of Life Pre and Post Surgery as measure by the EuroQoL EQ-5D questionnaire | EuroQol EQ-5D Quality of Life questionnaire will be used to assess patient reported quality of life before and after surgery. | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Vascular Diseases, Peripheral Artery Disease