Analysis of the Sweat Response According to the Pathology in Neurologic Patients

Study Overview
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Brief Summary
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Cardiovascular autonomic neuropathy (CAN) has been shown to be an important risk factor for cardiac diseases, particularly in diabetes. CAN may be investigated by a battery of laboratory cardiovascular autonomic reflex tests(initially described by Ewing). First screening for CAN (as proposed in diabetic patients) can be performed by assessing heart rate (HR) response to deep breathing, blood pressure (BP) and HR response to a 5 minutes stand test

Detailed Description
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Sweat glands are innervated by thin and un myelinated sympathetic C-fibers that can be impaired in neuropathies,especially length-dependent ones. Sweating dysfunction has been shown in several neurological peripheral disorders and it has been suggested that sweating function should be included among the diagnostic tests for the early detection of autonomic neuropathies. Several methods have been developed, but the lack of easy and quick tests to diagnose sweating dysfunction has restricted widespread use in clinical practice. Measurement of electrochemical skin conductance (ESC) using Sudoscan® is a new method for quick, non-invasive and quantitative assessment of sweating. This technique has demonstrated its usefulness in detecting autonomic and small fiber neuropathy, especially in diabetic patients.The aim of this study was to evaluate the performance of the laboratory battery of CV tests and of sweating dysfunction by Sudoscan®, alone or in combination, to differentiate MSA-P from PD. Among the CV tests, the present study particularly looked at those tests already recommended as screening bedside tests in diabetic patients (HR variations with deep breathing and BP variations during stand test) ; these tests are rapid and easy to perform. HR variations with deep breathing depend on parasympathetic tone and BP variations depend on vasomotor sympathetic response.

Official Title
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Analysis of the Sweat Response According to the Pathology in Neurologic

Conditions
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Neurological Disorder

Intervention / Treatment
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* Procedure: sweating function
* Procedure: Cardiovascular function


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with MSA-P or PD Exclusion Criteria: -

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| MSA-P<br>Patients with multiple systeme atrophy (MSA) with predominant parkinsonism (MSA-P) had evaluation of cardiovascular function and sweating function | Procedure: sweating function<br>* Sweating dysfunction by Sudoscan<br>* Other names: sweating dysfunction by Sudoscan;Procedure: Cardiovascular function<br>* Cardiovascular (CV) tests<br>|
| PD patients<br>Parkinson's disease (PD) patients had evaluation of cardiovascular function and sweating function | Procedure: sweating function<br>* Sweating dysfunction by Sudoscan<br>* Other names: sweating dysfunction by Sudoscan;Procedure: Cardiovascular function<br>* Cardiovascular (CV) tests<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sweating autonomic test | Evaluate the performance of the laboratory battery of CV tests and of sweating dysfunction to differentiate MSA-P from PD | baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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sweat gland