Phenotyping Heterogeneity and Regionality of the Aorta

Study Overview
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Brief Summary
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The aorta distributes cardiac stroke volume into the whole body through its finetuned conductance function, that is propagation and modulation of flow pattern. Physicomechanic properties of the aortic wall assure continuous and homogenous blood flow distribution to organs. The physicomechanic properties of the aortic wall are heterotopic: The collagen/elastin ratio doubles in the abdominal aorta as compared to the thoracic aorta. Malfunction of aortic conduction due to large artery stiffening (LAS) leads to premature wave reflection and excess pulsatility which translate into organ damage in low-resistance beds. The regional heterogeneity of aortic physicomechanic properties and their histomorphological substrate leading to altered regional hemodynamics are not well investigated. Within the PHaRAo population, there is a spectrum of higher and lower risk patients. The aim of this cohort study is to collect prospectively and systematically clinical research data from PHaRAo patients. This cohort study is an open-end observational study to identify master switches in aortic disease

Official Title
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Phenotyping Heterogeneity and Regionality of the Aorta

Conditions
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Large Artery Stiffness, Aortic Disease, Aortic Stenosis, Aortic Aneurysm

Intervention / Treatment
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* Other: Collection of Clinical Data


Participation Criteria
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Eligibility Criteria
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apparently healthy volunteers Inclusion Criteria: • Healthy volunteers Exclusion Criteria: < 18 years Active Medication Cardiovascular Disease MRI not possible Patients with Aortic Stenosis Inclusion Criteria: • Patients suffering from 3rd drgree Aortic Stenosis Exclusion Criteria: < 18 years MRI not possible Patients with Aortic Aneurysms Inclusion Criteria: • Patients suffering from Aortic Aneurysms Exclusion Criteria: < 18 years MRI not possible

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| healthy volunteers<br> | Other: Collection of Clinical Data<br>* prospectively and systematically collection of clinical research data from apparently healthy volunteers and patients with aortic stenosis and aneurysms<br>|
| patients with aortic stenosis<br> | Other: Collection of Clinical Data<br>* prospectively and systematically collection of clinical research data from apparently healthy volunteers and patients with aortic stenosis and aneurysms<br>|
| patients with aortic aneurysms<br> | Other: Collection of Clinical Data<br>* prospectively and systematically collection of clinical research data from apparently healthy volunteers and patients with aortic stenosis and aneurysms<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Progressive accelerated Large Artery Stiffening | measured by CMR | 5 years | 
| Development of Aortic Aneurysm | measured by CMR | 5 years | 
| Progressive accelerated Large Artery Stiffening | measured by tonometry | 5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diastolic Dysfunction | measured by CMR | 5 years | 
| Diastolic Dysfunction | measured by echocardiography | 5 years | 
| Ejection Rate and Ejection Time | measured by CMR | 5 years | 
| Ejection Rate and Ejection Time | measured by echocardiography | 5 years | 
| Flow encoded regional MRI metrics | measured by CMR | 5 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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aortic disease, large artery stiffness, aortic stenosis, aortic aneurysm