Effects of AD on VI in Patients With CF

Study Overview
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Brief Summary
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This study will investigate the effects of a chest physiotherapy manual technique (autogenic drainage) on ventilation inhomogeneity in patients with cystic fibrosis. Lung clearance index (LCI) is the primary outcome

Detailed Description
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This is a cross-over intervention assessing the effect of autogenic drainage on ventilation inhomogeneity in patients with cystic fibrosis. Electrical impedance tomography and multiple breath nitrogen washout will be performed before, immediatly after and 2h post intervention. Each participant will receive either aerosoltherapy alone or in combination with chest physiotherapy on 2 consecutive days.

Official Title
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Effects of Autogenic Drainage on Ventilation Inhomogeneity in Patients With Cystic Fibrosis

Conditions
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Cystic Fibrosis

Intervention / Treatment
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* Other: Autogenic drainage
* Drug: Aerosoltherapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Cystic fibrosis diagnosis FEV1 > 40% Able to sustain 30min of chest physiotherapy Exclusion Criteria: Presence of Burkoldheria cepacia or non tuberculous mycobacteria Orthopedic, neuromuscular or cardiac disorder likely to impact respiratory system Need for supplemental oxygen Cardiac pacemaker or internal cardiac defibrillator

Ages Eligible for Study
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Minimum Age: 6 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Interventional Model Description: Participants receive one of two interventions during the first day, and receive the alternative intervention the following day. Interventions are : aerosoltherapy + autogenic drainage or aerosoltherapy alone
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Asl + CPT<br>Aerosotherapy + Autogenic drainage | Other: Autogenic drainage<br>* Autogenic drainage is an airway clearance technique that attempts to obtain the optimal airflow to evacuate the secretions. This technique uses modulation of inspiratory and expiratory airflow at different breathing level within the vital capacity.<br>Drug: Aerosoltherapy<br>* Aerosolized drugs are individualized for each participants, in line with current standardized practice in our hospital. Those drugs will not be modified for the purpose of this study.<br>|
| Active Comparator: Asl<br>Aerosoltherapy alone | Drug: Aerosoltherapy<br>* Aerosolized drugs are individualized for each participants, in line with current standardized practice in our hospital. Those drugs will not be modified for the purpose of this study.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Lung Clearance Index | LCI will be measured before, immediately after and 2h after the experimental or control conditions as well as before and after an hospitalization. | Up to 2 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Impedance variation | Impedance change in different lung zones | Up to 1 hour | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Multiple breath washout, Electrical impedance tomography, Lung clearance index, Chest physiotherapy, Autogenic drainage, Cystic fibrosis