Spectroscopic Analysis of Tongue Tumor Samples.

Study Overview
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Brief Summary
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In squamous cell carcinoma of the tongue, complete surgical resection of the tumor generally represents the primary treatment strategy. Among factors determining the disease prognostic, the surgical margins status is essential for the continued management of the patient, with or without complementary therapies. Generally, surgical margins are defined using visual and tactile elements. Unfortunately, in 15 to 30 percent of cases, they are defined as positive after histopathological examination, on average 5 to 7 days post-surgery. Techniques have recently been developed to analyze the cancerous and non-cancerous nature of tissues, using the spectral properties of tumor cells. SpiderMass™ is an instrument equipped with a probe for tissue micro-sampling and real-time molecular profile analysis. It is thus ultimately a tool for anatomopathological decision support, for diagnosis and prognosis of the disease. Used in the operating room, SpiderMass™ could also become an innovative surgical tool to precisely define cancerous areas in situ and the margins status in intraoperative conditions. Based on the principle of artificial intelligence, the SpiderMass™ machine must initially learn to recognize pathological tissues versus healthy. This project aims to accomplish this first phase of machine learning for squamous cell carcinoma of the tongue.

Official Title
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Prospective Analysis of Tumor Tissues From the Oral Cavity by SpiderMassTM Spectroscopy

Conditions
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Mass Spectroscopy, Molecular Profile, Surgical Margins, Squamous Cell Carcinoma, Oral Cavity, Tongue

Intervention / Treatment
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* Procedure: tongue surgery


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age : 18 years and older squamous cell carcinoma of the tongue surgical resection as first-line treatment tumor classification T1 to T4. Exclusion Criteria: metastatic disease neoadjuvant therapies

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| tumor samples<br>(SCC of the tongue) | Procedure: tongue surgery<br>* In squamous cell carcinoma of the tongue, complete surgical resection of the tumor<br>|
| healthy tissues<br> | Procedure: tongue surgery<br>* In squamous cell carcinoma of the tongue, complete surgical resection of the tumor<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Tumor cells detection in tongue tumor with SpiderMass technique | Tumor cells detection in tongue tumor with SpiderMass technique | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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mass spectroscopy, molecular profile, surgical margins, squamous cell carcinoma, oral cavity, tongue