The Visual Plasticity During Adversity and Prosperity in Infants With Congenital Cataracts

Study Overview
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Brief Summary
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Phenotypic plasticity is the ability of individuals to change their phenotypic status when exposed to environmental variations. However, whether the plastic changes show differential susceptibility in adversity and prosperity is debated and the specific pattern of plasticity remains elusive. Here the investigators address this question by tracking the phenotypes (functional, structural, physical, and attachment traits) in two groups of infants before and after visual deprivation: one group experienced a short duration of complete deprivation (extreme adversity) and the other group experienced a long durations of partial deprivation (watered-down adversity).

Official Title
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The Susceptibility of Phenotypic Plasticity During Adversity and Prosperity in Infants With Visual Deprivation

Conditions
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Cataract

Intervention / Treatment
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* Procedure: bilateral cataract removal surgery for dense cataract
* Procedure: bilateral cataract removal surgery for non-dense nuclear cataract


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosis with dense or non-dense nuclear congenital cataract Exclusion Criteria: no metabolic diseases, mental retardation or central nervous diseases had no history of inherited diseases
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: dense cataract group<br> | Procedure: bilateral cataract removal surgery for dense cataract<br>* Participants were born with dense bilateral cataracts (extreme adversity) will undergo surgery for bilateral cataract removal at an early age, mostly around 3 months of age.<br>|
| Experimental: non-dense nuclear cataract group<br> | Procedure: bilateral cataract removal surgery for non-dense nuclear cataract<br>* Participants were born with non-dense and nuclear bilateral cataracts (watered-down adversity) will undergo cataract removal surgery bilaterally in a compromised timing, mostly around one year old.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from baseline in visual acuity measured by Teller visual acuity cards |  | 1 day, 1 week, 2 weeks, 1 month, 3 months, 6 months and 12 months after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from baseline in refractive status measured by autorefractor and objective retinoscopy |  | 1 day, 1 week, 2 weeks, 1 month, 3 months, 6 months and 12 months after surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Phenotypic plasticity, Adversity, Prosperity