Comparison of Multifocal Electroretinogram Assessment in Chronic Central Serous Chorioretinopathy (CSC) Between Laser Treatment Group and Photodynamic Therapy Group in Chronic Central Serous Chorioretinopathy

Study Overview
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Brief Summary
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This study is a comparison of multifocal electroretinogram assessment between the laser treatment group and the photodynamic therapy group in chronic central serous chorioretinopathy.

Detailed Description
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Laser Group: extrafoveal focal leakage on FAG PDT Group: no definite focal leak on FAG subfoveal or juxtafoveal focal leakage on FAG, or serous retinal pigmentary epithelial detachment involving foveal center Inclusion criteria Chronic serous chorioretinopathy (over 3 months) when subretinal fluid persisted in the subfoveal region demonstrated by clinical examination and OCT Ability to maintain steady fixation for mfERG Presence of abnormal dilated choroidal vasculature in ICGA Symptom duration over 3 months Exclusion criteria previous PDT or laser treatment history evidence of Choriinal neovascularization in FAG other chorioretinal disorders that can cause macular exudation such as age-related macular degeneration, pathologic myopia, angioid streaks, trauma, inflammatory diseases, retinal vasculopathies, and hereditary dystrophies follow-up Visit 1)baseline 2)1month 3)3months 4)6 months each visit: multifocal electroretinogram, visual acuity, optical coference timography should be measured.

Official Title
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Comparison of Multifocal Electroretinogram Assessment Between Laser Treatment Group and Photodynamic Therapy Group in Chronic Central Serous Chorioretinopathy

Conditions
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Central Serous Chorioretinopathy

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: CSC (over 3 months) when subretinal fluid persisted in the subfoveal region demonstrated by clinical examination and OCT Ability to maintain steady fixation for mfERG Presence of abnormal dilated choroidal vasculature in ICGA Symptom duration over 3 months Exclusion Criteria: Previous PDT or laser treatment history Evidence of CNV in FAG Other chorioretinal disorders that can cause macular exudation such as age-related macular degeneration, pathologic myopia, angioid streaks, trauma, inflammatory diseases, retinal vasculopathies, and hereditary dystrophies

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Photodynamic therapy (PDT)<br> | |
| Focal laser photocoagulation (focal)<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Multifocal Electroretinogram Amplitudes | Amplitude at first annular ring at multifocal electroretinogram RETIscan (Roland Consult, Wiesbaden, Germany) is used for multifocal retinogram. The recording protocol was chosen according to the International Society for Clinical Electro-physiology of Vision (ISCEV) guidelines. | baseline, 1 month, 3 months, 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Best Corrected Visual Acuity | Best-corrected visual acuities were obtained with Snellen charts. Snellen's visual acuity was converted logarithm of the minimum angle of resolution (logMAR) for statistical analysis. | baseline, 1 month, 3 months, 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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chronic central serous chorioretinopathy, multifocal electroretinogram, central retinal function after treatment in chronic serous chorioretinopathy