Prognosis of Anxiety in Intensive Care Unit

Study Overview
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Brief Summary
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Anxiety is commonly considered as an epiphenomenon of the cognitive and emotional response to a threat. Anxiety is a consequence of the reciprocal interaction between stress and the neuroendocrine, autonomic and immune systems. A systematic and circumstantial assessment of anxiety in critically ill patients has never been done. Our hypothesis is that high levels of anxiety at ICU admission are associated with death or the occurrence of one or more organ failure during the first 7 days, and that anxiety should be considered as a warning sign in critically ill patients.

Detailed Description
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Multicentre prospective study. Demographic data, diagnosis, severity scores and vital signs will be assessed at admission. Within the first 12 hours, and at day 4 and day 7, anxiety will be assessed by the STAI scale, Geriatric Anxiety Inventory (GAI) scale, and a specific questionnaire assessing anxiety in the intensive care (REAX). Visual Analogue Scale (VAS) scoring for anxiety, starvation, thirst, pain and dyspnoea will be collected daily. Anxiety and depression will be evaluated by the Hospital Anxiety and Depression Scale (HADS) on day 7. Patients will be assessed by psychologists or trained doctors, the team in charge of the patient will not be aware of the result of this evaluation. Clinical and biological data regarding the hemodynamic, neurological, respiratory and renal status will be collected from admission to day 7, as well as parameters required for computing the Sequential Organ Failure Assessment (SOFA) score.

Official Title
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Prognosis of Anxiety in Intensive Care Unit

Conditions
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Anxiety

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All adult patients admitted to the ICU Patient without delirium at admission (assessed using the CAM-ICU score) Exclusion Criteria: Severe hearing impairment or poor understanding of French language History of serious psychiatric illness Comatose or sedated patient at admission Diagnosis of voluntary self-poisoning, or polytrauma at admission

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Occurrence of death or organ failure. |  | 7 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 1-Occurrence of shock, delirium, or stress-related complications (upper gastrointestinal bleeding, acute coronary syndrome) |  | 7 days | 
| Severity of an ongoing organ failure (maximum SOFA score) |  | 7 days | 
| Assessment of anxiety according to State Trait Anxiety Inventory score (STAI) |  | 7 days | 
| Assessment of anxiety according to REAX score |  | 7 days | 
| Assessment of anxiety according to the Visual Analog Scale (VAS) |  | 7 days | 
| Assessment of Geriatric Anxiety Inventory score (GAI) |  | 7 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Anxiety, level of anxiety, delirium, agitation, tools for measuring anxiety, neuroendocrine system