Computed Tomography (CT) and Lung Function Data Collection for Computational Fluid Dynamics (CFD) in Chronic Obstructive Pulmonary Disease (COPD) Patients

Study Overview
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Brief Summary
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In this study, 20 COPD patients will undergo a high-resolution/multi slice CT scan and lung function tests to obtain patient specific geometries of the central and peripheral small airways and patient specific boundary conditions. With Computational Fluid Dynamics (CFD), the investigators will be able to reconstruct the geometry and measure the resistance of the peripheral airways. In a later stage, CFD will be used to simulate the reaction of the airways on various inhalation medications.

Official Title
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Computed Tomography (CT) and Lung Function Data Collection for Computational Fluid Dynamics (CFD) in COPD Patients

Conditions
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Chronic Obstructive Pulmonary Disease

Intervention / Treatment
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* Procedure: Computed Tomography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with documented COPD based on the following criteria: Smoking history of at least 10 pack-years. Decreased Tiffeneau index (FEV1/(F)VC < 0.70). Patients aged ≥ 40 years. Patients should present moderate to very severe COPD with an FEV1 < 80% of predicted (GOLD 2, 3 and 4). Patients should be treated according to GOLD guidelines. Maintained on stable respiratory medications for 4 weeks prior to visit 1 Able to perform lung function tests. Exclusion Criteria: Patients below the age of 40. Patients who are pregnant or are breast-feeding. A respiratory infection or exacerbation of COPD in the four weeks prior to screening. BMI > 35 kg/m². Patients treated with BiPAP or CPAP. Known active tuberculosis. A history of asthma, cystic fibrosis, central bronchiectasis, interstitial lung disease or pulmonary thromboembolic disease. A history of thoracotomy with pulmonary resection. Active or untreated malignancy.

Ages Eligible for Study
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Minimum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: 1<br> | Procedure: Computed Tomography<br>* 1 low-dose CT is taken<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To obtain patient specific geometries of the central and peripheral small airways |  |  | 
| To obtain patient specific boundary conditions |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To measure the resistance of the peripheral airways |  |  | 
| To measure the reaction of the airways on various inhalation medications |  |  | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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COPD