linjc16/ctgov huggingface dataset:
Measurement of Circulating Cell-free DNA (cfDNA) for Diagnosis and Prognosis of Various Diseases and Evaluation of Tissue Damage

Study Overview
=================
Brief Summary
-----------------
To characterize the changes in circulating cell-free DNA (cfDNA) levels during cardiopulmonary bypass (CPB) and to access their association with outcomes compared to standard scores.

Detailed Description
-----------------
In a prospective study, the investigators enrolled seventy-one consecutive patients undergoing non-emergent coronary artery bypass grafting. Blood was drawn at baseline, after 20 and 40 minutes on CPB, after cross-clamp removal, and 30 minutes after chest closure. cfDNA was measured in sera by fluorescent method. The investigators hypothesize that cfDNA measured by will reflect the magnitude of inflammation induced by CPB. Thus, these measurements could serve for the real-time prognosis of patients undergoing cardiac surgery. The investigators correlate cFDNA to laboratories and clinical outcomes.

Official Title
-----------------
Development of a Fast and Sensitive Method for Measurement of Circulating Cell-free DNA (cfDNA) for Diagnosis and Prognosis of Various Diseases and Evaluation of Tissue Damage Following Trauma

Conditions
-----------------
Correlation of cFDNA During CPB to Laboratories SIRS Parameters and Clinical Outcomes

Intervention / Treatment
-----------------
* Diagnostic Test: Blood samples


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Elective coronary artery bypass grafting surgery Exclusion Criteria: Age < 18 Non elective surgery other than CABG surgery Redo CABG

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: Blood samples|5 blood samples for each patient during CABG (coronary artery bypass grafting) surgery pre/on/post cardiopulmonary bypass machine|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| prolong LOS-length of stay | intensive care unit length of stay | > 18 hours after the surgery | 
| Mortality | Mortality | short term - 30day; long term > 1year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Neutrophil-NETosis | Neutrophil extracellular traps (NETs) released from activated neutrophils that undergo NETosis. | 2 hours after the surgery | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
cfDNA-Circulating cell-free DNA, CPB-cardiopulmonary bypass, SIRS-systemic inflammatory response syndrome
Deep Brain Stimulation (DBS) Frequency Effects on Gait in Parkinson's Disease(PD)

Study Overview
=================
Brief Summary
-----------------
In this study the investigators will evaluate the effect of both low and high frequency Deep Brain stimulation of the subthalamic nucleus (STN) in Parkinson's patients who have noted a change in their walking. The investigators' hypothesis is: Stimulation at 60 Hertz (Hz) is associated with improved gait with increased stride length and faster time on the Stand walk sit test. There is no worsening of the Unified Parkinson's Disease Rating Scale (UPDRS) at 60 Hz.

Official Title
-----------------
Effect of Frequency Change in Bilateral Subthalamic Nucleus (STN)-DBS on Gait Function in PD

Conditions
-----------------
Parkinson Disease

Intervention / Treatment
-----------------
* Procedure: Frequency change to 60 Hz
* Procedure: Frequency change to 130 Hz


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Be a patient at the Vanderbilt Movement Disorders clinic. Report a change in their gait. Be able to walk independently when off PD medications for 12-16 hours. Have a stable dose of PD medications for the prior three months . Not cognitively impaired, so as to give informed consent. MMSE > 24. Exclusion Criteria: See inclusion criteria.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Baseline frequency<br>Baseline DBS frequency | Procedure: Frequency change to 60 Hz<br>* 60 Hz stimulation for one hour, done twice over the 5 hour study period in a randomized blinded fashion.<br>* Other names: 60 Hertz;Procedure: Frequency change to 130 Hz<br>* 130 Hz Stimulation for one hour, done twice over the 5 hour study period in a randomized blinded fashion.<br>* Other names: 130 Hz;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Stride Length From Baseline | Evaluation performed after DBS frequency setting changed for one hour, compared to the subject's baseline DBS frequency stride length | 1 hour | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Gait Velocity | gait velocity measured as change from baseline in in CM/second | 5 hours | 
| Time to Walk 14 Meters | Change in the time to walk 14 meters compared to baseline measured in seconds | 5 hours | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Parkinson's Disease, DBS, Frequency, Deep brain stimulation
Efficacy of Acetaminophen-ibuprofen Combination on the Postoperative Pain After Laparoscopic Gynecology Surgery

Study Overview
=================
Brief Summary
-----------------
Acetaminophen and ibuprofen has been safely used for a long time and reduces postoperative pain and opioid dosages. Investigators are planning to compare the efficacy of 1) acetaminophen only and 2) acetaminophen and ibuprofen combination at postoperative pain after laparoscopic gynecologic surgery.

Detailed Description
-----------------
Acetaminophen and ibuprofen has been safely used for a long time and reduces postoperative pain and opioid dosages. Investigators are planning to compare the efficacy of 1) acetaminophen 1g only and 2) the combination of acetaminophen 1g and ibuprofen 300mg at postoperative pain after laparoscopic gynecologic surgery. Some recovery valuables such as the postoperative pain and opioid requirements will be assessed.

Official Title
-----------------
Efficacy of Acetaminophen-ibuprofen Combination on the Postoperative Pain After Laparoscopic Gynecology Surgery

Conditions
-----------------
Gynecologic Disease

Intervention / Treatment
-----------------
* Drug: Acetaminophen
* Drug: Ibuprofen


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients scheduled gynecologic laparoscopic surgery Exclusion Criteria: Refusal to be enrolled in the study Emergency surgery On chronic pain medications Psychiatric disorders Pregnant, lactating women Allergy or contraindication to the medication drugs

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: control group<br>acetaminophen 1g iv dripping | Drug: Acetaminophen<br>* acetaminophen 1g iv dripping at end of surgery<br>|
| Experimental: experimental group<br>the combination of acetaminophen 1g and ibuprofen 300mg iv dripping | Drug: Acetaminophen<br>* acetaminophen 1g iv dripping at end of surgery<br>Drug: Ibuprofen<br>* ibuprofen 300mg iv dripping at end of surgery<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| postoperative pain | the maximal postoperative pain severity using pain scale (0=no pain; 10=the worst pain) | during 30 minutes after surgery |
Bortezomib and Low Dose Cytarabine in the Treatment of High-Risk Myelodysplastic Syndromes

Study Overview
=================
Brief Summary
-----------------
We are evaluating the efficacy of the association of Low dose Cytarabine in association with Bortezomib in the treatment of patients diagnosed with high risk Myelodysplastic syndromes. Our aim is to decrease transfusion requirements and if possible induce a complete or at least a partial remission.

Detailed Description
-----------------
Four cycles of treatment are proposed at 28 day intervals in an ambulatory setting Cycle 1 : Cytarabine 10 mg /m2/day subcutaneous injection for 14 days Bortézomib 1,5mg/m2 days 1,4,8,11 Cycles 2, 3, 4 : Cytarabine 20 mg /m2/j subcutaneous injections for 14 days Bortézomib 1,5mg/m2 days 1,4,8,11 Bone marrow aspirates are evaluated just before the first cycle, after the second and after the fourth cycles Responding patients may continue the treatment for 2 further cycles

Official Title
-----------------
Phase I/II Study of Bortezomib and Low Dose Cytarabine in the Treatment of High-Risk Myelodysplastic Syndromes

Conditions
-----------------
Myelodysplastic Syndromes

Intervention / Treatment
-----------------
* Drug: Bortezomib


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: MDS with IPSS scores Int-2 or High Life expectancy greater than 6 months No other available treatment options Exclusion Criteria: MDS with IPSS scores Low or Int-1 > 30% bone marrow blasts clinical neuropathy of greater than grade 2 ECOG Score 3 or 4 Creatinine clearance of < 30 ml/min LMMC Pregnant patients or lactating mothers Patients having received intensive chemotherapy in the 3 months prior to inclusion Patients with uncontrolled pulmonary, cardiac, neurological, gastro-intestinal or genito-urinary disorders

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Bortezomib|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Complete Response |  |  | 
| Partial Response |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hematological Improvement |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Myelodysplastic syndromes, IPSS Int-2 and High risk, Bortezomib, Low dose Cytarabine, Bone Marrow diseases
Long-Term Follow-up Study of Patients Who Received PB127 Ultrasound Imaging Agent

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to collect longer term follow-up information concerning health and survival on selected patients who received PB127 for injectable suspension in the pivotal trial (127-014).

Official Title
-----------------
Long-Term Follow-Up of Selected Patients Enrolled in Phase 3 Clinical Trial 127-014 Using PB127 Ultrasound Imaging Agent

Conditions
-----------------
Coronary Artery Disease

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients enrolled in Protocol 127-014 who Were enrolled in Stratum 1 Did not undergo angiography during study evaluation Did not have a clinical oucome during the initial 6 month follow-up period as described in Protocol 127-014.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To collect longer-term follow-up clinical information on selected patients enrolled in Protocol 127-014 |  | 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
ultrasound, perfusion, SPECT, coronary artery disease, chest pain, low probability, angiography, clinical outcomes
Reproductive Outcome of EM Treated by GnRH-a Associated With Laparoscopy

Study Overview
=================
Brief Summary
-----------------
This study is a multicenter, randomized-control-trial. This study select 1184 Infertile patients associated with endometriosis diagnosed by laparoscopy surgery. Patients are going to be divided into two groups according to 1:1 ratio randomly assigned to receive GnRH-a. Cumulative pregnancy rate, end of treatment to natural pregnancy time, accept the assisted reproductive treatment rate, miscarriage rate, live birth rate will be recorded.

Official Title
-----------------
Efficacy of Laparoscopic Surgery Combined With GnRH-a in the Treatment of Endometriosis Associated Infertility: A Multicenter, Prospective, Randomized-control-trial

Conditions
-----------------
Infertility Associated With Endometriosis

Intervention / Treatment
-----------------
* Drug: Goserelin Acetate


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Infertile patients Endometriosis I-II phase：according to Revised American Society for Reproductive Medicine classification of endometriosis: 1996 BMI:19-28 kg/㎡ Ovarian reserve function is normal（M2-5：bilateral antral follicles≥6 FSH：5-12U/ml） Exclusion Criteria: Male factor causes infertility hydrosalpinx or salpingemphraxis Uterine malformation Uterine cavity lesion Contra-indications for GnRH-a not willing to participate

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 35 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: GnRH-a<br>patients treated with GnRH-a after surgery and Outpatient guidance . | Drug: Goserelin Acetate<br> <br> |
| No Intervention: non GnRH-a<br>patients treated with outpatient guidance only. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cumulative pregnancy rate | Cumulative pregnancy rate of 18 month after surgery | 18 month after surgery | 
| Time interval between surgery and natural pregnancy | Time interval between surgery and natural pregnancy | 18 month after surgery | 
| miscarriage rate | miscarriage rate of patients who get natural pregnancy | 18 month after surgery | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
GnRH-a, endometriosis, efficiency
Acute Anterior Uveitis: Psychic Burden and Pain

Study Overview
=================
Brief Summary
-----------------
Acute anterior uveitis (AU) is a common reason for attendance at ophthalmic outpatient clinics. The painfulness and the fear of a transient or even persistent loss of vision may markedly reduce the individual's subjective well-being and pose a psychological burden. This study will test the hypothesis that during an attack of AU the patient experiences a marked reduction in psychological and physical well-being. Prospective, hospital-based epidemiologic study using a patient questionnaire with standardized psychological tests and a pain scale.

Official Title
-----------------
Acute Anterior Uveitis: Psychic Burden and Pain

Conditions
-----------------
Anterior Uveitis

Intervention / Treatment
-----------------
* Other: Filling in a patient questionnaire


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Acute attack of anterior uveitis Exclusion Criteria: Other forms of uveitis Chronic anterior uveitis Therapy started

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| AAU<br>patient with acute attack of anterior uveitis | Other: Filling in a patient questionnaire<br>* Filling in a patient questionnaire<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
A Trial of Computer-based Attention-training Systems in Children With Attention Deficit Hyperactivity Disorder (ADHD)

Study Overview
=================
Brief Summary
-----------------
This study examines the efficacy of two computer-based training systems to teach children with ADHD to attend more effectively.

Official Title
-----------------
A Randomized Trial of Computer-based Attention-training Systems With and Without Neurofeedback in Children With ADHD

Conditions
-----------------
Attention Deficit Hyperactivity Disorder

Intervention / Treatment
-----------------
* Behavioral: Computer attention training systems for children with ADHD


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: child in 6th, 7th or 8th grade a diagnosis of ADHD (any subtype) per report of the child's physician academic achievement at grade level ability to read in English sufficiently to complete assessments and intervention protocols Exclusion Criteria: coexisting diagnosis of conduct disorder, pervasive developmental disorder, or other serious mental illness (e.g., bipolar disorder, psychosis)

Ages Eligible for Study
-----------------
Minimum Age: 10 Years
Maximum Age: 15 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: EEG biofeedback intervention<br> | Behavioral: Computer attention training systems for children with ADHD<br>* Computer attention training systems for children with ADHD, one with and one without EEG-biofeedback, were delivered via approximately 20 sessions to the participants<br>|
| Active Comparator: Non EEG biofeedback computerized attention training<br> | Behavioral: Computer attention training systems for children with ADHD<br>* Computer attention training systems for children with ADHD, one with and one without EEG-biofeedback, were delivered via approximately 20 sessions to the participants<br>|
| No Intervention: waitlist control<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in ADHD symptoms as reported by caregivers and teachers were measured at enrollment pre-intervention, and then again immediately post-intervention |  | Assessments were administered at enrollment in May-June 2006, and then immediately post-intervention after the 3 month intervention. | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
EEG-biofeedback, neurofeedback, computer attention training systems, ADHD, ADD, child, children
Pulmonary Rehabilitation in COPD: Effects of Two Aerobic Exercise Intensity in Patient-centered Outcomes

Study Overview
=================
Brief Summary
-----------------
Trial design: An equivalence/non-inferiority randomized controlled trial with parallel group design studied the effect of two aerobic exercise-training intensities in COPD patient-centered outcomes. Methods: Thirty-four COPD clinically stable patients stratified from mild to very severe GOLD stages, were blinded to 60 or 80%Wmax aerobic exercise training intensity in an outpatient pulmonary rehabilitation program, between 2009-2010. Outcomes were assessed with St.George's respiratory questionnaire (primary outcome), Mahler dyspnea index, London Chest activity of daily living scale, 6-minute walk, constant load and incremental exercise tests. Patient's allocation sequence was computer-generated, with consignment in a safe deposit box.

Official Title
-----------------
Pulmonary Rehabilitation in COPD: Effects of Two Aerobic Exercise Intensity in Patient-centered Outcomes - a Randomized Controlled Trial

Conditions
-----------------
Chronic Obstructive Pulmonary Disease

Intervention / Treatment
-----------------
* Other: Aerobic exercise training intensity


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Clinically stable COPD FEV1/FVC < 70% Exercise training medical referral Exclusion Criteria: Unable to attend 3-times/week program Infectious disease Metastatic cancer Unstable heart disease Neuromusculoskeletal disorder Cognitive or psychiatric disorder

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: 60%<br>aerobic exercise training intensity of 60%Wmax | Other: Aerobic exercise training intensity<br> <br> |
| Other: 80%<br>aerobic exercise training intensity of 80%Wmax | Other: Aerobic exercise training intensity<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Health-related quality-of-life measured by the St.George's respiratory questionnaire |  | 8 weeks (20 sessions) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Symptoms control measured by the Mahler dyspnea index |  | 8 weeks (20 sessions) | 
| Exercise Tolerance | exercise tolerance assessed by the London-Chest activity of daily-living scale, 6-minute walk test, incremental exercise test and constant-load exercise test | 8 weeks (20 sessions) | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Chronic Obstructive Pulmonary Disease, COPD, Pulmonary rehabilitation, Aerobic exercise, CEDOC, FCM, UNL, NOVA MEDICAL SCHOOL