Relationship Between Gestational Diabetes and Type 2 Diabetes

Study Overview
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Brief Summary
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The overall objective of this research project is to study the impact of preventive practices on the T2D-related risk profile among women with and without prior GDM and their children exposed and unexposed to GDM.

Detailed Description
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Type 2 diabetes (T2D) is a growing public health problem owing to its prevalence as well as its high morbidity and mortality rates. The identification of high-risk populations is of great importance particularly because the onset of T2D can be prevented or delayed by lifestyle modifications. Among high-risk populations, women with previously diagnosed gestational diabetes mellitus (GDM) are at particularly high risk of developing T2D. The success in reducing the occurrence of T2D among women with previous GDM could be achieved only if appropriate preventive measures are undertaken. According to the American Diabetes Association (ADA) and the Canadian Diabetes Association (CDA), lifestyle modifications aimed at reducing body weight and increasing physical activity are recommended and women are encouraged to be breastfeeding their infants. Certain factors have been suggested as determinants of behavioral practices in women with prior GDM including cognitive and environmental factors. A better understanding of these issues is essential for developing effective preventive strategies and possibly reducing the prevalence of T2D in the population. Moreover, in utero exposure to maternal impaired glucose tolerance or diabetes may increase the risk of developing overweight or diabetes in offspring. Since March 2012 we thus test the presence of childhood metabolic alterations predictive of future T2D in GDM-exposed and unexposed offspring and investigate environmental factors during the postnatal period that are associated with prevention of metabolic alterations.

Official Title
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Key Determinants of Type 2 Diabetes Prevention Among Women With a History of Gestational Diabetes Mellitus

Conditions
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Gestational Diabetes, Type 2 Diabetes

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Women aged ≥18 years with or without a diagnosis of GDM in the past 3-12 years and their children. Exclusion Criteria: Pregnant women, women with type 1 diabetes.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Glucose tolerance assessed using a 75g-Oral Glucose Tolerance Test (OGTT) in mothers |  | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Glycaemic and lipidic profile assessed using a fasting blood sample in children |  | 1 year | 
| overweight/obesity | In mothers and children | 1 year | 
| abdominal obesity | In mothers and children | 1 year | 
| metabolic syndrome | In mothers and children | 1 year | 
| Breastfeeding | In mothers and children | 1 year | 
| Nutrition | In mothers and children | 1 year | 
| Physical activity | In mothers and children | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Gestational diabetes, Type 2 diabetes