A Clinical Study Comparing the Comfort of Three Commercially Available Contact Lenses

Study Overview
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Brief Summary
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The purpose of this study is to compare the comfort of three commercially available contact lenses.

Official Title
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A Single-Center, Cross-over, Pilot Study Evaluating Acuvue® Oasys® Lenses (Senofilcon A), 30-Day Bausch + Lomb PureVision (Balafilcon A), and Clariti® 1-Day (Somofilcon A) Lenses, for Their Impact on Ocular Discomfort Induced by Exposure to the Turbo Controlled Adverse Environment™

Conditions
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Contact Lens Complication

Intervention / Treatment
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* Device: Acuvue® Oasys® Lenses (senofilcon A)
* Device: 30-Day Bausch + Lomb PureVision (balafilcon A)
* Device: Clariti® 1-Day (Somofilcon A)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Be at least 18 years old Have provided written informed consent Have discomfort when wearing contact lenses Exclusion Criteria: Have an active ocular infection or significant slit lamp findings Participated in any other studies in the past 30 days

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Acuvue®Oasys® Lenses(senofilcon A)<br>Acuvue® Oasys® Lenses (senofilcon A) contact lenses | Device: Acuvue® Oasys® Lenses (senofilcon A)<br>* Contact lenses placed in each eye during the day for about 8 hours<br>Device: 30-Day Bausch + Lomb PureVision (balafilcon A)<br>* Contact lenses placed in each eye during the day for about 8 hours<br>Device: Clariti® 1-Day (Somofilcon A)<br>* Contact lenses placed in each eye during the day for about 8 hours<br>|
| Active Comparator: Bausch + Lomb PureVision (balafilcon A)<br>30-Day Bausch + Lomb PureVision (balafilcon A) contact lenses | Device: Acuvue® Oasys® Lenses (senofilcon A)<br>* Contact lenses placed in each eye during the day for about 8 hours<br>Device: 30-Day Bausch + Lomb PureVision (balafilcon A)<br>* Contact lenses placed in each eye during the day for about 8 hours<br>Device: Clariti® 1-Day (Somofilcon A)<br>* Contact lenses placed in each eye during the day for about 8 hours<br>|
| Active Comparator: Clariti® 1-Day (Somofilcon A)<br>Clariti® 1-Day (Somofilcon A) contact lenses | Device: Acuvue® Oasys® Lenses (senofilcon A)<br>* Contact lenses placed in each eye during the day for about 8 hours<br>Device: 30-Day Bausch + Lomb PureVision (balafilcon A)<br>* Contact lenses placed in each eye during the day for about 8 hours<br>Device: Clariti® 1-Day (Somofilcon A)<br>* Contact lenses placed in each eye during the day for about 8 hours<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Contact lens wear comfort, as assessed by subject reported symptoms in diaries. |  | 1 week |