Exercise Training and Metabolic Syndrome

Study Overview
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Brief Summary
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The present study aimed to determine the effects of 16 weeks of aerobic interval training on quality of life and a set of clinical biomarkers.

Detailed Description
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Besides the traditional metabolic syndrome risk factors (dyslipidemia, raised blood pressure, central obesity and dysglycemia) subclinical disorders related to chronic inflammation and cell damage have been reported on metabolic syndrome. Therefore, regarding the systemic feature of metabolic syndrome, we investigated an new approach of aerobic interval training on several clinical biomarkers widely used. Such training used differs from current aerobic protocols in order to attenuate metabolic and musculoskeletal overload on untrained and unhealthy subjects.

Official Title
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Effects of Aerobic Interval Training on Clinical Biomarkers and Quality of Life in Metabolic Syndrome

Conditions
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Metabolic Syndrome

Intervention / Treatment
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* Behavioral: Aerobic interval training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Having metabolic syndrome according to international diabetes foundations definition (IDF). Age between 35 - 60 years and untrained subjects. Exclusion Criteria: Musculotendinous or osteoarticular injuries in the lower limbs and/or spine Chronic pulmonary diseases Neurological disorders Kidney failure High-risk cardiovascular diseases (Unstable angina pectoris, Uncompensated heart failure, complex ventricular arrhythmias or myocardial infarction during the last month).

Ages Eligible for Study
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Minimum Age: 35 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: intervention<br>Aerobic interval training | Behavioral: Aerobic interval training<br>* Carried out 3 times per week for 16 weeks<br>|
| No Intervention: Control group<br>The participants performed only initial evaluation and at the end of the study | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pro-inflammatory marker | Serum levels of C-reactive protein | 16 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quality of life | The Medical Outcomes Study-Short Form 36 (SF-36) | 16 weeks | 
| A set of clinical biomarkers | Serum levels lof Homocysteine; Creatinine, Creatine kinase (ck); creatine kinase MB (ck-mb); Troponin t; aspartate aminotransferase; alanine aminotransferase; and complete blood count. | 16 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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aerobic interval training, biomarkers