Study of the Relationship Between Sleep Quality and Daytime-Nighttime Variations of Blood Pressure and Plasma Glucose Type I

Study Overview
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Brief Summary
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The primary objectives are to compare the mean levels of the sleep quality parameters of subjects : with a nocturnal fall of the SBP (Systolic blood pressure), DBP (diastolic blood pressure) and MAP (mean arterial pressure) over of egal to 10% (dipping subjects) and of subjects with a nocturnal fall of SBP, DBP and MAP inferior to 10% (non dipper subjects). The secondary objectives are : Establish correlations between: The quality of sleep parameters The parameters of BP variations between the diurnal and nocturnal periods and the awake periods of sleep defined in reference to polysomnography. The glycemia levels on 24h with a glycemic holter. The parameters of the sympathic system activation evaluated in reference to the measure of the baroreflex sensibility during the awake period.

Detailed Description
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It is a prospective monocentric study after a preliminary period of depistage of the sleep abnormalities by oximetry at home. The patient would be hospitalized for two consecutive days (J0, J1). And the following evaluations will be done: Nocturnal oxymetric + Epworth questionnaire + clinical questionnaire to detect sleep perturbations at home. Blood pressure + heart rate measure Ambulatory blood pressure monitoring on 24 hours Polysomnographic measurements during the J0-J1 night spend at the hospital. Questionnaire of sleep quality and of quality of life. Glycemic measurements on 24h (J0-J1). Measure of the baroreflex sensibility during the awake period at J1. Electrocardiogram Biological examinations (blood and urinary).

Official Title
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Study of the Relationship Between Sleep Quality and Daytime-Nighttime Variations of Blood Pressure and Plasma Glucose Type I

Conditions
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Type 1 Diabetes

Intervention / Treatment
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* Biological: Biological examinations (blood and urinary).


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Male and female patients between 18 and 60 years of age Who have given their written consent to participate in this study Who are affiliated to the French social security system Are able to travel to Grenoble University Hospital Type I diabetes in reference to the 1997 criteria (American Diabetes Association) without any recent cetoacidosis or severe hypoglycaemia during the previous month and with a HbA1c < 10% during the previous month. Normal blood pressure or essential hypertension light or moderate (SBP) at rest in the sitting position >= 140 mmHg and < 180 mmHg and/or PAD >= 90 mmHg et < 110 mmHg), with or without treatment. Exclusion Criteria: Non stabilised diabetes with at least one episode of acidoketosis decompensation or hypoglycemic coma during the previous month. Diabetic nephropathy patent stage 4 with a creatinine > 150 mol / L and / or creatinine clearance <50 ml / min Diabetic nephropathy in evolution Severe hypertension (SBP at rest in the sitting position >= 180 mmHg and/or DBP >= 110 mmHg)

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Screening
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Biological: Biological examinations (blood and urinary).|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Polysomnographic measurements during the D0-D1 night spend at the hospital |  | inclusion visit | 
| Ambulatory blood pressure monitoring on 24 hours |  | inclusion visit | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Glycemic measurements on 24h (D0-D1). |  | inclusion visit | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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diapasom, sleep quality, type I diabete, blood pressure, plasma glucose, daytime and nighttime variations