Non-surgical Peridontal Treatment on Cardiovascular Risk Markers

Study Overview
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Brief Summary
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The study evaluates the influence of non-surgical mechanical periodontal treatment in patients with severe chronic periodontitis on inflammatory markers related to risk for cardiovascular diseases

Detailed Description
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A total of 80 non-smokers with systemically healthy, including 40 patients with severe chronic periodontitis and 40 periodontally health subjects were included into the present study. The probing depth, clinical attachment level, plaque index, gingival index and blood samples were collected at baseline and at the 3rd months after treatment and the serum levels of asymmetric dimethylarginine (ADMA), endothelial nitric oxide synthase (eNOS), homocysteine (Hcy), monocyte chemoattractant protein-1 (MCP-1) were determined with enzyme-linked immunosorbent assay (ELISA).

Official Title
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Effect of Non-surgical Peridontal Treatment on Cardiovascular Risk Markers in Patients With Severe Chronic Periodontitis

Conditions
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Cardiovascular Risk Markers, Chronic Periodontitis

Intervention / Treatment
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* Other: Non-surgical periodontal treatment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Clinical diagnosis of severe chronic periodontitis Clinical diagnosis of periodontal health Exclusion Criteria: Systemic diseases such as diabetes, cardiovascular disease Periodontal treatment within the previous year Drugs such as systemic steroids, non-steroidal anti-inflammatory drugs, immunosuppressants, hormone drugs, contraceptives, anticoagulants, cholesterol regulating drugs, systemic antibiotics, antioxidants within the previous 3 months Pregnant or lactating Consumed alcohol Smoker

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 54 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Non-surgical peridontal treatment<br>Patients with chronic periodontitis received non-surgical periodontal treatment, including scaling and root planing and polishing within 14 days under local anesthesia with manual and ultrasonic devices and standardized oral hygiene instructions including methods of tooth-brushing and interdental cleaning were also given to each one. A professional supragingival plaque control was applied on a regular basis every month. | Other: Non-surgical periodontal treatment<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Asymmetric dimethylarginine (ADMA) | Serum Concentration (pg/mL) | At the 3rd months after non-surgical periodontal treatment | 
| Endothelial nitric oxide synthase (eNOS) | Serum Concentration (pg/mL) | At the 3rd months after non-surgical periodontal treatment | 
| Homocysteine (Hcy) | Serum Concentration (nmol/mL) | At the 3rd months after non-surgical periodontal treatment | 
| Monocyte chemoattractant protein-1 (MCP-1) | Serum Concentration (ng/mL) | At the 3rd months after non-surgical periodontal treatment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical periodontal parameter | Clinical attachment level (mm) | At the 3rd months after non-surgical periodontal treatment | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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asymmetric dimethylarginine, endothelial nitric oxide synthase, homocysteine, monocyte chemoattractant protein-1