Cohort Study on the Outcome and Influencing Factors of Perinatal Depression

Study Overview
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Brief Summary
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Research and follow-up of the course and outcome of high-risk pregnant women with perinatal depression in the third trimester; Factors affecting the outcome of the disease; Recurrence of PND in pregnancy again; The influence of different intervention methods on the course of the disease.

Detailed Description
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Research objectives Research and follow-up of the course and outcome of high-risk pregnant women with perinatal depression in the third trimester; Factors affecting the outcome of the disease; Recurrence of PND in pregnancy again; The influence of different intervention methods on the course of the disease. Research process: 1. The pregnant women who were filed at Xinhua Hospital and Tongji Hospital and were receiving perinatal care from July 2019 to December 2019 were evaluated in the third trimester of pregnancy using the General Situation Questionnaire, SSRS, PHQ-9, and GAD-7. Those with PHQ-9 score ≥ 5 or GAD ≥ 5 were classified as having symptoms of depression and anxiety, and those who were screened positive were included in the study cohort; 42 days postpartum, 3 months postpartum, 6 months postpartum, 12 months postpartum, 18 months postpartum , 24 months postpartum, use PHQ-9, GAD-7 scale, 6 quality of life questionnaires, and SSRS to evaluate the cohort. If the PHQ-9 score is greater than or equal to 5 or the GAD is greater than or equal to 5, the psychiatrist will perform a clinical examination based on DSM-IV to make a clinical diagnosis; the outcome of the cohort and the incidence and influencing factors; 2 . During the follow-up process, the cohort developed high-risk pregnant women with depression, anxiety symptoms and other perinatal depressive disorders during the follow-up process. Based on the WeChat platform, integrated general hospitals, psychological counseling centers, social families and other service resources were carried out throughout the prenatal and first delivery period. Intervention methods such as community intervention for perinatal depression that focus on the comprehensive physiology, psychology, and society of the whole process after the first childbirth. Pregnant women diagnosed with PND will be evaluated by a psychiatrist to determine the treatment plan, and follow-up will continue.

Official Title
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A Cohort Study on the Outcome and Influencing Factors of High-risk Pregnant Women With Perinatal Depression in the Third Trimester

Conditions
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Perinatal Depression, Prognosis

Intervention / Treatment
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* Behavioral: Psychological intervention
* Other: Comprehensive intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: - Exclusion Criteria: -
Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Drug intervention<br>Antidepressant | Behavioral: Psychological intervention<br>* Choose according to the wishes of the enrolled subjects and the results of the evaluation<br>Other: Comprehensive intervention<br>* Choose according to the wishes of the enrolled subjects and the results of the evaluation<br>|
| Psychological intervention<br>Cognitive behavior therapy, sand table therapy | |
| Comprehensive intervention<br>Psychological intervention, community intervention combined with drug intervention | Behavioral: Psychological intervention<br>* Choose according to the wishes of the enrolled subjects and the results of the evaluation<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fate | Progression of high-risk pregnant women with perinatal depression in the third trimester | 2019.9.1-2022.2.1 | 
| Influencing factors | Influencing factors of disease progression | 2019.9.1-2022.2.1 | 
| Impact of intervention | The influence of different intervention methods on the course of the disease | 2019.9.1-2022.2.1 |