Oxaliplatin, Capecitabine, and Bevacizumab Followed By Surgery and/or Radiofrequency Ablation in Patients With Colorectal Cancer

Study Overview
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Brief Summary
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RATIONALE: Drugs used in chemotherapy, such as oxaliplatin and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Bevacizumab may also stop the growth of tumor cells by blocking blood flow to the tumor. Radiofrequency ablation uses a high-frequency, electric current to kill tumor cells. Giving chemotherapy and bevacizumab before surgery or radiofrequency ablation may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. PURPOSE: This phase II trial is studying how well giving oxaliplatin and capecitabine together with bevacizumab followed by surgery and/or radiofrequency ablation works in treating patients with colorectal cancer that has spread to the liver and cannot be removed by surgery.

Detailed Description
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OBJECTIVES: Primary Evaluate the conversion rate of nonresectable disease to resectable disease in patients with nonresectable liver metastases secondary to colorectal adenocarcinoma treated with neoadjuvant therapy comprising oxaliplatin, capecitabine, and bevacizumab followed by hepatic resection and/or radiofrequency ablation. Evaluate progression-free survival of patients treated with this regimen. Secondary Determine disease-free and overall survival of patients treated with this regimen. Determine the toxicities of this regimen in these patients. OUTLINE: Neoadjuvant therapy: Patients receive oxaliplatin IV over 2 hours and bevacizumab IV over 1 hour on day 1 and oral capecitabine twice daily on days 1-14. Treatment repeats every 3 weeks for 4-6 courses in the absence of disease progression or unacceptable toxicity or until conversion to resectable disease. Surgery and/or radiofrequency ablation (RFA): Patients undergo hepatic resection (with or without RFA) when tumor is deemed resectable. Patients with stable (< 8 lesions) and unresectable disease undergo laparoscopic or percutaneous RFA. RFA repeats once 4-6 weeks later. Adjuvant therapy: Beginning 6-8 weeks after surgery and/or RFA, patients may receive adjuvant therapy comprising oxaliplatin, capecitabine, and bevacizumab, as in neoadjuvant therapy, for up to 4 courses. After completion of study treatment, patients are followed every 4 months. PROJECTED ACCRUAL: A total of 40 patients will be accrued for this study.

Official Title
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Efficacy of Neoadjuvant XELOX/AVASTIN Therapy for Nonresectable Colorectal Liver Metastases With Secondary Hepatic Resection/Radiofrequency

Conditions
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Colorectal Cancer, Metastatic Cancer

Intervention / Treatment
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* Biological: bevacizumab
* Drug: capecitabine
* Drug: oxaliplatin
* Procedure: conventional surgery
* Procedure: neoadjuvant therapy
* Procedure: radiofrequency ablation


Participation Criteria
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Eligibility Criteria
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DISEASE CHARACTERISTICS: Histologically confirmed colorectal adenocarcinoma metastatic to the liver Unresectable liver metastases Measurable disease No evidence of extrahepatic metastases No CNS metastases PATIENT CHARACTERISTICS: ECOG performance status 0-1 Absolute neutrophil count > 1,500/mm^3 Platelet count > 100,000/mm^3 Creatinine ≤ 1.5 times upper limit of normal (ULN) OR creatinine clearance ≥ 45 mL/min Urinary protein < 2+ by dipstick OR < 2 g by 24-hour urine collection Bilirubin < 2 times ULN SGOT and SGPT < 2 times ULN Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception during and for 18 months after completion of study therapy Able to take oral medications (e.g., no dysphagia or malabsorption symptoms) No other prior malignancy unless in complete remission and off therapy for ≥ 5 years No known allergy to the study drugs No peripheral neuropathy > grade 1 No uncontrolled infection No uncontrolled hypertension No active bleeding or hemoptysis No other serious concurrent illness within the past 12 months, including any of the following: Nonstable coronary artery disease Myocardial infarction Transient ischemic attack Cardiovascular accident PRIOR CONCURRENT THERAPY: Recovered from prior therapy At least 28 days since prior major surgery Prior therapy for advanced disease allowed No prior oxaliplatin-based therapy Concurrent maintenance and palliative treatment during study chemotherapy allowed (e.g., nutritional or transfusional support or pain control) No concurrent corticosteroids except when used under the following circumstances: As oxaliplatin premedication Anti-5-HT_3 as antiemetic No concurrent cold cap or iced mouth rinses No other concurrent chemotherapy No placement of hepatic artery port for regional chemotherapy

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 120 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Unresectable colorectal liver mets<br> | Biological: bevacizumab<br> <br> Drug: capecitabine<br> <br> Drug: oxaliplatin<br> <br> Procedure: conventional surgery<br> <br> Procedure: neoadjuvant therapy<br> <br> Procedure: radiofrequency ablation<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Conversion rate of nonresectable disease to resectable disease |  | 48 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Disease-free and overall survival |  | 48 months | 
| Objective response rate |  | 48 months | 
| Duration of response |  | 48 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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liver metastases, stage IV colon cancer, stage IV rectal cancer, adenocarcinoma of the colon, adenocarcinoma of the rectum, recurrent colon cancer, recurrent rectal cancer