linjc16/ctgov huggingface dataset:
Detection of Choroidal Nevus Cells in Vitrectomy Fluid

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine if the investigators can detect the presence of choroidal nevi cells in the vitreous fluid of humans, as this may improve the diagnosis and classification of choroidal nevi and melanomas in the future.

Detailed Description
-----------------
Approximately 7% of the population has a choroidal nevus, or freckle, in the back of the eye. Like a nevus on the skin, there is potential for malignant change to a melanoma. Dermatologists have the ability to quickly and easily biopsy suspicious skin lesions while ophthalmologists currently have no way of determining the malignant potential of choroidal nevi other than a fine needle aspiration (which is invasive and has the potential complications of bleeding and retinal detachment). This study's sole aim is to see if choroidal nevi cells are present in the inside fluid of the eye. The investigators plan to analyze the fluid of the eye, which is routinely removed during retina surgery, to detect any nevus cells. If the investigators are able to detect these cells, then future studies may allow us to better classify choroidal nevi for potential malignant change.

Official Title
-----------------
Detection of Choroidal Nevus Cells in Vitrectomy Fluid

Conditions
-----------------
Nevus

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with a choroidal nevus who are undergoing routine vitrectomy surgery for another indication (such as epiretinal membrane or macular hole repair). Exclusion Criteria: Patients without a choroidal nevus Children under the age of 18 Pregnant and nursing females

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Positive identification of nevus cells in eye fluid |  | 1 day | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
choroidal nevus, vitrectomy
An Evaluation of the Nighttime Retention of Effect of an Investigational Lubricant Eye Drop (FID 115958D)

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to describe the night-time use of an investigational lubricant eye drop.

Conditions
-----------------
Dry Eye

Intervention / Treatment
-----------------
* Other: FID 115958D (lubricant eye drop)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Documented diagnosis of dry eye Current use of an eye ointment or tube gel Exclusion Criteria: No nighttime contact lenses wear throughout the study period Must not have had punctal plugs inserted within 30 days preceding enrollment

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: FID 115958D<br>Lubricant eye drop | Other: FID 115958D (lubricant eye drop)<br>* 1 drop in each eye at bedtime<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Nighttime Use Assessment | Nighttime Use Assessment: I would use this product at bedtime for my dry eye symptoms Likert scale (i.e. strongly disagree, disagree, neither disagree nor agree, agree, strongly agree) | Day 7 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Dry eye, artificial tears
Relative Bioavailability Study of Nadolol (1 x 80 mg) Tablets Under Fasting Conditions

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to demonstrate the relative bioavailability of Nadolol (1 x 80 mg) tablets under fasting conditions.

Official Title
-----------------
A Relative Bioavailability Study of Nadolol (1 x 80 mg) Tablets Under Fasting Conditions.

Conditions
-----------------
High Blood Pressure, Migraine Headaches, Chest Pain

Intervention / Treatment
-----------------
* Drug: Nadolol (1 x 80 mg) Tablets (Invamed, Inc)
* Drug: Corgard (1 x 80 mg) Tablets (Bristol Laboratories)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: No clinically significant abnormal finding on physical exam, medical history, or clinical laboratory results on screening. Exclusion Criteria: Positive test results for HIV or hepatitis B or C. Treatment for drug or alcohol dependence.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>Nadolol (1 x 80 mg) Tablets (Invamed, Inc) | Drug: Nadolol (1 x 80 mg) Tablets (Invamed, Inc)<br> <br> |
| Active Comparator: 2<br>Corgard (1 x 80 mg) Tablets (Bristol Laboratories) | Drug: Corgard (1 x 80 mg) Tablets (Bristol Laboratories)<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Bioequivalence based on AUC and Cmax |  | 21 days |
PCR (Polymerase Chain Reaction) Assay for Diagnosis of Sarcoptes Scabiei

Study Overview
=================
Brief Summary
-----------------
The main objective of this study is to identify unique DNA sequences within the genome of human scabies that can be utilized to identify the parasite through PCR.

Detailed Description
-----------------
The main objective of this proposed study is to identify unique DNA sequences within the genome of human scabies that can be utilized to identify the parasite through polymerase chain reaction or PCR. The goal of the project is to design an assay that can distinguish samples from skin scrapings containing scabies mites, eggs, or fecal material confirmed by clinic based microscopic evaluation (gold standard) from negative controls (i.e. scrapings for tinea and/or demodex folliculitis) that do not contain Sarcoptes scabiei. We hypothesize that specifically amplifying the unique regions of the Scabies genome using PCR can serve as a means to diagnosis infestations in humans. To address this question, we will optimize PCR amplification of known scabies samples then apply our procedure to DNA extracted from patient samples.

Official Title
-----------------
PCR (Polymerase Chain Reaction) Assay for Diagnosis of Sarcoptes Scabiei

Conditions
-----------------
Scabies

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 1. Male/Female of all ages whose standard clinical treatment produces one or more of the following: Slides from skin scrapings containing scabies mites, eggs, and/or fecal material Slides from skin scrapings of suspected tinea Slides from skin scrapings of demodex mites Exclusion Criteria: 1. Patients who are clinically concerning for having both scabies and tinea/demodex folliculitis to avoid contamination of positive and negative controls in the same sample. Subjects or guardians who cannot understand and read English and so are unable to consent to participation.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Positive Scrapings<br>Skin scrapings that are positive for scabies | |
| Negative Controls<br>collect negative controls from patients in whom tinea (superficial fungal infection) was clinically suspected. Samples from patients with demodex folliculitis (a mite that is commonly found in oil glands on the face) are also intended to be used as negative controls as well. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Identification of DNA sequences within scabies that can be used to identify the parasite through PCR |  | 1 year |
Attitudes Behavior and Practices of Mothering Among an Online Panel

Study Overview
=================
Brief Summary
-----------------
Subjects are users on Amazon's Mechanical Turk (MTurk) platform. MTurk users will be asked to complete a screening survey about family structure. The purpose of the screening survey is to identify MTurk users who are biological mothers of children aged 1.5 to 6 years old, and to collect survey information on how mothers interact with their children, with the aim of better understanding family relationships.

Detailed Description
-----------------
This is a feasibility study that aims to identify a panel of biological mothers of children aged 1.5 to 6 years old from an online pool of participants on Amazon's Mechanical Turk (MTurk; www.mturk.com). MTurk is a novel method to recruit participants from online behavioral studies. Although MTurk workers are anonymous, demographic surveys from previous studies conducted on the web platform indicate that the majority of MTurk users are females living in the U.S. The participant pool may be of scientific interest in pursuing studies that investigate patterns of behaviors and other information pertaining to mothers. A panel of mothers that fit screening criteria may be helpful for future planned studies on attitudes, behavior, and practices surrounding mothering. The MTurk mothers panel will be eligible to participate in future studies involving knowledge, attitudes, and practices of their motherhood and of emotional connection with their children.

Official Title
-----------------
Attitudes Behavior and Practices of Mothering Among an Online Panel

Conditions
-----------------
Tantrum, Relation, Family, Parent-Child Relations, Parenting

Intervention / Treatment
-----------------
* Other: Online Survey completion


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Biological mothers of children between ages 1.5-6 living in the US Exclusion Criteria: Not having reliable internet access

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
-----------------
Female

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Online Survey completion|Eligible participants will complete surveys electronically via Amazon's mTurk platform|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlations between survey items | Descriptive statistics and correlations will be generated to show the basic participant characteristics captured during the data collection and whether the survey items correlate with each other. Survey items include the Parental Burnout Assessment, the Temper Loss Scale, and two surveys created by Dr. Welch at the Nurture Science Program: the Welch Emotional Connection Screen-Parent Report, as well as a tantrum questionnaire. | Day 1 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
MTurk
Lidocaine In-situ Gel Prior to Intrauterine Device Insertion in Women With no Previous Vaginal Delivery

Study Overview
=================
Brief Summary
-----------------
Long-acting reversible contraception methods are highly effective methods for reduction of the unplanned pregnancy rate worldwide. The intrauterine device is a single procedure that provides reliable, effective and long term contraception for many women. However, the insertion procedure can be associated with a troublesome degree of pain that prevent some women from choosing its use. Different interventions have been described to decrease pain perception during intrauterine device insertion with no agreement on an effective one. Pre-insertion oral ibuprofen, diclofenac, nitroprusside, local anesthetics as lidocaine and prostaglandins has been reported with variable degrees of success .

Official Title
-----------------
Effect of Self-administered Lidocaine In-situ Gel Prior to Intrauterine Device Insertion in Women With no Previous Vaginal Delivery: A Randomized Controlled Study

Conditions
-----------------
Contraception

Intervention / Treatment
-----------------
* Drug: lidocaine gel
* Drug: placebo gel


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: Non-pregnant women Women that did not receive any analgesics or misoprostol in the 24 hours prior to insertion Women who delivered only by caesarean section Exclusion criteria: Women with any uterine abnormalities as congenital anomalies, endometrial lesions, adenomyosis, fibroids Those with a Category 3 or 4 conditions for intrauterine device insertion according to the WHO Medical Eligibility Criteria for contraceptive use Allergy to lidocaine. Women refuse to participate in the study

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 49 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: lidocaine group<br>lidocaine in-situ gel inserted vaginally | Drug: lidocaine gel<br>* syringe filled with 5 ml gel to be self-administered vaginal 10 minutes prior to insertion<br>|
| Placebo Comparator: placebo group<br>placebo gel inserted vaginally | Drug: placebo gel<br>* syringe filled with 5 ml gel to be self-administered vaginal 10 minutes prior to insertion<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The difference in pain scores during intrauterine device insertion | using visual analog scale from 0 to 10 | 10 minutes |
Modified Diabetes Prevention Program in Ecuador

Study Overview
=================
Brief Summary
-----------------
This pilot study will evaluate the use of a modified (cultural and language) adaptation of the National Diabetes Prevention Program in a cohort in Quito Ecuador.

Detailed Description
-----------------
This pilot study will evaluate the use of a modified (cultural and language) adaptation of the National Diabetes Prevention Program in a cohort in Quito Ecuador. People who took the program had the option to participate in the research component. All participants selected the research component. Adaptations- the coaches will be physicians from PUCE and they will administer this program for eligible employees who have biochemical prediabetes. The program will be modified to be able to fit within the school curriculum. The diabetes prevention program will be offered in Spanish and the content modified to better fit the cultural norms for the Quito Ecuador population. Participants will be adults with prediabetes as screened by the CDC Diabetes Risk Test and confirmed by HbA1c. Outcome measures will include change in mean HbA1c, change in weight, physical activity, and attendance to the program.

Official Title
-----------------
A Pilot of a Modified Diabetes Prevention Program in Quito, Ecuador

Conditions
-----------------
PreDiabetes

Intervention / Treatment
-----------------
* Behavioral: Diabetes Prevention Program


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adults who worked at the university and had biochemical prediabetes. - Exclusion Criteria: Those with known diabetes, those unwilling to complete a 6 month intervention. -

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: Diabetes Prevention Program|This program is a 1 year lifestyle modification program focused on reducing calories and fat calories and increasing physical activity to achieve a 7% weight loss. This study utilized the first 16 sessions (6 months) of the program|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| HbA1c | measure of glucose over 90-120 days | 90-120 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Weight change | change in weight over the 6 month program | 6 months |
Non-Contact Air Tonometry (Topcon CT-1®) Versus Goldmann

Study Overview
=================
Brief Summary
-----------------
In this prospective device comparison study with 58 healthy eyes, the Topcon CT-1® showed statistically significant elevated intraocular pressure measurements compared to the gold standard Goldmann application tonometry.

Detailed Description
-----------------
Introduction: Intraocular pressure (IOP) measurement is crucial in glaucoma diagnosis and treatment. We compared a non-contact air tonometer (Topcon CT-1®) with the gold standard Goldmann Applikation tonometer (GAT). Methods: In this prospective, mono centric device comparison study, only healthy eyes were enrolled. IOP was measured three times with the Topcon CT-1® followed by three times GAT. Mean IOP was calculated and compared with a paired t-test, a linear regression and a Bland-Altman analysis.

Official Title
-----------------
Non-Contact Air Tonometry (Topcon CT-1®) Versus Goldmann Applanation Tonometry: a Device Comparison Study

Conditions
-----------------
Glaucoma

Intervention / Treatment
-----------------
* Device: Intraocular pressure measurement


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy volunteers who agreed to be included in the study and were able to comply with the measurement procedures Exclusion criteria were cor-neal abnormalities (such as oedema, scars or dystrophies, astigmatism,hyperopia or myopia > 3 dioptres), a history of ocular surgery or recent(<47 weeks) ocular disorder.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 99 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: Intraocular pressure measurement|Pressure tip or air puff is applied on eye|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of GAT with air tonometry Topcon CT1 | Difference in mmHg between these two devices | 7 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Tonometry
Trial to Evaluate Erectile Function, Fertility and Sperm Count in Male Cyclists Compared to Age Matched Controls

Study Overview
=================
Brief Summary
-----------------
Bicycle riding is associated with related diverse urogenital symptoms ranging from genital numbness to erectile dysfunction (ED). Very little is known about the quality of sperm in cyclists and whether a connection exists between erectile dysfunction and azoospermia.

Official Title
-----------------
Prospective Controlled Trial to Evaluate Erectile Function, Fertility and Sperm Count in Male Cyclists Compared to Age Matched Controls

Conditions
-----------------
Erectile Dysfunction, Azoospermia

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Males ages 20-35, with at least 2 years of bicycle riding, at least 2 hours a week. Exclusion Criteria: History of prostatic surgery, testicular surgery, or single testis, Patients after chemotherapy, Patients receiving hormonal therapy, Patients receiving alpha blockers for any indication.

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 35 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
cyclist
Early Detection and Staging of Endobronchial Lung and Pleural Cancer, Airway Injury, and Prostate Cancer

Study Overview
=================
Brief Summary
-----------------
This study has been designed to utilize already obtained biopsy specimens for investigation of the utility of a new, non-invasive optical diagnostic technique. The study will allow a careful correlation between the Optical coherence tomography findings and conventional histology.

Detailed Description
-----------------
Optical coherence tomography is a non-invasive diagnostic technique that can provide information about tissue abnormalities, change in structure of an organ. This technique uses a near-infrared diode to emit light that can produce images of the specimen under investigation without causing damage or alterations.

Official Title
-----------------
Optical Coherence Tomography for Early Detection and Staging of Endobronchial Lung and Pleural Cancer, Airway Injury, and Prostate Cancer

Conditions
-----------------
Lung Cancer, Pleural Cancer, Prostate Cancer

Intervention / Treatment
-----------------
* Device: diagnostic


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adult 18 years and older Having procedure of endobronchial, transbronchial, and / or pleural biopsy Exclusion Criteria: Currently participating in any other investigational drug or device evaluation. Currently taking drugs that are sensitive to light.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| diagnostic<br>oct imaging | Device: diagnostic<br>* oct imaging<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pathology results. |  | 30 minutes | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
early detection of lung and pleural cancer, early detection of prostate cancer