Neural Signatures of Processing the Temporal Features of Auditory Events: From Preterm Infancy to Adulthood

Study Overview
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Brief Summary
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Premature neonates are able to discriminate phonemes and voice from 28wGA at a time the neuronal network establish contact between the environment and the cortical neurones. In the present monocentric study the investigators will analyse the response of the cortical network in premature aged between 25 and 36 wGA in response to auditory stimuli using High Resolution Electroencephalography and High Density Near Infrared Spectroscopy.

Detailed Description
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Neurodevelopmental disorders may be related to functional or structural disruption of the neuronal network organization at an early stage or later in the course of development. The disruption of the initial set-up could partially explain the prevalence of neurodevelopmental risks due to prematurity. The development period between 25 and 33 wGA corresponds to the period of very great prematurity and represents a key period of neurodevelopment in terms of structural and functional establishment of neuronal networks. One way to address the functionality of the neuronal networks is to evaluate the neural response to the exogenous stimuli and to interpret the mechanisms and the developmental status of the network in their ability to develop appropriate responses.

Official Title
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Neural Signatures of Processing the Temporal Features of Auditory Events: From Preterm Infancy to Adulthood

Conditions
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Time Perception, EEG, Premature Neonates, Discrimination

Intervention / Treatment
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* Procedure: EEG
* Procedure: NIRS


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: full term neonates between 25 and 36 weeks gestational age Exclusion Criteria: Neonates outside the age range

Ages Eligible for Study
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Minimum Age: 0 Days
Maximum Age: 1 Day

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: normal 25-36 gestational week preterm infant<br> | Procedure: EEG<br>* Response of the cortical network in premature aged between 25 and 36 wGA in response to auditory stimuli using High Resolution Electroencephalography will be performed<br>Procedure: NIRS<br>* Response of the cortical network in premature aged between 25 and 36 wGA in response to auditory stimuli using High Density Near Infrared Spectroscopy will be performed<br>|
| Experimental: 25-36 gestational week preterm infant with IVH<br>25-36 gestational week preterm infant with Intraventricular haemorrhages (IVH) | Procedure: EEG<br>* Response of the cortical network in premature aged between 25 and 36 wGA in response to auditory stimuli using High Resolution Electroencephalography will be performed<br>Procedure: NIRS<br>* Response of the cortical network in premature aged between 25 and 36 wGA in response to auditory stimuli using High Density Near Infrared Spectroscopy will be performed<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| measure at which age the ability to discriminate time features occurs in premature neonates with Matlab Friedtrip toolbox | measure at which age the ability to discriminate time features occurs in premature neonates. For the analysis of discrimination, the investigators will use cluster analysis as implemented in the Matlab Friedtrip toolbox. | at day 0 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| variation of the ability to discriminate time features between the IVH and normal preterm groups with BESA statistical tools | variation of the ability to discriminate time features between the IVH and normal preterm groups. For the analysis of time-frequency responses, the investigators will use cluster randomization procedures as implemented in the BESA statistical tools. | at day 0 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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time perception, rhythm, EEG, fNIRS, ERP, premature neonates, discrimination