Validity of SOFA Score as Predictor of Mortality in Critically-ill Burn Patients

Study Overview
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Brief Summary
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SOFA score is valid for mortality predictor for critically-ill patient in high care and intensive care burn unit

Official Title
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Validity of Sequential Organ Failure Assessment (SOFA) Score as Predictor of Mortality in Critically-ill Burn Patients

Conditions
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Mortality Prediction

Intervention / Treatment
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* Other: SOFA score


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: adult patients (age 18 and above) who admitted to burn unit during sampling period Exclusion Criteria: patients discharged or deceased less than 24 hours of admission patients referred to other hospital within 30 days admission

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Mortality outcome<br> | Other: SOFA score<br>* Variables of sequential organ failure assessment score, including: P:F ratio; MAP or vasoactive treatment; creatinine or 24-h diuresis; platelet count; serum bilirubin; GCS.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| SOFA score Discrimination | SOFA score ability to discriminate outcomes based on variable scores: PaO2/FiO2; MAP/vasoactive treatment; serum creatinine or 24-h diuresis; platelet count; serum bilirubin; GCS | 30 days from admission | 
| SOFA score Calibration | SOFA score cutoff to predict outcome based on variable scores: PaO2/FiO2; MAP/vasoactive treatment; serum creatinine or 24-h diuresis; platelet count; serum bilirubin; GCS | 30 days from admission | 
| Correlation between SOFA score variables with outcome | Correlation between patient outcomes with each SOFA score variable: PaO2/FiO2; MAP/vasoactive treatment; serum creatinine or 24-h diuresis; platelet count; serum bilirubin; GCS | 30 days from admission | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patient outcome | Patient outcome within 30 days of admission to burn units: deceased or survived | 30 days from admission | 
| SOFA score: Partial Oxygen Pressure (PaO2)/ Fraction of Inspired Oxygen (FiO2) | The score for PaO2/FiO2 variable cutoff: 0 point for >400 mmHg; point for <400 mmHg; points for <300 mmHg; points for <200 mmHg with respiratory support; points for <100 mmHg with respiratory support. | Day 1 | 
| SOFA score: Mean Arterial Pressure (MAP) or vasoactive agent usage | The score for MAP or vasoactive agent usage variable cutoff: 0 point for MAP >=70 mmHg; point for MAP <70 mmHg; points for dopamine <= 5 mcg/kg/min OR dobutamine any dose; points for dopamine >5 mcg/kg/min OR norepinephrine or epinephrine <=0.1 mcg/kg/min; points for dopamine >15 mcg/kg/min OR norepinephrine or epinephrine >0.1 mcg/kg/min. | Day 1 | 
| SOFA score: Serum creatinine or 24-hour diuresis | The score for serum creatinine or 24-hour diuresis variable cutoff: 0 point for creatinine <1.2 mg/dL; point for creatinine 1.2 - 1.9 mg/dL; points for creatinine 2.0 - 3.4 mg/dL; points for creatinine 3.5 - 4.9 mg/dL OR diuresis <500 mL/24h; points for creatinine >5.0 mg/dL OR diuresis <200 mL/24h. | Day 1 | 
| SOFA score: Platelet count | The score for platelet count variable cutoff: 0 point for >=150 x10^3/mm^3; point for <150 x10^3/mm^3; points for <100 x10^3/mm^3; points for <50 x10^3/mm^3; points for <20 x10^3/mm^3. | Day 1 | 
| SOFA score: Serum Bilirubin | The score for serum bilirubin variable cutoff: 0 point for <1.2 mg/dL; point for 1.2 - 1.9 mg/dL; points for 2.0 - 5.9 mg/dL; points for 6.0 - 11.9 mg/dL; points for >12.0 mg/dL. | Day 1 | 
| SOFA score: Glasgow Coma Scale (GCS) | The score for GCS variable cutoff: 0 point for 15; point for 13 - 14; points for 10 - 12; points for 6 - 9; points for <6L. | Day 1 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Burn injury, Mortality prediction, SOFA score, Organ failure