Comparison of Anthropometric Parameters and Cardiometabolic Risk Factors Among Subjects With Overweight and Obesity

Study Overview
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Brief Summary
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The study was aimed at comparing four different anthropometric parameters to cardiometabolic risk factors in overweight and obese subjects (Body Mass Index (BMI)≥25)

Detailed Description
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the present study was focused to compare the level of statistical association among four different anthropometric parameters, body mass index (BMI), waist circumference (WC), waist to height ratio (WHtR) and neck circumference (NC) and the cardiovascular (CV) risk factors most commonly evaluated in the clinical practice such as systolic and diastolic blood pressure, and fasting glucose, lipid (triglycerides, total, High-density lipoprotein (HDL) and Low-density lipoprotein (LDL) cholesterol), insulin, Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), uric acid, 25-hydroxyvitamin D (25(OH)D), c-reactive protein (CRP), white blood cells and platelet number in a population of 1214 apparently healthy subjects with overweight and obesity subjects

Official Title
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Comparison of Different Anthropometric Parameters in Relation to Cardiometabolic Risk Factors in a Cohort of Subjects With Overweight and Obesity

Conditions
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Obesity

Intervention / Treatment
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* Other: Observational


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Overweight or obesity (BMI> 25 Kg/m2) Exclusion Criteria: Any kind of drug Hypertension Endocrine diseases (diabetes mellitus, hypo or hyperthyroidism, hypopituitarism, etc.), Chronic inflammatory diseases Renal failure Liver failure Angina pectoris Myocardial infarction and heart failure Genetic heart diseases Thrombocytopenias
Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Observational|Observational|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Body mass index | Body mass index (BMI) (expressed in kg/m^2) | baseline | 
| waist circumference | waist circumference (WC) (expressed in cm) | baseline | 
| neck circumference | neck circumference (NC) (expressed in cm) | baseline | 
| waist to height ratio | waist to height ratio (WHtR) | baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Intima-media thickness | Intima-media thickness (IMT) (expressed in mm) | baseline | 
| Blood pressure | blood pressure (BP) expressed in mmHg | baseline | 
| Total Cholesterol | Total Cholesterol (expressed in mg/dL) concentration in serum | baseline | 
| Triglyceride | Triglyceride (expressed in mg/dL) concentration in serum | baseline | 
| fasting blood glucose | fasting blood glucose (FBG) (expressed in mg/dL) concentration in serum | baseline | 
| HDL Cholesterol | HDL Cholesterol (expressed in mg/dL) concentration in serum | baseline | 
| Insulin | Insulin (expressed in mg/dL) concentration in serum | baseline | 
| Homeostasis model assessment: insulin resistance | Homeostasis model assessment: insulin resistance index (HOMA-IR) | baseline | 
| LDL Cholesterol | LDL Cholesterol (expressed in mg/dL) concentration in serum | baseline | 
| Platelets | Platelets (expressed in 10^3/µL) concentration in serum | baseline | 
| white blood cells | white blood cells (WBC) (expressed in 10^3/µL) concentration in serum | baseline | 
| Vitamin D | Vitamin D (expressed in ng/dL) concentration in serum | baseline | 
| C-reactive Protein | C-reactive Protein (CRP) (expressed in mg/dL) | baseline |