Digital Health Intervention Based on Artificial Intelligence to Support the Personalized Recovery of Long COVID Patients Affected by Fatigue (AIDA)

Study Overview
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Brief Summary
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The AIDA feasibility study builds upon mental health and technology acceptance theoretical frameworks. It examines the feasibility of a mobile-based digital program to support patients with long covid affected by fatigue. The program Adhera ® Fatigue Self-management is adapted for long covid patients.

Detailed Description
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The study will explore the usability and engagement of a digital program designed for long covid patients affected by fatigue. The digital program relies on the Adhera® personalized digital health solution that includes personalized patient education and support, monitoring using psychometrics and wearables, and mental wellbeing exercises. The patients access the mobile solution via a mobile app. A total of 15 patients will be recruited and use the mobile solution for one month.

Official Title
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AIDA - A Digital Health Intervention Based on Artificial Intelligence to Support the Personalized Recovery of Long COVID Patients: Feasibility Study.

Conditions
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Post Acute COVID-19 Syndrome

Intervention / Treatment
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* Behavioral: Adhera® Fatigue for Long COVID program


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Legal adults (older than 18) Long COVID diagnosis within the last year In possession of a compatible smartphone (Android OS v4.4 or higher) Reporting any of these symptoms: Fatigue Dyspnea Anxiety Stress Depression Sleep disorder Exclusion Criteria: Hospital admission during follow-up due to pathology not related to COVID-19 Patients without digital literacy or who cannot use the mobile application. Known severe psychiatric illness or cognitive impairment Being pregnant (or suspected to be pregnant)

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Long COVID prospective group<br> | Behavioral: Adhera® Fatigue for Long COVID program<br>* Adhera® for the Long COVID program, which includes an application and a smartwatch, supported by digital health solution based on emotional and behavioral change techniques. Patient Adaptative Self-Management Content (e.g. psycho-educational content, activities for mental wellbeing, personalized motivational messages), and the personalization is based on Adhera® Health Recommender System. Wearable devices and the mobile app will be used to collect real-time data for 4 weeks to detect biometric and psychometric (patient-reported outcomes) information.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Behavioral outcome: Usability | mHealth solution usability assessed with the System Usability Scale (SUS) questionnaire. SUS can range between 0 and 100 scores, with higher values representing higher usability. | At week 4 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Long COVID, mhealth, digital health, emotional health, behavioral intervention, mental wellbeing, mood disturbance, emotional adjustment