Study of Polymorphisms of RAAS and MMPs in Acute Heart Failure

Study Overview
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Brief Summary
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this study aim to investigate the: association of RAAS polymorphisms and AHF association of MMP 3 and 12 polymorphisms and AHF

Detailed Description
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Heart failure can be defined as a complex clinical syndrome that results from any structural or functional disorder of the heart, with impairment of ability to fill the ventricles or eject blood. The main event of the IC is dyspnea and fatigue, which limit exercise tolerance and induces water retention. The renin angiotensin aldosterone system governs the salt and water homeostasis in the body. Renin is a proteolytic enzyme secreted by the juxtaglomerular apparatus of the kidney (area near the glomeruli). Renin has no direct action on the organism, but that is part of the renin-angiotensin system or the renin-angiotensin-aldosterone system is known. To date, few published studies have examined the association between the polymorphism AGT M235T * and cardiac dysfunction; and available results are contradictory. What is not known yet is the ratio of this polymorphism with the prognosis of heart failure.

Official Title
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Study of Polymorphisms of Renin Angiotensin Aldosteron Systemv(RAAS) and Matrice Metallo Protesase (MMPs) in Acute Heart Failure (AHF)

Conditions
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Acute Heart Failure

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: aged more than 18 year old. acute non traumatic dyspnea . Exclusion Criteria: ECG diagnostic for acute myocardial infarction or ischemic chest pain within the prior 24 hours a history of a heart transplant, pericardial effusion, chest wall deformity suspected of causing dyspnea coma, shock,MV,vasopressor drugs arrhythmia serious and sustained, pace maker severe mitral valve disease,

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| acute heart failure (AHF)<br>patients consulting the emergency department for dyspnea. the diagnosis of AHF was based on clinical, biological (BNP) and echocardiographic data. | |
| Non acute heart failure (NAHF)<br>patients consulting the emergency department for dyspnea. the diagnosis of AHF was based on clinical, biological (BNP) and echocardiographic data. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| mortality RAAS | the association between RAAS genes polymorphisms and mortality at one year average | one year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| association between RAAS polymorphism and AHF | the association between the diagnosis of AHF (based on clinical, BNP, and echocardiographic finds) and the RAAS genes polymorphism is studied at patient admission for acute dyspnea. | at admission (an average of 1 day) | 
| association between MMP polymorphism and AHF | the association between the diagnosis of AHF (based on clinical, BNP, and echocardiographic finds) and the MMP genes polymorphism is studied at patient admission for acute dyspnea. | at admission (average of 1 day) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Acute heart failure, RAAS, MMP3, MMP12, Polymorphysm