Physiological Factors That Influence Maintenance of Lifestyle Changes and Weight Loss - a Longitudinal Study

Study Overview
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Brief Summary
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In Denmark and the western world, there is an increasing prevalence of obesity probably due to a combination of inadequate daily physical activity and a high energy intake. One approach to achieve weight loss and change life style is to participate in an intensive supervised prolonged life style modification course. The immediate effect is often positive, but over time the overall effect is limited as the majority will not maintain weight loss and a changed life style. The purpose of this study is therefore to characterize the physiological factors that determine/influence the capacity to maintain weight loss and a healthy lifestyle after a prolonged lifestyle intervention. We have the following research questions: Are there physiological traits and characteristics that mediate better adherence to lifestyle changes and weight loss? Does the adaptation in muscle oxidative capacity after lifestyle intervention predict success in maintaining weight loss and lifestyle changes 3, 12 and 39 months after intervention? How does gender and age influence the capacity to maintain the lifestyle induced adaptation in muscle and adipose tissue and maintaining weight loss? The study design is a longitudinal intervention and will be based on a lifestyle intervention, as it is practiced in a real life setting at Ubberup folk high school.

Official Title
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Physiological Factors That Influence Maintenance of Lifestyle Changes and Weight Loss - a Longitudinal Study

Conditions
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Obesity, Overweight

Intervention / Treatment
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* Behavioral: Intensive Lifestyle Intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Participants at Ubberup Folk High School Exclusion Criteria: Previous Gastric Bypass Surgery or Gastric Banding BMI<25

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Intensive Lifestyle Intervention<br>Intensive Lifestyle Intervention at Ubberup Folk High School for 10-14 weeks. Daily exercise for 1-3hrs. Calorie restriction ( -700KCal/day). Education within nutrition, exercise and healthy living in general. | Behavioral: Intensive Lifestyle Intervention<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Total body weight |  | Changes from baseline at 3, 6, 15 and 39 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Maximal fat oxidation during exercise | Respiratory Exchange Ratio (RER) is measured and maximal fat oxidation is calculated. | Changes from baseline at 3, 6, 15 and 39 months | 
| Anthropometry | Body composition measured by dual x-ray absorptiometry or bio-impedance, height, weight, waist circumference. | Changes from baseline at 3, 6, 15 and 39 months | 
| Maximal Oxygen Consumption |  | Changes from baseline at 3, 6, 15 and 39 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Lifestyle intervention, Body weight, Body composition, Weight loss maintenance, Physical activity