HCV Viral Hepatitis, Blood Sugar Level and Systolic Blood Pressure in Egypt

Study Overview
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Brief Summary
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An observational double-blind cohort study that examined the association between HCV viral hepatitis, blood sugar level and systolic blood pressure in the Egyptian population

Detailed Description
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a cohort study on greater than 70000 Egyptian patients had been conducted. for all patients,1- we detected the Hepatitis C Virus (HCV) RNA antigens ( hepatitis C virus)presence using BIOLINE HCV kits( qualitative test for diagnosis of hepatitis C virus in the blood), For all positive patients, confirmatory rapid screening test was performed and all patients who tested positive twice underwent a qPCR test using QIAampMinElute Virus Spin kit (Thermo Fisher Scientific, Waltham, MA, USA) performed according to the manufacturer's recommended protocol. 2- Investigators measured blood sugar levels for each patient using ACCU-CHEK kits(finger stick sugar level measurement) 3- Measured systolic blood pressure for each patient was measured using mercury meters. 4-for all patients investigators obtained full medical history regarding the presence or absence of chronic diabetes, chronic hypertension, coronary artery disease, kidney impairment with dialysis or chronic obstructive pulmonary disease. 5- for all patients investigators listed age, gender, and body mass index. 66121 patients were negative for HCV and 4852 were positive for HCV. Investigators measured the association between HCV presence, high blood sugar levels and high systolic blood pressure. It is supposed that this is the largest study in the world that examined both associations. In a word, this study was responding to a specific question: is hepatitis c virus presence is associated with high blood pressure or high sugar level or both or not associated???

Official Title
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Association Between HCV Viral Hepatitis, Blood Sugar Level and Systolic Blood Pressure in the Egyptian Population

Conditions
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Hepatitis C, Acute, Diabetes, Hypertension

Intervention / Treatment
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* Diagnostic Test: BIOLINE HCV kits
* Diagnostic Test: ACCU-CHEK kits
* Diagnostic Test: ErKameter 3000 mercury manometer


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria Egyptian citizens from 18 years to 80 years. Exclusion Criteria: Patients younger than 18 years or older than 80 years

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| HCV positive patients<br>Patients tested positive for the hepatitis c virus antibodies by BIOLINE HCV kits. | Diagnostic Test: BIOLINE HCV kits<br>* We used BIOLINE HCV kits to detect the presence of HCV antibodies in stick blood samples of all recruited patients.<br>* Other names: diagnosis of viral hepatitis C;Diagnostic Test: ACCU-CHEK kits<br>* For all patients, we measured random blood sugar levels by stick blood samples using ACCU-CHEK kits.<br>* Other names: measurement of blood sugar level;Diagnostic Test: ErKameter 3000 mercury manometer<br>* For all patients, we measured systolic blood pressure using ErKameter 3000 mercury manometer.<br>* Other names: blood pressure measurement;|
| HCV negative patients<br>Patients tested negative for the hepatitis c virus antibodies by BIOLINE HCV kits. | Diagnostic Test: BIOLINE HCV kits<br>* We used BIOLINE HCV kits to detect the presence of HCV antibodies in stick blood samples of all recruited patients.<br>* Other names: diagnosis of viral hepatitis C;Diagnostic Test: ACCU-CHEK kits<br>* For all patients, we measured random blood sugar levels by stick blood samples using ACCU-CHEK kits.<br>* Other names: measurement of blood sugar level;Diagnostic Test: ErKameter 3000 mercury manometer<br>* For all patients, we measured systolic blood pressure using ErKameter 3000 mercury manometer.<br>* Other names: blood pressure measurement;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| HCV diagnosis | Detection of patients who are HCV positive or negative | 20 minutes | 
| Measurement of blood sugar level in mg/dl | Detection of the percentage of patients with high blood sugar level in HCV positive or negative patients | 1 minute | 
| Measurement of systolic blood pressure in mmHg | Detection of the percentage of patients with high systolic blood pressure in HCV positive or negative patients | 1 minute |