the Influence of Sleep Improvement Through Different Methods on Patients in ICU

Study Overview
=================
Brief Summary
-----------------
In the research, we enroll 120 postoperative patients in the ICU and they will be assigned to four group: the eye patch group, the Dexmedetomidine(DEX) group, the eye patch+DEX group and the usual group. The sleep quality would be evaluated by the EEG monitor and the metabolic level, the inflammation and nutrition status would be detected.

Detailed Description
-----------------
In the research, we enroll 120 postoperative patients in the ICU and they will be assigned to four group: the eye patch group, the Dexmedetomidine(DEX) group, the eye patch+DEX group and the usual group. The sleep quality would be evaluated by the EEG monitor and the metabolic level, the inflammation and nutrition status would be detected. The research aims to confirm that the sleep quality could have a great influence on patients in the ICU and different interventions would make various changes.

Official Title
-----------------
the Influence of Sleep Improvement Through Different Methods on Patients in ICU

Conditions
-----------------
Metabolic Problems, Sleep

Intervention / Treatment
-----------------
* Drug: Dexmedetomidine
* Device: eye patch


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: the postoperative patients that admission to icu is more than 48h Exclusion Criteria: pregnant or breastfeeding sleep disorders before operation poor liver or kidney function post craniocerebral operation

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: eye patch<br>wearing the eye patch from 22:00 to 6:00 of the next day | Device: eye patch<br>* wearing the eye patch from 22:00 to 6:00 of the next day<br>* Other names: blinders;|
| Experimental: Dexmedetomidine<br>given dexmedetomidine to meet RASS -1 from 22:00 to 6:00 of the next day | Drug: Dexmedetomidine<br>* given dexmedetomidine to meet RASS -1 from 22:00 to 6:00 of the next day<br>* Other names: Precedex;|
| Experimental: eye patch + DEX<br>given dexmedetomidine to meet RASS -1 and wearing the eye patch from 22:00 to 6:00 of the next day | Drug: Dexmedetomidine<br>* given dexmedetomidine to meet RASS -1 from 22:00 to 6:00 of the next day<br>* Other names: Precedex;Device: eye patch<br>* wearing the eye patch from 22:00 to 6:00 of the next day<br>* Other names: blinders;|
| No Intervention: usual treatment<br>treatment as usual | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the total time of sleep | using EEG records the time of sleep and different sleep phases | the first 24hours in the icu |