Dose for Deep Neuromuscular Blockade Deciding Factor of Neuromuscular Blocker Dose for Deep Neuromuscular Blockade

Study Overview
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Brief Summary
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Find out the deciding factor(total body weight, corrected body weight, ideal body weight, fat-free mass, body mass index, skeletal muscle mass, body fat) of neuromuscular blocker dose for deep neuromuscular blockade.

Detailed Description
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Before the surgery, total body weight, corrected body weight, ideal body weight, fat-free mass, body mass index were measured by height and weight and skeletal muscle mass and body fat were measured by Bioelectrical impedance analysis (InbodyH20N). Find the highest correlation between the 8 factors (total body weight, corrected body weight, ideal body weight, fat-free mass, body mass index, skeletal muscle mass, body fat) and the amount of rocuronium administered to deep neuromuscular blockade.

Official Title
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Find Out the Deciding Factor of Neuromuscular Blocker Dose for Deep Neuromuscular Blockade

Conditions
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Laparoscopic Surgery

Intervention / Treatment
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* Drug: deep neuromuscular blockade


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients aged 20-80 and American Society of Anesthesiology Physical Grade (ASA) I-II, who undergo laparoscopic surgery for at least 2 hours under general anesthesia Exclusion Criteria: kidney disease (GFR<60) allergy to study drugs decline participation side effect of propofol and remifentanil when anesthesia does not maintain the level of alertness (BIS) below 60 even when the anesthetic dose is increased, or when hemodynamic instability such as bradycardia and hypotension appears

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| deep neuromuscular blockade<br>patients who underwent surgery with deep neuromuscular blockade | Drug: deep neuromuscular blockade<br>* Train of Four=0/4, Post tetanic count 1-2<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the highest correlation coefficient | the relationship of rocuronium for deep neuromuscular blockade and 8 factors (corrected body weight, ideal body weight, lean body weight, fat-free mass, body mass index, skeletal muscle mass, body fat) | preoperative 1 days to postoperative 1 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| onset time of rocuronium | time from injection of rocuronium 0.6 mg/kg(TBW) to TOF ratio is less than 0.05 | preoperative 1 days to postoperative 1 days | 
| Time to deep neuromuscular blockade | time from injection of rocuronium 0.6 mg/kg(TBW) to PTC 1 | preoperative 1 days to postoperative 1 days | 
| Recovery time | time from sugammadex injection to TOF ratio > 0.9 | preoperative 1 days to postoperative 1 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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laparoscopic surgery, deep neuromuscular blockade