Interruption of Dorsal Visual Stream Using TMS

Study Overview
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Brief Summary
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Trans Cranial Magnetic Stimulation (TMS) over dorsal visual system will disturb the ability to identify objects with decreased level of fragmentation

Detailed Description
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The participants performed two tasks under three different TMS conditions: no TMS, 10Hz TMS for over the dorsal stream (PO3 EEG site) or over the vertex. First they performed a perceptual closure task which asked them to identify an object in a series of six progressively less degraded pictures. Then, they also performed a control task previously shown not to be mediated by the LOC and not to be impaired in schizophrenia: The perception of illusory contours.

Official Title
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Interruption of Dorsal Visual Stream Using TMS in Normal Controls

Conditions
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Healthy

Intervention / Treatment
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* Device: No TMS intervention
* Device: TMS over the PO3 EEG site
* Device: TMS over the vertex


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Normal controls Exclusion Criteria: neurological, ophthalmological or psychiatric problems family history of schizophrenia left handed

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: No TMS stimulation<br>The patients performed 2 tasks: a study and a control assignments with no TMS stimulation. | Device: No TMS intervention<br>* In the no TMS condition, no simulation was given and no coil placed near participants' heads.<br>|
| Experimental: TMS over the dorsal stream<br>The patients performed 2 tasks: a study and a control assignments under TMS stimulation over the dorsal stream area (PO3 EEG site). | Device: TMS over the PO3 EEG site<br>* 10Hz TMS over the dorsal stream (PO3 EEG site)<br>* Other names: MAGSTIM biphasic stimulator;|
| Sham Comparator: TMS over the vertex<br>The patients performed 2 tasks: a study and a control assignments under TMS stimulation over the vertex area. | Device: TMS over the vertex<br>* 10Hz TMS for over vertex.<br>* Other names: MAGSTIM biphasic stimulator;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Results of the study assignments performed by the participants during the study. | The subjects performed 2 tasks: The primary dependent measures consisted of the level of detail needed for correct object identification, response accuracy, and response time in milliseconds for correct responses. Illusory Contour Task: Subjects also performed a pulsed pedestal task, Participants were shown 55 drawings for 500 ms each. Some drawings contained partial contours which defined a geometric shape, while in others the contours did not define a shape. Participants were asked to indicate whether they recognized a geometric shape or not. Accuracy and response time were measured. | The participants performed the tasks once during their study visit | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Normal Controls