Pain-related Long Covid in Covid-19 Survivors

Study Overview
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Brief Summary
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The exploratory project aims to investigate the presence of pain as a long Covid-19 symptom in previously hospitalised patients and in non-hospitalised persons previously tested positive in a PCR test.

Detailed Description
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The main objectives investigated will be to determine the general prevalence of pain symptoms In Covid-19 survivors, correlating and analysing the role of previously comorbidities in the development of pain symptom in Covid-19 survivors, and to understand the prevalence of pain related long Covid-19 symptoms for future characterisations. Hence, the projects main outcome will be to try to understand why som Covid-19 survivors develop persistant pain and others don't. Furthermore, the project plan to analyse gender and age differences, and data between Covid-19 waves as well as any possible association between pain prevalence and time after positive PCR-test.

Official Title
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Pain-related Long Covid in Covid-19 Survivors

Conditions
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COVID-19, Pain, Chronic

Intervention / Treatment
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* Other: Questionnaire and register-based data assessment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Previously infected with SARS-CoV-2 virus Exclusion Criteria: Participants under the age of 18 Hidden/secret address/name No access to digital mail (the channel of data collection)

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Hospitalization group<br>Previously hospitalized Covid-19 survivors who have been admittet to the hospital with or because of SARS-CoV-2 infection. Time from infection date start is > 6 months. The group is anticipated to encompass 2.182 privously hospitalized adult patients. | Other: Questionnaire and register-based data assessment<br>* Primary data will be collected via a generic questionnaire from the two groups. Secondary data will consist of register-based socio-economic data and medical charts data collected from the Danish Health Data Authority and Denmark' Statistics.<br>|
| PCR+ group<br>Non-hospitalized Covid-19 survivors that has previously testet positive in an Polymerase chain reaction test without being admittet to the hospital. Time from infection data start is > 6 months. The group will include almost the total population of adults who have tested positive in a Polymerase Chain Reaction test. Those with secret adresses and those without access to digital mail (information channel of the questionnaire) will be excluded being approcimatelyh 7% of 650.000 possible participants. The group encompasses 593.741 participants. | Other: Questionnaire and register-based data assessment<br>* Primary data will be collected via a generic questionnaire from the two groups. Secondary data will consist of register-based socio-economic data and medical charts data collected from the Danish Health Data Authority and Denmark' Statistics.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Persistent pain in Covid-19 survivors | Detection of possible differences in Covid-19 survivors with or without persistent pain after a SARS-CoV-2 infection as collected via questionnaire data | Above six months after a SARS-CoV-2 infection | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The role of comorbidities in the development of persistent pain in Covid-19 survivors | Register-based medical charts from hospitalization correlated with self-reported pain from the questionnaire data | Above six months after a SARS-CoV-2 infection | 
| The role of comorbidities in the development of persistent pain in Covid-19 survivors II | Register-based data about positive PCR-test correlated with self-reported pain from the questionnaire data | Above six months after a SARS-CoV-2 infection | 
| The role of socio-economic impact on the development of persistent pain in Covid-19 survivors | Register-based data of socio-economic variables that could influence self-rated perception of pain | Above six months after a SARS-CoV-2 infection | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Covid-19, Coronavirus, Chronic Pain, Persistant pain, Long Covid, SARS-CoV-2