Management of Antithrombotic TherApy in Patients With Atrial Fibrillation or DevelOping AtRial Fibrillation During Hospitalization for PCI

Study Overview
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Brief Summary
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ACS are a potent risk factor for AF, with new onset AF occurring in up to 1 in every 5 patients hospitalized with an ACS. Despite its relatively frequent occurrence and the many etiologic factors involved in its pathogenetic condition, the frequency and prognostic significance of AF complicating ACS remain unclear

Detailed Description
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There are limited data available, particularly from a representative population-based perspective describing recent pharmacological and non-pharmacological management and clinical event rates associated with AF complicating ACS in the era of novel treatment strategies (in both AF and ACS) and high coronary reperfusion rates. This registry will assess the current in-hospital management and clinical events at 6 months of consecutive patients admitted in Italian cardiology intensive care units (CCUs) for an ACS treated invasively with PCI and stent implantation who present AF at admission or during hospital stay, before or after stent implantation .

Official Title
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Management of Antithrombotic TherApy in Patients With Atrial Fibrillation or DevelOping AtRial Fibrillation During Hospitalization for PCI

Conditions
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Acute Coronary Syndrome, Atrial Fibrillation

Intervention / Treatment
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* Other: Acute coronary syndrome and PCI and AF


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All consecutive ACS patients treated with PCI with stent implantation who present AF at admission or during hospital stay, before or after stent implantation. Exclusion Criteria: Patients admitted with a diagnosis of ACS at the time of enrolment but not confirmed during hospitalization ACS treated medically or with PCI but without stent implantation Patients not giving informed consent

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Acute Coronary Syndrome<br>Patients with Aute coronary syndrome trated with Percutaneous Coronary Intervention plus Stent implantation and Atrial Fibrillation | Other: Acute coronary syndrome and PCI and AF<br>* Patient with ACS and ACS treated with PCI<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical epidemiology | Demographics | Enrollement | 
| Management | Pharmacological treatment | 6 months | 
| Antithrombotic strategy | Intravenous or oral antiplatelet and anticoagulation therapies and their combination | 6 months | 
| Clinical epidemiology | Clinical history | Enrollement | 
| Clinical epidemiology | Type of AF | Enrollement | 
| Clinical epidemiology | Type of ACS | Enrollement | 
| Management | Time of PCI | 6 months | 
| Number of procedure performed on enrolled patients | In-hospital management | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pharmacological therapies | Use and persistence of therapies prescribed at discharge | 6 months | 
| Clinical outcomes | All cause deaths, major bleedings, non fatal stroke, systemic embolism, transiet ischemic attach, MI recurrence | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Acute Coronary Syndrome, Atrial Fibrillation, Percutaneous Coronary Intervention