Comparative Study on the Efficacy of OliNano SEAL and Curodont D' Senz in Treatment of Dentin Hypersensitivity

Study Overview
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Brief Summary
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This study was conducted to evaluate and compare the efficacy of Olinanoseal and Curodont D'Senz in treatment of dentin hypersensitivity.

Detailed Description
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Materials and Methods:- A total of ninety (90) samples were used in the study, for dentin permeability test (dye penetration test) and Scanning Electron Microscopic examination (SEM) which were randomly divided into two main groups; group A1, completely removed smear layer, group A2, partially removed smear layer. Each group was subdivided into three subgroups according to the desensitizing agent applied: OliNano SEAL, Curodont D'Senz and the control group that were left untreated. Seventy (70) hypersensitive teeth in ten patients were enrolled for the current study. The subjective assessment of dentin hypersensitivity was done prior to the application of the desensitizing agent (baseline) then immediately, 2 weeks, 4 weeks and 3 months after application of the tested materials. Patients were informed to rate their perception to tactile, air and cold stimuli by using Verbal Rating Score (VRS) and Visual Analogue Scale (VAS).

Official Title
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Comparative Study on the Efficacy of OliNano SEAL and Curodont D' Senz in Treatment of Dentin Hypersensitivity

Conditions
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Dentin Hypersensitivity

Intervention / Treatment
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* Drug: Olinanoseal
* Drug: Curodont D'senz


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Presence of a minimum of four hypersensitive teeth in each patient. Patients with teeth recorded a discomfort score of two or more to tactile, cold and air stimulation. Teeth having hypersensitivity only on the facial aspect. Patients' willingness to participate in the study Exclusion Criteria: Patients with any medical or dental condition that could impact the study results during its expected length. Patients with a history of drug addictions and use of potent analgesic and/ or anti-inflammatory drugs. Patients who refused to give their consents. Patients with any extensive or unsatisfactory restorations, prosthesis or orthodontic appliances which involve the cervical areas

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: A total of ninety (90) samples were used in the study, for dentin permeability test (dye penetration test) and Scanning Electron Microscopic examination (SEM) which were randomly divided into two main groups; group A1, completely removed smear layer, group A2, partially removed smear layer. Each group was subdivided into three subgroups according to the desensitizing agent applied: OliNano SEAL, Curodont D'Senz and the control group that were left untreated. Seventy (70) hypersensitive teeth in ten patients were enrolled for the current study. The subjective assessment of dentin hypersensitivity was done prior to the application of the desensitizing agent (baseline) then immediately, 2 weeks, 4 weeks and 3 months after application of the tested materials. Patients were informed to rate their perception to tactile, air and cold stimuli by using Verbal Rating Score (VRS) and Visual Analogue Scale (VAS).
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Totally removed smear layer<br>Smear layer is completely removed by etchant of phosphoric acid | Drug: Olinanoseal<br>* it contains nanometer particles of fluoroapatite and calcium fluoride - guarantees the resistance to cracks and abrasion. At the same time insoluble nano-fluoroapatites fill all enamel microcracks and closes open dentinal tubules.<br>* Other names: silicone polymer protector varnish;Drug: Curodont D'senz<br>* This agent contains p 11-4 peptide in addition to fluoride<br>* Other names: Self assembling peptide containing desensitizing agent;|
| Other: Partially removed smear layer<br>Smear layer is partially removed by etchant of phosphoric acid | Drug: Olinanoseal<br>* it contains nanometer particles of fluoroapatite and calcium fluoride - guarantees the resistance to cracks and abrasion. At the same time insoluble nano-fluoroapatites fill all enamel microcracks and closes open dentinal tubules.<br>* Other names: silicone polymer protector varnish;Drug: Curodont D'senz<br>* This agent contains p 11-4 peptide in addition to fluoride<br>* Other names: Self assembling peptide containing desensitizing agent;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| dentin hypersensitivity | pain score (visual analogue scale VAS [minmum =0 {best}, maximum=10 {worst}] and verbal rating scale VRS [minmum =0 {best}, maximum=4 {worst}]) | 2 minutes | 
| dentin hypersensitivity | pain score (visual analogue scale VAS [minmum =0 {best}, maximum=10 {worst}] and verbal rating scale VRS [minmum =0 {best}, maximum=4 {worst}]) | 2 weeks | 
| dentin hypersensitivity | pain score (visual analogue scale VAS [minmum =0 {best}, maximum=10 {worst}]) and verbal rating scale VRS [minmum =0 {best}, maximum=4 {worst}]) | 4 weeks | 
| dentin hypersensitivity | pain score (visual analogue scale VAS [minmum =0 {best}, maximum=10 {worst}] and verbal rating scale VRS [minmum =0 {best}, maximum=4 {worst}]) | 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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OLiNano SEAL, Curodont D'Senz, Dentin Hypersensitivity, Dye penetration, Dentin permeability