Hypnosis for Chronic Idiopathic Pruritus

Study Overview
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Brief Summary
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Chronic idiopathic pruritus (CIP) is a frequent and disabling condition, for which there is no specific treatment. It was shown previously that hypnosis can relieve painful sensations. Pain and pruritus share many similarities regarding sensory receptors and pathways, suggesting that hypnosis might help relief CIP.

Detailed Description
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Chronic idiopathic pruritus (CIP) is a frequent and disabling condition, with significative impact on quality of life. At present, there is no specific treatment for CIP. Topical steroids are frequently used, with partial efficacy, and adverse effects. Hypnosis is a specific state of conscience. It differs from waking state, sleeping state, relaxation, or meditation. In this state, the person is highly responsive to suggestion. In medicine, hypnosis can be used to engage the internal resources of the person against unpleasant feelings. It was shown previously that hypnosis can relieve painful sensations. Pain and pruritus share many similarities regarding sensory receptors and pathways, suggesting that hypnosis might help relief CIP.

Official Title
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A Prospective Study of Hypnosis for Chronic Idiopathic Pruritus

Conditions
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Chronic Idiopathic Pruritus

Intervention / Treatment
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* Other: Hypnosis


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Male or female of at least 18 years at screening Diagnosis of chronic (at least 6 wks.) idiopathic pruritus Pruritus Numeric Rating Scale > = 4 Exclusion Criteria: Pruritus caused by a dermatological or a systemic conditions Suicidal crisis, moderate, or severe Psychosis (schizophrenia, persistent delusional disorder) Bipolar disorder, not stabilized or decompensating Personality disorder, decompensated

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Hypnosis<br>hyspnosis treatment | Other: Hypnosis<br>* Chronic idiopathic pruritus is treated by hypnosis<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change From Baseline in Pruritus Numeric Rating Scale | Assessment of the intensity of pruritis in Pruritus Numeric Rating Scal; the minimum and maximum values 0 to 10 | Day 84 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change From Baseline in Pruritus Verbal Rating Scale | Assessment of Pruritus by pruritus Verbal Rating Scale; the minimum and maximum values 0 to 4 | Day 84 | 
| Change From Baseline in Sleeping Scale | assessment in sleeping scale ; the minimum and maximum values 0 to 10 | Day 84 | 
| Change From Baseline in DLQI scale | assessment in DLQI scale; result between 0 to 30 | Day 84 | 
| Change From Baseline in HAD scale | assessment in HAD scale; result between 0 to 42 | Day 84 | 
| Change From Baseline in usage of topical steroids | assessment in usage of topical steroids | Day 84 | 
| Evaluation of tolerance of hypnosis | assessment of tolerance of hypnosis with report of adverse event | Day 84 |