Transcranial Magnetic Stimulation in Mild Cognitive Impairment and Alzheimer Disease

Study Overview
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Brief Summary
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The investigators reviewed 12 years of clinical use in an outpatient neurology setting of transcranial magnetic stimulation (TMS) in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) to evaluate safety and efficacy of TMS.

Detailed Description
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The investigators compiled demographic, clinical, and neurocognitive data on all patients who had received TMS for any reason in the clinic over a 12-year period. Of 236 patients receiving TMS, 59 patients with AD and 14 with MCI satisfied study criteria and were compared to controls from the National Alzheimer's Coordinating Center (NACC). Neurocognitive outcomes were compared between magnetic resonance imaging (MRI) and electroencephalogram (EEG)-grid guided TMS in patients. Tolerability data was reviewed for all patients.

Official Title
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Transcranial Magnetic Stimulation (TMS) in Patients With Mild Cognitive Impairment (MCI) and Alzheimer Disease (AD): A Twelve-year Retrospective Observational Study

Conditions
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Alzheimer Disease, Mild Cognitive Impairment

Intervention / Treatment
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* Device: Transcranial Magnetic Stimulation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients meeting the National Institute of Neurological and Communicative Disorders and Stroke and Alzheimer's Disease and Related Disorders Association (NINCDS- ADRDA) criteria for possible or probable Alzheimer's disease. Patients meeting the National Institute of Neurological and Communicative Disorders and Stroke and Alzheimer's Disease and Related Disorders Association (NINCDS- ADRDA) criteria for mild cognitive impairment. Patients must have undergone at least two standardized neurocognitive batteries before and after beginning TMS. Patients must have received greater than or equal to five (5) TMS sessions in less than one year. Exclusion Criteria: • Patients with dementias from other causes, such as Lewy Body disease.
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| EEG-grid-guided-TMS<br>Patients with Alzheimer disease and mild cognitive impairment receiving TMS using electroencephalogram grid guided navigation | Device: Transcranial Magnetic Stimulation<br>* Magnetic stimulation to alter neural activity<br>* Other names: TMS;|
| MRI-guided-TMS<br>Patients with Alzheimer disease and mild cognitive impairment receiving TMS using MRI guided navigation | Device: Transcranial Magnetic Stimulation<br>* Magnetic stimulation to alter neural activity<br>* Other names: TMS;|
| NACC controls<br>National Alzheimer's Coordinating Center matched controls | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Controlled Oral Word Association Test | Animal score and percentile | 05/01/2008-05/30/2020 | 
| Boston 30-item naming test | spontaneous correct (without cues) | 05/01/2008-05/30/2020 | 
| Boston 30-item naming test | total correct (with cues) | 05/01/2008-05/30/2020 | 
| Wechsler Adult Intelligence Scale III | Digit span | 05/01/2008-05/30/2020 | 
| Wechsler Adult Intelligence Scale III | verbal quotient score and percentile | 05/01/2008-05/30/2020 | 
| Wechsler Adult Intelligence Scale III | performance quotient score and percentile | 05/01/2008-05/30/2020 | 
| Wechsler Adult Intelligence Scale III | object assembly | 05/01/2008-05/30/2020 | 
| Wechsler Memory Scale III | Immediate memory score and percentile | 05/01/2008-05/30/2020 | 
| Wechsler Memory Scale III | Auditory delayed memory score and percentile | 05/01/2008-05/30/2020 | 
| Wechsler Memory Scale III | Visual delayed memory score and percentile | 05/01/2008-05/30/2020 | 
| Buschke Selective Reminding Test, 12 item | Total recall score | 05/01/2008-05/30/2020 | 
| Buschke Selective Reminding Test, 12 item, 15 minute | Delayed recall score | 05/01/2008-05/30/2020 | 
| Rosen Drawing Test | Total score | 05/01/2008-05/30/2020 | 
| Processing speed | Total score and percentile | 05/01/2008-05/30/2020 | 
| Mini-mental status examination | Total score | 05/01/2008-05/30/2020 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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TMS, Transcranial Magnetic Stimulation