Clinical Trial of Two Study Drinks in Detoxification of Environmental Toxicants and Carcinogens

Study Overview
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Brief Summary
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The goal of this research is to determine if consuming one of two study drinks will help enhance the detoxification of multiple environmental toxicants and cancer causing agents, particularly in subjects who are null for glutathione-S-transferase M1 (GSTM1), glutathione-S-transferase T1 (GSTT1), or both. If our research supports this idea, this drink could be an inexpensive dietary component, which could promote good health.

Official Title
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Clinical Trial of Two Study Drinks in Detoxification of Environmental Toxicants and Carcinogens

Conditions
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Healthy

Intervention / Treatment
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* Dietary Supplement: Freeze dried Powder
* Dietary Supplement: Placebo Preparation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adult Male or female. Participants can be smokers or non-smokers In good physical health In stable and good mental health Not using any medications that may affect the Nrf2 pathway Women who are not pregnant or nursing or planning to become pregnant Participants have provided written informed consent to participate in the study Exclusion Criteria: Significant immune system disorders, respiratory diseases, kidney or liver diseases or any other medical disorders that may affect biomarker data as determined by the licensed medical professional Vital signs outside of the allotted range Not willing to abstain from eating cruciferous vegetables during the course of the study

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Freeze Dried Powder Preparation<br> | Dietary Supplement: Freeze dried Powder<br>* Freeze dried powder containing gluconasturtiin, which when added to a provided juice, will result in a target dose of up to 40 mg/day of 2-phenethyl isothiocyanate (PEITC). Preparation consumed at breakfast, lunch and dinner 3x daily for 2 weeks.<br>Dietary Supplement: Placebo Preparation<br>* Placebo powder added to a provided juice. Preparation consumed at breakfast, lunch and dinner 3x daily for 2 weeks.<br>|
| Placebo Comparator: Placebo<br> | Dietary Supplement: Freeze dried Powder<br>* Freeze dried powder containing gluconasturtiin, which when added to a provided juice, will result in a target dose of up to 40 mg/day of 2-phenethyl isothiocyanate (PEITC). Preparation consumed at breakfast, lunch and dinner 3x daily for 2 weeks.<br>Dietary Supplement: Placebo Preparation<br>* Placebo powder added to a provided juice. Preparation consumed at breakfast, lunch and dinner 3x daily for 2 weeks.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Effect of study drink Preparation on toxins | Prevalence of environment toxins in study population | 2 Months | 
| Effect of study drink Preparation on carcinogens | Prevalence of carcinogens in study population | 2 Months |