Effect of Transversus Abdominis Plane Block Combined With Dexmedetomidine Infusion on the Prognosis in Elderly Patients Undergoing Abdominal Surgery

Study Overview
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Brief Summary
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To compare the prognosis of elderly patients undergoing radical resection of colorectal cancer treated with general anesthesia and general anesthesia combined with transversus abdominis plane block and continuous infusion of dexmedetomidine. The incidence of postoperative delirium, postoperative acute pain moderately to severely and poor postoperative recovery were composite endpoints to determine the prognosis of patients.

Official Title
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Effect of Transversus Abdominis Plane Block Combined With Dexmedetomidine Infusion on the Prognosis in Elderly Patients Undergoing Abdominal Surgery

Conditions
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Colorectal Neoplasms, Aged

Intervention / Treatment
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* Procedure: Transversus abdominis plane block using ropivacaine
* Drug: Dexmedetomidine
* Procedure: Transversus abdominis plane block using saline
* Drug: Saline


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Aged 65-80 years,regardless of gender American Society of Anesthesiologists physical status I-III Undergoing elective radical resection of colorectal cancer Sign informed consent Exclusion Criteria: Could not cooperate to complete the pain VAS evaluation Could not cooperate to complete the cognitive function assessment

Ages Eligible for Study
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Minimum Age: 65 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Dex+TAPB group<br>Patients in Dex+TAPB group will receive the bilateral transversus abdominis plane block with 0.25% ropivacaine 20ml each side before anesthesia and combined with continuous infusion of dexmedetomidine during operation. | Procedure: Transversus abdominis plane block using ropivacaine<br>* Before anesthesia, the ultrasound-guided bilateral transversus abdominis plane block using 0.25% ropivacaine was perdormed by anesthesiologist who is not involved in intraoperative management and postoperative follow-up and evaluate the effect after the block completed.<br>Drug: Dexmedetomidine<br>* After finished the transversus abdominis plane block, then perform tracheal intubation and start the infusion of dexmedetomidine.<br>|
| Placebo Comparator: Control group<br>Patients in control group will receive the bilateral transversus abdominis plane block with saline 20ml each side before anesthesia and don't receive the infusion of dexmedetomidine during operation. | Procedure: Transversus abdominis plane block using saline<br>* Before anesthesia, the ultrasound-guided bilateral transversus abdominis plane block using saline was perdormed by anesthesiologist who is not involved in intraoperative management and postoperative follow-up and evaluate the effect after the block completed.<br>Drug: Saline<br>* After finished the transversus abdominis plane block, then perform tracheal intubation and start the infusion of saline, dosage and infusion method of saline are consistent with dexmedetomidine.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The prognosis of aged patients | The incidence of postoperative delirium, postoperative acute pain moderately to severely and poor postoperative recovery were composite endpoints to determine the prognosis of patients. | Postoperative 72 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Delirium, Pain, Postoperative, Dexmedetomidine, Transversus abdominis plane block