Loco-regional Complications of Pharyngitis in Children: a National Case-Control Study

Study Overview
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Brief Summary
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To study the association between several exposures of interest and the occurrence of infectious loco-regional complications of pharyngitis in children.

Detailed Description
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Investigators will include in the study (after agreement of child and parents): Cases: children < 18 years old hospitalized for peripharyngeal suppurations, diffuse cervical cellulitis or cervical adenophlegmon in participating Ear, Nose & Throat (ENT) and pediatric departments. Controls: children < 18 years old with pharyngitis but without infectious complications recruited by general practitioners (GPs) or by primary care pediatricians in private setting, matched to cases by age, date of infectious complication (index date), delay between the pharyngitis and the index date and, if possible, the referring physician. Primary endpoint: Difference in the frequency of exposure to various factors among cases and controls during an exposure window going from the date of diagnosis of pharyngitis to day -0.5 of the index date of the complication. Several exposure of interest will be compared between cases and controls. One specific main exposure of interest during a predefined window of exposure has been defined but will not be revealed to investigators to avoid selection bias. Several secondary exposure of interest were a priori defined but will not be revealed to investigators to avoid selection bias.

Official Title
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Loco-regional Complications of Pharyngitis in Children: a National Case-Control Study

Conditions
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Pharyngitis

Intervention / Treatment
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* Other: Collection of data
* Other: No collection of data


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Cases: children < 18 years old hospitalized for peripharyngeal suppurations, diffuse cervical cellulitis or cervical adenophlegmon in participating Ear, Nose & Throat (ENT) and pediatric departments. Controls: children < 18 years old with pharyngitis but without infectious complications recruited by general practitioners (GPs) or by primary care pediatricians in private setting, matched to cases by age, date of infectious complication (index date), delay between the pharyngitis and the index date and, if possible, the referring physician. Exclusion Criteria: Children (cases or controls) with chronic renal failure, hemophilia, chronic thrombocytopenia or immunosuppression (constitutional or iatrogenic) at the time of pharyngitis

Ages Eligible for Study
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Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cases<br>Cases: children with loco-regional complications of pharyngitis | Other: Collection of data<br>* Collection of data on clinical, bacteriological and computed tomography data concerning the case, which will be needed by the adjudication committee and for defining the index date.<br>|
| Controls<br>Controls: children with pharyngitis but without infectious complications | Other: No collection of data<br>* The interviewer will note sociodemographic characteristics (age, weight, sex), symptoms and their evolution, and all drug intakes of the patient during the month before the index date.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Frequency of exposure of interest |  | from the date of diagnosis of pharyngitis up to 6 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Magnitude of the exposure of interest |  | from the date of diagnosis of pharyngitis up to 6 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Pharyngitis, case-control study, loco-regional complications of pharyngitis