Neuromuscular and Cognitive Fatigue During a 24 Hour Treadmill Running Exercise

Study Overview
=================
Brief Summary
-----------------
The main purpose of the present study is to determine the relative contributions of central and peripheral fatigue during an ultra-endurance exercise.

Detailed Description
-----------------
For that purpose, 14 subjects running 24 hours on a treadmill will be compared with a control group being awake during the same period. Subjects who running will have electrically evoked forces on the muscles associated EMG activity, blood samples and muscle biopsy.

Official Title
-----------------
Neuromuscular and Cognitive Fatigue During a 24h Treadmill Running Exercise.

Conditions
-----------------
Healthy

Intervention / Treatment
-----------------
* Procedure: running during 24 hours without sleep
* Other: no sleeping


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: The subjects of the experimental group will be recruited among experienced ultra-runners . They all have run at least a 12 hour race or longer. The control group will be recruited among experienced ultra-runners . Age of control group will be age experimental group more or less 2 years. Exclusion Criteria: The subjects will not be selected if: they were injured in the 3 months before the experiment they had a tendon or joint pathology that could impair strength measurements. they participate to an other experiment at the same time

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>patients running during 24 hours without sleep | Procedure: running during 24 hours without sleep<br>* patients running during 24 hours without sleep<br>|
| Placebo Comparator: 2<br>patients without sleep during 24 hours | Other: no sleeping<br>* patients without sleep during 24 hours<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| -Voluntary and electrically evoked forces on the contracted muscles |  | 24 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Electrically evoked forces on the relaxed muscles and associated EMG activity |  | 24 hours | 
| Blood samples before the exercise |  | every 4 hours | 
| Muscle biopsy (vastus lateralis) |  | before and after the exercise | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Running during 24 hours, Voluntary evoked force on the muscles, Electrically evoked force on the muscles, EMG activity, Muscle biopsy, subjects will be recruited among experienced ultra-runners