Assessment of Autogenous Dentin Graft in Treatment of Infra-bony Defect

Study Overview
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Brief Summary
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The aim of the present study was to evaluate the effect of demineralized autogenous dentine on treatment of infrabony defects.

Detailed Description
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In this study, the investigators tested the effect of demineralized autogenous dentine as a bone graft in treatment of stage III periodontitis in term of probing pocket depth reduction, mean gain in clinical attachment level, and bone gain in defect sites.

Official Title
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Clinical and Radiographic Assessment of Autogenous Dentin Nanoparticles in Treatment of Stage III Periodontitis: A Split-Mouth Clinical Study

Conditions
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Periodontitis (Stage 3)

Intervention / Treatment
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* Procedure: Autogenous demineralized dentin nanoparticles


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with good systemic health and no contraindication for periodontal surgery. Patients who are able to maintain good oral hygiene. Gingival thickness for the site selected should be ≥1mm. Probing depth of ≥ 6mm. Patient has at least one hopeless teeth Exclusion Criteria: Active infectious diseases (hepatitis, tubercu¬losis, HIV, etc….). Medically compromised patients. Smokers and alcoholic abusers People who suffer from any systemic disease that affect the periodontium. Pregnant, postmenopausal women. People who take anti-inflammatory drugs, anti¬biotics or vitamins within the previous 3 month. People who use mouth washes regularly Participants in other clinical trials.

Ages Eligible for Study
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Minimum Age: 16 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Open flap debridement + allograft bone (Maxgraft)<br> | Procedure: Autogenous demineralized dentin nanoparticles<br>* Effect of Autogenous demineralized dentin nanoparticles in bone gain in infrabony defect<br>|
| Active Comparator: Open flap debridement + Autogenous demineralized nanoparticles<br> | Procedure: Autogenous demineralized dentin nanoparticles<br>* Effect of Autogenous demineralized dentin nanoparticles in bone gain in infrabony defect<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Vertical bone loss | vertical bone loss was measured from cementoenamel junction (CEJ) to the base of the bone defect in each site in group I & II. | 6 months | 
| Clinical attachment level | Clinical attachment level was measured at baseline and 6 months | 6 months | 
| Probing pocket depth | Probing pocket depth was measured at baseline and 6 months | 6 months | 
| Bone gain | The bone gain is calculated by: Preoperative VBL (at baseline): measured as the distance from cementoenamel junction (CEJ) to the base of the bone defect. Postoperative VBL (after 6 months) measured as the distance from cementoenamel junction (CEJ) to the base of the bone formation. Postoperative bone fill (bone gain after 6 months) [measured by subtracting the preoperative VBL from the postoperative VBL]. | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Plaque Index | plaque index was measured at baseline, 3, 6 months | 6 months | 
| Gingival index | Gingival index was measured at baseline, 3, 6 months | 6 months |