Use of Infrared Spectroscopy in Fast Septic Arthritis Diagnosis

Study Overview
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Brief Summary
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To study the diagnostic performance of infrared spectroscopy on fresh synovial fluids in early septic arthritis diagnosis in patients with acute joint effusion

Detailed Description
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Diagnosis of a joint effusion is frequently a medical emergency, especially when septic arthritis is suspected. Septic arthritis diagnosis relies on microscopic and bacteriological analysis of synovial fluid obtained by arthrocentesis. Direct microscopic examination can be made within 2 to 12 hours but it is negative in about 50 % of the cases. It is necessary to wait 72 hours to obtain the result of the culture and reasonably rule out the diagnosis of septic arthritis. A method of establishing an immediate etiological diagnosis could improve the care of patients with joint effusion that is a therapeutic emergency and justify a hospitalization and a parenteral antibiotic therapy.

Official Title
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Use of Infrared Spectroscopy in Fast Septic Arthritis Diagnosis

Conditions
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Joint Effusion

Intervention / Treatment
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* Device: Infrared spectroscopy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients over 18 year old patients with an acute arthritis defined by an evolution of less than 6 weeks patients benefiting from joint fluid puncture for diagnostic purposes in the rheumatology hospitals participating in the study patients who received information about the protocol and have not expressed opposition to participate Exclusion Criteria: patients opposing the study protected major (safeguard justice, trusteeship and guardianship) and persons deprived of liberty

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: Infrared spectroscopy|Infrared spectroscopy|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diagnosis of the cause of joint effusion | The final diagnosis of the cause of joint effusion is made by the clinician based on the clinical and laboratory data : septic arthritis or other causes of arthritis | Up to 7 days (time to perform Spectroscopy and collect laboratory results) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of days of hospitalization | The clinician will be asked to state how a positive or a negative result of the diagnostic test under study would have affected his decision to hospitalize the patient | Up to 2 months (time to collect data on hospitalization duration and antibiotic therapy duration) | 
| Total dose of antibiotics | The clinician will be asked to state how a positive or a negative result of the diagnostic test under study would have affected his decision to start antibiotic therapy | Up to 2 months (time to collect data on hospitalization duration and antibiotic therapy duration) |