Effects of Sodium Bicarbonate Supplementation on Intermittent and Intense Task

Study Overview
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Brief Summary
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The aim of this study was to verify if sodium bicarbonate (NaHCO3) suplementation promotes changes in the performance, muscular activity and strength of individuals trained during the intermittent and intense task . Twelve trained adult men will participate in this randomized, double-blind, crossover clinical trial. Each participant should receive two types of intervention with a 14-day interval between conditions: alkalosis (ALK) in which gelatinous capsules containing 0.3 g.kg -1 of NaHCO 3 and placebo (PLA) are administered, in which 0.3 g.kg-1 of Calcium Carbonate (CaCO3). The following results will be considered: electromyographic activity (EMG) of the quadriceps muscle, peak torque, pH, lactate, and perception of effort, recovery and pain questionnaires, which will be collected during intermittent and high intensity DI protocol. ANOVA of repeated measures will be used to verify possible differences between groups.

Official Title
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Sodium Bicarbonate Supplementation Promotes Changes in Performance, Muscle Activity and Strength of Individuals Trained During the Performance of Intermittent and Intense Task? Randomized, Double-blind, Crossover Trial

Conditions
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Sodium Bicarbonate, Alkalosis, Metabolic, Electromyography, Fatigue

Intervention / Treatment
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* Dietary Supplement: Sodium bicarbonate
* Dietary Supplement: Calcium carbonate


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: resistance trained men (minimum 12 moths resistance training experience) Exclusion Criteria: diabetes mellitus; respiratory (asthma, COPD), renal, metabolic, rheumatic and cardiovascular disorders; acid-base balance disorder; continuous use of some type of medication; use of high-protein supplementation and creatine supplementation; users of anabolic steroids.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 42 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Alkalosis group<br>The subjects should receive gelatinous capsules containing 0.3 g.kg -1 of sodium bicarbonate | Dietary Supplement: Sodium bicarbonate<br>* The subjects should ingest 0.3g.kg of sodium bicarbonate 90 minutes before the beginning of the protocol task.<br>|
| Placebo Comparator: Placebo group<br>The subjects should receive gelatinous capsules containing 0.3 g.kg -1 of Calcium Carbonate | Dietary Supplement: Calcium carbonate<br>* The subjects should receive gelatinous capsules containing 0.3 g.kg -1 of Calcium Carbonate<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Electromyographic activity of the femoral quadriceps evaluated with electromyography equipment | The electromyographic activity will be obtained during the execution of 10 series composed of ten repetitions of extension (concentric phase) and flexion (eccentric phase) of the knee joint, at an angular velocity of 120os-1 (radians per second), with interval of 1 minute interval between sets in an isokinetic dynamometer. | 60 minutes | 
| Peak torque assessed with isokinetic dynamometer equipment | The peak torque will be obtained during the execution of 10 series composed of ten repetitions of extension (concentric phase) and flexion (eccentric phase) of the knee joint, at an angular velocity of 120os-1 (radians per second), with interval of 1 minute interval between sets. | 60 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Lactate assessed with portable lactometer | The lactate quantification will be performed before and after the test session characterized by the execution of 10 series composed of ten repetitions of extension (concentric phase) and flexion (eccentric phase) of the knee joint, at an angular velocity of 120os-1 (radians per second), with an interval of 1 minute between sets in an isokinetic dynamometer. | 15 seconds |