The Lipid Profile of the Skin Surface in Acne

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate the differences in the skin lipid profile of patients with and without acne. Secondly, the goal is to learn more about what the effects of retinoinds (topical and systemic) are on the the skin lipid profile. We hypothesize that the skin lipid profile of subjects with acne will be lower in inflammatory lipids in comparison to subjects without acne.

Detailed Description
-----------------
Skin lipid profile will be conducted via sebutapes- adhesive tapes that painlessly absorbs sebum from the face. These tapes will be placed on the face for 1 hour. A photograph of the face will be taken during each study visit. A sebumeter will also be used to measure skin sebum secretion rate.

Official Title
-----------------
The Lipid Profile of the Skin Surface in Acne

Conditions
-----------------
Acne

Intervention / Treatment
-----------------
* Drug: Tretinoin or Adapalene
* Drug: Isotretinoin


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age 12 to 30 years have been prescribed tretinoin OR isotretinoin Exclusion Criteria: those who have taken isotretinoin (systemic) those who used tretinoin or other topical retinoid within two weeks of starting the study those with seborrheic dermatitis, rosacea, or polycystic ovary syndrome those who are pregnant, prisoners, or cognitively impaired those who do not fit the inclusion criteria

Ages Eligible for Study
-----------------
Minimum Age: 12 Years
Maximum Age: 30 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Healthy Group<br>The subjects in this group do not have a history of acne. | |
| Acne Group, Topical Retinoid<br>These subjects have been prescribed a topical retinoid for their acne. They will participate in the study for a period of 1 month. | Drug: Tretinoin or Adapalene<br>* Subjects will apply a pea sized amount of topical retinoid cream once daily at night for 30 days. Subjects will return for a follow-up visit.<br>* Other names: Retin A;|
| Acne Group, Isotretinoin<br>These subjects have been prescribed isotretinoin for their acne. They will participate in the study for a period of 5-6 months. | Drug: Isotretinoin<br>* Subjects will take one pill once daily for 5 months. Subjects will return after 1 month and after 4-5 months of treatment for skin lipid profiling.<br>* Other names: Accutane;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Skin lipid profile of acne and healthy patients | Compare the skin lipid profile of acne and healthy patients at baseline | baseline visit | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Skin lipid profile of acne patients after treatment | Patients in the topical retinoid group will have their lipids evaluated after 1 month of treatment. Patients in the systemic retinoid (isotretinoin) group will have their lipids evaluated after 1 and 4-5 months of treatment. | at 1 month and 4-5 months of treatment | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
acne, lipid, tretinoin, isotretinoin