Interpretation Bias Modification for Body Dysmorphic Disorder

Study Overview
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Brief Summary
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The purpose of this study is to determine whether a computerized intervention designed to reduce appearance and evaluation related interpretation biases will reduce symptoms associated with body dysmorphic disorder.

Detailed Description
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The present study aims to examine the feasibility of a remote treatment for body dysmorphic disorder delivered via the Internet. To evaluate the efficacy of the IBM protocol we have developed in reducing negative appearance and evaluative related interpretations, we will conduct a two-arm randomized controlled trial over the internet. Individuals with a diagnosis of body dysmorphic disorder (N = 40) will be randomized to one of two conditions: 1) IBM or 2) progressive muscle relaxation. Each condition will consist of eight 10-25 minute treatment sessions. Participants will complete two sessions per week for four weeks and will be administered assessments at pre-treatment, one week post-treatment and at 3-month follow-up. We hypothesize that: 1) IBM will lead to greater reductions in BDD symptoms than the PMR condition; 2) IBM will lead to greater reductions in depression, anxiety and suicidal ideation than the PMR condition; 3) IBM will lead to greater reductions in threat interpretations and greater increases in benign interpretations than the PMR condition; 4) The effects of condition on BDD symptoms will be mediated by changes in BDD-related interpretation bias; and 5) The effects of training in the IBM condition will be maintained at the 3-month follow-up assessments.

Official Title
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Evaluation of an Internet-Based Treatment for Body Dysmorphic Disorder

Conditions
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Body Dysmorphic Disorder

Intervention / Treatment
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* Behavioral: Interpretation Bias Modification
* Behavioral: Progressive Muscle Relaxation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Current diagnosis of Body Dysmorphic Disorder according to DSM-5 criteria BDD-YBOCS score greater than or equal to 20 Fluent in English No significant physical defect or flaw in appearance (e.g., disfiguration) Exclusion Criteria: History of psychotic disorder, bipolar disorder, borderline personality disorder Current substance use disorder Unstable medication status (i.e. change in medication within the last month) Concurrent psychotherapy for appearance concerns Active and clinically significant suicidality

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Interpretation Bias Modification (IBM)<br>Treatment consists of eight brief sessions. In Task 1, participants read unique scenarios (You notice someone pointing in your direction). A sentence meant to resolve the ambiguity will appear (This person thinks they reco_nize you). After filling in the missing letter, the interpretation is reinforced by requiring the participants to correctly answer yes or no to a comprehension question (Is this person mocking you?). In Task 2, participants are shown a word denoting a threatening (mocking) or benign (cheerful) interpretation. Participants are presented with an ambiguous scenario (You hear people at a nearby table laughing) and asked to denote whether the word and the sentence are related. Participants will receive positive or negative feedback based on their response. | Behavioral: Interpretation Bias Modification<br>* Eight 10-25 minute sessions of interpretation modification to reduce negative interpretation biases related to appearance.<br>|
| Active Comparator: Progressive Muscle Relaxation (PMR)<br>Participants will receive eight brief sessions of PMR. They will listen to a PMR script (Kassinove & Tafrate, 2002). Participants will be asked to make sure they are sitting comfortably, close their eyes, and systematically tense and release 10 different muscle groups. | Behavioral: Progressive Muscle Relaxation<br>* Eight 15-minute sessions of progressive muscle relaxation (PMR).<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Yale-Brown Obsessive Compulsive Scale Modified for Body Dysmorphic Disorder (BDD-YBOCS; Phillips et al., 1997) | Measures past-week BDD symptom severity | change from baseline at one-week post treatment and 3-months post-treatment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Beck Depression Inventory (BDI-II; Beck, Steer, & Brown, 1996) | Measures depressive symptom severity | change from baseline at one-week post treatment and 3-months post-treatment | 
| Beck Anxiety Inventory (BAI; Steer & Beck, 1997) | Measure anxious symptom severity | change from baseline at one-week post treatment and 3-months post-treatment | 
| Depressive Symptom Index-Suicidality Subscale | Measure severity of recent suicidality | change from baseline at one-week post treatment and 3-months post-treatment | 
| Body Dysmorphic Disorder Word Sentence Association Paradigm (BDD-WSAP; modified from Hindash & Amir, 2011) | Measure of strength of BDD-related (i.e. evaluation- and appearance- related threat interpretation biases) | change from baseline at one-week post treatment and 3-months post-treatment |