Magnetic Resonance Imaging Study of Cognitive-Behavior Therapy for Major Depressive Disorder

Study Overview
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Brief Summary
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Study hypothesis: psychotherapy and SSRI treatment effect in different brain way: psychotherapy in up to down way and SSRI in down to up way. The investigators will explore this hypothesis in major depressive disorder outpatients with Magnetic Resonance Imaging analysis in this study. Patients in different groups will be treated by psychotherapy or SSRI treatment. They will all be checked with Magnetic Resonance Imaging pro and after 12 weeks of treatment.

Detailed Description
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Patients meeting the inclusion criteria undergo an examination that included a diagnostic interview, vision test, and psychophysiological measures. Participants then undergo the baseline fMRI scan within 48 hours, after that, they will receive psychotherapy or SSRI treatment.and returned the scan once they completed the therapy.

Official Title
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Magnetic Resonance Imaging Study of Cognitive-Behavior Therapy for Major Depressive Disorder

Conditions
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Major Depressive Disorder

Intervention / Treatment
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* Drug: SSRI antidepressants
* Behavioral: Cognitive-Behavior Therapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: meet SCID -Ⅰ/P major depressive disorder diagnosis; Right handedness; good visual acuity. Exclusion Criteria: neurological disease ; serious physical illness (e.g. heart, lung, liver, kidney or blood system disease); with other mental disorder; psychotic symptoms personality disorders; pregnancy; suicidal risk; treatment by antidepressants or other psychotropic medications within 6 months prior to the start of the trial; with contraindication for MRI

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Cognitive-Behavior Therapy group<br>treatment with Cognitive-Behavior Therapy | Behavioral: Cognitive-Behavior Therapy<br>* The essence of CBT is a learning process through which an appropriate pattern in cognitive and behavioral could be learn and stored as memory<br>* Other names: cognitive behavioural therapy（CBT）;|
| Active Comparator: SSRI antidepressants<br>treatment by SSRI antidepressant | Drug: SSRI antidepressants<br>* SSRI antidepressants are Selective serotonin reuptake inhibitors. They include fluoxetine (Prozac); sertraline (Zoloft); paroxetine (Paxil); citalopram (Celexa) ;escitalopram (Lexapro) and fluvoxamine (Luvox). It will be chosen according to special condition of every patient.<br>* Other names: fluvoxamine (Luvox);|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hamilton Rating Scale for Depression (HAMD) | The 24-item version of the Hamilton Rating Scale for Depression (HAMD; Hamilton, 1960) will be used for measuring severity of depressive symptoms. Minimum and maximum possible values are respectively 0 and 78. Lower scores show more mild depression. | an expected average of 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Magnetic Resonance Imaging |  | an expected average of 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cognitive-Behavior Therapy, Magnetic Resonance Imaging, major depressive disorder