Relationship Between Normal-weight Central Obesity and Obstructive Sleep Apnea

Study Overview
=================
Brief Summary
-----------------
Comparison of the prevalence of obstructive sleep apnea (OSA), measured by polysomnography in normal weight patients with central obesity by body mass index (BMI) and waist hip ratio (WHR), with normal weight patients without central obesity by BMI and WHR. Evaluation of arterial stiffness and vascular age in normal weight patients with central obesity and in normal weight patients without central obesity. Determination of the exercise response characteristics in OSA patients.

Detailed Description
-----------------
Body composition (the distribution of adipose tissue) appears to be a risk factor for the prevalence of obstructive form of sleep apnea. The investigators expect a higher prevalence of this serious sleep pathology in normal weight patients with central obesity than in normal weight patient without central obesity. In normal weight patients with central obesity also endothelial dysfunctions, abnormal exercise response to dynamic load and abnormal circadian patterns of blood pressure and heart rate can be expected. There are theoretical assumptions for this hypothesis but relevant studies on sufficiently large samples of patients have not been done. The investigators will also compare the lipid profile in normal weight patients with central obesity with those of normal weight patients without central obesity.

Official Title
-----------------
Relationship Between Normal-weight Central Obesity and Obstructive Sleep Apnea. The Role of Body Fat Distribution in the Prevalence of Obstructive Sleep Apnea.

Conditions
-----------------
Sleep Disorder, Body Fat Distribution

Intervention / Treatment
-----------------
* Device: Overnight polysomnography


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria central obesity group: BMI 18.5 - 24.9 kg/m2 for both men and women WHR more than 0.9 for men and 0.85 for women no history of myocardial infarction, stroke, atrial fibrillation, previous diagnosis of OSA or its treatment. Inclusion Criteria without central obesity group: BMI 18.5 - 24.9 kg/m2 for men and women WHR selected from the lowest tertile of WHR distribution for both men and women Exclusion Criteria: acute infection known diagnosis of chronic renal or cardiac failure taking drugs that affect sleep (stimulants, hypnotics, antidepressants, antipsychotics, anxiolytics, antihistamines, corticosteroids, theophylline, anti-parkinsonic drugs, anticonvulsants, morphine-type analgetics)

Ages Eligible for Study
-----------------
Minimum Age: 25 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Central obesity group<br>Normal weight central obesity patients (by BMI and WHR). | Device: Overnight polysomnography<br>* Overnight polysomnography will be performed in a sleep laboratory (EEG, EOG, EMG, ECG, respiratory movements of the chest and abdomen, oro-nasal airflow, and O2 saturation will be examined<br>|
| Without central obesity group<br>Normal weight patients without central obesity (by BMI and WHR). | Device: Overnight polysomnography<br>* Overnight polysomnography will be performed in a sleep laboratory (EEG, EOG, EMG, ECG, respiratory movements of the chest and abdomen, oro-nasal airflow, and O2 saturation will be examined<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Apnea hypopnea index | Apnea hypopnea index will be measured in both groups | Through study completion, an average of 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cardio Ankle Vascular Index (CAVI) | Noninvasive arterial stiffness and vascular age index CAVI will be measured in both groups | Through study completion, an average of 1 year | 
| Response on ergo-spirometry test | Cardiopulmonary exercise test parameters (oxygen consumption at peak exercise (ml/kg/min) and VE/VCO2 slope) will be measured in both groups. | Through study completion, an average of 1 year | 
| Ambulatory 24-hour blood pressure measurement (ABPM) | Ambulatory 24-hour blood pressure measurement (ABPM) will be analyzed conventionally and chronobiologically in both broups | Through study completion, an average of 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
obstructive sleep apnea, normal weight obesity