Cigarette and E-cigarette Flavors Manipulations in the Experimental Tobacco Marketplace

Study Overview
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Brief Summary
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This is a one-session study that participants complete remotely including consent, Experimental Tobacco Marketplace purchases, and assessments to examine the effects of cigarette and e-cigarette flavors on cigarette demand and substitution in the Experimental Tobacco Marketplace.

Detailed Description
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This study uses a mixed design (within-subject repeated measures and between-group). Participants will be assigned to two different groups according to their preferred cigarette flavor (tobacco/menthol). Every participant will complete behavioral tasks and make hypothetical purchases of tobacco products in an online store under four different scenarios: a) e-cigarette flavor restricted and cigarette flavor restricted, b) e-cigarette flavor unrestricted and cigarette flavor restricted, c) e-cigarette flavor restricted and cigarette flavor unrestricted, d) e-cigarette flavor unrestricted and cigarette flavor unrestricted.

Official Title
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COMET Study 2: Effects of Cigarette and E-cigarette Flavor Restrictions on Cigarette Demand and Substitution in the Experimental Tobacco Marketplace

Conditions
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Tobacco Use Disorder

Intervention / Treatment
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* Behavioral: Cigarette flavor restricted and e-cigarette flavor restricted
* Behavioral: Cigarette flavor restricted and e-cigarette flavor unrestricted
* Behavioral: Cigarette flavor unrestricted and e-cigarette flavor restricted
* Behavioral: Cigarette flavor unrestricted and e-cigarette flavor unrestricted


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: currently smoke at least 10 cigarettes per day have smoked at least 100 cigarettes (lifetime), and are 21 years of age or older. Exclusion Criteria: inaccurate identification of usual brand of cigarette's as menthol or non-menthol

Ages Eligible for Study
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Minimum Age: 21 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Interventional Model Description: Participants will complete different purchasing scenarios in the Experimental Tobacco Marketplace in which different cigarette and e-cigarette flavors are available. In all scenarios, a range of other tobacco products will also be available.
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Menthol cigarette smokers<br>Adults (21 y.o. and older) who smoke ate least 10 menthol cigarettes per day will be recruited. | Behavioral: Cigarette flavor restricted and e-cigarette flavor restricted<br>* Tobacco cigarettes will be available in the Experimental Tobacco Marketplace Tobacco-flavored e-cigarettes will be available in the Experimental Tobacco Marketplace<br>Behavioral: Cigarette flavor restricted and e-cigarette flavor unrestricted<br>* Tobacco cigarettes will be available in the Experimental Tobacco Marketplace Tobacco-flavored and a range of flavored e-cigarettes will be available in the Experimental Tobacco Marketplace<br>Behavioral: Cigarette flavor unrestricted and e-cigarette flavor restricted<br>* Tobacco and menthol cigarettes will be available in the Experimental Tobacco Marketplace Tobacco-flavored e-cigarettes will be available in the Experimental Tobacco Marketplace<br>Behavioral: Cigarette flavor unrestricted and e-cigarette flavor unrestricted<br>* Tobacco and menthol cigarettes will be available in the Experimental Tobacco Marketplace Tobacco-flavored and a range of flavored e-cigarettes will be available in the Experimental Tobacco Marketplace<br>|
| Experimental: Non-menthol cigarette smokers<br>Adults (21 y.o. and older) who smoke ate least 10 non-menthol cigarettes per day will be recruited. | Behavioral: Cigarette flavor restricted and e-cigarette flavor restricted<br>* Tobacco cigarettes will be available in the Experimental Tobacco Marketplace Tobacco-flavored e-cigarettes will be available in the Experimental Tobacco Marketplace<br>Behavioral: Cigarette flavor restricted and e-cigarette flavor unrestricted<br>* Tobacco cigarettes will be available in the Experimental Tobacco Marketplace Tobacco-flavored and a range of flavored e-cigarettes will be available in the Experimental Tobacco Marketplace<br>Behavioral: Cigarette flavor unrestricted and e-cigarette flavor restricted<br>* Tobacco and menthol cigarettes will be available in the Experimental Tobacco Marketplace Tobacco-flavored e-cigarettes will be available in the Experimental Tobacco Marketplace<br>Behavioral: Cigarette flavor unrestricted and e-cigarette flavor unrestricted<br>* Tobacco and menthol cigarettes will be available in the Experimental Tobacco Marketplace Tobacco-flavored and a range of flavored e-cigarettes will be available in the Experimental Tobacco Marketplace<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| E-cigarette substitution | Participants will complete purchasing trials in an Experimental Tobacco Marketplace (ETM) with cigarettes increasing in price. Product availability in the ETM depended on the experimental condition. The degree to which e-cigarettes substitute for conventional cigarettes as a function of cigarettes and e-cigarettes restriction will be assessed. To obtain estimates of substitution of price-constant products in the different ETM conditions, the investigators will use ordinary least squares regression to model the relationship of the price-manipulated product to predict total quantity purchased of the price-constant product. | 1 day | 
| Cigarette demand | Participants will complete purchasing trials in an Experimental Tobacco Marketplace (ETM) with cigarettes increasing in price. Product availability in the ETM depended on the experimental condition. The degree to which cigarette and e-cigarette restrictions influence demand for conventional cigarettes will be assessed. To obtain dependent measures of demand, participants' purchasing of the price-manipulated commodity in the ETM task will be fit to a modified exponential equation to quantify the relationship between the price of each commodity and purchasing: Q=Q0*10k(exp(-αQ0C)-1) where Q is purchasing of the commodity, C is the price, Q0 is the derived initial purchasing without cost constraints (demand intensity), k is the span of the function in logarithmic units, and α is the demand elasticity. | 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cigarette, E-cigarette, Behavioral Economics, Tobacco Control