linjc16/ctgov huggingface dataset:
Amyotrophic Lateral Sclerosis Web Based Patient Care Database: ALSConnection.Org

Study Overview
=================
Brief Summary
-----------------
The purpose is to collect data for ALS research. The data will be used to learn more about the origin of ALS and to improve quality of care for people with ALS. The information you provide in the ALS registry will be used to evaluate variations in patient care, adherence to standards of care and also to help foster ALS research.

Detailed Description
-----------------
Any person who has been diagnosed with ALS by a physician can enroll into this registry. The information you provide in the ALS registry will be used to evaluate variations in patient care, adherence to standards of care and also to help foster ALS research. An additional focus of this website will be to educate participating patients and visitors to this site about ongoing ALS research.

Official Title
-----------------
Amyotrophic Lateral Sclerosis Web Based Patient Care Database

Conditions
-----------------
Amyotrophic Lateral Sclerosis

Intervention / Treatment
-----------------
* Behavioral: ALS Registry


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: There are no inclusion and exclusion criteria beyond the fact that a person needs to have ALS in order to enroll.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: ALS Registry|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Amyotrophic Lateral Sclerosis
Screening for Obstructive Sleep Apnea Among Members of an Internet Weight Loss Community

Study Overview
=================
Brief Summary
-----------------
The current study was a pilot, double blind, randomized controlled trial to (1) evaluate the feasibility of an online obstructive sleep apnea (OSA) screening intervention, (2) estimate effect size for planning of future studies, and (3) test the hypothesis that the intervention, compared to a control condition, would lead more individuals to discuss OSA with their healthcare provider.

Official Title
-----------------
Effect of a Web-Based Presentation on Communication With Healthcare Providers

Conditions
-----------------
Obstructive Sleep Apnea

Intervention / Treatment
-----------------
* Behavioral: Obstructive sleep apnea screening intervention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Member of SparkPeople.com community and logged on within previous month Live in the US Exclusion Criteria: Prior diagnosis of OSA Prior discussions with healthcare provider about OSA

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Screening
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Intervention<br>Brief, theory-based, online assessment of OSA risk followed by risk-tailed OSA presentation. | Behavioral: Obstructive sleep apnea screening intervention<br>* Brief, theory-based, online assessment of OSA risk followed by risk-tailed OSA presentation.<br>|
| No Intervention: Control<br>No risk assessment or presentation | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Online questionnaire asking whether subject has discussed OSA with healthcare provider since enrolling in study |  | 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Online questionnaire asking whether subject has plans to discuss OSA with healthcare provider, if not done already |  | 12 weeks | 
| Online questionnaire asking whether subject has undergone testing and treatment for OSA since enrolling in study |  | 12 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Obstructive sleep apnea, Internet, Screening, Health belief model
Mp-MRI in the Diagnosis of Liver Fibrosis After Liver Transplantation

Study Overview
=================
Brief Summary
-----------------
It is an open label observation clinical trial, all participants are liver transplant patients. The investigators deem to make a better criteria for assessing liver fibrosis after liver transplantation. The point of the clinical trial is to evaluate the efficacy of multiparameter MRI in the diagnosis of liver fibrosis after liver transplantation.

Detailed Description
-----------------
We collected patients aged 18 to 85 who had undergone liver transplantation. At the same time, all patients underwent liver biopsy or ultrasonic transient elastography after MRI. People who were allergic to gadolinium contrast agent, serious cardiopulmonary disease and contraindications to MRI were excluded.

Official Title
-----------------
Mp-MRI in the Diagnosis of Liver Fibrosis After Liver Transplantation

Conditions
-----------------
Liver Fibrosis After Liver Transplantation, Multiparameter Magnetic Resonance Imaging

Intervention / Treatment
-----------------
* Diagnostic Test: Gadopentetate Dimeglumine Injection


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Subjects aged 18 -85 years Patients after liver transplantation Patients who are going to undergo liver biopsy or ultrasonic transient elastography Patients voluntarily joined the study and signed informed consent Exclusion Criteria: Patients with tumor Patients who are allergic to gadolinium contrast agent Patients with contraindications to magnetic resonance imaging Patients with severe heart and lung diseases Patients who are not suitable for this study according to the researcher's judgment.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: Gadopentetate Dimeglumine Injection|Patients with liver fibrosis after liver transplantation receive multi-parameter magnetic resonance scanning, percutaneous liver biopsy (or FibroScan).|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mp-MRI in the Diagnosis of Liver Fibrosis After Liver Transplantation | Mp-MRI as a PET-CT biomarker to Liver Fibrosis after Liver Transplantation | 03.18.2022 to12.01.2022 |
BC Women's Hospital Noise Pilot

Study Overview
=================
Brief Summary
-----------------
The effect of noise is often underestimated but it is one of the most common occupational health hazards. Its health effects include; noise-induced hearing loss, sleep disturbance, interference with speech comprehension, complaints, stress, annoyance, and safety concerns with regard to workers being able to complete their tasks in a safe manner. This pilot aims to measure and analyze noise levels in obstetric ORs at BC Women's Hospital during elective and emergency cesarean deliveries.

Detailed Description
-----------------
This is a pilot study that aims to measure and analyze noise levels in obstetric ORs at BC Women's Hospital during elective and emergency cesarean deliveries. The investigators want to quantify the amount of noise in BCW ORs in order to create a research question for a larger study.

Official Title
-----------------
Assessment of Noise in BC Women's Hospital Operating Rooms

Conditions
-----------------
Noise Levels

Intervention / Treatment
-----------------
* Other: Noise measurement


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: BCW staff members Presence in OR during Cesarean section Willing to have a personal dosimeter pinned to hospital scrubs lapel Exclusion Criteria: - unable to read and understand English for the purpose of informed consent and perioperative communication
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Noise measurement|We will be measuring noise levels in the operating room|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| noise levels in decibels (dBs) | during cesarean section | 1.5 hours | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
noise, obstetric, operating rooms
Chitosan Chewing Gum Study in Dialysis Patients

Study Overview
=================
Brief Summary
-----------------
The purpose of the pilot study is to determine the impact of short-term administration of chitosan-containing chewing gum on phosphate levels in patients with elevated serum phosphate levels.

Detailed Description
-----------------
The impact of using salivary phosphate binders in ESRD patients is not fully known. The purpose of the pilot study is to determine the impact of short-term administration of chitosan-containing chewing gum on phosphate levels in patients with elevated serum phosphate levels.

Official Title
-----------------
A Pilot Study of Dietary Chitosan Chewing Gum in Dialysis Patients

Conditions
-----------------
End Stage Renal Disease

Intervention / Treatment
-----------------
* Dietary Supplement: Chitosan


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age 18-64 years old ESRD receiving hemodialysis serum phosphate > 6.0 mg/dL Exclusion Criteria: Unable to sign consent

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 64 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients receiving chronic hemodialysis<br>Dialysis patients chewing chitosan-containing gum | Dietary Supplement: Chitosan<br>* The product chitosan is contained in a chewing gum formulation<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Serum phosphate | Serum phosphate will be drawn 3 times per week over 2 weeks (during gum therapy), then once at 4 weeks and once at 6 weeks. | 6 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Salivary phosphate levels | Salivary phosphate will be assessed 3 times per week over 2 weeks (during gum therapy), then once at 4 weeks and once at 6 weeks. | 6 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
chitosan, kidney disease, salivary phosphate, serum phosphate
Breast Density and the Role of Preoperative Mammography, Ultrasound, Elastography and MRI

Study Overview
=================
Brief Summary
-----------------
To determine the sensitivity, specificity, and accuracy of preoperative ultrasound, elastography, mammography and breast MRI in women with dense breast tissue diagnosed with breast cancer; to test whether elastography or MRI can improve upon routine mammogram and conventional ultrasound in women with dense breast tissue.

Official Title
-----------------
A Prospective Study Evaluating Breast Density and the Role of Preoperative Mammography, Ultrasound, Elastography, and Magnetic Resonance Imaging in the Detection of Breast Cancer

Conditions
-----------------
Breast Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria:- Patients must have a suspicious breast lesion detected by a physical exam, mammography or U/S . that has not been surgically resected and is being considered to undergo biopsy if clinically indicated. Patients must be >= 18 and < 80 years of age, and female. Patients must have the ability to understand and the willingness to sign a written informed consent document. Exclusion Criteria:- Patients who have already had primary surgical excision of the suspicious finding <18 or >80 years of age Pregnant or Lactating Women

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Screening for Undiagnosed Type 2 Diabetes in New Classes of Subjects at High Risk

Study Overview
=================
Brief Summary
-----------------
The study aims to evaluate IFG, IGT or unknown type 2 diabetes mellitus in new classes at high risk to develop alterations of glucose metabolism and definition of new pathogenic mechanisms of insulin resistance and atherosclerosis. The following classes of subjects at high risk will be considered:First degree relatives of patients with type 2 diabetes mellitus, patients with cardiovascular disease and stroke, patients with heart valve disease. age will be > 30 years, both gender.

Detailed Description
-----------------
The primary outcome of the study is evaluation of glucose tolerance, insulin sensitivity and insulin secretion before and 2 hours post-glucose load Secondary outcomes are evaluation of endothelial function, of natriuretic peptides and free fatty acids, and inflammation before and 2 hours post-glucose load. New candidate genes will be also evaluated.

Official Title
-----------------
New Physiopathogenics Mechanisms Susceptible of Pharmacological Developments (Insulin Resistance and Atherosclerosis)

Conditions
-----------------
Diabetes Mellitus, Type 2

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Fasting glucose levels <126 mg/dl Age >30 years Both male and female Exclusion Criteria: Type 1 diabetes Known type 2 diabetes mellitus Pregnancy Impaired kidney and liver function Previous history of malignancies

Ages Eligible for Study
-----------------
Minimum Age: 30 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1,2,3<br>First degree relatives of patients with type 2 diabetes Patients with cardiovascular disease and stroke patients with heart valve disease | |
| 4<br>Healthy controls | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
cardiovascular disease, glucose intolerance, type 2 diabetes, endothelial dysfunction, inflammation, Age> 30 years, male and female, Fasting glucose below 126 mg/dl
Low Speed Drilling Versus Conventional Drilling Technique on Crestal Bone Level in Maxilla.(Group A ) A Randomized Controlled Clinical Trial

Study Overview
=================
Brief Summary
-----------------
20 patients were selected requiring implant placement and divided randomly into two groups (10 in each group) for the study group, starter drill is used to locate the point of insertion as planned then pilot drill is also used to the full desired working length after that all other sequential drills are used at a low speed (50-70 rpm) without irrigation . In the study group: implant will be inserted in the low speed osteotomy site. • In the control group: implants will be inserted in the conventional prepared osteotomy site. For both groups there is no surgical guide used. The flap will then be copiously irrigated with saline in preparation for closure. The flap will then be closed using interrupted 4/0 resorbable sutures.

Official Title
-----------------
Clinical Evaluation of the Effect of Low Speed Drilling Versus Conventional Drilling Technique on Crestal Bone Level in Maxilla. A Randomized Controlled Clinical Trial

Conditions
-----------------
Bone Resorption

Intervention / Treatment
-----------------
* Procedure: Drilling at low speed
* Procedure: Conventional drilling at high speed


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients restoring missing maxillary teeth with implant placement. Both sexes. Age: 25-45 Mesio-distal dimensions: Not less than 6 mm Bone Height: Not less than 12 mm Bucco-lingual dimensions: Not less than 8mm All measures will be assessed using CBCT. Exclusion Criteria: Sites needing bone grafting or augmentation. Heavy smokers more than 20 cigarettes per day. Patients with systemic disease that may affect normal healing.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Biologic drilling drilling at low speed<br> | Procedure: Drilling at low speed<br> <br> |
| Active Comparator: conventional drilling drilling at high speed<br> | Procedure: Conventional drilling at high speed<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| crestal bone loss | measurement from radiographic analysis using digital periapical x-ray | [Time Frame: 6 month] | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| patient morbidity after procedure | pain value on pain scale | [Time Frame: 1 day] | 
| Implant stability value | resonance frequency analysis using osstell | [Time Frame: 3 month] |
Apolipoprotein D (ApoD) In Human Serum As Marker Of Parkinson's Disease

Study Overview
=================
Brief Summary
-----------------
In Italy affected people are 200,000 and every year Parkinson new cases are 10,000. Aging is the principle risk factor of Parkinson with the possibility of its development doubling every five years after 65. Because of the increase of the social longevity and aging as the main risk factor, there are many repercussions on the health system (hospital stays and pharmaceutical costs) as on the social system (assistance- related problems). Parkinson's disease exerts an extremely negative impact on life's quality of the patient. In fact, because of Parkinson symptoms (tremor, dribble, etc), patient's social life will be reduced with the consequent development of the depression. Consequently, the early detection and treatment of Parkinson's is necessary. To achieve this goal, Apolipoprotein D (ApoD) in human serum as a marker of the oxidative stress-inflammation vicious cycle seems most promising candidate for diagnosis.

Detailed Description
-----------------
Total participants: n=180. Study Part 1: Health persons: n=90; Groups of health persons: n=3; Subjects per group: n=30. Study Part 2: Patients: n=90; Groups of patients: n=3; Subjects per group: n=30.

Official Title
-----------------
Detection of Apolipoprotein D (ApoD) in Human Serum as Marker of Parkinson's Disease

Conditions
-----------------
Parkinson's

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with Parkinson's disease in the pathological related stages (Hoehn and Yahr) Persons > 20 years Exclusion Criteria: Patients with a neurodegenerative disorder different to Parkinson's disease Patients, who are post-ictus and/or traumatic brain injury (TBI) Patients, who are treated with antipsychotic drugs Obese persons (BMI > 27) Idiopathic normal pressure idrocephalus (INPI) Paget's disease Breast cancer Adenocarcinoma of the prostate Glucose-6-phosphate (GSD-I) deficiency Insuline-resistance-related disorders

Ages Eligible for Study
-----------------
Minimum Age: 20 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group I<br>Healthy Subjects aged 20-40 | |
| Group II<br>Healthy Subjects aged 40-65 | |
| Group III<br>Healthy Subjects aged more than 65 | |
| Group A<br>Patients at Stage I, H&Y classification | |
| Group B<br>Patients at Stage II, H&Y classification | |
| Group C<br>Patients at Stage more than III, H&Y classification | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Detection of Apolipoprotein D | Apolipoprotein D (apoD)concentration in human serum as a potential marker for Parkinson's disease (PD) | Baseline |