A Comparison Between Child-Pugh and Albumin-Bilirubin Scores

Study Overview
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Brief Summary
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To compare Child-Pugh and Albumin-Bilirubin scores in patients with spontaneous rupture of hepatocellular carcinoma

Detailed Description
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To compare Child-Pugh and Albumin-Bilirubin scores in patients with spontaneous rupture of hepatocellular carcinoma. And to determine which is better in predicting long-term survival and short-term survival.

Official Title
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A Comparison Between Child-Pugh and Albumin-Bilirubin Scores in Patients With Spontaneous Rupture of Hepatocellular Carcinoma: A Retrospective Study

Conditions
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Rupture, Spontaneous, Rupture Liver, Hepatocellular Carcinoma, Hepatic Impairment

Intervention / Treatment
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* Procedure: Liver resection
* Other: Transcatheter arterial embolization


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Be diagnosed as hepatocellular carcinoma pathologically; had a tumor rupture confirmed by Intraperitoneal exploration or clinical signs and symptoms in combination with imaging examination. Exclusion Criteria: Be diagnosed as not hepatocellular carcinoma pathologically；had repeated transcatheter arterial chemoembolization(TACE) or a long history (more than 1 year) of cancer treatment; loss of follow up or without complete data.

Ages Eligible for Study
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Minimum Age: 15 Years
Maximum Age: 76 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Surgical treatment<br>Patients who received liver resection or palliative surgery, such as microwave coagulation therapy, hepatic artery ligation, or suturing ligation. | Procedure: Liver resection<br>* Liver resection was comprised of single or multiple liver resections aiming to excise all macroscopic tumors.<br>|
| Non-surgical treatment<br>Patients who received transcatheter arterial embolization (or transcatheter arterial chemoembolization) or conservative treatment | Other: Transcatheter arterial embolization<br>* Transcatheter arterial embolization or transcatheter arterial chemoembolization can localize the bleeding point and provide interventional embolization.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overall survival of all patients | Overall survival of all patients among different Child-Pugh and albumin-bilirubin scores | 5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Short-term mortality of all patients | Ninety-day mortality of all patients among different Child-Pugh and albumin-bilirubin scores | Ninety days | 
| Short-term mortality of surgical subgroup | Ninety-day mortality of the surgical subgroup among different Child-Pugh and albumin-bilirubin scores | Ninety days | 
| Short-term mortality of non-surgical subgroup | Ninety-day mortality of the non-surgical subgroup among different Child-Pugh and albumin-bilirubin scores | Ninety days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Spontaneous rupture, survival, hepatocellular carcinoma, Child-Pugh, Albumin-bilirubin