Macular Hole Surgery With and Without Internal Limiting Membrane Peeling：A Systematic Review and Meta-analysis

Study Overview
=================
Brief Summary
-----------------
Since Kelly and Wendel first reported successful closure of idiopathic macular holes (MH) by vitrectomy in 1991, many surgical modifications have been made to improve the anatomical and visual outcomes of this surgery. Recently, internal limiting membrane (ILM) peeling has become used widely as an adjunctive procedure during MH surgery because the removal of ILM is thought to reduce the tangential traction on the macula, a major factor in the pathogenesis of idiopathic macular holes. However, the role of ILM peeling in macular hole surgery is not yet well defined. To the best of our knowledge, there is no meta-analysis on comparison of the efficacy of ILM peeling and suture for MH surgery. This study reviewed the published literature comparing surgical results with and without ILM peeling and and performed a meta-analysis to determine whether there is any benefit or detriment anatomically and/or visually.

Official Title
-----------------
Macular Hole Surgery With and Without Internal Limiting Membrane Peeling：A Systematic Review and Meta-analysis

Conditions
-----------------
Macular Holes

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Eligible participants are those with idiopathic FTMH in stages 2-3, of less or equal than 18 months duration (based on symptoms reported by the patient) and with a visual acuity equal to or worse than 20/40 in the study eye. Exclusion Criteria: Patients with idiopathic FTMH stages 2-3 but longer than 18 months duration or with other causes of decreased vision (e.g. corneal scarring, age-related macular degeneration, diabetic retinopathy, glaucoma if central and/or paracentral absolute visual field defects are present) and Those with FTMH related to high myopia (> 6 dioptres) or trauma will be excluded from the study.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| ILM-on group<br>patients were scheduled to undergo macular hole surgery without internal limiting membrane (ILM) peeling | |
| ILM-off group<br>patients were scheduled to undergo macular hole surgery with internal limiting membrane (ILM) peeling | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Anatomic Success rate | Anatomic success defined as a closed hole without a visible edge or a flat hole without a rim of subretinal fluid. | 12 months | 
| Functional Success Rate | Functional Success defined as an improvement of 2 or more Snellen BCVA. | 12 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Best-corrected visual acuity | All Snellen BCVA were converted to logarithm of the minimum angle of resolution (logMAR) BCVA | 12 month | 
| Complications | Such as elevated intraocular pressure,retinal tear,rhegmatogenous retinal detachment | 12 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Macular Holes, Internal limiting membrane, peeling, Surgery