Complications Associated With Central Venous Access in the NSICU: PICC vs CVC

Study Overview
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Brief Summary
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The goal of this study is to determine whether Peripherally Inserted Central Catheter or Centrally Inserted Venous Catheters have lower complication rates in the Neuroscience Intensive Care Unit. After admission to the Neuroscience ICU and if they require central access, patients will be randomized to receive a PICC or CVC and complications (such as pneumothorax, deep venous thrombosis, infection, etc.) will be tracked and compared between the two interventions.

Official Title
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Complications Associated With Central Venous Access in the NSICU: PICC vs CVC

Conditions
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PICC, Central Venous Catheter, Central Line, Neuro ICU, Neuroscience ICU, CVC

Intervention / Treatment
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* Device: peripherally inserted central catheter
* Device: centrally inserted central catheter


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adult patients admitted to the NSICU, who require central access for the treatment of their illness. Exclusion Criteria: Current or recent (within 1 month) diagnosis of bacteremia Current or recent (within 1 year with confirmed resolution by imaging) deep venous thrombosis Existing central access Non-English speaking Requirement for emergent central access and unable to obtain consent in an emergency setting

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: PICC<br>Patients randomly assigned to receive a peripherally inserted central catheter and they will be monitored for either having a complication or no complication. | Device: peripherally inserted central catheter<br>* Any complication associated with central access<br>|
| Active Comparator: CVC<br>Patients randomly assigned to receive a centrally inserted central catheter and they will be monitored for either having a complication or no complication. | Device: centrally inserted central catheter<br>* Central access not associated with any complication<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Participants With Complications With Central Access Including Insertion | Aggregation of all complications associated with central access including insertion | up to 10 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of Participants With Deep Venous Thrombosis |  | up to 10 weeks | 
| Number of Patients With Complications Related to Insertion | Any complication of insertion including technical failure | From the time of insertion until first confirmatory chest X-ray | 
| Number of Participants With a Central Line Associated Blood Stream Infection | A Central access associated infection (CLABSI) | up to 10 weeks |