NMES During the Day and Prior to Sleep

Study Overview
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Brief Summary
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In the present study, the effect of a bolus of intrinsically labeled milk directly after one-legged NMES (Neuromuscular Electrical Stimulation) will be studied under two conditions: during the day and prior to sleep

Detailed Description
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In the present study, the effect of a bolus of intrinsically labeled milk directly after an hour of one-legged NMES (Neuromuscular Electrical Stimulation) will be studied under two conditions: during the day and immediately prior to sleep

Official Title
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The Effect of Neuromuscular Electrical Stimulation on Post-prandial Protein Accretion During the Day and Prior to Sleep

Conditions
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Sarcopenia

Intervention / Treatment
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* Procedure: Dietary protein plus NMES during the day
* Procedure: Dietary protein plus NMES prior to sleep


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 65-85 years Male 18.5 ≤ BMI ≤ 30.0 Exclusion Criteria: Type II diabetes All co morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthrosis, arthritis, spasticity/rigidity, all neurological disorders, paralysis, hip/knee surgery). Use of anticoagulants, blood diseases, allergy for lidocaine Use of NSAIDs (non-steroidal anti-inflammatory drugs) and acetylsalicylic acid Patients suffering from PKU (Phenylketonuria) Presence of implantable cardioverter defibrillator and/or pacemaker Performed regular resistance type exercise in the past 6 months Use of any tools to assist during walking (cane/ crutches/ walker) (Partial) foot/ leg amputation

Ages Eligible for Study
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Minimum Age: 65 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Treatment during the day<br>Neuromuscular electrical stimulation after a protein bolus, performed during the day | Procedure: Dietary protein plus NMES during the day<br>* Neuromuscular electrical stimulation after a protein bolus, performed during the day<br>|
| Active Comparator: Treatment prior to sleep<br>Protein ingestion directly after one-legged NMES, directly prior to sleep | Procedure: Dietary protein plus NMES prior to sleep<br>* Neuromuscular electrical stimulation after a protein bolus, performed prior to sleep<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incorporation of stable isotope amino acids into skeletal muscle tissue |  | 4-8 hours in the postprandial phase | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Plasma amino acid enrichment |  | 4-8 hours in the postprandial phase | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Neuromuscular electrical stimulation, Ageing, Protein ingestion