Response to Endotracheal Tube Intubation at Different Time of Fentanyl Given During Induction

Study Overview
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Brief Summary
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Opioids have been used to modify the hemodynamic response associated with laryngoscopy and tracheal intubation. To seek the correlation of Fentanyl given time, we will analysis the data collected from vital signs monitoring machine. Patients'details will be recorded too.

Detailed Description
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Laryngoscopy and intubation often provoke hypertension and tachycardia due to the stimulation both sympathetic and sympathoadrenal activities. While the adverse hemodynamic effects of laryngoscopy and endotracheal intubation can precipitate myocardial ischemia, even in patients without hypertension, the responses are exaggerated in patients with hypertension . In the previous studies , many drugs, including opioids and beta-blockers, have been used to modify the hemodynamic response associated with laryngoscopy and tracheal intubation. To seek the correlation of Fentanyl given time, we will analysis the data collected from vital signs monitoring machine. All patients were premedicated with Midazolam 0.1mg/kg , Lidocaine 0.5mg/kg (L), Propofol 2mg/kg (P), Rocuronium 1mg/kg (R) before induction of general anesthesia. Laryngoscopy lasting a maximum of 30 s was attempted 3 min after administration of the induction agents. Fentanyl 2mcg/kg was given at different time before intubation.

Official Title
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The Hemodynamic Response to Endotracheal Intubation at Different Time of Fentanyl Given During Induction: a Randomized Controlled Trial

Conditions
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Intubation, Intratracheal

Intervention / Treatment
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* Other: Different given time


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: with American Society of Anesthesiologists (ASA) physical status classification 1&2 undergo elective surgery intubation Exclusion Criteria: Opioids allergy history

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 3mins<br>Different given time: Fentanyl 2mcg/kg was given at either time 3 minutes before intubation | Other: Different given time<br>* Fentanyl 2mcg/kg (F) was given at either 1,2,3 minutes before intubation<br>|
| Active Comparator: 2mins<br>Different given time: Fentanyl 2mcg/kg was given at either time 2 minutes before intubation | Other: Different given time<br>* Fentanyl 2mcg/kg (F) was given at either 1,2,3 minutes before intubation<br>|
| No Intervention: control<br>Different given time: Fentanyl 2mcg/kg was given at either time 1 minute before intubation | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| heart rate | heart rate | 0-10 minutes during induction | 
| systolic blood pressure | systolic blood pressure | 0-10 minutes during induction | 
| diastolic blood pressure | diastolic blood pressure | 0-10 minutes during induction | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Intubation, Intratracheal