Hyperglycemia, Exercise, and Endothelial Function

Study Overview
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Brief Summary
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The main purpose of this study is to determine if exercise preserves vascular function during hyperglycemia. All subjects will consume a sugary beverage three times daily for seven days. Subjects will be randomly assigned to either the glucose with (GLU+EX) or without (GLU) structured exercise group.

Detailed Description
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Acute (oral glucose tolerance test) and chronic (type 2 diabetes) hyperglycemia are associated with impaired endothelial function. Both a single bout of exercise and chronic exercise training are associated with improvements in vascular endothelial function. It remains unknown if exercise can preserve vascular endothelial function during hyperglycemia.

Official Title
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Effect of Short-Term Glucose Loading on Vascular Function

Conditions
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Endothelial Function, Hyperglycemia

Intervention / Treatment
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* Behavioral: GLU+EX
* Dietary Supplement: GLU


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: - Healthy young men 18-35 years of age. Exclusion Criteria: Hypertension, Hyperlipidemia, Smoking, Heart disease, Chest pain upon exertion, Previous heart surgeries or history of arrhythmias, Diabetes, Obesity (body mass index ≥30kg/m2), Kidney disease, Pulmonary disease, Autonomic disorders, Individuals whom engage in structured exercise (≥30min, ≥2d/wk), Current use of medications which influence outcome measures

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Randomized
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: GLU+EX<br>Subjects will consume a 75g glucose beverage three times daily for seven days while participating in five structured aerobic exercise sessions throughout the experimental protocol. | Behavioral: GLU+EX<br>* Subjects will complete 45 minutes of recumbent cycling at 60-65% of age-predicted maximal heart rate five times over seven days while ingesting a 75g glucose beverage three times daily.<br>|
| Active Comparator: GLU<br>Subjects will consume a 75g glucose beverage three times daily for seven days without participating in structured aerobic exercise. | Dietary Supplement: GLU<br>* Subjects will consume a 75g glucose beverage three times daily over a seven-day period.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Vascular Endothelial Function | Brachial artery flow-mediated dilation (%), measured via Doppler ultrasound, will be assessed before and after the intervention. | Before and after the seven-day intervention in both groups. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Central Blood Pressure | Aortic blood pressure will be derived from radial artery pressure wave measurements (via applanation tonometry) during resting conditions. | Before and after the seven-day intervention in both groups. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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exercise, glucose, vascular function