PTCCO2 Monitoring During Retroperitoneoscopic Urologic Surgery

Study Overview
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Brief Summary
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To investigate the accuracy and correlation of estimating arterial CO2 pressure（PaCO2） using a transcutaneous CO2 pressure（PTCCO2） monitor in patients undergoing retroperitoneoscopic renal or adrenal surgery.

Detailed Description
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30 patients undergoing retroperitoneoscopic renal or adrenal surgery were included in this study.Their PaCO2, PetCO2, and PTCCO2values were measured at 3 time points before and 30min, 60min after pneumoperitoneum and calculated the different between each measure(PetCO2 and PTCCO2) and PaCO2. Agreement among measures was assessed by the Bland-Altman method.

Official Title
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The Application of Transcutaneous CO2 Partial Pressure Monitoring in the Anesthesia of Patients Undergoing Retroperitoneoscopic Urologic Surgery

Conditions
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Retroperitoneoscopic Urologic Surgery, Transcutaneous Carbon Dioxide Partial Pressure Monitoring

Intervention / Treatment
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* Device: transcutaneous monitor (TCM-4 monitor)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients undergoing retroperitoneoscopic renal or adrenal surgery Age more than 16 years. Exclusion Criteria: Care taker unable or unwilling to give oral informed consent Patients with history of severe trauma, operations, smoking, and severe cardiovascular or respiratory diseases, such as coronary heart disease, congestive heart failure, or chronic obstructive pulmonary disease 4.Subject has a condition or allergy which would prohibit placing the probe 5.Subject has participated in a trial with any experimental drug or device trial within 30 days prior to enrollment in the study

Ages Eligible for Study
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Minimum Age: 16 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: retroperitoneoscopic urologic surgery<br>All included patients will undergo retroperitoneoscopic renal or adrenal surgery with the transcutaneous carbon dioxide monitor. | Device: transcutaneous monitor (TCM-4 monitor)<br>* TCM-4 monitor, which had changed new electrode membrane and was calibrated by the same person(who had been trained systematically) before each placement. The electrode should be heated to 44℃, then fixed it to the anterior part of chest in the location of lateral position after remove grease by alcohol. The positon of electrode must be changed every 2 hours in order to avoid thermal injury, and should be calibrated again.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Bias and precision of the transcutaneous carbon dioxide measurements | correlation and agreement between PetCO2 and PaCO2 and PTCCO2 | 0 minutes(baseline) | 
| Bias and precision of the transcutaneous carbon dioxide measurements | correlation and agreement between PetCO2 and PaCO2 and PTCCO2 | 30 minutes | 
| Bias and precision of the transcutaneous carbon dioxide measurements | correlation and agreement between PetCO2 and PaCO2 and PTCCO2 | 60 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| complication: appearance of signs of thermal injury (redness, skin erythema, blisters, necrosis) under application of transcutaneous sensor temperatures of 44°C ) | While the sensor temperatures heated to 44°C, the skin will be closely observed for any kind of thermic tissue damage | 0 minutes(baseline) | 
| complication: appearance of signs of thermal injury (redness, skin erythema, blisters, necrosis) under application of transcutaneous sensor temperatures of 44°C ) | While the sensor temperatures heated to 44°C, the skin will be closely observed for any kind of thermic tissue damage | 30 minutes | 
| complication: appearance of signs of thermal injury (redness, skin erythema, blisters, necrosis) under application of transcutaneous sensor temperatures of 44°C ) | While the sensor temperatures heated to 44°C, the skin will be closely observed for any kind of thermic tissue damage | 60 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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transcutaneous carbon dioxide, retroperitoneoscopic, urologic surgery, anesthesia