Tongzhou Cohort Study

Study Overview
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Brief Summary
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The present study aimed to investigate the impact of obesity on long-term cardiovascular risk in elderly patients with hypertension.

Detailed Description
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Overweight status and obesity are important risk factors leading to hypertension, poor blood pressure control, and poor prognosis. However, the studies focused on elderly patients with hypertension are limited. Therefore, the aim of the present study was to evaluate the long-term impact of obesity on cardiovascular risk in elderly patients with hypertension.

Official Title
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Cardiovascular Risk in Elderly Obese Patients With Hypertension During Rapid Urbanization of Tongzhou District: A Cohort Study

Conditions
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Obesity, Hypertension

Intervention / Treatment
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* Other: No intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Ages of ≥ 60 years History of hypertension and treatment with anti-hypertension drugs for more than 4 weeks Availability for follow-up until 2026 No major barriers to provide written consent Exclusion Criteria: NA

Ages Eligible for Study
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Minimum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Obese hypertensive group<br>Patients who were diagnosed with obesity (body mass index (BMI)≥28kg/m2) and hypertension (systolic blood pressure (SBP)/diastolic blood pressure (DBP) ≥ 140/90 mmHg). | Other: No intervention<br>* This is an observational study without any intervention<br>|
| Overweight hypertensive group<br>Overweight patients (24 kg/m2≤BMI≤28 kg/m2) diagnosed with hypertension (SBP/DBP≥140/90 mmHg). | Other: No intervention<br>* This is an observational study without any intervention<br>|
| Lean hypertensive group<br>Lean patients (BMI ≤ 24 kg/m2) diagnosed with hypertension (SBP/DBP ≥ 140/90 mmHg). | Other: No intervention<br>* This is an observational study without any intervention<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percentage of participants with major adverse cardiovascular events (MACEs) | Percentage of participants with major adverse cardiovascular events (MACEs), including all-cause death, nonfatal myocardial infarction (MI), nonfatal stroke and coronary revascularization. | 2021-2026 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percentage of participants with all-cause death | Percentage of participants with cardiovascular, non-cardiovascular and undetermined death. | 2021-2026 | 
| Percentage of participants with MI | Percentage of participants with fatal and nonfatal MI. | 2021-2026 | 
| Percentage of participants with stroke | Percentage of participants with fatal and nonfatal stroke. | 2021-2026 | 
| Percentage of participants undergoing coronary revascularization | Percentage of participants undergoing ischemia- and non-ischemia-driven coronary revascularization. | 2021-2026 | 
| Change in BP control rate | Change in BP control rate (office BP: SBP < 140 mmHg and DBP < 90 mmHg) from baseline to follow-up. | 2021-2026 | 
| Change in SBP | Change in SBP from baseline to follow-up. | 2021-2026 | 
| Change in estimated glomerular filtration rate (eGFR) | Change in estimated glomerular filtration rate (eGFR) in ml/min/1.73m2 from baseline to follow-up. | 2021-2026 | 
| Change in low-density lipoprotein-cholesterol (LDL-c) | Change in low-density lipoprotein-cholesterol (LDL-c) in mmol/L from baseline to follow-up. | 2021-2026 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Obesity, Hypertension, Cardiovascular risk