Biomarkers to Predict Response to Interferon Therapy in Patients With Melanoma

Study Overview
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Brief Summary
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RATIONALE: Collecting and storing samples of blood from patients with cancer to study in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer, and may help doctors learn how well patients will respond to treatment. PURPOSE: This laboratory study is looking at biomarkers to predict the response to interferon therapy in patients with melanoma.

Detailed Description
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OBJECTIVES: Generate a comprehensive multiplexed array of melanoma-associated serological markers and validate it using serum samples from patients with melanoma and healthy control participants. Determine changes in the profile of serological markers induced by interferon-alfa 2b (IFN-α2b) therapy. Define panels of serological markers with prognostic and predictive power for IFN-α2b therapy responses in patients with melanoma. OUTLINE: This is a multicenter study. Serum samples are used for multiplex analyses. Biomarkers to be assessed include cytokines, chemokines, growth factors, angiogenic and antiangiogenic molecules, matrix metalloproteases (MMPs), tissue inhibitors of MMPs (TIMPs), melanoma-associated antigens, basic fibroblast growth factor, insulin-like growth factor I and II, thrombospondin, endostatin, angiostatin, vasostatin, and vascular endothelial growth factor inhibitor. PROJECTED ACCRUAL: A total of 1,716 samples will be accrued for this study.

Official Title
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Multiplex Analysis of Serum Biomarkers for Prediction Interferon Therapy Response in Melanoma Patients

Conditions
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Melanoma (Skin)

Intervention / Treatment
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* Other: laboratory biomarker analysis


Participation Criteria
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Eligibility Criteria
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DISEASE CHARACTERISTICS: Diagnosis of melanoma OR healthy volunteer (control) PATIENT CHARACTERISTICS: Not specified PRIOR CONCURRENT THERAPY: Not specified

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 120 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: laboratory biomarker analysis|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Generation of a comprehensive multiplexed array of melanoma-associated serological markers | Generation of a comprehensive multiplexed array of melanoma-associated serological markers | 1 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in the profile of serological markers induced by interferon-alfa 2b therapy | Changes in the profile of serological markers induced by interferon-alfa 2b therapy | 1 month | 
| Panels of serological markers with prognostic and predictive power for interferon-alfa 2b response | Panels of serological markers with prognostic and predictive power for interferon-alfa 2b response | 1 month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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recurrent melanoma, stage IV melanoma, stage IA melanoma, stage IB melanoma, stage IIA melanoma, stage IIB melanoma, stage IIC melanoma, stage IIIA melanoma, stage IIIB melanoma, stage IIIC melanoma