Skeletal Health of Klinefelter Patients

Study Overview
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Brief Summary
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This study compared the bone health of KS patients who were actively monitored in our clinic by dual-energy X-ray absorptiometry (DXA) with that of a control group of healthy volunteers.

Detailed Description
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Klinefelter syndrome (KS) is the most common chromosome number abnormality of men, occurring in 1/500 to 1/1000 live births . It was first described in 1942 as an endocrine disorder characterised by small, hard testicles androgen deficiency, gynaecomastia and increased follicle stimulating hormone (FSH). Osteoporosis is a progressive bone remodelling disorder in which bone loss exceeds bone formation. The resulting micro-architectural defects and bone fragility are associated with increased fracture risk and mortality. In KS, testosterone deficiency is associated with decreased bone mass and low bone mineral density (BMD) , and a positive correlation of total serum testosterone and BMD has been reported . There are some exceptions ; however, most studies have reported that KS increases the risk of osteopenia and osteoporosis compared with age-matched control groups.

Official Title
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Skeletal Health of Klinefelter Patients is Not so Bad

Conditions
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Osteoporosis

Intervention / Treatment
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* Diagnostic Test: dual-energy X-ray absorptiometry


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: diagnosis of klinefelter Exclusion Criteria: klinefelter subjects with a history of hip or waist surgery or trauma for control group with known bone disease, unknown fertility hypogonadism findings on physical examination (e.g. low testicular volume or abnormal body hair), known hypogonadism, previous androgen replacement therapy any drug therapy affecting bone metabolism

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Screening
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: To compare bone mineral density of klinefelter patients and normal population
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Klinefelter<br>Male patients followed with the diagnosis of klinefelter | Diagnostic Test: dual-energy X-ray absorptiometry<br>* dual-energy X-ray absorptiometry<br>|
| Active Comparator: Control<br>healthy male subjects | Diagnostic Test: dual-energy X-ray absorptiometry<br>* dual-energy X-ray absorptiometry<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| BMD | bone mineral density | T score obtained from dual-energy X-ray absorptiometry through study completion, an average of 2 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Klinefelter, Osteoporosis, dual-energy X-ray absorptiometry