High-Intensity Interval Training and Fat Mass Losses

Study Overview
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Brief Summary
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The aims of this study was to compare two isoenergetic HIIT (High-intensity Interval training) programs (cycling vs. running) on body composition, substrate oxidation at rest and during a moderate exercise, muscle functionality, glycaemic control, lipid profile, inflammation, maximal aerobic capacity (VO2max) and gut microbiota composition in men with overweight or obesity. The investigators hypothesized that both programs could decrease total, abdominal and visceral fat mass but due to differences in muscle solicitation, metabolism adaptation and blood flow, and that running could favors greater fat mass losses.

Detailed Description
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The first aim of this study was to compare two isoenergetic HIIT programs (cycling vs. running) on body composition in men with overweight or obesity. 20 men with overweight or obesity should completed HIIT program three times a week during twelve weeks. i) High intensity interval training - BIKE (HIIE BIKE) 10 cycles of speeding up for 45 s at 80-thPHR followed by pedaling slowly (40% thPHR) for 1m30s (37min30s) ii) High intensity interval training - RUN (HIIE RUN) 9 cycles of speeding up for 45 s at 80-thPHR followed by pedaling slowly (40% thPHR) for 1m30s (35min15s) Body composition will be measured before and after HIIT program by Dual-energy X-ray absorptiometry (DXA).

Official Title
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Effect of Two Isoenergetic Modes of High-Intensity Interval Training on Total and Abdominal Fat Mass Loss in Men With Overweight or Obesity.

Conditions
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Overweight and Obesity, Men

Intervention / Treatment
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* Other: Physical activity


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: men (18 to 65 years old) with overweight or obesity (BMI > 25 kg/m2 and ≤ 40 kg/m2) Exclusion Criteria: medical contraindications to intense physical activity, painful joints, taking ß-blocker

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: 2 groups : running vs cycling
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: High intensity interval training - BIKE (HIIE BIKE)<br>10 cycles of speeding up for 45 s at 80-thPHR followed by pedaling slowly (40% thPHR) for 1m30s (37min30s) | Other: Physical activity<br>* Comparison of HIIT mode (running vs cycling)<br>|
| Experimental: High intensity interval training - RUN (HIIE RUN)<br>9 cycles of speeding up for 45 s at 80-thPHR followed by pedaling slowly (40% thPHR) for 1m30s (35min15s) | Other: Physical activity<br>* Comparison of HIIT mode (running vs cycling)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| HIIT mode and fat mass change (g) | change of total fat mass (in grams from DXA analysis) after 3 months of training- HIIT mode comparison | At the first and the last training - week 1 and 12 | 
| HIIT mode and abdominal fat mass change (g) | change of abdominal fat mass (in grams from DXA analysis) after 3 months of training- HIIT mode comparison | At the first and the last training - week 1 and 12 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of carbohydrate and lipid oxidation (g.min-1) during a sub-maximal exercise by measuring gaz exchange. | Carbohydrate and lipid oxidation rate (g.min-1) during a submaximal exercise before and after the HIIT protocol. HIIT mode comparison. | At the first and the last training - week 1 and 12 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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cycling, running, high-intensity interval training, fat mass, visceral tissue, health