Tissue and Functional Assessment of Myocardial Injury in Hodgkin Lymphoma (HL) Survivors

Study Overview
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Brief Summary
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This study will test whether cardiac MRI can improve early detection of Hodgkin lymphoma associated heart disease compared to a stress echocardiogram. By doing both stress echocardiography and cardiac MRI, we will compare the ability of the two tests to detect heart disease.

Official Title
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Tissue and Functional Assessment of Myocardial Injury in Hodgkin Lymphoma (HL) Survivors

Conditions
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Hodgkin Lymphoma Survivor

Intervention / Treatment
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* Other: Clinical Assessment
* Procedure: Stress cardiac MRI
* Procedure: Stress echocardiogram


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Classical or nodular lymphocyte predominant HL treated at Memorial Sloan-Kettering Cancer Center. Age ≥ 18 years Treatment for HL that included mediastinal RT at initial diagnosis or relapse. ≥ 5 years from last HL treatment. Exclusion Criteria: Primary HL diagnosis prior to 1980. Additional mediastinal RT or subsequent cardiotoxic systemic therapy for secondary malignant neoplasm. Known CAD/CHF (defined as documented myocardial infarction, cardiac revascularization, angiographic obstructive CAD, or decreased LV function [EF < 55%] during prior clinical care). Contraindication to MRI (i.e. pacemakers, defibrillators, or aneurysm clips, or other implanted ferromagnetic objects), gadolinium (i.e. known hypersensitivity to gadolinium, advanced renal insufficiency as defined by glomerular filtration rate <30 ml/min/1.73m^2). Contraindication to exercise stress testing other than the above (i.e. unstable angina or severe valvular stenosis).

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Hodgkin Lymphoma Survivor<br>This is a prospective cross-sectional study of 200 HL survivors whose treatment included mediastinal RT at initial diagnosis or relapse, and are at least 5 years from last HL treatment. | Other: Clinical Assessment<br>* HL treatment will be determined by review of available medical records as archived at MSKCC. Recorded variables will include: (1) RT - field, fractional and cumulative dose, and duration; (2) chemotherapy - regimen, planned interval, dose per cycle, and cumulative dosages. Patients will also be asked to complete the FACT-LYM questionnaire and the FACIT Fatigue questionnaire.<br>Procedure: Stress cardiac MRI<br>* Both imaging tests will be performed within a 30 day interval, with the two modalities interpreted by dedicated study investigators blinded to the results of the other modality.<br>Procedure: Stress echocardiogram<br>* Both imaging tests will be performed within a 30 day interval, with the two modalities interpreted by dedicated study investigators blinded to the results of the other modality.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| compare the prevalence of cardiac injury | detected by cardiac MRI to that detected by stress echocardiography among a broadly representative cohort of Hodgkin lymphoma survivors. | 2 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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MRI, stress echo, Clinical Assessment, 14-017