Response to Tregs in Innate Immunity Receptor LRP1 (CD91) and Tregs in Periferic Blood Mononuclear Cells in Patients With Non-segmentary Vitiligo

Study Overview
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Brief Summary
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This study aims to evaluate some differences in the immune system between patients with vitiligo and patients without the disease. These differences will be evaluated by the extraction of peripheral blood that will be analyzed before the treatment and after the treatment that, in the habitual way and at the discretion of the responsible dermatologist. Patients agreeing to participate in the study will be subjected to extraction of two tubes (20 ml) of peripheral blood (baseline) and after 12 weeks (+/- 5 days) of treatment. Therefore, neither treatment nor follow-up visits will be modified by participation, but will be the same whether or not participate in the study. In the case of controls, two peripheral blood tubes (20ml) will be removed in a single participation. Patients with vitiligo will also be asked to complete questionnaires to measure stress, depression and perception of disease (PSS-10, Skindex-29, HADS, Likert) before and after 12 weeks (+/- 5 days) of therapeutic intervention . This study will include 20 patients with active non-segmental vitiligo and 10 controls without the disease. The duration of participation in this study will be 12 weeks (+/- 5 days) for patients with vitiligo and a single participation (extraction of 20 ml of peripheral venous blood) for the controls.

Official Title
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Response to Tregs in Innate Immunity Receptor LRP1 (CD91) and Tregs in Periferic Blood Mononuclear Cells in Patients With Non-segmentary Vitiligo

Conditions
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VITILIGO

Intervention / Treatment
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* Diagnostic Test: CD 91 levels
* Diagnostic Test: Tregs


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: - Patient with vitiligo without treatment Exclusion Criteria: Patient with inmunosupressive disease Patient receiving vitiligo treatment

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Vitiligo untreated patients<br> | Diagnostic Test: CD 91 levels<br> <br> Diagnostic Test: Tregs<br> <br> |
| Control. Patients without vitiligo<br> | Diagnostic Test: CD 91 levels<br> <br> Diagnostic Test: Tregs<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Tregs levels |  | Baseline | 
| Tregs levels |  | 16 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| LRP1 (CD91) levels |  | Baseline | 
| LRP1 (CD91) levels |  | 16 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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TREGS, CD91, LRP1