Re-engagement at Discharge 2

Study Overview
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Brief Summary
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Early post-discharge mortality is high among Zambians living with HIV admitted to the hospital. This may be due to missed opportunities in post-discharge care, such as inadequate follow-up and treatment. In this study the investigators will develop and pilot a new approach to post-discharge HIV care to improve care coordination and treatment adherence.

Detailed Description
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Many people living with HIV (PLHIV) have poor outcomes following hospitalization, including high mortality, readmission, and gaps in HIV care engagement. This is likely multi-factorial and not all etiologies may be modifiable. While high mortality may due to incurable cancer, the majority of deaths in PLHIV are thought to be caused by infectious diseases for which treatments exist. However, succumbing to these life-threatening infections after discharge may be due to poor understanding of discharge instructions, lack of post hospital care, and poor understanding of required follow up. Psychosocial support also plays a role in the mental and physical health of these sick patients. In ReCharge 1, the investigators gathered formative data and identified at least three major factors that undermine HIV clinical outcomes after hospital discharge. First, there are gaps in continuity of care between the discharging facility and outpatient. Second, support from family is often suboptimal due to lack of understanding on the cause of illness, lack of HIV status disclosure, and the cost of care. Third, HIV comorbidities may underpin or complicate the immediate reason for discharge or the post-discharge engagement in care. These data were disseminated to local experts in Zambia including from the Ministry of Health and used to create a new care model for post-discharge HIV care. The care model draws from other successful programs in Zambia. In ReCharge 2 the investigators now propose to pilot the program and assess feasibility, acceptability, and potential for clinical impact.

Official Title
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Re-engagement at Discharge 2: Improving Post-hospital Outcomes for Adults With HIV in Zambia

Conditions
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HIV/AIDS, Hospitalization, Transitions of Care, Opportunistic Infections

Intervention / Treatment
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* Behavioral: Community Health Worker Post-Discharge Intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 18+ years HIV-positive Hospitalized for at least 1 night at study site Clinically stable and expected to be discharged according to their clinician Objective evidence of suboptimal HIV outcome, defined as HIV viral load above the lower limit of the assay or T-cell cluster of differentiation 4 count <=200. Exclusion Criteria: Unable to provide informed consent No phone Planning to reside outside of Lusaka urban district after discharge

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Health Services Research
Intervention Model: Single Group Assignment
Interventional Model Description: Community health worker follow-up after discharge from hospital
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Community Health Worker Post-Discharge Intervention<br>This group will be offered a community-based visit from a community health worker following hospital discharge. | Behavioral: Community Health Worker Post-Discharge Intervention<br>* Clients will be offered a community-based follow-up from a community health worker after hospital discharge.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Post-Discharge Visits | Proportion of discharged patients who are successfully visited after discharge. | Through three months post-discharge | 
| Comprehensive Post-Discharge Visits | Proportion of discharge follow-up visits by a community health worker that are comprehensive | Through three months post-discharge | 
| Post-Discharge Clinic Visits | Proportion of initial post-discharge visits to the HIV clinic that are attended by the participant's community health worker | Through three months post-discharge | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| HIV viral load suppression | Proportion of clients with suppressed HIV viral load at 6 months post-discharge. | 6 months post-discharge | 
| Mortality | Proportion of clients alive at 6 months post-discharge. | 6 months post-discharge | 
| Retention in HIV care | Retention in HIV care after discharge defined by no gap of >28 days off antiretroviral therapy from discharge date to 6 months post-discharge date | 6 months post-discharge | 
| Antiretroviral therapy clinic visit | Antiretroviral therapy clinic visit within 1 month of discharge | 1 month post-discharge |