The Evaluation of Left Ventricular Systolic Function in Different Types of Ischemic Heart Disease

Study Overview
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Brief Summary
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The study was designed to evaluate the left ventricular longitudinal strain and strain rate assessed by 2D-STI in patients with coronary microvascular dysfunction (CMD) or obstructive coronary artery disease (CAD) , to investigate the effect of different types of ischemic heart disease on the LV systolic function, and to explore the value of LS on the diagnosis of coronary microvascular dysfunction.

Detailed Description
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A total of 175 patients with chest pain, without wall motion abnormality and without significant coronary artery stenosis (<50%) assessed by coronary angiography or coronary computed tomography were enrolled from July 2011 to December 2017. Coronary flow reserve (CFR) of these patients were detected by transthoracic Doppler echocardiography. The patients were divided into coronary microvascular dysfunction group ( CFR≤2.5, n=67) and control group (CFR>2.5, n=108). At the same time, 67 age-matched patients with any major coronary arteries stenosis≥50% and without wall motion abnormality were involved into the obstructive coronary artery disease group. Parameters of global longitudinal strain (LS) and strain rate, subendocardial LS and subepicardial LS were quantified by 2D-STI, the differences of these parameters among three groups were analyzed，correlation analysis、univariate and multivariate analysis and receiver operating characteristic curve were used.

Official Title
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The Evaluation of Left Ventricular Systolic Function in Different Types of Ischemic Heart Disease by Two-dimensional Speckle-tracking Echocardiography

Conditions
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Coronary Microvascular Dysfunction, Obstructive Coronary Heart Disease

Intervention / Treatment
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* Diagnostic Test: Two dimensional speckle tracking imaging


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age from 18-85 years Exclusion Criteria: patients with history of myocardial infarction or abnormal wall motion suggested by conventional echocardiography patients with acute heart failure, chronic heart failure or LVEF values less than 50% patients with congenital heart disease, severe valvular disease, severe bradycardia, high atrioventricular block and atrial fibrillation patients who did not store ultrasound images or whose ultrasound images were unclear patients who had incomplete clinical data

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| coronary microvascular dysfunction group<br> | Diagnostic Test: Two dimensional speckle tracking imaging<br>* lobal longitudinal strain and strain rate, subendocardial LS and subepicardial LS were quantified by two dimensional speckle tracking imaging<br>|
| obstructive coronary artery disease<br> | Diagnostic Test: Two dimensional speckle tracking imaging<br>* lobal longitudinal strain and strain rate, subendocardial LS and subepicardial LS were quantified by two dimensional speckle tracking imaging<br>|
| control group<br> | Diagnostic Test: Two dimensional speckle tracking imaging<br>* lobal longitudinal strain and strain rate, subendocardial LS and subepicardial LS were quantified by two dimensional speckle tracking imaging<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| global longitudinal strain | global longitudinal strain of CMD group and obstructive CAD group | 15/3/2018-30/12/2018 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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two-dimensional speckle tracking imaging, strain, coronary microvascular dysfunction