Use of an Antiemetic to Shorten the Length of Labor in Nulliparous Women

Study Overview
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Brief Summary
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Reducing the length of labor is a highly desirable goal of intrapartum care, both from a perspective of maternal and fetal well-being , and for the providers of the birth services. Avoiding a long , protracted labor entails shorter exposure to pain anxiety and stress and would translate into a major improvement in maternal satisfaction with the child birth experience. The purpose of this study is to determine the effectiveness of metoclopramide for reducing the duration of spontaneous labor among nulliparous women managed according to a standard intrapartum protocol.

Detailed Description
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Women who will fulfill the study inclusion and exclusion criteria and agree to be included in the study will be randomized assigned to receive either an intravenous injection of 10mg metoclopramide (Group 1) or the same volume of placebo, i.e. 0.9% sodium chloride (Group2). Randomization will be achieved using computer generated randomization sequences. Allocation will be in 1:1 ratio. Record of group allocation will be maintained by a resident physician whose responsibility is randomization and drawing up the injection, but has no direct involvement in the intrapartum decision making. After through history and physical examination, each participant will take the selected medication slowly IV over 2 min, the assigned medication will be repeated every two hours for a maximum of three doses. Monitoring of fetal well-being and labor progress with Partographic representation will be performed. Management of labor will be according the labor and delivery standard protocol, if labor dilatation will not progress appropriately, i.e. cervical dilatation rate of <1cm/hour, amniotomy will be performed if membranes are intact. Oxytocin augmentation will be considered after rupture of membranes only if the cervix remains unchanged on two consecutive pelvic examination conducted two hours apart. Oxytocin infusion will start with 5mIU/min and increase by 5mIU/min every 15min to achieve seven contractions in 15 min, the maximal rate of oxytocin being 30Miu/min. The following parameters will be recorded for every patient: Timing of metoclopramide or placebo injections Timing of full dilatation of cervix Duration of first stage of labor Duration of second stage of labor Duration of third stage of labor Mode of delivery Injection to delivery interval Cervical dilatation rate Neonatal condition at birth

Official Title
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Use of an Antiemetic to Shorten the Length of Labor in Nulliparous Women, Exploring a Potential Role of an Old Drug

Conditions
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Prolonged First Stage of Labor

Intervention / Treatment
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* Drug: Metoclopramide
* Drug: Placebo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Primigravida Singleton pregnancy Term gestation i.e. 37- 42 weeks Sure reliable dates Vertex presentation, occipitoanterior position Spontaneous onset of labor Regular uterine contractions at every 5 min ,each lasting for 20 sec Cervical dilatation of 3-5cm With or without rupture of membranes No evidence of maternal or fetal distress Exclusion Criteria: Mal-presentations Mal-positions Multifetal pregnancy Cephalopelvic disproportion history of cervical surgery or injury Hypersensitivity to metoclopramide

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Metoclopramide<br>Intravenous injection of 10mg metoclopramide | Drug: Metoclopramide<br>* Intravenous injection of 10mg metoclopramide, at enrollment, then every 2 hours. Maximum of 3 doses.<br>* Other names: Primperan (Trademark);|
| Placebo Comparator: Placebo<br>Intravenous injection of 0.9% sodium chloride | Drug: Placebo<br>* Intravenous injection of 0.9% sodium chloride, at enrollment, then every 2 hours. Maximum of 3 doses.<br>* Other names: Normal saline;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cervical dilatation rate |  | 6 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Duration of the first stage of labor |  | 6 hours |