Predictors of Response to Treatment for Depression

Study Overview
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Brief Summary
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The current study will examine neurophysiological, specifically event-related potential (ERP), measures of emotional processing as predictors of response to cognitive behavior therapy for adolescent depression.

Detailed Description
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Neurophysiological measures (i.e., event-related potentials) of reward responsiveness and regulation of mood-congruent, sad stimuli will be assessed in a sample of adolescents with depression prior to group cognitive behavior therapy (CBT). CBT will follow the Adolescent Coping with Depression Course, an established 16-session group treatment protocol, and consist of behavioral activation, relaxation skills, cognitive therapy, social skills, problem solving, and relapse prevention. Changes in symptoms will be monitored through biweekly self-report and clinician ratings to examine prediction of change in symptoms across CBT. Baseline individual differences in reward responsiveness and emotion regulation will be evaluated as predictors of change in self-reported symptoms and clinician-rated improvement following CBT.

Official Title
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Neural Predictors of Response to Cognitive Behavioral Therapy for Adolescent Depression

Conditions
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Adolescent Depression, Depression

Intervention / Treatment
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* Behavioral: Cognitive Behavioral Therapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Participants presenting with major depressive or persistent depressive disorder and moderate severity on the Clinical Global Impressions scale. Participants may have comorbid externalizing or anxiety disorders. Participants (and parents of minors) fluent in English. Exclusion Criteria: Youth with history of treatment for substance use disorders. Youth with intellectual or developmental disabilities (e.g., autism spectrum disorders, pervasive developmental disorders). Youth with lifetime schizophrenia, psychosis, or mania. Youth with severe current suicidality. Youth taking antipsychotic medications or mood stabilizers. Youth with recent changes in dosage of antidepressant (adolescents with change in dosage in past 30 days who otherwise meet study criteria will be asked to begin the study once dosage has been stable for 30 days). Parent or child not fluent in English. Youth who are unable to complete study procedures because of visual or hearing impairments. Youth who have recently started outside therapy (past 30 days at time of intake), are engaged in treatment that is determined to be too similar to study therapy (e.g, other CBT groups), or are currently in treatment that is too intensive to allow for participation in study therapy (e.g., partial hospitalization programs)

Ages Eligible for Study
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Minimum Age: 14 Years
Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Active Treatment<br>Group cognitive behavioral therapy (CBT) for 8 weeks. | Behavioral: Cognitive Behavioral Therapy<br>* Cognitive Behavioral Therapy will follow the Adolescent Coping with Depression Course (CWD; Clarke et al., 1999), an established 16-session group treatment protocol, and consist of behavioral activation, relaxation skills, cognitive therapy, social skills, problem solving, and relapse prevention.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Depressive symptoms | Self-reported symptoms on the Mood and Feelings Questionnaire | past 2 weeks | 
| Clinician-rated improvement | Global improvement rating on the Clinical Global Impression scale | 8 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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reward, emotion regulation, electroencephalogram, event-related potentials, cognitive behavior therapy