Uric Acid Levels and Endothelial Functions

Study Overview
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Brief Summary
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Uric acid is a risk factor for coronary artery disease (CED) in postmenopausal women but the association with inflammation and coronary microvascular endothelial dysfunction is not well-defined. The aim of this study was to determine the relationship of serum uric acid, inflammatory markers and CED.

Official Title
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Clinical Follow-up of Patients With Assessment of Endothelial Dysfunction/Coronary Spasm

Conditions
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Coronary Artery Disease

Intervention / Treatment
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* Other: Questionnaire of overall health


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Referred to Mayo Clinic for cardiac catheterization Postmenopausal Exclusion Criteria: History of percutaneous coronary intervention Coronary artery bypass graft surgery Unstable angina pectoris Valvular heart disease Peripheral vascular disease Known congestive heart failure

Ages Eligible for Study
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Minimum Age: 50 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Women With CED<br>All subjects had blood work with included measurement of C-reactive protein, complete blood count with differential, basic chemistry panel, and uric acid level. All subjects completed a standardized questionnaire to assess baseline characteristics. All subjects underwent comprehensive coronary endothelial function assessment. Subjects completed a questionnaire of overall health several years after the index coronary angiogram and endothelial function study. | Other: Questionnaire of overall health<br>* The standardized questionnaire was used to assess occurrence of major adverse cardiovascular events including stroke, re-hospitalization, myocardial infarction or death. Responses were verified by medical record review conducted by an investigator blinded to the results of the standardized questionnaire.<br>|
| Women Without CED<br>All subjects had blood work with included measurement of C-reactive protein, complete blood count with differential, basic chemistry panel, and uric acid level. All subjects completed a standardized questionnaire to assess baseline characteristics. All subjects underwent comprehensive coronary endothelial function assessment. Subjects completed a questionnaire of overall health several years after the index coronary angiogram and endothelial function study. | Other: Questionnaire of overall health<br>* The standardized questionnaire was used to assess occurrence of major adverse cardiovascular events including stroke, re-hospitalization, myocardial infarction or death. Responses were verified by medical record review conducted by an investigator blinded to the results of the standardized questionnaire.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Serum Uric Acid Level |  | Baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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uric acid, microvascular dysfunction, inflammation