Multiple Biomarkers in ICU Sepsis Patients

Study Overview
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Brief Summary
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Acute kidney injury (AKI) is a common condition among sepsis patients in the intensive care unit (ICU) and is associated with high morbidity and mortality. Oxidative stress biomarkers were investigated in panels and were reported to predict renal failure in sepsis patients. Some biomarkers would be able to identify who will recover and not recover better than serum creatinine. Thus, a combining oxidative stress biomarkers are needed to predict the occurrence or progression of AKI in critically ill patients.

Detailed Description
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Acute kidney injury (AKI) is a common condition among sepsis patients in the intensive care unit (ICU) and is associated with high morbidity and mortality. Oxidative stress biomarkers were investigated in panels and were reported to predict renal failure in sepsis patients. Research on AKI has focused on new damage biomarkers for early detection of AKI and worsening of renal function. Some biomarkers would be able to identify who will recover and not recover better than serum creatinine. Thus, a combining functional and damage markers as well as oxidative stress biomarkers are needed to predict the occurrence or progression of AKI in critically ill patients. Therefore, this prospective, observational study will be conducted in Mainland China

Official Title
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Prognostic Value of Early Oxidative Stress Biomarkers in Patients With Sepsis

Conditions
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Sepsis, Severe, Sepsis, Septic Shock, AKI

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: sepsis patients in appropriate age Exclusion Criteria: ever blood transfusion ever CPR（cardiopulmonary resuscitation)

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| high concentration of biomarkers<br>the patients with biomarkers level over the normal max value | |
| low concentration of biomarkers<br>the patients with biomarkers level below the normal max value | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| presence of AKI | Use serum creatinine or urine output（The KDIGO Guidelines 2012) to asess whether AKI happens to the studied subjects within a week after admission to ICU | a week after admission to ICU | 
| Death of the patients | Mortality of the studied patients | 2 weeks after admission to ICU | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Use serum creatinine to assess renal function of the patients | Concetration of serum creatinine | the 1 day when the patients admitted to ICU | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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AKI, Sepsis, Biomarker, renal function, oxidative stress