linjc16/ctgov huggingface dataset:
Advanced MRI Sequences for Radiation Therapy Treatment Planning

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine if it would be helpful to use advanced MRI imaging techniques to take additional views of the tumor target for radiation treatment planning or treatment follow-up MRI.

Detailed Description
-----------------
The results of this research project will be used to establish a standard MRI protocol specific to each tumor or disease site. An MRI protocol is a list of MR image types that are acquired for each disease site. These images are used to generate the patient's treatment plan.

Official Title
-----------------
Investigation on the Utility of Advanced MRI Imaging Methods for Radiation Therapy Treatment Planning

Conditions
-----------------
Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients aged 18 years older of any race or gender with anal canal, brain, breast, cervix, esophagus, gynecology, head and neck, lung, pancreas, primary liver or liver metastases, prostate cancer or sarcoma either undergoing MRI scan for radiation treatment planning or a post treatment MRI Voluntarily signs an IRB approved consent form Exclusion Criteria: Inability to obtain informed consent from the patient or their medical power of attorney Patients who are not undergoing MR for radiation treatment planning Patients who will not have MRI scans after treatment Patients with pacemakers or other non-MRI compatible metallic implants Pregnant women, by self report using a standard MRI questionnaire Patients who will not receive contrast agent as part of their standard MR, will participate only in the non-contrast portion of the study

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 89 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| MRI for treatment planning or follow up<br>MRI for treatment planning for radiation therapy or those who have completed treatment and are receiving follow up care. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of Participants Successfully Contributing MRI Data | We tested these Advanced MR protocols to evaluate which ones would best visualize the target region. This helped us determine the optimum MR SIM protocols for different sites that became clinical standard. | up to 4 weeks from imaging | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Anal canal, Brain, Breast, Cervix, Esophagus, Gynecology, Head and Neck, Lung, Pancreas, Primary liver or liver metastases, Prostate cancer, Sarcoma
Neonatal Pain- and Distress Experiences and Later Pain Behavior of Former Preterm and Critically Ill Newborn Infants

Study Overview
=================
Brief Summary
-----------------
Preterm and critically ill neonates experience many painful manipulations. The aim of the study is to evaluate the influence of these experiences and maternal deprivation on later pain behavior. Using Scoring systems, Prechtl general movements, skin conductance, testing flexor reflex levels with von Frey filaments and measuring salivary cortisol levels the investigators compare pain behavior of preterm (birth weight (BW) < 1500 grams), term neonates with need of ventilation (> 48 hours) with healthy neonates at the time of their first vaccination at the age of 3-4 months. The investigators are also testing flexor reflexes and skin conductance and general movements in regular intervals during the initial hospital stay. The investigators hypothesize that pain behavior is different at the age of 3-4 months in children with many early painful experiences.

Official Title
-----------------
Effect of Neonatal Pain- and Distress Experiences on Later Pain Behaviour of Former Preterm and Critically Ill Newborn Infants

Conditions
-----------------
Pain

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Preterm < 1500 grams BW, critically ill term newborn on ventilation > 48 hours Exclusion Criteria: Asphyxia ICH grade 3 and higher

Ages Eligible for Study
-----------------
Maximum Age: 7 Days

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Preterm (BW < 1500 grams)<br> | |
| Critically ill term newborn<br>ventilation > 48 hours | |
| Healthy term newborn<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Pain behavior
The Effectiveness of Trans-catheter Foam Sclerotherapy of Pelvic and Atypical Lower Limb Varicosities

Study Overview
=================
Brief Summary
-----------------
pelvic congestion is the most recognized consequence of pelvi-perineal venous insufficiency . chronic pelvic pain prevalence is about 26.6 %in egypt. this research is going to evaluate the effectiveness of foam sclerotherapy and to conclude diagnostic and therapeutic algorithm for this problem.

Detailed Description
-----------------
this study includes clinical and imaging and interventional aspects. detailed history and comprehensive examination of the patient. duplex ultrasonography to detect pelvic varices and presence of reflux. renal and left iliac venogram is usually the first step in the evaluation of compressive syndrome. then cannulate the gonadal and internal iliac veins selectively. contrast medium injected , the incompetent gonadal veins are generally dilated and the contrast pools in the pelvis after injection. embolization by injecting afoam sclerosant as distally as possible to occlude the pelvic venous plexus using occlusion balloon proximal. follow up assessment by VAS score and duplex imaging.

Official Title
-----------------
The Effectiveness of Trans-catheter Foam Sclerotherapy of Pelvic and Atypical Lower Limb Varicosities

Conditions
-----------------
Venous Insufficiency

Intervention / Treatment
-----------------
* Procedure: embolotherapy of incompetent gonadal and iliac veins


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: premenopausal women ovarian point tenderness post coital pain atypical lower limb varices Exclusion Criteria: endometriosis diverticulitis fasciitis psychosexual dysfunction

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Interventional Model Description: premenopausal women with dull aching pain with ovarian point tenderness and post coital pain.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Study group<br>perimenopausal women | Procedure: embolotherapy of incompetent gonadal and iliac veins<br>* minimally invasive<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The difference in pain score before and after therapy | validated analogue scoring of pain From 0 to 10 according to symptoms improvement | one year |
Dietary Assessment and Prevalence of Refeeding Syndrome in High-risk TB Patients in Chhattisgarh, India

Study Overview
=================
Brief Summary
-----------------
Severe tuberculosis (TB) leads to wasting and anorexia, increasing risk of the refeeding syndrome (RFS) as defined by current criteria. TB patients have high metabolic rates and require a high calorie diet, with nutritional supplementation programs improving outcomes. BMI inversely correlates with mortality in these patients. Risk of RFS, a life-threatening syndrome associated with initiation of feeding after a period of low intake, has not been studied in this population and it is not known whether severely malnourished TB patients benefit from lower caloric intake. This study aimed to examine the prevalence of RFS in TB inpatients in rural India and correlate this with baseline and inpatient caloric intake.

Official Title
-----------------
Dietary Assessment and Prevalence of Refeeding Syndrome in High-risk TB Patients in Chhattisgarh, India

Conditions
-----------------
Tuberculosis, Refeeding Syndrome, Severe Malnutrition

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: all adult inpatients admitted to the TB ward able to take enteral intake Exclusion Criteria: unable to take enteral intake

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Inpatient caloric intake |  | from date of admission to discharge, up to 100 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of refeeding syndrome |  | from date of admission to discharge, up to 100 weeks |
Machine Learning-based Early Clinical Warning of High-risk Patients

Study Overview
=================
Brief Summary
-----------------
Through the early warning platform for inpatients established by our hospital, the various indicators of patients collected in real time are carried out for automated intelligent evaluation and analysis, early warning of high-risk patients to assess the impact on patient prognosis and the impact on the occurrence of adverse events in inpatients.

Detailed Description
-----------------
Build the early warning system.

Official Title
-----------------
Machine Learning-based Early Clinical Warning of High-risk Patients

Conditions
-----------------
High-risk Patients, Risk Reduction, Machine Learning

Intervention / Treatment
-----------------
* Device: early warning platform


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients who use ECG monitoring Age ≥ 18 years old Understand and sign an informed consent form Exclusion Criteria: Pregnancy or lactation

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Allocation: Non-Randomized
Intervention Model: Sequential Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: AI group<br>patients evaluated by early warning platform | Device: early warning platform<br>* High risk inpatients will be evaluated by early warning platform<br>|
| No Intervention: usual care group<br>patients not evaluated by early warning platform | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 28-day all cause mortality | 28-day all cause mortality | 28 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hospital mortality | Hospital mortality | through study completion, an average of 1 month |
Effect of Treatments in Patients Hospitalized for Severe COVID-19 Pneumonia: a Multicenter Cohort Study

Study Overview
=================
Brief Summary
-----------------
Several treatments have been used in during the Covid-19 pandemic of 2020. Using patients' registries from several hospitals in Paris, the investigators retrospectively analyzed associations between specific treatments, including but not limited to vaccines targeted against SARS-CoV-2, hydroxychloroquine, azithromycin, remdesivir, baricitinib, tocilizumab, sarilumab, lopinavir/ritonavir and oseltamivir; and clinical outcomes including, death and mechanical ventilation.

Detailed Description
-----------------
Several treatments have been used in during the Covid-19 pandemic of 2020. Using patients' registries from several hospitals in Paris, the investigators retrospectively analyzed associations between specific treatments, including but not limited to vaccines targeted against SARS-CoV-2, hydroxychloroquine, azithromycin, remdesivir, baricitinib, tocilizumab, sarilumab, lopinavir/ritonavir and oseltamivir; and clinical outcomes including, death and mechanical ventilation. Other outcomes of interest include: acute kidney injury, encephalopathy, need for intensive care unit transfers.

Official Title
-----------------
Effect of Treatments in Patients Hospitalized for Severe COVID-19 Pneumonia: a Multicenter Cohort Study

Conditions
-----------------
Covid-19, ARDS, Pneumonia

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: admitted for severe Covid-19 pneumonia (i.e. requiring O2-support more than 6L/min with SpO2<96%) Exclusion Criteria: patients who were previously in ICU patients already hospitalized prior to study start date patients in palliative care lack of consent
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Exposed to the treatment<br>Exposure variable will be studied treatment | |
| Not exposer to the treatment (control group)<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Composite of death and mechanical ventilation | Composite of death and mechanical ventilation (i.e. intubation) | 14-days follow-up | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Death | Death | 14-days follow-up | 
| Mechanical ventilation | Enabled by intubation | 14-days follow-up | 
| Composite of death and mechanical ventilation | Composite of death and mechanical ventilation | 28-days follow-up | 
| World Health Organization score | World Health Organization score | 14-days follow-up | 
| World Health Organization score | World Health Organization score | 28-days follow-up |
The Effect of Pregabalin on the Spinal Anesthesia

Study Overview
=================
Brief Summary
-----------------
Pregabalin, an anticonvulsant is widely used for treatment of neuropathic pain. Recently, it was reported that premedication of pregabalin before general anesthesia is effective to reduce postoperative pain. Up to date, there is no study about the effect of premedication of pregabalin on the spinal anesthesia. Therefore, in this study, investigators investigate the effect of premedication of pregabalin on the spinal anesthesia.

Detailed Description
-----------------
In this study, investigators investigate the effect of premedication of pregabaline 150 mg on the spinal anesthesia. Two hours before spinal anesthesia, placebo pill was administered to patients in the group C and pregabalin 150 mg was administered to patients in the group P, respectively. Time for the onset of blockade, cephalad level of analgesia and duration of analgesia were measured.

Official Title
-----------------
The Effect of Pregabalin on the Spinal Anesthesia: Randomized Controlled Placebo Study

Conditions
-----------------
Block

Intervention / Treatment
-----------------
* Drug: Placebo
* Drug: Pregabalin


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients of American Society of Anaesthesiologists Grades I and II Exclusion Criteria: Patients with infection at the puncture site, coagulopathy, having true hypersensitivity to drugs used, diabetes and hypertension, psychiatric and neurological diseases

Ages Eligible for Study
-----------------
Minimum Age: 19 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Group C<br>Oral placebo pill was administered 2 hours before anesthesia | Drug: Placebo<br> <br> |
| Active Comparator: Group P<br>Oral pregabalin 150 mg was administered 2 hours before anesthesia | Drug: Pregabalin<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Duration of spinal anesthesia | Duration of spinal anesthesia was measured 24 after spinal anesthesia | 24 hours after spinal anesthesia | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
pregabalin, spinal anesthesia
Early Aerobic Training Program After Ischemic Stroke

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to examine the feasibility and efficacy of an early supervised aerobic exercise program for patients following a minor ischemic stroke.

Detailed Description
-----------------
The purpose of this study is to examine the feasibility and efficacy of an early supervised aerobic exercise program for patients following a minor ischemic stroke. Patients after a minor ischemic stroke would be randomized within 1-3 weeks of stroke onset to a control group (6 weeks of low intensity stretching and coordination exercises followed by a supervised aerobic training program) or an experimental group (immediate aerobic training program). Patients will be evaluated for measures of ambulation endurance, mobility, gait, functional assessment and clinical follow-up after 6 weeks and again 3 months later.

Conditions
-----------------
Stroke, Cerebrovascular Accident

Intervention / Treatment
-----------------
* Behavioral: Supervised aerobic training


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: minor ischemic stroke Exclusion Criteria: unstable angina severe lung disease severe symptomatic peripheral vascular disease dementia or other severe neurological disease other severe uncontrolled medical problem

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: Supervised aerobic training|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 6 Minute Walk Test at 6 weeks |  |  | 
| Modified Bruce Exercise Test at 6 weeks |  |  | 
| Activity by Ankle accelerometer at 6 weeks |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Recurrent vascular events at 6 weeks |  |  | 
| METS at 6 weeks |  |  | 
| Stair climbing ascend and descend test at 6 weeks |  |  | 
| Four Square Step Test at 6 weeks |  |  | 
| Gait symmetry by SmartStep at 6 weeks |  |  | 
| Walking Impairment Questionnaire at 6 weeks |  |  | 
| Rivermead Mobility Index at 6 weeks |  |  | 
| Similar outcome measures 3 months later |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Exercise, Rehabilitation, Aerobic training
A Multicenter Clinical Trial on Laparoscopic Colorectal Cancer Surgery Compared With Open Surgery

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to verify the 5-year disease free survival (DFS) of resectable colorectal cancer after laparoscopic surgery according to a Chinese Operative Standard was not inferior to open surgery.

Detailed Description
-----------------
Study type：Interventional Study phase：Phase III Objectives of Study：to verify the 5-year DFS of resectable colorectal cancer after laparoscopic surgery according to a Chinese Operative Standard was not inferior to open surgery. Study design：Randomized parallel control

Official Title
-----------------
A Multicenter Randomized Clinical Trial on Laparoscopic Colorectal Cancer Surgery Compared With Open Surgery in China

Conditions
-----------------
Colorectal Cancer

Intervention / Treatment
-----------------
* Procedure: open surgery
* Procedure: laparoscopic surgery


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: informed consent single colorectal adenocarcinoma, located at any segment of the colorectum with lower margin 5cm or more to the dental line cTNM：colon cancer T1-4N1-2M0，rectal cancer T1-3N1-2M0，longest diameter no more than 6cm age less than 80 years old normal blood routine test and hepatic or renal function test no gastrointestinal surgery history or chemotherapy, radiation, No complete obstruction. Exclusion Criteria: severe comorbidity such as heart attack or stroke, malignance in 5 years can not tolerate to general anesthesia, pneumoperitoneum or surgery pregnant or during breast-feeding period attending other clinical trial involving therapy cannot or disagree to attending the clinical trial

Ages Eligible for Study
-----------------
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: open surgery<br>Conventional procedure | Procedure: open surgery<br>* Patients in this arm undergo radical resection of colon cancer in open surgery.Open surgery is a conventional technique for colorectal cancer patients.<br>* Other names: open;|
| Experimental: laparoscopic surgery<br>Minimum invasive procedure | Procedure: laparoscopic surgery<br>* Patients in this arm undergo radical resection of colon cancer in laparoscopic surgery.Laparoscopic surgery is a new and minimum invasive technique for colorectal cancer patients.<br>* Other names: laparoscopic;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 5 years diseases free survival rate |  | five years | 
| 5 years overall survival rate |  | five years |