The China-Anhui Birth Cohort Study (C-ABCS)

Study Overview
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Brief Summary
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The China-Anhui Birth Cohort Study (C-ABCS) was set up to examine the delayed, cumulative and interactive effects of maternal environmental exposures on birth outcomes and children's development. The C-ABCS recruited pregnant women from six major cities of Anhui province, China, between November 2008 and October 2010. A range of data (including demographic, obstetric, occupational, nutritional and psychosocial factors) were collected by both interviews and laboratory tests. In each trimester, women's blood samples were drawn, and pregnancy complications were abstracted from physician's medical records. By the end of 2011, birth outcomes/birth defects were observed/identified by clinicians within 12 months after the delivery of 11 421 singleton live births of six cities and those outcomes among the remaining 2033 live births are still being observed. In addition, 4668 children from Ma'anshan city will be further followed up during the pre-school period till they reach adolescence to obtain the data on familial environmental exposures as well as children's physical, psychological, behavioural and sexual development. The interview data and information on laboratory examinations are available on request from archives in the Anhui Provincial Key Laboratory of Population Health & Aristogenics.

Official Title
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A Prospective Population-based Cohort Study That Recruited 16766 Pregnant Women From Six Major Cities of Anhui Province in China

Conditions
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Environmental Exposures, Other Pregnancy With Abortive Outcome, Birth Defects, Children Development

Intervention / Treatment
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* Other: No intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Having been lived in local city at least 6 months; Establishing maternal card in the hospital for the first time; Gestational week ≤ 16 weeks; Willing to have antenatal checkups and childbirth in the hospital where they establish maternal cards. Exclusion Criteria: Women who have abnormities in speaking and can not complete the survey by themselves; Women with mental disorders; Women who plan to leave local places.

Ages Eligible for Study
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Minimum Age: 17 Years
Maximum Age: 49 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: No intervention|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pregnancy outcomes and birth defects | By clinical diagnosis, including abortion/premature birth/prolonged pregnancy/fetal death/stillbirth/live birth, Low birthweight/macrosomia/small for gestation age/large for gestation age, Structural birth defects and functional birth defects | Up to 12 months of age | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Children's physical development | Including body height/length, body weight, blood pressure, blood lipoid | At ages of 1.5-3 and 4.5-6 years | 
| Psychological and behavioural development | cognition, behaviour and temperament | At ages of 1.5-3 and 4.5-6 years | 
| Family environmental exposure | Eating patterns and parenting style. | At ages of 1.5-3 and 4.5-6 years | 
| Mental health problems | Mental retardation, attention deficit hyperactivity, disorder, autism spectrum disorders. | At ages of 1.5-3 & 4.5-6 years | 
| Sexual development indicators | Secondary sexual characters, Sexual hormones. | At ages of 9-15 years for boys, and 8-14 years for girls | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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birth cohort study, environmental exposures, birth defects, pregnant outcomes, children development