Body Composition Monitoring(BCM) for Determination of the Fluid Status in Patients Undergoing General Anesthesia

Study Overview
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Brief Summary
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The purpose of this study is to evaluate a recently developed device, which measures body composition (i.e. the water content of the body) in the perioperative setting. Specifically the investigators will test the hypothesis, that extracellular water content after surgery correlates to the amount of intraoperative infusion and positive fluid balance. Furthermore the investigators will test, if preoperative evaluation of body water helps to determine intraoperative fluid requirements and to guide fluid administration.

Detailed Description
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Patients undergoing anesthesia and surgery receive intravenous fluids during the procedure. The amount of administered fluid depends on the type of surgery, cardiovascular stability and intraoperative losses like hemorrhage. Fluid overload as well as hypohydration might be detrimental and might adversely effect outcome after surgery. Specifically overhydration results in significant weight gain, tissue edema and increased morbidity. Technically assisted assessment of volume status before surgery may be useful to direct intraoperative fluid administration and to prevent postoperative volume overload. As a prerequisite the investigators will test a recently developed whole-body bioimpedance spectroscopy device to determine the pre-to postoperative fluid distribution. This body composition monitor (BCM, Fresenius Medical Care, Germany) separates between extracellular and intracellular fluid volume non-invasively by applying a frequency sweep from 3-1000 kilohertz through the entire patient via electrodes placed on the wrist and ankle. The investigators will test the hypothesis that the amount of administered fluid correlates with the amount of overhydration measured postoperatively. that preoperative BCM measurements and thus information about the preoperative hydration state might help to guide fluidmanagement and to reduce the amount of over/ hypohydration postoperatively.

Official Title
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Body Composition Monitoring for Determination of the Fluid Status in Patients Undergoing General Anesthesia

Conditions
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Fluid Overload

Intervention / Treatment
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* Device: Body Composition Monitoring


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 18-80 Years Exclusion Criteria: liver, heart, kidney failure, patients with pacemaker

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: standard fluid management<br>postoperative BMC measurements | |
| Active Comparator: body composition monitoring preoperative<br>pre and postoperative BCM measurements | Device: Body Composition Monitoring<br>* Pre- and postoperative measurements of body composition (intracellular and extracellular water content)via bioimpedance spectroscopy<br>* Other names: Fresenius Healthcare Germany;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative overhydration in liter measured by Body Composition Monitor |  | Measurements will be performed immediatley before and after surgery. The expected time frame will thus be 2-4 hours. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Intraoperative Fluid Administration, Body Composition Measurement