Diffusion Tensor Sequences (DTI) for Study of Lumbar Roots by Magnetic Resonance Imaging (MRI)

Study Overview
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Brief Summary
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Diffusion tensor imaging (DTI) is a non-invasive MRI technique offering a functional approach that provides morphological information about the microstructures of the nerve roots. DTI is a widely used neuroimaging technique and is a current topic of research in the field of peripheral nerve imaging. The aim of this work is therefore to improve DTI sequences by specifically evaluating the contribution of the multiband technique in healthy volunteers.

Detailed Description
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For every healthy volunteer will be acquired: a morphological sequence a reference diffusion tensor sequence covering three lumbar stages (reference DTI), a diffusion tensor sequence acquired in multiband technique, covering three lumbar stages (optimized DTI), a diffusion tensor sequence acquired in a multiband technique, covering a lumbar stage, of higher spatial resolution (centred DTI)

Official Title
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Optimisation of Diffusion Tensor Sequences (DTI) for Study of Lumbar Roots by Magnetic Resonance Imaging (MRI) : a Feasibility Study

Conditions
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Radiculopathy Lumbar, MRI, Diffusion Tensor Imaging

Intervention / Treatment
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* Diagnostic Test: Optimisation of DTI sequences


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Person without history of lumbar surgery Person who has previously consented Exclusion Criteria: MRI contraindications (pace maker, cardiac defibrillator,...) Claustrophobia Pregnant woman Person without social security Person with a guardianship Person carrying metallic surgical material (spine, pelvis, abdomen)

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Intervention<br>Healthy volunteers | Diagnostic Test: Optimisation of DTI sequences<br>* Optimisation of DTI sequences in the study of lumbar roots by MRI<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Image quality measured as signal-to-noise ratio and contrast-to-noise ratio | Comparison of the image quality between DTI optimized and DTI of reference. The signal-to-noise ratio is a measure that compares the level of a desired signal to the level of background noise. Mathematically, the signal-to-noise ratio is the quotient of the (mean) signal intensity measured in a region of interest and the standard deviation of the signal intensity in a region outside the anatomy of the object being imaged. The contrast-to-noise ratio is a measure of image quality based on a contrast rather than the raw signal. | Day 0 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fraction of anisotropy and apparent diffusion coefficient | Comparison of fraction of anisotropy, and apparent diffusion coefficient between DTI optimized and DTI of reference. The measurement of fraction of anisotropy, and apparent diffusion coefficient provides robust values for quantifying the degree of microstructural abnormalities of nerves. | Day 0 | 
| Concordance of observed agreement measured by Cohen's kappa coefficient | Evaluation of interobserver accordance for multiband acquisitions (optimized DTI) | Day 0 | 
| Concordance of observed agreement measured by Intra-class correlation coefficient | Evaluation of interobserver accordance for multiband acquisitions (optimized DTI) | Day 0 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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MRI, Radiculopathy Lumbar, Diffusion tensor imaging, Multiband technique