Castleman Disease Collaborative Network Biobank

Study Overview
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Brief Summary
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The purpose of this study is to create a biobank, which collects, stores, and distributes samples of human tissues, blood, and related health information to qualified scientists, in order to help doctors and researchers better understand why Castleman Disease occurs and develop ways to better treat and prevent it.

Detailed Description
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The CDCN proposes to establish a biobank and associated clinical data for Castleman disease. Tissue and fluid (blood and saliva) samples will be collected both prospectively and retrospectively. Blood or saliva samples may also be collected from relatives of Castleman patients. Because of the scarcity of these samples, it will be necessary to make efforts to access all available cases. Many cases will occur at hospitals that do not have an existing relationship with the CDCN and may not have experience with tissue procurement; however, this is the only way to obtain the vast majority of samples. Samples may be used immediately, banked for future use, or further processed into DNA, cell lines, tissue microarrays, etc. The samples will be stored at Precision for Medicine, a biorepository company that specializes in collection, processing, storage and distribution of biospecimens. Only researchers (US or international) who have applied to the CDCN and have been approved by the Biobank Advisory Board will be eligible to access biospecimens and/or data. The Biobank Advisory Board will be comprised of clinicians and scientists with experience in clinical and investigational practices in Castleman Disease.

Official Title
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The Castleman Disease Collaborative Network Biobank: A Collection of Biospecimens and Clinical Data to Facilitate Research

Conditions
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Castleman Disease, Castleman's Disease, Giant Lymph Node Hyperplasia, Angiofollicular Lymph Hyperplasia, Angiofollicular Lymph Node Hyperplasia, Angiofollicular Lymphoid Hyperplasia, GLNH, Hyperplasia, Giant Lymph Node

Intervention / Treatment
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* Other: Sample Collection


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria Potential study participants may be of any age, gender, or ethnicity who have been diagnosed with Castleman disease Exclusion Criteria None
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Castleman Disease Patients<br>Potential study participants may be of any age, gender, or ethnicity who have been diagnosed with Castleman disease. | Other: Sample Collection<br>* Excess blood sample tubes and/or buccal swabs or saliva will have DNA and RNA extracted and serum and plasma separated out to be stored for future research purposes based on the results of this preliminary research.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Samples Collected | Number of samples collected across different subgroups (e.g. blood products, lymph node) | 3 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Biobank, biorepository, Castlebank, Castleman Disease, CD, MCD, iMCD, Castleman, Castleman's Disease, multicentric Castleman's disease, multicentric Castleman disease, Angiofollicular Lymph Hyperplasia