Comparation of CLASS Combined With Phacoemulsification and CLASS Alone in the Treatment of Primary Open Angle Glaucoma

Study Overview
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Brief Summary
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To compare the effect of intraocular pressure control and the incidence of peripheral anterior synechia between CLASS combined with phacoemulsification and CLASS alone in the treatment of primary open-angle glaucoma

Detailed Description
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Group A: CO2 Laser-Assisted Sclerectomy Surgery combined with phacoemulsification; Group B: simple CO2 Laser-Assisted Sclerectomy Surgery. The patients were followed up for 1 year. The incidence of peripheral anterior synechia and Intraocular pressure changes at 1 day, 1 week, 1 month, 2 months, 3 months, 6 months and 12 months were observed and compared between the two groups.

Official Title
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Comparation of CO2 Laser-Assisted Sclerectomy Surgery Combined With Phacoemulsification and CO2 Laser-Assisted Sclerectomy Surgery Alone in the Treatment of Primary Open Angle Glaucoma

Conditions
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Glaucoma, Open-Angle

Intervention / Treatment
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* Procedure: phacoemulsification;


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Primary open-angle glaucoma patients with cataract in our Ophthalmic Center; Topical use of hypotensive drugs in the treatment of poor or intolerable intraocular pressure control; The patients were aged from 50 to 80 years old, regardless of gender; Class operation and phacoemulsification were performed; Patients are able and willing to comply with the research guidance and may complete all visits required by the research; Informed consent has been signed. Exclusion Criteria: Allergic to any perioperative medication in this study; History of ocular trauma; Any previous intraocular surgery; Angle of the chamber was narrow by angle microscopy (Schaffer grade III and below); Patients diagnosed as secondary glaucoma; Optic atrophy caused by other reasons; The serious complications such as posterior capsule rupture and choroidal hemorrhage occurred during the operation; Serious complications of eyes occurred after operation; The patient's history indicated that he had severe dysfunction of heart, lung, liver and kidney; Women in pregnancy, lactation or planned pregnancy; The researchers believe that the patient's condition may put the patient at significant risk, and may confuse the research results.

Ages Eligible for Study
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Minimum Age: 50 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: CLASS+PHACO<br>CO2 Laser-Assisted Sclerectomy Surgery combined with phacoemulsification | Procedure: phacoemulsification;<br>* Group A: class combined with phacoemulsification<br>|
| No Intervention: CLASS<br>CO2 Laser-Assisted Sclerectomy Surgery | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of peripheral anterior synechia | Incidence of peripheral anterior synechia | 1 year | 
| Intraocular pressure | Intraocular pressure | 1 year |