The Relationship Between Morbid Obesity and Carotid Artery Stenosis

Study Overview
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Brief Summary
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The correlation between metabolic syndrome and carotid artery stenosis is well established. The purpose of this study is to evaluate the relationship between morbid obesity and carotid artery stenosis.

Detailed Description
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The investigators hypothesis is that there is a direct relationship between morbid obesity and carotid artery stenosis. The investigators hypothesize that metabolic/Bariatric surgery improves the stenosis in the carotid artery. This is a prospective comparative study on the candidates for metabolic/Bariatric surgery in the bariatric center, Emek Medical Center, Afula, Israel. The investigators will compare the candidate for metabolic surgery with metabolic syndrome risk factors to the ones without metabolic syndrome risk factors. The assessment of the carotid artery will be done by Ultrasound Doppler before surgery and 6, 12 and 24 month post surgery.

Official Title
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The Relationship Between Morbid Obesity and Carotid Artery Stenosis - a Comparative Prospective Study

Conditions
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Carotid Artery Diseases, Morbid Obesity, Metabolic Syndrome

Intervention / Treatment
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* Diagnostic Test: Ultrasound Duplex


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: • Candidates for first bariatric surgery Exclusion Criteria: Smokers or past smokers Patients who are post carotid artery intervention

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Metabolic syndrome risk factors<br>Candidates for bariatric surgery who have metabolic syndrome risk factors will be evaluated by Ultrasound duplex before the bariatric surgery and 6,12 and 24 months post surgery for Intimal-Media Thickness and Carotid artery velocity | Diagnostic Test: Ultrasound Duplex<br>* The two groups will have Ultrasound Duplex before bariatric surgery, and 6,12 and 24 months post surgery<br>|
| No metabolic Syndrome risk factors<br>Candidates for bariatric surgery who lack metabolic syndrome risk factors will be evaluated by Ultrasound duplex before the bariatric surgery and 6,12 and 24 months post surgery for Intimal-Media Thickness and Carotid artery velocity | Diagnostic Test: Ultrasound Duplex<br>* The two groups will have Ultrasound Duplex before bariatric surgery, and 6,12 and 24 months post surgery<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between morbid obesity and carotid artery stenosis | Evaluate the correlation between the two in order to identify high risk patient for carotid stenosis without metabolic syndrome risk factors | 24 months post surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in Intimal -media thickness | To compare the baseline Intimal-media thickness before surgery to the one post-surgery by the use of Ultrasound | Before bariatric surgery, and 6,12,24 months after the surgery | 
| Changes in the carotid artery velocity | To compare the baseline carotid artery velocity before surgery to the one post-surgery by the use of Ultrasound Doppler | Before bariatric surgery, and 6,12,24 months after the surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Morbid Obesity, Carotid Stenosis, Metabolic Syndrome