Microvascular Reactivity of the Gingiva Around Implant Born Crown

Study Overview
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Brief Summary
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Apply LSCI method for follow-up changes in regional blood flow after compression of the gingiva in order to compare the vascular reactivity of the attached gingiva at implant versus at tooth.

Detailed Description
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This study will examine the effects of implantation and peri-implant soft tissue shaping on the circulation and the regeneration processes of the human gingiva. The primary aim is to determine the effect of a short term disruption of the blood flow in the gingiva next to an implant and the contralateral tooth, in order to compare the functionally active collateral circulation in the attached gingiva at these respective regions. Using Laser Speckle Contrast Imaging technique (LSCI), which provides blood perfusion data, the investigators will have the possibility to detect functional alterations in gingival microcirculation during and after a short term compression of the gingiva. The secondary aim is to assess and compare the time course of the restoration of the circulation on the affected areas. Further aims are to observe if the compensation capability of the circulation is influenced by gingival thickness (biotype) and patient's gender.

Official Title
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Comparison of Microvascular Reactivity Assessed by Post-occlusive Reactive Hyperaemia Test in Gingiva at Natural Tooth and at Implant Borne Crown

Conditions
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Dental Implants

Intervention / Treatment
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* Procedure: Post-occlusive reactive hyperemia test (PORH test)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient with single dental implant installed in the front region of the jaw at least 6 months ago. On the contralateral side a natural tooth is located. Exclusion Criteria: systemic disease smoking alcohol abuse pregnancy gingivitis periodontitis

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Implant<br>Post-occlusive reactive hyperaemia test (PORH test) in the gingiva at a dental implant born crown in the front region of the jaw | Procedure: Post-occlusive reactive hyperemia test (PORH test)<br>* Compression is applied on the buccal side of the attached gingiva, perpendicular to the long axis of the natural or implant born crown 2 mm far from the gingival margin.<br>|
| Tooth<br>Post-occlusive reactive hyperaemia test (PORH test) in the gingiva at the contralateral natural tooth | Procedure: Post-occlusive reactive hyperemia test (PORH test)<br>* Compression is applied on the buccal side of the attached gingiva, perpendicular to the long axis of the natural or implant born crown 2 mm far from the gingival margin.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Magnitude of the hyperemia after PORH test | Blood flow changes are measured by LSCI before (baseline), during and after gingiva compression. The scale is an arbitrary unit (0-3000 LSPU); relative changes to the baseline measurement will be calculate. | 5min | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Longevity of the hyperemia after PORH test | Blood flow changes are measured by LSCI before (baseline), during and after gingiva compression. The scale is an arbitrary unit (0-3000 LSPU); relative changes to the baseline measurement will be calculate. | 20min | 
| Size of the hyperemia after PORH test | Blood flow changes are measured by LSCI before (baseline), during and after gingiva compression. LSCI can measure in several cm2 areas and display blood perfusion as color-coded images. | 20 min | 
| Difference in the magnitude and longevity of hyperemia induced by PORH test next to an implant born crown between women and men. | Blood flow changes are measured by LSCI before (baseline), during and after gingiva compression. The scale is an arbitrary unit (0-3000 LSPU); relative changes to the baseline measurement will be calculate. | 20 min | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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periimplant soft tissue, gingiva, human, microcirculation