Long-term Consequences of Admission for Pediatric Intensive Care Before One Year of Age

Study Overview
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Brief Summary
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This study is a retrospective cohort study. The PICU children will include all surviving children who were admitted to the PICU of Copenhagen University Hospital between 1st of January 2002 and 31st of December 2016. A link to a questionnaire including the Strengths-and-Difficulties parental questionnaire evaluating neurodevelopmental- and behavioral impartment as well as question on current impairments and health, will be sent to parents. For the children aged between 11 and 17 years an additional self-rated questionnaire will be provided.

Detailed Description
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This study is a retrospective cohort study. The PICU children will include all surviving children who were admitted to the pediatric intensive care section of the Department of Neonatology of Copenhagen University Hospital between 1st of January 2002 and 31st of December 2016. The Strengths-and-Difficulties parental questionnaire evaluating neurodevelopmental- and behavioral impartment is web-based an hosted on a safe hospital server. The link will be sent to the universat digital post-box that all Danish citizens use for contact to the public authorities. For the children aged between 11 and 17 years an additional self-rated questionnaire will be provided. Furthermore, parents will answer questions on chronic illness, motor and sensory handicap, and special pedagogical support in day care institutions and school.

Official Title
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Long-term Consequences of Admission for Pediatric Intensive Care Before One Year of Age

Conditions
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Neurodevelopmental Disorders

Intervention / Treatment
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* Other: admission to pediatric intensive care with mechanical ventilation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Admitted to the PICU of Copenhagen University Hospital between 1st January 2002 to 31st of December 2016 Age of admission > 28 days, if born > 37 + 0 or have reached the gestational age of > 40 weeks if the child is premature. Needing ≥ 2 days ventilator support during the PICU stay Valid civil registration number Exlusion criteria: - Death before follow-up

Ages Eligible for Study
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Minimum Age: 2 Years
Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Pediatric intensive care<br>Children admitted to a pediatric intensive care unit before one year of age and admitted for to days or more and treated with mechanical ventilation and alive at follow | Other: admission to pediatric intensive care with mechanical ventilation<br>* admission to pediatric intensive care with mechanical ventilation<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Total difficulty score of the SDQ questionnaire | Total difficulty score of the Strengths and Difficulties Questionnaire | 2 to 18 years of age | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of cerebral palsy | cerebral palsy defined as 2 or higher on the GMFCS-scale | 2 to 18 years of age |