linjc16/ctgov huggingface dataset:
Superficial Cervical Plexus Block for Pacemaker Insertion

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to investigate clinical outcomes from two current standard of care pain control procedures performed for patients undergoing pacemaker insertion.

Official Title
-----------------
Superficial Cervical Plexus Block for Pacemaker Insertion

Conditions
-----------------
Pacemaker Insertion, Regional Block, Pain

Intervention / Treatment
-----------------
* Procedure: Superficial Cervical Plexus Block (SCP) block
* Procedure: Local site infiltration


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age 18-100 years old Registered patients at Mayo Clinic in Florida scheduled to undergo primary insertion of pacemaker Exclusion Criteria: Emergency placement of pacemaker Sub-pectoral placement of pacemaker Patients with history of chronic pain Patients with anatomical abnormality or disruption to the pacemaker insertion site or site of block placement Patients with allergy to local anesthetic

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 100 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Superficial Cervical Plexus Block<br> | Procedure: Superficial Cervical Plexus Block (SCP) block<br>* SCP block using 10-15ml of 1% Ropivacaine<br>|
| Active Comparator: Local Infiltration<br> | Procedure: Local site infiltration<br>* Local site infiltration using 2% lidocaine<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To decrease opioid requirements after Pacemaker insertion |  | first 24 hrs post pacemaker insertion |
Non-Invasive Oral Biofilm Characterization

Study Overview
=================
Brief Summary
-----------------
There is a need for toothpastes that more effectively remove oral plaque and prevent re-formation. The objective of this study is to map the development and resolution of clinical gingivitis using conventional clinical examination and imaging data to determine how useful imaging techniques can be for evaluating how well a toothpaste cleans the teeth

Detailed Description
-----------------
The researcher can use imaging techniques to map changes in gingival blood flow during the development and resolution of fully reversible, early clinical gingivitis using standard-of-care clinical indices as gold standard The researcher can use imaging techniques to map inflammatory microstructural changes in the oral mucosa including swelling, vasodilation and edema during the development and resolution of fully reversible, early clinical gingivitis using standard-of-care clinical indices as gold standard

Official Title
-----------------
Non-Invasive Oral Biofilm Characterization

Conditions
-----------------
Gingivitis

Intervention / Treatment
-----------------
* Device: optical measurements


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adult male or female 18-25 years of age Volunteers with gingivitis but no periodontitis Exclusion Criteria: Subjects who must receive dental treatment during the study dates. History of significant adverse effects following use of oral hygiene products such as toothpastes and mouth rinses. Allergy to personal care/consumer products or their ingredients. Individuals who have taken antibiotics in the previous 3 months Individuals who are pregnant or nursing

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 25 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Gingivitis<br>optical measurements | Device: optical measurements<br>* Laser Speckle Imaging, Optical Coherence Tomography and Multiphoton Microscopy<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in gingival perfusion | optical measurements | up to 6 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Gingivitis
The Effects of Preoperatively Chewing Gum on Sore Throat After General Anaesthesia With a Laryngeal Mask

Study Overview
=================
Brief Summary
-----------------
Postoperative sore throat (POST) is an important problem after general anaesthesia. We assessed whether chewing gum preoperatively can reduce the incidence of POST after general anaesthesia administered via a streamlined liner of the pharyngeal airway (SLIPA).

Official Title
-----------------
The Effects of Preoperatively Chewing Gum on Sore Throat After General Anaesthesia With a Laryngeal Mask

Conditions
-----------------
Postoperative Sore Throat

Intervention / Treatment
-----------------
* Drug: chewed mint gum
* Other: swallow twice


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: American Society of Anaesthesiologists (ASA) class I or II 20-65 years body mass index (BMI) scores <30 undergoing elective hysteroscopic surgery - Exclusion Criteria: chronic laryngitis chronic bronchitis asthma gastroesophageal reflux allergies to study drugs recent use of non-steroidal anti-inflammatory drugs (NSAIDs) a history of upper respiratory tract infection in the past one week Mallampati grade>2 a history of steroid therapy. -

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: the control group<br> | Other: swallow twice<br>* asked to swallow twice without any additional treatment.<br>|
| Placebo Comparator: the gum group<br> | Drug: chewed mint gum<br>* In the preoperative waiting area before transferring to the operating room, patients in group G chewed mint gum for 2 minutes and then spit it out.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the incidence of POST scores > 3 | POST was evaluated by the Numerical Rating Scale (NRS), which ranges from 0 to 10 points, with 0 indicating completely painless, 1  3 indicating mild discomfort, 4   6 indicating moderate pain, and 7  10 indicating severe pain. | within 24 hours after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the POST scores | POST was evaluated by the Numerical Rating Scale (NRS), which ranges from 0 to 10 points, with 0 indicating completely painless, 1  3 indicating mild discomfort, 4   6 indicating moderate pain, and 7  10 indicating severe pain. | 2 hours, 6 hours and 24 hours after surgery. |
A Prospective Randomised Controlled Trial of Management of Recurrent Nosebleeds in Children

Study Overview
=================
Brief Summary
-----------------
To determine whether the selective application of a combined treatment regimen of silver nitrate cautery and 4 weeks of Naseptin cream is superior to naseptin treatment alone in the management of recurrent paediatric epistaxis.

Official Title
-----------------
A Prospective Randomised Controlled Trial of Management of Recurrent Nosebleeds in Children: Antiseptic Cream Alone v's Antiseptic Cream With Nasal Cautery

Conditions
-----------------
Epistaxis

Intervention / Treatment
-----------------
* Procedure: Nasal Cautery


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Children aged 1 - 14 History of repeated epistaxis with at least 1 episode in the previous 4 weeks prior to attending the ENT clinic. Presence of prominent vessels on the anterior nasal septum on the side that reportedly bleeds (or on at least one side if bleeding is reported to be bilateral) Exclusion Criteria: No prominent vessels on examination (these children will be randomised but will be prescribed Naseptin alone and followed up in the same way as the children in the trial, for completeness of data) Known bleeding disorders. Allergy to peanuts, neomycin or chlorhexidine Other causes of nose bleeding eg tumour.

Ages Eligible for Study
-----------------
Minimum Age: 1 Year
Maximum Age: 14 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Nasal Cautery|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Paediatric, Epistaxis, Nose bleed, Naseptin
Anatomical and Functional Macular Changes in Retinal Detachment

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate the correlation between morphologic changes in the outer retina and visual function after successful repair of rhegmatogenous retinal detachment with macula off.

Conditions
-----------------
Rhegmatogenous Retinal Detachment

Intervention / Treatment
-----------------
* Device: Measure the outer retina by spectral domain optical coherence tomography (HRA Spectralis; Heidelberg), and microperimetry (OPKO Instruments)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Rhegmatogenous retinal detachment Exclusion Criteria: Epiretinal membrane

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Retinal detachment cohort<br> | Device: Measure the outer retina by spectral domain optical coherence tomography (HRA Spectralis; Heidelberg), and microperimetry (OPKO Instruments)<br>* Measure the thickness of the outer retina by spectral domain optical coherence tomography (HRA Spectralis; Heidelberg)and perform central microperimetry using new OPKO Instruments OCT.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Retina, Rhegmatogenous retinal detachment, Macular detachment, Spectral domain OCT, Microperimetry
Accuracy of Methemoglobin Measurement for Rainbow DCI Sensors

Study Overview
=================
Brief Summary
-----------------
In this study, the level of methemoglobin (HbMet) will be increased in a controlled manner by administering sodium nitrite intravenously in healthy volunteers. The accuracy of a noninvasive HbMet measurement by a DCI pulse oximeter sensor will be assessed by comparison to blood measurements from a laboratory analyzer.

Conditions
-----------------
Healthy

Intervention / Treatment
-----------------
* Device: DCI pulse oximeter sensor


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Subjects must understand and consent to be in the study American Society of Anesthesiology Class I (Healthy subjects without any systemic disease at all). Exclusion Criteria: Subjects who have any systemic disease at all. Subjects who do not understand the study and the risks involved. Current smokers. Subjects who are pregnant.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Test Group<br>All subjects are enrolled into the test group and all subjects receive DCI pulse oximeter sensor. | Device: DCI pulse oximeter sensor<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Accuracy of Sensor by Arms Calculation | Accuracy will be determined by comparing the noninvasive blood methemoglobin measurement of the pulse oximeter to that obtained from a blood sample and calculating the arithmetic root mean square (Arms) error value. | 5 hours |
Absorption and Muscle-stimulating Effect of Hydrolyzed and Minced Beef

Study Overview
=================
Brief Summary
-----------------
To measure the absorption kinetics and postprandial amino acid availability after ingestion of minced beef compared with hydrolyzed beef in young males. Moreover, the basal muscle protein synthesis and the postprandial muscle protein synthetic response to minced beef and hydrolyzed beef ingestion are measured in young males. The postprandial muscle protein synthetic response is measured and compared during the early postprandial period (0-3 hours) after ingestion of the two meat products.

Official Title
-----------------
Absorption and Muscle-stimulating Effect of Hydrolyzed and Minced Beef

Conditions
-----------------
Meat Protein Supplements, Protein Absorption and Amino Acid Availability, Muscle Protein Synthesis

Intervention / Treatment
-----------------
* Dietary Supplement: Minced beef
* Dietary Supplement: Hydrolyzed beef


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy Non-obese (BMI<30) Exclusion Criteria: Chronic medical disease >5 hour of exercise weekly, except light activities such as stretching/gymnastics and bike-riding/walking as transportation

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 30 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Minced beef<br>Minced beef | Dietary Supplement: Minced beef<br>* Cow meat protein supplement<br>|
| Experimental: Hydrolyzed beef<br>Hydrolyzed beef | Dietary Supplement: Hydrolyzed beef<br>* Cow meat protein supplement<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in skeletal muscle protein fractional synthetic rate | The fractional synthetic rate of skeletal muscle proteins (%/h) measured during the overnight fasted state and the postprandial state. | During the postprandial period (0-3 hrs). | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Protein absorption | The change in venous plasma ring-2H5-phenylalanine enrichment after ingestion of meat protein, reflects the protein absorption from the meat protein products. | During the postprandial period (0-3 hrs). | 
| Plasma amino acid concentration | Change in venous plasma amino acid concentration after ingestion of meat protein. | During the postprandial period (0-3 hrs). |
Peripheral and Coronary Endothelial Dysfunction In Type 2diabetic Patients- Role of Metformin

Study Overview
=================
Brief Summary
-----------------
Peripheral and coronary endothelial dysfunction in type 2 diabetic patients may be influenced by therapeutics. Using Radial flow monitoring and myocardial perfusion magnetic resonance imaging, we designed a controlled randomized double blind study to test the hypothesis that endothelial dysfunction will be reversed following 3 months of Metformin administration vs gliclazide. 30 patients will be included.

Official Title
-----------------
The DIAMET Study: Peripheral and Coronary Endothelial Dysfunction in Type 2diabetic Patients- Evaluation of Reversibility Following 3 Months of Metformin Treatment

Conditions
-----------------
Coronary and Peripheral Endothelial Dysfunction

Intervention / Treatment
-----------------
* Drug: Metformin
* Drug: Gliclazide


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 18-70 years old, type 2 diabetes, non significant coronary atherosclerosis on inclusion coronary angiogram (ie no coronary stenosis > 70%), HbA1c<9% Exclusion Criteria: significant coronary stenosis (>70%), lack of informed consent, unstable hypertension, renal failure, contra-indication to metformin or gliclazide, pregnancy, atrial fibrillation, contraindication to MRI, or to adenosine, brachial artery calcifications

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Metformin|nan|
|Drug: Gliclazide|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Flow dependent and independent Brachial artery vasoreactivity assessed using Doppler technology at 3 month vs baseline |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Myocardial perfusion improvement following improved vasoreactivity assessed using myocardial perfusion imaging at 3 month vs baseline |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Diabetes,, coronary endothelial dysfunction,, metformin,, glyclazide,, MRI.
Prediction and Testing of Antigenic Sites of the AIDS Virus, HTLV-III Recognized by T Lymphocytes for the Development of Synthetic Vaccines

Study Overview
=================
Brief Summary
-----------------
Subjects are healthy adult volunteers either at high risk for HIV infection or already known to be seropositive, who will donate blood for in vitro tests of T-cell function and in vitro responses to synthetic peptides corresponding to sequences from HIV proteins.

Detailed Description
-----------------
Subjects are healthy adult volunteers either at high risk for HIV infection or already known to be seropositive, who will donate blood for in vitro tests of T-cell function and in vitro responses to synthetic peptides corresponding to sequences from HIV proteins.

Official Title
-----------------
Prediction and Testing of Antigenic Sites of the AIDS Virus, HTLV-III Recognized by T Lymphocytes for the Development of Synthetic Vaccines

Conditions
-----------------
HIV Infections, Healthy

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria for the at risk group will be a statement from the donor that he is an active homosexual or bisexual. Homosexual donors must not have AIDS.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Blood Donors, Epitopes, HIV
Proprioceptive Training and Low Back Pain

Study Overview
=================
Brief Summary
-----------------
Proprioceptive weighting changes may explain differences in postural control performance. Deficits in proprioception are found in a subgroup of patients with low back pain. The aim of the study is to clarify whether proprioceptive training has a positive effect on proprioceptive postural control in individuals with recurrent low back pain.

Conditions
-----------------
Proprioceptive Training, Low Back Pain

Intervention / Treatment
-----------------
* Other: Proprioceptive training
* Other: Sham proprioceptive training


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria individuals with low back pain: Age: 18-45 years old At least 1 year of low back pain with/without referred pain in buttock/thigh At least 3 episodes of disabling low back pain At least a score of 20% on the Oswestry Disability Index Willingness to sign the informed consent Exclusion Criteria: History of major trauma and/or major orthopedic surgery of the spine, the pelvis or the lower quadrant One of the following conditions: Parkinson, multiple sclerosis, stroke, history of vestibular disorder, respiratory disease, pregnancy Radicular symptoms Not Dutch-speaking Strong opioids Neck pain Smoking history

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Proprioceptive training<br> | Other: Proprioceptive training<br>* 12 weeks<br>|
| Sham Comparator: Sham proprioceptive training<br> | Other: Sham proprioceptive training<br>* Three times daily inspiratory muscle training (2x30 breaths) at an intensity of 10% Pi,max<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Proprioceptive postural control | Center of pressure displacement (force plate) in standing in response to local muscle vibration on ankle and back muscles to specifically detect the role of proprioception in postural control. | 12 weeks |