Quantitative MRI of Bone Marrow Fat Fraction in Patients With Trepanobiopsy

Study Overview
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Brief Summary
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The study is aimed to find correlation between the assessment of cellularity according to trepanobiopsy data and the results of measuring MRI parameters.

Detailed Description
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The ratio of fat to water in the bone marrow depends on the cellularity of the bone marrow. In addition to the water/fat ratio in bone marrow there are also other parameters for quantitative MRI assessment. These include the apparent diffusion coefficient (ACD), the T1 relaxation time, mapping of the macromolecular proton fraction. The undoubted advantage of MRI is its non-invasiveness and the ability to assess any localization of the bone marrow. MRI may become a new non-invasive method for assessing the cellularity of the bone marrow in children with oncohematological diseases.

Official Title
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Clinical Study of the Sensitivity and Specificity of the Quantitative Assessment of Bone Marrow Cellularity by MRI in Comparison With Trepanobiopsies in Patients With Diseases of the Hematopoietic System

Conditions
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Aplastic Anemia, Aplastic Anemia Idiopathic

Intervention / Treatment
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* Diagnostic Test: Bone marrow cellularity by mDixon-quant


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: presence of indications for performing trepanobiopsy: aplastic anemia chronic myeloproliferative disease reactive changes in hematopoiesis Exclusion Criteria: Refusal to sign an informed consent to participate in a clinical trial Presence of contraindications for MRI examination Extremely serious condition of the patient at the time of inclusion in the study.

Ages Eligible for Study
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Minimum Age: 6 Years
Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: Bone marrow cellularity by mDixon-quant|if trepanobiopsy was performed during the diagnosis, then comparison with MRI Bone marrow cellularity by mDixon-quant|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| correlation between Bone marrow cellularity by mDixon-quant and trepanobiopsy. | Determination of bone marrow cellularity before starting therapy for the underlying disease. Cellularity according to trepanobiopsy data is the ratio of stromal and hematopoietic cells to fat cells in the bone marrow. Cellularity according to MRI - the ratio of water and fat in the bone marrow using the mDixom Quant. | Before the start of treatment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| T1 maping | T1 mapping (ms) is a magnetic resonance imaging technique used to calculate the T1 time | Before the start of treatment | 
| apparent diffusion coefficient | value of apparent diffusion coefficient in mm2/s | Before the start of treatment | 
| Percentage of the macromolecular proton fraction (MPF) | Percentage of the macromolecular proton fraction (MPF) | Before the start of treatment | 
| Percentage of the bone marrow fat fraction | Percentage of the bone marrow fat fraction (FF) by spectroscopy | Before the start of treatment | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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children, Quantitative MRI, trepanobiopsy, Aplastic Anemia Idiopathic