Cystic Fibrosis and Fit-to-Fly

Study Overview
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Brief Summary
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Due to the hypobaric hypoxia during air travel, some patients with Cystic Fibrosis (CF) need supplemental oxygen during air travel. The study aims to evaluate if adding exercise desaturation to the pre-flight evaluation will help predict requirements for in-flight supplemental oxygen.

Detailed Description
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According to the British Thoracic Society (BTS) recommendations regarding pre-flight evaluation in patients with pulmonary disease, pre-flight arterial oxygen saturation or lung function tests do not discriminate sufficiently between those who need supplemental oxygen during flights, and those who can do without.Therefore, more extensively use of Hypoxia Altitude Simulation test (HAST) has been advocated. However, this test is not widely available. Previous studies have shown that exercise testing is useful for the prediction of in-flight hypoxemia. The investigators have previously developed a pre-flight algorithm for patients with chronic obstructive pulmonary disease (COPD), based on oxygen saturation measured by pulse oximetry at rest and during exercise (six minute walking test (6MWT)). It remains unknown as to whether these results are applicable to the CF population. The current study aims to validate the pre-flight algorithm for patients with CF. Since a maximum cardiopulmonary exercise test (CPET) is recommended in the routine CF-control, the investigators also aim to evaluate whether the use of CPET predicts in-flight hypoxemia with greater accuracy than 6MWT, and whether CPET may replace HAST.

Official Title
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Exercise Pulse Oximetry and Pre-flight Evaluation of Adult Cystic Fibrosis (CF) Patients

Conditions
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Cystic Fibrosis, Hypoxemia, Lung Diseases

Intervention / Treatment
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* Other: Pre-flight evaluation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adult CF patients (age from 18 years) Signed informed consent Exclusion Criteria: Ongoing exacerbation Unable to fulfill a CPET or 6MWT Long-term oxygen treatment (LTOT) Severe heart disease Language problems that interfere with data collection

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Pre-flight evaluation|All the participants receive the interventions as part of their routine medical care during their annual visit for CF follow-up. Oxygen saturation are measured by pulse oximetry. Exercise testing is performed by 6MWT and CPET. Pre-flight evaluation is performed by HAST.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Does oxygen saturation during exercise predict in-flight hypoxemia in adult patients with CF? | Oxygen saturation is measured by pulse oximetry (SpO2) during exercise and HAST | 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Pre-flight evaluation, Air travel, Pulseoximetry, Exercise desaturation, Hypobaria, Hypoxemia