Computerized Neuropsychology in Idiopathic Normal Pressure Hydrocephalus (INPH)

Study Overview
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Brief Summary
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A computerised neuropsychological test battery to be used as a standardised tool assessing the cognitive domains affected by idiopathic normal pressure hydrocephalus INPH was developed. The aim of this study is to investigate the reliability, validity and feasibility of the battery.

Official Title
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Evaluation of a Computerised Neuropsychological Test Battery for Idiopathic Normal Pressure Hydrocephalus (INPH)

Conditions
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Normal Pressure Hydrocephalus

Intervention / Treatment
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* Device: Computerized neuropsychological test
* Other: Conventional neuropsychological test


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Probable INPH under investigation Healthy elderly Various diseases Exclusion Criteria: (Healthy elderly) medications affecting nervous system (Healthy elderly)heart disease (Healthy elderly)diabetes (Healthy elderly)disease of the nervous system (Healthy elderly)MMSE < 28 (Healthy elderly)vascular risk factors (Two of: 1 hypertension, 2 smoking or 3 hyperlipidemia) (Healthy elderly)serious disease that may shorten life expectancy (Various diseases) Affected motor functions

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Test-retest<br>Forty-four healthy elderly 60-82 years old | Device: Computerized neuropsychological test<br>* Computerized neuropsychological test battery.<br>|
| Validity<br>Twenty six patients with various diseases and various ages | Device: Computerized neuropsychological test<br>* Computerized neuropsychological test battery.<br>Other: Conventional neuropsychological test<br>* Conventional neuropsychological test (paper and pen)<br>|
| Feasibility<br>Twenty seven patients under the preoperative investigation for INPH | Device: Computerized neuropsychological test<br>* Computerized neuropsychological test battery.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Validity | Computerized test battery and equivalent standard neuropsychological test battery is given to the same subject. Correlation between paper and pen and equivalent computerized test is calculated as a validity measure. | Within 24 h | 
| Reliability | The computerized test battery is given to the same subject twice. Correlation between the two tests is calculated as a test-retest reliability measure. | More than 7 days, within 2 months | 
| Feasibility | Patients under the investigation for INPH are given the computerized test battery. Number of patients who manage to complete the test is the feasibility measure. | Within 24 h | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Normal Pressure Hydrocephalus, Neuropsychological Test, Assessment of cognitive disorders/dementia, Neuropsychological assessment