linjc16/ctgov huggingface dataset:
fMRI Study of Brain Neural Network and Plasticity After Stroke

Study Overview
=================
Brief Summary
-----------------
The purposes of this study are to investigate the functional connectivity of motor network in patients of stroke and investigate the mechanism of brain plasticity for recovery after stroke.

Conditions
-----------------
Stroke

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 1st-ever-stroke whose corticospinal tract was injured less than 1 month after stroke onset Exclusion Criteria: Claustrophobia who use cardiac pacemaker intracranial metal uncontrolled hypertension or hypotension

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Brain motor network, Plasticity, functional MRI, Stroke
Biological Variation of Cardiac Biomarkers in Aortic Valve Stenosis

Study Overview
=================
Brief Summary
-----------------
Calcified aortic valve stenosis (CAVS) is a progressive disease and nowadays, the cornerstone in diagnostics and follow-up is echocardiography. Cardiac biomarkers (such as cardiac troponins T and I and NT-pro-BNP) hold promise to fulfil a role in early recognition of complications concerning the aortic valve and decompensation. For this purpose, it is important to assess the normal biological variation (BV) of cardiac biomarkers in CAVS. The assessment of biological variation will contribute to a better understanding of fluctuation of cardiac biomarkers in subjects with stable CAVS. These data will improve monitoring of CAVS using cardiac biomarkers.

Official Title
-----------------
Biological Variation of Cardiac Biomarkers in Aortic Valve Stenosis

Conditions
-----------------
Aortic Valve Stenosis

Intervention / Treatment
-----------------
* Other: No intervention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Clinically stable moderate aortic valve stenosis No evidence of acute cardiovascular disease Exclusion Criteria: Acute myocardial infarction in the last six months Pulmonary embolism in the last six months Hospitalisation for heart failure in the last six months Chronic kidney disease

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Aortic valve stenosis<br>Individuals with clinically stable moderate aortic valve stenosis | Other: No intervention<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cardiac troponin T |  | One year | 
| Cardiac troponin I |  | One year | 
| NT-pro-BNP |  | One year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
cardiac biomarkers
Efficiency of the Imaging Strategy for the Management of Pneumonia

Study Overview
=================
Brief Summary
-----------------
For patients with suspected pneumonia presenting to the emergency room, the imaging strategy most often involves a frontal and lateral chest x-ray despite poor diagnostic input. Indeed, the radiography is not very sensitive and specific for the diagnosis of pneumopathy compared to the scanner. However, the scanner remains the gold standard, the major constraint of which concerns the irradiation to which the patient is exposed. The new scanners allow ultra-low-dose scans with better sensitivity than standard radiography with an equivalent dose of radiation. In addition, the ultra-low-dose scanner helps prevent diagnostic errors and unintended treatments. A low-dose CT scan for suspected pneumonia has been possible in the Strasbourg emergency department since March 2019. The investigators therefore hypothesize that a diagnostic strategy involving the performance of a low dose CT scan in the event of suspicion of pneumopathy in the emergency room makes it possible to improve the adequacy of the diagnosis made by the initial imaging examination and the diagnosis on discharge from hospitalization, to reduce respiratory or hemodynamic complications and to reduce the prescription of antibiotic therapy that is not suitable for the patient. course of the imaging result validated by a panel of emergency physicians and infectious disease specialists based on medical records in accordance with the recommendations.

Official Title
-----------------
Efficiency of the Imaging Strategy for the Management of Pneumonia in the Emergency Department

Conditions
-----------------
Pneumonia

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: Major subject (≥18 years old) Emergency consultant subject with a final diagnosis of pneumonia, diagnostic code J18 and J15 with imaging: standard radiography or low dose scanner from 03/01/2019 to 02/29/2020 Subject not having expressed their opposition, after information, to the reuse of their data for the purposes of this research Exclusion criteria: Subject having expressed opposition to participating in the study Absence of emergency imaging Subject under guardianship or guardianship Subject under safeguard of justice

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Study of the imaging strategy for the management of patients with pneumonia in emergency departments |  | Files analysed retrospectively from March 01, 2019 to February 29, 2020 will be examined] | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Pneumonia, Emergency, Imaging strategy, pneumopathy, Hemodynamic complications, Antibiotic therapy
The Role of Vitamin D Supplementation on Pain in Women With Primary Dysmenorrhea and Hypovitaminosis D

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate the effect of vitamin D supplementation on the pain score of primary dysmenorrhea. Our hypothesis is that by normalizing vitamin D level could help improve pain score of women who have primary dysmenorrhea.

Detailed Description
-----------------
This study is aimed to be conducted in randomised controlled trial, comparing between intervention group and placebo group. We include women with primary dysmenorrhea who also have low vitamin D level in this trial. Our primary outcome is to compare visual analog pain scale between intervention and placebo group after treatment. After randomised and allocated, these women will be given vitamin D 50,000 IU or placebo capsules orally weekly for 8 consecutive weeks. We monitor pain score daily from the cycle before the drugs started until complete 8-week course of the regimen mentioned. Also vitamin D levels will be monitored twice, one before treatment and the other after treatment.

Official Title
-----------------
The Role of Vitamin D Supplementation on Pain in Women With Primary Dysmenorrhea and Hypovitaminosis D: A Randomized, Double-blind, Placebo-Controlled Study

Conditions
-----------------
Hypovitaminosis D

Intervention / Treatment
-----------------
* Drug: Ergocalciferol Capsules
* Drug: Placebo


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Primary dysmenorrhea Hypovitaminosis D Exclusion Criteria: Using calcium, magnesium or phosphorus in the past 3 months Using hormonal contraception or IUD in the past 6 months No smoking or alcohol drinking Chronic underlying diseases Allergic to components in study drugs

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 30 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Randomised controlled study
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Vitamin D<br>Vitamin D 50,000 IU orally weekly for 8 weeks | Drug: Ergocalciferol Capsules<br>* Given to subjects 50,000 IU per week for 8 weeks<br>* Other names: Vitamin D2;|
| Placebo Comparator: Placebo<br>Placebo capsules orally weekly for 8 weeks | Drug: Placebo<br>* Placebo capsules<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Visual analog pain scale | Pain score between intervention and placebo group after treatment | 8 weeks |
Assessment of the Natural Antibody Response to Pneumococcal Surface Proteins During Acute Otitis Media in Children

Study Overview
=================
Brief Summary
-----------------
This clinical study is designed to assess prospectively the sero-responses to various proteins in cases of pneumococcal Acute Otitis Media.

Official Title
-----------------
Assessment of the Natural Antibody Response to Pneumococcal Surface Proteins During Acute Otitis Media in Children

Conditions
-----------------
Acute Otitis Media

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Male and female Jewish and Bedouin children. Patients can be either ambulatory or hospitalized. Presenting with acute otitis media. Tympanocentesis was performed at least in one ear for a clinical indication. Culture of middle ear fluid was obtained. Parents agreeing to participate in the study and to submit their children for follow-up, blood test and nasopharyngeal/oropharyngeal (NP/OP) cultures. Exclusion Criteria: Having another infection that is likely to be caused by S. pneumoniae. Known immunodeficiency. Known previous recent pneumococcal infections (<1 month prior to current visit).

Ages Eligible for Study
-----------------
Minimum Age: 3 Months
Maximum Age: 3 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Control group - culture negative<br>50 children with pneumococcal culture-negative Acute Otitis Media | |
| study group- culture positive<br>50 children with pneumococcal culture-positive Acute Otitis Media | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Serological studies of pneumococcal proteins and their development over time following otitis media infections | The serological studies will study the natural immune response to protective pneumococcal vaccine antigens. | 3 months per individual | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Vaccine pneumococcal natural history Acute otitis media
Initial Positioning of Left Sided Double Lumen Endobronchial Tubes Using Peak Inspiratory Pressures Difference Between Two Lungs

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to investigate a performance of initial positioning of left sided double lumen endobronchial tubes using peak inspiratory pressures difference between two lungs.

Detailed Description
-----------------
If both lungs have relatively equal volumes and the double lumen tube is in a satisfactory position, peak inspiratory pressure between two lungs is similar or equal when each lumen is sequentially clamped while ventilating each lung with the same tidal volume. We are going to investigate a performance of this method by fiberoptic bronchoscopy view and depth of double lumen tube, and compare with an conventional auscultation method.

Official Title
-----------------
Initial Positioning of Left Sided Double Lumen Endobronchial Tubes Using Peak Inspiratory Pressures Difference Between Two Lungs

Conditions
-----------------
Thoracic Surgery

Intervention / Treatment
-----------------
* Procedure: Pressure difference


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: ASA physical status class I, II Use of double lumen tube Normal preoperative pulmonary function study Exclusion Criteria: COPD Restrictive lung disease CAOD Unstable hemodynamic status Peak inspiratory pressure > 30 mm Hg (Two lung ventilation)

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Sequential Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Pressure difference<br>Peak inspiratory pressures difference between two lungs | Procedure: Pressure difference<br>* Peak inspiratory pressures difference between two lungs<br>|
| No Intervention: FOB evaluation<br>FOB evaluation for the optimal position of tubes | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fiberoptic bronchoscopy view | aucsultation under manual ventilation -> fiberopric bronchoscopy view check peak inspiratory pressure difference under mechanical ventilation -> fiberoptic bronchoscopy view check | within 5 min after intubation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| depth of double lumen tube | aucsultation under manual ventilation -> A depth of DLT (incisor) peak inspiratory pressure difference under mechanical ventilation -> A depth of DLT (incisor) | within 5 min after checking fiberopitics |
Gene Expression in Cumulus Cells to Predict Pregnancy

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine the performance of a genetic assay, GemART, in cumulus cells predictive of embryo viability, and pregnancy success in women undergoing in vitro fertilization (IVF). Performance is defined as success rate per embryo transferred, as measured by the implantation rate of embryos transferred.

Official Title
-----------------
The Predictive Value of a Gene Expression Signature in Cumulus Cells Indicative of Embryo Implantation.

Conditions
-----------------
Infertility

Intervention / Treatment
-----------------
* Other: Morphology
* Other: GemART assay


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Aged 21-39 years IVF cycle 1 or 2 BMI <35 Fertilization method: ICSI and/or IVF Day 3 or day 5 embryo transfer Treatment cycle intended for single or double embryo transfer Use own oocytes, not oocyte donor ≥ 3 embryos at final assessment Donor sperm acceptable Willing to comply with protocol and study procedures Exclusion Criteria: Polycystic Ovarian Syndrome Presence of fibroid(s): >4 cm intramural or submucosal fibroids History of chemotherapy or radiation to the abdomen or pelvis Use of donor oocytes Use of reinseminated oocytes Preimplantation genetic diagnosis or preimplantation genetic screening during current IVF cycle Concurrent participation in another clinical study (Male): Surgically removed sperm (Male): <5 million sperm count

Ages Eligible for Study
-----------------
Minimum Age: 21 Years
Maximum Age: 39 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Morphology<br>Embryos selected for transfer will be based on morphology alone. | Other: Morphology<br>* Embryos selected for transfer will be based upon morphology alone.<br>|
| Experimental: GemART assay<br>Embryos selected for transfer will be based upon morphology and GemART assay. | Other: GemART assay<br>* Embryos selected for transfer will be based upon morphology and GemART assay.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical pregnancy rate | Clinical pregnancy, recorded as either positive or negative, will be determined using vaginal ultrasound during post-transfer week 4-9. Clinical Pregnancy rate for embryos selected using the GemART assay in conjunction with morphology will be compared with clinical pregnancy rate for embryos selected using morphology alone. | Recorded at post-transfer week 4-9 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
In vitro fertilization, Assisted reproduction, pregnancy outcome, cumulus cells
Nebulized Colistin for Hospital-Acquired Pneumonia

Study Overview
=================
Brief Summary
-----------------
Nebulized Colistin for Adjunctive Therapy of Hospital-Acquired Pneumonia caused by Gram Negative Bacteria should be more effective than conventional therapy

Detailed Description
-----------------
Randomized Controlled Clinical Trial in hospitalized adult patients with hospital-acquired pneumonia. The patients are allocated to conventional group or nebulized colistin group. The conventional group receives conventional antibiotics whereas the nebulized colistin group receives nebulized colistin in addition to conventional antibiotics. The outcomes are clinical response and microbiological responses.

Official Title
-----------------
Efficacy and Safety of Nebulized Colistin for Adjunctive Therapy of Hospital-Acquired Pneumonia Caused by Gram Negative Bacteria

Conditions
-----------------
Pneumonia

Intervention / Treatment
-----------------
* Drug: nebulized colistin
* Drug: antibiotics


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adult (age>18 years) hospitalized patient with hospital-acquired pneumonia due to Gram negative bacteria Exclusion Criteria: pregnancy lactating woman colistin allergy severe renal impairment epilepsy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: antibiotic<br>conventional antibiotics | Drug: antibiotics<br>* conventional parenteral antibiotics<br>|
| Experimental: colistin group<br>nebulized colistin | Drug: nebulized colistin<br>* nebulized colistin 75 mg every 12 hours<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical response |  | 14 days after Treatment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Microbiological response and safety |  | 14 days after treatment | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Hospital-Acquired Pneumonia, Gram Negative Bacteria
Urdu Version of Parkinson's Disease Questionnaire: Reliability and Validity Study

Study Overview
=================
Brief Summary
-----------------
In the study , the researchers will investigate the reliability and validity of Urdu version Parkinson's Disease Questionnaire in Pakistani population having Parkinsonism

Detailed Description
-----------------
The study is aimed to translate and culturally adapt Parkinson's Disease Questionnaire-39 into Urdu language and to investigate validity and reliability of Parkinson's Disease Questionnaire-39 in Parkinson's diseased patient among Pakistani population.The study will be a cross sectional survey in which non-probability purposive sampling technique will be used to enroll the participants into the study as per criteria. The results of the study will help to establish an understanding of validity and reliability of Urdu version of Parkinson's Disease Questionnaire-39 with quality of life of Parkinson's Disease patients in Pakistani population having Parkinson's Disease. Reliability of the scale will be checked through internal consistency and test-retest methods. Cronbach's alpha value will be used to analyze internal consistency and for analyzing test-retest reliability an intraclass correlation coefficient with 195 patients will be used

Official Title
-----------------
Reliability and Validity of Urdu Version of Parkinson's Disease Questionnaire in Pakistani Parkinson's Population

Conditions
-----------------
Quality of Life

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Idiopathic Parkinson's Disease Minimum age of 40 years Minimum level of 5 years of education A score equal to or greater than 23 on the Mini-Mental State Examination Patient experiencing at least two of the three cardinal symptoms of idiopathic Pairkinson Disease (rigidity, resting tremor, and bradykinesia.) Exclusion Criteria: Patients with non-idiopathic Parkinsonian variants Patients with a history of drug or alcohol abuse in the last two years Patients with unstable medical problems that may place the patient at increased risk or may interfere with the assessment or treatment of Parkinson's Neurological operation on the brain within one year prior to study entry

Ages Eligible for Study
-----------------
Minimum Age: 30 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Parkinson's Disease Questionnaire | The Parkinson's Disease Questionnaire checks the quality of life of patients suffering from Parkinson Disease | 12th Week | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Parkinson's Disease Questionnaire-39, Parkinson's Disease, Reliability, Validity, Urdu Version