-Oleoyl Glycerol is a GPR119 Agonist and Signals GLP-1 Release in Humans.

Study Overview
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Brief Summary
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The purpose of this study is to evaluate the impact of different ligands of GPR 119 (a G protein-coupled receptor in the intestine) on the secretion of the incretin hormones, GLP-1 and GIP.

Detailed Description
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We have found a new ligand for the GPR 119 receptor. This study evaluate the impact of this ligand on the incretion hormone responses, beta cell function and gall bladder function in healthy young men.

Official Title
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G Protein-coupled Receptor in the Intestine (GPR 119) Stimulated GLP-1 Secretion

Conditions
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Type 2 Diabetes

Intervention / Treatment
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* Dietary Supplement: GPR 119 agonist, 2-oleyl glycerol
* Dietary Supplement: Oleic acid
* Dietary Supplement: Vehicle


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy caucasians v- Normal OGTT (75 g of glucose) according to WHO's criteria Normal hemoglobin Informed consent Exclusion Criteria: Liver disease (ALAT> 2x normal level) Nephropathy (s-creatinin >130 microM or albuminuria) Relatives with type 2 diabetes

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 30 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: GPR119 agonist, 2-oleoyl glycerol<br>2-oleoyl glycerol; 2g. and vehicle | Dietary Supplement: GPR 119 agonist, 2-oleyl glycerol<br>* Emulgation, 50 ml. containing 2g 2OG<br>Dietary Supplement: Vehicle<br>* Fifty milliliters of glycerol (Sigma-Aldrich; batch 32296AK, purity 99%) plus 5 ml 96% ethanol<br>|
| Active Comparator: Oleic acid<br>oleic acid; 3.2g and vehicle | Dietary Supplement: Oleic acid<br>* Emulgation, 50 ml. containing 1.54g of oleic acid<br>Dietary Supplement: Vehicle<br>* Fifty milliliters of glycerol (Sigma-Aldrich; batch 32296AK, purity 99%) plus 5 ml 96% ethanol<br>|
| Placebo Comparator: Vehicle<br>5 ml. of glycerol and 5 ml 96% ethanol | Dietary Supplement: Vehicle<br>* Fifty milliliters of glycerol (Sigma-Aldrich; batch 32296AK, purity 99%) plus 5 ml 96% ethanol<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The effect of this newly discovered GPR 119 agonist on gut hormone responses, in particular GLP-1 in response of the different meals administered to the subjects |  | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Glucose homeostasis, gall bladder contraction in response of the different meals administered to the subjects |  | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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GPR 119, GLP-1 secretion, 2-oleoyl-glycerol, Dietary supplementation