linjc16/ctgov huggingface dataset:
Mitochondrial Dysfunction and Oxidative Stress in Chronic Obstructive Pulmonary Disease (COPD) Patients

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to understand the underlying mechanisms of improved exercise tolerance in COPD patients after training program.

Detailed Description
-----------------
Training protocol used is based on recommendations (Nici et al., 2006) and was previously used in our group (Varray et al., 1991; Vallet et al., 1997). A minimum of 20 sessions in 4-6 weeks were proposed. The exercise intensity of exercise corresponds to target heart rate at ventilatory threshold measured during incremental exercise test. Training at this intensity allowed us to individualize effort for each patient.

Official Title
-----------------
Mitochondrial Respiratory Chain and Peripheral Muscle Dysfunction in COPD Patients

Conditions
-----------------
COPD Patients

Intervention / Treatment
-----------------
* Other: Training


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Sedentary mild to severe COPD patients Exclusion Criteria: Neuromuscular disease Chronic heart failure Renal diseases Liver diseases Obesity

Ages Eligible for Study
-----------------
Minimum Age: 50 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Training<br>20 sessions of training | Other: Training<br>* 20 sessions of training<br>* Other names: CT;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cellular effects of exercise training at the ventilatory threshold intensity |  | 6 to 8 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
COPD, exercise tolerance, oxidative stress
Effects of Specific Lipid Fractions-enriched Infant Formulae

Study Overview
=================
Brief Summary
-----------------
This is a multicenter, randomized, double-blind, parallel-group, reference-controlled 4-month pilot safety study to evaluate the effects of specific lipid fractions-enriched infant formulae on growth of infants aged 0-4 months. The study will test the hypothesis that growth of infants fed the specific lipid fractions-enriched infant formulae will be noninferior to growth of infants fed standard infant formula.

Official Title
-----------------
Multicenter, Randomized, Double-blind, Parallel-group, Reference-controlled, Safety Pilot Study to Evaluate the Effects of Specific Lipid Fractions-enriched Infant Formulae in Infants Aged 0-4 Months

Conditions
-----------------
Infant Growth

Intervention / Treatment
-----------------
* Other: Standard infant formula
* Other: Standard infant formula with PL1
* Other: Standard infant formula with PL2


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy newborn infant Infant is ≤14 days old on day of enrollment Gestational age ≥37 weeks (full term infants) Birth weight ≥2500 g and ≤4500 g Singleton birth Having obtained his/her parents'/legal representative's informed consent Exclusion Criteria: Having any significant pre-natal and/or post-natal disease and/or congenital illness or malformation that may affect normal growth. Infant undergoing antibiotic therapy. Re-hospitalization for more than 2 days in the first 14 days of life. Parents not expected to comply with the protocol during the period of study participation. Infants currently participating in another trial

Ages Eligible for Study
-----------------
Minimum Age: 1 Day
Maximum Age: 14 Days

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Standard infant formula<br>Standard infant formula fed ad libitum | Other: Standard infant formula<br> <br> |
| Experimental: Standard infant formula with PL1<br>Standard infant formula enriched with PL1 lipid fraction fed ad libitum | Other: Standard infant formula with PL1<br> <br> |
| Experimental: Standard infant formula with PL2<br>Standard infant formula enriched with PL2 lipid fraction fed ad libitum | Other: Standard infant formula with PL2<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mean weight gain (g/day) |  | Enrollment to age 4 months |
Auditory Training With Speech Related Acoustic Cues Using Psychophysical Testing

Study Overview
=================
Brief Summary
-----------------
In this study, the investigators will evaluate whether auditory training with speech-related acoustic features in psychophysical testing will help CI subjects improve speech recognition. The primary endpoint is the speech recognition measures.

Official Title
-----------------
Auditory Training With Speech Related Acoustic Cues Using Psychophysical Testing

Conditions
-----------------
Deafness

Intervention / Treatment
-----------------
* Behavioral: Auditory training


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Native speakers of English Cochlear Nucleus cochlear implant users or Advanced Bionics users Postlingually deafened Has had device experience for at least one year Can be child or adult at the time of enrollment Exclusion Criteria: None

Ages Eligible for Study
-----------------
Minimum Age: 10 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Cochlear implant users<br>The group will receive auditory training (psychophysical), and will be evaluated for speech recognition to determine the effect of training. | Behavioral: Auditory training<br>* Training with psychophysical tests (amplitude modulation detection on single electrodes) for improving speech recognition<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| speech recognition after training | Subjects will be measured for their baseline speech recognition performance (A) and then measured again for speech recognition after receiving auditory training using the psychophysical methods (B). Finally, the subjects will be measured for speech recognition the third time after the training is withdrawn following a ABA longitudinal design. | starting 12 months after the award and will take up to 3.5 years to complete |
Measuring Symptom Relief After Radiofrequency Ablation of the Thyroid

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to measure the impact of thyroid radiofrequency ablation procedure on patients with thyroid-related symptoms using a modified pre-existing scoring system.

Official Title
-----------------
Quantification of Symptom Relief Following Percutaneous Ablation of the Thyroid

Conditions
-----------------
Thyroid

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: - Undergoing Radiofrequency Ablation (RFA) for symptomatic thyroid nodule(s). Exclusion Criteria: - Decline to participate in research.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in symptoms before and after ablation | Measured using a modified 6-item SYS questionnaire that objectively measures patient symptoms on a scale of 0=none, 1=moderate, 2=severe | Baseline and 1-, 3-, 6-, 12-, 18-, and 24-months following treatment | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Thyroid Radiofrequency Ablation Procedure
Asthma and Intimate Partner Violence

Study Overview
=================
Brief Summary
-----------------
This is a cross-sectional observational study on adult asthmatics evaluating the relationship between asthma control and psychosocial factors to include intimate partner violence, stress, anxiety, depression, post-traumatic stress disorder.

Official Title
-----------------
Asthma and Intimate Partner Violence

Conditions
-----------------
Asthma, Domestic Violence

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosis of asthma as defined as postbronchodilator response of at least 12% and 200 milliliters improvement in forced expiratory volume in 1 second (FEV1) or forced vital capacity and/or evidence of positive airway hyperresponsiveness. Exclusion Criteria: Medical factors that would preclude participation as determined by the investigators. Examples include blindness, mental illness that grossly impairs judgment, or active injury requiring treatment.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 69 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Asthma Control Test | asthma control scored on scale of 0-25 with higher numbers reflecting better control. | last 30 days |
Pathogenesis of Primary Spontaneous Pneumothorax

Study Overview
=================
Brief Summary
-----------------
Primary spontaneous pneumothorax most commonly occurs in young, tall, lean males. The estimated recurrence rate is 23-50% after the first episode and increases to 60% after the second pneumothorax. The pathogenesis of this benign disease remains unclear. Generally, rupture of the emphysematous change or blebs in the apex of the lung is considered as the cause of pneumothorax. The main purpose of this study is to investigate the molecular pathogenesis of blebs formation or emphysematous change of the lung in these young, healthy patients.

Detailed Description
-----------------
Primary spontaneous pneumothorax most commonly occurs in young, tall, lean males. The estimated recurrence rate is 23-50% after the first episode and increases to 60% after the second pneumothorax. The pathogenesis of this benign disease remains unclear. Generally, rupture of the emphysematous change or blebs in the apex of the lung is considered as the cause of pneumothorax. The main purpose of this study is to investigate the molecular pathogenesis of blebs formation or emphysematous change of the lung in these young, healthy patients. The blebs resected from the pneumothorax patients will be used for RNA and protein levels analyses. The adjacent normal lung tissue will be used as a control for comparison.

Official Title
-----------------
Molecular Pathogenesis of Primary Spontaneous Pneumothorax

Conditions
-----------------
Pneumothorax

Intervention / Treatment
-----------------
* Procedure: Thoracoscopic bullectomy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age between 14 and 40 years Spontaneous pneumothorax Underwent bullectomy of the lung Exclusion Criteria: With underlying lung disease

Ages Eligible for Study
-----------------
Minimum Age: 14 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Pneumothorax patients<br>Primary spontaneous pneumothorax patients undergoing thoracoscopic bullectomy | Procedure: Thoracoscopic bullectomy<br>* Thoracoscopic wedge resection of the diseased lung<br>* Other names: Video-assisted thoracic surgery (VATS);|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
pneumothorax, thoracoscopy, pathogenesis, blebs, surgery
Visual Acuity and Optical Coherence Tomography One Year After Peeling of Epiretinal Membranes

Study Overview
=================
Brief Summary
-----------------
Improvement in visual acuity and retinal anatomy one year after surgery is assessed and compared to data preoperative and 3 months after surgery

Detailed Description
-----------------
Improvement in visual acuity and retinal anatomy (documented by optical coherence tomography) one year after surgery is assessed and compared to data preoperative and 3 months after surgery. Aim of the study is to examine possible improvements of surgical outcomes in the period up to the one year follow-up.

Official Title
-----------------
Visual Acuity and Optical Coherence Tomography One Year After Peeling of Epiretinal Membranes

Conditions
-----------------
Epiretinal Membrane

Intervention / Treatment
-----------------
* Other: visual acuity testing
* Device: optical coherence tomography


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: vitrectomy with Membrane Peeling due to an epiretinal membrane Exclusion Criteria: none

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: visual acuity testing|testing of visual ycuity by ETDRS charts|
|Device: optical coherence tomography|optical coherence tomography generates sectional slides of the retinal tomography with light|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| visual acuity | visual acuity testing with EDTRS charts | 3 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| optical coherence tomography | optical coherence tomography generates slides of the retinal anatomy with light | 3 minutes |
The Clinical Effect of Vitamin K Administration in Type 2 Diabetic Patients

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to examine the possible clinical effects associated with vitamin K supplementation on the glycemic control, insulin sensitivity and lipid profile of type II diabetic patients.

Official Title
-----------------
The Clinical Effect of Vitamin K Administration in Type 2 Diabetic Patients

Conditions
-----------------
Diabetes Mellitus, Type 2

Intervention / Treatment
-----------------
* Dietary Supplement: Vitamin K
* Other: Placebo


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adult patients 21-65 years old diagnosed with Type II diabetes. Fasting blood glucose concentration ≥ 126 mg/dL . Normal liver Function tests defined as ALT levels up to 33 U/L for males and up to 25 U/L for females, Albumin levels ≥ 3.5 g/dL, Bilirubin up to 1.1 mg/dL . Normal clotting function defined as defined by INR. Normal kidney function defined as serum creatinine values up to 1.3 mg/dL. Exclusion Criteria: Type I diabetic patients. Use of supplements with potential effect on vitamin K level namely supplements containing vitamin K, co-enzyme Q10 or vitamin E > 400 IU . Patients requiring anti-coagulant therapy including patients with prosthetic valves, mitral tissues, DVT, PE, atrial fibrillation and valvular heart disease. Patient with history of coagulation, MI, stroke and embolization. Pregnant or breast feeding women. Being on hormonal therapy or receiving contraceptive pills. Patients treated with glucocorticoids, thiazide diuretics, and atypical antipsychotics. Patients on cholestyramine, antibiotics and coumarins. Patients on lipid lowering agents. Known intestinal malabsorption syndrome, cholestasis or steatorrhea. Smokers.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Vitamin K 1mg<br> | Dietary Supplement: Vitamin K<br>* 1mg<br>|
| Placebo Comparator: Control<br> | Other: Placebo<br>* Lactose<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Homeostasis model assessment of insulin resistance (HOMA-IR) |  | 24 weeks |
Needle Stick Injuries in Emergency Medical Service Practice

Study Overview
=================
Brief Summary
-----------------
During the pandemic era, medical personnel should wear full protective suits. However, they limit the performance of medical procedures. One of the main questions is whether to use double gloves. The study was based on dying gloves used during resuscitation. The gloves were secured with disposable hermetically sealed pouches and described by one of the EMS team members - each time after resuscitation was completed.

Official Title
-----------------
Should we Use Double Gloves During Procedures With Suspected/Confirmed COVID-19 Patient?

Conditions
-----------------
Cardiac Arrest, Needle Stick, Injuries, Glowe

Intervention / Treatment
-----------------
* Procedure: double gloves


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Give voluntary consent to participate in the study Medical profession (paramedics, nurses, physicians) working in Emergency Medical Service Exclusion Criteria: Not meet the above criteria Wrist or low back diseases

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cardiopulmonary resuscitation<br>The study was based on dying gloves used during resuscitation. The gloves were secured with disposable hermetically sealed pouches and described by one of the EMS team members - each time after resuscitation was completed. | Procedure: double gloves<br>* The study was based on dying gloves used during resuscitation. The gloves were secured with disposable hermetically sealed pouches and described by one of the EMS team members - each time after resuscitation was completed.<br>* Other names: DL;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of visible puncture | visible puncture | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| WLT | Water leak test was used to checking unnoticed gloves damage | 1 day | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
needle stick injuries, SARS-CoV-2, COVID-19, personal protective equipment, paramedic, emergency medical service
Sublingual Tonometry to Assess Tissue Perfusion in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Study Overview
=================
Brief Summary
-----------------
Sublingual positioning of a silicon capillary system is applied. After 15 min, while the individual is in resting position with closed mouth and normal tidal breathing through the nose is performed, the silicon capillary system is connected to a capnometer and CO2 tension is measured. The investigators hypothesis is that this setup offers a non-invasive assessment of ventilatory efficiency with similar accuracy as arterial PCO2.

Detailed Description
-----------------
We have developed a new silicon capillary system for sublingual monitoring of CO2 tension in order to assess tissue perfusion. This set up is non-invasive, cheaper than previous tonometry devices and easier to apply in clinical routine. We have recruited patients with stable COPD and healthy individuals. Sublingual tonometry results were evaluated after 15 min of tidal breathing with a capnometer for CO2 tension. Corresponding end tidal CO2 (PETCO2)and arterial blood gas values (pH, PaCO2, PaCO2) were also investigated.

Official Title
-----------------
A New Method of Sublingual Tonometry to Assess Tissue Perfusion in Patients With COPD and Healthy Individuals

Conditions
-----------------
COPD, Healthy Subjects

Intervention / Treatment
-----------------
* Device: sublingual silicon capillary


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: COPD patients with stable disease Exclusion Criteria: acute exacerbation of COPD
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: COPD patients and healthy individuals<br> | Device: sublingual silicon capillary<br>* Stable patients with COPD and healthy individuals were asked to open their mouth and a small butterfly silicon capillary was placed sublingually. After 15 minutes, while the mouth was closed completely and nose breathing was performed, the capillary system was connected to a capnometer and sublingual tonometric PCO2 was measured. At the same time, PETCO2 was also measured and arterial blood was drawn for pH, PO2 and PCO2 analysis<br>* Other names: sublingual tonometry, tissue perfusion, ventilation;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| sublingual tonometric PCO2 - arterial PCO2 |  | one year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| sublingual tonometric PCO2 - PETCO2 |  | one year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
blood gas analysis, ventilatory insufficiency