Do High Doses of Protein Supplements Affect Serum Lipid Profiles?

Study Overview
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Brief Summary
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Protein supplements are widely used among people going to the gym. The effects of these substances on blood biochemical, hematological, inflammatuary, glucose metabolism markers and lipid profile is not well known. The previous studies on this issue give inconclusive results. So the investigators aimed to investigate this subject and compare the blood tests between subjects using and not using protein supplements.

Detailed Description
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As more people are doing regular exercises, people using protein supplements are also increasing. The effects of these substances on blood lipid profiles, biochemical, hematological parameters, inflammatory and glucose metabolism markers are not well known. So the investigators of this study planned to search the effects of these substances on blood tests. Totally 69 subjects going to the gym for at least three preceding months were included to the study. They were divided into two groups: the ones using protein supplements and the ones who never used these substances. Demographic and clinical characteristics were recorded. Dietician assessed the dietary habits of the subjects. Blood was drawn for the tests mentioned above from all of the subjects. And the results were compared between the two groups.

Official Title
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Do High Doses of Protein Supplements Affect Serum Lipid Profiles?

Conditions
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To Study the Effects of Protein Supplements on Blood Tests

Intervention / Treatment
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* Dietary Supplement: protein supplement


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: - Going to the gym for at least three preceding months Exclusion Criteria: Any kind of acute or chronic illness Abnormality on electrocardiography Body-mass index>30 kg/m2 Use of any kind of drugs Hypertension at the time of recruitment

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Protein supplement group<br>The group of subjects who use protein supplements at least for the preceding three months | Dietary Supplement: protein supplement<br>* Protein supplement usage for at least three preceding months in varied amounts<br>|
| Control group<br>The group of subjects who never used protein supplements | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Serum glucose level | mg/dl | 1 day | 
| Serum insulin level | uU/ml | 1 day | 
| Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) | No unit | 1 day | 
| Serum hemoglobine level | g/dl | 1 day | 
| Serum mean platelet volume | fL | 1 day | 
| Serum platelet level | x10^3/uL | 1 day | 
| Serum creatinine level | mg/dl | 1 day | 
| Serum urea level | mg/dl | 1 day | 
| Serum uric acid level | mg/dl | 1 day | 
| Serum aspartate aminotransferase level | U/L | 1 day | 
| Serum alanine aminotransferase level | U/L | 1 day | 
| Serum gama-glutamile transferase level | U/L | 1 day | 
| Serum sodium level | mmol/L | 1 day | 
| Serum potassium level | mmol/L | 1 day | 
| Serum calcium level | mg/dl | 1 day | 
| Serum magnesium level | mg/dl | 1 day | 
| Serum total cholesterol level | mg/dl | 1 day | 
| Serum high-density lipoprotein level | mg/dl | 1 day | 
| Serum low-density lipoprotein level | mg/dl | 1 day | 
| Serum triglyceride level | mg/dl | 1 day | 
| Serum C-reactive protein level | mg/dl | 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Protein supplement, Serum creatinine, Serum sodium, Glucose metabolism, Lipid profile, C-reactive protein