Comparison of Transfers of Fresh and Thawed Embryos in Patients With Prior Failed Embryo Transfer Cycles

Study Overview
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Brief Summary
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This study seeks to determine if patients with a history of failed fresh embryo transfer(s) will have increased success rates with embryo cryopreservation and subsequent thawed embryo transfer when compared to fresh embryo transfer.

Detailed Description
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Implantation failure remains a significant problem in cycles of in vitro fertilization (IVF). Patients with a history of implantation failure in fresh autologous cycles have been shown have reduced chance of success in subsequent fresh autologous cycles. A potentially frequent cause of implantation failure is reduced endometrial receptivity following ovarian stimulation, perhaps due to the effects of supraphysiologic hormone levels on endometrial development. Therefore, such patients may have a greater chance of success if all of their embryos are cryopreserved for use in a subsequent cycle in which endometrial development can be more carefully controlled, absent the effects of ovarian stimulation. Therefore this study compares success rates in cycles of fresh embryo transfer and cycles with transfer of frozen-thawed embryos.

Official Title
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Comparison of Transfers of Fresh and Thawed Embryos in Patients With Prior Failed Embryo Transfer Cycles

Conditions
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Infertility, Subfertility

Intervention / Treatment
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* Procedure: Embryo cryopreservation
* Procedure: Fresh embryo transfer


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 18 to 40 years Cycle day 3 FSH less than 10 IU/l At least 8 antral follicles At least one previous autologous embryo transfer cycle that did not result in ongoing pregnancy at 10 weeks. Exclusion Criteria: Embryo biopsy Any prior fresh embryo transfer that resulted in live birth

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Control<br>Patients in the control group will undergo conventional IVF cycles with fresh blastocyst transfer. | Procedure: Fresh embryo transfer<br>* Subjects in the Control group will receive fresh embryo transfer.<br>|
| Experimental: Test group<br>Patients in the Test group will have their embryos cryopreserved for transfer in a second cycle. | Procedure: Embryo cryopreservation<br>* Subjects in the Test group will have their embryos cryopreserved for transfer in a subsequent cycle.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ongoing pregnancy with fetal heart motion |  | 10 weeks gestation | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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IVF, blastocyst transfer, endometrium, embryo cryopreservation