Transdiagnostic Cognitive Biomarkers

Study Overview
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Brief Summary
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The overall objective of this study is to determine the feasibility of identifying transdiagnostic biomarkers of cognitive function mediated by neuromodulation of the dorsolateral prefrontal cortex that are translatable across disease groups in order to more accurately phenotype clusters of cognitive dysfunction. Completing behavioral paradigms with electrophysiology and TMS is a challenging frontier. This study focuses on the feasibility of such an endeavor for those with chronic pain or depression as well as healthy controls.

Detailed Description
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This study aims to test the feasibility of procedures aimed at discovering transdiagnostic biomarkers for cognitive impairment in chronic pain and depression. Fifteen healthy control participants and 15 participants from each disease group (chronic pain, depression) will be recruited. Using a task-based fmri, TMS will be targeted for priming of the Left DLPFC. EEG will be used during our behavioral paradigm to compare changes in DLPFC function before and after primed TMS.

Official Title
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Transdiagnostic Cognitive Biomarkers

Conditions
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Depression, Pain

Intervention / Treatment
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* Behavioral: Computer game/task
* Behavioral: Health surveys online


Participation Criteria
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Eligibility Criteria
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Arm 1, healthy controls: Inclusion Criteria: Have access to the online study platform. Exclusion Criteria: under 18, non-English speaking Arm 2: pain and depression: Inclusion Criteria: Pain or depression Exclusion Criteria: pregnant women

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Interventional Model Description: Feasibility study
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Healthy Comparison Group<br>Behavioral tasks and surveys online. | Behavioral: Computer game/task<br>* N-back, COGED, PacMan game, Bandit task, Websurf task.<br>* Other names: Behavioral tasks online and in-person.;Behavioral: Health surveys online<br>* Health surveys to study themes like pain, sleep, depression and anxiety, and PTSD.<br>* Other names: PHQ-9, MASQ, GAD-7;|
| Experimental: Pain/Depression patients from clinic<br>MRI, TMS and EEG, and behavioral tasks and surveys online. | Behavioral: Computer game/task<br>* N-back, COGED, PacMan game, Bandit task, Websurf task.<br>* Other names: Behavioral tasks online and in-person.;Behavioral: Health surveys online<br>* Health surveys to study themes like pain, sleep, depression and anxiety, and PTSD.<br>* Other names: PHQ-9, MASQ, GAD-7;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Feasibility for all aspects of the study | Feasibility; the overall objective of this study is to determine the feasibility of identifying transdiagnostic biomarkers of cognitive function mediated by neuromodulation of the dorsolateral prefrontal cortex that are translatable across disease groups in order to more accurately phenotype clusters of cognitive dysfunction. Completing behavioral paradigms with electrophysiology and TMS is a challenging frontier. This study focuses on the feasibility of such an endeavor for those with chronic pain or depression as well as healthy controls. | 1-7 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Acceptability | Sum total of acceptability rating scale of study procedures. | 1-7 days |