Stool Microbiome, Pathogens, and Infectious Agents Among Olympic and Elite Athletes

Study Overview
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Brief Summary
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This research is being done to investigate fecal microbiome and metabolome as well as serum analytes and single nucleotide polymorphisms in Olympic athletes in comparison with other elite athletes.

Detailed Description
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Olympic athletes, non-Olympic elite athletes, and other active adults may have genetic and metabolic profiles that are unique. These profiles may contribute to the caliber of their athletic performance, and they may provide keys to understanding select genetic and metabolic conditions. Therefore, the specific aims of this project are as follows: Specific Aim 1: Characterize the fecal microbial communities in athletes participating in the summer 2016 games and in athletes not participating in the Olympic games Specific Aim 2: Characterize the fecal microbiome metabolome (untargeted) in athletes participating in the summer 2016 games and in athletes not participating in the Olympic games Specific Aim 3: Characterize selected serum analytes and single nucleotide polymorphisms (SNPs) of elite athletes participating in the Summer 2016 games and in athletes not participating in the Olympic games, via serum and saliva analyses, respectively Specific Aim 4: Retain specimens from Olympic athletes participating in the summer 2016 games and in athletes not participating in the Olympic games for future research Specific Aim 7: Examine for the presence of Zika virus RNA in study participants who exhibit symptoms Stool, urine, and blood specimens will be collected to study the stool metabolome, as well as serum analytes and single nucleotide polymorphisms, and the nature and extent of exposure to pathogens and infectious agents. These will be compared between Olympic athletes and other non-Olympic elite athletes.

Official Title
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TRMC-Bio Molecular Profiling of Gut Microbiome, Microbiome Metabolome, Serum Chemistry, and Metabolism-Associated SNPs in Elite Athletes

Conditions
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Athletic Performance

Intervention / Treatment
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* Other: Biospecimen collection and questionnaires


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Member of the Summer 2016 U.S. Olympic team and/or other elite athlete English speaking Willing to provide informed consent and biospecimens Willing to complete questionnaires regarding normal bowel habits and general health Exclusion Criteria: None

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| U.S. Olympic Team and elite athletes<br>Biospecimens will be collected from and questionnaires will be administered to U.S. Olympic team members and other elite athletes | Other: Biospecimen collection and questionnaires<br>* Biospecimen collection and questionnaires<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Baseline identification of microbial community present in stool |  | Approximately 1 week after collection of stool sample | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Stool microbiome, Stool metabolome, Single nucleotide polymorphisms