Steroid Panel for One-step Diagnosis of Adrenal Diseases

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to develop a one-step diagnostic method for adrenal diseases, Patients with adrenal diseases including non-functioning adrenal adenoma, adrenal Cushing's syndrome, primary aldosteronism, and pheochromocytoma will be recruited. Using mass spectrometry analysis based on a multisteroid panel, serum, urine, saliva, and hair samples of the patients will be analyzed. The diagnostic yield of each and combination of steroids will be evaluated.

Detailed Description
-----------------
Adrenal diseases consist of heterogenous diseases. To differentiate various adrenal diseases, multiple steps of diagnostic tests are needed. In this study, the investigators aimed to develop a one-step diagnostic method to differentiate various adrenal diseases using multisteroid panel. About 400 patients with adrenal diseases including non-functioning adenoma, adrenal Cushing's syndrome, primary aldosteronism, and pheochromocytoma will be recruited. Serum, hair, saliva, and urine samples of the patients will be analyzed using mass spectrometry. Each and combination of multisteroid will be evaluated for diagnosing adrenal diseases.

Official Title
-----------------
Development of New Technology for One-step Diagnosis of Adrenal Diseases Based on Adrenal Hormone Panel

Conditions
-----------------
Adrenal Disease

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients who are diagnosed with adrenal diseases Exclusion Criteria: Taking medications that can affect steroid metabolism Major depression, chronic alcoholism Suspected cancer metastasis to adrenal glands Other acute stress conditions

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diagnostic accuracy of multisteroid panel for differentiating adrenal diseases | Evaluate how accurately the developed multisteroid panel diagnoses adrenal disease by measuring sensitivity (%) and specificity (%) for diagnosis of Cushing's syndrome. Evaluate how accurately the developed multisteroid panel diagnoses adrenal disease by measuring sensitivity (%) and specificity (%) for diagnosis of primary aldosteronism. Evaluate how accurately the developed multisteroid panel diagnoses adrenal disease by measuring sensitivity (%) and specificity (%) for diagnosis of pheochromocytoma. | Within 1 year after subject recruitment when the final diagnosis of adrenal diseases are made | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diagnostic accuracy of each steroid component for differentiating adrenal diseases | Evaluate how accurately each component of the steroid panel differentiate adrenal diseases. Sensitivity (%) and specificity (%) of each steroid measures for adrenal Cushing's syndrome will be calculated. Sensitivity (%) and specificity (%) of each steroid measures for primary aldosteronism will be calculated. Sensitivity (%) and specificity (%) of each steroid measures for pheochromocytoma will be calculated. | Within 1 year after subject recruitment when the final diagnosis of adrenal diseases are made |