Stockholm Myocardial Infarction With Nonobstructive Coronaries Study 3

Study Overview
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Brief Summary
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The present pilot study will investigate the prevalence of CMD in an unselected cohort of patients with the working diagnosis MINOCA and to study if the diagnostic yield can be improved by adding adenosine to the CMR investigation. Patient will be their own controls.

Official Title
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Stockholm Myocardial Infarction With Nonobstructive Coronaries Study 3 - Pilot Study of Prevalence of Coronary Microvascular Dysfunction in Myocardial Infarction With Nonobstructive Coronary Arteries

Conditions
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Myocardial Infarction With Nonobstructive Coronary Arteries

Intervention / Treatment
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* Diagnostic Test: Cardiac magnetic resonance imaging to study coronary microvascular dysfunction


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: a suspected diagnosis of MINOCA or takotsubo syndrome with coronary angiography without diameter stenosis ≥50% age 35-80 years reading and writing proficiency in Swedish Exclusion Criteria: Claustrofobia Arrythmia and/or pacemaker (atrial fibrillation and AV-block I- III) Asthma or severe chronic obstructive lung disease eGFR < 30 ml/min spontaneous coronary artery dissection acute pulmonary embolism acute myocardial infarction type 2 cardiomyopathy other than takotsubo syndrome a previous myocardial infarction due to CAD

Ages Eligible for Study
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Minimum Age: 35 Years
Maximum Age: 79 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Interventional Model Description: Patients will be their own controls
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Patients with MINOCA undergoing CMR<br>Patients will be their own controls | Diagnostic Test: Cardiac magnetic resonance imaging to study coronary microvascular dysfunction<br>* Myocardial perfusion mapping will be investigated after administration of adenosine<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diagnostic yield | To increase the diagnostic yield of CMR imaging in MINOCA as a working diagnosis | Through investigation completion, usually 2 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prevalence of CMD in MINOCA | To determine the proportion of patients with the working diagnosis of MINOCA who have CMD. | Through investigation completion, usually 2 hours | 
| Prevalence of CMD in different final MINOCA diagnoses | To study the proportions of CMD in patients with a CMR imaging diagnosis of myocardial infarction, Takotsubo, respectively myocarditis and compare them with the results from a healthy control group | Through investigation completion, usually 2 hours | 
| Angina pectoris | To investigate the occurrence of angina pectoris before inclusion and after 3 months and relate it to CMD | 3 Months |