Effects of Chest Physiotherapy (CPT) on Lung Clearance Index (LCI) in Non Cystic Fibrosis (CF) Bronchiectasis

Study Overview
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Brief Summary
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This study will investigate the effects of on technique of chest physiotherapy on pulmonary function. Effects of pulmonary function will be measured by the spirometry, body plethysmography and by the multiple breath nitrogen washout technique.

Detailed Description
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This is a before-after intervention study. Spirometry, body plethysmography and then multiple breath nitrogen washout will be measured before the application of chest physiotherapy. The chest physiotherapy technique used will be autogenic drainage during 30 minutes. A resting period of 5 minutes will be given to the participant before the following tests. Spirometry, body plethysmography and then multiple breath nitrogen washout will be measured again, in the same order, after the application of chest physiotherapy.

Official Title
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Short-term Effects of Chest Physiotherapy on Ventilation Inhomogeneity in Non-CF Bronchiectasis

Conditions
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Bronchiectasis

Intervention / Treatment
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* Other: Autogenic drainage


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Non cystic fibrosis bronchiectasis in stable state Exclusion Criteria: Not in stable state Bronchiectasis with severe respiratory morbidities likely to reduce the chest physiotherapy session efficacy (e.g. : severe chronic obstructive pulmonary disease)

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Autogenic drainage<br>The autogenic drainage will be the chest physiotherapy technique used for this study. Autogenic drainage is an airway clearance technique that attempts to obtain the optimal airflow to evacuate the secretions. This technique uses modulation of inspiratory and expiratory airflow at different breathing level within the vital capacity. | Other: Autogenic drainage<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of Lung Clearance Index (LCI) | LCI will me measured before and after the chest physiotherapy session | up to 80 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of Spirometry | Forced expired volume in one second (FEV1) and Forced expired flow at 25-75% of the forced vital capacity (FEF25-75) will be measured before and after the chest physiotherapy session | up to 40 minutes | 
| Sputum weight | Sputum will be collected during the 30 minutes of chest physiotherapy session and 5 minutes immediately after. Sputum weight will be measured and correlated with change of LCI and spirometry values | 35 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Lung Clearance Index, Non cystic fibrosis Bronchiectasis, Multiple Breath Nitrogen Washout