Value of CT-Scan and Oral Gastrografin in the Management of Post Operative Small Bowel Obstruction

Study Overview
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Brief Summary
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Small bowel obstructions are responsible for 2 to 5% of emergency hospital admissions and 20% of all emergency surgical procedures. In 60 to 80% of cases, acute small bowel obstructions are the consequence of intraperitoneal postoperative adhesions. They constitute an extremely frequent pathology, leading to a high rate of hospital admissions and money expense. Management of small bowel obstruction is based on 2 options: either a surgical approach where all patients are operating on, or a conservative treatment in which surgery is proposed in case of failure of medical treatment. The surgical approach leads to operate on an excessive rate of patients while the medical approach increases the risk of increased small bowel resection, morbidity rate or hospitalization duration. In order to improve the management of small bowel obstruction, it seems necessary to better distinguish patients that need an emergency surgical procedure from patients in which medical treatment will be useful. Many studies have been performed to investigate the value of imaging in the management of small bowel obstruction, using abdominal X-ray, oral gastrografin administration or CT-Scan. The aim of this study is to analyse the effect of a systematic performance of imaging investigation on the management of patients presenting with a postoperative small bowel obstruction. All patients suffering from a postoperative small bowel obstruction will be included in this study. They will be randomised in 2 groups. In group S, patients will have CT-Scan and oral water administration while in group SG, Patients will have CT-Scan and oral gastrografin administration The major end point of this study is to analyse whether imaging examination can reduce the need for a surgical approach or the rate of small bowel resection and to determine its influence on fasting time or hospitalization duration

Official Title
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Value of CT-Scan and Oral Gastrografin in the Management of Post Operative Small Bowel Obstruction

Conditions
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Small Bowel Obstruction

Intervention / Treatment
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* Drug: gastrograffin
* Drug: water


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Small bowel obstruction in patients with previous abdominal surgery Exclusion Criteria: Age less than 18 years Early small bowel obstruction (less than 4 weeks following abdominal surgery) Small bowel obstruction in the course of digestive cancer. Hyperthermic small bowel obstruction Small bowel ischemia (fever, peritoneal signs, increased leucocytosis) Pregnancy ( Elevated béta HCG levels) Inflammatory bowel disease Previous abdominal radiotherapy Pneumoperitoneum Colorectal obstruction

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br> | Drug: gastrograffin<br>* ingestion<br>|
| Placebo Comparator: 2<br> | Drug: water<br>* oral water ingestion<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Need for surgical management |  | 2 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sensibility and specificity of gastrografin oral administration |  | 2 months | 
| Sensibility and specificity of CT-Scan. |  | 2 months | 
| Sensibility and specificity of abdominal X-ray. |  | 2 months | 
| Fasting time |  | 2 months | 
| Hospitalization time |  | 2 months | 
| Number of small bowel resection |  | 2 months |