Germ Cell Tumor and Testicular Tumor DNA Registry

Study Overview
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Brief Summary
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This study is being done to create a registry to help us learn more about germ cell tumors (GCT) and other testicular tumors. The registry will include people with these tumors and also relatives and unrelated people without these tumors. This study will help us learn more about the prevention, diagnosis, treatment and outcome of these tumors. Studying relatives of patients and people unrelated to patients with GCT and other testicular tumors will help us understand why some people get these tumors and why some people don't.

Official Title
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Germ Cell Tumor and Testicular Tumor DNA Registry

Conditions
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Germ Cell Tumor, Testicular Tumor

Intervention / Treatment
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* Behavioral: Questionnaires
* Other: sample of blood or saliva


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Case Cohort Must be ≥ 18 years of age AND Must be an English-speaker AND Must have a diagnosis or suspicion of germ cell tumor and/or a testicular mass Family Member Cohort Must be ≥ 18 years of age AND Must be an English-speaker AND Must be a blood relative of the proband. Family members of probands are eligible. These individuals need not have a diagnosis of GCT-TT, as they will be used for segregation analysis of suspected variants found in the proband. Control Cohort Must be ≥ 18 years of age AND Must be an English-speaker AND Must not have a personal history of cancer, with the exception of non-melanoma skin cancer, AND Must not have a family history of germ cell tumor or testicular tumor AND Must not be a blood relative of controls enrolled in this study Exclusion Criteria:

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| A: suspicion of germ cell tumor and/or a testicular mass<br>patients with testicular GCTs and non-GCT testicular tumors, extragonadal male GCTs, and female GCTs, | Behavioral: Questionnaires<br> <br> Other: sample of blood or saliva<br>* A sample of blood or saliva will be obtained for DNA extraction. Approximately 2-4 tubes of blood will be collected or one tablespoon of saliva. If a participant has already provided a DNA sample for another MSKCC IRB approved protocol, they may not need to provide an additional sample.<br>|
| B: family members of Group A<br>relatives of patients with GCTs or testicular tumors | Behavioral: Questionnaires<br> <br> Other: sample of blood or saliva<br>* A sample of blood or saliva will be obtained for DNA extraction. Approximately 2-4 tubes of blood will be collected or one tablespoon of saliva. If a participant has already provided a DNA sample for another MSKCC IRB approved protocol, they may not need to provide an additional sample.<br>|
| C: healthy controls unrelated to Group A or B<br>healthy controls who are unrelated to Groups A or B and do not have a personal history of cancer nor a family history of GCT or non-GCT testicular tumors | Behavioral: Questionnaires<br> <br> Other: sample of blood or saliva<br>* A sample of blood or saliva will be obtained for DNA extraction. Approximately 2-4 tubes of blood will be collected or one tablespoon of saliva. If a participant has already provided a DNA sample for another MSKCC IRB approved protocol, they may not need to provide an additional sample.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| creation of a Germ Cell Tumor and testicular tumor registry | We will collect clinical data including diagnosis date, pathology, family history, and risk factors in patients with GCT-TT. | 5 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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14-016