The Early Rehabilitation Program in Post-LT Pts

Study Overview
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Brief Summary
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The purpose of this study is to determine whether an early rehabilitation program for immediate liver transplant patients is safe and effective in preventing critical care illness and intensive care unit acquired weakness.

Detailed Description
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Patients with liver transplantation (LT) have poor general condition before surgery and require ICU care for a certain period. For those patients, the side effects of ICU care such as intensive care unit-acquired weakness (ICU-AW), critical illness polyneuropathy (CIP) are well known. Therefore, we access the safety and efficacy of early rehabilitation program (ERP) in liver transplant recipients. Patients were retrospectively selected for the Pre-ERP group (2014.05-2014.10) and for the Post-ERP group (2015.10-2016.03). During the period of 6 months, 136 patients and 100 patients underwent LT, and 65, 62 patients were enrolled after exclusion. Forty patients from the each group were compared after propensity score matching (PSM).

Official Title
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The Safety and Efficacy of Early Rehabilitation Program in Immediate Liver Transplant Patients

Conditions
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ICU-acquired Weakness

Intervention / Treatment
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* Behavioral: Early rehabilitation program for liver transplantation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: immediate post liver transplant patients Exclusion Criteria: patients who transferred to sub-ICU within 72 hours re-liver transplantation case wound, mental problem post op bleeding unstable vital

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Pre-ERP<br>A group of patients who underwent liver transplantation surgery before the early rehabilitation program | |
| Experimental: Post-ERP<br>A group of immediate liver transplant patients who had an early rehabilitation program in ICU care | Behavioral: Early rehabilitation program for liver transplantation<br>* Deliver the one of 5-step early rehabilitation program for immediate liver transplant pts on weekday<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| ICU day (days) |  | up to 60 days | 
| ventilator day (days) |  | up to 60 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time to start rehabilitation from ICU admission (days) |  | up to 2 weeks | 
| in-hospital LOS (days) |  | up to 24 weeks | 
| hospital readmission rate after surgery (%) |  | 1 year follow up from the surgery | 
| 1 year mortality rate (%) |  | 1 year follow up from the surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Liver transplantation, rehabilitation, ICU acquired weakness