New Quantitive MRI Parameters in Assessing Kidneys of Autosomal Dominant Polycystic Kidney Disease

Study Overview
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Brief Summary
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The purpose of this study is to establish normal Magnetic Resonance quantitative values (tissues stiffness, Apparent Diffusion Coefficient values and Blood Oxygen Level Determination values for both renal cortex and medullary tissues and total renal blood flow) for young Autosomal Dominant Polycystic Kidney Disease patients with normal renal function, and normal young adult controls without Autosomal Dominant Polycystic Kidney Disease and normal renal function. Hypothesis: Newer Magnetic Resonance quantitative imaging parameters (tissue stiffness, Apparent Diffusion Coefficient, Blood Oxygen Level Determination levels, Magnetization Transfer and renal blood flow) will have different values in young adult ADPKD patients as compared to normal volunteers.

Official Title
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Pilot and Feasibility Study: Evaluation of New Quantitative Magnetic Resonance Imaging Parameters in Assessing the Kidneys of Autosomal Dominant Polycystic Kidney Disease

Conditions
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Autosomal Dominant Polycystic Kidney Disease, Kidney Disease

Participation Criteria
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Eligibility Criteria
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Inclusion criteria ADPKD participants Male and female subjects between 18-30 years of age Diagnosis of ADPKD Glomerular Filtration Rate (GFR) of > or = to 60 mL/min (Chronic Kidney Disease-Epidemiology Collaboration equation) Ability to provide written, informed consent Exclusion criteria for ADPKD participants Clinically significant concomitant systemic disease Subjects with Diabetes Mellitus Urinary protein excretion Abnormal urinalysis suggestive of concomitant glomerular disease Subjects having contraindications to, or interference with MRI assessments Subjects with supine blood pressure higher than 140/90 mm Hg or taking blood pressure medications Inclusion criteria for Normal Volunteers Male and female subjects between 18-30 years of age Glomerular Filtration Rate (GFR) of > or = to 60 mL/min (Chronic Kidney Disease-Epidemiology Collaboration equation) Ability to provide written, informed consent Exclusion criteria for Normal Volunteers Previous personal or family history of kidney disease Clinically significant concomitant systemic disease Subjects with Diabetes Mellitus Urinary protein excretion Abnormal urinalysis suggestive of concomitant glomerular disease Subjects having contraindications to, or interference with MRI assessments Subjects with supine blood pressure higher than 140/90 mm Hg or taking blood pressure medications

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 30 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluate renal tissue stiffness | The renal parenchymal tissue stiffness is measured in kilopascals with magnetic resonance elastography sequence. | baseline | 
| Magnetization transfer ratio | The magnetization transfer ratio of renal tissue is measured with magnetization transfer sequence and expressed as a ratio. | baseline | 
| Diffusion | Diffusion is quantified as apparent diffusion coefficient (x10-3/mm2) in renal tissue is measured with intravoxel incoherent motion imaging (IVIM) sequence and diffusion tensor imaging (DTI). | baseline | 
| Perfusion quantified as blood flow in mL/s. | Perfusion in the renal tissue is measured with arterial spin labeling sequence and phase contrast magnetic resonance angiography. | baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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magnetic resonance imaging parameters, magnetic resonance elastography, autosomal dominant polycystic kidney disease, apparent diffusion coefficient, blood oxygen level determinations, diffusion weighted imaging