Brain Imaging in the Idiopathic REM Sleep Behavior Disorder (ALICE)

Study Overview
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Brief Summary
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Idiopathic rapid eye movement sleep behavior disorder (iRBD) is characterized by nocturnal violence, increased muscle tone during REM sleep and the lack of any other neurological disease. However, iRBD can precede parkinsonism and dementia by several years. The causes of the loss of muscle atonia during REM sleep in these patients are unclear. Using 3 T MRI and neuromelanin- sensitive sequences, the signal intensity was previously found to be reduce in the locus coeruleus/subcoeruleus area of patients with Parkinson's disease and RBD. Here, the investigators aimed at studying the integrity of the locus coeruleus/ subcoeruleus complex with neuromelanin-sensitive imaging in 21 patients with iRBD and compared the results with those from 21 age- and gender-matched healthy volunteers. All subjects will undergo a clinical examination, motor, cognitive, autonomous, psychological, olfactory and color vision tests, and rapid eye movement sleep characterization using video-polysomnography and 3 T magnetic resonance imaging.

Official Title
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3 T Multimodal MRI in Idiopathic RBD

Conditions
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REM Sleep Behavior Disorder, Healthy

Intervention / Treatment
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* Other: Clinical investigations


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: - idiopathic RBD (criteria of the international classification of sleep disorders-3) For healthy controls : no neurologic or psychiatric disorder Exclusion Criteria: Contraindication to MRI Do not speak French

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with idiopathic RBD<br> | Other: Clinical investigations<br>* Clinical examination, motor, cognitive, autonomous, psychological, olfactory and color vision tests, and rapid eye movement sleep characterization using video-polysomnography and 3 T magnetic resonance imaging<br>|
| Healthy volunteers<br> | Other: Clinical investigations<br>* Clinical examination, motor, cognitive, autonomous, psychological, olfactory and color vision tests, and rapid eye movement sleep characterization using video-polysomnography and 3 T magnetic resonance imaging<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Signal in the subcoeruleus/coeruleus complex | Brain imaging signal in the subcoeruleus/coeruleus complex in 3T multimodal MRI, using neuromelanin-sensitive sequence | 24h | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Substantia nigra quantity | size of the substantia nigra | 24h | 
| Quality of Sleep | Measures in videopolysomnography of efficiency of sleep | 24h | 
| Cognition | Cognition status (MoCA test) | 24h | 
| Olfactory function | Olfactory function (sniff test) | 24h | 
| Color vision | Color vision function | 24h |