linjc16/ctgov huggingface dataset:
Biobank Clinical Genetics Maastricht (KG01)

Study Overview
=================
Brief Summary
-----------------
Collection of coded biomaterial and clinical data with patients consent for future research.

Official Title
-----------------
Biobank Clinical Genetics Maastricht

Conditions
-----------------
Genetic Disease

Intervention / Treatment
-----------------
* Genetic: Biobanking of biomaterial for future genetic research.


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: New patients visiting the out patient clinic of the department of Clinical Genetics of the Maastricht University Medical Hospital Withdrawal of body material for genetic diagnostics. Exclusion Criteria: Patient does not understand the Dutch language.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Genetic research in 5 areas.<br>Cardiogenetics; Intellectual Disability, Multiple Congenital Abnormalities and Rare Diseases; Oncogenetics; Dermatogenetics; Reproductive Genetics. | Genetic: Biobanking of biomaterial for future genetic research.<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparing genes to discover unknown functions | The biobanked bio material and medical data can be used for future research to learn more about the function of genes. | Genes will be sequenced and compared, within an expected average of 6 months. |
Limb Ischemic Preconditioning for Prevention of Contrast Media Induced Nephropathy in Diabetic Kidney Patient

Study Overview
=================
Brief Summary
-----------------
Contrast media induced nephropathy (CIN) is considered to be a serious complication in patient who underwent coronary angiogram (CAG). The pathogenesis of CIN does not well understood. The probable one is the contrast media makes the afferent vessel in glomeruli constrict and results in renal shut down. Limb ischemic preconditioning, a procedure that makes muscles become ischemic and adapt themselves to produce some cytokines for signaling the vessel more dilated. After the reperfusion, these cytokines are getting back to systemic circulation and effect the afferent vessel in glomeruli to become more dilated and prevent CIN.

Official Title
-----------------
Limb Ischemic Preconditioning for Prevention of Contrast Media Induced Nephropathy in Diabetic Kidney Patient

Conditions
-----------------
Serum Cystatin C Before and After Coronary Angiogram, Serum Creatinine Before and After Coronary Angiogram

Intervention / Treatment
-----------------
* Procedure: limb ischemic preconditioning


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Documented diabetic kidney disease Elective coronary angiogram Glomerular filtration rate < 60 ml/min by Cockroft-Gault or Modification of Diet in Renal Disease or CKD-EPI Exclusion Criteria: Refuse or reject to inform consented Hemodynamic compromise (Heart failure, need for intraaortic balloon pump) Expose to drug or chemical substances potentially to be a nephrotoxic agent with in 1 mo (Not include preexisting Angiotensin converting enzyme inhibitor or Angiotensin receptor blocker with stable serum creatinine) Documented or suspected of peripheral arterial disease, upper or lower limb Bleeding diathesis Contraindicated for coronary angiogram currently on renal replacement therapy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Sham Comparator: limb ischemia<br> | Procedure: limb ischemic preconditioning<br>* use a simple blood pressure cuff inflate for 5 minutes and deflate for 5 minutes alternately in each arms total = 3 cycle in each arm<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| kidney injury before and after coronary angiogram. |  | 1 year |
Pinloc Versus Hansson Pins in the Treatment of Femoral Neck Fractures.

Study Overview
=================
Brief Summary
-----------------
A prospective randomized study comparing a new implant with three interlocked pins for internal fixation of femoral neck fractures (Hansson Pinloc System, Swemac Linköping, Sweden) versus 2 parallel pins with hooks (Hansson Pins, Swemac Linköping, Sweden).

Detailed Description
-----------------
Patients, who are to be treated with internal fixation due to a femoral neck fracture, will be randomized by the surgeon to Pinloc or Hansson Pins using an on-line randomization system. The patients will be followed up at open visits at 3 months and 1 year. At two years the patients will be contacted by phone and medical records studied in order to detect any fracture complications.

Official Title
-----------------
Pinloc Versus Hansson Pins in the Treatment of Femoral Neck Fractures: A Prospective Randomized Study of 500 Patients

Conditions
-----------------
Femoral Neck Fractures

Intervention / Treatment
-----------------
* Device: Pinloc
* Device: Hansson Pins (LIH)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Femoral neck fractures where the preferred treatment is internal fixation. Exclusion Criteria: Unwilling to participate.

Ages Eligible for Study
-----------------
Minimum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Pinloc<br>Plate and 3 interlocked pins. A new device for fixation of femoral neck fractures. | Device: Pinloc<br>* Internal fixation device<br>|
| Active Comparator: LIH (Hansson pins)<br>2 pins. An established method for fixation of femoral neck fractures. | Device: Hansson Pins (LIH)<br>* Internal fixation device<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Failure of fracture treatment | Failure is defined as non-union or avascular necrosis. | Within 2 years postoperatively | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Timed-up and go test | Stand up, walk 3 meters, turn around and sit down | At 3 months and 1 year postoperatively | 
| WOMAC (An established hip score) | An established hip score | At 3 months and 1 year postoperatively | 
| Quality of life (EQ-5D) | EQ-5D | At 3 months and 1 year postoperatively | 
| Pain (Visual analogue scale) | Visual analogue scale (VAS): At rest and during activity | At 3 months and 1 year postoperatively |
Effect of Neck Extension on Intraocular Pressure in Patients Undergoing Palatoplasty

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to investigate the change in intraocular pressure according to the neck extension during palatoplasty in pediatric patients.

Official Title
-----------------
Effect of Neck Extension on Intraocular Pressure in Patients Undergoing Palatoplasty

Conditions
-----------------
Cleft Palate

Intervention / Treatment
-----------------
* Other: Position


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients who have undergone a palatoplasty with cleft palate and who are 6 months or older and under 24 months Patients with ASA class 1-2 Patients who agree to voluntarily participate in this study Exclusion Criteria: Patients who refused to participate in clinical studies History of diagnosis of neurologic or ophthalmic disease History of neurosurgery or ophthalmic surgery

Ages Eligible for Study
-----------------
Minimum Age: 6 Months
Maximum Age: 24 Months

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Position|Neck extension|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Intraocular pressure after neck extension | Intraocular pressure after neck extension during palatoplasty | at 5 minutes after the position change (neck extension) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Intraocular pressure 10 minutes after anesthetic induction | Intraocular pressure 10 minutes after anesthetic induction during palatoplasty | at 10 minutes after anesthetic induction (supine position) | 
| Intraocular pressure at end of surgery | Intraocular pressure at end of surgery with neck extension | immmediately after skin closure (neck extension) | 
| Intraocular pressure 5 minutes after supine position | Intraocular pressure 5 minutes after supine position | at 5 minutes after the position change to the supine position (after the end of the surgery) |
Gas Supply, Demand and Middle Ear Gas Balance: Specific Aim 3c

Study Overview
=================
Brief Summary
-----------------
This study will determine if gas can pass between the environment and the middle ear by way of the eardrum. This route of gas exchange was observed in animals but has not been studied in humans. If gas exchange across the eardrum is documented and the rate is sufficiently high, this can help explain certain past observations such as why middle ear pressure does not change very much in some children and adults when they have a cold or flu. The investigators also expect that the rate of gas exchange across the eardrum will depend on whether or not the eardrum has scarred or abnormally thin regions.

Detailed Description
-----------------
Middle-ear (ME) pressure is a measure of the number of contained gas moles, and processes that addd or remove gas moles from the relatively fixed volume ME cavity change its pressure. Experimental results from animal studies document significant gas exchange across the tympanic membrane and if confirmed for humans may explain some of the paradoxical findings for children with poor Eustachian tube function such as the preservation of an aerated ME when the normal routes of gas supply are disrupted. This study measures the rates of reactive and inert gas exchange across the adult tympanic membrane with and without structural abnormalities and determines if these transfers are purely diffusive phenomena. The resulting data will be used to develop species-specific rate-constants that will be used as parameters in modeling ME pressure regulation.

Official Title
-----------------
Gas Supply, Demand and Middle Ear Gas Balance: Specific Aim 3c

Conditions
-----------------
Healthy

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 18-50 years old at least one intact and effusion-free middle ear Exclusion Criteria: bilateral otitis media unable to remain relaxed and quiet for up to 2 hours

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>Normal tympanic membrane | |
| 2<br>tympanosclerosis | |
| 3<br>dimeric (atrophic) | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
otitis, gas diffusion, Eustachian tube, tympanic membrane
Evaluation of Cardiac Affections in Patients With Mucopolysaccharidosis (MPS) in Assuit University Children Hospital (AUCH)

Study Overview
=================
Brief Summary
-----------------
This study aims to evaluate the different cardiac changes in the various types of MPS disorder and define the outcome of these cardiac abnormalities in those patients admitted to assuit University Children Hospital

Detailed Description
-----------------
The mucopolysaccharidoses (MPSs) are inherited lysosomal storage disorders caused by the absence of functional enzymes that contribute to the degradation of glycosaminoglycans (GAGs). The progressive systemic deposition of GAGs results in multi-organ system dysfunction that varies with the particular GAG deposited and the specific enzyme mutation(s) present. Cardiac involvement has been reported in all MPS syndromes and is a common and early feature, particularly for those with MPS I, II, and VI. Cardiac valve thickening, dysfunction (more severe for left-sided than for right-sided valves), and hypertrophy are commonly present; conduction abnormalities, coronary artery and other vascular involvement may also occur. Cardiac disease emerges silently and contributes significantly to early mortality. The clinical examination of individuals with MPS is often difficult due to physical and, sometimes, intellectual patient limitations. The absence of precordial murmurs does not exclude the presence of cardiac disease. Echocardiography and electrocardiography are key diagnostic techniques for evaluation of valves, ventricular dimensions and function.

Official Title
-----------------
Evaluation of Cardiac Affections in Patients With Mucopolysaccharidosis (MPS) in Assuit University Children Hospital (AUCH)

Conditions
-----------------
Mucopolysaccharidoses

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: - All the patients at any age up to 18 years with any type of MPS confirmed by the enzymatic assay Exclusion Criteria: any patient other than MPS

Ages Eligible for Study
-----------------
Minimum Age: 1 Day
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| children with MPS<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of Cardiac affection in patients with MPS | cardiac affection in MPS patients | on enrollment |
MR Colonography With Fecal Tagging. Barium vs. BariumFerumoxsil

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine whether Barium or BariumFerumoxsil is better for fecal tagging in MR colonography. Patients referred to colonoscopy are offered MR colonography before colonoscopy. Two days before colonography, patients ingest either a contrast agent A (200 ml Barium sulphate solution 1g/ml)) four times a day or a 200 ml contrast agent B (Barium sulfate(25%) and Ferumoxil(75%)) four times a day, which will render fecal masses invisible on the following MR colonography. The patients are randomised to either contrast agent A or B. The examinations are evaluated by two independent blinded readers, who will rate the tagging quality of the contrast agents. The quality of tagging will be rated by a Visual Analog Scale (VAS) and Relative contrast (ReCon = Iwall - Ilumen/ Iwall + Ilumen).

Official Title
-----------------
MR Colonography With Fecal Tagging. Barium vs. BariumFerumoxsil

Conditions
-----------------
Colorectal Cancer, Polyps

Intervention / Treatment
-----------------
* Procedure: MR colonography with fecal tagging


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Suspicion of colorectal polyps or cancer Referred for colonoscopy Exclusion Criteria: Suspicion of IBD Pacemaker Metal in the body Claustrophobia Pregnancy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: MR colonography with fecal tagging|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quality of fecal tagging agent |  |  | 
| Sensitivity of VAS score vs. ReCon score |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
colorectal polyps, colorectal cancer, Virtual colonoscopy, Fecal tagging, MR colonography
AS OCT Evaluation for Perforated Punctual Plugs

Study Overview
=================
Brief Summary
-----------------
Evaluation of the perforated punctal plugs after implantation in cases of punctal stenosis regarding position and patency in the early postoperative period (during the first operative weak)

Detailed Description
-----------------
Prospective non randomized case series study included 50 eyes. The study is conducted on patients attending to the oculoplastic unit of ophthalmology department of Minia university hospital. Informed consents were obtained from the participants in this study. The study was adherent to the tenets of declaration of Heleniski. Anterior segment optical coherence tomography(AS-OCT) was performed for the included patients after perforated plug implantation (during the first operative weak)

Official Title
-----------------
Evaluation of Implanted Perforated Lacrimal Punctal Plugs Using Anterior Segment Optical Coherence Tomography.

Conditions
-----------------
Punctal Stenosis

Intervention / Treatment
-----------------
* Diagnostic Test: Anterior segment optical coherent tomography


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with punctal stenosis who will be treated by implantation of perorated punctal plugs Exclusion Criteria: Patients who are not willing to participate in the study
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: Anterior segment optical coherent tomography|Examination of the implanted perforated lacrimal plugs using anterior segment optical coherent tomography|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluation of the fitting of implanted perforated lacrimal plugs | Either plug is in place or rotated | first week post-operatively | 
| Evaluation of the patency of the plugs | Either plug is patent or occluded | first week post-operatively | 
| Evaluation any contents within the plugs | Blood/ Tears/ Debris | first week post-operatively | 
| Evaluation of the lower tear film height | measuring the tear film meniscus height at the lower lid margin (at the centre of the inferior limbus), height is measured in micrometers | first week post-operatively | 
| Evaluation of the tear level within the plug | Either within the lower half or upper half of the plug | first week post-operatively | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
AS-OCT, Punctual stenosis, Perforated Lacrimal Punctal Plugs
Point-spectroscopy Trial

Study Overview
=================
Brief Summary
-----------------
Evaluation and characterization of autofluorescence signals of tissue in and around wounds as identified by MolecuLight fluorescence image.

Detailed Description
-----------------
Evaluate and characterize autofluorescence signals of tissue components in and around wounds identified by MolecuLight FL images using a point spectrometer. The fluorescence spectroscopy data will yield quantitative spectral information, including the relative intensity and emission peak of the biological autofluorescence signatures.

Official Title
-----------------
Spectroscopic Assessment of Autofluorescent Signatures of Tissue in and Around Wounds Identified by MolecuLight i:X Imaging Device

Conditions
-----------------
Wound, Wound of Skin

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients presenting with acute or chronic wounds 18 years or older Willing to consent Exclusion Criteria: Treatment with an investigational drug within 1 month of enrolment Any contra-indication to regular wound care Inability or unwillingness to consent

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Spectra of autofluorescent signatures of tissue in and around the wounds | Spectral characterization (i.e. emission curve including intensity) of the autofluorescence signal from wound tissue and surrounding tissue will be catalogued from all 50 study participants. | 2 months |