Bipolarity - Depression in Children and Adolescent Suicide Attempters: Better Diagnosis to Prevent Recurrence

Study Overview
=================
Brief Summary
-----------------
The purpose of the study is to describe the number of diagnosis of bipolar depression and comorbid suicidal behavior according to the diagnostic criteria of the DSM-5.

Detailed Description
-----------------
This study is a prospective, routine care, covering pediatric population suicidal (who attempted suicide) and suicide (with suicidal ideas with planning) hospitalized in the pediatric hospital in Nice- Lenval Hospital. The main objective of the study is to describe the number of diagnosis of bipolar depression and comorbid suicidal behavior according to the diagnostic criteria of the DSM-5. The secondary objectives are: 1) comparison of the suicide attempt rate of recurrence at 6 months and 12 months among subjects with a diagnosis of mood disorder (depression or bipolar) and subjects with a diagnosis mood disorder; 2) the identification of specific suicidal recurrence risk factors in the diagnosis of mood disorder; 3) comparing the diagnostic evaluation field (ICD-10 criteria) vs standardized assessment (DSM-5 criteria). For this the investigator propose an observational cohort study, single center, on a trailing 12 months after inclusion. The topics are selected and included consecutively over a period of 12 months. The inclusion criteria are: 1) children - teenagers age: 6-18 years inclusive; 2) hospitalization for suicide attempt or suicidal ideation with planning in the Pediatric Hospital of Nice Lenval Hospital; 3) French patients; 4) speaking parents 5) affiliation to the social security system. The criterion for inclusion is not the refusal or failure to realize the Kiddie - SADS with the subject and / or his parents. The number of subjects to be included is estimated at 100. At baseline: standardized assessment of comorbid psychiatric diagnosis according to DSM-5 Mood disorders according to DSM-IV R criteria for other diagnoses. The investigatorwill use the KIDDIE-SADS, semi-structured interview for diagnostic purposes adapted to the DSM for that assessment. The patients were distributed into two groups: mood disorder group - group without mood disorder. In parallel, the field team evaluates blind psychiatric diagnosis according to ICD-10 criteria. The population included subjects is described: clinicaly - demographic - overall operation - individual and family psychiatric history. The topics included are reassessed at 6 months and 12 months. At 6 months: occurrence of an attempted suicide or recurrence of suicidal thoughts with planning - overall operation - clinical condition. At 12 months: re standardized diagnostic evaluation with KIDDIE-SADS and re identical clinical evaluation at 6 months. The recidivism risk factors and recidivism rates are evaluated in both groups. The primary endpoint of the study is the attempt recurrence rate of suicide.

Official Title
-----------------
Bipolarity - Depression in Children and Adolescent Suicide Attempters: Better Diagnosis to Prevent Recurrence

Conditions
-----------------
Suicide, Attempted

Intervention / Treatment
-----------------
* Other: diagnosis of bipolar disorder and comorbid depression


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: hospitalized at Fondation Lenval/ pediatric hospital of Nice-CHU Lenval for suicide attempt and / or suicidal ideas with planning French-speaking patient Francophone parents Affiliation to asocial security system Exclusion Criteria: Refusal or impossibility of carrying out the KIDDIE-SADS questionnaire

Ages Eligible for Study
-----------------
Minimum Age: 6 Years
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Screening
Intervention Model: Single Group Assignment
Interventional Model Description: Describe the number of diagnosis of bipolar disorder and comorbid depression of suicidal behaviors in the pediatric population.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: bipolar disorder and comorbid depression<br>number of diagnosis of bipolar disorder and comorbid depression of suicidal behaviors in the pediatric population. | Other: diagnosis of bipolar disorder and comorbid depression<br>* Evaluation of the number of diagnosis of bipolar disorder and comorbid depression<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| diagnosis of bipolar disorder and comorbid depression | Describe the number of diagnosis of bipolar disorder and comorbid depression of suicidal behaviors in the pediatric population. | At baseline during inclusion visit | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| recurrence rates | compare the recurrence rates at 6 and 12 months between bipolar and depressed patients and patients not diagnosed with a mood disorder | comparison between 6 month and 12 month | 
| risk factors for suicidal recidivism | To compare the risk factors for suicidal recidivism between bipolar and depressed patients | At baseline during inclusion visit | 
| comorbid diagnoses | Compare the comorbid diagnoses obtained by the standardized assessment (Diagnostic and Statistical Manual of Mental Disorders-5 (DSM-5) for mood disorders and DSM-IVR for other diagnoses) vs. field assessment (CIM-10) (Classification internationale des maladies-10) | At baseline during inclusion visit | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Suicide