The Effect of Video Game Exercise on Dynamic Balance and Gait in Individuals With Huntington's Disease

Study Overview
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Brief Summary
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To examine the benefits of using a video-game, Dance, Dance, Revolution, as an exercise modality to improve gait and balance in individuals with Huntington's disease.

Detailed Description
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The primary purpose of this study was to determine the effectiveness of a therapist-guided Video-game Biofeedback Modulated Exercise (ViBE) program administered via Dance Dance Revolution to improve dynamic balance, gait and mobility in individuals with Huntington's Disease. Secondary aims were to explore whether the ViBE intervention would improve quality of life, fall risk, and neuropsychological functions. The investigators hypothesized that the video-game program would lead to greater improvements in walking, dynamic balance, quality of life, fall risk, and neuropsychological function than a control handheld video game program. Since motivation is essential to the long-term maintenance of an exercise program the investigators were also interested in finding out how successful people with Huntington's Disease were at playing Dance Dance Revolution, what their perceptions were of playing the game, and whether they thought that it was beneficial

Official Title
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The Effect of Video Game Biofeedback Modulated Exercise (ViBE)on Dynamic Balance and Gait in Individuals With Huntington's Disease

Conditions
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Huntington's Disease

Intervention / Treatment
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* Other: Video game exercise using Dance Dance Revolution
* Other: hand-held video game


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: adults 18 - 79 with a diagnosis of Huntington's disease Exclusion Criteria: cannot walk 10 feet without assistance, any other neurologic condition

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 79 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Crossover Assignment
Interventional Model Description: Participants completed one arm of the study and then crossed over into the other arm of the study
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: video game exercise<br>Video game exercise using Dance Dance Revolution | Other: Video game exercise using Dance Dance Revolution<br>* use of the video-game, Dance, Dance Revolution as an exercise to improve gait and balance<br>* Other names: video-game based exercise;Other: hand-held video game<br>* hand-held video games<br>|
| Other: control<br>hand-held video game control | Other: Video game exercise using Dance Dance Revolution<br>* use of the video-game, Dance, Dance Revolution as an exercise to improve gait and balance<br>* Other names: video-game based exercise;Other: hand-held video game<br>* hand-held video games<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Gait Parameters | utilized GAITRite to obtain spatiotemporal measures of gait: forward velocity. | 6 weeks | 
| Gait Parameters | utilized GAITRite to obtain spatiotemporal measures of gait: forward stride length. | 6 weeks | 
| Gait Parameters | utilized GAITRite to obtain spatiotemporal measures of gait: forward swing percent. | 6 weeks | 
| Gait Parameters | utilized GAITRite to obtain spatiotemporal measures of gait: forward double support percent. | 6 weeks | 
| Gait Parameters | utilized GAITRite to obtain spatiotemporal measures of gait: forward heel to heel base of support. | 6 weeks | 
| Gait Parameters | utilized GAITRite to obtain spatiotemporal measures of gait: backwards velocity. | 6 weeks | 
| Gait Parameters | utilized GAITRite to obtain spatiotemporal measures of gait: backwards stride length. | 6 weeks | 
| Gait Parameters | utilized GAITRite to obtain spatiotemporal measures of gait: backwards swing percent. | 6 weeks | 
| Gait Parameters | utilized GAITRite to obtain spatiotemporal measures of gait: backwards double support percent. | 6 weeks | 
| Gait Parameters | utilized GAITRite to obtain spatiotemporal measures of gait: backwards heel to heel base of support. | 6 weeks | 
| Gait Parameters | utilized GAITRite to obtain spatiotemporal measures of gait: obstacle velocity. | 6 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Tinetti Mobility Test | Observation of gait and balance with quantifiable 16-item assessment with an ordinal scale of 0-2 for up to a total score of 32, with higher scores indicating better performance. It is reliable and predicts falls among those with Parkinson's disease and Huntington's disease. | 6 weeks | 
| Four Square Step Test | Examines ability to step over an object in multiple directions and is timed. Participants are instructed to step over a cane into each square in a specific order. Faster times indicate better balance. It has been shown to predict falls in the elderly. | 6 weeks | 
| Activities-Specific Balance Confidence Scale | Individuals rate their balance confidence from 1-100 on 16 tasks and total score is the mean; higher scores indicate greater confidence and lower fall risk. The Activities-Specific Balance Confidence Scale is reliable and valid in elderly and neurological populations. | 6 weeks | 
| World Health Organization Quality of Life | This questionnaire is a measure of quality of life addressing 4 domains including physical, psychological, social, and environment health. Responses on 26 items are on a five-point scale (from 1 = very dissatisfied to 5 = very satisfied) and each item is added to achieve a total score for each domain. The mean score for each domain is calculated then multiplied by 4 to get the domain score which are then transformed to a scaled score of 0-100 comparable to the original WHOQOL-100 therefore a total score between 0-400 with high scores indicating better quality of life. The WHOQOLBref has good reliability and validity. | post intervention and post hand-held game, each lasts 6 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Huntington's Disease, gait, exercise, balance, video game