Dim Light at Night in Patients With Obstructive Sleep Apnea

Study Overview
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Brief Summary
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With the advent of electricity, light at night has become a ubiquitous part of our society. The main purpose of this study is to determine whether sleeping with dim light (40 lux), the brightness of a night light) in your bedroom for 5 consecutive nights will result in increased markers of inflammation in the blood compared to sleeping in darkness during the night in patients with obstructive sleep apnea (OSA). A secondary aim is to examine the effects on insulin sensitivity, other blood proteins, and RNA molecules as a result of sleeping with dim light. RNA molecules are substances in blood that dictate what type of proteins the body should make.

Detailed Description
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The primary objective of this study is to determine whether sleeping with dLAN (40 lux) for 5 consecutive nights will result in increased markers of inflammation compared to sleeping in darkness (< 1 lux) during the night in patients with OSA. A secondary aim is to examine the effects on insulin sensitivity, adipokines, and RNA molecules. The risks associated with this study are minimal compared to the potential benefits. Knowledge about the effects of sleeping with dim light on inflammation in patients with OSA is important and would guide future recommendations about proper sleep hygiene. This research may also guide future recommendations about light conditions in other environments such as hospital bedrooms.

Official Title
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Effects of Sleeping With Dim Light at Night in Patients With Obstructive Sleep Apnea

Conditions
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Obstructive Sleep Apnea (OSA)

Intervention / Treatment
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* Other: dim light at night


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: • 18 -60 years of age. Willing and able to give informed consent AHI >10 episodes per hour based on a prior PSG. Patients who have been started on treatment for OSA with either Continuous Positive Airway Pressure (CPAP) or dental device will be eligible for the study as long as they have been compliant with treatment for at least 30 days. Exclusion Criteria: • Incapable of giving informed consent Under the age of 18 Currently sleeping with lights on in the bedroom Excessive alcohol consumption Excessive alcohol use is defined as: More than 3 glasses of wine a day More than 3 beers a day More than 60 mL of hard liquor a day Room air oxyhemoglobin saturation < 88% Use of home oxygen Use of corticosteroids and other immunosuppressive medications. Diagnosis of: HIV, Connective Tissue Disease (Lupus, Rheumatoid arthritis), Inflammatory Bowel Disease.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: usual condition<br>sleep in usual room light condition for 5 nights | |
| Experimental: dLAN<br>sleep with dim light at night for 5 nights | Other: dim light at night<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Exposure to Dim Light at Night | The main purpose of this study is to determine whether sleeping with dim light (40 lux), the brightness of a night light) in your bedroom for 5 consecutive nights will result in increased markers of inflammation in the blood compared to sleeping in darkness during the night in patients with obstructive sleep apnea (OSA). | 5 consecutive nights |