Quality of Pediatric Resuscitation in a Multicenter Collaborative

Study Overview
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Brief Summary
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This is a prospective, observational, multi-center cohort study of pediatric cardiac arrests. The purpose of the study is to determine the association between chest compression mechanics (rate, depth, flow fraction, compression release) and patient outcomes. In addition, the investigators will determine the association of post cardiac arrest care with patient outcomes.

Detailed Description
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Cardiac arrests in children are a major public health problem. Thousands of children each year in the USA are treated with cardiopulmonary resuscitation (CPR) and managed after their cardiac arrest. Neurological outcomes following these in-hospital CPR events are often abnormal. As children with neurological deficits following CPR are a major burden for families and society, improving neurological outcomes through superior chest compression delivery during CPR and optimal care and management after cardiac arrest is an important clinical goal. Therefore, the objective of this investigation is to obtain evidentiary support to associate the relationship of quantitative CPR quality data (depth, rate, chest compressions (CC) fraction, compression release) during CPR, post-cardiac arrest care (PCAC) and patient survival in those children who suffer an arrest within the study (RES-Q) Network.

Official Title
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Quality of Pediatric Resuscitation in a Multicenter Collaborative: An Observational Study

Conditions
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Cardiac Arrest, Cardiopulmonary Arrest

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient received chest compressions for at least 1 minute Patient between gestational age ≥37 weeks and 17 years of age Patient had a quality of CPR measurements device (eg., Zoll Medical chest compression sensor) in place during chest compressions Exclusion Criteria: Patient on extracorporeal membrane oxygenation (ECMO) therapy at beginning of CPR event

Ages Eligible for Study
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Minimum Age: 0 Years
Maximum Age: 17 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Pediatric Cardiac Arrests<br>Pediatric cardiac arrests requiring chest compressions for at least 1 minute managed at clinical centers identified as part of standard clinical operations. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Aggregate score composed of American Heart Association (AHA) recommended depth, rate, and chest compression fraction during CPR | Primary outcome: Guideline-compliant CPR which will be determined by an aggregate score comprised of the following three components: depth, rate, and chest compression fraction. The three components will be analyzed in 30 and 60 second epochs. Guideline-compliant CPR requires that each component meet the following criteria: 1) Age-determined American Heart Association (AHA) guideline recommended depth; 2) rate ≥ 90 and ≤ 120 CC/min; and 3) CC Fraction ≥ 0.80. Depth, rate, and CC Fraction will be calculated for each epoch and an aggregate score will be assigned. The primary analysis will be performed on that total score. | 10 Years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Chest compressions, Cardiopulmonary Resuscitation