Comparison of Pesticide and Pharmaceutical Contaminants Levels in Placenta and Cord Blood Samples of Pregnant Women With Fetal Growth Retardation and Healthy Pregnant Women

Study Overview
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Brief Summary
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Aim: In this study, pesticide and pharmaceutical contaminants levels in the placenta and cord blood of pregnant women with fetal growth retardation and healthy pregnant women will be compared in placenta and cord blood samples after delivery.

Detailed Description
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The study will be conducted with a total of 40 pregnant women, 20 of whom are in the control groups and those with FGR diagnoses. Cases in both groups will be matched in terms of demographic information. Demographic information (including socioeconomic status, educational level, region of residence), ultrasound and Doppler examination results, newborn weight at birth, APGAR score, gender, mode of delivery, whether there is a need for neonatal intensive care or not will be recorded.

Official Title
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Comparison of Pesticide and Pharmaceutical Contaminants Levels in Placenta and Cord Blood Samples of Pregnant Women With Fetal Growth Retardation and Healthy Pregnant Women

Conditions
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Fetal Growth Retardation

Intervention / Treatment
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* Other: . Pesticide and Pharmaceutical analysis


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Between the ages of 18-40 years Gestational age between 320/7 - 396/7 weeks Singleton pregnancy For the FGR group: estimated fetal weight <10th percentile For the control group: being healthy pregnant Intact amniotic membrane Exclusion Criteria: Multiple pregnancies Cardiovascular disease Chronic hypertension Autoimmune disease Intrahepatic cholestasis of pregnancy Preeclampsia-eclampsia Sepsis Placenta accreta spectrum Abnormalities of placenta The chromosomal or congenital structural anomaly of the fetus Smoking BMI >30 kg/m2

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group 1: FGR group<br>Estimated fetal weight <10th percentile | Other: . Pesticide and Pharmaceutical analysis<br>* Pesticide and Pharmaceutical analysis will be done with LC-MS/MS device.<br>|
| Group 2: Control group<br>Healthy pregnants who will give birth 37th and after gestational week | Other: . Pesticide and Pharmaceutical analysis<br>* Pesticide and Pharmaceutical analysis will be done with LC-MS/MS device.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pesticide and Pharmaceutical analysis | Pesticide and pharmaceutical contaminants levels in pregnant women's placenta and cord blood will be measured in placenta and cord blood samples after delivery. | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Multi logistic regression analysis. | If there is a significant difference in other data, including the pesticide and pharmaceutical contaminants levels, in the FGR group, the effect of each factor on the development of FGR will be analyzed by multi logistic regression analysis. | 1 month | 
| ROC analysis | If the pesticide and pharmaceutical contaminants levels is found to be significantly higher in the FGR group, the cut-off value will be obtained by ROC analysis. | 1 month |