Effects of Anesthetic Techniques on Renal Function

Study Overview
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Brief Summary
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This study evaluates Different effects of two anesthetic techniques on renal function during the perioperative period of cardiac surgery in children.

Detailed Description
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Acute kidney injury is one of the major complications after heart surgery, which increases the mortality of patients. Therefore, early prevention and detection of acute kidney injury is particularly important. In recent years, more and more studies have shown that both sevoflurane, an inhaled anesthetic widely used in clinical practice, and propofol, an intravenous anesthetic, have protective effects on kidneys. The aim of this study was to investigate the perioperative effects of two different anesthetic techniques on renal function for pediatric cardiac surgery.

Official Title
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Different Effects of Two Anesthetic Techniques on Renal Function During the Perioperative Period of Cardiac Surgery in Children

Conditions
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Congenital Heart Disease, Acute Kidney Injury

Intervention / Treatment
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* Other: inhalation anesthesia
* Other: Total intravenous anesthesia


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: children with congenital heart disease <3 years of age Exclusion Criteria: preoperative renal insufficiency; renal malformation, kidney absence

Ages Eligible for Study
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Minimum Age: 1 Minute
Maximum Age: 3 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group A: Sevoflurane, sufentanil and rocuronium<br>sevoflurane (1-3%)and sufentanil (0.5-2 mcg/kg/h) and rocuronium (0.3～0.6mg/kg/h) used intraoperatively as required | Other: inhalation anesthesia<br>* sevoflurane was used to maintain anesthesia<br>|
| Group B: Propofol, sufentanil and rocuronium<br>propofol (4-12 mg/kg/h) and sufentanil (0.5-2 mcg/kg/h/) and rocuronium (0.3～0.6mg/kg/h) used intraoperatively as required | Other: Total intravenous anesthesia<br>* propofol was used to maintain anesthesia<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| renal blood flow | Changes of blood flow information of renal artery was obtained before anesthesia induction, after anesthesia, at the end of operation and 24 hours after surgery, unit(cm/s) | 2 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| neutrophil gelatinase-associated lipocalin , NGAL | Changes of blood NGAL were obtained before and 2 hours after surgery, unit(ng/ml) | 2 days | 
| creatinine | Changes of creatinine before and 3 days after acquisition, unit (mmol/L) | 3 and 4 days | 
| Mean arterial pressure | Mean arterial pressure synchronized with renal blood flow was recorded, unit (mmHg) | 2 days | 
| cardiopulmonary bypass (CPB) time | Cardiopulmonary bypass time was recorded, unit(minutes) | 24 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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propofol,sevoflurane