Study of TT-00420 Tablet as Monotherapy and Combination Therapy in Patients With Advanced Solid Tumors

Study Overview
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Brief Summary
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This is a Phase Ib/II, multicenter, open-label study to evaluate the safety and preliminary efficacy of TT-00420 tablet, as monotherapy or in combination regimens, in patients with advanced solid tumors.

Detailed Description
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Study consists of three arms, Arm A is a Phase Ib/II study of TT-00420 tablet monotherapy, Arm B is a Phase Ib/II study of TT-00420 tablet in combination with nab-paclitaxel (Abraxane®) and Arm C is a PK run-in study of TT-00420 tablet. Arm A: TT-00420 Tablet Monotherapy Phase Ib will enroll patients with preferred indications including metastatic cholangiocarcinoma, HER2-negative breast cancer including TNBC, bladder cancer, small cell lung cancer, prostate cancer, thyroid cancer, sarcoma, gastric cancer, gallbladder cancer and other advanced solid tumors to receive TT-00420 monotherapy. Based on preliminary efficacy results, Phase II will enroll additional patients in select indications to evaluate the efficacy of TT-00420 monotherapy. Arm B: TT-00420 tablet in combination with nab-paclitaxel (Abraxane®) Arm B will enroll patients with metastatic HER2-negative breast cancers, including triple-negative breast cancer (TNBC). Phase Ib will be a dose escalation study of TT-00420 in combination with nab-paclitaxel, guided by 3+3 design, to determine a Recommended Phase 2 Dose (RP2D). Phase II will enroll additional patients with metastatic HER2-negative breast cancers to further evaluate the efficacy of the combination regimen. Arm C: PK Run-in Study of TT-00420 Tablet Arm C will enroll patients with preferred indications including cholangiocarcinoma, TNBC/HER2- negative breast cancer, prostate cancer, sarcoma, hepatocellular carcinoma (HCC), bladder cancer, small cell lung cancer, thyroid cancer, gastric cancer, gallbladder cancer and other advanced solid tumors to receive TT-00420 monotherapy administered as once daily (q.d.) or twice daily (b.i.d.).

Official Title
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A Phase Ib/II, Multicenter, Open-Label Study of TT-00420 Tablet, as Monotherapy or in Combination Regimens, in Patients With Advanced Solid Tumors

Conditions
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Advanced Solid Tumor, Cholangiocarcinoma, HER2-negative Breast Cancer, Triple Negative Breast Cancer, Bladder Cancer, Small-cell Lung Cancer, Prostate Cancer, Thyroid Cancer, Sarcoma, Gastric Cancer, Gallbladder Cancer

Intervention / Treatment
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* Drug: TT-00420
* Combination Product: Nab-Paclitaxel


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ≥ 18 years of age Histopathological or cytologically documented locally advanced or metastatic solid tumors who have no available standard therapeutic treatment options At least one measurable lesion as defined by RECIST V1.1 criteria for solid tumors Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 Adequate organ function confirmed at screening and within 10 days of initiating treatment, as evidenced by: Absolute neutrophil count (ANC) ≥ 1.5 x 10^9/L Hemoglobin (Hgb) ≥ 8 g/dl Platelets (plt) ≥ 75 x 10^9/L AST/SGOT and ALT/SGPT ≤ 2.5 x Upper Limit of Normal (ULN) or ≤ 5.0 x ULN if liver metastases are present Total bilirubin ≤ 1.5 x ULN Calculated creatinine clearance ≥ 50 mL/min (Cockcroft Gault formula) Negative pregnancy test within 72 hours before starting study treatment in all premenopausal women and women < 12 months after the onset of menopause Must agree to take sufficient contraceptive methods to avoid pregnancy during the study and until at least 6 months after ceasing study treatment Able to sign informed consent and comply with the protocol Exclusion Criteria: Women who are pregnant or lactating Women of child-bearing potential (WOCBP) who do not use adequate birth control Patients with any hematologic malignancy, including leukemia (any form), lymphoma, and multiple myeloma Patients with a history of primary central nervous system tumors or carcinomatous meningitis. Patients with the following mood disorders as judged by the Investigator or a psychiatrist: Medically documented history of or active major depressive episode, bipolar disorder (I or II), obsessive-compulsive disorder, schizophrenia; a history of suicidal attempt or ideation, or homicidal ideation (immediate risk of doing harm to others) ≥ CTCAE grade 3 anxiety Impaired cardiac function or significant diseases, including but not limited to any of the following: left ventricular ejection fraction (LVEF) < 45% as determined by multigated acquisition (MUGA) scan or echocardiogram (ECHO) Congenital long QT syndrome QTcF ≥ 480 msec on screening ECG Unstable angina pectoris ≤ 3 months prior to starting study drug Acute myocardial infarction ≤ 3 months prior to starting study drug Patients with: unresolved diarrhea ≥ CTCAE grade 2, or impairment of gastrointestinal (GI) function, or GI disease that may significantly alter the absorption of TT-00420 Other concurrent severe and/or uncontrolled concomitant medical conditions (e.g., uncontrolled hypertension, uncontrolled hypertriglyceridemia, or active or uncontrolled infection) that could cause unacceptable safety risks or compromise compliance with the protocol Patients who have received chemotherapy, targeted therapy, or immunotherapy ≤ 4 weeks (6 weeks for nitrosourea or mitomycin-C) prior to starting study drug or who have not recovered from side effects of such therapy Patients who have received wide field radiotherapy ≤ 4 weeks or limited field radiation for palliation ≤ 2 weeks prior to starting study drug or who have not recovered from side effects of such therapy Patients who have undergone major surgery ≤ 4 weeks prior to starting study drug or who have not recovered from side effects of such therapy Patients who have been treated with any hematopoietic colony-stimulating growth factors (e.g., G-CSF, GM-CSF) ≤ 4 weeks prior to starting study drug. Patients who are currently receiving treatment with therapeutic doses of warfarin sodium or any other coumarin-derivative anticoagulants Patients who have received systemic corticosteroids ≤ 2 weeks prior to starting study drug or who have not recovered from the side effects of such treatment. Patients who are currently receiving treatment with strong CYP3A inhibitors or inducers ≤ 2 weeks prior to starting study drug. Known diagnosis of human immunodeficiency virus (HIV) infection (HIV testing is not mandatory; patients with well controlled HIV might be enrolled) Known history of active infection with Hepatitis B or Hepatitis C Has received a live-virus vaccination within 30 days of planned first dose Inability to swallow or tolerate oral medication Has a history or current evidence of any condition, therapy, or laboratory abnormality that, in the opinion of the investigator, might confound the results of the trial, interfere with the patient's safe participation and compliance in the trial.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Study will consist of three arms: Arm A (TT-00420 Tablet Monotherapy), Arm B (TT-00420 tablet in combination with nab-paclitaxel (Abraxane®)) and Arm C (PK Run-in Study of TT-00420 Tablet).
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Monotherapy Cohorts<br>TT-00420 tablets will be administered once daily in 28-day cycles. | Drug: TT-00420<br>* TT-00420 tablet will be administered orally once daily per protocol defined schedule.<br>|
| Experimental: Dose Escalation Cohorts (Combination Therapy)<br>TT-00420 tablets will be administered once daily in 28-day cycles. Nab-paclitaxel 100 mg/m^2 will be administered intravenously on Day 1, 8, and 15 of each 28-day cycle. Dose escalation will be guided by a 3+3 design in Phase Ib to determine the recommended phase 2 dose (RP2D). | Drug: TT-00420<br>* TT-00420 tablet will be administered orally once daily per protocol defined schedule.<br>Combination Product: Nab-Paclitaxel<br>* Nab-Paclitaxel would be administered via infusion on Day 1,8, and 15 of 28-day cycle<br>|
| Experimental: PK Run-in Cohorts<br>TT-00420 tablets will be administered once or twice daily in 28-day cycles according to assigned cohort. | Drug: TT-00420<br>* TT-00420 tablet will be administered orally once daily per protocol defined schedule.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of Participants With Abnormal Laboratory Values and/or Adverse Events That Are Related to Treatment | As assessed per NCI Common Toxicity Criteria for Adverse Events, version 5.0 | Up to 30 days from study discontinuation | 
| Dose limiting toxicity (DLT) | Dose escalation cohorts are monitored and assessed using the NCI Common Toxicity Criteria for Adverse Events, version 5.0. | Up to 28 days from the first dose | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Objective Response Rate (ORR) | The proportion of subjects who achieved a complete response (CR) or a partial response (PR) based on RECIST version 1.1. | Through study completion, an average of 9 months. | 
| Disease Control Rate (DCR) | Defined as CR + PR + stable disease (SD) based on RECIST version 1.1. | Through study completion, an average of 9 months. | 
| Duration of Objective Response (DOR) | Duration of response for CR or PR based on RECIST version 1.1. | Through study completion, an average of 9 months. | 
| Progression Free Survival (PFS) |  | From first study drug administration until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 24 months | 
| Overall Survival (OS) |  | From first study drug administration until the date of death from any cause, assessed up to 24 months | 
| Area under the curve (AUC0-∞) | Blood samples will be collected at designated time points for pharmacokinetic analysis of TT-00420 and/or nab-paclitaxel. | From Cycle 1 Day 1 to Cycle 2 Day 1 (each cycle is 28 days) | 
| Area under the curve (AUC0-t) | Blood samples will be collected at designated time points for pharmacokinetic analysis of TT-00420 and/or nab-paclitaxel. | From Cycle 1 Day 1 to Cycle 2 Day 1 (each cycle is 28 days) | 
| Maximum observed concentration (Cmax) | Blood samples will be collected at designated time points for pharmacokinetic analysis of TT-00420 and/or nab-paclitaxel. | From Cycle 1 Day 1 to Cycle 2 Day 1 (each cycle is 28 days) | 
| Half-life (T1/2) |  | From Cycle 1 Day 1 to Cycle 2 Day 1 (each cycle is 28 days) | 
| Time to Maximum Concentration (Tmax) |  | From Cycle 1 Day 1 to Cycle 2 Day 1 (each cycle is 28 days) | 
| Volume of Distribution (Vd) |  | From Cycle 1 Day 1 to Cycle 2 Day 1 (each cycle is 28 days) |