Airway Responsiveness in Patients With AECOPD Mechanical Ventilation by Inspiratory and Bronchial Dilation Testchronic Obstructive Pulmonary Disease

Study Overview
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Brief Summary
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In the patients with COPD mechanical ventilation, the bronchial dilatation is very common. However, the evaluation of the efficacy of the medical examination and other subjective indicators, such as doctors, depends on the doctor's experience; at present, there is no objective evaluation index. For patients with mechanical ventilation, the risk of cross infection can not only increase the risk of cross infection, but also increase the workload of clinical doctors and nurses. Therefore, this study proposes an objective evaluation method to evaluate the response of COPD patients to bronchial dilation. The hypothesis of this study can be used to guide the clinical medication through the test of the bronchus. If the patients with bronchial dilation test positive were used in the test, the patients were not used. In this evaluation method, the changes of airway resistance were measured by the accurate measurement of the patients with inhaled bronchial dilatation.

Conditions
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Lung Disease,Obstructive

Intervention / Treatment
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* Drug: Salbutamol Aerosol
* Drug: No drugs


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Acute exacerbation of chronic obstructive pulmonary disease The mechanical ventilation time of the outdoor endotracheal intubation in the intensive care unit was less than 48 hours Exclusion Criteria: asthma has received tracheotomy long term mechanical ventilation (which has been accepted for more than 21 days). severe pneumonia Patients who cannot use a patient with bronchial dilation there's a taboo on the use of a sedative. refusal to participate in the study 48 hours to pull out the tube
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Atomization inhalation<br>First of all, investigators need to give patients to do the test, the result is more than 12% is positive group, less than 12% is negative group.Second, randomly selected into the atomization group | Drug: Salbutamol Aerosol<br> <br> * Other names: Ammonium bromide bromide aerosol;|
| Active Comparator: Without atomization inhalation<br>First of all, investigators need to give patients to do the test, the result is more than 12% is positive group, less than 12% is negative group.Secondly, the random selection is not the atomization group | Drug: No drugs<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| airway resistance | The first test of bronchial dilatation | 1 day | 
| Respiratory mechanics index:PEEPi |  | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mechanical ventilation time |  | 28 days | 
| length of hospital stay |  | 30 days | 
| Costs of hospitalization expenses |  | 30 days | 
| Routine blood test:Eosinophilic cells |  | 7days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Mechanical ventilation, Chronic obstructive pulmonary disease, Airway resistance, Bronchial dilation test