Whole-body Electromyostimulation Versus Conventional Low-volume Strength Training in Overweight Individuals

Study Overview
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Brief Summary
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The main purpose of this study is to compare the effects of whole-body electromyostimulation versus a conventional low-volume strength-training program, each combined with an individualized, weight-reducing diet, on the cardiometabolic risk profile, muscle strength, body composition, inflammatory markers and subjective health outcomes in overweight individuals at increased cardiometabolic risk.

Official Title
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Comparison of the Effects of Whole-body Electromyostimulation Versus Conventional Low-volume Strength Training in Overweight Individuals at Increased Cardiometabolic Risk

Conditions
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Overweight and Obesity, Metabolic Syndrome

Intervention / Treatment
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* Other: Control
* Other: Standard Strength Training
* Other: Low-volume Strength Training
* Other: Whole-Body Electromyostimulation (WB-EMS)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Body Mass Index >25 presence of at least 2 cardiometabolic risk factors Exclusion Criteria: Healthy persons or patients under age Overweight persons without any additional cardiometabolic risk factors Pregnancy, Lactation Psychological disorders, epilepsy, sever neurological disorders Participation in other exercise- or nutrition studies within the last 6 months acute cardiovascular disease malignant disease Rheuma Intake of anabolic drugs, Skin injuries in the area of electrode placements Electronic implants (defibrillator, pacemaker) Persons in mental hospitals by order of authorities or jurisdiction

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: parallel-group, randomized-controlled study
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Control<br>Nutritional therapy / no exercise | Other: Control<br>* Individualized, weight-reducing nutritional therapy and counseling, during a study period of 12 weeks<br>|
| Experimental: Standard Strength Training<br>Nutritional therapy combined with a Standard Strength Training program | Other: Standard Strength Training<br>* Procedures: Nutritional therapy (individualized, weight-reducing nutritional therapy and counseling) during a study period of 12 weeks combined with a standard strength training program: 5 strength training exercises (chest, upper/lower back, abdominals, legs) 3 sets per exercise time-effort per session:  90 min 2 training sessions per week duration of exercise intervention: 12 weeks<br>|
| Experimental: Low-volume Strength Training<br>Nutritional therapy combined with a low-volume Strength Training program | Other: Low-volume Strength Training<br>* Procedures: Nutritional therapy (individualized, weight-reducing nutritional therapy and counseling) during a study period of 12 weeks combined a low-volume strength training program: 5 strength training exercises (chest, upper/lower back, abdominals, legs) 1 set per exercise time-effort per session:  20 min 2 training sessions per week duration of exercise intervention: 12 weeks<br>|
| Experimental: Whole-body Electromyostimulation<br>Nutritional therapy combined with Whole-Body Electromyostimulation | Other: Whole-Body Electromyostimulation (WB-EMS)<br>* Procedures: Nutritional therapy (individualized, weight-reducing nutritional therapy and counseling) during a study period of 12 weeks combined with WB-EMS: time-effort per session:  20 min duration of exercise intervention: 12 weeks<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Metabolic Syndrome Z-Score (MetS-Z-Score) | MetS-Z-Score will be calculated from each individual's measures of waist circumference, mean arterial blood pressure, triglycerides, and HDL-cholesterol, based on equations specific to sex. | 12 weeks (baseline to 12 week follow-up assessment) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Muscle strength | Muscle strength of the five major muscle groups (chest, upper back, lower back, abdominals, legs) will be assessed by using specific strength-training devices (Butterfly, Pull-down, Hyperextension, Abdominal Crunch, Leg-Press) | 12 weeks (baseline to 12 week follow-up assessment) | 
| Body Composition | Muscle mass, fat mass and body water will be measured by Bioelectrical Impedance Analysis (BIA) | 12 weeks (baseline to 12 week follow-up assessment) | 
| Cardiorespiratory Fitness (CRF) | CRF will be assessed by measuring Maximum Oxygen uptake (VO2max) | 12 weeks (baseline to 12 week follow-up assessment) | 
| Inflammation status | Inflammation will be assessed by measuring Levels of CRP and inflammatory cytokines and other inflammatory blood markers | 12 weeks (baseline to 12 week follow-up assessment) | 
| Health-related quality of life | Health-related quality of life will be assessed by using the standardized and validated EQ-5D-5L Questionnaire | 12 weeks (baseline to 12 week follow-up assessment) | 
| Pain scores | Pain scores will be assessed by using the standardized and validated Chronic Pain Grade Questionnaire (CPGQ) | 12 weeks (baseline to 12 week follow-up assessment) | 
| Perceived stress | Perceived stress will be assessed by using the standardized and validated Perceived Stress Questionnaire (PSQ) | 12 weeks (baseline to 12 week follow-up assessment) | 
| Subjective work ability | Subjective work ability will be assessed by using the standardized and validated Work Ability Index Questionnaire (WAI) | 12 weeks (baseline to 12 week follow-up assessment) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Exercise, Strength Training, Health Promotion, Inflammation, Body Composition