Clinical Comparison of Topical Application of Alvogyl Versus Hyaluronic-Acid Gel in Management of Pain And Palatal Wound Healing

Study Overview
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Brief Summary
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The aim of the study is to evaluate the effect of application of Alvogyl versus hyaluronic acid in decreasing postoperative pain and promoting healing in the palatal wound following the free gingival graft procedure

Detailed Description
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Postoperative pain and bleeding are the most common complications after palatal graft harvesting, also postsurgical swelling have been reported. Although hemostatic agents, mechanical barriers, bioactive materials, antibacterial and antiseptic agents and herbal products have been found effective in preventing such complications, an ideal support could not be specified for this purpose. Further, undesired side effects such as delayed wound healing/foreign body reaction have been reported . No gold standard has been identified, thus there is a need for further investigations aiming to reach the best possible treatment modality for pain relief and prevention of reported complications following harvesting of palatal graft .

Official Title
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Clinical Comparison of Topical Application of Alvogyl Versus Topical Application of Hyaluronic-Acid Gel in Management of Pain And Palatal Wound Healing : A Randomized Controlled Clinical Trial

Conditions
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Wound Healing

Intervention / Treatment
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* Other: Alvogyl


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with mucogingival defects scheduled for free gingival graft Age from 18 years up to 60 Medically healthy patient Exclusion Criteria: Systemic diseases that may be a contraindication for any surgeries. Loss of maxillary premolars and molars. Pregnancy or lactation Smoking

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: application of Alvogyl in the palatal wound with stent<br> | Other: Alvogyl<br>* application of Alvogyl in the palatal wound with stent versus hyaluronic acid application<br>* Other names: Hyaluronic acid;|
| Other: application of 0.2% Hyaluronic acid is placed in the palatal wound with stent .<br> | Other: Alvogyl<br>* application of Alvogyl in the palatal wound with stent versus hyaluronic acid application<br>* Other names: Hyaluronic acid;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| postoperative pain | Pain through one week using the visual analogue scale (VAS) | 7th days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Wound healing | Wound healing index through one month . The healing index has 5 grades which are 5(excellent healing), 4(very good healing), 3 (good healing), 2(poor healing) and 1(very poor healing) | 7th, 14th, 21st and 30th days. |