Sickle Cell Uric Acid (SCUA) - Cohort Repository

Study Overview
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Brief Summary
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The purpose of this research is to study the causes of Sickle Cell kidney disease, as well as to collect and store samples and information about people with Sickle Cell Disease.

Detailed Description
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Sickle Cell Disease causes kidney injury over time, but it is not clear why some individuals have very significant chronic kidney disease and why some do not. The purpose of this research is to study whether having high levels of 'uric acid,' which is a naturally occurring molecule in the body that may increase kidney injury and systemic inflammation, accelerates the progression of chronic kidney disease over time. Researchers will measure the number of participants that have high uric acid levels at the beginning of the study, as well as the number of participants that develop new high levels throughout the study. The study will also try to determine what causes the high uric acid levels in some patients but not others. The results of this study could help understand kidney injury and uric acid in sickle cell disease better.

Official Title
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Sickle Cell Uric Acid (SCUA) - Cohort Repository

Conditions
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Chronic Kidney Diseases, Sickle Cell Disease

Intervention / Treatment
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* Other: No intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 5-29 years Sickle cell disease as diagnosed by hemoglobin electrophoresis, or by newborn screen per standard of care Currently receiving comprehensive sickle cell care at the Children's Hospital of Richmond at VCU or in the adult Internal Medicine sickle cell care clinic at VCU. Exclusion Criteria: Those who have received organ, stem cell, or bone marrow transplantation. - Those who require chronic dialysis

Ages Eligible for Study
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Minimum Age: 5 Years
Maximum Age: 29 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Sickle Cell Disease<br>Patients with sickle cell disease will be followed prospectively | Other: No intervention<br>* No intervention - observational study<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percentage of participants in the sample with hyperuricemia | (i.e. high uric acid levels) out of all patients with a uric acid level measured at baseline. | Baseline | 
| Incidence rate of hyperuricemia per year | Calculate the incidence rate of new cases of hyperuricemia per year in each year of the cohort study | Baseline to year 5 | 
| The mean rate of change of estimated glomerular filtration rate (eGFR) per year in those with hyperuricemia and those with normouricemia | Determine the mean rate of change of eGFR per year for each group. | Baseline to year 5 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Uric acid