Randomized Trial Comparing Lenalidomide With Low Dose Dexamethasone Versus Lenalidomide in Second Line Multiple Myeloma

Study Overview
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Brief Summary
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This is: A prospective, randomized, open, phase II, multi-centre, interventional study. Patients who are in at least PR and have received lenalidomide as 2nd line treatment for MM will be recruited. The patients will be randomized into two groups. Group R will receive lenalidomide 25 mg/day p.o. continuously for 21 days and group Rb will receive a similar dose of lenalidomide with the addition of 40 mg of dexamethasone p.o. on days 1, 8, 15 and 22 of every 28 day treatment cycle. Study includes a maximum of 24 cycles including two consolidating cycles per patients.

Conditions
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Multiple Myeloma

Intervention / Treatment
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* Drug: Revlimid


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Inclusion Criteria - all subjects must: Be at least 18 years of age Subjects must have a documented diagnosis of MM and have either refractory or relapsed and refractory after first line treatment disease defined as: Primary refractory Refractory Relapsed and Refractory Subjects must have undergone prior treatment with one treatment line of anti-myeloma therapy. Induction therapy followed by ASCT and consolidation/maintenance will be considered as one line.Have a confirmed diagnosis of MM Have received lenalidomide after one prior treatment for MM and have reached at least a partial response (PR), according to IMWG criteria, including two consolidating cycles. Subjects have experienced a response at least PR after starting treatment with lenalidomide and cortisone cycles. Have personally signed and dated a legally effective written informed consent form prior to admission to the study. Must be willing and able to understand and comply with the study requirements. Females of childbearing potential must agree to ongoing pregnancy testing and to practice contraception. Male must agree to practice contraception Exclusion Criteria: Any of the following laboratory abnormalities: Absolute neutrophil count (ANC) < 1,000/µL Platelet count < 75,000/ µL Creatinine Clearance < 45 mL/min according to Cockcroft-Gault formula Serum SGOT/AST or SGPT/ALT > 3.0 x upper limit of normal (ULN) Serum total bilirubin > 2.0 mg/dL ECOG performance status <4. Individuals who have had a stem-cell transplant as a 2nd line treatment for MM Individuals who have taken any experimental drugs or participated in a clinical trial within 30 days prior to screening. Individuals with significant psychiatric illness or a clinically significant acute/chronic uncontrolled medical condition that might affect their experience of myeloma symptoms or their ability to describe them. Pregnant or lactating females. Any other clinically significant medical disease or condition that, in the Investigator´s opinion, may interfere with protocol adherence or a subject´s ability to give informed consent.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Revlimid<br> | Drug: Revlimid<br>* Group R:25 mg lenalidomide 21 of 28 days will be given orally as maintenance .<br>|
| No Intervention: Revlimid and dexamethasone<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time to progression |  | 24 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of Participants with Adverse Events | Number of Participants with Adverse Events | participants will be followed for the duration of hospital stay, an expected average of 2 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Relapsed and refractory Multiple Myeloma