Comparison of an Acceleromyography- and Electromyography-based Neuromuscular Monitor With TOF-Watch ® Monitor

Study Overview
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Brief Summary
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A quantitative neuromuscular monitoring device is desirable to titrate the depth of neuromuscular block (NMB) during a procedure, and to prevent residual effects after removal of the endotracheal tube. Unfortunately, the most widely used monitoring technique acceleromyography (AMG) typically implies a series of cumbersome installation and calibration procedures that frequently precludes correct use of these devices in clinical practice. Electromyography (EMG) has recently attracted a lot of attention as an alternative strategy to compensate for the deficiency of AMG-based neuromuscular monitors. Nowadays, a new technology that allows for the simultaneous acquisition of EMG and AMG signals is commercially available. Although its reliability has been rapidly accepted in Physical Medicine and Rehabilitation, the use of the technique in neuromuscular monitoring has never been reported. The aim of the present study is to assess the validity of the new device for estimating the neuromuscular block by comparing with TOF Watch®-SX, which is the most widely accepted AMG-based neuromuscular monitor that has been practiced in the clinical arena for decades.

Official Title
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Comparison of an Acceleromyography- and Electromyography-based Neuromuscular Monitor With TOF-Watch ® Monitor：a Pilot Study

Conditions
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Neuromuscular Blockade

Intervention / Treatment
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* Device: TOF-Watch®；DELSYS® Wireless surface EMG


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age less than 18 yr American Society of Anesthesiologists Physical Status I to III Elective surgery requiring muscle relaxation Patients participated voluntarily and signed informed consent Exclusion Criteria: Patients with known neuromuscular disorder Stroke Patients with a history of allergic reaction toneuromuscular blocking agents Use of medications that might interfere with neuromuscular transmission Any previous injury to the examined arm that might influence nerve conduction parameters Pacemaker

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: TOF-Watch®；DELSYS® Wireless surface EMG|TOF-Watch® is the most widely accepted AMG-based neuromuscular monitor; and DELSYS® Wireless surface EMG is a new technology that allows for the simultaneous acquisition of EMG and AMG signals in a wireless manner.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Assessing the correlation between the train-of-four (TOF) obtained from the 2 devices |  | Perioperative data | 
| Assessing the correlation between the posttetanic count (PTC) obtained from the 2 devices |  | Perioperative data | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Screening for eligible individual signal sources from the multiplex information of the new technology for improving neuromuscular monitoring |  | Perioperative data | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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neuromuscular blocking agents; residual neuromuscular blockade; neuromuscular monitoring; acceleromyography; electromyography