Randomized Assessment of Rapid Endovascular Treatment in Basilar Artery Occlusion Stroke in 115 Hospital

Study Overview
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Brief Summary
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This is a prospective, open lable studies conducted in 115 hospital to compare between thromboectomy and Recombinant Tisue Plasminogen Activator only to evaluate the eficacy and safety of endovascular treatment in basilar artery occlusion stroke patients

Detailed Description
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Acute basilar artery thrombosis is associated with a poor prognosis. Prevalence of basilar artery occlusion are not known. Although basilar artery occlusion has been reported in 2 per 1000 autopsy cases, basilar artery thrombosis may, in stroke registries, explain as many as 27% of ischemic strokes occurring in the posterior circulation.Various treatments were tried in groups of patients with vertebrobasilar territory infarction but evidence based was not cleared previous studies. Therefore, we conduct this study to evaluate the eficacy and safety of endovascular treatment in basilar artery occlusion stroke patients

Official Title
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Randomized Assessment of Rapid Endovascular Treatment in Basilar Artery Occlusion Stroke in 115 Hospital

Conditions
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Stroke, Acute, Basilar Artery Occlusion

Intervention / Treatment
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* Procedure: Thromboectomy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients admit to 115 hospital in 24h of Basilar Artery Occlusion Stroke NIHSS > 4 points Exclusion Criteria: Patients refuse to participate in studies Patients with contraindication of either rTPA or thromboectomy

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Thromboectomy and rTPA<br>use thromboectomy and rtpa for patient with basilar artery occlusion stroke in 24 hour | Procedure: Thromboectomy<br>* Thromboectomy in Basilar Artery Occlusion patients<br>|
| No Intervention: rTPA( recombinant tissue plasminogen activator )<br>use rtpa for patient with basilar artery occlusion stroke in 24 hour | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| NIHSS in patients wtih Basilar Artery Occlusion Stroke after 24hour admission | NIHSS in patients wtih Basilar Artery Occlusion Stroke after 24hour admission | 24 hours from admission | 
| Survival rate in patients with Basilar Artery Occlusion Stroke | Survival rate in patients with Basilar Artery Occlusion Stroke | 3 months from admission | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| mRS in patients with Basilar Artery Occlusion Stroke | mRS in patients with Basilar Artery Occlusion Stroke | 3 months from admission | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Ischemic stroke, Basilar Artery Occlusion