Blood Pressure Estimation Using Noninvasive Biosignals During Pediatric Anesthesia

Study Overview
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Brief Summary
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The aim of this study is to estimate blood pressure in pediatric patients using a non-invasive electrocardiogram (ECG), photoplethysmograph (PPG), and an accelerometer on the chest.

Detailed Description
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Blood pressure is measured by an automated oscillometric device or arterial waveform from IntelliVue MX800 Bedside patient monitor (Philips Healthcare, Amsterdam, Netherlands). Following parameters will be measured by non-invasive electrocardiogram (ECG), photoplethysmograph (PPG), and an accelerometer on the chest and will be used to estimate the biosignal derived blood pressure. PAT(time between R peak of ECG and beginning of the pulse of PPG) PEP(time between R peak of ECG and peak of accelerometer signal) PTT(PAT-PEP) The algorithm of the biosignal derived blood pressure will be made using the MATLAB 2016b(Mathworks, Natick, MA) program. The agreement between the non-invasive blood pressure and the biosignal derived blood pressure will be analyzed using Cohen's Kappa or Bland-Altman plot.

Official Title
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Blood Pressure Estimation Using Noninvasive Biosignals During Pediatric Anesthesia

Conditions
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Blood Pressure, Pediatrics, Electrocardiography, Accelerometer

Intervention / Treatment
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* Device: Biosignal measurements


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ASA(American Society of Anesthesiologist) Class I, II Scheduled for elective surgery under general anesthesia Exclusion Criteria: History of cardiovascular disease History of thoracic cavity disease Unable to measure blood pressure

Ages Eligible for Study
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Maximum Age: 12 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| biosignal derived blood pressure<br>Blood pressure is measured by an automated oscillometric device or arterial waveform from IntelliVue MX800 Bedside patient monitor (Philips Healthcare, Amsterdam, Netherlands). Following parameters will be measured by non-invasive electrocardiogram (ECG), photoplethysmograph (PPG), and an accelerometer on the chest and will be used to estimate the biosignal derived blood pressure. PAT(time between R peak of ECG and beginning of the pulse of PPG) PEP(time between R peak of ECG and peak of accelerometer signal) PTT(PAT-PEP) | Device: Biosignal measurements<br>* Following parameters will be measured by non-invasive electrocardiogram (ECG), photoplethysmograph (PPG), and an accelerometer on the chest and will be used to estimate the biosignal derived blood pressure. PAT(time between R peak of ECG and beginning of the pulse of PPG) PEP(time between R peak of ECG and peak of accelerometer signal) PTT(PAT-PEP)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Systolic and diastolic Blood pressure | Systolic and diastolic blood pressure by automated oscillometric device or arterial waveform from IntelliVue MX800 Bedside patient monitor (Philips Healthcare, Amsterdam, Netherlands). | During general anesthesia, up to 12 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Electrocardiogram wave | Electrocardiogram wave | During general anesthesia, up to 12 hours | 
| photoplethysmograph wave | photoplethysmograph wave | During general anesthesia, up to 12 hours | 
| accelerometer signal | accelerometer signal | During general anesthesia, up to 12 hours |