Neurodevelopmental Disorders in Children With Congenital Heart Disease

Study Overview
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Brief Summary
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Children with congenital heart disease are at risk for neurodevelopmental disorders, these disorders impacting their quality of life and their integration into society. The aim of this study is to detect neurodevelopmental disorders in children (aged from 6 to 66 months) with congenital heart disease in Nord-Pas-De-Calais (France) and to evaluate the frequency and risk factors of these neurodevelopmental disorders for a better follow-up. This study will help implementing a specific program for the evaluation and management of neurodevelopmental disorders in children suffering from congenital heart disease in Nord-Pas-De-Calais and more globally, in the region Hauts-De-France.

Detailed Description
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Are selected children with significant congenital heart disease (aged from 6 to 66 months) in Nord-Pas-De-Calais fulfilling inclusion criteria. A reliable and valid questionnaire used to screen developmental delays of children aged from one month to 66 months is completed by volunteer parents at the time of the study. Data of the questionnaire is collected and a scoring by professional is provided ; children at risk for neurodevelopmental delays are depicted. In parallel, medical and surgical history is also collected to detect risk factors for neurodevelopmental disorders. The frequency of neurodevelopmental disorders in this screened population according to risk factors (among neonatal data, severity of congenital heart disease, surgery, length of stay at hospital,... ) will be evaluated. The ratio children with neurodevelopmental disorders for whom specific care was implemented/ children with neurodevelopmental disorders who did not have specific care despite neurodevelopmental disorders will be established. Follow-up action will be taken for children at risk for developping neurological disorders highlighted by the screening. This study will help implementing a specific program for evaluation and management of neurodevelopmental disorders for children with congenital heart disease in our region.

Official Title
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Screening for Neurodevelopmental Disorders in Children With Congenital Heart Disease Aged From 6 to 66 Months in Nord-Pas-de-Calais

Conditions
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Congenital Heart Disease

Intervention / Treatment
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* Other: Ages & Stages Questionnaires, Third Edition in French (ASQ-3™)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Children aged 6 to 66 months at the time of study living in region Nord-Pas-De-Calais with  significant congenital heart disease (= complex congenital heart diseases operated or not, simple or moderate congenital heart disease who had cardiac surgery) Followed by the Pediatric Cardiology Department of Lille University Hospital, or patients having a cardiopediatric follow-up outside Lille University Hospital but having been taken in charge at the University Hospital of Lille for any reason (cardiac or not) Exclusion Criteria: Children : lost to sight Deceased with congenital heart disease, living in Nord-Pas-de-Calais but never having been taken in charge at Lille University Hospital with mild or moderate congenital heart disease not having undergone surgery or having only undergone cardiac catheterization with cardiac surgery not performed in the Centers of Jacques CARTIER and Marie LANNNELONGUE

Ages Eligible for Study
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Minimum Age: 6 Months
Maximum Age: 66 Months

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 6 to 66 months children with significant CHD<br>Children with significant congenital heart disease (CHD) aged from 6 to 66 months at the time of the study and fulfilling inclusion criteria for whom an age-appropriate questionnaire completed by parents (Ages & Stages Questionnaires, Third Edition in French (ASQ-3™) will be used to screen developmental delays. | Other: Ages & Stages Questionnaires, Third Edition in French (ASQ-3™)<br>* This questionnaire screens 5 neurodevelopmental areas (communication, gross motor, fine motor, problem solving and personal-social); 30 items per questionnaire about the child's abilities are evaluated. It takes about 15-20 minutes. Data are collecting and a scoring by a professional is provided. Follow-up action is taken for children at risk. Medical and surgical history is also collected to detect risk factors for neurodevelopmental disorders among neonatal data, characteristics of congenital heart disease and first surgery, and other comorbidities.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percentage of children classified at risk for neuro-developmental disorders by the Age & Stage Questionnaire Third Edition in French (ASQ3) score | The ASQ3 evaluates neurodevelopment in children by a parental questionnaire. ASQ-3 score screens 5 neurodevelopmental areas (communication, gross motor, fine motor, problem solving and personal-social); 30 items per questionnaire about the child's skills are evaluated. Each item could be range between Yes (The child do the action - 10 points), Sometimes (5 points) or Not yet (0 point). The scale for each areas could be from 0 (worse outcome) to 60 points (best outcome). The different areas scores are referred in a chart specific of each questionnaire. In each area the score indicates if the child's development appears to be on schedule (best outcome), need learning and attention or need to be evaluated by a professional (worse outcome, - 2 SD from the global population). | Baseline: one session | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Frequency of neurodevelopmental disorders in children with congenital heart disease in this screened population | Number of children depicted with neurodevelopmental delays in comparison to children who do not have neurodevelopmental delays in the screened population | Baseline: one session | 
| Frequency of neurodevelopmental disorders according to the severity of congenital heart disease | Children with neurodevelopmental disorders are classified according to the severity of the congenital heart disease ( mild, moderate or severe congenital heart disease). The percentage of children with neurodevelopmental disorders in each category is established and compared to the others. | Baseline: one session | 
| Number of Children With Documented Risk Factors for neurodevelopmental disorders | The number of children with documented risk factors for neurodevelopmental disorders among neonatal data characteristics of congenital heart disease and first surgery, and comorbidities is evaluated | Baseline: one session | 
| Ratio of children with neurodevelopmental disorders and for whom specific care was implemented | The ratio of children with neurodevelopmental disorders for whom specific care was implemented /children with neurodevelopmental disorders who do not have specific care despite neurodevelopmental disorders is established | Baseline: one session | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Neurodevelopmental disorders,, Congenital heart disease, Children