The Effects of Exercise Training on the Health-related Fitness of Colon Cancer Survivors

Study Overview
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Brief Summary
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Recent studies have suggested that individuals diagnosed with colon cancer who are inactive and/or overweight, may have poorer survival outcomes. Exercise training has been shown to improve fitness and body composition in other cancer survivor groups. The investigators hypothesize that an exercise training program will be a safe, feasible, and effective intervention to improve the fitness and body composition of a group of colon cancer survivors.

Official Title
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The Effects of Exercise Training on the Health-related Fitness of Colon Cancer Survivors: a Randomized Controlled Trial

Conditions
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Colonic Neoplasms

Intervention / Treatment
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* Behavioral: Exercise Training
* Other: Usual Care


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Histologically confirmed Stage II or III colon cancer diagnosis Less than or equal to 1 year since the completion of all adjuvant treatment Negative Physical Activity Readiness Questionnaire (PAR-Q) or completed Physical Activity Readiness Medical Examination (PARmed-X) form 18 years of age or older Ability to understand and provide written informed consent in English Willingness to be randomized Willingness to complete outcome measures at each assessment time point Available for the duration of study intervention period Able to travel to our fitness centre 3/week for the study period Exclusion Criteria: Any absolute contraindication to to exercise testing or training Evidence of active disease (metastatic, recurrent, or unresectable colon cancer) Any uncontrolled medical condition or psychiatric illness that would prevent completion of the exercise program or interfere with the study assessments

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>Exercise | Behavioral: Exercise Training<br>* The exercise group will perform supervised stationary cycle ergometer exercise 3 times per week for 12 weeks and be progressed from 15 to 45 minutes and 60% to 110% of the power output obtained at V02peak. Resistance training will be completed twice per week and will include exercises for all major muscle groups. The training will progress from 60% to 80% of 1RM over the course of the intervention.<br>|
| Other: 2<br>Usual Care, no intervention | Other: Usual Care<br>* Usual Care<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Safety (Monitoring for Adverse Events) |  | 12 Weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Aerobic Capacity |  | Baseline and 12 Weeks | 
| Change in body composition |  | Baseline and 12 Weeks | 
| Feasibility (Adherence to the exercise training program) |  | 12 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Colonic Neoplasms, Aerobic Exercise, Weight Lifting, Body Composition