Study of the Relationship Between Blood Groups,RH and Skeletal Malocclusion : a Cross Sectional Study

Study Overview
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Brief Summary
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the study is searching if there is a relationship between the blood groups and RH and the skeletal malocclusion using the skeletal class I as a control group

Detailed Description
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The study will be conducted on the patients seeking medical care in the orthodontic department Cairo University, for six months all patients with class II and class III malocclusion will be recruited based on Wits appraisal measured from the cephalometric X-ray taken routinely during orthodontic examination. Then a group of class I arch length discrepancy patients will be used as control. A blood sample will be withdrawn and taken to the Cairo university laboratory to analyze the blood group and RH .a statistical analysis will be performed to detect a relationship between skeletal malocclusion and the blood groups as compared to the control

Official Title
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Study of the Relationship Between Blood Groups,RH and Skeletal Malocclusion in a Group of Egyptian Population: a Cross Sectional Study

Conditions
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Class II Malocclusion, Class III Malocclusion

Intervention / Treatment
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* Diagnostic Test: blood type test


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: skeletal class I,II and III patients non syndromic patients above the age of 18 no previous surgical intervention for correction of skeletal malocclusion Exclusion Criteria: syndromic patients cleft patients patients with previous surgery to correct skeletal malocclusion

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| skeletal class II subjects<br>patients with wits appraisal more than 3 mm measured on a cephalometric x ray obtained during diagnosis | Diagnostic Test: blood type test<br>* a blood sample will be withdrawn from the subjects tested by anti A anti B and anti D antigens to detect the individuals blood group and RH. then statistical analysis to detect presence of a relationship between skeletal types of malocclusion and ABO blood groups<br>* Other names: blood typing;|
| skeletal class III subjects<br>patients with wits appraisal less than -3 mm measured on a cephalometric x ray obtained during diagnosis | Diagnostic Test: blood type test<br>* a blood sample will be withdrawn from the subjects tested by anti A anti B and anti D antigens to detect the individuals blood group and RH. then statistical analysis to detect presence of a relationship between skeletal types of malocclusion and ABO blood groups<br>* Other names: blood typing;|
| skeletal class I patients<br>patients with Wits appraisal between -3 and +3 that is measured from a cephalometric x ray obtained during diagnosis of arch length discrepancy. this group will serve as control and obtained after recruitment of the other 2 groups in 1 to 1 fashion | Diagnostic Test: blood type test<br>* a blood sample will be withdrawn from the subjects tested by anti A anti B and anti D antigens to detect the individuals blood group and RH. then statistical analysis to detect presence of a relationship between skeletal types of malocclusion and ABO blood groups<br>* Other names: blood typing;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| relationship between blood group and skeletal malocclusion | If skeletal malocclusion subjects were found to have a high percentage of a certain blood type or RH when compared to the control group it will be reported that there is a relationship between blood group and skeletal malocclusion. If percentages of blood groups are approximately the same in the malocclusion subjects and the control then the investigator will report that there is no relationship between blood groups and skeletal malocclusion | the recruitment will be for six months |