Influence of a Residential Rehabilitation Program on Body Composition in Patients With Cystic Fibrosis

Study Overview
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Brief Summary
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The aim is to evaluate the impact of a 3-week lasting residential rehabilitation program for patients with cystic fibrosis on their nutritional status measured as BMI and body composition and pulmonary function.

Detailed Description
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Cystic fibrosis Patients following a residential rehabilitation program consisting of dietary adaptation, physical therapy for airway drainage and supervised inhalation therapy and physical activity for at least 3 weeks are asked to participate. Weight, height, body composition and pulmonary function will be measured at start and end of the program. Dietary intake during the program is calculated based on a 2 day weighed intake diary and physical activity will be measured with the SenseWear pro 3 armband.

Official Title
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Influence of a Residential Rehabilitation Program on Body Composition in Patients With Cystic Fibrosis (Children and Adults)

Conditions
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Cystic Fibrosis

Intervention / Treatment
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* Other: Rehabilitation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Cystic fibrosis stay at the rehabilitation center for at least 3 consecutive weeks Exclusion Criteria: steroid use absence from the program for more than 2 consecutive days

Ages Eligible for Study
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Minimum Age: 6 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| rehabilitation<br>All included patients get an pre-intervention and a post intervention analysis | Other: Rehabilitation<br>* During the rehabilitation program a multidisciplinary team, consisting of a pneumologist, dietician, psychologist, social worker and several physiotherapists, coach the cystic fibrosis patients. The physiotherapists help with autogenic drainage and aerosol therapy (2-3 times/day) and supervise physical activity (5, 1-hour lasting, training sessions/week: swimming 2, Fitness training 2, 1 session of choice). The dietician calculates basal and theoretical energy needs . A carbohydrate-rich snack before exercise, to improve exercise tolerance and a carbohydrate-protein-rich snack afterwards to improve recuperation is provided.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| body composition change | Dual energy X-ray absorptiometry measured Fat mass index (kg/m*2) | day 0 and day 21 (start and end of the rehabilitation program) | 
| body composition change | Dual energy X-ray absorptiometry measured fat free mass (kg/m*2) | day 0 and day 21 (start and end of the rehabilitation program) | 
| Body mass index change | calculated based on weight and height (kg/m*2) converted in standard deviations | day 0 and day 21 (start and end of the rehabilitation program) | 
| Weight change | Scale weighed weight (kg) converted in standard deviations of normal population of normal populations | day 0 and day 21 (start and end of the rehabilitation program) | 
| pulmonary function change | forced expiratory volume in 1 second (% of normal) | day 0 and day 21 (start and end of the rehabilitation program) | 
| pulmonary function change | Forced Vital capacity (% of normal) | day 0 and day 21 (start and end of the rehabilitation program) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Physical activity | SenseWear pro 3 armband measured physical activity | Week 1 | 
| dietary intake | macronutrient intake measured based on 2 days/week weighed nutritional intake | 2 days/week for 3 consecutive weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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body composition, rehabilitation