Dietary Phosphate and Serum Phosphorus

Study Overview
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Brief Summary
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Overall study design is to review National Health and Nutrition Examination Survey (NHANES) data 1999-2008 for nutrition risk according to kidney function. Substudies will be performed to review the association of nutrients and overall dietary intake compared to biomarkers available in NHANES during this period.

Detailed Description
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Data from NHANES 2003-2006 were used to evaluate the relationship between estimated dietary phosphorus intake and the measured serum phosphorus. The following variables were used: Demographics: Age, sex, race/ethnicity Dietary variables: Foods, food groups (as reported by the United States Department of Agriculture (USDA) method, further standardized to the Academy of Nutrition and Dietetics method for portion size and then divided into groups having inorganic phosphate additives or no inorganic phosphate additives), food weight (g), phosphorus (mg), dietary supplements Socioeconomic variables: education, family income Laboratory variables: serum creatinine, phosphorus; urine albumin, creatinine Clinical assessments: hypertension (proportion having blood pressure ≥140 millimeters of mercury (mmHg) diastolic or ≥90 mmHg systolic or taking antihypertensive medications); hyperglycemia (proportion having serum glucose >126 mg/dL or taking medications for diabetes); kidney function based on Chronic Kidney Disease Epidemiology Collaboration (2009) equation, evaluated in 15 milliliters/min/1.73m2 increments from <15 to >105; anthropometrics (BMI, kg/m2; obesity class I, II, III)

Official Title
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Nutrition Risk Screening in Chronic Kidney Disease (CKD) From the National Health and Nutrition Examination Survey

Conditions
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Phosphorus Metabolism Disorders

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Serum creatinine Exclusion Criteria: Pregnancy No dietary intake interview Dietary intake interview not valid Answered the question Have you had dialysis in the past year? as Yes

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Adults 20-85 years<br>Data from adults 20-85 years old will be evaluated for serum phosphorus concentration. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Serum phosphorus concentration | Serum phosphorus concentration on the day that 24-hour dietary recall was obtained (reflecting dietary intake the day prior to blood draw); measured in mg/dL | approximately 24 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Kidney function level | Kidney function estimated from Chronic Kidney Disease Epidemiology Collaboration (2009) equation, mL/min/1.73m2, and separated into 15mL/min increments | Baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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kidney disease, recommended dietary allowances, nutrition assessment, food, dietary proteins, Vitamin D, dietary fats, ethnology, Continental Population Groups, Phosphorus, dietary, Phosphorus/analysis