The Application of Rapid PTH Test Paper in Operation of Hyperparathyroidism

Study Overview
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Brief Summary
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The half-life of the parathyroid hormone is about 4min, blood pth test is use in operation to confirm that parathyroid tumor is removed. but the blood pth test is time consuming and unpractical in most of hospital. this study will compare the application of rapid PTH test paper in operation of hyperparathyroidism.PTH test were measured in operation in different way. it will test at the time of preoperation, 15 minutes after surgery, 1 hour after surgery and 24 hours after surgery. thus evaluate the reliability and accuracy of PTH test paper in evaluating the Miami principles with the linear relation of blood PTH and the PTH test paper method.

Detailed Description
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Primary hyperparathyroidism is a clinically common disease. At present, the gold standard for determining whether the operation is successful is based on the Miami principle. That means The PTH hormone decreased to 30% of the baseline level after 15min after the tumor was removed. However, due to the differences in PTH monitoring conditions in various hospitals, many hospitals cannot perform rapid PTH monitoring in the operation. Therefore many doctors choose rapid freezing pathology to confirm the lesion., This also led to the inability to evaluate PTH in the presence of multiple lesions,and resulting in the need for reoperations.

Official Title
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The Application of Rapid PTH Test Paper in Operation of Hyperparathyroidism

Conditions
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PTH, Hyperthyroidism, Thyroidectomy, Immunochromatographic

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Primary hyperthyroidism. Secondary hyperthyroidism Unilateral thyroidectomy. Total thyroidectomy and bilateral central compartment dissection Exclusion Criteria: age Older than 70 or younger than 18.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Primary hyperthyroidism<br>Patients diagnosed with primary hyperparathyroidism are prepared for parathyroid surgery. PTH test paper is used addtional at the time point according to Miami principle | |
| Secondary hyperthyroidism<br>Patients diagnosed with Secondary hyperthyroidism are prepared for parathyroid surgery. PTH test paper is used addtional at the time point according to Miami principle | |
| Unilateral thyroidectomy<br>Patients diagnosed with unilateral thyroid benign tumor were prepared for unilateral thyroidectomy. PTH test paper is used addtional at postoperation | |
| thyroidectomy and bilateral CCD<br>Patients diagnosed with bilateral thyroid carcinoma were prepared to undergo total thyroidectomy and bilateral central clearing.PTH test paper is used addtional at postoperation | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Serum PTH | Routine serum PTH test, using immunoluminescence. | 0 minutes, 15 minutes, 1 hour and 24 hours post operation | 
| Serum calcium | Routine serum electrolyte detection. | 0 minutes, 15 minutes, 1 hour and 24 hours post operation | 
| PTH test paper | PTH test paper test for blood | 0 minutes, 15 minutes, 1 hour and 24 hours post operation | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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hyperthyroidism, thyroidectomy, PTH, immunochromatographic assay