Single Versus Combined Antibiotic Therapy for Bacterial Peritonitis in CAPD Patients

Study Overview
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Brief Summary
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To compare the efficacy of single versus combined antibiotic therapy for bacterial peritonitis in CAPD patients.

Detailed Description
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To compare relapse and recurrent rate of peritonitis between single and combined antibiotic regimens for bacterial peritonitis in CAPD patients.

Official Title
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Single Versus Combined Antibiotic Therapy for Bacterial Peritonitis in Continuous Ambulatory Peritoneal Dialysis Patients

Conditions
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Peritonitis

Intervention / Treatment
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* Drug: ceftazidime+ciprofloxacin
* Drug: ceftazidime monotherapy
* Drug: cefazolin+gentamicin
* Drug: cefazolin monotherapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age >/= 18 years old ESRD patients on continuous ambulatory peritoneal dialysis more than 4 weeks presence of symptom or sign of peritonitis presence of WBC >100cell/mm3 with PMN >50% in peritoneal dialysate or gram stain positive for gram positive or gram negative bacteria Exclusion Criteria: presence of polymicrobial organism, non-fermentative gram negative organism, fungus, mycobacteria in peritoneal fluid or culture-negative peritonitis from the organisms that required combined antibiotic therapy according to ISPD guideline 2010 hospital-acquired peritonitis presence of catheter-related infection history of peritonitis within 4 weeks currently taking antibiotic allergic to the antibiotic that used in the study(penicillin or cephalosporin or quinolone or aminoglycoside)

Ages Eligible for Study
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Minimum Age: 15 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: ceftazidime+ciprofloxacin<br>2 synergistic antibiotics(ceftazidime IP and ciprofloxacin po for gram negative bacterial peritonitis) | Drug: ceftazidime+ciprofloxacin<br>* 2 synergistic antibiotics: ceftazidime IP + ciprofloxacin po for gram negative bacterial peritonitis<br>* Other names: combined antibiotic therapy;|
| Active Comparator: ceftazidime monotherapy<br>ceftazidime IP for gram negative bacterial peritonitis | Drug: ceftazidime monotherapy<br>* ceftazidime IP for gram negative bacterial peritonitis<br>* Other names: monotherapy;|
| Experimental: cefazolin+gentamicin<br>cefazolin IP and gentamicin IP for gram positive bacterial peritonitis | Drug: cefazolin+gentamicin<br>* cefazolin IP + gentamicin IP for gram positive bacterial peritonitis<br>* Other names: combined antibiotic therapy;|
| Active Comparator: cefazolin monotherapy<br>cefazolin IP for gram positive bacterial peritonitis | Drug: cefazolin monotherapy<br>* cefazolin IP for gram positive bacterial peritonitis<br>* Other names: monotherapy;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| relapse or recurrent rate |  | within 4 weeks after peritonitis treatment | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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peritoneal dialysis, peritonitis