Prediction of Recurrence and Complications of Nephrolithiasis Using a Precision Medicine Approach

Study Overview
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Brief Summary
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Nephrolithiasis is a disease caused by the formation of kidney stones in the urinary tract which can then partially or completely obstruct the latter causing an extremely sharp pain called renal colic. In industrialized countries, it affects 10 to 20% of the population, and is the most common kidney disease.The primary objective of this study is to identify the clinical, biological, genetic, molecular and environmental determinants predictive of recurrence of renal lithiasis. The study follow-up visit schedule corresponds to the visits usually scheduled as part of patient care: 1 year from the inclusion visit (A1), 3 years (A3) then 5 years (A5). Samples for research (additional volume of blood, urine) will be taken by a registered nurse along with the routine check-up samples.Samples intended for research will be sent by staff to the Biobanque de Picardie (CHU Amiens-Picardie) for processing and conservation.

Official Title
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Prediction of Recurrence and Complications of Nephrolithiasis Using a Precision Medicine Approach

Conditions
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Kidney Stone, Nephrolithiasis

Intervention / Treatment
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* Biological: Blood and urine samples


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adults (≥18 years old), male or female , Persons able to understand and object to the information provided (at the discretion of the investigator) Patient affiliated to social security Patient agreeing to sign the informed consent form patient having presented at least one renal colic attack before inclusion Exclusion Criteria: Pregnant or breastfeeding woman. Persons deprived of liberty, Adults under legal protection guardianship, or curators or unable to express their consent. Patient refusing to participate in the study Patient in an emergency situation

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Screening
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Biological: Blood and urine samples|Additional Blood and urine samples will be collected at inclusion, 1, 3 and 5 years follow up visits|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patients with nephrolithiasis recurrence within 5 years of follow-up |  | at 5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Occurrence of high blood pressure patients |  | at 1 year | 
| Occurrence of high blood pressure patients |  | at 3 years | 
| Occurrence of high blood pressure patients |  | at 5 years | 
| Occurrence of patients with diabetes |  | at 1 year | 
| Occurrence of patients with diabetes |  | at 3 year | 
| Occurrence of patients with diabetes |  | at 5 year | 
| Occurrence of patients with osteopenia | Occurrence of patients with osteopenia during monitoring of bone mineral density with DXA | at 1 year | 
| Occurrence of patients with osteopenia | Occurrence of patients with osteopenia during monitoring of bone mineral density with DXA | at 3 year | 
| Occurrence of patients with osteopenia | Occurrence of patients with osteopenia during monitoring of bone mineral density with DXA | at 5 year | 
| Occurrence of patients with a deterioration in renal function | Occurrence of patients with a deterioration in renal function during follow-up | at 1 year | 
| Occurrence of patients with a deterioration in renal function | Occurrence of patients with a deterioration in renal function during follow-up | at 3 year | 
| Occurrence of patients with a deterioration in renal function | Occurrence of patients with a deterioration in renal function during follow-up | at 5 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Kidney Stone, Nephrolithiasis