Human Papillomavirus (HPV) Types Present in External Genital Warts (EGW) in the Argentinean Population

Study Overview
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Brief Summary
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The summary of this study is to know which HPV types are present in genital warts in Argentinean population.

Detailed Description
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This is a prospective study. Patients will be evaluated for the presence of external anogenital warts in our clinic. Biopsy will be performed if patients have genital lesions consistent with genital warts of the external genitalia or perianal area. All patients will be provided with an informed consent for the excision biopsy procedure, before performing the biopsy of the lesion. Biopsy specimens will be held in a formol 10% solution and will be sent to the pathologist. A portion of each sample will be processed for histological analysis, which will be performed by one pathologist. The remainder of each specimen will be saved to extract DNA for PCR analysis. All biopsies will be analyzed by the same pathologist who will confirm the histology of the lesion. A part of the specimen will be kept frozen and if the biopsy confirm genital warts by histology; then the specimen will be analyzed by PCR for the presence of DNA HPV 6 and 11. The PCR analysis will be done by microarrays. Detection is performed in a subtype of array platform system which detects the different types of virus. The reports will be as undetectable / detectable and type. The study will be conducted in the Institute of Gynecology and Fertility (Institute affiliated with the School of Medicine - University of Buenos Aires). Chronogram of activities: all activities will be done in a maximum of 60 days st visit: detect external genital warts and firm informed consent and take the biopsy nd visit: inform the result

Official Title
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Human Papillomavirus (HPV) Types Present in External Genital Warts (EGW) in the Argentinean Population

Conditions
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Condylomata Acuminata

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: women between 15 and 45 years old, with External Genital Warts Exclusion Criteria: women taking corticoid therapy, having an immunosuppressed disease, pregnancy, cancer related to HPV, VIN confirmed by histology, other sexually transmitted infection, HIV+ known

Ages Eligible for Study
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Minimum Age: 15 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Human Papillomavirus (HPV) Types in External Genital Warts (EGW) | 150 biopsies with histological diagnosis of genital warts were analyzed by PCR to detect HPV type | 4 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Skin Diseases, Viral, genital warts, HPV types, Sexually Transmitted Diseases, Tumor Virus Infections, Skin Diseases, Infectious, Skin Diseases, Papillomavirus Infections, DNA Virus Infections, Virus Diseases, Sexually Transmitted Diseases, Viral