linjc16/ctgov huggingface dataset:
Cyclosporine A in Cardiac Arrest

Study Overview
=================
Brief Summary
-----------------
The investigators hypothesised that cyclosporine A administration at the onset of cardiopulmonary resuscitation, by inhibiting the mitochondrial permeability transition pore, could prevent the post cardiac arrest syndrome and improve outcomes.

Official Title
-----------------
CYclosporine A in Non-shockable Out-of-hospital Cardiac Arrest ResUScitation

Conditions
-----------------
Non Shockable Out of Hospital Cardiac Arrest

Intervention / Treatment
-----------------
* Drug: Cyclosporine A
* Procedure: cardio-pulmonary resuscitation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Witnessed out-of-hospital cardiac arrest Non shockable cardiac rhythm Exclusion Criteria: Evidence of trauma Evidence of pregnancy Duration of no flow more than 30 minutes Rapidly fatal underlying disease Allergy to cyclosporin A

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Cyclosporine A<br>Single intravenous bolus of cyclosporine A (2.5 mg/kg) at the onset of resuscitation | Drug: Cyclosporine A<br>* Single intravenous bolus of cyclosporine A (2.5 mg/kg) at the onset of resuscitation<br>Procedure: cardio-pulmonary resuscitation<br>* usual care of cardiac arrest<br>|
| Active Comparator: Control<br>usual care of cardiac arrest | Procedure: cardio-pulmonary resuscitation<br>* usual care of cardiac arrest<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sequential Organ Failure Assessment score (SOFA) |  | At 24 hours after hospital admission | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hospital admission with return of spontaneous circulation |  | At 24 hours following admission, at day 28, at hospital discharge (an average time frame of 7 days) | 
| Survival |  | At 24 hours following admission, at day 28, and at hospital discharge (an average time frame of 7 days) | 
| Good cerebral outcome | Glasgow Coma Scale and Cerebral Performance Categories | At 24 hours following admission, at day 28, and at hospital discharge (an average time frame of 7 days) | 
| All adverse events |  | until hospital discharge (an average time frame of 7 days) | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Cardiac arrest, heart arrest, cyclosporine A, post cardiac arrest syndrome, protective agent, multiple organ failure, mitochondrial permeability transition pore, mitochondria, cardio-pulmonary resuscitation, cardioprotection, ischemia reperfusion, postconditioning
Parastomal Reinforcement With Strattice

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to compare the clinical outcomes of patients undergoing surgery for a permanent abdominal wall ostomy with and without placement of Strattice fascial inlay, as measured by postoperative occurence of parastomal hernia.

Official Title
-----------------
A Prospective, Multicenter, Randomized, Controlled, Third-party Blinded Study of Strattice Fascial Inlay for Parastomal Reinforcement in Patients Undergoing Surgery for Permanent Abdominal Wall Ostomies

Conditions
-----------------
Parastomal Hernia

Intervention / Treatment
-----------------
* Device: Strattice Reconstructive Matrix
* Other: Standard ostomy creation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: adults need for permanent ileostomy or colostomy Exclusion Criteria: history of hernia at new ostomy site has previously implanted surgical mesh at site of planned ostomy requires a temporary ostomy has need for multiple ostomies is receiving chronic immunosuppression therapy, has MELD score of > 17, has severe COPD, systemic infection, or known collagen disorder is bedridden or otherwise non-ambulatory

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Strattice fascial inlay<br>Strattice will be placed as a fascial inlay to support the ostomy site | Device: Strattice Reconstructive Matrix<br>* Strattice will be placed as a fascial inlay to support stoma sites<br>|
| Other: Standard ostomy construction<br>Ostomy will be created in the standard fashion | Other: Standard ostomy creation<br>* Ostomy will be created as routinely performed<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Occurrence of Parastomal Hernia in Subjects Undergoing Permanent Abdominal Wall Ostomy Creation With and Without Strattice Fascial Inlay. |  | 24 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Stoma Complications |  | 30 days | 
| Stoma Complications |  | more than 1 month postoperatively | 
| Stoma Quality of Life |  | Serially over 24 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Ostomy creation, Parastomal hernia
Strict Glycemic Control by Insulin Infusion:Observations on Emergency Department Initiation

Study Overview
=================
Brief Summary
-----------------
Glycemic control can be safely achieved in surgical and medical intensive care unit settings and has been shown to improve short and long-term clinical outcomes. As such, insulin infusion protocols are routinely used in the ICU setting. The investigators plan to establish the use of strict glycemic control in a heterogenous group of acutely ill patients in the ED setting. The investigators propose to study the aspects of implementing a strict glycemic control protocol in the ED.

Official Title
-----------------
Strict Glycemic Control by Insulin Infusion:Observations on Emergency Department Initiation

Conditions
-----------------
Hyperglycemia

Intervention / Treatment
-----------------
* Drug: Insulin


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with blood glucose ≥130 mg% considered to be critically ill as defined by: APACHE II score ≥9 (See Appendix 1) OR >2 SIRS criteria with lactate ≥ 4 or BP < 90mmHg despite one liter of fluid OR Evidence of Organ Dysfunction (see Appendix 1) Exclusion Criteria: Patients requiring urgent interventional procedure (e.g. cardiac catheterization, dialysis) or surgery performed outside of the ED.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: A<br>All subjects placed on insulin infusion. | Drug: Insulin<br>* Insulin infusion titrated to patients blood glucose to maintain blood glucose between 80-110mg/dL<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time to Achieve Glycemic Control |  | Study duration 6 hours. Blood glucose checked at 30 minutes then every 15 minutes until within target blood glucose range then every hour. | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Hyperglycemia, Glycemic control
A Prospective Study of Application of Platelet Mapping in Chronic Liver Disease Complicated With ALI and/or AD in China

Study Overview
=================
Brief Summary
-----------------
Ineffective hemostasis or a paradoxical prothrombotic state of Acute-on-chronic liver disease (ACLF) has been well established. Thrombelastography measures the dynamics of thrombin production and provides a global assessment of coagulation incorporating the cumulative effect of the interactions at various levels between plasma components and cellular component of coagulation. Through the previous studies(NCT03281278 and NCT04119973), we found that ACLF patients with high ADP inhibition rate had high 28-day mortality.This study aims to validate that high ADP inhibition rate only occurs in patients with liver failure and is related to the severity of the disease.

Official Title
-----------------
A Prospective Study of Application of Platelet Mapping in Chronic Liver Disease Complicated With ALI and/or AD in China

Conditions
-----------------
Thrombelastography, Acute Liver Injury, Acute Decompensation, Platelet

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: chronic liver disease: including chronic liver hepatitis patients without cirrhosis, compensated cirrhosis patients, decompensated cirrhosis patients and non-alcoholic fatty liver disease patients. ALI(acute liver injury): including [ALT > 3 ULN(upper limited of normal),AST > 3 ULN or TB > 2 ULN within 1 week before enrollment] or AD(acute decompensation) : including [(having ascites, hepatic encephalopathy and/or bacterial infection within 1 month before enrollment)]. Exclusion Criteria: those who had hepatocellular carcinoma or other types of malignancies; obstructive biliary diseases or other disease lead to bilirubin evaluation; those who had acute hemorrhage one week before admission those who received platelet, cryo transfusion or plasmapheresis one week before admission pregnancy and breastfeeding those who received liver transplantation or kidney transplantation; combine with other disease lead to organ failure including heart failure (NYHA IV),respiratory failure（PaO2<60mmHg),renal insufficiency(CKD 5) and conscious disturbance (GCS<8) readmission; death within 24 hours.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 28-day mortality | death within 28-day | 28-day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 28-day progression | progressed to EASL defined ACLF | 28-day | 
| 90-day mortality | death within 90-day | 90-day |
Shockwave Lithotripsy (SWL) Under Selective, General Anesthesia.

Study Overview
=================
Brief Summary
-----------------
SWL is widely used in the treatment of patients with renal and ureteral calculi. Several factors determine the success of extracorporeal shockwave lithotripsy (SWL) for kidney stones: stone size, stone location within the collecting system, stone type, and the SWL machine used. Moreover, in some cases it is very difficult to focus on the stone because of its movement as a results of breathing. In order to prevent stone movement we want to use a bronchial blocker, processing a selective ventilation of the opposite side of stone location.

Official Title
-----------------
Shockwave Lithotripsy (SWL) Under Regular General Anesthesia and Under General Anesthesia Using Bronchial Blocker.

Conditions
-----------------
Renal Calculi, Ureteral Calculi

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Older than 18 years old Not pregnant All patients who failed in SWL process, taken under sedation (standard protocol) Exclusion Criteria: Age < 18 Pregnancy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| SWL under general anesthesia<br>Patients who failed in SWL under sedation(a standard protocol), will undergo a second SWL process under general anesthesia. | |
| SWL under general selective anesthesia<br>Patients who failed in SWL under sedation(a standard protocol), will undergo a second SWL process under general selective anesthesia, using a bronchial blocker. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Impact of Anesthetic Environment the Sex Ratio of the Children of Female Assistants

Study Overview
=================
Brief Summary
-----------------
The aims of this multi center retrospective study was to determine: whether the sex ratio of the offspring of female assistants in anesthesia-resuscitation differs from that of the population at large whether the assistants' work environment at the time of their offspring's conception influences the sex of their offspring

Official Title
-----------------
Work Environment's Impact on the Sex Ratio of the Children of Resuscitation Anesthesia Assistants

Conditions
-----------------
Anesthesia, General, Anesthetics Adverse Reaction

Intervention / Treatment
-----------------
* Drug: Anesthetics, Inhalation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Female assistants in anesthesia-resuscitation in the Wallonia-Brussels Federation (Belgium) who conceived one or more children in the course of their training between 2009 and 2019 and who delivered before the end of 2019 (cut-off: midnight on 31 December 2019) Exclusion Criteria: Male assistants in anesthesia-resuscitation Female assistants in anesthesia-resuscitation who trained before 2009 or after 2019. Female assistants in anesthesia-resuscitation who relied on medically assisted reproduction.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Study group<br>All female assistants in anesthesia | Drug: Anesthetics, Inhalation<br>* Work environmental exposure<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Offspring sex ratio | Offspring sex ratio of female anesthesia assistants will be recorded | 5 years (duration of anesthesia training) | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Anesthesia care providers, offspring sex ratio, Inhalation induction of anesthesia
Children Peritonitis Ecology at CHU de Rennes - (IIAPEDIA)

Study Overview
=================
Brief Summary
-----------------
The main objectif is assess the germs (species + antibiograms) implicated in children intra-abdominal infections (community acquired or nosocomial ) at CHU de Rennes.

Official Title
-----------------
Children Peritonitis Ecology at CHU de Rennes - (IIAPEDIA)

Conditions
-----------------
Peritonitis

Intervention / Treatment
-----------------
* Biological: microbiological analysis


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Children between 0 and 18 years old Intra-abdominal infection with and indication for surgery or radiologically guided drainage. No opposition from the child or his parents Exclusion Criteria: No microbiological sampling. Primitive peritonitis (Spontaneous bacterial peritonitis, peritonitis during peritoneal dialysis)

Ages Eligible for Study
-----------------
Minimum Age: 1 Day
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Biological: microbiological analysis|microbiological analysis of the peritoneal fluid|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood Culture | Ecology (germs resistance profile) | 2 weeks after inclusion |
Optimal Passive Dilation Time in Retrograde Intrarenal Surgery

Study Overview
=================
Brief Summary
-----------------
Retrograde intrarenal surgery (RIRC) is used as standard treatment for stones less than 2 cm. In some cases, the ureteral access sheath cannot be placed due to ureteral stricture. In this case, a double j stent (DJ) is placed to passively dilate the ureter, and the RIRC is postponed for post-dilatation. The aim of the study is to determine the optimal time for RIRC operation in cases where a double j stent was placed for passive dilatation.

Official Title
-----------------
Optimal Passive Dilation Time in Retrograde Intrarenal Surgery

Conditions
-----------------
Stone, Kidney, Urolithiasis

Intervention / Treatment
-----------------
* Procedure: Retrograde intrarenal surgery after DJ stent placement


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with a DJ stent for passive dilatation and subsequent RIRC Exclusion Criteria: Urinary tract infection, patients with ureteral compression and a history of pelvic radiotherapy, urinary system tumor

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients who underwent RIRC for 2-4 weeks after DJ stent placement for passive dilatation<br>Patients who underwent RIRC for 2-4 weeks after DJ stent placement for passive dilatation | Procedure: Retrograde intrarenal surgery after DJ stent placement<br>* Patients who underwent RIRC for 2-4 weeks after DJ stent placement for passive dilatation<br>|
| Patients who underwent RIRC for 4-6 weeks after DJ stent placement for passive dilatation<br>Patients who underwent RIRC for 4-6 weeks after DJ stent placement for passive dilatation | Procedure: Retrograde intrarenal surgery after DJ stent placement<br>* Patients who underwent RIRC for 2-4 weeks after DJ stent placement for passive dilatation<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| BMI in kg/m^2 | BMI in kg/m^2the kidney, operation time(minute) | 3 Months | 
| serum creatinine mg/dl | serum creatinine mg/dl | 3 Months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| mm size of the stone | mm size of the stone | 3 Months | 
| localization of the stone in the kidney, | localization of the stone in the kidney, | 3 Months |
Prevalence of Colon Cancer in Pyogenic Liver Abscess

Study Overview
=================
Brief Summary
-----------------
Although a proportion of pyogenic liver abscess may originated from colonic mucosal lesions, the prevalence of colonic neoplasm in the patients with pyogenic liver abscess are still not evaluated yet. Thus, our group will find the prevalence of colonic neoplasm in the group of cryptogenic pyogenic liver abscess by colonoscopic examination.

Official Title
-----------------
The Prevalence of Colonic Neoplasm in Cryptogenic Pyogenic Liver Abscess

Conditions
-----------------
Cryptogenic Pyogenic Liver Abscess

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Pyogenic liver abscess radiologically and bacteriologically diagnosed Exclusion Criteria: Amebic liver abscess Other causes of pyogenic liver abscess such as cholangitis, liver cancer, complication of transarterial chemoembolization or radiofrequency ablation to hepatocellular carcinoma Refusal to colonoscopic examination Inadequate general patient status to perform the colonoscopic examination Patient who has had the screening colonoscopic examination within 1 year and showed normal finding or had 1 or 2 colon polyp in adequate exam

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Colonoscopic examination group<br>The patients diagnosed with cryptogenic pyogenic liver abscess | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The prevalence of colonic neoplasm |  | within 6 weeks after diagnosis of pyogenic liver abscess | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prevalence of colon polyp |  | Within 6 weeks at diagnosis of pyogenic liver abscess | 
| Prevalence of colonic diverticulitis |  | Within 6 weeks at diagnosis of pyogenic liver abscess | 
| Prevalence of inflammatory bowel disease |  | Within 6 weeks at diagnosis of pyogenic liver abscess | 
| Prevalence of intestinal tuberculosis |  | Within 6 weeks at diagnosis of pyogenic liver abscess | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
pyogenic liver abscess, colon cancer