Desflurane and Sevoflurane Minimal Flow Anesthesia on Recovery and Anesthetic Depth

Study Overview
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Brief Summary
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Minimal flow anesthesia has economic and environmental advantages in addition to providing earlier recovery following general anesthesia. There is a paucity of data concerning the effect of minimal flow anesthesia (fresh gas flow <0,5 l/min) on recovery parameters. The primary objective of this study is to compare the recovery parameters of desflurane and sevoflurane in minimal flow anesthesia while the secondary objective is to compare the effect of these agents on anesthetic depth using bispectral index.

Official Title
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Comparison of Desflurane and Sevoflurane Minimal Flow Anesthesia on Recovery Parameters and Anesthetic Depth: a Randomized Prospective Study

Conditions
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Anesthesia

Intervention / Treatment
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* Procedure: Minimal flow anesthesia (fresh gas flow <0.5 l/min) using Sevoflurane
* Procedure: Minimal flow anesthesia (fresh gas flow <0.5 l/min) using Desflurane


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Ages between 18 and 65 Patients undergoing elective surgery under general anesthesia Patients with an American Society of Anesthesiologists Classification I or II Exclusion Criteria: Patient refusal Emergency surgery Patients with a contraindication for minimal flow anesthesia Uncontrolled diabetes mellitus History of serious systemic disease (cardiac, pulmonary, hepatic) Utilization of another analgesic technique such as central or peripheral nerve blocks

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Group Sevoflurane<br>The patients in this arm will be given Sevoflurane (2-3%) as volatile anesthetic throughout the duration of anesthesia. | Procedure: Minimal flow anesthesia (fresh gas flow <0.5 l/min) using Sevoflurane<br>* Sevoflurane will be used for the maintenance of general anesthesia which will be carried out using a fresh gas flow of less than 0,5 l/min<br>|
| Active Comparator: Group Desflurane<br>The patients in this arm will be given Desflurane (7-8%) as volatile anesthetic throughout the duration of anesthesia. | Procedure: Minimal flow anesthesia (fresh gas flow <0.5 l/min) using Desflurane<br>* Desflurane will be used for the maintenance of general anesthesia which will be carried out using a fresh gas flow of less than 0,5 l/min<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time until extubation | Time interval between discontinuation of the volatile anesthetics and removal of the endotracheal tube | Up to 10 minutes after discontinuation of the volatile anesthetic | 
| Time until eye opening | Time interval between discontinuation of the volatile anesthetics and eye opening with verbal command | Up to 20 minutes after discontinuation of the volatile anesthetic | 
| Time until transfer readiness | Time interval between discontinuation of the volatile anesthetics and Aldrete score reaching 9 or greater | Up to 45 minutes after discontinuation of the volatile anesthetic | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Anesthetic depth provided by the volatile anesthetic | Anesthetic depth as measured by Bispectral Index | Change in Bispectral Index values at 5, 10, 15, 30, 60 and 120 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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general anesthesia, low flow anesthesia, sevoflurane, desflurane