Nano Fat Injection With or Without Fractional Carbon Dioxide Laser in Acne Scars

Study Overview
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Brief Summary
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Assessment of nano fat grafting combined with carbon dioxide laser resurfacing versus nano fat grafting alone in treating facial atrophic acne scars

Detailed Description
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Acne scars is a world wide problem .though lots of treatment exists still mo gold standard for treatment of acne scars in this study. Assessment of nano fat grafting combined with carbon dioxide laser resurfacing versus nano fat grafting alone in treating facial atrophic acne scars

Official Title
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Assessment of Nano Fat Grafting Combined With Fractional Carbon Dioxide Laser Resurfacing Versus Nano Fat Grafting Alone in Atrophic Facial Acne Scars

Conditions
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Acne Scars - Atrophic

Intervention / Treatment
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* Procedure: Fat grafting


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients older than 18 years who attend the Outpatient Clinics of Dermatology and Plastic Surgery Departments, Assiut University Hospital, with moderate to severe atrophic facial acne scars on both cheeks, as assessed using the Goodman and Baron Qualitative scar grading system (12), will be enrolled in the study. Exclusion Criteria: include: pregnancy or lactation; active acne, history of deep chemical peeling or filler injection in the previous 6 months, history of keloid or hypertrophic scar formation; use of isotretinoin in the previous 6 months; active infection in the treatment area; bleeding tendencies; history of herpes simplex or herpes zoster infection on the face; and patients with unrealistic expectations.

Ages Eligible for Study
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Minimum Age: 16 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Nano fat grafting and fractional carbon dioxide laser resurfacing<br>treating of atrophic acne scars with nano fat and fractional carbon dioxide laser | Procedure: Fat grafting<br>* Nano fat grafting followed by fractional carbon dioxide laser resurfacing<br>* Other names: fractional carbon dioxide laser resurfacing;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical assessment of acne scar severity | as assessed using the Goodman and Baron Qualitative scar grading system before and after treatment on both sides of face, to determine the number of patients achieving two grades improvement vs one grade or no improvement | up to 24 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Physician global assessment | two blinded observers will compare the before and after photographs separately on each facial side and will evaluate the improvement on a quartile grading scale as: poor,<25% improvement; fair, 25%-50% improvement; good, 51%-75% improvement; and excellent, >75% improvement. | up to 24 weeks | 
| percent of reduction in scar count | count of the total and different types of acne scars was performed, before and after treatment on both sides of the face, and the percent of reduction was calculated | up to 24 weeks | 
| Patient satisfaction | Patients will rate their overall satisfaction on a quartile grading system: 0, unsatisfied; 1, slightly satisfied; 2, satisfied; and 3, very satisfied | 1 year | 
| Adverse events | erythema, edema, crusting, pigmentary changes, ecchymosis, and scarring, will be recorded | 1 year |