French Observatory on the Management of Cardiogenic Shock in 2016

Study Overview
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Brief Summary
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Cardiogenic shock (CS) is defined as an organ hypoperfusion secondary to low cardiac output. Catches diagnostic management, and therapeutic monitoring of these patients remain highly variable from one center to another and even from one doctor to another within the same team. The management protocols are often not standardized or non-existent. It appears therefore necessary to make an inventory of the management practices of the CS in France in 2016, prerequisite to a common work of standardization of practices and the creation of specialized networks to support these complex patients.

Detailed Description
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The Observatory FRENSHOCK proposes to set up a cohort of 500 patients recruited prospectively over a period of 6 months. Patients will be followed up at 1 month and 1 year Patients should have agreed to participate in the observatory, knowing that participation or refusal to participate will not alter the therapeutic attitude of the physician responsible for the patient. The study of phenotypic characteristics will not change the therapeutic approach of the medical teams.

Official Title
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French Observatory on the Management of Cardiogenic Shock in 2016

Conditions
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Shock, Cardiogenic

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Informed consent Cardiogenic shock authenticated by the existence of at least one positive test for each of the following three parts: (A) Low cardiac output (1 criterion necessary and sufficient): Clinic: SBP <90mmHg and / or need to maintain inotropic or vasopressor to maintain SBP> 90 mmHg Echocardiography: IC <2.2L / min / m2 and / or LVEF <30% Hemodynamics by Swan Ganz catheterization or right: IC 2.2 l / min / m2 (B) elevation of pulmonary pressure / left surcharge (1 criterion necessary and sufficient): Clinical (IVD and abortion); Radiological (Surcharge on RT or chest CT); Organic (NTproBNP> 900pg / ml or BNP> 400pg / ml); Echocardiography (E / A> 2 if LVEF <45% or E / Ea> 13 if normal LVEF, or PAPS> 35mmHg and / or TDE <150ms and / or Ap-Am> 30ms and / or E / 2 Vp≥ , 5); Right Swan Ganz catheterization or (pulmonary capillary pressures> 15mmHg and / or mPAP> 25mmHg) (C) Organs malperfusion (1 criterion necessary and sufficient): Clinic: oliguria <30ml / kg / h, mottling, consciousness disorders) Organic: arterial lactate> 2 mmol / L, liver failure, kidney failure Exclusion Criteria: Final diagnosis retained other than cardiogenic shock Cardiac arrest without spontaneous activity in the hospital management Post-cardiotomy cardiogenic shock Deprived of liberty patient Refusal or lack of consent

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cardiogenic shock<br>Patient with cardiogenic shock table defined by the combination of a low cardiac output even as the filling pressures are normal or high, originally of hypoperfusion and organ suffering. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality at day 30 | Death rate at 30 days of follow-up | 30 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Analysis of mortality at day 30 by subgroup on age, sex, NYHA grade, initial etiology | Rate of mortality at day 30 distributed by subgroup on age, sex, NYHA grade, initial etiology (Including ischemic versus non-ischemic heart disease, type and assistance and medical treatment) | 30 days | 
| Mortality at 1 year | Death rate at 1 year of follow-up | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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cardiogenic shock, observatory