Mitochondrial Functions and Oxidative Stress in ALS Patients

Study Overview
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Brief Summary
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In Amyotrophic Lateral Sclerosis (ALS), malnutrition is frequent (16 to 50 % of the patients) and is an independent prognostic factor. One of the implicated factors is the increase of resting energy expenditure (REE) which can be found in about 50 % of ALS patients. The origin of this hypermetabolism is currently unknown but could be located in the mitochondria. In fact, some studies have found mitochondrial abnormalities and the existence of an oxidative stress. Thus, the aim of this study is to characterize the mitochondrial abnormalities and the oxidant/antioxidant status of ALS patients and to determine their relationship with the metabolic status, hypermetabolism or normometabolism. Three groups of patients will be studied : 20 hypermetabolic ALS patients, 20 normometabolic ALS patients and 20 healthy volunteers paired for age and sex.

Detailed Description
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In Amyotrophic Lateral Sclerosis (ALS), malnutrition is frequent (16 to 50 % of the patients) and is an independent prognostic factor. One of the implicated factors is the increase of resting energy expenditure (REE) which can be found in about 50 % of ALS patients. The origin of this hypermetabolism is currently unknown but could be located in the mitochondria. In fact, some studies have found mitochondrial abnormalities and the existence of an oxidative stress. Thus, the aim of this study is to characterize the mitochondrial abnormalities and the oxidant/antioxidant status of ALS patients and to determine their relationship with the metabolic status, hypermetabolism or normometabolism. Three groups of patients will be studied : 20 hypermetabolic ALS patients, 20 normometabolic ALS patients and 20 healthy volunteers paired for age and sex.

Official Title
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Study of Mitochondrial Functions and Oxidative Stress in ALS Patients.

Conditions
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Amyotrophic Lateral Sclerosis

Intervention / Treatment
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* Procedure: Mitochondrial functions and oxidative stress


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: male or female age > 30 years definite or probable ALS according to the El Escorial criteria, bulbar or spinal form, ALS diagnosis < 1 year and treatment by riluzole. Exclusion Criteria: family history of ALS, oral, enteral or parenteral nutritional supply, vitamin or trace element supplementation confusing illness (cancer, diabetes, chronic infectious or inflammatory disease,thyroid disorders, recent surgery...), current tobacco use, alcoholism treatment by corticosteroids, diuretics, anorectics NSAIDs cytotoxics anticoagulants...

Ages Eligible for Study
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Minimum Age: 30 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Mitochondrial functions and oxidative stress|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| relationship between these abnormalities and the metabolic status (hypermetabolism or normometabolism). |  |  | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Hypermetabolism, Mitochondrial abnormalities, Oxidant/antioxidant status