Is Sheep Ghee Cardioprotective?

Study Overview
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Brief Summary
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Normal volunteers were randomly received Sheep ghee or sunflower oil, and before and after the study lipid profile and HS-CRP were measured.

Detailed Description
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During outpatient clinic visits, potentially eligible individuals were screened for enrollment according to the inclusion and exclusion criteria. Patients were randomly allocated into the treatment and control groups via the blocked randomization method. The control group received a normal diet for eight weeks with 10 g of sunflower oil. In the treatment group, sunflower oil was replaced with 10 g of sheep ghee. 50 patients in each group were enrollment. Patients' information, including demographic data and the serum levels of fasting blood sugar (FBS), LDL, HDL, triglyceride (TG), and hs-CRP, were recorded in datasheets twice: once before treatment with sheep ghee and once eight weeks later.

Official Title
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Effect of Sheep Ghee on Lipid Profile and High-sensitivity C-reactive Protein: A Randomized Clinical Trial

Conditions
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Inflammation, Cholesterol; Metabolic Disorder

Intervention / Treatment
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* Dietary Supplement: sheep ghee
* Dietary Supplement: sunflower oil


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: healthy adults, seeking outpatient visit at professor kojuri cardiology clinic Exclusion Criteria: any history of ischemic heart disease (IHD), coronary artery bypass grafting (CABG) percutaneous intervention (PCI) stroke peripheral vascular diseases use of anti-hyperlipidemic agents unwillingness to participate. Need of tight hyperlipidemia control.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 76 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: clinical trial randomized
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: intervention<br>10 gr Sheep ghee | Dietary Supplement: sheep ghee<br>* natural sheep ghee, given to patient in a commercial box and intervention group 10 gr per day from sheep ghee<br>|
| Active Comparator: control group<br>10 gr sunflower oil | Dietary Supplement: sunflower oil<br>* natural sunflower oil, given to patients in a commercial box and patient use 10 gr of it<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| LDL cholesterol | serum LDL level in mg/dl | 2 months | 
| total cholesterol | serum total cholesterol in mg/dl | 2 months | 
| HDL cholesterol | Serum HDL in mg/dl | 2 months | 
| HS-CRP | HS-CRP level in picogram/dl | 2 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| adverse effect | gastrointestinal, skin, allergy | 2 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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sheep ghee, Atherosclerosis, cardiovascular disease, high-sensitivity C-reactive protein, inflammation