IUI Schedule in Cases of High Progesterone

Study Overview
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Brief Summary
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Intrauterine insemination (IUI) combined with ovarian stimulation protocols has become one of the first alternative treatment against infertility, although results in gestational terms are highly variable, ranging between 10% and 25%. The influence of progesterone levels in stimulated cycles of intrauterine insemination is an aspect little studied; however, this information may be useful when synchronizing the time of insemination with the implantation window, as it has been observed that patients with elevated levels of progesterone in the follicular phase exhibit a significant decrease in ongoing pregnancy rates, these results being possible due to premature ovulation which causes asynchrony between the embryo and the endometrium. Taking into account these considerations, the aim of the investigators' study is to determine the effectiveness, in terms of ongoing pregnancy rates, to advance the intrauterine insemination with sperm donor (24 hours post-hCG) with respect to the standard schedule (36 hours post-hCG) according progesterone levels determined the day of hCG administration

Detailed Description
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Correct schedule of intrauterine insemination is essential to the success of these treatments due to the limited range in which the capacitated sperm survive the female genital tract and oocytes can be fertilized after ovulation. For intrauterine insemination, the fraction of motile sperm is injected directly into the uterine cavity and later migrate into abdominal cavity, where they remain a few hours after insemination; meanwhile, fertilizable oocytes are only between 12-16 hours after ovulation. In the cycles in which follicular growth is monitored, a spontaneous LH surge before ovulation induction with HCG is a possibility; indeed, in stimulated cycles LH is not usually determined so clinicians are not able to know if there has been or not ovulation. Ovulation usually occurs 24 hours after the LH surge; therefore, an insemination performed 36 hours after ovulation induction may be too late in cases of premature ovulation. The influence of progesterone levels in stimulated cycles of intrauterine insemination is an aspect little studied; however, this information can be useful when synchronizing the time of insemination with the implantation window. The day of ovulation induction, the investigators will determine progesterone levels. If progesterone> 1 ng / ml the patient be randomized in one of the following groups: Group 1 (intrauterine insemination with sperm donor IAD at 36 hours post-hCG). Cases where the IAD is scheduled at 36 hours post-administration of hCG. Group 2 (IAD at 24 hours post-hCG). Cases where the IAD is scheduled at 24 hours post-administration of hCG.

Official Title
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Programming IUI With Sperm Donor in Patients With High Progesterone the Day of hCG Administration

Conditions
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Infertility

Intervention / Treatment
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* Other: IAD at 36 hours
* Other: IAD at 24 hours


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Body mass index (BMI) 18-30 kg / m2 Patent tubes Regular cycles (26-35 days) FSH levels on day 3 of cycle (<10 mIU / ml) Estradiol levels on day 3 of cycle (<60 pg / ml) Progesterone levels the day of hCG (> 1 ng / ml) Semen donors belonging to the bank of IVI Exclusion criteria Patients with ≥3 follicles of over 16 mm diameter No dominant follicle after two consecutive ultrasound Women with P <1 ng / ml on the day of hCG

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Group 1<br>Intrauterine insemination with sperm donor (IAD) at 36 hours post-hCG. Cases where the IAD is scheduled at 36 hours post-administration of hCG. | Other: IAD at 36 hours<br>* Intrauterine insemination with sperm donor at 36 hours post-hCG<br>|
| Experimental: Group 2<br>Intrauterine insemination with sperm donor (IAD) at 24 hours post-hCG. Cases where the IAD is scheduled at 24 hours post-administration of hCG. | Other: IAD at 24 hours<br>* Intrauterine insemination with sperm donor at 24 hours post-hCG<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ongoing pregnancy rate |  | 1 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Doses of gonadotropins |  | 1 day | 
| Estradiol levels the day of hCG administration |  | 1 day | 
| LH levels the day of hCG administration |  | 1 day | 
| Days of stimulation |  | 1 day | 
| Cancellation rate |  | 1 month | 
| Pregnancy rate |  | 1 month | 
| Miscarriage rate |  | 1 month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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intrauterine insemination, progesterone