Respiratory Function at Preschool Age of Children Detected of Cystic Fibrosis in Neonatal Period

Study Overview
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Brief Summary
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The widespread neonatal detection of cystic fibrosis in France since 2002 permits to treat children from birth. New treatments used for young children involve to assess efficacy criteria specific to this population. Standard respiratory function criteria for older children and adults is forced expiratory volume/second. This technique is not suited for preschool aged children (3 to 6 years old) because they are too old to be sedated and too young and immature to be able to make forced expiration technique that are correct, reproducible and prolonged during more than 1 second. For preschool aged children, in order to assess distal damage and her consequence, the evaluations are: airway resistance by debit interruption technic (Rint), plethysmographic measure of specific resistance (sRaw), functional residual capacity by Helium dilution technique (CRF He), arterial blood gas measurement, pulmonary clearance index. All these methods have a better success rate and can be used in alternative or with forced spirometry. However, each of them gives only a part of information on airway and lung damage of detected children. It is necessary to combine them for a better information on overall respiratory damage. In France, each respiratory function test laboratory uses one or any of these methods in addition to flow-volume curve, in function of his practices and his equipment. So, respiratory function test of preschool aged children is going to diversify more and more to the detriment of an homogeneity of practices between different centers. A referent population during a longitudinal multicenter monitoring on large cohorts that describe the evolution of pulmonary function, obtained by a standardized methodology is necessary to assess the efficacy of any new treatment. And, with the homogenization of care of children detected of cystic fibrosis in different centers, the description of natural evolution of pulmonary function by a standardized methodology will improve the discriminative power of measure of respiratory function to assess the presence of a worsening in preschool-aged children.

Conditions
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Cystic Fibrosis

Intervention / Treatment
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* Other: 3 years-assessment of respiratory function


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient suffering from cystic fibrosis Height between 90 et 130cm No respiratory exacerbation since 4 weeks Benefit from an insurance disease regime Exclusion Criteria: Law-protected patient Patient's parent don't understand french language Opposition to participation
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Preschool aged children detected of CF in neonatal period<br>Preschool aged children detected of Cystic Fibrosis in neonatal period | Other: 3 years-assessment of respiratory function<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time evolution of functional residual capacity by Helium dilution technique (CRF He) |  | at each four yearly routine visits | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| airway resistance by debit interruption technique (Rint) |  | at each four yearly routine visits | 
| plethysmographic measure of specific resistance (sRaw) |  | at each four yearly routine visits | 
| arterial blood gas measurement |  | at each four yearly routine visits | 
| pulmonary clearance index |  | at each four yearly routine visits | 
| flow-volume curve |  | at each four yearly routine visits | 
| measurement of organ damage |  | at each four yearly routine visits | 
| measurement of tobacco exposition |  | at each four yearly routine visits | 
| measure of administration antibiotics and antiasthmatics treatments | Comparison of the evolution of these parameters to changing those of a historical cohort evaluated before the introduction of neonatal screening. | at each four yearly routine visits | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Time evolution of respiratory function, Longitudinal multicenter monitoring of large cohorts, Preschool aged children, Detection of cystic fibrosis in neonatal period