Sprint Interval Training on the Endurance, Strength and Velocity Capacities of Healthy Sedentary Subjects

Study Overview
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Brief Summary
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The present study aims to analyse first, the acute effects generated by a single bout of Sprint Interval Training (SIT) and, secondly, the effects of a long-term intervention on sedentary participants.

Detailed Description
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The main goal is to determine the optimal dose of high-intensity exercise that enhances the best physiological adaptations. The cumulative effects of SIT, will be assessed by a series of measures placed throughout the time-course (before, after the 1st , the 2nd and the 3rd block of SIT). Those measures consist of physiological measurements (VO2max), neuromuscular capacities (force-velocity profile) the autonomic nervous system responses (heart rate variability) and blood markers (lactate, Creatine phosphoKinase (CK), cytokinases, µRNA). Acute effects will be measured in the familiarisation sessions (after short (8 sprints) and long (14 sprints) sets) by performing a battery of neuromuscular, perceptual, and autonomic nervous system tests before and after the single session of SIT.

Official Title
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Sprint Interval Training (SIT) on the Endurance, Strength and Velocity Capacities of Healthy Sedentary Subjects

Conditions
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Sedentary Behavior

Intervention / Treatment
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* Other: Sprint Interval Training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: untrained healthy (less than 2 hours of sport per week) free from muscular, bone or joint injuries free from neurologic disease Exclusion Criteria: taking neuroactive substances that can alter corticospinal excitability Heart or respiratory failure. Subjects who have taken corticosteroids within 3 months (inhalation, infiltration or history of corticosteroid therapy). Pregnant woman Subject under guardianship

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Interventional Model Description: Sedentary participants
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Sedentary participants<br>Series of measures placed throughout the time-course (before, after the 1st , the 2nd and the 3rd block of SIT). These measurements consist of physiological measurements (VO2max), neuromuscular capacities (force-speed profile), autonomic nervous system responses (heart rate variability) and blood markers (lactate, CK, cytokinases, µRNA). | Other: Sprint Interval Training<br>* The Sprint Interval Training (SIT) training consists of 3 successive blocks of 5 training sessions each. The sessions are 24 to 48 hours apart. . One block lasts two weeks. After the end of one block, the following block begins the day after. The Sprint Interval Training lasts 6 weeks. Each session consists of a series of sprints, the number of which varies from 8 to 14. Thus a session will last from 30 to 45 min approximately So, the time frame of this study is Baseline, Block 1, Block 2 and Block 3 (Not in day or week or month)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| oxygen uptake (VO2max) - ml/min/kg | consumption oxygen uptake (VO2max) measured on a cycle ergometer The main objective is to determine at which time frame of sprint interval training blocks, the endurance performance (VO2max) is best. | At the end of the 1st, 2nd and 3rd block : Each block = 2 weeks; each block is 1 day apart | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Maximum power (W) | It is measured thanks to the force-speed profile using two sprints of 7s with braking forces of 0 , 4 and 0.7 N.kg-1 respectively. | At the end of the 1st, 2nd and 3rd block : Each block = 2 weeks; each block is 1 day apart | 
| Maximum theoretical force (N.m) | It is measured thanks to the force-speed profile using two sprints of 7s with braking forces of 0 , 4 and 0.7 N.kg-1 respectively. | At the end of the 1st, 2nd and 3rd block : Each block = 2 weeks; each block is 1 day apart | 
| Maximum theoretical speed (m/s) | It is measured thanks to the force-speed profile using two sprints of 7s with braking forces of 0 , 4 and 0.7 N.kg-1 respectively. | At the end of the 1st, 2nd and 3rd block : Each block = 2 weeks; each block is 1 day apart | 
| Maximum isometric force (N.m) | It is measured by means of a voluntary maximum contraction test in which the maximum force generated voluntarily is compared to that voluntarily generated force will be compared to that evoked using electrical stimulation of the femoral nerve. | At the end of the 1st, 2nd and 3rd block : Each block = 2 weeks; each block is 1 day apart | 
| heart rate variability (HRV) |  | At the end of the 1st, 2nd and 3rd block : Each block = 2 weeks; each block is 1 day apart | 
| Lactate (mmol/l) | Blood sample | At the end of the 1st, 2nd and 3rd block : Each block = 2 weeks; each block is 1 day apart | 
| Cytokines (pg/ml) | Blood sample | At the end of the 1st, 2nd and 3rd block : Each block = 2 weeks; each block is 1 day apart | 
| Creatine Kinase (UI/l) | Blood sample | At the end of the 1st, 2nd and 3rd block : Each block = 2 weeks; each block is 1 day apart | 
| muscle microRNA | Blood sample | At the end of the 1st, 2nd and 3rd block : Each block = 2 weeks; each block is 1 day apart | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Sprint Interval Training, VO2max, acute fatigue, chronic fatigue, force-velocity profile