Imatinib Mesylate and Capecitabine in Treating Patients With Advanced Solid Tumors

Study Overview
=================
Brief Summary
-----------------
RATIONALE: Imatinib mesylate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Drugs used in chemotherapy, such as capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving imatinib mesylate together with capecitabine may kill more tumor cells. PURPOSE: This phase I trial is studying the side effects and best dose of imatinib mesylate when given together with capecitabine in treating patients with advanced solid tumors.

Detailed Description
-----------------
OBJECTIVES: Primary Determine the maximum tolerated dose and recommended phase II dose of imatinib mesylate when administered with capecitabine in patients with advanced malignant solid tumors. Secondary Determine the non-dose-limiting toxic effects of this regimen in these patients. Determine, preliminarily, the clinical activity of this regimen in these patients. Determine the pharmacokinetics and pharmacogenetics of this regimen in these patients. Determine, preliminarily, the effect of this regimen on wound angiogenesis in these patients. Correlate pharmacokinetic parameters with clinical toxicity, clinical activity, or surrogate biomarker activity of this regimen in these patients. OUTLINE: This is a dose escalation study of imatinib mesylate. Patients receive oral capecitabine twice daily on days 1-14 and oral imatinib mesylate once or twice daily on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. Cohorts of patients receive escalating doses of imatinib mesylate until the maximum tolerated dose is determined. PROJECTED ACCRUAL: A total of 42 patients will be accrued for this study.

Official Title
-----------------
A Phase I Dose Escalation Study of Imatinib Mesylate (Gleevec/STI571) Plus Capecitabine (Xeloda) in Advanced Solid Tumor Malignancies

Conditions
-----------------
Unspecified Adult Solid Tumor, Protocol Specific

Intervention / Treatment
-----------------
* Drug: capecitabine
* Drug: imatinib mesylate


Participation Criteria
=================
Eligibility Criteria
-----------------
DISEASE CHARACTERISTICS: Histologically confirmed malignant solid tumors for which no standard effective therapy exists OR such therapy is refused Previously treated brain metastases that are currently asymptomatic allowed PATIENT CHARACTERISTICS: Performance status Karnofsky 70-100% Life expectancy Not specified Hematopoietic Absolute neutrophil count > 2,000/mm^3 Platelet count > 100,000 mm^3 Hemoglobin > 9.0 g/dL Hepatic Alkaline phosphatase < 2.5 times upper limit of normal (ULN) SGOT and SGPT < 2.5 times ULN Bilirubin < 1.5 times ULN Renal Creatinine clearance > 50 mL/min Cardiovascular No congestive heart failure No symptomatic coronary artery disease No uncontrolled cardiac arrhythmias No myocardial infarction within the past 12 months No other clinically significant cardiac disease Other Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception during and for 3 months after completion of study treatment No prior unanticipated severe reaction to fluoropyrimidine therapy No known sensitivity to fluorouracil PRIOR CONCURRENT THERAPY: Biologic therapy More than 28 days since prior biologic therapy Chemotherapy More than 28 days since prior chemotherapy (42 days for nitrosoureas or mitomycin C) Endocrine therapy At least 90 days since prior steroids for the treatment of brain metastases More than 28 days since prior hormonal therapy Radiotherapy At least 90 days since prior radiotherapy for the treatment of brain metastases More than 28 days since other prior radiotherapy No prior pelvic radiotherapy > 30% of the bone marrow Surgery More than 28 days since prior surgery and recovered

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: capecitabine|nan|
|Drug: imatinib mesylate|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
unspecified adult solid tumor, protocol specific