fMRI of Flight of Ideas in Bipolar Disorder

Study Overview
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Brief Summary
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Bipolar disorder is a mental disease characterized by mood dysregulation and arises from manic, depressive or mixed episodes. The observations of the patient's speech and language behaviour due to flight of ideas or loss of goal probably result from an underlying disturbance in semantic networks dealing with semantic associations. The aim of our study will be to have a better comprehension of thought disorders in bipolar disorder by cognitive exploration of semantic processing.

Detailed Description
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Bipolar disorder is a mental disease characterized by mood dysregulation and arises from manic, depressive or mixed episodes. During these episodes, formal thought disorders are observed, associated to emotional perturbation, behaviour troubles and some psychotic symptoms. During mania, the type of thought disorders observed are derailment, flight of ideas, with an increase in the amount of spontaneous speech and loss of goal. These observations of the patient's speech and language behaviour probably result from an underlying disturbance in semantic networks dealing with semantic associations. These networks have been studied extensively in schizophrenia but remain unknown in bipolar disorder. In this context, the aim of our study will be to have a better comprehension of formal thought disorders in bipolar disorder by cognitive exploration of semantic activation and inhibition.

Official Title
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Functional Magnetic Resonance Imaging of Formal Thought Disorders in Bipolar Disorder

Conditions
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Bipolar Disorder

Intervention / Treatment
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* Other: Functional Magnetic Resonance Imaging


Participation Criteria
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Eligibility Criteria
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Inclusion criteria BD patients : Men or women, right-handed diagnosis of type 1 bipolar disorder, according to the DSM-IV criteria aged from 18 to 65 years-old Native French speaker Affiliated to the social security Healthy Controls (HC): Men or women, right-handed aged from 18 to 65 years-old Native French speaker Affiliated to the social security Exclusion criteria BD patients : recent alcohol and/or drug abuse or dependence significant general medical illness, including neurological disorders or head trauma sensorial impairment (visual and/or hearing) Contraindication to the use of MRI HC: first-degree-relative history of bipolar disorder, schizophrenia or schizoaffective disorder according to DSM-IV recent alcohol and/or drug abuse or dependence significant general medical illness, including neurological disorders or head trauma sensorial impairment (visual and/or hearing) Contraindication to the use of MRI

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Bipolar Disorder patients<br> | Other: Functional Magnetic Resonance Imaging<br> <br> |
| Experimental: Healthy Controls<br> | Other: Functional Magnetic Resonance Imaging<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| brain activation profiles by Functional Magnetic Resonance Imaging |  | inclusion visit |