Metabolism and Oxygen Consumption During Functional Electrical Stimulation Cycling in COPD

Study Overview
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Brief Summary
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Chronic Obstructive Pulmonary Disease (COPD) had systemic repercussion and lead to peripheral muscular dysfunction. Muscular atrophy limits aerobic capacity and is a major limitation of daily activity and quality of life. Technologies likes' neuromuscular electrical stimulation (NMES) are currently being adapted and tested to support exercise training. The investigators hypothesized that functional electrical stimulation cycling improves VO2 and aerobic capacities during exercise compared to endurance training.

Conditions
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COPD

Intervention / Treatment
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* Device: FES-cycling
* Device: Classic cycloergometer


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: COPD (Stade II, III or IV) Inform consent Exclusion Criteria: Pulmonary rehabilitation contraindication Patient with Pacemaker Patient in acute exacerbation Patient with neurologic comorbidity Anemiae

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: One single arm group<br>COPD included in a pulmonary rehabilitation program Intervention: Investigators used a bedside cycloergometer with electrical stimulation. COPD perform 2 measure of oxygen uptake during exercise for compare aerobic capacities: Functional Electrical Stimulation Cycling (FES-cycling) Classic Cycloergometer endurance training with a sham electrical stimulation | Device: FES-cycling<br>* Patients performed an endurance tests with functional electrical stimulation during 30 minutes with an oxygen uptake measure.<br>Device: Classic cycloergometer<br>* Patients performed an endurance tests on classic ergometer during 30 minutes with a sham electrical stimulation with an oxygen uptake measure.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| oxygen uptake (VO2) |  | during 30 minutes exercise | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ratio Ventilation/VO2 (Ventilation equivalent for oxygen) | Number of liters of air must be ventilated to consume 1 liter of O2 | during 30 minutes exercise | 
| Ratio Ventilation/VCO2 (Ventilation equivalent for carbon dioxide) | Number of liters of air must be ventilated to reject 1 liter of CO2 | during 30 minutes exercise | 
| cardiac output |  | during 30 minutes exercise | 
| Muscular fatigue |  | after 30 minutes exercise | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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COPD, Functional Electrical Stimulation Cycling, Pulmonary Rehabilitation