Lean Seafood Intake and Postprandial Metabolism

Study Overview
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Brief Summary
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Despite numerous studies of meal components in humans, little is still known about how different meals influence on metabolism. The purpose of this study is to a gain knowledge of how a balanced test meal with either lean seafood (example:cod) or meat as the main protein source will: affect the postprandial metabolism acutely (test-meal at beginning of the study) affect the postprandial metabolism after 4 weeks controlled intervention (test meal at end of intervention period) affect gut microbiota composition

Official Title
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Ability of a Lean Seafood Diet to Modulate Postprandial Metabolism in Human-beings - a Controlled Intervention Study With Cross-over Design

Conditions
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Hyperlipidemias, Nutritional and Metabolic Diseases, Nutrition Disorders, Metabolic Diseases, Glucose Metabolism Disorders

Intervention / Treatment
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* Dietary Supplement: Lean seafood
* Dietary Supplement: Meat, egg, milk


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 18-65 years of age Caucasian Exclusion Criteria: Smoking Diabetes Hysterectomy Abnormal bleeding last 6 months Use of medication that affects lipid and glucose metabolism Large (>10%) alteration in body-weight the last 6 months Chronic, metabolic or acute disease or major surgery within last 3 months Dietary incompatibility with calcium supplementation and/ or seafood consumption (allergy, intolerance, dislike)

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Lean seafood<br>Cross-over design, half of the subject will receive lean seafood in study period I and the other half in study period II | Dietary Supplement: Lean seafood<br> <br> Dietary Supplement: Meat, egg, milk<br> <br> |
| Active Comparator: Meat, egg, milk<br>Cross-over design, half of the subject will receive meat, egg, milk in study period I and the other half in study period II | Dietary Supplement: Lean seafood<br> <br> Dietary Supplement: Meat, egg, milk<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postprandial lipid measurement |  | Change from baseline at 4 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postprandial glucose measurement |  | Change from baseline at 4 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Seafood, Meat, Egg, Milk, Postprandial lipid metabolism, Postprandial glucose metabolism, Triglycerides, Cholesterol, Postprandial incretins, Postprandial hormones