linjc16/ctgov huggingface dataset:
Healthcare Renunciation During the Confinement Period in Connection With the COVID-19 Epidemic in Adult Emergency Departments

Study Overview
=================
Brief Summary
-----------------
Healthcare renunciation is defined as: Individuals give up care when they do not seek services and health care professionals when they experience a disorder, experience a physical or mental disorder, or when they do not access all of the prescribed care. In 2008, 16.5% of the general French population reported having renounced care. The causes mentioned of the renunciation are mainly the financial difficulties, the deadlines of appointments considered too long, the geographical remoteness. In the department of Sarthe, the rate of cessation of care is estimated at 27.6% over the period from 2014 to 2017. In the context of the COVID-19 epidemic, containment was applied in France counted from 17 March 2020. The widespread message was save lives, stay at home. The Ministry of Solidarity and Health has provided health professionals with a circular to adapt the management of patients with chronic disease, requiring elective surgical care and pregnant women. The decline in activity of general practitioners is estimated at 44% and that of other specialists at 71%. In Paris, visits to the emergency room fell by 45% for adults and 70% for children. The main risk is the deterioration of the health status of some patients with the worsening of chronic diseases, the discovery of pathologies during episodes of decompensation and the absence of management of serious acute pathologies. The study aims to assess the importance of giving up care during this period of COVID-19 and in comparison with a study conducted at the University Hospital of Angers and the hospital of Le Mans in 2017.

Official Title
-----------------
Healthcare Renunciation During the Confinement Period in Connection With the COVID-19 Epidemic in Adult Emergency Departments

Conditions
-----------------
Emergency Medicine

Intervention / Treatment
-----------------
* Other: survey


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All adults patients consulting in the emergency department and agreeing to answer the questionnaire Exclusion Criteria: Patient admitted in the emergency department in serious condition (life distress) Person unable to consent

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: survey|Each admitted patient will complete a questionnaire|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| rate of patients who gave up consulting in the emergency department |  | 1 day |
Psychosocial Aspects of Multiple Endocrine Neoplasia (MEN) Syndromes

Study Overview
=================
Brief Summary
-----------------
The specific aims of the study include: Profile the demographic, health-related, psychosocial and behavioral characteristics of adults with MEN1 or MEN2. Evaluate MEN-specific distress as well as adherence to surveillance regimens among adults with MEN1 or MEN2, and identify associated with those outcomes.

Detailed Description
-----------------
The proposed cross-sectional study is intended to obtain information regarding current surveillance behaviors and other psychosocial outcomes among persons affected by the multiple endocrine neoplasia (MEN) 1 or MEN2, which are inherited conditions. Study participants will include patients who have been seen previously at MDACC for evaluation of MEN1 or MEN2. Because this is the first time investigators are contacting these patients to invite them to participate in psychosocial research, the proposed study also will help determine the feasibility of conducting similar studies in the future. Investigators anticipate that data gathered from this study will enhance existing knowledge about the psychological and behavioral aspects of the MEN syndromes, and will inform future research efforts directed toward this understudied population.

Official Title
-----------------
Psychosocial Aspects of Multiple Endocrine Neoplasia (MEN) Syndromes

Conditions
-----------------
Multiple Endocrine Neoplasia

Intervention / Treatment
-----------------
* Behavioral: Questionnaire


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adults age 18 years or older, with a clinical or genetic diagnosis of MEN1 or MEN2 Spouse, Significant Other, or Family Member who is at least 18 years of age and who is related to an individual who is a patient at MDACC and who has been diagnosed with MEN1. Ability to read and write English Exclusion Criteria: 1) Inability to be contacted via mail (i.e., no contact information on record, incorrect address)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Multiple Endocrine Neoplasia (MEN)<br>Patients with multiple endocrine neoplasia (MEN). | Behavioral: Questionnaire<br>* Mailed packets including cover letter describing purpose of study, study questionnaire, and return envelope.<br>* Other names: Survey;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Profile the demographic, health-related, psychosocial and behavioral characteristics of adults with MEN1 or MEN2. |  | 3 Years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Multiple Endocrine Neoplasia, Questionnaire, Psychosocial, Surveillance Behaviors, MEN Syndromes
The Distribution of Body Constitutions Among Hong Kong Elderly Population: A Cross-sectional Study

Study Overview
=================
Brief Summary
-----------------
Hong Kong, similar as other developed economic entities, has been faced big challenges from increasing medical burden and aged population. Based on the updated estimates of domestic health expenditure by Food and Health Bureau HKSAR, the total health expenditure amounted to HK$112,144 million in 2012/13 with increasing approximate 4 times than 1992/93. According to the data from Census and Statistics Department, in 2010, there was still 13% population aged above 65 years, while in 2039, this percentage will be elevated to 28% (http://www.censtatd.gov.hk/hkstat/sub/so20.jsp). In other words, every three individuals will contain a person aged above 65 years in the future 30 years. Therefore, how to release the medical burden resulted from aged tendency of population is the critical question in optimizing the treatment expenses. Our aims in the cross-sectional study are to 1) estimate the number and percentage of nine body constitutions among population aged 65 and over in Hong Kong 2) identify the associations between nine body constitutions and other predetermined factors such as gender, weight, diet, body mass index (BMI), blood pressure, quality of life scale scores, et al.

Official Title
-----------------
The Distribution of Body Constitutions Among Hong Kong Elderly Population: A Cross-sectional Study

Conditions
-----------------
Nine Body Constitutions

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: aged 65 and over capable of consenting and have agreed to participate, ambulatory, and not receiving treatment modalities, which, if omitted, may result in immediate life threatening risk such as chemotherapy or radiotherapy for cancer, or dialysis for renal failure Exclusion Criteria: neurological disorders such as dementia

Ages Eligible for Study
-----------------
Minimum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Distribution of nine body constitutions assessed by the TCM Body Constitution Questionnaire (For Elderly People) (Cantonese version) | The primary outcome will be the distribution of nine body constitutions in Hong Kong aged 65 and over population. | through study completion, an average of 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between body constitution distribution and other predetermined factors | Secondary outcomes will be the correlation between body constitution distribution and other predetermined factors such as gender, age, weight, dietary habit, education and quality of life scores (SF-36 Hong Kong questionnaire), et al. | through study completion, an average of 1 year |
Monotherapy Versus Placebo Over 14 or 17 Days in Healthy and Hepatitis C Infected Adults

Study Overview
=================
Brief Summary
-----------------
This study represents the first administration of GSK625433 in humans. The study is designed to evaluate initial safety and tolerability in healthy adults as well as anti-viral activity in Hepatitis C(HVC) infected adults. The way the human body processes GSK625433 will also be investigated.

Official Title
-----------------
A Double-Blind, Parallel, Randomized, Placebo-Controlled, Single and Repeat Dose Escalation Study to Investigate the Safety, Tolerability and Pharmacokinetics of GSK625433 in Healthy Subjects and in Subjects Who Are Chronically Infected With Hepatitis C.

Conditions
-----------------
Hepatitis C, Chronic, Hepatitis C

Intervention / Treatment
-----------------
* Drug: GSK625433/placebo


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: Healthy males & females Part 1 ages 18-60 Part 2 ages 18-50 & 65-80 Within normal weight range given your height Negative urine drug and alcohol test Willing to follow all study procedures Exclusion criteria: Any significant abnormal lab, ECG, medical or physical exam finding during screening Allergy to the study drug Excessive alcohol intake Positive HIV or hepatitis B or C result Use of prescription or non-prescription drugs within one week of study start except for birth control Blood pressure meds & Tylenol Pregnant or lactating women

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: GSK625433/placebo|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Safety parameters: adverse events; telemetry; clinical laboratory values, vital signs, and ECGs. Plasma levels of GSK625433. Change in HCV viral load. Taken throughout the study |  | 17 Days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Plasma levels of GSK625433. Metabolic analysis of CYP substrates to estimate enzyme activity. Resistance analysis for subjects with HCV infection. Taken throughout the study |  | 17 Days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
GSK625433,, Hepatitis C,, metabolic probe,, food-effect,, HCV,, FTIH, polymerase,
The Study of the Nonunion of Long Tubular Bone

Study Overview
=================
Brief Summary
-----------------
The purpose of the study to supplied the diagnostic and treatment criteria of the nonunion of the long tubular bone after treatment of Intramedallery nailing

Official Title
-----------------
The Prospective、Randomized、Comparative Clinical Study About the Two Operation Methods Between Anti-rotational Plate Group and Exchanged Intramedullary Nailgroup to Treat the Nonunion of Long Tubular Bone After Intramedullary Nail Fixation

Conditions
-----------------
Diaphyses

Intervention / Treatment
-----------------
* Device: Anti-rotational plate
* Device: Exchanged Intramedullary nailing


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: The patient who had the nonunion of long tubular bone The patient who was the age of 14   65 years old. The patient who complete the follow-up conditions. The patient who has independent behavior ability. The patient who volunteered for signed informed consent Exclusion Criteria: Infectious nonunion of the long turubar bone Pathological fracture. The immune system disease. Cancer

Ages Eligible for Study
-----------------
Minimum Age: 14 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: The Anti-rotational plate group<br>The method was used to control the rotational unstabilization at the fracture site | Device: Anti-rotational plate<br> <br> Device: Exchanged Intramedullary nailing<br> <br> |
| Placebo Comparator: Exchanged Intramedullary nailing group<br>the method Provided the axial and rotational stability | Device: Exchanged Intramedullary nailing<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The healing rate |  | 9 months |
PPAR - Combination With Metformin

Study Overview
=================
Brief Summary
-----------------
A Phase 3, Randomized, Double-blind, Placebo Controlled, Multicenter Trial to Evaluate the Safety and Efficacy of BMS-298585 in Combination with Metformin Therapy in Subjects with Type 2 Diabetes Who Have Inadequate Glycemic Control on Metformin Therapy Alone

Official Title
-----------------
A Phase 3, Randomized, Double-blind, Placebo Controlled, Multicenter Trial to Evaluate the Safety and Efficacy of BMS-298585 in Combination With Metformin Therapy in Subjects With Type 2 Diabetes Who Have Inadequate Glycemic Control on Metformin Therapy Alone

Conditions
-----------------
Diabetes Mellitus

Intervention / Treatment
-----------------
* Drug: Muraglitazar


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Type 2 Diabetes HbA1c > - 7.0% and < - 10.0 % Mean serum triglyceride < - 600 mg/dL Body mass index < - 41 kg/m2 Fasting c-peptide > - 1.0 ng/mL Exclusion Criteria: History of myocardial infarction (MI) coronary angioplasty or bypass graft(s) valvular disease or repair unstable angina pectoris transient ischemic attack (TIA), cerebrovascular attack, or cerebrovascular accident (CVA) within 6 months Congestive heart failure NYHA Class III and IV Uncontrolled hypertension History of renal disease, peripheral vascular disease (PVD), pulmonary disease, gastrointestinal disease, active liver disease or endocrine disease

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Muraglitazar|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| compare change from baseline in HbA1c after 24 weeks of treatment with muraglitazar + metformin vs placebo + metformin |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change in FPG from basline to W24, proportion of subjects receiving therapeutic response at W24, percent change of fasting lipid levels from baseline to W11/12, change in hs-CRP from baseline to W24 |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Metabolics Diabetes New Onset
EEG Objectification in Neuropsychiatry

Study Overview
=================
Brief Summary
-----------------
The main objective of the study is to evaluate the use of EEG in the management and follow-up of neuropsychiatric disorders. Secondary objectives are therefore better understanding of the pathological activations in neural network during neuropsychiatric disorders, their clinical evolution and response to therapies.

Detailed Description
-----------------
Patients are having EEG recordings as a routine part of their clinical evaluation and diagnosis. EEG recording is harmless, has no side effects, any radiation or any mechanical or electrical influence. It is of short duration and may be done in the EEG institute or the patient's room.

Official Title
-----------------
EEG Objectification in Neuropsychiatry

Conditions
-----------------
Personality Disorder, Depression, Neurodegeneration, Alzheimer's Disease, Epilepsy

Intervention / Treatment
-----------------
* Device: EEG recording


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: diagnosis of the investigated neuropsychiatric disease Exclusion Criteria: Other co-existing neuropsychiatric conditions Refusal to participate in the study

Ages Eligible for Study
-----------------
Minimum Age: 15 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: study group<br>EEG recording | Device: EEG recording<br>* EEG recording<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| percentage of fitting (0-100%) of EEG pattern to a previously identified electrophysiological key | The study will decode an EEG-based key (or electrophysiological pattern) for specific effect (such as the use of anti-epileptic agent or a certain condition) by comparing EEG before and after the use of this agent. For each patient the statistical fitting of the recorded EEG to the key will be evaluated by percentage (0-100%), describing fitting of the individual patient's EEG to the identified key. | 1 year |
Migration Pattern of C-stem AMT Versus Exeter in Total Hip Arthroplasty

Study Overview
=================
Brief Summary
-----------------
Hypothesis: Migration of C-Stem AMT is equal to the well documented Exeter prosthesis In Norway it is annually performed approximately 600 primary and 100 revisions THA. Osteolysis around the prosthesis is one of the major difficulties while performing revision surgery. C-stem is a triple tapered cemented prosthesis designed to increase the stress and strain of proximal femur and thereby decreasing osteolysis. We are planning til include 70 patients and randomize to C-stem AMT or Exeter prosthesis. Both prosthesis will be combined with previously non documented Marathon acetabular prosthesis. The result will be followed clinically and with RSA and DXA. Soft endpoint after 2 years

Official Title
-----------------
Migration Pattern of C-stem AMT Versus Exeter in Total Hip Arthroplasty

Conditions
-----------------
Coxarthrosis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: coxarthrosis Exclusion Criteria: age over 80 major medial condition such as renal failure, chronic obstructive lung disease heart failure etc

Ages Eligible for Study
-----------------
Minimum Age: 30 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br> | |
| 2<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Migration of femur- and acetabular prosthesis measured by RSA |  | 2008-2012 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Periprosthetic osteolysis of proximal femur |  | 2008-2012 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
coxarthrosis, hip, RSA, DXA, C-stem AMT, Marathon