Inspiratory Muscle Training in Pulmonary Hypertension

Study Overview
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Brief Summary
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The aim of this study is to investigate the effective of inspiratory muscle training on respiratory function, exercise capacity, physical activity and quality of life.

Detailed Description
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Pulmonary hypertension (PH) is a condition which is seen with hemodynamic differences, pulmonary vascular resistance and right heart failure. Patients with pulmonary hypertension have, dyspnea, physical inactivity, reduced condition and respiratory muscle dysfunction. Aerobic exercise programs in patients with pulmonary hypertension are reported to result in improved exercise capacity and endurance of the patients, improvement in WHO functional class and quality of life, increased peak workload and increased peripheral muscle function. In recent years, few studies have investigated the efficacy of inspiratory muscle training in patients with PH.The aim of this study is to investigate the effective of inspiratory muscle training on respiratory function, exercise capacity, physical activity and quality of life.

Official Title
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The Effects of Inspiratory Muscle Training on Exercise Capacity, Physical Activity and Quality of Life in Pulmonary Hypertension

Conditions
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Pulmonary Hypertension

Intervention / Treatment
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* Other: inspiratory muscle training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosis of Pulmonary Hypertension, NYHA functional class I-IV MIP pressure <80 cm h2O Exclusion Criteria: COPD Conditions which can limit the assessments Insufficient cooperation

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Patients will randomize into two groups as Group A: inspiratory muscle training, and Group B (control group)
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Inspiratory muscle training group<br>Patients will continue 8 weeks, 5 days, 2 times 15 minutes training program with %30 MIP at home. | Other: inspiratory muscle training<br>* The treatment group received IMT. Patients were trained using an inspiratory threshold-loading device<br>|
| No Intervention: control group<br>Patients will continue 8 weeks, 5 days, 2 times 15 minutes training program with 9 cmH2O pressure at home. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| mouth pressures | MIP and MEP | 10 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| International Physical Activity Questionnaire-Short Form | Physical activity | 10 minutes | 
| Minnesota Living with Heart Failure Questionnaire | quality of life | 15 minutes | 
| Activity monitoring (Sense wear® Armband) | Metabolic holter | 3 days | 
| 6 minute walking test | functional capacity | 15 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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pulmonary hypertension, inspiratory muscle training, functional capacity, physical activity