Progressive Resistance Exercise in Rheumatoid Arthritis

Study Overview
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Brief Summary
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A randomized controlled trial with rheumatoid arthritis patients will be realized. Patients will be randomized into two groups. Experimental group will do a 12 weeks training of progressive resistance exercise for global muscles and remain with the clinical treatment and the control only remain with the clinical treatment. Patients will be evaluated at baseline, after 6, 12 and 24 weeks.

Official Title
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Progressive Resistance Exercise in Rheumatoid Arthritis Patients: a Randomized Controlled Trial

Conditions
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Rheumatoid Arthritis

Intervention / Treatment
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* Other: Control group
* Other: Experimental group


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Rheumatoid arthritis according to American College of Rheumatology 2010 Both genders Age between 18 and 65 years Functional class I, II and III Stable medication within the three months preceding the study Haven't done any kind of regular exercise (two or more times per Week) for at least three months before study start Have agreed to participate in the study and signed an informed consent form. Exclusion Criteria: Participating in another type of study Have difficulty understanding the evaluation tools with fibromyalgia Joint deformities that make impossible do the exercises Other musculoskeletal diseases Other diseases that contraindicate exercises.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Control group<br>Patient remain with their usual clinical treatment. | Other: Control group<br> <br> * Other names: Clinical tretament;|
| Experimental: Experimental group<br>Patients in experimental group participated in a 12-week progressive resistance training using a maximum repetition exercise in which patients performed 1 Maximum Repetition with the maximum bearable weight. Once the 1 Maximum Repetitionwas determined, training was divided into the following regimen: 2 series of 8 repetitions, the first with 50% and the second with 70% of 1 Maximum Repetition. The exercises were knee extension and flexion and hip abduction and adduction, elbow extension and flexion, wrist extension and flexion and shoulder abduction and adduction and spine extension and flexion all performed in machines. The 1 Maximum Repetition load was reevaluated every 6 weeks. Patient remain with their usual clinical treatment. | Other: Control group<br> <br> * Other names: Clinical tretament;Other: Experimental group<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in pain - Visual analogue scale |  | baseline, 6, 12 and 24 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in function capacity - Health Assessment questionaire |  | Baseline, after 6, 12 and 24 weeks | 
| Change in quality of life - Short form 36 |  | baseline, after 6, 12 and 24 weeks | 
| Change in strength - 1 maximum repetition |  | baseline, after 6, 12 and 24 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Rheumatoid arthritis, Progressive resistance exercise, Pain, Functional capacity, Quality of life, Muscle strength