linjc16/ctgov huggingface dataset:
Koning Breast Computed Tomography Guided Biopsy

Study Overview
=================
Brief Summary
-----------------
The primary aim of this study is to show that the accuracy of Koning Breast CT-guided biopsy is at least equivalent to that of stereotactic-guided biopsy.

Official Title
-----------------
Koning Breast CT-guided Biopsy Phase I Trial

Conditions
-----------------
Breast Cancer

Intervention / Treatment
-----------------
* Device: Koning Breast CT-guided Biopsy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Female at least 35 years of age of any ethnicity Lesion seen on mammography Diagnostic report read as BI-RADS 4 or 5 Will undergo biopsy no later than four weeks from date of mammogram Is able to undergo informed consent Exclusion Criteria: Pregnancy Lactation Subjects with breast implants Subjects with physical limitations that may prohibit resting prone on the exam table, such as, but not limited to: frozen shoulder, recent heart surgery, pacemaker. Subjects who are unable to tolerate study constraints. Subjects who have received radiation treatments to the thorax for malignant and nonmalignant conditions, such as (but not limited to) Treatment for enlarged thymus gland as an infant Irradiation for benign breast conditions, including breast inflammation after giving birth Treatment for Hodgkins disease Subjects who have participated in a prior breast clinical trial that gave additional radiation dose, such as an additional mammogram. Subjects who have received large numbers of diagnostic x-ray examinations for monitoring of disease such as (but not limited to) Tuberculosis Severe scoliosis

Ages Eligible for Study
-----------------
Minimum Age: 35 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Koning Breast CT - guided Biopsy<br> | Device: Koning Breast CT-guided Biopsy<br>* The breast will be positioned and stabilized in the grid/compression device. Four KBCT scans will be taken to guide the vacuum-assisted biopsy procedure.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The accuracy of Koning breast CT-guided biopsy | The goal of this study is to evaluate the concordance of Koning Breast CT-guided Biopsy (KBCT-GBx) results to diagnostic work-up imaging (at least mammographic) and KBCT imaging and to verify that the localization and guidance accuracy of KBCT-GBx is at least equivalent to stereotactic-guided biopsy to validate the localization and guidance accuracy of KBCT-GBx. | about 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Breast CT, Biopsy
Tubeless Versus Standard Upper Pole Percutaneous Nephrolithotomy

Study Overview
=================
Brief Summary
-----------------
Comparison of complications between standard upper pole percutaneous nephrolithotomy (PCNL) with nephrostomy placement and double J stent and PCNL with double J placement only without nephrostomy.

Detailed Description
-----------------
Measurement of complications in and comparison between two groups of patients undergoing upper pole PCNL. First group consists of patients left with nephrostomy and double J stent and the second group includes patients left with double J stent only without nephrostomy.

Official Title
-----------------
Comparison of Complications Between Patients Undergoing Standard Percutaneous Nephrolithotomy With Nephrostomy Tube Placement and Tubeless Percutaneous Nephrolithotomy With Double J Stent Only Placement

Conditions
-----------------
Pleural Effusion

Intervention / Treatment
-----------------
* Device: Double J stent without nephrostomy
* Device: nephrostomy tube and double J stent


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients undergoing upper pole percutaneous nephrolithotomy older than 18 years of age and willing to participate Exclusion Criteria: Patients younger than 18 years of age Patients unwilling to participate in the study Patients that nephrostomy tube placement was a prerequisite at the end of the procedure

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Nephrostomy tube + double J stent<br>Standard therapy group with nephrostomy tube and double J stent left at the end of the PCNL | Device: Double J stent without nephrostomy<br>* Double J stent only left at the end of the procedure without placement of a nephrostomy tube<br>Device: nephrostomy tube and double J stent<br>* Double J stent and nephrostomy tube left at end of procedure<br>|
| Experimental: Double J stent without nephrostomy<br>Double J stent only left at the end of the procedure | Device: Double J stent without nephrostomy<br>* Double J stent only left at the end of the procedure without placement of a nephrostomy tube<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of Participants with pleural effusion | Assessment and comparison of pleural effusion incidence between patients in both groups | 30 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Percutaneous Nephrolithotomy (PCNL), Nephrostomy, Double J stent, PleuraL Effusion
Clinical Observation of Technologic Application of No-touch Fluid-air Exchange in Surgery of Idiopathic Macula Hole

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to observe the technologic application of no-touch fluid-air exchange in Surgery of Idiopathic Macula Hole.

Official Title
-----------------
The Eye Hospital of Tianjin Medical University

Conditions
-----------------
Idiopathic Macula Hole

Intervention / Treatment
-----------------
* Procedure: no-touch fluid-air exchange
* Procedure: vitrectomy metrectomy and internal membrane peeling and gas tamponed


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All patients were diagnosed as having an idiopathic macular hole(IMH) by Optical Coherence Tomography(OCT). Exclusion Criteria: Myopia of >6 diopters Ocular trauma and other systematic or ocular issues associated with IMHs，such as the other macula disease, for example the degeneration of macula.

Ages Eligible for Study
-----------------
Minimum Age: 50 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: no-touch fluid-air exchange group<br>All patients in no-touch fluid-air exchange group will have a surgery of vitrectomy metrectomy and internal membrane peeling and gas tamponed.In this surgery ,investigator will not touch the macular area,especially the area of the macular hole and investigator will not have the fluid-air exchange of the macular area. | Procedure: no-touch fluid-air exchange<br> <br> * Other names: vitrectomy metrectomy and internal membrane peeling and gas tamponed;Procedure: vitrectomy metrectomy and internal membrane peeling and gas tamponed<br> <br> |
| Experimental: the tradional group<br>All patients in no-touch fluid-air exchange group will have a surgery of vitrectomy metrectomy and internal membrane peeling and gas tamponed.In this surgery ,investigator will touch the macular area and investigator will have the fluid-air exchange. | Procedure: vitrectomy metrectomy and internal membrane peeling and gas tamponed<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the closure rate of Macular hole | the closure rate of macular hole through OCT | one month | 
| the closure rate of Macular hole | the closure rate of Macular hole | three month | 
| the closure rate of Macular hole | the closure rate of Macular hole | six month |
Chemoreflex Gain on Exercise

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to assess chemoreflex gain on exercise.

Detailed Description
-----------------
Normally breathing is controlled by a reflex that responds to the levels of carbon dioxide (CO2) in the blood. The change in breathing that results from a change in the blood's CO2 concentration is called the chemoreflex. In heart failure, a condition where the heart muscle is damaged and can not pump as well, this reflex is exaggerated. The result of this can be breathing conditions characterised by patients hyperventilating at times and at other times taking very shallow breaths or even stopping altogether. In the past the only way of measuring this chemoreflex was to get patients to breathe into a large container and to rebreathe their exhaled air and allow the CO2 to rise over time, whilst keeping the oxygen constant. The proportion by which the ventilation increases with increasing carbon dioxide is the chemoreflex gain. Unfortunately, because this test takes a long time to conduct, requires specialist knowledge and equipment it has not been possible to measure this reflex on exercise.

Official Title
-----------------
Chemoreflex Gain on Exercise

Conditions
-----------------
Exertional Periodic Breathing

Intervention / Treatment
-----------------
* Other: carbon dioxide


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Volunteers: Males aged 18-80 years who are able to perform both running and cycling and can follow simple visual instructions. Heart Failure Subjects: Males aged 18-80 with a clinical diagnosis of heart failure who are able to perform both running and cycling and can follow simple visual instructions. Exclusion Criteria: Chest pain of any cause within 4-6 days, Pulmonary oedema, Uncontrolled hypertension (systolic blood pressure > 220 mm Hg, diastolic >120 mm Hg), Severe aortic stenosis, Severe hypertrophic obstructive cardiomyopathy, Untreated life threatening arrhythmia, Dissecting aneurysm, Recent surgery (within 4-6 weeks), COPD.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: carbon dioxide|sinusoidal carbon dioxide delivery|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| chemoreflex gain on exercise |  | every minute | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Reproducibility of chemoreflex gain on exercise |  | every minute | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
chemosensitivity
Antiproteinuric Efficacy of Losartan Potassium in Patients With Non-Diabetic Proteinuric Renal Diseases (0954-213)

Study Overview
=================
Brief Summary
-----------------
Antiproteinuric Efficacy of Losartan Potassium in Patients with Non-Diabetic Proteinuric Renal Diseases.

Official Title
-----------------
A Randomized, Parallel, Double Blind Study of Losartan Versus Amlodipine in Patients With Mild to Moderate Hypertension and Chronic Nondiabetic Proteinuric Nephropathy: Evaluation of the Effect on Proteinuria and on the Plasmatic Levels of Growth Factors (TGFß and VEGF)

Conditions
-----------------
Renal Disorder

Intervention / Treatment
-----------------
* Drug: MK0954, losartan potassium/Duration of Treatment: 20 weeks
* Drug: Comparator: amlodipine / Duration of Treatment: 20 weeks


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Males or females at least 18 years of age with non-diabetic proteinuric renal diseases

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: MK0954, losartan potassium/Duration of Treatment: 20 weeks|nan|
|Drug: Comparator: amlodipine / Duration of Treatment: 20 weeks|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 24h proteinuria |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in the plasma and urinary levels of TGF-beta |  |  |
A Wireless Lingual Feedback Device to Reduce Overpressures in Seated Posture: A Feasibility Study

Study Overview
=================
Brief Summary
-----------------
This study evaluates the feasibility of a biofeedback system aimed at reducing overpressures during seated posture. The system consists of (1) a pressure sensors map, (2) a laptop that couples sensors with actuators, (3) a Tongue Display Unit (TDU) consisting of a wireless circuit embedded in a dental retainer with a matrix of electrodes. The principle of this biofeedback system consists in (1) detecting overpressures in people who are seated over long periods of time, (2) estimating a postural change that could reduce these overpressures and (3) communicating this change through directional information transmitted by the TDU. It is hypothesized that overpressures are diminished after biofeedback.

Official Title
-----------------
A Wireless Lingual Feedback Device to Reduce Overpressures in Seated Posture: A Feasibility Study

Conditions
-----------------
Postural Behaviour, Overpressures Reductions

Intervention / Treatment
-----------------
* Device: recordings with device equipped
* Device: Control


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: young healthy subjects Exclusion Criteria: motor or sensory disabilities

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Feedback<br>Subjects of this group are equipped with the biofeedback system | Device: recordings with device equipped<br> <br> |
| Control<br>Subjects of this group are not equipped with the biofeedback system | Device: Control<br>* Recording without device equipped<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ability to reach a target posture |  | 10 seconds | 
| Decrease of the overpressures at the seat/body interface |  | 10 seconds | 
| Decrease of overpressures bigger for higher pressures |  | 10 seconds |
Changes of the Neuronal Activity in the Subthalamic Nucleus Under Remifentanil Sedation During Stereotactic Electrode Implantation

Study Overview
=================
Brief Summary
-----------------
Deep brain stimulation is commonly used for the treatment of movement disorders. Electrode positioning is usually performed under local anesthesia in fully awake patients. The procedure is uncomfortable to the patients who has to remain motionless during the whole surgery. Previous reports of electrode positioning under general anesthesia was found to be less accurate. This result was probably due to the effect of the anesthetics on the electrical activity of the basal ganglia. The purpose of this study is to detect possible changes in the electrical activity of the basal ganglia related to remifentanil sedation. electrical activity of single neurons will be recorded before, during and after sedation.

Conditions
-----------------
Movement Disorders, Effect of Remifentanil

Intervention / Treatment
-----------------
* Drug: Remifentanil


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with movement disorder, who are candidates for implantation of deep brain stimulation electrode. Exclusion Criteria: Suspected difficult intubation history of sleep apnea known allergy for remifentanil
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: A<br>The patients get a period of sedation with remifentanil, before, during and after which, the changes in the electrical activity of the Basal Ganglia is recorded. | Drug: Remifentanil<br>* After the mapping electrode is in situ, recording of baseline electrical activity is done for two-three minutes and an infusion of Remifentanil, 0.1 microgram per kilogram per minute is started. This procedure continues for a few minutes until the patient is sedated and then the infusion is stopped and the patient allowed to recover. The recordings continue during the whole procedure.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Electrical activity in the basal ganglia |  | During the experiment | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Deep Brain Stimulation, Movement Disorders, Remifentanil, Sedation, Basal Ganglia electrical activity
Falls Prevention in Osteoporosis

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine wether a falls prevention program can reduce fall incidence in people with osteoporosis.

Detailed Description
-----------------
Falling is a major health problem in the elderly causing physical and psychosocial problems. People with osteoporosis are at higher risk for fractures due to falling, because of decreased bone strength. The 'Nijmegen Falls Prevention Program (NFPP) (Weerdesteyn et al, 2006) has been shown to reduce fall incidence rates by 46% in healthy community-dwelling elderly. This program was adapted in order to meet the specific demands and constraints of people with osteoporosis. The contents of the program are an obstacle course, walking exercises, the practice of fall techniques, adjustment of gait abnormalities, weight bearing exercises and educational sessions. The effectiveness of the program will be evaluated in a randomized clinical trial. Primary outcome measure is fall incidence. Additionally, laboratory assessments of gait and obstacle avoidance will be conducted in conjunction with questionnaires about balance confidence and activity level.

Official Title
-----------------
Falls Prevention for People With Increased Risk of Fractures as a Result of Osteoporosis: a Randomized Controlled Study on the Effects of a Modified Program

Conditions
-----------------
Osteoporosis

Intervention / Treatment
-----------------
* Procedure: Falls Prevention Program


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: osteoporosis (DXA T-score < -2.5 in hip and/or vertebrae) able to walk at least 15 minutes without an helping device 65 years or older community dwelling at least one fall in the prior year Exclusion Criteria: severe cardiac, pulmonary or musculoskeletal disorders pathologies associated with increased fall risks (i.e. stroke or Parkinson's disease) use of psychotropic drugs

Ages Eligible for Study
-----------------
Minimum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Falls Prevention Program|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fall incidence, which is measured by monthly fall registration cards |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Obstacle avoidance performance |  |  | 
| Fear of falling (ABC) |  |  | 
| Activity level (LAPAQ) |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
osteoporosis, falls, prevention, elderly, exercise, incidence, obstacle avoidance