Suicide Prevention Intervention for Schizophrenia-Spectrum Disorders

Study Overview
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Brief Summary
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The current project is a pilot randomized controlled trial to test the Coping Long-term with Active Suicide Program for schizophrenia-spectrum disorders (CLASP-S) for patients following a psychiatric hospitalization. Participants will be assigned to enhanced treatment as usual (ETAU) alone vs CLASP-S plus ETAU. Participants complete assessments at baseline during their psychiatric hospitalization and at 3 months (mid-treatment) and 6 months (post-treatment) following discharge. The primary aim is to assess the feasibility and acceptability of CLASP-S. The secondary aim is to estimate the effects of CLASP-S on reducing suicidal thoughts and behaviors relative to ETAU.

Official Title
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Post-Hospital Suicide Prevention Intervention for Patients With Schizophrenia-Spectrum Disorders

Conditions
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Schizophrenia, Suicide

Intervention / Treatment
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* Behavioral: Enhanced Treatment as Usual
* Behavioral: Coping Long-term with Active Suicide Program for Schizophrenia


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: suicidal thoughts or behaviors prior to hospital admission diagnosis of a schizophrenia-spectrum disorder receiving pharmacotherapy 18 years or older speaks/reads English Exclusion Criteria: psychosis due to substance use or medical condition lack of phone access discharge to long-term facility

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Enhanced Treatment as Usual<br>Participants assigned to Enhanced Treatment as Usual (ETAU) alone will receive unrestricted routine care in the community. Assessment feedback reports will be sent to participants' community providers at baseline, 3 months, and 6 months for care coordination. | Behavioral: Enhanced Treatment as Usual<br>* Routine community care plus assessment feedback reports to clinicians.<br>|
| Experimental: Coping Long-term with Active Suicide Program for Schizophrenia<br>Coping Long-term with Active Suicide Program for Schizophrenia-Spectrum Disorders (CLASP-S) includes 3 individual sessions, 1 family meeting, and 11 phone sessions with the participant and their significant other over 6 months post-hospital discharge. | Behavioral: Enhanced Treatment as Usual<br>* Routine community care plus assessment feedback reports to clinicians.<br>Behavioral: Coping Long-term with Active Suicide Program for Schizophrenia<br>* Adjunctive psychosocial intervention for suicide prevention involving in person, family, and phone sessions.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Client Satisfaction Questionnaire | The Client Satisfaction Questionnaire is a self-report measure of patient satisfaction with treatment. The total score (sum of items) will be used and ranges from 8 to 32 with increased scores indicating greater satisfaction with treatment. | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Columbia Suicide Severity Rating Scale | The Columbia Suicide Severity Rating Scale is an interviewer-rated measure of suicidal thoughts and behaviors. The total score (sum of items) will be used and ranges from 2 to 25 with higher scores indicating higher suicidal thoughts and behaviors. | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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psychiatric hospitalization, suicide prevention, psychosis, psychosocial intervention