Factors for Predicting Severe Asthma Exacerbators in Adult Asthmatics: A Real Word- Effectiveness Study

Study Overview
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Brief Summary
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This study is a single-center, retrospective, cross-sectional study. It plan to investigate the predictors for asthma exacerbation in long term follow up real world management with analyzing big data of electronic medical records (EMR).

Detailed Description
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The long-term goals of asthma treatment are to achieve well control of symptoms and to minimize the future risk of asthma exacerbations (AEs). Asthma is a heterogeneous disease with various responses to treatment and clinical outcomes. AEs are a prominent feature of severe asthmatics; however, frequent AEs have also been reported in mild asthmatics. This is a prospectively designed observational study to identify predictors for patients with frequent AEs among adult asthmatics by analyzing medical big data of electronic medical records (EMR), which will provide an insight in the long-term management of adult asthmatics in real-world practice.

Official Title
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Factors for Predicting Severe Asthma Exacerbators in Adult Asthmatics: A Real Word- Effectiveness Study

Conditions
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Asthma

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Aged ≥17 years Patients having bronchial asthma with J45-J46 code of International classification of Diseases (10th edition on EMR) Asthmatics who had been treated by allergy or respiratory specialists Exclusion Criteria: Patients who has less than one year for asthma treatment

Ages Eligible for Study
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Minimum Age: 17 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Identifying prognostic factors for risk of severe asthma exacerbation | Identifying prognostic factors for risk of severe asthma exacerbation | During the initial 2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluating total IgE (KU/L) to predict severe asthma exacerbation | Evaluating total IgE (KU/L) to predict severe asthma exacerbation | During 10 years of treatment | 
| Evaluating peripheral eosiniphil, neutrophil, basophil and lymphocyte counts to predict severe asthma exacerbation | Unit of peripheral eosiniphil, neutrophil, basophil and lymphocyte counts: ×10³/uL | During 10 years of treatment | 
| Evaluating ECP (ug/L) to predict severe asthma exacerbation | Evaluating ECP (ug/L) to predict severe asthma exacerbation | During 10 years of treatment | 
| Evaluating sputum eosinophils (%) to predict severe asthma exacerbation | Evaluating sputum eosinophils (%) to predict severe asthma exacerbation | During 10 years of treatment | 
| Evaluating FEV1 (%) and FEV1/FVC (%) to predict severe asthma exacerbation | Evaluating FEV1 (%) and FEV1/FVC (%) to predict severe asthma exacerbation | During 10 years of treatment | 
| Comparing clinical characteristics according to the frequency of severe asthma exacerbation | Comparing clinical characteristics according to the frequency of severe asthma exacerbation | During the initial 2 years | 
| Sensitivity and specificity of predictors | Sensitivity and specificity of predictors | during the initial 2 years and the following 3-10 years of treatment |