A Single-center Study on the Effect of Systemic/Selective Lymph Node Dissection on the Prognosis of Ground Glass Nodules Smaller Than 3cm and With Components With Consolidation/Tumor Ratio Between 0.5-1

Study Overview
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Brief Summary
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A single-center study on the effect of systemic/selective lymph node dissection on the prognosis of ground glass nodules smaller than 3cm and with components with consolidation/tumor ratio between 0.5-1

Detailed Description
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A single-center study on the effect of systemic/selective lymph node dissection on the prognosis of ground glass nodules smaller than 3cm and with components with consolidation/tumor ratio between 0.5-1

Official Title
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A Single-center Study on the Effect of Systemic/Selective Lymph Node Dissection on the Prognosis of Ground Glass Nodules Smaller Than 3cm and With Components With Consolidation/Tumor Ratio Between 0.5-1

Conditions
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Progression, Postoperative Recovery

Intervention / Treatment
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* Other: selective lymph node dissection
* Other: Systemic Lymph Node Dissection


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients enrolled in the study must meet all of the following conditions: 1.Aged between 25 and 75 years; 2. GGO is diagnosed by thin-section lung CT (thickness <1.5mm) within one month before surgery; 3. The maximum diameter of the GGO is smaller than 3cm; 4. The solid component in GGO between 50%-100%; 5. Preoperative examination showed that the patient could tolerate lobectomy; 6. The patient is able to understand and comply with the study and has provided written informed consent. Exclusion Criteria: Patients meeting any of the following criteria are not eligible for this trial: 1. Patients with a history of lung surgery; 2. Postoperative pathology showed non-primary lung cancer; 3. The scope of surgical resection is larger than one lung lobe; 4. Patients with a history of other tumors; 5. Patients with severe complications (coronary heart disease, valvular heart disease, end-stage renal disease, severe liver cirrhosis); 6. Unable to cooperate with the researchers because of dementia or cognitive decline 7. Other situations that are not in conformity with the standards and requirements of this trial.

Ages Eligible for Study
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Minimum Age: 25 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: systemic or selective lymph node dissection group
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: systemic lymph node dissection group<br>systemic lymph node dissection group | Other: Systemic Lymph Node Dissection<br>* Systemic Lymph Node Dissection<br>|
| Experimental: selective lymph node dissection<br>selective lymph node dissection | Other: selective lymph node dissection<br>* selective lymph node dissection<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overall survival |  | From enrollment to 36 months after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Complications | The degrees of cough | 1-2 Weeks after enrollment (after Surgery) |