From ACute To Chronic Postoperative Pain in Patients for Elective Cholecystectomy

Study Overview
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Brief Summary
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Chronic Pain is a wellknown complication after cholecystectomy. Intensity of the pain in the first week after the operation is a predictive factor for the development of chronic pain, but it is unknown whether the risk is more related to one of the different components of acute pain (ie somatic, visceral, referred). Furthermore the chronic pain has not been systematically described in terms of type of pain or sensory abnormalities etc. (allodynia, hyperalgesia etc.). The purpose of the study is to examine whether intensity of components of acute pain is predictive for development of chronic pain after cholecystectomy and to characterize the chronic pain by quantitative sensory testing. DNA-samples are collected to examine genetical factors, important for perception of pain, and the development of chronic pain.

Official Title
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From Acute To Chronic Postoperative Pain in Patients for Elective Cholecystectomy: The Significance of Components of Pain

Conditions
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Pain

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients for elective cholecystectomy 18 years or older at the day of the operation Capable of speaking, reading and writing danish Exclusion Criteria: Previous abdominal operation Patients with preoperative neuropathies Patients with other diseases in the nervous system, preoperative paresthesias or other sensory disturbances.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Abdominal pain |  | 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quantitative sensory testing values in referred pain area. | Quantitative sensory testing values in referred pain area compared to contralateral side and preoperative values. The following quantitative sensory tests are performed: Cold Detection Threshold,Warm Detection Threshold, Cold Pain Threshold, Heat Pain Threshold, Mechanical detection Threshold, Mechanical Pain Threshold, Allodynia, Hyperalgesia, Wind-Up Ratio, Vibration Detection Threshold, Pressure Pain Threshold | 12 Months | 
| Abdominal pain |  | 6 months | 
| Quantitative sensory testing values in referred pain area. | Quantitative sensory testing values in referred pain area compared to contralateral side and preoperative values. The following quantitative sensory tests are performed: Cold Detection Threshold,Warm Detection Threshold, Cold Pain Threshold, Heat Pain Threshold, Mechanical detection Threshold, Mechanical Pain Threshold, Allodynia, Hyperalgesia, Wind-Up Ratio, Vibration Detection Threshold, Pressure Pain Threshold | 6 Months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Postcholecystectomy Pain, Chronic Postoperative Pain, Visceral Pain, Referred pain, Somatic pain, Quantitative Sensory Testing