Repellents as Added Control Measure to Long Lasting Insecticidal Nets

Study Overview
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Brief Summary
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The scaling up of Long Lasting Insecticidal Nets (LLIN) and the expansion of Indoor Residual Spraying (IRS) has contributed to a significant decrease of malaria worldwide. However these control methods tackle only indoor and night biting vectors. The proportion of transmission occurring outdoors and before sleeping hours or so-called residual transmission is steadily increasing and may compromise the effort towards malaria elimination. The purpose of this study is to raise evidence on the effectiveness of mass use of topical repellents in addition to LLINs in controlling malaria infections. A multidisciplinary approach will be used to collect information on the most important factors that contribute to the successful reduction of residual malaria transmission. In a first objective the epidemiological efficacy of repellents on prevalence of malaria carriers and malaria incidence will be assessed. To achieve this goal 98 communities will be randomly assigned to one of two treatment arms (LLIN and LLIN + repellent). Within a community a cross sectional random sample of 65 people will be drawn at the beginning and the end of the malaria season to obtain an estimate of the malaria prevalence. The second objective will handle the entomological efficacy and persistence of the topical repellent on malaria vectors. And lastly the acceptability, adherence and adequacy of the topical repellents will be studied in a third objective.

Official Title
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Repellents as Added Control Measure to Long Lasting Insecticidal Nets to Target the Residual Transmission in Southeast Asia: a Step Forwards to Malaria Elimination

Conditions
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Malaria

Intervention / Treatment
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* Other: Mosquito topical repellent


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All household members volunteering from selected communities Exclusion Criteria: Infants less than 2 years

Ages Eligible for Study
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Minimum Age: 2 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Topical Repellent & LLIN<br> | Other: Mosquito topical repellent<br>* Daily repellent use, before and after sleeping hours during the malaria season (6 months) in addition to the use of Long Lasting Insecticidal Nets during sleeping hours.<br>* Other names: Active ingredient: Icaridin;|
| No Intervention: Long Lasting Insecticidal Nets<br>Brand Name LLIN: Olyset Net Active ingredient: permethrin | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from baseline in malaria prevalence at 6 months | Malaria prevalence (PCR detection) will be measured in both study arms at the start and end of the malaria season for 2 consecutive years. | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Malaria incidence | Through passive RDT case detection | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Outdoor Malaria Transmission, Anopheles, Topical repellent, Early biting vector, Long Lasting Insecticidal Net (LLIN), Cambodia