Effects of Cisatracurium on Sccinylcholine-induced Fasciculations

Study Overview
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Brief Summary
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To investigate the effects of different doses of cisatracurium pretreatment on succinylcholine-induced fasciculations.

Detailed Description
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Ninety patients scheduled for laparoscopic cholecystectomies were equally randomized into three groups to receive pretreatment of 0.005, 0.01, and 0.02 mg/kg cisatracurium, respectively. General anesthesia was induced 3.5 min later, train of four stimulation was monitored 4.5 min later, succinylcholine 1.5 mg/kg was injected 5 min later, and endotracheal intubation was implemented 6.5 min later. The side effects of cisatracurium, intensity of fasciculations, intubating conditions, time and extent to maximal depression of twitch and time for its recovery to 20% of control value, severity of myalgia at 24 h postoperatively, serum potassium before cisatracurium pretreatments, at intubating time, and 5 min after intubation were recorded.

Official Title
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Effects of Pretreatment With Different Doses of Cisatracurium on Succinylcholine-induced Fasciculations

Conditions
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Fasciculations

Intervention / Treatment
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* Drug: Cisatracurium


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: American Standards Association (ASA) physical status I or II patients scheduled for elective laparoscopic cholecystectomies with tracheal intubation requiring general anesthesia; 20 - 65 years old; Without acid-base imbalance and electrolyte disturbance; With normal hepatic and renal function. Exclusion Criteria: Patients with the contraindications associated with succinylcholine or cisatracurium; Patients taking drugs known to alter the action of neuromuscular blockers; Patients with a body mass index exceeding 30

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Cisatracurium 0.005 mg/kg<br>The group received pretreatment of cisatracurium 0.005 mg/kg. | Drug: Cisatracurium<br>* Different groups received different pretreatments of cisatracurium.<br>* Other names: Dose;|
| Experimental: Cisatracurium 0.01 mg/kg<br>The group received pretreatment of cisatracurium 0.01 mg/kg. | Drug: Cisatracurium<br>* Different groups received different pretreatments of cisatracurium.<br>* Other names: Dose;|
| Experimental: Cisatracurium 0.02 mg/kg<br>The group received pretreatment of cisatracurium 0.02 mg/kg. | Drug: Cisatracurium<br>* Different groups received different pretreatments of cisatracurium.<br>* Other names: Dose;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Presence of fasciculations |  | After the injection of succinylcholine for 1.5 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Side effects of the pretreatment of cisatracurium |  | From the time of 3 minutes after the pretreatment of cisatracurium for 0.5 minutes | 
| The time to maximal depression of twitch |  | From the time of 4.5 minutes after the pretreatment of cisatracurium for two minutes | 
| The extent to maximal depression of twitch |  | From the time of 4.5 minutes after the pretreatment of cisatracurium for two minutes | 
| The grades of endotracheal intubation |  | At intubating time | 
| The changes of serum potassium |  | After entering the operating theater till the anesthesia induction, at intubating, and 5 min after intubation | 
| Myalgia at 24 hours postoperatively |  | At 24 hours postoperatively |