Role of Parasitic Infection in Inflammatory Bowel Disease and Irritable Bowel Syndrome

Study Overview
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Brief Summary
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Role of parasitic infection in Inflammatory bowel disease and Irritable bowel The burden of the parasitic disease is in-direct relation with the health and nutritional status of the host, inducing not only parasite-specific immunity but also can modify the host's immune responses . Many parasites can imitate inflammatory bowel disorders and some studies showed that infection with parasites can improve disorders like IBD or moderate the symptoms of inflammatory bowel disorders . Even though, many studies have shown that gastrointestinal infection is an important risk factor for the development of IBS

Detailed Description
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Detect the prevalence of parasite/s associated with Inflammatory bowel diseases (IBD) and Irritable bowel syndrome (IBS) in comparison with control subjects. Evaluating the effect of the parasite on the course and prognosis of the diseases. Evaluating the effect of the antiparasitic drugs on the course and prognosis of the diseases.

Official Title
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Role of Parasitic Infection in Inflammatory Bowel Disease and Irritable Bowel Syndrome

Conditions
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Parasite IBS IBD

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosis of IBD will be confirmed using standard clinical, endoscopic, radiographic and4 pathological criteria according to the Montreal classification of the extent and severity of IBD Diagnosis of IBS will depend on Rome IV criteria Recurrent abdominal pain on average at least 1 day/week in the last 3 months, associated with two or more of the following criteria: Related to defecation; Associated with a change in the frequency of stool and/ or Associated with a change in the form (appearance) of stool. Exclusion Criteria: any patient who received antipiotic or antiparasitic drug within the past 4 weeks

Ages Eligible for Study
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Minimum Age: 17 Years
Maximum Age: 69 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| IBD GROUPS<br>PATIENT WITH IBD DISEASE | |
| IBS GROUP<br>PATIENT WIT IBS DISEASE | |
| CONTROL 1<br>CONTROL WITH POSITIVE PARASITIC INFECTION AN POSITIVE GIT SYMTOMS | |
| CONTROL2<br>HEALTHY VOLUNTEARS | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Detect the prevalence of parasite/s associated with Inflammatory bowel diseases (IBD) and Irritable bowel syndrome (IBS) in comparison with control subjects. | Detect the prevalence of parasite/s associated with Inflammatory bowel diseases (IBD) and Irritable bowel syndrome (IBS) in comparison with control subjects.by making stool analysis and clinical examination | baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| measure the effect of the antiparasitic drugs on the course and prognosis of the diseases | giving the patient antiparasitic drug and measure the effect of anti parasitic drug on course and prognosis of disease | baseline |