Impact of Diverticular Disease on the Detection of Colon Adenomas

Study Overview
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Brief Summary
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Benign adenomas of the colon have the potential to degenerate and become malignant. Therefore adenomatous polyps should be detected and resected during colonoscopy. Factors like advanced age and male gender are associated with the detection of adenomas. The same epidemiological pattern can be found with regard to colon diverticula. Furthermore, western world countries report higher incidences of both colorectal carcinoma as well as diverticular disease. It is not known whether a correlation exists between both entities. Some recent data have postulated higher adenoma detection rates in patients with concomitant diverticular disease (Rondagh EJ et al. Eur J Gastroenterol Hepatol. 2011; 23:1050-5. Kieff BJ et al. Am J Gastroenterol 2004; 99: 2007-11). If a positive correlation could be found this would possibly affect recommendations regarding colonoscopy surveillance intervals for patients with and without diverticular disease. The investigators therefore plan to conduct the following trial.

Conditions
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Colon Adenoma, Diverticulosis

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: indication for colonoscopy age >= 18 years Exclusion Criteria: pregnant women patients denying written consent indication for colonoscopy: familial adenomatous polypose indication for colonoscopy: inflammatory bowel disease indication for colonoscopy: previously known colon polyp/adenoma/carcinoma history of colon surgery contraindication for resection of polyps American Society of Anesthesiologists (ASA) class IV, V or VI

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Routine colonoscopy<br>Patients receiving routine colonoscopy (for a multitude of indications) at the study centers are eligible for participation | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Adenoma detection rate | After obtaining the histopathological diagnosis of resected polyps (approximately 3 days - 2 weeks after colonoscopy ) accuracy of optical diagnosis can be determined | up to 2 weeks (participants will be followed for the duration of hospital stay or outpatient treatment, an expected average of 2 weeks) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Polyp detection rate | a maximum of one day is expected for colonoscopy | up to one day | 
| Frequency of colon diverticulosis | a maximum of one day is expected for colonoscopy | up to one day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Adenoma, Diverticular disease, Diverticulosis, Colorectal carcinoma, Polyp