Implant Placement in Mandibular Molar Xenograft Versus PRF

Study Overview
=================
Brief Summary
-----------------
20 recruited patients indicated for immediate implant placement in mandibular molar patients are divided into 2 groups each group contain 15 patients, one group assigned for placement of bovine bone after molar extraction and immediate implant placement, while the other group we use Platelet-rich fibrin as space filling material.

Official Title
-----------------
Immediate Implant Placement With Deproteinized Bovine Bone (Tutogen) Versus Placement of Platelet-rich Fibrin as a Space Filling Material in Mandibular Molars. Randomized Clinical Trial.

Conditions
-----------------
Edentulous Alveolar Ridge

Intervention / Treatment
-----------------
* Procedure: extraction,implant placement,PRF
* Procedure: Exctraction,Implant placement,Bone graft


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with non-restorable mandibular molars Both sexes - Exclusion Criteria: • Heavy smokers more than 20 cigarettes per day.5 Patients with in sufficient interseptal bone height and width Patients with systemic disease that may affect normal healing. Patients with completely resorbed buccal cortical plate.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: extraction,implant placement,PRF<br>Extraction of Mandibular first molar and Implant placement followed by Placement of placement of Platelet rich fibrin as space filling material | Procedure: extraction,implant placement,PRF<br>* Surgical extraction of mandibular molar using periotome and forceps followed by implant placement in inter-septal bone. Then a blood sample is withdrawn from patient and placed in the centrifuge. Then Platelet-Rich fibrin is placed in the extraction socket as space filling material<br>|
| Active Comparator: Exctraction,Implant placement,Bone graft<br>Extraction of mandibular first molar followed by implant placement and xenogenic bone graft as space filling material | Procedure: Exctraction,Implant placement,Bone graft<br>* Surgical extraction of mandibular molar using extraction forceps and periotome followed by implant placement in interseptal bone. De-proteinized bovine bone graft material is placed as space filling material<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patient satisfaction | evaluation of postoperative complications regarding pain and oedema | 1 week post operative | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| implant stability | measurement of implant stability using osstell device | will be measure intraopertively immediately after insertion of the implants and will be measure one more time 6 months after 1st operation at the time of exposure of implants | 
| amount of bone gained or lost around the implants | two cone beam computed tomography (CBCT) will be taken for the patient, one immediate postoperative and the other 6 months after the operation then the height of bone gained or lost around the implants will be assessed by superimposing the same section in the two CBCTS | 6 months postoperative | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Platelet rich fibrin,xenograft