linjc16/ctgov huggingface dataset:
Italian Registry On Multipoint Left Ventricular Pacing

Study Overview
=================
Brief Summary
-----------------
The IRON-MPP is a prospective multicenter, observational registry designed to collect clinical and device data from a large cohort of HF patients treated in clinical practice with a CRT-D device with the ability to deliver Multi Point Pacing. The purpose of the Registry is to collect data on how MPP-devices are being used by physicians in order to better understand how to improve the clinical care of patients and effectiveness of MPP therapy.

Official Title
-----------------
Italian Registry On Multipoint Left Ventricular

Conditions
-----------------
Heart Failure, Ventricular Fibrillation, Ventricular Tachycardia

Intervention / Treatment
-----------------
* Device: CRT-D


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: - Patients implanted with a St. Jude Medical CRT-D system with MPP capability Exclusion Criteria: - Patients currently participating in any other clinical investigation

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: CRT-D|HF patients treated in clinical practice with a CRT-D device|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Left ventricular ejection fraction | Changes in Left ventricular ejection fraction | 6 Months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Heart Failure Hospitalizations |  | 12 months | 
| Appropriate device interventions | Number of participants with appropriate device interventions (anti-tachycardia pacing or shock) | 12 months | 
| Echocardiographic changes | Left ventricular end systolic volume | 12 months | 
| QRS Duration | Changes in QSR duration between MPP and conventional biventricular pacing | Baseline and six months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
cardiac resynchronization therapy, multipoint left ventricular pacing
Prevalence of Inpatient Hyperglycemia: Risks, Complications and Outcomes

Study Overview
=================
Brief Summary
-----------------
This protocol will determine the prevalence of hyperglycemia and diabetes in the elective orthopedic population at the University of Wisconsin. It will also determine if there is a difference in outcomes. The study hypothesizes that at least 10% of patients will have some degree of impaired glucose regulation that has previously been undiagnosed.

Official Title
-----------------
Prevalence of Inpatient Hyperglycemia: Risks, Complications and Outcomes

Conditions
-----------------
Diabetes Mellitus, Diabetes Complications

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Ages 18 years or older Undergoing elective total knee, hip or lumbar spinal surgery Exclusion Criteria: Pregnancy Unable to give consent

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Preoperative orthopedic<br>Patients undergoing elective total hip, knee and spinal surgery at University of Wisconsin hospital, having their preoperative visit between December 1, 2007 and November 30, 2008. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prevalence of Hyperglycemia in the Elective Orthopedic Population | Number of orthopedic patients that have elevated fasting blood glucose levels preoperatively | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prevalence of Undiagnosed Diabetes in the Elective Orthopedic Population. |  | 1 year | 
| Prevalence of Adverse Outcomes in the Hyperglycemic Elective Orthopedic Population. |  | 1 year |
The Dose of Sugammadex for Rapid Reversal of Profound Neuromuscular Block in Young and Elderly Patients

Study Overview
=================
Brief Summary
-----------------
To find out the dose of sugammadex for recovery of the TOF ratio to 0.9 within 2 minutes from profound rocuronium-induced neuromuscular block in young and elderly adult patients.

Detailed Description
-----------------
A previous study reported that elderly patients required a longer time to recover from rocuronium induced neuromuscular block compared to younger patients. Therefore, the aim of this study is to find out the dose of sugammadex for rapid recovery from profound neuromuscular block in young and elderly adult patients.

Conditions
-----------------
Anesthesia Recovery Period, Neuromuscular Blockade

Intervention / Treatment
-----------------
* Drug: Sugammadex


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 20-40 years or ≥70 years ASA class I-II patients who received surgery less than 2 hours. Exclusion Criteria: anticipated difficult intubation neuromuscular, hepatic or renal disorders drug allergy body mass index >30 kg/m2 or body mass index <18 kg/m2 emergency surgery

Ages Eligible for Study
-----------------
Minimum Age: 20 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Young adults<br>To find out the the dose of sugammadex for recovery of the TOF ratio to 0.9 within 2 minutes from profound neuromuscular block : Dixon's up-and-down method | Drug: Sugammadex<br>* The dose of sugammadex<br>|
| Experimental: Elderly adults<br>To find out the the dose of sugammadex for recovery of the TOF ratio to 0.9 within 2 minutes from profound neuromuscular block : Dixon's up-and-down method | Drug: Sugammadex<br>* The dose of sugammadex<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The dose of sugammadex for recovery of the TOF ratio to 0.9 within 2 minutes from profound neuromuscular block |  | 2 hour |
Compliance and Persistence With Osteoporosis Treatment and Attitude Towards Future Therapy Among Post-menopausal Israeli Women During Drug Treatment or Drug Holiday

Study Overview
=================
Brief Summary
-----------------
The purpose of the study is to provide information about the rate of response and persistence to drug therapies for osteoporosis. Another issue examined in this study refers to the preferences and concerns about future treatments in patients during drug holiday.

Official Title
-----------------
Compliance and Persistence With Osteoporosis Treatment and Attitude Towards Future Therapy Among Post-menopausal Israeli Women During Drug Treatment or Drug Holiday: Data From a Single Outpatient Endocrine Clinic.

Conditions
-----------------
Osteoporosis

Intervention / Treatment
-----------------
* Other: Questionnaires about compliance and persistence with bisphosphonates treatment


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Postmenopausal women Diagnosis of osteoporosis in the medical record At least one prescription drug to treat osteoporosis in the last 5 years Insured by Clalit Health Services Hebrew-speaking capability and readiness to answer a questionnaire Exclusion Criteria: Premenopausal women No diagnosis of osteoporosis in the medical record No treatment for osteoporosis in the last 5 years Women who do not speak Hebrew or are unable to answer a questionnaire

Ages Eligible for Study
-----------------
Minimum Age: 40 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Postmenopausal women<br>Postmenopausal women treated with bisphosphonates | Other: Questionnaires about compliance and persistence with bisphosphonates treatment<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Compliance and persistence to osteoporosis drug therapy | Data collection will be done by questionnaires and from the medical record of the patient. The information collected will include: demographic information, measurements of bone density, additional information about the disease and treatment that the patient receives,prescription purchases and additional drugs the patient is taking (steroids, PPI's(Proton Pump Inhibitors) / H2 receptor antagonists and NSAIDs(Non Steroidal Anti Inflammatories)). | Participants will be followed for the duration of their clinic visit, an average of 5 hours | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
osteoporosis, postmenopausal, patient compliance, compliance, diphosphonates, bisphosphonates
Appendicitis in Adults and Children in France-A Prospective Study by the French Surgical Association Multicenter Cohort

Study Overview
=================
Brief Summary
-----------------
Acute appendicitis still represents a surgical challenge, despite profound changes in practice in recent decades. The objective of this study was comprehensively document current surgical practices aimed at improving the management and follow-up of pediatrics and adults patients presenting with appendicitis in France.

Detailed Description
-----------------
The APPEA series is a national multicentric prospective cohort that included children and adults in France with acute appendicitis presenting between March 1st and June 30th, 2016. Data included demographic characteristics, medical history, symptoms, biology, radiology, treatments given during hospitalization, the modalities of the intervention, and any complications during a follow-up period of 6 months.

Official Title
-----------------
Current Management of Appendicitis in Adults and Children in France-A Prospective Study by the French Surgical Association Multicenter Cohort (APPEA)

Conditions
-----------------
Appendicitis Acute, Peritonitis

Intervention / Treatment
-----------------
* Other: evaluation of practices


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients admitted for appendicitis in participating centers informed Exclusion Criteria: patient's (or parent's for children) opposition
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: evaluation of practices|Study of the management and follow-up of patients presenting with appendicitis in France.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Surgical practices in the management of adults and pediatrics patients with appendicitis | Rate of laparoscopic surgery | 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
laparoscopic surgery
Safety and Performance Study of the CardioGard Cannula

Study Overview
=================
Brief Summary
-----------------
The objective of the study is to collect additional information related to the safety and performance of the CardioGard Cannula during bypass procedures.

Official Title
-----------------
A Study to Collect Additional Information Related to the Safety and Performance of the CardioGard Cannula

Conditions
-----------------
Aortic Valve Replacement

Intervention / Treatment
-----------------
* Device: Aortic Cannulas (CardioGard)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: AVR (Aortic Valve Replacement), AVR+CABG (Coronary Artery Bypass Surgery) Non pregnant female Exclusion Criteria: Contraindication for open heart surgery under bypass machine Emergency Operation

Ages Eligible for Study
-----------------
Minimum Age: 50 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: CardioGard Cannula<br> | Device: Aortic Cannulas (CardioGard)<br>* Comparison of aortic cannulas during by pass surgery<br>|
| Active Comparator: Reference Cannula<br> | Device: Aortic Cannulas (CardioGard)<br>* Comparison of aortic cannulas during by pass surgery<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| DWI- Diffusion Weighted Imaging | diffusion weighted magnetic resonance imaging (DW-MRI) | The outcome measure is assessed in average a week after the surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| TCD- Transcranial Doppler |  | The Outcome measure is assessed during the surgery | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
bypass, cannula
The Effect of a Vegan Alginate Product on Athletes Recovery and Performance

Study Overview
=================
Brief Summary
-----------------
The feeding strategies during recovery are essential to optimize a subsequent performance. Carbohydrate is a major fuel source during exercise as it has been shown to maintain high rates of carbohydrate oxidation. Protein intake in combination with carbohydrate have been shown to increase Amino acid bioavailability and may alter physiologic responses during exercise, which may be relevant to endurance performance. The goal of this study is to assess the effect of a new developed vegan product on athletes recovery and subsequent performance.

Official Title
-----------------
The Effect of a Vegan Alginate Product on Athletes Recovery and Performance

Conditions
-----------------
Athletic Performance

Intervention / Treatment
-----------------
* Dietary Supplement: CHO+PRO
* Dietary Supplement: CHO


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: males between 18-50 years of age moderate to trained individuals with a VO2max > 50 ml/min/kg Exclusion Criteria: persons diagnosed with metabolic diseases (i.e. Type 2 Diabetes) which relates to the carbohydrate metabolism. persons ingesting prescribed drugs/medicin, supplements or a special diet (i.e. low carbohydrate), which might affect the glykogen synthesis and/or performance.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Vegan product<br> | Dietary Supplement: CHO+PRO<br>* A vegan product containing carbohydrate and protein<br>|
| Active Comparator: Control<br> | Dietary Supplement: CHO<br>* containing carbohydrate<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Performance | Time-to-exhaustion. Measured by the duration of high intensity exercise performed to exhaustion. | Aprox. 120 minutes |
A Trial to Evaluate the Precision and Accuracy of the NBM-200 Series When Used in a Continuous Prospective Mode

Study Overview
=================
Brief Summary
-----------------
The purpose of the study is to define the precision, accuracy and variability of the NBM-200 system in non invasive blood Hemoglobin (Hb) measurements relative to the laboratory blood analyzer by comparing two consecutive Hb values obtained by the NBM system to venous values.

Detailed Description
-----------------
Each subject will be placed in a comfortable position in a temperature regulated room. Participants will have two consecutive non invasive (NBM) measurements taken which involves inserting the thumb into a ring shaped sensor. After each non invasive measurement the sensor will be removed. Each measurement takes approximately 85 seconds and involves the finger cuff inflating (to over systolic pressure) and deflating several times in quick successions in order to measure and calculate the Hb values. The two non invasive measurements will be performed using the same finger. After the NBM system testing is complete and recorded, the subject will have a venous (venipuncture) blood sample collected in order to provide two blood tests performed on two different models of routine automated complete blood count or Hb blood analyzers. Addendum: Reproducibility Procedure (optional) Each subject will be measured by each one of the three operators, three NBM system units, 3 times consecutively (without removal) on his right thumb and right index finger. The order of each measurement sequence will be randomized (thumb/index). There will be an intermission of 3 to 5 minutes between the 3 measurement sets taken on each participant. In case of a longer intermission, the subject will be measured again and the previous results will be excluded.

Official Title
-----------------
A Trial to Evaluate the Precision and Accuracy of the NBM-200 Series When Used in a Continuous Prospective Mode

Conditions
-----------------
Anemia

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Aged 18 years and over Healthy volunteers Anemia patients Exclusion Criteria: Participants under the age of 18 years Patients with significant deformity, degenerative changes or oedema of the thumb or index fingers Patients with localized infection, ulceration or skin breaks involving the fingers Patients with vascular disease or Raynaud's phenomenon affecting the fingers Participants who are unable to give informed written consent Pregnancy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 95 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Compare the Hb values from the Noninvasive Blood Monitor(NBM200) series against the Hb from the lab blood analyser on healthy volunteers and oncology patients |  | 1 day |
Use of Discarded Surgery Human Tissue Specimens for Basic Science Research

Study Overview
=================
Brief Summary
-----------------
Although it is now established that calcification process result from the joint and coordinated action of different cell types, many areas of shadow remain regarding the spatio-temporal implementation of these events. Highlighting these processes requires additional research to consider new approaches to clinical management of patients with such conditions. It is in this context that the investigators need to use residual human tissue fragments resulting from surgery which are not intended to be used for clinical-biological management of patients. The use of these pseudonymised human tissues will allow the investigators to conduct in vitro cell culture experiences.

Official Title
-----------------
Use of Discarded Surgery Human Tissue Specimens for Basic Science Research

Conditions
-----------------
Osteoblast, Vascular Calcification

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients undergoing surgery in the Cardiac Surgery and Orthopedic Surgery departments of the CHU Amiens-Picardie patients who will be beforehand informed patients who will not be opposed to this study. Exclusion Criteria: HIV and hepatitis positive patients

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Success in establishment of Cell Culture Systems from discarded surgery specimens | Success in establishment of Cell Culture Systems from discarded surgery specimens | 5 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
osteoblast, Vascular Calcification, vascular smooth muscle cell, Cardiac valve calcification, Valvular interstitial cell, bone tissue
The Microbiological Spectrum in Acute Dacryocystitis

Study Overview
=================
Brief Summary
-----------------
Acute dacryocystitis in adults can be a very painful disease and may not respond well to medical therapy. The purpose of this prospective non-randomised study is to determine the microorganisms causing acute dacryocystitis and the antibiotic sensitivities of these organisms. The study also aims to correlate the microbiological findings to the severity of clinical manifestations and evaluate the effectiveness of our current practice of aspiration and empiric systemic antibiotic therapy in treating patients with acute dacryocystitis and hence review whether there is a need to alter current management strategy.

Conditions
-----------------
Dacryocystitis

Participation Criteria
=================
Eligibility Criteria
-----------------
INCLUSION CRITERIA: Painful localised fluctuant induration just inferior to the medial canthal tendon of less than 2 weeks duration. EXCLUSION CRITERIA: Non-fluctuant lacrimal sac swelling Uncooperative patient Unwilling Patient

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |