linjc16/ctgov huggingface dataset:
Influence of Direction of Movement While Walking

Study Overview
=================
Brief Summary
-----------------
The aim of the study is evaluation of cerebral blood flow (based on testing the rate of flow in middle cerebral arteries by transcranial Doppler ultrasound) during different forms of walking training - walk forwards and backwards, with closed and open eyes.

Detailed Description
-----------------
In the third minute of training walking a significant increase in blood flow velocity was recorded, both in right and left middle cerebral arteries. It was observed in the left artery during all forms of training. In the right artery it occurred only during three forms of difficult training, and was preceded by significant decrease in blood flow in the first minute of the gait with eyes closed. The output values of the rate of blood flow in both right and left middle cerebral arteries became progressively reduced in the successive stages of gait. Pressure and pulse rates did not correlate with the variables of blood flow velocity in middle cerebral arteries.

Official Title
-----------------
Influence of Direction of Movement While Walking Upon the Blood Flow Rate Through Brain, Examined by Transcranial Doppler Sonography in Young Healthy Subjects.

Conditions
-----------------
Changes in Blood Flow to the Brain, Changes Depending on the Form of Walking

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: healthy subjects without brain disease Exclusion Criteria: brain disease and walking disfunctions

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 24 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| examining group<br>20 healthy subjects (11 men, 9 women, average age 23.94) | |
| control group<br>6 healthy subjects (3 men, 3 women, average age 23.6) | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Transcranial Doppler sonography in young healthy subjects. | Significant changes in blood flow to the brain depending on the form of walking and its conditions were observed. Changes in the right middle cerebral artery were more diverse than in the left artery. Difficulty in walking training forms gave long-term vasodilation. | 5 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
blood flow in the middle cerebral artery of brain
Prospective Database for Colonic or Rectal Resection Surgery Patients

Study Overview
=================
Brief Summary
-----------------
Colorectal cancer is the third most common cancer in men, after prostate and lung cancer. It represents 11.2% of all new cases of male cancer. In women, this cancer is the second most common after breast cancer (11.3% of all new cases of female cancer).

Detailed Description
-----------------
Colorectal cancer is the second leading cause of cancer death in France. It accounts for nearly 12% of all cancer deaths, especially among those 65 and over. However, mortality has declined steadily since 1980. Access to screening for colorectal cancer and resection of precancerous lesions partly explains this decline. All sexes combined, it is estimated that about one in five colorectal cancer is diagnosed at a limited local stage. The treatment is then less heavy and gives better results. With the development of Enhanced Recovery After Surgery (ERAS) protocols and their extension to rectal excision, it becomes imperative to be able to collect operative data from these patients on a perennial basis for the purpose of evaluating our results. Finally, the evaluations resulting from this database could have prognostic value and ultimately allow us to adapt the surgical management of the patient according to the results.

Official Title
-----------------
Prospective Database for Colonic or Rectal Resection Surgery Patients

Conditions
-----------------
Colorectal Disorders

Intervention / Treatment
-----------------
* Other: obsevation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients treated for colonic and / or rectal resection in the oncological digestive surgery department of the Paoli-Calmettes Institute, Patients over 18 years old, Affiliation to a social security scheme, or beneficiary of such a scheme.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: obsevation|prospective data collection for colonic or rectal surgery|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| clinical events | to asses postoperative effects of colonic or rectal excision by collecting clinical events | 5 years |
Administration of Allogenic Red Blood Cells Loaded L-asparaginase in Cases of Relapse of Acute Lymphoblastic Leukaemia

Study Overview
=================
Brief Summary
-----------------
Primary objective : To explore the relation between 3 doses of GRASPA and duration of asparagine depletion (< 2µmol/l) Secondary objective : Pharmacokinetic / Pharmacodynamic parameters toxicity Study duration : 2 years Study treatment : Red blood cells loaded with L asparaginase versus native L asparaginase Associated treatments : COPRALL chemotherapy Randomization : centralised randomisation on scratching list

Official Title
-----------------
Administration of Allogenic of Red Blood Cells Loaded L Asparaginase in Acute Lymphoblastic Leukemia Relapse.

Conditions
-----------------
Acute Lymphoblastic Leukemia

Intervention / Treatment
-----------------
* Biological: GRASPA
* Biological: GRASPA
* Biological: GRASPA
* Drug: native L asparaginase


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Subject between 1 and 55 year old Subject with acute lymphoblastic leukaemia or lymphoblastic lymphoma (excluded burkitt lymphoma) who have relapsed after first remission (medullary or SNC relapse) Or patient who still refractory to first line chemotherapy for an ALL Patient who gave written informed consent (2 parents for children) Exclusion Criteria:

Ages Eligible for Study
-----------------
Minimum Age: 1 Year
Maximum Age: 55 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br> | Biological: GRASPA<br>* 50 UI/Kg<br>|
| Experimental: 2<br> | Biological: GRASPA<br>* 100 UI/Kg<br>|
| Experimental: 3<br> | Biological: GRASPA<br>* 150 UI/Kg<br>|
| Active Comparator: 4<br> | Drug: native L asparaginase<br>* 10000UI/m2, 14 infusions during 4 chemotherapy cycle<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Duration of plasmatic asparagin depletion (< 2µmol/l) |  | PK points | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Relapse, Lymphoma lymphoblastic
Automated Chest Compression in Cardiac Arrest

Study Overview
=================
Brief Summary
-----------------
To evaluate the effect of use of automated chest compression device on blood pressure in patients presenting with cardiac arrest. Higher systolic, diastolic and mean blood pressures are expected.

Detailed Description
-----------------
The protocol compares arterial pressures produced by an automated self-adjusting load-distributing band device (AutoPulse™ 100, Zoll®) with those of manual cardiopulmonary resuscitation in refractory out-of-hospital cardiac arrest. Each patient will receive first manual compressions and then automated resuscitation. Patients presenting with cardiac arrest are treated following standard advanced life support guidelines. They are intubated and ventilated, received epinephrine and defibrillation if appropriate. Manuel chest compressions are continued. An arterial catheter is placed to monitor hemodynamics continuously as we usually do in this case. Patients are included at this stage. Three blood pressure values (every 1 minutes) are recorded. Then, the automated band device is started up without any pause, following our procedure for refractory cardiac arrest. Three blood pressure values are recorded again, during automated cardiopulmonary resuscitation.

Official Title
-----------------
Effect on Hemodynamics of Automated Band Chest Compression Device in Cardiac Arrest Resuscitation

Conditions
-----------------
Cardiac Arrest

Intervention / Treatment
-----------------
* Device: Automated load-distributing band device


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age ≥ 18 Refractory cardiac arrest Exclusion Criteria: Defective invasive arterial blood pressure monitoring

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: Automated load-distributing band device|Blood pressure recording before and after starting up the automated band device|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diastolic blood pressures produced by manual and then by automated chest compressions will be recorded for each patient |  | Instantaneously | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Systolic blood pressures produced by manual and then by automated chest compressions will be recorded for each patient |  | Instantaneously | 
| Mean blood pressures produced by manual and then by automated chest compressions will be recorded for each patient |  | Instantaneously | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Cardiac arrest, Cardiopulmonary resuscitation
Efficiency of an Educational Program for Informal Caregivers of Hospitalized, Dependent Patients: Cluster Randomised Trial

Study Overview
=================
Brief Summary
-----------------
The aim was to assess whether nursing interventions based on Health Educational Programs for primary informal caregivers of dependent patients may improve their quality of life, decreasing emotional burden and increasing caregiving knowledge, in order to better meet patients' basic needs.

Conditions
-----------------
Dependence, Dementias

Intervention / Treatment
-----------------
* Other: Health education intervention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Primary informal caregivers of dependent patients, admitted in 30 hospital units, with expected hospital stays of at least one week. A dependent patient is understood to require the aid of someone else in order to carry out basic daily activities. Exclusion Criteria: caregivers with cognitive deficits that could be an obstacle for adequate verbal understanding, illiteracy, persons taking part in other clinical trials or who had taken part in similar workshops in the previous two years, as well as health professionals.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: healtn education<br>one group received an educational program | Other: Health education intervention<br>* 'Health education intervention'<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| life quality |  | Data were evaluated with an average one month after discharge, a maximum in September 2009 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Caregiver´s burden |  | Data were evaluated with an average one month after discharge, a maximum in September 2009 |
Investigating Burnout in Intensive Care in Middle Incoming Turkey

Study Overview
=================
Brief Summary
-----------------
Turkey is a developing country and its intensive care infrastructure is worse than developed countries. The staff is very busy at work. Intensive care has become a new science. We wanted to investigate burnout syndrome among physicians and other health care workers who are starting to work at a new intensive care medicine. Intensive care specialists in Turkey do not work in intensive care centers where they want. This may have a negative effect on physicians.

Detailed Description
-----------------
Burnuot health practices are more common than the normal group. The data about Turkey are limited. In developing societies, there are often no protocols in intensive care. There are no teams again during intensive care. All work is done by physicians and other health workers. This may adversely affect health care workers. Intensive care science is new. The training first started in 2013. The newly graduated heavy-duty specialists can work where they do not want. The workload of the health workers working in the intensive care unit is high. We wanted to investigate burnout on healthcare workers in Turkey.

Official Title
-----------------
Investigating Burnout in Intensive Care in Middle Incoming Turkey

Conditions
-----------------
Burnout Syndrome

Intervention / Treatment
-----------------
* Behavioral: Investigating Burnout in Intensive Care in Middle Incoming Turkey


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: fellow, nursing, specialist and academics working intensive care medicine Exclusion Criteria:

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: Investigating Burnout in Intensive Care in Middle Incoming Turkey|single-group studies|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| maslach burnout inventory measure |  | 20 day |
Observational Retrospective Study on Treatment and Outcomes in Patients With Low-grade Serous Ovarian Cancer

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to retrospectively evaluate treatments and outcomes of patients with low grade serous ovarian carcinomas in Italy.

Official Title
-----------------
Observational Retrospective Study on Treatment and Outcomes in Patients With Low-grade Serous Ovarian Cancer

Conditions
-----------------
Low-grade Serous Ovarian Carcinoma, Recurrent Invasive Borderline Serous Ovarian Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosis low-grade serous ovarian carcinoma OR invasive recurrence after surgical resection of borderline serous ovarian carcinoma Availability of archival tumor specimen (paraffin embedded block) for central analysis and evaluation for mutations Age > 18 years Signed informed consent Exclusion Criteria: High-grade serous, mucinous, endometrioid, or any other non-low-grade serous ovarian carcinoma Unavailability of archival tumor specimen

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Single cohort<br>Retrospective analysis of all patients diagnosed, from 01/01/2000 to 01/01/2014, with low-grade serous ovarian cancer or invasive recurrence after surgery for borderline serous carcinoma | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| risk of recurrence in patients with low-grade serous ovarian carcinoma |  | two years | 
| number of patients with objective tumor response after receiving chemotherapy |  | 6 months | 
| number of patients with objective tumor response after receiving hormone therapy |  | 6 months | 
| number of patients with objective tumor response after receiving combination hormonal and chemotherapy |  | 6 months | 
| progression free survival |  | 2 years | 
| overall survival |  | 5 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
chemotherapy, hormone therapy, borderline, low-grade, serous ovarian cancer
A Phase 4 Study With Tamsulosin OCAS to Assess Nighttime Voiding.

Study Overview
=================
Brief Summary
-----------------
Randomized, double-blind, placebo-controlled study with two treatment arms (Tamsulosin OCAS 0.4 mg & placebo). The study comprises a 2-week placebo run-in followed by a 12-week treatment period.

Official Title
-----------------
A Randomized, Double-blind, Placebo-controlled Study to Assess the Effect of Tamsulosin OCAS 0.4 mg Tablets, Once Daily on Nocturia, Compared to Placebo, in Patients With Lower Urinary Tract Symptoms Associated With Benign Prostatic Hyperplasia

Conditions
-----------------
Benign Prostatic Hyperplasia

Intervention / Treatment
-----------------
* Drug: Tamsulosin OCAS
* Drug: Placebo


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosed as having LUTS associated with BPH On average, at least 2 voids per night over the last week A maximum of 4 hours of undisturbed sleep expected per night (night time is defined as the time from going to bed with the purpose of sleeping until waking up with the purpose of getting up) Exclusion Criteria: Subject is currently taking diuretics Subjects who work shift hours and whose hours of work include any time between 23.00 and 06.00h

Ages Eligible for Study
-----------------
Minimum Age: 45 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: 1<br>Tamsulosin OCAS tablet | Drug: Tamsulosin OCAS<br>* Adrenoceptor antagonist<br>|
| Placebo Comparator: 2<br>Placebo tablet | Drug: Placebo<br>* placebo<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The change from baseline to week 12 in mean number of nocturnal voids |  | 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The change from baseline to week 12 in mean hours of undisturbed sleep, defined as the time from falling asleep to first awakening to void |  | 12 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Benign Prostatic Hyperplasia, Nocturia, Actigraphy, Tamsulosin
The Effect of Floorball on Health and Performance in Subjects With Lifestyle Diseases

Study Overview
=================
Brief Summary
-----------------
To investigate the effect of floorball on health and performance in subjects with either type 2 diabetes or cardiovascular diseases.

Official Title
-----------------
The Effect of Floorball on Health Parameters and Performance in Subjects With Lifestyle Diseases

Conditions
-----------------
Type2 Diabetes, Cardiovascular Diseases

Intervention / Treatment
-----------------
* Behavioral: Floorball


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosed with type 2 diabetes Diagnosed with a cardiovascular disease (bp >140/90mmHg) Physical activity <2 hours pr. week. Not participating in any regular physical activity the last 2 years Exclusion Criteria: age <18 years Injuries that prevent the subject from playing floorball Type 1 diabetics Alcohol >14 units pr. week. Pregnancy Participation in other scientific studies Abuse of illegal drugs other known serious diseases

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Floorball<br>The subjects in this group are set to play floorball three times pr. week for 39 weeks. | Behavioral: Floorball<br>* This intervention will have one week of testing before the first 12 weeks of floorball, followed by one week of testing before the last 27 week training period.<br>|
| No Intervention: Control<br>This group functions as a control group, that will continue the normal lifestyle throughout the study. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| HbA1c | Long term blood sugar concentration | Changes from baseline measured after 12 weeks and 39 weeks | 
| Blood pressure |  | Changes from baseline measured after 12 weeks and 39 weeks |