REal World Information on Cardiovascular Drug Management Patterns in Acute Coronary Syndrome paTients

Study Overview
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Brief Summary
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RE-ACT is a national, multi-centre, observational, prospective, longitudinal cohort study which will include patients hospitalized for ACS within 24 hours of symptom onset and who have a final diagnosis of ST-segment elevation myocardial infarction (STEMI) or non-ST-segment elevation myocardial infarction (NSTEMI). This study aims to describe the short-term (at the end of the first month after index event) antithrombotic management patterns in a real-life setting for patients hospitalized with an acute coronary syndrome.

Official Title
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REal World Information on Cardiovascular Drug Management Patterns in Acute Coronary Syndrome paTients

Conditions
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Acute Coronary Syndrome

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Provision of subject informed consent Patients hospitalized and diagnosed with STEMI or NSTEMI Hospitalized within 24 hours of onset of symptoms or transferred from another hospital within 24 hours of the onset of symptoms Exclusion Criteria: STEMI and NSTEMI precipitated by or as a complication of surgery, trauma, or GI bleeding or post-PCI. STEMI and NSTEMI occurring in patients already hospitalized for other reasons. Presence of any condition/circumstance which in the opinion of the investigator could significantly limit the complete follow up of the patient (e.g. tourist, non-native speaker or does not understand the local language, psychiatric disturbances).

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with STEMI and NSTEMI<br>Patients aged 18 years or older, hospitalized and diagnosed with STEMI (ST-segment elevation myocardial infarction) or NSTEMI (non-ST-segment elevation myocardial infarction) within 24 hours of symptom onset. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Short-term antithrombotic management patterns (AMPs) in a real-life setting for patients hospitalized with an ACS | Descriptive statistics will be calculated for this outcome measure using frequency tables (n, frequency and percentage). Antithrombotic management patterns will be grouped taking into account only the different treatment options shown by the descriptive analysis. | Baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Variations in the acute clinical management strategies and AMPs. | Descriptive statistics will be calculated for this outcome measure using frequency tables (n, frequency and percentage). | Baseline | 
| Impact of the different AMPs on quality of life at discharge from hospital (using EuroQoL-5D). | Descriptive statistics will be calculated for this outcome measure using frequency tables (n, mean, median, standard deviation, minimum and maximum) | Baseline | 
| Impact of the different AMPs on quality of life at the end of the first month after discharge from the hospital (using EuroQoL-5D). | Descriptive statistics will be calculated for this outcome measure using frequency tables (n, mean, median, standard deviation, minimum and maximum) | At the end of the first month after index event | 
| Determinants of AMP choices (i.e. patient's characteristics, hospital characteristics, coronary intervention strategies and type of coronary stents used) | Descriptive statistics will be calculated for this outcome measure using frequency tables (n, frequency and percentage). | Baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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acute coronary syndrome, antithrombotic management patterns,quality of life, acute clinical management strategies