Thrombus Imaging and Treatment Analytics in Neurology

Study Overview
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Brief Summary
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In the present study, the investigators use high-resolution MR vessel wall imaging, and select patients with cerebral and cervical artery occlusion to investigate the relationship between the imaging appearance of thrombus and the various outcome of recanalization treatment.

Detailed Description
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Cerebral ischemic stroke resulting from thrombosis causes high disability and mortality. There are few biomarkers to evaluate arterial thrombophilia until now. Previous studies have demonstrated that atherosclerotic plaque rupture and erosion are major etiologies initiating thrombosis. Based on previous works targeting the role of plaque and blood flow in cerebrovascular disease, in the present study, the investigators use high-resolution MR vessel wall imaging, and select patients with cerebral and cervical artery occlusion to explore the relationship between the imaging appearance of thrombus and the various outcome of recanalization treatment. The study's objective was to solve the challenges in the mechanism of thrombus features and the outcome of recanalization therapy, thus helping improve the primary and secondary prevention of cerebrovascular disease.

Official Title
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Thrombus Imaging and Treatment Analytics in Neurology

Conditions
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Thrombus, Brain, Thrombosis

Intervention / Treatment
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* Diagnostic Test: thrombus imaging appearance


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age ≥ 18 years Extracranial and/or intracranial artery occlusion confirmed by angiography Available for magnetic resonance high-resolution vessel wall imaging Written informed consent obtained Exclusion Criteria: Extracranial and/or intracranial artery mild to moderate stenosis Pregnant women Restenosis or occlusion after artery stenting placement

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: thrombus imaging appearance|Imaging appearance of intracranial and/or extracranial arterial thrombus|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of Successful Recanalization | Antegrade blood flow through the recanalized portion was assessed by thrombolysis in myocardial infarction (TIMI) score or thrombolysis in cerebral infarction (TICI) score. TIMI≥2 or TICI≥2b was defined as successful recanalization. | 1-3 Years | 
| Ischemic Stroke Occurrence | Ischemic stroke occurrence during follow-up period which was confirmed by neuroimaging | 1-3 Years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of Participants with Adverse Events | hemorrhagic or ischemic stroke after recanalization treatment | 1-3 Years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Thrombus, Neuroimaging, High-resolution vessel wall imaging, Cerebral ischemia, Cerebral artery