Congenital Cataract Morphological Classifications

Study Overview
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Brief Summary
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Photography is considered as one of the most important means to promote evidence-based medical practice in pediatric ophthalmology.This study is to investigate the feasibility of congenital cataract morphological classifications and monitoring using slit-lamp-adapted anterior segmental photography in a large cohort that included uncooperative children.

Detailed Description
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Lens opacities in congenital cataracts have a wide range of presentations.Therefore, it is important to find a method of recording, classifying and monitoring cataract morphologies that is feasible and safe in a large cohort of children with congenital cataracts, including uncooperative children. Photography is considered as one of the most important means to promote evidence-based medical practice in pediatric ophthalmology. In this study, the investigators studied congenital cataract morphological classifications and monitoring using slit-lamp-adapted anterior segmental photography and evaluated its safety and feasibility in pediatric cataract patients registered in the Childhood Cataract Program of the Chinese Ministry of Health.

Official Title
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Congenital Cataract Morphological Classifications and Monitoring Using Slit-Lamp-Adapted Photography in CCPMOH

Conditions
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Congenital Cataract

Intervention / Treatment
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* Procedure: slit-lamp-adapted anterior segmental photography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Children with pediatric unilateral/bilateral cataracts Children who were younger than 10 years of age Exclusion Criteria: Premature birth Microphthalmia Micro-or Megalocornea Keratoconus Glaucoma Traumatic or complicated cataracts Vitreous and retinal diseases Any previous surgeries, and contraindication for pupil dilation and sedation

Ages Eligible for Study
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Maximum Age: 10 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: eligible patients group<br> | Procedure: slit-lamp-adapted anterior segmental photography<br>* The eligible patients underwent pupil dilation and slit-lamp-adapted anterior segmental photography to electronically record and monitor the morphology of their cataractous lens.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Congenital Cataract Morphological Classifications and Monitoring using Slit-Lamp-Adapted Photography | All eligible pediatric patients underwent pupil dilation with compound tropicamide eye drops 3 times (1 time every 10 minutes) before the examination or administration of sleep aid medicine. Then, the children underwent slit-lamp-adapted anterior segmental photography (BX900, Haag-Streit AG, Köniz, Switzerland) for each cataractous lens, including one diffuse light photo, one slit-light photo across the cataract and one retro-illumination photo. All photos of the included patients were screened and morphologically classified separately by two pediatric ophthalmologists; a third ophthalmologist was masked and required to make a decision if the first two physicians had different opinions. | baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Congenital cataracts, Opacity location, Opacity shape, Classification, Clinical applicability