Plasticity of Neonatal Neuronal Networks Temporal Theta Activity, the First Endogenous

Study Overview
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Brief Summary
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Temporal theta slow-wave activity (TTA-SW) in premature infants is a specific signature of the early development of temporal networks, as it is observed at the turning point between non-sensory driven spontaneous local processing and cortical network functioning. The role in development and the precise location of TTA-SW remain unknown. Previous studies have demonstrated that preterms from 28 weeks of gestational age (wGA) are able to discriminate phonemes and voice, supporting the idea of a prior genetic structural or activity-dependent fingerprint that would prepare the auditory network to compute auditory information at the onset of thalamocortical connectivity. They recorded TTA-SW in 26-32 wGA preterms. The rate of TTA-SW in response to click stimuli was evalu- ated using low-density EEG in 30 preterms. The sources of TTA-SW were localized by high-density EEG using different tissues conductivities, head models and mathematical models.

Detailed Description
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Temporal theta slow-wave activity (TTA-SW) in premature infants is a specific signature of the early development of temporal networks, as it is observed at the turning point between non-sensory driven spontaneous local processing and cortical network functioning. The role in development and the precise location of TTA-SW remain unknown. Previous studies have demonstrated that preterms from 28 weeks of gestational age (wGA) are able to discriminate phonemes and voice, supporting the idea of a prior genetic structural or activity-dependent fingerprint that would prepare the auditory network to compute auditory information at the onset of thalamocortical connectivity. They recorded TTA-SW in 26-32 wGA preterms. The rate of TTA-SW in response to click stimuli was evalu- ated using low-density EEG in 30 preterms.

Official Title
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Plasticity of Neonatal Neuronal Networks in Very Premature Infants: Source Localization of Temporal Theta Activity, the First Endogenous Neural Biomarker, in Temporoparietal Areas

Conditions
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Premature Birth

Intervention / Treatment
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* Other: ElectroEncephaloGraphy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: healthy premature infants Gestational Ages of 26 and 32 wGA Exclusion Criteria: unhealthy premature infants
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 13 high<br>High-Density ElectroEncephaloGraphy analysis of 13 healthy premature infants | Other: ElectroEncephaloGraphy<br>* Density ElectroEncephaloGraphy analysis<br>|
| 15 low<br>Low-Density ElectroEncephaloGraphy analysis of other 15 healthy premature infants | Other: ElectroEncephaloGraphy<br>* Density ElectroEncephaloGraphy analysis<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| specific temporal TTA-SW | The objective of this study is to evaluate the spatial organization of the specific Temporal theta slow-wave activity (TTA-SW) with the Low-Density Electroencephalography (LD-EEG) at an early stage of development in humans to demonstrate that TTA-SW were independent of auditory stimuli. | 2 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Temporoparietal Areas, Neural Biomarker