The Effect of High and Low Roasted Coffee on Vascular Response

Study Overview
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Brief Summary
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Evidence suggests that a diet rich in plant phenolic compounds may induce beneficial vascular effects. Coffee is a good source of phenolic compounds called chlorogenic acids (CGA), however the level of CGA is reduced during the roasting process. The aim of this study is to investigate the effect of coffee roasting on vascular response. The investigators hypothesize that coffee roasted to a lesser extent will exert a favourable vascular response over more heavily roasted coffee due to the higher levels of CGA.

Official Title
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The Effect of High and Low Roasted Coffee on Vascular Response

Conditions
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Cardiovascular Disease

Intervention / Treatment
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* Dietary Supplement: Low roast coffee
* Dietary Supplement: High roast coffee
* Dietary Supplement: Control (Caffeine dissolved in water)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Male A signed consent form Age 19-35 years Body mass index - 18.5-30 kg/m2 Normal blood pressure at screening (< 150/90) Exclusion Criteria: Blood pressure > 150/90 mmHg Haemoglobin (anaemia marker) < 125 g/l Gamma GT (liver enzymes) > 80 IU/l Cholesterol > 6.5 mmol/l Had suffered a myocardial infarction or stroke in the previous 12 months Suffers from any reproductive disorder Suffers from any blood-clotting disorder Suffers from any metabolic disorders (e.g. diabetes or any other endocrine or liver diseases) Any dietary restrictions or on a weight reducing diet Drinking more than 21 units per week On any lipid-modifying medication On any blood pressure lowering medication On any medication affecting blood clotting Planning on altering consumption of vitamin supplements/fish oil capsules during the course of the study Regular or vigorous exercise (3 times/week, 20 minutes each session) Smoking Vegetarians or vegans

Ages Eligible for Study
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Minimum Age: 19 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: High roast coffee<br>110mg caffeine with 108 mg chlorogenic acid at start of study | Dietary Supplement: Control (Caffeine dissolved in water)<br>* Caffeine dissolved in water<br>|
| Active Comparator: Low roast coffee<br>110 mg caffeine with 235 mg chlorogenic acid at start of the study | Dietary Supplement: Low roast coffee<br>* Instant coffee<br>|
| Placebo Comparator: Control<br>110 mg caffeine at start of study | Dietary Supplement: High roast coffee<br>* Instant coffee<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Vascular response measured by flow mediated dilatation (FMD) |  | Change from baseline to 2 hours |