Neural Correlates of Compulsivity

Study Overview
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Brief Summary
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This study aims to collect data from individuals with obsessive-compulsive disorder (OCD) and healthy controls in order to clarify how learning strategies are employed differently by individuals with compulsive psychopathology and healthy individuals. Behavioral and electroencephalogram (EEG) data will be collected during one experimental reinforcement learning tasks from participants diagnosed with OCD (n = 30) and healthy controls (n = 30). Computational modeling, an advanced data analytic approach that can directly link neural measures with behavior, will be used to quantify learning processes. These parameters then will be related to measures of neural events obtained using EEG, a neuroimaging method that has high temporal resolution, to test for evidence of neurocognitive alterations.

Detailed Description
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Learning and decisions making are thought to be directed by multiple parallel cognitive systems. These systems account for automatic, inflexible responding to stimuli, as well as more deliberate, effortful representations of relationships in an environment. It has long been suggested than an imbalance in these cognitive control systems explains the emergence of compulsivity, a trait in which behaviors persist despite adverse outcomes. Compulsivity is a characteristic of a number of psychological disorders, however, current theories of how abnormalities in cognitive systems involved in learning and decision making lead to the onset of these disorders remain incomplete.

Official Title
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Neural Correlates of Compulsivity

Conditions
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Obsessive-Compulsive Disorder

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Between 18-50 years of age English-speaking Capacity to provide informed consent Primary diagnosis of OCD with at least moderate severity Exclusion Criteria: Current or lifetime history of psychiatric disorders other than OCD that may increase the risk of participation History of any significant medical condition that may increase the risk of participation Alcohol or substance use disorder in the past year Exposure and response prevention for OCD within the last six weeks Currently taking psychotropic medication

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Individuals diagnosed with OCD<br>Individuals diagnosed with OCD | |
| Healthy controls<br>Individuals who have not been diagnosed with any psychiatric disorders | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Neural Activity | EEG will be recorded while participants complete computerized reinforcement learning tasks at one study visit | One-time study visit | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Compulsivity, Obsessive-Compulsive Disorder, Exposure and Response Prevention, Electroencephalogram