Cassia Cinnamon for Glucose Uptake in Young Women

Study Overview
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Brief Summary
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The purpose of this study was to compare the acute effects of 5g of Cassia cinnamon, 50 minutes of endurance exercise performed at 70% of the heart rate reserve (correlated to VO2max), and 5g of cellulose placebo on blood glucose, serum insulin and insulin sensitivity following an oral glucose tolerance test 3 hours after administration of each intervention.

Official Title
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Cassia Cinnamon and Acute Endurance Exercise for the Enhancement of Glucose Uptake in Healthy Young Women

Conditions
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Prediabetes, Insulin Resistance, Impaired Glucose Tolerance

Intervention / Treatment
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* Dietary Supplement: Cassia cinnamon
* Procedure: 50 minutes exercise
* Dietary Supplement: Cellulose Powder


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Sedentary BMI: 27-45 DXA body fat % greater than 30% 18-30 years of age Healthy From the Baylor University campus and surrounding community Regular sleep habits Exclusion Criteria: Not regular users of any species of cinnamon Not diagnosed with any metabolic disorder or chronic medical condition Not taking prescription medications for 2 months before the study Not taking ergogenic aids for 2 months before the study Not taking oral contraceptives for 2 months before the study No IUD placed for 2 months before the study

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 30 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 5g Cassia cinnamon<br>Experimental treatment group | Dietary Supplement: Cassia cinnamon<br>* 5g encapsulated ground bark administered once in experimental session<br>* Other names: Brand: Nature's Bounty;|
| Active Comparator: 50 minutes endurnace exercise<br>Endurance exercise treatment known to influence blood glucose | Procedure: 50 minutes exercise<br>* 50 minutes treadmill endurance exercise at 70% of the heart rate reserve (correlated to VO2max)<br>|
| Placebo Comparator: 5g Cellulose<br>Placebo equivalent in weight and appearance to experimental treatment | Dietary Supplement: Cellulose Powder<br>* 5g encapsulated powder administered during placebo experimental session<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood Glucose |  | Baseline, 0, 30, 60, 90 and 120 minutes following OGTT | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Serum Insulin |  | Baseline, 0, 30, 60, 90 and 120 minutes following OGTT | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cassia, Cinnamon, Blood Glucose, Endurance exercise, Acute exercise, Overweight, Obesity, Women