The Performance of Renal Doppler Ultrasound in Predicting Outcome of Dialysis Weaning

Study Overview
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Brief Summary
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Acute kidney injury (AKI) is a frequent problem in the intensive care unit (ICU) affecting more than 50 % of patients. AKI is associated with several adverse outcomes, including increased mortality and increased length of ICU- and hospital stay, in particular in patients requiring Renal Replacement Therapy (RRT). Choosing the optimal time for attempting liberation from RRT is still unclear. With this study, we will describe the ability of renal ultrasound in predicting the outcome of dialysis weaning.

Official Title
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The Performance of Renal Doppler Ultrasound in Predicting Outcome of Dialysis Weaning

Conditions
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Acute Kidney Injury, Acute Kidney Failure Stage 3

Intervention / Treatment
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* Other: Dialysis weaning


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All patients ≥ 18 years admitted to the ICU, Aarhus University Hospital who are treated with dialysis as continuous renal placement therapy (CRRT) and planned to undergo dialysis weaning Exclusion Criteria: Insufficient ultrasonographic imaging of the kidneys Known morphological kidney disease Previous need of chronic RRT Prior participation in the study Need of extracorporeal membrane oxygenation (ECMO) or other heart assist device

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| ICU patients<br>Patients who are treated with dialysis as CRRT and planned to undergo dialysis weaning. | Other: Dialysis weaning<br>* Dialysis weaning as planned by the attending ICU-physician.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Dialysis weaning | If discontinuation of Dialysis is successful or not. Successful dialysis weaning is defined as no renal replacement therapy (RRT) required within the first 7 days after stopping continuous renal replacement therapy (CRRT) and non-successful weaning as the need for RRT within the first 7 days. | 7 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Renal Doppler arterial Resistive Index (RI) | Measured in the interlobar vessels | Measured at the beginning of weaning and after 6 hours. | 
| Renal Doppler Renal Venous Stasis Index (RVSI) | Measured in the interlobar vessels | Measured at the beginning of weaning and after 6 hours. | 
| Renal Doppler Venous Impedance Index (VII) | Measured in the interlobar vessels | Measured at the beginning of weaning and after 6 hours. | 
| Portal vein Doppler Pulsatility Fraction PF) | Measured in the interlobar vessels | Measured at the beginning of weaning and after 6 hours. | 
| Urine Output |  | 4 days | 
| Urine Creatinine Clearance |  | 4 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Ultrasound, Renal Replacement Therapy, Dialysis, Renal Doppler Ultrasound