Non-invasive Prediction of Esophageal Varices in Liver Cirrhosis: A Multicenter Observational Study

Study Overview
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Brief Summary
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Esophageal variceal bleeding is one of the most lethal complications of liver cirrhosis. In the early stage of liver cirrhosis, the prediction of esophageal varices is very important for guiding the clinical decision making of primary prophylaxis of variceal bleeding.

Detailed Description
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Esophageal variceal bleeding is one of the most lethal complications of liver cirrhosis. In the early stage of liver cirrhosis, the prediction of esophageal varices is very important for guiding the clinical decision making of primary prophylaxis of variceal bleeding. The investigators' recent systematic review evaluated the diagnostic accuracy of APRI, AAR, FIB-4, FI, King, Lok, Forns, and FibroIndex scores in predicting the presence of esophageal varices in liver cirrhosis. However, their diagnostic accuracy was low to moderate. Further study is warranted to establish a reliable score to predict the presence of high-risk esophageal varice in liver cirrhosis.

Official Title
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Non-invasive Prediction of Esophageal Varices in Liver Cirrhosis: A Multicenter Observational Study

Conditions
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Liver Cirrhosis, Esophageal and Gastric Varices

Intervention / Treatment
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* Procedure: Endoscopy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: A diagnosis of liver cirrhosis. Age and sex are not limited. Etiology of liver cirrhosis is not limited. Routine laboratory data. Upper gastrointestinal endoscopy. Exclusion Criteria: Non-cirrhotic portal hypertension. Malignancy. Absent laboratory data. A previous diagnosis of esophageal varices. A previous history of variceal bleeding.
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with esophageal varices<br>Esophageal varices were confirmed by endoscopy. They were divided into any grade and high-risk varices. | Procedure: Endoscopy<br>* Upper gastrointestinal endoscopy to evaluate the presence of any grade varices and high-risk varices.<br>|
| Patients without esophageal varices<br>Patients without esophageal varices were divided into patients without any grade or high-risk varices. | Procedure: Endoscopy<br>* Upper gastrointestinal endoscopy to evaluate the presence of any grade varices and high-risk varices.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation of biochemical data with esophageal varices in liver cirrhosis | The investigators firstly calculated the significant factors associated with the presence of esophageal varices, and then developed a score to predict the presence of esophageal varices in liver cirrhosis. | 18 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Liver cirrhosis, Esophageal and Gastric Varices, Endoscopy