Comparison of the Use of Energy Substrates and Hormonal Regulation of Blood Sugar During Exercise of Increasing Intensity Between Children With Type 1 Diabetes and Non-diabetic Control Children.

Study Overview
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Brief Summary
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The type 1 diabetes is a common chronic disease characterised by the stop of production of insulin by the pancreas. A lot of factors modify blood glucose. The objective is to study the effect of type 1 diabetes on the use of energy substrates (fats and carbohydrates) during exercise of increasing intensity by a comparison with non-diabetic controls children.

Detailed Description
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The type 1 diabetes is a common chronic disease characterised by the stop of production of insulin by the pancreas. A lot of factors modify blood glucose. The objective is to study the effect of type 1 diabetes on the use of energy substrates (fats and carbohydrates) during exercise of increasing intensity by a comparison with non-diabetic controls children.

Official Title
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Comparison of the Use of Energy Substrates and Hormonal Regulation of Blood Sugar During Exercise of Increasing Intensity Between Children With Type 1 Diabetes and Non-diabetic Control Children.

Conditions
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Type 1 Diabetes

Intervention / Treatment
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* Procedure: controlled physical activity


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Children between 6 and 12 years Tanner stage <T2 Type 1 diabetes for more than 1 year for infants with type 1 diabetes Exclusion Criteria: Tanner stage > ou = T2 Obesity Hormonal disease Disease who prevent doing exercise

Ages Eligible for Study
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Minimum Age: 6 Years
Maximum Age: 12 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: type 1 diabetes<br>Comparison between infants with type 1 diabetes and infants without type 1 diabetes during exercise : | Procedure: controlled physical activity<br>* Comparison between infants with type 1 diabetes and infants without type 1 diabetes during exercise :<br>|
| Active Comparator: without type 1 diabetes<br>Comparison between infants with type 1 diabetes and infants without type 1 diabetes during exercise : | Procedure: controlled physical activity<br>* Comparison between infants with type 1 diabetes and infants without type 1 diabetes during exercise :<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of substrate utilization between infants with type 1 diabetes and infants without type 1 diabetes during exercise | Measurements will be carried out by indirect calorimetry and the relationship between CO2 et O2 (Metamax) | at day 1 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| hormonal regulation of blood glucose | insulin, glucagon, adrenaline, cortisol and growth hormone will be metered according to their half life until 2 hours after physical activity (T12, T20, T40, T60, T120) | at day 1 | 
| lipoxmax : the intensity for wich lipid oxydation is maximum will be carried out by indirect calorimetry | during exercise | at day 1 | 
| Comparison between infants during 10 days before and 4 days after exercise of blood glucose modification | Comparison of curves of interstitial blood glucose measured with Freestyle® | 10 days before and 4 days after exercise of blood glucose modification | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Physical activity, Type 1 diabetes, Control, Substrate utilization, Hormonal regulation