Prevalence of Pulmonary Embolism in Patients With Dyspnea on Exertion (PEDIS)

Study Overview
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Brief Summary
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PEDIS Study is an observational, cross-sectional, multicenter Italian study conducted in a consecutive series of patients who refer to the Emergency Departments (either spontaneously or sent by their attending physicians) for the recent (less than one months) development of exertional dyspnea. The general aim of the study is to assess the prevalence of PE in the overall population referring to the Emergency Departments without potential explanations for dyspnea

Detailed Description
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PEDIS Study is an observational, cross-sectional, multicenter and no Profit Study. 600 consecutive patients referring to the Emergency Departments of the participating centers because they have developed one or more episodes of exertional dyspnea since less than one month will be enrolled. All eligible patients will be interviewed and examined by trained study physicians. The presence of already known potential explanations for the dyspnea will be assessed. In addition, symptoms of the lower extremities will be elicited, as well as the presence of risk factors for venous thromboembolism (VTE). The presence or absence of pulmonary embolism will be assessed with the use of a validated algorithm based on pre-test clinical probability and D-dimer result. In patients in whom the pre-test clinical probability is low and the D-dimer result is negative, no further testing will be done, and PE will be considered excluded. In patients with high clinical probability, positive D-dimer result, or both, computed tomography (CT) pulmonary angiography will be performed The primary study objective is to evaluate Prevalence of PE in the overall population

Official Title
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Prevalence of Pulmonary Embolism (PE) Among Patients Referred to Emergency Departments for Dyspnea on Exertion

Conditions
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Pulmonary Embolism

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age older than 18 and younger than 75 Recent (less than one month) development of exertional dyspnea Able to provide informed consent Exclusion Criteria: Anticoagulation required for other indications Contraindication to CT angiography (allergy to the contrast dye, severe renal failure [creatinine clearance < 30 ml/min]) Involvement in simultaneous clinical trials Unable to provide their written informed consent

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prevalence of PE in the overall population | Prevalence of Pulmonary Embolism in patient with high pre-test clinical probability and/or positive D-dimer without potential explanations for the dyspnea who underwent computed tomography pulmonary angiography | From the first day of enrollment up to 104 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Dyspnea, Pulmonary embolism