Combination Chemotherapy in Treating Women With Stage III Breast Cancer

Study Overview
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Brief Summary
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RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. PURPOSE: Randomized phase III trial to compare cyclophosphamide, doxorubicin, and fluorouracil with cyclophosphamide, methotrexate, and fluorouracil in treating women with stage III breast cancer.

Detailed Description
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OBJECTIVES: Compare the response in women with stage III breast cancer treated with neoadjuvant fluorouracil, doxorubicin, and cyclophosphamide (FAC) vs cyclophosphamide, methotrexate, and fluorouracil (CMF). Compare the rates of conservative surgical resectability and locoregional control in patients treated with these neoadjuvant therapy regimens. Compare the disease-free and overall survival of patients treated with these regimens. Compare the toxic effects of these regimens in these patients. Compare the compliance of patients treated with these regimens. Assess the cosmetic results in patients treated with conservative surgery. Compare the quality of life of patients treated with these regimens. OUTLINE: This is a randomized, multicenter study. Patients are stratified according to participating center. Arm I: Patients receive fluorouracil (5-FU) IV on days 1 and 8 and doxorubicin IV and cyclophosphamide (CTX) IV on day 1 (FAC). Treatment continues every 3 weeks for 3 courses in the absence of disease progression. Arm II: Patients receive CTX IV, methotrexate IV, and 5-FU IV on days 1 and 8 (CMF). Treatment continues every 4 weeks for 3 courses in the absence of disease progression. Patients on both arms with resectable disease after the third course of chemotherapy undergo quadrantectomy with axillary node dissection (preferred) or modified radical mastectomy, followed by 6 additional courses of chemotherapy on the arm to which they were randomized initially. Those patients without distant metastasis undergo locoregional radiotherapy beginning concurrently with the initiation of postoperative chemotherapy. Patients on both arms with unresectable disease after the initial 3 courses of chemotherapy undergo locoregional radiotherapy and then surgical resection (if feasible). Quality of life is assessed at baseline and then monthly thereafter. Patients are followed every 3-4 months for 2 years, every 4-6 months for 3 years, and then annually thereafter. PROJECTED ACCRUAL: Not specified

Official Title
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MULTIMODALITY TREATMENT STRATEGY FOR STAGE III BREAST CANCER

Conditions
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Breast Cancer

Intervention / Treatment
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* Drug: CAF regimen
* Drug: CMF regimen
* Drug: cyclophosphamide
* Drug: doxorubicin hydrochloride
* Drug: fluorouracil
* Drug: methotrexate
* Procedure: adjuvant therapy
* Procedure: conventional surgery
* Procedure: neoadjuvant therapy
* Radiation: radiation therapy


Participation Criteria
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Eligibility Criteria
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DISEASE CHARACTERISTICS: Histologically confirmed stage III breast cancer Measurable disease No inflammatory breast cancer No synchronous bilateral breast cancer Hormone receptor status: Not specified PATIENT CHARACTERISTICS: Age: 21 to 75 Sex: Female Menopausal status: Not specified Performance status: ECOG 0-1 OR Zubrod 0-1 Life expectancy: More than 12 weeks Hematopoietic: WBC greater than 4,000/mm^3 Platelet count greater than 100,000/mm^3 Hepatic: Bilirubin less than 1.25 times upper limit of normal (ULN) AST less than 1.25 times ULN Renal: Creatinine clearance greater than 70 mL/min Cardiovascular: No angina pectoris No significant arrhythmia requiring therapy No bilateral bundle branch block No congestive heart failure No myocardial infarction Other: No medical or psychiatric disease that would preclude study therapy No other malignancy except adequately treated nonmelanomatous skin cancer or carcinoma in situ of the cervix Not pregnant PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: Not specified Endocrine therapy: Not specified Radiotherapy: No prior radiotherapy Surgery: No prior surgery except incisional biopsy or fine-needle aspiration Other: No prior systemic therapy No concurrent caffeine or alcohol

Ages Eligible for Study
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Minimum Age: 21 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: CAF regimen|nan|
|Drug: CMF regimen|nan|
|Drug: cyclophosphamide|nan|
|Drug: doxorubicin hydrochloride|nan|
|Drug: fluorouracil|nan|
|Drug: methotrexate|nan|
|Procedure: adjuvant therapy|nan|
|Procedure: conventional surgery|nan|
|Procedure: neoadjuvant therapy|nan|
|Radiation: radiation therapy|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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stage IIIA breast cancer, stage IIIB breast cancer, stage IIIC breast cancer