Effect of Exercise Training on Angiogenesis and Cachexia in Lung Cancer Patients

Study Overview
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Brief Summary
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Cancer is one of the leading health issues in this country and worldwide. Angiogenesis is an essential process for tumoral growth and metastasis. This process is dependent on the balance between angiogenic factors and antiangiogenic factors. Muscle wasting has been associated with myostatin overexpression in cancer. Exercise training can depress tumor growth and suppress myostatin expression, and enhance skeletal muscle angiogenesis in healthy people and some animal studies. The purpose of this study is mainly to investigate the effects of exercise training on circulating VEGF-A muscle growth and function Myostatin

Official Title
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Effect of Exercise Training on Angiogenesis and Cachexia in Lung Cancer Patients

Conditions
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Non-small-cell Lung Cancer

Intervention / Treatment
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* Behavioral: Exercise training
* Other: Usual care


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 40-75 years Advanced NSCLC Eastern Cooperative Oncology Group performance status of 0 or 1 Targeted therapy for at least 8 weeks Stable condition Exclusion Criteria: Severe metastasis, cardiopulmonary or musculoskeletal conditions may affect participation in exercise Do not understand the verbal or written instructions

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Exercise training<br>Subjects in exercise group will undergo individualized high aerobic interval training on treadmill for 30 minutes under the supervision of an experienced physical therapist 3 times a week and home exercise twice a week with accelerometer. | Behavioral: Exercise training<br>* Subjects in exercise group will undergo individualized high aerobic interval training on treadmill for 30 minutes under the supervision of an experienced physical therapist 3 times a week and home exercise twice a week with accelerometer.<br>* Other names: High intensity interval aerobic training;|
| Active Comparator: Control group<br>Subjects in control group will not undergo individualized high aerobic interval training on treadmill. They will receive usual care as normally does in hospital. | Other: Usual care<br>* Subjects in control group will not undergo individualized high aerobic interval training on treadmill. They will receive usual care as normally does in hospital.<br>* Other names: Non-exercise or patient education;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Exercise capacity | Maximal oxygen consumption with Vmax229 Vastus lateral muscle oxygenation with NIRS | 8 weeks after the start of the intervention | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Imaging of muscle | Measured by MRS | 8 weeks and 16 weeks after the start of the intervention | 
| Analysis of venous blood sample | Analysis of circulating VEGF-A and myostatin | 8 weeks andd 16 weeks after the start of the intervention | 
| Quality of life | Measured by questionnaire | baseline, 8 weeks, 16 weeks | 
| Exercise capacity | Maximal oxygen consumption with Vmax229 Vastus lateral muscle oxygenation with NIRS | 16 weeks after the start of the intervention | 
| Muscle function | Isokinetic muscle strength and endurance with Biodex | 8 weeks and 16 weeks after the start of the intervention | 
| Physical activity | Measured with 7-day recall questionnaire | 8 weeks andd 16 weeks after the start of the intervention | 
| Dietary intake | Measured with 24-hour recall questionnaire | 8 weeks andd 16 weeks after the start of the intervention | 
| Body composition | Body mass index calculated with body weight and height % body fat abd free-fat mass with BIA | 8 weeks andd 16 weeks after the start of the intervention | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Tumor, Angiogenesis, Exercise training, VEGF, Myostatin