Long Term Effect of Splenectomy on Metabolism

Study Overview
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Brief Summary
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Metabolic status of patients who had gone through trauma splenectomy between July 2008 and July 2013 were compared to patients who had gone through bowel resection due to obstruction in the same period of time. all patients were followed up for 5-10 years.

Detailed Description
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A list was made of patients who had gone through trauma splenectomy or bowel resection due to bowel obstruction in our center between July 2008 and July 2013. Patients were divided into two groups: trauma splenectomy (exposed group) and bowel resection (unexposed group). All patients were followed up for 5-10 years. Of the 243 splenectomized patients, 90 patients who met our study criteria were willing to participate. Of 152 patients with bowel resection, 64 were willing to participate. Records of patients at the time of surgery were retrieved from hospital archive of patients' records. Patients were invited to an office meeting for assessment of blood pressure, BMI and a general physical examination and history taking. An appointment was made for drawing blood samples for measurement of lipid profile, Hb A1C and fasting blood sugar. Exclusion criteria: 1. Disturbed lipid profile at the time of surgery, 2. Disturbed blood glucose levels at the time of surgery, 3. History of high blood pressure prior to surgery, 4. Use of any hyperglycemogenic agent during the follow up period, 5. BMI>= 25 at the time of surgery, 6. History of diseases potentially affecting blood glucose, e.g. hyperthyroidism, Cushing syndrome, 7. Accidental pancreatic damage during surgery, 8. Resection of >10 cm of small bowel and 9. History of malignancy or radiotherapy (criteria 8 and 9 were specific to unexposed group).

Official Title
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Long-term Effect of Splenectomy on Metabolism, a Retrospective Cohort Study

Conditions
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Trauma Splenic

Intervention / Treatment
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* Diagnostic Test: Blood sample


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: trauma splenectomy or bowel resection due to obstruction between July 2008 and July 2013 Exclusion Criteria: disturbed lipid profile at the time of surgery disturbed blood glucose at the time of surgery history of high blood pressure at the time of surgery use of any hyperglcemogenic agent during the follow up BMI>= 25 at the time of surgery history of diseases that can affect blood glucose levels accidental pancreatic damage during surgery resection of > 10 cm of small bowel (for bowel resection group) history of malignancy or radiotherapy (for bowel resection group)
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Trauma splenectomized<br>Patients who had gone through trauma splenectomy. BMI, lipid profile, blood pressure and glucose tolerance of patients were assessed. Hb A1C and lipid profile were assessed through blood sampling. | Diagnostic Test: Blood sample<br>* Blood sample for Hb A1C and lipid profile, blood pressure and BMI<br>* Other names: BMI and blood pressure measurement;|
| Bowel resection<br>Patients who had gone through bowel resection due to obstruction. BMI, lipid profile, blood pressure and glucose tolerance of patients were assessed. Hb A1C and lipid profile were assessed through blood sampling. | Diagnostic Test: Blood sample<br>* Blood sample for Hb A1C and lipid profile, blood pressure and BMI<br>* Other names: BMI and blood pressure measurement;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Glucose tolerance | Glucose tolerance was assessed by measuring the Hb A1C of the patients in both groups. | July 2008- July 2013 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Splenectomy, metabolism, diabetes, stem cells, trauma surgery