Linking Optic Nerve MRI and the Retinal Axonal Loss After Optic Neuritis

Study Overview
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Brief Summary
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This study evaluates the length of optic nerve lesion on 3D-DIR sequence as an imaging biomarker predictive of retinal axonal loss and visual disability, 12 months after the occurence of a first clinical episode of optic neuritis.

Detailed Description
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Neurologists and Neuro-Ophthalmologists are in need for reliable and robust imaging biomarkers enabling to predict retinal axonal loss and visual disability after clinical episode of optic neuritis (ON). Length of optic nerve lesion measured on MRI may be one of them. The aim of our study is to measure the association between the extent of inflammatory demyelinating process on optic nerve at the acute of ON and the retinal degenerative process following optic nerve injury. The investigators planned to include 50 patients suffering from a recent clinical episode of ON. Extent of demyelinating inflammatory process will be assessed by the length of optic nerve double inversion recovery (DIR) hypersignal at the acute phase of ON. The axonal degenerative process following optic nerve demyelinating injury will be assessed by retinal atrophy measured on optical coherence tomography at 12 months after ON, by visual disability measured on low vision contrast acuity scale and by microstructural quality analysis of optic nerve measured on diffusion tensor imaging sequence of the optic nerve.

Official Title
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Linking Optic Nerve Lesion Length at MRI and the Retinal Axonal Loss at 12 Months From a Clinical Episode of Optic Neuritis

Conditions
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Optic Neuritis

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patient suffering from an acute clinical episode of optic neuritis (ON) confirmed by neurophthalmological examination < 2 months between start of acute episode of ON and inclusion Exclusion Criteria: past history of homolateral episode of ON retinal diseases diabeta mellitus pregnancy

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Severity of retinal axonal loss around papilla after a clinical episode of optic neuritis | peripapillary RNFL thickness decrease | 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Severity of retinal axonal loss within macula after a clinical episode of optic neuritis | macular volume decrease | 12 months | 
| Severity of visual disability after a clinical episode of optic neuritis | monocular low contrast (2.5%) vision | 12 months | 
| Severity of microstructural architecture of optic nerve after a clinical episode of optic neuritis | fractional anisotropy | 12 months | 
| Progression of optic nerve lesion length | lesion length in mm measured on 3D-double inversion recovery sequence | 12 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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optic neuritis, DIR, visual disability, CIS, multiple sclerosis, NMOSD