Safe Drinking Water For Households With Infants Born to HIV-Positive Mothers Pilot Study

Study Overview
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Brief Summary
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The purpose of this study is to assess whether children under 2 years and other members of households in which HIV-positive mothers are providing replacement and complementary feeding would potentially benefit from the use of a filter designed to eliminate microbial pathogens from drinking water at the household level.

Detailed Description
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Contaminated drinking water is a leading cause of morbidity and mortality in low-income settings. Safe drinking water is of particular concern for HIV-positive mothers since many HIV-infected Zambian women choose replacement feeding and early cessation of breastfeeding of infants to minimize the risk of transmission of the virus. This study builds upon preliminary baseline research which determined that HIV-positive mothers would potentially benefit from an intervention that encourages HIV-positive mothers to treat their water at the household level.

Official Title
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Safe Drinking Water For Households With Infants Born to HIV-Positive Mothers in Zambia: Piloting a Household Water Treatment Intervention

Conditions
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Diarrhea, HIV Infection

Intervention / Treatment
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* Device: LifeStraw Family


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Known HIV-status based on clinical testing Have a child between 6-12 months at the initiation of the study Within the catchment area of Kasisi or Ngwerere health clinics, Chongwe district, Lusaka Exclusion Criteria: Lived in the catchment area less than one year or planning to move
Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Control<br> | |
| Active Comparator: LifeStraw Family<br> | Device: LifeStraw Family<br>* LifeStraw Family is a household water treatment technology that will be implemented in the household to improve drinking water quality<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Use of LifeStraw Family for children under 2 and all household members | Use, acceptability, and longevity of LifeStraw Family will be assessed for replacement and complementary feeds for children under 2 and for drinking water for all members of the household | One year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Microbiological performance of LifeStraw Family | Microbiological performance of LifeStraw Family, measured in terms of thermotolerant coliforms (TTC), a well-established WHO indicator organism for faecal contamination | One year | 
| Impact of LifeStraw Family on longitudinal prevalence of diarrhea | Impact of the intervention on longitudinal prevalence of diarrhoea among infants under 2 years and all household members, measured both as reported by the primary caretaker of the child and by their weight-for-age z-score (WAZ) as a proxy for diarrhoea | One year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Diarrhea, Water, Household Water Treatment, HIV, Infant Health