Study of Microbiological Diversity in Exhaled Air in COPD and Free of COPD

Study Overview
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Brief Summary
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COPD and non-COPD patients will be included in the study after collection of their non-objection. The exhalation will be collected to study the microbiological diversity of human exhalations. a second collection for the year +1 will be made, at the same time (between October and March).

Detailed Description
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The subjects will be recruited during a medical visit in the Departments of Pneumology and Occupational and Environmental Pathologies. After information and inclusion of the subject in the study, a collection of clinical data, the state of health and the smoking status of the subject will be carried out by the clinical study technician. A collection of the exhalation will also be carried out by the clinical study technician. Several groups of subjects will be formed according to pathologies (COPD versus non-COPD), age and smoking status

Official Title
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Study of Microbiological Diversity in Exhaled Air in Adult Subjects With Chronic Obstructive Pulmonary Disease (COPD) and Subjects Free of COPD

Conditions
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Chronic Obstructive Pulmonary Disease

Intervention / Treatment
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* Other: collection of human exhalation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: For COPD: Patients with chronic obstructive pulmonary disease Age: over 18 For non-COPD Absence of chronic obstructive pulmonary disease Age: between 18 and 30 years old and between 45 and 70 years old Exclusion Criteria: Taking certain medications in the month preceding the sample (antibiotics, systemic corticosteroids, immunosuppressants) Person under guardianship or curatorship Pregnant or breastfeeding women Person unable to express his/her opposition, person deprived of liberty Existence of a chronic infectious pulmonary pathology such as (dilation of the bronchi, cystic fibrosis)

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Chronic Obstructive Pulmonary Disease (COPD)<br>Patients with chronic obstructive pulmonary disease will be recruited from the pulmonology or occupational pathology department. They are either active smokers or ex-smokers. They are over 18 years old | Other: collection of human exhalation<br>* the collection of the exhalation will be carried out with a non-invasive device manufactured by a Chinese company. The collection of exhalation consists of the subject inhaling through the nose and exhaling gently through the mouth through a plastic straw for a time set at 5 min in the device<br>|
| NO-Chronic Obstructive Pulmonary Disease<br>The no-COPD are controls followed in chi créteil for another pathology. They are between 18 and 30 years old and 45 and 70 years old. They are either: Ex-smoker Active smoker Non-smoker | Other: collection of human exhalation<br>* the collection of the exhalation will be carried out with a non-invasive device manufactured by a Chinese company. The collection of exhalation consists of the subject inhaling through the nose and exhaling gently through the mouth through a plastic straw for a time set at 5 min in the device<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number and dominant bacterial species in human exhalations of COPD subjects and non-COPD subjects | number and bacterial species | Baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number and dominant bacterial species in human exhalations according to smoking status | number and bacterial species | Baseline | 
| Number and dominant bacterial species in human exhalations according to age | number and bacterial species | Baseline | 
| Number and dominant bacterial species in human exhalations for patients returning for consultation 1 year apart during the winter season | number and bacterial species | 1 year |