Unveiling Preclinical Idiopathic Macular Hole Formation

Study Overview
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Brief Summary
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A macular hole is a rupture in the macula. In terms of pathogenesis, as much as 80% are idiopathic (Idiopathic Macular Hole, IMH). The normal incidence of this condition is about 0.17%; however, there is a 10-29% chance of development of a macular hole in the fellow eye of patients suffering from unilateral macular hole. Our hypothesis is that embedded in the topography of the retina is information that can allow for discrimination between healthy eyes and eyes with an increased risk of developing IMH. As such, our work aims to develop a system that allows the automatic identification of these eyes.

Detailed Description
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A macular hole is a rupture in the macula, the central portion of the retina, responsible for sharp, central vision and hence indispensable for most tasks. In terms of pathogenesis, even though some can be related to trauma, as much as 80% are idiopathic (Idiopathic Macular Hole, IMH). It is theorized that antero-posterior and tangential forces are behind this condition; however, no conclusions have been reached. While the normal incidence of this condition is about 0.17%, there is a 10-29% chance of developing a macular hole in the fellow eye of patients suffering from unilateral macular hole. Our working hypothesis is that embedded in the topography of the retina is information that can allow for discrimination between healthy eyes and eyes with an increased risk of developing IMH. As such, our study consists on the characterisation of the retinal topography of fellow eyes of patients with unilateral IMH but no other visible retinal pathologies, and of eyes from controls subjects in the same approximate age group. From these topographic maps we acquire a series of features (parameters), and using machine learning techniques create a system that separates eyes into one of the groups - healthy or at risk.

Official Title
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Unveiling Preclinical Idiopathic Macular Hole Formation

Conditions
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Idiopathic Macular Hole

Intervention / Treatment
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* Other: Optical Coherence Tomography Scan


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: normal OCT, with or without vitreous adhesion fellow group: unilateral idiopathic macular hole Exclusion Criteria: OCT with vitreous adhesion lamellar or pseudoholes inner retinal surface alterations myopia(>4D) glaucoma significative media opacity previous retina photocoagulation any type of intraocular surgery in the last 6 months intravitreal medication diabetes or neurodegenerative diseases macular hole secondary to trauma

Ages Eligible for Study
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Minimum Age: 45 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Fellow Eyes<br>Patients that suffer from unilateral idiopathic macular hole, and whose fellow eyes don't show any sign of retinal pathology. | Other: Optical Coherence Tomography Scan<br>* As an observational study, the only interventive action taken is the acquisition of a non-invasive volumetric image of the retina via optical coherence tomography (OCT).<br>|
| Controls<br>Healthy subjects age-matched to the other group, with no visible retinal pathologies. | Other: Optical Coherence Tomography Scan<br>* As an observational study, the only interventive action taken is the acquisition of a non-invasive volumetric image of the retina via optical coherence tomography (OCT).<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Macular Topography | When a patient that fits into the description of either the case or the control group comes in for a routine visit, a routine optical coherence tomography scan is performed. These scans are non-invasive and common in ophthalmological visits. | at 1 visit | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Idiopathic Macular Hole