Exercise Training Associated With Inspiratory Muscle Training in Heart Failure

Study Overview
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Brief Summary
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The investigators hypothesize that aerobic exercise training associated with respiratory muscle training will cause additional benefits compared to isolated exercise training or respiratory training in chronic heart failure patients.

Detailed Description
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The investigators hypothesize that aerobic exercise training associated with respiratory muscle training will cause additional benefits in the autonomic control and respiratory function compared to isolated exercise training or respiratory training in chronic heart failure patients.

Official Title
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Effects of Aerobic Exercise Training Associated With Inspiratory Muscle Training in Patients With Heart Failure

Conditions
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Heart Failure

Intervention / Treatment
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* Other: Exercise training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with systolic heart failure and New York Heart Association (NYHA) class II-III Left ventricular ejection fraction less than 40% Peak Oxygen Consumption less than 20 ml/Kg/min Exclusion Criteria: Chronic Obstructive Pulmonary Disease Neuromuscular, Orthopedic, Neurologic and Neoplastic Diseases Recent myocardial infarction or cardiac surgery (less than 6 months) Unstable angina pectoris Atrial Fibrillation Pacemakers users Actual Smoker Pregnant Changing medication or hospital admission

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Control Group<br>No exercise group (sedentary) | |
| Experimental: Aerobic Exercise Training<br>Group undergoing isolate aerobic exercise training 3 times/week, during 40 minutes, for 04 mouths | Other: Exercise training<br>* The heart failure patients are subjected to differents protocols of physical training<br>|
| Experimental: Inspiratory Muscle Training<br>Group undergoing isolate inspiratory muscle training 7 times/week, during 30 minutes, for 04 mouths | Other: Exercise training<br>* The heart failure patients are subjected to differents protocols of physical training<br>|
| Experimental: Aerobic+Inspiratory Muscle Training<br>Group undergoing aerobic exercise training (3 times/week during 40 minutes) associate inspiratory muscle training (7 times/week during 30 minutes) for 04 mounths | Other: Exercise training<br>* The heart failure patients are subjected to differents protocols of physical training<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Autonomic control | Exercise training associated with inspiratory muscle training will reduce sympathetic nerve activity. | 4 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Functional Capacity | Exercise training associated with inspiratory muscle training will improve peak oxygen consumption | 4 months | 
| Quality of life | Exercise training associated with inspiratory muscle training will improve quality of life | 4 months | 
| Blood inflammatory markers | Exercise training associated with inspiratory muscle training will reduces blood inflammatory markers | 4 months | 
| Muscular evaluation | Exercise training associated with inspiratory muscle training will increase skeletal muscle strength | 4 months | 
| Respiratoy muscle function | Exercise training associated with inspiratory muscle training will increase inspitarory muscle strength and endurance. | 4 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Heart Failure, Exercise and Physical Fitness