Pediatric Eye Care Investigated Team

Study Overview
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Brief Summary
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Use cohort research to analyze and compare eyes of healthy children and children with systemic diseases. Understand and analyze the incidence, characteristics and influencing factors of children's ocular surface diseases. Establish a multi-center children's eye data sharing platform to provide basic data support for the diagnosis and treatment of children's ocular surface diseases.

Detailed Description
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Use cohort research to analyze and compare eyes of healthy children and children with systemic diseases. Understand and analyze the incidence, characteristics and influencing factors of children's ocular surface diseases. Establish a multi-center children's eye data sharing platform to provide basic data support for the diagnosis and treatment of children's ocular surface diseases. All participants will be recruited from Zhongshan Ophthalmic Center, Sun Yat-sen University and Affiliated Foshan Maternity & Child Healthcare Hospital, Southern Medical University. Only children with written informed consent from their parents can participate in this study. Participants will be excluded for (1) age>18; (2) previous use of orthokeratology lenses or low-concentration atropine; (3) allergy to compound tropicamide eye drop; (4) any history of ocular surgery. All participants will undergo optometry and biometric measurements by a trained team. The axial length (AL), central corneal thickness (CCT), anterior corneal radii of curvature, anterior chamber depth (ACD), lens thickness (LT), the curvature power of the central flat meridian (K1) and the central steep meridian (K2), the ocular surface and fundus will be measured. All measurements will be taken in room light condition (1000 lux).

Official Title
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Constructing Children's Eye Data Sharing Platform in Multiple Centers and Multiple Disciplines

Conditions
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Eye Diseases, Ocular Surface Disease, Systemic Disease, Children

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 1. Age≤18 2. Cooperate with eye examination 3. Sign informed consent Exclusion Criteria: 1. Cannot cooperate with eye examination 2. The researcher believes that the patient is not suitable to participate in the study.

Ages Eligible for Study
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Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| children with systemic diseases<br>Systemic diseases such as Nephritic syndrome, and other systemic diseases that can affect the eyes. | |
| healthy children<br>The exclusion criteria for the subjects were eye diseases or other systemic diseases that can affect the quality or volume of tears or the secretion of tears. These included eyelid diseases: eyelid entropion, eyelid ectropion, ptosis, and palpebral dyskinesia; conjunctival diseases: pterygium and conjunctivitis; history of ocular surface chemical injury; history of eye surgery within 6 months or history of retinal laser photocoagulation; systemic diseases: Sjogren syndrome, Parkinson's disease, rheumatoid arthritis, Grave's disease, systemic lupus erythematosus, and others. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change of the non-invasive tear break-up time | change of the non-invasive tear break-up time in seconds | baseline, 24th months | 
| change of the lipid layer of tear film | change of the lipid layer of tear film in nanometers | baseline, 24th months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| vision | spherical equivalent in diopters | baseline, 6th months, 12th months, 18th months, 24th months | 
| intraocular pressure | the intraocular pressure in mm Hg | baseline, 6th months, 12th months, 18th months, 24th months | 
| Eye axis length | Eye axis length in millimeters | baseline, 6th months, 12th months, 18th months, 24th months | 
| Anterior chamber depth | Anterior chamber depth in millimeters | baseline, 6th months, 12th months, 18th months, 24th months | 
| central corneal thickness | central corneal thickness in millimeters | baseline, 6th months, 12th months, 18th months, 24th months | 
| Lens thickness | Anterior chamber depth in millimeters | baseline, 6th months, 12th months, 18th months, 24th months | 
| Retina thickness | retina thickness in millimeters | baseline, 6th months, 12th months, 18th months, 24th months | 
| choroid thickness | choroid thickness in millimeters | baseline, 6th months, 12th months, 18th months, 24th months | 
| Corneal curvature | Corneal curvature in diopters | baseline, 6th months, 12th months, 18th months, 24th months | 
| non-invasive tear break-up time | non-invasive tear break-up time in seconds | 6th months, 12th months, 18th months | 
| the lipid layer of the tear film | the lipid layer of the tear film in nanometers | 6th months, 12th months, 18th months |