An Eye Tracking Study of Affective Disorder Patients With Suicide Risk

Study Overview
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Brief Summary
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This research tries to investigate the validity and reliability of eye-tracking technologies by using different paradigms (eg. free-view, pro-saccade and anti-saccade) which served as a novel way of evaluating suicide risk among affective disorder patients including bipolar and unipolar depression. All the participants including health control will be assessed by clinical interviewing, self-report assessment, cognitive evaluation and eye-tracking task.

Official Title
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An Eye Tracking Study of Affective Disorder Patients With Suicide Risk

Conditions
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Major Depressive Disorder, Bipolar Disorder, Suicide

Intervention / Treatment
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* Behavioral: eye-tracking


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnostic and Statistical Manual,DSM-IV diagnosis of depression or Bipolar disorder BDI-II>20(Suicide and disorder control group); BDI-II<13，no history of depression(Health control) Informed consent suicide attempt in the past 6 months(suicide risk group) Exclusion Criteria: Current or past substance abuse, psychotic disorder,obsessive compulsive disorder , Post-Traumatic Stress Disorder, in the past 6 months History of epilepsy or head trauma Eye disorders History of electroconvulsive therapy in the past 4 weeks.

Ages Eligible for Study
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Minimum Age: 12 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Suicide Risk Group<br>patients with affective disorders(eg. bipolar disorder, major depression disorder) also have a history of suicide attempt in the past 6 months. | Behavioral: eye-tracking<br>* After completing a demographics form, theBeck Depression Inventory,Beck Anxiety Inventory,Barratt Impulsiveness Scale and Ruminative Response Scale-21, each participant has to go to the eye-tracking room and seats in a height adjustable chair and places their chin in a chin rest which was positioned to make sure all participants' eye are in the same location relative to the camera and the monitor. There are 18 trials and 2 filler trials in the free-view task, each of which contains 4 pictures on the same screen for 25 seconds. There is also a gap screen between each trial lasting for 2 seconds when participants were asked to fixate in the center of the screen. During the experiment, participants are instructed to watch the screen as naturally as possible, and the initial location of the fixation of each trial and the total dwell time of each emotional images(negative, happy, neutral and suicide-related)and the changes of the pupil size were recorded.<br>|
| Disorder Control Group<br>patients with affective disorders(eg. bipolar disorder, major depression disorder) and without suicide ideation or behavior. | Behavioral: eye-tracking<br>* After completing a demographics form, theBeck Depression Inventory,Beck Anxiety Inventory,Barratt Impulsiveness Scale and Ruminative Response Scale-21, each participant has to go to the eye-tracking room and seats in a height adjustable chair and places their chin in a chin rest which was positioned to make sure all participants' eye are in the same location relative to the camera and the monitor. There are 18 trials and 2 filler trials in the free-view task, each of which contains 4 pictures on the same screen for 25 seconds. There is also a gap screen between each trial lasting for 2 seconds when participants were asked to fixate in the center of the screen. During the experiment, participants are instructed to watch the screen as naturally as possible, and the initial location of the fixation of each trial and the total dwell time of each emotional images(negative, happy, neutral and suicide-related)and the changes of the pupil size were recorded.<br>|
| Healthy Control Group<br> | Behavioral: eye-tracking<br>* After completing a demographics form, theBeck Depression Inventory,Beck Anxiety Inventory,Barratt Impulsiveness Scale and Ruminative Response Scale-21, each participant has to go to the eye-tracking room and seats in a height adjustable chair and places their chin in a chin rest which was positioned to make sure all participants' eye are in the same location relative to the camera and the monitor. There are 18 trials and 2 filler trials in the free-view task, each of which contains 4 pictures on the same screen for 25 seconds. There is also a gap screen between each trial lasting for 2 seconds when participants were asked to fixate in the center of the screen. During the experiment, participants are instructed to watch the screen as naturally as possible, and the initial location of the fixation of each trial and the total dwell time of each emotional images(negative, happy, neutral and suicide-related)and the changes of the pupil size were recorded.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| eye movement performance during free-view task | The first fixated location and latency(msec)of eah trial, the total dwell time(msec) in each interest areas(IAs) during the whole trial to assess the attentional bias in the experiment. | 1 hour | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Scores in self-report assessment:Beck Depression Inventory | This scale is aimed to assess the clinical depressive symptom in the recent 7 days. | 5 minutes | 
| Scores in self-report assessment:Beck Anxiety Inventory | This scale is aimed to assess the clinical anxieous symptom in the recent 7 days | 5 minutes | 
| Scores in self-report assessment:Barratt Impulsiveness Scale | This scale is aimed to assess participant's impulsive trait. | 5 minutes | 
| Scores in self-report assessment:Ruminative Response Scale | This scale is aimed to assess participant's ruminative thinking process. | 5 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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eye-tracking, eye movement, saccade