Investigating Event-Related Potentials and Eye-Tracking Measures in Hockey Players

Study Overview
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Brief Summary
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Traumatic brain injury (TBI) is a health issue impacting athletes and no clinical treatment protocol, other than rest, is yet established. The efficacy of a treatment protocol relies on objective, physiological measures of brain function and ultimately a quantification of injury severity. The present study aims to assess neurophysiological markers of auditory and visual measures of brain function using the NeuroCatch Platform and eye-tracking technology, respectively. The current gold standard of TBI evaluation, including cognitive and balance assessments, will also be captured.

Official Title
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Assessing Neurophysiological Markers of Brain Function: Investigating Event-Related Potentials and Eye-Tracking Measures in Hockey Players

Conditions
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Healthy, Traumatic Brain Injury

Intervention / Treatment
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* Device: NeuroCatch Platform (NCP)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Any sex, 14-25 years old inclusively Attending the Creative Artists Agency LLC (CAA) hockey camp in July 2019 Able to understand the informed consent/assent form, study procedures and willing to participate in study NeuroCatch Platform-Specific Inclusion Criteria Able to remain seated and focused for 6 minutes Normal hearing capabilities Exclusion Criteria: • Unable to provide informed consent NeuroCatch Platform-Specific Exclusion Criteria Clinically documented hearing issues (e.g. tinnitus, in-ear hearing problems or punctured ear drum) In-ear hearing aid or cochlear implant, hearing device Implanted pacemaker or defibrillator Metal or plastic implants in skull Exposed to an investigational drug or device 30 days prior to start in this study, or concurrent or planned use of investigational drug or device during hockey camp (July 7th - 13th 2019) Not proficient in English Previous exposure to the NeuroCatch™ Platform audio sequences in the last 6 months History of seizures Allergy to rubbing alcohol or EEG gel Unhealthy scalp (apparent open wounds and/or bruised or weakened skin)

Ages Eligible for Study
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Minimum Age: 14 Years
Maximum Age: 25 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| hockey players<br>During each study visit, the participants will undergo the following procedures: NeuroCatch Platform (NCP) assessment (only if participant meets NCP-specific criteria) RightEye's eye-tracking battery Highmark Interactive's EQ application Cambridge Brain Science's neuropsychological tests | Device: NeuroCatch Platform (NCP)<br>* The NCP plays a proprietary 6-minute auditory stimulus sequence of tones and words that elicit involuntary evoked responses in the brain. Tone stimuli elicit N100 and P300 responses, and spoken word pairs elicit N400 responses. The NCP proprietary software identifies the latency and amplitude (timing and size) of three selected ERPs. Latency and amplitude values are reported as empirical (measured) values.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| ERP response size | amplitude in microvolts | 1 week | 
| ERP response timing | latency in milliseconds | 1 week | 
| Eye-tracking: target accuracy | distance in millimeters for each eye | 1 week | 
| Eye-tracking: speed | degrees per second | 1 week | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cognitive tests | Cognitive assessments will be captured using Cambridge Brain Sciences battery of neuropsychological tests (composite score) and Highmark Interactive's EQ app | 1 year | 
| Balance | Balance measured in seconds as captured by Highmark Interactive's EQ app | 1 week |