Safety and Efficacy Study of Glufosfamide in Patients With Recurrent Sensitive Small Cell Lung Carcinoma

Study Overview
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Brief Summary
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The primary objectives of this study are: To evaluate the efficacy of glufosfamide in subjects with extensive recurrent sensitive small cell lung cancer (SCLC) as measured by objective response rate To evaluate the safety of glufosfamide in subjects with extensive recurrent sensitive SCLC The secondary objectives are: To evaluate the efficacy of glufosfamide in subjects with extensive recurrent sensitive SCLC as measured by duration of response, progression-free survival and overall survival To evaluate the pharmacokinetics of glufosfamide and isophosphoramide mustard (IPM) The exploratory objectives of this trial are: To evaluate the effect of glufosfamide on lung cancer symptoms To evaluate the role of tumor cell glucose transporter expression on the efficacy of glufosfamide

Official Title
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An Open-Label, Phase 2 Study to Evaluate the Safety and Efficacy of Glufosfamide in the Treatment of Patients With Recurrent Sensitive Small Cell Lung Carcinoma

Conditions
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Carcinoma, Small Cell Lung

Intervention / Treatment
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* Drug: Glufosfamide


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: At least 18 years of age Ability to understand the purposes and risks of the study and has signed a written informed consent form approved by the investigator's IRB/IEC Documented extensive SCLC with progression occurring at least 60 days after completion of first-line therapy (sensitive disease) Measurable disease by RECIST criteria (at least one target lesion; no target lesion may have received radiotherapy within 6 weeks of study start) A minimum of 21 days between prior radiation therapy, immunotherapy, or other anti-tumor therapy and study entry Recovered from reversible toxicities of prior therapy Eastern Cooperative Oncology Group (ECOG) Performance Status score of 0, 1, or 2 Hemoglobin ≥ 9.0 g/dL, ANC ≥ 1,500/µL, platelets ≥ 100,000/µL Total bilirubin ≤ 1.5-fold ULN AST/ALT ≤ 2.5-fold ULN (≤ 5-fold ULN if liver metastases) Creatinine clearance ≥ 60 mL/min (calculated by Cockcroft-Gault formula) All women of childbearing potential and all men must agree to use effective means of contraception (surgical sterilization or the use of barrier contraception with either a condom or diaphragm in conjunction with spermicidal gel or an IUD) from entry into the study through 6 months after the last dose Exclusion Criteria: More than one previous chemotherapy regimen Concomitant or planned hormonal therapy, radiation therapy, biologic therapy, chemotherapy or other systemic antitumor therapy for SCLC other than protocol therapy Limited stage SCLC (defined as confined to one hemithorax including ipsilateral supraclavicular lymph nodes and excluding pleural effusion) Symptomatic brain metastases requiring corticosteroids Active clinically significant infection requiring antibiotics Known HIV positive or active hepatitis B or C Recent (one year) history or symptoms of cardiovascular disease (NYHA Class 2, 3, or 4), particularly coronary artery disease, arrhythmias or conduction defects with risk of cardiovascular instability, uncontrolled hypertension, clinically significant pericardial effusion, congestive heart failure, or stroke Other active malignancies (other than treated non-melanoma skin cancer or treated in situ cancer) within the past 5 years Major surgery within 28 days of the start of study treatment, without complete recovery Females who are pregnant or breast-feeding Participation in an investigational drug or device study within 28 days of the first day of dosing on this study Concomitant disease or condition that could interfere with the conduct of the study, or that, in the opinion of the investigator, could pose an unacceptable risk to the subject in this study. Unwillingness or inability to comply with the study protocol for any other reason

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Glufosfamide|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Recurrent Sensitive Small-Cell Lung Cancer