Engaging Practices and Communities in the Development of Interventions to Promote HPV Vaccine Uptake

Study Overview
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Brief Summary
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The overarching goal of this project is to implement Boot Camp Translation (BCT) methodology to translate the guidelines and evidence for human papillomavirus (HPV) vaccine into a practice and provider level intervention designed to improve its acceptability and uptake.

Detailed Description
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As a community engagement approach, Boot Camp Translation (BCT), is a 6-9-month iterative process that brings together multiple stakeholders, including patients, parents, and community members, to translate evidence-based guidelines and recommendations into locally relevant and meaningful messages, materials, and programs. Aim 1: Implement BCT in three geographically distinct Colorado communities to translate the current evidence for HPV vaccination into locally relevant interventions designed to increase vaccine uptake. Aim 2: Evaluate the impact of the BCT- designed intervention on practice-level HPV vaccination initiation rates. The long-term goal is to develop a replicable approach and low-cost method of increasing HPV vaccine uptake that is easily adaptable to different settings and sociodemographic contexts.

Official Title
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Engaging Practices and Communities in the Development of Interventions to Promote HPV Vaccine Uptake

Conditions
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Primary Prevention

Intervention / Treatment
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* Behavioral: Boot Camp Translation
* Other: Control


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All child patients who have received health supervision at participating practices during the 12 month prior to intervention and the 12 month following intervention implementation, who are ages 9-26 years, and whose parents have not requested removal from the Colorado Immunization Information System (CIIS) will be eligible for the assessment of practice immunization rates in the pre and post periods. Exclusion Criteria: No subjects will be excluded because of gender, ethnicity, or insurance status. Any child whose parents have requested removal from the immunization registry; any child with hypersensitivity to any component of one of the recommended vaccines; any child who has moved to a primary care provider other than one at the study clinics.

Ages Eligible for Study
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Minimum Age: 9 Years
Maximum Age: 26 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Boot Camp Translation<br>Intervention practices will undergo the Boot Camp Translation process. | Behavioral: Boot Camp Translation<br>* Practices in the intervention arm will participate in the Boot Camp Translation process, where BCT Community Advisory group members will come together to develop and implement practice relevant materials to promote adolescent vaccination.<br>|
| Active Comparator: Control<br>Control practice will behave as usual. | Other: Control<br>* No intervention. Practices will continue to behave as usual.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Initiation of HPV vaccination series, 9-17 | Percent of 9-17 year olds who have received >=1 dose of the HPV vaccine by September 29, 2021 | Up to 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Differences in initiation rates between intervention vs. control, 9-10 | Comparison of boys vs. girls who have received >1=dose of HPV vaccine by September 29, 2021 | 12 months | 
| Differences in initiation rates between intervention vs. control, 11-12 | Comparison of boys vs. girls who have received >1=dose of HPV vaccine by September 29, 2021 | 12 months | 
| Differences in initiation rates between intervention vs. control, 13-17 | Comparison of boys vs. girls who have received >1=dose of HPV vaccine by September 29, 2021 | 12 months | 
| Differences in initiation rates between intervention vs. control, 18-26 | Percent of 18-26 year olds who have received >=1 dose of the HPV vaccine by September 29, 2021 | 12 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Immunization, Boot Camp Translation, Adolescent, Human Papillomavirus, Vaccine