Early Vitrectomy for Endophthalmitis After Cataract Surgery

Study Overview
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Brief Summary
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Post-operative infectious endophthalmitis is devastating condition that causes a diffuse intraocular inflammation and may lead to blindness. Acute post-operative endophthalmitis usually presented within 6 weeks of intraocular procedure and diagnosis is confirmed by clinical examination and by the aid of B-scan ultrasonography.

Detailed Description
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There is no consensus regarding the timing of vitrectomy in cases with endophthalmitis after cataract surgery. The Endophthalmitis Vitrectomy Study concluded that vitrectomy should be preserved for cases with only light perception. The advances in posterior segment machines and small gauge cannulas decrease the incidence of intra-operative complications and encourage for early intervention in cases with endophthalmitis after primary cataract surgery.

Official Title
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Outcomes of Early Vitrectomy for Endophthalmitis After Cataract Surgery in Delta Population, Egypt, 2015-2020.

Conditions
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Endophthalmitis, Cataract, Vitreous Detachment, Retinal Detachment

Intervention / Treatment
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* Procedure: Early 23-gauge pars-plana vitrectomy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Acute onset endophthalmitis within 6 weeks after primary cataract surgeries. Patients had undergone early pars-plana vitrectomy within 48 hours of their confirmed diagnosis. Exclusion Criteria: Patients were diagnosed as endogenous or chronic endophthalmitis. Patients with a previous history of rupture globe surgery or trauma. Patients who didn't complete the follow up period.

Ages Eligible for Study
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Minimum Age: 3 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Endophthalmitis after primary cataract surgery.<br>Cases diagnosed as acute post-operative endophthalmitis after primary cataract surgery. | Procedure: Early 23-gauge pars-plana vitrectomy<br>* pars-plana vitrectomy for management of acute post-operative endophthalmitis.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Best-corrected visual acuity | Changes in visual acuity from baseline and after early vitrectomy operation. | Baseline and 3 months after intervention. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Other prognostic factors | Other factors that may influence the final visual outcome in cases with endophthalmitis as (intraocular tamponade, posterior vitreous detachment, systemic condition and virulence of causative organism) | Baseline and 3 months after intervention. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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endophthalmitis, cataract, vitrectomy, retinal detachment