Endometrial Scratching During Laproscopic Ovarian Drilling in Subfertile PCOS Women

Study Overview
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Brief Summary
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Laparoscopic Ovarian Drilling is a valid procedure for infertile anovulatory women with polycystic ovarian syndrome who failed to get pregnant or to ovulate with ovulation induction medications as clomiphene citrate or exogenous gonadotropins. The reasearchers supposed that endometrial curettage at time of laparoscopic ovarian drilling may boost fertility in these women.

Detailed Description
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Current literature suggests that endometrial biopsy may improve pregnancy rates in infertile women hence the investigators will examine whether this hypothesis will apply to infertile PCOS women undergoing laparoscopic ovarian drilling to overcome ovulatory disfunction or not.

Official Title
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Endometrial Scratching at Time of Laproscopic Ovarian Drilling in Women With Anovulatory Infertility Due to Polycystic Ovarian Syndrome (PCOS): Randomized Controlled Trial.

Conditions
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Infertility, Polycystic Ovarian Syndrome

Intervention / Treatment
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* Procedure: Endometrial Currettage


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: subfertile women with anovulatory infertility due to polycystic ovarian syndrome (PCOS). Women who failed to get pregnant after at least 6 months of ovulation induction cycles with clomiphene citrate or exogenous gonadotropins Patent Fallopian tubes as confirmed by hysterosalpingography Fertile semen parameters of the partneraccording to criteria of World Health Organization (WHO 2010). Exclusion Criteria: women with BMI >30, age < 18 years or > 39 years, women with ovarian cysts identified by transvaginal ultrasound male factor infertility Tubal factor infertility as suggested by hystrosalpingogram (HSG) Women with congenital malformations in the uterus as bicornuate or septate uterus as suggested by HSG.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 39 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Currettage<br>Endometrial Currettage (endometrial scrapping) will be performed at the time of laparoscopic ovarian drilling | Procedure: Endometrial Currettage<br>* Only Laparoscopic ovarian drilling without endometrial currettage will be performed<br>* Other names: Endometrial scraping;|
| No Intervention: Nothing<br>No endometrial curettage at time of Laparoscopic ovarian drilling | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| live birth rate per woman randomized |  | 15 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| pregnancy rate per woman randomised |  | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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infertility, PCOS, scratching, endometrial receptivity