Behavioral Addictions and Related NeuroCOgnitive Aspects

Study Overview
=================
Brief Summary
-----------------
Improving knowledge about behavioural addictions is a real public health issue. The etiopathogenic model of behavioural addictions is multifactorial, with various risk and vulnerability factors, involved in the initiation and maintenance of the disorders. Among these factors, neurocognitive alterations associated with behavioural addictions has recently aroused interest among researchers. To our knowledge, there is no work wich compared several behavioural addictions with each other on a neurocognitive level. Moreover, neurocognitive data concerning certain behavioural addictions (such as sexual addiction) is almost non-existent. However, understanding the neurocognitive profiles of these patients would allow the investigators, on the one hand, to reinforce the existing literature and improve our understanding of the global process of addiction, and on the other hand, to propose alternative approaches to its management, taking into account the neurocognitive difficulties of the patients. The investigators therefore propose to explore the neurocognitive alterations of patients suffering from several behavioural addiction (sexual addiction, excessive use of video games and eating disorders with bulimia episodes), by comparing them with each other, to matched healthy control groups and to a recognized behavioural addiction (gambling disorder; data from the BANCO study - NCT03202290).

Official Title
-----------------
Study BANCO2: Behavioral Addictions and Related NeuroCOgnitive Aspects : Monocentric, Prospective, Controlled, Open-label Study Conducted With a Sample of Patients With Behavioural Addiction

Conditions
-----------------
Behavioral Addiction

Intervention / Treatment
-----------------
* Behavioral: Cognitive and clinical assessment


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria for all participants: More than 15 years and 3 months old Mastering the French language Social Security Affiliates Having given consent Correct level of vision allowing the reading of instructions, the distinction of shapes and colours and the understanding of shapes and images presented in cognitive tasks (subjectively attested by the patient) Correct hearing level, allowing a good understanding of the sounds presented (subjectively attested by the patient and the assessor at the first contact for eligibility) Inclusion criteria for patients: Suffering from one of the behavioural addiction explored Beginning treatment in the Addictology department of the University Hospital of Nantes Inclusion criteria for healthy volunteers: - Free from the explored behavioural addictions Exclusion Criteria for all participants: Current and not stabilized psychiatric and addictive disorders (mood disorders, anxiety disorders and substance-use disorders except nicotine, lifetime psychotic syndrome), diagnosed by the MINI and after consultation with the clinician, Non stabilized endocrine disorders Neurological disorders (such as head trauma, neurodegenerative diseases, unbalanced epilepsy, mental retardation, etc.), Taking a psychotropic treatment wich is not stabilized for at least 2 weeks, Consumption of a psychoactive substance - other than nicotine - within the 12 hours prior to the assessment, Color blindness Cardiac problems self-reported by the patient, in order to avoid bias in the measurement of cardiac parameters, Electrical implants as declared by the participant (to avoid measurement artifacts) Having benefited from current or past cognitive remediation program Reporting being pregnant or breastfeeding Current participation or in the past month in a pharmacological research protocol Presenting difficulties for reading or writing French Being under guardianship With significant cognitive impairment not compatible with de cognitive assessment Exclusion criteria for healthy volunteers : - Suffering from one of the behavioural addiction explored

Ages Eligible for Study
-----------------
Minimum Age: 15 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Patients with behavioral addictions<br>Patients suffering from behavioural addiction (sexual addiction, excessive use of video games and eating disorders with bulimia episodes) will be recruited | Behavioral: Cognitive and clinical assessment<br>* The content of the assessment will be the same for all subjects and will consist of a cognitive assessment (neurocognition, social cognition, metacognition, emotional reactivity) and a clinical assessment (impulsivity, personality, psychiatric and addictive comorbidities)<br>|
| Other: Healthy volunteers<br>Healthy volunteers will be matched on gender, age and education level to patients | Behavioral: Cognitive and clinical assessment<br>* The content of the assessment will be the same for all subjects and will consist of a cognitive assessment (neurocognition, social cognition, metacognition, emotional reactivity) and a clinical assessment (impulsivity, personality, psychiatric and addictive comorbidities)<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Scores obtained at the various neurocognitive tests used | A composite score will be created to reflect the overall level of cognitive performance of individuals with behavioral addictions, compared to healthy controls | 4 hours | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Behavioral addiction, neurocognition, neuropsychology, sexual addiction, internet gaming disorder, eating disorders