Effects of COVID-19 Induced Deconditioning After Long-term High Intensity Resistance Exercise

Study Overview
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Brief Summary
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Osteosarcopenia designates the simultaneous presence of sarcopenia and osteopenia; both chronic conditions of advanced age. Dynamic-resistance exercise (DRT) might be the most powerful agent to fight osteosarcopenia. Indeed, in the present FrOST study, we clearly determine the positive effect of slightly adapted 18 month high-intensity (HIT)-DRT on bone mineral density (BMD), sarcopenia and other health related parameters in osteosarcopenic men. However, after a short training break, COVID-19 induced lock down prevented a re-start of the HIT resistance exercise training in the FrOST cohort. The aim of the present observational study is thus to determine the effects of 6 months of deconditioning on health related parameters under special regard of osteosarcopenia in this cohort of older men with osteosarcopenia.

Official Title
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Effects of COVID-19 Induced Deconditioning After Long-term High Intensity Resistance Exercise in Older Men With Osteosarcopenia A Randomized Controlled Trial

Conditions
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Osteoporosis, Sarcopenia

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: participants of the FrOST study (NCT03453463) Exclusion Criteria: medication and diseases with potential impact on study outcomes during the last 26 weeks.

Ages Eligible for Study
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Minimum Age: 74 Years
Maximum Age: 95 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| HIT-resistance exercise<br>High Intensity Resistance Exercise | |
| Non exercising control<br>Control group that maintained life style and physical activity habits | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| SMI | Skeletal muscle mass index (appendicular skeletal muscle mass / body height; kg/m2) as determined by Dual Energy x-Ray Absorptiometry | Change from Baseline to 26 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| BMD-LS | Bone Mineral Density at the Lumbar Spine as determined by Dual Energy x-Ray Absorptiometry | Change from Baseline to 26 weeks | 
| BMD-hip | Bone Mineral Density at the total hip as determined by Dual Energy x-Ray Absorptiometry | Change from Baseline to 26 weeks | 
| Sarcopenia-Z-Score | Z-Score of parameters constituting the metabolic syndrome (i.e. SMI, hand-grip strength, gait velocity) | Change from Baseline to 26 weeks | 
| Fat infiltration thigh muscles | Intramuscular adipose tissue at the mid thigh as determined by Magnetic Resonance Imaging | Change from Baseline to 26 weeks | 
| Fat infiltration para-vertebral muscles | Intramuscular adipose tissue at the mid thigh as determined by Magnetic Resonance Imaging | Change from Baseline to 26 weeks | 
| Maximum hip-/leg extensor strength | Maximum hip-/leg extensor strength as determined by an isokinetic leg press | Change from Baseline to 26 weeks | 
| Metabolic Syndrome Z-Score | Metabolic Syndrome Z-Score based on the definition of the International Diabetes Federation including waist circumference, resting glucose, HDL-cholesterol, triglyzerides, mean arterial blood pressure) | Change from Baseline to 26 weeks | 
| Self rated physical performance | Late-Life Function and Disability Index of McAuley et al. | Change from Baseline to 26 weeks |