linjc16/ctgov huggingface dataset:
Anecortave Acetate Risk-Reduction Trial (AART)

Study Overview
=================
Brief Summary
-----------------
The purpose of this study was to demonstrate that Anecortave Acetate for Depot Suspension (15 mg or 30 mg) is safe and effective in arresting the progression of non-exudative (dry) age-related macular degeneration in patients who are at risk for progressing to exudative (wet) age-related macular degeneration.

Official Title
-----------------
Efficacy and Safety of Posterior Juxtascleral Administrations of Anecortave Acetate for Depot Suspension (15 mg or 30 mg) Versus Sham Administration in Singaporean Patients at Risk for Progressing to Exudative Age-Related Macular Degeneration (AMD)

Conditions
-----------------
AMD

Intervention / Treatment
-----------------
* Drug: Anecortave Acetate Sterile Suspension, 30 mg/mL
* Drug: Anecortave Acetate Sterile Suspension, 60 mg/ML
* Other: Anecortave Acetate Vehicle


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Dry AMD in study eye, Wet AMD in non-study eye; Other protocol-defined inclusion criteria may apply. Exclusion Criteria: Under 50; Other protocol-defined exclusion criteria may apply.

Ages Eligible for Study
-----------------
Minimum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 15 mg Anecortave Acetate<br>Anecortave Acetate Sterile Suspension, 30 mg/mL, one injection of 0.5 mL in the study eye every 6 months for 48 months | Drug: Anecortave Acetate Sterile Suspension, 30 mg/mL<br>* Posterior juxtascleral administration of suspension<br>|
| Experimental: 30 mg Anecortave Acetate<br>Anecortave Acetate Sterile Suspension, 60 mg/mL, one injection of 0.5 mL in the study eye every 6 months for 48 months | Drug: Anecortave Acetate Sterile Suspension, 60 mg/ML<br>* Posterior juxtascleral administration of suspension<br>|
| Sham Comparator: Anecortave Acetate Vehicle<br>Anecortave Acetate Vehicle, one sham injection in the study eye every 6 months for 48 months | Other: Anecortave Acetate Vehicle<br>* Sham posterior juxtascleral administration of suspension<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Proportion of patients with sight-threatening CNV in study eye |  | Month 48 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time to development of sight-threatening CNV |  | Up to 48 months | 
| Proportion of patients with stable vision |  | Up to 48 months |
Pancreas Volume and Diabetes Status Following Pancreatectomy

Study Overview
=================
Brief Summary
-----------------
This study will enroll 100 patients scheduled to undergo a pancreatectomy. The primary objective is to develop a scoring system using pancreatic volume measured by CT scan and intraoperative measurements of the pancreas parenchyma to predict the onset of diabetes mellitus after a pancreatectomy. The investigators will also monitor patients with pre-existing diabetes to see if their diabetes worsens or improves.

Detailed Description
-----------------
The primary objective is to develop a scoring system using pancreatic volume measured by CT scan and intraoperative measurements of the pancreas parenchyma to predict the onset of diabetes mellitus after a pancreatectomy. The investigators will also monitor patients with pre-existing diabetes to see if their diabetes worsens or improves. Patients will be followed up to one year to track their diabetes status, postoperative outcomes and quality of life.

Official Title
-----------------
Using Pancreatic Volumetric to Determine the Onset of Diabetes Mellitus and Postoperative Outcomes After Pancreatectomy

Conditions
-----------------
Pancreatic Neoplasms

Intervention / Treatment
-----------------
* Procedure: Pancreatectomy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All patients undergoing pancreatectomy at our institution (e.g., pancreaticoduodenectomy, distal pancreatectomy, distal pancreatectomy and splenectomy, central pancreatectomy). Exclusion Criteria: All patients who are on steroids or other medications whose potential side effects include development of diabetes mellitus or elevated blood glucose. Pregnant or nursing women. Patients with uncontrolled diabetes (HbA1c >8%).

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Pancreatectomy<br>Patients scheduled to undergo a pancreatectomy | Procedure: Pancreatectomy<br>* Patients will undergo pancreatectomy as part of routine care for their pancreatic neoplasms.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percent resected volume of pancreas and diabetes development |  | Postoperative up to one year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| QLQ-C30 Quality of Life Health Questionnaire |  | Postoperative up to one year | 
| Blood glucose control |  | Postoperative up to one year |
Investigation of the Reliability of Ultrasonography Usage in the Diagnosis of Temporomandibular Joint Diseases

Study Overview
=================
Brief Summary
-----------------
In the literature, temporomandibular joint diseases on the diagnostic value of the use of ultrasonography in diagnosis studies are lacking. In this study in the diagnosis of temporomandibular joint diseases revealing the reliability of the use of ultrasonography. It is aimed to contribute to the literature in terms of.

Official Title
-----------------
Investigation of the Reliability of Ultrasonography Usage in the Diagnosis of Temporomandibular Joint Diseases: A Prospective Study

Conditions
-----------------
Device Reliability

Intervention / Treatment
-----------------
* Diagnostic Test: Ultrasonography


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients over the age of 18 who apply with TMJ problems Patients with pain in the joint and chewing muscle area Exclusion Criteria: Syndromic patients Patients under the age of 18 Patients with a history of orthognathic surgery Pregnants Antidepressant Users Patients Using Removable Dentures Patients who have had joint treatment in the past six months

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group I<br>In volunteers in Group 1, values obtained using a linear probe will be compared. | Diagnostic Test: Ultrasonography<br>* Temporomandibular joint diseases of ultrasonography its effectiveness and reliability in diagnosis disadvantages in MR and other imaging methods be ruled out.<br>|
| Group II<br>In volunteers in Group 2, values obtained using a hockey stick probe will be compared. | Diagnostic Test: Ultrasonography<br>* Temporomandibular joint diseases of ultrasonography its effectiveness and reliability in diagnosis disadvantages in MR and other imaging methods be ruled out.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Joint Pain Scale | Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) form will be used in our study | 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Ultrasonography
Menopause Sample Collection

Study Overview
=================
Brief Summary
-----------------
This study will provide daily urine samples from women during early and late stage peri-menopause as well as post-menopause over the course of three calendar months in order to maintain the SPD sample bank. Urine samples will be received in the clinical laboratory and aliquoted into 2.25ml amounts and stored at -80˚C until required. Symptom information will also be recorded to determine whether there are any noticeable physiological changes that can be related to stage of the menopause.

Official Title
-----------------
Menopause Sample Collection

Conditions
-----------------
Menopause

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Female Between the ages of 45 and 60 years Suspects they are going through or have been through the menopause Experiencing cycle irregularities: Early Stage Peri-Menopause: Mild cycle irregularity over the last 3-6months (minimum), variation of >6 days in length between consecutive cycles including shortened and longer cycles (but not >60 days in length) Late stage peri-menopause: Irregular cycles with prolonged periods of amenorrhea >60 days in length (but less than 12 months) Post-Menopause: Greater than 12 months since last menstrual period Willing to give informed consent Exclusion Criteria: Use of hormone replacement therapy (HRT) Use of hormone contraception Hysterectomy and/or oophorectomy Pregnant or breast feeding Other medical reason for amenorrhea (absence of menstruation)

Ages Eligible for Study
-----------------
Minimum Age: 45 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Early Stage Peri-Menopause<br>Mild cycle irregularity over the last 3-6months (minimum), variation of >6 days in length between consecutive cycles including shortened and longer cycles (but not >60 days in length) | |
| Late Stage Peri-Menopause<br>Late stage peri-menopause: Irregular cycles with prolonged periods of amenorrhea >60 days in length (but less than 12 months) | |
| Post-Menopause<br>Greater than 12 months since last menstrual period | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of daily urine samples collected from women during various stages of the menopause | Daily urine samples collected | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Menopause Symptom Information | Daily recording of experience of a range of menopause symptoms | 3 months |
Follow Up Study for Treatment of Parkinson's Disease With Subthalamic Deep Brain Stimulation

Study Overview
=================
Brief Summary
-----------------
This study aims to evaluate the long term effect of deep brain stimulation in the the subthalamic nucleus (STN) in patients with Parkinson's disease.

Official Title
-----------------
Long Term Study of Subthalamic Deep Brain Stimulation for Parkinson's Disease

Conditions
-----------------
Parkinson Disease

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Idiopathic Parkinson's disease Disease duration longer than 15 years Had STN deep brain stimulation implant more than 10 years Available and willing to be followed-up according to study protocol Exclusion Criteria: Patients with serious diseases such as tumor, sever liver or kidney dysfunction were not selected in the clinical trials Epilepsy Pregnant female History of severe neuropsychiatric disease Patients are taking part in other clinical trials in recent several months

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| STN DBS<br>Parkinson's disease (PD) patients who underwent deep brain stimulation (DBS) of the subthalamic nucleus (STN) | |
| CONTROL<br>Parkinson's disease (PD) patients received optimized medical treatment according to published evidence based guidelines | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changs in the score of Stand-Walk-Sit Test |  | above 10 years post surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of the score in United Parkinson Disease Rating Scale (UPDRS) part III |  | above 10 years post surgery | 
| UPDRS part I score |  | above 10 years post surgery | 
| UPDRS part II score |  | above 10 years post surgery | 
| UPDRS part IV score |  | above 10 years post surgery | 
| 39-Item Parkinson´s Disease Questionnaire (PDQ-39) score |  | above 10 years post surgery | 
| Freezing of Gait Questionnaire (FOG-Q) score |  | above 10 years post surgery | 
| Gait and Falls Questionnaire (GFQ) score |  | above 10 years post surgery | 
| Mini-Mental State Examination (MMSE) score |  | above 10 years post surgery | 
| Montreal Cognitive Assessment (MoCA) Beijing score Version |  | above 10 years post surgery | 
| Frontal Assessment Battery (FAB) score |  | above 10 years post surgery | 
| Hamilton Anxiety Scale (HAMA) score |  | above 10 years post surgery | 
| Hamilton Depression Scale-17 (HAMD-17) score |  | above 10 years post surgery | 
| Apathy Evaluation Scale score |  | above 10 years post surgery |
Inflammatory Response as a Prognostic Factor of Recurrence of Atrial Fibrillation After Ablation

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to evaluate inflammatory response as a prognostic factor of atrial fibrillation recurrency after ablation. Inflammatory response will be assessed by double measurement of C-reactive protein, fibroblast growth factor 2 (FGF2), matrix metallopeptidase 8 (MMP8) and body temperature. Dynamics of change of troponin I will be measured additionally. After ablation each patient will be monitored with ECG telemonitoring system for 7 days.

Official Title
-----------------
Assessment of Course of Inflammatory Biomarkers Concentrations After Pulmonary Veins Isolation as a Prognostic Factor of Atrial Fibrillation Treatment Effectiveness (ACtIVE-AF Study)

Conditions
-----------------
Atrial Fibrillation

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: signed consent; criteria for ablation of atrial fibrillation. Exclusion Criteria: previous pulmonary veins isolation; ablation other than pulmonary veins isolation during the procedure; atrial fibrillation at the beginning of ablation procedure; usage of 'single shot' devices.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Atrial fibrillation within the first 7 days after ablation |  | within the first 7 days after ablation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Atrial fibrillation within 6 months after ablation |  | 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Atrial Fibrillation, Biomarkers, Inflammatory Response, C-reactive protein, FGF2, MMP8, troponin I, body temperature
Music in Wide Awake Hand Surgery

Study Overview
=================
Brief Summary
-----------------
Wide awake local anesthesia no tourniquet (WALANT) surgery has emerged as a popular technique in hand surgery over the last decade. It is possible that the unfamiliar sounds of the operating room could contribute to intraoperative patient anxiety during WALANT surgery. This study intends to investigate whether utilizing noise cancelling headphones and listening to music intraoperatively during WALANT hand surgery has an effect on patient anxiety, pain, and satisfaction.

Official Title
-----------------
Music in Wide Awake Local Anesthesia no Tourniquet (WALANT) Hand Surgery: Prospective Randomized Control Trial

Conditions
-----------------
Hand Surgery

Intervention / Treatment
-----------------
* Procedure: Intraoperative Music


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age ≥ 18 years old Already chose to undergo WALANT hand surgery with the participating surgeon Exclusion Criteria: - Age <18 years old

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Hand Surgery with Music<br>Participant undergoes surgery hand surgery using Wide Awake Local Anesthesia with no tourniquet (WALANT) while listing to music | Procedure: Intraoperative Music<br>* Hand Surgery performed with the participant awake, using local anesthesia. Headphones will be worn by the participant and surgery will be performed while the participant is listening to music<br>|
| No Intervention: Hand Surgery without Music (Control Group)<br>Participant undergoes surgery hand surgery using Wide Awake Local Anesthesia with no tourniquet (WALANT) without listening to music | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patient anxiety levels will be recorded on a 10 point VAS scale | Participant Satisfaction | 3 hours |
Endoscopic Findings of Gastritis in Children

Study Overview
=================
Brief Summary
-----------------
Gastritis defines any (histologically confirmed) inflammation of the gastric mucosa

Detailed Description
-----------------
Gastritis is a very common disease in children. The main presentation of children with gastritis is recurrent abdominal pain and dyspepsia or vomiting. Young children may have hematemesis or melena as presentation. Drug induced or food related gastritis presents usually with acute symptoms but Helicobacter pylori gastritis have mainly recurrent abdominal pain and dyspeptic symptoms. Other presentations include diarrhea, constipation, flatulence, bloating, fatigue, low energy level, weight loss, muscle loss, bad breath etc. The main causes of gastritis are infections, inflammation and other disorders affect the gastric mucosa in pediatric patients. Helicobacter pylori infection is the most common cause of gastritis in children which is also responsible for the majority of duodenal ulcers. Acute erosive gastritis is most commonly the result of metabolic stress or drug or corrosive injury. Other major causes of gastritis include celiac disease, allergic disorders, and Crohn's disease .Medication as NSAIDs, uremia, ischemia, shock, radiation, sepsis, trauma, severe burns and surgery. Endoscopic pictures in acute gastritis may be in the form of: Multiple round-shaped severe erosions with a diameter of several millimeters. Mucosal edema, hyperemia. Peptic ulcer While in chronic gastritis is variable. Affects the antrum in the beginning and advances to the proximal in time .

Official Title
-----------------
Retrospective Study on Endoscopic Findings of Gastritis in Children Attending GIT Endoscopic Unit of Assiut University Children Hospital (AUCH) (15 Years)

Conditions
-----------------
Gastritis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All children diagnosed as gastritis by upper endoscopy and bio gastric biopsy Exclusion Criteria: • All children underwent upper endoscopy during the study period not diagnosed as gastritis

Ages Eligible for Study
-----------------
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| causes of gastritis in children as shown by upper endoscopy | infections inflammation Helicobacter pylori Acute erosive gastritis | average 1 year |