linjc16/ctgov huggingface dataset:
Strategies to Promote Physical Activity

Study Overview
=================
Brief Summary
-----------------
Getting regular physical activity has many health benefits. Current physical activity programs often encourage people to track their physical activity as a way to motivate them to continue being physically active over time. However, not everyone enjoys physical activity, so tracking physical activity may not be very motivating. This research study will evaluate whether a new program-specifically designed to enhance people's enjoyment of physical activity-improves people's attitudes toward physical activity compared to a program that encourages people to track their physical activity with a mobile app.

Official Title
-----------------
Strategies to Promote Physical Activity

Conditions
-----------------
Obesity

Intervention / Treatment
-----------------
* Behavioral: Fun First
* Behavioral: Close at Hand


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 25 ≤ BMI ≤ 39 kg/m2 Systolic blood pressure 120-139 mmHg and/or diastolic blood pressure 80-89 mmHg Not currently taking medications for blood pressure Exclusion Criteria: Not free of diagnosed heart disease, diabetes, and cancer Medical contraindications to regular, unsupervised physical activity Not stable on all medications over the past 3 months Not free of binge eating disorder or bulimic compensatory symptoms No regular access to a mobile phone and Internet Not able to speak and understand English Currently pregnant or planning to be within the next year Planning to move in the next year Not willing to be randomized

Ages Eligible for Study
-----------------
Minimum Age: 21 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Fun First<br>Strategies to promote enjoyment of physical activity | Behavioral: Fun First<br>* 8 weekly interactive small-group sessions with a health coach<br>|
| Active Comparator: Close at Hand<br>Strategies to promote tracking of physical activity | Behavioral: Close at Hand<br>* 8 weekly check-ins with a state of the art, engaging mobile app<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in self-reported enjoyment of physical activity assessed with the Behavioral Regulation in Exercise Questionnaire Version 2 (BREQ-2) Intrinsic Regulation subscale | Survey questions | Change from baseline to 2 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in self-reported physical activity assessed with the Stanford Leisure-Time Categorical Item (L-Cat) | Survey question | Change from baseline to 2 months |
REWARDS-Angina at Follow up Post Stenting

Study Overview
=================
Brief Summary
-----------------
Single center, retrospective registry to collect data regarding the rate of angina (any and CCS clas III/IV) within 12 months post stent implantation. In addition, the target vessel revascularization rate within 12 months post stent implantation.

Detailed Description
-----------------
The objective of this study is to retrospectively identify the rate of angina (any as well as CCS class III/IV) up to one (1) year following stent implantation. The following drug eluting stents will be evaluated in addition to bare metal stents; Cypher, Taxus Express, Xience V, Resolute and Promus Element. The target vessel revascularization rate will also be compared for the 6 stent types within one (1) year.

Official Title
-----------------
REWARDS-Angina at Follow up Post Stenting

Conditions
-----------------
Rate of Angina

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients, male or female, > 18 years of age, Patients who received at least one (1) commercially available Drug Eluting Stent or Bare Metal Stent: Cypher, Taxus Express, Xience V, Promus Element, Resolute, or Bare Metal Stents Exclusion Criteria: Received more than one type of DES as listed above or both a BMS and DES (as listed above)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cypher<br>Access rate of angina including degree, post PCI up to 1 year for the Cypher stent. | |
| Taxus Express<br>Access rate of angina including degree, post PCI up to 1 year for the Taxus Express stent. | |
| Xience V<br>Access rate of angina including degree, post PCI up to 1 year for the Xience V stent. | |
| Promus Element<br>Access rate of angina including degree, post PCI up to 1 year for the Promus stent. | |
| Resolute<br>Access rate of angina including degree, post PCI up to 1 year for the Resolute stent. | |
| Bare metal stents<br>Access rate of angina including degree, post PCI up to 1 year for bare metal stents. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of Angina | post PCI for a variety of DES and BMS | up to 1 year |
Sociodemographic Factors and Occupational Balance

Study Overview
=================
Brief Summary
-----------------
Occupational balance is a concept related to health and well-being. Therefore, determining the factors affecting this concept is important for health promotion interventions. There is no study in the literature on the relationship between socio-demographic factors and occupational balance. The results of this study are thought to provide new information to the literature.

Detailed Description
-----------------
Occupational balance is about the perception of having the 'right mix' of activities in life. This balance is analyzed according to types of activity such as self-care, productivity and leisure time, as well as different dimensions such as the physical, mental and social dimensions required to engage in activities. Occupational balance is a concept related to health and well-being. Therefore, determining the factors affecting this concept is important for health promotion interventions. There is no study in the literature on the relationship between socio-demographic factors and occupational balance. The results of this study are thought to provide new information to the literature.

Official Title
-----------------
Do Sociodemographic Factors Affect Occupational Balance?

Conditions
-----------------
Occupational Balance

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Being between the ages of 19-70 Agree to participate in the study - Exclusion Criteria: <19 years of age, >70 years of age

Ages Eligible for Study
-----------------
Minimum Age: 19 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Occupational Balance Questionnaire Balance Questionnaire (OBQ11-T) | The OBQ is a scale that measures self-rated occupational balance in different dimensions.It contains 11 items and 4 response categories.Each item in the scale is scored on a 4-point scale from 'strongly disagree' to 'strongly agree'. The total score is obtained by summing the individual items and ranges from 0 to 33, with higher scores indicating higher occupational balance. | 3 months |
Multicentre Study to Explore the Correlation Between Smoking Pattern and Clinical Efficacy of Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor (TKI) in Male Patients

Study Overview
=================
Brief Summary
-----------------
The objective is to investigate the correlation between smoking pattern and clinical efficacy of EGFR TKIs in male patients with locally advanced or metastasized non-small cell lung cancer of adeno histology who have failed 1st line chemotherapy. Health care resource usage, quality of life (EQ-5D) and practice of EGFR mutation test will also be evaluated. Current practice of EGFR mutation testing in Taiwan will be surveyed.

Official Title
-----------------
A Multi-centre, Naturalistic Study to Explore the Correlation Between Smoking Pattern and Clinical Efficacy of EGFR TKI in Male Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer of Adeno Histology Failed 1st Line Chemotherapy

Conditions
-----------------
Non Small Cell Lung Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Male patients age 20 years or older Histological or cytological confirmation of NSCLC of adeno histology. If sputum is the only available sample, a second positive test is necessary for cytological confirmation Locally advanced or metastatic on or after first-line chemotherapy. Imaging evidence of disease progression can be either chest X ray, CT or MRI assessment on measurable lesions. If no measurable lesion is available, evaluable lesions are acceptable

Ages Eligible for Study
-----------------
Minimum Age: 20 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>Male patients with non-small cell lung cancer (NSCLC) of adeno histology | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between smoking patterns and best objective tumor response rate |  | 6 Months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| correlation between smoking patterns and progression free survival (PFS) |  | 9 months | 
| correlation between smoking patterns and overall survival (OS) |  | 9 Months | 
| changes from baseline in quality of life questionnaires (EQ-5D) after EGFR-TKI therapy |  | 3 Months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
NSCLC, Male, Smoking Pattern, Efficacy
Reconstructive Surgical Approach for Pincer Nail

Study Overview
=================
Brief Summary
-----------------
A prospective design that studies the effects of a new technique for the treatment of pincer nails. The technique consists of a flattening of the bone of the distal phalanx with a frontal skin lifting that is performed in patients with a pincer nail deformity. Visual Analog Scale (VAS) will be measure before surgery, one month and one year after surgery.

Official Title
-----------------
Reconstructive Surgical Approach for Pincer Nail

Conditions
-----------------
Pincer Nail

Intervention / Treatment
-----------------
* Procedure: Surgery


Participation Criteria
=================
Eligibility Criteria
-----------------
Eligibility Criteria: Pincer nail deformity At least 5 years of pain in the nail Prior unsuccessful conservative treatments Exclusion Criteria: Medical or mental conditions that contraindicate surgical treatment of the condition.

Ages Eligible for Study
-----------------
Minimum Age: 16 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Surgery<br>Consists of a dorsal flattening of of the bone at the distal phalanx, with a frontal lifting of the distal skin of the toe | Procedure: Surgery<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Pain - 10 points Visual Analog Scale (VAS) |  | Change in Pain will be measured with a VAS: at baseline, after 1 month of treatment and after 1 year after treatment | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Pincer Nail, Surgery
LH/HCG Receptor Expression and Retrieval Rates

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate if there is an association between the serum LH receptor expression on the day of hCG administration or the day of oocyte retrieval and the retrieval rates at oocyte pick up

Detailed Description
-----------------
The purpose of this study is to evaluate if there is an association between the serum LH receptor expression on the day of hCG or the day of oocyte retrieval and the retrieval rates at oocyte pick up. For this purpose, m-RNA copy numbers will be assessed in the blood serum of patients undergoing ovarian stimulation for IVF on different days. Furthermore, detailed ultrasound scans will be perfomed, as well as assesment of hormonal levels during ovarian stimulation.

Official Title
-----------------
Association of LH/HCG Receptor Expression and Retrieval Rates at Oocyte Pick up.

Conditions
-----------------
Subfertility

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: Age <39 years, Body mass index (BMI) between 18 and 29 kg/m2, Presence of both ovaries, FSH levels <10 IU/l. Exclusion criteria: Endometriomas, Polycystic ovarian syndrome.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 39 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| LH/hCG receptor expression |  | at oocyte retrieval | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Subfertility, Luteinizing hormone, receptor
White Matter Integrity According to BDNF Genotype After Stroke

Study Overview
=================
Brief Summary
-----------------
The aim of this study was to investigate differential plastic changes of fractional anisotropy (FA) in the corticospinal tract (CST), the intrahemispheric corticocortical tract from the primary motor cortex to ventral premotor cortex (M1PMv) and the corpus callosum (CC) from 2 weeks to 3 months after stroke according to BDNF genotype.

Detailed Description
-----------------
The aims of this study were to investigate plastic changes in the fractional anisotropy (FA) of three motor-related white matter fibers according to the BDNF genotype from 2 weeks to 3 months after stroke onset; one is a the majority of fibers from M1 to medullary oblongata (CST), another is the intrahemispheric connection from M1 to ventral premotor cortex (M1PMv), and the other is the interhemispheric connection between bilateral M1s (CC). There were also to investigate the relationships between motor impairment and tract-related FA of white matter tracts in each BDNF genotype

Official Title
-----------------
Changes of White Matter Integrity According to BDNF Genotype During Motor Recovery After Stroke

Conditions
-----------------
Stroke

Intervention / Treatment
-----------------
* Other: observational study


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: diagnosed with first-ever hemispheric ischemic infarction with damage to the supratentorial area confirmed by brain MRI within 2 weeks after stroke onset Exclusion Criteria: any clinically significant or unstable medical disorder or neuropsychiatric comorbidity

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: observational study|This study is a longitudinal observational study|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fractional anisotropy | changes of fractional anisotropy (FA) in the corticospinal tract (CST) | 2 weeks to 3 months after stroke onset | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fractional anisotropy | changes of fractional anisotropy (FA) in the intrahemispheric corticocortical tract from the primary motor cortex to ventral premotor cortex (M1PMv) | 2 weeks to 3 months after stroke onset | 
| Fractional anisotropy | changes of fractional anisotropy (FA) in the corpus callosum (CC) | 2 weeks to 3 months after stroke onset |
Low Grade Inflammation in Type 1 Diabetes Children

Study Overview
=================
Brief Summary
-----------------
The study propose to measure the inflammation level in type 1 diabetes children with the cytokine analysis compared to non diabetic children of the same sibling and to healthy children.

Detailed Description
-----------------
The increase of type 1 diabetes incidence, particularly in young children leads to conduce new diagnostic and therapeutic strategies, notably for associated chronic morbidity.Measurement of chronic inflammation, with modification of the balance between pro-inflammatory cytokines and anti-inflammatory cytokines, could lead to detect patients with high risk to diabetes chronic morbidity. After parental consent, blood sampling will be carried out by micromethod for cytokine (500 µl) and CRPhs dosages and glycemia (100 µl) and glycated hemoglobin (1 µl). Urine will be collected (50 ml) in the morning for further researches.

Official Title
-----------------
Low Grade Inflammation in Type 1 Diabetes Children

Conditions
-----------------
Type 1 Diabetes, Inflammation

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Type 1 diabetes children group : Children aged 2 to 17 years Type 1 diabetes children Controlled group : Children aged 2 to 17 years Brother or sister of type 1 diabetes children Exclusion Criteria: Per os or inhaled corticoid in the previous month of inclusion Acute infectious disease in the previous week of inclusion Other chronic disease than diabetes type1

Ages Eligible for Study
-----------------
Minimum Age: 2 Years
Maximum Age: 17 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| diabetes group<br> | |
| control group<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Increase of Interleukine 6 in group DTI versus control group |  | Once at inclusion | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Increase of others cytokines (IL1-beta, l'IL-4, l'IL-10 and TNF alpha) and increase of High sensitivity CRP in group DTI versus control group |  | Once at inclusion | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
type 1 diabetes, children, low grade inflammation, cytokine, CRP
Validity of Digital Models Obtained With iTero® and Lava Digital® in Comparison With Plaster Models.

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate the validity, reliability and reproducibility of digital models obtained from iTero® and Lava Digital® in comparison with traditional plaster models.

Detailed Description
-----------------
The primary objective of this study is to evaluate the validity, reliability and reproducibility of the dental measurements obtained on the digital models with iTero® in comparison with those obtained on the plaster models (gold standard) and on the digital models with Lava Digital®. The secondary objective is to compare two different impression materials (i.e. alginate and polyvinylsiloxane (PVS)) and determine whether the impression material used affects the accuracy of the measurements. Statistical analysis: Intraclass correlation coefficient (ICC) will be used to evaluate the intra- and inter-operator reliability of the measurements for each method, i.e. the plaster models and the digital models. A paired t-test will be used to determine the validity of the digital measurements with iTero®, and to compare the impression materials (alginate and PVS). A Bland-Altman plot will also be used to compare the two digital methods (Lava Digital® et iTero®) with the plaster models. Dahlberg coefficient will be used to evaluate the technical error associated with the measurements that will be made.

Official Title
-----------------
Validity, Reliability and Reproducibility of Digital Models Obtained With iTero® (AlignTech) and Lava Digital® (3M) in Comparison With Plaster Models.

Conditions
-----------------
Dentition/Teeth Measurement

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Aged between 12 and 30 years old (male or female) complete permanent dentition from first molar to the other first molar no interproximal modifications (e.g. decay, large restorations, abnormal tooth morphology) which could affect the mesio-distal width of the teeth Exclusion Criteria: Dentition with severe crowding (that could therefore affect the mesio-distal width of the teeth)

Ages Eligible for Study
-----------------
Minimum Age: 12 Years
Maximum Age: 30 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overjet | Overjet: measured as the greatest horizontal distance from the labial surface of the lower central incisor to the most inferior point at the mesiodistal center of the upper central incisor | one year |