Effect of Glycopyrrolate and Atropine on Catheter-Related Bladder Discomfort

Study Overview
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Brief Summary
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We want to evaluate the efficacy of the glycopyrrolate and atropine for the prevention of catheter-related bladder discomfort.

Detailed Description
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The mechanism of catheter-related bladder discomfort is thought to be related to the muscarinic receptor. The adjuncts to reversal agents such as glycopyrrolate and atropine are known to block the muscarinic receptor in different ways. We want to evaluate the efficacy of the glycopyrrolate and atropine for the prevention of catheter-related bladder discomfort.

Official Title
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Effect of Glycopyrrolate and Atropine as Adjuncts to Reversal of Non-Depolarizing Neuromuscular Blocking Agents on Postoperative Catheter-Related Bladder Discomfort

Conditions
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Catheter Site Discomfort, Complications, Anesthesia, Urinary Bladder Neoplasms

Intervention / Treatment
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* Drug: Glycopyrrolate
* Drug: Atropine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients scheduled for transurethral bladder excision under general anesthesia ASA I-III Exclusion Criteria: Foley catheter less than 18 Fr. Patients with obstruction of urinary tract Patients with neurogenic bladder Patients with severe obesity Patients with neurologic disorder Patients with chronic pain Patients with allergic history to atropine or glycopyrrolate

Ages Eligible for Study
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Minimum Age: 19 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Glycopyrrolate<br>Glycopyrrolate will be administered as the adjuncts of neuromuscular blocker reversal agent. | Drug: Glycopyrrolate<br>* Glycopyrrolate will be administered.<br>|
| Active Comparator: Atropine<br>Atropine will be administered as the adjuncts of neuromuscular blocker reversal agent. | Drug: Atropine<br>* Atropine will be administered.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Catheter-related bladder discomfort | Catheter-related bladder discomfort will be measured at 1 hour postoperatively (0:none, 1:mild, 2:moderate, 3:severe). | 1 hour postoperatively | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Catheter-related bladder discomfort | Catheter-related bladder discomfort will be measured at 1 hour postoperatively (0:none, 1:mild, 2:moderate, 3:severe). | 0, 6 and 24 hour postoperatively | 
| Hemodynamic parameters | Mean blood pressure and heart rate will be measured at 0, 1, 5, 10 minute postoperatively. Measurement at 10 minute means Mean blood pressure and heart rate at the admission of post-anesthetic care unit. | 0, 1, 5, 10 minute postoperatively | 
| Nausea | Nausea will be measured at 0, 1, 6 and 24 hour postoperatively. | 0, 1, 6 and 24 hour postoperatively | 
| Vomiting | Vomiting will be measured at 0, 1, 6 and 24 hour postoperatively. | 0, 1, 6 and 24 hour postoperatively | 
| Dry mouth | Dry mouth will be measured at 0, 1, 6 and 24 hour postoperatively. | 0, 1, 6 and 24 hour postoperatively | 
| Flushing | Flushing will be measured at 0, 1, 6 and 24 hour postoperatively. | 0, 1, 6 and 24 hour postoperatively | 
| Blurred vision | Blurred vision will be measured at 0, 1, 6 and 24 hour postoperatively. | 0, 1, 6 and 24 hour postoperatively | 
| Dizziness | Dizziness will be measured at 0, 1, 6 and 24 hour postoperatively. | 0, 1, 6 and 24 hour postoperatively | 
| Analgesics | The amount of analgesics will be measured at 0, 1, 6 and 24 hour postoperatively. | 0, 1, 6 and 24 hour postoperatively |