Prediction of WMH in Migraine Using a BOLD-CVR Map

Study Overview
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Brief Summary
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Brain white matter hyperintensities (WMHs) are prevalent in migraineurs, of which the mechanism is still unclear. The investigators aimed to test the spatial association between areas with reduced cerebrovascular reactivity (CVR) to hypercapnic stimuli and consequent development of WMHs.

Detailed Description
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A whole-brain map of CVR will be created in patients with migraine and normal controls. Hypercapnic stimuli for CVR will be delivered by prospective end-tidal CO2 targeting device. Hemodynamic responses will be determined by BOLD signal changes using fMRI. WMHs will be determined by high-resolution 3D FLAIR imaging. Patients and controls will undergo serial MRIs with 1 year interval. Associations between areas of reduced CVR and consequent WMH development will be tested in both patients and controls.

Official Title
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Research of Brain White Matter Hyperintensity in Migraine Using a Cerebrovascular Reactivity Mapping Based on BOLD MRI

Conditions
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Migraine

Intervention / Treatment
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* Diagnostic Test: BOLD MRI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Migraineurs(patients) : age 18-50 years migraine with or without aura as defined by the third edition of the International Classification of Headache Disorders (ICHD-3 beta) migraine duration > 6 months episodic migraine feature headache (< 15 attacks/m) not any preventive medications for migraine Control: age 18-50 years no headache disorder requiring painkillers within the past year no more than moderate intensity of headache within the past year no headache disorder other than Infrequent episodic tension-type headache as defined by the ICHD-3 beta Exclusion criteria: chronic migraine within last month (≥15 attacks/m) medication overuse headache as defined by ICHD-3 beta other comorbid disease that may affect vascular function (Hypertension, diabetes, hyperlipidemia, cerebral infarction, smoking etc) can not breath 20 L for 1 minute because of basal cardiopulmonary disease (chronic obstructive pulmonary disease, heart failure etc) a disease that can be exacerbated by elevated PCO2 in blood (Interstitial lung disease, amyotrophic lateral sclerosis etc) predicted to be unable to write the headache diary due to cognitive decline contraindications to MRI pregnancy refusal to informed consent

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Control<br>Normal controls without headaches will undergo BOLD MRI with prospective CO2 targeting | Diagnostic Test: BOLD MRI<br>* Prospective End-tidal targeting RespirAct device(A specially designed gas blender and sequential rebreathing circuit) will be used to implement the gas targeting method which involves precise elevations in End-tidal PCO2 while maintaining a fixed End-tidal PO2 BOLD MR images will be obtained by using a T2*-weighted two-dimensional gradient-echo sequence with echoplanar readout.<br>|
| Migraineurs<br>Patients diagnosed with migraine based on the ICHD-3 beta will undergo BOLD MRI with prospective CO2 targeting | Diagnostic Test: BOLD MRI<br>* Prospective End-tidal targeting RespirAct device(A specially designed gas blender and sequential rebreathing circuit) will be used to implement the gas targeting method which involves precise elevations in End-tidal PCO2 while maintaining a fixed End-tidal PO2 BOLD MR images will be obtained by using a T2*-weighted two-dimensional gradient-echo sequence with echoplanar readout.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| CVR association with WMH development | The investigators will obtain a CVR map using BOLD MR signal in the first year of study and also obtain changes in WMH during 2 years of follow-up period in patients and controls, respectively. Then the investigators will test whether CVR-map predicts consequent WMH development in patients and controls, respectively. | 1-year follow-up (2nd year) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Spatial pattern of CVR | The investigators will obtain a CVR map for each voxel using BOLD MR signal in response to % increase in EtCO2 respectively in patients and controls. Spatial pattern of CVR will be compared between patients and controls. | baseline(1st year) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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White matter hyperintensity, Cerebrovascular reactivity