Cangrelor in Patients With Acute Myocardial Infarction Undergoing PCI After CPR, Ventilated or Cardiogenic Shock

Study Overview
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Brief Summary
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This registry will provide information about the efficacy and safety of cangrelor in a very high-risk group of patients with acute myocardial infarction undergoing PCI. It will not only include patients with cardiogenic shock, but a variety of patients not able to swallow tablets, such as those after CPR and/or with invasive or non-invasive ventilation. Therefore it will provide information about the use of cangrelor beyond the current knowledge.

Detailed Description
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This registry is a non-interventional, multicentre, retrospective cohort study in patients with acute myocardial infarction undergoing PCI after CRP, ventilated and/or with cardiogenic shock. The study is purely observational; data will be documented retrospectively based on available medical records. No additional data will be collected, no study-related treatment will be initiated. About 10 - 20 high-volume PCI clinics in Germany treating patients with myocardial infarction are eligible for participation. Participating sites will be given a maximum of 6 months for retrospectively documenting eligible patients. Eligible are all patients with acute myocardial infarction (STEMI, NSTEMI) who underwent PCI after CRP, ventilated and/or with cardiogenic shock and were treated with cangrelor during index procedure. It is planned to enrol about 400 patients in total. Patient characteristics, procedural details and clinical events occurring during the period between index MI and discharge or death (whichever came first) will be documented based on the relevant existing medical charts of the patients.

Official Title
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Cangrelor in Patients With Acute Myocardial Infarction Undergoing PCI After CPR, Ventilated or Cardiogenic Shock

Conditions
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Acute Myocardial Infarction

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age ≥18 years Acute Myocardial infarction (NSTEMI or STEMI) PCI with stent implantation Treatment with cangrelor during index procedure At least one of the following criteria: CPR prior to PCI Cardiogenic shock Heart failure with the need for mechanical or non-invasive ventila-tion Exclusion Criteria: No explicit medical exclusion criteria are stated to avoid selection bias.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Definite stent thrombosis | Rate of stent thromboses | from procedure for index MI up to 48 hours | 
| Recurrent myocardial infarction | Rate of recurrent myocardial infarction according to the universal definition of MI | from procedure for index MI up to 48 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Definite stent thrombosis | Rate of stent thromboses | from procedure for index MI until discharge from hospital or intrahosptal death, whichever came first; up to 30 days | 
| Recurrent myocardial infarction | Rate of recurrent myocardial infarction according to the universal definition of MI | from procedure for index MI until discharge from hospital or intrahosptal death, whichever came first; up to 30 days | 
| Bleeding complications | Rate of bleeding complication according to BARC definition | from procedure for index MI until discharge from hospital or intrahosptal death, whichever came first; up to 30 days | 
| Mortality | Rate of death | from procedure for index MI until discharge from hospital; up to 30 days |