Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis Collection

Study Overview
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Brief Summary
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Numerous neurological disorders affecting the central and peripheral nervous system can be attributed to the immune system through multiple effector mechanisms. However, current treatments could be drastically improved by faster and more accurate diagnosis. The sample collection will benefit to patients with rare neuroimmune syndromes such as Autoimmune Encephalitis (AE) and Paraneoplastic Neurological Syndromes (PNS) leading to a better and early diagnosis, as well as treatment improvement.

Official Title
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Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis Collection

Conditions
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Paraneoplastic Neurological Syndromes or Autoimmune Encephalitis

Intervention / Treatment
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* Biological: Collection of biological sample with sera, CSF, buffy coat, PBMC, plasma.


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient with consent Patient with well-characterized antibodies in serum or cerebrospinal fluid or not Patient with neurological disorder compatible with PNS or auto-immune encephalitis Exclusion Criteria: Refusal of consent Patient under guardianship
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Interventional Model Description: Blood sample
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Paraneoplastic neurological syndrome patients and autoimmune encephalitis patient<br>patients with diagnosis of paraneoplastic neurological syndrome or autoimmune encephalitis | Biological: Collection of biological sample with sera, CSF, buffy coat, PBMC, plasma.<br>* Blood is collected only one time by blood sample to obtain serum, buffy coat, plasma and PBMC. 2 *4ml of blood on dry tube 2 *4ml of blood on EDTA tube If possibility of delivery in 48 hours at the Centre of Biological Resources, 7*4ml of blood on heparin tube If cerebrospinal fluid has been drawn for diagnosis, remaining sample available will be stored in the collection<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood Samples | Assessment of biocollection of blood samples | 10 years | 
| Cerebrospinal fluid biocollection | Assessment of biocollection of Cerebrospinal fluid | 10 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Scientific collaboration | Number of project issued from the biocollection | 10 years | 
| Scientific | Number of scientific papers issued from the biocollection | 10 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Paraneoplastic Neurological Syndromes, Autoimmune Encephalitis, biological collection