Femoral frACturEs and COVID-19.

Study Overview
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Brief Summary
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Retrospective cohort study comparing the early prognosis after surgically-treated proximal femur fragility fractures in patients affected and not affected by COVID-19.

Official Title
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Femoral frACturEs and COVID-19. Retrospective Comparative Cohort Study on the Early Prognosis of Patients Affected by Proximal Femur Fractures and COVID-19.

Conditions
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Covid19, Femur Fracture, Fragility Fracture

Intervention / Treatment
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* Other: COVID-19


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age ≥45 years Admitted to IRCCS Orthopaedic Institute Galeazzi for proximal femur fractures from march 2020 to april 2020. Tested for COVID-19 through naso-pharyngeal swab analized with RT-PCR Exclusion Criteria: Age <45 years Not tested for SARS-CoV-2 Other fractures (including bilateral proximal femur fractures)

Ages Eligible for Study
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Minimum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Proximal femur fracture AND COVID-19<br>Surgical treatment of femur fracture | Other: COVID-19<br>* Patients affected versus not affected by COVID-19, with the same starting condition (proximal femur fracture)<br>|
| Proximal femur fracture NO COVID<br>Surgical treatment of femur fracture | Other: COVID-19<br>* Patients affected versus not affected by COVID-19, with the same starting condition (proximal femur fracture)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Survival at discharge day (comparison between the two groups) | Survival at discharge day (comparison between the two groups) | on discharge day, on average after 1 week | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Length of stay (comparison between the two groups) | Length of stay (comparison between the two groups) | on discharge day, on average 1 week | 
| Readmission rate (comparison between the two groups) | Readmission rate (comparison between the two groups) | up to 30 days after discharge | 
| Complications rate (comparison between the two groups) | Complications rate (comparison between the two groups) | up to 30 days after discharge | 
| Survival at 30 days after discharge (comparison between the two groups) | Survival at 30 days after discharge (comparison between the two groups) | 30 days after discharge | 
| Routine lab exams values (comparison between the two groups) | Routine lab exams values (comparison between the two groups) | At admission, 1st postoperative day, 5th postoperative day, on discharge day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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proximal femur fracture, fragility fracture, Covid-19, SARS-CoV2, FACE-COVID 19, prognosis, cohort study