Strain for Risk Assessment and Therapeutic Strategies in Patients With Acute Heart Failure (STRATS-AHF) Registry

Study Overview
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Brief Summary
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STRATS-AHF (STrain for Risk Assessment and Therapeutic Strategies in patients with Acute Heart Failure) registry enrolled 4,312 patients hospitalized for acute HF from 3 tertiary university hospitals (Seoul National University Bundang Hospital, Seoul National University Hospital, and Chungnam National University Hospital) from January 2009 through December 2016.

Detailed Description
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Patients with signs or symptoms of heart failure and either lung congestion, or objective findings of left ventricular (LV) systolic dysfunction or structural heart disease, were eligible for the study. Echocardiography was performed and both LV ejection fraction (LVEF) and LV global longitudinal strain (LV-GLS), right ventricular GLS (RV-GLS) were measured.

Official Title
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Strain for Risk Assessment and Therapeutic Strategies in Patients With Acute Heart Failure (STRATS-AHF) Registry

Conditions
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Heart Failure Acute, Heart Failure, Echocardiography

Intervention / Treatment
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* Diagnostic Test: Echocardiography with speckle-tracking imaging


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with signs or symptoms of HF and either lung congestion, or objective findings of LV systolic dysfunction or structural heart disease Exclusion Criteria: Patients who presented with acute coronary syndrome

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Acute heart failure<br>Patients hospitalized for acute heart failure and underwent echocardiography with speckle-tracking imaging | Diagnostic Test: Echocardiography with speckle-tracking imaging<br>* Measurement of left ventricular ejection fraction and global longitudinal strain Measurement of left atrial reservoir strain (peak atrial longitudinal strain) Measurement of right ventricular global longitudinal strain<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| All-cause mortality | Death from any cause | up to 5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hospitalization for heart failure | Any hospitalization for acute heart failure after the index hospitalization | up to 5 years | 
| Composite of all-cause mortality and hospitalization for heart failure | Death from any cause or any hospitalization for acute heart failure after the index hospitalization | up to 5 years | 
| Ischemic stroke | Ischemic stroke (an episode of neurological dysfunction caused by embolism) after the index hospitalization | up to 5 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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acute heart failure, global longitudinal strain, ejection fraction, echocardiography, mortality