linjc16/ctgov huggingface dataset:
Grass Sensitisation and Allergic Rhinitis in Thai Patients

Study Overview
=================
Brief Summary
-----------------
Allergic rhinitis patients are the patients who have nasal symptoms when triggered by indoor or outdoor allergens. Outdoor allergen can be divided into grass, tree, or weed. The type of grass or weed are different in various part of the world. The allergens from grass and weed has never been studied in Thailand. This study will find the major allergen from Bermuda grass, Johnson grass, Para grass, sedge, and ragweed, which are very common in Thailand. In addition, the investigators will study about the cross-reactivity among these group of allergen.

Detailed Description
-----------------
To find the major allergen of grass and weed, the serum of patients will be used to bind with the allergen extract by immunoblot study. The ELISA-inhibition will be used to study about cross-reactivity among various kinds of grass and weed.

Official Title
-----------------
The Study of Allergens From Grass and Weed Which Are Causes of Allergic Rhinitis in Thai Patients

Conditions
-----------------
Allergy to Grass Pollen, Allergic Rhinitis Due to Weed Pollens

Intervention / Treatment
-----------------
* Other: Immunoblot


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Allergic rhinitis patients age 10-50 years old Control: healthy volunteer age 18-50 years old Exclusion Criteria: Chronic illness such as cardiovascular diseases, liver diseases History of anaphylaxis Pregnancy

Ages Eligible for Study
-----------------
Minimum Age: 10 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Pollen Allergy<br>Pollen allergy and control will have the same intervention, ie. Skin prick test and collect serum samples.Then measure the specificIgE, immunoblot, and ELISA inhibition | Other: Immunoblot<br>* serum specific IgE binds to grass extract by immunoblot<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Grass, Major allergen, cross-reactivity
Gastric Plication and Banding

Study Overview
=================
Brief Summary
-----------------
The purpose of the study is to assess the efficacy of a hybrid laparoscopic surgical procedure for treatment of morbid obesity, Gastric Plication (G)) and Gastric Banding.

Official Title
-----------------
Treatment of Morbid Obesity With Gastric Plication and Gastric Banding

Conditions
-----------------
Morbid Obesity

Intervention / Treatment
-----------------
* Procedure: Plication


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age 18-70 BMI > or = to 30 and co-morbid conditions or BMI > or = to 40 Ability to provide informed consent Willingness to commit to long-term follow-up Exclusion Criteria: Inability to provide informed consent Presence of metabolic or medically correctable cause(s) for obesity, such as untreated hypothyroidism or Prader-Willi Contraindications to surgery such as myocardial infarction within last 6 months, end stage renal or liver disease, current infection, or other disease states contraindicative to surgery, in the principal investigator's opinion Pregnancy Plan to become pregnant within two years post-surgery Current addiction to drugs or alcohol Previous history of any type of bariatric surgery (de novo group only) Hiatal hernia > 3 cm

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Band/Plication<br>Treatment -- band/plication | Procedure: Plication<br>* Plication of the stomach will be performed in conjunction with placement of a gastric band.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Weight loss | The primary endpoint is weight loss two years post-surgery. | Two years | 
| Complications | Intra and post-operative complications will be tracked. | 2 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
morbid obesity, bariatric surgery, gastric banding, gastric plication
Distress in Crisis Situations During COVID-19

Study Overview
=================
Brief Summary
-----------------
There are many scales for screening or assessing the impact of a disease. These scales are generally used to diagnose or assess the severity of a disease and are carried out at the request of a physician by the patient. Conversational agents could make it possible to administer these questionnaires remotely, analyse them and use the results on a large scale, without prior medical intervention. The main objective of this study is to quantify and qualify the distress of a large population in times of pandemic crisis.

Detailed Description
-----------------
The Peritraumatic Distress Inventory is the standard tool designed to assess distress in times of crisis. It consists of 13 questions. Questions will be submitted to the participants from the Vik chatbot. Responses will be analysed and compared according to the demographics and pathologies encountered.

Official Title
-----------------
Distress During the COVID-19 Pandemic in France: a National Assessment of At-risk Populations

Conditions
-----------------
Stress, Psychological

Intervention / Treatment
-----------------
* Other: questionnaire assesment


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age > 18 years old Collection of the subject's non-opposition Patient registration on Vik breast, Vik asthma, Vik migraine, Vik depression Exclusion Criteria: Patient unable to formulate non-opposition

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Vik sein<br>Vik sein users | Other: questionnaire assesment<br>* questionnaire assesment<br>|
| Vik asthme<br>Vik asthme users | Other: questionnaire assesment<br>* questionnaire assesment<br>|
| Vik migraine<br>Vik migraine users | Other: questionnaire assesment<br>* questionnaire assesment<br>|
| Vik depression<br>Vik depression users | Other: questionnaire assesment<br>* questionnaire assesment<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| quantify and qualify distress over a large population in times of pandemic crisis. |  | 1 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| qualify demographic data vs distress over a large population in times of pandemic crisis. |  | 1 month |
Geriatric Polytrauma SOP

Study Overview
=================
Brief Summary
-----------------
This study investigated whether there were improvements in the in-hospital mortality, infection rate, and rate of palliative care among geriatric trauma patients after the implementation of new standard operating procedures (SOPs) for the resuscitation room. These new SOPs, comprising early whole-body computed tomography (CT), damage control surgery, and the use of goal-directed coagulation management, were designed for severely injured adult trauma patients

Detailed Description
-----------------
This study involved the analysis of a prospective single-centre database. Patients admitted via the resuscitation room with need for intensive care treatment after the resuscitation room phase were included and compared before the implementation of the new SOPs (between 1 January, 2000 and 31 December, 2006) and after their implementation in 2009 (between 1 January, 2010 and 31 December, 2012) of our level-I trauma centre.

Official Title
-----------------
Implementation of New Standard Operating Procedures for Geriatric Trauma Patients With Multiple Injuries

Conditions
-----------------
Geriatrics

Intervention / Treatment
-----------------
* Behavioral: Following new SOPs


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Inclusion in internal trauma database Exclusion Criteria: Comprised age < 65 years, ISS < 9, and transfers from other hospitals.

Ages Eligible for Study
-----------------
Minimum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| w/o SOP<br>Time period 1: 2000-2006, without new SOPs | Behavioral: Following new SOPs<br>* The new SOPs comprised early whole-body CT, damage control surgery, and the use of goal-directed coagulation management and are based on the ATLS® concept, which was the strictly followed protocol before implementation of the new SOPs<br>|
| SOP<br>Time period 2: 2010-2012, after implementation of the new SOPs | Behavioral: Following new SOPs<br>* The new SOPs comprised early whole-body CT, damage control surgery, and the use of goal-directed coagulation management and are based on the ATLS® concept, which was the strictly followed protocol before implementation of the new SOPs<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| In-hospital mortality | In-hospital mortality | 30 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Infections | Infections | 30 days | 
| Rate of palliative care | Rate of palliative care | 30 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Algorithm, In-hospital mortality, Multiple trauma, Standard of care
Assessment of Thigh Muscle After a Stretching Program

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to establish, through ultrasound, measurements of the thigh muscles (Biceps Femoris and Vastus Lateralis)and the chronic effects of a static stretching program on the muscle-tendon unit these muscles.

Official Title
-----------------
BICEPS FEMORIS AND VASTUS LATERALIS MUSCLE ARCHITECTURE AFTER A CHRONIC STRETCHING PROGRAM

Conditions
-----------------
Assessment of Muscle Architecture and Tendon After Chronic Stretching Program

Intervention / Treatment
-----------------
* Other: static stretching exercise on 3 times a week during 8 weeks. Sets number: three of 30 seconds with intervals of equal duration


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: physically active male volunteers soldiers of the Army School of Physical Education of Rio de Janeiro, Brazil young men Exclusion Criteria: any musculoskeletal disorder in the lower limbs neurological or cardiovascular disease experienced previous to or reported during the study.

Ages Eligible for Study
-----------------
Minimum Age: 17 Years
Maximum Age: 25 Years

Sexes Eligible for Study
-----------------
Male

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science


Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: static stretching exercise on 3 times a week during 8 weeks. Sets number: three of 30 seconds with intervals of equal duration|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Assessment of Thigh Muscle After a Stretching Program |  | after 8 weeks that static stretching protocol was applied |
Maternal and Infant Health and Breast Milk Study in South China

Study Overview
=================
Brief Summary
-----------------
The purpose of this study was to investigate the nutrients in breast milk of Chinese mothers and its related factors, as well as exploring the early development of infants.

Detailed Description
-----------------
Breast milk contains a variety of nutrients that are beneficial to the early development of infants, such as lipids, Vitamins and so on. At present, the level of these nutrients in milk and infant formula are lower and which are present in a different form from that in breast milk. Therefore, this study was designed to investigate the level of nutrients in breast milk of Chinese mothers and learn about its related factors, as well as exploring the relationships between these nutrients and the early development of infants.

Official Title
-----------------
Maternal and Infant Health and Breast Milk Study in South China

Conditions
-----------------
Healthy

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age 20-45 years natural delivery, singleton pregnancy healthy term infants（at 37-42 weeks of pregnancy） don't smoke and drink self-evaluation as physical health breastfeeding at least until three months of age Apgar score > 8 sign informed consent Exclusion Criteria: suffering from mastitis gestational diabetes, hypertension and other metabolic diseases AIDS, tuberculosis and other acute or chronic infectious diseases severe heart and kidney diseases mental system diseases cancer and other malignant consumptive disease take drugs that affect nutrient metabolism infants with congenital and genetic diseases with lactation contraindications don't agree to sign informed consent

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The level of nutrients in breast milk samples | The nutrients were detected from breast milk samples of mothers by chemical analysis | 14 months | 
| The level of nutrients in blood samples | The nutrients were detected from blood samples of mothers and infants by chemical analysis | 14 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| General demographic materials | The general demographic materials of mothers were obtained by questionnaire or medical treatment records | 14 months | 
| Dietary and lifestyle information | Dietary and lifestyle information of mothers were obtained by Food Frequency Questionnaire and 24-hour meal review questionnaire | 14 months | 
| Health follow-up | Dietary and health outcome of infants were obtained by questionnaire or medical treatment records | 14 months |
Mannheim Register of Sepsis and Septic Shock

Study Overview
=================
Brief Summary
-----------------
The study aims to investigate clinically and prognostically relevant parameters in patients with sepsis and septic shock within a monocentric observational clinical register.

Detailed Description
-----------------
All consecutive septic patients at the internists intensive care Unit (ICU) at the University of Mannheim are included in the register and follow up during ICU stay and after that. Data of patients' admission status, septic focus, baseline parameters, and comorbidities are collected. Extensive information about echocardiography, electrocardiography, and imaging procedures are included in the register. Laboratory values, microbiological investigations, organ dysfunction and organ replacement therapies, medication, adverse events, and complications were recorded for several days during the ICU stay (days 1, 2,3, 5,7, and 10). Standard scores for critically ill patients were calculated for the day before admission at the ICU if available, and several time points during the ICU stay. The register includes information about the mortality during ICU stay, 30-day mortality, 6-month mortality, and septic patients' 1-year mortality.

Official Title
-----------------
Mannheim Register of Sepsis and Septic Shock

Conditions
-----------------
Severe Sepsis, Septic Shock

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Sepsis and septic shock according to current guidelines Exclusion Criteria: other forms of shock not associated with an infection
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| all-cause mortality |  | 30 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| all-cause mortality |  | in hospital | 
| all-cause mortality |  | 12 months |
The In Vitro Fertilization - Lipiodol Uterine Bathing Effect Study

Study Overview
=================
Brief Summary
-----------------
The hypothesis of this study is that Lipiodol uterine bathing improves the success rate of in vitro fertilization (IVF) for women with endometriosis or recurrent IVF implantation failure.

Official Title
-----------------
The in Vitro Fertilisation - Lipiodol Uterine Bathing Effect Study

Conditions
-----------------
Endometriosis, In Vitro Fertilization Implantation Failure

Intervention / Treatment
-----------------
* Procedure: Lipiodol + IVF
* Procedure: IVF


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 12 or more months infertility Age 18 to 39 Endometriosis or recurrent IVF implantation failure Patent fallopian tubes Exclusion Criteria: Iodine allergy Blocked fallopian tube or tubes

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 39 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Recurrent IVF implantation failure<br> | Procedure: Lipiodol + IVF<br>* IVF preceded by lipiodol<br>Procedure: IVF<br>* IVF alone<br>|
| Experimental: Endometriosis<br> | Procedure: Lipiodol + IVF<br>* IVF preceded by lipiodol<br>Procedure: IVF<br>* IVF alone<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Live birth |  | 12 months post-randomization | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical pregnancy |  | 3 months post-randomization | 
| Adverse events |  | 3 & 12 months post-randomization | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
recurrent IVF implantation failure
Long Term Follow up Patients With Premature Ovarian Failure ex Vivo Gene Therapy

Study Overview
=================
Brief Summary
-----------------
This is a multi-centers of long term safety and efficacy follow up study for patients with premature ovarian failure (the women aged younger than 40 years, who present with amenorrhoea, hypergonadotropic hypogonadism, and infertility) who have been treated with ex vivo gene therapy drug product in Institute of Bio-Stem Cell Rehabilitation UAB - sponsored clinical studies. After completing the parent clinical study (approximately 6 month), eligible subject will be followed for additional 2 years for total of 2 years and 6 month post drug product infusion. No investigation drug product will be administered in the study

Official Title
-----------------
Long Term Follow up Patients With Premature Ovarian Failure ex Vivo Gene Therapy Using Autologous Mesenchymal Stem Cell and Mesenchymal Stem Cell Lyophilisate

Conditions
-----------------
Primary Ovarian Insufficiency, Premature Ovarian Failure

Intervention / Treatment
-----------------
* Other: Observational


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Provision of written informed consent for this study by subjects or as applicable parent legal guardian. Treated with drug product for therapy of premature ovarian insufficiency in a Institute Bio-Stem Cell Rehabilitation UAB clinical study. Diagnosed of premature ovarian insufficiency ESHRE: Women age of 18 to 40 years Have experienced 4 months of oligo/amenorrhea Two serum follicle-stimulating hormone (FSH was >40 mIU/ml levels in the menopausal range, obtained at least a month apart lower FSH levels ( 25 mIU/ml) anti-Müllerian hormone (AMH) serum levels ( 3.0 ng/ml) Exclusion Criteria: There are no exclusion criteria for this study

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
Female

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Observational|Product in a Institute of Bio-Stem Cell rehabilitation UAB - sponsored clinical trial who agree to participate in this study|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Antral follicular count (AFC) serum levels | Antral follicular count (AFC) <5-7 follicles | 2 years | 
| anti-Müllerian hormone (AMH) serum levels | AMH <0.5-1.1 ng/ml | 2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Regular menstruation and/or pregnancy | regular menstruation for 5 months and\or pregnancy | 2 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Premature ovarian failure, stem cell therapy, mesenchymal stem cell