High Intensity Interval Training (HIT) in Patients With Type 2 Diabetes

Study Overview
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Brief Summary
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The purpose of this study is to determine the effect of High Intensity Interval Training (HIT) on insulin sensitivity in skeletal muscle in patients with type 2 diabetes.

Detailed Description
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Physical exercise increases insulin sensitivity in skeletal muscle in healthy as well as in individuals with type 2 diabetes, but implies a considerable time commitment. High intensity interval training (HIT) is time-efficient exercise consisting of repeated bouts of short duration high intensive workloads. The aim of this study is to determine the effect of HIT in patients with type 2 diabetes, and to clarify the mechanisms of a possible positive effect of HIT. Exercise is performed as 2 weeks one-legged training on an ergometer bicycle. Thus one leg serves as a control leg. Insulin sensitivity in trained and non-trained muscle will be measured after completion of the overall training program by euglycemic hyperinsulinemic clamp method and a-v catheterization of both legs. Muscle biopsies will be obtained during training period for measuring of muscle glycogen content, and muscle biopsies for further analysis obtained during the experimental day.

Official Title
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Effect of High Intensity Interval Training (HIT) on Insulin Sensitivity in Patients With Type 2 Diabetes

Conditions
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Type 2 Diabetes

Intervention / Treatment
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* Behavioral: High intensity interval training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 10 subjects with Type 2 diabetes. 10 healthy control subjects. BMI 28-35 diet or tablet treatment for diabetes Exclusion Criteria: regular physical activity diseases other than type 2 diabetes insulin treatment

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: HIT (trained leg) DM<br>High intensity interval training for one leg (trained leg) (randomized) in patient with type 2 diabetes | Behavioral: High intensity interval training<br>* HIT will be conducted as 2 weeks of one legged high intense interval training (8 sessions every 2nd day). Each training session will consist of 10 x 1 min intervals on ergometer bicycle interspersed with 1 min recovery.<br>* Other names: HIIT;|
| No Intervention: Control leg, DM<br>Control leg (untrained leg)in patient with type 2 diabetes | |
| Experimental: HIT (trained leg), Control subject<br>High intensity interval training for one leg (trained leg) (randomized) in control subject | Behavioral: High intensity interval training<br>* HIT will be conducted as 2 weeks of one legged high intense interval training (8 sessions every 2nd day). Each training session will consist of 10 x 1 min intervals on ergometer bicycle interspersed with 1 min recovery.<br>* Other names: HIIT;|
| No Intervention: Control leg, Control subject<br>Control leg (untrained leg)in control subject | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Insulin sensitivity | Insulin sensitivity in trained and non-trained muscle will be measured by euglycemic hyperinsulinemic clamp method and a-v catheterization of both legs. | 2 days after last training session (day 17) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Type 2 diabetes, Insulin sensitivity, High intensity interval training