Concomitant Infection of Intestinal Parasites and Helicobacter Pylori

Study Overview
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Brief Summary
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Intestinal parasitic infections such as Giardia lamblia, Entamoeba histolyica and Enterobius Vermicularis are among the most common infections worldwide.So parasitic infections are considered one of the major health problems in the world especially in developing countries. Helicobacter pylori is a gram-negative,helical-shaped,motile bacillus bacterium,which colonizes the gastric mucosa. H.pylori bacterium secretes urease,a special enzyme that converts urea to ammonia. Ammonia reduces the stomach's acidity .This risk factor allows pathogenic intestinal protozoa such as G.lamblia to take the opportunity to cross through the stomach's increased pH and cause disease.

Official Title
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Concomitant Infection of Intestinal Parasites and Helicobacter Pylori in Sohag University Hospital

Conditions
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Dyspepsia Abdominal Burning Pain Diarrhea Dysentery

Intervention / Treatment
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* Diagnostic Test: H.pylori stool antigen rapid test and stool parasitological examination


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients complaining of dyspepsia , abdominal burning pain,diarrhea,dysentery,of persons of any age or sex group. Exclusion Criteria: patients taking antibiotics within the previous four weeks, proton pump inhibitors within the previous two weeks, or anti-parasitic drugs within the previous two weeks.

Ages Eligible for Study
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Minimum Age: 1 Year

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| A<br>100 positive stool samples for H.pylori | Diagnostic Test: H.pylori stool antigen rapid test and stool parasitological examination<br>* 200 stool samples ( 100 positive and 100 negative for H.pylori) after performance of H.pylori stool rapid antigen test then parasitological stool examination will be done<br>|
| B<br>100 negative stool samples for H.pylori | Diagnostic Test: H.pylori stool antigen rapid test and stool parasitological examination<br>* 200 stool samples ( 100 positive and 100 negative for H.pylori) after performance of H.pylori stool rapid antigen test then parasitological stool examination will be done<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Compare the prevalence of intestinal parasitic infections among positive and negative H.pylori infected outpatients in Sohag University Hospital | Collection of 200 stool samples (100 positive and 100 negative for H.pylori) then parasitological examination done for all samples | 18 weeks following the start point of the study | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluate the prevalence of intestinal parasitic infection among H.pylori infected outpatients in Sohag University Hospital | Macroscopic and microscopic examination of 100 positive H.pylori stool samples | 18 weeks following the start point of the study | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Helicobacter pylori Intestinal Parasites