Volume Controlled Ventilation vs Autoflow-volume Controlled Ventilation

Study Overview
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Brief Summary
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Volume controlled ventilation(VCV) is a most common used ventilation mode during general anesthesia. But VCV can cause high airway peak pressure when patient under steep Trendelenberg position with pneumoperitoneum. Autoflow-VCV can reduce airway peak pressure and improve dynamic compliance. We will compare parameters(arterial blood gas analysis, airway compliance, etc) when each group applied VCV and autoflow-VCV during RALP.

Detailed Description
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Robot assisted laparoscopic radical prostatectomy(RALP) has been used to treatment of prostate cancer since 2001. RALP offers some advantage such as reduced blood loss, sparing nerves, less postoperative pain. However, RALP require steep Trendelenberg position with pneumoperitoneum. It can cause increased airway peak pressure and unwanted hemodynamic effect under conventional volume controlled ventilation(VCV). Autoflow-VCV use decelerating flow, can reduce airway peak pressure and improve dynamic compliance. We will compare parameters(arterial blood gas analysis, airway compliance, etc) when each group applied VCV and autoflow-VCV during RALP.

Official Title
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Comparison of Volume Controlled Ventilation(VCV) vs Autoflow-volume Controlled Ventilation(Autoflow-VCV) During Robot-assisted Laparoscopic Radical Prostatectomy

Conditions
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Prostate Cancer

Intervention / Treatment
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* Device: volume controlled ventilation
* Device: autoflow-volume controlled ventilation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adult (age 19-65) American Society of Anesthesiology Classification I-III Exclusion Criteria: cardiovascular disease, cerebrovascular disease, pulmonary disease over BMI 30

Ages Eligible for Study
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Minimum Age: 19 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: volume controlled ventilation<br>Randomized 23 patients will be applied VCV during RALP. | Device: volume controlled ventilation<br>* After induction of anesthesia and intubation, patients will be applied VCV by Zeus®(Dräger, Germany). - Tidal volume : 8ml/kg(ieal body weight), inspiration:expiration ratio = 1:2, FiO2 = 0.5, fresh gas flow = 3L/min respiratory rate(RR) : 12/min. After position, RR can changed 2 times each per 5 minutes to maintain end tidal CO2 around 35. Positive end expiratory pressure will not used.<br>|
| Active Comparator: autoflow-volume controlled ventilation<br>Randomized 23 patients will be applied autoflow-VCV during RALP. | Device: autoflow-volume controlled ventilation<br>* After induction of anesthesia and intubation, patients will be applied autoflow- VCV by Zeus®(Dräger, Germany). - Tidal volume : 8ml/kg(ideal body weight), inspiration:expiration ratio = 1:2, FiO2 = 0.5, fresh gas flow = 3L/min respiratory rate(RR) : 12/min. After position, RR can changed 2 times each per 5 minutes to maintain end tidal CO2 around 35. Positive end expiratory pressure will not used.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Airway pressure | Airway pressure will be measured under specified ventilation mode. | 4hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Vital sign | Vital sign will be measured under specified ventilation mode. | 4hours |