Short-term Sugary Beverage Consumption on Glucose Control and Cardiovascular Disease Risk Factors

Study Overview
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Brief Summary
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Our goal is to determine how the addition of sugar-sweetened beverages to the diet affects glucose control, cardiovascular disease risk factors, and pulmonary function in healthy, young adults.

Detailed Description
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In a 3-arm randomized controlled trial, 36 participants consumed one of three beverages for three weeks: water (W), caffeine-free soda (S), or 100% fruit juice (FJ). Participants consumed two servings/day ( 710mL) of their randomized beverage for three weeks, along with their habitual diets. At baseline and following the 3-week intervention, participants completed glucose control, cardiovascular disease risk factor, and pulmonary function assessments.

Official Title
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Effects of Short-term Sugary Beverage Consumption on Type-2 Diabetes and Cardiovascular Disease Risk Factors: A Randomized Controlled Trial

Conditions
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Metabolic Syndrome

Intervention / Treatment
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* Dietary Supplement: Sugary beverage: Fruit juice
* Dietary Supplement: Sugary beverage: Soda
* Dietary Supplement: Control: Water


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Free from diagnosis of diabetes and pulmonary illness Have no intake of glucose or lipid lowering medication. Exclusion Criteria: Smoke Currently pregnant Have bronchitis Have more than 2 risk factors for cardiovascular disease, as defined by the American College of Sports Medicine (ACSM).

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 30 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Fruit Juice<br>Participants consumed 2 bottles of 100% fruit juice daily for 3 weeks. | Dietary Supplement: Sugary beverage: Fruit juice<br>* Participants consumed 100% fruit juice ( 710mL) daily for three weeks, along with their habitual diets.<br>|
| Experimental: Soda<br>Participants consumed 2 cans of caffeine-free Coca Cola daily for 3 weeks. | Dietary Supplement: Sugary beverage: Soda<br>* Participants consumed soda ( 710mL) daily for three weeks, along with their habitual diets.<br>|
| Other: Water<br>Participants consumed 2 bottles of water daily for 3 weeks. | Dietary Supplement: Control: Water<br>* Participants consumed water ( 710mL) daily for three weeks, along with their habitual diets.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in glucose iAUC | Glucose obtained from blood sample in a fasted state and in response to a meal | Week 0 and Week 3 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in plasma lipids | Total cholesterol (TC), LDL-c , VLDL-c, HDL-c , triglycerides (TG) from blood sample in a fasted state and following consumption of a meal | Week 0 and Week 3 | 
| Change in homeostatic model assessment for insulin resistance | Calculated from fasting glucose and insulin values | Week 0 and Week 3 | 
| Change in blood pressure | Evaluated via automated sphygmomanometer. | Week 0 and Week 3 | 
| Change in BMI | Weight and height will be combined to report BMI in kg/m^2 | Week 0 and Week 3 | 
| Change in pulmonary function | Assessed using the maximum flow-volume loop | Week 0 and Week 3 | 
| Change in insulin iAUC | Glucose obtained from blood sample in a fasted state and in response to a meal | Week 0 and Week 3 | 
| Change in serum fructosamine | Fructosamine obtained from blood sample | Week 0 and Week 3 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Glucose control, Cardiovascular disease risk factors, Sugary beverages, Pulmonary function