NEWS and Rapid Lactate Testing for Early Identification of High Risk Patients in the Emergency Department

Study Overview
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Brief Summary
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To validate the NEWS and rapid lactate testing for early identification of high risk [triage Category 3 (urgent)] patients in the Emergency Department. To compare qSOFA and SIRS criteria in patients in the Emergency Department.

Detailed Description
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Background: Sepsis is a potentially life-threatening complication of an infection. Early identification and early intervention are two main elements in improving patient care. Objectives: To validate the NEWS and rapid lactate testing for early identification of high risk [triage Category 3 (urgent)] patients in the Emergency Department. To compare qSOFA and SIRS criteria in patients in the Emergency Department. Study design: This is a prospective, cohort study. Patients aged 18 or above presenting to the ED triaged as Category 3 (urgent) will be recruited. The required data for calculating NEWS will be collected at triage and triage lactate level will be measured by point-of-care analyzer. Outcomes: The primary outcome is referral for intensive care unit (ICU) admission during the patient's ED stay. The secondary outcomes are length of stay in hospital (LOS), hospital admission, admission to ICU, length of ICU-free admission (defined as days alive outside the ICU from admission to day 30) 30-day mortality and time to processes-of-care.

Official Title
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Validation of National Early Warning Score (NEWS) and Rapid Lactate Testing for Early Identification of High Risk Patients in the Emergency Department

Conditions
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Triage Category 3 (Urgent)

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Aged 18 years or above who are triage category 3 in emergency department Presenting to emergency department between 9am and 4pm, Monday to Friday Exclusion Criteria: Aged below 18 years Pregnant

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 30-day mortality |  | 30 days after recruitment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| referral for intensive care unit (ICU) admission |  | 24 hr after recruitment | 
| length of stay in hospital (LOS) |  | 30 days after recruitment | 
| hospital admission |  | 30 days after recruitment | 
| admission to ICU |  | 30 days after recruitment | 
| length of ICU-free admission |  | 30 days after recruitment | 
| time to processes-of-care | time to lactate measured, time to antibiotics admission, time to blood culture obtained, time to fluid resuscitation, time to vasopressor administration from ED arrival | 24 hr after recruitment | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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National Early Warning Score (NEWS), Lactate, Emergency Department