Study Of Factors Favoring The Onset Of Novo Atrial Fibrillation In The Immediate Aftermath Of Coronary Artery Bypass Surgery

Study Overview
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Brief Summary
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Before la surgery: Transthoracic cardiac echography will be done systematically, to measure among other things the size of the left atrium. During surgery: Surgery under extracorporeal circulation: tissue samples will be harvested from the right atrium (one before clamping of the aorta (T0= pre-ischemia sample), immediately before declamping of the aorta (T1= post-ischemia sample). Surgery without extracorporeal circulation: tissue samples from the right atrium before CABG (T0) and a second sample after CABG (T1). In parallel with the harvesting of cardiac tissue, blood samples will be taken at different times (H0, H3, H24) to correlate tissue data with systemic data. These will be taken by the anesthetists. After the surgery: Holter ECG will be set up for 7 days of continuous recording. Each patient will fill in an observation notebook. The biological samples will be analysed immediately and the biological data obtained will be recorded in the observation notebook.

Official Title
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STUDY OF FACTORS FAVORING THE ONSET OF NOVO ATRIAL FIBRILLATION IN THE IMMEDIATE AFTERMATH OF CORONARY ARTERY BYPASS SURGERY

Conditions
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Coronary Artery Bypass Graft With or Without ECC

Intervention / Treatment
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* Other: Tissue samples from the right atrium
* Other: Blood samples


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients who have provided written informed consent Patients covered by the national health insurance scheme Heart surgery (CABG) with and without extracorporeal circulation Elective or deferred emergency surgery Consecutive patients aged less than 80 years Exclusion Criteria: Patients less than 18, under guardianship Patients over 18, under guardianship Patients who do not understand the study data Patients undergoing emergency surgery who therefore cannot be given or understand the explanations for the study (patients in shock, intubated patients with mechanical ventilation) History of heart surgery History of AF Treatment with Cordarone.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 79 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients about to undergo heart surgery<br> | Other: Tissue samples from the right atrium<br> <br> Other: Blood samples<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Onset or a de novo episode of atrial fibrillation during the 7 days following heart surgery |  | 7 days post-surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Markers of ischemia: circulating Troponin I before the surgery and at the end of the procedure |  | Baseline and at the end of surgery (15 minutes after unclamping when extracorporeal circulation) |