Study of Attentional Disorders in Patients Suffering From Idiopathic Generalized Epilepsy.

Study Overview
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Brief Summary
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Attentional disorders have been reported in neuropsychological studies evaluating patients suffering from generalized idiopathic epilepsy, but the data are disparate (in terms of test protocol). We aim to describe attentional and executive function disorder in IGE thanks to the Epitrack scale, validated in this specific population. Our secondary objective is to study the dynamic of cortical activity during an attentional task (the ANT), in order to describe the alteration of cortical networks in epileptic patients presenting with attentional disturbance.

Official Title
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Study of Attentional Disorders in Patients Suffering From Idiopathic Generalized Epilepsy.

Conditions
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Idiopathic Generalized Epilepsy

Intervention / Treatment
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* Other: Neuropsychological screening and high resolution EEG recording


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Idiopathic generalized epilepsy followed-up during at least 2 years At least one antiepileptic drug medication No cognitive decline (MoCA score >26) Absence of concomitant pathology that could interfere with the purpose of the study. Be affiliated to the social security system Have signed an informed consent Exclusion Criteria: Pregnancy Not able to give consent (Article 1121-8 of the CSP) Vulnerable person Being deprived of liberty by judicial or administrative decision (Article L 1121-6 of the CSP) Have a high probability of not respecting the protocol or of abandoning the study

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with idiopathic generalised epilepsy<br> | Other: Neuropsychological screening and high resolution EEG recording<br>* Each participant will be assessed with a battery of neuropsychological tests including Epitrack, the Raven's progressive matrice, the MoCA, the D2-R test, the BDI-II test, the STAI and the Qolie-31. Then, a prolonged EEG recording at rest and during an attentional task (the ANT) will be realized<br>|
| healthy controls<br>age- and sex-matched healthy controls | Other: Neuropsychological screening and high resolution EEG recording<br>* Each participant will be assessed with a battery of neuropsychological tests including Epitrack, the Raven's progressive matrice, the MoCA, the D2-R test, the BDI-II test, the STAI and the Qolie-31. Then, a prolonged EEG recording at rest and during an attentional task (the ANT) will be realized<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Epitrack scale score | EPITrack-Score shows the performance of attention and executive functions. Higher values indicate a better performance. scale from 9-49 (9 worst score - 49 best score) | At 1 month after inclusion | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Raven's progressive matrice scores | cortical source connectivity patterns. | At 1 month after inclusion | 
| Montreal Cognitive Assessment (MoCA) score | Cognitive function was assessed by using MoCA score. Cognitive impairment was considered present when MoCA scores were <26 . | At 1 month after inclusion | 
| D2-R test score | cortical source connectivity patterns. | At 1 month after inclusion | 
| BDI-II score | Anxiety-depressive symptoms score Beck Depressive Inventory Questionnaire (BDI-II) (score), higher scores mean worse outcome, value minimum of 0 maximum 63 | At 1 month after inclusion | 
| STAI scale | Anxiety-depressive symptoms score The State-Trait Anxiety Inventory (STAI) is a self-questionnaire, 20 questions, a score is calculated, ranging from 20 to 80, a high score indicating the presence of anxiety. | At 1 month after inclusion | 
| quality of life using the Qolie-31 self questionnaire | Quality Of Life In Epilepsy-Problems questionnaire (QOLIE31-P) questionnaire has been developed specifically to measure the quality of life of patients with epilepsy. The score ranges from 0 to 100 points. Higher scores reflect better quality of life; lower ones, worse quality of life. | At 1 month after inclusion | 
| High resolution Electro Encephalo Gram functional connectivity markers at rest and during the ANT task | limited number of reproducible resting activity patterns, brain networks involved in the absence of task performance | At 1 month after inclusion | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Attention, Epilepsy, Connectivity, EEG