Real World Assessment of Effects of Beta-blockers on Patients With Acute Coronary Syndrome

Study Overview
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Brief Summary
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The study is aimed to optimized the dose-adjusted regimen of beta-blockers in patients with acute coronary syndrome by investigating therapeutic and curative results of target doses Beta-blockers using the dose-adjusted pathway of beta-blockers.

Official Title
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Real World Assessment of Effects of Beta-blockers on Patients With Acute Coronary

Conditions
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Acute Coronary Syndrome

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age ≥ 18 years Patients diagnosed as acute coronary syndromes including acute ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevated acute coronary syndrome (NSTE-ACS) Patients or whose legal representatives signed written informed consent form Exclusion Criteria: Patients should been excluded if they meet any of the following exclusion criteria: Patients with contraindications to the application of beta blockers, including: 1) cardiogenic shock or heart failure (Killip grade > II level);2) sick sinus syndrome; 3) II degree atrioventricular block;4) unstable decompensation of cardiac failure (pulmonary edema, hypotension or low perfusion); 5) symptomatic hypotension or bradycardia (heart rate<50 beats/min, blood pressure<90/60mmHg); 6) contraindications to beta blockers or allergy to any ingredient of beta blocker; 7) active asthma should be treated by inhalation preparation treatment Pregnant or lactating women Patients without signed written informed consent Patients who was considered by the researcher inappropriate to participate in this study (for example, patients with a higher risk of cardiogenic shock, etc.)

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 120 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Major adverse cardiovascular and cerebrovascular events (MACCE) | MACCE were defined as a composite of all-cause death, myocardial infarction (MI), unplanned target vessel revascularization (TVR), stent thrombosis (ST) and stroke. | Within 1 year after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Resting heart rate | The resting heart rate of the body is the number of contractions of the heart that occur in a single minute while the body is at complete rest. | Within 1 year after surgery | 
| Blood pressure (systolic & diastolic) | Blood pressure (BP) is the pressure of circulating blood on the walls of blood vessels. | Within 1 year after surgery | 
| Ejection fraction | Ejection fraction (EF) is the volumetric fraction of fluid (usually blood) ejected from a chamber (usually the heart) with each contraction (or heartbeat). | Within 1 year after surgery | 
| Serum norepinephrine | Norepinephrine is a neurotransmitter that is secreted in response to stress. | Within 1 year after surgery |