Text Education About Cardiovascular Health and HIV (TEACH-HIV)

Study Overview
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Brief Summary
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The overall objective is to evaluate the efficacy of educational text messages to reduce cardiovascular risk among persons living with HIV (PLWH).

Official Title
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Text Education About Cardiovascular Health and HIV (TEACH-HIV)

Conditions
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HIV, Human Immunodeficiency Virus, Cardiovascular Diseases, Atherosclerosis

Intervention / Treatment
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* Behavioral: Digital Educational Messaging


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: HIV positive At least 40 years of age English-speaking Exclusion Criteria: Existing clinical atherosclerotic cardiovascular disease (ASCVD) Pregnant Unwilling/unable to provide informed consent Does not own a smartphone

Ages Eligible for Study
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Minimum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Intervention Arm<br>The intervention arm will receive education about HIV and heart disease risk via mobile phone text messages for up to 6 months. They will receive the text messages 3-5 times per week. The messages will include information about HIV and risk of heart disease and information about how to reduce heart disease risk. The intervention arm will also receive brief monthly surveys via a digital research platform. | Behavioral: Digital Educational Messaging<br>* Education via mobile phone text messages for up to 6 months.<br>|
| No Intervention: Control Arm<br>The control arm will not receive the educational text messages. They will receive brief monthly surveys via a digital research platform. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Proportion of participants with controlled blood pressure | Proportion of participants with blood pressure < 130/80 mmHg as recorded in the electronic health record (EHR). | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of cardiovascular risk factors controlled | Total of 8 risk factors: diet, physical activity, nicotine exposure, sleep health, body mass index, blood lipids, blood glucose, blood pressure. Risk factors will be assessed using self-report and EHR data. Risk factor control will be defined based on the American Heart Association's (AHA) Life's Essential 8. | 6 months | 
| Self-perceived cardiovascular risk | Measured by self-report using questions adapted from the patient and provider assessment of lipid management (PALM) registry. | 6 months | 
| Systolic blood pressure | Evaluated using EHR data. | 6 months | 
| Cholesterol | Non-HDL cholesterol, total cholesterol, LDL cholesterol (in mg/dL), as evaluated using EHR data. | 6 months | 
| Physical activity | Minutes/week, measured via self-report using the International Physical Activity Questionnaire (IPAQ). | 6 months | 
| Physical activity | Measured via step count. | 6 months | 
| Mediterranean diet | Measured using the Mediterranean Eating Pattern for Americans (MEPA) tool, as scored by AHA's Life's Essential 8. Score ranges 0-16, with higher scores representing better outcomes. | 6 months | 
| Proportion of current smokers | Measured via self-report. | 6 months | 
| Blood sugar control | Evaluated using EHR data on hemoglobin A1c and fasting blood glucose. Blood sugar control will be defined based on the AHA's Life's Essential 8 definitions. | 6 months | 
| Body mass index | Evaluated in kg/m2 using EHR data. | 6 months | 
| Proportion of patients on guideline-based therapy | Proportion of patients on anti-hypertensive medications, statins, and aspirin, among those who meet criteria for therapy based on American Heart Association / American College of Cardiology (AHA/ACC) guidelines. | 6 months |