Effects of Physical-Cognitive Training With Different Task Models in Parkinson's Disease With Mild Cognitive Impairment

Study Overview
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Brief Summary
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The present study will characterize exercise model effects (integrated model vs. consecutive model) of physical-cognitive exercise on dual-task walking control in Parkinson's disease with mild cognitive impairment.

Official Title
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Effects of Physical-Cognitive Training With Different Task Models on Dual-Task Walking in Parkinson's Disease With Mild Cognitive Impairment

Conditions
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Mild Cognitive Impairment, Parkinson Disease

Intervention / Treatment
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* Behavioral: Integrated physical-cognitive training
* Behavioral: Consecutive physical-cognitive training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: a diagnosis of idiopathic Parkinson's disease have decreased cognitive functions but do not interfere with functional independence Montreal Cognitive Assessment (MoCA): 21-25 able to walk independently without walking devices for at least 10 meters and with the ability to turn 180° Exclusion Criteria: a diagnosis of dementia other diseases that may influence cognitive functions or walking performance a history of brain surgery modification of the medication during the exercise intervention

Ages Eligible for Study
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Minimum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Integrated training model<br>Participants in this group will accept postural and cognitive training at the same time, e.g. naming animals while standing on the foam. Each training session will last for 70 minutes, twice a week, and 12 sessions in total. | Behavioral: Integrated physical-cognitive training<br>* Perform a postural task and a cognitive task at the same time (dual-task model) 70 minutes/session*2 sessions/week*6 weeks<br>|
| Experimental: Consecutive training model<br>Participants in this group will accept postural and cognitive training separately and for identical durations (both 30 minutes). Each training session will last for 70 minutes, twice a week, and 12 sessions in total. | Behavioral: Consecutive physical-cognitive training<br>* Perform a postural task and a cognitive task separately for identical durations 70 minutes/session*2 sessions/week*6 weeks<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from baseline dual-task walking performance at 8 weeks |  | 8 weeks | 
| Fall frequency |  | 20 weeks | 
| Change from baseline Montreal Cognitive Assessment (MoCA) score at 8 weeks | MoCA: 0-30 points, higher scores mean a better outcome | 8 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Dual-task walking training, Parkinson's disease, Mild cognitive impairment, Electroencephalography