The Effect of Adenomoyosis on Pregnancy Outcomes

Study Overview
=================
Brief Summary
-----------------
Adenomyosis can be defined as the settling of endometrial gland cells in the myometrium and deformity in the uterus and the prevalence of adenomyosis is according to the patient population and countries around 20%. There are recent publications reporting that this rate increases up to 50% in women dealing with infertility. In adenomyosis, where uterine morphology is affected, it is not thought that the uterus, which is expected to provide many morphological adaptations during pregnancy, will not be affected. Therefore, in this prospective study, it was planned to investigate the effects of adenomyosis during pregnancy. For this study the presence of adenomyosis will be questioned by using ultrasonographic morphological uterine limitation (MUSA) in women who apply to the outpatient clinic with suspicion of pregnancy and undergo transvaginal ultrasonography for the diagnosis of pregnancy before sixth gestational week. Patients will be divided into two groups according to the presence of adenomyosis and pregnancy complications such as preterm labor, premature rupture of membranes, cesarean section rates, preeclampsia, fetal malpresentation and preeclampsia will be compared between the groups.

Official Title
-----------------
Adverse Obstetrical Outcomes for Women With Adenomyosis

Conditions
-----------------
Adenomyosis, Pregnancy Complications

Intervention / Treatment
-----------------
* Other: Non intervention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age between 18-35 years Being diagnosed before the 6th gestational week Having all pregnancy follow-ups and deliveries in our hospital Exclusion Criteria: Previous uterine surgery Multiple pregnancies Pregnant women with uterine malformations Pregnant women with fetal anomalies Those who got pregnant using assisted reproductive technique

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Adenomyosis Group<br> | Other: Non intervention<br>* During the study there is no extra intervention planned for the participants.<br>|
| Non-adenomyosis Group<br> | Other: Non intervention<br>* During the study there is no extra intervention planned for the participants.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pregnancy complication | Preterm labour | 15 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pregnancy complication | placental anomalies | 16 month | 
| Pregnancy complication | preeclampsia, eclampsia | 17 month | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
adenomyosis, pregnancy complications, MUSA classification, ultrasound