Corneal Endothelial Cell Changes After Phacoemulsification in Patients With Type 2 Diabetes Mellitus

Study Overview
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Brief Summary
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This study investigate the change of the corneal endothelial cells in patients with type 2 diabetes after phacoemulsification with intraocular lens implantation.

Detailed Description
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The investigators do the clinical prospective study including 30 patients with type 2 diabetes and 30 control patients without diabetes scheduled to undergo cataract surgery. The corneal endothelial cell density, variation in endothelial cell size (CV), percentage of hexagonal cells, and central corneal thickness(CCT) were recorded at baseline and at 3 months postoperatively.Then, the investigators compared the two sets of data. At last observing the change of the corneal endothelial cells in patients with type 2 diabetes after phacoemulsification with intraocular lens implantation.

Official Title
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白内障超声乳化术对2型糖尿病患者角膜内皮细胞的影响 Corneal Endothelial Cell Changes After Phacoemulsification in Patients With Type 2 Diabetes Mellitus

Conditions
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Cataract, Diabetes Mellitus

Intervention / Treatment
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* Other: specular microscope


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: the experimental group: Clinical diagnosis of cataract Type 2 diabetes mellitus The recent blood glucose control was stable The glycosylated hemoglobin < 8% The control group: Clinical diagnosis of cataract No history of type 2 diabetes Exclusion Criteria: Corneal lesions Anterior inflammation Ocular trauma or surgical history Glaucoma Corneal endothelial cell density < 1500 / mm squared

Ages Eligible for Study
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Minimum Age: 58 Years
Maximum Age: 86 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| the diabetic group<br>patients with type 2 diabetes scheduled to undergo cataract surgery | Other: specular microscope<br>* The corneal endothelial cell density, variation in endothelial cell size (CV), percentage of hexagonal cells, and central corneal thickness(CCT) were recorded at baseline and at 3 months postoperatively.<br>|
| the control group<br>patients without diabetes scheduled to undergo cataract surgery | Other: specular microscope<br>* The corneal endothelial cell density, variation in endothelial cell size (CV), percentage of hexagonal cells, and central corneal thickness(CCT) were recorded at baseline and at 3 months postoperatively.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of the corneal endothelial cell density before-after cataract surgery | Comparison of the corneal endothelial cell density before-after cataract surgery，the density is expressed in terms of the number of cells per square millimeter. | half year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of the endothelial cell size before-after cataract surgery | Comparison of the endothelial cell size before-after cataract surgery，the size is measured in square microns. | half year | 
| Comparison of the percentage of hexagonal cells before-after cataract surgery | Comparison of the percentage of hexagonal cells before-after cataract surgery,the percentage are expressed as %. | half year | 
| Comparison of the central corneal thickness(CCT) before-after cataract surgery | Comparison of the central corneal thickness(CCT) before-after cataract surgery，the thickness is in microns. | half year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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type 2 diabetes mellitus, cataract, phacoemulsification, corneal endothelial cells