Krill Oil as Supplementation to Healthy Young Adults.

Study Overview
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Brief Summary
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The purpose of this study is to examine whether 4 weeks daily intake of krill oil can change the omega-3 index (content of the long chained fatty acids EPA and DHA in relation to the total fatty acids) in the membrane in red blood cells. We investigate this at two different doses. Furthermore, the purpose of the study is also to examine the effect of the krill oil intake on plasma lipids (triacylglycerol, phospholipids and cholesterol), plasma fatty acid composition, as well as product tolerance in healthy, young individuals.

Official Title
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Study of the Effect of Krill Oil Supplement on Omega-3 Fatty Acid Index and Tolerance

Conditions
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Healthy

Intervention / Treatment
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* Dietary Supplement: Krill oil low dose
* Dietary Supplement: Krill oil high dose


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy young adults Exclusion Criteria: Disease/illness Not able to swallow supplements in capsule form Not willing to take blood samples

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 36 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Krill oil low dose<br>3 capsules krill oil per day, for 28 days | Dietary Supplement: Krill oil low dose<br>* 3 capsules krill oil per day<br>* Other names: Rimfrost Sublime krill oil;|
| Experimental: Krill oil high dose<br>9 capsules krill oil per day, for 28 days | Dietary Supplement: Krill oil high dose<br>* 9 capsules krill oil per day<br>* Other names: Rimfrost Sublime krill oil;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fatty acid composition in red blood cells (the membrane) | Change in fatty acid composition and omega-3 index (sum of % EPA and DHA) | Day 0 (baseline), and day 28 (end) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fasting plasma lipid status | Change in triacylglycerol levels. Change in phospholipid levels. Change in cholesterol levels (total, ester, free, HDL, LDL). | Day o (baseline), and day 28 (end) | 
| Fatty acid composition in plasma. | Change in fatty acid composition and omega-3 index (sum of % EPA and DHA). | Day 0 (baseline), and day 28 (end) | 
| Fasting glucose and glucose tolerance. | Change in fasting glucose and glucose tolerance. | Day 0 (baseline), and day 28 (end) | 
| Tolerance of and compliance with intervention | Questionnaire-based | Day 28 (end) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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tolerance, krill oil, omega-3 index, plasma lipid profile, young adults