Predictive Biomarkers of Secondary Aggravation in Covid-19 Suspect Patient

Study Overview
=================
Brief Summary
-----------------
There is no predictive tool for patients admitted to the emergency department with a suspicion of Covid-19 that will worsen secondarily and require a heavy lifting. In a context of saturation of the healthcare system by the pandemic at Covid-19,it is essential to identify specific, accessible prognostic markers via minimally invasive sampling with low risk of infection for personnel caregiver, for optimal allocation of resuscitation resources. This study proposes to evaluate the biological markers of routine care known to be associated with resuscitation admission in relation to hospitalization on conventional service for the prediction of worsening of patients admitted to the emergencies for Covid-19.

Official Title
-----------------
Predictive Biomarkers of Secondary Aggravation in Covid-19 Suspect Patient Admitted to Emergency Departments During an Epidemic

Conditions
-----------------
Infection Viral, Coronavirus, COVID-19

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Clinical criteria for suspicion of Covid-19 in an epidemic period Consultation in the emergency departement Non-opposition agree Exclusion Criteria: impairment related to another identified cause than Covid-19, in particular a rapid diagnostic test flu-positive Severe patient from the outset with transfer to intensive care within 12 hours of admission to the Emergency Department No social security coverage (beneficiary or entitled person) Poor understanding of French Refusal to participate

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of secondary aggravation | Secondary aggravation is defined as : a re-hospitalization or aggravation in hospitalization : development or increase in oxygen dependency, hemodynamic failure, and/or respiratory, death | an average at 30 days (- 2 days +3 days) of admission to the emergency department | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of standart biological parameters | the number of leukocytes, lymphocytes, neutrophil polynuclear cells, CRP, fibrinogen, and the D-dimers. | Between baseline and an average at 30 days (- 2 days +3 days) of admission to the emergency department | 
| Change of Von willebrand factor (vWF) changes over time |  | Between baseline and an average at 30 days (- 2 days +3 days) of admission to the emergency department | 
| Change of the Factor VIII (FVIII) |  | Between baseline and an average at 30 days (- 2 days +3 days) of admission to the emergency department | 
| Prevalence of positivity of COVID-19 virus measured by PCR or serology |  | an average at 30 days (- 2 days +3 days) of admission to the emergency department | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
infection viral, biological risk factor, coronavirus, covid-19