Subthalamic Nucleus Connectivity in Parkinson's Disease With Ultra-high Field Magnetic Resonance Imaging

Study Overview
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Brief Summary
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The purpose of this study is to investigate the segregation of the subthalamic nucleus into its motor and non-motor regions in patients with Parkinson's disease and healthy controls with the aid of ultra-high field magnetic resonance imaging.

Official Title
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Ultra-high Field Imaging of the Cortico-striato-subthalamic Functional and Structural Connectivity to Improve Deep Brain Stimulation Surgery in Parkinson's Disease Patients

Conditions
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Parkinson Disease

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Both groups: Mental competence Group 1: Parkinson's disease patients scheduled for deep brain stimulation surgery Group 2: Age and gender matched volunteers Exclusion Criteria: Both groups: Head injury Stroke Other neurological diseases other than Parkinson's disease Metallic prostheses or pacemaker in the subject's body or other contra indications for MRI Group 1: Inability to abstain from dopaminergic drug use Group 2: Parkinson's disease Use of medication affecting the central nervous system

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with Parkinson's Disease<br> | |
| Healthy volunteers<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Voxels of the subthalamic nucleus that are structurally or functionally connected to the motor cortex. | Two brain areas are said to be structurally connected if they are connected by fiber tracks computed from diffusion weighted MRI data. Two brain areas are said to be functionally connected if they show statistically significantly correlated resting state functional MRI signals. | One measurement, consisting of 1 MRI scan of 1 hour | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Strength of the structural and functional connectivity between the subthalamic nucleus and the motor cortex. | Strength of the structural connectivity is defined as: fractional anisotropy along computed fiber tracks between the subthalamic nucleus and the motor cortex. Strength of the functional connectivity is defined as: height of the correlation between the resting state functional MRI signals in the subthalamic nucleus and the motor cortex. | One measurement, consisting of 1 MRI scan of 1 hour | 
| Brain areas structurally and functionally connected to the stimulation zone of the optimal electrode of operated Parkinson's patients. | This results in a list with brain structures that are functionally and/or structurally connected to the stimulation zone. | One measurement, consisting of 1 MRI scan of 1 hour | 
| Brain areas that show an activation pattern measured with functional magnetic resonance imaging, that is correlated to a motor task. | This results in a list of brain areas that are related to the motor task. | One measurement, consisting of 1 MRI scan of 1 hour | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Parkinson Disease, Subthalamic Nucleus, Ultrahigh field Magnetic Resonance imaging, Functional connectivity, Structural connectivity