Study on Genetically Affected Sporadic Thoracic Aortic Aneurysm and Dissection

Study Overview
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Brief Summary
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Mortality of thoracic aortic aneurysm and dissection (TAAD) remains high because of the huge blood lost from the aorta. Questions about the potentially genetic effects on sporadic TAAD are raised by researchers to explore the possible mechanisms leading to sporadic TAAD and to establish new clinical approaches to prevent TAAD-caused adverse clinical outcomes. This study is intended to collect the gene information in sporadic TAAD patients and to explore the relationship between genetic variation and the incidence of sporadic TAAD for further study.

Detailed Description
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Thoracic aortic dissection (TAD) is a critical clinical condition partly due to the rupture of aortic aneurysm. Mostly, surgical treatment can reduce the symptoms and extend life span of patients with thoracic aortic aneurysm and dissection (TAAD). However, mortality of TAAD remains high because of the huge blood lost from the aorta. Sporadic TAAD was considered to be a server consequence of hypertension, though most patients with hypertension won't have TAAD as their final outcomes. Previous studies have revealed the associations between genetic abnormalities and familial TAAD, and genetic tests have applied to assist the diagnosis of certain TAAD. Therefore, the potentially genetic effects on sporadic TAAD are explored by researchers to understand the possible mechanisms leading to sporadic TAAD and to establish new clinical approaches to prevent TAAD-caused adverse clinical outcomes. This study is intended to collect the gene information in sporadic TAAD patients and to explore the relationship between genetic variation and the incidence of sporadic TAAD for further study.

Official Title
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Study on Genetically Affected Sporadic Thoracic Aortic Aneurysm and Dissection

Conditions
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Dissection of Aorta, Thoracic, Aneurysm of Aorta, Thoracic

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with thoracic aortic aneurysm and dissection not due to trauma Exclusion Criteria: Inability of the patient, parent or guardian to give consent Unwillingness to provide a blood specimen or participate in the study

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| thoracic aortic aneurysm and dissection<br>Patients with thoracic aortic aneurysm and/or dissection are recruited in the study. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Numbers of patients having thoracic aortic aneurysm and/or dissection are recorded. Diagnosis are confirmed by imaging analysis (CTA and/or Ultrasound) or by doctors during the operations. | Arterial dissection actually happened | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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dissection, aneurysm, thoracic aorta