Myopic Optic Neuropathy in Chinese High Myopia Population

Study Overview
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Brief Summary
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This study intends to establish a registry cohort to enroll patients with high myopia to study the natural course of myopic optic neuropathy in Chinese adult population.

Detailed Description
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Global prevalence of high myopia brings about markedly increasing of blinding complications as myopic optic neuropathy (MON) and glaucoma. It was estimated that there were 163 million people who have high myopia in 2000, and the population with high myopia would increase to almost one billion (9.8% of the world population) worldwide by 2050. Glaucoma is the leading cause of irreversible blindness worldwide while it is difficult to distinguish glaucoma among MON in high myopia eyes. However, there lack longitudinal study to illustrate the natural course interpreting the distribution and natural history of MON. In view of the above problems, this is a longitudinal registry cohort study to observe the long-term changes of structural and functional parameters of MON in high myopia, and to investigate the natural course and associted risk factors that influence the progression in a Chinese adult population.

Official Title
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Natural History of Myopic Optic Neuropathy for High Myopia in Chinese Adult Population: a Registry Cohort Study

Conditions
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Eye Diseases

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria Age ≥18 years Equivalent spherical ≤-6D or axial length ≥26.5mm Best corrected visual acuity ≥ 6/12 Exclusion Criteria Unwilling or unable to give consent, or unable to return for scheduled protocol visits. Glaucoma secondary to penetrating keratoplasty, trauma, steroids, retinal disease/surgery, or neovascular disease. Obvious corneal and iris lesions, or severe cataracts interfering with fundus examinations, VF test or monophthalmia. Need for ocular surgery/laser or anticipated need for cataract surgery during the study period. Other serious systemic diseasesf (i.e. hypertension, heart disease, diabetes, or rheumatic immune system diseases); Pregnant or nursing women

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| high myopia<br>Population who have high myopia. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Progression of glaucoma within 36 months | Structural and functional changes of glaucoma using visual field, stereoscopic fundus photography. | 3 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Progression of myopia and other structural changes of retina and choroid. | Structural and functional changes of myopia based on axial length and refractive error. | 3 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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myopic optic neuropathy, high myopia, glaucoma