Acetazolamide's Headache Inducing Characteristics and Effects on the Cerebral Arteries and Blood Flow

Study Overview
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Brief Summary
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In this study the investigators will research the hypothesis that the drug Acetazolamide induce headache and dilation of cerebral arteries and increase the cerebral blood flow in the areas of the brain supplied by these arteries.

Detailed Description
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To investigate headache score and accompanying symptoms during and after infusion of acetazolamide. With magnetic resonance imaging the investigators will investigate changes in regional cerebral blood flow (rCBF) in the area supplied by middle cerebral artery (MCA), diameter of MCA, the Internal carotic artery (ICA), the superficial temporal artery (STA) and the Medial Meningeal artery (MMA).

Official Title
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Basic Research on Acetazolamide´s Headache Inducing Characteristics and Effects on the Cerebral Arteries and Blood Flow in a Humane Experimental Headache Model

Conditions
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Headache, Migraine

Intervention / Treatment
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* Drug: Acetazolamide


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy volunteers Aged 18-40 50-100 kg Fertile women must use safe contraceptives (IUD, oral contraceptives, surgical sterilisation and long lasting gestagen. Exclusion Criteria: Tension type headache more than once/month Other primary headaches Daily medication except contraceptives Drug taken within 4 times the halflife for the specific drug except contraceptives Pregnant or lactating women Exposure to radiation within the last year Headache within the last 24 hours before start of trial Hypertension Hypotension Respiratory or cardiac disease

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Acetazolamide<br>Acetazolamide 1 g in 10 ml saline, i.v. infusion | Drug: Acetazolamide<br>* 1 g diluted in 10 ml saline, i.v. bolus injection.<br>* Other names: Diamox;|
| Placebo Comparator: Saline<br>Saline, 10 ml i.v. infusion | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Headache scores | Comparison between Acetazolamide and placebo (saline). | 24 h | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Artery circumference | Acetazolamide induced changes in intracranial artery circumference before and after infusions. | Baseline, 30 min and 60 min | 
| Cerebral blood flow | Acetazolamide induced changes in cerebral blood flow. | Baseline, 30 and 60 min. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Acetazolamide, Headache, Migraine