linjc16/ctgov huggingface dataset:
Prognostic Biomarkers of Pancreatic Cancer Based on Proteomics Techniques

Study Overview
=================
Brief Summary
-----------------
In this study, we will use high-throughput proteomics techniques to search for biomarkers of post-operative prognosis of pancreatic cancer in samples of patients who have been diagnosed with pancreatic cancer through bioinformatics analysis.

Detailed Description
-----------------
This study plan from the affiliated hospital of Qingdao university collected 20 cases of patients with pancreatic cancer pathological tissue samples and clinical data, including clinical diagnostic information, laboratory tests, imaging examination results and other information data), through high-throughput proteomic technology in pancreatic cancer pathological finding biomarkers, the bioinformatics analysis to explore the prognosis biomarkers.

Official Title
-----------------
Prognostic Biomarkers of Pancreatic Cancer Based on Proteomics Techniques

Conditions
-----------------
Patients

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients of Chinese nationality, age and gender are not limited. Pathologically confirmed pancreatic cancer patients. Pathological specimens were archived tumor tissue samples after a diagnosis of pancreatic cancer. Clinical diagnostic information was complete three months before sampling. Exclusion Criteria: Patients with a second primary tumor.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Differentially expressed proteins in tumor and paracancer tissues | Two dimensional gel electrophoresis, mass spectrometry and other techniques were used to separate and compare pancreatic cancer tissues and normal adjacent tissues to search for differentially expressed proteins. | 180 Days |
Implementation of Directly Observed Hand Hygiene in Residential Care Home for the Elderly: a Cluster Randomized Trial

Study Overview
=================
Brief Summary
-----------------
To screen the prevalence of multidrug resistant organisms among the resident in the residential care home for the elderly, and assess the practicability of directly observed hand hygiene in this setting.

Official Title
-----------------
Implementation of Directly Observed Hand Hygiene in Residential Care Home for the Elderly: a Cluster Randomized Trial

Conditions
-----------------
Multidrug Resistant Organisms

Intervention / Treatment
-----------------
* Behavioral: Directly observed hand hygiene


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Residents living the residential care home for the elderly and able to give consent Exclusion Criteria: Those who cannot give consent
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Intervention<br>Directly observed hand hygiene | Behavioral: Directly observed hand hygiene<br>* Directly observed hand hygiene to the residents and staff<br>|
| No Intervention: Control<br>No directly observed hand hygiene | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Environmental contamination | Degree of environmental contamination | 6 weeks |
Genes and Phenotype (GAP) A National Resource for Genotype-Phenotype Studies of Immunological and Inflammatory Pathways

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to enrol generally healthy adults, who are asked to provide a blood sample, to study how the immune system works.

Detailed Description
-----------------
The primary purpose of this research is to develop a better understanding of how the immune system works. By studying immune function in many people, we will be able to determine the range of normal variation. The second purpose is to enroll people who are willing to serve as comparisons in future research studies into the Genotype and Phenotype Research Registry (GAP Registry). Volunteers are asked to provide information on age, ethnicity and medical history. Volunteers are asked to provide a blood sample of up to 100cc and allow us to contact you about additional studies.

Official Title
-----------------
Genes and Phenotype (GAP) A National Resource for Genotype-Phenotype Studies of Immunological and Inflammatory Pathways

Conditions
-----------------
Immune System Diseases

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Over age 18 Generally healthy Exclusion Criteria: History of autoimmune disease History of chronic immunodeficiency or chronic viral infections such as Epstein Barr virus, hepatitis or HIV Currently undergoing treatment for cancer Current treatment with immuno-suppressant drugs Pregnancy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Healthy Control Group<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of healthy participants enrolled | This is a registry to enroll healthy individuals who are interested in being contacted about research studies they can participate in as a healthy control | 5 years |
The Expression of Antigens in Bone Marrow Samples From Volunteering Donors.

Study Overview
=================
Brief Summary
-----------------
Antigen expression levels in bone marrow from volunteering donors will be analyzed. The results of this analysis will be used to establish a clinical test to identify cancer patients who could qualify to receive an investigational treatment being developed by GlaxoSmithKline.

Official Title
-----------------
Analysis of Expression of Antigens in Bone Marrow Samples From Volunteering Donors.

Conditions
-----------------
Cancer

Intervention / Treatment
-----------------
* Procedure: Bone marrow aspiration


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: The donor is aged >= 18 years Written informed consent has been obtained prior to the performance of any specific procedure. The donor has a medical indication for which a bone marrow aspiration is planned. The donor is eligible for a bone marrow aspiration.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group A<br>donors | Procedure: Bone marrow aspiration<br>* Collection of a 2 ml bone marrow sample from an aspirate carried out for medical purposes.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of copies of Wilms' Tumor 1 (WT1) antigen expression in bone marrow | Establishment of the range of WT1 transcript levels in a collection of bone marrow samples by real-time quantitative RT-PCR (Reverse Transcription Polymerase Chain Reaction). Due to the low numbers, they were expressed as [value x 10E-03]. Only the samples with gene expression >0 were presented. | At Day 0 | 
| Number of copies of PRAME (Preferentially expressed in melanoma)antigen expression in bone marrow | Establishment of the range of PRAME transcript levels in a collection of bone marrow samples by real-time quantitative RT-PCR (Reverse Transcription Polymerase Chain Reaction). Due to the low numbers, they were expressed as [value x 10E-03]. Only the samples with gene expression >0 were presented. | At Day 0 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
bone marrow, antigen expression, volunteers
Laboratory Study for the Acquisition of Spectral and Photoplethysmographic Data

Study Overview
=================
Brief Summary
-----------------
Laboratory study on healthy volunteers to acquire spectral video data from the tongue and fingers as well as photoplethysmographic data from the forehead, fingers, and earlobes to evaluate and optimize algorithms for imaging photoplethysmography (iPPG) and multispectral imaging (MSI)

Official Title
-----------------
Laborstudie Zur Aufnahme Spektraler Und Photoplethysmographischer Daten

Conditions
-----------------
Healthy Volunteers

Intervention / Treatment
-----------------
* Other: spectral imaging
* Other: photoplethysmography


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: healthy volunteers >= 18 years old Exclusion Criteria: pregnant and nursing women persons unable to consent persons with tattoos or diseases on the tongue, finger, ear, or forehead narcoleptics epileptics persons with arterial hypertension, peripheral arterial disease, anemia, Raynaud syndrome, autoimmune vasculitides, Takayasu arteritis, venous insuffiencies, microangiopathy, diabetic vasculopathy, scleroderma

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: spectral imaging|non-contact, non-invasive hyperspectral and multispectral imaging without a diagnostic test|
|Other: photoplethysmography|non-invasive pulse oximetry without a diagnostic test|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| RGB video data | true color video data (10 bit per channel [red, green, blue]) from tongues and fingers | 16 minutes | 
| hyperspectral data | false color parameter images, representing the oxygenation in %; the perfusion; the hemoglobin, water, and fat content of tissue in arbitrary units betwenn 0 and 100 from tongues and fingers (imaged areas have to correspond to RGB video data) | 16 minutes | 
| multispectral video data | true color video data (10 bit per channel [red, green, blue]) from tongues and fingers (imaged areas have to correspond to RGB video data) | 16 minutes | 
| plethysmographic wave | numerical value in arbitrary values representing the amount of transmitted/reflected light over time through fingers or earlobes or from the forehead | 5 minutes | 
| pulse | frequency in bpm (beats per minute) or Hz (Hertz) | 5 minutes | 
| pulsation index | ratio between pulsating and non-pulsating tissue components in % | 5 minutes | 
| SpO2 | oxygenation of arterial blood in %, measured with a pulse oximeter | 5 minutes |
Effect of Dill Seed on Uterus Contractions Pattern

Study Overview
=================
Brief Summary
-----------------
Dill is herbaceous and aromatic herb used in order to convenient and shorter labor in Iran. The objective of this study was to evaluate the effect of Dill seed on uterus contractions in active phase of labor.

Conditions
-----------------
Uterus Contractions Pattern

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 18-35 yrs, primiparous, having single fetus with cephalic presentation, gestational age 37-42 weeks, having no medical diseases, having no history of hospitalization due to psychological diseases, having no addiction to cigarette, having no complications during pregnancy such as hypertension, and BMI< 26.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Dill seed<br>used dill seed infusion (1 tablespoon whole dill seed seeped in a half or whole cup boiling water for 3-4 min) | |
| No used Dill seed<br>those who had not used any herbal drugs were placed at the control group | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Dill seed | used dill seed infusion (1 tablespoon whole dill seed seeped in a half or whole cup boiling water for 3-4 min) | up to 15 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Dill seed, Pattern of uterus contractions, Active phase of labor
Atrial Appendage Closure Prospective Observational Study

Study Overview
=================
Brief Summary
-----------------
The purpose of this research is to monitor how well patients do after surgery for treatment of left atrial appendage (LAA).

Detailed Description
-----------------
Patients will be followed in an observational study. We propose to do a single follow-up TEE at 3 to 6 months (this is standard of care) to confirm LAA (left atrial appendage) occlusion. The TEE is not mandatory (this is not a clinical trial), but will be strongly recommended to patients to confirm the efficacy of treatment. This will help confirm whether patients may safely remain off anticoagulation. The risks of TEE are a less than 1 in 1000 risk of death, and a 1% or less risk of a major complication, such as esophageal perforation.

Official Title
-----------------
LARIAT: Atrial Appendage Closure Prospective Observational Study

Conditions
-----------------
Atrial Fibrillation, Left Atrial Appendage Closure

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with Atrial fibrillation Are poor candidates to take warfarin Have elected to undergo a LARIAT procedure Exclusion Criteria: none

Ages Eligible for Study
-----------------
Minimum Age: 21 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical Progress | Patients who agree to participate in the registry will allow the Investigators to document their clinical progress and compare their progress to other participants in the study. Meanwhile, the patient will continue to receive routine care from their physician, just as they would if they did not participate in the study. Any information published as a result of this registry, will be kept anonymous. There is no known risk in participating in this study as it is only an observational study. | At regular visits ( 3 months and annually) | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
left atrial appendage closure
Consistencies in Responses to Sodium Bicarbonate?

Study Overview
=================
Brief Summary
-----------------
Intervention studies do not account for high within-individual variation potentially compromising the magnitude of an effect. Repeat administration of a treatment allows quantification of individual responses and determination of the consistency of responses. The investigators aim to determine the consistency of metabolic and exercise responses following repeated administration of sodium bicarbonate (SB). Design and Methods: 15 physically active males will complete six cycling capacity tests at 110% of maximum power output (CCT110%) following ingestion of either 0.3 g∙kg-1Body Mass of SB (4 trials) or placebo (PL, 2 trials). Blood pH, bicarbonate, base excess and lactate will be determined at baseline, pre-exercise, post-exercise and 5-min post-exercise. Total work done (TWD) will be recorded as the exercise outcome.

Official Title
-----------------
Consistencies in Responses to Sodium Bicarbonate Supplementation: a Randomised, Repeated Measures, Counterbalanced and Double-blind Study

Conditions
-----------------
Sports Nutritional Physiological Phenomena

Intervention / Treatment
-----------------
* Dietary Supplement: sodium bicarbonate
* Dietary Supplement: calcium carbonate


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: recreationally active males Exclusion Criteria: use of dietary supplements in the past 6 months the presence of any musculoskeletal disorder the use of anabolic steroids

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Placebo<br>0.3 g∙kg-1body mass of calcium carbonate | Dietary Supplement: calcium carbonate<br> <br> |
| Experimental: Sodium bicarbonate<br>0.3 g∙kg-1body mass of sodium bicarbonate | Dietary Supplement: sodium bicarbonate<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| blood pH |  | 5 min after a physical exercise test | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| blood bicarbonate |  | 5 min after a physical exercise test | 
| blood lactate |  | 5 min after a physical exercise test | 
| anaerobic exercise capacity | as assessed by cycling capacity tests at 110% of maximum power output | 4 hours after supplementation | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Physiological Phenomena
Resilience Curriculum for Novice Physicians-in-training

Study Overview
=================
Brief Summary
-----------------
To determine the feasibility of delivering a structured resilience curriculum to novice physicians-in-training, we propose a pilot study to evaluate recruitment rates, course attendance and compliance with follow-up surveys. If our study can demonstrate feasibility in course delivery, further engagement of postgraduate specialty programs will facilitate conduct of an appropriately powered randomised controlled trial.

Official Title
-----------------
Resilience Curriculum for Novice Physicians-in-training: a Randomized Controlled, Feasibility Trial.

Conditions
-----------------
Stress, Emotional

Intervention / Treatment
-----------------
* Behavioral: STRIVE curriculum


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All first and second year medical residents enrolled in the Schulich School of Medicine & Dentistry Anesthesia & Emergency Medicine postgraduate residency programs. Exclusion Criteria: None
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: STRIVE - Simulation Training for Resilience in Various Environments<br> | Behavioral: STRIVE curriculum<br>* STRIVE is adapted from the Road to Mental Readiness curriculum, developed by the Department of National Defence in Canada. It is comprised of a 4-hour formal education session where participants are provided knowledge, skills and resources specific to self-assessment for mental wellness and effective mindfulness strategies. High fidelity simulation sessions are then utilized to reinforce and apply mindfulness techniques learned in the formal session.<br>|
| Sham Comparator: Control<br> | Behavioral: STRIVE curriculum<br>* STRIVE is adapted from the Road to Mental Readiness curriculum, developed by the Department of National Defence in Canada. It is comprised of a 4-hour formal education session where participants are provided knowledge, skills and resources specific to self-assessment for mental wellness and effective mindfulness strategies. High fidelity simulation sessions are then utilized to reinforce and apply mindfulness techniques learned in the formal session.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Participant Recruitment Potential |  | 9 months | 
| STRIVE Course Completion | Number of participants randomized to the intervention that complete the STRIVE course | 9 months | 
| Follow-up Survey Compliance |  | 9 months |