linjc16/ctgov huggingface dataset:
Study the Role of Genetic Variation in the Determining Lipid Profile Response to Dietary Change

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine whether plasma lipoproteins and lipid responsiveness to a dietary modification is influenced by CETP gene polymorphism.

Official Title
-----------------
Study the Role of Polymorphism at the CETP Gene Locuse in the Determining Lipid Profile Response to Dietary Change

Conditions
-----------------
Metabolic Syndrome

Intervention / Treatment
-----------------
* Other: Dietary experiments


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy Volunteers Exclusion Criteria: History of any cardiovascular diseases type 1 diabetes type 2 diabetes use of lipid-lowering medications hypertension pregnancy Current intake of vitamins and supplements History of endocrin disorder

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br> | Other: Dietary experiments<br>* Dietary Supplement: high PUFA diet followed by high SFA diet<br>|
| Experimental: 2<br> | Other: Dietary experiments<br>* Dietary Supplement: high PUFA diet followed by high SFA diet<br>|
| Experimental: 3<br> | Other: Dietary experiments<br>* Dietary Supplement: high PUFA diet followed by high SFA diet<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Identification of Time-invariant EEG Signals for Brain-Computer Interface

Study Overview
=================
Brief Summary
-----------------
This study aims to identify various time-variant and time-invariant components of EEG signals using advanced signal processing techniques, such as machine learning. The investigators' ultimate goal is to develop universal or customised brain-computer interface that are stable across days or even years.

Official Title
-----------------
Identification of Time-invariant EEG Signals for Brain-Computer Interface

Conditions
-----------------
EEG Data Analysis, Healthy Subjects

Participation Criteria
=================
Eligibility Criteria
-----------------
Exclusion criteria: Severe vision disorders which prevent volunteers to recognize instructions on the screen Severe psychiatric disorders Severe sleep disorders which keep volunteers awake for two hours Volunteers with claustrophobia Patients who underwent stroke and brain surgery Patients with neuromuscular diseases

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time invariant components of EEG signals |  | One month | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
electroencephalogram (EEG),Human brain,Brain-Computer Interface
Optimizing Propofol in Obese Patients

Study Overview
=================
Brief Summary
-----------------
An accurate dosage of anesthetics during surgery is important. Usually this is achieved through close observation of the patient, but a new monitor (CSM-monitor) can measure the level of anesthesia more closely. In obese patients dosage of drugs is difficult due to the change in body composition. The CSM-monitor may provide a more accurate dosage of propofol (an anesthetic agent) during surgery, and as a consequence of that, also reduce the postoperative need for analgesics. Main objective: To optimise propofol dosing in obese patients undergoing hysterectomy. Main hypothesis: Monitoring the depth of anesthesia using the CSM-monitor reduces time to opening eyes in obese patients after hysterectomy in propofol anesthesia. Secondary hypotheses: CSM-monitoring reduce propofol dose in obese patients undergoing hysterectomy. Patients with a high CSM-level during hysterectomy have higher postoperative consumption of analgesics. Supplementary, an algorithm for the dose of propofol that most frequently results in a CSM-level between 40 and 60 is calculated.

Official Title
-----------------
Optimizing Propofol in Obese Patients

Conditions
-----------------
Hysterectomy

Intervention / Treatment
-----------------
* Drug: Propofol


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Elective abdominal non-laparoscopic hysterectomy Age > 18 years ASA physical status I-III Body Mass Index 30 or above Exclusion Criteria: Allergic towards propofol Daily consumption of benzodiazepines (more than at nighttime), opioids or amphetamine preoperatively. Disease with expected EEG-abnormality or impaired auditory function: Epilepsy, deafness, previous neurosurgery, previous or actual neurologic disease with neurologic deficit.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: A<br>General anesthesia titrated according to a cerebral state monitor | Drug: Propofol<br> <br> |
| Active Comparator: B<br>General anesthesia titrated according to usual clinical criteria | Drug: Propofol<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time to opening eyes in obese patients after hysterectomy in propofol anaesthesia. |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Propofol dose in obese patients undergoing hysterectomy. |  |  | 
| Postoperative consumption of analgesics. |  | 24 h after surgery | 
| The algorithm for the dose of propofol that most frequently results in a CSM-level between 40 and 60. |  |  |
Failure to Adjuvant Therapy After Pancreatic Resection for Pancreatic Cancer

Study Overview
=================
Brief Summary
-----------------
This study aims to evaluate the rate of patients submitted to pancreatic resection for pancreatic cancer, who fail to access to adjuvant therapy or do not complete adjuvant therapy. The purpose is to give an overview concerning the most frequent conditions and/or reasons associated with failure or omission of adjuvant therapy.

Detailed Description
-----------------
This prospective observational study will evaluate all patients submitted to pancreatic resection for pancreatic cancer. The rate of omission to adjuvant therapy and rate of failure of completion of adjuvant therapy will be evaluated as primary outcomes. As secondary outcomes, survival analyses will be performed to investigate whether these factors influence prognosis, that will be evaluated through a disease free survival analysis at 18-months. Epidemiological and perioperative data will be analyzed to identify conditions associated with the primary outcomes.

Official Title
-----------------
Failure to Adjuvant Therapy After Pancreatic Resection for Pancreatic Cancer: a Real Life Scenario

Conditions
-----------------
Pancreatic Malignant Neoplasm Primary

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Histologic diagnosis of pancreatic cancer Exclusion Criteria: Non exocrine pancreatic tumors Periampullary malignancies

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of patients who fail to receive adjuvant therapy and reasons for that | The amount of patients who will not receive adjuvant therapy after pancreatic resection for malignancy (when do indication exists) will be recorded | 6 months | 
| Rate of patients who fail to complete adjuvant therapy and reasons for that | The amount of patients who will not complete adjuvant therapy after pancreatic resection for malignancy will be recorded | 9 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Disease free survival of patients enrolled |  | 18 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Failure Adjuvant Therapy
Postoperative Pain After the Removal of Root Canal Filling Material

Study Overview
=================
Brief Summary
-----------------
The aim of this study was to evaluate the intensity and duration of postoperative pain after the removal of root canal filling material in retreatment procedures of upper incisor teeth with chronic apical periodontitis, using different techniques. The patients were assigned to three groups of 45 patients, according to the method used to remove old canal filling material. The presence of postoperative pain was assessed after 6, 12, 24, 48, and 72 hours, 7 days, and finally after 10 days. The hypothesis of this study: there would be no difference in postoperative pain intensity among the groups.

Official Title
-----------------
Postoperative Pain After the Removal of Root Canal Filling Material Using Different Techniques in Teeth With Failed Root Canal Therapy: A Randomized Clinical Trial

Conditions
-----------------
Postoperative Pain

Intervention / Treatment
-----------------
* Other: root canal therapy
* Other: root canal retreatment


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: asymptomatic incisor teeth with chronic apical periodontitis patients between 18-55 years of age Exclusion Criteria: patients with systemic disease
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: postoperative pain<br>postoperative pain | Other: root canal therapy<br>* effect of devices ( ProTaper and Reciprocal Files)<br>|
| Other: intensity<br>intensity | Other: root canal retreatment<br>* effect of devices ( ProTaper and Reciprocal Files)<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| postoperative pain after non-surgical endodontic retreatment using modified visual analog scale |  | 10 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Intensity
The TOGETHER Project - Kidney RNA-seq Validation

Study Overview
=================
Brief Summary
-----------------
The researchers are trying to develop a way to measure the risk of rejection through the validation of a blood test.

Official Title
-----------------
The TOGETHER Project - Transplant Organ Genomics to Help Prevent Rejection in Kidney Transplant Recipients-RNA-seq Signature Validation

Conditions
-----------------
Kidney Transplant Rejection

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adult (>/=18 years) renal transplant recipient. Patients who have given informed consent and are willing to comply with the protocol, including the use of their peripheral blood specimens and data for subsequent research. Exclusion Criteria: -Adult (<18 years) renal transplant recipient.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Kidney Transplant Receipients<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To validate the use of a RNA-seq based peripheral blood assay in renal transplant recipients. | The study will validate the ability of a peripheral blood assay to assess the risk of biopsy proven rejection. | 3 years |
Raynaud's Treatment Study (RTS)

Study Overview
=================
Brief Summary
-----------------
To determine the relative efficacy of usual medical care and a course of treatment by thermal biofeedback in reducing vasospastic attacks characteristic of Raynaud's syndrome. Also, to confirm the frequency and severity of attacks, examine the role of psychophysiological factors in precipitating attacks, and assess the influence of treatment on health quality of life.

Detailed Description
-----------------
BACKGROUND: Primary Raynaud's phenomenon is a peripheral vascular disorder resulting in vasospastic attacks provoked by cold and/or emotional stress. Attacks most often occur in the fingers, but may occur in other extremities as well. DESIGN NARRATIVE: Randomized. Patients were assigned to one of four treatment groups: slow release Nifedipine, a calcium channel blocker; pill placebo; temperature biofeedback; or electromyograph biofeedback from the frontalis muscle. The primary endpoint was reduction in number of vasospastic attacks. Other endpoints included: other measures of Raynaud's attacks including frequency, severity, duration, response to laboratory-based cold challenge, and quality of life.

Conditions
-----------------
Cardiovascular Diseases, Heart Diseases, Raynaud's Disease, Vascular Diseases

Intervention / Treatment
-----------------
* Drug: nifedipine
* Behavioral: biofeedback (psychology)
* Procedure: electromyography


Participation Criteria
=================
Eligibility Criteria
-----------------
Men and women with documented primary or secondary Raynaud's syndrome.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: nifedipine|nan|
|Behavioral: biofeedback (psychology)|nan|
|Procedure: electromyography|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
The Relationship of Abdominal Circumference and Trunk Length With the Level of Spinal Anesthesia in Obstetric Patients

Study Overview
=================
Brief Summary
-----------------
The body shape might have influence on the spinal level. In this research we plan to investigate the relationship of abdominal circumference, trunk length and the level of spinal anesthesia in obstetric patients during Cesarean section.

Detailed Description
-----------------
The level of spinal anesthesia in obstetric patients had been investigated in several studies. Increased cephalad spread of local anesthetics had been demonstrated with increased intra-abdominal pressure, changes in anteroposterior spinal curves and lumbar lordosis. Theoretically the body shape might have contribution to the above factors and might have influence on the spinal level. In this research we plan to investigate the relationship of abdominal circumference, trunk length and the level of spinal anesthesia in obstetric patients during Cesarean section. Only those C/S patients indicated and scheduled for spinal anesthesia will be observed. The spinal anesthesia will be performed as routine practice. This study will not change the clinical plan in any aspect. We will only passively record the abdominal circumference, trunk length and the level of spinal anesthesia and calculate the correlation between them.

Official Title
-----------------
The Relationship of Abdominal Circumference and Trunk Length With the Level of Spinal Anesthesia in Obstetric Patients

Conditions
-----------------
Obstetrics for C/S

Intervention / Treatment
-----------------
* Procedure: spinal anesthesia


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Obstetric patients for C/S Exclusion Criteria: With major systemic diseases

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| A<br> | Procedure: spinal anesthesia<br>* spinal anesthesia with bupivacaine<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
The Influences of Dry Eye Disease on Optical Quality

Study Overview
=================
Brief Summary
-----------------
DED could result in visual disturbance and damage optical quality. We aimed to evaluate the influences of dry eye disease (DED) on optical quality and their correlations.

Detailed Description
-----------------
This study is aimed at evaluating changes of optical quality in dry eye patients with superficial punctate keratopathy after being treated by artificial lubricant and anti-inflammatory eye drops.

Official Title
-----------------
The Influences of Dry Eye Disease on Optical Quality

Conditions
-----------------
Dry Eye, Vision; Disturbance, Hysterical

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients were diagnosed as dry eye according to the criteria provided by the Dry Eye Workshop (DEWS) positive corneal fluorescein staining (CFS) best-corrected distance visual acuity better than 20/20. Exclusion Criteria: History of ocular surgeries, contact lens wear, meibomian gland dysfunction, and any type of corneal scarring such as dystrophies or infections.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Normal<br>healthy subjects | |
| Dry eye group<br>patients with dry eye | |
| Dry eye after treatment<br>patients with dry eye after treatment | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The severity of DED influenced the optical quality of dry eye patients | The optical quality of dry eye patients | 2017.7-2019.7 | 
| High order abberations | cornela high order abberations of patients | 2017.7-2019.7 |
Cell Marker Predictors in Barrett's Esophagus

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to analyze biopsied tissue samples for changes in cells and genes involved in Barrett's Esophagus.

Detailed Description
-----------------
Patients with a history of Barrett's esophagus who are scheduled for a routine endoscopy will have an additional biopsy taken for genetic testing.

Official Title
-----------------
Cell Marker Predictors in Barrett's Esophagus

Conditions
-----------------
Barrett's Esophagus Without Dysplasia

Intervention / Treatment
-----------------
* Other: Tissue sample for genetic testing


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: History of Barrett's esophagus; scheduled for routine upper endoscopy Exclusion Criteria: Under 18 years of age Unable to consent on own behalf

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Tissue Sample for genetic testing<br>Biopsy sample | Other: Tissue sample for genetic testing<br>* Tissue sample to be obtained during routine endoscopy<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cell Markers | Identify genes involved in Barrett's Esophagus | through study completion, an average of 1 year |