Electrolytes in Chronic Kidney Disease Patients With Acute Coronary Syndrome

Study Overview
=================
Brief Summary
-----------------
Study of serum calcium and phosphorus level in chronic kidney disease patients and its relation to occurrence of acute coronary syndrome in them.

Detailed Description
-----------------
Prospective study to : find the relation between electrolytes disturbance and renal diseases the effect of electrolyte abnormalities on atherosclerosis prevalence of acute coronary syndrome in patients with chronic kidney disease

Official Title
-----------------
Study of Serum Calcium and Phosphorus Level in Chronic Kidney Disease Patients With Acute Coronary Syndrome

Conditions
-----------------
Acute Coronary Syndrome

Intervention / Treatment
-----------------
* Diagnostic Test: Serum Calcium


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 1-The CKD patients with or without dialysis who admitted to coronary care unit with chest pain consistent with ACS with any of following features : a- Electrocardiogram (ECG) changes: ST elevation. ST depression. T wave inversion. recent left bundle branch block. b- Troponin T elevation. 2-The CKD patient with or without dialysis with no previous history of ACS. Exclusion Criteria: Patients who were diagnosed with primary hyperparathyroidism. Acute Kidney injury (AKI) which is defined as any of the following:(KDIGO2012) Increase in S.Cr by ≥ 0.3 mg/dl (≥ 26.5 μmol/l) within 48hours; or Increase in S.Cr to ≥ 1.5 times baseline, which is known or presumed to have occurred within the prior 7 days;or Urine volume <0.5 ml/kg/h for 6 hours

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Chronic Kidney Disease (CKD) patients with acute coronary syndrome<br>The CKD patients with or without dialysis who admitted to coronary care unit with chest pain consistent with ACS with any of following features : Electrocardiogram (ECG) changes: ST elevation. ST depression. T wave inversion. recent left bundle branch block. Troponin elevation. | Diagnostic Test: Serum Calcium<br>* Serum calcium level. Serum phosphorus level. will be measured to all study population<br>* Other names: serum Phosphorus;|
| Chronic Kidney Disease (CKD) patients without acute coronary syndrome<br>The CKD patient with or without dialysis with no previous history of ACS. | Diagnostic Test: Serum Calcium<br>* Serum calcium level. Serum phosphorus level. will be measured to all study population<br>* Other names: serum Phosphorus;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Chronic kidney disease hospitalization | The CKD patient with and without acute coronary syndrome and estimated hazard ratios (HR) by use of multivariable Cox regression models. | from the day of admission to the day of discharge through study completion, an average of 28 weeks, in sohag university hospital |