Myocardial Involvement of Severe Acute Respiratory Syndrome-Cov-2 (Covid19) Infected Patients

Study Overview
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Brief Summary
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The effects of severe acute respiratory syndrome SARS-Cov-2 (Covid-19) on the myocardium and their role in the clinical course of infected patients are still unknown. Epidemiological studies report biological myocardial involvement in 10 to 25% of cases. The objective of this study is to cardiac phenotype using comprehensive cardiac imaging tools of patients infected with Covid 19 in order to explore the functional impact of the infection on the myocardium.

Detailed Description
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A large population of Covid 19 infected patients of different ages and severity levels will be explored by transthoracic echocardiography with measurement of myocardial functional parameters such as ejection fraction, longitudinal strain and relaxation parameters and will be compared to an uninfected population paired for age and sex. Patients with biological myocardial involvement will be followed to determine the evolution of their myocardial functional parameters during the course of the infection.

Official Title
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Imaging Cardiac Phenotype of SARS-Cov-2 (Covid19) Infected Patients

Conditions
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Cardiomyopathies

Intervention / Treatment
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* Diagnostic Test: Global Longitudinal Strain


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Major patients hospitalized for respiratory criteria for SARS-Cov-2 infection confirmed by RT-PCR Exclusion Criteria: Underage patients. Patients refusing to participate in research. Patients with a history of heart disease.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| COVID + patients<br>Major patients hospitalized for respiratory criteria for SARS-Cov-2 infection confirmed by RT-PCR | Diagnostic Test: Global Longitudinal Strain<br>* Electrocardiogram with measure of the Global Longitudinal Strain to evaluate myocardiac dysfunction<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Left ventricular function | Left ventricular function evaluated by global longitudinal strain | Day 0 | 
| Left ventricular function | Left ventricular function evaluated by global longitudinal strain | Day 3 | 
| Left ventricular function | Left ventricular function evaluated by global longitudinal strain | Day 7 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| inflammatory biological parameters | Cytokine rate | Day 0 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Left ventricular systolic function, left ventricular diastolic function, global longitudinal strain, SARS-Cov-2, Covid-19