The Use of Antipsychotics in the Program of All-inclusive Care for the Elderly (PACE)

Study Overview
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Brief Summary
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The aim of this study is to retrospectively evaluate and describe the use of antipsychotics among participants enrolled in the Program of All-inclusive Care for the Elderly (PACE), a community-based practice setting.

Detailed Description
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Much national attention has been given to assessing and reducing the use of antipsychotics among nursing home residents, yet comparatively little attention has focused on antipsychotic use among older adults receiving care in community-based settings. The primary objective of this study is to determine the prevalence of antipsychotic use among a nationally representative sample of nursing home-eligible older adults in a community-based practice setting known as Program of All-inclusive Care for the Elderly (PACE). The secondary objectives are focused on characterizing antipsychotic use within PACE and for these participants. Specifically, the investigator's secondary objectives are to describe patterns of other drugs concomitantly used with antipsychotics (e.g., benzodiazepines, opioids) and to identify clinically relevant drug-drug interactions involving antipsychotics.

Official Title
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Antipsychotic Use Within the Program of All-inclusive Care for the Elderly (PACE)

Conditions
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Behavioral and Psychiatric Symptoms of Dementia

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Participant enrolled in PACE contractually receiving pharmacy services from Tabula Rasa Healthcare CareKinesis Pharmacy (Tabula Rasa HealthCare) during the project time period (January 2017 through December 2017). Exclusion Criteria: Participant with a diagnosis of bipolar disorder and/or schizophrenia, according to pharmacy records.

Ages Eligible for Study
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Minimum Age: 55 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Study group<br>Participants enrolled in PACE who received an antipsychotic medication. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prevalence of Antipsychotic Use | Quantitative description of antipsychotic use as assessed by pharmacy records | 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Concomitant Drug Use with Antipsychotics | Qualitative and quantitative description of patterns of other drugs concomitantly used with antipsychotics as assessed by pharmacy records | 12 months | 
| Drug-Drug Interactions | Qualitative and quantitative description of drug-drug interactions involving antipsychotics as assessed by proprietary clinical decision support system (CDSS) | 12 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Antipsychotic, Dementia