Comparison of Three Calcium Supplements

Study Overview
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Brief Summary
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The study was conducted to investigate the metabolic effects of three different calcium compounds in healthy adults.

Official Title
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Comparison of Three Calcium Supplements With Regard to Their Metabolic Effects in Healthy Adults

Conditions
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Healthy

Intervention / Treatment
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* Dietary Supplement: calcium phosphate
* Dietary Supplement: Tricalcium Phosphate
* Dietary Supplement: Calcium carbonate
* Dietary Supplement: Placebo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age 18 - 40 years Exclusion Criteria: diseases of the gastrointestinal tract pregnancy the intake of any medication (e. g. for thyroid gland) intake of dietary supplements

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: calcium phosphate<br>Pentacalcium hydroxy-triphosphate (Ca5(PO4)3OH) was incorporated in wholemeal and crispy wafer bread in order to achieve a additional calcium intake of 1000 mg/d. | Dietary Supplement: calcium phosphate<br> <br> |
| Experimental: Tricalcium Phosphate<br>β-tricalcium phosphate (Ca3(PO4)2) as incorporated in wholemeal and crispy wafer bread in order to achieve a additional calcium intake of 1000 mg/d. | Dietary Supplement: Tricalcium Phosphate<br> <br> |
| Experimental: Calcium carbonate<br>Calcium carbonate (CaCO3) was incorporated in wholemeal and crispy wafer bread in order to achieve a additional calcium intake of 1000 mg/d. | Dietary Supplement: Calcium carbonate<br> <br> |
| Active Comparator: Placebo<br>Wholemeal and crispy wafer bread without additional calcium additive. | Dietary Supplement: Placebo<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Serum mineral concentration | Calcium and Phosphate (and others) concentration in serum. | after 4 weeks of each intervention | 
| Stool mineral concentration | Calcium and Phosphate concentration (and others) in stool from a three day stool collection | after 4 weeks of each intervention | 
| Urine mineral concentration | Calcium and Phosphate concentration (and others) in urine from a three day urine collection | after 4 weeks of each intervention | 
| Lipids in blood | Lipids and lipoprotein concentration in serum. | after 4 weeks of each intervention | 
| Sterols | Neutrals sterols and bile acids in stool from a three day stool collection | after 4 weeks of each intervention | 
| Dietary intake | Evaluation of the dietary intake using a three day weighed dietary record. | after 4 weeks of each intervention | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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calcium carbonate, calcium phosphate, metabolic effects, human study, calcium and phosphorus metabolism