Histomolecular Profiles of Gliomas in Children and Adolescent/Young Adults

Study Overview
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Brief Summary
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In the last decades, many advances have been made in the field of genetic abnormalities of glial and glioneuronal brain tumors. In the 2016 World Health organization (WHO) Classification of Tumors of the Central Nervous System, the concept of integrated diagnosis emerged: histological and genetic/molecular features now define many entities. Since 2016, six updates have been published by the c-IMPACT-NOW (the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy- Not Official WHO) to develop and clarify the integrated diagnosis. In the future WHO 2021 Classification of Tumors of the Central Nervous System, integrated diagnoses will take up even more importance. Even if they can have similar histological features, gliomas of children are very different from the adult gliomas in the molecular mechanism of oncogenesis. The histomolecular features of adolescents/young adults (AYAs) can have similarities with pediatric-type or adult-type gliomas, but few studies have focused specifically on the histomolecular profiles of gliomas in AYAs. The investigators would like to study the cohort of patients treated for a glial and glioneuronal tumor diagnosed under the age of 25 in the Amiens University Hospital between 2008 and 2020. The investigators would like to compare the histomolecular profiles of gliomas in children (0-14 years) and AYAs (15-25 years).

Official Title
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Comparative Study of the Histomolecular, Radiological and Prognostic Profiles Between Brain Gliomas of Children (0-14 Years) and Adolescents/Young Adults (15-25 Years) Treated in the Amiens University Hospital Between 2008 and 2020

Conditions
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Histological, Molecular Sequence Variation, Glioma

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Male or female patient Patient treated in the Amiens University Hospital Patient treated for a glial or glioneuronal brain tumor according to the 2016 WHO Classification of Tumors of the Central Nervous System (diffuse oligodendroglia or astrocytoma tumour, another astrocytic tumor, another glioma or a mixed neuronal or glioneuronal tumour). Diagnosis histologically confirmed or formally established by radiologist. Diagnosis established between January 1, 2008 and December 31, 2020. No patient opposition (from adult patient, or from the holder of parental authority of the minor patient). Exclusion Criteria: Uncertain diagnosis Patient opposition (from adult patient, or from the holder of parental authority of the minor patient).

Ages Eligible for Study
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Maximum Age: 25 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| children (0-14 years)<br> | |
| AYAs (15-25 years)<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Histogical glioma differences between child group(0-14 years) and AYA group (15-25 years) |  | one year | 
| Molecular glioma differences between child group(0-14 years) and AYA group (15-25 years) |  | one year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Variation of glioma MRI profile between child group(0-14 years) and AYA group (15-25 years) | MRI profiles are EPI T2* MRI profiles | one year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Histological, Molecular, Glioma, adolescents/young adults, Children