Hypoalbuminemia in Mild Acute Stroke and Cognitive Impariment Post-stroke

Study Overview
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Brief Summary
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This registration enrolled patients with acute ischemic stroke within 72 hours after stroke ictus. Patients was identified as first-ever stroke based on past medical histrory. Admission CT was conducted to exclude hemorrhagic stroke, but not those bleeding transformation after ischemia injury. Baseline characteristics, including demographics, vascular risk factors, lab tests and neuroimagings were collected. Patients were followed up for cognitive assessments.

Detailed Description
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This is a perspective stroke registry cohort study. Stroke patients were included if ：(1) acute first-ever ischemic stroke and admitted within 72 hours after onset; (2) clinical stroke diagnosis was confirmed with positive diffusion-weighted magnetic resonance imaging (DW-MRI), those with isolated posterior circulations infarcts were exclude ; (3) presented with mild stroke severity ( admission NIHSS score ≤5); (4) age between 40 and 80 years. Clinical data including demographic characteristics, risk factors, and baseline NIHSS score were assessed and collected using a standardized table by experienced neurologists. Lab tests were performed with fasting venous blood samples within 18 hours of admission. Patients were followed up for 6 months. The cognitive functions were assessed using the Chinese version of Montreal Cognitive Assessment (MoCA). Contributing factors to post-stroke cognitive impariment (PSCI) were determined by comparing clinical data between PSCI and non-PSCI groups. All potential confounders were introduced into the multivariate regression models.

Official Title
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Relationship Between Baseline Serum Albumin Level and Cognitive Impariment in Mild Acute Ischemic Stroke

Conditions
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Cognitive Impairment, Stroke, Albumin; Double

Intervention / Treatment
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* Other: strengthened nuitritional treatment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: acute first-ever ischemic stroke and admitted within 72 hours after onset; clinical stroke diagnosis was confirmed with positive diffusion-weighted magnetic resonance imaging (DW-MRI), those with isolated posterior circulations infarcts were exclude ; presented with mild stroke severity ( admission NIHSS score ≤5); age between 40 and 80 years. Exclusion Criteria: Patients with index cognitive impairment or under current anti-dementia or psychiatric medication; patients with large infarcts (≥1/3 middle cerebral artery territory); patients with severe language or physical disability that impede neuropsychological testing; patients with recurrent transient ischemic attack (TIA)/stroke during follow-up; coexisting serious conditions known to impair cognitive function

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| hypoalbuminemia<br>hypoalbuminemia was classified as serum albumin level (SAL) <35g/L | Other: strengthened nuitritional treatment<br>* improving nutritional status by nasal feeding for dysphagia or iv. albumin when serum albumin level lower than 35g/L<br>|
| normal albumin level<br>patients with serum albumin level (SAL) of 35g/L or higher | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| PSCI | Patients with a MoCA score of <24 were categorized as having PSCI | 6 months post-stroke |