Measurement of Anterior Chamber Cell Grading Using Ocular Coherence Tomography

Study Overview
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Brief Summary
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Optical Coherence Tomography (OCT) is routinely used in ophthalmic clinical practice. It uses infrared light to image patient's eyes. Some patients, such as those with an inflammatory disease called uveitis or those who have just undergone cataract surgery, have intraocular inflammation. This intraocular inflammation commonly manifests as cells that can be seen on routine microscopic clinical examination. However, the only currently available method to quantify this intraocular inflammation is by manually counting on the microscopic clinical examination. The investigators plan to use the OCT machine to image patient's eyes. The investigators will then use the images obtained from the OCT to objectively quantify the degree of intraocular inflammation.

Official Title
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Objective, Prospective Measurement of Anterior Chamber Cell Grading Using Anterior Chamber Ocular Coherence Tomography

Conditions
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Uveitis

Intervention / Treatment
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* Device: Optical Coherence Tomography (OCT)
* Other: Eye Exam


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age over 18 years old Intervention Arm: Active anterior chamber inflammation in at least one eye as diagnosed by clinical exam One of the following: 1) diagnosis of uveitis OR 2) undergone cataract extraction surgery within the previous 30 days Control Arm: No active intraocular inflammation based on clinical exam Exclusion Criteria: Corneal opacities in the affected eye Anyone judged unable to understand or consent to study participation

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Uveitis and Cataract Imaging Group<br>Subjects will undergo up to three optical coherence tomography scans. | Device: Optical Coherence Tomography (OCT)<br>* The OCT scan is a brief, non-contact scan of the back of the eye using infrared light. Subjects will see a light and be asked to look forwards while the scan is completed.<br>|
| Experimental: Control<br>Control subjects will undergo a brief, non-contact eye exam and then undergo up to three optical coherence tomography scans. | Device: Optical Coherence Tomography (OCT)<br>* The OCT scan is a brief, non-contact scan of the back of the eye using infrared light. Subjects will see a light and be asked to look forwards while the scan is completed.<br>Other: Eye Exam<br>* This is a brief, non-contact ocular exam.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of Participants With Identified Inflammatory Cells on OCT Scan | This measure pertains to the identification of cells in OCT scan of the participants. The inflammatory cells to be identified refer to white blood cells. The anterior segment OCT scan was used to attempt to identify these cells in the anterior chamber of the eyes of the participants. | Through study completion, up to 1 year. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Cell Density Identified by OCT Scans Over Time | Identification of changes in cell density in OCT scans over time | Baseline and up to 8 weeks. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Uveitis, Optical Coherence Tomography