linjc16/ctgov huggingface dataset:
Validation of Predictive Scale of Chronic Postsurgical Pain

Study Overview
=================
Brief Summary
-----------------
To asses the precision of a score to predict chronic post surgical pain in patients undergoing inguinal hernia repair, abdominal hysterectomy, vaginal hysterectomy and thoracotomy. Prospective multicenter cohort study in 21 hospital in spain.

Official Title
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Prospective External Validation of a Predictive Scale of Chronic Postsurgical Pain

Conditions
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Chronic Postoperative Pain

Intervention / Treatment
-----------------
* Procedure: Inguinal hernia repair
* Procedure: Abdominal hysterectomy
* Procedure: Vaginal hysterectomy
* Procedure: Thoracotomy


Participation Criteria
=================
Eligibility Criteria
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Inclusion Criteria: Patients with given inform consent, aged mor than 18 years, who undergo scheduled surgery of one of the following types: inguinal hernia (men), abdominal hysterectomy, vaginal hysterectomy and thoracotomy (men) Exclusion Criteria: Patients aged less than 18 years, Patients requiring reoperation because of surgical complications.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Chronic post-surgical pain patients<br>Patients scheduled for differents types of surgery (inguinal, hernia repair, abdominal hysterectomy, vaginal hysterectomy, and thoracotomy). | Procedure: Inguinal hernia repair<br> <br> Procedure: Abdominal hysterectomy<br> <br> Procedure: Vaginal hysterectomy<br> <br> Procedure: Thoracotomy<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| GENDOLCAT scale punctuations (composed by 6 items: type of surgery, age, pain in area of surgery, pain in other localisations, physical component of SF12 and mental component of SF12). | GENDOLCAT scale punctuations (composed by 6 items: type of surgery, age, pain in area of surgery, pain in other localisations, physical component of SF12 and mental component of SF12) to identify patients that could develop chronic post surgical pain after inguinal hernia repair, abdominal hysterectomy, vaginal hysterectomy and thoracotomy. | After evaluation of chronic postsurgical pain 4th month after the end of surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Verbal rating scale | Prevalence of chronic post surgical pain after inguinal hernia repair, abdominal hysterectomy, vaginal hysterectomy and thoracotomy will be assessed by verbal rating scale. | After evaluation of chronic postsurgical pain 4th month after the end of surgery |
Assessment of Esthetics and Patient-reported Outcomes of Single Implant Crowns

Study Overview
=================
Brief Summary
-----------------
The aim of this retrospective study is to perform an assessment of esthetic outcomes of single implants and obtain patient reported outcome measures through the use of a satisfaction questionnaire and the OHIP-14 (Oral Health Impact Profile) questionnaire. Dentists will be performing clinical examination including teeth charting and periodontal charting as well as pink/white esthetic score assessment and these outcomes will be compared to the level of patient satisfaction and patient reported outcomes. The results of this research will add evidence-based data on treatment recommendations for teeth replacement with implants from a patient-centered perspective.

Official Title
-----------------
Retrospective Assessment of Esthetics and Patient-reported Outcomes of Single Implant Crowns

Conditions
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Pink and White Esthetic Scores, Patient Outcome Measures

Intervention / Treatment
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* Other: Regular dental examination


Participation Criteria
=================
Eligibility Criteria
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Inclusion Criteria: Patients 18 years or older Good oral hygiene Single implant crown in the esthetic zone (maxillary 2nd premolar to 2nd premolar) Implant crown surrounded by natural teeth Implant crown opposed by natural dentition or fixed prostheses Implant crown has been installed for at least one year Exclusion Criteria: Presence of active infection around the implant Presence of active periodontal disease in the esthetic area. Opposing removable prosthesis

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Single implant crowns in the anterior maxilla<br>No drugs to be administered. Patients who have had a single implant crown placed since more than one year in the anterior maxilla (second premolar to second premolar) will be invited for a review session for dental examination and to fill the Oral Health Impact Profile (OHIP) questionnaire. | Other: Regular dental examination<br>* Regular dental examination, and the patient will be asked to fill a questionnaire<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| PES/WES scores of single implant crowns in the anterior maxilla | Assessment of pink esthetic score/white esthetic score (PES/WES) scores for implant supported prostheses | the single implant crown should be 1 year to 15 years in function | 
| OHIP questionnaire patient reported outcome | Assessment of patient reported satisfaction with esthetics of implant supported single crowns | the single implant crown should be 1 year to 15 years in function |
Probiotics Against Low Grade Inflammation and Increased Intestinal Permeability in the Elderly

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate the ability of a blend of berries and probiotics in reducing low-grade inflammation and intestinal permeability in the elderly. The intervention period is one month. Blood and fecal samples will be collected for analysis at baseline and at the end of the intervention with the aim to analyse possible changes in different parameters at the two timepoints. The participants will also be asked to keep a study diary throughout the study period for the documentation of their intestinal health and as a means for checking compliance.

Official Title
-----------------
Probiotics Against Low Grade Inflammation and Increased Intestinal Permeability in the Elderly.

Conditions
-----------------
Low-grade Inflammation, Increased Intestinal Permeability

Intervention / Treatment
-----------------
* Dietary Supplement: Placebo
* Dietary Supplement: Active, only probiotics
* Dietary Supplement: Active, blend of berries and probiotics


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age >75 years CRP 2-10 mg/L Ability to fill in a study diary by him/herself Exclusion Criteria: Intake of antibiotic treatment in the last 4 weeks before inclusion into the study. Currently on corticosteroid treatment Presence of chronic inflammatory disease

Ages Eligible for Study
-----------------
Minimum Age: 75 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Placebo<br>Powder consisting of maltodextrine, treated to resemble the Active product in appearance and taste. | Dietary Supplement: Placebo<br>* Powder<br>|
| Active Comparator: Active, only probiotics<br>Powder consisting of freezedried bacteria at 10 billions cfu/daily dose and maltodextrine, treated to resemble the Active product in appearance and taste. | Dietary Supplement: Active, only probiotics<br>* Powder<br>|
| Active Comparator: Active, blend of berries and probiotics<br>Powder consisting of freezedried berries , probiotics at 10 billions cfu/daily dose and maltodextrine. | Dietary Supplement: Active, blend of berries and probiotics<br>* Powder<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Reduced intestinal permebility measured as decline in the levels of zonulin in blood samples |  | All blood markers analysed in the study will be measured at start, before the onset of intervention and 4 weeks later at the end of intervention. |
Fundus Autofluorescence After Vitrectomy for Epiretinal Membrane

Study Overview
=================
Brief Summary
-----------------
Fundus autofluorescence (FAF) at the macula originates from hyperfluorescence from retinal pigment epithelium (RPE) and blockage of hyperfluorescence by macular pigment. Investigators evaluate whether presence of FAF may correlate to the postoperative visual outcome for epiretinal membrane.

Detailed Description
-----------------
92 eyes with epiretinal membrane were performed vitreous surgery, epiretinal membrane removal and internal limiting membrane (ILM) peeling. Presence of hyperfluorescence in FAF at the macular area and best-corrected visual acuity (BCVA) was evaluated preoperatively and at postoperative 1, 3, and 6 months with ultra-wide angle imaging.

Official Title
-----------------
Correlation of Postoperative Vision and Fundus Autofluorescence After Vitrectomy for Epiretinal Membrane

Conditions
-----------------
Epiretinal Membrane

Intervention / Treatment
-----------------
* Procedure: Vitrectomy with internal limiting membrane removal


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: The inclusion criteria were patients who underwent vitrectomy and internal limiting membrane removal for epiretinal membrane and had followed for more than 6 months. Exclusion Criteria: The patients with follow-up less than 6 months.

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 90 Years


Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Vitrectomy with internal limiting membrane removal|Vitrectomy with removal of epiretinal membrane and internal limiting membrane|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Visual acuity before and after surgery | Vision | Changes from baseline to 1, 3, 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Presence of fluids autofluorescence at the macular area | Fundus autofluorescence | Changes from baseline up to 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Epiretinal membrane
Obesity-asthma Endophenotype and Diaphragm Mobility in Adolescence

Study Overview
=================
Brief Summary
-----------------
Obesity and asthma share changes that may begin in the fetal development phase. The endophenotype obesity-asthma presents as main characteristic a pattern of inflammatory response different from the habitual Th2 profile of cytokines. In these obese patients, possible changes in the diaphragm muscle can directly influence the dynamics of pulmonary ventilation significantly. Due to the importance of the diaphragm in pulmonary ventilation, this study will be performed to verify possible alteration in the excursion and diaphragmatic thickness of adolescents with endophenotype obesity-asthma. In parallel, the possible underlying etiopathogenic substrate of this endophenotype will be explored through the dosing of muscle enzymes and inflammatory cytokines and obesity hormones.

Official Title
-----------------
Obesity-asthma Endophenotype: Assessment of Diaphragm Mobility and Muscle Inflammation Markers in the Adolescence

Conditions
-----------------
Obesity, Asthma

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adolescents of both sexes, aged 12-21 years; For the obesity groups, BMI for gender and age equal to or greater than the 97th percentile; Clinical diagnosis of persistent, moderate and severe asthma by a specialist physician and its severity classified according to the GINA (Global Initiative Against Asthma) criteria. Exclusion Criteria: Adolescents with a diagnosis of cardiovascular, rheumatic, osteoarticular, neuromuscular or any other disease that limits the safe performance of the tests proposed by the protocol will be excluded; And those who do not agree to participate in the study.

Ages Eligible for Study
-----------------
Minimum Age: 12 Years
Maximum Age: 21 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Obesity Group<br> | |
| Asthma Group<br> | |
| Obesity-Asthma Group<br> | |
| Control<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diaphragm mobility | Change in mm of diaphragm mobility. | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diaphragm thickness | Change in cm of diaphragm thickness. | 1 day | 
| Th1 Cytokine Levels | Change in pg/mL of Th1 Cytokines | 1 day | 
| Th2 Cytokine Levels | Change in pg/mL of Th2 Cytokines | 1 day | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
obesity, asthma, diaphragm excursion, pulmonary function test
The Effect of Timing of Transcranial Direct Current Stimulation (tDCS) for Enhancing Learning During Cognitive Training

Study Overview
=================
Brief Summary
-----------------
This project will investigate a novel strategy for enhancing cognitive training (CT). Specifically, the investigators aim to combine a non-invasive form of brain stimulation (tDCS) with CT. This study will examine the optimal time interval - whether tDCS should be administered either before or during CT.

Official Title
-----------------
The Effect of Timing of Transcranial Direct Current Stimulation (tDCS) for Enhancing Learning During Cognitive Training

Conditions
-----------------
Effects on Learning

Intervention / Treatment
-----------------
* Device: Transcranial direct current stimulation (tDCS)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Participants will be healthy right-handed subjects aged 18 to 40 years. Exclusion Criteria: Concurrent medication likely to affect mental performance, Current history of drug or alcohol abuse or dependence, Any psychiatric or neurological disorder, Recent head injury, or history of seizure or stroke.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Timing of tDCS<br> | Device: Transcranial direct current stimulation (tDCS)<br>* Eldith Direct Current Stimulator (NeuroConn GmbH, Germany)<br>|
| Experimental: Alternative timing of tDCS<br> | Device: Transcranial direct current stimulation (tDCS)<br>* Eldith Direct Current Stimulator (NeuroConn GmbH, Germany)<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in performance across each condition. | D prime, number of correct responses, and number of errors. | Over 2 days, with each condition conducted 1 month apart. |
Effect of Probiotics in Childhood Abdominal Pain

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to assess the effect of probiotics in childhood recurrent abdominal pain. Patients will be randomly assigned to receive L. reuteri or placebo for 4 weeks with a follow up phase of additional 4 weeks.

Detailed Description
-----------------
Prospective randomized double-blind placebo-controlled trial.

Official Title
-----------------
The Effect of Probiotics in Childhood Abdominal Pain

Conditions
-----------------
Abdominal Pain

Intervention / Treatment
-----------------
* Dietary Supplement: Probiotics
* Dietary Supplement: Placebo


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy children Exclusion Criteria: Any chronic or organic illness

Ages Eligible for Study
-----------------
Minimum Age: 6 Years
Maximum Age: 15 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Probiotics supplementation<br>Supplementation by probiotics for 4 weeks | Dietary Supplement: Probiotics<br>* Daily oral supplementation for four weeks<br>* Other names: probiotic agent, L. reuteri;|
| Placebo Comparator: Placebo<br>Supplementation of placebo for 4 weeks | Dietary Supplement: Placebo<br>* Placebo administration<br>* Other names: placebo tablets;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Frequency and intensity of abdominal pain | Number of pain episodes and pain intensity based on a visual scale | Eight weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| School absenteeism | Number of patients with school absenteeism | Eight weeks | 
| Other gastrointestinal symptoms | Any gastrointestinal symptom such as nausea, vomiting, diarrhea, bloating | Eight weeks | 
| Adverse effects related to treatment | Any adverse effects related to the probiotic supplementation | Eight weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
childhood, abdominal pain, probiotics
The Impact of the Head Position on the Occlusion of Implant-supported Fixed Restorations

Study Overview
=================
Brief Summary
-----------------
The development of a implantology leads to an increasing use of implants in the treatment of care for the loss of one or more teeth. The question is whether the existing guidelines, originally formulated for the occlusion of natural dentition and conventional prosthetic treatment can be applied to the implant prosthodonticsDue to initial differences in the vertical mobility of teeth and dental implants, present in the same dental arch, although the model of occlusion is ideal, undesirable premature occlusal contacts on the fixed dental restorations on implants may be present. Objective: To evaluate the effect of different head positions on dental occlusion of the natural teeth and fixed dental restorations on implants. Methods: Volunteers with complete dentition would be included in this study as the Control Group. The Study Group would include subjects with fixed dental restorations on implants in the transcanine region. A T Scan III System will be used for occlusal analysis.

Official Title
-----------------
The Impact of the Head Position on the Occlusion of Implant-supported Fixed Restorations vs. Natural Dentition - a Cross-sectional Analysis

Conditions
-----------------
Dental Occlusion

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: For the Test Group patients with implant-supported fixed restorations in at least one quadrant of the posterior region (pre-molar and molar) of both jaws at least for 1 year patients with Angle Class I in MIP patients who did not have orthodontic treatment For the Control group, the inclusion criteria were: - patients with completely dentate arches (not considering third molars) with a maximum of 4 tooth-supported restorations per dental arch). Exclusion Criteria: patients with bruxism, detrimental habits, and mandibular parafunctional activities patients with signs of temporomandibular dysfunction, trismus, or illness of the cervical spine patients with a history indicating problems with alcohol or drugs or receiving any psychiatric treatment.

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 55 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in occlusal contacts distribution in 3 different head positions | Computerized occlusal analysis | Baseline-1 year | 
| Changes in relative forces strength in 3 different head positions | Computerized occlusal analysis | Baseline-1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
dental occlusion, head posture, fixed dental restorations, dental implants, implant occlusion, computerized occlusal analysis