A Prospective Study on Predictive Value of Non-Invasive Atherosclerotic Measurements in Elderly Chinese

Study Overview
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Brief Summary
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The purpose of this study is to determine whether non-invasive atherosclerotic measurements (baPWV, IMT, FMD, CACS, ABI) are valuable predictors for cardiovascular events in elderly. At inception, routine physical examination and non-invasive atherosclerotic measurements will conducted on all participants. Then they will be followed prospectively for at least 2 years. All cardiovascular and other health events will be recorded.

Detailed Description
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Cardiovascular disease is the most common cause of morbidity and mortality in the world, especially in elderly. Conventional risk factors are widely used in clinical practice, but it is inadequate and inaccurate due to no direct evaluation of artery. However, invasive method, it is difficult to be applied in atherosclerosis screening and only used in advanced institutions, is expensive and unacceptable. We are trying to assess the value of noninvasive measurements in predicting cardiovascular events. Five invasive methods will be applied in the study, including brachial-ankle Pulse Wave Velocity(baPWV) Carotid Intimal-Medial Thickness(CIMT) Flow Mediated Dilation(FMD) Ankle-Brachial Index(ABI) Coronary Artery Calcification Score(CACS) These indices represent not only different phase of atherosclerosis, but also various sections and arterial layers.

Official Title
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A Prospective Study on Predictive Value of Non-Invasive Atherosclerotic Measurements in Elderly Chinese

Conditions
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Atherosclerosis, Cardiovascular Disease

Intervention / Treatment
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* Other: Cardiovascular events


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Chinese, age>=60, no gender restriction. To be able to apply the measurement mentioned above. Medical history are maintained precisely. Tianjin Medical University General Hospital is the participants' designated hospital by national health authority. Exclusion Criteria: Systemic inflammation. Malignant tumor Chronic lung disease Liver disease Aortic aneurysm

Ages Eligible for Study
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Minimum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Subgroups<br>According to the demographic features, subjects may be divided into some subgroups. | Other: Cardiovascular events<br>* Coronary intervention Infarction Congestive heart failure Stroke Cardiac death<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Atherosclerosis, Prognosis, Flow-mediated dilatation, Brachial-ankle pulse wave velocity, Carotid Intimal-Medial Thickness, coronary artery calcification score, Ankle-brachial index