Effect of General Anesthesia on Early Postoperative Cognitive Function in Cesarean Section

Study Overview
=================
Brief Summary
-----------------
Cognitive dysfunction is the impairment of the mental process of perception, memory and information processing. The preoperative cognitive state is important, as mild cognitive impairment may be worsened following a cesarean section. Our study will aim to assess the incidence of early cognitive dysfunction after elective and emergent cesarean section under general anesthesia.

Detailed Description
-----------------
Mechanisms that lead to cognitive decline after anesthesia and surgery remain still unclear and mixed. Some studies suggested that an important role is played by the immune response to surgery. The inflammatory response could contribute to the development of postoperative cognitive decline (POCD0 through secretion of cortisol, cytokines, and other inflammatory mediators. Comparing the effects of general and spinal anesthesia on pregnant patients undergoing an elective cesarean section, found no cognitive change after both anesthesias. Our observational comparative study will be carried out at Beni Suef University Hospital. We will compare early cognitive functions undergoing general anesthesia in patients undergoing elective and emergency cesarean section.

Official Title
-----------------
Effect of General Anesthesia on Early Postoperative Cognitive Dysfunction in Elective Versus Emergency Cesarean Section

Conditions
-----------------
Anesthesia Morbidity, Cesarean Section Complications

Intervention / Treatment
-----------------
* Other: Assessment document


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Women in reproductive age period between 25 and 35 years Women booked for an elective or emergency cesarean section. Exclusion Criteria: Mental disorder preoperative Medical conditions ( as Hypertension or diabetes or cardiac diseases)

Ages Eligible for Study
-----------------
Minimum Age: 25 Years
Maximum Age: 35 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| women undergoing elective CS under general anesthesia<br>Early postoperative assessment of the cognitive function of patients through evaluation document which will be filled by the anesthesiologist. | Other: Assessment document<br>* The anesthesiologist will evaluate through his sheet women's cognitive functions.<br>* Other names: Anesthesiologist evaluation sheet;|
| women undergoing emergency CS under general anesthesia<br>Early postoperative assessment of the cognitive function of patients through evaluation document which will be filled by the anesthesiologist. | Other: Assessment document<br>* The anesthesiologist will evaluate through his sheet women's cognitive functions.<br>* Other names: Anesthesiologist evaluation sheet;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| postoperative cognitive decline (POCD) | New impairment of memory directly post operative which will be assessed by psychometric questionnaire | 3 hours postoperative | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| impaired performance on intellectual tasks | New impairment of using mind in daily tasks directly post operative which will be assessed through a questionnaire | 3 days postoperative | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Cognitive function postoperative