linjc16/ctgov huggingface dataset:
Small Coronary Artery Treated by TAXUS Liberté Registry in Japan

Study Overview
=================
Brief Summary
-----------------
The utilization of paclitaxel-eluting coronary stents in small vessel diseases is effective in reducing both repeat revascularization and major adverse cardiac events within two year follow-up. To evaluate the procedural, short and long term clinical outcomes of the Taxus Liberte™ Paclitaxel-Eluting Coronary Stent in small coronary arteries of ≤ 2.5 mm in the reference vessel diameter.

Official Title
-----------------
Impact of Paclitaxel-eluting Stent for Small Coronary Artery Disease

Conditions
-----------------
Stable Angina Pectoris, Unstable Angina Pectoris

Intervention / Treatment
-----------------
* Device: TAXUS Liberté paclitaxel-eluting coronary stent system


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age ≥20 years and are able to undergo CABG Females who are not pregnant Patients who present with angina symptoms or myocardial ischemia Patients available for post-procedural observation and coronary angiography at 24 months Patients who have signed patient informed consent Lesion which is eligible for only one 2.5mm paclitaxel-eluting stent De novo lesion or non-stented restenosed lesion Exclusion Criteria: Patients contraindicated for antiplatelet therapy or anticoagulant therapy Patients with significant allergic reaction to contrast medium Chronic total occlusion Lesion with TIMI0 Lesion which is needed more than two stents Patients with chronic renal failure (SCr>3.0mg/dl) -

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 2.5mm Paclitaxel-eluting stent<br> | Device: TAXUS Liberté paclitaxel-eluting coronary stent system<br>* diameter is 2.5mm<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Target lesion revascularization rate |  | within 9months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Technical success |  | initial | 
| Target lesion revascularization rate |  | 12 months | 
| Target lesion revascularization rate |  | 24 months | 
| Target vessel revascularization rate |  | 12 months | 
| Target vessel revascularization rate |  | 24 months | 
| The rate of MACE including MI due to stent thrombosis |  | 12 months | 
| The rate of MACE including MI due to stent thrombosis |  | 24 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
TAXUS Liberté, Small coronary artery disease, Paclitaxel-eluting stent
Evaluation of a Powered Stapler System on Surgical Interventions Required During Laparoscopic Sleeve Gastrectomy

Study Overview
=================
Brief Summary
-----------------
This study will provide clinical data in an observational setting. Individuals undergoing LSG, and who meet study entry criteria, may be enrolled. LSG procedures will be performed according to institutional standard-of-care (SOC) using the study stapler. All study subjects will be followed for approximately 4 weeks for safety and outcomes.

Official Title
-----------------
Evaluation of a Powered Stapler System on Surgical Interventions Required During Laparoscopic Sleeve Gastrectomy

Conditions
-----------------
Obesity

Intervention / Treatment
-----------------
* Device: ECHELON FLEX™ Powered Plus Stapler


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Scheduled for laparoscopic sleeve gastrectomy; Subject meets NIH weight loss surgical criteria; BMI ≤ 60 kg/m2; Willing to give consent and comply with study-related evaluations; and At least 18 years of age Exclusion Criteria: Previous bariatric procedures, including gastric banding; Prior gastric surgery; Scheduled concurrent surgical procedure (hiatal hernia repair, cholecystectomy allowed); Pregnancy; Known or suspected uncontrolled bleeding disorders; History of chronic steroid use; Patients who have undergone significant upper GI surgery leading to adhesion; formation, as determined by the Principal Investigator; Physical or psychological condition which would impair study participation; The patient is judged unsuitable for study participation by the Investigator for any other reason; or Unable or unwilling to attend follow-up visits and examinations.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: ECHELON FLEX™ Powered Plus Stapler|ECHELON FLEX™ Powered Plus Stapler using ENDOPATH ECHELON™ Reloads with Gripping Surface Technology (GST). The combination of stapler plus reload is referred to as the ECHELON FLEX™ GST System.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Surgical interventions (type, quantity, frequency, rationale) required during LSG |  | Intraoperative | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Procedure duration |  | Up to one day | 
| Length of stay |  | Up to 4 weeks | 
| Estimated blood loss |  | up to one day |
Agreement Between Venous and Arterial Blood Gas Measurements in the Intensive Care Unit

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to examine the agreement between venous blood gas and arterial blood gas measurements in patients in the Intensive Care Unit.

Detailed Description
-----------------
Venous blood gas analysis may be an alternative to arterial blood gas analysis for acid-base status, reducing the need for frequent invasive arterial sampling. The objective of this study is to examine the agreement between ABG and VBG samples for all commonly used parameters (pH, pCO2 and bicarbonate) in a pathologically diverse ICU patient population, specifically analyzing multiple paired arterial and venous samples from each patient.

Official Title
-----------------
Agreement Between Venous and Arterial Blood Gas Measurements in the Intensive Care Unit

Conditions
-----------------
Acid-Base Balance

Intervention / Treatment
-----------------
* Procedure: Venous blood gas analysis


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adult patients 18 years or older Admitted to the Intensive Care Unit (ICU) Determined by their treating clinicians to require both a central venous line and arterial line Exclusion Criteria: None

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: 1<br> | Procedure: Venous blood gas analysis<br>* When an ABG is deemed to be necessary as part of ICU management, a central venous sample will also be obtained with minimum delay (always < 2 minutes) between the samples. The samples will be analyzed by a blood gas analyzer as quickly as possible.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Agreement between venous and arterial blood gas measurements of pH, pCO2 and bicarbonate |  | Duration of Intensive Care Unit Admission | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Venous blood gas, Arterial blood gas, pH, pCO2, Bicarbonate
Development of Human Laboratory Study Model of Cocaine Relapse Prevention II - 1

Study Overview
=================
Brief Summary
-----------------
To study of classical conditioning mechanisms associated with arousal, craving and cocaine use.

Detailed Description
-----------------
This is a single-site, double-blind, placebo-controlled crossover study of classical conditioning mechanisms associated with arousal, craving and cocaine use.

Official Title
-----------------
Cocaine Relapse Prevention II

Conditions
-----------------
Cocaine-Related Disorders

Intervention / Treatment
-----------------
* Drug: Cocaine (IV)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Be English-speaking volunteers who are cocaine dependent Be non-treatment seeking at the time of the study Meet DSM-IV criteria for cocaine dependence Have ECG showing normal sinus rhythm, normal conductivity, and non clinically significant arrhythmias Females must provide a negative pregnancy test and agree to use birth control Have baseline laboratory tests within normal limits Exclusion Criteria: Please contact site for more information

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Cocaine (IV)|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Stimulated and non-stimulated craving |  |  | 
| Cocaine assessment |  |  |
Correlation Between Altered Glycometabolic Status and Joint Inflammation in Diabetic Patients With Osteoarthritis Undergoing Knee Arthroplasty

Study Overview
=================
Brief Summary
-----------------
Evaluate the correlation between altered glycometabolic status and joint inflammation in diabetic patients with osteoarthritis undergoing knee replacement surgery

Official Title
-----------------
Correlation Between Altered Glycometabolic Status and Joint Inflammation in Diabetic Patients With Osteoarthritis Undergoing Knee Arthroplasty

Conditions
-----------------
To Evaluate a Linear Positive Correlation Between Plasma HbA1c and Synovial IL-6 in Diabetic Patients

Intervention / Treatment
-----------------
* Diagnostic Test: Evaluation of Synovial IL-6 in diabetic patients with gonarthrosis


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diabetic patients Patients with osteoarthritis awaiting knee replacement surgery Patients awaiting knee replacement surgery Patients who agree to sign informed consent Exclusion Criteria: Patients less than 55 years of age. Patients over 85 years of age. Patients who are unable to understand and want. Patients with severe neurological disorders or with severe disabilities. Rheumatoid arthritis patients Cancer patients Patients suffering from chronic inflammatory bowel syndromes (RCU and Crohn's disease) Patients on immunosuppressive therapy

Ages Eligible for Study
-----------------
Minimum Age: 55 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: Evaluation of Synovial IL-6 in diabetic patients with gonarthrosis|To evaluate if there is a linear positive correlation between plasma glycated hemoglobin concentration HbA1c and synovial IL-6 in diabetic patients|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To evaluate if there is a linear positive correlation between plasma glycated hemoglobin concentration HbA1c and synovial IL-6 in diabetic patient | To evaluate if there is a linear positive correlation between plasma glycated hemoglobin concentration HbA1c and synovial IL-6 in diabetic patient | 2 day |
Transesophageal Echocardiography in Embolic Stroke of Undetermined Source

Study Overview
=================
Brief Summary
-----------------
The ESUS concept was introduced recently to describe a non-lacunar stroke of undetermined etiology. The following etiological workup is required in this setting: head CT or MRI, 12-lead ECG, transthoracic echocardiography, continuous cardiac monitoring for at least 24 hours after stroke, vascular imaging (ultrasound, magnetic resonance angiography, CT angiography, catheter angiography). Transesophageal echocardiography (TEE) is considered not to be required. However, aortic arch atheroma as diagnosed by TEE in the setting of recent ischemic stroke is a major aortic source of embolism, as supported by numerous well conducted studies. The European Association of Echocardiography considers that TEE is the gold standard for the diagnosis and the characterization of aortic atheroma. It is also the method of choice for the diagnosis of infectious endocarditis. The aim of this work was to evaluate the rate of patients with a therapeutic modification induced by TEE (mainly anticoagulation and surgery), in consecutive patients admitted with ESUS at our institution stroke unit.

Official Title
-----------------
Therapeutic Implications of Early Transesophageal Echocardiography in Embolic Stroke of Undetermined Source (ESUS)

Conditions
-----------------
Embolic Stroke of Undetermined Source, Ischemic Stroke

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Presenting with a new onset of ischemic stroke Meeting the ESUS criteria (Embolic Stroke of Undetermined Source) Comprehensive transthoracic echo prior to the TEE Exclusion Criteria: ESUS criteria not met Contraindications to TEE TEE failure Pregnant or breastfeeding woman Person under legal protection No medical insurance coverage

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| therapeutic modification after transesophageal echocardiography | proportion of patients with a therapeutic modification (mainly anticoagulation and surgery) | 24 hours after TEE | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Embolic Stroke of Undetermined Source, transesophageal echocardiography, cardiac source of embolism, ischemic stroke
Postoperative Relapses in MS Patients

Study Overview
=================
Brief Summary
-----------------
The aim of the study is to record any relapses during one year postoperatively in patients and parturients diagnosed with MS who received general or regional anesthesia

Official Title
-----------------
Assessment of Risk of Postoperative Relapses in Patients With Multiple Sclerosis; an Observational Study

Conditions
-----------------
Multiple Sclerosis Relapse, Surgery, Anesthesia

Intervention / Treatment
-----------------
* Procedure: surgery and anesthesia


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: diagnosed MS - Exclusion Criteria: refuse to participate -

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| regional anesthesia<br> | Procedure: surgery and anesthesia<br>* patients with MS who received general or regional anesthesia for a surgery or labor<br>|
| general anesthesia<br> | Procedure: surgery and anesthesia<br>* patients with MS who received general or regional anesthesia for a surgery or labor<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| MS relapses | number of relapses | one year postoperatively |
Cotton Sock in Pediatric Patients With Leg-foot Splint

Study Overview
=================
Brief Summary
-----------------
The post-operative treatment of pediatric patients operated for the correction of flat foot, sees today the use of preformed leg-foot splint (Walker) as an alternative to the application of plaster casts. The change of the immobilization system has led to the appearance of problems of tolerability in particular in the skin. The problems persist also after placing a polyurethane foam dress at the heel in the immediate postoperative period. The aim of this study is to evaluate the effectiveness of a cotton sock applied inside the leg-foot splint in children operated vs the Elastic Compression Wraps in reducing the incidence of cutaneous lesions.

Official Title
-----------------
Effectiveness of Cotton Sock in Pediatric Patients With Leg-foot Splint After Surgery for Correction of the Foot, in Reducing the Incidence of Cutaneous Lesions. Randomized Controlled Trial.

Conditions
-----------------
Flat Foot

Intervention / Treatment
-----------------
* Other: cotton sock
* Other: Elastic Compression Wraps


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Children aged > 3 years Treated for flat foot Children with intact skin at the heel Exclusion Criteria: Caregivers who cannot speak Italian Those who refuse to give their consent to take part in the study Patients with lower limb casts

Ages Eligible for Study
-----------------
Minimum Age: 4 Years
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: cotton sock<br> | Other: cotton sock<br>* Application of a cotton sock in the immediate postoperative period before applied the Walker<br>|
| Active Comparator: Elastic Compression Wraps<br> | Other: Elastic Compression Wraps<br>* Application of an Elastic Compression Wraps in the lower limb in the immediate postoperative period before applied the Walker (standard care)<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Heel Pressure Sores | • Numbers of Participants With Heel Pressure Sores of all grade Detected According to the Classification of the Scale of the National Pressure Ulcer Advisory Panel -N.P.U.A.P. | every day until discharge (expected average of 3 days). | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain | Pain Score on the Numeric Rating Scale | up to the first 3 days post intervention |
Application of Circulating Exosomes in Early Diagnosis and Prognosis Evaluation After Intracerebral Hemorrhage

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to observe the relationship between the changes of circulating exosomes and the development and outcome of the disease in patients with intracerebral hemorrhage, and to search for early serum markers and potential intervention targets for disease monitoring in patients with intracerebral hemorrhage

Official Title
-----------------
Application of Circulating Exosomes in Early Diagnosis and Prognosis Evaluation After Intracerebral Hemorrhage

Conditions
-----------------
Intracerebral Hemorrhage；Circulating Exosomes

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: No systematic treatment was given before admission; The patients were diagnosed with cerebral hemorrhage, and had imaging evidence; The age was more than 18 years old; The patient or family member agrees to sign the informed consent. Exclusion Criteria: Hematoma is caused by secondary factors (intracranial tumor, arteriovenous malformation or aneurysm); Bleeding into the ventricle; Multiple cerebral hemorrhage; The patient did not receive treatment in our hospital; Severe disability, dementia, or organ dysfunction before onset Coagulopathy or long-term use of anticoagulants Hematoma affects brain stem Subjects refused to participate

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The type and content of circulating exosomes | After the exosomes were isolated, RNA sequencing and proteome sequencing were performed to identify the change of circulating exosomes | within 24 hours of ICH | 
| Modified Rankin scale (mRS) scores | mRS scores was divided into seven grades (0-6). The higher the score, the more severe the symptoms | from onset to three months or six months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| mortality |  | through study completion，an average of 1 year | 
| hospital stay |  | From hospitalization to discharge，up to one month |