Efficacy and Mechanisms of Mobile-Delivered Alcohol Attentional Bias Modification

Study Overview
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Brief Summary
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This study evaluates the efficacy as well as psychological and neurobiological mechanisms of mobile-delivered alcohol attentional bias modification among heavy drinking adults.

Detailed Description
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By testing the efficacy and neurobiological mechanisms of behavior change (MOBC) following attentional bias modification among heavy drinking adults, the proposed study has the potential to unify dual process models and neurobiological models of addiction. The cognitive retraining will be delivered via mobile electronic devices to ensure the cost-effectiveness of these procedures, to allow a large amount of retraining to be delivered in an ecologically valid manner, and to facilitate broad dissemination of such procedures if found to be efficacious. Using an intensive longitudinal experimental design, subjects will be randomly assigned into one of 2 groups (attentional bias modification vs. attentional bias control). Ecological momentary assessment (EMA) data will be used to assess changes in cognitive and behavioral measures in situ, and functional magnetic resonance imaging (fMRI) scans before and after cognitive retraining will be used to examine neural changes in specific regions of interest (ROI).

Official Title
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Efficacy and Mechanisms of Mobile-Delivered Alcohol Attentional Bias Modification

Conditions
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Alcohol; Harmful Use

Intervention / Treatment
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* Behavioral: Attentional Bias Modification


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Alcohol Use Disorders Identification Test greater than or equal to 8 right-handed Exclusion Criteria: history of treatment for or diagnosis of alcohol use disorder/substance use disorder history of brain injury for females, currently pregnant any MRI safety contraindication

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Attentional Bias Modification<br>Participants complete attentional bias modification using a dot probe task on a mobile device up to 5 times per day for a 28-day period (80 trials per assessment). | Behavioral: Attentional Bias Modification<br>* Mobile-Delivered Cognitive Retraining Intervention<br>* Other names: Cognitive Retraining;|
| No Intervention: Attentional Bias Control<br>Participants complete attentional bias assessment-only using a dot probe task on a mobile device up to 5 times per day for a 28-day period (80 trials per assessment). | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Alcohol Use Frequency | Number of days of alcohol use during the 4-week ecological momentary assessment period | 4 weeks | 
| Alcohol Use Quantity | Number of standard drinks per day during the 4-week ecological momentary assessment period | 4 weeks | 
| Negative Alcohol-Related Consequences | Number negative consequences experienced 4-week ecological momentary assessment period | 4 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Attentional Bias to Alcohol | Measured with the Alcohol Dot Probe Task | 4 weeks | 
| Alcohol Cue-Induced Neural Reward Circuit Activation | Regions of interest include ventral tegmental area, dorsal and ventral striatum | 4 weeks |