Capsaicin on Salty Gustatory Cortices

Study Overview
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Brief Summary
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Excess dietary salt intake is closely associated with the development of hypertension and cardiocerebral vascular diseases. Preference of high salt diet might involve salty gustatory cortices change. This study focuses on examining the neuroimaging changes of salty gustatory cortices under different concentration of NaCl solution with or without capsaicin intervention through brain PET/CT scan.

Detailed Description
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Hypertension and its related complications are common health problems that can lead to multiple organ damage and death. Excessive salt intake plays an important role in the development of hypertension. The experimental design is a randomized, double-blind, interventional study to investigate the neuroimaging changes of salty gustatory cortices under different concentration of NaCl solution with or without capsaicin intervention through brain PET/CT scan.

Official Title
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Effects of Capsaicin on Salty Gustatory Cortices in Human

Conditions
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Volunteers

Intervention / Treatment
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* Dietary Supplement: Capsaicin
* Dietary Supplement: NaCl


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age ≥ 18 years and ≤ 65 years. Willing and able to provide written informed consent. Willing and able to comply with all study procedures. Exclusion Criteria: High basic metabolic rate, tumor, epilepsia. Hypogeusia or loss due to neural system disease or oral and digestive disease. Capsaicin allergy and poor compliance. Recently oral diuretics and participate in other pharmacological experiment in 3 months. Acute infection, cancer, serious arrhythmias, drug or alcohol abuse. Currently have cold, fever, acidosis, dehydration, diarrhea, vomiting during the study. Unwilling or unable to communication due to the dysnoesia and language disorders. Severe neural or psychiatric diseases that would preclude fully understand and corporation in the study. History of allergic reaction attributed to 18F-FDG. Pregnancy or lactation.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Capsaicin_effect subgroup 1<br>The volunteers allocated to the arm will perform neuroimaging detection with buccal administration of water with capsaicin. | Dietary Supplement: Capsaicin<br>* Capsaicin in the concentration of 0.5 µmol/L was mixed in the test solutions in Capsaicin_effect subgroups<br>|
| Experimental: Capsaicin_effect subgroup 2<br>The volunteers allocated to the arm will perform neuroimaging detection with buccal administration of 100 mmol/L NaCl with capsaicin. | Dietary Supplement: Capsaicin<br>* Capsaicin in the concentration of 0.5 µmol/L was mixed in the test solutions in Capsaicin_effect subgroups<br>|
| Experimental: Capsaicin_effect subgroup 3<br>The volunteers allocated to the arm will perform neuroimaging detection with buccal administration of 150 mmol/L NaCl with capsaicin. | Dietary Supplement: Capsaicin<br>* Capsaicin in the concentration of 0.5 µmol/L was mixed in the test solutions in Capsaicin_effect subgroups<br>|
| No Intervention: Capsaicin_effect subgroup 4<br>The volunteers allocated to the arm will perform neuroimaging detection with buccal administration of 200 mmol/L NaCl. | |
| No Intervention: Salt_effect subgroup 1<br>The volunteers allocated to the arm will perform neuroimaging detection with buccal administration of water. | |
| Experimental: Salt_effect subgroup 2<br>The volunteers allocated to the arm will perform neuroimaging detection with buccal administration of 100 mmol/L NaCl. | Dietary Supplement: NaCl<br>* NaCl in various concentrations was desorved in the test solutions in Salt_effect subgroups<br>|
| Experimental: Salt_effect subgroup 3<br>The volunteers allocated to the arm will perform neuroimaging detection with buccal administration of 150 mmol/L NaCl. | Dietary Supplement: NaCl<br>* NaCl in various concentrations was desorved in the test solutions in Salt_effect subgroups<br>|
| Experimental: Salt_effect subgroup 4<br>The volunteers allocated to the arm will perform neuroimaging detection with buccal administration of 200 mmol/L NaCl. | Dietary Supplement: NaCl<br>* NaCl in various concentrations was desorved in the test solutions in Salt_effect subgroups<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Neuroimaging changes of salty gustatory cortices | Buccal administration of test solution for five mins, and PET/CT scan after 40 mins | 45min |