Atrial Fibrillation Patients Treated With Catheter Ablation

Study Overview
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Brief Summary
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This is a single-center prospective observational cohort study of atrial fibrillation patients treated with radiofrequency ablation.

Detailed Description
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The effect of radiofrequency therapy on the life quality and atrial function of atrial fibrillation patients will be assessed, through the multidimensional analysis of baseline clinical data, serological indicators of atrial fibrosis, echocardiography, cardiac magnetic resonance imaging, atrial potential mapping, life quality, and long-term ECG monitoring within 1 week after radiofrequency ablation. A predictive model for atrial fibrillation recurrence after ablation will be established. Based on the cross-sectional analysis of baseline data, the relationship between non-invasive assessment of atrial fibrosis (imaging and serology), atrial electrical activity, and atrial function will be analyzed as well, and atrial fibrillation patients with ventricular fibrosis will be selected for gene sequencing to explore the existence of underlying cardiomyopathy and provide data for further research.

Official Title
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A Prospective Cohort Study of Atrial Fibrillation Patients Treated With Catheter Ablation

Conditions
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Atrial Fibrillation, Atrial Fibrillation Recurrent

Intervention / Treatment
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* Procedure: radiofrequency ablation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Non-valvular atrial fibrillation, including paroxysmal atrial fibrillation and persistent atrial fibrillation 18-80 years old The anteroposterior diameter of the left atrium is less than 50mm via TTE Patient meets the intervention criteria for bilateral pulmonary vein isolation after evaluation by electrophysiological specialists Patient consents to ablation treatment Exclusion Criteria: Intra-atrial thrombus detected by TEE Hyperthyroidism Previous radiofrequency ablation for atrial fibrillation

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| atrial fibrillation<br>Atrial fibrillation patients who underwent radiofrequency ablation in Peking Union Medical College Hospital. | Procedure: radiofrequency ablation<br>* Bilateral pulmonary vein isolation, a kind of radiofrequency ablation, is performed in atrial fibrillation patients for atrial arrhythmia therapy.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Recurrence assessed by ECG, Holter reports and outpatient physicians | Recurrence includes atrial fibrillation and atrial flutter. Recurrence features including pattern, duration, burden, etc. will be recorded. | at 1-year follow-up after ablation | 
| All-cause mortality assessed by telephone follow-up or medical records | Time and cause of death will be recorded. | at 1-year follow-up after ablation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Improvement in life quality assessed by QOLSF36 Questionnaire | Life quality will be assessed at baseline and 1-year FU. Improvement in life quality indicates that patients can benefit from the catheter ablation. | at 1-year follow-up after ablation | 
| Improvement in left atrial function assessed by echocardiography | Left atrial function will be assessed at baseline and 1-year FU. Improvement in atrial function indicates that ablation can restore atrial function. | at 1-year follow-up after ablation | 
| Embolic events assessed by physicians and further examinations like ultrasound, MRI | Embolism may be related to atrial fibrillation. Embolism will be assessed by physicians according to patients' symptoms and signs at clinic or by telephone. If a patient's clinical presentation indicates embolism, the patient will be further assessed by ultrasound, MRI, etc. | at 1-year follow-up after ablation | 
| Hospitalization for heart failure, atrial fibrillation or atrial flutter | Postoperative hospitalization indicate worse prognosis. | at 1-year follow-up after ablation |