The Effects of Different Ways of Dressing Central Line Associated Bloodstream Infections

Study Overview
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Brief Summary
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The goal of our study was to investigate whether different methods of dressing could lower catheter-associated bloodstream infections.

Detailed Description
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The study method was experimental in design and recruited 331 medical intensive care unit patients with placement of central catheters in one regional hospital in northern Taiwan. The investigators used block randomization to assign patients to the study group or control group. In study group which included 163 participants, the investigators used aseptic coverings during dressing and in the control group which included 168 participants the process of dressing was as routine. Study period started from the first day of catheter insertion and ends with either the removal of catheter or discharge from intensive care unit. The investigators defined the infection outcome according to culture results, and the guidelines by Infectious Diseases Society of America and Centers for Disease Control and Prevention, USA. Analysis was done by SPSS version 23. The investigators used percentage and average to study characteristics of participants. The investigators used Chi-Square or Fisher's exact test and Poisson distribution to analyze the incidence rate of bloodstream infections and the infection density. The investigators used Kaplan-Meier curve to demonstrate the catheter infection-free days and the catheter redness symptoms days of the two groups. The investigators used logistic regression model to analyze factors associated with development of bloodstream infections.

Official Title
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The Effects of Different Ways of Dressing Central Line Associated Bloodstream Infections

Conditions
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Central Line-associated Bloodstream Infection (CLABSI)

Intervention / Treatment
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* Other: full aseptic dressing


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adults older than 20 years old Patients with central venous catheters Agree to participate in this study, and fill out the study consent Exclusion Criteria: PICC patients placed Patients with bloodstream infection Patients with immunocompromised patients (such as HIV, AIDS, pregnant, or cancer patients who are receiving chemotherapy or radiotherapy)

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: full sterile dressing<br>Patients receive full sterile dressing | Other: full aseptic dressing<br>* Replacement of the central venous catheters in the dressing process<br>|
| No Intervention: usual standard care<br>Patients receive usual standard care | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Catheter-related blood stream infections density after dressing change | Confirm blood culture results and judge whether it is catheter related Bloodstream infection(CRBSI) | up to 18 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Central Line-Associated Bloodstream Infection density after dressing change | Confirm blood culture results and judge whether it is catheter related Bloodstream infection, CLABSI | up to 18 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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CRBSI, CLABSI