Dual Site-Dual Channel Non-invasive Brain Stimulation for Motor Function in Healthy Subjects

Study Overview
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Brief Summary
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The aim of this study is to investigate the effect of dual site-dual channel non-invasive brain stimulation for recovery of motor function in healthy subjects. Simultaneous dual site-dual channel stimulation was applied by using two sets of transcranial direct current stimulation devices. All subjects will go through four conditions of transcranial direct current stimulation with for 30 minutes. Four conditions are 1) Dual stimulation: i) anodal stimulation on right primary motor cortex and cathodal stimulation on left primary motor cortex, ii) anodal stimulation on right premotor cortex and cathodal stimulation on left supraorbital area. 2) M1 stimulation: anodal stimulation on right primary motor cortex and cathodal stimulation on left primary motor cortex; 3) PMC stimulation: anodal stimulation on right premotor cortex and cathodal stimulation on left supraorbital area. 4) sham stimulation

Official Title
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Effect of Dual Site-Dual Channel Non-invasive Brain Stimulation for Recovery of Motor Function in Healthy Subjects

Conditions
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Healthy

Intervention / Treatment
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* Device: M1 stimulation
* Device: PMC stimulation
* Device: Sham stimulation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: healthy subjects with age over 19 years old Exclusion Criteria: history of disorders involving central nervous system patients with severe medial or psychiatric disease

Ages Eligible for Study
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Minimum Age: 19 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Dual stimulation<br>anodal stimulation on right primary motor cortex and cathodal stimulation on left primary motor cortex anodal stimulation on right premotor cortex and cathodal stimulation on left supraorbital area | Device: M1 stimulation<br>* stimulating primary motor cortex with anodal stimulation on right primary motor cortex and cathodal stimulation on left primary motor cortex<br>|
| Experimental: M1 stimulation<br>anodal stimulation on right primary motor cortex and cathodal stimulation on left primary motor cortex | Device: M1 stimulation<br>* stimulating primary motor cortex with anodal stimulation on right primary motor cortex and cathodal stimulation on left primary motor cortex<br>|
| Experimental: PMC stimulation<br>anodal stimulation on right premotor cortex and cathodal stimulation on left supraorbital area | Device: PMC stimulation<br>* stimulating premotor cortex with anodal stimulation on right premotor cortex and cathodal stimulation on left supraorbital area<br>|
| Sham Comparator: Sham stimulation<br>Sham stimulation | Device: Sham stimulation<br>* sham stimulation over both primary motor cortex and premotor cortex<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in motor evoked potential | measure the motor threshold and amplitude of motor evoked potential in first dorsal interosseous muscle | Baseline and after intervention (approximately 30 minutes) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in sequential motor task | measures motor functional and dexterity of hand | Baseline and after intervention (approximately 30 minutes) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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transcranial direct current stimulation, motor function