Silent Ureteral Stone: Impact on Renal Function and Kidney Anatomy

Study Overview
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Brief Summary
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Ureteral stones may be silent in 5.3% of patients. The goal of this study was to prospectively evaluate the impact of a silent ureteral stone on renal function.

Detailed Description
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The prevalence of nephrolithiasis is increasing worldwide, reaching 5.2% in North America and 10.1% in Italy. The widespread use of computed tomography and ultrasonography have resulted in a greater detection rate of asymptomatic stones and, in part, might explain the trend. Clinically, kidney or ureteral stones range in severity from asymptomatic to presenting with complete renal failure. Therefore, it is not only the alarming incidence of urinary stone disease, but also the associated burden that makes this one of the most concerning conditions in public health. The situation becomes even more distressing when managing asymptomatic stones. Studies of the natural history of stones have revealed that only 20% of patients yearly actually become symptomatic from a new stone, and one half of those require surgical intervention at some point. The guidelines are well established for the treatment of symptomatic urolithiasis, and many investigators have extensively studied the management of silent kidney stones. Conversely, the same is not true for silent ureterolithiasis. The purpose of the present study is to report the investigators experience managing silent ureteral stones and to prospectively analyze their true influence on renal function.

Official Title
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The Impact of Silent Ureteral Stone on Renal Function and Kidney Anatomy: a Prospective Analysis

Conditions
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Urinary Calculi

Intervention / Treatment
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* Procedure: Surgical Treatment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Silent ureteral stone: no subjective/objective symptoms related to the ureteral calculi. Patient willing to participate in the study Complete pre/post-operative work-up Exclusion Criteria: Treatment outside our institution No will to be a part of the study Incomplete pre/post-operative work-up

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Surgical Treatment<br>Silent Ureteral Stone - Surgical Treatment | Procedure: Surgical Treatment<br>* Surgical Treatment - open, endoscopic or laparoscopic<br>* Other names: Surgical Treatment - open, endoscopic or laparoscopic;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ipsilateral Renal Function | Ipsilateral renal function determined by dimercaptosuccinic acid scintigraphy (DMSA) 12 months after surgery. | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Serum Creatinine level | Serum Creatinine level | 1 year | 
| Estimated Creatinine Clearance | Estimated Creatinine Clearance | 1 year | 
| Renal Anatomy assessed by Ultrasound | Renal Anatomy assessed by Ultrasound | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Asymptomatic, ureteral, calculi, renal function, treatment