S1119 Peruvian H. Pylori Water Contamination Study

Study Overview
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Brief Summary
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The objective of this study is to elucidate the role of drinking water derived from the public source in Lima, Peru and transmission of H. pylori infection using genotypic techniques.

Detailed Description
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The objective of this study is to detect the presence of Helicobacter Pylori in the drinking water derived from the public network by molecular and genomic techniques in districts of Lima (Brena, Chorrillos, Comas, El Agustino, La Victoria, Lince, Los Olivos, Miraflores, Puente Piedra, Rimac, San Isidro, San Juan de Lurigancho, San Martin de Porres, Villa El Salvador, and Villa Maria del Triunfo) with high and low incidence of gastric carcinoma. The secondary objective of this study is to establish correlations between the findings in water and those of the stomach of patients with symptoms of dyspepsia who live in those districts.

Official Title
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Gastric Cancer and Helicobacter Pylori Infection in Lima, Peru: The Role of Water Contamination

Conditions
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Helicobacter Pylori Infection

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: adults between the ages of 21-70 years old who have lived for more than 10 years in the Lima districts listed in protocol, who have a biopsy proven diagnosis of infection by H. pylori. participants must be in good general condition, mentally competent and able to provide informed consent; must not show evidence of dehydration or jaundice; must be willing to complete the patient questionnaires. participants must not have known allergies to any of the antibiotics used in the study. Exclusion Criteria: pregnancy

Ages Eligible for Study
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Minimum Age: 21 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| biopsy proven H. pylori<br>Patient must have lived in the districts of Lima, Peru listed in the protocol. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Detect H. pylori in public drinking water of Lima Peru | To detect the presence of Helicobacter Pylori (H. pylori) in the drinking water derived from the public network by molecular and genomic techniques in districts of Lima, Peru (districts detailed in protocol). | within 1 year of receving last sample | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation of H. pylori in water and those of stomachs of patients with symptoms | To establish correlations between the findings in water and those of the stomach of patients with symptoms of dyspepsia who live in those districts. | Within 1 year of receiving last sample | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Helicobacter pylori, water contamination, Lima, Peru