Predicting Relapse After Cocaine Inpatient Cessation

Study Overview
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Brief Summary
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Can brain MRI at entry of cocaine inpatient cessation attempt predict relapse during a three month follow-up ? Hypothesis : White matter losses in the prefrontal cortex are associated with relapse to cocaine use.

Detailed Description
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A multivariate model using MRI parameters, craving score, impulsivity score, and neuropsychological testing results will be tested to predict relapse or continuous abstinence three month after cocaine inpatient cessation attempt.

Official Title
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Prospective Prediction of Cocaine Relapse After Inpatient Cessation by Combining Functional Imaging and Neuropsychological Biomarkers With Craving and Impulsivity Measures

Conditions
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Cocaine Dependence, Cocaine Use Disorder

Intervention / Treatment
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* Procedure: Brain MRI imagery


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: cocaine dependent patient requiring inpatient cessation 18 years old and older giving his/her consent to come back for visits up to three months having a social insurance Exclusion Criteria: minor under guardianship restraint hospitalization contraindication to brain MRI pregnant women

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Brain MRI imagery|Brain MRI performed during the first week of inpatient cocaine cessation|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| mean difference of fractional anisotropy of the prefrontal cortex (PFC) in patients abstinent from cocaine 3 months after inpatient detoxification compared to relapsers |  | at 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparisons between patients who remain abstinent from cocaine 3 months after inpatient detoxification and those who relapse | Differences in grey and white matter volumes : voxel-based morphometry (VBM) and in resting-state whole-brain activity default mode network (DMN) | at baseline | 
| Comparisons between patients who remain abstinent from cocaine 3 months after inpatient detoxification and those who relapse | Differences in scores of craving (visual scale and Obsessive compusilve craving scale (OCCS) questionnaire) and impulsivity (UPPS) | at baseline | 
| Comparisons between patients who remain abstinent from cocaine 3 months after inpatient detoxification and those who relapse | Differences in performance at the stroop test and in mental flexibility during an implicit set shifting task | at baseline | 
| Among abstinent patients who remain abstinent at three months only :Differences between baseline and 3 months measures of Diffusion Tensor Imagery (DTI), VBM and DMN |  | at 3 months | 
| Among abstinent patients who remain abstinent at three months only: Differences in scores of craving (visual scale and OCCS questionnaire) and impulsivity (UPPS) |  | at 3 months | 
| Among abstinent patients who remain abstinent at three months only: Differences in performance at the stroop test and in mental flexibility during an implicit set shifting task compared to baseline results |  | at 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cocaine, Dependence, Abstinence, Prediction, Model, Humans, MRI, Cognitive, Impulsivity, Craving