Improving Health and Reducing Disability of Depressed Elderly With Chronic Conditions Through Qigong Exercise

Study Overview
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Brief Summary
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Qigong exercise is beneficial for older adults with co-occurring chronic physical illness and depression in terms of psychological and physical outcomes. However, the effects on functional independence, sleep quality, and mobility of depressive older adults remain unclear. It is also important to replicate its benefits for subjective well-being and muscle strength. A randomized clinical trial was conducted among older adults who were aged 60 or above and with chronic medical conditions for one year. After random assignment, intervention group (n = 25) went through qigong exercise twice a week and for 12 weeks,whereas control group (n = 22) was involved in cognitive training activities with mobilization elements. The psychosocial and physical outcomes of the two groups were compared.

Official Title
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Improving Health and Reducing Disability of Depressed Elderly With Chronic Conditions Through Qigong Exercise: A Randomized Controlled Trial

Conditions
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Chronic Disease, Depressive Symptoms

Intervention / Treatment
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* Behavioral: Qigong Training
* Behavioral: Cognitive Training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: aged 60 or above have been suffering from chronic medical conditions for more than one year have depressive symptoms as indicated by Geriatric Depression Scale (GDS ≥ 6) Exclusion Criteria: have practiced or received training of any form of mind-body exercises (including tai chi, yoga, and qigong) during the 6 months prior to intervention. have changed medication or the dosage prior to or during intervention have obvious cognitive and language impairment or score less than 20 in Mini-Mental State Examination (MMSE) undergo electroconvulsive therapy, psychotherapy, or psychoeducation cannot demonstrate satisfactory sitting balance

Ages Eligible for Study
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Minimum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Qigong Training<br> | Behavioral: Qigong Training<br>* Eight-Section Brocades<br>|
| Active Comparator: Cognitive Training<br> | Behavioral: Cognitive Training<br>* Cognitive Training of Memory and Executive Function with Activities requiring Mobilization<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Personal Well-Being Index (PWI) | It is measured by the 8-item scale of Personal Well-Being Index (PWI). Each item was rated according to an 11-point scale ranging from '0' (extremely dissatisfied) to '10' (extremely satisfied). An overall score of PWI score was the sum of all items. The overall score ranges from 0 to 110, with higher score indicating higher subjective well-being. | the change from baseline to the completion of intervention (12 weeks later) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Functional Independence Measure (FIM) | It is measured by the 18-item scale of Functional Independence Measure (FIM). Based on a 7-point scale for rating (1 = totally unable; 7 = totally independent), a total score of FIM ranges from 18 to 126 was generated. Higher total score indicates less disability. | baseline, 12 weeks after baseline, and 16 weeks after baseline | 
| Pittsburgh Sleep Quality Index (PSQI) | It is measured by the Pittsburgh Sleep Quality Index (PSQI). It has 19 items measuring 7 components of sleep quality, and a total score is calculated as the sum of all the component scores. The total score ranges from 0 to 21, with lower score showing better sleep quality. | baseline, 12 weeks after baseline, and 16 weeks after baseline | 
| Timed up and Go Test (TUG) | Timed up and Go Test (TUG) is used to measure mobility. During the test, participants were sitting on a chair, and then they were required to stand up, walk to a mark which is 3 meters away from the chair, go back to the chair from the mark, and sit down again. The time each participant spent to complete the above series of actions was recorded. Participants performed the test for three times, and their final scores were the average of the three. And lower score indicates better mobility. | baseline, 12 weeks after baseline, and 16 weeks after baseline | 
| Handgrip Strength | It is measured with a Jamar handheld dynamometer. Participants performed three trials of left hand and right hand grip strength, and the final outcome of each hand was calculated as the mean performance of the three trials. Higher score indicates stronger handgrip strength. | baseline, 12 weeks after baseline, and 16 weeks after baseline |