Optical Coherence Tomography of the Airway for Lung Cancer or Lung Disease

Study Overview
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Brief Summary
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RATIONALE: Diagnostic procedures, such as optical coherence tomography, may help find and diagnose lung cancer or precancerous cells. PURPOSE: This phase I trial is studying how well optical coherence tomography of the airway works in detecting abnormal cells in patients undergoing surgery for lung cancer or lung disease.

Detailed Description
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OBJECTIVES: Correlate optical coherence tomography images of the airway with airway histology. Develop an imaging technique to detect premalignant airway epithelial changes (carcinoma in situ, dysplasia) to study the transformation process as well as intervene and prevent the development of lung cancer. OUTLINE: Bronchoscopic imaging and optical coherence tomography are performed on lung tissue samples collected during surgery. All imaged areas are marked. The marked areas are then excised and fixed in formalin for histopathologic analysis.

Official Title
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Optical Coherence Tomography of Human Airways

Conditions
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Lung Cancer, Malignant Mesothelioma, Metastatic Cancer, Nonmalignant Neoplasm, Precancerous Condition

Intervention / Treatment
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* Procedure: bronchoscopic and lung imaging studies
* Procedure: diagnostic bronchoscopy
* Procedure: histopathologic examination
* Procedure: optical coherence tomography


Participation Criteria
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Eligibility Criteria
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DISEASE CHARACTERISTICS: Undergoing pneumonectomy or lobectomy for malignant or benign lung processes PATIENT CHARACTERISTICS: Not specified PRIOR CONCURRENT THERAPY: See Disease Characteristics
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: bronchoscopic and lung imaging studies|Bronchoscopic imaging and optical coherence tomography are performed on lung tissue samples collected during surgery.|
|Procedure: diagnostic bronchoscopy|Bronchoscopic imaging and optical coherence tomography are performed on lung tissue samples collected during surgery.|
|Procedure: histopathologic examination|All imaged areas are marked. The marked areas are then excised and fixed in formalin for histopathologic analysis.|
|Procedure: optical coherence tomography|Bronchoscopic imaging and optical coherence tomography are performed on lung tissue samples collected during surgery.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation of optical coherence tomography images of the airway with airway histology |  | This study will involve discarded tissue from 10 subjects with pathology specimens over one year. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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non-small cell lung cancer, small cell lung cancer, benign respiratory tract neoplasm, lung papilloma, recurrent respiratory papillomatosis, squamous lung dysplasia, malignant mesothelioma, pulmonary carcinoid tumor, lung metastases