Veno-arterial Extracorporeal Membrane Oxygenation Prior to Left Ventricular Assist Device Implantation.

Study Overview
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Brief Summary
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Cardiogenic shock is an uncommun pathology with a high mortatily rate around 45%. Veno arterial extracorporeal membrane oxygenation (VA-ECMO) is a temporary extracorporeal assist device which restore an adequate blood flow when a circulatory failure occures. VA-ECMO main indication is refractory cardiogenic shock whatever the etiology. Current medical care of terminal cardiac failure includes use of long-term mechanical circulatory support devices (MCSD) such as Left Ventricular Assist Device (LVAD). LVAD therapy may lead to heart transplant (bridge to transplantation), to recovery (bridge to recovery) or to permanent implantation (destination therapy). Few patients with refractory cardiogenic shock treated with VA-ECMO may secondarily need a long term MCSD with LVAD. LVAD long-term heart assist showed interesting survival rate when implantation occured (71% after 2 years follow-up and 45% after 4 years follow-up) out of acute heart failure situation. There are only few datas concerning LVAD implantion during refractory cardiogenic shock, with a mortality between 20 to 50% in different studies. In this way, in comparaison of current few datas on the subject of LVAD implantation under VA-ECMO, the investigators (15 french-speacking centers) would retrospectively describe a large population.

Official Title
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Veno-arterial Extracorporeal Membrane Oxygenation Support Prior to Left Ventricular Assist Device Implantation : Initial Patients Characteristics and 6 Month Follow-up, a Retrospective Study (2013-2017) (LVAD-ECMO)

Conditions
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Cardiogenic Shock, Heart Failure, Extracorporeal Membrane Oxygenation, Left Ventricular Assist Device

Intervention / Treatment
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* Device: Left Ventricular Assist Device Implantation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Veno-arterial ExtraCorporeal Membrane Oxygenation prior to left ventricular assist device implantation. Veno-arterial ExtraCorporeal Membrane Oxygenation at the left ventricular assist device implantation operative time Exclusion Criteria: ExtraCorporeal Membrane Oxygenation weaving before left ventricular assist device implantation. Cardiac assist devices other than Veno-arterial ExtraCorporeal Membrane Oxygenation

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: Left Ventricular Assist Device Implantation|Veno-arterial extracorporeal membrane oxygenation prior to left ventricular assist device implantation : initial patients characteristics and 6 Month Follow-up|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 6-month hospital discharge after LVAD implantation | 6-month hospital discharge after LVAD implantation | 6 month after LVAD implantation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality rate | Six month mortality rate after LVAD implantation | up to six month after LVAD implantation | 
| ICU discharge | Days until ICU discharge after LVAD implantation | up to six month after LVAD implantation | 
| Quality of life | ADL and IADL scale | up to six month after LVAD implantation | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Left Ventricular Assist Device, Extracorporeal Membrane Oxygenation, Refractory Cardiogenic Shock, Heart Failure, Cardiovascular diseases, Myocardial Infarction, Myocardial Ischemia, Shock