Metabolism Characteristics in the Children With Narcolepsy

Study Overview
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Brief Summary
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A significant weight gain and obesity are observed for most patients with narcolepsy, mainly at the beginning of the disease and narcolepsy in young children. There is no specific study on the population and the consequences of overweight in the lives of these long-term patients. Narcoleptic patients gain weight significantly at the onset of their illness. It is also known that weight gain is not related to the treatment of narcolepsy. The etiology of obesity in narcoleptic patients is not established. Several assumptions were made (physical activity, leptin diet, metabolism). The reason and the pathophysiology of overweight and obesity in this population therefore remain unclear. In this study, potential change in the total metabolism (24h) for narcoleptic children that could explain their tendency to obesity will be assessed ?

Official Title
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Is There a Change in the Total Metabolism Over 24 Hours for Narcoleptic Children That Could Explain Their Tendency to Obesity?

Conditions
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Narcolepsy

Intervention / Treatment
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* Other: Sleep and metabolism assessment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: NARCOLEPTIC PATIENTS Girl or boy age> 6 years <18 years; Narcoleptic: defined by the ICSD diagnostic criteria 2 (International Classification of Sleep Disorders) Beginning of the troubles there more than 6 months Parental consent and agreement of the child. HYPERSOMNIC PATIENTS Girl or boy age> 6 years <18 years; Hypersomnic : defined by the ICSD diagnostic criteria 2 (International Classification of Sleep Disorders) Beginning of the troubles there more than 6 months Parental consent and agreement of the child. Exclusion Criteria: NARCOLEPTIC PATIENTS Secondary Narcolepsy; Narcolepsy already treated with psychostimulant or anticataplectic; Restless legs; Sleep apnea syndrome; Obesity known outside narcolepsy cause; Absence of parental consent. HYPERSOMNIC PATIENTS symptomatic or secondary hypersomnia; Hypersomnia already treated psychostimulant or anticataplectic; Restless legs; Sleep apnea syndrome; Pathology neurological, psychiatric, endocrine or concurrent; Lack of parental consent

Ages Eligible for Study
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Minimum Age: 6 Years
Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Narcoleptic patients<br> | Other: Sleep and metabolism assessment<br> <br> |
| Other: hypersomnic patients<br> | Other: Sleep and metabolism assessment<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Determination of the metabolism at home | Total energy expenditure in kilocalories per minute, including basal metabolic rate (MET) metabolism related to the activity (EEA), and physical activity (PA) measured by accelerometer (Actical) evaluated at home (15 days including scholar and non-scholar days). | 15 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Determination of the metabolism at hospital | Total energy expenditure in kilocalories per minute, including basal metabolic rate (MET) metabolism related to the activity (EEA), and physical activity (PA) measured by accelerometer (Actical) evaluated at hospital over 24 hours. | 18 days | 
| Basal energy expenditure | The basal metabolism (MET) measured by accelerometer (Actical, BodyMedia SW Actiheart) will be compared to the values of energy expenditure (kcal) measured by indirect calorimetry fasting. | 18 days | 
| Energy expenditure and diet-induced thermogenesis | Energy expenditure (kcal) measured by indirect calorimetry after lunch (with counting calories ingested). | 18 days | 
| Sympathetic activity | Estimated from IBI (Interbeat Interval) measured by Actiheart. | 18 days | 
| Food intake | Caloric intake evaluation (kcal per day) during hospitalization (food intake recording) and at home during three days ( two days during the week and one day during the week-end) evaluated by questionnary. | 18 days | 
| Fasting peptide YY |  | 18 days | 
| Body weight | bodyweight (kg) | 18 days | 
| Body height | Body height (cm) | 18 days | 
| Waist and hips circumference | Waist and hips circumference (cm) | 18 days | 
| Measurement of neck | Measurement of neck (cm) | 18 days | 
| Anthropometric measurements | Measurement of BMI Z-score | 18 days | 
| Appetite | appetite evaluation by visual analog scale before each meal | 18 days | 
| Hunger | hunger evaluation by visual analog scale before each meal | 18 days | 
| Fasting IL6-8 levels |  | 18 days | 
| Fasting adiponectin |  | 18 days | 
| Fasting resistin |  | 18 days | 
| Fasting MCP1 |  | 18 days | 
| Fasting PostPrandial |  | 18 days | 
| Fasting GLP1 (glucagon-like peptide-1) |  | 18 days | 
| Fasting Hba1C |  | 18 days | 
| Body mass index z score |  | 18 days | 
| sleep duration |  | 18 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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narcolepsy, metabolism