Investigation of Gait Parameters in Health and Neurological Disease Under Varying Locomotor Conditions

Study Overview
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Brief Summary
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In the cross-sectional component of this study, our overall objective is to gather a large pool of data from which we can generate gait profiles. These profiles will consist of a constellation of gait (+/- electrophysiological) parameters associated with a particular neurological diagnosis or specific lesion(s) in neuroanatomical systems. Once developed, these profiles can be compared for differences and similarities; allowing insights into the specificity of the effect on gait of a given diagnosis or lesion in the case of the former and redundancy of neuroanatomical systems in that of the latter. A longitudinal component of the study will look at the evolution of gait parameters over time in a group of patients with spinal cord injury.

Conditions
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Gait Analysis in Neurological Disorders

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients: age 18 - 80 written, informed consent one of the following established diagnoses: unilateral stroke affecting motor system, Parkinson syndrome, cerebellar disease, vestibular dysfunction, spinal cord injury, multiple sclerosis Brain and whole spine T1, T2 & FLAIR magnetic resonance imaging performed within the last four months and available for study purposes or no contraindications to performing these scans Healthy subjects: age 18 - 80 written informed consent Exclusion Criteria: Patients: Colour-blindness Known to be pregnant or breastfeeding Body mass index (weight in kg/height in metres squared) >40 Unable to walk 50m within 6 minutes (with or without walking aids) Inability to undertake any component of the trial protocol Terminal diagnosis with life expectancy less than six months Cognitive disturbance defined as MMSE < 25 Clinically significant comorbidities such as severe cardiovascular, pulmonary or malignant disease Healthy subjects: Colour-blindness Known to be pregnant or breastfeeding Body mass index (weight in kg/height in metres squared) >40 Unable to walk 50m within 6 minutes Reliance on walking aids / prostheses for mobilisation Significant neurological or orthopaedic diagnosis with potential impact on gait // Previous operations on the lower limbs or spine with potential impact on gait Inability to undertake any component of the trial protocol Clinically significant conditions such as severe cardiovascular, pulmonary or malignant disease

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| patients<br> | |
| healthy control subjects<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of gait parameter after injury to CNS |  | Timepoint 0 plus timepoint 6 months and 12 months |