linjc16/ctgov huggingface dataset:
A Comparison Study of the Tensile Strength of Sutures Used in Dermatologic Surgery on the Day of Suture Removal, Following Wound Care With Two Different Products

Study Overview
=================
Brief Summary
-----------------
Sutures are an integral part of surgery and available materials are diverse, as are the options for post-procedure care. Both saline and hydrogen peroxide are commonly used cleansing agents. This study aims to compare the effect of saline and hydrogen peroxide on the tensile strength of 4-0 nylon sutures following removal from a cutaneous surgical wound.

Official Title
-----------------
A Comparison Study of the Tensile Strength of Sutures Used in Dermatologic Surgery on the Day of Suture Removal, Following Wound Care With Two Different

Conditions
-----------------
Sutured Wounds

Intervention / Treatment
-----------------
* Other: Hydrogen peroxide
* Other: Saline


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Subject is willing to comply with the informed consent procedures Subject's wound is on the body or scalp Subject will be able to come to the clinic for suture removal on day 14 Exclusion Criteria: Subject is less than 18 years of age Subject's wound was not closed with 4-0 nylon sutures Subject's wound is on the face Subject plans to apply other topicals to the area under study Subject's suture is removed before or after day 14

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Hydrogen peroxide<br> | Other: Hydrogen peroxide<br>* Once daily topical application of 3% hydrogen peroxide using a cotton-tipped applicator<br>|
| Active Comparator: Saline<br> | Other: Saline<br>* Once daily topical application of normal saline, using a cotton-tipped applicator<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Tensile strength of 4-0 nylon sutures | The tensile strength was defined as the force required to break the suture, with breaking strength as the maximum strength that a material can withstand when subjected to an applied load, without taking into consideration the cross sectional area. The strength of the sutures was measured using a tensometer. | 14 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
suture, tensile strength, wound care, saline, hydrogen peroxide, skin closure, wounds, wound healing, wound cleansing, antiseptics
Families Affected by Dementia: A Survey of Caregivers

Study Overview
=================
Brief Summary
-----------------
The purpose of our study is to better understand how caregivers of individuals with dementia cope with their family member's illness. If you are eligible for the study and would like to participate, we will schedule a one-time phone interview, which will last approximately 2 hours for which you will be compensated for your time.

Detailed Description
-----------------
Eventually, results of this study will be used to develop treatments that will hopefully help caregivers cope more effectively with managing dementia in a loved one.

Official Title
-----------------
Religion and Free Will Perceptions as Coping Mechanisms in Caregivers of Individuals With Dementia

Conditions
-----------------
Dementia

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Caregiver of individual with dementia Relative who is 60 years or older with dementia Live-in, unpaid caregiver Have a working telephone number

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Depression | Measured continuously using the Depression, Anxiety and Stress Scale on a scale of 1 - 56. | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Anxiety | Measured continuously on the Depression, Anxiety, and Stress Scale on a scale of 1 - 56. | 3 months |
The Specific Lung Elastance in Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) Patients in Supine and Prone Position

Study Overview
=================
Brief Summary
-----------------
The investigators aim is to study the specific lung elastance in ALI/ARDS patients during invasive mechanical ventilation, in supine and prone position.

Detailed Description
-----------------
In sedated and paralyzed ALI/ARDS patients, we study and compare the specific lung elastance in supine and prone position during invasive mechanical ventilation.

Official Title
-----------------
The Specific Lung Elastance in ALI/ARDS Patients in Supine and Prone Position

Conditions
-----------------
Acute Lung Injury, Acute Respiratory Distress Syndrome

Intervention / Treatment
-----------------
* Procedure: specific elastance


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: ALI/ARDS patients during invasive mechanical ventilation Exclusion Criteria: Haemodynamic failure, pneumothorax

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br> | Procedure: specific elastance<br>* The investigators study the specific lung elastance in ALI/ARDS patients in supine and prone position.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Specific elastance |  | 5 minutes | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Gas exchange, Respiratory mechanics, Ventilator Induced Lung Injury
Clinical Study Evaluating Outcomes of Reverse Shoulder Arthroplasty With SMR Stemless

Study Overview
=================
Brief Summary
-----------------
The objectives of this study are the assessment of the clinical, radiographical and patient-reported outcomes of SMR Stemless Reverse Shoulder Arthroplasty (LimaCorporate S.p.A.) used as standard of care over a period of at least 2 years of follow-up and the evaluation of the incidence of any complication.

Detailed Description
-----------------
The focus of this study is the evaluation on clinical, patient-reported and radiographical outcomes of SMR Stemless Reverse Shoulder Arthroplasty. There is a retrospective and prospective study population. The follow up time-points are (as of standard of care and not different for this study): Baseline 6 weeks postop 6 months postop 12 months postop 24 months postop

Official Title
-----------------
A Monocentric Clinical Study Evaluating Clinical and Patient-reported Outcomes of Reverse Shoulder Arthroplasty With SMR Stemless

Conditions
-----------------
Rotator Cuff Tear Arthropathy, Osteo Arthritis Shoulders

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: rotator-cuff arthropathy, osteoarthritis approving written informed consent Exclusion Criteria: Female patients who are pregnant, nursing, or planning a pregnancy. All adult patients with any of the SMR Stemless contraindication for use for the reverse configuration as reported in the current local Instruction for use. not consenting in participating in this study

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Subjective Shoulder Value score | Evaluation of the change of the Subjective Shoulder Value score from pre-operative to the last follow-up visit. | 5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| ASES Shoulder Score | Evaluation of the change of the ASES shoulder score from pre-operative to the last follow-up visit. | 5 years | 
| Quick-Dash score | Evaluation of the change of the Quick-Dash score from pre-operative to the last follow-up visit. | 5 years | 
| VAS pain | Evaluation of the change of the VAS pain score from pre-operative to the last follow-up visit. | 5 years | 
| UCLA shoulder score | Evaluation of the change of the UCLA shoulder score from pre-operative to the last follow-up visit. | 5 years | 
| Loosening, implant stability, radiolucent lines | Radiographic evaluation of the implant stability as rate and progression of symptomatic radiolucent lines and loosening. | 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
stemless reverse shoulder arthroplasty
Effect of Calanus Oli on Intra-abdominal Fat, Glucose Tolerance and Lipids in Man

Study Overview
=================
Brief Summary
-----------------
Preliminary studies in rats and mice indicate that calanus oil reduce accumulation of intra-abdominal fat. Pilot studies in humans have shown no adverse effects. In the present study 120 subjects, males and females, 20-65 years old, BMI 25-30 kg/m2 will be included and given calanus oli 1 g twice daily versus placebo for 1 year. The hypothesis is that calanus oil will reduce intra-abdominal fat, improve glucose tolerance and lipid profile.

Official Title
-----------------
Effect of Calanus Oli on Intra-abdominal Fat, Glucose Tolerance and Lipids in Man

Conditions
-----------------
Overweight

Intervention / Treatment
-----------------
* Dietary Supplement: calanus oil
* Dietary Supplement: olive oil


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Body Mass Index (BMI) 25-30 kg/m2 age 20-65 years Exclusion Criteria: diabetes coronary heart disease last 12 months unstable angina pectoris cancer diagnosed the last 5 years use of lipid lowering drugs seafood allergy

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: calanus oil<br>calanus oil 1 gram twice daily | Dietary Supplement: calanus oil<br>* 1 gram twice daily<br>|
| Placebo Comparator: olive oil<br>olive oil 1 gram twice daily | Dietary Supplement: olive oil<br>* 1 gram twice daily<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Intra-abdominal fat as measured with CT scan |  | at the end of 12 months intervention | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| oral glucose tolerance test |  | at the end of 12 months intervention | 
| lipid status |  | at the end of 12 months intervention | 
| systolic and diastolic blood pressure |  | at the end of 12 months intervention | 
| markers of inflammation - C-reactive protein (CRP) |  | at the end of 12 months intervention | 
| body weight |  | at the end of 12 months intervention |
Epithelial Damage in GERD

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to characterize and compare epithelial damage in patients with erosive esophagitis and non-erosive reflux disease.

Official Title
-----------------
Characterisation of Esophageal Epithelial Damage in Patients With Non-erosive Reflux Disease (NERD) and Erosive Esophagitis (EE): Role of Epithelial Permeability

Conditions
-----------------
Gastro-esophageal Reflux Disease

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Typical GERD-symptoms lasting for more than 6 months (recurrent episodes of heartburn or acid regurgitation) abnormal pH-parameters (pathological acid exposure and/or symptom association) Exclusion Criteria: Age <18 years Previous esophageal or gastric surgery Severe esophageal motility disorder on manometry Histological evidence of Barrett's mucosa Severe co-morbidities (including cardiopulmonary disease, portal hypertension, collagen diseases, morbid obesity, coagulation disorders and co-morbidity hindering a gastroscopic procedure) Use of anticoagulant or immunosuppressive drugs Inability to stop medication that can influence the test results, like PPI, for at least 10 days before tests Excessive alcohol consumption (>20 units per week) Patients unable to give informed consent.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Erosive Esophagitis<br> | |
| Non-erosive Reflux Disease<br> | |
| Heatlhy volunteers<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Epithelial integrity in tissue biopsies |  | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Immunohistochemical markers in tissue biopsies |  | 1 year | 
| Histological changes in tissue biopsies |  | 1 year |
Distinction of Cone Outer Segment Tips by Spectral-Domain Optical Coherence Tomography in Normal Eyes

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to investigate the incidence and possible causes of obscured or disrupted cone outer segment tips line at fovea in spectral-domain optical coherence tomography images of normal eyes.

Detailed Description
-----------------
Thirty-seven eyes of 37 individuals without eye diseases were included in this study. Optical Coherence Tomography (OCT) images were taken using Cirrus HD-OCT (Carl Zeiss Meditec) with 5 line raster and high-definition 5 line raster modes. Images with signal strength weaker than 5/10 were excluded. Distinction of COST line and the integrity of COST line, external limiting membrane, and the photoreceptor inner segment and outer segment junction at the fovea were recorded. Demographic data, refractive error of the eyes, signal strengths of the OCT images were acquired for analysis.

Official Title
-----------------
Distinction of Cone Outer Segment Tips by Spectral-Domain Optical Coherence Tomography in Normal Eyes

Conditions
-----------------
Healthy

Intervention / Treatment
-----------------
* Other: Optical coherence tomography


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: individuals without eye diseases Exclusion Criteria: individuals with eye diseases

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Normal subjects<br>Thirty-seven eyes of 37 individuals without eye diseases | Other: Optical coherence tomography<br>* Optical coherence tomography<br>* Other names: Cirrus HD-OCT (Carl Zeiss Meditec);|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Microstructural analysis by Spectral domain optical coherence tomography | SD-OCT images of 6 mm scans were taken using Cirrus HD-OCT (OCT 4000, Carl Zeiss Meditec, Dublin, CA) with 5 line raster (5LR) and high-definition 5 line raster (HD5LR) modes. | one year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Visual acuity | Each subject had a routine eye examination including measuring best-corrected visual acuity (BCVA) and intraocular pressure. | one year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
cone outer segment tips line, Optical coherence tomography
Evidence-based Screening Strategies for Celiac Disease

Study Overview
=================
Brief Summary
-----------------
Main aim: To find evidence-based screening strategies for celiac disease in high risk groups and to find new biomarkers or biomarker combinations for celiac disease diagnostics and follow-up.

Detailed Description
-----------------
The current project will result in the identification of genetic, environmental or downstream biomedical markers that predict the development of celiac disease at the individual level. Moreover, the markers can be exploited in prediction of specific disease risks, manifestations, comorbidities and complications.

Official Title
-----------------
Improving Case-finding Strategies for Celiac Disease in Family Members: a Follow-up Study

Conditions
-----------------
Celiac Disease

Intervention / Treatment
-----------------
* Diagnostic Test: Celiac disease antibody screening


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Cohort 1: Family member of celiac disease patient Cohort 2: Previously diagnosed celiac disease Exclusion Criteria: Cohort 1: No previous celiac disease Cohort 2: Celiac disease diagnosis not confirmed

Ages Eligible for Study
-----------------
Minimum Age: 6 Months
Maximum Age: 100 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Healthy family members of celiac disease<br>Celiac disease screening, no intervention. | Diagnostic Test: Celiac disease antibody screening<br>* Observational parameters<br>|
| Celiac disease index cases<br>Assessment of disease related factors, no intervention. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Forthcoming celiac disease diagnosed by current diagnostic criteria | Assessed by positive transglutaminase antibodies, small bowel mucosal villous atrophy | With in 10 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Celiac disease, Gluten, Microbiome, Genetic
Impact of P53 and SIRT1 in Type 2 Diabetes

Study Overview
=================
Brief Summary
-----------------
Investigating the impact of p53 and SIRT1 in the development of type 2 DM

Detailed Description
-----------------
Investigating the impact of p53 and SIRT1 in the development of type 2 DM through the treatment of prediabetic individuals by either nigetella salivata or Metformin

Official Title
-----------------
Investigating the Impact of p53 and SIRT1 in the Development of Type 2 DM Through the Treatment of Prediabetic Individuals by Either Nigetella Salivata or Metformin

Conditions
-----------------
DM

Intervention / Treatment
-----------------
* Other: life style
* Drug: Metformin
* Drug: Nigetella salivata


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Prediabetic subjects. Exclusion Criteria: Confirmed diabetes. Hepatic or renal impairment.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: life style<br>life style control only | Other: life style<br>* life sryle control only<br>* Other names: life style management;|
| Active Comparator: Metformin<br>Metformin 500 mg twice daily | Drug: Metformin<br>* metformin twice daily<br>* Other names: cidophage;|
| Experimental: Nigetella salivata<br>NS 450 mg twice daily | Drug: Nigetella salivata<br>* NS twice daily<br>* Other names: NS;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patients with improved insulin resistance | Number of patients showing improved insulin resistance | 6 months |