Temporal Relationship in Recovery of Muscular Pain and Functional Variables in an Experimental Muscular Pain Model in Hamstrings

Study Overview
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Brief Summary
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Basal measurements are taken in relation to the study variables. Immediately subjects perform eccentric exercise on right hamstrings to develop delayed onset muscle soreness (DOMS). Measurements of the study variables are taken in the same conditions 48, 96 and 168 hours after the exercise to study the evolution of the variables while recovering from DOMS.

Detailed Description
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Basal measurements are taken in relation to the study variables. The variables are: pressure pain thresholds electromyography values static and dynamic plantar pressure measurement active knee extensibility maximal strength of knee flexors thermography scales of pain perception Immediately subjects perform eccentric exercise on right hamstrings to develop DOMS (delay onset muscle soreness). Measurements of the study variables are taken in the same conditions 48, 96 and 168 hours after the exercise to study the evolution of the variables while recovering from DOMS.

Official Title
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Temporal Relationship in Recovery of Muscular Pain, Functional Variables and Normal Gait Pattern in an Experimental Muscular Pain Model in Hamstrings

Conditions
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Pain, Muscle

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: not sedentary subject (IPAQ scale > 600 MET) healthy subjects, without pain nor injury at the moment Exclusion Criteria: subjects with acute or chronic pain on every spot of pelvis or lower limbs at the momento or for the last 3 months; subjects with history of severe injury in the hamstrings muscles; presence of serious illness; presence of pathologies in relation to chronic pain (as fibromyalgia, migraine disorders, non specific and chronic lumbar pain); not commitment for continuity in the study program;

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in spatio temporal parameters of gait | Changes in spatio temporal parameters of gait over a treadmill will be measurement using an optical measurement system consisting of a transmitting and receiving bar (OptoGait System). | Baseline, 48 hours, 96 hours, 1 week | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in Pressure Pain Thresholds | Changes in pressure pain thresholds (PPT) will be determined with pressure algometry bilaterally over the leg and shoulder. PPT is defined as the exact time point where the pressure is first being perceived at painful. | Baseline, 48 hours, 96 hours, 1 week | 
| Changes in active knee extension test | Changes in range of motion (°; degrees) will be assessed in both sides using the active knee extension (AKE) test. AKE test: subject is lying prone with hip and knee flexed at 90°. Then, maximal knee extension is performed. | Baseline, 48 hours, 96 hours, 1 week | 
| Changes in knee-flexors maximal isometric muscle strength | Changes in knee-flexors maximal isometric strength (Newton) will be assessed by using a hand-held dynamometer. | Baseline, 48 hours, 96 hours, 1 week | 
| Electromyography (EMG) measurement during the tests | Electromyography values will be taken from hamstrings during the performance of gait analysis and dynamometry | Baseline, 48 hours, 96 hours, 1 week | 
| Changes in thermography on hamstrings areas | A thermography image will be taken every day of assessment. Changes in colour pixels will be analysed to determine temperature changes. | Baseline, 48 hours, 96 hours, 1 week | 
| Changes in static and dynamic plantar pressure measurement | Changes in static and dynamic plantar pressure measurement will be performed in every session by using a pressure platform. | Baseline, 48 hours, 96 hours, 1 week | 
| Changes in subjective perception of pain and impairment: Two questionnaire (Modified 7-item Likert Scales) | Two questionnaires (Modified 7-item Likert Scales) are filled up by the subject to show subjective perception of pain related to movement along the recovery period. Scale of pain intensity, from 0 (no pain) to 6 (higher pain intensity). Scale of functional impairment, from 0 (no impairment) to 6 (higher impairment). | 48 hours, 96 hours, 1 week | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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DOMS, Healthy subjects, Pressure pain thresholds, Active Knee Extension test, Maximal strength, Electromyography, Plantar pressure measurement, Gait analysis