Relationships Between Vitamin D and Orthopedic Trauma

Study Overview
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Brief Summary
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Vitamin D is an essential hormone involved in bone metabolism, bone mineral density maintenance, and bone health. Vitamin D deficiency is putatively linked to poor pediatric orthopedic outcomes [1]. Further, the risk of low vitamin D associated fractures may be greater in minority pediatric populations [2]. In adults, utility of vitamin D alleles as a biomarker for bone density and fracture risk has been debated for over 10 years [3-5]. Peak bone density is achieved at 25 years old; however, most orthopedic trauma patients less than 25 years of age present with substantial vitamin D deficiencies.

Detailed Description
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INTRODUCTION 1.1. Background Vitamin D is an essential hormone involved in bone metabolism, bone mineral density maintenance, and bone health. Vitamin D deficiency is putatively linked to poor pediatric orthopedic outcomes [1]. Further, the risk of low vitamin D associated fractures may be greater in minority pediatric populations [2]. In adults, utility of vitamin D alleles as a biomarker for bone density and fracture risk has been debated for over 10 years [3-5]. Peak bone density is achieved at 25 years old; however, most orthopedic trauma patients less than 25 years of age present with substantial vitamin D deficiencies. 1.2. Aim(s) Identify the prevalence of vitamin D deficiency in young trauma patients with fractures. Describe the merits of vitamin D supplementation in healing and long-term outcomes ≤25 year old trauma patients with fractures. 1.3. Rationale for the study Occurrence of stress and low energy mechanism fractures within a population at peak bone density is troubling and suggestive of underlying pathology. Understanding how to combat vitamin D deficiency, and improve outcomes, is essential in the development of comprehensive and preventative trauma care. 1.4. Hypothesis 1.4.1. Primary Hypothesis Patients aged ≤25yrs old with fractures will have low vitamin-D levels. OBJECTIVES AND STUDY OUTCOME MEASURES 2.1. Study Objectives 2.1.1. Primary Objective Determine the frequency of vitamin D deficiency in fracture patients aged less than 25 years old. 2.1.2. Secondary Objective Report the long-term (one year) outcomes for fracture healing relative to baseline and therapeutic vitamin D levels. 2.2. Study Outcome Measures 2.2.1. Primary Outcome Vitamin D levels at the time of the index injury through one year post-operative follow up. 2.2.2. Secondary Outcomes Patient demographics (age, sex, ethnicity), injury characteristics, lab values, rate of nonunion (i.e., failure of a fractured bone to heal), admit information, discharge disposition, payer type, and mortality. STUDY DESIGN All patients between 18 and 25 years treated for fractures at Methodist Dallas Medical Center (MDMC) with an index admission vitamin D assessment will be enrolled. This study will consider any patients with an index admission occurring between February 2016 and February 2020. No changes to care or intervention will occur and this study will be conducted completely via chart review. The aim is to identify 100 subjects with a one-year follow-up appointment for their injury to determine the rate of nonunion and vitamin D levels. As patients receive vitamin D supplementation as standard of care if index values are low, impact will be assessed through relative deficiency and clinical outcomes. Data collected from subjects without need for supplementation may be used to generate a threshold. Patient demographics will be considered as practice suggests minority patients may be disproportionally affected. The plan to complete the data collection and analysis by February 2021.

Official Title
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Relationships Between Vitamin D and Orthopedic Trauma

Conditions
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Fracture, Fracture Nonunion, Fractures, Bone, Vitamin D

Intervention / Treatment
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* Other: Vitamin D Assessment
* Other: Fracture


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients must be >18 years old and ≤25 years old Patients must have any fracture requiring follow-up Patients must have received vitamin-D assessment Exclusion Criteria: Patients aged >25yrs Prisoners Pregnant

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 25 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Fracture and Vitamin D assessment<br>All patients between 18 and 25 years treated for fractures at Methodist Dallas Medical Center (MDMC) with an index admission vitamin D assessment will be enrolled. This study will consider any patients with an index admission occurring between February 2016 and February 2020. No changes to care or intervention will occur and this study will be conducted completely via chart review. The aim is to identify 100 subjects with a one-year follow-up appointment for their injury to determine the rate of nonunion and vitamin D levels. As patients receive vitamin D supplementation as standard of care if index values are low, impact will be assessed through relative deficiency and clinical outcomes. Data collected from subjects without need for supplementation may be used to generate a threshold. | Other: Vitamin D Assessment<br>* index admission vitamin D assessment<br>Other: Fracture<br>* rate of nonunion (i.e., failure of a fractured bone to heal)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Vitamin D levels at the time of the index injury through one year post-operative follow up. | Vitamin D levels at the time of the index injury through one year post-operative follow up. | February 2016 and February 2020 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patient demographics | age, sex, ethnicity | February 2016 and February 2020 | 
| injury characteristics | injury characteristics | February 2016 and February 2020 | 
| rate of nonunion | failure of a fractured bone to heal | February 2016 and February 2020 | 
| admit information | admit information | February 2016 and February 2020 | 
| discharge disposition | discharge disposition | February 2016 and February 2020 | 
| payer type | payer type | February 2016 and February 2020 | 
| mortality | mortality | February 2016 and February 2020 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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fracture nonunion, vitamin D, fracture