Iron Deficiency Anemia Among Chinese Pregnant Women: a Multi-center Prospective Cohort Study

Study Overview
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Brief Summary
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Iron deficiency anemia during pregnancy, which may lead to adverse pregnancy outcomes, was a serious health problem in China. Various iron supplements used in different regions of China, however, the effects have not been well investigated. The objective of this study is to investigate the diagnosis, treatment and prognosis of iron deficiency and iron deficiency anemia in Chinese pregnant women.

Detailed Description
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This is a nationwide multicenter prospective cohort study conducted in seven hospitals in China to investigate the diagnosis, treatment and prognosis of iron deficiency and iron deficiency anemia in Chinese pregnant women. This study will enroll about 6000-7000 pregnant women, who established a health record in the seven hospitals. Demographic characteristics, laboratory tests, behavior habits during pregnancy, mental status, and pregnancy outcomes will been collected. All information will collect by a pregnant women self-reported questionnaire and the electronic medical record system in hospitals at three timing points: 6-15 gestational weeks, 30-34 gestational weeks and one week after delivery.

Official Title
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Iron Deficiency Anemia Among Chinese Pregnant Women (IRON WOMEN): a Multi-center Prospective Cohort Study

Conditions
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Iron Deficiency Anemia of Pregnancy

Intervention / Treatment
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* Other: Iron deficiency anemia in Chinese pregnant women


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Pregnant women who registered an antenatal care file at the survey hospital ; Signed informed consent. Exclusion Criteria: Participated in any drug or nutritional clinical trial from 3 months before pregnancy to recruitment.
Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Exposure group<br>Chinese women with iron deficiency anemia (IDA) during pregnancy. | Other: Iron deficiency anemia in Chinese pregnant women<br>* Iron deficiency anemia exists in Chinese pregnant women during pregnancy<br>|
| Control group<br>Chinese women without iron deficiency anemia (IDA) during pregnancy. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| adverse maternal outcomes | Including iron deficiency anemia rate, pregnancy hypertension syndrome rate, gestational diabetes mellitus rate, cesarean section rate, and other adverse maternal outcomes rate. The definition of adverse maternal outcome was according to International Glossary on Infertility and Fertility Care (2017), and the rate of adverse maternal outcome was calculated by the number of adverse maternal outcome divided by the total number of pregnant women. | 40 weeks | 
| adverse neonatal outcomes | Including miscarriage rate, premature birth rate, birth defect rate, low birth weight rate, and other adverse neonatal outcomes. The definitions of adverse neonatal outcomes were according to International Glossary on Infertility and Fertility Care (2017), and the rate of adverse neonatal outcomes were calculated by the number of advers neonatal outcomes divided by the total number of pregnancy or birth. | 40 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Iron Deficiency Anemia, iron supplements, Chinese pregnant women, adverse maternal outcomes, adverse neonatal outcome