The Effect of Vinegar on Glucose and Lipid Metabolism in Subjects With Impaired Glucose Tolerance or Type 2 Diabetes

Study Overview
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Brief Summary
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This open, randomized, cross-over, placebo-controlled study aims to investigate the effects of vinegar on glucose metabolism, endothelial function and circulating lipid levels in subjects with impaired glucose tolerance or type 2 diabetes, using the arteriovenous difference technique.

Detailed Description
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Subjects with IGT or type 2 diabetes will be randomised to consume 20ml vinegar (6% acetic acid) or placebo before a mixed meal. Plasma samples will be taken for 300min from the radial artery and from a forearm vein for measurements of glucose, insulin, triglycerides, non-esterified fatty acids (NEFA) and glycerol. Muscle blood flow will be measured with strain-gauge plethysmography. Glucose flux will be calculated as the arteriovenous difference of glucose multiplied by the blood flow rates.

Official Title
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The Effect of Vinegar on Glucose and Lipid Metabolism in Peripheral Tissues in Subjects With Impaired Glucose Tolerance or Type 2 Diabetes

Conditions
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Type 2 Diabetes

Intervention / Treatment
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* Dietary Supplement: Vinegar
* Other: Placebo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Subjects with impaired glucose tolerance or newly diagnosed type 2 diabetes before the initiation of medication therapy Recreationally active With stable body weight and diet during the last two months. Exclusion Criteria: Any systemic disease (besides glucose abnormalities) Any medication therapy Diabetic complications

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Vinegar<br>0,50mmol vinegar (6% acetic acid) | Dietary Supplement: Vinegar<br>* 0,50mmol vinegar (6% acetic acid)<br>|
| Placebo Comparator: Placebo<br>50 ml water | Other: Placebo<br>* 50 ml water<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Muscle glucose uptake following meal ingestion (area under the glucose uptake versus time curve-AUC) |  | 0, 30, 60, 90, 120, 180, 240, 300 min postmeal | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Plasma glucose levels following meal ingestion (area under the plasma concentration versus time curve-AUC) |  | 0, 30, 60, 90, 120, 180, 240, 300 min postmeal | 
| Plasma insulin levels following meal ingestion (area under the plasma concentration versus time curve-AUC) |  | 0, 30, 60, 90, 120, 180, 240, 300 min postmeal | 
| Plasma triglyceride levels following meal ingestion (area under the plasma concentration versus time curve-AUC) |  | 0, 30, 60, 90, 120, 180, 240, 300 min postmeal | 
| Plasma NEFA levels following meal ingestion (area under the plasma concentration versus time curve-AUC) |  | 0, 30, 60, 90, 120, 180, 240, 300 min postmeal | 
| Plasma glycerol levels following meal ingestion (area under the plasma concentration versus time curve-AUC) |  | 0, 30, 60, 90, 120, 180, 240, 300 min postmeal | 
| Muscle blood flow following meal ingestion (area under the blood flow rates versus time curve-AUC) |  | 0, 30, 60, 90, 120, 180, 240, 300 min postmeal | 
| Number of participants with adverse events |  | 300 min postmeal |