Cushing´s Disease Epidemiology in Sweden

Study Overview
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Brief Summary
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The purpose of this study is to study since 1987 all patients diagnosed with CD in Sweden and determine their outcomes including mortality. A secondary objective is to focus on patients in remission and identify determinants of their different outcomes.

Detailed Description
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This study is a retrospective nationwide study of all patients in Sweden with diagnosis CD between 1987 and 2013 were baseline data at diagnosis, information about the different treatments and follow-up data is going to be obtained by reviewing patients' medical journals. This information as well as the exact diagnose criteria for each patient are going to be extracted by Endocrinologists in all University Hospitals in Sweden. An expert group at the Sahlgrenska University Hospital in Gothenburg will put together the data.By the use of the Swedish Personal Number, the investigators are going to obtain information about both patients' and background population co-morbidities which have been collected in the different Swedish Registers. Primary aim: To study mortality of CD in Sweden. Secondary aims: To study the influence of CD on myocardial infarction To study the influence of CD on stroke To study the influence of CD on cancer To study the influence of CD on hip fracture risk To study incidence and prevalence of CD in Sweden.

Official Title
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National Swedish Study in Cushing´s Disease Incidence and Outcomes

Conditions
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Cushing Disease

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All patients registered with Cushing's Disease in Sweden since 1987 in the statistical database for in- and out-patients, at the Swedish National Board of Health and Welfare will be included in the study. Exclusion Criteria: No

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with verified Cushing's Disease<br>Patients with verified Cushing's Disease | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality | If event (death) has been occured during the observation period. Data obtained by the Swedish Cause Of Death Register (Swedish Board of Health and Welfare) | From date of diagnosis until the last day of December 2014 or date of death from any cause, whichever came first, assessed up to 20 years. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| influence of Cushing's Disease on myocardial infarction | If event (myocardial infarction) has been occured during the observation period.Data obtained by the Swedish Register of In- and Out-patient Diagnoses (Swedish Board of Health and Welfare) | From date of diagnosis until the last day of December 2014 or date of death from any cause, whichever came first, assessed up to 20 years | 
| influence of Cushing's Disease on stroke | If event (stroke) has been occured during the observation period.Data obtained by the Swedish Register of In- and Out-patient Diagnoses (Swedish Board of Health and Welfare) | From date of diagnosis until the last day of December 2014 or date of death from any cause, whichever came first, assessed up to 20 years | 
| influence of Cushing's Disease on cancer | If event (cancer) has been occured during the observation period.Data obtained by the Swedish Register of Cancer Diagnoses (Swedish Board of Health and Welfare) | From date of diagnosis until the last day of December 2014 or date of death from any cause, whichever came first, assessed up to 20 years | 
| influence of Cushing's Disease on hip fracture risk | If event (hip fracture) has been occured during the observation period.Data obtained by the Swedish Register of Hip Fractures (Swedish Board of Health and Welfare) | From date of diagnosis until the last day of December 2014 or date of death from any cause, whichever came first, assessed up to 20 years | 
| incidence of Cushing's Disease in Sweden | Validation of Data obtained by The Swedish Board of Health and Welfare by reviewing all patients' journals | Assessed up to 20 years. | 
| prevalence of Cushing's Disease in Sweden | Validation of Data obtained by The Swedish Board of Health and Welfare by reviewing all patients' journals | Assessed up to 20 years. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Mortality, Morbidity, Incidence, Prevalence