Sublingual Microcirculation Data of Patients With Systemic Diseases

Study Overview
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Brief Summary
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This is an observational clinical study, patients with systemic diseases will be enrolled according to the inclusion and exclusion criteria. 360 patients will received the examination of sublingual microcirculation by using sidestream dark filed video microscope. The microcirculation data includes total small vessel density, perfused small vessel density, microvascular flow index, and heterogeneity index. The patients will be divided into right groups according to their systemic diseases as follows: group 1 hypertension (60 patients), group 2 diabetes mellitus (60), group 3 hypertension and diabetes mellitus (60), group 4 end stage renal disease with hemodialysis (60), group 5 peripheral arterial occlusive disease (30), group 6 coronary artery disease (30), group 7 liver cirrhosis (30), and group 8 anemia (30).

Official Title
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Population Research of Sublingual Microcirculation Data of Patients With Systemic Diseases

Conditions
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Sublingual Microcirculation Status

Intervention / Treatment
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* Other: No intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients aged from 20 to 79 years old BMI ranged from 18.5 to 27 kg/m2 Presence of one of the condition Diagnosed hypertenison > 6 months, without other systemic diseases Diagnosed diabetes mellitus > 6 monthes, without other systemic diseases Diagnosed with both hypertension and diabetes mellitus > 6 months, without other systemic diseases Diagnosed with end stage renal disease and recevied renal replacement therapy > 6 months Diagnosed with peripheral arterial occlusive diseases > 6 months Diagnosed with coronary artery disease > 6 months Diagnosed with liver cirrhosis > 6 months Diagnosed with anemia > 6 months, hemoglobin level < 10 g/dL Exclusion Criteria: Diagnosed with sepsis, major tauma, or admission to ICU within one month Body temperature higher than 37.5 ℃ or lower than 35.5 ℃ Any on of the following condition Asthma Chronic obstructive pulmonary disease Endocrine diseases Hematological disorders Uncured cancer Chronic uncured infection Other major disease with limited daily activity Non-native speakers

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 79 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1_Hypertension<br>Patients with diagnosed hypertension, without other systemic diseases | Other: No intervention<br> <br> |
| 2_Diabetes mellitus<br>Patients with diagnosed diabetes mellitus, without other systemic diseases | Other: No intervention<br> <br> |
| 3_Hypertension and diabetes mellitus<br>Patients with both diagnosed hypertension and diabetes mellitus | Other: No intervention<br> <br> |
| 4_end stage renal disease with hemodialysis<br>Patients with end stage renal disease with hemodialysis | Other: No intervention<br> <br> |
| 5_Peripheral arterial occlusive disease<br>Patients with disgnosed peripheral arterial occlusive disease | Other: No intervention<br> <br> |
| 6_Coronary artery disease<br>Patients with diagnosed coronary artery disease | Other: No intervention<br> <br> |
| 7_liver cirrhosis<br>Patients with diagnosed liver cirrhosis | Other: No intervention<br> <br> |
| 8_Anemia<br>Patients with diagnosed anemia | Other: No intervention<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Total small vessel density of sublingual small vessels | Total small vessel density will be measured by Microscan and analyzed by AVA 3.0 software | Once at enrollment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Perfused small vessel density of sublingual small vessels | Perfused small vessel density will be measured by Microscan and analyzed by AVA 3.0 software | Once at enrollment |