Mycoprotein and Muscle Protein Synthetic Response

Study Overview
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Brief Summary
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Dietary protein is vital for the preservation of health and optimal adaptation to training. However, traditional animal proteins come with a number of economic, environmental, and ethical issues. Accordingly, there is a need to develop an understanding of the utility of more sustainable non-animal derived dietary proteins to support our nutrition. Mycoprotein, produced by Quorn Foods™, has recently been shown to stimulate a greater anabolic response within skeletal muscle compared with milk protein, suggesting its utility within sports nutrition. However, it is unclear what accounted for the greater anabolic response of mycoprotein. One explanation could be the non-protein nutrients contained within mycoprotein (e.g. fibre, carbohydrate, fat or micronutrients). Therefore, the present study will compare the muscle anabolic response between mycoprotein (MYC) as a whole food and the protein isolated from mycoprotein (PIM).

Official Title
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Comparing the Muscle Protein Synthetic Response to Ingestion of Mycoprotein vs Protein Isolated From Mycoprotein

Conditions
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Anabolic Response to Mycoprotein and Micronutrient Ingeston

Intervention / Treatment
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* Dietary Supplement: Mycoprotein ingestion


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: BMI between 18 and 30. Resistance trained Exclusion Criteria: Any metabolic impairments. Cardio/pulmonary diseases. Chronic use of over the counter pharmaceuticals A personal or family history of epilepsy, seizures or schizophrenia. Allergic to mycoprotein/Quorn/edible fungi/environmental mould products.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Mycoprotein<br>Mycoprotein in its full food matrix | Dietary Supplement: Mycoprotein ingestion<br>* The ingestion of mycoprotein<br>|
| Experimental: Protein Isolated from Mycoprotein<br>Protein from mycoprotein isolated from the food matrix | Dietary Supplement: Mycoprotein ingestion<br>* The ingestion of mycoprotein<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Muscle protein synthesis | The rate of synthesis of new muscle protein (Fractional Synthetic Rate %/h) | 7.5 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Plasma Amino Acid Kinetics | The rate of appearance of amino acids ingested in the drink | 7.5 hours | 
| Blood Glucose | The levels of glucose in the blood | 7.5 hours | 
| Serum Insulin | The levels of insulin in blood serum | 7.5 hours |