LSFG-SKIN, Laser Speckle Flowgraphy

Study Overview
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Brief Summary
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The purpose of this project is to quantify normal and abnormal skin blood flow regionally in different areas of the body(face, extremities, over burns and wounds) at baseline and over time in response to treatment or environmental changes, such as temperature, light and pressure.

Detailed Description
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Laser speckle skin blood flow (LSFG-SKIN) will be recorded in normal subjects and in patients with disorders affecting skin capillary perfusion, which may include cardiovascular disorders, dermatologic disorders, skin wounds, ocular disorders, psychiatric disorders, and neurologic disorders.

Official Title
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LSFG-SKIN, Laser Speckle Flowgraphy

Conditions
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TIA, Hypertension, Heart Failure, Vascular Ischemia, Burns, Chemotherapy Effect, Radiation Injuries, Uveitis, Scleritis, Multiple Sclerosis, Autonomic Neuropathy, Stroke, Intracranial Hemorrhages, Migraine, Headache, Pain

Intervention / Treatment
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* Device: laser speckle flowgraphy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Controls ●Healthy normal control subjects ages 18-90 Cardiology Subjects Ages 18-90 History of dysrhythmia, heart failure, cardiac ischemia, hypertension, peripheral vascular disease Dermatology Subjects Ages 18-90 History of inflammatory and cancerous lesions Endocrine Subjects Ages 18-90 History of diabetes, thyroid disease Neurology Subjects Ages 18-90 History of dementia, headaches, Parkinson's, light sensitivity, stroke, TIA, multiple sclerosis Psychiatry Subjects Ages 18-90 History of bipolar, schizophrenia, anxiety, depression Surgery Subjects Ages 18-90 History of skin wounds(trauma, chemotherapy, radiation), thermal burns, or plastic and reconstructive surgical procedures. Ophthalmology Subjects Ages 18-90 History of ocular disorders caused by hypo perfusion or inflammatory disorders Exclusion Criteria: Controls Cataract or media opacity that would degrade the imaging of the retina. Mild cataracts are okay. Angle closure glaucoma Cardiology Subjects Cataract or media opacity that would degrade the imaging of the retina. Mild cataracts are okay. Angle closure glaucoma 3. Dermatology Subjects Cataract or media opacity that would degrade the imaging of the retina. Mild cataracts are okay. Angle closure glaucoma Endocrine Subjects Cataract or media opacity that would degrade the imaging of the retina. Mild cataracts are okay. Angle closure glaucoma Neurology Subjects Cataract or media opacity that would degrade the imaging of the retina. Mild cataracts are okay. Angle closure glaucoma Psychiatry Subjects Cataract or media opacity that would degrade the imaging of the retina. Mild cataracts are okay. Angle closure glaucoma Surgery Subjects Cataract or media opacity that would degrade the imaging of the retina. Mild cataracts are okay. Angle closure glaucoma Ophthalmology Subjects Cataract or media opacity that would degrade the imaging of the retina. Mild cataracts are okay. Angle closure glaucoma

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Clinic Subjects<br>cardiology subjects, dermatology subjects, endocrine subjects, neurology subjects, psychiatry subjects, surgery subjects, ophthalmology subjects. | Device: laser speckle flowgraphy<br>* blood flow state of the skin as real time two dimensional image<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Imaging Blood Flow | Imaging blood flow in the tissue is of major importance in the clinical environment | One visit | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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perfusion, inflammatory, ischemia, lesions, neuropathy, burns, cancer, stroke