linjc16/ctgov huggingface dataset:
A Study of Cerebral-circulatory Response to Intravenous Antihypertensive Treatment in Women With Serious Preeclampsia

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is a systematical registration of hemodynamic measurements (cardiac output, blood pressure and systemic vascular resistance) in women with serious preeclampsia.

Official Title
-----------------
A Study of Cerebral-circulatory Response to Intravenous Antihypertensive Treatment in Women With Serious Preeclampsia

Conditions
-----------------
Preeclampsia

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Women with serious preeclampsia

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hemodynamic and cerebral-circulatory variations in preeclamptic women |  | days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Preeclampsia, Trans cranial Doppler, Cardiac output, systemic vascular resistance, blood pressure
Flexion Versus Extension Soft Tissue Repair in Total Knee Arthroplasty

Study Overview
=================
Brief Summary
-----------------
The purpose of the present study is to determine the influence of position of soft tissue repair (flexion versus extension) in post operative range of motion(ROM) and functional outcome in patients who underwent primary total knee arthroplasty (TKA).

Conditions
-----------------
Total Knee Arthroplasty(TKA), Total Knee Replacement

Intervention / Treatment
-----------------
* Procedure: soft tissue repair in flexion position
* Procedure: soft tissue repair in extension position


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: were individuals with osteoarthritis indicated for primary Total Knee Arthroplasty Exclusion Criteria: previous fracture in thigh previous fracture in leg previous high tibial osteotomy
Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: flexion position<br> | Procedure: soft tissue repair in flexion position<br> <br> |
| Experimental: extension position<br> | Procedure: soft tissue repair in extension position<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Knee Range of Motion (ROM) | in all patients ROM is measure 1 year after knee surgery by one of the study investigator using goniometer. | 1 year after total knee arthroplasty |
The Effects of Neuromuscular Exercise Training on Core Stability and Hip Strength in Healthy Adolescent Females

Study Overview
=================
Brief Summary
-----------------
This study is an evaluation of the effects of a Neuromuscular training program on hip strength and core stability. It is a randomized clinical trial evaluating pre and post scores.

Official Title
-----------------
The Effectiveness of Neuromuscular Exercise Training on Core Stability and Hip Strength in Healthy Adolescent Females

Conditions
-----------------
Anterior Cruciate Ligament Injury

Intervention / Treatment
-----------------
* Other: Neuromuscular exercise training


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: healthy adolescent females between 12 and 18 years old Exclusion Criteria: lower body injuries in the last 6 months or lower body injuries that they are currently receiving treatment inability to participate in 5 week NME training program

Ages Eligible for Study
-----------------
Minimum Age: 12 Years
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Training<br>Neuromuscular exercise training group will complete a 5 week NME training program | Other: Neuromuscular exercise training<br> <br> |
| No Intervention: Control<br>Control group will have 5 weeks with no intervention prior to being re-tested | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hip Strength - Hand Held Dynamometry |  | up to 6 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Core Stability - Dynamic Stability Sit test |  | up to 6 weeks |
The Empowerment Model Towards Type 2 Diabetic Adults To Enhance Vegetable Intake in Achieving Glycemic Control

Study Overview
=================
Brief Summary
-----------------
Life style changes, particularly in dietary patterns have contributed a great deal to the incidence and risks of type 2 Diabetes. Decreased intakes of vegetables and fruits replaced by pre processed food, added sugar and those of animal origin lead towards rapid increase of adult-onset-diabetes. In spite of the knowledge of the benefit of consuming vegetable and fruits, and people are well informed, they still need to be committed to perform a behavior and implement these intention. Behavioral approach methods have demonstrated successful adherence in health education with life style changes. Objective: To identify the impact of The Empowerment Model to enhance vegetable intake in Type 2 Diabetes Mellitus adults in achieving glycemic control.

Official Title
-----------------
The Empowerment Model Towards Type 2 Diabetic Adults To Enhance Vegetable Intake in Achieving Glycemic Control

Conditions
-----------------
Glycemic Control for Diabetes Mellitus

Intervention / Treatment
-----------------
* Behavioral: Empowerment model to improve dietary intake
* Other: Control group following conventional approach


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: fasting blood glucose ≥126 mg/dL HbA1C >8% Exclusion Criteria: those who have serious, unstable medical conditions, or related to metabolic disorders (i.e. thyroid diseases) significant co-morbid illnesses such as liver disease, kidney disease, cancer, bowel diseases/ malfunction, pregnancy or nursing mothers.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Empowerment model to Diabetes<br>Empowerment model to improve dietary intake | Behavioral: Empowerment model to improve dietary intake<br>* Empowerment model using specific guidelines to improve dietary intake<br>|
| Active Comparator: Control group following conventional approach<br>Control group following conventional approach | Other: Control group following conventional approach<br>* Control group following conventional approach<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| HbA1C |  | Baseline (week 0), Endline (week 12) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Post Prandial blood glucose |  | Daily for 12 weeks | 
| Fasting Blood Glucose |  | Daily for 12 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
HbA1C
Coexistence HBsAg/HBcAC, Clinical Characterístics & Outcomes

Study Overview
=================
Brief Summary
-----------------
HBV infection is a dynamic process with complex interactions between virus replication and the host's immune response. The appearance of anti-HBs after HBV infection generally indicates recovery and immunity to HBV1 infection. However, there are several published studies that describe the coexistence of the marker of chronic infection (HBsAg +) and the marker of functional cure (HBsAc +). There are contradictory studies on whether the coexistence of HBsAg/HBsAc implies a different clinical course.

Official Title
-----------------
Characteristics of Hepatitis B HBsAg & HBsAc Carriers Simultaneously

Conditions
-----------------
Hepatitis B

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: all those patients who have been seen in outpatient hepatology consultations and who present positive HBsAg and HBsAc serology simultaneously. Exclusion Criteria: Hepatitis C or HIV Co-infection

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Not apply<br>None. Just registration epidemiology dates | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| prevalence concomitant HBsAg and HBsAc markers | To describe the prevalence of concomitant HBsAg and HBsAc markers in our area | 10 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| differences between immunocompetent patients with respect to immunocompromised ones. | To compare if there are differences in the prevalence or clinical outcome according if the patient has any degree of immunosupresion or not. | 10 years |
Radiation Dosimetry in Teeth

Study Overview
=================
Brief Summary
-----------------
Irradiation of any tissue creates changes in that tissue. Ionizing radiation imparts charges to the tissue as it interacts with tissue components, changing the tissue structure. The specific type of modification also depends to some extent upon the type of tissue irradiated. It has been shown that it is possible to read the tooth enamel irradiation record using techniques such as electron paramagnetic resonance (EPR), or electron spin resonance (ESR). It is proposed to examine radiation responses in approximately one hundred (100) human teeth. This would include teeth free of, as well as those containing, amalgam (silver) restorations. For the first group, teeth that have already been collected (pre-existing pathological specimens) would be used. These teeth were surgical/pathological discards collected without identifiers by the dental providers.

Official Title
-----------------
Radiation Dosimetry in Teeth

Conditions
-----------------
Radiation Tolerance

Intervention / Treatment
-----------------
* Radiation: Exposure to irradiation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Discarded pathologic specimens (teeth)
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Radiation: Exposure to irradiation|Treatment for Cancer using Radiation -dose will be the standard of Care for the type of Cancer being treated|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Longitudinal Follow Up of Subjects Enrolled in Randomized Trial of Prenatal and Infancy Home Visitation

Study Overview
=================
Brief Summary
-----------------
The Elmira follow-up study is designed to assess the extent to which prenatal and infancy home visitation by nurses affects the life-course development of 19-year-old youth whose mothers received those services during pregnancy and the first two years of the child's life.

Official Title
-----------------
Longitudinal Follow Up of Subjects Enrolled in Randomized Trials of Prenatal and Infancy Home Visitation

Conditions
-----------------
Risk Reduction Behavior, Reproductive Behavior

Intervention / Treatment
-----------------
* Behavioral: nurse home visitation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Pregnant women prior to the 25th week of gestation no previous live births one of the following sociodemographic risk characteristics: young age (< 19 years at registration); unmarried low socioeconomic status (Medicaid status or no private insurance)
Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Control Group<br>Control Group | |
| Experimental: Home visitation through pregnancy<br>Nurse home visitation through pregnancy | Behavioral: nurse home visitation<br>* Nurse home visitation<br>|
| Experimental: Home visitation through age 2<br>Nurse home visitation through child age 2. | Behavioral: nurse home visitation<br>* Nurse home visitation<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| rates of pregnancy and out-of-wedlock child birth |  | At age 19 | 
| educational achievement, including graduation from high school and participation in various types of post-high school education |  | At age 19 | 
| participation in the work force, including enrollment in the armed services |  | At age 19 | 
| use of welfare |  | At age 19 | 
| use of substances (cigarettes, alcohol, and illegal drugs) |  | At age 19 | 
| involvement with the criminal justice system (arrests, convictions, incarcerations, etc.) |  | At age 19 |
HIAS II - Study of Nutritional Supplementation in Hospitalized Children With Persistent Diarrhea or Malnutrition

Study Overview
=================
Brief Summary
-----------------
This study will determine the effect of 7 days supplementation of alanyl-glutatime or glycine on the damaged intestinal barrier function on day 8 in children with persistent diarrhea or malnutrition.

Detailed Description
-----------------
The purpose of this study is to determine the effect of 7 days supplementation of alanyl-glutamine or glycine on the damaged intestinal barrier function, measured by lactulose/mannitol test on day 8, in children with persistent diarrhea or malnutrition; on diarrhea frequency and duration, weight gain, protein loss, intestinal inflammation, and lactoferrin excretion.

Official Title
-----------------
Prospective Double Blind Randomized Clinical Trial of Alanyl-Glutamine or Glycine in Hospitalized Children With Persistent Diarrhea or Malnutrition.

Conditions
-----------------
Diarrhea, Malnutrition, Other Nutritional Deficiencies

Intervention / Treatment
-----------------
* Drug: Alanyl-glutamine
* Drug: Glycine


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Children ages 3 to 36 months with a history of persistent diarrhea (3 or more unformed stools/day) for >2 weeks or height-for-age Z-score (HAZ) less than negative 1, which is the median of HAZ score in children at HIAS. Be an inpatient and willing to stay for 7 nights at HIAS. Child´s parent or guardian must sign informed consent.. Exclusion Criteria: Children exclusively breast-fed (Reason: The diet needs to be controlled in order to evaluate the study treatment effect) Children who participated in the community study or any other study within the past two years (Reason: The children in the community study will have received glutamine.) Children with suspected other illnesses as indicated by fever >102º F at time of screening off antipyretics Children with suspected systemic disease at the time of screening including but not limited to shock, meningitis, sepsis, pneumonia, tuberculosis, varicella Severe malnutrition defined as HAZ <-3 or WAZ <-3.5 or any child weighing <10 lbs. (4.5 kg) or any child with a weight-to-height ratio <60% of the NCHS age adjusted norm.

Ages Eligible for Study
-----------------
Minimum Age: 3 Months
Maximum Age: 3 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Alanyl-glutamine|nan|
|Drug: Glycine|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Malnutrition, pediatric, Brazil, alanyl-glutamine
Analysis of Visual Pathways in Glaucoma Patients Using a 3tesla-MRI

Study Overview
=================
Brief Summary
-----------------
Glaucoma is a neurodegenerative disease representing the second cause of blindness worldwide. IOP (Intra occular pressure) is the most common risk factor, but not the only one as it is observed for normal tension glaucoma. Some studies have reported lesions of the optical pathways on MRI examination MRI 3T (Magnetic Resonance Imaging 3 Telsa), by increasing spatial resolution and DTI (diffusion tensor Imaging)with fractional anisotropy could help us to analyze visual pathways and to determine the association with neurodegenerative diseases as Alzheimer. The investigators propose to compare volume and structure of the visual pathways between glaucoma patients and healthy subjects matched on age and sex. Glaucoma is a neurodegenerative disease characterized by loss of retinal ganglion cells, visual field deterioration and optic nerve cupping. Some studies have suggested that all the visual pathways could be damaged in glaucoma. Recently, a German study proved a significant reduction of volume of the optic radiations in glaucoma versus healthy subjects in MRI 3T. Some authors have also suggested that glaucoma could share similarities with the other neurodegenerative diseases like Alzheimer's disease. MRI 3T and DTI allow studying visual pathways with a high level of spatial resolution.Fractional anisotropy is a tag of microstructure.

Conditions
-----------------
Fractional Anisotropy, Glaucoma

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: for cases : Age over 40 years-old, glaucomatous lesion of the optic nerve head with cup/disc ratio, visual field loss, and minimental state superior or equal to 28/30 for healthy subjects/ matched on age and sex, no individual or familial history of glaucoma, IOP less than 21mmHG, minimental state superior or equal to 28/30 Exclusion Criteria: Ocular hypertension, optic nerve disease, visual field loss, diabetes, Horton disease, ocular diseases, immunologic diseases, neuropsychiatric diseases, MRI contraindication (pace maker)

Ages Eligible for Study
-----------------
Minimum Age: 40 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Glaucoma subjects<br> | |
| heathly subjects<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| fractional anisotropy |  | Inclusion | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| volume of retrochiasmatic grey matter |  | Inclusion | 
| global atrophy |  | inclusion | 
| hyper intensities white matter |  | inclusion |
Tetralogy of Fallot Seed Grant

Study Overview
=================
Brief Summary
-----------------
Patients with pulmonary regurgitation after surgical correction of ToF over 13 years old will be recruited from the UCSF adult congenital heart disease clinic. Since there is no data in the literature describing the prevalence of abnormal MRI volumetric and functional parameters in asymptomatic patients with PR after ToF repair, a pilot study with 30 patients will be conducted. Increase in sample size may be necessary in the future to accurately interpret the data. After informed consent is obtained, clinical history and physical examination as well as review of old charts will be performed to characterize these patient's clinical status. All patients will undertake a graduated supine bicycle exercise test with MVO2 measurement to assess exercise capacity. MRI studies will be performed in a 1.5 tesla unit. SSFP cine images will be obtained in the short-axis plane encompassing the entire heart. Velocity-encoded cine MR images will be obtained perpendicular to the direction of blood flow in the main pulmonary artery. Volumetric and flow analysis will be performed in a separate dedicated workstation by a radiologist. End-diastolic volume, end-systolic volume, ejection fraction, total ejection fraction and pulmonary regurgitant fraction will be calculated.

Official Title
-----------------
MRI Assessment of Right Ventricular Function in Patients After Repair of Tetralogy of Fallot

Conditions
-----------------
Pulmonary Regurgitation After Repair of Tetralogy of Fallot

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients over 13 years of age with pulmonary regurgitation after surgical correction of tetralogy of Fallot. Adult patients with pulmonary regurgitation after surgical repair of tetralogy of Fallot who are under follow-up at the adult congenital heart disease clinic at UCSF or Pediatric patients with pulmonary regurgitation after surgical repair of tetralogy of Fallot who are under follow-up at the pediatric congenital heart disease clinic at UCSF and are referred for a clinically indicated cardiac MRI studies or Adult and pediatric patients with pulmonary regurgitation after surgical repair of tetralogy of Fallot who are referred for clinically indicated MRI studies at UCSF. Exclusion Criteria: Contraindication for MRI study. Claustrophobia.

Ages Eligible for Study
-----------------
Minimum Age: 13 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Pulmonary Regurgitation, Tetralogy of Fallot