Effect of Autogenous Leukocyte Platelet Rich Fibrin- Tooth Graft Combination Around Immediately Placed Implants

Study Overview
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Brief Summary
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Immediate implant placement into fresh extraction sockets is gaining popularity because of fewer clinical procedures and maintenance of bone architecture compared to conventional methods, thus reducing the treatment time and increasing patient satisfaction. In addition, the survival rate of the immediate implantation is comparable to that of the healed implantation sites. Recently, ATBG made from compromised teeth was applied in bone defects and resulted in a good clinical efficacy. Moreover, it is more accepted by patients to use extracted teeth as a bone graft material, especially in the case of immediate implant placement. In 2020, Kizildağ and coworkers studied the outcome of PRF as an adjunct with ATBG on bone healing in rabbit peri-implant osseous defects. They reported that combination of ATBG with PRF contributed to significantly higher new bone formation and better bone/implant contact in rabbits with peri-implant bone defects. The main hypothesis behind this study is that using L-PRF with ATBG following immediate implant placement could promote stabilization of graft particles and enhance new bone formation with a shorter time. Therefore, the purpose of this study was to compare the clinical and radiographic outcomes of ATBG on bone formation with or without L-PRF around immediately placed dental implants in periodontally compromised teeth.

Official Title
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Effect of Autogenous Leukocyte Platelet Rich Fibrin- Tooth Graft Combination Around Immediately Placed Implants in Periodontally Compromized Sites: A Randomized Clinical Trial

Conditions
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Autogenous Tooth Bone Graft, Immediate Implant Placement, L-PRF

Intervention / Treatment
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* Combination Product: immediate implant placement with ATBG and L-PRF
* Combination Product: immediate implant placement with ATBG


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Teeth need to be extracted for periodontal reasons with a defect of labial bone (horizontal or vertical bone defect). the teeth without acute inflammation. no uncontrolled systemic disease which is not suitable for implantation. Good systemic and oral health. Exclusion Criteria: patients with systemic diseases or medications known to alter healing processes Psychiatric disorders. Root canal treated teeth. patients undergoing or who had undergone radiation therapy and chemotherapy to the head and neck region during 12 months. patients with para-functional habits. alcoholics. drug abusers. heavy smokers

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: L-PRF with ATBG around implant<br>L-PRF clots to cover ATBG around immediately placed dental implants in the extraction sockets | Combination Product: immediate implant placement with ATBG and L-PRF<br>* immediate implant placement using ATBG as a graft material, with L-PRF<br>|
| Active Comparator: ATBG around implant<br>ATBG around immediately placed dental implants in the extraction sockets | Combination Product: immediate implant placement with ATBG<br>* immediate implant placement using ATBG as a graft material without L-PRF<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| clinical evaluation of bone formation around immediately placed dental implants | Changes on bone formation using ATBG with or without L-PRF around immediately placed dental implants in periodontally compromised teeth | 9 months | 
| radiographic outcome around immediately placed dental implants | the radiographic outcome of ATBG on bone formation with or without L-PRF around immediately placed dental implants in periodontally compromised teeth | 9 months |