Influence of PRGF (Plasma Rich in Growth Factors) Puncture in Ovaries With Low Follicular Reservetechniques

Study Overview
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Brief Summary
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Assisted reproduction patients candidates to an IVF/ICSI cycle with low follicular reserve: after at least one cycle of stimulation obtaining 0-4 oocytes. Improve the follicular response in patients with low response, increasing the number of follicles in subsequent cycles to treatment with growth factors.

Official Title
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Influence of PRGF (Plasma Rich in Growth Factors) Puncture in Ovaries With Low Follicular Reserve

Conditions
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Low Ovarian Reserve

Intervention / Treatment
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* Drug: Growth Factors


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients must give written consent. To be a healthy woman acting voluntarily, aged 18 to 42 years (both inclusive) at the time of study selection time of selection for the study. Have a BMI ≥ 18 kg/m2 and ≤ 35 kg/m2 Patients with low ovarian reserve (AMH <1.1 ng/mL) according to the Bologna criteria. Patients who are going to undergo IVF/ICSI cycle with low follicular response: who after a previous cycle of stimulation have obtained 0-3 or more follicular 0-3 oocytes have been obtained after a previous stimulation cycle; or if 0-3 oocytes are expected to be obtained at the present time (less than 4 follicles). oocytes (less than 4 follicles in the basal ultrasound). To have recent analytical results (haemogram, biochemistry and coagulation); at least 11 months prior to inclusion in the study and a serology, according to clinical practice. Translated with www.DeepL.com/Translator (free version)

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 42 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Instillation of growth factors<br>Patients candidates to an IVF/ICSI cycle with low follicular reserve: after at least one cycle of stimulation obtaining 0-3 oocytes. | Drug: Growth Factors<br>* one dose 3-6 mL of PRP obtained by PRGF Endoret<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of follicles recruited after instability of ovarian growth factors | o demonstrate an increase of at least 20% in the number of MII oocytes in a cycle after IVF/ICSI treatment with PRGF®-Endoret® compared to previous cycles in low IVF/ICSI patients. IVF/ICSI treatment with PRGF®-Endoret® with respect to previous cycles in low responders. responders | two months; Time included in two protocols of ovarian stimulation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rates of pregnancy rates | Increase pregnancy rates and decrease the number of cycles of accumulation of oocytes. | three months after embryo transfer after treatment of growth factors |