Use of 2-octylcyanoacrylate (Dermabond) Versus 5-0 Fast Absorbing Gut During Cutaneous Wound Closure

Study Overview
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Brief Summary
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The purpose of this study is to determine whether the use of 2-octylcyanoacrylate during repair of linear cutaneous surgery wounds improves scar cosmesis compared to wound closure with 5-0 fast absorbing gut.

Detailed Description
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The purpose of this study is to determine whether the use of 2-octylcyanoacrylate during repair of linear cutaneous surgery wounds improves scar cosmesis compared to wound closure with 5-0 fast absorbing gut. The investigators will use a split wound model, where half of the wound is treated with 2-octylcyanoacrylate and the other half is repaired with 5-0 fast absorbing gut. Three-months post-surgery, the scar will be measured via the physician observer scar assessment scale, a validated scar instrument. The scar width, and adverse events will also be recorded.

Official Title
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Use of 2-octylcyanoacrylate (Dermabond) Versus 5-0 Fast Absorbing Gut During Cutaneous Wound Closure: a Randomized Evaluator Blinded Split Wound Comparative Effectiveness Trial

Conditions
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Wound Closure Techniques

Intervention / Treatment
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* Procedure: Wound Closure with 2-octylcyanoacrylate
* Procedure: Wound Closure with 5-0 Fast Absorbing Gut Sutures


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 18 years of age or older Able to give informed consent themselves Patient scheduled for cutaneous surgical procedure with predicted linear closure of 3 cm of longer. Willing to return for follow-up visits Exclusion Criteria: Mentally handicapped Unable to understand written and oral English Incarceration Under 18 years of age Pregnant Women Wounds with predicted closure length less than 3 cm

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Wound Closure with 2-octylcyanoacrylate<br>One side of the patient's wound defect will be assigned to wound closure with 2-octylcyanoacrylate liquid bonding agent). | Procedure: Wound Closure with 2-octylcyanoacrylate<br> <br> Procedure: Wound Closure with 5-0 Fast Absorbing Gut Sutures<br> <br> |
| Active Comparator: Wound Closure with 5-0 Fast Absorbing Gut<br>One side of the patient's wound defect will be assigned to wound closure with 5-0 fast absorbing gut sutures. | Procedure: Wound Closure with 2-octylcyanoacrylate<br> <br> Procedure: Wound Closure with 5-0 Fast Absorbing Gut Sutures<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Assessment of Scar on the Patient and Observer Scar Assessment Scale | After surgical procedure, half of the subject's wound will be with 2-octylcyanoacrylate, while the other half is closed 5-0 fast absorbing gut sutures. After 3 months, subjects will return to clinic for evaluation of the cosmesis of both types of closure techniques. | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measurement of Scar Width | The width of the scar will be measured 1 centimeter from the midline on both sides. There is no defined width that is considered satisfactory or not satisfactory. The measurements will be compared between subjects. | 3 months | 
| Assessment of Complications | Noting the presence or absence of bleeding, dehiscence, infection or spitting sutures. | 3 months |