Reversal of Neuromuscular Blockade in Diabetic Patients

Study Overview
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Brief Summary
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In this study the investigators aimed to compare the time of antagonism and intensity of effect of sugammadex which is used for antagonism of rocuronium on diabetic and non-diabetic patients.

Detailed Description
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Aim: In this study the investigators aimed to compare the time of antagonism and intensity of effect of sugammadex which is used for antagonism of rocuronium on diabetic and non-diabetic patients. Methods: Included patients were divided into 2 groups: diabetic (n=21) and non-diabetic (n=20). All patients were premedicated. After arrival in the operating room, all patients were monitorised with Datex Ohmeda S/5 Anesthesia Machine and electrocardiography (DII derivation), hemodynamic variables, respiratory rate, and inspiratory sevoflurane concentrations were recorded. Neuromuscular monitoring system was used. Anesthesia was induced with propofol 2 mg/kg and fentanyl 1 mcg/kg. After the loss of eyelid reflex the neuromuscular monitoring system automatically identified supramaximal stimulating currents and after that rocuronium 0,6 mg/kg was given. Train of four (TOF) stimulation with the supramaximal current were applied and by recording of second TOF value (TOF2) the patient was intubated. Anesthesia was maintained with 50% O2 + 50% air and sevoflurane of 1-2 % concentration. TOF stimulation was applied and recorded every 20 seconds. Intraoperatively by return T2 rocuronium 0,15 mg/kg was given. T2i time was recorded as intubation time and T2d time was recorded as clinical effect time. At the end of the operation sugammadex 2 mg/kg was given. When TOF rate reached 0,9 patients were extubated and the time was recorded.

Official Title
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The Comparison of Reversal of Neuromuscular Blockade in Diabetic and Non-Diabetic Patients

Conditions
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Observation of Neuromuscular Block

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: The patients (diabetic and non-diabetic) between 18-65 years with risk of anesthesia I-II, For diabetic group patients with Diabetes mellitus Type 2 over 10 years. For non-diabetic group patients without any glucose metabolism disease Exclusion Criteria: myasthenia gravis, myotonic dystrophia, motor neuron diseases diabetic neuropathy and nephropathy hepatic, renal and cardiac diseases

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| non-diabetic<br>non-diabetic group; 2 mg/kg sugammadex iv, postoperatively Extubation times were recorded. | |
| diabetic<br>Diabetic group; 2 mg/kg sugammadex iv, postoperatively Extubation times were recorded | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| reversal of diabetic patients | T2i time was recorded as intubation time and T2d time was recorded as clinical effect time. At the end of the operation sugammadex 2 mg/kg was given. When TOF rate reached 0,9 patients were extubated and the time was recorded. | 24 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| hemodynamic changes | Systolic, diastolic blood pressure and heart rate were recorded in the peroperative period | 24 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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diabetes mellitus, neuromuscular blockade, sugammadex