Description of Ophthalmologic Injuries in Intensive Care During the SARS-CoV2 Epidemic - COVID19

Study Overview
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Brief Summary
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The management of patients with SARS-CoV2 in respiratory distress can expose to corneal or retinal lesions induced by the stay in intensive care. Examination by ophthalmologists would make it possible to detect the most of the ophthalmologic problems known in intensive care and to provide an early, preventive or curative therapeutic response when possible, in order to avoid irreversible visual loss. The object of the research is to assess the presence and the importance of surface ophthalmologic lesions, the presence and the importance of retinal or optic nerve lesions, in order to improve the monitoring and primary prevention of this population

Official Title
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Description of Ophthalmologic Injuries in Intensive Care During the SARS-CoV2 Epidemic - COVID19

Conditions
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Covid19, Sars-CoV2

Intervention / Treatment
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* Procedure: Ophthalmologic exam


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patient SARS-CoV2 positive (RT-PCR or chest scanner) hospitalized in intensive care Exclusion Criteria: traumatic lesion of the face or any other condition preventing any ophthalmological evaluation

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Ophthalmologic exam<br> | Procedure: Ophthalmologic exam<br>* Direct exam and Slit lamp exam Shirmer test Retinophotography At inclusion, day 7, day 14 and discharge from hospital<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Describe ophthalmologic damage to the cornea with direct exam at day 0 | Direct exam | Day 0 | 
| Describe ophthalmologic damage to the cornea with direct exam at day 7 | Direct exam | Day 7 | 
| Describe ophthalmologic damage to the cornea with direct exam at day 14 | Direct exam | Day 14 | 
| Describe ophthalmologic damage to the cornea with direct exam at discharge of hospital | Direct exam | Discharge of hospital, up to 3 months | 
| Describe ophthalmologic damage to the cornea with slit lamp exam at day 0 | Slit lamp exam | Day 0 | 
| Describe ophthalmologic damage to the cornea with slit lamp exam at day 7 | Slit lamp exam | Day 7 | 
| Describe ophthalmologic damage to the cornea with slit lamp exam at day 14 | Slit lamp exam | Day 14 | 
| Describe ophthalmologic damage to the cornea with slit lamp exam at discharge of hospital | Slit lamp exam | Discharge of hospital, up to 3 months | 
| Describe tear film anomalies at day 0 | Shirmer test | Day 0 | 
| Describe tear film anomalies at day 7 | Shirmer test | Day 7 | 
| Describe tear film anomalies at day 14 | Shirmer test | Day 14 | 
| Describe tear film anomalies at discharge of hospital | Shirmer test | Discharge of hospital, up to 3 months | 
| Describe ophthalmologic damage to the retina at day 0 | Retinophotography | Day 0 | 
| Describe ophthalmologic damage to the retina at day 7 | Retinophotography | Day 7 | 
| Describe ophthalmologic damage to the retina at day 14 | Retinophotography | Day 14 | 
| Describe ophthalmologic damage to the retina at discharge of hospital | Retinophotography | Discharge of hospital, up to 3 months | 
| Describe ophthalmologic damage to the optic nerve at day 0 | Retinophotography | Day 0 | 
| Describe ophthalmologic damage to the optic nerve at day 7 | Retinophotography | Day 7 | 
| Describe ophthalmologic damage to the optic nerve at day 14 | Retinophotography | Day 14 | 
| Describe ophthalmologic damage to the optic nerve at discharge of hospital | Retinophotography | Discharge of hospital, up to 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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ophthalmological lesions