Comparison of Carotid Peak Systolic Velocity Variation With Aortic Peak Systolic Velocity Variation in Pediatric Non-Cardiac Surgery

Study Overview
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Brief Summary
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The purpose of this study is to evaluate whether carotid Doppler peak systolic velocity can be an easy to measure possible surrogate for echocardiographic measurement of aortic peak systolic velocity variation which is an index of fluid responsiveness in mechanically ventilated children intra-operatively.

Official Title
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Comparison of Carotid Peak Systolic Velocity Variation With Aortic Peak Systolic Velocity Variation in Pediatric Non-Cardiac Surgery

Conditions
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Anesthesia, General, Anesthesia, Endotracheal, Mechanical Ventilation, Fluid Responsiveness

Intervention / Treatment
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* Other: Measurement of aortic and carotid Doppler peak systolic velocity variation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: • Patients scheduled for mon-cardiac surgeries under general endotracheal anaesthesia in supine position with expected duration more than 1 hour Exclusion Criteria: Known congenital heart disease Any non-sinus rhythm, arrhythmias Patients on vasoactive medications Chest wall deformities, situs non solitus (eg. dextrocardia) Patients scheduled for open chest surgeries History of neck surgery/ carotid interventions

Ages Eligible for Study
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Minimum Age: 1 Year
Maximum Age: 12 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental<br>Children aged 1-12 years undergoing major surgeries under general endotracheal anaesthesia with mechanical ventilation under neuromuscular blockade | Other: Measurement of aortic and carotid Doppler peak systolic velocity variation<br>* Aortic peak systolic velocity variation to be measured by echocardiography from apical five chamber and suprasternal windows alongwith carotid peak systolic velocity variation by Doppler ultrasound simultaneously at intermittent time points intermittently.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of carotid peak systolic velocity variation with aortic peak systolic velocity variation | Comparison of carotid peak systolic velocity variation with aortic peak systolic velocity variation by Bland-Altman analysis | Measurements made within 3 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between aortic peak systolic velocity variation measured from apical and suprasternal windows | Correlation between aortic peak systolic velocity variation measured from apical and suprasternal windows by Bland-Altman analysis | Measurements made within 3 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Fluid Responsiveness, Pediatric surgery, General endotracheal anaesthesia