linjc16/ctgov huggingface dataset:
Treatment and Outcomes of Stage III Colon Cancer in Patients 80 Years of Age and Older

Study Overview
=================
Brief Summary
-----------------
The objective of this study was to assess survival trends in elderly patients with stage III colon cancer

Detailed Description
-----------------
This retrospective population-based study included patients aged 80 years and older with stage III colon adenocarcinoma who underwent surgery between 2007 and 2014.

Official Title
-----------------
Treatment and Outcomes of Stage III Colon Cancer in Patients 80 Years of Age and Older

Conditions
-----------------
Colon Adenocarcinoma

Intervention / Treatment
-----------------
* Other: observational


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: • Stage 3 colon adenocarcinoma Exclusion Criteria: Rectal tumors Patients receiving neo-adjuvant chemotherapy or radiotherapy Tumours of the appendix Tumours with histology other than adenocarcinoma

Ages Eligible for Study
-----------------
Minimum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Stage 3 with adjuvant chemotherapy<br> | Other: observational<br>* observational<br>|
| Stage 3 without adjuvant chemotherapy<br> | Other: observational<br>* observational<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overall survival | months | 2007-2014 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
stage 3 colon cancer, elderly, survival, surgery, chemotherapy
Escitalopram and Depression in Elderly Alzheimer's Patients

Study Overview
=================
Brief Summary
-----------------
To investigate the effect of Escitalopram in a large and diverse of dementia patients suffering from depression.

Detailed Description
-----------------
This study will assess the efficacy, tolerability, and safety of escitalopram in the treatment of Major Depressive Disorder in patients with Alzheimer's disease over a 24-week period. It will also assess the efficacy and tolerability of escitalopram after 12 weeks of treatment.

Official Title
-----------------
An Open-label Study of Escitalopram in the Treatment of Major Depressive Disorder in Elderly Patients With Alzheimer's Disease

Conditions
-----------------
Depressive Disorder

Intervention / Treatment
-----------------
* Drug: Escitalopram


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: > 50 years Male & female Alzheimer's disease Depressive episode

Ages Eligible for Study
-----------------
Minimum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Escitalopram|See Detailed Description.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Cornell Scale for Depression in Dementia (CSDD) from baseline. |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Montgomery-Åsberg Depression Rating Scale; Neuropsychiatric Inventory; Alzheimer's Disease Cooperative Study |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Alzheimer's disease, elderly, open-label, escitalopram
Observation of Blood Orphanin and Norepinephrine Levels in Diabetic Patients Under Subarachnoid Anesthesia

Study Overview
=================
Brief Summary
-----------------
This study aims to investigate the Influence of Intraspinal anesthesia to the concentrations of blood orphanin, norepinephrine in patients with diabetes mellitus. We hope to explain the relationship between sensory and sympathetic nerves in diabetic patients undergoing intraspinal anesthesia.

Official Title
-----------------
Effect of Subarachnoid Anesthesia on Blood Orphanin and Norepinephrine in Diabetic Patients

Conditions
-----------------
Intraspinal Anesthesia

Intervention / Treatment
-----------------
* Diagnostic Test: ELISA


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients undergoing lower limb surgery under spinal anesthesia Exclusion Criteria: Emergency surgery The operation time is more than 3 hours Combined general anesthesia or nerve block anesthesia

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Diabetes mellitus group<br>Diabetic patients undergoing spinal anesthesia for lower extremity surgery | Diagnostic Test: ELISA<br>* Detection of blood orphanin and norepinephrine in patients<br>|
| Non-diabetic group<br>Non-diabetic patients undergoing spinal anesthesia for lower extremity surgery | Diagnostic Test: ELISA<br>* Detection of blood orphanin and norepinephrine in patients<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood orphanin concentration | Concentration of blood orphanin in patients before and after anesthesia | 24 hours | 
| Blood norepinephrine concentration | Concentration of blood norepinephrine in patients before and after anesthesia | 24 hours |
The Effect of Vitamin D and Calcium Supplementation on the Prevention of Stress Fractures.

Study Overview
=================
Brief Summary
-----------------
The main objective of this study is to find whether supplemental vitamin d and calcium can reduce the incidence of stress fractures in recruits. These high-risk recruits undergo intensive training which elevated bone turnover, which requires adequate level of vitamin D and calcium in order to support bone health. It is hypothesized that supplemental vitamin d and calcium will decrease the occurrence of stress fractures.

Official Title
-----------------
The Effect of Vitamin D and Calcium Supplementation on the Prevention of Stress Fractures in Chinese Recruits.

Conditions
-----------------
Stress Fracture, Vitamin d

Intervention / Treatment
-----------------
* Drug: Vitamin D, Calcium
* Drug: Placebo


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Recruits newly enlisted at a training base in September 2021. Agree to accept relevant inspections and serological research, and sign an informed consent form. Exclusion Criteria: Suffer from diabetes, osteomyelitis and other diseases. Suffer from claustrophobia and other MRI examination contraindications. Long-term use of glucocorticoids, non-steroidal anti-inflammatory drugs or calcium, vitamin D. A history of kidney disease. Allergic to any ingredient of the medicine.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 25 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Experimental (Treatment) Group<br>Oral vitamin D1000IU, 1/day, calcium 1200mg, 1/day, for 8 weeks. | Drug: Vitamin D, Calcium<br>* Vitamin D, calcium are available in tablets. During the 8 weeks of training, subjects were asked to take supplement tablets per day after dinner.<br>|
| Placebo Comparator: Control Group<br>Oral placebo, for 8 weeks. | Drug: Placebo<br>* Placebo<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Stress fracture | Stress fractures were recorded when recruits reported to the clinic with suspected symptoms. All stress fractures were confirmed with radiography or Magnetic Resonance Imaging(MRI). Each subject with a stress fracture was recorded. | 3 months after the start of the basic military training. |
Effects of Dance on Reaction Time in Experienced Older Adults

Study Overview
=================
Brief Summary
-----------------
Aim of this study was to investigate the effects of 6-month ballroom dance (3 times/wk) on physical fitness and reaction time in twenty- four experienced older adults. Body composition, handgrip test, standing long jump test, step test, one-legged stance balance test, and reaction time (RT) test were assessed before and after 6 months (T6) of dance practice. RT was re-evaluated after 4 months (T10).

Official Title
-----------------
Effects of Ballroom Dance on Physical Fitness and Reaction Time in Experienced Older Adults

Conditions
-----------------
Aging

Intervention / Treatment
-----------------
* Other: partnered dance


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: dance practice (dance average years = 11 years) Exclusion Criteria: functional inabilities cardiovascular diseases prosthesis
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: participants<br>to analyze the effects of 6-month ballroom dance (3 times/wk) on physical fitness and reaction time in twenty-four experienced older adults | Other: partnered dance<br>* Dance classes consisted of different choreographies, which include rhythmic and simple movements typically of ballroom/standard dances (Waltz, Tango, Viennese Waltz).<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change From Baseline in Reaction time at 6 Months | reaction time was assessed with the subject seating with the arm resting on a table in a comfortable position and then catches the apparatus as quickly as possible after it begins to fall. The fall distance was measured and it was converted into a reaction time (in milliseconds) using the formula for a body falling under the influence of gravity (d 5 1⁄2gt2), where d is distance, g is acceleration due to gravity, and t is time. | baseline, 6 months and 10 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
physical activity, partnered dances, cognitive functions, fall prevention
Characterization of Disease Related Changes in Inflammatory Bowel Disease Using Fecal Metabolite Profiling

Study Overview
=================
Brief Summary
-----------------
The purpose of the study is to evaluate fecal metabolites profiles of Inflammatory Bowel Disease(IBD) patients versus healthy controls (HC).

Official Title
-----------------
Characterization of Disease Related Changes in Inflammatory Bowel Disease Using Fecal Metabolite Profiling

Conditions
-----------------
Inflammatory Bowel Diseases

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Clinical diagnosis of IBD Age >18 years Exclusion Criteria: Use of antibiotics in the preceding month Intake of pre- or probiotics

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Healthy controls (HC)<br>HC | |
| Inflammatory Bowel Disease (IBD) patients<br>Crohn's disease (CD), Ulcerative colitis (UC) and pouchitis | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Retinal Oxygen Saturation in Patients With Graves' Ophthalmopathy and in Normal People

Study Overview
=================
Brief Summary
-----------------
Find if the retinal function is affected in both the nonsevere and the severe stage of Graves' ophthalmopathy (GO) by comparing the retinal oxygen saturation of GO patients with that of normal people.

Detailed Description
-----------------
Graves'ophthalmopathy (GO), also called thyroid-associated ophthalmopathy, is often mild and self-limiting, and probably declining in frequency, with only 3-5% of cases posing a threat to eyesight, remaining a pathogenetic enigma and a therapeutic dilemma. In its nonsevere expression, the symptoms and signs include Photophobia, Foreign body sensation, Eyelid retraction, increased intraocular pressure, Lagophthalmos, and Mild diplopia. In its severe expression, it is a disfiguring and invalidating disease with the optic nerve damaged. However, in this study, we want to find if the retinal vessels is affected in the early stage of the disease through observing the oxygen saturation of the retinal vessels and compare it with that of the normal people.

Official Title
-----------------
Changes of Retinal Oxygen Saturation in Patients With Graves' Ophthalmopathy Under Different Managing Conditions and in Normal People

Conditions
-----------------
Graves' Ophthalmopathy

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria for GO patients: conforms to the diagnosis of Graves' ophthalmopathy; age > 18; volunteered to participate in this research, and sign the informed consent. Inclusion Criteria for Control group: age > 18; diopter within + / - 3D; volunteered to participate in this research, and sign the informed consent. Exclusion Criteria for GO patients: Fundus could not be seen clearly; pregnant and lactating women; could not tolerate the examination. Exclusion Criteria for Control group: with severe systemic disease and cause eye lesions; have history of eye disease, ocular trauma and eye surgery impacting on visual function; pregnant and lactating women; could not tolerate the examination.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| controls<br>People without eye disease | |
| GO patients<br>patients with Graves' ophthalmopathy | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| changes of retinal oxygen saturation in patients with GO under different managing conditions |  | before surgery ( or glucocorticoids administration), 1 week and 4 weeks after surgery ( or glucocorticoids administration) | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
oxygen saturation, retinal vessels, thyroid associated ophthalmopathy
Executive Reaction Time Test in Assessment of Cognitive Dysfunction After Aortic Valve Procedures

Study Overview
=================
Brief Summary
-----------------
Up to 50% of patients undergoing surgical aortic valve operation suffer from some level of post-operative cognitive dysfunction (POCD). Frontal lobes of the brain, where executive functions are located, are highly susceptible to trauma caused by possible blood malperfusion to these areas of the brain during surgery. Conventional and established neuropsychological test methods are poor in distinguishing these kinds of trauma, as they are isolated, structured tests that do not require multitasking and processing of multiple stimuli at the same time. The phase 1 goal of this study is to employ an experimental Executive reaction time (RT) test to see if this method could improve objective detection of subtle brain dysfunction assumed to underlie persistent cognitive, somatic, and affective complaints reported by patients who have undergone electic aortic valve replacement (AVR) surgery. Phase 2 of the study will concentrate on patients undergoing transcatheter aortic valve implantation (TAVI).

Official Title
-----------------
Executive Reaction Time Test in Assessment of Cognitive Dysfunction After Aortic Valve Procedures

Conditions
-----------------
Neurobehavioral Manifestations

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: undergoing elective aortic valve stenosis surgery (phase 1) or transcatheter aortic valve implantation (phase 2) Exclusion Criteria: Previous neurological or psychiatric disorder. Significant visual problem Problems with upper arm/hand use

Ages Eligible for Study
-----------------
Minimum Age: 60 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Executive Reaction Time Test response speed |  | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Executive Reaction Time Test: error% of answers |  | 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
POCD, Executive Reaction Time Test, Aortic valve surgery, Cognitive functions, Transcatheter Aortic Valve Implantation
Ultrasonographic Evaluation of the Diaphragm During NHF Versus NIV Use in Respiratory Failure

Study Overview
=================
Brief Summary
-----------------
This study will describe influence of NHF or NIV to different ultrasonographic parameters of the diaphragm. Therefor subjects will be randomized to the sequence NHF and than NIV or NIV and than NHF. In all subjects same parameters will be evaluated.

Official Title
-----------------
Ultrasonographic Evaluation of the Diaphragm During NHF Versus NIV Use in Respiratory Failure

Conditions
-----------------
Diaphragm Issues, Respiratory Failure With Hypoxia, Respiratory Failure With Hypercapnia, Non-invasive Mechanical Ventilation

Intervention / Treatment
-----------------
* Diagnostic Test: DTEE
* Diagnostic Test: DTEI
* Diagnostic Test: DEx


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: acute or chronic respiratory failure, hyperemic or hypercapnic age > 18 yrs written consent Exclusion Criteria: critical disease (intubation, heart failure, lung edema,..) no compliance metabolic acidosis

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: NHF-NIV<br>Subjects will start with NHF. If all measurements are done, subjects will change to NIV. Same measurements will done. | Diagnostic Test: DTEE<br>* endexpiratory diaphragm thickness in mm<br>Diagnostic Test: DTEI<br>* endinspiratory diaphragm thickness in mm<br>Diagnostic Test: DEx<br>* diaphragm excursion during rest and diaphragmatic excursion during maximal inspiration in mm<br>|
| Experimental: NIV-NHF<br>Subjects will start with NHF. If all measurements are done, subjects will change to NIV. Same measurements will done. | Diagnostic Test: DTEE<br>* endexpiratory diaphragm thickness in mm<br>Diagnostic Test: DTEI<br>* endinspiratory diaphragm thickness in mm<br>Diagnostic Test: DEx<br>* diaphragm excursion during rest and diaphragmatic excursion during maximal inspiration in mm<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in DTEE | Evaluation from baseline and between devices | 10 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in DTEI | Evaluation from baseline and between devices | 10 minutes | 
| Changes in Dex | Evaluation from baseline and between devices | 10 minutes |