Effect of the Intensity of Continuous Renal Replacement Therapy in Patients With Acute Kidney Injury

Study Overview
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Brief Summary
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The current international Continuous Renal Replacement Therapy (CRRT) replacement fluid doses of 35 ml/kg/h is better, but the result is according to white people, black people . It is Whether the best amount of replacement fluid for Chinese people, it is unclear. Especially,there is little evidence about the optimal dose from randomized trials in Cardiac surgery associated acute kidney injury (CSA-AKI )required CRRT,According to the clinical situation, the design of replacement fluid to 25 ml/kg/h.The observation of two doses 14 days, 28 days, 90 days survival and renal function.

Detailed Description
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Acute kidney injury (AKI) is a major complication in patients with cardiac surgery and is an independent predictor of mortality. However, the optimal intensity of renal replacement therapy for such patients is still controversial. we randomly assigned the patients with Cardiac surgery-associated acute kidney injury (CSA-AKI) to continuous renal replacement therapy with different treatment dose (35ml / kg / h or 25ml/kg／h),The primary study outcome was death from any cause within 14, 28 and 90 days.

Official Title
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Effect of the Intensity of Continuous Renal Replacement Therapy in Patients With Cardiac Surgery Associated Acute Kidney Injury (CRITERIA STUDY)

Conditions
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Acute Kidney Injury

Intervention / Treatment
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* Device: CRRT


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: > = 18 years of age, CRRT indications for acute kidney injury (RIFLE criteria) patients with cardiac surgery Exclusion Criteria: < 18 years old, with chronic kidney disease, dialysis history, to leave the ICU patients with acute kidney injury (AKI). - chronic kidney disease, all causes kidney damage (pathology, hematuria, and radiographic abnormalities)> = 3 months or glomerular filtration rate < 60ml/min for 3 months or more.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: high dose (35ml/kg/h)<br>> = 18 years of age, CRRT indications for acute kidney injury (RIFLE criteria) patients with cardiac surgery, was given filtration at a rate of 35 mL/kg/h. | Device: CRRT<br>* Difference dose of CRRT<br>|
| Experimental: low dose (25ml/kg/h)<br>> = 18 years of age, CRRT indications for acute kidney injury (RIFLE criteria) patients with cardiac surgery, was given filtration at a rate of 25 mL/kg/h. | Device: CRRT<br>* Difference dose of CRRT<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| death from any cause | The primary study outcome was death from any cause within 14, 28 ,90 and 365 days after randomization. | 14, 28 ,90 and 365 days after randomization | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| renal outcome of survivors | Secondary outcomes were renal outcome of survivors14, 28 ,90 and 365 days after randomization | 14, 28 ,90 and 365 days after randomization | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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CRRT, cardiac surgery associated acute kidney injury, Intensity