Sorafenib/Docetaxel Dose Escalation Trial

Study Overview
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Brief Summary
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The purpose of this study is to: 1.) Evaluate how your body reacts to sorafenib when taken daily (continuously) in combination with docetaxel given every 3 weeks, and to determine the safety of the two drugs together.2.) Measure your blood levels of sorafenib and docetaxel at specific times after taking the medications.

Official Title
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A Phase I Dose Escalation Study With Sorafenib Administered Continuously in Combination With Docetaxel Administered Once Every Three Weeks in Patients With Advanced Solid Tumors.

Conditions
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Neoplasms

Intervention / Treatment
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* Drug: Sorafenib (Nexavar, BAY43-9006)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age greater than or equal to 18 years Advanced histological or cytological documentation of cancer At least one evaluable lesion ECOG Performance Status of 0 or 1 No more than one prior chemotherapy regimen (prior adjuvant therapy, immunotherapy or hormone treatment are allowed and not restricted) Life expectancy of at least 12 weeks No previous exposure to docetaxel or sorafenib Adequate bone marrow, liver and renal function as assessed by the following: Hemoglobin greater than or equal to 9.0 g/dL Absolute neutrophil count (ANC) greater than or equal to 2,500/mm3 Platelet count greater than or equal to 100,000/mm3 Hepatic Total Bilirubin less than or equal to ULN AST, ALT and Alkaline Phosphatase less than 1.5x ULN. PT-INR/PTT less than 1.5 x ULN (Patients who are being prophylactically anti coagulated with an agent such as coumadin or heparin will be allowed to participate provided that the INR less than 1.5. In addition, these patients must be monitored at appropriate intervals throughout study) Serum creatinine less than or equal to 1.5 x upper limit of normal Exclusion Criteria: Myocardial infarction or symptomatic coronary artery disease (severe or unstable angina) within 6 months prior to screening Active clinically serious infections (> Grade 2 NCI-CTCAE Version 3.0) Uncontrolled seizure disorder. Use of cytochrome P450 enzyme-inducing antiepileptic drugs (phenytoin, carbamazepine or phenobarbital) is not allowed Uncontrolled hypertension defined as systolic blood pressure > 150 mmHg or diastolic pressure > 90 mmHg, despite optimal medical management Known human immunodeficiency virus (HIV) infection or chronic hepatitis B or C Peripheral neuropathy > Grade 1 Thrombotic or embolic events (such as transient ischemic attacks, myocardial infarction, pulmonary embolus), within 6 months prior to screening Major surgery, open biopsy or significant traumatic injury within 4 weeks of first study treatment Pregnant or breast feeding women

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Arm 1<br> | Drug: Sorafenib (Nexavar, BAY43-9006)<br>* Sorafenib 400mg by mouth daily in combination with docetaxel 60mg/m2 IV once every 3 weeks<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To determine the safety, maximum tolerated dose and dose-limiting toxicities of oral sorafenib |  | 6 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To determine if there is a pharmacokinetic interaction between sorafenib and docetaxel when they are administered together |  | 6 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cancer, Docetaxel, Sorafenib