Effectiveness of Gum Chewing on Ileus in Chinese Colorectal Patients Underwent Laparoscopic Colorectal Surgery

Study Overview
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Brief Summary
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Gum chewing group will have less ileus and early resume of bowel motion than control group.

Detailed Description
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The standardize surgical techniques, less used of epidural analgesia, early ambulation and used of naso-gastric tube for decompression are aimed to reduce the paralytic ileus after abdominal surgery . Most Western studies have examined and found that gum chewing are able to prevent postoperative ileus or promotes early bowel function after abdominal surgery.

Official Title
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Effectiveness of Gum Chewing on Reduction of Postoperative Paralytic Ileus for Chinese Colorectal Cancer Patients Underwent Laparoscopic Colorectal Surgery and Enhanced Recovery Program

Conditions
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Colorectal Cancer

Intervention / Treatment
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* Other: bubble gum


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with newly diagnosed colorectal cancer undergoing laparoscopic resection in in Queen Mary Hospital At least 18 years Speak Cantonese Able to follow study protocol and chewing gum study Exclusion Criteria: Cognitive disability Requirement of epidural analgesia Requirement of intensive care unit/ High dependency unit care postoperatively Inability to chew Presence of procedure other than colorectal resection Non Chinese

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: bubble gum chewing and routine care<br>Start chewing gum on postoperative day at three times daily with no more than 30 minutes till discharged | Other: bubble gum<br>* Chewing gum group patients performing gum chewing on postoperative day 1 at three times daily for 30 minutes after operation and until discharged.<br>|
| No Intervention: routine care<br>Non interventional group will receive existing routine care as usual | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time to first flatus | Time to passage of flatus after surgery was significantly shorter in the intervention group (22 vs 39 hours, p=0.007). | from postoperative day 0 till an expected average of day 7 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time to first sense of hunger | Patients in the intervention group also noticed feeling of hunger earlier (17 vs 40 hours, p<0.001). | from postoperative day 0 till an expected average of day 7 | 
| Time to first bowel movement, | The first bowel motion also occurred earlier in the intervention group (22 vs 52 hours, p<0.001) | from postoperative day 0 till an expected average of day 7 | 
| Length of stay | There is no difference in length of stay between intervention group or control group | from postoperative day 0 till an expected average of day 7 |