Systemic Inflammation During Recanalization of Cerebral Arterial Occlusion

Study Overview
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Brief Summary
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Strokes management, secondary to proximal arterial occlusion, by endovascular thrombectomy (TM) is now well established. The immuno-inflammatory events of reperfusion after TM are discussed. Systemic inflammation is a major factor suggested to explain the limited recovery of the ischemic parenchyma. Understanding these phenomena is necessary before developing an immunomodulatory strategy.

Official Title
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Systemic Inflammation During Recanalization of Cerebral Arterial Occlusion

Conditions
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Stroke, Systemic Infection

Intervention / Treatment
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* Biological: Blood sample


Participation Criteria
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Eligibility Criteria
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GROUP AVC : Inclusion Criteria: Adults patient (s) Ischemic stroke by occlusion of a middle cerebral artery (proximal portion M1) Initial diagnostic MRI infusion TM with complete reperfusion (TICI 2b, 2c or 3) TM performed under local anesthesia +/- anxiolysis, or sedation including propofol mRS prior to stroke <2 Barthel index <90 Included in the HIBISCUS cohort Patient who was informed and did not object to participating in the study OR included through the emergency procedure then collection of his non-objection or that of his trusted person as soon as possible Exclusion Criteria: NIHSS awareness score> or = 2 Haemorrhagic complication before thrombectomy Pregnant woman Multiple vascular occlusions Occlusions of posterior or anterior cerebral territories other than M1 Protected major TM performed under general anesthesia Other vital failure than neurological failure GROUP CONTROL : Inclusion Criteria: Adults patient (s) mRS <2 Barthel index <90 Requiring diagnostic arteriography for routine check-up of a cerebrovascular malformation Patient who was informed and did not object to participating in the study Exclusion Criteria: NIHSS awareness score> or = 2 Pregnant woman Protected major Exam performed under general anesthesia

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| AVC<br>Patients hospitalized for TM after a proximal ischemic stroke of the middle cerebral artery and whose reperfusion is satisfactory (TICI 2b, 2c and 3). Additional blood sample will be taken during usual treatment the day of the stroke. | Biological: Blood sample<br>* Patients from 2 groups will undergo blood sample (during a blood sample for there care) and inflammation parameters will be measure the day of the stroke<br>|
| Control<br>Population of control patients, consisting of patients admitted on an outpatient basis for a diagnostic cerebral arteriography. | Biological: Blood sample<br>* Patients from 2 groups will undergo blood sample (during a blood sample for there care) and inflammation parameters will be measure the day of the stroke<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Inflammation parameters description | Inflammatory parameters such as CRP, IL-6, IL-10, HLA-DR, TNF-alpha, polymorphonuclear chemotaxis, CD-4, T-lymphocytes will be measure in blood sample | 1 day |