Cone-beam CT Guided Microcoil Localization of Pulmonary Nodules During Video Assisted Thoracic Surgery(VATS)

Study Overview
=================
Brief Summary
-----------------
The Guided Therapeutics (GTx) program at the University Health Network is a network of clinicians, scientists, and engineers focused on the development and translation of image-guided technologies focused on minimally-invasive, adaptive therapies. Technologies developed within the GTx program include a portable intra-operative cone-beam CT (in collaboration with Siemens) that has been evaluated in clinical trials for head and neck surgery. The intraoperative imaging has been integrated with tracking and navigational tools and optical imaging to provide a general surgical dashboard that is used to improve the accuracy of surgical resection. A recent addition to the GTx program is the development of the GTx OR, located within the general operating room of the Toronto General Hospital. The GTx OR houses 2 complimentary advance technologies: the Siemens Zeego and the Siemens Somotom Flash CT. The dual-energy Somatom Flash provides a gold-standard in CT imaging, while the Zeego provides excellent 3D Cone-beam CT with robotic placement for flexible integration within the operating environment. Together, the integration of these 2 components into a single OR enables critical evaluation of the limits of CT imaging technology for surgical guidance. This study will be conducted using solely the Cone-beam CT (Zeego) for percutaneous placement and localization of markers for resection of small pulmonary nodules during VATS.

Official Title
-----------------
Cone-beam Computed Tomography (CT) Guided Microcoil Localization of Pulmonary Nodules During Video Assisted Thoracic Surgery(VATS)

Conditions
-----------------
Lung Cancer

Intervention / Treatment
-----------------
* Other: Cone Beam CT localization and placement of microcoil


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Any adult patient age 18 and older with lung nodules who are candidates for microcoil localization prior to VATS wedge resection Exclusion Criteria: Patients that are unable to give informed consent Patients that are unable to tolerate general anesthesia Patients who are pregnant or patients that believe they are pregnant Patients with implantable devices susceptible to Radio Frequency (RF) fields Severely obese patients

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Lung cancer<br> | Other: Cone Beam CT localization and placement of microcoil<br>* Cone Beam CT localization and placement of microcoil<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Radiation Exposure | Will determine how much radiation the patient receives via CT report | 4 years | 
| Length of time to perform procedure | Will time the procedure in order to determine procedure length | 4 years |