Standing Cognition and Co-morbidities of POTS Evaluation

Study Overview
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Brief Summary
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The purpose of this study is to evaluate cognition in patients with postural tachycardia syndrome (POTS) while lying down and standing and to assess the prevalence of hypermobile Ehlers-Danlos Syndrome in POTS.

Official Title
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Standing Cognition and Co-morbidities of POTS Evaluation

Conditions
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Postural Tachycardia Syndrome, Ehlers-Danlos Syndrome

Intervention / Treatment
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* Behavioral: Standing
* Behavioral: Supine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Previously diagnosed with POTS, or healthy control Age between 13-60 years Participants may be any race, ethnicity, sex, or gender Able and willing to provide informed consent Exclusion Criteria: Inability to give, or withdrawal of, informed consent Age ≤ 13 or ≥ 61 years Prisoners Unable to stand

Ages Eligible for Study
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Minimum Age: 13 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Standing<br>Participants will complete cognitive testing while standing. | Behavioral: Standing<br>* Participants will stand and complete cognitive tests.<br>|
| Active Comparator: Supine<br>Participants will complete cognitive testing while supine. | Behavioral: Supine<br>* Participants will complete cognitive tests while supine.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Executive Function (Stroop Word-color Test) | Testing scores are normalized using T-scores for predicted values based on age and education for each participant. Scores range from 0 to 100. Higher numbers indicate better cognition. Testing will be performed while participants are supine and standing. | 1 hour | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Attention Score Using Cogstate Identification Task | Scores are measured as speed to complete task with lower numbers indicating faster reaction time. Testing will be performed while participants are supine and standing. | 1 hour | 
| Number of Participants With Hypermobile Ehlers-Danlos Syndrome (hEDS) | hEDS was evaluated using the Diagnostic Criteria for hEDS checklist. The number of participants who fulfill the diagnostic criteria on the checklist are reported. | 1 hour | 
| Heart Rate Standing Minus Heart Rate Supine | Heart rate (HR) will be measured using an arm blood pressure cuff while participants are in supine and standing postures. The difference in heart rate (HR standing - HR supine) was calculated for each participant. | 1 hour | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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postural tachycardia syndrome, cognition