Expressive Writing in Male Infertility

Study Overview
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Brief Summary
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The purpose of this study is to determine whether expressive writing can be effective in improving the well-being and sperm quality in patients with male infertility.

Detailed Description
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Expressive writing is a therapeutic intervention designed by the psychologist James W. Pennebaker. Individuals write on three days for about 20 minutes about particularly stressful experiences in their life. Several studies showed that expressive writing can have beneficial effects on the frequency of health care utilization and well-being. Particularly in patients with rheumatism, kidney cancer and posttraumatic stress disorder expressive writing showed an positive effect on subjective well-being. Furthermore, in several studies expressive writing showed a positive effect on immune parameters. As many studies suggest an important negative effect of stress on well-being and sperm parameters in male infertility, we want to investigate the effect of expressive writing in male infertility.The expressive writing condition is compared to a non emotional writing condition, in which individuals write about mainly non emotional topics such as time management. In this randomized-controlled trial subjects were allocated sequentially by block wise randomization (block size of 4). For randomization a computer generated random list was used. The allocation was concealed in a series of numbered sealed envelopes. The envelope was opened immediately before the first writing session.

Official Title
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Expressive Writing as a Therapeutic Intervention in Male Infertility

Conditions
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Infertility, Male

Intervention / Treatment
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* Behavioral: Expressive writing


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Male infertile patients with a pathological spermiogram according to WHO criteria Exclusion Criteria: Drugs affecting sperm quality Patients with chromosomal anomalies affecting sperm quality (e.g. Klinefelter- Syndrome) Severe Psychiatric disorder defined as psychotic disorder (schizophrenia, bipolar disorder) or substance-related disorder Patients currently in psychotherapeutic or psychiatric therapy

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: A 1<br>Expressive writing | Behavioral: Expressive writing<br>* Patients in the intervention group write on three day for 20 minutes about highly emotional topics In the control group patients write on three days for 20 minutes about topics with relatively low emotional involvement such as diet, time management and sport.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Scores on rating scale for perceived stress in infertility |  | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Scores on rating scale for personality dimensions |  | 3 months | 
| Sperm parameters |  | 3-12 months | 
| Score on rating scale for coping |  | 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Expressive writing, Male infertility