Study of the Effects of Adolescent Weight Disorders (Obesity, Anorexia Nervosa) on Heart Function

Study Overview
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Brief Summary
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The study aims to better understand the functioning of the heart of children and adolescents with anorexia nervosa or obesity, compared to the heart function of control subject. This project seeks to find out if a weight disorder affects the heart and whether a systematic cardiac assessment with appropriate management is then to be considered. To meet this objective, several analyzes are planned including a speckle tracking echocardiography, allowing a non-invasive study of myocardial deformations. The hypothesis is that two opposite weight disorders (anorexia nervosa and obesity) lead to similar complications: inflammation, fibrosis altering the myocardial structure and therefore its contractility. Both systolic and diastolic dysfunction appear. Investigator hypothesize that the determinants of this dysfunction involve part of the alteration of body mass, and partly qualitative alterations specific to each pathology.

Detailed Description
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The main objective is to evaluate the cardiac dysfunctions through the study of myocardial deformities in anorexic and obese adolescents, in comparison with controls. The choice of a pediatric population is explained by the probable precocity of the cardiac repercussions of these weight disorders. The desire to bring together in the same study two opposite weight disorders is because a certain number of complications are common to both: repercussions on the cardiac mass, presence of chronic systemic inflammation, and fibrosis. Comparison to normo-weighted healthy subjects will make it possible to determine whether certain alterations are directly attributable to body composition (in the case of a continuum of a parameter between the three groups) or, on the contrary, independent of body composition. The search for the mechanisms at the origin of these alterations represents our secondary objective. For this, a correlation of the cardiac parameters with several factors such as: duration and severity of disorders, body composition, heart mass, presence of myocardial fibrosis, epicardial fat level, sympatho-vagal balance (by the cardiac variability), systemic inflammatory profile and potential pathways signaling involved (metabolomic analysis) will be carried out. All these parameters may impact cardiac function. Adolescent girls participating in the study will benefit from a clinical examination with fat / lean body mass measurement by impedance, assessment of heart rate variability, blood test (inflammation marker, metabolomic analysis) and ultrasound heart. Thus, screening for heart disease, and more generally complications of their pathology, will be performed. This project is important to answer the question of the necessity or not of a systematic cardiac assessment in these adolescents and the setting up of an adapted care

Official Title
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Study of the Effects of Adolescent Weight Disorders (Obesity, Anorexia Nervosa) on Heart Function

Conditions
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Anorexia Nervosa, Obesity

Intervention / Treatment
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* Behavioral: echocardiography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: girls between 12 and 18, affiliated to a social security with behavioral eating disorder characterized by a drastic reduction in intakes resulting in weight loss and a BMI ≤ 17.5 kg / m2. Anorexia can be restrictive pure or associated with bulimia or, with a BMI projecting ≥ 30 kg / m2 at the age of 18 (IOTF C30) or, without BMI abnormality, without eating disorders, without serious medical pathology Exclusion Criteria: for anorexics, uncorrected nutritional deficiency for the obese, secondary obesity for all, inability to provide informed consent, pregnancy or breastfeeding, heart disease, high blood pressure, sleep apnea syndrome, dyslipidemia, diabetes, chronic pathology including inflammatory.

Ages Eligible for Study
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Minimum Age: 12 Years
Maximum Age: 18 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| anorexia nervosa<br>girls between 12 and 18 years old with behavioral eating disorder characterized by a drastic reduction in intakes resulting in weight loss and a BMI ≤ 17.5 kg / m2. Anorexia can be restrictive pure or associated with bulimia | Behavioral: echocardiography<br>* speckle tracking echocardiography evaluation of cardiac variability by recording heart rate as several hours (POLAR watch) bioimpedance blood test for biological assays (metabolomic analysis)<br>|
| obesity<br>girls between 12 and 18 years old with a BMI projecting ≥ 30 kg / m2 at the age of 18 (IOTF C30). | Behavioral: echocardiography<br>* speckle tracking echocardiography evaluation of cardiac variability by recording heart rate as several hours (POLAR watch) bioimpedance blood test for biological assays (metabolomic analysis)<br>|
| normal weight<br>girls between 12 and 18 years old without BMI abnormality, without eating disorders, without serious medical pathology | Behavioral: echocardiography<br>* speckle tracking echocardiography evaluation of cardiac variability by recording heart rate as several hours (POLAR watch) bioimpedance blood test for biological assays (metabolomic analysis)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| systolic global longitudinal strain | echocardiographic parameter of myocardial deformation: index of myocardial systolic function in percent | at inclusion | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| heart rate variability | holter measurement of standard deviation of all intervals between heart beat(SDNN) in ms | at inclusion during first night | 
| body composition | fat mass and lean mass in percent | at inclusion | 
| cardiac blood markers | blood sampling: N-Terminal-proBNP in ng/L | at inclusion | 
| inflammation blood markers | blood sampling: CRP in mg/L | at inclusion | 
| hormonal blood markers | blood sampling: oestradiol in pg/ml | at inclusion | 
| blood hemoglobin | blood sampling: in g/L | at inclusion | 
| ionogram blood markers | blood sampling: blood potassium in mmol/l | at inclusion | 
| heart rhythm and conduction | electrocardiogram to determine ECG QT Interval | at inclusion | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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cardiac function, adolescent, obesity, speckle tracking echocardiography, anorexia nervosa, metabolomic