Emotional Dysregulation in Adult ADHD.

Study Overview
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Brief Summary
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Attention deficit disorder in adults with or without hyperactivity (ADHD) is a common disorder, affecting around 3% of the population. ADHD increases the risk of psychiatric disorders (mood disorders, sleep disorders, personality disorders, addictive behavior), risky behaviors, and vocational difficulties. Emotional dysregulation (ED) constitute a major hindrance in the daily life of subjects, with a great impact on the general functioning and the quality of life of the patients. The investigators want to determine the characteristics of patients with each type of ED (impulsivity, exacerbated emotional intensity, cyclothymia, borderline personality traits), and study the stability of these traits over time. Since circadian rhythms influence mood and circadian rhythms frequently occur in patients with ADHD, the investigators want to determine if there is a link between ED and instability in circadian rhythms. Finally, they would like to observe whether the ED evolves and according to whether or not treatment is taken

Official Title
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Emotional Dysregulation and Cyclothymia in Adult Patients With ADHD: Cohort Follow-up of Patients in Two Referral Centers

Conditions
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Adult ADHD

Intervention / Treatment
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* Other: Neuropsychological testing
* Other: Actimetry
* Other: Self-questionnaires on emotional topics


Participation Criteria
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Eligibility Criteria
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Inclusion criteria: Male or female aged ≥ 18 years diagnosis of adult ADHD prior to inclusion Affiliated to a social health insurance Subject having dated and signed informed consent Subject having been informed of the results of the prior medical examination Exclusion criteria: Mobility project preventing follow-up for 1 year (planned move) impossibility to give the subject information enlightened (subject in emergency situation, difficulties in understanding the subject, mental retardation, illiteracy or insufficient command of the French language ...) Subject under the protection of justice Subject under guardianship or curatorship Pregnancy Breastfeeding

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Cohort group<br>All participants will have evaluations at inclusion and 12 months. Neuropsychological testing Actimetry Selfquestionnaires on emotional topics | Other: Neuropsychological testing<br>* The assessment will will be done at the time of the initial evaluation (undiagnosed / untreated patients), then at one year of follow-up<br>* Other names: executive functions;Other: Actimetry<br>* The assessment will will be done at the time of the initial evaluation (undiagnosed / untreated patients), then at one year of follow-up.<br>* Other names: Selfquestionnaires on emotional topics;Other: Self-questionnaires on emotional topics<br>* The assessment will will be done at the time of the initial evaluation (undiagnosed / untreated patients), then at one year of follow-up.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Characterization of emotional dysregulation (descriptive analysis of different scales assessing emotional dysregulation) | Score of cyclothymia (TEMPS-A scale) | At inclusion | 
| Characterization of emotional dysregulation (descriptive analysis of different scales assessing emotional dysregulation) | Score of cyclothymia (TEMPS-A scale) | At 12 months after inclusion | 
| Characterization of emotional dysregulation (descriptive analysis of different scales assessing emotional dysregulation) | Score of emotional lability (ALS scale) | At inclusion | 
| Characterization of emotional dysregulation (descriptive analysis of different scales assessing emotional dysregulation) | Score of emotional lability (ALS scale) | At 12 months after inclusion | 
| Characterization of emotional dysregulation (descriptive analysis of different scales assessing emotional dysregulation) | Score of emotional dysregulation (WRAADDS scale) | At inclusion | 
| Characterization of emotional dysregulation (descriptive analysis of different scales assessing emotional dysregulation) | Score of emotional dysregulation (WRAADDS scale) | At 12 months after inclusion | 
| Characterization of emotional dysregulation (descriptive analysis of different scales assessing emotional dysregulation) | Score of borderline personality symptoms (BSL scale) | At inclusion | 
| Characterization of emotional dysregulation (descriptive analysis of different scales assessing emotional dysregulation) | Score of borderline personality symptoms (BSL scale) | At 12 months after inclusion | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Association between emotional dysregulation, cognitive deficits and circadian instability | Correlation between emotional dysregulation and executive and attentional dysfunction measured with the TAP test. Correlation between emotional dysregulation and instability index of circadian rhythms measured by actimetry. | At inclusion | 
| Association between emotional dysregulation, cognitive deficits and circadian instability | Correlation between emotional dysregulation and executive and attentional dysfunction measured with the TAP test. Correlation between emotional dysregulation and instability index of circadian rhythms measured by actimetry. | At 12 months after inclusion | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Actimetry, Cohort study, Emotion dysregulation, Questionnaires, Neuropsychology