Low Tube Voltage Computed Tomographic (CT) Urography Using Low Concentration Iodine Contrast Agent

Study Overview
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Brief Summary
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Computed Tomographic (CT) urography is the best imaging modality to evaluate obstructing lesions of urinary tract such as urinary stone, tumor and inflammatory lesion. The purpose of our study is to compare images of CT urography performed by low voltage and low concentrated iodine CT contrast with them of conventional CT urography.

Detailed Description
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Computed Tomographic (CT) urography is the best imaging modality to evaluate obstructing lesions of urinary tract such as urinary stone, tumor and inflammatory lesion. It is needed that CT urography should have the high contrast between target lesion described as filling defect and adjacent contrast filled urinary tract. For the implementation of high contras, conventional CT urography has been performed with higher voltage and higher concentrated CT contrast than another CT protocols. The higher voltage results in the more radiation exposure. And the intravenous injection of higher concentrated CT contrast results in the increase of the prevalence of contrast induced nephrotoxicity. The purpose of our study is to compare images of CT urography performed by low voltage and low concentrated iodine CT contrast with them of conventional CT urography.

Official Title
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Low Tube Voltage Computed Tomographic (CT) Urography Using Low Concentration Iodine Contrast Agent: a Comparison Study With Conventional CT Urography

Conditions
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Exposure to Medical Diagnostic Radiation

Intervention / Treatment
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* Radiation: Computed tomographic urography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients to perform Computed Tomographic (CT) urography Patients without diminish of renal function (serum creatinine: more than 1.4 mg/dl & glomerular filtration rate: more than 34 mL/min/1.73 m2) Exclusion Criteria: patients to have operations and/or injuries of urinary system patients to have the histories of anaphylaxis or allergic reaction about intravenous iodine contrast material

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Conventional<br>Computed tomographic urography was done with conventional protocols. | Radiation: Computed tomographic urography<br>* Computed tomographic (CT) urography was done with the protocols of low voltage and low iodine concentration.<br>|
| Experimental: Reduced<br>Computed tomographic urography was done with the protocols of low voltage and low iodine concentration. | Radiation: Computed tomographic urography<br>* Computed tomographic (CT) urography was done with the protocols of low voltage and low iodine concentration.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measurement of Radiation Dose |  | The day of admission (within 24hours) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Computed Tomography, Spiral, Urography, Radiation dosage, Contrast media