Respiratory Care in Intensive Care Unit for Neuromuscular Patients

Study Overview
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Brief Summary
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Retrospective multicentric observational study exploring the population of adult neuromuscular patients presenting a respiratory distress requiring their admission in an Intensive Care Unit (ICU) for ventilatory support. Research of markers associated with long term mortality and ventilatory status.

Official Title
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Modalities of Respiratory Care, Vital and Respiratory Prognosis in Neuromuscular Patients Admitted to an Intensive Care Unit for Respiratory Failure

Conditions
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Respiratory Failure

Intervention / Treatment
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* Other: Ventilatory support


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient > 18 years old First stay in a ICU ward Inclusion period : Admission in ICU between 01/01/2007 and 31/12/2015 Presenting an acute respiratory distress at admission or during ICU stay Diagnosis of neuromuscular disease confirmed before Hospital discharge Exclusion Criteria: Absence of respiratory failure during ICU stay (ICU stay for monitoring or for a specialized invasive procedure in the absence of respiratory failure, for example) Neuromuscular disease not proven or uncertain diagnosis Anterior admission in ICU ward for vital organ failure

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Ventilatory support<br>Adult patients presenting a neuromuscular disease, with involvement of respiratory or bulbar muscles | Other: Ventilatory support<br>* Initiation of mechanical ventilatory support, invasive or non-invasive, Or modification of mechanical ventilatory support (modification of the parameters of the device, change of material, switch from non-invasive to invasive)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality | number of death | until 2016.12.31 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Definitive long term invasive ventilatory support | Date of tracheotomy for definitive long term invasive ventilatory support | until 2016.12.31 | 
| Mortality attributable to a respiratory issue | For patients for which this information is available, cause of death described as reliable to a respiratory issue in any medical document available. | until 2016.12.31 | 
| Re-hospitalization in a ICU-Ward | clinical deterioration requiring a new hospitalization in a ICU ward, after first hospitalization discharge. | until 2016.12.31 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Neuromuscular Diseases, Muscular dystrophy, Amyotrophic Lateral Sclerosis, Acute respiratory failure, respiratory care, mechanical ventilation, weaning, Intensive Care Unit, Critical Care, Survival