Development of Clinical Assessment Technique Using Multi-radiotracer PET/MR in Prostate Cancer

Study Overview
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Brief Summary
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To development of clinical assessment technique using multi-radiotracer positron emission tomography/magnetic resonance (PET/MR) in prostate cancer to establish the optimal imaging technique of PET/MR using multiple radioactive tracers for prostate cancer to establish the imaging biomarker using PET/MR for clinical assessment of prostate cancer and early detection of recurrent prostate cancer

Detailed Description
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To establish the optimal imaging technique of PET/MR using multiple radioactive tracers for prostate cancer Recruiting 30 patients with prostate cancer ahead to radical prostatectomy PET/MR using 18F-choline with dedicated prostate MRI in all patients PET/MR using 18fluoride(F)-fluorodeoxyglucose(FDG)in all patients after 2-7 days PET/CT using 18F-FDG in all patient immediate after 18F-FDG PET/MR outcome assessment: comparison of scan time, image quality, tumor detection rate, standardized uptake values of lesions establishing optimal imaging technique for prostate PET/MR To establish the imaging biomarker using PET/MR for clinical assessment of prostate cancer comparison of findings on PET/MR, MRI and PET/CT with pathological mapping after radical prostatectomy outcome assessment: accuracy of PET/MR for localization and staging of prostate cancer compared with MRI only and PET/CT only To establish the imaging biomarker using PET/MR for early detection of recurrent prostate cancer Recruiting 15 patients with recurrent prostate cancer treated by surgery, hormone, or radiation therapy Recruiting 15 patients with treated prostate cancer without recurrence PET/MR using 18F-choline with dedicated prostate MRI in all patients PET/MR using 18F-FDG in all patients after 2-7 days PET/CT using 18F-FDG in all patient immediate after 18F-FDG PET/MR comparison of findings on PET/MR, MRI, and PET/CT with clinical data in two patient groups with or without recurrent prostate cancer outcome assessment: accuracy of PET/MR for early detection and localization of recurrent prostate cancer compared with MRI only and PET/CT only

Official Title
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Development of Clinical Assessment Technique Using Multi-radiotracer PET/MR in Prostate Cancer

Conditions
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Prostate Cancer Recurrent, Stage II Prostate Carcinoma, Stage III Prostate Carcinoma

Intervention / Treatment
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* Device: PET/MR


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patient with prostate cancer before treatment patient with prostate cancer treated patient with prostate cancer recurrent Exclusion Criteria: patient with contraindication for MRI Patient with severe renal impairment
Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: PET/MR<br>Multi-radiotracer PET/MR will be performed to compare the accuracy of tumor detection in patient with primary prostate cancer | Device: PET/MR<br>* Multi-radiotracer PET/MR will be performed in patients with primary and recurrent prostate cancer<br>* Other names: Biograph mMR, Siemens Healthcare;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| accuracy of PET/MR predicting localization and staging of prostate cancer | analysis of accuracy of PET/MR predicting localization and staging of prostate cancer by comparison of PET/MR findings with pathological mapping images after radical prostatectomy | 1 week after radical prostatectomy | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| accuracy of early detection and localization of recurrent prostate cancer | accuracy of PET/MR for early detection and localization of recurrence by comparison of PET/MR findings with clinical data in two groups of patients with or without recurrent prostate cancer | 1 week after PET/MR imaging | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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prostate cancer, MRI, PET