The Difference in Duration of Sciatic Nerve Block Between Diabetic and Non-diabetic Patients

Study Overview
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Brief Summary
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This study aims to compare the sensory and motor block duration and the incidence of nerve injury after sciatic nerve block between diabetic and non-diabetic patients, and screen for the factors that may affect the block recovery.

Detailed Description
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This is an observational study. All participants who experienced unilateral lower limb surgery and received an ultrasound-guided (nerve stimulator assisted) subgluteal sciatic nerve block with 0.75% ropivacaine 20ml in Peking Union Medical College Hospital were selected. They were further assigned to either diabetic group or non-diabetic group according to their medical history (primary exposure). The primary end point was the sensory and motor block duration. These durations in terms of sensory and motor blocks of sciatic nerve(dorsal side, plantar side) were assessed at baseline, every 2 hours in 48 hours after the block (except for the second night). In addition, the associations between fasting blood glucose, glycosylated hemoglobin (hemoglobin A1c, HbA1c) and the degree of diabetic retinopathy and the durations of sensory and motor block were also examined. This is not a intervention study, because we will examine the outcomes between diabetic or non-diabetic patients.

Official Title
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The Difference in Duration of Sciatic Nerve Block Between Diabetic and Non-diabetic Patients

Conditions
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Sciatic Nerve Block

Intervention / Treatment
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* Procedure: Subgluteal sciatic nerve block


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: American Society of Anesthesiologists :I-III; Age>=18 years; Undergo unilateral lower limb surgery; Sign consent form. Exclusion Criteria: Refuse regional Anesthesia; Thresh of sensory >10g; Dyskinesia; Bleeding disorder; Regional skin infection; Regional drug allergy; Renal disfunction; Incompliant to study; Drug abuse.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Diabetes<br>Diabatic participants who experienced unilateral lower limb surgery and received an ultrasound-guided (nerve stimulator assisted) subgluteal sciatic nerve block with 0.75% ropivacaine 20ml in Peking Union Medical College Hospital were selected. | Procedure: Subgluteal sciatic nerve block<br>* All patients (either diabetic or non-diabetic patients) received an ultrasound-guided (nerve stimulator assisted) subgluteal sciatic nerve block with 0.75% ropivacaine 20ml.<br>|
| non-Diabetes<br>Non-diabatic participants who experienced unilateral lower limb surgery and received an ultrasound-guided (nerve stimulator assisted) subgluteal sciatic nerve block with 0.75% ropivacaine 20ml in Peking Union Medical College Hospital were selected. | Procedure: Subgluteal sciatic nerve block<br>* All patients (either diabetic or non-diabetic patients) received an ultrasound-guided (nerve stimulator assisted) subgluteal sciatic nerve block with 0.75% ropivacaine 20ml.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Duration of sensory block | Sensory block is measured by Semmes Weinstein monofilaments. The block is measured at baseline, and every 2hours in 48 hours after the block. | 48 hours | 
| Duration of motor block | Motor blocks is visualized. The block is measured at baseline, and every 2hours in 48 hours after the block | 48 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Sciatic nerve block, block duration, Semmes Weinstein monofilaments, fasting blood glucose, nerve block, sensory block duration, motor block duration