Metacognition in Semantic Dementia: Comparison With Alzheimer's Disease

Study Overview
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Brief Summary
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This study aims at exploring patients' ability to monitor their own memory performance depending on their primary deficit and the type of memory involved in the criterion task. The goal is to evaluate if semantic dementia (SD) and Alzheimer's disease (AD) differently affect patients' awareness of their memory abilities.

Detailed Description
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Patients who will give their informed non-opposition will be included. Participants will undergo 6 metacognitive tasks in which they will be tested on newly learnt information (i.e., episodic memory) or prior knowledge (i.e., semantic memory) and asked to evaluate their performance either prior or after the test. Correlation between their evaluation and their actual performance will be measured. Performance and correlations will be compared across groups.

Official Title
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Metacognition in Semantic Dementia: Comparison With Alzheimer's Disease

Conditions
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Semantic Dementia, Alzheimer Disease, Healthy

Intervention / Treatment
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* Other: Metacognition tests


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: native French-speakers normal or corrected-to-normal vision for patients ONLY : doctor-approved diagnosis of semantic dementia or Alzheimer's disease for healthy participants ONLY: score above 27 on the MMSE non-opposition in participation Exclusion Criteria: other neurological/ psychiatric disorder, or cognitive disorder that might affect general cognition drug or alcohol abuse
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Semantic dementia<br>Diagnosis of semantic dementia (revised criteria Moreaud et al., 2008; based on Neary et al., 1998) | Other: Metacognition tests<br>* Test on episodic or semantic memory<br>|
| Alzheimer's disease<br>NIAAA 2011 criteria | Other: Metacognition tests<br>* Test on episodic or semantic memory<br>|
| Control<br>MMSE above 27, no neurological or psychiatric disorder | Other: Metacognition tests<br>* Test on episodic or semantic memory<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Metacognitive bias on the episodic predictive judgment task | Metacognitive bias will be assessed by subtracting the mean proportion of the metacognitive judgments to the actual memory performance. Bias will range from -1 (underestimation) to 1 (overestimation). | End of study : around May 2022 | 
| Metacognitive accuracy on the episodic predictive judgment task | Metacognitive accuracy will be assessed by calculating a gamma correlation for each participant. Metacognition accuracy allows to evaluate people's ability to discriminate correct responses from incorrect responses. Gamma correlation range from -1 to 1. | End of study : around May 2022 | 
| Metacognitive bias on the semantic predictive judgment task | Metacognitive bias will be assessed by subtracting the mean proportion of the metacognitive judgments to the actual memory performance. Bias will range from -1 (underestimation) to 1 (overestimation). | End of study : around May 2022 | 
| Metacognitive accuracy on the semantic predictive judgment task | Metacognitive accuracy will be assessed by calculating a gamma correlation for each participant. Metacognition accuracy allows to evaluate people's ability to discriminate correct responses from incorrect responses. Gamma correlation range from -1 to 1. | End of study : around May 2022 | 
| Metacognitive bias on episodic global judgment task | Metacognitive bias will be assessed by subtracting the mean proportion of the metacognitive judgments to the actual memory performance. Bias will range from -1 (underestimation) to 1 (overestimation). | End of study : around May 2022 | 
| Metacognitive bias on semantic global judgment task | Metacognitive bias will be assessed by subtracting the mean proportion of the metacognitive judgments to the actual memory performance. Bias will range from -1 (underestimation) to 1 (overestimation). | End of study : around May 2022 | 
| Metacognitive bias on the episodic retrospective judgment task | Metacognitive bias will be assessed by subtracting the mean proportion of the metacognitive judgments to the actual memory performance. Bias will range from -1 (underestimation) to 1 (overestimation). | End of study : around May 2022 | 
| Metacognitive accuracy on the episodic retrospective judgment task | Metacognitive accuracy will be assessed by calculating a gamma correlation for each participant. Metacognition accuracy allows to evaluate people's ability to discriminate correct responses from incorrect responses. Gamma correlation range from -1 to 1. | End of study : around May 2022 | 
| Metacognitive bias on the semantic retrospective judgment task | Metacognitive bias will be assessed by subtracting the mean proportion of the metacognitive judgments to the actual memory performance. Bias will range from -1 (underestimation) to 1 (overestimation). | End of study : around May 2022 | 
| Metacognitive accuracy on the semantic retrospective judgment task | Metacognitive accuracy will be assessed by calculating a gamma correlation for each participant. Metacognition accuracy allows to evaluate people's ability to discriminate correct responses from incorrect responses. Gamma correlation range from -1 to 1. | End of study : around May 2022 |