A Study on the Prevalence of Obstructive Sleep Apnea in Patients With Type II Diabetes Mellitus

Study Overview
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Brief Summary
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OSA is prevalent among patients with type II DM

Detailed Description
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Obstructive sleep apnea (OSA) has been reported to be common (prevalence ranged from 23-86%) in previous studies involving Caucasian diabetic patients. The investigators aim at finding out the prevalence of OSA in Chinese diabetic patients and identify the clinical predictors associated with OSA. Recruited subjects will undergo overnight polysomnography, anthropometric measurements, blood tests including glycosylated hemoglobin, renal function, glucose level, blood pressure measurement both during the clinic visit and after admission for in-laboratory sleep study.

Official Title
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Prevalence and Recognition of Obstructive Sleep Apnea in Chinese With Type 2 Diabetes Mellitus

Conditions
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Obstructive Sleep Apnea, Diabetes Mellitus

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients, age 18 - 75, with type 2 diabetes mellitus, including those on diet, on oral-hypoglycaemic agents or on insulin Patients who are able to give written consent to undergo polysomnography Exclusion Criteria: Patients who are unable or unwilling to give written consent to participate in the study Patients with unstable medical illness or poor functional performance Patients with recent myocardial infarction or hospital admission for congestive heart failure or cardiac arrhythmia in the past three months Patients on renal replacement therapy for diabetic nephropathy or chronic renal failure, or plan to start renal replacement therapy in the coming six months Patients suffered from recent stroke in the past six months or previous history of stroke with significant focal neurological deficit Patients with type I diabetes Pregnant lady or lactating women

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| presence of OSA | The diagnosis of OSA will be confirmed with polysomnography | measured at a single time point during the recruitment period(2007-08), by polysomnography | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| severity of OSA | The severity of OSA will be assessed in terms of apnea hypopnea index, minimal oxygen saturation, duration of desaturation, arousal index during polysomnography | measured at a single time point during the recruitment period(2007-08), by polysomnography | 
| glycemic control | by measuring glycosylated hemoglobin, blood glucose level | measured at a single time point, when the subjects were admitted for polysomnography (during 2007-08) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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obstructive sleep apnea, prevalence, diabetes mellitus, Chinese