Effect of the Addition of Dexmedetomidine to Bupivacaine During Supraclavicular Brachial Plexus Blockade

Study Overview
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Brief Summary
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the aim of this study was effect of the addition of dexmedetomidine to bupivacaine during supraclavicular brachial plexus blockade for forearm surgery, by low doses bupivacaine providing prolonged analgesia after surgery.

Detailed Description
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Anaesthesia for surgeries to the upper extremity commonly is provided using brachial plexus anaesthesia.Various local anaesthetic mixtures can be used to prolong local anaesthesia duration and epinephrine , opioids and dexmedetomidine are frequently used for this purpose. this study was conducted to compare the effects of adding dexmedetomidine to local anaesthetics in the supraclavicular brachial plexus block by using nerve stimulators and ultrasonography guided. dexmedetomidine has also been found the prolong the duration of bupivacaine infraclavicular brachial plexus block.

Official Title
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Effect of the Addition of Dexmedetomidine to Bupivacaine During Supraclavicular Brachial Plexus Blockade for Forearm Surgery.

Conditions
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Sequelae of Fracture of Forearm and Upper Arm

Intervention / Treatment
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* Drug: dexmedetomidine
* Drug: bupivacaine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 18-65 age unwanted general anaesthesia ASA 1-2 single forearm, arm surgery Exclusion Criteria: major psychiatric problems major neurologic deficits coagulopathy drug allergies chronic analgesic used

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: dexmedetomidine and bupivacaine<br>Bupivacaine 50 mg and dexmedetomidine 1 microgram/kg | Drug: dexmedetomidine<br>* 1 ml 100 mcg dexmedetomidine+ 15 ml 0.25 % bupivacaine are applied around brachial plexus<br>* Other names: precedex;Drug: bupivacaine<br>* 30 ml 0.25 % bupivacaine is applied around brachial plexus<br>* Other names: marcaine;|
| Experimental: Bupivacaine and placebo<br>Bupivacaine 100 mg and SF 10 ml | Drug: dexmedetomidine<br>* 1 ml 100 mcg dexmedetomidine+ 15 ml 0.25 % bupivacaine are applied around brachial plexus<br>* Other names: precedex;Drug: bupivacaine<br>* 30 ml 0.25 % bupivacaine is applied around brachial plexus<br>* Other names: marcaine;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the duration of sensorial block | pin-prick test | postoperative 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the first time analgesic required |  | postoperative 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Supraclavicular block