linjc16/ctgov huggingface dataset:
SWiss Evaluation of Bioabsorbable Polymer-coated Everolimus-eluting Coronary sTent

Study Overview
=================
Brief Summary
-----------------
Bioresorbable polymer drug eluting stents (DES) are an indisputable improvement over first-generation DES with promising results on long-term adverse events. But the thicker polymer and/or strut may hinder its deliverability. Complex procedures challenge stent deliverability and stent delivery failure impacts clinical prognosis. This registry aimed to assess the immediate performance of the third-generation Synergy everolimus-eluting stent (sEES) and its 12-month clinical follow-up in an all-comer population.

Detailed Description
-----------------
All consecutive patients treated with the SYNERGY stent at our institutions were prospectively included in the SWEET registry. Baseline and procedural characteristics were collected at index procedure. Clinical follow-up was performed at 1 month and 1 year by clinic visit or follow-up call. The study end point was a composite of cardiac death (CD), myocardial infarction (MI) and target lesion revascularization (TLR) at 1 year.

Official Title
-----------------
SWiss Evaluation of Bioabsorbable Polymer-coated Everolimus-eluting Coronary sTent The SWEET Registry

Conditions
-----------------
Coronary Artery Disease

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 1.Patient treated by everolimus-eluting SYNERGY® stent Exclusion Criteria: 1. Patient or legal guardian won't give consent to use collected data

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| MACE | 12-month device-oriented MACE (dMACE) as defined by ARC (cardiac death, MI and TLR). | at 12 month follow up | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
DES, SDF, MACE, SYNERGY
Chemotherapy With DNA Damaging Agents In Colorectal Cancer

Study Overview
=================
Brief Summary
-----------------
Chemotherapy Treatment alone with DNA damaging drugs might be as effective as chemotherapy combined with surgery in colorectal cancer (CRC) avoiding surgery complications.

Official Title
-----------------
Phase 1 Study Of The Efficacy Of Chemotherapy With DNA Damaging Agents Versus Surgery In Colorectal Cancer

Conditions
-----------------
Colorectal Cancer

Intervention / Treatment
-----------------
* Other: Treatment with chemotherapy
* Other: Only chemotherapy treatment for study cohort
* Procedure: surgery


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: - patients that did not underwent surgery Exclusion Criteria: - patients that underwent surgery

Ages Eligible for Study
-----------------
Minimum Age: 40 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Control (chemotherapy and surgery)<br>Patients treated with chemotherapy + surgery | Other: Treatment with chemotherapy<br> <br> Procedure: surgery<br> <br> |
| Active Comparator: Study<br>Patients treated only with chemotherapy | Other: Only chemotherapy treatment for study cohort<br>* Control patients were treated both with surgery and chemotherapy. Study patients were treated only with chemotherapy<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
DNA damaging agents
The Effects of Puberty and Weight on Sugar Metabolism in Children

Study Overview
=================
Brief Summary
-----------------
Our goal is to investigate how hormones that control blood sugar, hunger, and stomach emptying change with puberty and being overweight. These substances change with a meal. For this, we need to compare lean and overweight children. We need to study them before and during puberty. All children in the study will be tested before and after a liquid meal.

Official Title
-----------------
The Role of Puberty and Insulin Resistance in the Development of Hyperglucagonemia

Conditions
-----------------
Overweight, Leanness, Adolescent

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All groups: Healthy lean and otherwise healthy overweight children and adolescents between the ages of 8 and 17. Exclusion Criteria: Same for all groups The subjects will be excluded if they have: a history of chronic disease allergy to acetaminophen evidence or history of chemical abuse abnormal lab values pregnancy

Ages Eligible for Study
-----------------
Minimum Age: 8 Years
Maximum Age: 17 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group A<br>Healthy lean children before puberty | |
| Group B<br>Otherwise healthy overweight children before puberty | |
| Group C<br>Healthy lean adolescents in mid to late puberty | |
| Group D<br>Otherwise healthy overweight adolescents in mid to late puberty | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overweight and Lean Children Sugar Metabolism Before and During Puberty | Too much weight gain can cause changes in the substances that control blood sugar and hunger in the body. Scientists need to compare these substances in lean and overweight children before and during puberty. These substances can be measured before and after a meal in the blood and in the urine. The way your stomach moves food can change your sugar levels. We want to understand how diabetes develops by studying these things. This can help find better ways to prevent and treat diabetes. | 4 hours | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Obese, Lean, Pubertal, Prepubertal, Glucose, Adolescents, Type 2 Diabetes
Experiences of Pregnant Women Who Use NRT in Pregnancy as Part of a Quit Attempt

Study Overview
=================
Brief Summary
-----------------
This study is largely a qualitative study with a small survey component. The aim of the survey would be to gain a quantitative perspective of how women use NRT after this has been prescribed by stop smoking services (SSS). The aim of the qualitative study would be to enhance knowledge of pregnant smoker's views and attitudes about their experiences of using NRT and in particular to understand why pregnant women who start using NRT often discontinue this early or do not use the medication as it is prescribed. This information is important for a number of reasons; firstly it will help health professionals and researchers gain an in depth understanding about how women experience using NRT, which may be used to help devise strategies for encouraging better adherence and which could be used in future clinical trials to gain a clearer understanding as to whether or not NRT is effective in pregnancy.

Official Title
-----------------
Experiences of Pregnant Women Who Use NRT in Pregnancy as Part of a Quit Attempt

Conditions
-----------------
Qualitative, Nicotine Replacement Therapy, Pregnancy

Intervention / Treatment
-----------------
* Other: Qualitative and survey


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Quantitative survey; Women who are pregnant Aged 16 or over (no upper age limit) Who have been prescribed NRT (patches/dual therapy) to aid a quit attempt. Qualitative interview study will include the above plus; Women will have used NRT for over 24 hours Either not be using NRT as prescribed (as deciphered by the survey questions) or have currently quit NRT (and have either stopped smoking or continue to smoke) Exclusion Criteria: Survey and qualitative interviews Women who cannot understand the study procedure sufficiently in order to provide consent e.g. due to cognitive difficulties Women who are unable to read or understand the consent procedure and study procedures in English.

Ages Eligible for Study
-----------------
Minimum Age: 16 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Nicotine Replacement Therapy<br> | Other: Qualitative and survey<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| number of women that use NRT after being prescribed | All women will be asked whether they have used NRT after being given a prescription, this measurement will be obtained within 4 weeks of the participant consenting to take part in the study. | within 4 weeks of taking part in the study | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of women who adhere to NRT |  | 4 weeks |
Novel Medications for Opiate Detoxification - 4

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate novel medications for opiate detoxification.

Official Title
-----------------
Novel Medications for Opiate Detoxification

Conditions
-----------------
Opioid-Related Disorders, Substance-Related Disorders

Intervention / Treatment
-----------------
* Drug: Clonidine


Participation Criteria
=================
Eligibility Criteria
-----------------
Please contact site for information.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Clonidine|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Withdrawal severity |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Opioid-Related Disorders
Pulse Waves and Tongue Diagnosis Differences Between Follicular and Luteal Phase in Normal Healthy Women

Study Overview
=================
Brief Summary
-----------------
We hypothesized that there's difference between follicular phase and luteal phase of normal women in radial pulse waves and tongue figures.

Detailed Description
-----------------
As comparing with follicular and menstrual phases of the cycle, in women during the luteal phase, the heart rate, body temperature, foot skin temperature and body weight were significantly increased. Tongue inspection and pulse examination are two methods that Chinese medical doctors are used in the diagnosis of patterns. Pulse wave analysis of the radial artery is a non-invasive, widely applicable technique for assessing cardiovascular function. Radial artery waveforms have been demonstrated being associated with the blood pressure wave of ascending and central aorta, the function of left ventricle , the arterial wall properties and the endothelial function. Even when measure locally, carries characteristic information from the whole arterial system because of reflection of waves at distinct sites of the arterial system. Examination of the changes of the arterial pulse wave between follicular phase may offer valuable insights into cardiovascular physiologic feature in menstrual cycle. The objective of this study was to test the hypothesis that the cyclic variations in hemodynamic and volume parameters during the menstrual cycle among normal healthy women. To that end we compared the following parameter of radial pulse contour between late follicular and late luteal time point: percussion wave, the difference between dicrotic wave and dicrotic notch, and the area of the wave.

Conditions
-----------------
Healthy

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Nornal period I/D=28-35/3-5 (eumenorrheic) age:21-40 No use of oral pills in past 6 months BMI1: 8.5-24.9 No history of smoke, alcohol or drug abuse No regular exercise in past 3 month Exclusion Criteria: CVD, hepatic, renal disease psychological disease Thyroid disease

Ages Eligible for Study
-----------------
Minimum Age: 21 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
normal healthy women
Feasibility Testing of a Novel Endoscope for Reflectance Confocal Microscopy of Normal Oral Tissue In Vivo

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to obtain images (pictures) of normal oral tissue, which occur inside the mouth, using a special camera. These pictures will be used in our research to evaluate a new technology that uses a laser and takes pictures of the microscopic structure of tissue. The technology is called reflectance confocal microscopy.

Official Title
-----------------
Feasibility Testing of a Novel Endoscope for Reflectance Confocal Microscopy of Normal Oral Tissue In Vivo

Conditions
-----------------
Oral Tissue

Intervention / Treatment
-----------------
* Device: Reflectance Confocal Microscopy (RCM) endoscope device


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy volunteers Ability to sign informed consent Age ≥ 18 years. Exclusion Criteria: Inability to give informed consent. Previously known oral disease

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Volunteers will be identified by the Head and Neck Service<br>25 volunteers (Part I - 8 volunteers. Part II - 17 volunteers). during the course of 12 months. The volunteers will be imaged with the endoscope, and the images will be evaluated visually and with qualitative (descriptive) statistics. | Device: Reflectance Confocal Microscopy (RCM) endoscope device<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| number of images with acceptable quality | Each image will be scored either 1 (completely unacceptable), 2 (unacceptable), 3 (possibly acceptable), 4 (acceptable) or 5 (very acceptable) relative to a reference standard The reference standard for appearance of adequate sectioning, resolution and contrast and for detectability of nuclear and cellular features will be the appearance of images and image quality, which we are intimately familiar with, based on the past several years of experience with the existing RCM device for which images of oral mucosa have been well-characterized, well-correlated to histology, and thus are well-understood. | 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Reflectance Confocal Microscopy, Normal Oral Tissue, 16-1652
Hypospadias and Exome: Identification of New Genes for Familial Hypospadias

Study Overview
=================
Brief Summary
-----------------
Hypospadias is the second most common malformation of the male genitalia and consists in a congenital hypoplasia of its ventral face. Hypospadias results from abnormal development of the penis that leaves the urethral meatus proximal to its normal glanular position. Meatus position may be located anywhere along the penile shaft, but more severe forms of hypospadias may have a urethral meatus located at the scrotum or perineum. Glandular and penile anterior represents approximately 70% of all the diagnosed cases. The frequency of family reached depend on the severity of hypospadias. The number of children which have hypospadias mutation discovered by classical technique is low. Families are often the cause of the discovery of new genes involved in sexual differentiation because they allow comparison of genomes of related persons, and detect more easily mutations.

Detailed Description
-----------------
The aim of this protocol is to search for new genes involved in genital malformations such as hypospadias. Addressed to families with usual causes of these malformations excluded. The search for these mutations will be done by exome sequencing in families where several cases of hypospadias were identified.

Official Title
-----------------
Hypospadias and Exome: Identification of New Genes for Familial Hypospadias

Conditions
-----------------
Hypospadias

Intervention / Treatment
-----------------
* Genetic: Exome sequencing


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Hypospadiac patients with a familial history of hypospadias Exclusion Criteria: Hypospadiac patients without a family history of hypospadias Hypospadiac patients with a family history of hypospadias where etiology is identified
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Hypospadias<br>Familial hypospadias trios (patients + parents) | Genetic: Exome sequencing<br>* Plain DNA sequencing<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| number of new genetic variants | exome sequencing | 1 day | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Hypospadias, exome sequencing, genital malformation
Brain Network Activation Analysis to Diagnose/Assess Treatment of Unipolar Major Depression and Bipolar I Depression

Study Overview
=================
Brief Summary
-----------------
The investigators are conducting this study to test the usefulness of a new type of analysis of electroencephalographic (EEG) recordings called brain network activation or BNA. BNA allows to identify patterns of activation in brain networks and to track their changes over time. The investigators want to examine the possible role of brain network activation (BNA) in the diagnosis of mood disorders and predicting improvement over time. The procedure conducted with patients diagnosed with a mood disorder will be compared to people who do not have a mood disorder.

Detailed Description
-----------------
Novel approach to ascertain use of BNA strategy and technology for the use in confirming diagnosis and predicting effect of specific treatment(s)in the various stages of affective/mood disorders. The goal is to develop non-invasive technology to confirm diagnosis via biological outcomes, and to study the preliminary data of predicting response/non-response to specific interventions before clinical effects are shown.

Official Title
-----------------
Potential Use of Brain Network Activation (BNA) Analysis Using Evoked Response Potentials to Diagnose Unipolar Major Depression and Bipolar I Depression and Assess Response to Treatment

Conditions
-----------------
Depression

Participation Criteria
=================
Eligibility Criteria
-----------------
Only subjects participating in another specific clinical trial will be invited to participate in this study. The inclusion/exclusion criteria for this observational study are based on the individual inclusion/exclusion criteria for each of the studies and can be found for each of the studies on this website. The specific studies and their numbers are found on their individual ClinicalTrials.gov site. INCLUSION CRITERIA: Bipolar I, depressed Major depression Meeting all criteria to sign the informed consent for each study included in this study who currently have a major depression (unipolar or bipolarI) EXCLUSION CRITERIA: Medically unstable (based on opinion of sponsor and PI Unable to meet the criteria to conform to the Rush University informed consent process

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation of changes in BNA with changes in mood symptoms | This is an observational study, so no other outcomes are measured | Beginning of study to end of study |