Developing Advanced MRI Methods for Detecting the Impact of Nutrients on Infant Brain Development

Study Overview
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Brief Summary
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The purpose is to study the effect of infant nutrition on brain development, as measured using Magnetic Resonance (MR) techniques. The investigators will collect detailed information about the diet of each of the infants, and seek to correlate this information with multiple MR measurements, including structural imaging, diffusion imaging, and functional connectivity. The MR scans will be performed at birth and 3 months of age. Dietary information collected will include detailed food diaries describing the feeding habits of the infants, and food frequency questionnaires to characterize the diet of the mother.

Detailed Description
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The purpose is to study the effect of infant nutrition on brain development, as measured using Magnetic Resonance (MR) techniques. The investigators will collect detailed information about the diet of each of the infants, and seek to correlate this information with multiple MR measurements, including structural imaging, diffusion imaging, and functional connectivity. The MR scans will be performed at birth and 3 months of age. Dietary information collected will include detailed food diaries describing the feeding habits of the infants, and food frequency questionnaires to characterize the diet of the mother.

Official Title
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Developing Advanced MRI Methods for Detecting the Impact of Nutrients on Infant Brain Development

Conditions
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Infant Development

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: full-term babies whose mothers have no known medical conditions or complications during pregnancy. Exclusion Criteria: preterm babies babies whose mothers have significant medical conditions and/or significant complications during pregnancy.

Ages Eligible for Study
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Maximum Age: 4 Months

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Infant Group 1<br>This group consist of healthy, full-term babies whose mothers have no known medical conditions or complications during pregnancy. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Magnetic Resonance Imaging to measure of brain metabolites, brain structures and brain function |  | Infants receive an MRI at 3 months of age | 
| Magnetic Resonance Imaging to measure of brain metabolites, brain structures and brain function |  | Infants receive an MRI scan at less than 2 weeks of age | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Nutritional analysis of mothers diet using a food frequency questionnaire |  | Mothers fill out questionnaire at three months after enrollment into the study | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Infant Nutrition, Magnetic resonance spectroscopy, Infant Brain Development, Diffusion weighted Imaging, Diffusion tensor tractography