Effects of Intensive Statin Treatment on Left Ventricular Function

Study Overview
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Brief Summary
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First acute anterior myocardial infarction in patients with primary PCI preoperative and postoperative 30 days intensive dose atorvastatin statin therapy compared with conventional -dose therapy , patients can improve left ventricular function , reduce major adverse cardiovascular events .

Official Title
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Effects of Intensive Statin Therapy on Left Ventricular Function for Patients With the First Acute Anterior Myocardial Infarction After Directly to Percutaneous Coronary Intervention.

Conditions
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Acute Anterior Myocardial Infarction

Intervention / Treatment
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* Drug: standard group
* Drug: intensive group


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ≥ 18 years of age the first time clinical diagnosis of acute anterior myocardial infarction , the time of onset ≤ 12 hours ,intends underwent emergency PCI informed consent Exclusion Criteria: Taking , or the need for long-term use of statins is greater than the initial dose treated with PCI again within a mouth active liver disease or liver dysfunction the diagnosis of myopathy severe renal insufficiency ( serum creatinine > 178umol / L ) Statin drug allergy or had a serious adverse reaction severe aortic stenosis or mitral stenosis , hypertrophic obstructive cardiomyopathy , pericardial disease pregnancy malignancy or any other end-stage diseases result in a life expectancy of < 6 months be participating in other clinical studies not suitable for inclusion of the other cases not treated with PCI

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: standard group<br>patients in this group received standard statin treatment： Atorvastatin statins 20mg / night . | Drug: standard group<br>* standard statin treatment:Atorvastatin statins 20mg / night .<br>* Other names: Lipitor;|
| Experimental: intensive group<br>patients in this group received intensive statin treatment： Admission atorvastatin statins the 80mg, after surgery，atorvastatin 40mg / night，and until 30 days after the operation , and thereafter 20mg / night . | Drug: intensive group<br>* intensive statin treatment： Admission atorvastatin statins the 80mg, after surgery，atorvastatin 40mg / night，and until 30 days after the operation<br>* Other names: intensive Lipitor;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| left ventricular function | ultrasonic observation of left ventricular end-diastolic diameter | 30 days | 
| left ventricular function | ultrasonic observation of left ventricular end-systolic volume | 30 days | 
| left ventricular function | ultrasonic observation of left ventricular fractional shortening RWSI | 30 days | 
| left ventricular function | ultrasonic observation of the left ventricular ejection fraction | 30 days | 
| left ventricular function | ultrasonic observation of E/A | 30 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the left ventricular function |  | 6 months | 
| the left ventricular function |  | 1 year | 
| plasma brain natriuretic peptide |  | 30days | 
| plasma brain natriuretic peptide |  | 6 months | 
| plasma brain natriuretic peptide |  | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Acute anterior myocardial infarction, Percutaneous coronary stent implantation, Intensive statin therapy, Left ventricular function