Effect of Natural Antibacterial Mouthwash on Taste, Salivary pH and Bacteria in High Caries Risk pt

Study Overview
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Brief Summary
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Evaluate the effect of propolis extract mouthwash and pomegranate extract mouthwash on taste alteration, salivary pH and antibacterial activity against streptococcus mutans in high caries risk patients.

Detailed Description
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This study will be carried out to evaluate and compare the effect of propolis extract mouthwash and pomegranate (botanical name: Punica granatum) extract mouthwash on taste alteration, salivary pH and antibacterial activity against streptococcus mutans in high caries risk patients. Thats by taking unstimulated saliva samples at the morning before using the mouthwash, then taking another one after using the mouthwash and finally after 7 days, to make a bacterial culture and measure the salivary pH by a digital pH meter and evaluate taste changes by a questionnaire.

Official Title
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Effect of Propolis and Pomegranate Extract Mouthwash on Taste Alteration, Salivary pH and Antibacterial Activity in High Caries Risk Patients

Conditions
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Decay, Dental

Intervention / Treatment
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* Other: chlorhexidine
* Other: saline
* Other: Propolis extract
* Other: pomegranate extract


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: High caries risk patients defined according to American Dental Association (ADA) Systematically healthy Not taking any medication interfering with saliva secretion Subjects who signed informed consent Age range from 17-50 years Exclusion Criteria: Subjects suffering from any medical or systematic disease Smokers Pregnant females Allergy to any of the mouthwash ingredients Patients older than 50 years

Ages Eligible for Study
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Minimum Age: 17 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Propolis extract<br>intervention | Other: Propolis extract<br>* antibacterial mouthwash<br>|
| Experimental: Pomegranate extract<br>intervention | Other: pomegranate extract<br>* antibacterial mouthwash<br>|
| Active Comparator: Chlorhexidine<br>comparator | Other: chlorhexidine<br>* antibacterial and anti-inflammatory mouthwash<br>* Other names: hexitol;|
| Placebo Comparator: Saline<br>comparator | Other: saline<br>* anti-inflammatory cleansing mouthwash<br>* Other names: NaCl solution;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Taste alteration | taste changes will be measured by a questionnaire | One week | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Salivary pH | salivary pH will be measured by digital pH meter | one week |