Methylphenidate Effect on Humphrey Visual Fields

Study Overview
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Brief Summary
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Study will include adults with abnormal visual fields. Half of them will be given either methylphenidate 10mg 2 hours before repeating the visual field test. the rest will serve as controls. All Subjects will also have a complete eye examination, a short questionnaire and a questionnaire to screen for attention deficit disorder. The investigators will compare the visual field results between the 2 tests.

Detailed Description
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Healthy adults with abnormal visual fields will be offered to participate Subjects will have a complete ophthalmic examination including dilated fundus examination. Subjects with clear explanation for a visual field defect (e.g. optic neuropathy or retinal disorder) will be excluded from the study the subjects will be randomly assigned to the study group and control group using a 1:1 allocation. Subjects in the study group will be provided with a single tablet of methylphenidate 10 mg to be taken orally 2 hours before repeating their visual field test. The control group will not receive any placebo Both groups will repeat their visual fields. Both groups will fill out a short questionnaire to evaluate their experience in the second visual field test. The study group will also fill out a screening questionnaire to rule out previously undiagnosed attention deficit disorder. Two experienced ophthalmologists will separately interpret the visual fields results and compare the first and second visual fields of each subject, while being blinded to which group he was in. Subjects will be provided with their test results and the ophthalmologist interpretation.

Official Title
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Methylphenidate Effect on Performing Humphrey Visual Fields

Conditions
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Visual Field Tests

Intervention / Treatment
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* Drug: methylphenidate
* Other: guidance


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: abnormal visual fields must be able to swallow pills Exclusion Criteria: psychiatric disorder dementia ocular disorder which is known to cause abnormal visual fields prescription of psychoactive medications visual acuity lower than 20/100 cardiac arrhythmia hypersensitivity to methylphenidate prescription of warfarin

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 120 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: methylphenidate provided<br>the study group will be given a single pill containing methylphenidate 10mg to be taken 2 hours before their visual field test | Drug: methylphenidate<br>* a single dose of methylphenidate 10 mg to be taken orally in the morning<br>* Other names: Ritalin;Other: guidance<br>* subjects will be given an explanation and advice about how to perform well in visual field testing<br>|
| Active Comparator: control<br>control group will not be given any placebo and will perform a repeat visual field testing without any prior preparation | Other: guidance<br>* subjects will be given an explanation and advice about how to perform well in visual field testing<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| improvement rate of a repeat visual field result | the percentage of subjects whose second (repeat) visual field has improved compared to the first visual field - as interpreted by independent blinded ophthalmologists | immediate | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Humphrey visual field Mean Deviation (MD) | the MD of the Humphrey visual field in the study and control groups will be compared | immediate | 
| Humphrey visual field severity score | based on the Humphrey visual field gray scale each visual field will be given a score between 1 and 4. 1 = normal 2=enlargement of the blind spot 3=either a nasal or temporal visual field 4= diffuse visual field loss | immediate | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Humphrey visual fields, methylphenidate, attention deficit disorder, MoCa questionnaire