Evaluation of the Efficacy of Intense Pulse Light Combined With Lipiflow in the Treatment of Meibomian Gland Dysfunction

Study Overview
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Brief Summary
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To compare the effect of IPL combined with lipiflow and IPL combined with meibomian gland massage in treating meibomian gland dysfunction of different degrees ,focusing on effective rate, lasting time and changes of meibomian gland function and morphology.

Detailed Description
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To divide all participants into two groups, group one treated with IPL combined with Lipiflow and group two treated with IPL combined with meibomian gland massage.The following parameters were recorded after treatment: the effective rate, lasting time and changes of meibomian gland function and morphology.All parameters were compared between the two groups.

Official Title
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Evaluation of the Efficacy of Intense Pulse Light Combined With Lipiflow in the Treatment of Meibomian Gland Dysfunction

Conditions
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Meibomian Gland Dysfunction

Intervention / Treatment
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* Procedure: IPL/Lipiflow
* Procedure: IPL/MGX


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients with meibomian gland dysfunction patients with ocular discomfort skin type:FitzpatricⅠ-Ⅳ Exclusion Criteria: patients with acute ocular inflammation eye surgery history in the last 12 months patients who have received IPL or Lipiflow in the last 12 months patients who wear contact lens in last one month

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: IPL/Lipiflow<br>the group in which patients treated with IPL combined with lipiflow | Procedure: IPL/Lipiflow<br>* To treat patients with MGD using intense pulsed light combined with lipiflow<br>|
| Active Comparator: IPL/MGX<br>the group in which patients treated with IPL combined with meibomian gland massage | Procedure: IPL/MGX<br>* To treat patients with MGD using intense pulsed light combined with meibomian gland massage<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| ocular surface disease index(OSDI) | The OSDI is assessed on a scale of 0 to 100,with higher scores representing greater disability | 6 months | 
| meibomian gland expressibility score and meibum quality score | The score is on a scale of 0 to 6.The higher scores, the severity of the meibomian gland function(the highest score is 6 and the lowest score is 0) | 6 months | 
| meibomian gland dropout score | the higher scores, the severity of the meibomian gland morphology(The highest score is 6 and the lowest score is 0) | 6 months | 
| Breakup time | the shorter time, the poorer of the tear film stability | 6 months |