Aflibercept as Adjunctive Treatment for Filtration Surgery in Neovascular Glaucoma

Study Overview
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Brief Summary
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Purpose: To investigate intravitreal aflibercept (IVA) injection as an adjunctive treatment to trabeculectomy with mitomycin C (TMC) and panretinal photocoagulation (PRP) for neovascular glaucoma (NVG). Setting: Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand Study design: Prospective interventional case series Methods: PRP and IVA (2 mg/0.05 ml) injection were given, and TMC was performed within 2 weeks after IVA. Additional PRP, laser suture lysis, subconjunctival 5-fluorouracil injection, and bleb needling were performed after TMC if indicated. Best-collected visual acuity (BCVA), intraocular pressure (IOP), surgical complications, and number of anti-glaucoma medications were collected.

Official Title
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Aflibercept as Adjunctive Treatment for Filtration Surgery in Neovascular

Conditions
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Intraocular Pressure, Neovascular Glaucoma, Vascular Endothelial Growth Factor Overexpression, Glaucoma Secondary to Eye Inflammation

Intervention / Treatment
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* Drug: Aflibercept Ophthalmic


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Consecutive patients with neovascular glaucoma who presented at the Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand during November 2018 to October 2019. Aged more than 18 year-old Exclusion Criteria: Patients who received any anti-vascular endothelial growth factor treatment before participation

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Aflibercept Ophthalmic|Panretinal photocoagulation and intravitreal aflibercept (2 mg/0.05 ml) injection were given, and trabeculectomy with mitomycin C was performed within 2 weeks after intravitreal aflibercept injection.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Intraocular pressure | Intraocular pressure after trabeculectomy | Post-operative on day 1st | 
| Intraocular pressure | Intraocular pressure after trabeculectomy | Post-operative on day 7th | 
| Intraocular pressure | Intraocular pressure after trabeculectomy | Post-operative on month 3rd | 
| Intraocular pressure | Intraocular pressure after trabeculectomy | Post-operative on month 6th | 
| Intraocular pressure | Intraocular pressure after trabeculectomy | Post-operative on month 12th | 
| Intraocular pressure | Intraocular pressure after trabeculectomy | Post-operative on month 18th | 
| Intraocular pressure | Intraocular pressure after trabeculectomy | Post-operative on month 24th | 
| Intraocular pressure | Intraocular pressure after trabeculectomy | Post-operative on month 30th | 
| Intraocular pressure | Intraocular pressure after trabeculectomy | Post-operative on month 36th | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Visual acuity | Visual acuity of the studied eye | Post-operative on day 1st | 
| Visual acuity | Visual acuity of the studied eye | Post-operative on day 7th | 
| Visual acuity | Visual acuity of the studied eye | Post-operative on month 3rd | 
| Visual acuity | Visual acuity of the studied eye | Post-operative on month 6th | 
| Visual acuity | Visual acuity of the studied eye | Post-operative on month 12th | 
| Visual acuity | Visual acuity of the studied eye | Post-operative on month 18th | 
| Visual acuity | Visual acuity of the studied eye | Post-operative on month 24th | 
| Visual acuity | Visual acuity of the studied eye | Post-operative on month 30th | 
| Visual acuity | Visual acuity of the studied eye | Post-operative on month 36th | 
| Numbers of medication | Numbers of anti-glaucoma medications | Post-operative on month12th | 
| Numbers of medication | Numbers of anti-glaucoma medications | Post-operative on month 24th | 
| Numbers of medication | Numbers of anti-glaucoma medications | Post-operative on month 36th |