Brain-derived Neurotrophic Factor and Cogntive Function

Study Overview
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Brief Summary
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Individuals with type 2 diabetes have an increased risk of developing cognitive dysfunction followed by dementia in late life. Obesity, physical inactivity and systemic low-grade inflammation are strong risk factors and play a crucial role in this network of diseases. Brain-derived Neurotrophic factor (BDNF) is produced in brain as well as several tissues outside brain eg muscle cells. Low BDNF are associated with cognitive dysfuction, obesity and type 2 diabetes. The investigators include 200 individuals divided into three groups: 80 individuals with type 2 diabetes, 80 age and BMI-matched controls and 40 individuals with impaired glucose tolerance. The project will test the hypothesis, that low systemic BDNF are associated with accumulation of abdominal fat, cognitive dysfunction and insulin resistence with different effect in men and women.

Detailed Description
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Methods: 200 individuals in age 40-65 years are recruited and categorized into 3 groups: 1. Type 2 Diabetes, 2. Impaired glucose Tolerance and 3. Normal Glucose Tolerance. Groups are supposed to be age and BMI-matched. Measurements of systemic BDNF, cogntive function (memory, attention and langue), fitness, bodycomposition, glucose metabolism and systemic inflammation are done. Multiple regression analysis are perfomed to explain variablity in cognitive function, with age, visceral fat and BDNF as explanotory varibales.

Official Title
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Brain-derived Neurotrophic Factor: A Link to Obesity, Insulin Resistance and Cognitive Dysfunktion?

Conditions
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Cognitive Dysfunction, Glucose Metabolism, Low-grade Inflammation, Bodycomposition

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 40-65 years of age Exclusion Criteria: Chronic inflammatory diseases or infectious diseaases within 3 month prior to visit Fasting glucose > 12 mmol/l Hypertension: systolic >180 mmHg and Diastolic >110 mmHg Intake of more than 2 oral antidiabetic drugs or any TZD drung within 3 months before recruitment

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Type 2 Diabetes<br>80 individuals with type 2 Diabetes, confirmed by an OGTT, age 40-65 years, BMI > 18.5 kg/m2 fatsing plasma glucose < 12 mmol/l | |
| Impaired glucose tolerance<br>40 individuals with impaired glucose tolerance. age 40 -65 years, BMI > 18. 5 kg/m2 | |
| Normal glucose tolerance<br>80 Individuals without type 2 diabetes Age 40-65 years, BMI >18.5 kg/m2. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Systemic Brain derived neurotrophic factor | Circulating Brain derived neurotropic factor will be analyzed in plasma and serum in middelaged volunteers. Levels will be related to on one hand metabolic parameteres such as insulin sensitivity and glucose tolerance and on the other hand to cognitive functions measured by a cognitive test battery. | Baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cognitive function and bodycompisition | Results from cogntive measurements will by multiple regression analysis be related to bodycomposition (Intraabdominal fat, total bodyfat, waist) and fitness (single stage max-test). | Baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Brain-derived Neurotrophic factor, Low-grade inflammation, Cognitive dysfunction