Cord Milking and Activity Of The Immune System In Preterm Infants

Study Overview
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Brief Summary
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In the embry life there is a passage of IgG type, from the mother to tha embryoyo and only in the age of 3-5 month after birth the infant start to develop them by himself. In preterm infants the starting point of the level of the IgG's is lower from the level of term infants. Delayed cord clamping /milking it was prooved in many researches as benificial in terms of : levels of hemoglobin; hematocrit and feritin in the neonats. Also benefits were proved by means of less need for blood tranfusion, less intra ventricular hemorrhage; necrotzing entero colitis and iron deficiency anemia. The hypothesis is that delayed clamping /milking it will increse the level of IgG's in preterm infants. The end point hypothesis is that delayed cord clamping /milking cause to less fever disease or hospitalization it the neonats.

Detailed Description
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In this study we come to a prove that if we miking the cord in preterm infats we will increse the level of IgG .

Official Title
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Cord Milking and Activity Of The Immune System In Preterm Infants

Conditions
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Preterm Delivery

Intervention / Treatment
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* Other: CORD MILKING


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: PRETERM INFANS BETWEEN 24+0/7 TO 36 6/7 WEEKS. NEWBORN FOR MOTHER WHO AGREE TO PARTICIPATE IN THE RESEARCH WHO DELIVER IN NORMAL DELIVERY / PLANED OR URGENT CESARIAN DELIVERY Exclusion Criteria: INTRA UTERINE GROWTH RESTRICTION, INFANT UNDER 10% TO AGE OF PREGNANCY. MOTHER WHO IS NOT WILLING TO PARTICIPATE IN RESEARCH. NEONATES TO MOTHER WHOM SUSPECTED TO BE IMMUNO- COMPROMISED OR HAVING INFECTION AROUND DELIVERY.

Ages Eligible for Study
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Minimum Age: 24 Weeks
Maximum Age: 37 Weeks

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Intervention Model: Single Group Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: CORD MILKING<br>WITHOUT MILKING | Other: CORD MILKING<br>* MILKING OF UMBILICAL CORD OF THE BABY<br>* Other names: UMBLICAL MILKING;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| levels of IgG in preterm infats | Blood test for IgG's level from the baby in : at delivery . 24 hours after delivery. before discharg from hospital | 24 hours after delivery and after 24 hours.. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mother's telephone questioning about the infant disease: fiver / hospitalization/tretment wit antibiotic. | Phone call interview of the mother in 3 and 6 month from delivery about : emergengy room admission; hospitalization, fever disease and antibiotic treatment in this time period. | 3 and 6 month after delivery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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DELAYED CORD CLAMPING, MILKING OF CORD, PREMATURE INFANTS, LEVEL OF IgG IN NEONATES