High Intensity Interval Training in Geriatrics

Study Overview
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Brief Summary
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This is a pilot study for evaluating the feasibility of using High Intensity Interval Training in geriatric hospitalized patients compared to the standard current rehabilitation practice.

Detailed Description
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High Intensity Interval Training (HIIT) has shown a superior effectiveness and efficiency when compared to Moderate Intensity Continuous Training (MICT) in several types of patients and in healthy subjects. There are no data on HIIT in a general geriatric population. This study is a pilot study evaluating the feasibility of using HIIT in geriatric hospitalized patients compared to the standard current rehabilitation practice without HIIT. It is our desire to perform a larger randomized comparative trial between HIIT and MICT if the pilot study proves its feasibility.

Official Title
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High Intensity Interval Training for thE Rehabilitation of Geriatric Patients - a Feasibility Pilot studY.

Conditions
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Muscle Weakness, Gait, Unsteady

Intervention / Treatment
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* Other: high intensity interval training-HIIT
* Other: Traditionnal group rehabilitation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients aged 65 years and older hospitalized for rehabilitation after an acute medical condition Expected duration of the rehabilitation ≥ 2 weeks Ability to follow instructions to perform a Timed up and Go Test Ability to perform exercises Willing to participate in 4 sessions of HIIT per week for 2 weeks Exclusion Criteria: Any acute condition with tachycardia, hypotension or fever. Abnormal cycle ergometer stress test with significant ECG modification decrease of more than 20 mmHg of the blood pressure with exercise angina ST depression at a workload <6 METs Inability to reach an intensity of 15/20 in the Borg's scale of perceived exertion Any unresolved acute medical or surgical condition of the following kind: acute heart failure acute coronary syndrome < 1 month strole < 1 month active pericarditis / myocarditis / endocarditis thromboembolic disease with < 2 weeks of anticoagulation acute infection requiring intravenous treatment ongoing intravenous perfusion surgery < 2 months recent bone fracture Previous episode of primary cardiac arrest (ie, cardiac arrest that did not occur in the presence of an acute myocardial infarction or during a cardiac procedure). Severe heart failure (NYHA III and IV) Severe stenotic or regurgitant valvular disease Uncontrolled hypertension at rest (SBP≥160mmHg, DBP≥100mmHg) Uncontrolled dysrhythmia Non-sustained ventricular tachycardia with exercise Implanted defibrillator Obstructive cardiomyopathy Resting HR > 100/min Severe peripheral artery disease Severe COPD (VEMS < 50%) Exercise-induced asthma Oxygen dependency Muscular-skeletal anomaly that may limit exercise participation Delirium Inability to follow instructions Inability to consent

Ages Eligible for Study
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Minimum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: high intensity interval training-HIIT<br>HIIT 4 times a week, 30 minutes duration | Other: high intensity interval training-HIIT<br>* HIIT 4 times a week, 30 minutes duration<br>|
| Active Comparator: Traditionnal rehabilitation<br>Traditionnal group rehabilitation 3 times a week, 1 hour duration. | Other: Traditionnal group rehabilitation<br>* Traditionnal group rehabilitation, 3 times a week, 1 hour duration<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Proportion of patients who complete the rehabilitation program |  | 2 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Distance walked in the 6MWT |  | 2 weeks | 
| Muscle strength assessed for the upper and lower extremities | upper extremity : handgrip strength using the Baseline Pneumatic Bulb Hand Dynamometer Pinch Gauge; Lower exremity : knee flexion & extension and ankle flexion & extension using Microfet2™portable Dynamometer. | 2 weeks | 
| Step variability changes as a measure of quality of ambulation | Variability measured with GaitRite step analysis system | 2 weeks |