linjc16/ctgov huggingface dataset:
Efficacy of Licorice on Reducing Salivary Streptococcus Mutans Versus Chlorohexidine in Caries Risk Patients

Study Overview
=================
Brief Summary
-----------------
To compare the effect of a natural herbal licorice containing preventive measure alternative to chlorohexidine preventive measure to decrease the effect of streptococcus mutans.

Detailed Description
-----------------
A total number of fifty-two patients will be enrolled in the study. They will be divided into two groups: study group and control group. Study group will be subjected to licorice mouthwash and the control will be subjected to chlorohexidine mouth wash. Salivary bacterial count will be evaluated for both groups.

Official Title
-----------------
Evaluation the Efficacy of a Herbal Licorice on Reducing Salivary Streptococcus Mutans Levels (A Randomized Clinical Trial)

Conditions
-----------------
Caries, Dental

Intervention / Treatment
-----------------
* Other: licorice extract mouthwash
* Other: chlorohexidine mouthwash


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: over 18 years old co-operative patients not allergic to licorice not allergic to chlorohexidine Exclusion Criteria: pregnancy allergic patients to licorice allergic patients to chlorohexidine lack of compliance evidence of parafunctional habits patients with periodontal disease xerostomia participants that receive any microbial agent two weeks prior to the study

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: licorice extract mouthwash<br>administration of a mouthwash containing licorice as a preventive measure to high caries risk patients (faculty of pharmacy, cairo university) | Other: licorice extract mouthwash<br>* mouth rinse that contains a natural herbal licorice root extract used as a preventive measure that reduce caries index.<br>|
| Placebo Comparator: chlorohexidine mouthwash<br>administration of chlorohexidine 0.2% in 1:1 diluation mouthwash that is broad spectrum antimicrobial activity to high caries risk patients | Other: chlorohexidine mouthwash<br>* mouth wash that contains chlorohexidine as an active component<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| salivary bacterial count | streotococcus mutans bacterial count | after one week | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Streptococcus Mutans, licorice, chlorohexidine, caries index
Inflammasome Activation and Cortisol Metabolism in Obese Women With Recurrent Miscarriage

Study Overview
=================
Brief Summary
-----------------
The prevalence of obesity among women of reproductive age is increasing. Obesity represents a chronic low-grade inflammatory state and NLRP3 inflammasome plays a pivotal role in obesity-induced inflammation. Obesity is associated with an increased risk of recurrent miscarriage (RM), but the underlying mechanisms are unclear. Abnormal inflammasome activation was also identified in the endometrium of women who experienced RM. Given inflammasome activation has emerged as common pathophysiology in obesity-related disorder and RM, the investigators wonder whether inflammasome activation occurs in the uterine macrophages of obese women, and result in early reproductive failure.

Detailed Description
-----------------
pending

Official Title
-----------------
Dr. Pao-Lin Kuo (Department of Obstetrics and Gynecology

Conditions
-----------------
Obesity, Inflammation

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All women have conceived naturally without the aid of assisted reproductive technologies Exclusion Criteria: N/A

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Validity of inflammatory markers | Use the levels of hsCRP and CA125 provides the information about inflammation. | 1 Day |
Collection of Information-Rich Type 1 Diabetes Data

Study Overview
=================
Brief Summary
-----------------
The aim of this clinical study was to obtain type 1 diabetes data to identify models for glucose prediction and control and to construct a physiological pharmaco-kinetic/pharmaco-dynamic computer model of a type 1 diabetic person.

Conditions
-----------------
Type 1 Diabetes

Intervention / Treatment
-----------------
* Drug: Insulin Aspart
* Other: Exercise
* Dietary Supplement: Carbohydrate


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: diabetes duration > 5 years HbA1c < or = 7.2% CSII treated for > 3 months Capable of being moderately, physically active for 20 minutes Exclusion Criteria: symptoms of diabetic late complications except simplex retinopathy pregnancy or nursing

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Intervention Model: Single Group Assignment


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Insulin Aspart|Insulin bolus with and without carbohydrate intake.|
|Other: Exercise|Exercise on tread mill|
|Dietary Supplement: Carbohydrate|Carbohydrate intake|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Artificial pancreas, Model predictive control, Virtual patient
Safety and Efficacy of Punctum Plug Delivery System in Subjects With Open-Angle Glaucoma or Ocular Hypertension

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine if the Punctum Plug Delivery System (PPDS) is safe and effective in controlling intraocular pressure in patients with open-angle glaucoma or ocular hypertension.

Official Title
-----------------
A Phase II, Randomized, Masked, Parallel-Group Study of Safety and Preliminary Efficacy of the Punctum Plug Delivery System in Subjects With Primary Open Angle Glaucoma or Ocular Hypertension

Conditions
-----------------
Glaucoma, Ocular Hypertension

Intervention / Treatment
-----------------
* Drug: Latanoprost-PPDS
* Drug: Latanoprost-PPDS
* Drug: Latanoprost-PPDS


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Over 18 yrs with open-angle glaucoma or ocular hypertension Subjects who have a best-corrected visual acuity of 20/100 or better. Exclusion Criteria: Uncontrolled medical conditions. Subjects who wear contact lenses. Subjects requiring chronic topical artificial tears, lubricants, and/or requiring any other chronic topical medications. Subjects who have a history of chronic or recurrent inflammatory eye disease.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>Low Latanoprost-PPDS | Drug: Latanoprost-PPDS<br>* Control of IOP compared to baseline for the low dose of Latanoprost-PPDS for 4 months or until loss of efficacy<br>|
| Experimental: 2<br>Medium Latanoprost-PPDS | Drug: Latanoprost-PPDS<br>* Control of IOP compared to baseline for the medium dose of Latanoprost-PPDS for 4 months or until loss of efficacy<br>|
| Experimental: 3<br>High Latanoprost-PPDS | Drug: Latanoprost-PPDS<br>* Control of IOP compared to baseline for the high dose of Latanoprost-PPDS for 4 months or until loss of efficacy<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| IOP change from baseline |  | 12 Weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
glaucoma, ocular hypertension, IOP
145/5000 Oral State and Knowledge, Attitudes and Practices of Pregnant Women on Their Oral Health and That of Their Unborn Child

Study Overview
=================
Brief Summary
-----------------
Pregnancy is a physiological condition which is accompanied by changes in the oral sphere which may increase the need for oral care and prevention. The role of dental surgeons is to provide appropriate care and to provide information on the prevention of oral diseases of pregnant women but also of their unborn baby. Investigators wants to determine if pregnants women know that national health insurance has set up a free dental care preventive examination.

Detailed Description
-----------------
Investigators will describe the knowledge, attitudes and practices of pregnant women consulting at the maternity of Bordeaux University Hospital with regard to the oral examination of health insurance. This study will also Evaluate the care needs and the acceptability of oral screening and study the association between the use of prenatal health insurance and dental health.

Official Title
-----------------
Oral State and Knowledge, Attitudes and Practices of Pregnant Women on Their Oral Health and That of Their Unborn Child

Conditions
-----------------
Dental Care

Intervention / Treatment
-----------------
* Other: Survey
* Other: dental care


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Pregnant women Exclusion Criteria: Patient refuses to participate in the study. Persons under guardianship No understanding of oral French. People with decompensated severe psychiatric disorder or severe cognitive impairment.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Pregnancy women<br> | Other: Survey<br>* pregnant women will answer to a survey regarding their oral health knowledge, attitudes and practices for themselves and their unborn child<br>Other: dental care<br>* pregnant women will have a dental care<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Use of prenatal health insurance for free dental examination | The use of this dental examination will be assessed with a survey | Enrollment | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
prevention, dental care, pregnancy
The Effect of Dexmedetomidine on Decreasing Emergence Agitation and Delirium in Pediatric Patients Undergoing Strabismus Surgery

Study Overview
=================
Brief Summary
-----------------
Postoperative agitation in children is a well-documented clinical phenomenon with incidence ranging from 10% to 67%. Recently, dexmedetomidine has been investigated extensively in the pediatric population and there is now increasing evidence to support the use of this drug as sedative and anesthetic adjunct in children. The purpose of this study is to determine whether prophylactic use of intraoperative dexmedetomidine to prevent of emergence delirium.

Conditions
-----------------
Strabismus

Intervention / Treatment
-----------------
* Drug: Dexmedetomidine
* Drug: placebo group


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: the patient undergoing the strabismus surgery in severance hospital Exclusion Criteria: delayed development mental retardation cerebral palsy preoperative EKG abnormality e.g. cardiovascular conduction disorder

Ages Eligible for Study
-----------------
Maximum Age: 5 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: dexmedetomidine<br> | Drug: Dexmedetomidine<br>* After, induction of general anesthesia, dexmedetomidine 0.2 mcg/kg/hr continuous intravenous infused during the surgery<br>|
| Placebo Comparator: placebo<br> | Drug: placebo group<br>* normal saline_02mcg/kg/hr<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| objective pain score | 1. Objective pain score(OPS) Blood pressure 0 2 points crying 0 2points movement 0 2points agitation 0 2points posture 0 2points complain of pain(where appropiraate by age) 0 2points total 0 10 points | immediate postoperative period up to 1hour after surgery | 
| pediatric anesthesia emergence delirium (PAED) scale | 2. pediatric anesthesia emergence delirium (PAED) scale The Child makes eye contact with the caregiver 0 4 The child's actions are purposeful. 0 4 The child is aware of his'her surroundings. 0 4 The child is restless. 0 4 The child is insonsolable. 0 4 total 0 20 points | immediate postoperative period up to 1hour after surgery | 
| 5-point agitation scale | 3. Scoring system for emergence agitation (behavior score) Sleeping Awake and calm Irritable and crying Inconsolable crying Severe restlessness and disorientation | immediate postoperative period up to 1hour after surgery |
Observational Follow-up Extension Study of AFF002 and AFF004A in Patients With Alzheimer's Disease

Study Overview
=================
Brief Summary
-----------------
This study examines the long term Safety Follow-up of first patients vaccinated with AD02.

Detailed Description
-----------------
Patients who have received AD02 during AFF002 and AFF004A will be observed.

Official Title
-----------------
Observational Follow-up Extension Study to Evaluate Long-term Safety and Tolerability of Immunizations With AFFITOPE AD02 Applied During AFFiRiS002 and AFF004A in Patients With Alzheimer's Disease

Conditions
-----------------
Alzheimer´s Disease

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: participation in AFF002 and AFF004A Exclusion Criteria: no vaccination with AD02
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Safety | collection and evaluation of AEs, SAEs | up to 2 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Vaccination follow-up
Modelling Tau Distribution From DTI With Generative Adversarial Network for Alzheimer's Disease Diagnosis

Study Overview
=================
Brief Summary
-----------------
The most significant impact of this project is to propose for the first time a novel generative adversarial network (GAN), as one kind of deep learning architecture, to automatically generate synthetic PET images reflecting tau deposition, from brain DTI images. If successful, this framework will become the most state-of-the-art approach to simulate the stereotypical pattern of intracerebral tau accumulation and distribution in vivo. Synthetic tau-PET images via DTI, possessing overwhelming superiority in radiation-free, non-invasiveness and cost-effectiveness, will potentially serve as one of alternative modalities of PET in detecting tau-load and probably outperform PET on accessibility, generalizability, and availability in future, making it much more attractive in clinical application. A big conceptual shift may occur preferring a fire-new tau-PET simulated via DTI. The DTI data-driven deep learning framework to be created in this project will constitute an accurate, robust, clinically applicable and explainable tool to efficiently categorize the subjects into tau-burden positive and tau-burden negative cases, which will undoubtedly contribute to both clinical and research activities.

Official Title
-----------------
Modelling Tau Deposition and Distribution From Diffusion Tensor Imaging With Generative Adversarial Network for Alzheimer's Disease Diagnosis

Conditions
-----------------
Alzheimer's Disease Diagnosis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: With the age of 55 years and above With brain MRI taken within ±6 months from the date of clinically confirmed diagnosis of AD, MCI or normal cognition. Exclusion Criteria: AD with mixed dementia Non-AD dementia History of severe traumatic brain injury, severe depression, stroke, brain tumors, and incident major systemic illness

Ages Eligible for Study
-----------------
Minimum Age: 55 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Controls<br> | |
| Mild cognitive impairment<br> | |
| AD dementia<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Structural similarity index to measure the similarity between synthetic image and ground truth for 20% of data in testing set |  | Through study completion, an average of 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Generative Adversarial Network, Tau, Diffusion Tensor Imaging
Iron Metabolism in Cystic Fibrosis

Study Overview
=================
Brief Summary
-----------------
Iron is a biologically essential micronutrient. Iron deficiency alters erythropoiesis and is considered as a major cause of disability worldwide. Interestingly, iron overload is never observed in cystic fibrosis contrarily to others chronic respiratory diseases. Moreover, iron deficiency reported prevalence in CF is very high (up to 60% in retrospective series) and is correlated to an alteration of respiratory function. Cystic fibrosis patients should be tested annually for iron deficiency. Serum ferritin is the best diagnosis tool for iron deficiency (specificity 87% for a threshold < 30 µg/L). Previously published studies used less performant markers such as serum iron (< 12 µmol/L) or transferrin saturation (< 12%), which are markedly influenced by the systemic inflammation. CF patients experiences frequent pulmonary exacerbations leading to systemic inflammation: iron stores should therefore be assessed at optimal time with no inflammation. The I-MUCO study aims to determine the exact prevalence of iron deficiency in CF patients. We aimed to identify risk factors for iron deficiency onset.

Official Title
-----------------
Prevalence and Incidence of Iron Deficiency in Cystic Fibrosis

Conditions
-----------------
Iron Metabolism, Cystic Fibrosis

Intervention / Treatment
-----------------
* Other: iron stores assessment.


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Cystic fibrosis genetically proven. Age ≥ 18 years Systematic annual follow-up. Exclusion Criteria: Dietary or drugs iron supplements Systemic inflammation or pulmonary exacerbation Lung transplantation

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: iron stores assessment.|assessment of iron stores by measuring serum ferritin level (mandatory), serum iron and transferrin saturation.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| prevalence of iron deficiency defined by serum ferritin ≤ 30 µg/L without inflammatory syndrome (C-reactive protein < 5 mg/L). | from inclusion to first documented up to 1 year | 1 year |
Health Literacy Among Caregivers of Children With IgE-mediated Allergy With Risk of Anaphylaxis

Study Overview
=================
Brief Summary
-----------------
Research on health literacy among caregivers of children with IgE-mediated allergy at risk of anaphylaxis (life-threatening allergic reaction). Health literacy is a person's ability to understand health information so that they can maintain or improve their health and quality of life (of themself and children). The aim of the study is to test the general knowledge of anaphylaxis. Furthermore we test the extent to which caregivers consider themselves able to recognize and to treat anaphylaxis.

Official Title
-----------------
Health Literacy Among Caregivers of Children With IgE-mediated Allergy With Risk of Anaphylaxis

Conditions
-----------------
Health Literacy, Anaphylaxis

Intervention / Treatment
-----------------
* Other: Teaching


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: caregivers of children with IgE-mediated allergy with risk of anaphylaxis (adults, grandparents, school caregivers etc.). minimum 18 years old. signed informed consent Exclusion Criteria: none

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Teaching|Teaching session about anaphylaxis|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| General knowledge of anaphylaxis. | Knowledge Quiz | 1.5 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The extent to which caregivers consider themselves able to recognize and to treat anaphylaxis. | Numeric scoring scale (0= cannot do at all, 5= highly certain can do) | 1.5 year |