Impact of Neuropsychological Alteration of Patients With Eating Disorders

Study Overview
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Brief Summary
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Eating disorders are multifactorial disorders currently conceptualized in a biopsychosocial model, but pathophysiology remains relatively unknown, and robust etiological models to guide treatment are therefore lacking. Different endophenotypes and neurocognitive vulnerability factors have been found in eating disorders including decision making abnormalities. The investigators hypothesize that decision making abnormalities are associated with a lower level of functioning and quality of life which could lead to social and interpersonal difficulties. The investigators also hypothesize that these anomalies are associated with a particular clinical profile (more restrictive profile, more hyperactivity, less insight on the disease and desire for care ...).

Detailed Description
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The investigators will recruit a total of 200 patients with an eating disorder in the university hospital of Montpellier. Participation consists of a one-day visit with a multidisciplinary assessment. No action is specific to research. This is the usual management of patients with eating disorders addressed to our department.

Official Title
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Impact of Neuropsychological Alteration of Decision-making Abilities on the Functioning of Patients With Eating Disorders

Conditions
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Eating Disorder

Participation Criteria
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Eligibility Criteria
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Inclusion criteria : Patient with an eating disorder according to DSM-V criteria Patient aged from 15 to 65 years Patient who performs the day-hospital evaluation Patient affiliated to a French social security system Patient able to understand the nature, the aim and the methodology of the study For minor one of the legal guardians gave his consent Exclusion criteria: Patient in an unstable somatic state (eg severe metabolic disorder making impossible or unreliable neuropsychological assessments) Patient's refusal to participate Patient protected by law (guardianship or curatorship) Pregnant or nursing women. A dosage of βHCG will be performed to ensure the absence of pregnancy.

Ages Eligible for Study
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Minimum Age: 15 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Level of functional impairment assessed by the clinician with the FAST scale | We aim to investigate the link between global functioning and decision making abnormalities of patients with eating disorder. The Functioning Assessment Short Test (FAST) is composed of 24 items assessing various dimensions of daily functionning. Each item is ranged from 0 (no difficulty) to 3 (major difficulty) like a likert scale. The FAST is subdivided in 6 subscales : Autonomy (from 0 to 12), Professional activity (from 0 to 15), Cognitive functioning (from 0 to 15), Finances (from 0 to 6), interpersonal relationships (from 0 to 18) and Hobbies (from 0 to 6). The total score is the sum of the 6 subscales from 0 to 72. A hight score reveal hight difficulties in daily functionning | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Decision making assessed by the Iowa Gambling Task | We aim to investigate the link between decision making abnormalities and eating disorder caracteristicus | 1 day | 
| Level of cognitive flexibility assessed by the Brixton test | We aim to investigate the link between cognitive flexibility abnormalities and eating disorder caracteristicus | 1 day | 
| Level of central coherence assessed by the Rey Figure Test | We aim to investigate the link between central coherence abnormalities and eating disorder caracteristicus | 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Anorexia nervosa, Bulimia, Binge eating disorders, Neuropsychology, neurocognition, Daily functioning