Effect of Topical Application of Hyaluronic Acid on Stability of Immediate Loading Dental Implant in Posterior Maxilla

Study Overview
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Brief Summary
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Effect of Topical Application of Hyaluronic Acid on Stability of Immediate Loading Dental Implant in Posterior Maxilla

Detailed Description
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Patients were randomly divided into two groups: Group I (Control group): Ten implants were placed in posterior maxilla and immediately loaded. Group II (Study group): Ten implants were coated with HA before placement in posterior maxilla and immediately loaded.

Official Title
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Effect of Topical Application of Hyaluronic Acid on Stability of Immediate Loading Dental Implant in Posterior Maxilla

Conditions
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Missing Teeth

Intervention / Treatment
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* Other: Hyaluronic acid
* Other: conventional implant placement


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Highly motivated patients with good oral hygiene. Age 18 years or older. Adequate alveolar bone volume at the implant site, at least 6mm in width and 15 mm in height. Free from any parafunctional habits Exclusion Criteria: Patients suffering from any systemic or local disease that contraindicate implant placement or surgery. Pregnancy. Smokers.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Twenty implants were inserted in patients seeking for replacement of missed single or multiple posterior maxillary teeth. Patients were divided randomly into two groups. In the control group, ten implants were placed and immediately loaded. While in the study group, ten implants were coated with hyaluronic acid (HA) immediately before placement and immediately loaded. All patients were clinically evaluated at implant placement time, one, three and six months after loading regarding implant stability. Peri-implant pocket depth and modified sulcus bleeding index were evaluated clinically at six months in all patients. Bone density was evaluated radiographically after three months. All clinical and radiographic data were subjected to statistical analysis.
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: control<br>Each implant was placed into the prepared implant site. | Other: conventional implant placement<br>* immediate placement of dental implant without application of hyaluronic acid on implant surface<br>|
| Experimental: Hyaluronic acid<br>Each implant was placed after topical application of HA on its surface | Other: Hyaluronic acid<br>* immediate placement of dental implant after topical application of hyaluronic acid on implant surface<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| implant stability | using radiofrequency analysis | immediately after surgery | 
| implant stability | using radiofrequency analysis | one month | 
| implant stability | using radiofrequency analysis | three months | 
| implant stability | using radiofrequency analysis | six months | 
| bone density | bone density around the implant is measured in cone beam computed tomography | three months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| propping depth | The distance between the gingival margin and the base of the pocket | six months | 
| bleeding inex | Modified sulcus bleeding index | six months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Hyaluronic Acid, dental implant