Pilot Stair Climbing Study

Study Overview
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Brief Summary
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This pilot study seeks to demonstrate feasibility to conduct data collection and illustrate potential for effect of fractionalized bouts of stair climbing on glucose control in adults at risk for type 2 diabetes.

Detailed Description
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Objective: Compare the short-term effects of two different fractionalized stair climbing bout protocols on glucose control among adults at risk for type 2 diabetes. Rationale: Fractionalized physical activity is associated with reduced BMI, glycated hemoglobin, lower 2-hr plasma glucose and insulin sensitivity in cross-sectional studies. Yet, few studies have examined the effects of fractionalized or intermittent physical activity in a prospective manner. Furthermore, the research is limited to patients with diagnosed type 2 diabetes, or using exercise of a moderate intensity. The hypothesis is that stair climbing, a vigorous-intensity activity, may have a greater health effect. However, this has not been tested in short bouts of activity that are spread out during a day. Implications: Fractionalized physical activity may be more feasible for adults at risk for, or with diagnosed type 2 diabetes who are not currently active. These short bouts can increase energy expenditure throughout the day, rather than in one long continuous bout as currently recommended.

Official Title
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Pilot Study to Test the Effect of Fractionalized Vigorous-Intensity Activity on Acute Glucose in Adults at Risk for Type 2 Diabetes

Conditions
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Prediabetic State

Intervention / Treatment
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* Behavioral: Stair Climbing Frequency


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age greater than 40 years but less than 65 years (working age adult with reduce physiologic capacity to regulate glucose) BMI of overweight or obese (25.0 to 35.0) Answered No to all questions on the Physical Activity Readiness Questionnaire, or has physician approval to participate Hemoglobin A1C% value in the at-risk range of 5.7 to 6.4 Exclusion Criteria: Unable to physically perform stair climbing Currently exercising for 60 or more minutes weekly. Weight over 275 lbs (because stair climbing machine has a weight limit)

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 64 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Stair Climbing 4x/day<br>Participants use the stair climber 4 times per day, for 4 minutes at a time. Total dose = 16 minutes. | Behavioral: Stair Climbing Frequency<br>* Includes 1 sedentary day prior to completing crossover phases.<br>|
| Experimental: Stair Climbing 8x/day<br>Participants use the stair climber 8 times per day, for 2 minutes at a time. Total dose = 16 minutes. | Behavioral: Stair Climbing Frequency<br>* Includes 1 sedentary day prior to completing crossover phases.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Continuous Glucose Monitor | Participant has device inserted prior to dinner the night before the sedentary day, completes the sedentary day and two stair climbing days, then has the device removed on the morning of the 5th day. | Up to 5 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Heart Rate | Measuring heart rate during stair climbing for % max heart rate and % heart rate reserve. Heart rate will be measured during the stair climbing bouts on each of the two intervention days. | 2 Intervention Days |