linjc16/ctgov huggingface dataset:
Turkish Validity and Reliability of the Recovery Scale QoR-15

Study Overview
=================
Brief Summary
-----------------
It is adapted and encouraged to a point to improve their quality of intervention for the purpose of the research.

Detailed Description
-----------------
This research was conducted as a methodological and descriptive study to evaluate the psychometric properties of the Quality of Recovery Score in patients who had surgery. The study was carried out with the participation of 150 patients over the age of 18 who were operated under general anesthesia in Samsun Training and Research Hospital between 8.11.2021 and 3.01.2022.

Official Title
-----------------
Turkish Validity and Reliability of the Recovery Scale QoR-15

Conditions
-----------------
Health Behavior

Intervention / Treatment
-----------------
* Other: Quality of Recovery Score


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: over 18 years operated under general anesthesia Exclusion Criteria: non-operative under general anesthesia under 18 years old

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: single group<br>The Qo0R-15 scale will be administered to 150 patients. | Other: Quality of Recovery Score<br>* Descriptive<br>* Other names: Turkish validity and reliability;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The Turkish validity of the QoR-15 version of the Quality of Healing Scale | questionnaire | 6 mounth |
Manual Therapy in Postoperative Breast Cancer

Study Overview
=================
Brief Summary
-----------------
To evaluate the effectiveness of manual therapy (joint mobilization and massage) combined with kinesiotherapy in women with impaired range of motion after axillary lymph node dissection due to breast cancer regarding the recovery of shoulder range of motion and functionality of the upper limb.

Official Title
-----------------
Manual Therapy in Postoperative Breast Cancer

Conditions
-----------------
Breast Cancer, Axillary Lymph Node Dissection, Shoulder Joint Limitation

Intervention / Treatment
-----------------
* Other: manual therapy, kinesiotherapy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: surgery of breast cancer at University of Campinas axillary lymph node dissection injury of shoulder range of motion Exclusion Criteria: bilateral surgery previous radiotherapy bone metastasis in homolateral upper limb axillary web syndrome

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Manual therapy, kinesiotherapy<br> | Other: manual therapy, kinesiotherapy<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
A Study of Dasatinib in Patients With Imatinib Resistant or Intolerant Chronic Myeloid Leukemia

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate the efficacy and the safety of dasatinib in subject with chronic phase chronic myeloid leukemia(CML) who are either resistant to or intolerant of imatinib mesylate.

Official Title
-----------------
A Phase II Study of Dasatinib in Patients With Imatinib Resistant or Intolerant Chronic Myeloid Leukemia

Conditions
-----------------
Chronic Myeloid Leukemia

Intervention / Treatment
-----------------
* Drug: dasatinib


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Signed Written Informed Consent Subjects with chronic phase chronic myeloid leukemia (CML) Subjects resistant/intolerant to imatinib Subjects presenting: ECOG performance status (PS) score 0-2 Adequate hepatic function Adequate renal function Adequate lung function Exclusion Criteria: Concurrent malignancy other than CML Women who are pregnant or breastfeeding Concurrent pleural effusion Uncontrolled or significant cardiovascular disease A serious uncontrolled medical disorder that would impair the ability of the subjects to receive protocol therapy. Prior therapy with dasatinib Subjects with T315I and/or F317L BCR-ABL point mutations

Ages Eligible for Study
-----------------
Minimum Age: 15 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: dasatinib<br> | Drug: dasatinib<br>* 100mg QD<br>* Other names: BMS-354825;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| rate of Major Molecular Responses (MMR) in chronic phase chronic myeloid leukemia subjects |  | at 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| safety after treatment with dasatinib |  | 2 year | 
| rate of Complete Cytogenetic Response(CCyR) |  | 2 year | 
| rate of Complete Hematologic Response (CHR) |  | 2 year | 
| efficacy on patients with BCR-ABL point mutations |  | 2 year | 
| progression free survival |  | 2 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
chronic myeloid leukemia, dasatinib, chronic phase myeloid leukemia
Pain-related Evoked Potentials in Unilateral Peripheral Nerve Injuries

Study Overview
=================
Brief Summary
-----------------
The study examines pain-related evoked potentials (PREP) in patients with peripheral nerve injuries. Since previous studies found altered latencies and amplitudes of PREP in generalized polyneuropathies, e. g. HIV-polyneuropathy and fibromyalgia, this study investigates if these alterations are detectable in unilateral peripheral nerve injuries as well.

Official Title
-----------------
Evaluation of Pain-related Evoked Potentials (PREP) for the Objectivization of Neuropathic Pain

Conditions
-----------------
Peripheral Nerve Injuries

Intervention / Treatment
-----------------
* Diagnostic Test: Pain-related evoked potentials (PREP)
* Diagnostic Test: Quantitative Sensory Testing (QST)
* Diagnostic Test: Nerve conduction studies (NCS)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Peripheral Nerve Injury Exclusion Criteria: Polyneuropathy Contralateral peripheral nerve injury Severe psychiatric disorders Disorders affecting central nervous system

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients<br>Pain-related evoked potentials (PREP), Quantitative Sensory Testing (QST) and nerve conduction studies (NCS) were performed with patients with peripheral nerve injury. | Diagnostic Test: Pain-related evoked potentials (PREP)<br>* PREP were performed bilaterally with a concentric surface electrode at twice the individual pain threshold.<br>Diagnostic Test: Quantitative Sensory Testing (QST)<br>* QST was performed bilaterally following the protocol of the German Network on Neuropathic Pain.<br>Diagnostic Test: Nerve conduction studies (NCS)<br>* NCS were performed with patients only.<br>|
| Controls<br>Pain-related evoked potentials (PREP) and Quantitative Sensory Testing (QST) were performed with healthy adults. | Diagnostic Test: Pain-related evoked potentials (PREP)<br>* PREP were performed bilaterally with a concentric surface electrode at twice the individual pain threshold.<br>Diagnostic Test: Quantitative Sensory Testing (QST)<br>* QST was performed bilaterally following the protocol of the German Network on Neuropathic Pain.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| N1-latency | N1-latency of pain-related evoked potentials in ms | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| N1P1-amplitude | Amplitude of pain-related evoked potentials in µV | 1 day |
Behav'Robot: Understanding the Surgeon Behavior During Robot-assisted Surgery

Study Overview
=================
Brief Summary
-----------------
Robot-assisted surgery is spreading since the last decade, but little is known about the impact of the use of the robot on surgeon practices and behavior in the operation theatre. Interviewing senior surgeons trained for doing robot-assisted surgery, this qualitative study is expected to provide new insights to understand the surgeons' behavioral changes when using a robot. This study will contribute to improving training programs in robot-assisted surgery.

Official Title
-----------------
Behav'Robot: Understanding the Surgeon Behavior During Robot-assisted Surgery (a Qualitative Study)

Conditions
-----------------
Robotic Surgical Procedures

Intervention / Treatment
-----------------
* Other: Interview


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Senior abdominal and pelvic cavity surgeons (i.e., visceral surgeons, gynecologist surgeons, or urologists). Having completed a robot-assisted training Commonly doing laparoscopic surgery Exclusion Criteria: Those who refuse to participate in the study
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Intervention<br>Senior abdominal and pelvic cavity surgeons (i.e., visceral surgeons, gynecologist surgeons, and urologists) having completed their robot-assisted surgery training, and commonly doing laparoscopic surgery. | Other: Interview<br>* An individual semi-structured interview per surgeon, according to an interview guide.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Elicitation of the surgeons' perception | Elicitation of the surgeons' perception of practices and behavior changes when doing robot-assisted surgery. | = interview duration (about 30 minutes) |
Comparing Different Ways of Delivering Humidity to Children With Croup

Study Overview
=================
Brief Summary
-----------------
Croup affects 5% of children under 6 years of age, resulting in visits to hospital Emergency Departments, and in 1% of children, hospitalization. Traditionally, the first therapy offered is humidification which can liquify airway secretions and decrease airway swelling. This study will compare the effectivenesss of 40% and 100% humidity through a specially designed machine called a nebulizer, with the usual humidity set-up (blown into the patient's face from a hose).

Official Title
-----------------
Efficacy of Optimal Versus 'Traditional' Delivery of Humidity in Children With Croup

Conditions
-----------------
Croup

Intervention / Treatment
-----------------
* Device: nebulized humidity


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: children aged 3 months - 10 years croup score greater than or equal to 2 after a 30 minute waiting period Exclusion Criteria: Symptoms of croup requiring immediate intervention with nebulized epinephrine or intubation symptoms or signs of alternative causes of stridor inability of caregivers to understand or speak English and/or sign for informed consent history of chronic pulmonary disease except for asthma, or co-existent systemic disease previous history of intubation duration of present illness >1 week systemic or inhaled glucocorticoids in previous 48 hours epinephrine in previous 4 hours

Ages Eligible for Study
-----------------
Minimum Age: 3 Months
Maximum Age: 10 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: nebulized humidity|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| changes in the croup score from baseline to 30 and 60 minutes |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| steroid or epinephrine treatment at 60 minutes |  |  | 
| discharge rate at 60 minutes |  |  | 
| change in pulse, respiratory rate, and oxygen saturation at 60 minutes |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
croup, humidity therapy, pediatrics
Comparison of Gated Blood-pool SPECT and Echocardiogram for Ventricular Function

Study Overview
=================
Brief Summary
-----------------
To compare the calculated biventricular ejection fraction from cadmium-zinc-telluride (CZT) single photon emission computed tomography (SPECT) with planar equilibrium radionuclide angiography (ERNA), first-pass radionuclide ventriculography (FP-RNV) and echocardiogram.

Detailed Description
-----------------
To evaluate the feasibility of using CZT SPECT as an all-in-one technique to provide information on both left ventricular ejection fraction (LVEF) and right ventricular ejection fraction (RVEF) derived from a single examination and compare with the values from traditional planar ERNA, FP-RNV and echocardiography.

Official Title
-----------------
Comparison of Gated Blood-pool SPECT Using CZT Camera and Echocardiogram for Ventricular Ejection Fraction Estimation

Conditions
-----------------
Ventricular Dysfunction

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients underwent transthoracic echocardiogram and resting cardiac function within interval of 90 days of each other Exclusion Criteria: Pregnancy

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measure the biventricular ejection fraction |  | Through study completion, an average of 3 years |
Diffusion of Local Anesthetic After Median Nerve Block

Study Overview
=================
Brief Summary
-----------------
Median nerve block is widely practised, avoiding general anaesthesia in a number of cases and producing excellent post-operative analgesia in orthopedic surgery. Even realised by experienced anaesthetists,a failure rate of 5-15% is noticed. The principal aim of the study is to observe the local anesthetic solution diffusion after a conventional median nerve block technique using neurostimulation. The secondary objective is to compare diffusion and of block efficacy..

Official Title
-----------------
Can Ultrasound Predict Success of Median Nerve Block? Relationship Between Diffusion of Local Anesthetic and Effectiveness of a Nerve Block

Conditions
-----------------
Median Nerve

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients undergoing elective hand surgery requiring a median block nerve. Exclusion Criteria: age lower than 18 years pregnancy contraindication to nerve block inability to read, write or speak French mental illness.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Anesthesic diffusion degree |  | 1 hour | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Median block nerve, Ultrasound
Prognostic Relevance of Biological Subtype in Breast Cancer

Study Overview
=================
Brief Summary
-----------------
Recently, the investigators face on the edges for treatment decision to decide adjuvant systemic treatment, especially for patients who show discordance between stage and tumor biology. The aim of this study was to compare the prognostic relevance of the TNM staging system and intrinsic subtype in breast cancer patients who received curative surgery.

Detailed Description
-----------------
Identified patients who received curative surgery for stage I-III breast cancer and had available data on immunohistochemistry profiles including hormone receptor status (HR) status, human epidermal growth factor receptor 2 (HER2) status, and Ki 67 staining at Samsung Medical Center from January 2004 to September 2008. Primary outcomes were recurrence-free survival (RFS) and overall survival (OS).

Official Title
-----------------
Prognostic Relevance of Biological Subtype Overrides That of TNM Staging in Breast Cancer: Discordance Between Stage and Biology

Conditions
-----------------
Breast Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients who received curative surgery stage I-III breast cancer between January 2004 and September 2008 had available immunohistochemistry profiles. exclusion Criteria: age <18 years old microinvasive carcinoma of breast

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Breast cancer stage I-III<br>who received curative surgery for stage I-III breast cancer and had available data on immunohistochemistry profiles including hormone receptor status (HR) status, human epidermal growth factor receptor 2 (HER2) status, and Ki 67 staining at Samsung Medical Center from January 2004 to September 2008. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overall survival | was measured from the first date of diagnosis of breast cancer to the date of death or the last follow-up visit | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Recurrence-free survival | was defined as the time from the date of curative resection to the date when breast cancer recurred, irrespective of locoregional recurrences including ipsilateral and contralateral breast recurrences or distant metastases. | 1 Year |
Effect of Bariatric Surgery on Cognition, Genetics and Lifestyle

Study Overview
=================
Brief Summary
-----------------
Obesity bariatric surgery patients usually lose more than 50% of their former obesity within a relatively short time (  2 years). There is still a lack of knowledge about underlying psychological and biological mechanisms of decline in body weight. The intention of this project is to investigate whether bariatric surgery is associated with patients' cognitive ability, lifestyle and/or gene expression and metabolomics.

Official Title
-----------------
Effect of Bariatric Surgery on Cognition, Genetics and Lifestyle

Conditions
-----------------
Obesity, Morbid

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: First bariatric surgery Exclusion Criteria: More than one surgery

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in gene expression profile (a.o. FTO, BDNF) following a standardized meal (before vs. after surgery) | Gene expression profiling (whole genome analysis, with first interest in FTO and BDNF expression) to assess changes in gene expression before vs. after surgery, and to associate gene expression with weight loss after surgery | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The effect of bariatric surgery on cognitive functioning (inhibitory control, selective attention) | No-Go go task (to assess inhibitory control) and Stroop tasks (to assess selective attention) will be measured to assess change in these cognitive functions before vs. after surgery, and to associate cognitive functioning with weight loss after surgery | Measures 1 y, 2 y, and 5 y after surgery. | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Bariatric surgery, Cognitive function, Gene expression, Metabolomics, Obesity, Overweight, Lifestyle