Conatumumab, Gemcitabine Hydrochloride, Capecitabine, and Radiation Therapy in Treating Patients With Locally Advanced Pancreatic Cancer

Study Overview
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Brief Summary
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RATIONALE: Monoclonal antibodies, such as conatumumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Drugs used in chemotherapy, such as gemcitabine hydrochloride and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy may uses high energy x-rays to kill tumor cells. Giving conatumumab together with gemcitabine hydrochloride, capecitabine, and radiation therapy may kill more tumor cells. PURPOSE: This phase I/II trial is studying the side effects and best dose of conatumumab when given together with gemcitabine hydrochloride, capecitabine, and radiation therapy and to see how well they work in treating patients with locally advanced pancreatic cancer.

Detailed Description
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OBJECTIVES: Primary To evaluate the maximum tolerated dose of conatumumab up to a target dose of 10 mg/kg given concurrently with capecitabine and radiotherapy following induction therapy comprising conatumumab and gemcitabine hydrochloride in patients with locally advanced pancreatic cancer. (Phase I) To evaluate the overall survival of patients treated with this regimen. (Phase II) Secondary To evaluate the safety profile in patients treated with this regimen. (Phase I and II) To evaluate the progression-free survival of patients treated with this regimen. (Phase II) To evaluate the primary tumor response rate in patients treated with this regimen. (Phase II) To generate translational research hypotheses. (Phase II) OUTLINE: This is a multicenter, phase I dose-escalation study of conatumumab, followed by a phase II study. Induction therapy: Patients receive conatumumab IV over 30-60 minutes on days 1 and 15 and gemcitabine hydrochloride IV over 30 minutes on days 1, 8, and 15. Treatment repeats every 28 days for 2 courses. Conatumumab and chemoradiotherapy: Beginning 14-42 days after the last course of induction therapy, patients undergo 3-dimensional radiotherapy once daily, 5 days a week, for 5½ weeks (28 treatments). Patients also receive conatumumab IV over 30-60 minutes on days 1, 15, and 29 and oral capecitabine twice daily, 5 days a week, for 5½ weeks. Maintenance therapy: Beginning 28-56 days after completion of chemoradiotherapy, patients receive conatumumab IV over 30-60 minutes on days 1 and 15 and gemcitabine hydrochloride IV over 30 minutes on days 1, 8, and 15. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed up periodically.

Official Title
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A Phase I/II Study of Induction Conatumumab and Gemcitabine, Followed by Conatumumab, Capecitabine and 3-D Conformal Radiation Therapy (3D-CRT) With Subsequent Maintenance Therapy for Locally Advanced Pancreatic Cancer

Conditions
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Pancreatic Cancer

Intervention / Treatment
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* Biological: conatumumab
* Drug: capecitabine
* Drug: gemcitabine hydrochloride
* Radiation: 3-dimensional conformal radiation therapy


Participation Criteria
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Eligibility Criteria
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DISEASE CHARACTERISTICS: Histologically or cytologically confirmed adenocarcinoma of the pancreas Locally advanced disease With and without regional adenopathy Unresectable disease based on institutional standardized criteria of unresectability OR medically inoperable No distant metastatic disease, second malignancy, or peritoneal seeding PATIENT CHARACTERISTICS: Zubrod performance status 0-1 Absolute granulocyte count ≥ 1,500/mm³ Platelet count ≥ 100,000/mm³ Hemoglobin ≥ 8.0 g/dL (transfusion or other intervention allowed) Serum creatinine ≤ 1.5 mg/dL ALT or AST < 3 times upper limit of normal (ULN) Total bilirubin < 3.0 mg/dL Alkaline phosphatase < 3 times ULN Amylase ≤ 2 times ULN Lipase ≤ 2 times ULN Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception during and for ≥ 3 months after the last study drug administration (for women) or for ≥ 6 months after the last study drug administration (for men) Able to swallow oral medications No other invasive malignancy within the past 2 years, except for nonmelanomatous skin cancer or carcinoma in situ of the breast, oral cavity, or cervix No severe, active co-morbidity, including any of the following: Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy within the past 30 days Transmural myocardial infarction within the past 3 months Unstable angina and/or congestive heart failure requiring hospitalization within the past 6 months Any other cardiac condition that, in the opinion of the treating physician, would make study treatment unreasonably hazardous for the patient Acute bacterial or fungal infection requiring IV antibiotics Uncontrolled malabsorption syndrome significantly affecting gastrointestinal function Any unresolved bowel or bile duct obstruction Major resection of the stomach or small bowel that could affect the absorption of capecitabine AIDS based upon current CDC definition HIV testing is not required for study entry No prior allergic reaction to capecitabine or gemcitabine hydrochloride PRIOR CONCURRENT THERAPY: No prior radiotherapy to the region of the study cancer that would result in overlap of radiotherapy fields No prior treatment with TRAIL-receptor agonists No prior systemic chemotherapy for pancreatic cancer More than 2 years since prior chemotherapy for malignancies other than pancreatic cancer More than 28 days since prior major surgery (e.g., biliary or gastric bypass) Insertion of a vascular access device, exploratory laparotomy, or laparoscopy are not considered major surgery No concurrent intensity-modulated radiotherapy No other concurrent chemotherapy No other concurrent monoclonal antibody therapy No concurrent sorivudine, brivudine A, or cimetidine No concurrent participation in another clinical trial Concurrent oral anticoagulants (e.g., warfarin) allowed provided INR is monitored

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Biological: conatumumab|nan|
|Drug: capecitabine|nan|
|Drug: gemcitabine hydrochloride|nan|
|Radiation: 3-dimensional conformal radiation therapy|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Dose-limiting toxicity (Phase I) |  |  | 
| Overall survival (Phase II) |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Adverse events (Phase I and II) |  |  | 
| Progression-free survival (Phase II) |  |  | 
| Response rate (Phase II) |  |  | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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adenocarcinoma of the pancreas, stage III pancreatic cancer