Impact of Age at Conization on Obstetrical Outcome: A Case-Control Study

Study Overview
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Brief Summary
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The maternity ward attached to the colposcopy clinic was also the obstetrical referral center for the region and carried out approximately 2500 deliveries per year. The aim of the study was to assess whether an age younger than 25 years at conization affected future pregnancy outcome as an independent factor. A retrospective study of 115 women who underwent both loop electrosurgical excision procedure (LEEP) and subsequent pregnancy follow-up in a referral center was conducted. Two groups were considered: patients younger than 25 years at the time of the loop electrosurgical excision procedure (n = 42) and 25 years or older (n = 73). Analyzed data were occurrence of preterm adverse obstetrical event and, specifically, preterm labor (PL) and preterm rupture of membranes; stratification based on term of occurrence was performed: less than 37 weeks of amenorrhea (WA), less than 34 WA, and less than 26 WA.

Detailed Description
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The investigators conducted a retrospective observational study between January 2008 and December 2015 in a French colposcopic referral academic hospital. The maternity ward attached to the colposcopy clinic was also the obstetrical referral center for the region and carried out approximately 2500 deliveries per year. The aim of the study was to assess whether an age younger than 25 years at conization affected future pregnancy outcome as an independent factor. A retrospective study of 115 women who underwent both loop electrosurgical excision procedure (LEEP) and subsequent pregnancy follow-up in a referral center was conducted. Two groups were considered: patients younger than 25 years at the time of the loop electrosurgical excision procedure (n = 42) and 25 years or older (n = 73). Analyzed data were occurrence of preterm adverse obstetrical event and, specifically, preterm labor (PL) and preterm rupture of membranes; stratification based on term of occurrence was performed: less than 37 weeks of amenorrhea (WA), less than 34 WA, and less than 26 WA.

Official Title
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Impact of Age at Conization on Obstetrical Outcome: A Case-Control Study

Conditions
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Pregnancy Complications

Intervention / Treatment
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* Other: loop electrosurgical excision procedure


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: female pregnant underwent loop electrosurgical excision procedure during the studied period delivered in their institution Exclusion Criteria: patients having delivered elsewhere after loop electrosurgical excision procedure Early miscarriages (<14 weeks of amenorrhea )

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| < 25 years<br>42 patients younger than 25 years at the time of loop electrosurgical excision procedure | Other: loop electrosurgical excision procedure<br>* A retrospective study of 115 women who underwent both loop electrosurgical excision procedure (LEEP) and subse- quent pregnancy follow-up in a referral center was conducted.<br>|
| > 25 years<br>73 patients 25 years or older at the time of loop electrosurgical excision procedure | Other: loop electrosurgical excision procedure<br>* A retrospective study of 115 women who underwent both loop electrosurgical excision procedure (LEEP) and subse- quent pregnancy follow-up in a referral center was conducted.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| occurrence of preterm adverse obstetrical event in the group of women younger than < 25 years old | The objective of this study was to evaluate if an age younger than < 25 years old at the time of loop electrosurgical excision procedure affected future pregnancy and can have impact on th early preterm adverse obstetrical events. | 18 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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LEEP, preterm labor