linjc16/ctgov huggingface dataset:
Influence of Socket Volume on Prosthesis Performance

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to investigate how residual limb fluid volume, gait, prosthesis use, perceived comfort, and satisfaction with the prosthesis are affected by size of the prosthetic socket. Subjects are tested after wearing a nominal socket for 1 month and again after wearing a slightly oversized socket for 1 month.

Official Title
-----------------
Influence of Socket Volume on Prosthesis Performance

Conditions
-----------------
Lower Limb Amputation Below Knee (Injury)

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: transtibial amputee at least 18 months post amputation over 18 years of age capable of treadmill walking and 90 seconds of continuous standing Exclusion Criteria: skin breakdown on the residual limb

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Transtibial amputees<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Residual limb fluid volume |  | 1 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Activity |  | 1 month | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
prosthetic socket, amputee
Comparison of Choosing Free ALT or Free PMT for Reconstruction With Head and Neck Cancer

Study Overview
=================
Brief Summary
-----------------
This study was designed to compare the outcome of the anteromedial thigh (AMT) and anterolateral thigh (ALT) flaps in head and neck cancer reconstruction.

Detailed Description
-----------------
To compare the results of the AMT and ALT flaps, this study aimed to compare their outcomes in head and neck cancer reconstruction under the condition of attenuating baseline patient and operative characteristics with the selection of propensity score-matched patient cohorts.

Official Title
-----------------
Comparison of the Outcome of Choosing Free Anterolateral Thigh or Free Posterolateral Thigh Flap for Reconstruction in Patients With Head and Neck Cancer

Conditions
-----------------
Reconstructive Surgery, Head and Neck Cancer

Intervention / Treatment
-----------------
* Other: ALT flap reconstruction
* Other: AMT flap reconstruction


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients who underwent ALT or AMT free flap reconstruction after head and neck cancer surgery between March 1, 2008 and February 28, 2017. Exclusion Criteria: Patients whose data were missing will be excluded.

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 100 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| ALT&AMT free flap reconstruction<br>Patients who underwent ALT or AMT free flap reconstruction after head and neck cancer surgery between March 1, 2008 and February 28, 2017 | Other: ALT flap reconstruction<br>* Patients who underwent ALT free flap reconstruction after head and neck cancer surgery.<br>Other: AMT flap reconstruction<br>* Patients who underwent AMT free flap reconstruction after head and neck cancer surgery.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| survival or failure | The primary free flap outcome was determined as its survival or failure. | up to 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Complications | The second outcome was the associated complications (fistula, hematoma, partial necrosis, and wound infection). | up to 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Anterolateral thigh (ALT), anteromedial thigh (AMT), free flap reconstruction, microsurgery, head and neck cancer, outcomes
Sleep, Circadian Rhythms and Cluster Headache

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to assess both the sleep and circadian (24-hourly biological rhythms) physiology of people with cluster headache. For sufferers with the episodic form of the disorder this will involve observation at two separate time points, once when experiencing attacks (in-bout) and once when attack free (out-of-bout). The study will include measurement of basic rest-activity patterns, sleep timing and timing of individual attacks, as well as a more detailed study recording sleep and circadian rhythms under clinical conditions over consecutive nights. Studying the differences in these processes in single individuals when they are both experiencing and free from attacks might provide insight into the brain mechanisms involved in triggering the bouts of attacks and individual attacks themselves. An improved understanding of this area may help design improved treatment options in future.

Official Title
-----------------
Characterisation of Sleep and Circadian Physiology in Individuals With Cluster Headache

Conditions
-----------------
Cluster Headache

Intervention / Treatment
-----------------
* Other: Polysomnography
* Other: Actigraphy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosis of cluster headache or closely related primary headache disorder Exclusion Criteria: Abnormality on screening investigations that increase risk of participation Alcohol consumption exceeding 21 units per week

Ages Eligible for Study
-----------------
Minimum Age: 16 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cluster headache<br>Cluster headache sufferers (both chronic and episodic) | Other: Polysomnography<br>* Overnight physiological recording of sleep<br>Other: Actigraphy<br>* Wristwatch activity to measure basic rest activity cycle and sleep efficiency<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| amplitude and phase of circadian rhythm of melatonin |  | 36 hours | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Cluster Headache, Trigeminal Autonomic Cephalalgias, Sleep, Circadian Rhythms
Telomeres Parameters in Celiac Disease

Study Overview
=================
Brief Summary
-----------------
Celiac disease is an autoimmune process that causes destructive changes in the epithel of the small bowel and it is also a pre-malignant state (e.g lymphoma). The aim of the study is to examine telomere length and other parameters of genetic instability from peripheral blood lymphocytes of patients with celiac disease compared with healthy controls.

Conditions
-----------------
Celiac Disease

Intervention / Treatment
-----------------
* Procedure: take blood samples


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients with celiac disease Exclusion Criteria: known malignancy cannot sign informed consent under age 18

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Intervention Model: Parallel Assignment


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: celiac disease<br> | Procedure: take blood samples<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| telomere length |  | at entry, after 6 months of gluten-free diet | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
celiac, telomere, telomerase
Functional Prognosis of Post-operative Patients With Cerebral Small Vascular Disease(CSVD)

Study Overview
=================
Brief Summary
-----------------
The investigators perform a retro-prospective exploratory cohort study among patients 65 to 85 years old with pre-operative head MRI result after thoracic surgery in Renji Hospital Affiliated to Shanghai Jiaotong University from November 2020 to December 2021. Perioperative data were collected, including preoperative general condition, laboratory examination, auxiliary examination (blood routine, blood coagulation, liver and kidney function, etc.), perioperative indicators （use of anesthetics, anesthetic time, blood pressure, etc.）, postoperative cerebral function follow-up and occurrence of cerebral vascular complications (brain infarction, brain bleed, etc.) of patients.

Official Title
-----------------
Association Between Postoperative Cerebral Vascular Complication and Functional Prognosis and Cerebral Small Vascular Disease (CSVD) After Thoracic Surgery : an Exploratory Study

Conditions
-----------------
Cerebral Small Vessel Diseases, Long Term Adverse Effects

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 65≤age<85 after thoracic surgery finish pre-operative brain MRI Exclusion Criteria: mental illness existing dementia and other diseases: Alzheimer disease, dementia, Parkinson's disease, Huntington's disease, systemic lupus erythematosus, etc. previous cerebral infarction or hemorrhage

Ages Eligible for Study
-----------------
Minimum Age: 65 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of postoperative overt stroke | Postoperative overt stroke detected by MRI of the brain | 1 year after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Physical function after surgery as assessed using Activities of Daily Living (iADL) Scale | score of Activity of Daily Living Scale with total score of 78, higher score, better function) and Modified Ranking Scale from 0(no symptomatic post-infarction complication ) to 6 (death after cerebral infaction) | 1 year after surgery | 
| Physical function after surgery as assessed using the Modified Rankin Scale | The scale runs from 0-6, running from perfect health without symptoms to death. A higher score is worse. | 1 year after surgery |
Dutch Sub Study: Controlled Rosuvastatin Multinational Study in Heart Failure (CORONA). PET Sub Study

Study Overview
=================
Brief Summary
-----------------
At one site, patients participating in the Corona main study are asked to participate in the PET-substudy. Before and 6 months after study medication is started a Positron Emission Tomography (PET-scan) is performed to study the effect of rosuvastatin in Chronic Heart Failure on myocardial perfusion (reserve)

Official Title
-----------------
Sub Study: Controlled Rosuvastatin Multinational Study in Heart Failure (CORONA) PET Sub Study

Conditions
-----------------
Rosuvastatin, Heart Failure, Positron Emission Tomography (PET)

Intervention / Treatment
-----------------
* Drug: Rosuvastatin
* Procedure: Positron emission tomography


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients fulfilling the in and exclusion criteria of the CORONA study and separate informed consent for participation in the sub study. Exclusion Criteria: See above

Ages Eligible for Study
-----------------
Minimum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Rosuvastatin|nan|
|Procedure: Positron emission tomography|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To study the effect of rosuvastatin in Chronic Heart Failure on myocardial perfusion (reserve). Before and 6 months after study medication is started a Positron Emission Tomography (PET-scan) is performed. |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To study the effect of rosuvastatin in Chronic Heart Failure on mismatch. Before and 6 months after study medication is started a Positron Emission Tomography (PET-scan) is performed. |  |  |
Minimally-Invasive Cardiovascular Hemodynamic Optimization (MiCHO) Versus Early Goal-Directed Therapy (EGDT) in the Management of Septic Shock

Study Overview
=================
Brief Summary
-----------------
Early intervention in the treatment of septic shock, including early goal-directed therapy (EGDT) in the first 6 hours of disease presentation, has been shown to significantly decrease mortality. However, this approach requires invasive hemodynamic monitoring, thus limiting its widespread application in the emergency department setting. A minimally invasive protocol utilizing esophageal Doppler monitoring (EDM) may be of benefit and practical if it is shown to result in similar outcome as EGDT.

Official Title
-----------------
A Multi-center Randomized Comparison of a Minimally-invasive Cardiovascular Hemodynamic Optimization (MiCHO) Protocol Versus Early Goal-Directed Therapy (EGDT) in the Management of Septic Shock Patients Presenting to the Emergency Department

Conditions
-----------------
Severe Sepsis, Septic Shock

Intervention / Treatment
-----------------
* Device: Esophageal Doppler monitoring - CardioQ, Deltex Inc
* Device: Central line with CVP and continuous ScvO2 monitoring


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adult patients >= 18 years old Source of infection Two or more of systemic inflammatory response syndrome criteria Systolic blood pressure < 90 mmHg after a fluid bolus OR lactate >= 4 mmol/L A central line has been placed for CVP/ScvO2 monitoring Exclusion Criteria: Pregnancy Acute stroke Acute cardiogenic pulmonary edema Status asthmaticus Unstable cardiac dysrhythmia Active hemorrhage Acute seizure Drug overdose Trauma Requiring immediate surgery Do-not-resuscitate status

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: MiCHO<br>A 6-hour resuscitation protocol utilizing the esophageal Doppler monitoring (EDM) | Device: Esophageal Doppler monitoring - CardioQ, Deltex Inc<br>* 6-hour hemodynamic optimization of severe sepsis or septic shock guided by EDM<br>|
| Active Comparator: EGDT<br>A 6-hour resuscitation protocol utilizing CVP/ScvO2 | Device: Central line with CVP and continuous ScvO2 monitoring<br>* 6-hour hemodynamic optimization of severe sepsis or septic shock guided by CVP and ScvO2 monitoring<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality | In-hospital mortality | hospital | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Emergency Department, Hemodynamic Optimization, Esophageal Doppler monitoring, Early Goal-Directed Therapy
Clinical Study of the Presence of Trichomonas Tenax and Entamoeba Gingivalis in Patients With Periodontitis

Study Overview
=================
Brief Summary
-----------------
The buccal cavity presents microorganismes whose the number and composition vary with oral hygiene and medical context (pathologies and associated drug therapies) of the patient. More than 1200 bacterial species have been identified, and among them, 400 are inhabitants of the sub-gingival biofilm. Among all these microorganismes, only 20 species participate to the etiopathogenesis of periodontal diseases.Some are recognised as major periodontopathogens other play unclear role in this pathology. They belong respectively to the red and orange complex of Socransky et al. (1998). Other microorganismes such as virures, yeasts and protozoans could potentially impact the emergence and development of periodontal diseases. The presence of protozoans in periodontitis have been investigated in this study.

Official Title
-----------------
Preliminary Clinical Study of the Presence of Trichomonas Tenax and Entamoeba Gingivalis in Patients With Periodontitis Consulting to CHU of Nancy, in Periodontal Department.

Conditions
-----------------
Periodontitis, Adult

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adults > 18 years-old Consulting in periodontal department of CHU, Nancy Patient with moderate to severe periodontitis At least 2 periodontal sites with PPD≥ 4mm and One healthy site No scaling root planning in the last 6 months Patients insured under the French social security system Exclusion Criteria: Pregnant patients Patients with antibiotic therapy, and/or all medecines which could modify the buccal microbiota in the last 6 months Tooth with endodontic periapical lesion Patients having a scaling root planning in the last 6 months Patient with guardianship

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Presence of protozoans |  | baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Periodontal pocket depth (mm) |  | baseline | 
| Clinical attachment loss (mm) |  | baseline | 
| Plaque and gingival index |  | baseline | 
| Mobility of the tooth (Yes/No) |  | baseline | 
| Presence of bleeding on probing (Yes/No) |  | baseline |
Validation of the Stockholm3 Test for Detection of Prostate Cancer in the Swiss Population

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to collect blood samples to investigate the prognostic performance of the STHLM3 test in a population of Swiss and German men suspected of harbouring prostate cancer based on a combination of elevated PSA levels (e.g. >2.5 ng/ml) and/or pathological digital rectal examination and/or MRI-findings.

Official Title
-----------------
Validation of the Prostate Cancer Biomarker Stockholm3 for Improved Disease Detection and Classification in the Swiss Population

Conditions
-----------------
Prostate Cancer, Localized Carcinoma

Intervention / Treatment
-----------------
* Diagnostic Test: Stockholm3


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Planned prostate biopsy due to suspicion of prostate cancer (usually due to a combination of elevated PSA levels [e.g. >2.5 ng/ml] and/or pathological digital rectal examination and/or MRI-findings) Written informed consent by the participant Exclusion Criteria: Severe anemia (Hb <60g/l) Previously already established diagnosis of prostate cancer.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 99 Years

Sexes Eligible for Study
-----------------
Male

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: Stockholm3|Stockholm3 test prior to prostate biopsy. Prostate biopsy is preformed irrespective of the Stockholm3 score.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cancer detection | Correlation between Stockholm3 and histological diagnosis of prostate cancer | 2020-2022 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Disease state | Correlation between Stockholm3 and clinical disease stage | 2020-2022 |
Respiratory Measurement Using Infrared Camera and Respiratory Volume Monitor (ExSpiron 1Xi) for Sedation in Patients Undergoing TURP/TURB Under Spinal Anesthesia

Study Overview
=================
Brief Summary
-----------------
In patients undergoing spinal anesthesia, the investigators used an Infra-red camera and a respiratory volume monitor to determine the accuracy of the ventilation rate of the infra red camera by measuring the respiratory rate, ventilation volume, and ventilation volume with respiratory volume monitor.

Official Title
-----------------
Respiratory Measurement Using Infrared Camera and Respiratory Volume Monitor (ExSpiron 1Xi) for Sedation in Patients Undergoing TURP/TURB Under Spinal Anesthesia

Conditions
-----------------
Prostate Cancer, Bladder Cancer

Intervention / Treatment
-----------------
* Device: Infrared camera
* Device: RVM(Respiratory Volume Monitor)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: An adult male who underwent endoscopic prostatectomy resection with regular surgery An adult male who underwent endoscopic bladder resection with regular surgery Exclusion Criteria: Presenting alteration in respiratory function detected by functional analysis of lung volume and capacity- pneumonectomy patient, severe ipsilateral destroyed lung patient Inability to understand or perform the procedure ASA(American Society of Anesthesiologists) class 4,5

Ages Eligible for Study
-----------------
Minimum Age: 19 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Respiratory monitoring group<br> | Device: Infrared camera<br>* In patients undergoing spinal anesthesia, the respiratory parameters are measured using an Infrared camera.<br>Device: RVM(Respiratory Volume Monitor)<br>* In patients undergoing spinal anesthesia, the respiratory parameters are measured using an RVM(Respiratory Volume Monitor).<br>* Other names: ExSpiron™ 1Xi;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The accuracy of breathing measurements | The accuracy of breathing measurements between infrared camera and RVM in patients with spinal anesthesia | Intraoperative period about 1 hour |