Frontal Lobe Oxyhemoglobin Levels in Patients With Lower Extremity Burns Assessed Using a fNIRS

Study Overview
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Brief Summary
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Investigators investigate the patterns of cortical activation using the NIRST in patients with peripheral neurological injury caused by lower extremity burns.

Detailed Description
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Understanding the mechanisms associated with locomotor networks may be of benefit for rehabilitation of burn victims with neurological locomotor deficits. However, the effects of peripheral neurological injury on locomotor network remains unknown. A wearable functional near-infrared spectroscopy (fNIRS) device has been developed for studying cortical hemodynamics. Changes in cortical activity has not previously been documented in patients with burn injury. Investigators assessed 15 patients with lower extremity burns and 11 healthy controls. Investigators measured walking-related cortical activity using an fNIRS device at baseline and during usual walking. Cortical activity was measured by evaluating relative changes in oxyhemoglobin level. The NIRST Analysis Tool v2.1 was utilized to analyze fNIRS data in a MATLAB environment.

Official Title
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Frontal Lobe Oxyhemoglobin Levels in Patients With Lower Extremity Burns Assessed Using a Functional Near-Infrared Spectroscopy Device During Usual Walking: A Pilot Study

Conditions
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Walking

Intervention / Treatment
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* Diagnostic Test: Functional near-infrared spectroscopy (fNIRS)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: burn patients with lower extremity or upper extremity thermal injury patients who could walk unassisted for at least 5min. Exclusion Criteria: patients with critical systemic conditions severe cognitive impairment had severe pain unable to walk.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Interventional Model Description: patients with lower extremity burn : 15 patients patients with upper extremity burn : 10 patients healthy controls : 11
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: burn injury and normal patient<br>HbO2 PFC perfusion using fNIRS | Diagnostic Test: Functional near-infrared spectroscopy (fNIRS)<br>* Functional near-infrared spectroscopy (fNIRS) measurement<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| oxygenated hemoglobin (HbO2) of the prefrontal regions, | identify the location of the normal cortical activation during usual walking | 5 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Burn, Near-infrared spectroscopy (NIRS)