Analysis of the Pachychoroid Phenotype in an Asian Population

Study Overview
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Brief Summary
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The understanding of pachychoroid phenotype is incomplete. It is important to understand the risk of conversion from an uncomplicated pachychoroid phenotype to the pachychoroid disease phenotype, to guide appropriate management of these patients.

Detailed Description
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The progression of uncomplicated pachychoroid phenotype to pachychoroid disease is not well established and the pathophysiology of these phenotypes remains unknown: specifically if the occurence of pachyvessels is the primary event, or develops secondary to the inner choroidal attenuation. A longitudinal study of the pachychoroid phenotype will provide much needed information regarding the natural history of the pachychoroid phenotype. Secondly, a detailed chronicle of the choroidal alterations in the pachychoroid disease spectrum may yield insights into the pathogenesis, and facilitate the development of disease modulation strategies.

Official Title
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Analysis of the Pachychoroid Phenotype in an Asian Population

Conditions
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Pachychoroid Disease

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Presence of uncomplicated and/or non-neovascular pachychoroid phenotype in at least one eye. Subfoveal choroidal thickness >300 microns on enhanced depth imaging optical coherence tomography for at least one eye Male or female patients above 45 years of age Willingness to undergo pupil dilation, and protocol- required procedures for both eyes Willing to provide written informed consent Exclusion Criteria: Presence of disorders of the ocular media which interfere with visual acuity and other ocular assessments, including Spectral domain- optical coherence tomography during the study period Pregnant or nursing women

Ages Eligible for Study
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Minimum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of progression of pachychoroid phenotypes in 2 subtypes | Two subtypes of pachychoroid phenotypes: from an uncomplicated pachychoroid phenotype, to a pachychoroid disease entity from non neo-vascular pachychoroid disease, to neovascular pachychoroid disease | 2 years observation | 
| Risk factors for progression in 2 subtypes of pachychoroid phenotypes | from an uncomplicated pachychoroid phenotype, to a pachychoroidal disease entity from neo-vascular pachychoroid disease, to neovascular pachychoroid disease | 2 years | 
| Assess the chronology of choroidal changes in patients | Determine the occurence of pachyvessles is the primary event, or consequent to inner choroidal attenuation | 2 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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pachychoroid neovasculopathy, pachychoroid choroidal vasculopathy