Cognitive Disorders and Brain Pulse

Study Overview
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Brief Summary
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Following an initial consultation with a memory, resources and research centre (MRRC) doctor, a day hospital may be prescribed to carry out an assessment of cognitive disorders. Patients are then usually followed up in consultation at least once a year, in the framework of a new day hospital and/or consultations with a MRRC doctor.

Detailed Description
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Patients will be included at the time of the day hospital assessment. All patients received in the day hospital of the MRRC of Tours will be offered the TPI examination. The patients included will be followed up for a period of 5 years and the TPI examination will be repeated according to the same modalities, as part of their follow-up at the MRRC and/or in the context of a new day hospital if necessary.

Official Title
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Cognitive Disorders and Brain Pulse

Conditions
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Neurocognitive Disorders

Intervention / Treatment
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* Other: Ultrasound examination


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient benefiting from a day hospital at the MRRC of the CHU of Tours for assessment of cognitive functions Exclusion Criteria: Refusal of TPI ultrasound examination Patients who opposed to data processing Patients under judicial protection
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| assessment of cognitive functions<br>Assessment of cognitive disorders with an ultrasound examination performed in routine care during a day hospital. | Other: Ultrasound examination<br>* Ultrasound examination with Tissue Pulsatility Imaging (TPI) TPI is a relatively simple, rapid and non-invasive ultrasound examination which consists of applying a standard ultrasound probe to the acoustic window of the temporal bone to first measure the velocity of the middle cerebral artery in Doppler mode and secondly the cerebral pulsatility (CP) of a region of approximately 10cm2 centred on the middle cerebral artery in B-Echo mode. After collecting the information, the TPI examination will be performed by MRRC staff specially trained in TPI by engineers. The duration of the examination is between 20 and 30 minutes, including hardware installation. Four 30-second PC acquisitions will be collected per examination, with the patient lying supine on the bed in the day hospital room, then one measurement every minute for 3 minutes after standing.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| maximum amplitude of brain movements | Measurement by ultrasound between patients with Minor Neurocognitive Disorders (mNCD) and Major Neurocognitive Disorders (MNCD). | one a year from inclusion visit to 5 years | 
| mean of brain movements | Measurement by ultrasound between patients with Minor Neurocognitive Disorders (mNCD) and Major Neurocognitive Disorders (MNCD). | one a year from inclusion visit to 5 years | 
| standard deviation of brain movements | Measurement by ultrasound between patients with Minor Neurocognitive Disorders (mNCD) and Major Neurocognitive Disorders (MNCD). | one a year from inclusion visit to 5 years | 
| powers in frequency analysis | Measurement by ultrasound between patients with Minor Neurocognitive Disorders (mNCD) and Major Neurocognitive Disorders (MNCD). | one a year from inclusion visit to 5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Brain pulse | Longitudinal comparison between converter patients (patients with mNCD progressing to MNCD) and non-converters patients | one a year from inclusion visit to 5 years | 
| Brain pulse | Cross-sectional and longitudinal analysis between the different types of pathologies underlying NCD (Alzheimer's disease, Vascular NCD, Frontotemporal Lobar Degeneration, Lewy body disease, etc.) according to the Diagnostic and Statistical Manual of mental disorders criteria for these pathologies | one a year from inclusion visit to 5 years | 
| Hippocampal volume | Measured in MRI. Comparison with brain pulse according to Schelten classification | one a year from inclusion visit to 5 years | 
| leucoaraiosis load | Measured in MRI. Comparison with brain pulse according to Fazekas classification | one a year from inclusion visit to 5 years | 
| Carbohydrate metabolism | Measured with PET-FDG in regions of interest involved in neurodegenerative diseases. Comparison with brain pulse | one a year from inclusion visit to 5 years | 
| Spinal fluid biomarkers | Determination of amyloid and tau proteins in spinal fluid. Comparison with brain pulse | one a year from inclusion visit to 5 years | 
| cohort study on brain pulsatility with neuropsychological measures | Comparison between brain pulsatility parameters and standard neuropsychological test scores used for cognitive assessment of patients with NCD. neuropsychological test scores are optional at each visit | one a year from inclusion visit to 5 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Brain pulse, ultrasound