Antibiotic Therapy in Infections of the Diabetic Foot Syndrome

Study Overview
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Brief Summary
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This retrospective study examines the surgical and antibiotic treatment of diabetic foot syndrome infections treated at the University Hospital Basel since 2019. It analyses the implementation of the hospital in-house guidelines published in 2019 with regard to antibiotic therapy in diabetic foot infections, taking into account clinical, microbiological and histopathological criteria. The defined endpoints are (i) fully compliant with internal policies, (ii) partially compliant with internal policies, and (iii) not compliant with internal policies. The recording of these proportions is descriptive.

Detailed Description
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This retrospective study examines the surgical and antibiotic treatment of diabetic foot syndrome infections treated at the University Hospital Basel since 2019. (In 2019 the departments of infectiology and orthopedics at the University Hospital Basel published recommendations with regard to the duration of antibiotic therapy in infections of the diabetic foot syndrome. This depends on whether a surgical intervention was performed and takes into account both the microbiological and the histopathological samples). Data that are routinely collected in everyday clinical practice and stored in the hospitals' medical records will be evaluated. The aim of this research project is to check the implementation of these recommendations. Inadequate use of antibiotics should thus be recognized. The study has the aspect of quality control.

Official Title
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Antibiotische Therapie In Infektionen Des Diabetischen Fusssyndroms

Conditions
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Diabetic Foot Infection

Intervention / Treatment
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* Other: Data collection in patients with diabetic foot syndrome and infections in the area of the foot


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: soft tissue infection or bone infection (incl. osteomyelitis) in diabetic foot syndrome inpatient stay at the University Hospital Basel between January 1st, 2019 and December 31st, 2021 surgical intervention (amputation and/or debridement) signed general consent Exclusion Criteria: datasets without a diagnosis of the diabetic foot no surgical intervention performed (amputation and/or debridement) surgical interventions performed by disciplines other than orthopaedics/traumatology (e.g. vascular surgery) infections in osteosynthesis material (implant or fracture-associated infections)

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Data collection in patients with diabetic foot syndrome and infections in the area of the foot|Data collection: on (surgical and antibiotic) treatment and implementation of the recommendations published 2019 with regard to the duration of antibiotic therapy.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Compliance with the hospital in-house guidelines for diabetic foot infections with regard to antibiotic treatment | Implementation of the guidelines published in 2019 with regard to antibiotic therapy in diabetic foot infections, taking into account clinical, microbiological and histopathological criteria. The defined endpoints are (i) fully compliant with internal policies, (ii) partially compliant with internal policies, and (iii) not compliant with internal policies. | one time assessment at baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Duration of antibiotic therapy (days) | Duration of antibiotic therapy | one time assessment at baseline | 
| Relapse of diabetic foot infections (number) | Relapse of diabetic foot infections (number) | one time assessment at baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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diabetic foot syndrome, antibiotic therapy, soft tissue infection, osteomyelitis, bone infection