Endoscopic Resection of Gastrointestinal Neoplasms

Study Overview
=================
Brief Summary
-----------------
The study aims to retrospectively investigate the endoscopic resection procedures of cancerous and precancerous lesions of the upper and lower digestive tract in order to evaluate the efficacy and safety outcomes and to compare different resection techniques. In particular, the resection techniques investigated will be mucosectomy, en bloc and piecemeal, endoscopic submucosal dissection (ESD) and its variants, full-thickness resection. The anatomical districts involved will be the esophagus, stomach, duodenum, colon and rectum.

Official Title
-----------------
Retrospective Study of Efficacy and Safety of the Endoscopic Removal of Cancerous and Precancerous Lesions of the Upper and Lower Digestive Tract

Conditions
-----------------
Endoscopic Mucosal Resection, Endoscopic Submucosal Dissection, Gastric Neoplasm, Colonic Neoplasms, Esophageal Neoplasms, Duodenal Neoplasms

Intervention / Treatment
-----------------
* Procedure: Endoscopic resection


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 18 years or older all patients who have undergone endoscopic resection of an upper or lower digestive tract tumor Exclusion Criteria: age under 18 inability to provide informed consent

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 100 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Endoscopic resection|The endoscopic resection is the procedure that allows to remove cancerous or precancerous conditions of digestive tract. Endoscopic resection can be preformed by several techniques: Endoscopic mucosal resection (EMR): it allows to remove mucosal lesions Endoscopic submucosal dissection: it allows to remove mucosal lesions that involved submucosal layer and large lesions Full-thickness resection: it allows to remove infiltrating lesions by the resection of a little piece of the entire gastrointestinal wall|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| en bloc resection rate | the en bloc resection is the ability to remove the neoplasia in a single piece | one month | 
| complete resection rate | the complete resection is the ability to remove the neoplasia with clear margins (R0) | one month | 
| recurrence rate | recurrence is the recurrence of the neoplasm at the resection site during follow-up | one year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| adverse events rate | complication rate, early or late, related to the procedure used for endoscopic resection | one month | 
| costs | evaluation of the costs incurred to perform the endoscopic resection | one month | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Colorectal ESD, Colorectal EMR, Endoscopic mucosal resection (EMR), Endoscopic submucosal dissection (ESD), Endoscopic full thickness resection (EFTR)