Structural and Functional Brain Reorganization in Neuropathic Pain: Basal State of Local Cerebral Blood Flow and Functional Connectivity

Study Overview
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Brief Summary
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Neuropathic pain is a medical condition involving allodynia (painful perceptions in response to stimuli that normally are not) and spontaneous pain (occurring at rest, without stimulation). This pain is secondary to nervous system injury affecting the sensory system. The lesion is either at the nerve endings of the spinal cord or brain. It induces a loss of sensitivity and likely reorganization of brain activity that are causing pain and which are the subject of this study. Previous studies in functional neuroimaging has focused on brain areas activated during allodynic stimuli compared to non-painful stimuli. The abnormalities have been reported, but it was not possible to conclude formally. The authors failed to assess the part of the effect of the loss of sensory afferents (deafferentation) and the basal brain function. Indeed, the operation without any sensory stimulation is not known yet is the initial level of activity which is the benchmark for studying brain function during stimulation. The objective of this study is to understand what are the cortical systems of allodynic dysfunctional in patients compared with controls at baseline.

Official Title
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Structural and Functional Brain Reorganization in Neuropathic Pain: Basal State of Local Cerebral Blood Flow and Functional Connectivity

Conditions
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Neuropathic Pain

Intervention / Treatment
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* Radiation: MRI scan


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria for patients : major with nervous pain : chronic or peripheric treatment not stable opioid since one week signed consent Inclusion Criteria for witnesses : major without chronic pain signed consent Exclusion Criteria for 2 groups : severe psychiatric history presence of an active nervous lesion subject with morphine treatment contraindication to MRI scan

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: peripheric nervous lesion<br>MRI scan | Radiation: MRI scan<br> <br> |
| Experimental: medullar or encephalic lesion<br>MRI scan | Radiation: MRI scan<br> <br> |
| Other: control group<br>MRI scan | Radiation: MRI scan<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| cerebral blood flow | quantified with MRI scan | at baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| rate of grey matter | difference between groups | at baseline | 
| structure of the networks | Determine if structure of the networks is different between patients and controls. Measured with MRI scan. | at baseline | 
| connection of the networks | Determine if connection of the networks is different between patients and controls. Measured with MRI scan. | at baseline | 
| cortical loss | Assess the cortical loss of the patient group compared to controls. Measured with MRI scan. | at baseline |