Taichi for Overweight/Obese Adolescent and Young Women With Polycystic Ovary Syndrome (PCOS)

Study Overview
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Brief Summary
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The present study is a randomized pilot study, overweight/obese adolescent and young PCOS subjects will be assigned into two groups: Taichi arm and control arm. Hormonal profile and metabolic profile will be determined.

Official Title
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Taichi for Treating Overweight/Obese Adolescent and Young Women With Polycystic Ovary Syndrome (PCOS)

Conditions
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Polycystic Ovary Syndrome

Intervention / Treatment
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* Behavioral: Taichi
* Behavioral: Self-monitored exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Women aged between 19 and 35 years; Diagnosis of PCOS according to the modified Rotterdam criteria; 2 years after menarche; Body mass index (BMI) equal to or greater than 23 kg/m*m. Exclusion Criteria: Administration of other medications known to affect reproductive function or metabolism within the past three months, including oral contraceptives, Gonadotropin-releasing hormone (GnRH) agonists and antagonists, anti androgens, gonadotropins, anti-obesity drugs, Chinese herbal medicines, anti diabetic drugs such as metformin and thiazolidinediones, somatostatin, diazoxide, and calcium channel blockers. Patients with other endocrine disorder including 21-hydroxylase deficiency, hyperprolactinemia, uncorrected thyroid disease, suspected Cushing's syndrome. Patients with known severe organ dysfunction or mental illness.

Ages Eligible for Study
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Minimum Age: 19 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Taichi<br>The 24 forms of simplified TCC recommended as the popular health sport by the General Administration of Sport of China were applied. | Behavioral: Taichi<br>* The program of Taichi training consisted of 60 minutes exercise sessions, 3 days per week for 12 weeks, based on their original level of physical activity. Each session comprised 40 minutes of Taichi training plus a 10-minute warm-up and cool-down. The Taichi training was instructed by the same experienced Taichi instructors who were qualified in the teaching of Taichi. The 24 forms of simplified Taichi recommended as the popular health sport by the General Administration of Sport of China were applied.<br>|
| Active Comparator: Self-monitored exercise<br>Exercise was self-monitored and consisted of brisk walking, cycling, jogging, or any other aerobic exercise. | Behavioral: Self-monitored exercise<br>* Exercise was self-monitored and consisted of brisk walking, cycling, jogging, or any other aerobic exercise for 60 mins. 3 days per week for 12 weeks.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Body mass index (BMI) |  | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fasting plasma glucose (Glu) |  | 3 months | 
| Fasting insulin (Ins) |  | 3 months | 
| HOMA-IR | HOMA-IR = fasting insulin concentrations (mIU/L) ×fasting plasma glucose concentrations (mmol/L)/22.5 | 3 months | 
| Testosterone (T) |  | 3 months | 
| Luteinizing hormone (LH) |  | 3 months | 
| Follicle stimulating hormone (FSH) |  | 3 months | 
| Waist/hip ratio |  | 3 months | 
| Ferriman-Gallwey score |  | 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Polycystic ovary sybdrome, Taichi