Cooperative Adenomyosis Network

Study Overview
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Brief Summary
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To set up a Cooperative Network by enrolling 5000 patients with Adenomyosis(AM) from multiple centers.Based on the Network platform and Database,the investigators try to explore the diagnostic strategies for AM and carry out epidemiological survey on the semeiology of AM.In addiction，the investigators expect to conduct research on the effect and the follow-up fertility outcomes of different medical or surgical treatment, the etiology of AM and endometriosis,the perspective investigation of the malignant transformation of AM ;the high-risk factors of AM,and finally propel the formation of Expert Consensus and Clinical Guidelines about AM which suitable to chinese conditions.

Detailed Description
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5000 women diagnosed of Adenomyosis(AM) with pathology, transvaginal ultrasonography or magnetic resonance image（MRI）will be enrolled from nationwide multicenters. The investigators would build up Network platform, and database with the registered data within 6 months. 30-month follow-up with an interval of at least once every 6 months will be done for every patient ，and update the database timely. Based on the Network platform and Database,we try to explore the diagnostic strategies for AM and carry out epidemiological survey on the semeiology of AM.In addiction，the investigators expect to conduct research on the effect and the follow-up fertility outcomes of different medical or surgical treatment,the etiology of AM and endometriosis,the perspective investigation of the malignant transformation of AM ;the high-risk factors of AM,and finally propel the formation of Expert Consensus and Clinical Guidelines about AM which suitable to chinese conditions.

Official Title
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A Study of Cooperative Network of Diagnosis and Treatment of Uterine Adenomyosis.

Conditions
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Dysmenorrhea, Metrorrhagia, Infertility, Female, Pathology, Ultrasonography, Radiography

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Women diagnosed of adenomyosis by pathology, transvaginal ultrasound or MRI. Exclusion Criteria: Refusal to join the study
Sexes Eligible for Study
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Female

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Different Treatment Groups<br>Women would receive different pharmacotherapy from the standard approach，such as levonorgestrel-releasing intrauterine system(LNG-IUS)，Gonadotrophin releasing hormone agonist(GnRH-a),surgery,etc. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Therapeutic effect and Diagnostics | Symptom Assessment | 2day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pathology | Diagnostic assessment | 1day | 
| selection of therapeutic scheme | pharmacotherapy or surgery | 1day | 
| vision algetic standard（VAS） | Semeiology and evaluative criteria | 2day | 
| B type ultrasound | Diagnostic assessment | 1day | 
| Magnetic Resonance Imaging | Diagnostic assessment | 1day | 
| pictorial blood loss assessment chart（PBAC） | Semeiology and evaluative criteria | 2day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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adenomyosis, diagnosis, treatment, epidemiology, Complications