Cyanoacrylate and Laser and Dentin Sensitivity

Study Overview
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Brief Summary
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This study aimed to evaluate the effectiveness of two treatments for dental hypersensitivity: cyanoacrylate (Super Bonder®) compared with use of low intensity laser treatment (LILT). As the cyanoacrylate is a lower cost treatment, the hypothesis in investigation is if this product is equally effective as the laser treatment.

Detailed Description
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The present study included 62 patients (15 male and 47 females, aged 12 to 60 years). The initial cervical dentin hypersensitivity was checked throughout a thermal test (air blast). The 434 teeth included were that with a score ≥5 in a numerical scale rating of pain. Teeth were randomly assigned according quadrants (split mouth design) - 216 were allocated to LILT group and 218 for the Super Bonder® group. Thermal tests with a tetrafluoroethane spray (Endo-Ice®) and air blast were performed and considered as baseline. Pain parameters were recorded using a numerical scale rating with 24 hours, 30, 90 and 180 days after the interventions. Quality of life of the patients was also assessed with the use of OHIP-14 at baseline and after 180 days.

Official Title
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Effectiveness of Cyanoacrylate and Laser in the Treatment of Cervical Dentin Sensitivity

Conditions
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Dentin Hypersensitivity, Dentin Sensitivity

Intervention / Treatment
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* Other: Cyanoacrylate
* Radiation: Laser


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients should be in good general and dental health; present complaints of dental sensitivity to cold, sweet, acidic foods and brushing; present complaints of pain in teeth located in different quadrants; manifest pain or discomfort upon application of the triple syringe air jet; not be in current use of desensitizing agents. Exclusion Criteria: presence of extensive restorations and carious lesions in the sensitive teeth; undergoing orthodontic treatment; frequent use of analgesics, antidepressants and anti-inflammatory drugs; presence of gingival inflammation; non-consent of patient.

Ages Eligible for Study
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Minimum Age: 12 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Cyanoacrylate<br>3 applications of cyanoacrylate (48 hours interval)at the cervical region of the sensitive tooth | Other: Cyanoacrylate<br>* 3 applications of cyanoacrylate (48 hours interval) at the cervical region of the sensitive tooth<br>* Other names: Superbonder;|
| Active Comparator: Laser<br>3 Low intensity laser application (48 hour interval). The application of 1Joule/cm^2 was performed for eight seconds at three points along the dental neck, using the infrared wavelength (795nm) | Radiation: Laser<br>* This process was conducted three times with an interval of 48 hours between applications, according to laser's manufacturer advice Clean Line Easy Laser - LILT®, Clean Line Easy Laser Doctor Dental Products Industry LTDA, BRA). For dentin hypersensitivity, the application of 1Joule/cm^2 is recommended for eight seconds at three points along the dental neck, using the infrared wavelength (795nm).<br>* Other names: LILT;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of the Pain Sensitivity | Change in pain experienced by the participants was calculated as the difference between baseline level of pain sensitivity and after 180 days. Pain was recorded using a numerical pain assessment scale with range between 0 (no pain) to 10 (worst possible pain). The higher the numbering the worse the result. | Baseline and 180 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quality of Life Improvement | Difference between the level of quality of life - Oral Health Impact Profile OHIP at baseline and 180 days. OHIP-14 total scale ranges from 0 to 56 points with higher scores indicating a poorer oral health-related quality of life. The response format uses a Likert-type frequency scale such as follows: very often = 4, fairly often = 3, occasionally = 2, hardly ever = 1, never = 0. Total score is obtained by summing the response codes of the 14 items constituting the measure. | Baseline and 180 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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laser, dentin hypersensitivity, cyanoacrylate