The Oral Microbiota is Associated With Autoimmune Thyroiditis

Study Overview
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Brief Summary
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Autoimmune thyroiditis (AITD) mainly includes Hashimoto's thyroiditis (HT) and Grave's disease (GD). Studies have shown that autoimmune thyroiditis is closely related to microbial disorders such as autoimmune thyroiditis However, there is no report on the relationship between oral microecology and autoimmune thyroiditis. Therefore, our group will study the correlation between oral microbiota and AITD.

Detailed Description
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Autoimmune thyroiditis (AITD) mainly includes Hashimoto's thyroiditis (HT) and Grave's disease (GD). Studies have shown that autoimmune thyroiditis is closely related to microbiological disorders. Intestinal microelements Both ecology and oral microecology belong to the category of microorganisms. It has been reported in the literature that intestinal microecology occurs disorder of autoimmune thyroiditis. However, there is no report on the correlation between oral microecology and autoimmune thyroiditis. When oral microbe flora When the immune system is disrupted, the immune balance is broken, the immune system is over-active, and the autoimmune disease (AID) is lost to the autoantigens and non-pathogenic commensal microbial flora antigens, including rheumatoid arthritis, Sjogren's syndrome, systemic lupus erythematosus, inflammatory bowel disease, and allergic diseases. However, the association between oral microbial flora and AITD remains unclear. . Therefore, the research group will carry out the correlation between oral microbial flora and AITD.

Official Title
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The Oral Microbiota in Autoimmune Thyroiditis is Distinctive And Predictive

Conditions
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Microbiota

Intervention / Treatment
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* Drug: Methimazole Pill
* Drug: Propylthiouracil Pill


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Aged 18 to 65 years GD was clinical diagnosed and thyroid function returned to normal HT was clinical diagnosed and thyroid function is normal. Exclusion Criteria: Pregnancy Lactation Cigarette smoking Alcohol addiction Hypertension Diabetes mellitus Lipid dysregulation BMI > 27 Recent (< 3 months prior) use of antibiotics, probiotics, prebiotics, symbiotics, hormonal medication, laxatives, proton pump inhibitors, insulin sensitizers or Chinese herbal medicine History of disease with an autoimmune component, such as MS, rheumatoid arthritis, IBS, or IBD History of malignancy or any gastrointestinal tract surgery

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Control group<br>30 healthy volunteers were included in the healthy control group | |
| Drug treatment group<br>30 GD patients who received treatment with Methimazole Pill or propylthiouracil pill | Drug: Methimazole Pill<br>* Patients who developed GD received methimazole treatment<br>Drug: Propylthiouracil Pill<br>* Patients who developed GD received propylthiouracil treatment<br>|
| Incipient group<br>30 untreated GD patients | |
| Hashimoto's thyroiditis group<br>30 HT patients | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Transcriptional changes in oral microbiota | The microbiota measured by 16S rRNA gene | Baseline, 3 months, 6 months, 9 months, 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Serum thyroid function changed | Serum thyroid function measured by Immunohistochemistry | Baseline, 3 months, 6 months, 9 months, 12 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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oral microbiota, 16S rRNA gene, Graves' disease, Methimazole, Propylthiouracil, Hashimoto's thyroiditis