Effect of Life Kinetik Training on Lower Limb Coordination in Ataxic Patients

Study Overview
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Brief Summary
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Coordination is essential for the performance of most daily motor activities. Coordination problems are common in MS patients. One of the most commonly reported symptoms is dysmetria (limb ataxia). Ataxia is thought to occur in about 80% of MS patients. It leads to limitations in daily life activities. Aim of Study: to investigate the effect of life kinetik training on lower limb coordination in MS patients with ataxia.

Detailed Description
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Methods: Thirty remitting relapsing Multiple Sclerosis (RRMS) patients from both sexes with ataxic symptoms, will be recruited from multiple sclerosis specialized clinic in the Neurology department, Faculty of Medicine, Cairo University with EDSS score will be ranged from 2 to 4 and SARA score will be ranged from 1 to 10. Lower Extremity Motor Coordination Test (LEMOCOT) will be used to assess lower limb motor coordination. They will be randomly assigned into two equal groups; control group (GI) will receive selected physical therapy program and study group (GII) will receive same program of (GI) in addition to life kinetik training.

Official Title
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Effect of Life Kinetik Training on Lower Limb Coordination in Ataxic Patients

Conditions
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Ataxia, Multiple Sclerosis

Intervention / Treatment
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* Other: physical therapy
* Other: life kinetic exercises


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: MS from both sexes Patients' age will be ranged from 20 to 45 years Expanded disability scale (EDSS) score ranging from two to four Exclusion Criteria: Patients with Ataxia caused by other cause rather than MS Patients with other neurological disease or orthopedic deformities may affect movement Patients with cardiovascular and pulmonary diseases that make exercise unsafe Patients with cognitive impairment or psychiatric disorders

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: randomized controlled trail
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: study group<br>will receive physical therapy program of in addition to life kinetik training. | Other: physical therapy<br>* Frenkel's exercises for lower limb, Proprioceptive neuromuscular facilitation for upper limb in the form of rhythmic stabilization<br>Other: life kinetic exercises<br>* A multimodal training that combines coordinative, cognitive and visual tasks.<br>|
| Active Comparator: control<br>will receive physical therapy program | Other: physical therapy<br>* Frenkel's exercises for lower limb, Proprioceptive neuromuscular facilitation for upper limb in the form of rhythmic stabilization<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Lower Extremity Motor Coordination Test (LEMOCOT) | test to assess lower limb coordination | at baseline | 
| Lower Extremity Motor Coordination Test (LEMOCOT) | test to assess lower limb coordination | post intervention (after one month) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Four Square Step Test (FSST) | test to assess dynamic balance | at baseline | 
| Four Square Step Test (FSST) | test to assess dynamic balance | post intervention (after one month) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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ataxia, Multiple Sclerosis, coordination, life kinetic exercises