Thoracic Epidural Versus General Anesthesia for Laparoscopic Cholecystectomy

Study Overview
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Brief Summary
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Eighty two patients planned to undergo elective laparoscopic cholecystectomy were divided into two groups, T and G, randomly. In Group T all patients underwent laparoscopic cholecystectomy under thoracic epidural anesthesia with 12mlof 0.25% bupivacaine and 1% lignocaine plain whereas in group G all patients underwent surgery under general anesthesia. Intra-operative heart rate, mean arterial pressure (MAP) and post operative opioid consumption in first 24hrs were recorded as primary outcomes whereas presence or absence of respiratory complication and duration of hospital stay as secondary outcome.

Official Title
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Thoracic Epidural Versus General Anesthesia for Laparoscopic Cholecystectomy: A Randomized Controlled Trial

Conditions
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Epidural Anesthesia, General Anesthesia

Intervention / Treatment
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* Drug: Thoracic epidural effect on heart rate in Laparoscopic Cholecystectomy (bupivacaine and lignocaine)
* Drug: general anesthesia effect on heart rate in Laparoscopic Cholecystectomy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients having ASA statusI-III age more than 18 years, both genders planned to undergo laparoscopic cholecystectomy Exclusion Criteria: Patients who did not give consent, Allergic to local anesthetic Hemodynamically unstable, Pregnant, full stomach patients

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: one group to be studied for effects of epidural anesthesia and other group for effects of general anesthesia
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: group receiving thoracic epidural anesthesia<br> | Drug: Thoracic epidural effect on heart rate in Laparoscopic Cholecystectomy (bupivacaine and lignocaine)<br>* patients in epidural anesthesia were given epidural anesthesia and assessed for heart rate and mean arterial pressure<br>* Other names: Thoracic epidural effect on mean arterial pressure in Laparoscopic Cholecystectomy;|
| Active Comparator: group receiving thoracic general anesthesia<br> | Drug: general anesthesia effect on heart rate in Laparoscopic Cholecystectomy<br>* patients in general anesthesia were given epidural anesthesia and assessed for heart rate and mean arterial pressure<br>* Other names: general anesthesia effect on mean arterial pressure in Laparoscopic Cholecystectomy;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| effectiveness of thoracic epidural anesthesia with general anesthesia for Laparoscopic cholecystectomy in terms of change in heart rate during surgery in immediate 24 hours-heart rate. | the efficacy of thoracic epidural anesthesia was compared with general anesthesia for laproscopic cholecystectomy in the immediate post operative period in terms of intra operative heart rate. | changes in heart rate at 24 hours of surgery. | 
| effectiveness of thoracic epidural anesthesia with general anesthesia for Laparoscopic cholecystectomy in terms of change in mean arterial blood pressure during surgery in immediate 24 hours-mean arterial blood pressure. | efficacy of thoracic epidural anesthesia was compared with general anesthesia for laproscopic cholecystectomy in the immediate post operative period in terms of mean arterial blood pressure intra operatively and in immediate post operative period | changes in mean arterial pressure at 24 hours of surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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headache, blood pressure