Patients' Outcome With Severe or Fulminant Hepatic Insufficiency, Hospitalized in the Public Hospitals of Paris

Study Overview
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Brief Summary
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The main objective is to determine the medical fate (transplanted or not and living or deceased), of patients with Severe, fulminating acute liver failure in the public hospitals of paris.

Detailed Description
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Severe, fulminating acute liver failure is a rare but serious disease. The overall prognosis has improved in recent years thanks to advances in medical management and liver transplantation. However, the epidemiology of this disease in France, the survival with or without liver transplantation of these patients and the factors that can influence this survival are not well known. The main objective is to determine the medical fate (transplanted or not and living or deceased), of patients with Severe, fulminating acute liver failure in the public hospitals of paris (APHP). The data will come from the APHP Health Data Warehouse

Official Title
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Patients' Outcome With Severe or Fulminant Hepatic Insufficiency, Hospitalized in the Hospitals of the Assistance Publique - Hôpitaux de Paris (APHP)

Conditions
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Fulminating Hepatic Failure

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age > 15 Severe liver failure or toxicants that may cause a liver failure Or (PR<50% or INR >1.5) And ALT >250 Exclusion Criteria: Patients with underlying chronic liver disease Patients with the conditions given by this following ICD (International Classification of Diseases) : B18 - E831 - K70 - K715 - K717 - K730- K731 - K732 - 738 - K74 - K753 - K758 - K760 - K761

Ages Eligible for Study
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Minimum Age: 15 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| all patients diagnosed with a severe hepatic failure<br>Retrospective cohort using only data already entered in the Health data warehouse of the APHP (Public Paris Hospital) | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The main objective is to determine the medical fate (transplanted or not and living or deceased), of patients with Severe and fulminating acute hepatic failure within AP-HP hospitals | Patient status 1 month after diagnosis of this episode (alive or dead with or without transplantation) | 1 month from the diagnosis of this episode | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Epidemiology of Severe and fulminating acute hepatic failure | Sex Ratio M / F and cause of liver failure | Baseline | 
| Cause of death | Cause of death | From date of inclusion until the date of death from any cause, assessed up to 9 years | 
| Analysis of Clinical Pathway | Identification of the different services visited | up to 1month after the diagnosis of this episode | 
| Reasons for new hospitalizations with an admission date within 6 months after the diagnosis this episode | Identification by the usual code of the new hospitalization, consecutive to the episode | within 6 months after the diagnosis this episode |