Frontal Amplitude-integrated Electroencephalogram in Early Prognostication After Cardiac Arrest

Study Overview
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Brief Summary
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The investigators examine the prognostic value of continuous electroencephalography on frontal area of brain according to time by performing amplitude-integrated electroencephalography (aEEG) on cardiac arrest patients receiving therapeutic hypothermia.

Official Title
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Prospective Multi-center Study to Verify Neurological Prognostic Value of Amplitude-integrated Electroencephalogram in Cardiac Arrest Patients Treated With Therapeutic Hypothermia

Conditions
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Heart Arrest

Intervention / Treatment
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* Device: Amplitude integrated electroencephalography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age: 19 years and older underwent TH Exclusion Criteria: Died within 72 h after cardiac arrest Spontaneous or traumatic brain injury Known history of neurological diseases (such as epilepsy)

Ages Eligible for Study
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Minimum Age: 19 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Comatose cardiac arrest survivors<br> | Device: Amplitude integrated electroencephalography<br>* Frontal Amplitude-integrated Electroencephalogram in Early Prognostication After Cardiac Arrest<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of time to normal trace to good neurological outcome evaluated by cerebral performance category (CPC) score 1 to 2 | Time to normal trace is defined as time to regained normal trace on aEEG after return of spontaneous circulation. The normal trace is defined as continuous cortical activity on the raw EEG scan; in addition, the upper margin of the aEEG scan, referred to as the aEEG maximum, was >10 uV, and the lower margin of the aEEG scan, referred to as the aEEG minimum, was >5 uV. | at day 180 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of time to normal trace to poor neurological outcome evaluated by CPC score 3 to 5 | Time to normal trace is defined as time to regained normal trace on aEEG after return of spontaneous circulation. The normal trace is defined as continuous cortical activity on the raw EEG scan; in addition, the upper margin of the aEEG scan, referred to as the aEEG maximum, was >10 uV, and the lower margin of the aEEG scan, referred to as the aEEG minimum, was >5 uV. | at day 180 | 
| Comparison of unfavorable aEEG patterns to poor neurological outcome evaluated by CPC score 3 to 5 | Unfavorable aEEG patterns include flat trace (FT), burst-suppression (BS) and status epilepticus (SE). FT is defined as isoelectric activity. BS is defined as the virtual absence of activity (<2uV) between bursts of high voltage (>25 uV). SE was defined as repetitive epileptiform discharges with amplitudes >50 uV and a median frequency 1 Hz for >30 min. | at day 180 | 
| Comparison of diffusion weighted image (DWI) to poor neurological outcome evaluated by CPC score 3 to 5 |  | at day 180 | 
| Comparison of the levels of serum neuron specific enolase (NSE) to poor neurological outcome evaluated by CPC score 3 to 5 |  | at day 180 | 
| Comparison of convulsive movement and electrical status epilepticus (SE) to poor neurological outcome evaluated by CPC score 3 to 5 |  | at day 180 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Heart arrest, Hypothermia, EEG, Prognosis