Neurocognitive Dysfunction After Anesthesia in Patients With Recent Concussion

Study Overview
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Brief Summary
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Researchers are trying to determine if the impact of a concussion on the brain is affected by anesthesia and surgery.

Detailed Description
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All subjects will complete pre and post procedure assessments prior to undergoing a planned surgery/anesthetic standard of care.

Official Title
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Neurocognitive Dysfunction After Anesthesia in Patients With Recent Concussion

Conditions
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Concussion, Brain

Intervention / Treatment
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* Other: Neurocognitive Testing


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Male or Female >16 years of age with a recent concussion (<10 weeks) from planned procedure under anesthesia. Exclusion Criteria: Neurologic history including history of severe cognitive disease, disorder, or delay, attention disorder, moderate to severe TBI history, neurovascular order or trauma.

Ages Eligible for Study
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Minimum Age: 16 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Concussion Group<br>Subjects diagnosed with concussion defined as a clinician-diagnosed disease by the International Classification of Diseases (ICD)-10 due to a head injury with a Glasgow Coma Score ≥13 undergoing a planned surgery/anesthetic standard of care will undergo neurocognitive testing pre and post surgery/anesthetic. | Other: Neurocognitive Testing<br>* A comprehensive assessment of neuropsychometric measures to evaluate cognitive functioning.<br>|
| Experimental: Matched Subjects Group<br>Matched subjects without concussion undergoing a planned surgery/anesthetic standard of care, matching for procedural type, sex, age ± 2 years, and adherence to the exclusion criteria will undergo neurocognitive testing pre and post surgery/anesthetic. | Other: Neurocognitive Testing<br>* A comprehensive assessment of neuropsychometric measures to evaluate cognitive functioning.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Wide Range Achievement Test Fourth Edition, WRAT-4 | Change in WRAT-4 | Pre-anesthetic to one week Post-anesthetic | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Numeric Pain Scale 0-10 | Difference in numeric pain scale between the concussion and non-concussion group. Patients verbally select a value that is in line with the intensity of pain they have experienced in the last 24 hours. Pain Scale is recorded 0 = no pain, 10 = the most pain imaginable. | Post-operatively to hospital discharge, up to 10 days. | 
| Oral morphine equivalent of consumed opioids | Difference of post-operative opioid use between the concussion and non-concussion group | Post-operatively to hospital discharge, up to 10 days. | 
| Length of hospital stay | Difference between the concussion and non-concussion group | Post-operatively to hospital discharge, up to 30 days. | 
| Cognitive Deficits identified by NeuroPsychometric Cognitive Testing | Difference between the concussion and non-concussion group. | Pre-anesthetic to one week Post-anesthetic | 
| Sport Concussion Assessment Tool - 5th edition, SCAT-5 | The SCAT5 is a standardized tool for evaluating concussions designed for use by physicians and licensed medical professionals. Difference in SCAT5 scores between the concussion and non-concussion group. SCAT5 scores the number of symptoms (0-22) present and the severity of symptoms (0-132). | Pre-anesthetic to one week Post-anesthetic |