linjc16/ctgov huggingface dataset:
The Increase Study. Effect of Incremental Versus Fixed Pump on Peak Oxygen Consumption in Heart Failure Patients Supported With a Continuous Flow Left Venticular Assist Device

Study Overview
=================
Brief Summary
-----------------
The purpose of the study is to examine the relationship between working capacity (peak oxygen consumption) and pump speed of continuous flow left ventricular assist devices (CF-LVADs)in heart failure patients. The hypothesis is that it is possible to increase peak oxygen consumption by incrementally increasing CF-LVAD pumpspeed during exercise. The study population will consist of severe heart failure patients with CF-LVADs treated at The Heart Centre of Copenhagen University Hospital Rigshospitalet.

Official Title
-----------------
The Increase Study. Effect of Incremental Versus Fixed Pump on Peak Oxygen Consumption in Heart Failure Patients Supported With a Continuous Flow Left Venticular Assist Device.

Conditions
-----------------
Heart Failure.

Intervention / Treatment
-----------------
* Device: Incremental pump speed of CF-LVAD.


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: HeartMate II patients who underwent surgery and follow-up at The Heart Centre of Rigshospitalet. Heart failure in stable phase without the need for intravenous inotropic therapy. Ischemic and non-ischemic cardiomyopathy. Exclusion Criteria: Severe aortic insufficiency.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Randomized
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: CF-LVAD pumpspeed.<br>Optimal pumpspeed setting of CF-LVAD during exercise on ergometric bicycle. | Device: Incremental pump speed of CF-LVAD.<br>* Peak oxygen consumption with fixed versus incremental pump speed.<br>* Other names: HeartMate II.;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Peak oxygen consumption. | ml oxygen/minute/kg | Day 1 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Working capacity. | Watt | Day 1 |
Study on 'The Use of Non-contrast Helical Computerized Tomogram in Predicting Treatment Outcomes of Upper Ureteric Stone by Extracorporeal Shock Wave Lithotripsy Using the Sonolith 4000+ Lithotripter'

Study Overview
=================
Brief Summary
-----------------
The purpose of this research is to assess the role of non-contrast helical computerized tomogram in predicting the treatment outcome of upper ureteric stone by extracorporeal shock wave lithotripsy (ESWL).

Official Title
-----------------
The Use of Non-contrast Helical Computerized Tomogram in Predicting Treatment Outcome of Upper Ureteric Stone by Extracorporeal Shock Wave Lithotripsy Using the Sonolith 4000+ Lithotripter

Conditions
-----------------
Ureteral Calculi

Intervention / Treatment
-----------------
* Procedure: Non-contrast helical computerized tomogram (NCHCT)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adult patient (> 18 years old) With solitary upper ureteric stone (defined as ureter above the sacroiliac joint as seen on plain radiography) diagnosed by NCHCT *(* can have stones at the other site but the indexed stone is a solitary stone) Size 5 to 15 mm in the maximal diameter as measured from plain radiography. Planned for primary in-situ ESWL Exclusion Criteria: Patient contraindicated for ESWL - active urosepsis, coagulopathy, pregnant lady etc Presence of percutaneous nephrostomy or ureteric stent Suspected distal obstruction

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Non-contrast helical computerized tomogram (NCHCT)|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
upper ureteric stone
Familial Analysis of Keratoconus Risk

Study Overview
=================
Brief Summary
-----------------
The principal objective of this study is to evaluate the frequency of KC inside family of patients with confirmed KC. It's a familial, epidemiological, prospective, single-center study.

Detailed Description
-----------------
Keratoconus is a common bilateral progressive corneal ectatic disease causing visual impairment by inducing irregular astigmatism and corneal opacities. This disorder typically begins during teenage years, progresses until the age of 30 to 40 years and, in severe forms, may need a corneal transplantation. Currently, keratoconus has not known etiopathogenesis, and it is difficult to detect subclinical forms. Several risk factors seem to be implied, environmental and genetic : the risk of keratoconus in case of familial history of keratoconus isn't well known at that time, but seems to be important to consider to promote screening and follow up of patient with a familial history of keratoconus (KC).

Official Title
-----------------
Familial Analysis of Keratoconus Risk

Conditions
-----------------
Keratoconus

Intervention / Treatment
-----------------
* Other: genetic


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Case : patient carrier of keratoconus more than 7 years patient who didn't expressed opposition as for computerization and use of data concerning him Family of case to have a first degree family member (father, mother, brother, sister, child) carrier of keratoconus more than 7 years patient who didn't expressed opposition as for computerization and use of data concerning him Exclusion Criteria: ocular pathology or antecedent of modification of cornea (surgery, traumatism, ocular hypertension, keratitis) which could interfere with topographical analysis wearing of rigid contact lens for 15 days before exams, or flexible lens for 5 days before exams

Ages Eligible for Study
-----------------
Minimum Age: 7 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: genetic|Galilee exam - Corn analysis with Optiwave Refractive Analysis|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| proportion of diagnosed keratoconus |  | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Assesment of familial history on KC severity |  | 1 day | 
| Evaluation of KC severity |  | 1 day |
Mayo Clinic Cardiac Implantable Electronic Device MRI Registry

Study Overview
=================
Brief Summary
-----------------
Registry intends to prospectively collect data regarding the safety of magnetic resonance imaging (MRI) studies in patients with cardiac pacemakers on implantable cardioverter defibrillators.

Official Title
-----------------
Mayo Clinic Cardiac Implantable Electronic Device (CIED) Magnetic Resonance Imaging (MRI) Registry; Determining the Risks of of MRI in the Presence of Cardiac Implantable Electronic Devices

Conditions
-----------------
Magnetic Resonance Imaging

Intervention / Treatment
-----------------
* Radiation: MRI Scan


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Strong clinical indication for MRI; in the clinical setting where MRI is the diagnostic modality of choice for a specific disease state without acceptable alternative imaging technology Male or Female 18 years of age or older Able to provide informed consent Presence of CIED Exclusion Criteria: Presence of metallic objects that represent a contraindication to MR imaging, including: MRI-unsafe intra-orbital or intra-ocular retained metal fragments, and MRI-unsafe intracranial vascular clips and coils, other MRI-unsafe devices Morbid obesity (abdominal diameter greater than 60 centimeters) which results in contact wiht the magnet bore. Pregnant at time of scanning Pacemaker or Implanted Cardiac Device that is labeled as MRI-Conditional (approved by the Food and Drug Administration for exposure to MRI) Pacemaker dependent and either: 1) device implanted before 2005, or 2) advisory pulse generator that may lower outputs in the setting of radiofrequency currents

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| MRI Scan<br>Patients with a previously implanted Cardiac Implantable Electronic Device who are undergoing an MRI Scan for clinically indicated, diagnostic purposes. | Radiation: MRI Scan<br>* MRI scan with Specific Absorption Rate (SAR) limit of 1.5 watts per kilogram of body weight<br>* Other names: Magnetic Resonance Imaging;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cardiac Implantable Electronic Device Lead Impedance at Different Timepoints |  | Baseline, Visit 1, 3 months, 6 months | 
| Cardiac Implantable Electronic Device Lead Threshold at Different Timepoints |  | Baseline, Visit 1, 3 months, 6 months | 
| P/R Wave Amplitude at Different Timepoints |  | Baseline, Visit 1, 3 months, 6 months |
Analysis of Lateralization of Language in Epileptic Children by Near-infrared Spectroscopy (NIRS)

Study Overview
=================
Brief Summary
-----------------
Recent data published by various laboratories as well as our preliminary data tend to prove that near-infrared spectroscopy can be used to determine the lateralization of language as part of the preoperative assessment for drug-resistant epilepsy. The reference test used up until very recently was the Wada test, which consisted of injecting an anaesthetic (generally amobarbital sodium) into one of the internal carotid arteries (right or left) in order to determine the predominant cerebral hemisphere for language. This invasive test has been progressively replaced by fMRI, which is nevertheless difficult to perform in children under the age of 7 years. NIRS therefore appears to be a useful alternative, which, in contrast with fMRI, can be easily repeated and allows simple investigation of the various facets of language (e.g. expressive, receptive). In the GRAMFC unit, the investigators have acquired a unique know-how in the field of high-resolution NIRS, both in epilepsy and in the development of language structures.

Official Title
-----------------
Analysis of Lateralization of Language in Epileptic Children by Near-infrared Spectroscopy (NIRS)

Conditions
-----------------
Epilepsy

Intervention / Treatment
-----------------
* Device: NIRS
* Device: fMRI


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: children with drug-resistant partial epilepsy, in whom preoperative assessment is indicated. Exclusion Criteria: All children with severe congenital malformation Any refusal of a parent or child Any child with generalized epilepsy or diffuse interictal spikes Any child with a serious deterioration in the general condition and vital functions Any child with dermatitis of the face or scalp Children under 6 years

Ages Eligible for Study
-----------------
Minimum Age: 6 Years
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: patients<br>children with drug-resistant partial epilepsy, in whom preoperative assessment is indicated | Device: NIRS<br>* High-resolution EEG-fNIRS recording lasting a maximum of 30 minutes by using expressive and receptive language paradigms<br>Device: fMRI<br>* fMRI acquisition under the same stimulation conditions<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| lateralization index |  | 3 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
children, language, NIRS
Prehospital Transcranial Duplex in Patients With Acute Stroke

Study Overview
=================
Brief Summary
-----------------
The aim of the study is to investigate patients with acute stroke prehospital with transcranial duplex ultrasound to detect an infarct of the middle cerebral artery.

Detailed Description
-----------------
The investigation of the patients will be done by an anaesthesiologist who is part of the prehospital medical treatment in Germany. The main question is, wether a non neurologist can detect an infarction of the middle cerebral artery in a short time an lead the patient to the indicated clinic.

Official Title
-----------------
Prehospital Transcranial Duplex in Patients With Acute Stroke

Conditions
-----------------
Stroke

Intervention / Treatment
-----------------
* Other: No intervention in this study


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: clinical signs of acute stroke possibility of TCD Exclusion Criteria: acute interventions for vital signs required

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with clinical signs of stroke<br>Patients with clinical signs of stroke | Other: No intervention in this study<br>* No intervention in this study<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prehospital detection of an infarction of the middle cerebral artery in patients with acute stroke |  | 5 Minutes | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Stroke, prehospital ultrasound
Tomosynthesis Use in Detecting Subtle Occult Hip Fractures

Study Overview
=================
Brief Summary
-----------------
The purpose of this project is to determine if using tomosynthesis, in conjunction with x-ray, is better at detecting hip fractures than using x-ray alone. The goal of this study will be to include the use of tomosynthesis with x-ray as usual practice when a patient comes to the emergency room with symptoms of a hip fracture.

Official Title
-----------------
Tomosynthesis Use in Detecting Subtle Occult Hip Fractures

Conditions
-----------------
Hip Fracture

Intervention / Treatment
-----------------
* Device: Tomosynthesis


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Men and women aged > 18 years who/se: Present at the ER with a possible hip fracture and Have a negative x-ray for a hip fracture Physician has a high clinical suspicion of a hip fracture Provide provision of informed consent Exclusion Criteria: Hip prosthesis on the same side of the suspected hip fracture Other serious medical illness that is likely to interfere with study participation Significant psychiatric illness, senility, dementia, alcohol or substance abuse, which could impair the ability to provide informed consent and to adhere to the trial procedures Pregnant or suspected pregnancy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Tomosynthesis<br> | Device: Tomosynthesis<br> <br> * Other names: GE Discovery 650;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patients with hip fracture detected with tomosynthesis versus x-ray alone. |  | Participants will be followed up to 3 months post tomosynthesis exam. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| ER wait time |  | End of study | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Hip fracture, Tomosynthesis, X-ray, Emergency room
Investigation of the Clinical Performance of Silicone Hydrogel Contact Lenses During Continuous Wear

Study Overview
=================
Brief Summary
-----------------
The primary purpose of this study is to investigate the clinical performance of a new silicone hydrogel contact lens during continuous wear (up to 30 nights) over a period of 24 months.

Conditions
-----------------
Myopia

Intervention / Treatment
-----------------
* Device: Silicone hydrogel contact lens


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Has had an oculo-visual examination in the last 2 years. Is correctable to at least 6/7.5 distance visual acuity in each eye with spherical contact lenses. Is a current soft contact lens wearer. Has no clinically significant anterior eye findings. Has no other active ocular disease. Exclusion Criteria: Has any systemic disease that might interfere with contact lens wear Is using any systemic or topical medications that will affect ocular health. Has any pre-existing ocular irritation that would preclude contact lens fitting. Has any ocular pathology or severe insufficiency of lacrimal secretion (dry eyes) that would affect the wearing of contact lenses. Has undergone corneal refractive surgery. Is pregnant, lactating or planning a pregnancy.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: Silicone hydrogel contact lens|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Predictive Factors of Visual Recovery After Paraoptic Tumors Removal

Study Overview
=================
Brief Summary
-----------------
Paraoptic tumors - including mostly sellar meningiomas, pituitary gland adenomas and craniopharyngiomas - classically affect the visual function. Some preoperative factors, determined on retrospective studies, are known to constitute bad prognostic factors, such as duration of symptoms and retinal nerve fiber layer thinning on OCT. We propose to perform a single center prospective study in which detailed preoperative ophthalmological and radiological criteria will be collected before surgery. Intraoperative information will be noted as well. All these data will be statistically examined regarding the postoperative visual recovery at 3, 6 and 12 months

Official Title
-----------------
Paraoptic Tumors : Study of the Radiological, Ophthalmological and Intraoperative Predictive Factors of Visual Recovery After Neurosurgical Removal

Conditions
-----------------
Tuberculum Sellae Meningioma

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: tuberculum sellae meningioma surgical indication Exclusion Criteria: surgical contra indication MRI contra indication optical disease

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Tuberculum sellae meningiomas<br>Adult patient suffering from tuberculum sellae meningiomas with surgical treatment | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| variation of Visual field |  | between before surgery and 6 months postoperatively |
A Descriptive Study to Explore Certain Characteristics of Patients at Risk for Chronic Obstructive Pulmonary Disease (COPD) in a Primary Care Setting

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to explore if certain characteristics, easily detected within a regular primary care setting, may indicate that a patient at risk for COPD (45 ≤ age ≤ 80 years and a smoking history of ≥ 15 pack years) is prone to have a diagnosis of COPD according to Medical Products Agency guidelines.

Official Title
-----------------
A Descriptive Study to Explore Certain Characteristics of Patients at Risk for COPD in a Primary Care Setting

Conditions
-----------------
Chronic Obstructive Pulmonary Disease

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with a history of smoking one pack of cigarettes per day for 15 years or more Exclusion Criteria: Known Chronic Obstructive Pulmonary Disease Known severe cardiovascular disease

Ages Eligible for Study
-----------------
Minimum Age: 45 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No treatment<br>Patients with a smoking history of 15 pack years or more. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The patients will test their lung function with a COPD-6 screener for COPD and compare with regular spirometry. Medical records will be checked for health care contacts with respiratory diagnosis during the last 24 months prior to the study visit. |  | There will only be one visit in the study | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
COPD, COPD-6, Spirometry, VC, FEV, FEV1