Effects of Chiropractic Adjustments on Brain Function Using Quantitative Encephalography

Study Overview
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Brief Summary
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Despite the abundance of theories concerning the effects of chiropractic adjustments on brain function, this remains an understudies area for the profession. Quantitative Electroencephalography (qEEG)is a technique that allows for an in-depth analysis of brain function. A normative database will be used to compare before, during and after effects of chiropractic adjustments on brain function. This will include usage of Low Resolution Electromagnetic Tomography (LORETA). This study seeks to objectively document effects of chiropractic adjustments on brain function.

Official Title
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Effects of Chiropractic Adjustments on Brain Function Using Quantitative Encephalography

Conditions
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Brain Function

Intervention / Treatment
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* Other: Chiropractic adjustment
* Other: Sham adjustment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Must be able to receive chiropractic adjustments Exclusion Criteria: No benzodiazepine class drugs in study participants No use of medicines such as Sudafed (pseudoephedrine) or Nyquil (Doxylamine succinate) At least 30 days since last chiropractic adjustment

Ages Eligible for Study
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Minimum Age: 10 Years
Maximum Age: 99 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Health Services Research
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Sham Comparator: Placebo group<br>Ten people. Participants will receive what appears to be a chiropractic adjustment but which actually is not. This is the sham adjustment. Participants will also fill out Achenbach questionnaire. There will be a follow up in 7 days. | Other: Sham adjustment<br> <br> |
| Active Comparator: Chiropractic adjustment<br>Ten people. Group will be getting chiropractic adjustments. Participants will be filling out Achenbach questionnaire. There will be a follow up in 7 days. | Other: Chiropractic adjustment<br> <br> |
| No Intervention: Control group<br>Ten people. This group will simply have their EEG recorded at baseline and after 7 days. There will be an Achenbach questionnaire like the two other groups. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in quantitative EEG values as compared to a normative database | There will be a baseline measurement. There will be measurements during the adjustment. There will be measurements immediately after the adjustment. There will be measurements 7 days after the adjustment. Data will then be analyzed comparing values to a normative database. This database is adjusted for age. This will generate z-score values in addition to raw EEG values. Statistical analysis of P-values will then be run to test significance of changes. | Baseline, during adjustment, after adjustment, follow up in 7 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Behavioral assessment questionaire | Subject will be asked to complete the Achenbach System of Empirically Based Assessment. This assessment asks questions about subjects adaptive and maladaptive functioning. This information is comparing the subject to other people their age. | At baseline, one week after adjustment. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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quantitative encephalography, brain computer interface, chiropractic, sacro-occipital technique