Efficacy of the Extract of Carica Papaya as an Inhibitor of Streptococcus Mutans

Study Overview
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Brief Summary
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Papaya has effects on oral pathogenic microorganisms, it also has anticoagulant quality, amebicidal action, antimicrobial, bacteriostatic and antifungal activity on different bacteria, especially on Streptococcus mutans, this can be exploited in the dental area. The objective of the study was to determine the efficacy of Carica Papaya peel extract (suckling) as an inhibitor of Streptococcus Mutans in students of the dental faculty of the National University of Caaguazú in 2018.

Detailed Description
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Specific objectives To determine the inhibition of the extract of the peel of Carica Papaya (baby) at 3% on Streptococcus Mutans by age and sex grouping. To quantify the inhibition of the extract of the peel of Carica Papaya (baby) at 3% on the growth of Streptococcus Mutans before, at 10 minutes and 8 days of use in the experimental group. Quantify the inhibition of 0.12% Chlorhexidine Gluconate on the growth of Streptococcus Mutans before, after 10 minutes and 8 days of use in the control group. Compare the count of Colony Forming Units (CFU) between both groups.

Official Title
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Efficacy of the Extract of Carica Papaya as an Inhibitor of Streptococcus Mutans in Students of the Faculty of Dentistry in the Year 2018

Conditions
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Dental Plaque, Streptococcus, Other Specified Group

Intervention / Treatment
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* Other: CARICA PAPAYA MOUTHWASH
* Other: CHLORHEXIDINE MOUTHWASH


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Participants that signed the informed consent Exclusion Criteria: allergic to carica papaya ongoing medical or dental treatment that could interfere with the results.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Carica Papaya extract<br>Carica Papaya at 3% | Other: CARICA PAPAYA MOUTHWASH<br>* Each application was 10 ml. applied for 1 minute, once a day for 8 days<br>|
| Active Comparator: Chlorhexidine<br>0.12% chlorhexidine mouthwash formulation (commercially available) | Other: CHLORHEXIDINE MOUTHWASH<br>* Each application was 10 ml. applied for 1 minute, once a day for 8 days<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of Colony Forming units (Stage 1) | Before Intervention | thorough study completion, an average of 24 hours | 
| Number of Colony Forming units (Stage 2) | After Intervention | 10 minutes after mouthwash use | 
| Number of Colony Forming units (Stage 3) | After Intervention | 8 days after mouthwash use | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Saliva, dental plaque, streptococcus mutans