Message Framing on Recruiting Rh-D Negative Blood Donors

Study Overview
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Brief Summary
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Rh negative blood group is a rare blood group in China, as it only accounts for 0.3-0.4 percent of the Han population. Therefore, low inventory is often found in blood collection and supply agencies in many regions in China. On July 22, 2020 blood stockpile of O-negative and A-negative in Guangzhou Blood Center reached the warning line, and we took measures for emergency recruitment. O-negative and A-negative blood donors whose last donation dates were between January 1, 2018 and December 31, 2019 were identified and randomly assigned to four groups. Three different recruitment text messages were send three groups. We observed the re-donation rates among four groups within one week.

Official Title
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Effects of Message Framing on Recruiting Rh-D Negative Blood Donors in an Emergency Situation

Conditions
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Blood Donation

Intervention / Treatment
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* Other: Gain-framed SMS message
* Other: Loss-framed SMS message
* Other: Information SMS message


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: - O and A Rh- negative blood donors Last donations were between January 1, 2018 and December 31, 2019 Exclusion Criteria: - With an obviously invalid phone number Serological results of the last donation were positive

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Gain-frame Message<br>Short messaging service (SMS) message: Dear group O/A Rh-D negative blood donor: Hello! The inventory of group O/A Rh-D negative blood product is low at present, but patients with such blood group are in urgent need of blood. If you can, please consider donating blood again to save lives. Thank you for your support. Please bring your identification (ID) card and show this message to our staff. Thank you. | Other: Gain-framed SMS message<br>* Emergency recruitment cell phone short messages that emphasizing donating blood can save patients' lives were sent to donors in this group.<br>|
| Experimental: Loss-frame Message<br>SMS message: Dear group O/A Rh-D negative blood donor: Hello! The inventory of group O/A Rh-D negative blood product is low at present, but patients with such blood group are in urgent need of blood. If you can, please consider donating blood again to prevent the loss of life. Thank you for your support. Please bring your ID card and show this message to our staff. Thank you. | Other: Loss-framed SMS message<br>* Emergency recruitment cell phone short messages emphasizing that donating blood can prevent patients from death were sent to donors in this group.<br>|
| Experimental: Information Message<br>SMS message: Dear group O/A Rh-D negative blood donor: Hello! The inventory of group O/A Rh-D negative blood product is low at present, if you can, please consider donating blood again. Thank you for your support. Please bring your ID card and show this message to our staff. Thank you. | Other: Information SMS message<br>* Emergency recruitment cell phone short messages that only mentioning the low Rh-negative blood stockpile were sent to donors in this group.<br>|
| No Intervention: Control group<br>Donors in this group were not received SMS reminders. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Re-donation rate | Intention-to-treat were applied. Re-donation rate was defined as the number of donors in each group divided by donors who re-donated within 7 days. | 7 days |