Canderel:Effects on Blood Glucose Concentration and Appetite Scores

Study Overview
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Brief Summary
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This study investigates the effects of Canderel, an aspartame and acesulfame-k blend artificial sweetener powder, on post-postprandial blood glucose levels and appetite scores.

Detailed Description
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The study is separated into two parts: A) investigating the effects of artificial sweeteners in combination with complex carbohydrates; and B) investigating the effects of artificial sweeteners in combination with simple sugars. A) Participants will be randomly given either the placebo drink (3g of maltodextrin dissolved in 250ml of water) or the Canderel drink (3g of Canderel dissolved in 250ml of water) alongside an isocaloric high carbohydrate breakfast. Blood glucose measurements will be obtained through finger pricking and appetite will be measured using self-reported visual analog scores rating hunger, desire to eat, fullness and alertness for up to 3 hours after breakfast. B)Participants will be randomly given either the placebo drink (3g of Lyle's Golden syrup and 3g of maltodextrin dissolved in 250ml of water) or the Canderel+sugars drink (3g of Canderel and 3g of Lyle's Golden syrup dissolved in 250ml of water) . Blood glucose measurements will be obtained through finger pricking and appetite will be measured using self-reported visual analog scores rating hunger, desire to eat, fullness and alertness for up to 3 hours after drink

Official Title
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The Effects of Canderel (Aspartame and Acesulfame-k Blend) on Blood Glucose Concentration and Appetite Scores in Humans: a Randomised Controlled Trial

Conditions
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Appetitive Behavior, Glucose Metabolism Disorders

Intervention / Treatment
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* Dietary Supplement: Canderel drink
* Dietary Supplement: Canderel+Lyle's Golden Syrup drink


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy male and female adults (18-64) Exclusion Criteria: -

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 64 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Experiment A- experimental<br>3g Canderel in 250ml water | Dietary Supplement: Canderel drink<br>* 1.4% aspartame and 0.95% acesulfame-k and 95% maltodextrin; 3g dissolved in 250ml of water<br>|
| No Intervention: Experiment A- control<br>3g of maltodextrin in 250 ml of water | |
| Experimental: Experiment B- experimental<br>3g Canderel + 35g Lyle's Golden Syrup in 250 ml water | Dietary Supplement: Canderel+Lyle's Golden Syrup drink<br>* Canderel: 1.4% aspartame and 0.95% acesulfame-k and 95% maltodextrin; 3g dissolved in 250ml of water Lyle's Golden Syrup: 35 g (27g of glucose and fructose)<br>|
| No Intervention: Experiment B- control<br>3g Lyle's Golden Syrup + 35g of maltodextrin in 250 ml of water | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Blood glucose | Capillary blood obtained from fingerprick and measured using glucose monitor | 0-180min (Measured from baseline to 90min every 15min; 90-180min every 30min) | 
| Change in Appetite | Feelings of hunger, desire to eat, fullness and alertness measured using Visual Analog Scale (VAS) | 0-180min (Measured from baseline to 90min every 15min; 90-180min every 30min) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Blood glucose, Appetite