TAES Improve the Function of Respiration and Circulation on Elderly Patients Undergoing Colonoscopy Procedure

Study Overview
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Brief Summary
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To explore the effectiveness of transcutaneous acupuncture electrical stimulation (TAES), a non-invasive modality in improvement of the function of respiration and circulation on elder patient during colonoscopy.

Detailed Description
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To assess the function of respiratory and circulation before precondition, during colonoscopy and end of the procedure, blood cortisol and catecholamine levels were measured also.The incidence of airway support, application of vasoactive drug or atropine during procedure were recorded in the meantime.

Official Title
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Transcutaneous Acupoint Electrical Stimulation Improve the Function of Respiration and Circulation on Elderly Patients Undergoing Colonoscopy Procedure：A Randomized-controlled Trial

Conditions
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Respiratory Depression

Intervention / Treatment
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* Device: TAES


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients aged 65 or older American Society of Anesthesiologists (ASA) grade I II consent and voluntary participation in this experiment patients under colonoscopy none allergic to propofol and fentanyl airway assessment for none difficult airway Exclusion Criteria: Allergic to propofol, fentanyl. ASA is greater than or equal to grade 3 Abnormal respiratory tract may cause severe respiratory obstruction unsatisfactory control of hypertension, systolic pressure over 160 millimeter of mercury (mmHg) or diastolic pressure over 100 mmHg Hypotension, systolic pressure below 90 mmHg, heart rate (HR) <50bpm or >100bpm

Ages Eligible for Study
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Minimum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Group 1 sedation group<br>Elderly patients under colonoscopy with sedation, but no real TAES neiguan(pc6) sedation is using the typical protocol for the following: Slowly peripheral intravenous injection(0.5ml/s) of fentanyl 50μg, then followed with 1.5-2.5mg/kg propofol until loss of eyelash reflex, the Observer's Assessment of Alertness/Sedation Scale (OAAS) score Level3-5. | Device: TAES<br>* TAES over acupuncture point neiguan (pericardium 6) for 20min, placebo group only stick the stimulate electrode but no frequency and intensity<br>|
| Experimental: Group 2 sedation+TAES group<br>Elderly patients under colonoscopy both have TAES neiguan(pc6) and sedation. sedation is begun followed TAES. sedation is same as group2 do. TAES is same as group3 do. | Device: TAES<br>* TAES over acupuncture point neiguan (pericardium 6) for 20min, placebo group only stick the stimulate electrode but no frequency and intensity<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The percentage of oxygen saturation | The percentage of oxygen saturation between the sedation alone and sedation+TAES have at least 2 difference | from 20min before lay down to 24hours after performance |