Application of Serial Body Composition Change for Risk Prediction in Treating Patients With Severe Pneumonia

Study Overview
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Brief Summary
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We hypothesize that serial changes of body composition in patients with pneumonia can help clinician to monitor prognosis. It was associated with underlying immune response.

Detailed Description
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Specific aims: Can serial body composition data be useful for predicting outcomes of patients with pneumonia? (developing sepsis, organ failure, admission to ICU, length of ICU, survival, length of stay in hospital, prolonged mechanical ventilation,..) Can serial body composition data be integrated into both immune status alternatives (e.g., white blood cell (WBC) count, segment/monocyte ratio, pulse pressure) in such critical illness and monitoring responses (SOFA score, labs) for severe pneumonia patients? Can serial body composition data reflect clinical variables in patients with pneumonia, and even altered by nutrition intake? (e.g., compare association between nutrition intake amount and groups stratified by body composition, blood pressure, nutritional intake, …)

Official Title
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Application of Serial Body Composition Change for Risk Prediction in Treating Patients With Severe Pneumonia

Conditions
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Pneumonia

Intervention / Treatment
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* Device: noninvasively Bio-electrical Impedance Analysis (BIA)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adult patients with pneumonia admitted to the thoracic ward or medical intensive care unit of Kaohsiung Chang Gung Memorial Hospital Exclusion Criteria: -

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: noninvasively Bio-electrical Impedance Analysis (BIA)|By means of noninvasively Bio-electrical Impedance Analysis (BIA) to measure body composition, which divides body weight into different components such as lean body mass and fat mass.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| ICU Days | length of stay in ICU | During hospitalization， through study completion, an average of 1 year | 
| Ventilation days | days of mechanical ventilation | up to 24 weeks | 
| sepsis free days | the cure day of sepsis | up to 24 weeks | 
| mortality | death rate | During hospitalization， through study completion, an average of 1 year | 
| Change in Total Body Water | Change in Total Body Water | Change from Baseline Total Body Water at day 8 | 
| Change in Percentage of Body Fat | Change in Percentage of Body Fat | Change from Baseline Percentage of Body Fat at day 8 | 
| Change in Soft Lean Mass | Change in Soft Lean Mass | Change from Baseline Soft Lean Mass at day 8 | 
| Change in segment/monocyte ratio | Change in Segment count to monocyte count ratio | Change from Baseline Segment count to monocyte count ratio at day 8 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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pneumonia, sepsis, body composition