Observational Study of the Impact of Genetic Testing on Healthcare Decisions and Care in Interventional Pain Management

Study Overview
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Brief Summary
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The purpose of this study is to evaluate the impact of genetic testing on healthcare decisions and patient outcomes in interventional pain management clinical care. Results of genetic testing will also be compared with the clinical outcome measures collected to discover novel genetic factors that may influence patient care.

Detailed Description
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Specific genetic variations have been identified that result in alteration of expression or function of receptors, enzymes, and transporters that are relevant to the safety and efficacy of a medical treatment. By providing information regarding the genetic risks and the most effective therapy for an individual patient, clinicians may improve the efficacy of treatment and decrease the risk of adverse events. The purpose of this study is to evaluate how currently available genetic tests are being implemented in various interventional pain management clinics around the United States, and whether this information results in benefits to patient care. Considering patient genotype correlates with pain sensitivity and perception, as well as autonomic nervous system dysfunction due to variations in sodium and potassium channels, genotypic associations can significantly improve outcomes in interventional pain management modalities including: Injections (also called nerve blocks using medications), such as steroids and opioids, including epidural steroid injections, facet joint injections, single nerve root blocks, and sacroiliac joint injections; Radiofrequency Rhizotomy (radiofrequency ablation and neuroablation), using x-ray guidance and a needle with an electrode at the tip that gets heated, to temporarily turn off a nerve's ability to send pain messages to the brain; and, Intrathecal pump implants which provide potent medications straight to the source of pain. Patient that are receiving Proove Bioscience's genetic testing will complete validated questionnaires to measure specific outcomes related to their treatment at each clinical visit, including medication efficacy, reduction in adverse drug events, and healthcare utilization. Physicians will document any changes made to treatment regimens, including adjustments to medications or non-pharmacological treatments, and any improvements in the outcome measures. Statistical analysis will be performed to calculate relationships between genotypic and phenotypic data points collected in this study. The results of this study will provide a measurable understanding of the medical and economic value of implementing genetic testing into interventional pain management. Furthermore, data points collected will be used to examine novel correlations and associations between single nucleotide polymorphisms and longitudinal clinical outcome measures.

Official Title
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A Multicenter Longitudinal Observational Study Evaluating Genotypic Association wIth Clinical Outcomes in Interventional Pain Management Modalities

Conditions
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Pain, Chronic Pain, Back Pain, Nociceptive Pain, Neuropathic Pain, Musculoskeletal Pain, Neck Pain, Pain, Intractable

Intervention / Treatment
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* Other: Observational


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Provide signed and dated informed consent form Willing to comply with all study procedures and be available for the duration of the study Male or Female, at least 18 years of age Currently taking or a candidate for opioid pain medication Documented or recent complaint of pain within 90 days (location to be documented in the case report form) with initial date of onset Exclusion Criteria: Severe hepatic or renal disease (where current pharmaceutical dosing is affected and/or requires adjustment of standard dosing prior to PGx testing) Significant diminished mental capacity that is unable to understand the protocol, surveys and questionnaires; unable to read/write English or Spanish. Recent febrile illness that precludes or delays participation by more than 1 month Pregnancy or lactation Participation in a clinical study that may interfere with participation in this study Anything that would place the individual at increased risk or preclude the individual's full compliance with or completion of the study

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Pain patients<br>Observational; Patients presenting to interventional pain management centers for therapy. | Other: Observational<br>* This study will evaluate the impact of genetic testing information on medical regimen plans and whether this information results in benefits to patient care.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain Scores on the Pain Numeric Rating Scale (NRS) |  | 60 days | 
| Function/Disability assessment on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) |  | 60 days | 
| Number of Participants that Experience of Adverse Events |  | Up to 2 years | 
| Type of Adverse Events Experienced by Participants |  | Up to 2 years | 
| Severity of Adverse Events Experienced by Participants |  | Up to 2 years | 
| Type of treatments selected for participants |  | 60 days | 
| Medication dosage prescribed to the participants |  | 60 days | 
| Frequency of participant urine drug screens |  | 60 days | 
| Self-rated response levels to prescribed medications |  | 60 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Co-occurring disorders reported by ICD-9/10 code |  | 60 days | 
| Assessment of previous treatments |  | 60 days | 
| Urine drug screen results |  | 60 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Pain Management, Genetic Variation, Genetic Polymorphism, Polymorphism, Single Nucleotide Genetic Association Studies, Healthcare Utilization