Negative Postprandial Effect on Endothelium After a Not-healthy Meal in Type 2 Diabetes as Affected by Training

Study Overview
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Brief Summary
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The purpose of this study is to examine whether exercise reduces the postprandial effects of an unhealthy meal on heart function and endothelial function. Both healthy people and type 2 diabetes subjects will during three days either carry out two different sessions of exercise training or not before ingesting an unhealthy meal high in saturated fat and fast carbohydrates. The two different exercise training modes used are high intensity interval training (HIIT) and moderate intensity training (MIT) Hypothesis: Exercise training in advance of an unhealthy meal will improve endothelial- and cardiac function in healthy and type 2 diabetes individuals. HIIT will reduce the negative postprandial effects on the endothelium more than MIT.

Official Title
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Negative Postprandial Effect on Endothelium After a Not-healthy Meal in Type 2 Diabetes as Affected by Training

Conditions
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Diabetes Mellitus, Type 2

Intervention / Treatment
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* Behavioral: 47 min moderate intensity training
* Behavioral: exercise healthy volunteers
* Behavioral: control; no exercise training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: healthy or type 2 diabetes Exclusion Criteria: type 2 diabetes more than 10 years unstable angina myocardial infarction overt cardiovascular disease. severe valvular disease. overt lung disease. orthopedical- /neurological restrictions severe disease related to diabetes type 2 (neuropathy, micro-or macroalbuminuria, retinopathy) body mass index >35 severe eating disorders. personality disturbances. planned surgery during the project period. patients who achieve greater than the current exercise guidelines for type 2 diabetes (210 min/week) before the start of the study. uncontrolled hypertension kidney failure cardiomyopathy smoking patients who probably not will be able to complete the study alcohol or drug abuse

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: exercise diabetes type 2<br>4x4 min interval training, 47 min moderate intensity training, or no exercise preceding an 'unhealthy' meal. | Behavioral: 47 min moderate intensity training<br> <br> Behavioral: exercise healthy volunteers<br> <br> Behavioral: control; no exercise training<br> <br> |
| Active Comparator: exercise healthy volunteers<br>4x4 min interval training, 47 min moderate intensity training, or no exercise preceding an 'unhealthy' meal. | Behavioral: 47 min moderate intensity training<br> <br> Behavioral: exercise healthy volunteers<br> <br> Behavioral: control; no exercise training<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| endothelial function | measured as flow mediated dilatation (FMD) of the brachial artery using high resolution vascular ultrasound according to current guidelines | 24 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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exercise, endothelium, postprandial period