Genetic and Neural Factors in Alcohol-Related Cognition

Study Overview
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Brief Summary
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This study is about how genetic and brain factors impact cognitive processes and behavior after alcohol consumption. Participation in this project will contribute to a better understanding of biological factors that influence alcohol misuse. This study will be completed in two laboratory visits.

Detailed Description
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Some study details are purposely omitted at this time to preserve scientific integrity. Full details will be posted at the conclusion of the study.

Official Title
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Genetic and Neural Factors in Alcohol-Related Cognition

Conditions
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Alcohol Abuse

Intervention / Treatment
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* Behavioral: MRI Scanner


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: English speaking No current or regular use of prescribed or illicit psychoactive drugs Free of major health problems (e.g., diabetes, HIV, Parkinson's disease) Free of a neurological or psychiatric disorders No current drug abuse (e.g., recreational drug use). Right hand dominant Free of claustrophobia Free of pregnancy or suspected pregnancy Absent MRI risk factors (e.g., implanted medical device, body mass index > 35, braces) Free of medical conditions that render individuals with overly sensitive hearing Non-naive to alcohol consumption Exclusion Criteria: Not meeting inclusion criteria listed above

Ages Eligible for Study
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Minimum Age: 21 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Alcohol Group<br>Participants who have recently consumed alcohol. | Behavioral: MRI Scanner<br>* Participants will enter the MRI scanner and complete a series of computer tasks that include noise blasts while undergoing brain scans that measure the structure and function of the brain<br>|
| Sham Comparator: No Alcohol Group<br>Participants who have not recently consumed alcohol. | Behavioral: MRI Scanner<br>* Participants will enter the MRI scanner and complete a series of computer tasks that include noise blasts while undergoing brain scans that measure the structure and function of the brain<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in alcohol-influenced behavior | Competitive reaction-time behavior after recent consumption of an alcoholic beverages (versus without recent consumption of an alcoholic beverages) will be measured using the validated and computerized Taylor Competitive Reaction-Time Task. Some outcome measure details are purposely omitted at this time to preserve scientific integrity. | Approximately 7 days between alcohol consumption. |