Acute Coronary Disease (ACS)- Strain

Study Overview
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Brief Summary
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Examination of probable distinction between cardiac or non- cardiac thoracal disorder via echocardiographic myocardial strain analysis

Detailed Description
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Patients with cardiac disorder have to undergo time- consuming and expensive examinations such as laboratory of cardiac biomarkers or ischemic diagnostic. To save time and money in this observational registry the probable distinction between cardiac and non- cardiac disorder in patients with vague thoracal disorder and the probability for coronary artery disease (determined via Grace Score) is examined via echographic myocardial strain analysis in 300 patients retrospectively to establish a cut off value corresponding to acute coronary disease also to prevent coronary angiography. Therefore patients undergo echography routinely with consecutive evaluation of systolic, diastolic and strain analysis to elevate exact statements with reference to deformation of the myocard and its velocity. Several study have shown that these strain parameters (circumferential and radial strain) enable vitality and ischemic diagnosis and therefore could be eligible for this purpose.

Official Title
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Analysis of Myocardial Deformation in Patients With Acute Coronary Disease

Conditions
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Cardiac and Non Cardiac Thoracal Disorder

Intervention / Treatment
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* Other: retrospective echographic myocardial strain analysis refering to acute coronary syndrome


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: thoracal cardiac or non cardiac disorder signed informed consent Exclusion Criteria: glomerular filtration rate (GFR) < 60 ml/min angina pectoris acute myocardial infarction within 3 months prior inclusion pregnancy

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with thoracal disorder<br>300 patients with thoracal disorder, cardiac or non- cardiac, are enrolled prospectively to undergo routinely examinations such as clinical and hemodynamic chemistry as well as echocardiography for strain analysis refering to myocardial deformation. Especially analysis of strain data (circumferential and radial), regional and global left and right ventricular wall movement data and diastolic parameters will be analysed retrospectively to investigate a probable cut off value corresponding to acute coronary disease or non cardiac disorder (Intervention: retrospective echographic myocardial strain analysis refering to acute coronary syndrome). | Other: retrospective echographic myocardial strain analysis refering to acute coronary syndrome<br>* retrospective evaluation for cut off value of circumferential and radial echographic strain parameters corresponding to acute coronary disease<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Determination of cut off value of circumferential and radial myocardial echographic strain data corresponding to acute coronary disease |  | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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acute coronary disease, echographic strain analysis, cut off