linjc16/ctgov huggingface dataset:
Egg Donor Recipient Characteristics Preferences

Study Overview
=================
Brief Summary
-----------------
To identify the characteristics in an egg donor that are important to a recipient and to see if those characteristics change over time.

Detailed Description
-----------------
No study has explored how recipients' attitudes and reactions change over time regarding the selection criteria for their donors. Consequently, programs have no guidance in how to counsel prospective recipients as to whether their donor preferences will change over time. Participants will complete a survey at 4 points in time as they go through the process of selecting an egg donor and pursuing a pregnancy using that egg donor.

Official Title
-----------------
Do Egg Donor Recipient Characteristics Change Over Time?

Conditions
-----------------
Egg Donor Recipient Characteristics

Participation Criteria
=================
Eligibility Criteria
-----------------
All patients planning to undergo an egg donor cycle are eligible- there are no specific inclusion or exclusion criteria beyond that.

Ages Eligible for Study
-----------------
Minimum Age: 21 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Egg donor recipients<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Characteristics of Donors | To identify the characteristics of donors which are important to recipients and whether their importance changes over time. | duration of study | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
egg donor, recipients, donor characteristics
A Quality of Life Study in Patients With Migraines

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to compare depressive characteristics in migraine patients to those observed in patients with epilepsy in a previous study, and determine whether those symptoms are unique to patients with epilepsy.

Detailed Description
-----------------
A form of depression known as dysphoric-like disorder is common in people with epilepsy, which may significantly affect the quality of life in these people, as shown in a previous study. However, it is unclear if this depressive disorder is unique to patients with epilepsy. In order to assess whether these symptoms are unique and idiosyncratic to the epilepsy population, in this multi-center study, these dysphoric depressive features will be contrasted to those seen in patients with other neurologic or psychiatric conditions. Migraine is selected as one of the comparison disorders because it shares with epilepsy characteristics of being a recurrent episodic central nervous system disorder, and our site will only enroll patients with migraine headaches.

Official Title
-----------------
Dysphoric-like Disorder of Epilepsy, Is It Unique?

Conditions
-----------------
Migraine, Headache, Depression

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Male or female 18 years of age or older Have the diagnosis of migraine Have had no change in migraine medication(s) 30 days prior to study Achieve a satisfactory score on the Wide Range Achievement Test 3 (WRAT3) test at the screening visit Capable of completing self-reporting questionnaires Willing and able to provide written informed consent and comply with the study protocol Exclusion Criteria: Presence of a clinically significant comorbidity of an unstable or progressive nature Presence of major depression Participation in an investigational drug study within the past 30 days Inability to communicate well with site study personnel

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Dysphoric-like depressive characteristics in patient with epilepsy |  | N/A (cross-sectional study) | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Migraine, Headache, Depression, Quality of Life
Fatty Acid Levels and Memory in Breastfed Children

Study Overview
=================
Brief Summary
-----------------
Purpose: To explore the relation between breastmilk nutrients and the cognitive abilities of breastfed infants. Phase 1: Near 3 months of age child and mother saliva samples for DNA obtained with breast milk sample. Phase 2: At 6 months of age child participates in electrophysiology session to test recognition memory. Phase 3: At 26 or 38 months of age, children will complete behavioral, dietary, and physical assessments.

Official Title
-----------------
The Influence of FADS2 rs 174575 on Breastmilk Fatty Acid Levels and the Recognition Memory Abilities of 6-month Old Breastfed Infants and Follow-up

Conditions
-----------------
Cognitive Development

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: typically-developing exclusively breastfed unremarkable delivery Exclusion Criteria: non-English speaking history of seizure activity

Ages Eligible for Study
-----------------
Minimum Age: 3 Months
Maximum Age: 4 Months

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Relation between recognition memory and maternal FADS genotype | At 6 months of age, during the second session (Phase 2) | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Nutrient content of breastmilk as it relates to FADS genotype | Sample provided in session 1 when the infant was 3-4 months old (Phase 1) | 3 to 4 months | 
| Nutrient content of breastmilk as it relates to recognition memory | At 6 months of age, during the second session (Phase 2) | 6 months | 
| Relation between declarative memory and breastmilk nutrients | At session 3, when the child was either 26 or 38 months of age (Phase 3) | 26 or 38 months | 
| Relation between declarative memory and concurrent nutrients | At session 3, when the child was either 26 or 38 months of age (Phase 3) | 26 or 38 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Breast milk nutrients, Cognitive development, Electrophysiology, Long-term assessment, Fatty acids
Metabolic Exercise Testing

Study Overview
=================
Brief Summary
-----------------
Exertional symptoms are the hallmarks of metabolic myopathies, supporting the concept of using functional tests when this diagnosis is suspected. Exercise increases the concentration of muscle metabolites in the venous blood supply (e.g. lactate, pyruvate, and ammonia) especially during recovery. The purpose of this study is to compare the results of exercise testing with to the data from muscle biopsy or genetic analysis.

Official Title
-----------------
Exercise Testing in Metabolic Myopathies

Conditions
-----------------
Metabolic Myopathies, Exercise Test, Myalgia

Intervention / Treatment
-----------------
* Device: functional test
* Genetic: matching genotype with phenotype


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Referred to the Physiology Department of Brest Hospital for a metabolic exercise test Ability to provide informed consent Exclusion Criteria: Contraindication(s) to perform cardiopulmonary exercise testing (ATS/ACCP statement on cardiopulmonary exercise testing, Am J respi Care Med 167: 211-77, 2003) Pregnancy or unknown pregnancy status.

Ages Eligible for Study
-----------------
Minimum Age: 5 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| metabolic exercise testing<br>All the subjects referred to performed a metabolic exercise testing. | Device: functional test<br>* subjects perform a metabolic exercise testing<br>Genetic: matching genotype with phenotype<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Whole-body dynamic exercise | The relation between Cardiopulmonary exercise test variables and the results of muscle biopsy or genetic analysis will be evaluated. | Participants will be followed for an expected average of 1 year to determine whether a muscle biopsy is performed | 
| Grip-test | The relation between Grip-test variables and the results of muscle biopsy or genetic analysis will be evaluated. | Participants will be followed for an expected average of 1 year to determine whether a muscle biopsy is performed | 
| Blood tests | The results of blood analysis from samples performed before, during, and after exercise will be compared to the results of muscle biopsy or genetic analysis. | Participants will be followed for an expected average of 1 year to determine whether a muscle biopsy is performed | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Grip-test, Metabolic myopathies, Exercise testing, Blood sample, Muscle biopsy, Genetic analysis, Cycloergometer, Exercise physiology, Muscle physiology
Short Term Growth in Children With Atopic Dermatitis

Study Overview
=================
Brief Summary
-----------------
Main objective:to assess short term growth in children with atopic dermatitis during treatment with tacrolimus 0.1% and mometasone furoate 0.1%. A singl blind randomised cross over trial including 20 children. The study consists of 5 periods: run in, treatment(1),wash out, treatment(2) and run out. Each period 14 days where the children will use tacrolimus ointment tvice daily, mometasone furoate once daily or moisturizer (in run in wash out and run out)

Conditions
-----------------
Atopic Dermatitis

Intervention / Treatment
-----------------
* Drug: tacrolimus ointment 0.1%
* Drug: mometasone furoate 0.1%


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age 5-14, atopic dermatitis, normal current growth, Tanner 1, informed consent by the parent or guardian, willing and able to comply with study procedures Exclusion Criteria: Tanner 2-5, treatment of atopic dermatitis with anti-inflammatory agent within 1 week before the first visit, current asthma or rhinoconjunctivitis that requires treatment with glucocorticoids, endocrine diseases, major surgery within 4 weeks prior to visit 1, fever >39.5 for >3 days

Ages Eligible for Study
-----------------
Minimum Age: 5 Years
Maximum Age: 14 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: tacrolimus ointment 0.1%|nan|
|Drug: mometasone furoate 0.1%|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| short term growth during treatment compared to run in |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| U-EPX |  |  | 
| U-nTX |  |  | 
| skin prick test |  |  |
The Most Frequently Preferred Surgical Method In The Treatment Of Sacrococcygeal Pilonidal Disease

Study Overview
=================
Brief Summary
-----------------
There is no consensus on which procedure is the ideal surgical method in the treatment of sacrococcygeal pilonidal disease (SPD). The study aimed to retrospectively screen the cases that had undergone surgical treatment for SPD in the last 15 years in four different tertiary Stage hospitals and analyze the most frequently used surgical treatment method and its results.

Detailed Description
-----------------
The researchers in our study will retrospectively scan the records of patients who have been operated on for SPD in the last 15 years at Health Sciences University Konya Health Practice and Research Center, Selçuk University Medical Faculty Hospital, Necmettin Erbakan University Medical Faculty Hospital, and Başkent University Medical Faculty Hospital General Surgery Clinics. Demographic characteristics of the patients, type of anesthesia, duration of operation, duration of hospitalization, time to return to work or school, final healing time, follow-up time, and recurrence information will be transferred to the SPSS statistics program analyzed. The researchers could not find any articles in the literature on the subject. Therefore, this study will contribute to the literature.

Official Title
-----------------
The Most Frequently Preferred Surgical Method In The Treatment Of Sacrococcygeal Pilonidal Disease; Multicenter Cohort Study

Conditions
-----------------
Pilonidal Sinus

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All patients between the ages of 14-80 who underwent surgery for pilonidal sinus Exclusion Criteria: unregulated diabetes mellitus collagen tissue disease decompensated cardiovascular disease cases with missing follow-up information

Ages Eligible for Study
-----------------
Minimum Age: 14 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Type of surgery method | The ratio of each type of surgery to the study population | 15 day | 
| duration of surgery | The average operation time of the determined types of surgery will be determined. | 15 day | 
| hospitalization time | The average hospitalization time of the determined types of surgery will be determined. | 15 day | 
| Type of anesthesia | the ratio of anesthesia methods to the study population | 15 day | 
| day time return to work | return to work time will be found as average days for specified surgery types. | 15 days | 
| complete healing time | Complete healing time will be found as average days for specified surgery types | 15 days | 
| recurrence | recurrence rate in the study population | 15 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
pilonidal, surgery, healing
Surgical Outcome of Type II Odontoid Fracture, Harms Technique

Study Overview
=================
Brief Summary
-----------------
Cervical trauma is a common cause of disability following spinal cord injury, especially in athletic populations. The biomechanics in the atlantoaxial joint carry more than 50% of the rotational movement which can be affected in transverse ligament tear associated with odontoid fracture type II. Odontoid fracture type II considered an unstable fracture with a high rate of non-union in conservative treatment. Limitation of the odontoid screws in some cases gives the chance of posterior cervical fixation to have the superior role. Use of polyaxial screws in Harms technique gives the best results in maintaining the majority of the biomechanics. Purpose: our aim in this study to evaluate Harms technique in those patients regarding pain improvement and restoration of the motor power and to report the complications. Study design: A retrospective case series study. We Used the Frankel grading system to evaluate the postoperative neurological state.

Detailed Description
-----------------
After approval of Research Ethics Committee, twelve patients with post-traumatic odontoid fracture type II were scheduled in our Neurosurgery department at Sohag University Hospital for atlantoaxial fusion using polyaxial C1 lateral mass and C2 pedicle screws between January 2015 and January 2018.

Official Title
-----------------
Surgical Outcome of Type II Odontoid Fracture, Harms Technique

Conditions
-----------------
Tramatic Odontoid Fracture

Intervention / Treatment
-----------------
* Procedure: Harms technique


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: C1-C2 displacement that needs intra-operative reduction Short neck not suitable for anterior odontoid screw Osteoporotic patients Odontoid fracture associated with transverse ligament tear suspected. Oblique line of fracture Failure of union after conservative treatment. Exclusion Criteria: Associated spinal fractures Other comorbidities

Ages Eligible for Study
-----------------
Minimum Age: 16 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: traumatic odontoid fracture<br>C1 C2 fusion screws | Procedure: Harms technique<br>* Atlantoaxial fusion<br>* Other names: C1 C2 fusion;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| evaluation neurological deficit using Frankel grading system within 3 years | grades from A to E and A is the best neurological function while E is the worst neurological function | 3 years |
The Study of Abatacept in Combination With Etanercept

Study Overview
=================
Brief Summary
-----------------
The Study was designed to look at the safety and efficacy of abatacept in combination with etanercept.

Official Title
-----------------
A Multi-Center, Randomized, Double-Blind, Placebo Controlled Study to Evaluate the Safety and Clinical Efficacy of Intravenous Infusions of BMS-188667 (10 mg/kg) Given Monthly in Combination With Subcutaneous Injections of Etanercept (25mg)Given Twice Weekly to Subjects With Active Rheumatoid Arthritis

Conditions
-----------------
Rheumatoid Arthritis

Intervention / Treatment
-----------------
* Drug: Abatacept


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All subjects who had completed the short term portion of IM101-101.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Abatacept|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Abatacept combined with etanercept will have greater clinical efficacy compared to subjects receiving etanercept alone |  | at 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| ACR 50 and 70 will be evaluated |  | at 6 months |
Evaluation of Tele-expertise for Inmates With a Dermatological Lesion

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine whether Tele-expertise would be effective and cost-effective by reducing the number of secure transportations for inmates in need of a dermatological consultation

Official Title
-----------------
Evaluation of Tele-expertise for Inmates With a Dermatological Lesion

Conditions
-----------------
Skin Disease

Intervention / Treatment
-----------------
* Device: Telemedicine


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Dermatological expertise required Exclusion Criteria: None

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Control group before telemedicine<br>Inmates of prisons not having telemedicine before implementation of telemedicine in prisons having telemedicine | |
| Control group after telemedicine<br>Inmates of prisons not having telemedicine after implementation of telemedicine in prisons having telemedicine | |
| Exposed group, before telemedicine<br>Inmates of prisons having telemedicine before implementation of telemedicine | |
| Exposed group, after telemedicine<br>Inmates of prisons having telemedicine after implementation of telemedicine | Device: Telemedicine<br>* Inmates of prisons having telemedicine after implementation of telemedicine<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Proportion of a dermatological expertise among those required |  | 1 month after the end of the study | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of hospitalizations for a dermatological reason |  | 1 month after the end of the study | 
| Overall costs |  | 6 months after the end of the study | 
| Time to a dermatological expertise |  | 1 month after the end of the study | 
| Number of usual consultations needed after Tele-expertise |  | 1 month after the end of the study | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
inmates, skin lesion, telemedicine