Mycological Comparative Study on Maxillary Dentures of Two Different Materials

Study Overview
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Brief Summary
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Cross over design the investigator divide participants to two groups group (A) will receive rapid heat cured denture base material and group (b) will receive the acrylic denture modified by titanium dioxide nanoparticles and after washout period alternatively group (a) will receive the acrylic denture modified by titanium dioxide nanoparticles AND group (b) will receive rapid heat cured denture base material the investigator will take swaps from dentures to count the candida species

Official Title
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Mycological Comparative Study Between Single Maxillary Denture Fabricated From Rapid Heat Cure Acrylic Resin Material and Conventional Acrylic Resin Material Modified by Titanium Dioxide Nanoparticles

Conditions
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Effect of Tio2 Nanoparticles on Candida Aggregation

Intervention / Treatment
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* Other: titanium dioxide denture


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Completely edentulous maxillary arch and partially dentate mandibular arch with adequate interarch space. The edentulous ridges should be covered by firm healthy mucosa. Angle class I maxillomandibular relation. Healthy and cooperative patient Exclusion Criteria: Patients with bad habits as severe clenching or bruxism, drug or alcohol addiction, moderate or heavy smoking (greater than 10 cigarettes per day). Previous history of radiotherapy or chemotherapy. Any skeletal problem dictates surgical intervention

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 55 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: patients take titanium dioxide denture<br>patients will receive titanium dioxide denture (made from conventional acrylic resin modified by titanium dioxide nanoparticles ) for 1 month in the initial phase of the trial then in the later phase after one month they will receive( rapid heat cured acrylic resin)denture | Other: titanium dioxide denture<br>* patients will receive titanium dioxide denture (made from acrylic resin with titanium dioxide nanoparticles ) for 1 month in the initial phase then in the second phase after one month they will receive( rapid heat cured acrylic resin)denture according to the principle of crossover des<br>|
| Placebo Comparator: patients take rapid heat denture<br>patients will receive rapid heat denture for 1 month in the initial phase of the trial then in the later phase patients will receive titanium dioxide denture (made from conventional acrylic resin modified by titanium dioxide nanoparticles ) | Other: titanium dioxide denture<br>* patients will receive titanium dioxide denture (made from acrylic resin with titanium dioxide nanoparticles ) for 1 month in the initial phase then in the second phase after one month they will receive( rapid heat cured acrylic resin)denture according to the principle of crossover des<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mycological investigation | Count of candida on the fitting surface of denture by (CFU) unit | 6 months |