Study to Compare Standard Perimetry With the New Scotoma-Oriented Perimetry (SCOPE) Using a New Fast German Adaptive Threshold Estimation (GATE) in Glaucoma Patients

Study Overview
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Brief Summary
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The purpose of this study is to compare the two psychophysical perimetric techniques regarding progression of the visual field.

Official Title
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Pilot Study to Compare the Humphrey Field Analyzer (HFA) 30-2 Swedish Interactive Threshold Algorithm (SITA) Standard Perimetry With the New Scotoma-Oriented Perimetry (SCOPE), Using a New Fast GATE (German Adaptive Threshold Estimation) in Glaucoma Patients Under Topic Therapy

Conditions
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Primary Open Angle Glaucoma (POAG)

Intervention / Treatment
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* Device: Perimetry
* Device: Confocal Scanning Laser Tomography
* Device: Optical Coherence Tomography (OCT)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: primary open angle glaucoma (POAG) spherical ametropia max. ± 8 dpt cylindrical ametropia max. ± 3 dpt distant visual acuity > 10/20 pupil diameter > 3 mm Exclusion Criteria: diabetic retinopathy asthma history of epilepsy or significant psychiatric disease medications known to effect visual field sensitivity infections (e.g., keratitis, conjunctivitis, uveitis) severe dry eyes miotic drug squint nystagmus albinism any ocular pathology, in either eye, that may interfere with the ability to obtain visual fields keratoconus intraocular surgery (except for uncomplicated cataract surgery) performed < 3 month prior to screening history or signs of any visual pathway affection other than glaucoma history or presence of macular disease and/or macular edema, ocular trauma, medications known to affect visual field sensitivity

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| perimetry, HRT, OCT<br>perimetry, HRT, OCT | Device: Perimetry<br>* different perimetric devices, different perimetric grids: Octopus: New Scotoma-Oriented Perimetry (SCOPE) Using a New Fast German Adaptive Threshold Estimation (GATE) HFA: 30-2, Sita (Swedish Interactive Thresholding Algorithm) full threshold<br>* Other names: Humphrey Field Analyzer 745i (HFA), Interzeag Octopus 101;Device: Confocal Scanning Laser Tomography<br>* HRT examinations for the clinical evaluation of the optic disc.<br>* Other names: Heidelberg Retina Tomograph (HRT);Device: Optical Coherence Tomography (OCT)<br>* imaging of the retinal nerve fiber layer<br>* Other names: Spectralis-OCT (Heidelberg Engineering, Heidelberg, Germany);|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of rate of progression | Perimetric measures every 3 month over 3 years | 36 month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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visual field, perimetry, progression, POAG, glaucoma