The Effect of Computerized Cognitive Training on Mood and Thinking Style Amongst Patients in Inpatient Settings

Study Overview
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Brief Summary
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The purpose of this randomized controlled trial is to establish feasibility and provide initial estimates of efficacy of two computerized cognitive training procedures (a form of Positive Mental Imagery Training, PMIT, and a form of Cognitive Control Training, CCT) delivered as adjuncts to treatment as usual (TAU) in inpatient mental health treatment settings.

Official Title
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The Effect of Computerized Cognitive Training on Mood and Thinking Style Amongst Patients in Inpatient Settings

Conditions
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Depression, Anxiety, Anhedonia

Intervention / Treatment
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* Behavioral: Positive Mental Imagery Training (PMIT)
* Behavioral: Cognitive Control Training (CCT)
* Other: Treatment as Usual


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Aged 18 years or above Sufficient German language skills Receiving treatment in a participating inpatient clinic during the timeframe of the study (i.e. they must be able to complete the training entirely within their admission). Exclusion Criteria: Existence of a condition or circumstances that would interfere with completion of the study procedures (e.g. severe visual impairment, neurological problem, acute psychosis or substance withdrawal symptoms)

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Positive Mental Imagery Training (PMIT)<br>Computerized Positive Mental Imagery Training (PMIT), a form of mental imagery-based cognitive bias modification adapted from previous experimental (e.g. Holmes, Lang, & Shah, 2009) and clinical (e.g. Blackwell & Holmes, 2010) work. The intervention consists of 8 sessions completed over a period of 2 weeks. The training takes place alongside participants' treatment as usual (TAU) in the inpatient setting. | Behavioral: Positive Mental Imagery Training (PMIT)<br> <br> Other: Treatment as Usual<br> <br> |
| Active Comparator: Cognitive Control Training (CCT)<br>An adaptive Paced Auditory Serial Addition Task (PASAT), adapted from that applied in previous studies (e.g. Siegle et al., 2007; Hoorelbeke et al., 2015). The intervention consists of 8 sessions completed over a period of 2 weeks. The training takes place alongside participants' treatment as usual (TAU) in the inpatient setting. | Behavioral: Cognitive Control Training (CCT)<br> <br> Other: Treatment as Usual<br> <br> |
| Active Comparator: Treatment as Usual<br>Participants will receive their treatment as usual (TAU) within the inpatient setting, which may include group/individual psychological therapy, a range of therapeutic activities, and pharmacological treatment. | Other: Treatment as Usual<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 21-item positive subscale from the extended Positive and Negative Affect Schedules | The Joviality, Self-Assurance, Attentiveness, and Serenity subscales of the extended PANAS (PANAS-X; Watson & Clark, 1994) will be administered, following previous experimental research examining the effect of positive mental imagery on state mood (e.g. Holmes, Lang, & Shah, 2009). Participants will be asked to rate the items according to how they have been feeling 'in the past week, that is, during the past seven days, including today'. | Post-intervention (2 weeks post-baseline) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 21-item positive subscale from the extended Positive and Negative Affect Schedules | The Joviality, Self-Assurance, Attentiveness, and Serenity subscales of the extended PANAS (PANAS-X; Watson & Clark, 1994) will be administered, following previous experimental research examining the effect of positive mental imagery on state mood (e.g. Holmes, Lang, & Shah, 2009). Participants will be asked to rate the items according to how they have been feeling 'in the past week, that is, during the past seven days, including today'. | Baseline, Follow-up (2 weeks after the post-intervention assessment) | 
| Dimensional Anhedonia Rating Scale | An extended 26-item version of the Dimensional Anhedonia Rating Scale (DARS; Rizvi et al., 2015) will be administered. | Baseline, Post-intervention (2 weeks post-baseline), Follow-up (2 weeks after the post-intervention assessment) | 
| Quick Inventory of Depressive Symptomatology - Self Report |  | Baseline, Post-intervention (2 weeks post-baseline), Follow-up (2 weeks after the post-intervention assessment) | 
| GAD-7 |  | Baseline, Post-intervention (2 weeks post-baseline), Follow-up (2 weeks after the post-intervention assessment) | 
| Positive Mental Health Scale |  | Baseline, Post-intervention (2 weeks post-baseline), Follow-up (2 weeks after the post-intervention assessment) | 
| Prospective Imagery Test |  | Baseline, Post-intervention (2 weeks post-baseline) | 
| Scrambled Sentences Test (SST) |  | Baseline, Post-intervention (2 weeks post-baseline) | 
| Implicit Associations Test (IAT) |  | Baseline, Post-intervention (2 weeks post-baseline) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Positive Affect, Mental Imagery, Cognitive Bias Modification, Cognitive Control Training