Pre-Emptive Analgesia Efficacy of Etoricoxib for Postoperative Pain

Study Overview
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Brief Summary
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Taken together, studies of the value of pre-emptive analgesia are inconclusive. This randomized, double-blind, dose-ranging, placebo-controlled study was therefore designed to test that a reduction in post-operative morphine consumption can be achieved by a single-dose of etoricoxib before induction of anesthesia.

Detailed Description
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Patients undergoing transabdominal hysterectomy were randomized to a group taking a single dose (orally) of etoricoxib 120 mg (n = 18), etoricoxib 180 mg (n = 17) or placebo (n = 15) 2 hours before surgery under the same standardized general anesthesia. At the post-anesthetic care unit, intravenous morphine titration was given before starting self-controlled analgesia (PCA) device. Morphine consumption, pain relief score, sedative score, global evaluation score, and side-effects were recorded at 1, 2, 4, 8 and 24 h post-operatively. The primary end points were morphine consumption within 24-hr post-operatively and total pain relief over 8 h (TOPAR8). Patient global satisfaction was also assessed.

Official Title
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A Randomized, Double-Blind, Controlled Trial of Etoricoxib as a Pre-Emptive Analgesic for Abdominal Hysterectomy

Conditions
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a Single-Dose of Etoricoxib, Post-Operative Morphine Consumption, Total Pain Relief Over 8 Hr(TOPAR8), Post Transabdominal Hysterectomy

Intervention / Treatment
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* Drug: a single-dose of Etoricoxib before induction of anesthesia


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: The ASA I or II patients undergoing elective transabdominal hysterectomy with general anesthesia Exclusion Criteria: Patients with history of opioid addiction or chronic pain Allergy to other nonsteroidal anti-inflammatory, or asthma Concomitant use of tricyclic antidepressants, opioid analgesics, antihistamines, tranquilizers, hypnotics, sedatives, or systemic corticosteroids Those unable to understand the principle of patient-controlled analgesia(PCA) device were excluded from the study

Ages Eligible for Study
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Minimum Age: 15 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: a single-dose of Etoricoxib before induction of anesthesia|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The primary end points were morphine consumption within 24-hr post-operatively |  |  | 
| and total pain relief over 8 h (TOPAR8). |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patient global response to therapy |  |  | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Abdominal hysterectomy,, Etoricoxib,, morphine consumption,, pre-emptive analgesia