Transcranial Magnetic Stimulation for Borderline Personality Disorder

Study Overview
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Brief Summary
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Primary purpose : to assess the effect on neuropsychological tasks related to planning of 10 daily sessions of right dorsolateral prefrontal cortex with High-frequency repetitive transcranial magnetic stimulation (rTMS) on borderline personality disorder (BPD) patients. Hypothesis : BPD patients receiving 10 sessions of rTMS will have greater improvement in the average number of move to achieve tasks of the Tower of London, than those receiving sham rTMS.

Official Title
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Effect of Repetitive Transcranial Magnetic Stimulation (rTMS) on Borderline Personality Disorder (BPD)

Conditions
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Borderline Personality Disorder

Intervention / Treatment
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* Procedure: repetitive Transcranial Stimulation Magnetic (rTMS)
* Procedure: sham rTMS


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 20 to 45 years old Borderline Personality Disorder (Diagnostic Interview for Borderline Personality Disorder > 8) psychiatric follow-up righthander informed consent affiliated to medical insurance Exclusion Criteria: bipolar disorder substance use disorder Major Depressive Disorder or Stress Post Traumatic Disorder history of epilepsy neurosurgery cardiac pacemaker lefthander involuntary admission participation in an other research legal guardianship poor mastery of french.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: rTMS<br>rTMS sessions | Procedure: repetitive Transcranial Stimulation Magnetic (rTMS)<br>* The motor threshold was determined in each subject once, before treatment. This was defined as the lowest stimulation intensity capable of inducing a visible movement at least five times out of 10 stimulations. The position of the right dorsolateral prefrontal cortex was defined as 5 cm anterior (in a parasagittal line) to the motor cortex. The stimulus intensity was 80% of the patient's motor threshold intensity. Treatments were given for 20 minutes per day over 10 working days.<br>|
| Sham Comparator: control<br>sham rTMS (control) | Procedure: sham rTMS<br>* sham rTMS<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Tower of London |  | Inclusion, 15th day, 30th day and 3rd month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Balloon Analog Risk Task |  | Inclusion, 15th day, 30th day and 3rd month | 
| Micro-World Test |  | Inclusion, 15th day and 3rd month | 
| Borderline Personality Disorder Severity Index |  | Pre-inclusion, 30th day and 3rd month | 
| Symptom Check List - 90 |  | Inclusion, 15th day, 30th day and 3rd month | 
| Barratt Impulsivity Scale |  | Inclusion and 3rd month | 
| Global Assessment Scale |  | Inclusion and 3rd month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Borderline Personality Disorder, Transcranial Magnetic Stimulation, Neuropsychological Test, Randomised Control Trial