Pilot Study Of Primary And Secondary Attention-Deficit/Hyperactivity Disorder Among Survivors Of Childhood Cancer

Study Overview
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Brief Summary
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This is a pilot study that will be an exploratory investigation of the rate of occurrence of ADHD/S-ADHD in adolescent cancer survivors. The procedures that will be used for identifying attention problem symptoms, determining the frequency and severity of such symptoms, and characterizing the level of impairment resulting from the symptoms are novel to pediatric oncology research.This pilot study will draw from the approach used in traumatic brain injury research of post-injury effects to illuminate more clearly the nature of attentional late effects experienced by survivors of childhood cancer.

Detailed Description
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This study will investigate the feasibility of assessing symptoms of developmental ADHD and secondary ADHD (S-ADHD) among adolescent survivors of childhood cancer using a structured diagnostic clinical interview procedure. (S-ADHD describes an acquired clinical presentation that is consistent with the diagnostic criteria of ADHD). This study will provide preliminary estimates of the rate of occurrence of ADHD/S-ADHD among adolescent survivors of childhood cancer as compared to the prevalence of developmental ADHD in the general population. The study will examine the relationship between ADHD/S-ADHD symptoms and laboratory measures traditionally used to assess specific components of attention (e.g., CPT) in survivors of childhood cancer. The study will examine the relationship between ADHD/S-ADHD symptoms and smoking (including intentions, behaviors, and motivators) among adolescent survivors of childhood cancer.

Official Title
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Pilot Study Of Primary And Secondary Attention-Deficit/Hyperactivity Disorder Among Survivors Of Childhood Cancer

Conditions
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ADHD, Cancer

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients treated for acute lymphoblastic leukemia (ALL) OR primary central nervous system (CNS) tumor. Completed primary treatment at least one year prior to enrollment with no evidence of active disease. Age 12-17 years inclusive at the time of enrollment. At least one parent/guardian must be present. Participant and parent are able to understand English. Participant and parent are willing and able to provide consent/assent according to institutional guidelines. Parent/guardian signs consent. Exclusion Criteria: 1.Significant impairment in intellectual functioning (e.g., full or estimated IQ <70) as documented in the medical record.

Ages Eligible for Study
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Minimum Age: 12 Years
Maximum Age: 17 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Study Participants<br>St. Jude Children's Research Hospital patients from Leukemia, Neuro-Oncology, Radiation Oncology, and After Completion of Therapy (ACT) clinics. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| This study will investigate the feasibility of assessing symptoms of developmental ADHD and secondary ADHD (S-ADHD) among adolescent survivors of childhood cancer using a structured diagnostic clinical interview procedure. |  | 1 year | 
| This study will provide preliminary estimates of the rate of occurrence of ADHD/S-ADHD among adolescent survivors of childhood cancer as compared to the prevalence of developmental ADHD in the general population. |  | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| This study will examine the relationship between ADHD/S-ADHD symptoms and laboratory measures traditionally used to assess specific components of attention (e.g., CPT) in survivors of childhood cancer. |  | 1 year | 
| This study will examine the relationship between ADHD/S-ADHD symptoms and smoking (including intentions, behaviors, and motivators) among adolescent survivors of childhood cancer. |  | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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ADHD, childhood cancer, ADHD/Secondary ADHD Among Survivors of Childhood Cancer