Fatigability and Physical Performance: Effects of Resistance Training Variables Manipulation

Study Overview
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Brief Summary
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This study evaluate whether resistance training variables modulate the fatigability (power-duration relationship) and physical performance in adults and older adults

Detailed Description
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The resistance training variables manipulation is utilized for maximize the results of resistance training. However it is unclear whether the resistance training variables manipulation modulates the fatigability (i.e. power-duration relationship) and whether this explains the improvement on physical performance (i.e. gait speed, sit-to-stand and timed up and go tests).

Official Title
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Fatigability and Physical Performance: Effects of Resistance Training Variables Manipulation

Conditions
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Aging

Intervention / Treatment
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* Other: Resistance training, LL
* Other: Resistance training, HL
* Other: Resistance training, HVHL
* Other: Control group, CG


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Postmenopausal women (>12 months amenorrhea) with age above or equal 50 years old. No hormone therapy or phytoestrogens Exclusion Criteria: No-drinker alcohol (no alcohol intake whatsoever in their diet); Non- smokers; Hypertensive with uncontrolled blood pressure values; Diabetic with uncontrolled glycemia; Presence of arthropathies; Presence of myopathies; Skeletal musculotendinous disorder.

Ages Eligible for Study
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Minimum Age: 50 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Lower load resistance training (LL)<br>In the LL group, postmenopausal women will perform the resistance training with moderate volume (i.e. three sets per exercise performed until or close to failure) and low load (i.e. 30% of 1RM) | Other: Resistance training, LL<br>* In LL, the postmenopausal women will be submitted to 12 weeks of Resistance training with moderate volume (i.e. three sets per exercise) and low load (i.e. 30% of one repetition maximum)<br>|
| Experimental: Higher load resistance training (HL)<br>In the HL group, postmenopausal women will perform the resistance training with moderate volume (i.e. three sets per exercise performed until or close to failure) and high load (i.e. 80% of 1RM) | Other: Resistance training, HL<br>* In HL, the postmenopausal women will be submitted to 12 weeks of Resistance training with moderate volume (i.e. three sets per exercise) and high load (i.e. 80% of one repetition maximum)<br>|
| Experimental: Higher volume resistance training (HVHL)<br>In the HVHL group, postmenopausal women will perform the resistance training with high volume (i.e. six sets per exercise performed until or close to failure) and high load (i.e. 80% of 1RM) | Other: Resistance training, HVHL<br>* In HVHL, the postmenopausal women will be submitted to 12 weeks of Resistance training with high volume (i.e. six sets per exercise) and hig load (i.e. 80% of one maximum repetition)<br>|
| Other: Control group, (CG)<br>In CG, the postmenopausal women group will not perform exercise | Other: Control group, CG<br>* The CG groups do not will performed the exercise.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fatigability | The fatigability will be evaluate by 60 maximum voluntary isometric contractions (3 s contraction, 2 s rest) in knee extensors at 70 degree. | Changes in fatigability measure (e.g. baseline and after 12 weeks of intervention) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Physical Performance | The physical performance will be evaluate by gait speed tests (e.g. 10m walking at usual and fast pace, 400m walk at usual and fast pace). | Changes in physical performance measure (e.g. baseline and after 12 weeks of intervention) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Fatigability, Postmenopausal Woman, Resistance training, Physical performance, Older adults