Prospective Investigation of Multiple Sclerosis in the Three Rivers Region

Study Overview
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Brief Summary
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In this longitudinal prospective natural history study of multiple sclerosis (MS), the overarching goal is to understand the factors that influence individual variation in disease trajectory and treatment response and pave the way for realizing precision medicine in MS. Because MS is a chronic neurological disorder, this observational cohort study will span a 30-year time frame.

Detailed Description
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Research Activities: Initial Questionnaire, Questionnaire for Self-Reported Outcomes, Biological Sample Collection (Blood, Stool, Urine, Cerebrospinal fluid), Genetic Analysis, Standard Quantitative Assessment of Function, Cognitive Assessment, Neuroimaging, Biometric Sensors, Social Network Questionnaire, Connor-Davidson Resilience Scale, NEO Five-Factor Inventory, and the COVID19 Response Surveys.

Official Title
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Prospective Investigation of Multiple Sclerosis in the Three Rivers Region

Conditions
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Multiple Sclerosis

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Inclusion criteria for MS patients include: willing and able to give consent age 7 years or older diagnosis of multiple sclerosis or related disorders, including a first central nervous system demyelinating episode with a positive MRI scan or abnormal MRI scans characteristic of MS but no clinical symptoms of the disease For healthy controls: Age 7 years or older Willing and able to provide consent (for >=18 years) or assent with permission from at least one of the child's parents (for <18 years) No known personal history of multiple sclerosis or related disorders No other chronic diseases Family members, unrelated household controls, or controls from the general population could be eligible There is no exclusion criteria.

Ages Eligible for Study
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Minimum Age: 7 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| People with Multiple Sclerosis or Related Disorders<br>Individuals must be 7 years or older, diagnosed with multiple sclerosis or related disorders, including a first central nervous system demyelinating episode with a positive MRI scan or abnormal MRI scans characteristic of MS but no clinical symptoms of the disease | |
| People without Multiple Sclerosis or Related Disorders<br>Control participants must be 7 years or older, have no known personal history of multiple sclerosis or related disorders, no other chronic disease, and can be a family member, unrelated household control, or control from the general population. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Establish a prospective cohort of well-characterized MS patients and controls | For this longitudinal prospective observational study, we will establish a prospective cohort of well-characterized MS patients and controls (2:1). | within 30 years | 
| Investigate the predictors of the variations in disease trajectory and treatment response | Understanding the factors that influence disease trajectory and treatment response will pave the way to realize precision medicine in delivering individualized MS care. | within 30 years |