Sonography and Haemophilia

Study Overview
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Brief Summary
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The aim of this study is to evaluate the possibility of establishing a patient-based ultrasound monitoring of the knee (representing a target joint accessible with any hand) with a handheld device: The following questions will be answered: What is necessary for the organisational implementation of a patient-based ultrasound monitoring in patients with haemophilia? Is it possible to train patients with haemophilia to perform sonography of their target joints? Does a patient-based ultrasound monitoring with a handheld device work in a home setting? What is the quality of the patient's self-acquired ultrasound images? Will the test persons be able to distinguish normal findings from (any) pathologic findings?

Official Title
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Self-conducted Sonographic Monitoring of the Target Joints in Patients With Severe Haemophilia

Conditions
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Sonography, Haemophilia

Intervention / Treatment
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* Other: feasibility study


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adult patients (≥ 18 years of age) suffering from severe haemophilia A or B No professional medical background Submitted written consent to participate in the study and to use their study related pseudonymized data Exclusion Criteria: Patients suffering from other bleeding diseases Participants < 18 years of age Participants without written consent Professional medical background

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Adult patients with severe haemophilia A or B<br>Adult patients (≥ 18 years of age) suffering from severe haemophilia A or B No professional medical background Submitted written consent to participate in the study and to use their study related pseudonymised data | Other: feasibility study<br>* The aim of this study is to evaluate the possibility of establishing a patient-based ultrasound monitoring of the knee (representing a target joint accessible with any hand) with a handheld device.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Landmarks of the Hemophilia Early Arthropathy Detection with Ultrasound (HEAD-US) protocol - Anterior mid-sagittal ultrasound image | The patients will perform an ultrasound of their left and right knee according to the HEAD-US protocol. The following ultrasonic image is needed: Anterior mid-sagittal ultrasound image. Patella, distal femur, suprapatellar recess, suprapatellar fat pad and prefemoral fat pad must be visible. | 5 min | 
| Landmarks of the Hemophilia Early Arthropathy Detection with Ultrasound (HEAD-US) protocol - Anterolateral transverse ultrasound image | The patients will perform an ultrasound of their left and right knee according to the HEAD-US protocol. The following ultrasonic image is needed: Anterolateral transverse ultrasound image. Patellofemoral joint, lateral parapatellar recess, lateral patellar retinaculum and lateral femoral condyle must be visible. | 5 min | 
| Landmarks of the Hemophilia Early Arthropathy Detection with Ultrasound (HEAD-US) protocol - Transverse ultrasound image - Transverse ultrasound image | The patients will perform an ultrasound of their left and right knee according to the HEAD-US protocol. The following ultrasonic image is needed: Transverse ultrasound image. Medial facets of the trochlea, lateral facets of the trochlea and cartilage must be visible. | 5min | 
| Landmarks of the Hemophilia Early Arthropathy Detection with Ultrasound (HEAD-US) protocol - Coronal ultrasound image | The patients will perform an ultrasound of their left and right knee according to the HEAD-US protocol. The following ultrasonic image is needed: Coronal ultrasound image. Medial meniscus, boundaries of the femur, boundaries of the tibia must be visible. | 5 min |