Comparison of Emergence and Oxygenation During One-lung Ventilation With Desflurane and Propofol Anesthesia

Study Overview
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Brief Summary
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Which is more adequate general anesthetic agent, desflurane or propofol, for emergence and recovery time, and perioperative oxygenation in lung resection surgery?

Detailed Description
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The investigators plan to investigate the effects of desflurane on oxygenation (prevention of HPV) of OLV compare with propofol which is used in general anesthesia for lung resection. Transesophageal echocardiography (TEE) wiill be used to measure pulmonary blood flow during surgery visible and successively. To confirm the effect of HPV by measuring the change in pulmonary blood flow. The correlation between the blood oxygen concentration and attenuation of blood flow will be investigated.

Official Title
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Comparison of Emergence and Recovery Time, and Evaluation of Oxygenation During One-lung Ventilation With Desflurane and Propofol Anesthesia in Lung Surgery- A Pilot Study

Conditions
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Lung Cancer

Intervention / Treatment
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* Drug: desflurane
* Drug: propofol


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients agree to participate in the study Patients undergoing lung cancer surgery requiring one-lung ventilation. American Society of Anesthesiologists Physical Status Class 1 or 2 Exclusion Criteria: Patients with any of the following will be excluded from lung cancer patients. New York Heart Association Classification more than 2 Respiratory dysfunction Vital Capacity or percent predicted Forced expiratory volume in one second is less than 50 % Pulmonary hypertension with mean pulmonary arterial pressure more than 30 mmHg Coagulation dysfunction The administration of steroids and immunosuppressive agents within 3 months prior to surgery Infection with active inflammation Pneumonectomy patients Cases of epidural anesthesia is contraindicated

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Desflurane<br>Desflurane group: this group of patients receives desflurane as the main anesthetic agent in addition to remifentanil infusion at 0.1 0.3 mcg/kg/min during one-lung anesthesia. Bispectral index will be maintained between 45 and 50. Arterial blood gases and pulmonary blood flow by using tansesphageal echocardiogrphy will be measured. | Drug: desflurane<br>* Desflurane group: this group of patients receives desflurane as the main anesthetic agent during one-lung anesthesia. Propofol group: this group of patients receives propofol as the main anesthetic agnet during on-lung anesthesia.<br>* Other names: Suprene;|
| Active Comparator: Propofol<br>Propofol group: this group of patients receives propofol as the main anesthetic agent in addition to remifentanil infusion at the rate of 0.1 0.3 mcg./g/min during one-lung anesthesia. Bispectral index will be maintained between 45 and 50. Arterial blood gases and pulmonary blood flow by using tansesphageal echocardiogrphy will be measured. | Drug: propofol<br>* Propofol group:this group of patients receives propofol as the main anesthetic agent during one-lung anesthesia.<br>* Other names: Diprivan;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| oxygenation | Arterial blood gases are monitored.Pulmonary blood flow is measured using transesophageal echocardiogram. | prior to surgery to one-hour after extubation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| rapidity of emergence from anesthesia | time to extubation | one minute after cessation of anethetic agents to one hour after extubation | 
| quality of consiousness | quality of consciousness will be assessed using Aldrete score | after extubation | 
| postoperative nausea and vomiting | degree of nausea and frequency of vomiting | on the postoperative day 1 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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one-lung ventilation, oxygenation