Evaluation of EEG With Respect to the Change of Depth of Anesthesia During General Anesthesia

Study Overview
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Brief Summary
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The BIS Index, one of the VISTA Monitor output parameters, may be used as an aid in monitoring the effects of certain anesthetic agents;and its usage with certain anesthetic agents may be associated with a reduction in primary anesthetic use and a reduction in emergence and recovery time. However, this equipment does not give the proper anesthetic depth index is a number of experimental results have been reported. Therefore, the investigators study that the BIS VISTA receives an electroencephalogram (EEG) obtained through the depth of anesthesia monitors brain waves to collect statistical data, through mathematical analysis to analyze the exact correlation between the patient's brain waves and the depth of anesthesia.

Detailed Description
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General anesthesia is accompanied during surgery gives a lot of satisfaction and impact on surgical outcomes of patients depending on the dose of the anesthetic, as well as operation time and intensity. The BIS Index, one of the VISTA Monitor output parameters, may be used as an aid in monitoring the effects of certain anesthetic agents;and its usage with certain anesthetic agents may be associated with a reduction in primary anesthetic use and a reduction in emergence and recovery time. However, this equipment does not give the proper anesthetic depth index is a number of experimental results have been reported. Therefore, the investigators study that the BIS VISTA receives an electroencephalogram (EEG) obtained through the depth of anesthesia monitors brain waves to collect statistical data, through mathematical analysis to analyze the exact correlation between the patient's brain waves and the depth of anesthesia.

Official Title
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Evaluation of EEG With Respect to the Change of Depth of Anesthesia

Conditions
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Anesthesia

Intervention / Treatment
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* Device: Electroencephalography
* Drug: Propofol
* Drug: Rocuronium bromide


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: American Society of Anesthesiologist[ASA] class 1-2 written informed consent Exclusion Criteria: allergy of neuromuscular blocking drugs or other medications used during general anesthesia known or suspected upper respiratory infection suspected difficult tracheal intubation Uncontrolled Hypertension known or suspected psychologic disorder known or suspected significant renal dysfunction known or suspected severe hepatic dysfunction known or suspected significant cardiovascular dysfunction

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Electroencephalography<br>Standard monitoring included electrocardiogram, noninvasive arterial blood pressure, pulse oximetry, and BIS-VISTATM sensor at OR. Raw EEG in a steady state was collected for 5 minutes. Anesthesia was induced with intravenous 1% propofol (1.5-2.5 mg/kg) and rocuronium bromide (0.6 mg/kg) Mechanical ventilation was initiated Anesthesia was maintained with desflurane at an end-tidal concentration of 6-7 %, with a fraction of inspired oxygen of 0.5 (fresh gas flow; O2 1.5 L/min and air 2.5 L/min). On completion of the surgery, all anesthetic gases were discontinued and the FiO2 was increased to 1.0. After extubation, BIS-VISTA TM monitoring was stopped. | Device: Electroencephalography<br>* Raw EEG signals were acquired at a sampling rate of 128Hz using a BIS-VISTATM monitor and was measured during all anesthetic period.<br>Drug: Propofol<br>* intravenous 1% propofol (1.5-2.5 mg/kg)<br>* Other names: Fresofol MCT 1%;Drug: Rocuronium bromide<br>* intravenous rocuronium bromide (0.6 mg/kg)<br>* Other names: Esmerone;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| EEG acquisition | Raw EEG signals were acquired at a sampling rate of 128Hz using a BIS-VISTATM monitor and was measured during intraoperative period. Transferring the raw EEG signal obtained from BIS VISTA monitor to a computer, the data is processed using MATLAB | From 5minutes before induction to extubation | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Bispectral index (BIS), EEG, Depth of anesthesia