linjc16/ctgov huggingface dataset:
Postoperative Analgesic Efficacy of Pericapsular Nerve Group Block (PENG) Block for Knee Arthroscopy

Study Overview
=================
Brief Summary
-----------------
Pericapsular nerve group block (PENG) has been deemed as a safe and effective regional technique for postoperative pain after knee arthroscopy.

Detailed Description
-----------------
Pericapsular nerve group block(PENG) has been deemed as a safe and effective regional technique for postoperative pain after knee artroscopy. Blockade of the branches of the femoral and obturator nerves that provide innervation to any structures distal enough to be useful in knee.

Official Title
-----------------
Postoperative Analgesic Efficacy of Pericapsular Nerve Group Block (PENG) Block for Knee Arthroscopy

Conditions
-----------------
Postoperative Pain

Intervention / Treatment
-----------------
* Procedure: PENG Block combinated with PCA
* Procedure: PCA


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients agreed to receive PENG block Knee arthroscopy Exclusion Criteria: Other kinds of knee surgery Patients refuse to receive PENG block

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: PENG Block<br>PENG Block combinate with PCA | Procedure: PENG Block combinated with PCA<br>* After spinal anesthesia PENG block will be performed<br>* Other names: PCA;|
| Sham Comparator: CONTROL<br>PCA | Procedure: PCA<br>* PCA will be applied after surgery<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| First analgesic demand | The time interval from PENG blocks to the first analgesic demand. | 24 Hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Opioid consumption | Total opioid analgesic consumption | 24 Hours | 
| Numeric Rating Scale | The maximum score on a 10cm numeric rating scale: (0 to 10cm) (0 = no pain, 10 = worst imaginable pain) | 24 Hours |
One Year Clinical Evaluation of Translucent Zirconia Crowns in Dental Esthetic Zone With Biologically Oriented Preparation Technique (BOPT) Versus Conventional Preparation (Randomized Clinical Trial)

Study Overview
=================
Brief Summary
-----------------
Aim of the studyto evaluate the clinical behavior of translucent zirconia crown in dental esthetic zone with biologically oriented preparation technique versus conventional preparation.

Official Title
-----------------
One Year Clinical Evaluation of Translucent Zirconia Crowns in Dental Esthetic Zone With Biologically Oriented Preparation Technique (BOPT) Versus Conventional Preparation (Randomized Clinical Trial)

Conditions
-----------------
Single Crowns in Aesthetic Dental Zone

Intervention / Treatment
-----------------
* Other: conventional preparation design
* Other: biologically oriented preparation technique


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All subjects are required to be: From 21-35 years old, be able to read and sign the informed consent document. Have no active periodontal or pulpal diseases, have teeth with good restorations Psychologically and physically able to withstand conventional dental procedures Patients with teeth problems indicated for single all ceramic restoration in maxillary esthetic zone cr Badly decayed teeth Teeth restored with large filling restorations Endodontically treated teeth Malformed teeth Malposed teeth (Tilted, over-erupted, rotated, etc.) Spacing between maxillary teeth in esthetic zone Able to return for follow-up examinations and evaluation Exclusion Criteria: Patient less than 21or more than 35 years Patient with active resistant periodontal diseases Patients with poor oral hygiene and uncooperative patients Pregnant women Patients in the growth stage with partially erupted teeth Psychiatric problems or unrealistic expectations Patient with periodontal problems patients with malocclusion or parafunctional habits

Ages Eligible for Study
-----------------
Minimum Age: 21 Years
Maximum Age: 35 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: single crown in dental aesthetic zone<br>teeth in dental aesthetic zone | Other: conventional preparation design<br>* chamfer finish line<br>* Other names: horizontal preparation technique;|
| Experimental: teeth need single crown in dental aesthetic zone<br>teeth in dental aesthetic zone | Other: biologically oriented preparation technique<br>* shoulder less preparation design<br>* Other names: vertical perpetration technique;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Marginal adaptation | Measured using Modified USPHS criteria1 | 1 year |
Intracranial Neurophysiological Signatures of Fear and Anxiety in Humans

Study Overview
=================
Brief Summary
-----------------
Anxiety disorders such as post-traumatic stress disorder (PTSD) and generalized anxiety disorder (GAD) affect a large number of individuals with a significant portion of patients failing to improve with current treatments. The purpose of this study is to understand the brain mechanisms that produce fear and anxiety in humans. To accomplish this goal, we will measure the brain activity along with the heart rate and skin perspiration of patients while they are completing tasks on a computer. Some of the tasks will also use a virtual reality headset and transport the patient in a video game-like environment. These tasks will expose the participants to various levels of fear-provoking images.

Official Title
-----------------
Intracranial Neurophysiological Signatures of Fear and Anxiety in Humans

Conditions
-----------------
Fear, GAD, Emotional Memory, PTSD

Intervention / Treatment
-----------------
* Device: Deep Brain Stimulation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 18 years of age or older Has undergone acute depth or chronic responsive neurostimulation (RNS) electrode placement Willing to provide informed consent and participate in the study Ability to read and write English fluently Exclusion Criteria: Unwilling to provide informed consent Not a native English Speaker Has not undergone acute depth or chronic responsive neurostimulation (RNS) electrode placement

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: Deep Brain Stimulation|Deep brain stimulation will be used|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Physiological change - eye-blinks | Eye blinks will be measured using an eye tracking device and will be measure in blinks per second. | during the intervention/behavioral tasks with and without stimulation | 
| Physiological change - heart rate variability | heart rate variability will be measured in milliseconds. | during the intervention/behavioral tasks with and without stimulation | 
| Physiological change - skin conductance | Skin conductance will be measured in microSiemens. | during the intervention/behavioral tasks with and without stimulation | 
| Neurophysiological activity | Neurophysiological activity will be measured in Hz | during the intervention/behavioral tasks with and without stimulation |
Ocular Microvascular Changes in Patients With Sepsis

Study Overview
=================
Brief Summary
-----------------
This study evaluates differences in the ocular microcirculation between septic patients and healthy subjects and the course of ocular microvasculature in survivors and non-survivors over a 24 hours period of time in septic patients

Detailed Description
-----------------
Conjunctival imaging, using IDF video microscope, and retinal imaging, using portable digital fundus camera, as well as systemic hemodynamic measurements, were performed in septic patients at three time points: at baseline, 6 hours and 24 hours. Baseline conjunctival and retinal microcirculatory parameters were compared with healthy controls.

Official Title
-----------------
Ocular Microvascular Changes in Patients With Sepsis

Conditions
-----------------
Sepsis, Retinal Microcirculation Disorder, Conjunctiva; Disorder

Intervention / Treatment
-----------------
* Device: Incident dark field videomicroscope from Braedius
* Device: Fundus camera from Optomed


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: adult patients with sepsis or septic shock within the first 24 hours after ICU admission Exclusion Criteria: psychiatric disorders, brain diseases, chronic alcoholism, autoimmune rheumatic diseases ophthalmological diseases, such as glaucoma, age-related macular degeneration, diabetic retinopathy and cataract

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: Incident dark field videomicroscope from Braedius|It allows to look at conjunctival microcirculation|
|Device: Fundus camera from Optomed|It allows to monitor retinal microvasculature|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Microvascular flow index in conjunctival small vessels | Differences in MFI in conjunctival small vessels between septic patients and healthy controls and differences between survivors and non-survivors | 24 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Central retinal arteriolar equivalent of retinal vessels | Differences in central retinal arteriolar equivalent of retinal vessels between septic patients and healthy controls and differences between survivors and non-survivors | 24 hours | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Conjunctival microcirculation, retinal vessels, fundus imaging, IDF imaging, sepsis
Effects of Health Care Provider-mediated, Remote Coaching System Through the PDA-type Glucometer and the Internet on Diabetes Management

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to investigate the effectiveness of the new diabetes care delivery system applied to preexisting public health care resources through advanced information technologies such as PDA-type glucometer and the Internet on the glycemic control of type 2 diabetes patients lived in isolated rural area. The investigators conducted a prospective, randomized, controlled trial in patients with type 2 diabetes for 12 weeks. The intervention group was treated with the new health care delivery system, where diabetes center provided specialized management, mediated by nurse of primary health care posts using the Internet and the PDA-type glucometer, while the control group with conventional health care. HbA1c, fasting plasma glucose and lipids levels were measured at baseline and follow-up.

Conditions
-----------------
Type 2 Diabetes, Lifestyle Intervention, Glucose Control, Internet Communication

Intervention / Treatment
-----------------
* Behavioral: lifestyle counseling


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Type 2 diabetes patients Aged ≥ 40 years Baseline HbA1c of 7.0 to 11.0 % who had been already followed up for more than 6 months in the health care post Exclusion Criteria: Participants with diagnosed or suspected disease of the liver, pancreas, endocrine organs, or kidney Ischemic heart disease or cerebrovascular disease or a history of such disease A creatinine level > 0.133 mmol/L Treatment with an intensified insulin regimens and those unable .

Ages Eligible for Study
-----------------
Minimum Age: 40 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Lifestyle counseling<br> | Behavioral: lifestyle counseling<br>* supporting diabetes patients using Internet communication<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| HbA1c |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| PP2hr Lipid profile |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Diabetes, PDA, Internet, HbA1c
Home Safety Intervention Using a Safe Home Model

Study Overview
=================
Brief Summary
-----------------
This project seeks to determine the efficacy of safety education using a safe home model. The 4 X 8 ft. model is designed to look like a house; each of 4 rooms has a focused safety message. Families will be enrolled in the clinic and randomized to one of two groups, the safe home model group and the printed safety education materials (TIPP materials) group. The investigators will compare the retention of safety information among caregivers instructed using these two methods. The hypothesis is that families in the safe home model group will have improved retention of safety information.

Official Title
-----------------
A Randomized Trial of a Home Safety Intervention Using a Safe Home Model

Conditions
-----------------
Healthy

Intervention / Treatment
-----------------
* Behavioral: Injury prevention education (TIPP)
* Behavioral: Injury prevention education (safe home)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Caregivers of children younger than 6 years old Exclusion Criteria: Language other than English or Spanish
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Randomized
Intervention Model: Single Group Assignment


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: TIPP<br>Injury prevention education using TIPP materials | Behavioral: Injury prevention education (TIPP)<br>* using TIPP materials<br>|
| Experimental: Safe Home Model<br>Injury prevention education using safe home model | Behavioral: Injury prevention education (safe home)<br>* using safe home model<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
child, injury prevention
EndoSure Sensor for Long-term Follow-up After Endovascular AAA Repair

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to collect and compare EndoSure and EndoSure s2 Wireless AAA Pressure Sensor measurements with measurements from CT scan imaging, ultrasound, and other tests used to measure your AAA sac size and endoleaks following AAA repair, and during follow-up visits with your physician. An antenna is held over the patient's abdomen to measure pressure inside the aneurysm sac. The reading does not cause any discomfort, and dye or radiation is not needed to take the pressure measurement. To qualify, the patient must have a previously implanted EndoSure Sensor.

Official Title
-----------------
PRessure and Imaging-Using the CardioMEMS EndoSure Sensor for Long-term Follow-up After EVAR With Standard Surveillance (Prospective Registry)

Conditions
-----------------
Aortic Aneurysm, Abdominal

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Written informed consent obtained from subject or legal guardian Males or females, at least 18 years of age Subjects who are post-EndoSure Wireless AAA Pressure Sensor implantation, with pressure measurements at implant. Subjects willing to comply with the site-specific follow-up requirements of the investigator. Exclusion Criteria: Subjects whose clinical condition, in the Investigator's opinion, would not allow them to complete participation in the registry.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
EndoSure Sensor, s2 Sensor, abdominal aortic aneurysm
Transfusion and COVID-19

Study Overview
=================
Brief Summary
-----------------
Alsace was particularly and early on affected by SARS-CoV-2 and quickly implemented a reduction in scheduled admissions and non-urgent surgical interventions, making it possible to reduce requests for labile blood products linked to non-urgent surgical procedures. as has been reported in the literature; the population containment measures also led to a major reduction in traffic - and consequently accidents on the public roads. At the same time, other demands for blood products related to activities such as onco-hematology were little affected. Finally, the blood banks have adapted their collection procedure. To answer these questions, we propose to conduct a retrospective study over two parallel periods of 2019 and 2020 of the consumption of blood products on the one hand and the availability of stocks on the other hand.

Official Title
-----------------
Transfusion and COVID-19

Conditions
-----------------
COVID-19

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: Adults patient (≥18 years old) Patients admitted to Strasbourg University Hospitals for suspicion of Covid-19, between February 24 and May 31 of 2019 and 2020 Labile blood products consumed between February 24 and May 31 of 2019 and 2020 Subjects not having his opposition, after information, to the reuse of his data for the purposes of this research. Non-inclusion criteria: Patients who expressed opposition to participating in the study Patients under legal protection Patients under guardianship or curatorship

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Study of the consumption of labile blood products at Strasbourg University Hospitals, during the two covid-19 periods: from February 24 to May 31, 2019 and 2020 |  | Files analysed retrospectively from from February 24 to May 31, 2019 and from February 24 to May 31, 2020 will be examined] | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
COVID-19, Blood donation, Blood transfusion, Labile products, Blood platelets, Psoralen, ECMO, SARS-CoV-2, Consumption of blood products
Association of Haptoglobin 2-2 With Postoperative Delirium

Study Overview
=================
Brief Summary
-----------------
Patients with major orthopedic surgery will be recruited. Participants will be monitored for delirium after surgery. Participants' blood will be harvested for the determination of haptoglobin types, levels of oxidative stress and inflammation. Investigators will then analyze the data to see if haptoglobin 2-2 type is associated with an increased postoperative delirium, inflammation and oxidative stress.

Official Title
-----------------
Determination of the Association of Haptoglobin 2-2 With Delirium After Orthopedic Surgery

Conditions
-----------------
Postoperative Delirium

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: American Society of Anesthesiologists physical status I to III class for major orthopedic surgery (hip or knee replacement or spinal surgery) No psychological and psychiatric history and presentation before surgery No major organ dysfunction or failure Exclusion Criteria: Anemia (hemoglobin < 100 g/l) preoperatively. Requires > 4 units of allogeneic red blood cell transfusion during the surgery Using steroids or anti-psychological and anti-psychiatric drugs. A small dose of steroid for postoperative anti-nausea/vomiting is allowed and will not be considered as a indication for exclusion. Can not cooperate with the study History of bleeding BMI < 18 or > 30 History of hemoglobin metabolism disorder

Ages Eligible for Study
-----------------
Minimum Age: 45 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Adult non-haptoglobin 2-2 group<br>Patients are 45 to 65 years old. | |
| Adult haptoglobin 2-2 group<br>Patients are 45 to 65 years old. | |
| Elder non-haptoglobin 2-2 group<br>Patients are elder than 65 years. | |
| Elder haptoglobin 2-2 group<br>Patients are elder than 65 years. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative delirium incidence | The incidence of delirium as assessed by intensive care unit-confusion assessment method will be determined. | From day 0 to up to 7 days after the surgery | 
| Postoperative delirium duration | The duration of delirium as assessed by intensive care unit-confusion assessment method will be determined. | From day 0 to up to 7 days after the surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Oxidative stress level | The level of malondialdehyde in the blood will be measured by ELISA. | Day 0 to day 2 after the surgery | 
| Inflammation level | The levels of interleukin 1beta and interleukin 6 in the blood will be assessed by ELISA. | Day 0 to day 2 after the surgery |