Lung Ultrasound Assessment of Fluid Overload in Haemodialysis Patients

Study Overview
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Brief Summary
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Determination of the hemodialysis ultrafiltration volume is guided by the clinician's estimate of dry weight. A poor estimate of this dry weight may result in insufficient fluid depletion causing a state of volume overload, which may be associated with long-term left ventricular failure, high blood pressure and excess of mortality. The diagnosis of fluid overload in haemodialysis patient is routinely based on clinical examination which consists of cardiopulmonary auscultation and edema palpation of limb member. Clinical examination can be completed by paraclinical examinations, and bioimpedance is an objective tool that assess fluid overload state. This test provides an individualized hydration status and fluid overload based on normal extracellular volume considering body composition. Echocardiography allows an accurate assessment of blood volume status by simultaneous studying left ventricular filling pressures, systolic pulmonary artery pressure and the diameter of the inferior vena cava. Lung ultrasound analyses the B-lines defined as artefactual images resulting from contact between air in alveoli and water in septa. It can estimate pulmonary congestion. The aim of the study is to evaluate the lung ultrasound using 8 sites score accuracy for estimating fluid overload of patients before hemodialysis session.

Official Title
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Lung Ultrasound Assessment of Fluid Overload in Haemodialysis Patients Using 8 Sites Score

Conditions
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Lung Ultrasound, Hemodialysis Complication

Intervention / Treatment
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* Other: lung ultrasound


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age over 18 years old patients on hemodialysis for more than 3 months; patients without cardiological or infectious event for at least 3 months; patients having at least 2 dialysis session per week; patients affiliated with a health insurance plan; patients having signed an informed consent. Exclusion Criteria: Pulmonary fibrosis or active lung disease; residual diuresis over 500 mL per day; body mass index (BMI) < 21 and > 28 Kg/m²; medical history of major amputation (subgonal or transfemoral); pacemaker carrier; patients with orthopedic prosthesis.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: lung ultrasound|Subjects are enrolled during their usual session in the hemodialysis unit of the Amiens University Hospital. Before starting the hemodialysis, lung ultrasound according to the 8 sites score and a measure of bioimpedance will be performed in dorsal decubitus. In a 2nd time, an echocardiography is realized. During haemodialysis session, biological analysis and clinical score will be assessed|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| number of patients with fluid overload | Fluid overloaded are determined by both tecniques : estimated fluid overload and lung ultrasound measured fluid overload | one day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Lung ultrasound, Hemodialysis Complication, hemodialysis ultrafiltration volume