Biobehavioral Correlates of Cancer-related Cognitive Dysfunction and Its Co-occurring Symptoms

Study Overview
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Brief Summary
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This descriptive, cross-sectional study will evaulate and fully characterize factors associated with cognitive dysfunction in Breast Cancer (BCS) and Colorectal Cancer (CRC) survivors that have cognitive concerns, and factors associated with psychoneurological symptom cluster in BCS and CRC survivors.

Detailed Description
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Primary Aim: To identify demographic factors (age and education), medical and cancer treatment-related factors (comorbidities and treatment type), psychosocial factors (perceived stress, affect, optimism, coping, emotional support), cancer-related symptoms (pain, depression, anxiety, fatigue and sleep disturbance), and genetic factors (APOE, COMT, BDNF) associated with the level of subjective or the level of objective cognitive dysfunction in breast cancer and colorectal cancer survivors. Secondary Aim: To identify demographic factors (age and education), medical and cancer treatment-related factors (comorbidities and treatment type), psychosocial factors (perceived stress, affect, optimism, coping, emotional support), and genetic factors (APOE, COMT, BDNF) associated with psychoneurological symptom cluster using either subjective or objective cognitive dysfunction in breast cancer and colorectal cancer survivors.

Official Title
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Biobehavioral Correlates of Cancer-related Cognitive Dysfunction and Its Co-occurring Symptoms

Conditions
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Survivorship, Cognitive Dysfunction, Pain, Depression, Anxiety, Fatigue, Sleep Disturbance

Intervention / Treatment
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* Behavioral: Cognitive Dysfunction


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Inclusion Criteria for Breast cancer survivors: Female BCS ≥ 21 years of age and older Ability to provide written consent and HIPAA authorization ≥6 months post-adjuvant therapy and neo-adjuvant therapy for early stage (Stage I-IIIA) breast cancer. Current Aromatase Inhibitors or Tamoxifen treatment at time of enrollment is allowed. Identify cognitive concerns (select yes) Inclusion Criteria for Colorectal cancer survivors: Male or female CRC survivors Ability to provide written consent and HIPAA authorization ≥ 21 years of age and older ≥6 months post-adjuvant therapy and neo-adjuvant therapy for early stage (stage I-III) CRC Identify cognitive concerns (select yes) Exclusion Criteria: Report metastatic breast or colorectal cancer (Stage IV) at time of consenting. Unable to read and understand English to complete survey questionnaires.

Ages Eligible for Study
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Minimum Age: 21 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Breast Cancer and Colorectal Cancer Survivors<br>The purpose of this study is to explore the factors related with cognitive concerns and other symptoms in breast and colorectal cancer survivors. | Behavioral: Cognitive Dysfunction<br>* To fully characterize factors associated with cognitive dysfunction in BCS and CRC survivors that have cognitive concerns and (2) to fully characterize factors associated with psychoneurological symptom cluster in BCS and CRC survivors.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Subjective Cognitive Dysfunction | PROMIS - Cognitive Abilities and Concerns | greater than or equal to 6 months post cancer treatment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Objective Cognitive Dysfunction | Visual Episodic Memory | greater than or equal to 6 months post cancer treatment | 
| Objective Cognitive Dysfunction | Working Memory | greater than or equal to 6 months post cancer treatment | 
| Objective Cognitive Dysfunction | Executive Functioning | greater than or equal to 6 months post cancer treatment | 
| Objective Cognitive Dysfunction | Sustained Attention | greater than or equal to 6 months post cancer treatment | 
| Objective Cognitive Dysfunction | Visuospatial Working Memory | greater than or equal to 6 months post cancer treatment | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Breast Cancer and Colorectal Cancer, Co-Occurring Symptoms