Association of Processing Speed Dysfunction and Brain Functional Abnormality in ECTS

Study Overview
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Brief Summary
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Epilepsy with centrotemporal spikes (ECTS) is the most common epilepsy syndrome in children. Language impairment has been widely investigated in patients with ECTS, but little is known about the cognitive dysfunction of processing speed and its neuroimaging mechanism.

Detailed Description
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OBJECTIVE To investigate the processing speed dysfunction in patients with ECTS, and the associated brain functional abnormality using functional magnetic resonance imaging (fMRI) and 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET). DESIGN, SETTING, AND PARTICIPANTS This study prospectively enrolled ECTS patients (n = 28) from June 2019 and June 2021. Twenty age- and gender- matched healthy children and another twenty children with extracranial tumors were enrolled as controls. Patients with ECTS and healthy controls underwent neuropsychological testing and fMRI examination. In addition, ECTS patients and children with extracranial tumors underwent 18F-FDG PET examination.

Official Title
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Association of Processing Speed Dysfunction and Brain Functional Abnormality in Childhood Epilepsy With Centrotemporal Spikes

Conditions
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Epilepsy, Rolandic

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: (a) age between 6 and 18 years; (b) 18F-FDG PET examination more than 48 h since the last seizure, (c) no structural abnormalities associated with epilepsy detected on routine MRI Exclusion Criteria: (a) any history of other neurological or psychiatric disorders; (b) pre-scan plasma glucose level > 120 mg/dl before 18F-FDG PET/CT examination;(c) any contraindications for MRI examination ; (d) head movement (translation > 3 mm or rotation > 3 degree ) during MRI examination

Ages Eligible for Study
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Minimum Age: 6 Years
Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental Group<br>The experimental group underwent neuropsychological testing, 18F-FDG PET/CT, 3T resting state fMRI examinations. | |
| MRI Control Group<br>The MRI control group underwent neuropsychological testing and 3T resting state fMRI examinations | |
| PET Control Group<br>The PET control group underwent 18F-FDG PET/CT examination | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Processing speed index | Processing speed index was measured according to Wechsler Intelligence Scale for Children | Through study completion, about 2 years | 
| Standardized uptake value ratio | Standardized uptake value ratio was measured from 18F-FDG PET for brain glucose metabolism | Through study completion, about 2 years | 
| Functional connectivity | Functional connectivity was measured from fMRI for brain regional interactions | Through study completion, about 2 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Processing speed, Epilepsy, Positron emission tomography, Functional magnetic resonance imaging