The National Center for Testing Treatments in Chronic Spinal Cord and Traumatic Brain Injury

Study Overview
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Brief Summary
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The NCTT is a prospective, multicenter, observational research network for subjects with chronic spinal cord and/or chronic traumatic brain injury.

Detailed Description
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Current treatment for Spinal Cord Injury and Traumatic Brain Injury focuses on stabilizing the patient and preventing secondary injury with the aim of maximizing the best chance of recovery. Most patients will show varying amounts of recovery, but, when the injury is severe, that recovery is only partial. Enrollment in the NCTT will allow for classification and characterization of injury, function, co-morbidities, secondary issues/problems, research interests and will serve as a conduit for enrollment into interventional studies.

Official Title
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The National Center for Testing Treatments in Chronic Spinal Cord and Traumatic Brain Injury

Conditions
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Spinal Cord Injury, Traumatic Brain Injury

Intervention / Treatment
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* Other: Data and sample repository


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: History of spinal cord injury and/or brain injury Able to provide HIPAA authorization to share prior medical records/imaging Age 18 and older. Exclusion Criteria: Life expectancy less than 6 months, vegetative state or co-existing disease or other characteristic that precludes appropriate diagnosis of spinal cord or brain injury. Other condition that, in the opinion of the site investigator, would interfere with adherence to study requirements. Inability or unwillingness of subject or legal guardian/representative to give informed consent (e.g., ward of the state).

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Spinal Cord and Traumatic Brain Injury Subjects<br>Patients with a history of spinal cord and/or traumatic brain injury will provide data and samples so that they may be queried for interventional studies. | Other: Data and sample repository<br>* Subjects with spinal cord and/or traumatic brain injury, family members and healthy volunteers will provide data and samples.<br>|
| Family Members and Healthy Volunteers<br>Healthy volunteer controls or family members may be enrolled for identification of genetic mutations. | Other: Data and sample repository<br>* Subjects with spinal cord and/or traumatic brain injury, family members and healthy volunteers will provide data and samples.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| International Standard Neurological Classification of Spinal Cord Injury | functional ability (sensory and motor) for spinal cord injury subjects | greater than 6 months post-injury | 
| Disability Rating Scale | functional outcome scale for brain injury subjects | greater than 6 months post-injury | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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spinal cord injury, traumatic brain injury