The Effect of a Multi-component Weight Management Program on Appetite, Food Preference and Body Weight

Study Overview
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Brief Summary
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The aim of the current study is to demonstrate that a commercial weight management diet (i.e. low energy density) influences satiation, hunger and satiety and leads to lower energy intake during ad-libitum meals and over a full day. We further seek to demonstrate the sustainability of this effect following 12- week weight loss on the weight management program. We hypothesise that formulated (low energy) meals will lead to decreased hunger, greater fullness and reduced desire to eat compared to standard meals. We hypothesise that the commercial weight management program will lead to greater weight loss compared to control program. We hypothesise that formulated meals (high consumer acceptance) will improve hedonic control over eating (lower wanting for high fat food) We hypothesise that the commercial weight management program will improve hedonic control over eating (reduced experience food cravings)

Official Title
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The Effect of a Multi-component Weight Management Program on Appetite, Food Preference and Body Weight

Conditions
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Overweight, Obesity, Sedentary Lifestlye

Intervention / Treatment
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* Behavioral: Weight management program


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: BMI of 28 - 45 kg/m2 Reporting an interest in weight loss, not actively participating in a commercial weight loss program, Not increased physical activity levels in the past 2-4 weeks Able to eat most everyday foods and fruits and vegetables Written informed consent to be given Exclusion Criteria: Significant health problems that could cause confounding effects between intervention and control. Taking any medication or supplements known to affect appetite or weight within the past month and/or during the study Pregnant, planning to become pregnant or breastfeeding History of anaphylaxis to food Known food allergies or food intolerance Smokers and those who have recently ceased smoking Participants receiving systemic or local treatment likely to interfere with evaluation of the study parameters Those who have previously taken part in a commercial weight loss program in the last 6 months? . Participants who work in appetite or feeding related areas Participants unable to consume foods used in the study Participants who have had bariatric surgery Participants with a history of eating disorder Presence of untreated hypothyroidism Inability to fully comply with intervention or study procedures Insufficient English language skills to complete study questionnaires

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Intervention Group<br>Participants enrolled in commercial weight management program | Behavioral: Weight management program<br> <br> |
| Active Comparator: Control group<br>Participants enrolled in standard care weight management provision | Behavioral: Weight management program<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Test Meal Energy Intake | Measured reductions in ad-libitum energy intake following consumption of formulated test meal in comparison to control. | Week 0 and week 12 | 
| 24h Energy Intake | Measured reduction in total within-day energy intake following consumption of formulated meals in comparison to control | Week 0 and week 12 | 
| Appetite sensations | Measured reduction in hunger and increase in satiety quotient following consumption of formulated test meal in comparison to equi-energetic control | Week 0 and week 14 | 
| Food preference | Measured changes in food preference and liking and wanting profiles for food (HF<LF) following consumption of formulated test meal in comparison to equi-energetic control | Week 0 and week 14 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Body Weight | Measured change in weight and energy balance parameters over a 12 week period following participation in commercial weight management program compared to control group. | Weekly from week 0 to week 12 |