Firm Observational Clinical Unicenter Study on Guillain Barré Syndrome

Study Overview
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Brief Summary
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The aim of this retrospective observational single-center cohort study is to gain a deeper understanding regarding the frequency, the clinical and electrophysiologic characteristics (e.g., the diagnostic work up), complications, treatment regimes, and their associations with specific courses of disease and outcomes in adult patients with the suspected or proven diagnosis of GBS.

Detailed Description
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Guillain Barré Syndrome (GBS) is a rare and life-threatening neurological emergency. The aim of this retrospective study including adult GBS patients from the last 15 years treated at the University Hospital of Basel is to assess data regarding diagnostic workup, treatment, clinical course including complications and outcomes.

Official Title
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Firm Observational Clinical Unicenter Study on Guillain Barré Syndrome (FOCUS on GBS)

Conditions
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Guillain-Barre Syndrome (GBS)

Intervention / Treatment
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* Other: data collection


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: suspected diagnosis of GBS, who have been treated at the University Hospital of Basel from 01.01.2005-28.02.2021 Exclusion Criteria: Patients with documented refusal of the general consent.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: data collection|Retrospective extraction of demographic, clinical, laboratory, and electrophysiological data from the digital medical records|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| frequency of GBS | frequency of GBS of all consecutive adult patients with the suspected initial diagnosis of GBS (admitted to the University Hospital Basel) | one time retrospective assessment at baseline | 
| clinical characteristics of GBS | clinical characteristics of GBS of all consecutive adult patients with the suspected initial diagnosis of GBS (admitted to the University Hospital Basel) | one time retrospective assessment at baseline | 
| electrophysiologic characteristics of GBS | electrophysiologic characteristics of GBS of all consecutive adult patients with the suspected initial diagnosis of GBS (admitted to the University Hospital Basel) | one time retrospective assessment at baseline | 
| complications of GBS | complications of GBS of all consecutive adult patients with the suspected initial diagnosis of GBS (admitted to the University Hospital Basel) | one time retrospective assessment at baseline | 
| treatment regimes of GBS | treatment regimes of GBS of all consecutive adult patients with the suspected initial diagnosis of GBS (admitted to the University Hospital Basel) | one time retrospective assessment at baseline | 
| outcomes of GBS | treatment regimes of GBS of all consecutive adult patients with the suspected initial diagnosis of GBS (admitted to the University Hospital Basel) | one time retrospective assessment at baseline |