Development of Protocols and Methods for Image Processing and Enhancement of MRI Data

Study Overview
=================
Brief Summary
-----------------
The purpose of the study is to develop new Magnetic Resonance Imaging (MRI) protocols and methods for image processing and enhancement. Different setting of acquisition parameters used in conventional clinical MRI protocols will be defined, to create New Protocols. Then post-processing will be applied on new protocols to enhance the image quality. Finally a comparison of image quality will be performed to compare the image quality of images obtained by conventional protocols with those obtained with the New Protocols.

Official Title
-----------------
Development of Protocols and Methods for Image Processing and Enhancement of MRI Data

Conditions
-----------------
MRI Image Enhancement

Intervention / Treatment
-----------------
* Diagnostic Test: Imaging


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Volunteers for clinical MRI examination Patients undergoing clinical MRI examination Capable to provide an informed written consent form Exclusion Criteria: Any contraindication to MRI scanning, such as pacemakers or heart rhythm disturbances, permanent cosmetics or certain metallic implants in the body (excluding dental implants). Age <18 years old Pregnancy Claustrophobia

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: Imaging|MRI scanning using new protocols|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Image Signal to Noise Ratio (SNR) | Comparing the SNR of images obtained by conventional protocols with the corresponding New Protocols' processed images. The comparison will be performed by neuroradiologists, using a 7-point Likert-scale. Where higher the score, better the outcome (1 means unacceptable and 7 means excellent). | Through study completion, an average of 2 months. | 
| Image Resolution | Comparing the resolution of images obtained by conventional protocols with the corresponding New Protocols' processed images. The comparison will be performed by neuroradiologists, using a 7-point Likert-scale. Where higher the score, better the outcome (1 means unacceptable and 7 means excellent). | Through study completion, an average of 2 months. | 
| Artifacts | Comparing artifacts of images obtained by conventional protocols with the corresponding New Protocols' processed images. The comparison will be performed by neuroradiologists, using a 7-point Likert-scale. Where higher the score, better the outcome (1 means unacceptable and 7 means excellent). | Through study completion, an average of 2 months. | 
| MRI contrast | Comparing MR contrast of images obtained by conventional protocols with the corresponding New Protocols' processed images. The comparison will be performed by neuroradiologists, using a 7-point Likert-scale. Where higher the score, better the outcome (1 means unacceptable and 7 means excellent). | Through study completion, an average of 2 months. | 
| Diagnostic quality | Comparing diagnostic quality of images obtained by conventional protocols with the corresponding New Protocols' processed images. The comparison will be performed by neuroradiologists, using a 7-point Likert-scale. Where higher the score, better the outcome (1 means unacceptable and 7 means excellent). | Through study completion, an average of 2 months. |