Post Covid-19 Vaccination Development or Flare of ARD

Study Overview
=================
Brief Summary
-----------------
Many patients develop autoimmune diseases after covid-19 vaccination, whether related to the vaccination or not, is still under study. This study will describe potential flare of ARD after COVID-19 vaccination, whether it leads to activity or new MSK manifestations development.

Detailed Description
-----------------
-In this study: patients with known diagnosed rheumatic diseases who are vaccinated (one or full doses) of any type of COVID-19 vaccines will be enrolled. new ARD and prevalence of different MSK manifestations after covid-19 vaccinations also will be reported. The prevalence of flare of ARD after covid-19 vaccinations will be dteremined. Also we will compare between different types and doses of covid-19 vaccinations in inducing ARD or flares. Study Design: Cross sectional study Target population: any patient with pre-existing received any vaccination against covid-19 visiting rheumatology outpatient clinic. -any patient develops MSK manifestations after covid-19 vaccination. The disease activity sataus will be measured according to the type of rheumatic disease. For RA , disease activity score28 will be used, in lupus: SLEDAI, in Behcet : BDCAF, in SpA: BASDAI.

Official Title
-----------------
New or Flare of Musculoskeletal Rheumatic Diseases After Different COVID-19 Vaccines: Multicentre Study

Conditions
-----------------
COVID-19, Vaccination; Infection, Rheumatic Diseases

Intervention / Treatment
-----------------
* Biological: COVID-19 vaccination


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age above 18 years Vaccinated against covid-19 (one dose or fully vaccinated) Exclusion Criteria: Receiving other vaccine e.g influenza Less than 18 years old

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Biological: COVID-19 vaccination|different types of covid-19 vaccinations.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| -Prevalence of new ARD after covid-19 vaccinations | any ARD | 3 moths | 
| prevalence of flare of ARD after covid-19 vaccinations | flare of any manifestations of the disease | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prevalence of non-specific MSK symptoms after Covid-19 vaccine. | any MSK symptoms | 3 months | 
| Correlation of the MSK to the 1st and 2nd Covid vaccine dose | Correlation of the MSK to the 1st and 2nd Covid vaccine dose | 3 months | 
| comparison between different type of covid-19 vaccine in inducing ARD or flare up. | any type of flare | 3 months | 
| disease activity status in the patients who developed the ARD symptoms before and after the vaccine. | activity assessed by disease activity scores | 3 months | 
| Any correlation between the appearance of MSK symptoms and the patient's medications | current medications | 3 months |