Retrospective Descriptive Study of Platelet Transfusion in Patients With Palliative Hematologic Malignancies at the University Hospital of Besançon

Study Overview
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Brief Summary
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Development of palliative care is less effective for patients with hematologic malignancies. Limited data is available for end of life care in this population, moreover with thrombocytopenic patients. Thrombopenia is a frequent complication, specific of bone marrow involvement in those diseases or its treatments. Yet, a few studies was interested in, whereas platelet transfusion is the only treatment indicated. As it represent a scarce, limited resource, the ethical principles are in conflict in this setting. The purpose of this study was to describe retrospectively platelet transfusion in the six last few month of life of patients with hematologic malignancies at the CHU of Besançon (France) between 01/07/15 and 31/12/16.

Official Title
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Etude Descriptive Retrospective de la Transfusion Plaquettaire Chez Des Patients Atteints d'hémopathie Maligne en Phase Palliative et Suivis au CHU de Besançon

Conditions
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Platelet Transfusion, Palliative Care

Intervention / Treatment
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* Other: descriptive


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patient with hematological malignancies transfused in platelet at least once in the last 6 months of life hospitalised or follow up at the CHU of Besancon at least once dead during the period of the study Exclusion Criteria: patient with other oncologic malignancies not transfused in platelet in the last 6 months of life never hospitalised or follow up at the CHU of Besancon alive

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| patient transfused in platelet in the 6 last months of life<br>patient with hematological malignancies follow or hospitalised at least once in CHU of Besancon died in the period of the study transfused at least once in the 6 months of life | Other: descriptive<br>* evaluate in number and efficacy platelet transfusion at the end of life, demographic characteristic are also noted<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| evaluate frequency of platelet transfusion at the end of life | to calculate the number of platelet transfusion at the end of life. The number of platelet transfusion between 6 months and death are collected in each periods of 2 weeks to calculate the number of transfusion per patient during each 2 weeks. | 18 months (between 07/01/2015 and 12/31/2016) | 
| evaluate efficacy of prophylactic platelet transfusion at the end of life | to calculate the platelet yield in percentage | 18 months (between 07/01/2015 and 12/31/2016) | 
| evaluate efficacy of non prophylactic platelet transfusion at the end of life | to calculate the transfusional interval between 2 platelet transfusion in days | 18 month (between 07/01/2015 and 12/31/2016) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| demographic characteristic | characteristic of patient (age, diagnosis,location of death, palliative care received...) | 18 months (between 07/01/2015 and 12/31/2016) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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platelet transfusion, palliative care