Natriuresis as a Predictor of the Haemodynamic Response to Steroid Replacement Therapy in Patients in Septic Shock

Study Overview
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Brief Summary
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Septic shock is responsible in 20% of cases of acute adrenal insufficiency and in 50% of cases of chronic 'slow' adrenal insufficiency. Given the unpredictable nature of the response to the ACTH stimulation test, it is recommended to systematically start steroid replacement therapy with hydrocortisone hemisuccinate (HCHS) in patients in septic shock who do not respond to fluid resuscitation and who continue to suffer from haemodynamic instability despite increasing doses of noradrenaline. The interest of this corticosteroid therapy lies in its ability to reduce the duration of treatment with catecholamines, though the results are conflicting with regard to an eventual benefit for mortality. Steroid replacement therapy may be deleterious. It may increase the risk of sepsis and secondary septic shock. It is also implicated in critical-illness polyneuropathy and blood glucose dysregulation. Today, there is no way to identify a population of patients who respond to corticosteroid therapy. From a pathophysiological viewpoint, HCHS, as well as its glucocorticoid effects, may also exert mineralocorticoid effects able to compensate for the impaired renin angiotensin aldosterone system (RAAS), which is responsible for the refractory aspects of septic shock. This hyperreninism-hypoaldosteronism is found with a prevalence of around 50% of cases and is defined by a plasma aldosterone/ plasma renin ratio < 2. It is associated with natriuresis >30 mmol/l. We hypothesise that natriuresis > 30 mmol/l will make it possible to identify patients who respond to steroid replacement therapy in terms of catecholamine use.

Official Title
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Natriuresis as a Predictor of the Haemodynamic Response to Steroid Replacement Therapy in Patients in Septic Shock

Conditions
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Septic Shock

Intervention / Treatment
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* Biological: Aldosterone / renin dosage
* Biological: Natriuresis


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: persons who have consented to take part Patients aged 18 to 85 years Admitted to an ICU for a first episode of septic shock With a dose of noradrenaline ≥ 0.25µg/kg/min Undergoing treatment with Hydrocortisone Hemisuccinate (HCHS) Exclusion Criteria: Adult under guardianship Patients without national health insurance cover Pregnant or breast-feeding women Immunodepression (AIDS, corticosteroid treatment > 3 weeks, Organ graft, treatment with immunosuppressants) Recent intake of diuretics (< 6 h) Long-term ACE inhibitors or ARAII Chronic kidney failure (clearance < 60) Cirrhosis Child ≥ B Chronic heart failure (NYHA III and IV) Decision to limit or to stop treatment

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Biological: Aldosterone / renin dosage|Plasma levels of aldosterone and renin|
|Biological: Natriuresis|natriuresis levels|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Variation in doses of noradrenaline |  | Day 3 |