Outcome of Patients With Thoraco-abdominal Injury and Stress-induced Hyperglycemia or Diabetic Hyperglycemia

Study Overview
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Brief Summary
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This study aimed to measure the effects of SIH and DH on the mortality outcomes of the adult patients with moderate to severe thoracoabdominal injury

Detailed Description
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Because the pathophysiologic response of the patients with a thoracoabdominal injury is different from those who had a traumatic brain injury, this study aimed to measure the effects of hyperglycemia induced by stress or by diabetes on the outcomes of patients with thoracoabdominal injuries in comparison with those who had non-diabetic normoglycemia (NDN). The primary study hypothesis stated that, following thoracoabdominal injuries, the patients with SIH had a worse outcome than patients with DH. The primary outcome was mortality rate of these patients.

Official Title
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Admission Hyperglycemia in Patients With Moderate to Severe Thoracoabdominal Injuries is Associated With Higher Mortality Rate Than Non-Diabetic Normoglycemic Patients

Conditions
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Abdominal Injury, Thoracic Injury, Hyperglycemia, Hyperglycemia Stress

Intervention / Treatment
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* Other: Stress-induced hyperglycemia
* Other: Diabetic hyperglycemia
* Other: Diabetic normoglycemia
* Other: Non-diabetic normoglycemia


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: adult patients with moderate to severe thoracoabdominal injuries Exclusion Criteria: patients with a thoracic and abdominal abbreviated injury scale (AIS) < 3 patients who had polytrauma which was defined as there was additional AIS scores ≥ 3 points in other regions of the body patients less than 20 years old patients who had sustained a burn injury

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 100 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| adult patients with thoracoabdominal injuries<br>adult patients with moderate to severe thoracoabdominal injuries | Other: Stress-induced hyperglycemia<br>* Stress-induced hyperglycemia (SIH)was defined as a serum glucose ≥ 200 mg/dL in the patients without Diabetes mellitus.<br>Other: Diabetic hyperglycemia<br>* Diabetic hyperglycemia (DH) which indicated a serum glucose ≥ 200 mg/dL in patients with Diabetes mellitus.<br>Other: Diabetic normoglycemia<br>* Diabetic normoglycemia (DN), which was defined when there was a serum glucose < 200 mg/dL in the patients with Diabetes mellitus.<br>Other: Non-diabetic normoglycemia<br>* Non-diabetic normoglycemia (NDN) indicating a serum glucose < 200 mg/dL in patients who were absent of Diabetes mellitus.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| in-hospital mortality | The primary outcome of the study was in-hospital mortality. | up to 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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admission hyperglycemia, stress-induced hyperglycemia, diabetic hyperglycemia, diabetes mellitus, thoracoabdominal trauma, mortality