Study of Human Papillomavirus Related Genital Pathology Among HIV Positive Women

Study Overview
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Brief Summary
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This study is a Multicentre cohort study with inclusion throughout the full duration of the study. The primary objective is the study of human papillomavirus related genital pathology in HIV positive women. The secondary objective are: To study the characteristics of HPV infection and related disease in the context of long term HAART and HIV infection ; To study the characteristics of atypical cells of uncertain significance detected in Pap smears, whose prevalence has dramatically increased in the last years; To describe cervical cancers observed in the cohort To study the evolution of recurrent high-grade lesions after surgery To describe the evolution of vaginal lesions developed after hysterectomy for high-grade lesions ; To describe the specific aspects of surgery for the treatment of cervical lesions according to the specific localization in the endocervix in HIV-positive women ; To study the in situ T cell HPV specific response in cervical lesions and the relationship between virological and clinical parameters, host immune status and natural history of lesions ; To initiate a prospective study on anal HPV infection and related disease among women infected with HIV. To initiate a study on therapeutic and/or prophylactic HPV vaccines in the context of immunosuppression and a high rate of HPV infection ;

Detailed Description
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Data were be collected into evaluate: Analysis of prognostic factors (CD4, antiviral therapy) of cervical lesions, using Cox models. Estimation of rates of Incidence of high grade lesions, of recurrence after surgical treatments using Kaplan Meier tests. Logistic regression analysis for the study of factors associated with complete excision after surgical treatment. SIR (standardised incidence rate) evaluation for cervical cancer Study procedures are Annual follow-up in case of normal Pap smear, biannual follow-up in case of cervical lesions. Surgical management of High grade lesions.

Official Title
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Study of Human Papillomavirus Related Genital Pathology Among HIV Positive

Conditions
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HIV Infections

Intervention / Treatment
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* Procedure: surgical management of high grade lesions


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: women > 18 years old attending outpatient gynecology consultation HIV positive with written informed consent on social security Exclusion Criteria: unaffiliated to the social healthy security french system

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: surgical management of high grade lesions|Clinical, pathological and biological, data at diagnosis and during follow-up will be collected. Surgical sample will be collected to study human papillomavirus related genital pathology.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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human papillomavirus, follow up