Yonsei OCT (Optical Coherence Tomography) Registry for Evaluation of Efficacy and Safety of Coronary Stenting

Study Overview
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Brief Summary
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Optical coherence tomography (OCT) has been recently studied for evaluation of coronary stenting. Because of high resolutions, several reports have shown that OCT is appropriate for evaluating neointimal tissue after coronary stent implantation. Also, the strut coverage and the characterization of neointimal tissue can be accurately evaluated. Furthermore, OCT-defined coverage of a stent strut was proposed to be related with clinical safety in drug-eluting stents-treated patients. Therefore, the investigators will evaluate the appropriateness of currently using coronary stents (e.g. Sirolimus eluting stent, Paclitaxel-eluting stent, Zotarolimus-eluting stent, Everolimus-eluting stent, Biolimus eluting stent, EPC(endothelial progenitor cell) Capture stent, etc) based on the findings of OCT. Additionally, the investigators will evaluate neointimal hyperplasia, malposition or strut coverage to decide the differences in the stent characteristics, the duration of antiplatelet use, and the differences according to the clinical presentations.

Conditions
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Coronary Artery Disease, Ischemic Heart Disease

Intervention / Treatment
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* Device: coronary stents


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with coronary stents Patients who will have coronary stents because of coronary artery stenosis Exclusion Criteria: Hemodynamically unstable patients Ostial lesions that begin within 15 mm of the left main coronary artery Lesions with diameter more than 4 mm Patients with allergy to antiplatelet agent (asprin or clopidogrel) Patients with hepatic dysfunction (Liver enzyme 3 times the upper limit of normal) Pregnant and lactating patients Patients with life expectancy less than 1 year

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: coronary stents|e.g. Sirolimus eluting stent, Paclitaxel-eluting stent, Zotarolimus-eluting stent, Everolimus-eluting stent, Biolimus eluting stent, EPC(endothelial progenitor cell) Capture stent, etc|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| OCT findings (stented lesions, native vessels) |  | at index PCI, at follow-up coronary angiography (3, 6, 9 or 12 months and at the time clinically indicated) | 
| Clinical outcomes | Death, Cardiac death, Stent thrombosis, Myocardial infarction, Target-lesion revascularization, Target-vessel revascularization | up to 10 years | 
| Comparison of OCT findings with physiologic findings |  | at index PCI, at follow-up coronary angiography (3, 6, 9 or 12 months and at the time clinically indicated) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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OCT, Coronary, Stenting