Acupoint Stimulation Alleviates Postoperative Nausea and Vomiting

Study Overview
=================
Brief Summary
-----------------
Incidence of postoperative nausea and vomiting (PONV) could be high as 60% after liver surgery. Acupoint stimulation has been proved to decrease PONV. In this study, we will investigate the effect of transcutaneous electrical acupoint stimulation on incidence of PONV after liver surgery.

Official Title
-----------------
Effect of Transcutaneous Electrical Acupoint Stimulation on Postoperative Nausea and Vomiting After Liver Surgery

Conditions
-----------------
PONV

Intervention / Treatment
-----------------
* Device: transcutaneous electrical acupoint stimulation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age ≥18 years scheduled for elective liver surgery under general anesthesia Exclusion Criteria: body mass index less than 18 kg/m2 or higher than 30 kg/m2 American Society of Anesthesiologists status higher than Ⅲ patients with contraindication to transcutaneous electrical stimulation, including skin damage, infection or implantable electrical device suspected or existed abuse of drug or alcohol pregnant or breeding women history of neurological or psychiatric disease

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: transcutaneous electrical acupoint stimulation<br> | Device: transcutaneous electrical acupoint stimulation<br>* Electrodes are placed at acupoints and connected to the stimulator. Electrical stimulation is given during surgery.<br>* Other names: TEAS;|
| No Intervention: Control<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| incidence of nausea and vomiting by 24 hours after surgery |  | from end of surgery to 24 hours after surgery, in a total of 24 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| incidence of nausea and vomiting by 48 hours after surgery |  | from end of surgery to 48 hours after surgery, in a total of 48 hours | 
| incidence of nausea and vomiting in PACU (post-anesthesia care unit) |  | from end of surgery to discharge from PACU(post-anesthesia care unit), in an average of 30 minutes | 
| score of nausea and vomiting by 24 hours after surgery |  | from end of surgery to 24 hours after surgery, in a total of 24 hours | 
| score of nausea and vomiting by 48 hours after surgery |  | from end of surgery to 48 hours after surgery, in a total of 48 hours | 
| score of nausea and vomiting in PACU(post-anesthesia care unit) |  | from end of surgery to discharge from PACU, in an average of 30 minutes | 
| Quality of recovery score at 24 hours after surgery |  | from end of surgery to 24 hours after surgery, in a total of 24 hours | 
| Quality of recovery score at 48 hours after surgery |  | from end of surgery to 48 hours after surgery, in a total of 48 hours | 
| postoperative in-hospital stay |  | from end of surgery to discharge from hospital, in an average of 7 days | 
| death by 6 months after surgery |  | from end of surgery to 6 months after surgery, in a total of 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
transcutaneous electrical acupoint stimulation, liver surgery