Brain, Brainstem, and Spinal Cord fMRI

Study Overview
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Brief Summary
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New advances in medical imaging have allowed for the measurement of brain activity related to chronic pain. In addition to the brain, the investigators aim to use functional magnetic resonance imaging to investigate pain processing in the brainstem and spinal cord in healthy subjects and chronic neck pain patients. The information gained from this study will increase the investigators understanding of how chronic pain is encoded in the nervous system and assist in developing more effective treatment strategies.

Detailed Description
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The experimental design is an observational (non-interventional) cross-sectional clinical study. The principal goal of the proposed research is to utilize functional magnetic resonance imaging to further investigate and characterize pain-related neural activity at the level of the brain, brainstem, and spinal cord in healthy subjects and chronic neck pain patients. Healthy subjects and chronic neck pain patients will be recruited and participate in a single session of data collection. For both the healthy and chronic neck pain groups, painful thermal stimuli will be applied over the skin of the upper extremity while whole brain, brainstem, and cervical spinal cord functional images are acquired (on separate scans). For the chronic neck pain group, additional scans (brain, brainstem, and cervical spinal cord) will be acquired while the subjects rate their spontaneous chronic neck pain.

Official Title
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Investigating Pain Processing in the Brain, Brainstem, and Spinal Cord With fMRI

Conditions
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Neck Pain, Chronic Pain

Intervention / Treatment
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* Other: Functional Magnetic Resonance Imaging


Participation Criteria
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Eligibility Criteria
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Healthy subjects must meet all of the following inclusion criteria to participate in this study: Age between 21 and 60 years old Right-handed; not currently experiencing significant pain No history of a chronic pain syndrome such as fibromyalgia, complex regional pain syndrome, chronic low back pain, etc. Chronic neck pain patients must meet all of the following inclusion criteria to participate in this study: Age between 21 and 60 years old Right handed; neck pain > 3 months duration; moderate neck pain score > 30 on VAS (0-100) 3) No history of a chronic pain syndrome (fibromyalgia, complex regional pain syndrome, chronic low back pain, etc.) other than chronic neck pain and its associated symptoms. Participants meeting any of the following exclusion criteria at baseline will be excluded from study participation: Non-English speaking Signs of upper extremity sensation loss; history of significant cerebrovascular disease including (but not limited to) epilepsy, stroke, tumor, multiple sclerosis, meningitis History of major head trauma with sustained loss of consciousness; history of neurosurgery, ENT surgery, spine surgery, or cardiac surgery History of cardiac pacemaker or neurostimulator implantation History of significant medical illness including cardiovascular disease, uncontrolled diabetes, uncontrolled hypertension, cancer, chronic obstructive pulmonary disease, severe asthma requiring hospitalization for treatment, renal insufficiency requiring dialysis, etc. History of alcoholism or consistent drug use; current infection or fever; pregnancy (or possible pregnancy) History of metal working or injury with shrapnel or metal slivers Claustrophobia Piercings that are unable to be removed and tattoos older than 30 years

Ages Eligible for Study
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Minimum Age: 21 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Healthy subjects<br>Functional magnetic resonance imaging of healthy subjects | Other: Functional Magnetic Resonance Imaging<br>* Functional magnetic resonance imaging will be performed to measure brain, brainstem, and spinal cord activity.<br>|
| Chronic neck pain patients<br>Functional magnetic resonance imaging of chronic neck pain patients | Other: Functional Magnetic Resonance Imaging<br>* Functional magnetic resonance imaging will be performed to measure brain, brainstem, and spinal cord activity.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Functional magnetic resonance imaging | Use functional magnetic resonance imaging to characterize brain, brainstem, and spinal cord pain processing in healthy subjects (thermal pain) and chronic neck pain patients (thermal pain and spontaneous clinical pain). | 1.5-2.25 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Neurophysiology, Magnetic Resonance Imaging, Brain, Brain Stem, Spinal Cord