Spontaneous Coronary Artery Dissection Registry (DIssezioni Spontanee COronariche ITalian-SPAnish)

Study Overview
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Brief Summary
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The study will investigate the clinical features, acute management and follow up of patients affected by spontaneous coronary artery dissection

Detailed Description
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Spontaneous Coronary Artery Dissection is now being increasingly studied as it is getting more and more relevant as a cause of ACS. Its management is currently a matter of debate due to the absence of RCT and even the trigger events related to this kind of infarction are still unclear. Notably, the benefits from the use of the antiplatelet medications that prolong bleeding time for a condition whose primary pathophysiology may be an intramural bleed are under discussion. Hence, the targets pursued by our study may be essentially distinguished in five main points: To assess the characteristics of SCAD patients highlighting the predisposing and precipitating factors related to the acute event To analyze clinical presentation and management of spontaneous coronary dissections in terms of therapeutic approach in the acute phase (conservative therapy vs revascularization) To evaluate the incidence of SCAD recurrence and of major adverse cardiovascular events (MACEs) at follow-up To analyze the impact of a single antiplatelet therapy (SAPT) over the dual one (DAPT) along with the impact of different P2Y12i regimens on acute and long-term prognosis To evaluate impact of different angiographic SCAD type on outcome

Official Title
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A Multicenter Italian and Spanish Observational Registry on Patients Affected by Spontaneous Coronary Artery Dissection (SCAD)

Conditions
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Spontaneous Coronary Artery Dissection

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Consecutive patients with a novel diagnosis of Spontaneous Coronary Artery Dissection (SCAD) Exclusion Criteria: Age <18 year old or inability to provide Informed Consent

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Major Cardiovascular Cardiac Events (a composite of all-cause of death, non-fatal Myocardial Infarction (MI) and any unplanned revascularization either percutaneous or surgical) | Major Cardiovascular Cardiac Events occurring within 12 months | 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| all-cause of death | all-cause of death | 12 months | 
| non-fatal Myocardial Infarction (MI) | non-fatal Myocardial Infarction (MI) | 12 months | 
| any unplanned revascularization either percutaneous or surgical | any unplanned revascularization either percutaneous or surgical | 12 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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SCAD, Spontaneous coronary artery dissection