linjc16/ctgov huggingface dataset:
The Multifunctional Image Guided Therapy Suite (MIGTS) in Emergency Multiple Trauma Care

Study Overview
=================
Brief Summary
-----------------
Controlled clinical intervention study comparing the treatment of multiple trauma patients in a newly developed combined diagnostic and operation room, the multifunctional image guided therapy suite (MIGTS) versus controls. The MIGTS proved to significantly accelerate the procedure and led to more satisfied team members.

Detailed Description
-----------------
Objective: Pilot evaluation to which extend the implementation of a newly developed combined diagnostic and operation room, the multifunctional image guided therapy suite (MIGTS) may influence the emergency treatment of multiply injured patients. Summary Background: Controlled data on the impact of modern technology integration in multiple trauma management and involved care providers are lacking. Methods: Quasi-randomized clinical intervention study comparing the treatment of multiple trauma patients (injury severity score, ISS >16) in the MIGTS versus controls.

Official Title
-----------------
The Impact of a Multifunctional Image Guided Therapy Suite (MIGTS) on Emergency Multiple Trauma Care - a Controlled Clinical Pilot Study

Conditions
-----------------
Acceleration of Procedure, Reduction of Number of Transports and Transfers, Involved Staff Member's Evaluation

Intervention / Treatment
-----------------
* Procedure: MIGTS treatment


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: multiple trauma with at least two abbreviated injury scoring (AIS) regions involved and injury severity score (ISS)>16 primary hospital treatment at University Hospital Basel Exclusion Criteria: monotrauma or ISS < 16 or prior treatment in another hospital
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: MIGTS treatment<br>controlled trial (quasi-randomized) versus controls (=conventional treatment not in the MIGTS) | Procedure: MIGTS treatment<br>* treatment of multiple trauma patients in the MIGTS<br>* Other names: combined diagnostic and operation room;|
| No Intervention: controls (=conventional treatment not in the MIGTS)<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time to first CT scan |  | first CT scan after arrival of emergency patient | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Staff member evaluation (Likert scale 1-5) |  | end of emergency treatment (arrival ICU or death) | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
multiple trauma, outcome and process assessment
Muscle and Cerebral Oxygenation Under EVAR of AAA: GA vs LA

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine the effect of General versus Local Anaesthesia on muscle and cerebral oxygenation under EVAR-treatment in a prospective unblinded randomised controlled trail.

Official Title
-----------------
Muscle and Cerebral Oxygenation Under Endovascular Aortic Repair (EVAR) of Abdominal Aortic Aneurysm: General Versus Local Anesthesia - an Randomised Controlled Trial Study

Conditions
-----------------
Anesthesia

Intervention / Treatment
-----------------
* Procedure: Local Anesthesia


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 18 years or older Scheduled procedure Exclusion Criteria: allergies for used local anaesthesia have had vascular surgery before in the femoral area the need for thromboendarterectomy in common femoral artery the need for aortouniiliac stent-graft with cross-over bypass severe back pain expected time of surgery more than 1.5 hour cognitive dysfunction making cooperation during procedure impossible Femoral amputee

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: General Anaesthesia<br>EVAR-treatment is preformed with the patient in General Anaesthesia | |
| Experimental: Local Anaesthesia<br>EVAR-treatment is preformed with the patient in Local Anesthesia | Procedure: Local Anesthesia<br>* Use of unspecified local anaesthesia (fx lidocain or bupivacaine)<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Near-Infrared Spectroscopy-determined Cerebral Oxygenation |  | participants will be followed for the duration of hospital stay, an expected average of 5 days | 
| Near-Infrared Spectroscopy-determined Muscle oxygenation |  | participants will be followed for the duration of hospital stay, an expected average of 5 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Spectroscopy, Near-Infrared, Endovascular Procedures, Local Anesthesia, General Anesthesia
Anti-psoriatic Effect of TL01 Light Therapy

Study Overview
=================
Brief Summary
-----------------
This is a pilot study to investigate the effect of TL01 narrow band UVB therapy on the resident dermal dendritic cells characterized by expression of CD1c and CD141. These cells were reported to have a role in induction of tolerogenic regulatory T cells and production of IL-10. The investigators proposed to investigate the effect of NB-UVB on these subsets of cells after two weeks of treatment to provide better understanding of the mechanism of action of light treatment.

Detailed Description
-----------------
Six patients with plaque psoriasis were recruited from the phototherapy unit. These patients were referred by their dermatologist to receive narrow-band UVB (TL01) light treatment. Two 6 mm lesional skin punch biopsies were taken at baseline and 2 weeks after commencing the light treatment to study the effect of light on innate immune cells involved in psoriasis pathogenesis.

Official Title
-----------------
Studying the Effect of Narrow Band Ultraviolet B Phototherapy on Skin Dendritic (DCs) Cells in Psoriasis Patients

Conditions
-----------------
Psoriasis

Intervention / Treatment
-----------------
* Device: TL01 light treatment


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Male and female psoriasis patients in whom the decision to treat with NB-UVB therapy, as part of their routine clinical care, has been taken by their dermatologist in the age range of 18-70 years. Exclusion Criteria: patients currently on antipsoriatic treatment. Patients with immunosuppressive diseases Patients on immunosuppressive therapies Pregnant or lactating female patients Patients unable to provide a written consentProcedure

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: TL01 light treatment<br>routine treatment with a CE marked device that has been used for this disease for many years | Device: TL01 light treatment<br>* Patients received treatment in TL01 cabinet three sessions weekly according to a standard escalating protocol based on minimal erythema dose. Standard dose ranges between 0.55 and 3.13J/cm2.<br>* Other names: Waldmnn Gmbh cabinet;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| determination of the effect of TL01 NB-UVB on numbers of CD1c and CD141 cells | no adverse events recorded after two weeks of TL01 treatment | 3 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
psoriasis patients referred to receive TL01 NB-UVB therapy
Effect of Bronchodilatator Testing on Multiple-breath-washout (MBW) Derived Lung Function Parameters

Study Overview
=================
Brief Summary
-----------------
The investigators aim to evaluate the effect of bronchodilatator testing on multiple-breath-washout derived lung function parameters.

Official Title
-----------------
Effect of Bronchodilatator Testing on Multiple-breath-washout (MBW) Derived Lung Function Parameters

Conditions
-----------------
Obstructive Ventilation Disorders

Intervention / Treatment
-----------------
* Device: multiple-breath-washout test
* Drug: Bronchodilator Agents


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: known or suspected obstructive ventilation disorder clinical indication for bronchodilator testing Exclusion Criteria: pregnancy inability to participate

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| obstructive ventilation disorder<br>patients with known or suspected obstructive ventilation disorder and clinical indication for bronchodilator testing | Device: multiple-breath-washout test<br> <br> Drug: Bronchodilator Agents<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change of lung clearance index (LCI) as determined by multiple breath washout |  | 60 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| repeatability of lung clearance index (LCI) |  | 60 minutes |
An Efficiency/Safety Study of Surgical Tissue Glue to Treat Inguinal Hernias

Study Overview
=================
Brief Summary
-----------------
Prospective, multicenter, observational registry to collect data of laparoscopic inguinal hernia repair using surgical tissue glue fixation. The objective is to determine the prevalence of chronic pain at 1 year.

Official Title
-----------------
Cyanoacrylate Fixation for Laparoscopic Repair of Inguinal Hernias: a Prospective, Multicenter Registry

Conditions
-----------------
Inguinal Hernia

Intervention / Treatment
-----------------
* Device: Mesh fixation with surgical tissue glue


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patient is older than 18 years. Written informed consent is obtained from patient. Patient is able to complete the EQ-5D questionnaire. Patient has a primary unilateral or primary bilateral inguinal hernia- Mesh fixation is established with solely surgical tissue glue (Ifbond™). Exclusion Criteria: Patient has a recurrent inguinal hernia. Patient is treated using the Lichtenstein technique. Mesh fixation with sutures, tacks, absorbable tacks or clips. Patient is allergic to components of surgical tissue glue (Ifbond™). Patient has a life expectancy of less than 1 year.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patient group<br>Administration of surgical tissue glue. | Device: Mesh fixation with surgical tissue glue<br>* Laparoscopic inguinal hernia repair using surgical tissue glue for mesh fixation<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative pain | Prevalence of postoperative pain evaluated by patient self-assessment using a visual analog scale. | up to 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Intraoperative complications | Complications such as bowel injury, major bleeding, complications due to anesthesia, nerve damage, lesion of vas deferens. | 1 day | 
| Postoperative complications | Local numbness, hematoma, seroma, wound infection, mesh infection, hernia recurrence. | Up to 30 days after index-procedure | 
| Analgesic intake | Intake of analgesics. | Discharge, 5 weeks | 
| Quality of life (QOL) | QOL assessed by EQ-5D questionnaire. | Preoperative, 5 weeks, 1 year | 
| Freedom from hernia-related reinterventions | Reinterventions at 1 year after index-procedure assessed by means of a questionnaire. | 1 year | 
| Late complications | Local numbness, groin discomfort, hernia recurrence, sexual dysfunction | 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Inguinal hernia, Laparoscopy, Surgical tissue glue
The Longitudinal Study of Low Anterior Resection Syndrome in Patients With Newly Diagnosed Rectal Cancer.

Study Overview
=================
Brief Summary
-----------------
The aims are to identify the trajectory of LAR Syndrome and explore the adaptation process and coping strategies of LAR Syndrome in patients newly diagnosed with rectal cancer. The participants will recruit from a CRC surgical outpatient department of a medical center in northern Taiwan.

Official Title
-----------------
The Longitudinal Study of Low Anterior Resection Syndrome, Psychological Distress, and Fecal Incontinence-related Quality of Life in Patients With Newly Diagnosed Rectal Cancer.

Conditions
-----------------
Rectal Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with stage I to III rectal cancer. Patients already know their condition. 4. Aged 20 years and older. 5. Consciously communicate in Mandarin or Taiwanese. 6. Agreed with the interview and had signed the permit. Exclusion Criteria: Patients with Stage IV rectal cancer. Recurred rectal cancer.

Ages Eligible for Study
-----------------
Minimum Age: 20 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Self-report Questionnaire | show the specific trajectory of LAR Syndrome, psychological distress, and fecal incontinence-related QoL based on different tumor locations in patients with rectal cancer | Change from baseline symptom at 12 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
low anterior resection syndrome, psychological distress, quality of life, rectal cancer
Evaluation of Salivary Level of miR-155 and IL-10 in Oral Lichen Planus Patients Before and After Treatment With Topical Corticosteroid

Study Overview
=================
Brief Summary
-----------------
Thirty patients will be recruited from the outpatient clinic of the faculty of dentistry.fifteen systemically healthy individuals with normal mucosa and fifteen atrophic/erosive oral lichen planus patients. Oral lichen planus patients will be treated with a topical steroid and miR-155 and IL-10 will be assessed in saliva before and after 4 weeks of topical steroids use

Official Title
-----------------
Evaluation of Salivary Levels of miR-155 and IL-10 in Oral Lichen Planus Patients Before and After Treatment With Topical Corticosteroid

Conditions
-----------------
Oral Lichen Planus

Intervention / Treatment
-----------------
* Drug: Triamcinolone Acetonide in orabase


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients clinically and histopathologically diagnosed as having atrophic/erosive OLP. Patients free from any other oral lesions cooperative patients who agrees to take the supplied medications. Patients who are systemically healthy Exclusion Criteria: Patients suffering from any systemic disease. Treatment with any systemic treatment such as systemic steroids, other immunosuppressive drugs or non-steroidal anti-inflammatory drugs at least eight weeks. Treatment with any oral topical medications for at least four weeks prior to the study. Pregnant and lactating women.

Ages Eligible for Study
-----------------
Minimum Age: 30 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| OLP patients<br>fifteen patients with atrophic /erosive OLP will receive treatment with topical triamcinolone acetonide in orabase 1mg/g 3 times /day and assessed every week for 4 weeks | Drug: Triamcinolone Acetonide in orabase<br>* treatment of OLP with topical steroid<br>* Other names: topical corticosteroid;|
| Control group<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measurement of salivary levels of miR-155 in OLP before treatment | assessment of miR-155 in saliva of patients with OLP before treatment | baseline | 
| Measurement of salivary levels of IL-10 in OLP before treatment | assessment of IL-10 in saliva of patients with OLP before treatment | baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measurement of salivary levels of miR-155 in OLP after treatment | assessment of miR-155 in saliva of patients with OLP after treatment | 4 weeks | 
| Measurement of salivary levels of IL-10 in OLP after treatment | assessment of IL-10 in saliva of patients with OLP after treatment | 4 weeks |
An Assessment of Aspirin Plus Prednisone Treatment for Euthyroid Women With Thyroid Autoimmunity

Study Overview
=================
Brief Summary
-----------------
Thyroid autoimmunity(TAI) per se have adverse effect on pregnancy outcomes，and aspirin and prednisone were used frequently in antithyroid antibodies(ATA) positive infertile women in clinical practice, but the impact of these medicines is still controversial. Therefore, aim of the study was to investigate whether or not the treatment of prednisone in addition to aspirin was capable of improving reproductive outcomes in euthyroid infertile women.

Detailed Description
-----------------
A multicenter retrospective study performed during the period of 2017 to 2020 and euthyroid infertile women positive for anti-thyroperoxidase antibody (TPOAb) and/or thyroglobulin antibody (TgAb) alone with thyroid stimulating hormone 0.35-4.0mIU/L undergoing first in vitro fertilization and embryo transfer(IVF-ET) cycle were recruited in our study.Data analysis was performed using the Statistics Package for Social Sciences.In the end, the value of prednisone plus aspirin treatment was investigated to make a big contribution on clinical practice.

Official Title
-----------------
An Assessment of Aspirin Plus Prednisone Treatment for Euthyroid Women With Thyroid Autoimmunity Undergoing In Vitro Fertilization

Conditions
-----------------
Thyroid Diseases

Intervention / Treatment
-----------------
* Drug: Prednisone 10 MG+aspirin 100MG


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Both TPOAb and TgAb in all the subjects were measured before ART procedure Thyroid stimulating hormone (TSH) level ranged from 0.35-4.0mIU/L Women underwent first embryo transfer without previous IVF history. Exclusion Criteria: Abnormal thyroid function test Women with known autoimmune diseases or clinical presentations of autoimmune disorders

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| control group<br> | |
| P+A group<br>aspirin: tablet 100mg qd 2-5weeks prednisone: tablet 10mg qd 2-5weeks | Drug: Prednisone 10 MG+aspirin 100MG<br>* Discontinue medication based on early pregnancy outcome<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| clinical pregnancy rate | Clinical pregnancy was defined as the existence of a viable embryo within an intrauterine gestational sac | 3 mouths | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Prednisolone, Assisted reproductive technology, Aspirin, thyroid diseases