Changes in Nasal Patency With Changes in Posture, Temperature, Humidity and Nasal Patency Seen by Acoustic Rhinometry

Study Overview
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Brief Summary
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To study nasal physiologic responses to changes in posture, temperatures, humidity and nasal patency with acoustic rhinometry.

Detailed Description
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The purpose of this study was to utilize acoustic rhinometry to assess changes in nasal patency after alterations in posture, unilateral mechanical obstruction, temperature, and humidity. Eight healthy adult volunteer subjects underwent acoustic rhinometry under the following conditions: 1) upright, sitting position (control), 2) supine position, 3) left lateral recumbent position, 4) one nostril mechanically blocked, 5) icepack on neck, 6) drinking cold water, 7) drinking hot water, 8) nasal nebulizer, 9)oxymetazoline decongestant. Changes in nasal cavity volumes were detected by acoustic rhinometry after alterations in posture, unilateral mechanical obstruction, temperature, and humidity. Nebulizer treatment and hot water ingestion caused a significant decrease in nasal volume. The nose was able to adapt to environmental and physiological changes in order to maintain a consistent total nasal volume.

Official Title
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Physiological Changes in Nasal Patency in Response to Changes in Posture, Temperature, Humidity and Nasal Patency Measured by Acoustic Rhinometry

Conditions
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Mucosal Congestion

Intervention / Treatment
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* Procedure: Acoustic rhinometry (procedure)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy volunteers, 18-58 years old Exclusion Criteria: Any nasal symptoms in the last 3 weeks Marked septal deviation/polyposis/infection Any history of allergy, asthma or immunodeficiency Any systemic condition or infection (e.g., hypertension/diabetes/heart, liver, thyroid or kidney disease Any spine or neck condition that would not allow normal postures Pregnancy

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 58 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Acoustic rhinometry (procedure)|Acoustic rhinometry is a procedure that uses sound waves to measure the cross-sectional area and volume of the nasal cavity.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in nasal patency |  | 5-10 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Nasal volume |  | 5-10 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Mucosal congestion, Acoustic rhinometry, Physiology