Heterotopic Ossification in Abdominal Incision and Pancreatic Cancer

Study Overview
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Brief Summary
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To investigate whether pancreatic cancer is the cause of heterotopic ossification of abdominal incision.

Detailed Description
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Heterotopic ossification of abdominal incision (HOAI) has long been regarded as a rare complication after general surgery. However,according to our retrospective analysis. HOAI was more frequently observed in the malignancy group (33/121 cases, 27.3%) than in the non- malignancy group. Because of the many biases in the retrospective analysis, the result was not widely shared. The purpose of this prospective study is to confirm that pancreatic cancer is the cause of heterotopic ossification of abdominal incisions. According to postoperative pathology, the patients were divided into two groups: pancreatic cancer group and benign diseases group.The researchers will observe whether patients develop heterotopic ossification of the abdominal incision one year after surgery to conclude.

Official Title
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The Causes of Heterotopic Ossification in Abdominal Incision After Pancreatic Surgery：A Single-center Prospective Study

Conditions
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Cancer of Pancreas, Ossification, Heterotopic

Intervention / Treatment
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* Diagnostic Test: Bone alkaline phosphatase
* Radiation: Abdominal CT scan


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Obtain informed consent from the patients. The patient's abdominal incision was double-closed with continuous suture of linea alba and fascia with absorbable suture, and skin was sutured with skin staples. Exclusion Criteria: Refusing to join the study Previous history of malignant tumor Previous history of midabdominal incision Abnormal calcium and phosphorus metabolism Distant metastasis Palliative operation performing neoadjuvant chemotherapy

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| PDAC Group<br>Radical operations were performed through central abdominal incisions. The postoperative pathology was pancreatic ductal adenocarcinoma. | Diagnostic Test: Bone alkaline phosphatase<br>* Hematologic indicators reflecting ossification.<br>Radiation: Abdominal CT scan<br>* Observe whether HOAI occurs.<br>|
| Benign Group<br>The abdominal midline incision was performed and the postoperative pathology was benign. | Diagnostic Test: Bone alkaline phosphatase<br>* Hematologic indicators reflecting ossification.<br>Radiation: Abdominal CT scan<br>* Observe whether HOAI occurs.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of HOAI | HOAI is determined by CT, whose CT number is similar to that of the same spine. | 12 months | 
| Bone alkaline phosphatase | Preoperative tests were performed and every three months postoperatively | 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of distant metastasis and local recurrence | Patients with pancreatic cancer were divided into HOAI and non-HOAI groups to determine whether there were differences in the incidence of distant metastasis and local recurrence between the two groups. | 12 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cancer of Pancreas, Ossification, Heterotopic, Abdominal incision