Ultrasound Guidance for Embryo Transfer

Study Overview
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Brief Summary
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Randomized controlled study comparing the TVUS versus TAUS guidance during the procedure of embryo transfer.

Detailed Description
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The aim of this study was to Compare between transvaginal and transabdominal ultrasound guided embryo transfer as regarding clinical pregnancy rate, patient comfort, time required for embryo transfer and endometrial visualization at time of embryo transfer.

Official Title
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Transvaginal Versus Transabdominal Ultrasound Guided Embryo Transfer. Randomized Controlled Trial.

Conditions
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Infertility

Intervention / Treatment
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* Procedure: Transvaginal Ultrasound Guided ET
* Procedure: Transabdominal Ultrasound Guided ET


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All patients undergoing autologous ICSI and frozen embryo transfer (FET) cycles. Exclusion Criteria: Cases of sever ovarian hyperstimulation requiring embryo cryopreservation Gestational surrogate cycles Oocyte donation cycles Very poor responders Patients with inadequate visualization of the uterus by ultrasound. Very difficult mock embryo transfer.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 42 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Transvaginal Ultrasound Guided ET<br>Transvaginal ultrasound is used to guide ET | Procedure: Transvaginal Ultrasound Guided ET<br>* Use of TVUS to guide ET<br>* Other names: Transvaginal US guided ET;|
| Experimental: Transabdominal Ultrasound Guided ET<br>Transabdominal ultrasound is used to guide ET | Procedure: Transabdominal Ultrasound Guided ET<br>* Use of TAUS to guide ET<br>* Other names: Transabdominal US guided ET;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical pregnancy | A clinical pregnancy is a pregnancy that is confirmed by ultrasonic visualization of gestational sac or heartbeat. | 3 weeks after Embryo transfer | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time required for ET | Time in seconds required for ET | Time from when the catheter is handed to the transferring physician to the time it is returned to the transferring embryologist. | 
| Degree of cramping and pain | Degree of cramping and pain from 0 to 10 by visual analogue scale (VAS) where 0 is no pain and 10 unbearable pain. | During and immediately after ET | 
| Endometrial visualization at time of embryo transfer | Endometrial visualization at time of embryo transfer by ultrasound | During ET | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Embryo Transfer, ICSI, Transvaginal Ultrasound