Endometrial Biopsy in Infertile Patients

Study Overview
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Brief Summary
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When a woman becomes pregnant, the fertilized egg attaches itself to the lining of the uterus (endometrium). The endometrium is constantly changing throughout a woman's menstrual cycle in response to the female hormones estrogen and progesterone. The endometrium must have certain characteristics (be at a specific phase in its cycle) in order for the fertilized egg to successfully attach. Infertility may be caused by an out of phase endometrium (i.e., the endometrium doesn't have the right characteristics when the fertilized egg reaches it). The purpose of this study is to evaluate whether the endometrial biopsy is useful in predicting the potential for becoming pregnant and bearing a child.

Detailed Description
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This study will evaluate the utility of the endometrial biopsy as a tool for the routine evaluation of the luteal phase of women presenting for infertility evaluation. The study will establish whether the mid-luteal or late-luteal phase is the most appropriate time to perform an endometrial biopsy. The study will be conducted through the multi-center Reproductive Medicine Network. Women with a history of infertility will be age matched to fertile women (controls). Women will be randomized either to the mid-luteal phase (7 to 8 days post-ovulation) endometrial biopsy group or to the late-luteal phase (12 to 13 days post-ovulation) endometrial biopsy group. Endometrial specimens will be evaluated histologically by a blinded pathologist.

Official Title
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Utility of the Endometrial Biopsy in the Evaluation of the Luteal Phase

Conditions
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Infertility

Intervention / Treatment
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* Procedure: Endometrial biopsy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria for Fertile Patients (controls) No history of involuntary primary or secondary infertility Willingness to discontinue hormonal contraceptives for 1 month prior to and through the duration of the study At least 1 child delivered within 24 months prior to study entry Most recent pregnancy resulting in a live birth (no interim spontaneous abortions) Tubal ligation within 24 months of study entry is acceptable if all other criteria are met Inclusion Criteria for Infertile Patients History of primary or secondary infertility for a period of at least 12 months No hormonal treatments in the month preceding study entry No history of tubal ligation

Ages Eligible for Study
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Minimum Age: 25 Years
Maximum Age: 39 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Endometrial biopsy|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Endometrium, Luteal phase, Endometrial biopsy