Vascular Risk Factors in INPH-patients

Study Overview
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Brief Summary
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Idiopathic normal pressure hydrocephalus (INPH) is a treatable and a common disease of the elderly. The overall objective of this work is to describe cardio- and cerebrovascular risk factors and vascular disease in shunted INPH-patients compared to an age- and sex matched elderly population, as well as the impact of vascular risk factors and vascular co-morbidity on clinical symptoms and outcome of surgery in INPH-patients. The hypothesis is that INPH-patients have a higher level of vascular risk factors and subclinical organ damage than a normal elderly population, and that the higher the level of existing vascular risk factors, the more severe the symptoms of the hydrocephalic disease.

Official Title
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Vascular Risk Factors, Subclinical and Manifest Vascular Disease in Patients With Idiopathic Normal Pressure Hydrocephalus

Conditions
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Vascular Diseases, Hydrocephalus, Normal Pressure, Brain Diseases, Central Nervous System Diseases, Nervous System Diseases

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: INPH-patients who underwent surgery 2008-2010 and registered in the Swedish National Register of Hydrocephalus age <60 and >85 (only for controls) living in Umeå Exclusion Criteria: death a known mini mental state estimation <23 inability to communicate (because of severe stroke, aphasia, dementia) (only for controls) individuals with INPH who has not yet underwent surgery, or has not been chosen to undergo surgery.

Ages Eligible for Study
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Minimum Age: 60 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Shunted patients with INPH<br>Cases: Patients with normal pressure hydrocephalus who have underwent surgery. Controls: Sex- and age-matched community based controls. | |
| Populationbased elderly.<br>A group of populationbased elderly, matched according to age and sex to the patients with INPH. Vascular risk factors studied. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Differences in bloodpressure between INPH-patients and a sex- and agematched community based population | Enrollment of participants 2010-2012. First, all participants complete a questionnaire, second they go to their local health care center or nearby hospital for measurements and blood samples. The visit at the health care center/hospital is within a couple of months. Participants are not followed further (cross-sectional study). Analyses performed 2013-2014. First results approximately reported in the end of 2013. | More than two weeks, not longer than 6 months. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quality of Life in INPH-patients compared to a sex- and age-matched population. | Enrollment of participants 2010-2012. First, all participants complete a questionnaire, second they go to their local health care center or nearby hospital for measurements and blood samples. The visit at the health care center/hospital is within a couple of months. Participants are not followed further (cross-sectional study). Analyses performed 2013-2014. First results approximately reported in the end of 2013. | More than 2 weeks, not longer than 6 months. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Normal pressure hydrocephalus, Vascular risk factors