Perfusion and Hypoxia Evaluation in Tumors Using 18F-FDG PET/CT

Study Overview
=================
Brief Summary
-----------------
Investigators want to use 18F-FDG PET/CT imaging to reflect tumor perfusion and hypoxia.

Detailed Description
-----------------
Perfusion and hypoxia were independent prognositic parameters for tumor patients. Developing a method that can evaluate tumor perfusion and hypoxia noninvasively and conveniently was in urgent need. 18F-FDG PET/CT imaging could reflect tumor hypoxia in 60min balanced imaging was proved and accepted. Moreover, FDG could diffuse out of the vasculature and through cell membranes passively and rapidly due to its lipophilicity, its regional uptake at initial times is expected to reflect tumor perfusion. So, investigators want to use 18F-FDG PET/CT imaging to evaluate tumor perfusion and hypoxia simutaniously，in order to guide the clinical diagnosis and treatment.

Official Title
-----------------
Tumor Perfusion and Hypoxia Evaluation and Comparation in 18F-FDG PET/CT

Conditions
-----------------
Perfusion and Hypoxia

Intervention / Treatment
-----------------
* Diagnostic Test: 18F-FDG PET/CT initial-time imaging
* Diagnostic Test: 18F-FDG PET/CT balanced-time imaging


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 1.solid tumor proved by pathology(d>3.0cm); 2.age>18-year-old; 3. Karnofsky performance status >70; 4.sign the informed consent. Exclusion Criteria: 1.There are obvious metal implants near the tumor; 2.Can not lie still for 15 minutes. 3.Pregnancy.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 18F-FDG PET/CT initial-time imaging<br>PET/CT imaging was underwent 5min after 18F-FDG injection. | Diagnostic Test: 18F-FDG PET/CT initial-time imaging<br>* 18F-FDG intravenous bolus injection after a fasting perid of more than 6 hours, simultaneously,PET/CT imaging using one bed lasting 5 minutes was underwent.<br>|
| 18F-FDG PET/CT balanced-time imaging<br>PET/CT imaging was underwent 60min after 18F-FDG injection. | Diagnostic Test: 18F-FDG PET/CT balanced-time imaging<br>* 18F-FDG intravenous injection after a fasting perid of more than 6 hours. After 60 minutes, PET/CT imaging using 6-7 bed positions each lasting 2 minutes was underwent.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation of the distribution of FDG between initial-time and balanced-time PET/CT | Initial-time and balanced-time PET/CT imaging were registrated using PET/CT Compare software in GE AW4.6 workstation. FDG distribution was evaluated in each imaging and the correlation was evaluated. | 2018.1 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| SUVs in initial-time and balanced-time PET/CT | the SUVmax and SUVmean was calculated in well-perfused area and hypoxia area in tumors using PET/CT Render software in GE AW4.6 workstation. | 2018.1 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
FDG, perfusion, hypoxia, tumor, PET