Stochastic Resonance Stimulation in Brain Plasticity and Post Stroke Motor Recovery

Study Overview
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Brief Summary
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This study evaluates the effectiveness of stochastic resonance electric stimulation on neuromuscular control and proprioception in healthy and individuals with stroke.

Detailed Description
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Stroke is one of the leading causes of motor disability. The main intervention strategy in stroke rehabilitation is to induce cortical plasticity for motor re-learning. It has been demonstrated that electrical stimulation applied to the periphery can elicit abundant sensory afferent inputs to enhance excitability and activation area in the sensorimotor cortex. Recent evidence suggested that a new type of electrical stimulation pattern, stochastic resonance stimulation, is capable of efficiently enhancing the activation of peripheral and central nervous system. Therefore, the purpose of this study are to identify the effects of stochastic resonance electrical stimulation on neuromuscular control and proprioception, and to investigate the effectiveness of combining stochastic resonance electrical stimulation with rehabilitation program on post stroke motor function recovery.

Official Title
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Effects of Stochastic Resonance Electrical Stimulation on Post Stroke Cortical Plasticity and Motor Function Recovery

Conditions
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Stroke, Ischemic, Healthy

Intervention / Treatment
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* Other: stochastic resonance electrical stimulation


Participation Criteria
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Eligibility Criteria
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In first stage Inclusion Criteria: healthy adults without history of neurological disorders or limitation in range of motion for thumb ﬂexion In the second stage Inclusion Criteria: first-ever cerebral cortical region involved chronic stroke, onset over a month able to perform active grasp on the affected side with the scores of manual muscle test at least two points at stable medical condition for intervention confirmed by a specialized physician. The exclusion criteria were history of other neurological disorders cognitive impairment (Mini-Mental State Examination score < 24, MMSE)29 unable to follow instructions contraindications of ES under 20 years old.

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: stochastic resonance<br>stochastic resonance electrical stimulation is applied to the upper extremity during the subjects perform upper extremity motor function. | Other: stochastic resonance electrical stimulation<br>* stochastic resonance electrical stimulation is applied in the upper extremity during motor functional training. Sham comparator group uses sham stimulation - same electrode location, but no electrical current is applied during motor functional training<br>|
| Sham Comparator: sham stimulation<br>sham electrical stimulation (same electrode location, but no electrical current is applied) is applied to the upper extremity during the subjects perform upper extremity motor function. | Other: stochastic resonance electrical stimulation<br>* stochastic resonance electrical stimulation is applied in the upper extremity during motor functional training. Sham comparator group uses sham stimulation - same electrode location, but no electrical current is applied during motor functional training<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| EEG | we will calculate power spectral and see whether change in the alpha, beta, theta band | baseline and one minute after stimulation | 
| Fugl-Meyer Assessment for Upper Extremity | changes in upper extremity function of the stroke subjects | baseline and one minute after stimulation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| force deviation | we first calculated the absolute value of the difference between force output and the value of 50%MVC for each data point and then calculated the average force deviation value by dividing the sum of all values by the number of data points | baseline and one minute after stimulation | 
| joint angle | ABS(the subject perform degree - target degree ) | baseline and one minute after stimulation | 
| muscle activation | EMG changes in stimulation | baseline and one minute after stimulation | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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stochastic resonance, proprioception, motor control, motor recovery