Influence of Periodontitis and Coronary Heart Disease on Galectin-3

Study Overview
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Brief Summary
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The aim of this study was to analyze the association between serum and salivary Galectin-3 levels in patients with periodontitis. Furthermore, the objective was to determine if the periodontitis influenced serum and salivary Galectin-3 levels

Detailed Description
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Healthy controls (n=38), patients with CHD (n=39), periodontitis (n=40), and a combination of periodontitis + CHD (n=38) were enrolled in the present study. The analyzed sample undergo a demographical, clinical and periodontal evaluation and serological analyses including Endothelin-1 (ET-1) and for serum and salivary Galectin-3 levels.

Official Title
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Influence of Periodontitis and Coronary Heart Disease on Galectin-3 in Serum and Saliva

Conditions
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Periodontal Diseases

Intervention / Treatment
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* Other: Observation of serum and salivary Galectin-3 levels


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Presence of at least 16 teeth CP with a minimum of 40% of sites with a clinical attachment level (CAL) ≥2mm and probing depth (PD) ≥4mm; Presence of at least ≥2 mm of crestal alveolar bone loss verified on digital periapical radiographs Presence of ≥40% sites with bleeding on probing (BOP) Exclusion Criteria: Intake of contraceptives Intake of immunosuppressive or anti-inflammatory drugs throughout the last three months prior to the study Status of pregnancy or lactation Previous history of excessive drinking Allergy to local anaesthetic Intake of drugs that may potentially determine gingival hyperplasia such as Hydantoin, Nifedipine, Cyclosporin A or similar drugs.

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Control<br>Observation of salivary Galectin-3 levels and correlation of salivary Galectin -3 evels with periodontal disease | Other: Observation of serum and salivary Galectin-3 levels<br>* Observation of serum and salivary Galectin-3 levels and correlation with periodontal indices<br>|
| Periodontitis<br>Observation of salivary Galectin-3 levels and correlation of salivary Galectin -3 evels with periodontal disease | Other: Observation of serum and salivary Galectin-3 levels<br>* Observation of serum and salivary Galectin-3 levels and correlation with periodontal indices<br>|
| Coronary heart disease<br>Observation of salivary Galectin-3 levels and correlation of salivary Galectin -3 evels with periodontal disease | Other: Observation of serum and salivary Galectin-3 levels<br>* Observation of serum and salivary Galectin-3 levels and correlation with periodontal indices<br>|
| Coronary heart disease + periodontitis<br>Observation of salivary Galectin-3 levels and correlation of salivary Galectin -3 evels with periodontal disease | Other: Observation of serum and salivary Galectin-3 levels<br>* Observation of serum and salivary Galectin-3 levels and correlation with periodontal indices<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes of Clinical Attachment Level (mm) | Measurment of changes in Clinical Attachment Level | 1-year |