Atopy Patch Test in Children With Food Allergy-related Gastrointestinal Symptoms

Study Overview
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Brief Summary
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Positive reactions in Atopy patch test in children with food allergy-related gastrointestinal symptoms

Detailed Description
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The prevalence of food allergy seems to be increasing, which might explain the increased demand for reliable evaluation of patients with suspected food-related gastrointestinal symptoms. Little is known about the diagnostic accuracy of atopy patch tests(APT) in the clinical practice. APT seems to have a better specificity than the IgE methods and seems to reflect late-phase clinical reactions.The aims of this study were to evaluate: (i) The prevalence of positive reaction of APTs for food allergy-related gastrointestinal diseases. (ii)Positive reaction of APT compare with skin prick test. (iii)Positive reaction of APT using lyophilized food vs commercially available food extracts. (iv)Side effect or adverse events of APT

Official Title
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Prevalence of Positive Reactions in Atopy Patch Test in Children With Food Allergy-related Gastrointestinal Symptoms

Conditions
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Food Allergy

Intervention / Treatment
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* Device: Atopy patch test with food allergen


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients who had history of suspected food allergy-related gastrointestinal symptoms eg. nausea and vomiting, diarrhea, abdominal pain or hematochezia after ingesting some food. Age 1 month-18 yrs Elimination diet was done at least 7 days before starting the study Written informed consent was obtained from the parents of each child enrolled in the study Exclusion Criteria: Who have dermographism Who have chronic disease eg. autoimmune disease, immune deficiency, cancer or allergic disease Pregnant women Who have severe eczema Who receive antihistamine, topical steroid and systemic steroid > 20 mg/day withiin 7 days prior study

Ages Eligible for Study
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Minimum Age: 1 Month
Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Atopy patch test<br>Atopy patches were applied on food allergy patient's back for 48 hrs then the patches were removed. Reaction was evaluated at 48 and 72 hrs after applying atopy patch test | Device: Atopy patch test with food allergen<br>* Atopy patches used with food lyophilized allergen and commercial allergen were placed on back of subjects for 48 hrs then atopy patches were taken off. Subjects should return to evaluate the reaction one day later (72 hr after applying atopy patch test)<br>* Other names: Fin chamber;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prevalence of positive reaction in APT in children with food allergy-related gastrointestinal symptoms | To evaluate (i) The prevalence of positive reaction of APTs for food allergy-related gastrointestinal diseases. (ii)Positive reaction of APT compare with skin prick test. | 3 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparisons atopy patch test reaction between lyophilized allergen and commercial allergen | To evaluate (iii)Positive reaction of APT using lyophilized food vs commercially available food extracts. (iv)Side effect or adverse events of APT | 3 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Atopy patch test