Fast Track Laparoscopic Surgery: A Better Option for Treating Colorectal Cancer Than Conventional Laparoscopic Surgery

Study Overview
=================
Brief Summary
-----------------
To compare the outcomes of fast track laparoscopic surgery and conventional laparoscopic surgery.

Detailed Description
-----------------
Method: This study is a blinded randomized trial. 70 patients with colorectal cancer will undergo laparoscopic colorectal resection, and will be divided into two groups. Protocols for fast-track group includes skipping preoperative mechanical bowel preparation, early restoration of diet and early postoperative ambulation. Outcome measures, length of hospital stay, postoperative surgical stress response (C reactive protein) and postoperative complications will be compared between the two groups.

Official Title
-----------------
Fast Track Laparoscopic Surgery: A Better Option for Treating Colorectal Cancer Than Conventional Laparoscopic Surgery

Conditions
-----------------
Colorectal Cancer

Intervention / Treatment
-----------------
* Procedure: fast-track surgery
* Other: conventional postoperative surgery


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age ≤75 years Good nutrition no systemic infection Elective laparoscopic surgery Exclusion Criteria: Age >75 years Malnutrition or an organ system infection Associated with obstruction, bleeding, emergency surgery or surgical intervention Tumor with extensive metastasis Before operation patient was fasting, underwent gastrointestinal decompression and received nutritional support Previous history of abdominal surgery Patient had previously undergone gastrostomy

Ages Eligible for Study
-----------------
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: fast-track surgery<br>Patients with colorectal cancer will undergo laparoscopic colorectal resection, and will be divided into two groups. Protocols for fast-track group includes skipping preoperative mechanical bowel preparation, early restoration of diet and early postoperative ambulation. | Procedure: fast-track surgery<br>* Patients with colorectal cancer will undergo laparoscopic colorectal resection, and will be divided into two groups. Protocols for fast-track group includes skipping preoperative mechanical bowel preparation, early restoration of diet and early postoperative ambulation.<br>|
| Other: convontional postoperative care<br>Patients with colorectal cancer will undergo laparoscopic colorectal resection, and will be divided into two groups. Protocols for fast-track group includes skipping preoperative mechanical bowel preparation, early restoration of diet and early postoperative ambulation. | Other: conventional postoperative surgery<br>* Patients with colorectal cancer will undergo laparoscopic colorectal resection, and will be divided into two groups. Protocols for fast-track group includes skipping preoperative mechanical bowel preparation, early restoration of diet and early postoperative ambulation.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Length of hospital stay |  | with the first 30 days(plus or minus 3days) after surgery | 
| Postoperative days |  | with the first 30 days(plus or minus 3days) after surgery | 
| First flatus time |  | with the first 30 days(plus or minus 3days) after surgery | 
| First defecation time |  | with the first 30 days(plus or minus 3days) after surgery | 
| solid diet time |  | with the first 30 days(plus or minus 3days) after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Analgesics |  | with the first 30 days(plus or minus 3days) after surgery | 
| CRP (mg/L) |  | with the first 30 days(plus or minus 3days) after surgery | 
| Complications:anastomotic leakage,intestinal obstruction,wound infection |  | one year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Fast track surgery, Laparoscopic surgery, colorectal cancer