Self-estimates and Objective Blood Alcohol Concentration in Emergency Department

Study Overview
=================
Brief Summary
-----------------
Many patients presenting in Emergency Department (ED) present alcohol acute intoxication. Some previous studies in general population found that young people under- or over-estimated of blood alcohol concentration (BAC). The hypothesis of the study is that self-estimation of BAC by the patient is under-estimated. Moreover, comparing self-estimation of BAC and objective measure of BAC, which is routinely performed in ED, could increase in patients the awareness of the disorders, increase motivation to change of the patient, and increase the rates of seeking-treatment six months after the first evaluation, in particular in patients with alcohol use disorders. To the investigators knowledge, there is no study investigating self-estimation, compared to objective measurement of blood alcohol concentration in patients with alcohol intoxication presenting to an Emergency Department (ED). The study will assess blood alcohol concentration and self-estimates of BAC, using the Subjective Effects of Alcohol Scale for Measuring Subjective Response to Alcohol in 100 patients with or without alcohol use disorders according to DSM-5 classification (using MINI scale and Alcohol Use Disorders Identification Test (AUDIT)

Official Title
-----------------
Self-estimates and Objective Measurement of Blood Alcohol Concentration in Patients With Alcohol Intoxication Presenting to an Emergency Department

Conditions
-----------------
Alcohol Use Disorder, Blood Alcohol Content

Intervention / Treatment
-----------------
* Biological: blood alcohol concentration withdrawal


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients admitted in Emergency Department while intoxicated will be included in the study, including patients with or without alcohol use disorders according to DSM-5 classification. aged 15-64 years old patients who will be orally informed and receive a written summary blood alcohol concentration of 60mg/dl or higher Patients not opposed to participating in the study, who have received an oral and written information Exclusion Criteria: Drug intoxication (cannabis, opiates, amphetamines, cocaine), psychotropic medication intoxication (benzodiazepines, antipsychotics), primary neurologic conditions, mental retardation, dementia, amnestic disorders, mental disorders due to a general, medical condition and substance-induced psychotic disorders.

Ages Eligible for Study
-----------------
Minimum Age: 15 Years
Maximum Age: 64 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: patients with alcohol use disorders<br> | Biological: blood alcohol concentration withdrawal<br>* The blood alcohol concentration is systematically performed in all intoxicated patients admitted in Emergency Department<br>|
| Experimental: patients without alcohol use disorders<br> | Biological: blood alcohol concentration withdrawal<br>* The blood alcohol concentration is systematically performed in all intoxicated patients admitted in Emergency Department<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mean change between real blood alcohol concentration and self-estimated blood alcohol concentration | Comparison of real blood alcohol concentration and self-estimated blood alcohol concentration | Day =0 (day of patient inclusion) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mean change between real blood alcohol concentration and self-estimated blood alcohol concentration in patient with alcohol use disorders | Comparison of real blood alcohol concentration and self-estimated blood alcohol concentration with alcohol use disorders according DSM-5 classification (Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) | Day =0 (day of patient inclusion) | 
| Mean change between real blood alcohol concentration and self-estimated blood alcohol concentration in patient without alcohol use disorders | Comparison of real blood alcohol concentration and self-estimated blood alcohol concentration without alcohol use disorders according DSM-5 classification (Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) | Day =0 (day of patient inclusion) | 
| Measure motivation to change during the first interview at the Emergency Department | Measure motivation to change during the first interview at the Emergency Department | Day =0 (day of patient inclusion) | 
| Measure motivation to change six months following the first interview at the Emergency Department | Measure motivation to change six months following the first interview at the Emergency Department | six months following the first interview at the Emergency Department | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
blood alcohol concentration, Emergency Department, Alcohol use disorders