COPD in Obese Patients

Study Overview
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Brief Summary
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The study included 176 patients with COPD. The first group included 88 normal weight patients with COPD: 71 men and 17 women, mean age 62.40 ± 8.83 years. The second group included 88 patients with COPD and obesity: 64 men and 24 women, mean age 62.94 ± 5.96 years. We assessed the frequency of COPD exacerbations in last 12 months, the severity of symptoms such as dyspnea, sputum production, fatigue. Spirometry, six-minute walk test and analysis of body tissue type composition were performed. BODE index was calculated. Levels of leptin, adiponectin, interleukins-4,6,8,10, interferon-γ, c-reactive protein (CRP), tumor necrosis factor receptor 1 (TNF-R1), tumor necrosis factor receptor 2 (TNF-R2), tumor necrosis factor alpha (TNF-α) were measured in blood serum.

Official Title
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Features of Chronic Obstructive Pulmonary Disease Clinical Course in Obese Patients

Conditions
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Copd, Obese, Obesity, Abdominal

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: COPD diagnosis, informed consent for voluntary participation in the study Exclusion Criteria: patient participation in any interventional study, COPD exacerbation, concomitant lung diseases, such as confirmed or suspected malignant lung disease or other respiratory disease, such as interstitial pulmonary fibrosis, tuberculosis, sarcoidosis, bronchial asthma, bronchiectasis, concomitant diseases of other organs and systems, such as acute cardiovascular diseases, chronic kidney diseases and liver failure.

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with COPD and obesity<br>Patients consented to have a blood sample taken | |
| Normal body weight patients with COPD<br>Patients consented to have a blood sample taken | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Simptoms | dyspnea, sputum production and fatigue | 1 year | 
| Labotary tests | Levels of interleukins-4,6,8,10, interferon-γ, tumor necrosis factor receptor 1 (TNF-R1), tumor necrosis factor receptor 2 (TNF-R2), tumor necrosis factor alpha (TNF-α) were measured in blood serum (pg / ml) | 1 year | 
| Spirometry | FEV1, % pred,FVC, % pred.,FEV1/FVC, % | 1 year | 
| Labotary tests | Levels of leptin (ng / ml) measured in blood serum | 1 year | 
| Labotary tests | Levels of adiponectin (µg / ml) measured in blood serum | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Symptroms and laboratory correlations | Statistical methods allowing to figure out associations and correlations between blood tests and symptoms | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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spirometry, inflammation, copd