Building Research Initiative Group: Chronic Illness Management and Adherence in Transplantation

Study Overview
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Brief Summary
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Over the past decades, survival rates in heart transplantation recipients improved significantly, due to advancements in regimens of immunosuppressives and surgical techniques, but are still limited to the first 12 months post transplantation. Long-term survival remains almost unchanged indicating the need to identify and improve relevant factors. Evidence in other chronically-ill patient populations shows that the healthcare system (e.g. level of chronic illness management (CIM)) and patient self-management (e.g. adherence) drive improvements in outcomes. The BRIGHT study is the first multi-centre, multi-continental study examining healthcare system and heart transplant centres chronic illness management practice patterns and potential correlates of immunosuppressive medication nonadherence. The knowledge gained will inform clinicians, researchers and healthcare policy makers about the level(s) interventions need to be implemented at to improve long-term outcomes for transplant recipients.

Detailed Description
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Background: After receiving a heart transplant (HTx) patients have to adhere to a number of health behaviors (e.g., medication taking, and smoking cessation) in order to guarantee optimal outcomes. Non-adherence to these health behaviors is associated with poor clinical and economic outcomes. However, the prevalence of non-adherence to these health behaviors is high among HTx recipients. Furthermore, differences in prevalences among countries and continents are observed. The extent to which a HTx recipient is adherent is affected by a variety of risk factors, namely 1) patient-related factors, 2) socioeconomic factors, 3) therapy-related factors, 4) health-related factors and 5) healthcare system and team factors. To-date, this last group of factors only received limited attention in understanding the complex phenomena of adherence. Aims: The aims of this study are: To describe CIM practice patterns among centres, countries/continents in HTx. To assess the prevalence and variability of nonadherence to treatment regimen, i.e. medication taking, smoking cessation, diet keeping, alcohol consumption, physical activity, sun protection and appointment keeping in HTx recipients among centres, countries/continents. To determine which multi-level factors are related to immunosuppressive medication adherence at the different system levels To benchmark the participating centres, countries and continents in relation to CIM practice patterns and non-adherence to health behaviours Methodology: The BRIGHT study is an international, multi-center, cross-sectional study. Data were collected using interviews and questionnaires. HTx recipients, nurses working in the post-transplantation care of HTx recipients and the medical directors of the HTx programs were surveyed. The investigators recruited a convenience sample of 36 heart transplantation centers (North America (n= 12), European (n= 19), Australia (n= 2) and South America (n= 3)). Within participating centers, a random sample of patients who met the study eligibility criteria was selected. Per center, a minimum of 20 and a maximum of 60 patients were included. In total, 1677 heart transplant recipients were invited to participate in this study. The questionnaires used in this study will be existing questionnaires (e.g. BAASIS interview to assess adherence with medications, DASS to assess depression) as well as questionnaires developed for this study. During a regular follow-up visit, patients were invited by a staff person to participate in this study. The staff first informed the patient about the study and, if the patient was willing to participate, retrieved a signed informed consent. Participating in this study was voluntary. Informed consent of the nurses and the medical director of the transplant center were implied by completing the questionnaires. Participant names will be held in strict confidence and will remain anonymous in research reports or publications. The results of the benchmarking of the parameters assessed in this study will be reported by figures and tables. Because of privacy, the HTx centers can only identify the parameters specific to their center. All other information will be reported anonymously.

Official Title
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Building Research Initiative Group: Chronic Illness Management and Adherence in Transplantation

Conditions
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Heart Transplantation

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Heart transplant patients 18 years or older at time of inclusion Transplanted and followed-up for routine care in a participating transplant center First transplant Single-organ transplant Between 1 and 5 years post-transplant Ability to read, understand and sign written informed consent (in Dutch, English, French, German, Spanish, Italian, or Portuguese, depending on the languages spoken within the country where the participating transplant center is located) Provided written informed consent Exclusion Criteria: Receiving professional support in medication taking Involved in adherence-intervention research or drug trials during the past 6 months

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Self-reported non-adherence to immunosuppressive medication | Participants will be asked about immunosuppressive medication taking during the prior 4 weeks | Once | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Self-reported non-adherence to other medications (excl. immunosuppressive medications) | Participants will be asked about adherence to other medications (excl. immunosuppressive medications) during the prior 4 weeks | Once | 
| Self-reported adherence to smoking cessation | Participants will be asked about current and past smoking | Once | 
| Self-reported adherence to dietary modifications | Participants will be asked about adherence to dietary recommendations during the past year | once | 
| Self-reported alcohol use | Participants are asked about alcohol intake during the past year | Once | 
| Self-reported adherence to physical activity | Participants are asked about their level of physical activity during the past week | Once | 
| Self-reported adherence to sun protection | Participants will be asked about the routine use of sun protection measures | Once | 
| Self-reported adherence to appointment keeping | Participants will be asked if they kept the last five appointments with the transplant team | Once | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Heart transplantation, Medication adherence, Behavior system factor