Study on the Efficacy of Vetiver Essential Oil Aroma on Depression/Anxiety People

Study Overview
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Brief Summary
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In this study, subjects with depression/anxiety inhaled the essential oil, which contained sedative, soothing, and relaxing active ingredients to stimulate the olfactory nerve. The essential oil further transmitted to the limbic system that controls emotions in the brain, and then affected the human's mood. The natural aroma can not only awaken the limbic system's memory of aroma but also reflect the subconscious area of the brain, with physiological changes (such as controlling blood pressure, breathing, heartbeat, stress changes, memory, and hormonal coordination.) This study monitors the subject's autonomic nerve parameters before and after aromatherapy to obtain the olfactory cerebral nervous system to convey the message. When the study finishes, we expected to help the subject to relax and soothe the mind.

Detailed Description
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Subjects receive three times 30 mins aromatherapy of Limon or Vetiver essential oil per time for the month. Anthropometric measurements such as blood pressure (systolic blood pressure [SBP] and diastolic blood pressure [DBP]), autonomic nerve parameters including a. SDNN (standard deviation of all normal to normal intervals index); b. HRV（heart rate variability）; c. LF（0.04-0.15 Hz）and HF（0.15-0.4 Hz）were measured every week. PSQI（Pittsburgh sleep quality index）and HADS (Hospital Anxiety and Depression Scale) were measured initial and ten ends.

Official Title
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Study on the Efficacy of Vetiver Essential Oil Aroma on Depression/Anxiety People

Conditions
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Anxiety Depression Disorder

Intervention / Treatment
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* Device: Limon essential oil aromatherapy
* Device: Vetiver essential oil aromatherapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Depressed/anxious people (diagnosed as a single episode of major depression, recurrence of major depression, mild depression, panic disorder, and anxiety.) Those diagnosed with symptoms of depression, and anxiety related to stress adjustment disorder, and willing to cooperate with the study. Age 20-65 years old Exclusion Criteria: an alcoholic Uncontrolled diabetes Those who have had a stroke in the last year Pregnant and lactating women People with liver or heart disease Arrhythmia or those with a heart rhythm regulator Those whose heart has already been fitted with a cardiac catheter stent Those who have used central nervous system stimulants (regardless of the length of time) Those who are allergic to essential oils Those who have used aromatherapy within a month Subjects request to withdraw from the trial The host feels unsuitable to continue the study

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Placebo<br>Subjects take 30 mins aromatherapy of Limon essential oil per time, a total of 3 times for the month. | Device: Limon essential oil aromatherapy<br>* Subjects receive three times 30 mins aromatherapy of Limon essential oil per time for the month. Anthropometric measurements such as blood pressure (systolic blood pressure [SBP] and diastolic blood pressure [DBP]), autonomic nerve parameters including a. SDNN (standard deviation of all normal to normal intervals index); b. HRV（heart rate variability）; c. LF（0.04-0.15 Hz）and HF（0.15-0.4 Hz）were measured every week. PSQI（Pittsburgh sleep quality index）and HADS (Hospital Anxiety and Depression Scale) were measured initial and ten ends.<br>|
| Experimental: Experimental<br>Subjects take 30 mins aromatherapy of vetiver essential oil per time, a total of 3 times for the month. | Device: Vetiver essential oil aromatherapy<br>* Subjects receive three times 30 mins aromatherapy of vetiver essential oil per time for the month. Anthropometric measurements such as blood pressure (systolic blood pressure [SBP] and diastolic blood pressure [DBP]), autonomic nerve parameters including a. SDNN (standard deviation of all normal to normal intervals index); b. HRV（heart rate variability）; c. LF（0.04-0.15 Hz）and HF（0.15-0.4 Hz）were measured every week. PSQI（Pittsburgh sleep quality index）and HADS (Hospital Anxiety and Depression Scale) were measured initial and ten ends.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The aromatherapy measure autonomic nerve parameter SDNN (standard deviation of all normal to normal intervals index) |  | one month | 
| The measure blood pressure (SBP and DBP) | values change of systolic and diastolic BPs | one month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Vetiver oil, Aromatherapy, Anxiety, Depression