Does Coffee Intake Reduce Postoperative Ileus After Elective Colorectal Surgery

Study Overview
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Brief Summary
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The aim of the study is to investigate if postoperative coffee intake decreases the time until first bowel movement in elective colorectal surgery with primary anastomosis.

Detailed Description
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Postoperative ileus after colorectal surgery is a frequent problem which significantly prolongs hospital stay and increases perioperative costs. Postoperative therapeutic interventions vary significantly between different hospitals due to missing evidence-based guidelines. Coffee is a safe, cheap and simple agent without significant side effects which can positively influence the bowel function. The aim of the investigators is to evaluate in an own study if coffee consumption has an influence on the duration of postoperative ileus. The present trial is designed to evaluate if postoperative coffee intake decreases the time until first bowel movement in colorectal surgery with primary anastomosis. This study would be the second study which evaluates the described questions under randomized conditions.

Official Title
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Does Coffee Intake Reduce Postoperative Ileus After Elective Colorectal Surgery - a Prospective, Randomized Controlled Study - the COFFEE STUDY

Conditions
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Postoperative Ileus

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients scheduled for elective laparoscopic or open colorectal surgery due to benign or malignant colorectal disease, which need a large bowel resection with primary anastomosis Age equal or greater than 18 years Patients that are able to give informed consent Elective Surgery Anastomosis above 6 cm from anal verge Exclusion Criteria: Participation in other studies Additional small bowel anastomosis Need for extended adhesiolysis Need for a stoma (e.g. protective ileostomy) Emergency operation with diffuse peritonitis or preexisting ileus Preoperative radiation Known hypersensitivity or allergy to coffee Expected lack of compliance Impaired mental state or language problems

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Arm A<br>Arm A (treatment arm: coffee): patients after colorectal surgery receive coffee in addition to the regular infusion therapy and/or alimentation | |
| Arm B<br>Arm B (control arm: water / tea): patients after colorectal surgery receive water or tea (excluding black tea) and no coffee until the first bowel movement in addition to the regular infusion therapy and/or alimentation | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time to first bowel movement | Time to first bowel movement (time from the end of surgery until the first passage of stool recorded by nursing staff) as a marker for the termination of postoperative ileus. | Follow-up per patient: 1 month postoperatively | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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postoperative ileus, coffee, colorectal surgery