Detection of Staph Colonization in Pre-op Arthroplasty Patients

Study Overview
=================
Brief Summary
-----------------
This study will evaluate which body site(s) provide the best source of possible staph presence in participants undergoing total joint arthroplasty. If the pre-operative cultures indicate staph presence, an Infectious Disease specialist will be consulted for standard of medical care consultation and treatment management. Participants will be followed for 2 years post-implantation of prosthetic joint to monitor development of prosthetic joint infection.

Detailed Description
-----------------
The presence of Staph in/on a patient who will undergo total joint replacement is a risk in that the patient could go on to develop infection at the surgery site after surgery. The purpose of this study is to evaluate if it is beneficial to to administer a questionnaire and obtain cultures from various body sites from patients prior to surgery and also to determine which body site(s) provide the best source of possible staph presence. If the pre operative cultures indicate staph is present, an Infectious Disease specialist will be consulted for standard of medical care consultation and treatment management. All patients scheduled to have total joint arthroplasty are eligible to participate. The research team will follow the study patients for 2 years after they undergo prosthetic joint implantation to monitor for development of prosthetic joint infection.

Official Title
-----------------
Enhanced Detection of Staphylococcus Aureus Colonization in Patients Undergoing Prosthetic Joint Implantation.

Conditions
-----------------
Surgical Site Infection

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All adult patients undergoing prosthetic joint implantation Exclusion Criteria: None

Ages Eligible for Study
-----------------
Minimum Age: 19 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Pre-op THA and TKA patients<br>Patients who are scheduled for total joint arthroplasty | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Development of surgical site infection. | The patient will be assessed by phone every 6 months for 2 years for development of infection at the surgical site. | Change in surgical site from baseline at 6 months, 1 year, 18 months and 2 years. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Anatomical site(s) which are best utilized for swab cultures to detect S aureus. | We hope to determine which anatomical site(s) are best utilized for swab cultures to detect S aureus colonization in patients undergoing prosthetic joint replacement. We will collect data on infection development for up to 2 years post operatively. | Up to 24 months post operatively. | 
| Post operative infection (s.aureus) development. | We will measure at what percentage a pre-operative questionnaire accurately predicts if a patient will develop an infection (s.aureus) between day one and 2 years post operatively. | Up to 24 months post operation. | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
staphylococcus aureus, prosthetic joint implantation