linjc16/ctgov huggingface dataset:
Exploring Clinical Trial Experiences of People With Leiomyosarcoma

Study Overview
=================
Brief Summary
-----------------
Clinical study participation has historically been heavily biased toward specific demographics. Several people will be invited to enroll in this study so that it may collect a variety of data about leiomyosarcoma clinical trial experiences and identify barriers to participation as well as the causes of participants' failure or withdrawal. People with leiomyosarcoma who are invited to take part in medical research will benefit from the analysis of the data.

Official Title
-----------------
An In Depth Study Investigating The Experiences of Patients In Leiomyosarcoma Clinical Trials

Conditions
-----------------
Leiomyosarcoma

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patient has self-identified as planning to enroll in an interventional clinical trial Patient has been diagnosed with leiomyosarcoma Patient is a minimum of 18 years or older Exclusion Criteria: Patient does not understand, sign, and return consent form Inability to perform regular electronic reporting Patient is pregnant ECOG score of 4

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patients who decide to enroll in an leiomyosarcoma clinical trial |  | 3 months | 
| Rate of patients who remain in leiomyosarcoma clinical trial to trial completion |  | 12 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
leiomyosarcoma
Preferences of Vaccination for COVID-19 Among University Students and Staff: A Discrete Choice Experiment

Study Overview
=================
Brief Summary
-----------------
From March 2021, COVID-19 vaccines have been made available to Hong Kong residents, first to priority groups including healthcare professionals and the elderly, and later to all adults and adolescents. Vaccinated individuals are generally exempted from mandatory regular out-of-pocket antigen testing. Vaccinated individuals of university halls and colleges of The University of Hong Kong (HKU) will also be exempted from mandatory weekly antigen testing. Freedom of choice is highly respected in the HKU community and as such, we would like to better understand the decision-making process among members of the HKU community. The anonymised results of this independent research study will help us understand preferences among the HKU community and inform on future vaccination planning policies. Objectives: To elicit HKU staff and students' preferences and their willingness-to-pay (WTP) for COVID-19 vaccination in Hong Kong Design: An online cross-sectional internet-based questionnaire with a discrete choice experiment (DCE) design distributed via email. All current students and staff from the University of Hong Kong are eligible to participate in the study Main outcome measures: Preferences for the efficacy of protecting against infection, against severe disease manifestations, duration of protection, risk of adverse events, incentives, and out-of-pocket costs

Official Title
-----------------
Preferences of Vaccination for COVID-19 Among University Students and Staff: A Discrete Choice Experiment

Conditions
-----------------
Preference, Patient

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: At least 18 years old Fluent in English Students and staff of The University of Hong Kong Exclusion Criteria: Individuals who are younger than 18 years old Individuals who are unwilling to give consent

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Preferences for efficacy of protection against infection |  | At baseline | 
| Preferences for efficacy of protection against severe disease manifestations |  | At baseline | 
| Preferences for duration of protection |  | At baseline | 
| Preferences for risk of adverse events |  | At baseline | 
| Preferences for incentives |  | At baseline | 
| Preferences for out-of-pocket cost |  | At baseline |
Effect of Periodontal Treatment on Salivary Biomarkers

Study Overview
=================
Brief Summary
-----------------
The investigators plan to recruit 40 healthy patients referred to the unit of Periodontology, diagnosed with generalized moderate - severe chronic periodontitis. treatment will include 4 - 6 sessions of scaling + root planning, oral hygiene instructions and motivation. Whole saliva will be collected at intake and 8 - 14 weeks post periodontal treatment. Saliva will be analyzed for trans locator protein. Study hypothesis: Periodontal treatment has an affect on saliva components.

Official Title
-----------------
Effect of Periodontal Treatment on Salivary Biomarkers.

Conditions
-----------------
Chronic Periodontitis

Intervention / Treatment
-----------------
* Procedure: periodontal treatment - scaling and root planning


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: healthy patients moderate - sever chronic periodontitis Exclusion Criteria: systemic disease pregnancy subjects under the age of 18

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: periodontal treatmnent<br> | Procedure: periodontal treatment - scaling and root planning<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Whole saliva & translocator protein (TSPO) | Change in whole saliva & translocator protein (TSPO) post periodontal treatment | Intake of patients than 8 - 12 weeks after periodontal treatment (scaling & root planning) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Periodontal measurements (periodontal pocket depth, bleeding on probing & clinical attachment level) | periodontal probing depth, bleeding on probing and clinical attachment level. | Intake 8 - 12 weeks post periodontal treatment (scaling & root planning) |
O-arm Assessment of Vertebral Movement Using ST2R Technique

Study Overview
=================
Brief Summary
-----------------
The study is quantifying how the patients' back has been corrected using Medicrea's hardware through imaging taken before,during and after the surgery.

Detailed Description
-----------------
Visits include the pre-operative visit, 1 and 2 year follow-up visits. Participation includes answering questions and filling out questionnaires. There are no immediate benefits by joining this study, but could potentially help define better techniques for the future spine surgeries. The risks involved in this study are minimal and there are no alternatives to this study.

Official Title
-----------------
The O-arm Assessment of Vertebral Movement Pre and Post Correction Using ST2R Technique

Conditions
-----------------
Scoliosis; Adolescence

Intervention / Treatment
-----------------
* Device: Spinal Hardware


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adolescent idiopathic scoliosis requiring selective thoracic posterior spinal instrumentation and fusion with the PASS LP system (screws, rods, hooks) and UNiD rod technology Age between 10 and 21 Lenke Type 1 curve Consent and Assent to participate in the study Exclusion Criteria: Age superior to 21 years Spinal deformities other than Lenke 1 type Use of implant other than those from the PASS LP system or sublaminar bands Neuromuscular or degenerative scoliosis Spinal cord abnormalities with any neurologic symptoms or signs Spinal cord lesions requiring neurosurgical interventions, such as hydromyelia requiring Arnold Chiari decompression Primary muscle diseases (e.g. Charcot-Marie Tooth, Guillain-Barre syndrome, Cerebral palsy, or Spina bidifa, Neurofibroma) Primary abnormalities of bones (e.g. osteogenesis imperfect) Congenital Scoliosis Scoliosis requiring anterior release Previous spinal surgery Absence of required preoperative data (diagnosis, consent…)

Ages Eligible for Study
-----------------
Minimum Age: 10 Years
Maximum Age: 21 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Study Cohort<br> | Device: Spinal Hardware<br>* Pedicle screws and patient specific rods<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quantify vertebral derotation with ST2R technique in AIS for Lenke Type 1 patients |  | 4 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Assess 3 dimensional correction pre- and post- correction using x-rays and O-arm data |  | 4 years |
Epidemiologic Study to Assess the IGRA Positivity in Populations With a High TB Burden

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to conduct a multi-country, multi-site, epidemiologic study designed to assess the proportion of interferon gamma release assay (IGRA) positivity, at site level, and to build capacity to conduct a future TB vaccine efficacy study.

Official Title
-----------------
A Multi-country, Epidemiologic Study to Assess the Interferon Gamma Release Assay (IGRA) Positivity, and to Build Capacity to Conduct a Tuberculosis (TB) Vaccine Efficacy Study, in Populations With a High TB Disease Burden

Conditions
-----------------
Tuberculosis, Pulmonary

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Capable of giving signed informed consent and informed assent (as appropriate), which includes compliance with the requirements listed in the informed consent form (ICF) and informed assent form (IAF) Between 15 and 34 years of age (inclusive) Participants who agree to stay in contact with the study site for the duration of the study, provide updated contact information as necessary, and have no current plans to relocate from the study area for the duration of the study. Exclusion Criteria: History of active TB within the last 24 months (i.e., 24 months from end of treatment to day of screening, based on history [no documentation required]) History of previous administration of an experimental Mtb vaccine Unstable / uncontrolled chronic condition according to the judgment of the investigator -

Ages Eligible for Study
-----------------
Minimum Age: 15 Years
Maximum Age: 34 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| IGRA status | Proportion of participants with a positive IGRA, per site, calculated using protocol population. 95% CI will summarize the precision associated with the estimate | Screening | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| IGRA status | Proportion of participants with a positive IGRA, per site using per protocol population. 95% CI to summarize the precision associated with estimates. A logistic regression model will estimate the association age with probability of positive IGRA | Screening | 
| Suspected pulmonary TB during follow-up period | Incidence rate of participants with suspected TB to be summarized overall. Exact 95% CI to be provided | Day 1 up to 30 months | 
| Laboratory-confirmed pulmonary TB during follow-up period | Incidence rate of participants with suspected TB to be summarized overall. Exact 95% CI | Day 1 up to 30 months |
Inspiratory Muscle Training and Low Back Pain

Study Overview
=================
Brief Summary
-----------------
Proprioceptive weighting changes may explain differences in postural control performance. In addition, the respiratory movement has a disturbing effect on postural balance. Postural balance seems to be impaired in individuals with respiratory disorders. Besides the essential role of respiration, the diaphragm may also play an important role in the control of the trunk and postural balance. Deficits in proprioception are found in a subgroup of patients with low back pain. In addition, disorders of respiration have been identified as strongly related to low back pain. The aim of the study is to clarify whether inspiratory muscle training has a positive effect on proprioceptive postural control in individuals with recurrent low back pain.

Conditions
-----------------
Inspiratory Muscle Training, Low Back Pain, Respiratory Disorders

Intervention / Treatment
-----------------
* Other: Inspiratory muscle training
* Other: Sham inspiratory muscle training


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria individuals with low back pain: Age: 18-45 years old At least 1 year of low back pain with/without referred pain in buttock/thigh At least 3 episodes of disabling low back pain At least a score of 20% on the Oswestry Disability Index Willingness to sign the informed consent Exclusion Criteria: History of major trauma and/or major orthopedic surgery of the spine, the pelvis or the lower quadrant One of the following conditions: Parkinson, multiple sclerosis, stroke, history of vestibular disorder, respiratory disease, pregnancy Radicular symptoms Not Dutch-speaking Strong opioids Neck pain Smoking history

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Inspiratory muscle training<br> | Other: Inspiratory muscle training<br>* Three times daily inspiratory muscle training (2x30 breaths) at an intensity of 60% Pi,max<br>* Other names: Powerbreathe Classic;|
| Sham Comparator: Sham inspiratory muscle training<br> | Other: Sham inspiratory muscle training<br>* Three times daily inspiratory muscle training (2x30 breaths) at an intensity of 10% Pi,max<br>* Other names: Powerbreathe Classic;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Proprioceptive postural control | Center of pressure displacement (force plate) in standing in response to local muscle vibration on ankle and back muscles to specifically detect the role of proprioception in postural control. | 8 weeks |
Efficacy of Epidural Steroid for Controlling Pain After Primary TKA

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine efficacy of epidural steroid for postoperative pain control after TKA

Detailed Description
-----------------
Epidural triamsinolone can reduce postoperative pain and longer duration of pain control after TKA

Official Title
-----------------
Efficacy of Epidural Steroid in Controlling Postoperative Pain After Primary Total Knee Arthroplasty: A Randomized Double-blinded Controlled Trial

Conditions
-----------------
Postoperative Pain

Intervention / Treatment
-----------------
* Drug: epidural triamsinolone
* Drug: epidural lidocaine


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: osteoarthritis of the knee who undergoing unilateral primary total knee arthroplasty 50-85 years old ASA class 1-3 Exclusion Criteria: unable to perform epidural anaesthesia history of drug allergies: lidocaine, steroid renal impairment (CrCl <30 mL/min) liver impairment cognitive function disorders displacement of epidural catheter

Ages Eligible for Study
-----------------
Minimum Age: 50 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Epidural lidocaine<br>epidural lidocaine: 3 mL of 1% lidocaine with adrenaline and 3 mL of 1% lidocaine without adrenaline into epidural catheter at 48 hr after surgery | Drug: epidural lidocaine<br>* add into catheter at 48 hr after surgery<br>* Other names: epidural xylocaine;|
| Experimental: epidural triamsinolone<br>epidural triamsinolone: 40 mg of triamsinolone (1 mL), 2.5 mL of 1% lidocaine with adrenaline and 2.5 mL of 1% lidocaine without adrenaline into epidural catheter at 48 hr after surgery | Drug: epidural triamsinolone<br>* add drugs into catheter at 48 hr after surgery<br>* Other names: epidural steroid;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| post-operative pain | measured with VAS for pain (VAS at rest and on motion) | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| functional knee score | measured with WOMAC | 3 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
post-operative pain control, total knee arthroplasty, epidural steroid injection
Sex Differences in Oral Bacteria

Study Overview
=================
Brief Summary
-----------------
Females have a lower incidence of hypertensive and cardiovascular disorders that may relate to differences in nitrogen oxides in the blood and saliva. Some nitrogen oxides are recycled with the help of oral bacteria to nitric oxide which is protective against vascular disorders. This study will test the hypothesis that females have different numbers and species of these nitrogen-oxide reducing bacteria.

Official Title
-----------------
Investigation of the Sex Differences in Oral Microbiota and Their Effect on Circulating Nitrite Levels

Conditions
-----------------
Cardiovascular Disease

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy subjects aged 18-45 who have volunteered themselves and are willing to sign the consent form Exclusion Criteria: Healthy subjects unwilling to consent History of hypertension, diabetes or hypertensive on BP measurement Pregnant, or any possibility that a subject may be pregnant unless in the latter case a pregnancy test is performed with a negative result History of any serious illnesses, including recent infections or trauma Subjects taking systemic medication (other than the oral contraceptive pill) Subjects with self-reported use of mouthwash or tongue scrapes Subjects with recent or current antibiotic use (within 3 months) Subjects with a history, or recent treatment of (within last 3 months) of any oral condition (excluding caries), including gingivitis, periodontitis and halitosis

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Males<br> | |
| Females<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Bacterial species identification |  | At baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Bacterial count |  | At baseline | 
| Blood pressure |  | At baseline | 
| Nitrogen oxide levels in biological fluids |  | At baseline | 
| Oral nitrate reduction |  | At baseline |
Images in Extracranial Artery Stenosis

Study Overview
=================
Brief Summary
-----------------
The goals of this trial are: To compare the sensitivity and specificity of various tools including Doppler and magnetic resonance imaging (MRI) for diagnosing vertebral artery stenosis and carotid artery stenosis. The positron emission tomography (PET)/MRI fusion imaging will be a promising tool to provide both anatomical and functional imaging for vulnerable plaques. To identify patients at high risk of plaque rupture by image studies, biomedical profile, and gene expression of circulating monocytes.

Official Title
-----------------
The Differences in Images of Vertebral Artery Stenosis and Carotid Artery Stenosis Pre- and Post-Percutaneous Transluminal Angioplasty and the Gene Expression Patterns in Peripheral White Blood Cells

Conditions
-----------------
Extracranial Atherosclerosis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with symptomatic extracranial atherosclerosis who are going to receive angiography and possible intervention. Exclusion Criteria: Acute systemic illness Creatinine > 3 mg/dl Unable to tolerate the tests (including MRI and PET/computed tomography [CT] scans)

Ages Eligible for Study
-----------------
Minimum Age: 30 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
extracranial atherosclerosis, imaging, biomarkers