Prematurity Related Risks of Cognitive Impairment at School Age

Study Overview
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Brief Summary
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The main purpose of this study is to better evaluate prematurely born children cognitive development at school age, with regards to birth conditions but also to social situation, intra family relationships, and modalities of care. The study will be divided into 3 parts: Children born prematurely in our level III referral Center will undergo psychometric evaluation at 8 to 11 years of age by routine cognitive test. The relationships between cognitive scores and neonatal characteristics will be determined and compared to the results of schoolmates born at term. The quality of parent and child relationship will be evaluated by a standardized questionnaire allowing the evaluation of persistent stress trauma related to premature birth. An anthropologic study of the utilization of care resources will also be performed within the follow-up network taking care of these children.

Detailed Description
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Long term follow-up of vulnerable children such as infants born prematurely are generally studied without taking into account the social, familial and care resources available in the child environment. Thus, the main purpose of this study is to evaluate prematurely born children cognitive development at school age, with regards to birth conditions but also to related social situation, intra family relationships, modalities of care and utilization of care resources. The study will be divided into 3 parts: Children born prematurely in our level III referral Center will undergo psychometric evaluation at 8 to 11 years of age by routine test (WISC IV). The relationship between cognitive scores and neonatal characteristics will be determined and compared with the results of schoolmate control children, born at term. The quality of parent and child relationship will be evaluated by standardized questionnaire (Perinatal PTSD Questionnaire). This questionnaire allows evaluating persistent perinatal stress trauma related to prematurity. An anthropologic study of care and utilization of care resources will be performed within the follow-up network taking care of these children. This part will use semi-directive interviews of caregivers involved in the follow-up network. This study should allow to better correlate prematurely born children outcome with their global environment and propose improvements in care resources utilization for a better development.

Official Title
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Prematurity Related Risks of Cognitive Impairment at School Age With Regards to Social, Family and Care Environment

Conditions
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Complications of Prematurity

Intervention / Treatment
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* Behavioral: Cognitive evaluation (Wechsler IV tests)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Former premature infants aged 8-11 years School grade appropriate for their age Schoolmate control children born at term aged 8-11 years Exclusion Criteria: Any neurological sequelae

Ages Eligible for Study
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Minimum Age: 8 Years
Maximum Age: 11 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Former premature infants<br>Cognitive and executive evaluation by Wechsler IV tests | Behavioral: Cognitive evaluation (Wechsler IV tests)<br>* Children born prematurely in a level III referral Center will undergo psychometric evaluation at 8 to 11 years of age by routine test (WISC IV). The relationship between cognitive scores and neonatal characteristics will be determined and compared with the results of schoolmate control children, born at term.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cognitive and executive functions at school age in prematurely born children | Assessment by WECHSLER IV tests of children born prematurely without neurological or sensorial sequelae, and without psychological difficulties; All in school grade appropriate for their ages Controls : children born at term, matched for age and school grade. | Children at the age of 8-11 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quality of parent and children relationship | Evaluation will be performed by standardized questionnaire (Perinatal PTSD Questionnaire). This questionnaire allows evaluating persistent perinatal stress trauma related to prematurity. | Evaluated at 8-11 years of children (at the time of child cognitive evaluation) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Children, Cognitive outcome, Prematurity, Care Network, Outpatient follow-up of cognitive development, Care resources