Brain Activity by Magnetoencephalography for Children

Study Overview
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Brief Summary
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Investigate the differences in activation of brain networks during performing functional tasks for children with attention deficit hyperactivity disorder with developmental delays and typical development

Detailed Description
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A total of 12 children with attention deficit hyperactivity disorder with developmental delays and12 children with typical development will be enrolled. The following evaluations will be evaluated by the investigator who is blinded to the group's classification. Working task-related functions, such as Beery-Buktenica Visual-Motor Integration, Sensory Profile, the Chinese version of Swanson, Nolan and Pelham version IV, and Chinese version of Wechsler Intelligence Scale for Children-IV) Non-working memory-related functions, such as Pediatric Outcome Data Collection Instrument (PODCI), Child Health Questionnaire- Parent Form (CHQ-PF 28), Pediatric Quality of Life Inventory (PedsQL), and physical function (10 meters normal and fast walking, stair ascent, stair descent, and 5 times chair rising and timed up and go test) All participants will be investigated by magnetoencephalography and eye-tracking system to identify the difference of brain network activation during resting and performing tasks and between-group differences. Brain magnetic resonance image study will be performed for matching of brain localization.

Official Title
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The Brain Network Activity of Functional Tasks Performance by Magnetoencephalography for Children

Conditions
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Brain Activity

Intervention / Treatment
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* Other: Brain networks activity


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: children with attention deficit hyperactivity disorder with development delays intelligence quotient 70 or greater Exclusion Criteria: age less than 4 or greater than 10 of children intelligence quotient less than 70

Ages Eligible for Study
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Minimum Age: 4 Years
Maximum Age: 10 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Children with attention deficit hyperactivity disorder with developmental delays<br>Children with attention deficit hyperactivity disorder with developmental delays | Other: Brain networks activity<br>* The brain network activity under different conditions will be evaluated by magnetoencephalography, including resting, listen to different types of music, watch different types of videos, and interacting with cognitive stimulation conditions.<br>|
| Children with typical development<br>Children with typical development | Other: Brain networks activity<br>* The brain network activity under different conditions will be evaluated by magnetoencephalography, including resting, listen to different types of music, watch different types of videos, and interacting with cognitive stimulation conditions.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Brain network activity by magnetoencephalograph | magnetoencephalography by different types of music | measure simultaneous brain activity by different types of music through study completion, up to 6 minutes | 
| Brain network activity by magnetoencephalography | magnetoencephalography by different types of videos | measure simultaneous brain activity by different types of videos through study completion, up to 10.5 minutes | 
| Brain network activity by magnetoencephalography | magnetoencephalography by different types of interactive cognitive stimulation | measure simultaneous brain activity by different types of interactive cognitive stimulation through study completion, up to 5 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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attention deficit hyperactivity disorder, networks, magnetoencephalography, developmental delay, children