Peripherel Perfusion Index to Predict Sepsis in Very Low Birth Weight Infants

Study Overview
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Brief Summary
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To explore the predictive value of peripheral perfusion index in late onset sepsis of very low birth weight infants , obtain the threshold by observing the perfusion index of very low birth-weight infants within one month after birth, this value can be used as a threshold to predict late onset sepsis in very low birth weight infants.

Detailed Description
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From the day the very low birth weight infant was admitted to hospital, monitoring was recorded once a day, and continuous monitoring was recorded for 1 month. Before collection, the infant was confirmed to be in supine position with neutral temperature, and at the same time, the infant was in a quiet state, without the contact and operation of medical personnel. This study will first use LMS curve to fit the trend of perfusion index in very low birth weight infants within one month after birth.The perfusion index threshold of the outcome index was determined by ROC curve.

Official Title
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Study of Peripherel Perfusion Index to Predict Late Onset Sepsis in Very Low Birth Weight Infants

Conditions
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VLBW - Very Low Birth Weight Infant

Intervention / Treatment
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* Other: Not applicable (cohort study)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Infants weighting <1500g Infants admitted to Children's Hospital of Fudan University

Ages Eligible for Study
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Minimum Age: 0 Hours
Maximum Age: 3 Days

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Very low birth weight infants<br>Include very low birth weight infants admitted into NICU in Children's hospital of Fudan University, and prospectively observe whether they get late onset sepsis. | Other: Not applicable (cohort study)<br>* This is a prospective observational study and does not include interventions. The exposure is peripheral perfusion index and the outcome is the incidence of late onset sepsis. From the day when the very low birth weight infant is admitted into hospital, PPI monitoring should be recorded once a day, and continuous monitoring would be recorded until 1 month after birth. Before collection, the infant will be confirmed to be in supine position with neutral temperature, and at the same time, the infant will be in a quiet state, without the contact and operation of medical personnel.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of late onset sepsis | Neonatal infection occurring 7 days after birth, confirmed by a doctor through laboratory positive indicators or clinical diagnosis | From admission into the ward to one month after birth | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Late onset sepsis, Peripheral perfusion index