Bronchial Hyperreactivity in Atopic Dermatitis Patients - a 10 Year Follow-up

Study Overview
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Brief Summary
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The investigators will contact 64 patients with atopic dermatitis (AD) who participated in a long-term tacrolimus ointment trial in Helsinki 10 years ago, and ask them to participate in this follow-up study. The investigators will do the same tests as 10 years ago, i.e. bronchial hyperreactivity, skin prick tests, serum-IgE, Mantoux-test (2 TU), and questionnaires about asthma and allergic rhinitis symptoms. The investigators also collect data about their AD medication during the last 10 years. The investigators hypothesis is that when the skin condition improves in patients with AD the brochial hyperreactivity improves. The investigators also want to study whether different treatments play a role in the development or resolution of bronchial hyperreactivity.

Detailed Description
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We will by letters and telephone contact all patients (n=64) who fulfill the inclusion criteria for this study. The testing in the study (bronchial hyperreactivity, skin prick testing, serum IgE) is cross-sectional, but we retrospectively collect data from the last 10 years about the skin condition and medication for atopic diseases.

Official Title
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Bronchial Hyperreactivity in Atopic Dermatitis Patients - a 10 Year Follow-up

Conditions
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Atopic Dermatitis

Intervention / Treatment
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* Procedure: Histamine provocation
* Procedure: Skin prick tests
* Procedure: Serum IgE blood testing
* Procedure: Mantoux-testing


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient has participated in the FG-506-06-21 study in Helsinki Patient was tested for bronchial hyperreactivity in the years 1998-2000 Patient gives signed informed consent to participate in this study
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| AD patients<br>AD patients who fulfill the inclusion criteria for the study | Procedure: Histamine provocation<br>* A dosimetric histamine challenge test in which the provocative dose of inhaled histamine producing a decrease of 15% in FEV1 is measured.<br>Procedure: Skin prick tests<br>* Skin prick testing will be performed for: birch, timothy, mugwort, alder, pine, cat, dog, horse, house dust mite, Cladosporium herbarum.<br>Procedure: Serum IgE blood testing<br>* One blood test to measure total serum IgE<br>Procedure: Mantoux-testing<br>* Tuberculin (2 TU) s.c. on the forearm. The test is read after 72 hours.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Bronchial hyperreactivity |  | 10 year follow-up | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Skin prick tests |  | 10 year follow-up | 
| Serum-IgE |  | 10-year follow-up | 
| Mantoux-test |  | 72 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Atopic dermatitis, Bronchial hyperreactivity, Skin prick tests, Serum IgE, Mantoux test