Study of Human Leukocyte Antigen (HLA) Polymorphisms in Patients With Rheumatoid Arthritis

Study Overview
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Brief Summary
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Rheumatoid arthritis (RA), affects between 0.3% and 1.0% of the population, it can lead to progressive joint destruction and severe disability. To date, two RA genetic susceptibility factors have been identified: HLA-DRB1-SE (Shared epitope) and PTPN22 620W alleles. The predictive value of the alleles for diagnosis of RA was previously investigated in cohorts of caucasians patients with early unclassified arthritis that showed restrained association between RA and HLA-SE. Despite the contribution of HLA to the overall genetic risk has been estimated to range from 30% to 50%, it has never been studied in the French west-Indian population.

Official Title
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Study of HLA Polymorphisms in French West-Indian Patients With Rheumatoid Arthritis : A Case Control Study

Conditions
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Rheumatoid Arthritis

Intervention / Treatment
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* Biological: Collect of 10 ml of peripheric blood for DNA extraction


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosis of Rheumatoid Arthritis according to ACR criteria Come from French West Indies (At least 3 grandparents are African-Caribbean) Sign written informed consent Exclusion Criteria: Minor Patient with no Rheumatoid Arthritis according to ACR criteria Patient does not agree for a genetic study For the control Inclusion Criteria: Blood donor Sign written informed consent Patient with no Rheumatoid Arthritis according to ACR criteria Come from French West Indies (At least 3 grandparents are African-Caribbean) Exclusion Criteria: Minor Patient does not agree for a genetic study

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Biological: Collect of 10 ml of peripheric blood for DNA extraction|After signed written consent, all patients have a clinic exam in order to assess the presence of eligibility criteria (Patient with Rheumatoid Arthritis that fulfil the ACR criteria of diagnosis)|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Difference of distribution of HLA alleles in patients and in healthy controls |  | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The association between the different HLA alleles among French West-Indian RA patients and the autoantibodies production. |  | 1 day | 
| The association between the different HLA alleles among French West-Indian RA patients and the radiological damage. |  | 1 day | 
| The association between the different HLA alleles among French West-Indian RA patients and the response to therapy |  | 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Rheumatoid Arthritis, Rheumatoid Arthritis according to ACR criteria of diagnosis