Early Incidence of Occupational Asthma Among Bakers, Pastry-makers and Hairdressers

Study Overview
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Brief Summary
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Background: Occupational exposures are thought to be responsible for 10-15% of new-onset asthma cases in adults, with disparities across sectors. Because most of the data are derived from registries and cross-sectional studies, little is known about incidence of occupational asthma (OA) during the first years after inception of exposure. This study focuses on this early asthma onset period among young workers in the bakery, pastry making and hairdressing sectors in order to assess early incidence of OA in these at risk occupations according to exposure duration, and to identify risk factors of OA. Methods: This study is a longitudinal retrospective study with a nested case-control to identify risk factors of OA. The assessment of incidence evolution is made by exploring a series of promotions (or retrospective cohorts) with increasing duration since at work. The study population is composed of subjects who graduated between 2001 and 2006 in sectors where they experience exposure to organic or inorganic allergenic or irritant compounds (with an objective of 150 subjects by year) and 250 young workers with no specific occupational exposure. This study is a descriptive, monocentric, longitudinal and retrospective study with cross-sectional measurements.

Official Title
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Evolution of the Incidence of Occupational Asthma at the Beginning of the Activity of Young Bakers, Pastry-makers and Hairdressers, and Exploration of Its Risk Factors

Conditions
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Occupational Asthma

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: for the exposed group: to be graduated between 2001 and 2006 from nine vocational schools in Lorraine, North-Eastern France for the non-exposed group: to be graduated in 2001 in the sale or the food sectors (butcher, pork butcher, caterer, cook job,…) from the same vocational schools Exclusion Criteria: asthma diagnosed before apprenticeship for the non-exposed group: to have worked previously or later in a sector at risk with OA
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Young workers<br>Exposed young workers graduated in sectors at risk of occupational asthma (bakery, pastry-making or hairdressing) Non-exposed young workers graduated in sectors without specific occupational exposure as the sale or the food sectors. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The early incidence of OA among young workers according to their sector of activity and exposure duration. |  | 3-6 months after tle last inclusion | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The identification of risk factors of OA. |  | 3-6 months after the last inclusion | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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incidence, young workers, occupations at risk, public health, epidemiology, polymorphisms, gentic