Livedoid Vasculopathy: Strong Association With Smoking, Weak Association With Thrombophilia

Study Overview
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Brief Summary
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A screening of patient histories at the clinics of Dermatology of the universities of Zurich, Basel and Bern is performed in order to identify patients with a history of Livedoid vasculopathy. Patients with a history of livedoid vasculopathy are asked to participate in the study. After reading the patient information and if the informed consent is signed patients are included in the study. Patients are questioned about their smoking history and blood is drawn in order to perform a screening for thrombophilia.

Detailed Description
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A screening of patient histories at the clinics of Dermatology of the universities of Zurich, Basel and Bern is performed in order to identify patients with a history of Livedoid vasculopathy. Patients with a history of livedoid vasculopathy are asked to participate in the study. The presence of Livedoid vasculopathy must be confirmed by a histologic specimen. After reading the patient information and if the informed consent is signed patients are included in the study. Patients are questioned about their smoking history and blood is drawn in order to perform a screening for thrombophilia. The presence of a history of smoking and thrombophilia is compared to the general Swiss population.

Official Title
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Livedoid Vasculopathy: Strong Association With Smoking, Weak Association With Thrombophilia

Conditions
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Livedoid Vasculitis

Intervention / Treatment
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* Other: Thrombophilia screening


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: History of livedoid vasculopathy Exclusion Criteria: Diagnosis was not proved by biopsy specimen A different reason than livedoid vasculopathy has been found for the symptoms of the patient No informed consent by the patient

Ages Eligible for Study
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Minimum Age: 10 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Thrombophilia screening<br>Patients with livedoid vasculopathy. Investigated by thrombophilia screening | Other: Thrombophilia screening<br>* No intervention. Blood is drawn for analysis.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Smoking history: Patients will be asked if they currently smoke or if they are former smokers. If one of both items is yes, it means a positive answer. | The primary endpoint is the comparison of a positive smoking history and other cardiovascular risk factors of patients with livedoid vasculopathy with the Swiss general population. | 22 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Thrombophilia screening: the following parameters will be determined in every participant: Factor V Leiden, Prothrombin 20210; Protein C, Protein S, Antithrombin III, Beta 2 Glykoprotein 1, Lupus Antikoagulans | The secondary endpoint is the search for thrombophilia in patients with livedoid vasculopathy. | 22 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Livedoid Vasculitis, smoking, thrombophilia