Anthropometric, Metabolic, Cardiovascular and Symptomatic Profile in Postmenopausal Women

Study Overview
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Brief Summary
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The purpose of this study is to investigate anthropometric, metabolic, cardiovascular and symptomatic profiles in postmenopausal women.

Detailed Description
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When aging, the body composition changes, leading to a reduction of muscle mass and strength, and to an increase in total body fat. These body composition changes have especially been observed in postmenopausal women, due to the hormonal changes taking place. After the menopause, the gynoid fat distribution with fat deposits in the gluteo-femoral region changes to an android fat distribution with an increased upper body fat, especially in the abdominal region. These consequences of the menopause associated with a decrease in aerobic capacity and reduced total energy expenditure may lead to the metabolic syndrome (MetS). The aim of this study was to investigate the anthropometric, metabolic, cardiovascular and symptomatic profile in gynoid and android postmenopausal women.

Official Title
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Impact of Fat Distribution on Metabolic, Cardiovascular and Symptomatic Aspects in Postmenopausal Women

Conditions
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Postmenopausal Disorder

Intervention / Treatment
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* Other: Clinical exams


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Postmenopausal women Caucasian 50-60 years of age Exclusion Criteria: Neurological disease Pulmonary disease Cardiac disease Oncological disease Musculotendinous or articular injuries Hormone replacement therapy Cigarette smoking

Ages Eligible for Study
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Minimum Age: 50 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| android postmenopausal women<br>Clinical exams | Other: Clinical exams<br>* Physiological and biochemical tests; quality of life questionnaire; body composition measurement<br>|
| gynoid postmenopausal women<br>Clinical exams | Other: Clinical exams<br>* Physiological and biochemical tests; quality of life questionnaire; body composition measurement<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Relationships between postmenopause and fat distribution | Anthropometric measurements: waist-to-hip ratio and body mass index | Baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of aerobic capacity between android and gynoid postmenopausal women | Progressive aerobic testing on treadmill (Modified Bruce Protocol): estimated maximum oxygen consumption; metabolic equivalents; blood pressure; heart rate | Baseline | 
| Comparison of metabolic parameters between android and gynoid postmenopausal women | Biochemical tests: the serum level of estradiol, urea, creatinine, triglycerides, total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, very low-density lipoprotein (VLDL) cholesterol, insulin and glucose | Baseline | 
| Comparison of quality of life between android and gynoid postmenopausal women | Menopause Rating Scale (MRS): somatic symptoms; psychological symptoms; urogenital-sexual problems | Baseline | 
| Comparison of the body composition between android and gynoid postmenopausal women | Body composition: bipolar electrical bioimpedance (body fat and lean mass) and skinfolds (triceps, subscapular, suprailiac, abdominal, anterior thigh, medial calf) | Baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Postmenopausal Women, Body Composition, Metabolic Syndrome, Menopause Symptoms