Comparison of Nitrofurantoin and Calcium Hydroxide as Intracanal Medicaments in Alleviating Post-operative Pain

Study Overview
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Brief Summary
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Intracanal medicaments have been frequently used in patients with endodontic and periradicular infection for the elimination of microorganisms. Commonly used includes Double Antibiotic Paste, Triple Antibiotic Paste, and Calcium Hydroxide. This study aims to compare the efficacy in alleviating pain between intracanal medicaments Nitrofurantoin and Calcium Hydroxide Paste. 60 patients were randomly divided into 3 groups, each group having 20 patients as following: Group 1: Nitrofurantoin, Group 2: Calcium Hydroxide and Group 3: Control. Preoperative pain was recorded using a numerical pain scale. Pre-operative pain score was initially recorded, followed by Post-operative pain at 12, 24, 48, and 72 hours. Nitrofurantoin has been proven to be an effective intracanal medicament in alleviating immediate post-operative pain in patients with symptomatic irreversible pulpitis as compared to calcium hydroxide.

Detailed Description
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Intracanal medicaments have been frequently used in patients with endodontic and periradicular infection for the elimination of microorganisms. Commonly used includes Double Antibiotic Paste, Triple Antibiotic Paste, and Calcium Hydroxide. This study aims to compare the efficacy in alleviating pain between intracanal medicaments Nitrofurantoin and Calcium Hydroxide Paste. 60 patients were randomly divided into 3 groups, each group having 20 patients as following: Group 1: Nitrofurantoin, Group 2: Calcium Hydroxide and Group 3: Control. Preoperative pain was recorded using a numerical pain scale. After access preparation, chemomechanical preparation was performed with subsequent placement of intracanal medicaments. Pre-operative pain score was initially recorded, followed by Post-operative pain at 12, 24, 48, and 72 hours, respectively. Root canal treatment was performed in single root teeth with patients suffering from symptomatic irreversible pulpitis. Total of 20 patients were randomized into 3 groups. Majority of the patients in all 3 groups initially presented with moderate to severe pre-operative pain. After 72 Hours post-operatively, 50% patients in group 1 reported no pain, while 5% patients in both group 2 and 3 had no pain. Pain significantly subsided in group 1 as compared to group 2 and 3. Regarding age and gender, both had no significant relationship with the pain scores in all of the 3 groups. Nitrofurantoin has been proven to be an effective intracanal medicament in alleviating immediate post-operative pain in patients with symptomatic irreversible pulpitis as compared to calcium hydroxide. While the control group with no intracanal medicament showed little reduction in pain scores. So, nitrofurantoin can be used as a substitute to currently available standard intracanal medicaments.

Official Title
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Comparison of Single Antibiotic Paste Nitrofurantoin and Calcium Hydroxide Paste as Intracanal Medicaments in Alleviating Post-Operative Pain in Patients With Symptomatic Irreversible Pulpitis -A Randomized Controlled Trial

Conditions
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Pain, Postoperative, Irreversible Pulpitis

Intervention / Treatment
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* Drug: Nitrofurantoin 100 MG


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: No medical history no age restrictions no history of allergy to medications used in root canal treatment patients suffering from Symptomatic Irreversible Pulpitis Exclusion Criteria: Patients who were not suitable for conventional root canal treatment multirooted teeth
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Nitrofurantoin<br>Measuring pain score using numerical pain scale post-operatively at different time intervals. | Drug: Nitrofurantoin 100 MG<br>* Comparison of alleviating post-operative pain between nitrofurantoin and calcium hydroxide<br>* Other names: Calcium Hydroxide;|
| Experimental: Calcium Hydroxide<br>Measuring pain score using numerical pain scale post-operatively at different time intervals. | Drug: Nitrofurantoin 100 MG<br>* Comparison of alleviating post-operative pain between nitrofurantoin and calcium hydroxide<br>* Other names: Calcium Hydroxide;|
| Experimental: Control<br>Measuring pain score using numerical pain scale post-operatively at different time intervals. | Drug: Nitrofurantoin 100 MG<br>* Comparison of alleviating post-operative pain between nitrofurantoin and calcium hydroxide<br>* Other names: Calcium Hydroxide;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Group 1: Nitrofurantoin | Measuring incidence of Post-operative Pain using Numerical Pain Scale | 5 months | 
| Group 2: Calcium Hydroxide | Measuring incidence of Post-operative Pain using Numerical Pain Scale | 5 months | 
| Group 3: Control | Measuring incidence of Post-operative Pain using Numerical Pain Scale | 5 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Nitrofurantoin, Calcium hydroxide, Intracanal medicaments, Irreversible pulpitis