linjc16/ctgov huggingface dataset:
Behavioral Change Simulation Experiment Regarding Dentists' Repair Behavior

Study Overview
=================
Brief Summary
-----------------
The aim of the present study is to determine the effect of two potential interventions on dentists' behavior regarding the repair of partially defective dental restorations.

Detailed Description
-----------------
Two potential interventions are delivered as written instructions to the participants. Dentists are asked to indicate their treatment preference for two given clinical scenarios (consisting of case vignettes, clinical photos, and radiographs) in two questionnaires prior (baseline data) and after receiving the intervention. Based on these data, the simulated behavior change (i.e. to repair or not to repair) will be assessed.

Official Title
-----------------
Behavioral Change Simulation Experiment Regarding Dentists' Repair Behavior

Conditions
-----------------
Behavior

Intervention / Treatment
-----------------
* Other: Guideline
* Other: Treatment fee item


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: General dentists, working in Germany and being listed in an address databse (www.adressdiscount.de) Exclusion Criteria: Dentists who are not listed in the above-mentioned database Dentists who have previously declined to participate in future research from our department.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Either of two potential interventions is delivered as written instruction to the participants
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Intervention Guideline<br>Participants are given written information (a hypothetical new guideline). | Other: Guideline<br>* Hypothetical guideline regarding the indications and treatment steps involved in dental restoration repair.<br>|
| Experimental: Intervention Treatment fee item<br>Participants are given written information about a hypothetical new treatment fee item. | Other: Treatment fee item<br>* Arrangement of a hypothetical treatment fee item which can be charged in addition to the actual repair restoration.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Simulated behavior change | Simulated behavior change, indicated by the proportion of dentists selecting repairs as their treatment preference for the given clinical scenarios. | 10 Minutes | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
decision-making, repair behavior, questionnaire
Validation of Osmolarity System: Clinical Usability Study

Study Overview
=================
Brief Summary
-----------------
Confirmatory trial to validate usability of a new portable osmolarity testing device.

Detailed Description
-----------------
Confirmatory trial at 3 sites in Canada to validate usability of an ocular osmolarity testing device.

Official Title
-----------------
Validation of Osmolarity System: Clinical Usability Study

Conditions
-----------------
Dry Eye

Intervention / Treatment
-----------------
* Diagnostic Test: Osmolarity Test


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Able to provide consent Exclusion Criteria: Ocular pathology (other than Dry Eye)

Ages Eligible for Study
-----------------
Minimum Age: 22 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Normal Eye Group<br>Normal eye receiving Osmolarity Test | Diagnostic Test: Osmolarity Test<br>* Osmolarity Test<br>|
| DED Group<br>Dry Eye Disease receiving Osmolarity Test | Diagnostic Test: Osmolarity Test<br>* Osmolarity Test<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Osmolarity Level | Osmolarity Level | Baseline |
Pulse Pressure Variation for Prediction of Fluid Responsiveness in Coronary Artery Disease Patients With Diastolic Dysfunction

Study Overview
=================
Brief Summary
-----------------
The investigators hypothesized that predictability of pulse pressure variation (PPV) on fluid responsiveness would be reduced in patients with coronary disease who have diastolic dysfunction.

Conditions
-----------------
Fluid Responsiveness Predictability

Intervention / Treatment
-----------------
* Drug: Fluid loading (Voluven)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients older than 20 years scheduled for elective coronary artery bypass grafting normal diastolic function (E/E' < 8) or diastolic dysfunction (E/E' >15) according to preoperative Echocardiographic evaluation Exclusion Criteria: arrythmia, reduced left ventricular function (ejection fraction < 40%) valvular heart disease requiring concomitant surgical correction pulmonary hypertension (mean pulmonary arterial pressure ≥30 mm Hg) peripheral arterial occlusive disease, pulmonary disease (asthma, chronic obstructive pulmonary disease, and lung resection) end-stage renal disease

Ages Eligible for Study
-----------------
Minimum Age: 20 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Normal diastolic function group<br> | Drug: Fluid loading (Voluven)<br>* HES 130/0.4 (VoluvenⓇ, Fresenius Kabi, Graz, Austria) 8ml / kg loading during 15 minutes after induction of anesthesia on both groups<br>* Other names: Fluid loading;|
| Active Comparator: Diastolic dysfunction group<br> | Drug: Fluid loading (Voluven)<br>* HES 130/0.4 (VoluvenⓇ, Fresenius Kabi, Graz, Austria) 8ml / kg loading during 15 minutes after induction of anesthesia on both groups<br>* Other names: Fluid loading;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| predictability of pulse pressure variation (PPV) on fluid responsiveness in patients with coronary disease who have normal diastolic function and diastolic dysfunction. | After induction of anesthesia and applying mechanical ventilation, hemodynamic parameters (including PPV measured by Philips IntelliVue MP 70®) were recorded | 10 minutes after fluid replacement | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
pulse pressure variation, fluid responsiveness, diastolic dysfunction
Battlefield Acupuncture for Pain in Hidradenitis Suppurativa

Study Overview
=================
Brief Summary
-----------------
The investigators will investigate battlefield acupuncture as a treatment for the pain of hidradenitis suppurativa.

Detailed Description
-----------------
Participants will report their pain level daily for 4 weeks. At week 2 and 3, they will get acupuncture in the ears.

Official Title
-----------------
Battlefield Acupuncture to Treat Pain in Hidradenitis Suppurativa

Conditions
-----------------
Hidradenitis Suppurativa

Intervention / Treatment
-----------------
* Procedure: Battlefield Acupuncture
* Procedure: Sham Acupuncture


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age 18 years or older dermatologist-confirmed diagnosis of hidradenitis suppurativa significant pain from hidradenitis at least twice weekly stable treatment regimen for hidradenitis during study period Exclusion Criteria: disease or disfigurement of the ear that prevents battlefield acupuncture of the ears other chronic pain that will interfere with the ability to rate hidradenitis pain

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Blinded, randomized trial
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Treatment<br>2 treatments of battlefield acupuncture to the bilateral ears spaced one week apart | Procedure: Battlefield Acupuncture<br>* Acupuncture at 5 points on the ears<br>|
| Sham Comparator: Control<br>2 treatments with sham acupuncture to the bilateral ears at acupuncture points not associated with pain relief (2 liver and 1 stomach) | Procedure: Sham Acupuncture<br>* Sham acupuncture in 2 points for liver and 1 point for stomach<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Pain Numerical Rating Score | Difference in Average Patient self-reported Pain Numerical Rating Score from 0-10, comparing average from 2 weeks prior to treatment with average from 2 weeks after treatment | Average Score from scores Recorded daily for 4 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
acupuncture, pain, battlefield acupuncture, hidradenitis
Physician-nurse Team to Reduce Emergency Department (ED) Overcrowding

Study Overview
=================
Brief Summary
-----------------
The objective of this study is to explore the impact of a physician-nurse team supervising patient's flow on ED length of stay

Detailed Description
-----------------
A physician-nurse team will be in charge of patients flow in the ED during intervention periods. During control periods, no team will be present. The impact of this team on Ed length of stay will be assessed.

Official Title
-----------------
Impact of Physician-nurse Team on ED Length of Stay

Conditions
-----------------
Triage

Intervention / Treatment
-----------------
* Behavioral: Physician-nurse team supervision


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: all adult patients > 16 years presenting to the ED Exclusion Criteria: no

Ages Eligible for Study
-----------------
Minimum Age: 16 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Physician-nurse team<br> | Behavioral: Physician-nurse team supervision<br>* Physician-nurse team will supervise patient's flow in the ED<br>* Other names: No name;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| ED length of stay |  | 3 months |
Health Outcomes in Rheumatoid Arthritis

Study Overview
=================
Brief Summary
-----------------
This research is being done to help us learn about how different factors related to treatment affect rheumatoid arthritis (RA). This is not a treatment study. We will follow the patient for one year as he or she receives usual treatment from his or her rheumatologist. Up to 360 adults with RA may join this study.

Official Title
-----------------
Health Outcomes in Rheumatoid Arthritis

Conditions
-----------------
Rheumatoid Arthritis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Males and females age 19 or older Current active, adult-onset rheumatoid arthritis who meet American College of Rheumatology (ACR) criteria for RA and have: (ACR functional class I-III), defined as: 3 or more swollen or tender joints and Morning stiffness of 45min or longer OR judged by their rheumatologist to have active disease No evidence of other inflammatory diseases (e.g., Crohn's, IBS) Functional class I, II or III Exclusion Criteria: Individuals with significant cardiovascular disease (CHF, stroke, MI) Unwilling to have medications monitored and/or comply with protocol Not fluent in English Planning to move from area within next year or change health insurance (which would preclude ongoing care by a Johns Hopkins rheumatologist) Enrolled in study evaluating efficacy of new or existing RA medications

Ages Eligible for Study
-----------------
Minimum Age: 19 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
rheumatoid arthritis, mood, adherence, medication
Osteoporosis Research Registry

Study Overview
=================
Brief Summary
-----------------
The aim of this research registry is to collect information on individuals with osteoporosis, those with risk factors for osteoporosis, and comparative healthy controls. Bone mineral density measurements will be done on these individuals to determine bone health.

Detailed Description
-----------------
The goal of this project is to develop a registry of research subjects with OP, with a risk of developing OP, and healthy controls. DXA scans will be performed on willing individuals at the spine, hips, and forearms and possibly the legs and heels in order to determine BMD. Subjects will also be asked to provide two (10 ml) blood samples, which may be used to analyze Vitamin D levels and/or other bone markers. By participating in the registry, subjects will be considered for current and future clinical research studies.

Official Title
-----------------
Osteoporosis Research Registry

Conditions
-----------------
Osteoporosis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Any subjects who give written informed consent Exclusion Criteria: Any individual who is not willing or able to give written informed consent
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Osteoporosis<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| BMD |  | 0 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Bone markers |  | 0 months |
Effect of Oats on Lipid Profile

Study Overview
=================
Brief Summary
-----------------
A randomized control trial to assess the effect of oats on lipid profile of mildly hypercholesterolemic subjects. Subjects consumed 35g of oats twice daily (total of 70g / day) in place of carbohydrates as part of their usual diet. 70 grams of oats provide 3 grams of soluble fiber. Control group consumed the usual diet. Subjects followed up for 4 weeks. In total 3 assessment visits of the subjects planned for the study period.

Official Title
-----------------
A Randomized Controlled Trial to Evaluate the Efficacy of 3 g of Soluble Fiber From Oats on the Lipid Profile of Men and Women With Elevated Lipid Levels Aged Between 20 and 50 Years

Conditions
-----------------
Mildly Hypercholesterolemic Subjects

Intervention / Treatment
-----------------
* Other: Oats


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Men and women between 20 and 50 years old Total Cholesterol: ≥ 200 mg/dL and < 240mg/dL Availability and willingness to follow study protocol Stable body weight for previous 3 months (not more than 5% weight change) Exclusion Criteria: Subjects already on lipid lowering drugs LDL-c > 190 mg/dL Total cholesterol <200 mg/dL and >240 mg/dL Subjects with serum creatinine levels > 1.3 mg/dL (female) or 1.4 mg/dL (male), nephropathy, evidence of hepatic disease or history of alcohol abuse Baseline Triglycerides: > 300 mg/dL Diabetes (Type 1 or Type 2) as diagnosed by a physician Uncontrolled hyperthyroidism (as per physician's discretion) Uncontrolled hypertension (as per physician's discretion) Acute infections or chronic debilitating diseases like tuberculosis, malignancy, HIV infection etc. Any life threatening serious disorder of the liver, kidneys, heart, lungs or other organs by history Irritable bowel syndrome by history Unwillingness to give written informed consent for participation in the study. Pregnancy & lactation (by history) Severe end organ damage Subjects with allergy to oats Heavy smokers (smoking more than 5 cigarettes per day)

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Oats<br>70 grams oats | Other: Oats<br> <br> |
| Placebo Comparator: usual diet and exercise<br>usual diet and exercise | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| reduction of total cholesterol |  | 4 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| LDL-c |  | 4 weeks | 
| Triglycerides |  | 4 weeks | 
| Blood pressure |  | 4 weeks |
Inflammation and Cellular Immunity in Vaginal Tissue in Patients With Pelvic Organ Prolapse

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to investigate the inflammatory and maturation processes of immature myeloid cells (IMC) in the vaginal tissue in women with advanced pelvic organ prolapse (POP) (stage III-IV) and in normal non-POP controls. We hypothesize that the processes contributing to POP may be related to immune response and changes in myeloid cell populations and the cytokine environment.

Official Title
-----------------
Inflammation and Cellular Immunity in Vaginal Tissue in Patients With Pelvic Organ Prolapse

Conditions
-----------------
Pelvic Organ Prolapse

Intervention / Treatment
-----------------
* Procedure: Hysterectomy
* Procedure: Colporrhaphy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Women with POP undergoing colporrhaphy Women undergoing hysterectomy Exclusion Criteria: Autoimmune and connective tissue disorders Cancer in genital tract

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
Female

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| POP Group<br>Women with POP undergoing surgery in our OB/GYN department. | Procedure: Colporrhaphy<br>* Surgery performed on women with POP<br>|
| Non-POP Group<br>Women undergoing hysterectomy for other indications. | Procedure: Hysterectomy<br>* Surgery performed on women with a variety of gynecological indications<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Immune response in POP | Tissue biopsy will analyzed for IMC and compared to control group | Two weeks | 
| Cytokine environment in POP | Tissue biopsy will analyzed for cytokine environment and compared to control group | Two weeks |
The Long QT Syndrome in Pregnancy

Study Overview
=================
Brief Summary
-----------------
Long QT Syndrome (LQTS) is a disease of young adults and can affect women of child bearing age. Suffers of LQTS are at risk of ventricular dysrhythmias including torsades de pointes and ventricular fibrillation. Pregnancy increases the chance that any mother may have an abnormal heart rhythm or arrhythmia. This chance is higher with the LQTS. There are only a few reported cases of women with the LQTS having a baby in the medical literature. This can make it difficult for the doctor caring for a pregnant woman with the long QT syndrome - especially should they need an anesthetic. We would like to study as many women who have had a baby who have the long QT syndrome to give us a better idea of whether there are any arrhythmias occurring at the time of delivery.

Detailed Description
-----------------
This will be a retrospective analysis of all LQTS women managed at St. Paul's or BC Women's who have been pregnant in the last 5 years. These two hospitals both have a provincial role in the care of pregnant women, BC Women's as the designated provincial tertiary maternity care referral centre, and St. Paul's through its provincial PATCH clinic. Using the data from these two centres should capture the majority of LQTS cases in parturients in the province. We will search for these women from the Department of Anesthesia BC Women's consult database, the St. Paul's Cardiac Obstetrical Care database, and BC Women's Health Records using International Classification of Diseases - 10 coding for long QT. Then, after obtaining patient consent, review the charts collecting data using the data entry form. The cases will then be compared and any conclusions into the different anesthetic managements made.

Official Title
-----------------
The Long QT Syndrome in Pregnancy

Conditions
-----------------
Long QT Syndrome

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Pregnant women with diagnoses of Long QT Syndrome, Romano Ward and Jervell - Lange Nielson Syndrome who delivered at BC Women's Hospital or St Paul's Hospital. Exclusion Criteria: Non consent to participation in the study Age less than 19 Non English speaker
Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Long QT Syndrome, Romano Ward, Jervell-Lange Nielson Syndrome