Rate of Spontaneous Stone Passage as Assessed Using Urinary Ultrasonography and Direct Urinary System Radiography

Study Overview
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Brief Summary
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To evaluate the effect of masturbation on the spontaneous expulsion of distal ureteral stones 5-10 mm in size.

Detailed Description
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This prospective randomized controlled study was performed between February 2018 and March 2020 after obtaining ethics committee approval.A total of 128 men with distal ureteral stones were randomly divided into 3 groups. All patients received standard medical therapy. Patients in group 1 (n=43) were instructed to masturbate at least 3-4 times a week, patients in group 2 (n=41) received tamsulosin 0.4 mg/day, and patients in group 3 (controls, n=44) received standard medical therapy alone. Rates of expulsion, need for analgesic, and ureterorenoscopic lithotripsy were compared between the groups.

Official Title
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Evaluation of the Effect of Masturbation on Distal Ureteral Stones: A Prospective Randomized Controlled Study

Conditions
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Ureteral Calculi, Masturbation

Intervention / Treatment
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* Procedure: Endoscopic ureterolitotripsy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age ≥18 years presenting with renal colic and inguinal or lumbar pain being diagnosed as having distal ureteral stones ≥5 mm and <10 mm in size Exclusion Criteria: age <18 years, stones <5 mm or ≥10 mm in size, intermediate (stones on the ureter-iliac artery cross) proximal ureteral stones, multiple ureteral stones, presence of urinary infection, renal insufficiency, high creatinine level, severe hydroureteronephrosis, history of open or endoscopic ureteral surgery, vesicoureteral reflux, neurogenic bladder, erectile dysfunction, inability or refusal to masturbate for any reason (such as religious beliefs)

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Group 1<br>The patients in group 1 were instructed to masturbate at least 3-4 times a week | Procedure: Endoscopic ureterolitotripsy<br>* Endoscopic ureterolithotripsy<br>|
| Other: Group 2<br>The patients in group 2 were prescribed oral tamsulosin 0.4 mg once daily | Procedure: Endoscopic ureterolitotripsy<br>* Endoscopic ureterolithotripsy<br>|
| No Intervention: Group 3<br>The patients in group 3 acted as controls and received only standard medical therapy | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The rates of spontaneous distal ureteral stone (5-10 mm size) passage after 4 weeks masturbation | The rates of spontaneous distal ureteral stone (5-10 mm size) passage of patients who were instructed to masturbate at least 3-4 times a week (Group1); received tamsulosin 0.4 mg/day (Group2); received standard medical therapy alone Group3. | 4 weeks |