linjc16/ctgov huggingface dataset:
Angiotensin II Pathway and Acute Lung Injury

Study Overview
=================
Brief Summary
-----------------
Acute type A aortic dissection is often accompanied by postoperative pulmonary complications, the cause of which is not fully understood.Angiotensin II is an important component of the renin-angiotensin system (RAS), which has been suggested to be involved in the development of aortic dissection and pulmonary inflammation.The purpose of this study was to investigate the role and mechanism of angiotensin II pathway in postoperative pulmonary complications after acute type A aortic dissection, and to provide reference for clinical application

Official Title
-----------------
The Mechanism Research of Angiotensin II Pathway and Acute Lung Injury

Conditions
-----------------
Aortic Dissection

Intervention / Treatment
-----------------
* Other: No intervention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients undergoing surgery for acute type A aortic dissection age between 18 to 80 Exclusion Criteria: perioperative severe cardiac insufficiency rejection of consent

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Hypoxemia group<br>oxygenation index (OI)≤200 | Other: No intervention<br>* No intervention<br>|
| Non-hypoxemia group<br>oxygenation index (OI)>200 | Other: No intervention<br>* No intervention<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The difference concentrations of Ang II，ACE2 and miR-145 in serum between patients with and without postoperative hypoxemia. | Blood samples were taken within 24 hours after operation to detect the contents of Ang II, ACE2 and miR-145 in serum. | Within 24 hours after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The risk factors for postoperative hypoxemia in Stanford type A acute aortic dissection patients. | Basic characteristics, intraoperative details, biochemical parameters and outcome results were obtained, and blood was collected within 24 hours after surgery for the measurement of ANG II, sACE2 and mir-145 concentrations. Univariate analysis was first performed to identify the potential risk factors for postoperative hypoxemia. Multivariate logistic regression analysis was performed for factors with P < 0.05 or that were considered clinically important. | up to 60 days | 
| Duration of Stay in the Intensive Care Unit | Duration of Stay in the intensive care unit after surgery | up to 60 days |
Influence of Acetylsalicylic Acid and Low Molecular Weight Heparins on the Incidence of Renal Hematoma of Shockwave Lithotripsy

Study Overview
=================
Brief Summary
-----------------
Retrospective Analysis of patients that received shockwave lithotripsy as Treatment of ureteral or kidney Stones. Condition examinated is the effect of low molecular weight Heparins and acetylsalicylic acid on the Formation of renal hematoma after shockwave lithotripsy. Primary outcome is documented hematoma in a postoperative ultrasound control. Secondary outcomes are perioperative complication, Need for erythrocyte tranfusion, interventions for bleeding control, readmission or death within 30 days.

Official Title
-----------------
Influence of Acetylsalicylic Acid and Low Molecular Weight Heparins on the Incidence of Renal Hematoma of Shockwave Lithotripsy

Conditions
-----------------
Urolithiasis, Renal Hematoma

Intervention / Treatment
-----------------
* Drug: Acetylsalicylic acid
* Drug: low molecular weight heparin


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: consent Stones in kidney and proximal Ureter Treatment with shockwave lithotripsy for urolithiasis between January 2009 and September 2015 at Kantonsspital Winterthur Exclusion Criteria: other Position of ureteral Stones missing data in Patient reports refused consent under Age limit

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Control<br> | |
| Acetylsalicylic acid<br>Patients that were on medication with Acetylsalicylic acid on the date of shockwave lithotripsy | Drug: Acetylsalicylic acid<br> <br> |
| Low Molecular weight heparin<br>Patients that were on medication with low molecular heparin on the date of shockwave lithotripsy | Drug: low molecular weight heparin<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Renal Hematoma in ultrasound control |  | first day after intervention | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Intervention for bleeding control |  | 30 days after intervention | 
| Need for erythrocyte concentrate tranfusion |  | 30 days after intervention | 
| Death |  | 30 days after intervention | 
| Hospital readmission |  | 30 days after intervention |
Cardiovascular Imaging and Biomarker Analyses (CIBER)

Study Overview
=================
Brief Summary
-----------------
Cardiovascular Imaging and Biomarker Analyses (CIBER) is a single-center, prospective and observational study evaluating the expression of novel biomarkers in patients undergoing cardiacvascular imaging within clinical routine care. It is aimed to evaluate associations with biomarker expressions with ascertained cardiac imaging parameters.

Detailed Description
-----------------
Cardiovascular Imaging and Biomarker Analyses (CIBER) is a single-center, prospective and observational study evaluating the expression of novel biomarkers in patients undergoing cardiacvascular imaging within clinical routine care. It is aimed to evaluate associations with biomarker expressions with ascertained cardiac imaging parameters. Furthermore the prognostic value of biomarkers and imaging parameters on mid-term and long-term prognosis will be evaluated. Novel biomarkers will comprise blood derived biomarkers including neurohormones, proteins, cytokines, microRNAs and metabolomics.

Official Title
-----------------
Cardiovascular Imaging and Biomarker Analyses (CIBER)

Conditions
-----------------
Coronary Artery Disease, Heart Diseases, Heart Failure

Intervention / Treatment
-----------------
* Diagnostic Test: Echocardiography
* Diagnostic Test: magnetic resonance imaging
* Diagnostic Test: computed tomography
* Diagnostic Test: blood withdrawl


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients with low to intermediate risk for coronary artery disease Exclusion Criteria: under 18 years mechanical heart valve pulmonary embolism deep vein thrombosis myocardial infarction within the last 3 months electrical cardioversion within 30 days status after heart transplant transient ischemic attack (TIA) or stroke within last 30 days intracerebral bleeding within the last 2 months acute infection existing or planned pregnancy chronic kidney disease with eGFR < 40 ml/min

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: Echocardiography|Patients are undergoing echocardiography|
|Diagnostic Test: magnetic resonance imaging|Patients are undergoing magnetic resonance imaging|
|Diagnostic Test: computed tomography|Patients are undergoing computed tomography|
|Diagnostic Test: blood withdrawl|Peripheral blood samples are being collected from all patients|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Biomarker levels before cardiac imaging |  | 24 hours before cardiac imaging |
Scape Room With High Fidelity Simulators

Study Overview
=================
Brief Summary
-----------------
The objective of the present study is assess the efficcacy in the acquisition of knowledge and practical skills of a scape room with high definition simulators. An experimental trial will be carried out in which the students of the intervention group will receive practical training on newborn care in the delivery room through the development of a scape room with high-fidelity simulators. The control group students will receive practical training only with the use of high-fidelity simulators. The participants of both groups will previously receive a theoretical training of 10 hours. Knowledge acquisition and student satisfaction with both methodologies will be analyzed.

Official Title
-----------------
Scape Room With High Fidelity Simulator: Results in the Learning and Satisfaction of Nursing Degree Students

Conditions
-----------------
Nursing Education

Intervention / Treatment
-----------------
* Other: Scape Room
* Other: Simulation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Nursing degree students of University of Extremadura Exclusion Criteria: 1st year nursing degree students Nursing degree students of other universities

Ages Eligible for Study
-----------------
Minimum Age: 19 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Scape room<br> | Other: Scape Room<br>* Practical training through scape-room with simulator<br>|
| Active Comparator: Simulation<br> | Other: Simulation<br>* Practical training through simulator<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Knowledge test | The degree of knowledge and skills related to the care of the newborn will be measured by means of an evaluation questionnaire that will consist of 20 multiple choice questions.. | 1 month after training session | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Satisfaction likert scale | the degree of student satisfaction with the methodology used will be evaluated with a 6-item likert scale | 1 month after training session |
Probiotics in Radiation-treated Gynecologic Cancer

Study Overview
=================
Brief Summary
-----------------
The aim of the current Project is to study the efficacy of a probiotic Product in reducing the symptoms of gastrointestinal toxicity linked to the irradiation of gynecologic cancer.

Official Title
-----------------
Probiotics in Radiation-treated Gynecologic Cancer

Conditions
-----------------
Gastrointestinal Toxicity, Gynecologic Cancer

Intervention / Treatment
-----------------
* Dietary Supplement: Capsules placebo
* Dietary Supplement: Capsules probiotic powder and corn starch


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Women diagnosed with cancer in the small pelvis and waiting to receive radiotherapy either as a primary or as a secondary treatment following surgery. Chemotherapy may or may not be part of the treatment regimen. Age, older than 18 years old. Agreement for participation in the study by signed written informed consent. Exclusion Criteria: Previously treated with irradiation of the pelvic area. Reluctance to refrain from using other probiotic products during the participation in the study.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Placebo<br>capsules containing corn starch | Dietary Supplement: Capsules placebo<br>* Capsules<br>|
| Active Comparator: Probiotic low dose<br>capsules containing probiotic powder and corn starch | Dietary Supplement: Capsules probiotic powder and corn starch<br> <br> |
| Active Comparator: Probiotic high dose<br>capsules containing probiotic powder and corn starch | Dietary Supplement: Capsules probiotic powder and corn starch<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in incidence of loose/watery stools |  | Baseline and 10 weeks later |
Subclassification of the Syndrome of Inappropriate ADH Secretion

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to evaluate the different types of osmotic dysregulation in patients with Syndrome of Inappropriate ADH (SIADH) and, hence, to analyze the pathophysiology of SIADH. These types will be characterized by measurement of AVP and copeptin while performing an osmotic stimulation with infusion of hypertonic saline.

Official Title
-----------------
Subclassification of the Syndrome of Inappropriate Antidiuresis Via Copeptin - What is the Genesis of ADH-independent SIADH?

Conditions
-----------------
Hyponatremia

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age > 18 years, hyponatremia < 132 mmol/L SIADH Exclusion Criteria: age < 18 years cerebral metastases serum sodium > 132mmol/L

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
hyponatremia, SIADH, copeptin
Postoperative Respiratory Depression After Cardiac Surgery

Study Overview
=================
Brief Summary
-----------------
Coronary artery bypass graft surgery (CABG) is associated with postoperative respiratory depression. In this study we aimed at investigating perioperative parameters that could predict the nadir of postoperative respiratory function impairment.

Detailed Description
-----------------
Coronary artery bypass graft (CABG) surgery is a principal revascularization option for ischemic heart disease and the principal modality for invasive treatment of coronary artery disease. Postoperative pulmonary complications are the most frequent and significant contributor to length of hospitalization, morbidity and mortality. The objective of this study is to search for perioperative parameters that could predict the degree of impairment of respiratory function after CABG with cardiopulmonary bypass (CPB).

Official Title
-----------------
Perioperative Parameters to Predict Postoperative Respiratory Depression After Cardiac Surgery

Conditions
-----------------
Coronary Artery Disease

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients of both sexes older than 18 years submitted to CABG with CPB, presence of coronary disease confirmed by coronary angiography, use of the left internal thoracic artery and/or saphena, patients who remained in spontaneous ventilation on the first postoperative day, absence of chronic or acute pulmonary disease, and giving written informed consent to participate in the study. Exclusion Criteria: intraoperative change of the surgical technique, surgical complications or complications occurring in the ICU, emergency reoperation, renal failure, failure to agree to continue in the study, presence of other types of heart disease, and presence of pulmonary diseases.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative Respiratory Depression After Cardiac Surgery | Respiratory function is assessed through maximal inspiratory (MIP) and expiratory (MEP) pressures and peak expiratory flow (PEF) determined 1 day before surgery and one postoperative week. | 9 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Intraoperative parameters after coronary artery bypass graft surgery (CABG) | Intraoperative parameters are monitored, including volume of cardioplegia, CPB duration, aortic cross-clamp time, number of grafts. | 1 day | 
| Perioperative parameters after coronary artery bypass graft surgery (CABG) | ICU blood pressure is monitored | 3 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
ICU, coronary artery bypass surgery, cardiopulmonary bypass, postoperative respiratory depression
Basic Sensations Coming From the Bladder

Study Overview
=================
Brief Summary
-----------------
A major complication in studies to identify the nature of bladder sensations is language. It is difficult, if not near impossible, for the lay person, with no knowledge of physiology, anatomy or pathology, to put into simple terms a description of basic visceral sensations. Therefore, before the investigators can speculate about the detailed mechanisms generating sensation the investigators must overcome this language and communication difficulty. This will be addressed in the present study. There are important reasons why the investigators must identify the mechanisms generating the different sensations as the bladder fills. One of them is that these are basic physiological mechanisms which need to be better understood.

Official Title
-----------------
Description of Basic Visceral Sensations Coming From the Bladder

Conditions
-----------------
Healthy, Overactive Bladder Syndrome

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy volunteers Healthy students from The University of Maastricht well versed in Dutch. Patients Patients with OAB diagnosed by their urologist using the criteria of more than 8 micturitions on three consecutive days. Before the start of any anticholinergic or other therapy. Patients on anticholinergic therapy will be asked to stop this therapy for at least 10 days before they enter the first session. Well versed in Dutch. Exclusion Criteria: Healthy volunteers Use of any medication (except oral contraceptives) Surgical history of the abdomen Urinary complaints (e.g. frequency, urgency) Urinary tract infection Patients: Congestive heart disease or history of heart failure Presence of urinary tract infection. These patients will be treated by antibiotics.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients<br>Patients with overactive bladder syndrome | |
| Healthy volunteers<br>Healthy volunteers | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| description of bladder sensations | The primary objective of this experiment is to address how medical students and patients with OAB describe the sensations they feel during the filling phase of the bladder. Primary objectives To put into simple terms a description of basic visceral sensations coming from the bladder Describe the pattern of normal sensations during filling |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
focus groups, overactive bladder, bladder sensations
Wide Awake Local Anesthesia No Tourniquet

Study Overview
=================
Brief Summary
-----------------
The main objective is to assess patient's satisfaction regarding pure local anaesthesia and without use of a tourniquet (WALANT Technique) for trigger finger release surgery.

Official Title
-----------------
Wide Awake Local Anesthesia No Tourniquet

Conditions
-----------------
Trigger Finger Disorder

Intervention / Treatment
-----------------
* Procedure: WALANT Technique


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients of age Isolated Trigger finger, diagnosis confirmed by sonography and with indication of surgical release Patients protected by health insurance Patients who have received proper information on the current research proctol, and did not refuse to enter the study Exclusion Criteria: Hand vascular disorders ( History of finger replantation surgery, clinical signs of poor hand vascularization Hypersensitivy to Xylocain or Adrenalin or one of it's components Other surgical act planned to be performed during the same anaesthesia Pregnant or Breastfeeding women Patients of age and under the protection of a conservator, patients deprived of liberty

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: WALANT Technique|pure local anaesthesia and without use of a tourniquet (WALANT Technique) for trigger finger release surger|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patient satisfaction | Patient's agreement to use WALANT for possible surgeries to come and Patient's agreement to refer WALANT to his close relatives if they were to undergo surgery | one day after surgery |