Therapeutic Efficacy of Categorical Language Fluency Smartphone Game Application

Study Overview
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Brief Summary
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The purpose of this study is to examine therapeutic efficacy of categorical language fluency smartphone game application in mild cognitive impairment and mild Alzheimer's dementia.

Detailed Description
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The Categorical Language Fluency Smartphone Game Application was developed based on the semantic distance training, which was effective in improving categorical language fluency of mild cognitive impairment and mild Alzheimer's dementia. 10 patients with mild cognitive impairment and another 10 patients with mild Alzheimer's dementia were recruited to examine therapeutic efficacy of the application.

Official Title
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A Study of Therapeutic Efficacy of Categorical Language Fluency Smartphone Game Application in Mild Cognitive Impairment and Mild Alzheimer's Dementia (Baseline Study)

Conditions
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Mild Cognitive Impairment, Alzheimer's Disease

Intervention / Treatment
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* Device: Categorical Language Fluency Smartphone Application


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Aged above 55 Confirmed literacy Diagnosed to mild cognitive impairment by International Working Group on Mild Cognitive Impairment and Clinical Dementia Rating(CDR) of 0 or 0.5. Diagnosed to possible or probable Alzheimer's dementia by NINCDS-ADRDA and Clinical Dementia Rating(CDR) of 1 or below. Exclusion Criteria: Evidence of delirium, confusion Any neurological conditions causing cognitive decline such as Parkinson's disease, brain hemorrhage, brain tumor, normal pressure hydrocephalus Evidence of severe cerebrovascular pathology History of loss-of-consciousness over 1 hour due to head trauma or repetitive head trauma of mild severity History of substance abuse or dependence such as alcohol Presence of depressive symptoms that could influence cognitive function Presence of medical comorbidities that could result in cognitive decline

Ages Eligible for Study
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Minimum Age: 55 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Categorical Language Fluency Smartphone Application<br>Smartphone game application specifically aimed at training categorical language fluency | Device: Categorical Language Fluency Smartphone Application<br>* 4 weeks' training<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Application usage log | Log to assess compliance of participant(by describing frequency and duration of training by using application) | 4-weeks treatment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Subjective Memory Complaint Questionnaire | to evaluate efficacy of application | after 4-weeks treatment | 
| Geriatric Depression Scale | to evaluate efficacy of application | after 4-weeks treatment | 
| Korean version of MMSE for dementia screening | to evaluate efficacy of application | after 4-weeks treatment | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Mild cognitive impairment, Cognitive rehabilitation, Cognitive therapy, Alzheimer's disease, Memory enhancement, Categorical language fluency