Functional Magnetic Resonance Imaging (fMRI) Studies in Pathological Gambling (PG) and Obsessive-Compulsive Disorder (OCD)

Study Overview
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Brief Summary
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This study will explore the brain processes associated with inhibition and reward processing in pathological gamblers and people with obsessive compulsive disorder compared to healthy controls.

Detailed Description
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This study will explore the brain processes associated with inhibition and reward processing in pathological gamblers and people with obsessive compulsive disorder compared to healthy controls. Healthy participants and participants who are diagnosed with PG or OCD will undergo one fMRI scan. The brain scan will last about one and a half hours and will involve performing tasks while in the scanner.

Official Title
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fMRI Studies in Pathological Gambling and Obsessive-Compulsive Disorder

Conditions
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Pathological Gambling, Obsessive Compulsive Disorder

Intervention / Treatment
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* Procedure: fMRI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Male or female adults diagnosed with pathological gambling or obsessive compulsive disorder aged 18-55. Subject has signed an informed consent form Must provide contact information Must be in generally good health Must be willing and able to read written instructions and complete scales Must be English speaking In the opinion of the investigator, the subject is capable of complying with all study procedures Pathological Gamblers only: Current diagnosis of pathological gambling, supported by DSM-IV SCI-PG Must score ≥ 5 on SOGS Must score ≥ 2 on item number 1 on the G-SAS Subjects must have a severity score of ≥ 4 (moderately ill) on the Clinical Global Impressions Scale - Severity (CGI-S) Must score ≥ 10 on questions 1-5 on PG-Y-BOCS Must score ≤ 15 on YMRS Must have gambled once within past 2 weeks of Screening Visit. Exclusion Criteria: Subjects with a primary diagnosis of schizophrenia, personality disorder, or other psychotic disorders Subjects with a primary diagnosis of an Axis I disorder that may require intervention Must not score >24 on the Montgomery-Asberg Depression Rating Scale (MADRS) (pathological gamblers only) Subjects who live in a restrictive environment Subjects with a current DSM-IV diagnosis of substance dependence or abuse, excluding nicotine Subjects reporting a history of drug and/or alcohol dependence or abuse; subjects who report occasional drug use in the past will be discussed by a panel (consisting of Dr. Gilbert, Dr. Fan and Dr. Bartz), and will be considered for participation on a case by case basis Subjects who have used psychotropic medications in the past week to six weeks (depending on the medication) Subject has a positive drug urine screen Female subjects who are pregnant Subjects who report a history of severe liver, heart, or kidney disease because these conditions are associated with neurological sequella Employees of the investigator or study center or their families Finally, subjects who do not satisfy the following criteria will be excluded because they will be unable to undergo the MRI procedure. Specifically, subjects will be excluded who have: a pacemaker any implanted metallic chips in their head ever worked around a metal lathe or had a shrapnel (war or gun shot) wound/injury an implanted neuro-stimulatory or infusion/insulin pump any devices placed in their blood vessels any metal in/on their body kidney disease sickle-cell or hemolytic anemia claustrophobia any metallic tattoos any body piercing that cannot be removed dental braces any permanent make-up any cardiac stints

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Pathologic Gamblers<br> | Procedure: fMRI<br>* fMRI<br>|
| Obsessive Compulsive Disorder<br> | Procedure: fMRI<br>* fMRI<br>|
| Healthy Controls<br> | Procedure: fMRI<br>* fMRI<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| fMRI - go-nogo task | a measure of behavioral response inhibition | at baseline | 
| fMRI - monetary incentive delay (MID) task | a measure of neural response to anticipating and receiving monetary rewards | at baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Pathological Gambling, Obsessive-Compulsive Disorder, Go No-go, Monetary incentives delay, fMRI