Defining the Sympathetic Skin Response of Migraineurs in the Facial Area

Study Overview
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Brief Summary
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The aim of this study is to define the sympathetic skin response of migraineurs in the facial area. This will be achieved by exposing healthy volunteers and migraine patients to various stress stimuli (pain, visual stimulation, auditory stimulation and a mathematical challenge), and recording sympathetic skin response in the facial area.

Official Title
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Defining the Sympathetic Skin Response of Migraineurs in the Facial Area During the Interictal State: Comparison of Migraine Patients Who Suffer Dominant Left/Right/Bilateral Pain.

Conditions
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Migraine Disorders

Intervention / Treatment
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* Other: Pain stimulation
* Other: Visual stimulation
* Other: Auditory stimulation
* Other: Mental stress


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy volunteers with no history of any kind of recurrent headache Migraine patients according to ICH3 criteria Migraine patients with more than 1 attack per month Exclusion Criteria: Patients with other heart or neurologic diseases Patients with hearing or visual decline Patients taking medication that effects the sympathetic system (except those taking beta blockers for migraine treatment)

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Healthy volunteers<br>Healthy volunteers will be exposed to pain stimulation, visual stimulation, auditory stimulation and mental stress | Other: Pain stimulation<br>* Pain will be simulated with an electric shock 25 mlAMP over the median nerve<br>Other: Visual stimulation<br>* Visual stimulation will be performed by a flicker of light on a computer screen at 15 Hrz for 0.3 seconds<br>Other: Auditory stimulation<br>* Auditory stimulation will be delivered through headphones with a sound at 500 Hrz at 85 decibels for 0.3 seconds<br>Other: Mental stress<br>* A mathematical challenge will be displayed on a computer screen that must be quickly solved<br>|
| Left headache<br>Migraine patients with mostly left sided headache will be exposed to pain stimulation, visual stimulation, auditory stimulation and mental stress | Other: Pain stimulation<br>* Pain will be simulated with an electric shock 25 mlAMP over the median nerve<br>Other: Visual stimulation<br>* Visual stimulation will be performed by a flicker of light on a computer screen at 15 Hrz for 0.3 seconds<br>Other: Auditory stimulation<br>* Auditory stimulation will be delivered through headphones with a sound at 500 Hrz at 85 decibels for 0.3 seconds<br>Other: Mental stress<br>* A mathematical challenge will be displayed on a computer screen that must be quickly solved<br>|
| Right headache<br>Migraine patients with mostly right sided headache will be exposed to pain stimulation, visual stimulation, auditory stimulation and mental stress | Other: Pain stimulation<br>* Pain will be simulated with an electric shock 25 mlAMP over the median nerve<br>Other: Visual stimulation<br>* Visual stimulation will be performed by a flicker of light on a computer screen at 15 Hrz for 0.3 seconds<br>Other: Auditory stimulation<br>* Auditory stimulation will be delivered through headphones with a sound at 500 Hrz at 85 decibels for 0.3 seconds<br>Other: Mental stress<br>* A mathematical challenge will be displayed on a computer screen that must be quickly solved<br>|
| Bilateral headache<br>Migraine patients without a dominant side headache will be exposed to pain stimulation, visual stimulation, auditory stimulation and mental stress | Other: Pain stimulation<br>* Pain will be simulated with an electric shock 25 mlAMP over the median nerve<br>Other: Visual stimulation<br>* Visual stimulation will be performed by a flicker of light on a computer screen at 15 Hrz for 0.3 seconds<br>Other: Auditory stimulation<br>* Auditory stimulation will be delivered through headphones with a sound at 500 Hrz at 85 decibels for 0.3 seconds<br>Other: Mental stress<br>* A mathematical challenge will be displayed on a computer screen that must be quickly solved<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Defining sympathetic skin response in migraineurs | Outcome will be presented as mean sympathetic response values for all the different stimuli and then separately for each stimuli | One year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Defining differences between sympathetic skin response in migraineurs | Outcome will be presented as mean sympathetic response values for all the different stimuli and then separately for each stimuli | One year |