Temsirolimus, Bendamustine and Rituximab for Relapsed Follicular Lymphoma or Mantle Cell Lymphoma

Study Overview
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Brief Summary
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This is a multicenter, open label, single arm, phase I/II study. There will be no placebo usage within this trial. Phase I: Primary: To establish a maximum tolerated dose of the addition of Temsirolimus to a regimen of Bendamustine and Rituximab (BERT) in patients with relapsed follicular lymphoma and mantle cell lymphoma. Phase II: Primary: To evaluate the ORR in patients with MCL or FL treated with the established BERT dose Secondary: To determine the complete remission rate, progression free survival rate and overall survival rate and to investigate safety and tolerability of BERT.

Detailed Description
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The first part of the study is a phase I study in which the maximum tolerated dose of the combination of Temsirolimus, Bendamustine and Rituximab will be established. In the phase I part of the trial 3 patients will be included in each dose level. After inclusion of 3 patients, each patient has to receive at least 2 complete cycles without DLT until the enrolment into the next cohort can be initiated. In case of one DLT, 3 additional patients will be added to the specific dose level. If a second DLT appears, the last dose level without DLT will be considered the standard dose for the phase II trial. If the third dose level is achieved without any DLT, there will be no further dose escalation. In the phase II proportion of the trial, after establishment of a maximum tolerated dose, the efficacy of the combination regimens in two different patient cohorts will be evaluated. In the one cohort, 30 patients with relapsed mantle cell lymphoma will be treated; the second cohort will be composed of 30 patients with relapsed follicular lymphoma.

Official Title
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A Phase I/II Trial to Evaluate the Safety, Feasibility and Efficacy of the Addition of Temsirolimus to a Regimen of Bendamustine and Rituximab for the Treatment of Patients With Follicular Lymphoma or Mantle Cell Lymphoma in First to Third Relapse

Conditions
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Follicular Lymphoma, Mantle Cell Lymphoma

Intervention / Treatment
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* Drug: Temsirolimus, Rituximab, Bendamustin


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Histologically proven diagnosis of follicular non-Hodgkin's lymphoma grades l, II or IIIA or mantle cell lymphoma (including Cyclin D1 expression) according to the World Health Organization classification Documented relapse or progression following at least one but not more than 3 antineoplastic treatments At least 1 measurable tumor mass (>1.5 cm x >1.0 cm) or bone marrow infiltration Subjects 18 years or older Status post. high dose therapy or no transplantation option available or patient refuses an aggressive treatment strategy Subjects (or their legally acceptable representatives) must have signed an informed consent document indicating that they understand the purpose of and procedures required for the study and are willing to participate in the study Adequate bone marrow reserve: Platelets of at least 75000/µl, absolute neutrophil count at least 1500/µl. In case of extensive bone marrow infiltration and lower platelet or absolute neutrophil counts, patients can not be included in the phase I part of the trial. In the phase II proportion of the trial patients may be included with a platelet count of more or equal to 50000/µl on the discretion of the investigator, if thrombocytopenia is associated with massive bone marrow infiltration. Adequate hepatic and renal function Alanine aminotransferase <2.5 x upper limit of normal (ULN); Aspartate aminotransferase <2.5 x ULN, Total bilirubin <1.5 x ULN Measured or calculated creatinine clearance >50 mL/min Eastern Cooperative Oncology Group [ECOG] performance Status 0-2 Female subject must be postmenopausal (for at least 6 months), surgically sterile, abstinent, or, if sexually active, be practicing an effective method of birth control (e.g., prescription oral contraceptives, contraceptive injections, intrauterine device, double-barrier method, contraceptive patch, male partner sterilization) before entry and throughout the study; and have a negative serum ß-hCG pregnancy test at screening Exclusion Criteria: Lymphoma other than MCL or FL Active central nervous System lymphoma. Brain MRI is required only if clinically indicated Pregnancy or breast feeding women Severe concomitant disease (e.g. uncontrolled arterial hypertension, heart failure (NYHA III-IV), uncontrolled diabetes mellitus, pulmonary fibrosis, uncontrolled hyperlipoproteinemia) Active uncontrolled infections including HIV-positivity, active Hep B or C Mental status precluding patient's compliance Comedication with strong CYP 3A4/5-inhibitors or -inducers (Appendix 22.7) Prior treatment with Temsirolimus Known CD20 negativity Patients refractory to Bendamustine in a prior treatment line, defined as relapse within 1 year after initiation of first cycle. Exception: termination of treatment prior to third scheduled cycle for reasons other than toxicity. Status post allogeneic transplantation Peripheral neuropathy or neuropathic pain of Grade 2 or worse Diagnosed or treated for a malignancy other than NHL except: adequately treated non-melanoma skin cancer, curatively treated in-situ cancer of the cervix, DCIS of the breast, or other solid tumors curatively treated with no evidence of disease for >5 years Concurrent treatment with another investigational agent. Concurrent participation in non-treatment studies is not excluded. Known intolerance to sirolimus or derivates, or Bendamustine or Rituximab.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Single arm<br>Bendamustin, Rituximab, Temsirolimus | Drug: Temsirolimus, Rituximab, Bendamustin<br>* Phase I: Temsirolimus 25 - 50 - 75mg, day 1,8,15 Bendamustin 90/m2, day 1,2 Rituximab 375/m2, day 1 Phase II at established dose, repeat day 28-42 (max)<br>* Other names: Mabthera, Rituxan, Torisel, Bendamustin, Ribomustin, Trenda;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Phase I: MTD / Phase II: ORR | phase II: ORR is evaluated approx. 6 weeks after end of treatment | Phase I: 2 months (start cycle 3), Phase II: 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Progression free survival | for part II only | at 2 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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temsirolimus, bendamustine, rituximab, mantle cell lymphoma, follicular lymphoma