Long-term Surgical Treatment Outcome of Peri-implantitis Lesions

Study Overview
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Brief Summary
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The surgical treatment outcome of patients that have been or are consecutively treated at the Specialist Clinic, Department of Periodontology, University of Malmö, will be evaluated on an a regular base; specifically all patients treated since 2014 and those receiving treatment in the future, will be regularly assessed, max. once per year after the 1-year control from the surgical intervention for clinical and radiographic assessment of healing. Clinical peri-implant parameters (e.g., probing pocket depth) and peri-implant sulcus fluid (PISF) are collected, and a peri-apical radiographic examination is made. Further, from 50 patients treated in the future, the inflammatory peri-implant lesion will be collected and subjected to histological, microbiological, and molecular analysis. The removal of these lesions is a standard procedure and performed in all patients independent of study participation; i.e., the lesion has anyway to be removed during surgery and if the lesions are not stored, they would be thrown.

Official Title
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Long-term Surgical Treatment Outcome of Peri-implantitis Lesions

Conditions
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Peri-Implantitis

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All patients being treated since 2014 and continuously being treated in the next 3 years will be called in for regular check-ups after the surgical intervention and an examination for study purpose will be performed annually. Exclusion criteria: - implant loss

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 130 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Disease resolution (Binary: yes/no) | Disease resolution will be defined as peri-implant probing pocket depth ≤ 5 mm and no excessive bleeding and/or suppuration on probing. | 12 months postoperative | 
| Disease resolution (Binary: yes/no) | Disease resolution will be defined as peri-implant probing pocket depth ≤ 5 mm and no excessive bleeding and/or suppuration on probing. | 24 months postoperative | 
| Disease resolution (Binary: yes/no) | Disease resolution will be defined as peri-implant probing pocket depth ≤ 5 mm and no excessive bleeding and/or suppuration on probing. | 36 months postoperative | 
| Disease resolution (Binary: yes/no) | Disease resolution will be defined as peri-implant probing pocket depth ≤ 5 mm and no excessive bleeding and/or suppuration on probing. | 48 months postoperative | 
| Disease resolution (Binary: yes/no) | Disease resolution will be defined as peri-implant probing pocket depth ≤ 5 mm and no excessive bleeding and/or suppuration on probing. | 60 months postoperative | 
| Disease resolution (Binary: yes/no) | Disease resolution will be defined as peri-implant probing pocket depth ≤ 5 mm and no excessive bleeding and/or suppuration on probing. | 72 months postoperative | 
| Disease resolution (Binary: yes/no) | Disease resolution will be defined as peri-implant probing pocket depth ≤ 5 mm and no excessive bleeding and/or suppuration on probing. | 84 months postoperative | 
| Disease resolution (Binary: yes/no) | Disease resolution will be defined as peri-implant probing pocket depth ≤ 5 mm and no excessive bleeding and/or suppuration on probing. | 96 months postoperative | 
| Disease resolution (Binary: yes/no) | Disease resolution will be defined as peri-implant probing pocket depth ≤ 5 mm and no excessive bleeding and/or suppuration on probing. | 108 months postoperative | 
| Disease resolution (Binary: yes/no) | Disease resolution will be defined as peri-implant probing pocket depth ≤ 5 mm and no excessive bleeding and/or suppuration on probing. | 120 months postoperative |