Self and Autobiographical Memory in Dementia With Lewy Bodies and Alzheimer Disease: a Behavioral and Multimodal Neuroimaging Study

Study Overview
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Brief Summary
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The present project aims at exploring different components of Self-consciousness or 'the Self', such as autobiographical memory, self-concept and subjective sense of Self, in dementia with Lewy Bodies (DLB) compared to Alzheimer's disease and to normal ageing. Anatomical substrates will be studied in multimodal imaging, in terms of volume, anatomical and functional connectivity. We expect to find an alteration of the different components of the Self, consecutive to insular dysfunction, a key region within cerebral networks of self-consciousness, which is damaged early in the course of the disease.

Official Title
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Self in Dementia With Lewy Bodies: a Behavioral and Multimodal Neuroimaging Study

Conditions
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Dementia With Lewy Bodies, Alzheimer Disease, Self, Autobiographical Memory, Insular Cortex

Intervention / Treatment
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* Other: Neuropsychological assessment and Multimodal brain MRI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Inclusion criteria for all participants: Male or female aged between 60 to 80, at the inclusion visit Right-handed Must be affiliated to a social health insurance protection scheme Must be able both to understand the objectives and risks related to the study and to give a dated and signed informed consent Fluency in French At least 9 years of formal education Inclusion criteria for group of dementia with Lewy bodies: Subject meeting McKeith et al. criteria (2017) Subject with prodromal dementia with Lewy bodies meeting the DSM-V Mild Cognitive Impairment criteria (2013) Subject with prodromal or mild dementia with Lewy bodies with an ≤ 20 MMSE score Availability of a caregiver for the inclusion visit Inclusion criteria for group of Alzheimer disease: Subject meeting Dubois et al. criteria (2014) Subject with prodromal or mild Alzheimer disease with an ≤ 20 MMSE score Availability of a caregiver for the inclusion visit Inclusion criteria for healthy elderly: Subject must be matched with patients in terms of age, gender and educational level Absence of any cognitive complaint Autonomy must be preserved Exclusion Criteria: Subjects with significant neuropsychiatric comorbidities Abnormal neurological examination Sensory impairment that may significantly interfere with testing Contraindication to MRI Claustrophobia Heavy psychotropic drug treatment Excessive and regular consumption of alcohol Subject in period of exclusion (determined by a previous or ongoing study) Inability to give the subject informed information Subject under judicial protection Subject under tutorship or guardianship

Ages Eligible for Study
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Minimum Age: 60 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: dementia with Lewy bodies<br> | Other: Neuropsychological assessment and Multimodal brain MRI<br>* Neuropsychological assessment and Multimodal brain MRI<br>|
| Active Comparator: Alzheimer disease<br> | Other: Neuropsychological assessment and Multimodal brain MRI<br>* Neuropsychological assessment and Multimodal brain MRI<br>|
| Sham Comparator: healthy elderly subjects<br> | Other: Neuropsychological assessment and Multimodal brain MRI<br>* Neuropsychological assessment and Multimodal brain MRI<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Neuropsychological assessment |  | months 3 | 
| Multimodal brain MRI |  | months 3 |