linjc16/ctgov huggingface dataset:
Exercise-induced High-sensitivity Troponin Levels as a Predictor for Obstructive Coronary Artery Disease

Study Overview
=================
Brief Summary
-----------------
To compare hs-TnT levels after a cardiac stress test in patients with vs. patients without CAD To assess the level of post-exercise hs-TnT predicting CAD (using ROC-analysis) To determine the sensitivity, specificity and accuracy of this exercise-induced hsTopT level in predicting CAD, either alone or in relation to traditional patient-related and exercise test-related metrics

Official Title
-----------------
Exercise-induced High-sensitivity Troponin Levels as a Predictor for Obstructive Coronary Artery Disease

Conditions
-----------------
Coronary Artery Disease

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with suspected CAD, planned for diagnostic coronary angiogram Patients with previous revascularization, suspected of recurrent ischemia Exclusion Criteria: Congestive cardiomyopathy with LV EF < 35% Renal failure with eGFR < 30 ml/min Known structural or severe valvular heart disease Prior CABG Previous ACS < 6 weeks Known incomplete revascularization after previous PCI Unstable angina or ACS (defined as unstable anginal symptoms + ECG changes or hs-TnT > 0.053 ng/L)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 99 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| patients with hemodynamic significant CAD;<br> | |
| patients without hemodynamic significant CAD<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Presence of coronary artery stenosis more than 50% |  | 24 hours | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
exercise test, HS -troponin, Coronary artery disease
Intramuscular Injections of Botulinum Toxin in Lateral Pterygoid Muscle in the Treatment of Temporomandibular Dysfunctions: Studying the Interest of MRI Guidance and Ultrasound Guidance

Study Overview
=================
Brief Summary
-----------------
The main hypothesis is that a significant pain improve (measured with Visual Analogic Scale [VAS]) can be observed after injection of botulinum toxin A, meaning the success of the guidance device.

Official Title
-----------------
Intramuscular Injections of Botulinum Toxin in Lateral Pterygoid Muscle in the Treatment of Temporomandibular Dysfunctions: Studying the Interest of MRI Guidance and Ultrasound Guidance

Conditions
-----------------
Mandibular Dysfunction

Intervention / Treatment
-----------------
* Device: MRI guidance
* Device: Ultrasound guidance


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients suffering from muscular TemporoMandibular Dysfunctions (TMD) with clinical diagnosis: myofascial pain, limited opening of the mouth, articular noise. >= 18 years old with signed informed consent form Exclusion Criteria: articular TMD: arthritis or other inflammatory disease of temporomandibular joint, arthrosis, bone deformation, previous fracture of condylar area ; electromyographic hypoactivity, pure muscular diseases ; oro-mandibular dystonia ; botulinum toxin allergy, risk of bleeding recent or active infection intercurrent antibiotic treatment (drug interaction) ; vaccination during the 15 days preceding the injection.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: MRI guidance<br>Injections of botulinum toxin performed using MRI guidance | Device: MRI guidance<br>* Injections of botulinum toxin performed using MRI guidance<br>|
| Experimental: Ultrasound guidance<br>Injections of botulinum toxin performed using ultrasound guidance | Device: Ultrasound guidance<br>* Injections of botulinum toxin performed using ultrasound guidance<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain improvement | Significant improvement of the pain measured with VAS (0 to 10), corresponding to at least 30% decrease of the pain after injection of botulinum toxin A | Month 2 |
The Effect of Non Invasive Electrical Stimulation Therapy on Gastroesophageal Reflux Disease (GERD) Symptoms - Proof of Concept Study

Study Overview
=================
Brief Summary
-----------------
The aims of the study: To evaluate whether the use of a specific TENS technology can improve GERD symptoms and esophageal acid exposure.

Official Title
-----------------
The Effect of Non Invasive Electrical Stimulation Therapy on Gastroesophageal Reflux Disease (GERD) Symptoms - Proof of Concept Study

Conditions
-----------------
Gastroesophageal Reflux Disease

Intervention / Treatment
-----------------
* Device: TENS


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: at least 3 episodes of heartburn and/or regurgitation in a week for at least 3 months. evidence for an abnormal esophagal acid exposure on impedance-pH monitoring (tested in the last 2 years off PPI) Exclusion Criteria: gastric or esophagal surgery active peptic ulcer disease malignancy pregnancy uncontrolled diabetes mellitus severe cardiac conditions such as cardiac arrhythmia or ischemia or cardiac pacemaker/defibrillator allergy to adhesives/patches severe pulmonary disease obesity (BMI>30)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Protocol #1<br>interventions: 1.6Hz, Rampdown 0.4S, electrodes position - both L.Rectus Abdominis, 5cmX5cm Size, on inspirium | Device: TENS<br> <br> |
| Active Comparator: Protocol #2<br>1Hz, Rampdown 0.6S, electrodes position - both Rectus Abdominis, 5cmX5cm Size, on inspirium | Device: TENS<br> <br> |
| Active Comparator: Protocol #3<br>1.6Hz, Rampdown 0.4S, electrodes position - L.Rectus Abdominis and L.External Oblique, 5cmX5cm Size, on inspirium Oblique | Device: TENS<br> <br> |
| Active Comparator: Protocol #4<br>1Hz, Rampdown 0.6S, electrodes position - L.Rectus Abdominis and L.External Oblique, 5cmX5cm Size, on inspirium | Device: TENS<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Symptoms severity questionnaire (heartburn and regurgitation) before and after treatment |  | 34 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Esophageal acid exposure before and after treatment | Ph monitoring | 34 days |
Ocular Pharmacokinetics After a Single Drop Instillation of T1225 0.5, 1, 1.5% in 91 Healthy Volunteers

Study Overview
=================
Brief Summary
-----------------
To evaluate azithromycin tear concentrations after instillation of one drop of one of the three T1225 concentrations (0.5%, 1% and 1.5%) and to evaluate the ocular safety.

Detailed Description
-----------------
The aim of the present study was to compare azithromycin tear ocular concentrations after a single instillation of three different T1225 concentrations in order to determine early azithromycin tear concentration and to assess the T1225 concentration, which allowed having the higher azithromycin tear concentration, 24 hours after a single instillation.

Official Title
-----------------
Ocular Pharmacokinetics After a Single Drop Instillation, in Each Eye of One of Three Different Concentrations of T1225 (0.5% - 1% - 1.5% Dihydrate) in 91 Healthy Volunteers

Conditions
-----------------
Eye Infections, Bacterial

Intervention / Treatment
-----------------
* Drug: Azithromycin


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Male/female aged from 18 to 45 years; Written informed consent; Healthy volunteers without any subjective ocular symptom; Corrected visual acuity >= 6/10; Registered in the national register of healthy volunteers Exclusion Criteria: Ocular trauma, infection or inflammation within the last 3 months; Conjunctival hyperaemia (score >= 2); Folliculo-papillary conjunctivitis (score >= 2); Topical ocular treatment within the last month; Ocular surgery, including LASIK and PRK, within the last 12 months; Other ocular laser within the last 3 months; Zithromax® and Azadose® within the last 3 months; Medication during the study (except: paracetamol, contraceptives

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Azithromycin|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Area Under the Curve from 0 to 24 hours (AUC0-24h) |  |  | 
| Elimination half-life (t1/2) |  |  | 
| Maximum Concentration (Cmax) |  |  | 
| Concentration 24 hours after instillation (C24h) |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Tolerance |  |  |
Clinical and Basic Investigations Into Congenital Disorders of Glycosylation

Study Overview
=================
Brief Summary
-----------------
The purpose of this research is to study the natural history of congenital disorders of glycosylation and its causes and treatments.

Detailed Description
-----------------
The investigators are conducting a natural history study of patients with congenital disorders of glycosylation (CDG). The study will look into the progression of the disease amongst the participants and also look at the clinical symptoms and how they vary amongst different diseased population groups. The participants will be asked to fill out questionnaires either on their own or with a provider that will grade the severity of disease and document symptoms and diet. Participants will have an opportunity to submit blood, urine, and stool samples that will be tested for biomarkers for CDG. Participants will also complete dietary food records, physical exams, CDG scores, and the PROMIS questionnaires to assess disease progression and severity.

Official Title
-----------------
Clinical and Basic Investigations Into Congenital Disorders of Glycosylation

Conditions
-----------------
Congenital Disorders of Glycosylation

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients diagnosed with congenital disorders of glycosylation based on genetic confirmatory testing Exclusion Criteria: Patients without congenital disorders of glycosylation
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Indicators of Disease Severity and Progression - organ system involvement | Establish the prevalence and severity of specific morbid indicators of disease severity through use of the Nijmegen Progression CDG rating scale. | Length of study, up to 5 years | 
| Indicators of Disease Severity and Progression - degree of cognitive disability | Establish the prevalence and severity of specific morbid indicators of disease severity through use of the Nijmegen Progression CDG rating scale. | Length of study, up to 5 years | 
| Indicators of Disease Severity and Progression - case-fatality | Establish the prevalence and severity of specific morbid indicators of disease severity through use of the Nijmegen Progression CDG rating scale. | Length of study, up to 5 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
MPI, CDG, CDDG, Congenital Disorders of Glycosylation, Congenital Disorders of Deglycosylation, ALG1, ALG3, ALG6, ALG12, ALG13, COG6, DPAGT1, DPM1, EDEM3, MAN1B1, MPDU1, NGLY1, PGAP3, PGM1, PIGA, PIGG, PIGN, PIGS, PIGT, PMM2, SLC35A2, SLC35C1, SLC39A8, SRD5A3, SSR4, FUT8, GALNT2, MAN2B2, VMA21
Comparability of Hemodynamic Parameters Measured by Non-invasive Echocardiography and by Right Heart Catheterization

Study Overview
=================
Brief Summary
-----------------
This study is to compare transthoracic Echocardiography TTE to the gold standard Right Heart Catheterization in Terms of accuracy to measure hemodynamic parameters.

Detailed Description
-----------------
Chronic heart failure is a progressive disease in Western population. Echocardiography and right heart catheterization are important tools in the diagnosis and progress monitoring of heart failure. Gold standard in diagnosis of hemodynamic parameters in patients with heart failure is right heart catheterization. However, this diagnostic device represents an invasive method that is additionally associated with high risks such as infections, vessel and nerve injuries. Echocardiography is probably in a position to determine hemodynamic parameters as reliably as right heart catheterization without additional health risk due to its non-invasive character. All procedures performed are part of clinical Routine. Patients do not undergo any study-specific procedure at all.

Official Title
-----------------
Comparability of Hemodynamic Parameters Measured by Non-invasive Echocardiography and by Right Heart Catheterization

Conditions
-----------------
Heart Failure

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Chronic heart failure NYHA I - IV Exclusion Criteria: -

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measurement of systolic, diastolic and mean CVP | CVP measured in mmHg | During a single right heart catheterization procedure | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measurement of systolic, diastolic and mean PAP | PAP measured in mmHg | During a single right heart catheterization procedure | 
| Measurement of systolic, diastolic and mean RVP | RVP measured in mmHg | During a single right heart catheterization procedure | 
| Measurement of systolic, diastolic and mean PAWP | PAWP measured in mmHg | During a single right heart catheterization procedure | 
| Measurement of Cardiac Index CI | CI measured in l/M/m² | During a single right heart catheterization procedure | 
| Measurement of Cardiac Output CO | CO measured in l/min | During a single right heart catheterization procedure | 
| Transthoracic Echocardiography | Collected data will be analyzed for comparability | During a single TTE examination | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Echocardiography, Right heart catheterization
Simultaneous Recording of Cognitive and Motor Functions After Stroke

Study Overview
=================
Brief Summary
-----------------
Aim: To assess whether a cognitively demanding dual-task has greater impact on manual dexterity in chronic stroke patients than in healthy subjects. Methods: A visuomotor force-tracking task, combining grip force and oculomotor recordings, will be applied in chronic stroke patients with mild-moderate hemiparesis without clinical cognitive impairments and in age-comparable healthy subjects. The dual-task includes avoiding visual distractors and mental addition of numbers. Dual-task effect is calculated as difference in force control accuracy (dual minus single-task) and as difference in saccade rate (addition of numbers minus visual distractors).

Official Title
-----------------
Simultaneous Recording of Cognitive and Motor Functions After Stroke : Dissociation of Motor and Cognitive Deficits

Conditions
-----------------
Stroke

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: > 18 years old First symptomatic stroke more than 3 months ago Box and blocks test score < 52 Mini Mental State Examination Test > 25 Exclusion Criteria: Psychiatric disease Risk of Pregnancy History of previous stroke Disability that may interfere with the performance of tasks

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Healthy controls<br> | |
| Stroke patients<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Saccade inhibition rate | Cross sectional comparison of % of saccades performed towards visual distractors | Baseline measurement (one occasion) |
A Comparison of Cervical Spine Movement During Tracheal Intubation Using the Pentax or the Glidescope

Study Overview
=================
Brief Summary
-----------------
Both Glide scope and Pentax laryngoscope are video laryngoscope that provide the better view with minimal cervical spine movement. This study wants to compare cervical spine movement during intubation when using these two devices. The C-spine motion will be recorded by using fluoroscopic video to measure the angular displacement of the vertebrae.

Detailed Description
-----------------
The primary outcome is the angular displacement of the vertebrae and secondary outcome is the hemodynamic changes after intubation.

Conditions
-----------------
C-spine Movement During Intubation

Intervention / Treatment
-----------------
* Device: The glidescope video laryngoscopy
* Device: The Pentax airwayscope


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: ASA I-III Age 18-75 years old Elective noncardiac surgery requiring general anesthesia with tracheal intubation Exclusion Criteria: Gastroesophageal reflux disease Body mass index greater than 35 kg/m2 Possibility of pregnancy Previous neck surgery Unstable C-spine/ C-spine abnormality Known difficult airway Suspected difficult airway

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Glide scope<br> | Device: The glidescope video laryngoscopy<br> <br> |
| Experimental: Pentax airway scope<br> | Device: The Pentax airwayscope<br> <br> * Other names: The Pentax airwayscope (Pentax AWS; Pentax, Tokyo, Japan);|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the angular displacement of the vertebrae | during intubation | 30 seconds | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the hemodynamic changes after intubation. | after intubation | 15 minutes | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Glide scope, Pentax, C spine movement
Low Carbohydrate Diet - Effect on Plasma Lipids and Metabolic Markers

Study Overview
=================
Brief Summary
-----------------
Low carbohydrate diet may influence the plasma lipid levels.

Detailed Description
-----------------
Fasting plasma lipids will be measured in healthy volunteer randomized to low carbohydrate diet or usual diet for a period

Official Title
-----------------
Low Carbohydrate Diet - Effect on Plasma Lipids and Metabolic Markers

Conditions
-----------------
Overweight and Obesity, Type IIb Hyperlipidaemia, Hypercholesterolemia Aggravated

Intervention / Treatment
-----------------
* Other: Low carbohydrate dietary advice
* Other: Continue usual diet


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy volunteers Exclusion criteria: Any disease or use of prescriptional medication

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 100 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: LCHF diet<br>Advice of a diet low in carbohydrate | Other: Low carbohydrate dietary advice<br>* Dietary advice<br>* Other names: Dietary advice;Other: Continue usual diet<br>* Dietary advice<br>* Other names: Lifestyle counseling to continue usual diet;|
| Active Comparator: Usual diet<br>Subjects shall continue to eat their usual daily diet with no low carbohydrate intervention | Other: Continue usual diet<br>* Dietary advice<br>* Other names: Lifestyle counseling to continue usual diet;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percent change in mean LDL-cholesterol after intervention with low carbohydrate diet |  | From baseline to study end | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Cardio vascular risk factors