Prognosis in Neurological Intensive Care Unit Patients (proNICU Cohort)

Study Overview
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Brief Summary
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This study examines the prognostic properties of immune parameters, clinical scores, electrophysiological tests (eeg, ssep, emg, eng) and functional imaging for the prediction of functional outcome one year after treatment on a neurological intensive care unit.

Official Title
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Prognosis in Neurological Intensive Care Unit Patients (proNICU Cohort)

Conditions
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Neurological Diseases

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: severe neurological disease making treatment on a neurological intensive care unit necessary age ≥ 18 consent by the patient or the legal representative Exclusion Criteria: participation in an interventional trial

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| severe neurological diseases<br>Patients with severe neurological diseases treated on the neurological intensive care unit | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Predictive properties of immune parameters (IL6, IL10, mHLA-DR) for functional outcome one year after symptom onset | To evaluate of the predictive properties of immune parameters (IL6, IL10, mHLA-DR) for functional outcome one year after symptom onset | one year after symptom onset | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To evaluate of the predictive properties of clinical scores for functional outcome one year after symptom onset | To evaluate of the predictive properties of clinical scores for functional outcome one year after symptom onset | one year after symptom onset | 
| To evaluate of the predictive properties of electrophysiological measurements one year after symptom onset | To evaluate of the predictive properties of electrophysiological measurements one year after symptom onset | one year after symptom onset | 
| To evaluate of the predictive properties of conventional (DTI) and functional imaging (resting state) one year after symptom onset | To evaluate of the predictive properties of conventional (DTI) and functional imaging (resting state) one year after symptom onset | one year after symptom onset | 
| Transcriptome analyses | To perform transcriptome analyses to identify new biomarkers which may predict the one year- neurological outcome | one year after symptom onset | 
| Predictive properties of immune parameters in the cerebrovascular fluid for functional outcome one year after symptom onset | To evaluate of the predictive properties of immune parameters in the cerebrovascular fluid for functional outcome one year after symptom onset | one year after symptom onset | 
| Quality of life and occurence of depression in patients one year after symptom onset | To investigate the quality of life and the occurence of depression in patients one year after symptom onset | one year after symptom onset | 
| Quality of life and the occurence of depression and burnout syndrome in relatives | To investigate the quality of life and the occurence of depression and burnout syndrome in relatives of patients treated on the neurological intensive care unit one year after symptom onset | one year after symptom onset | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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severe neurological diseases, neurological intensive care unit, prediction, long-term outcome, biomarkers, prediction of long-term outcome