Study of Motor Representations in Healthy Subjects and Amnestic MCI

Study Overview
=================
Brief Summary
-----------------
Walking, Brain and Functional Magnetic Resonance Imaging Study of motor representations in healthy subjects and amnesic MCI.

Detailed Description
-----------------
Review and compare mapping brain activation in Magnetic Resonance Imaging about healthy subjects according to age (<40 years and> 60 years) and MCI through the combination of two paradigms: on mechanically simulated by Korvit® boots and imagination of the walk.

Official Title
-----------------
Walking, Brain and Functional Magnetic Resonance Imaging Study of Motor Representations in Healthy Subjects and Amnestic MCI

Conditions
-----------------
Mild Cognitive Impairment

Intervention / Treatment
-----------------
* Radiation: Brain MRI


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Obtaining the signature of consent to participation in the study Age above 18 years Lack dementia as NICDS-ADRDA criteria Lack of pre-existing musculoskeletal disorders, regardless of the cause (except MCI). Absence of a history of stroke or other cerebrovascular disease with spinal sensorimotor sequelae. No cons-indication for performing a brain MRI. Witennses, population of young (<40 years) Witnesses ,population of older subjects (> 60 years) Witnesses Lack of MCI MCI patients, criteria MCI criteria according to Dubois Exclusion Criteria : Refusal of MRI. Contraindications to brain MRI.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Control subjects under 40 years<br>Brain MRI Simulated walking with Corvit boots Records gait parameters on Gaitrite carpet | Radiation: Brain MRI<br>* Brain MRI (Magnetic Resonance Imaging) brain is a painless test that allows to visualize the different brain structures. Korvit, device made up of 2 shoes which reproduces the feeling to go. The Korvit® system appears possible to analyze the activated cerebral zones and to thus try to better understand the operation of the brain during walk. The GAITRite is a carpet for recording the walking operating parameters<br>* Other names: GAITRite;|
| Control subjects over 60 years<br>Brain MRI Simulated walking with Corvit boots Records gait parameters on Gaitrite carpet | Radiation: Brain MRI<br>* Brain MRI (Magnetic Resonance Imaging) brain is a painless test that allows to visualize the different brain structures. Korvit, device made up of 2 shoes which reproduces the feeling to go. The Korvit® system appears possible to analyze the activated cerebral zones and to thus try to better understand the operation of the brain during walk. The GAITRite is a carpet for recording the walking operating parameters<br>* Other names: GAITRite;|
| MCI subjects over 60 years<br>Brain MRI Simulated walking with Corvit boots Records gait parameters on Gaitrite carpet | Radiation: Brain MRI<br>* Brain MRI (Magnetic Resonance Imaging) brain is a painless test that allows to visualize the different brain structures. Korvit, device made up of 2 shoes which reproduces the feeling to go. The Korvit® system appears possible to analyze the activated cerebral zones and to thus try to better understand the operation of the brain during walk. The GAITRite is a carpet for recording the walking operating parameters<br>* Other names: GAITRite;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Review and compare mapping cerebral activation in brain MRI | Review and compare mapping brain activation in healthy about MRI according to age (<40 years and> 60 years) and MCI through the combination of two paradigms: on mechanically simulated by Korvit® boots and imagination the walk. The primary endpoint is the analysis of fMRI brain mapping in accordance with the different paradigms of acquisition. The MRI data will be the subject of a specific statistical treatment, via dedicated software, which will be implemented under the control of the investigators who have conducted such an fMRI analysis in previous studies. Various brain mapping can be established from the data collected. It may include statistical comparisons between different preselected regions, and different experimental conditions, or correlation studies between brain activation and clinical parameters. | One day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Review and compare mapping brain activation in healthy subjects and MCI MRI in imagination alone walking. | Review and compare mapping brain activation in healthy subjects and MCI MRI in imagination alone walking. the secondary endpoint will be the analysis of spatiotemporal gait parameters | One day | 
| Study of differences in terms of activation of brain mapping | Study of differences in terms of activation of brain mapping between mechanical stimulation task arch simulating the place of the step (pace to 120 steps per minute) and a random mechanical stimulation (not reproducing the place of the pitch) . the secondary endpoint will be the analysis of spatiotemporal gait parameters | One day | 
| study of functional connectivity of sensorimotor cortex obtained by fMRI resting in the subject MCI. | study of functional connectivity of sensorimotor cortex obtained by fMRI resting in the subject MCI. the secondary endpoint will be the analysis of spatiotemporal gait parameters | One day | 
| study of the potential effects on muscle activation, and autonomic nervous system | study of the potential effects on muscle activation, and autonomic nervous system of plantar mechanical stimulation reproducing walking. the secondary endpoint will be the analysis of spatiotemporal gait parameters | One day | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Mild Cognitive Impairment, Magnetic Resonance Imaging