StO2 Performance Measured on Admission to the Emergency Department in the Assessment of Drug Poisoning

Study Overview
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Brief Summary
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The primary purpose of the protocol is to evaluate the StO2 performance measured at the admission to the emergency department to identify hemodynamic failure at the admission or within the first three hours of monitoring patients with drug poisoning. The study hypotheses are: The early detection of hypoperfusion by StO2, essential to prevent the development of collapse. To limit hemodynamic failure effects, reduce morbidity and mortality of drug poisoning, hospital stay and cost.

Detailed Description
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The procedure is a measurement and non-invasive monitoring system of percentage of oxygen saturation of haemoglobin in tissues using infrared technology. The system used in the study is the tissue oxygenation monitor InSpectraTM StO2 Spot Check, Model 300 consisting of a clamp applied to the base of the thumb of the patient.

Official Title
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Percentage of Oxygen Saturation of Haemoglobin in Tissues (StO2) Performance Measured on Admission to the Emergency Department in the Assessment of Drug Poisoning

Conditions
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Drug Poisoning

Intervention / Treatment
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* Device: Measurement of StO2


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: admitted to the emergency department, whose pattern of hospitalization is drug poisoning, defined on data from the patient's interrogation or his family if the patient is not able to answer, Written informed consent signed by the patient or, if he's unable to sign, by a companion, Affiliated to medical insurance Exclusion Criteria: Patients without thenar eminence or having a disease of the thenar, Refusal to participate in the study, Participation in another biomedical research, Patient under guardianship, trusteeship or judicial protection, Pregnant women or nursing mothers

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Measurement of StO2<br>The procedure is a measurement and non-invasive monitoring system of percentage of oxygen saturation of haemoglobin in tissues using infrared technology. The system used in the study is the tissue oxygenation monitor InSpectraTM StO2 Spot Check, Model 300 consisting of a clamp applied to the base of the thumb of the patient. | Device: Measurement of StO2<br>* The procedure is a measurement and non-invasive monitoring system of percentage of oxygen saturation of haemoglobin in tissues using infrared technology. The system used in the study is the tissue oxygenation monitor InSpectraTM StO2 Spot Check, Model 300 consisting of a clamp applied to the base of the thumb of the patient.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| StO2 performance measured to identify hemodynamic failure. |  | Outcome measure is assessed during three hours after the admission to the emergency department. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| StO2 distribution |  | Outcome measure is assessed during three hours after the admission to the emergency department. | 
| StO2 threshold value to predict the onset of hemodynamic failure |  | Outcome measure is assessed during three hours after the admission to the emergency department. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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emergency, drug poisoning, StO2 measurement, blood pressure, hemodynamic failure