The Effect of Percutaneous Radiofrequency Ablation of Feeding Arterial for Hepatocellular Carcinoma

Study Overview
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Brief Summary
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To evaluate a novel technique-ultrasound guided percutaneous abaltion of tumor feeding artery before RFA for liver malignancy.

Detailed Description
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Hepatocellular carcinoma is one of the most common tumor in clinical practice. In recent years, various local therapies, especially radiofrequency ablation (RFA) has been proved safe and effective.The main limitation of RFA is that its therapeutic impact is significant compromised by blood flow cooling effect, especially in hypervascular HCC. Recent studies showed combined therapy of TACE and RFA can decrease the blood supply of tumor, increase ablated volume and therefore improve the outcome. However, TACE application is limited in patients who cannot tolerate this therapy due to the side effects of repeated TACE, poor liver function or previously legated hepatic artery. The present study is focus on difficult-to-treat HCC patients who are neither surgical candidates, nor TACE candidates. The investigators introduce the novel treatment mode that RFA followed ultrasound guided percutaneous ablation of tumur feeding arterial to treat these difficult cases and evaluate the clinical effect.

Official Title
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The Clinical Value of Percutaneous Radiofrequency Ablation of Feeding Arterial for Hepatocellular Carcinoma

Conditions
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Liver Neoplasms

Intervention / Treatment
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* Other: PAFA
* Other: tumor ablation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: tumor number ≤3， maximum tumor size ≤5cm; accessibility of tumors via a percutaneous approach; tumor feeding artery can be detected by 3D contrast enhance ultrasound; platelet count ≥ 50,000/ml and INR <1.6; life expectancy more than 6 months Child grade A or B Exclusion Criteria: patients who scheduled liver transplantation with extrahepatic metastasis women during menstruation, pregnancy, child birth and baby nursing period patients with severe mental disorder cardiopulmonary failure

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: PAFA and tumor ablation<br>first percutaneous frequency ablation of tumor feeding artery and then ablation of tumor | Other: PAFA<br>* percutaneous ablation of tumor feeding artery<br>* Other names: percutaneous ablation of tumor feeding artery;Other: tumor ablation<br>* ablation of tumor area directly<br>|
| Other: tumor ablation<br>ablation of tumor directly | Other: tumor ablation<br>* ablation of tumor area directly<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| completed tumor necrosis | Contrast enhanced CT or MRI was examed to evaluate tumor necrosis 1 month after ablation. | 1 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| tumor recurrence | tumor recurrence around the ablation zone | up to 36 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Ablation Techniques