Serum Immunologic Markers Levels in During the Delivery

Study Overview
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Brief Summary
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This study aim to describe dynamics of immunologic markers C1 inhibitor, C3, C4 during the delivery in order to improve early diagnostics of obstetric emergencies, especially with immune etiology.

Detailed Description
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Our prospective observational study will explore the differences between dynamics of the complement components C1 inhibitor, C1 inhibitor activity, C3, C4 during the labour in a group of women with physiologic pregnancy and in a group with a risk of complications (pre-eclampsia, HELLP syndrome, placenta praevia, placental abruption, IUGR, previous post partum hypotony). We will focus on women undergoing the Caesarean delivery. We will also measure D vitamin levels and ACE levels and search for some contexts.

Official Title
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Dynamics of Serum Immunologic Markers Levels in During the Delivery and Possible Benefit for Obstetric Emergency Diagnostics

Conditions
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Immunologic Markers

Intervention / Treatment
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* Diagnostic Test: Blood sampling


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Pregnant women undergoing the Caesarean delivery Signed informed consent Exclusion Criteria: Previous hepatitis or other hepatocyte damage

Ages Eligible for Study
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Minimum Age: 15 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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Female

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Parturients physiologic pregnancy<br>Parturients undergoing caesarean delivery with physiologic pregnancy | Diagnostic Test: Blood sampling<br>* differences between dynamics of the complement components C1 inhibitor, C1 inhibitor activity, C3, C4 during the labour in a group of women with physiologic pregnancy and in a group with a risk of complications (pre-eclampsia, HELLP syndrome, placenta praevia, placental abruption, IUGR, previous post partum hypotony).<br>* Other names: Blood sample;|
| Parturients with risk pregnancy<br>Parturients undergoing caesarean with risk of complications (pre-eclampsia, HELLP syndrom, placenta praevia, placental abruption, IUGR, previous post partum hypotony). | Diagnostic Test: Blood sampling<br>* differences between dynamics of the complement components C1 inhibitor, C1 inhibitor activity, C3, C4 during the labour in a group of women with physiologic pregnancy and in a group with a risk of complications (pre-eclampsia, HELLP syndrome, placenta praevia, placental abruption, IUGR, previous post partum hypotony).<br>* Other names: Blood sample;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in levels of total C1 inhibitor | Chenge in levels of total C1 inhibitor | 30 minutes before and 30 minutes after delivery | 
| Change in levels of CRP levels | Change in levels of CRP levels | 30 minutes before and 30 minutes after delivery | 
| Change in levels of D vitamin levels | Change in levels of D vitamin levels and it's relationship to pre-eclampsia | 30 minutes before and 30 minutes after delivery | 
| Change in levels of ACE levels | Change in levels of ACE levels | 30 minutes before and 30 minutes after delivery | 
| Change of C1 inhibitor activity | Change of C1 inhibitor activity | 30 minutes before and 30 minutes after delivery | 
| Change in levels of total C3 | Change in levels of total C3 | 30 minutes before and 30 minutes after delivery | 
| Change in levels of total C4 | Change in levels of total C4 | 30 minutes before and 30 minutes after delivery |