Laser Iridotomy Versus Surgical Iridectomy in Early Angle Closure

Study Overview
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Brief Summary
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This is a randomized controlled clinical trial to compare laser peripheral iridotomy(LPI) and surgical peripheral iridectomy. Subjects of primary angle closure suspect, primary angle closure will be randomized to undergo LPI or SPI. Subjects are proposed to be followed up for 3 years.

Detailed Description
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The following will be studied: To evaluate the safety of these two techniques for the treatment of angle closure. To compare the anterior chamber reaction and IOP changes post surgery. TO establish the UBM/ASOCT chamber angle parameters changes pre and post surgery. To assess the development of PAS.

Official Title
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Laser Peripheral Iridotomy Versus Surgical Peripheral Iridectomy in Early Angle Closure:a Randomized Clinical Trial

Conditions
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Intraocular Pressure Changes, Peripheral Anterior Synechiae Increasing

Intervention / Treatment
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* Procedure: Surgical Iridectomy
* Procedure: Laser Iridotomy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: more than 50 years old Diagnosis of either: Primary angle closure suspects, Primary angle closure in need of laser iridotomy or surgical iridectomy Able to give Informed concent Exclusion Criteria: Ophthalmic diseases other than glaucoma and cataract pseudophakic or aphakic patients inability to attend regular follow-up assessment or to give informed written consent Secondary causes of angle closure e.g. subluxed lens, uveitis, trauma and neovascular glaucoma Participating in another study monocular patients

Ages Eligible for Study
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Minimum Age: 50 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: PACS<br>primary angle closure suspects | Procedure: Surgical Iridectomy<br>* Surgical Iridectomy is now widely used in our clinical.<br>* Other names: Peripheral Surgical Iridectomy;Procedure: Laser Iridotomy<br>* alternative choice to surgical iridectomy<br>* Other names: Peripheral Laser Iridotomy;|
| Experimental: PAC<br>primary angle closure | Procedure: Surgical Iridectomy<br>* Surgical Iridectomy is now widely used in our clinical.<br>* Other names: Peripheral Surgical Iridectomy;Procedure: Laser Iridotomy<br>* alternative choice to surgical iridectomy<br>* Other names: Peripheral Laser Iridotomy;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| intraocular pressure |  | 3 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Angle assessment parameters | Angle assessment parameters,such as anterior chamber openning distance,are acquired by anterior segment optical coherence tomography. | 3 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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intraocular pressure, Peripheral anterior synechiae