Neural Bases of the Check Process

Study Overview
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Brief Summary
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Effective exploration of the environment, check for information to improve one's own performance, are fundamental abilities of human cognition. These abilities are dependent on the process of cognitive control. However, they are clearly impaired and uncontrollable in certain behavioral disorders such as obsessive-compulsive disorder (OCD). Compulsive checks of these patients, spontaneously associated with a feeling of intense uncertainty, suggest disturbances of evaluative and metacognitive functions. However, no biological observations have yet been able to feed these hypotheses. The evaluation of decisions and actions involves the middle cingulate cortex (MCC) (which belongs to a cortico-subcortical network structurally and functionally altered in OCD patients). Cingulotomy has long been used as a therapy in severe OCD, with However, the precise part of the cingulate cortex that contributes to check (and its pathological forms) remains to be discovered. The purpose of this research campaign is to determine, through functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) in healthy human subjects: the location and role of the MCC region involved in normal check decision processes, determine the identity of the entire network involved

Official Title
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Neural Bases of the Check Process

Conditions
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Healthy Volunteers

Intervention / Treatment
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* Other: fMRI and EEG study


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: adults age range 20-45 years being able to provide a written consent form having a social insurance have a normal vision (with or without corrections) Right-handed Exclusion Criteria: Subjects with MRI contraindications (e.g. pacemaker, claustrophobia, metal in the body, etc…). Pregnant subjects Subjects with neurological history Subjects must be willing to be advise in case of discovery of brain abnormality.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: fMRI and EEG study<br> | Other: fMRI and EEG study<br>* fMRI and EEG study<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measuring changes in brain activity in regions of interest when performing cognitive tasks. | Behavior: Measurement of reaction times of correct answer during cognitive task. fMRI and EEG: Brain activity signal, | through study completion, an average of 3 years | 
| Measuring changes in brain activity in regions of interest when performing cognitive tasks. | Behavior: Measurement of % of correct answer during cognitive task. | through study completion, an average of 3 years | 
| Measuring changes in brain activity in regions of interest when performing cognitive tasks. | - Measurement of the amplitude of the BOLD signal change in MRI according to the different cognitive tasks in the different regions of interest. Measurement of resting GABA and Glutamate concentrations in the different regions of interest. Measurement of the amplitude of the change of the electrical signal in EEG according to the different cognitive tasks in the different regions of interest. | through study completion, an average of 3 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Calculation of the correlations in the regions of interest of the individual values of the Blood Oxygen Level Dependent (BOLD) signal with the data of the concentration of Acide γ-aminobutyrique (GABA) | calculate with the bold signal (spectroscopy) | through study completion, an average of 3 years | 
| Calculation of the correlations in the regions of interest of the individual values of the Blood Oxygen Level Dependent (BOLD) signal with the data of the amplitude of the electrical signal (EEG) |  | through study completion, an average of 3 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Gyrus Cinguli, Cognitive Control Process, Check process, Decision Making, fMRI