Effect of Acute Dietary Supplementation With Grape Seed Extract on Aortic Stiffness, Arterial Pressure, and Blood Vessel Dilation in Collegiate Obese Individuals at Rest

Study Overview
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Brief Summary
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This study investigated if elevated BP and aortic stiffness characterized in obese individuals are attenuated following acute grape seed extract supplementation. It is hypothesized that acute dietary supplementation with grape seed extract attenuates aortic stiffness, systolic blood pressure, diastolic blood pressure, mean arterial pressure, and total peripheral resistance and these effects are partially due to reductions in peripheral vasoconstriction

Detailed Description
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Twenty men (obese = 10; normal body weight (NBW) = 10) participated in this study. Effects of placebo (PL: 600 mg) and GSE (600 mg) on systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), stroke volume (SV), cardiac output (Q), total peripheral resistance (TPR), and AoS were compared 2 h after ingestion of GSE or PL on different days, one week apart. Arterial blood pressure was measured using a sphygmomanometer from a brachial artery at the level of the heart on chair. HR and SV were continuously measured using a non-invasive device (Physio Flow). CO was calculated by HR X SV. TPR was calculated by MAP/CO.

Official Title
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Effects of Acute Grape Seed Extract Supplementation on Hemodynamics in Obese Males

Conditions
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Obesity

Intervention / Treatment
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* Dietary Supplement: Grape seed extract


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Obesity: body mass index (>30), Normal body weight: body mass index (25-29) Exclusion Criteria: cardiovascular diseases or consume any antihypertensive medication or supplementation that can affect blood pressure or aortic stiffness

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 29 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: GSE group<br>Subjects took a single dose of 600 mg GSE in capsule form through ingestion 2 hours prior to testing | Dietary Supplement: Grape seed extract<br>* Two capsule grape seed extract (total 600 mg)<br>|
| Placebo Comparator: Placebo group<br>Subjects took a single dose of 600 mg starch in capsule form through ingestion 2 hours prior to testing | Dietary Supplement: Grape seed extract<br>* Two capsule grape seed extract (total 600 mg)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change in heart rate | beats per minute | 2 hours after each supplementation | 
| change in stroke volume | volume per stroke | 2 hours after each supplementation | 
| change in cardiac output | total volume for a minute | 2 hours after each supplementation | 
| change in systolic blood pressure | pressure exerted during contraction | 2 hours after each supplementation | 
| change in diastolic blood pressure | pressure exerted during relaxation | 2 hours after each supplementation | 
| change in mean arterial pressure | One reported pressure (systolic blood pressure-diastolic blood pressure)/3 + diastolic blood pressure | 2 hours after each supplementation | 
| change in total peripheral resistance | One reported value (mean arterial pressure/cardiac output) | 2 hours after each supplementation |