linjc16/ctgov huggingface dataset:
Studies of Neuregulin/ERBB Signaling in Human Heart

Study Overview
=================
Brief Summary
-----------------
This study examines the role of the epidermal growth factor (EGF) receptor family and the EGF family of ligands in the regulation of non-myocytes isolated from the human heart.

Detailed Description
-----------------
The EGF family of receptor tyrosine kinases (a.k.a. ERBB receptors) mediate the effects of the epidermal growth factor (EGF) family including Neuregulin-1β (NRG). NRG and ERBB1-4 are critical for cardiac development and maintenance of the adult heart. Current understanding of the role of EGF/NRG/ERBB signaling in the cardiovascular system is rapidly evolving due to recent findings in non-myocyte cell populations. This study is examining a population of progenitor cells in the adult human heart that responds to EGF and NRG. Subjects are enrolled who are scheduled to undergo heart surgery and are willing to allow for a small biopsy to be taken from their hearts during surgery. Biopsies are taken to the laboratory where cells are separated and analyzed by flow cytometry and grown in cell culture to understand how their biology is regulated by NRG and EGF.

Official Title
-----------------
Isolation and Characterization of ERBB Expressing Human Heart Progenitor Cells

Conditions
-----------------
Heart Disease, Vascular Disease, Heart Failure

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Clinical diagnosis of severe coronary artery disease scheduled to undergo coronary artery bypass surgery. Exclusion Criteria: less than 18 years of age unwilling or unable to provide informed consent known active myocarditis hypertrophic cardiomyopathy constrictive pericarditis or other significant pericardial disease severe pulmonary hypertension significant renal impairment (Cr > 2.5 mg/dL) severe ventricular arrhythmias pregnancy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The number of highly proliferative clones isolated |  | up to 14 days from isolation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Flow cytometric ERBB receptor expression in highly proliferative clones isolated from heart tissue |  | up to 14 days from isolation |
DPBRN Reasons for Replacement or Repair of Dental Restorations

Study Overview
=================
Brief Summary
-----------------
The purpose of this study was to document the reasons for replacement or repair of defective restorations (fillings) and to record the restorative material of the failed restoration and the material used in the replacement restoration on permanent (adult) teeth.

Detailed Description
-----------------
The aims of this study were to (1) quantify the prevalence of reason(s) for replacing existing restorations in DPBRN practices; (2) quantify the percentages and types of restorative materials of failed restorations that are being replaced in DPBRN practices; (3) quantify the percentages and types of restorative materials used to replace or repair failed restorations in DPBRN practices; and (4) test the hypothesis that DPBRN practitioner-investigators who reported in a previous study that they treat enamel lesions operatively are more likely in actual patients as in this study to replace entire restorations rather than do repairs and are more likely to report the clinical diagnosis of secondary caries as a reason for replacement.

Official Title
-----------------
Reasons for Replacement or Repair of Dental Restorations

Conditions
-----------------
Dental Caries

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: participants directly involved in this study were patients who sought dental treatment in the practitioner-investigators practices any tooth surface that was previously restored was eligible for this study, provided that it was on a permanent (adult) tooth. This means that permanent first molars were eligible, which typically erupt at about age 6 years. This means that persons age 6 and older were enrolled in the study and there was no upper age limit.

Ages Eligible for Study
-----------------
Minimum Age: 6 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Dental Caries, Assessments, dental materials
Visual Analogue Scale - a Quality Assurance Study

Study Overview
=================
Brief Summary
-----------------
It has come to our attention that there is not a general consensus of how to apply Visual Analogue Scale (VAS) as a tool in measuring pain amongst postoperative patients in Denmark. The assumption is that patients will grade the level of pain differently dependent on how VAS is presented.

Detailed Description
-----------------
To ensure the data is valid for the study it has been decided to base the research material on four different VAS usage, as it is most often used in clinical practise in Denmark. Which in this case implies VAS horizontal, with and without endpoint, and VAS vertical, with and without endpoint. Every participant will grade their pain on each of the listed VAS representations. Furthermore, as a guideline, the participant will be asked to grade the pain on a Numerical Ranking Scale (NRS). The ordering of VAS lines will be subject to randomization, for each participant

Official Title
-----------------
Visual Analogue Scale (VAS) - a Quality Assurance Research Study to Assess the Quality of the VAS as a Means for Measuring Postoperative Pain.

Conditions
-----------------
Surgery

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patient must have undergone surgery within the last five days The patient must be able and willing to participate in the study Must be at 18 years of age or older A patient can only participate one time. Exclusion Criteria: Previously included patients Medically treated patients Linguistic difficulties Mentally or physically exhausted

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| agreement in VAS values with horizontal vs vertical and with and without stop lines |  | First five days after surgery |
Episodic Memory Before and After Surgery in Drug-resistant Partial Epilepsies

Study Overview
=================
Brief Summary
-----------------
This study has two purposes: firstly, a better understanding of the neurobiological processes underlying episodic memory and, secondly, the development of useful clinical applications for epileptic patients, in particular the prediction of postoperative memory deficits and the development of cognitive remediation therapies. Memory performances during a fMRI experiment will be assessed in controls and epileptic patients before and after the surgery.

Official Title
-----------------
Etude de la mémoire Avant et après Chirurgie d'Une épilepsie Partielle pharmacorésistante : Bases Neurobiologiques, Applications Cliniques

Conditions
-----------------
Epilepsy, Unspecified, Pharmacologically Resistant, Memory Impairment

Intervention / Treatment
-----------------
* Other: No intervention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with drug-resistant epilepsy Age of 18 years or more Follow-up in the epilepsy unit at Pitié-Salpêtrière Hospital Before or after the presurgical evaluation unit including a video-EEG monitoring, a structural brain imaging and a full neuropsychological assessment Covered by a social security system Signing of consent form Exclusion Criteria: Persons under guardianship, curatorship or any other administrative or judicial deprivation of rights and freedom Refusal to consent form Contraindications to MRI Pregnancy Refusal to be informed in the case of detection of an abnormality during the experiment

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: memory outcome<br> | Other: No intervention<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measure of successfull encoding | Our goal is to define correlation between the measure of successfull object encoding trials (especially for binding) and the beta value activation in fMRI | 8 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
epilepsy, surgery, functional MRI, memory outcome
Skin Sterility After Ethyl-Chloride Spray

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to investigate sterility of ethyl-chloride topical anesthetic spray when used prior to an injection. The hypothesis is that the spray does not change the sterility of the injection site after skin is prepped.

Detailed Description
-----------------
This is an IRB-approved, prospective, blinded, controlled study. In the first set of experiments, skin sterility is assessed. Healthy adult subjects are prepared for mock injections of shoulders and knees. No injection is performed. Each site has a set of 3 skin cultures: 1) prior to the alcohol prep (pre-prep), 2) post-alcohol prep (pre-spray), and 3) after ethyl-chloride was sprayed on the site (post-spray). In the second set of experiments, sterility of ethyl chloride is tested directly by culturing the liquid from the spray bottles.

Official Title
-----------------
Skin Sterility After Ethyl-Chloride Spray

Conditions
-----------------
Skin Sterility After Use of Ethyl-chloride Spray.

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age -- 18-85 healthy skin at shoulder and knee area Exclusion Criteria: allergy to ethyl-chloride skin lesions at shoulder or knee

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Healthy Volunteers<br>15 healthy volunteers were recruited | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| culture positivity | Cultures before and after Ethyl-Chloride spray are compared to see if there is any difference. | 5 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Native skin flora | Cultures of skin prior to skin prep are taken to define to native flora at the shoulder and knee area. | 5days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Topical, Skin, sterility, ethylchloride, ethyl, chloride, spray
A Randomized Trial on Platelet Rich Plasma Versus Saline Dressing of Diabetic Foot Ulcers

Study Overview
=================
Brief Summary
-----------------
New treatments for persistent DFU have emerged, among which are the bioengineered skin substitutes, extracellular matrix proteins products, matrix metalloproteinases modulators, and growth factor therapy. Platelet rich plasma (PRP) gel has been used for stimulating wound healing since the last decade of the 20th century. This randomized trial was conducted to assess the role of PRP in gel form as a treatment for clean non-healing diabetic foot ulcer in comparison to regular dressing with saline as a control.

Official Title
-----------------
A Randomized Controlled Trial on Platelet Rich Plasma Gel Compared to Normal Saline Dressing of Diabetic Foot Ulcers

Conditions
-----------------
Diabetic Foot

Intervention / Treatment
-----------------
* Drug: PRP gel
* Drug: Saline dressing


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: adult patients of both sexes aging below 70 years with non-infected chronic foot ulcer confined to one anatomical site. Chronicity was defined as non-healing ulcer for twelve or more weeks Exclusion Criteria: Patients with chronic limb ischemia. Evidence of osteomyelitis in the affected foot Exposed tendons, ligaments or bones at the base of ulcer Patients who received radiotherapy or chemotherapy at time of study or within 3 months of its beginning. Patients having low peripheral platelet count, low serum albumin level or low hemoglobin level

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: PRP gel<br>PRP gel was applied to the ulcer twice per week after preparation and then the ulcer was covered with Vaseline gauze, few layers of sterile gauze and crepe bandage. | Drug: PRP gel<br>* The PRP gel is applied on the ulcer twice per week<br>|
| Active Comparator: Saline dressing<br>daily dressing of the ulcer with normal saline was done | Drug: Saline dressing<br>* Normal saline is used for dressing of the ulcer twice a week<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percent reduction in the ulcer size | the difference between ulcer size before and after treatment subdivided by the ulcer size before treatment | 20 weeks |
Infectious Pseudochromdrosis Caused by Bacillus Cereus

Study Overview
=================
Brief Summary
-----------------
Twelve patients with blue sweat (infectious pseudochromhidrosis) caused by Bacillus cereus.

Detailed Description
-----------------
Case series/observational study. Twelve patients with blue sweat (infectious pseudochromhidrosis) caused by Bacillus cereus. Demography, clinical presentation, diagnosis, treatments, microbiology and causality.

Official Title
-----------------
Blue Sweat - Infectious Pseudochromdrosis Caused by Bacillus Cereus

Conditions
-----------------
Infectious Disease, Bacterial Overgrowth, Pigment Deposition

Intervention / Treatment
-----------------
* Other: Antimicrobial therapy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Infectious pseudochromhidrosis caused by Bacillus cereus Exclusion Criteria: Other types of blue chromhidrosis
Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Antimicrobial therapy|Antimicrobial therapy|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Remission | Descriptive / physical examination | 1 year | 
| Repeated bacteriological swab | Repeated bacteriological swab if uncertainty in terms of complete remission | 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Infectious pseudochromhidrosis, Chromhidrosis, Sweat, Bacillus cereus
Efficacy of Retinal Nerve Fiber Layer (RNFL) / Ganglion Cell Layer Thickness Ratio by RT-View Utilizing Spectral -Domain Technology as a Diagnostic Predictor of Glaucoma.

Study Overview
=================
Brief Summary
-----------------
RT-View utilizes spectral domain technology to assess both RNFL and ganglion cell layer thickness. This study aims to correlate visual field defects in patients with glaucoma to both RNFL and ganglion cell layer thickness.

Conditions
-----------------
Primary Open Angle Glaucoma

Participation Criteria
=================
Eligibility Criteria
-----------------
Exclusion Criteria: Evidence of retinal disease Neovascular glaucoma Secondary glaucoma due to intraocular inflammation Lens induced glaucoma Tumor induced glaucoma

Ages Eligible for Study
-----------------
Minimum Age: 10 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>Primary open angle glaucoma | |
| 2<br>Normal controls | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ganglion cell layer thickness |  | 1 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Visual field defect |  | 1 month | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
RT-View, Spectral domain OCT, Ganglion cell layer, RNFL, Visual field defect
Performance of Scoring Systems in Chinese Patients With Primary Biliary Cholangitis (PBC) on Ursodeoxycholic Acid

Study Overview
=================
Brief Summary
-----------------
Several risk assessment scoring systems have been proposed to assess the therapeutic response and predict long term prognosis in ursodeoxycholic acid (UDCA)-treated primary biliary cholangitis (PBC) patients, in order to risk stratify PBC patients and guide their management. However there scoring systems have not been fully validated in Chinese population. This study is going to compare the prognostic ability of these criteria, validate the overseas scoring systems, develop and validate a new scoring system in a cohort of Chinese PBC patients.

Official Title
-----------------
Performance of Biochemical Response Criteria and Risk Scoring Systems in Chinese Patients With Primary Biliary Cholangitis (PBC) on Ursodeoxycholic Acid

Conditions
-----------------
Primary Biliary Cholangitis (PBC)

Intervention / Treatment
-----------------
* Drug: Ursodeoxycholic Acid


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: With liver biopsy proved PBC Exclusion Criteria: A positive serological test for hepatitis B or C virus, Comorbidity of primary sclerosing cholangitis, Alcoholic liver disease, Hemochromatosis, Wilson's disease, a1-antitrypsin deficiency Presence of complications of cirrhosis (Total bilirubin >100 lmol/L, ascites, variceal haemorrhage and hepatic encephalopathy) on admission.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| PBC patients with liver biopsy<br>Ursodeoxycholic acid will be given compliance to the treatment guideline. | Drug: Ursodeoxycholic Acid<br>* Standard care of PBC patients<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Liver related Death | Whether the patients die from liver-related causes during the follow-up | During follow-up after a year of starting UDCA, an average of 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Complications of cirrhosis | Whether the complication of cirrhosis i.e. ascites, hepatic encephalopathy, variceal bleeding occur during the follow-up | During follow-up after a year of starting UDCA, an average of 1 year | 
| Liver transplant | Whether the patients have liver transplant during the follow-up | During follow-up after a year of starting UDCA, an average of 1 year |
A Qualitative and Quantitative Analysis on the Living History of Survivors From Charcoal-burning Suicide

Study Overview
=================
Brief Summary
-----------------
The current study aims to explore the risk factors, protective factors, resilient factors, and factors jeopardizing the recovery progress on survivors from charcoal-burning suicide. To this end, an in-depth individual interview and Mini-Mental State Examination(MMSE) will be used to acquire the first-hand information on the attempters. As well, a more comprehensive neuropsychological test, WAIS III, will be administered at 3-month, 6-month, and 12-month after the index suicide attempt.

Official Title
-----------------
A Qualitative and Quantitative Analysis on the Living History of Survivors From Charcoal-burning Suicide

Conditions
-----------------
Suicide

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: above 20 years old, survivors from charcoal-burning suicide. Exclusion Criteria: under 20 years old survivors from other kind of suicide prisoner suffer from a serious illness foreigner/ can't speak Chinese the people who can't express themselves can not be interviewed in FEMH people with severe physical or psychological symptoms

Ages Eligible for Study
-----------------
Minimum Age: 20 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| survivors from charcoal-burning suicide<br>survivors from charcoal-burning suicide and at least above 20 years old. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| MMSE score |  | once | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
in-depth individual interview, charcoal-burning suicide