Correlation of Clinical and Laboratory Findings and Diuretic Efficacy in Patients With Edematous States in the Emergency Department

Study Overview
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Brief Summary
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The aim of the study is the characterization of parameters from medical history, physical examination and diagnostics, which correlate with and could be used to predict diuretic efficacy.

Detailed Description
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This prospective observational study is conducted to identify and further isolate possible predictors for the efficacy of diuretics and to identify potential new predictors. The study also observes if specific diuretic regimes (e.g. combination of loop diuretics and distal effective diuretics for sequential nephron blockade) have a greater diuretic effect. This is not yet proved. The data of the study shall to help to determine criteria, allowing to choose an effective diuretic regime in different patient cohorts already at the beginning of therapy and to identify patients at high risk.

Official Title
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Correlation of Clinical and Laboratory Findings and Diuretic Efficacy in Patients With Edematous States in the Emergency Department

Conditions
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Edema

Intervention / Treatment
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* Other: Characterization of parameters of medical history, examination and diagnostics.


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age over 18 years. Edema (peripheral and/or pulmonal) of cardiac or renal genesis. Exclusion Criteria: Persons who are in a dependency/employment relationship with the investigators. Accommodation in an institution by judicial or administrative order. Patients in need of ascites puncture and/or thoracentesis on admission day.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with edematous states<br>Patients with edematous states receive standard of care diuretic. | Other: Characterization of parameters of medical history, examination and diagnostics.<br>* Patients receive standard of care diuretics. The study only collects data to characterize parameters of medical history, examination and diagnostics.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Multivariable regression analysis at 6±1 hours | Multivariable regression analysis at 6±1 hours from timepoint of first diuretic administration in the emergency department. Independent variables: diuretic dose, clinical characteristics, serum creatinine, serum urea, urine sodium, urine conductivity and others. The dependent variable will be urine volume 6±1h after diuretic therapy or the difference in weight before diuretic administration and 6±1 hours afterwards. | 6±1 hours from timepoint of first diuretic administration in the emergency department | 
| Multivariable regression analysis 24 hours time course | Multivariable regression analysis over 24 hours time course from timepoint of first diuretic administration in the emergency department. Independent variables: diuretic dose, clinical characteristics, serum creatinine, serum urea, urine sodium, urine conductivity and others. The dependent variable will be urine volume at different timepoints (e.g. 6h, 18h, 24h) within a maximum of 24 hours after first diuretic administration | 24 hours time course from timepoint of first diuretic administration in the emergency departmentnistration | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Edema