Physical Activity, Insulin Resistance and Function of Fat Tissue in the Offspring of Patients With Type 2 Diabetes

Study Overview
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Brief Summary
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Offspring of patients with type 2 diabetes have increased risk of developing diabetes and are typically more insulin resistant than their peers with no diabetes family history. We have recently demonstrated that, in contrast to their sedentary counterparts, physically active offspring are not insulin resistant. In the proposed controlled clinical study, we will examine the effects of a moderate exercise programme on insulin resistance, and other metabolic risk factors, in sedentary offspring and matched control subjects. We hypothesise that offspring will exhibit an augmented response to exercise, thereby normalising their predisposition to an adverse metabolic profile. We will also investigate expression of adipokines and other genes in adipose tissue to determine whether these contribute to the increased insulin resistance observed in offspring and whether they are influenced by exercise. The results will help to determine the efficacy of exercise in normalising metabolism in offspring and will help elucidate the mechanisms involved.

Official Title
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Physical Activity, Insulin Resistance and Adipose Tissue Gene Expression in the Offspring of Patients With Type 2 Diabetes

Conditions
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Type 2 Diabetes Mellitus, Cardiovascular Diseases

Intervention / Treatment
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* Behavioral: Physical activity


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 2 subject groups - 'control' and 'offspring' Offspring - at least 1 parent diagnosed with type 2 diabetes before age 65 Controls - no history of type 2 diabetes in 1st or 2nd degree relatives In generally good health Non-smoker Fasting glucose < 7 mmol/l Blood pressure <160/90 mm Hg No established CHD (e.g. MI, stroke, CABG, PCTA) Exclusion Criteria: Established CHD (e.g. MI, stroke, CABG, PCTA) diabetes smoking hypertension (BP > 160/90 mmHg) pregnancy

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: Physical activity|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Insulin resistance at 8 weeks |  |  | 
| Risk markers for cardiovascular disease/diabetes at 8 weeks |  |  | 
| Adipose tissue gene expression at 8 weeks |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fitness at 8 weeks |  |  | 
| Body composition/adiposity at 8 weeks |  |  | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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exercise, physical activity, insulin resistance, adipose tissue, gene expression