The Efficacy of Nitric Oxide in Stroke (ENOS) Trial

Study Overview
=================
Brief Summary
-----------------
Nitric oxide is a multimodal candidate treatment for acute stroke having a number of properties which may be beneficial in acute stroke, including lowering blood pressure, causing cerebral vasodilation, and improving central and systemic haemodynamics. Nitric oxide donors are effective in experimental stroke and pilot studies in patients suggest that one, glyceryl trinitrate, can be delivered easily in a transdermal preparation. Around half of all patients admitted with acute stroke are taking antihypertensive therapy immediately prior to their stroke. No data exist as to whether it is beneficial or safe to stop or continue this treatment during the acute phase. ENOS is a prospective, international, multicentre, randomised, parallel-group, blinded, controlled, collaborative, factorial trial designed to test two questions related to the management of blood pressure immediately post-stroke: The safety and efficacy of nitric oxide, given as transdermal glyceryl trinitrate. The safety and efficacy of stopping or continuing prior antihypertensive medication. Previously independent adult patients who are conscious and have residual limb weakness are eligible for enrollment. Central randomisation will be performed via the internet. Treatment is initiated within 48 hours of stroke onset and is given as daily glyceryl trinitrate patches for 7 days. A computed tomography (CT) scan is required within 7 days of randomisation. Early follow-up is performed locally over the 7 days of treatment, including blood pressure, early stroke events, and adverse events. Telephone central follow-up by the trial co-ordinating centre will be performed at 3 months. The primary outcome is combined death or dependency (modified Rankin Score >2).

Official Title
-----------------
A Prospective, Collaborative, International, Multicentre, Randomised, Parallel-group, Single and Outcome Blinded, Controlled, Factorial Trial to Investigate the Safety and Efficacy of Treatment With Transdermal Glyceryl Trinitrate, a Nitric Oxide Donor, and of Continuing or Stopping Temporarily Pre-stroke Antihypertensive Therapy, in Patients With Acute Stroke

Conditions
-----------------
Stroke

Intervention / Treatment
-----------------
* Drug: Transdermal glyceryl trinitrate patch
* Drug: Pre-stroke antihypertensives


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adult(> 18 yrs). Clinical stroke syndrome with limb weakness lasting at least 1 hour i.e. not likely to be a transient ischaemic attack). Limb weakness (SNSS Arm <6 and/or Leg <6). Onset < 48 hours. Conscious (Glasgow Coma Scale > 8). Independent prior to stroke (pre-morbid Rankin scale < 2). Meaningful consent, or assent from a relative or carer Exclusion Criteria: Definite need for nitrate therapy Contraindication to nitrate therapy Definite need for prior antihypertensive or anti-anginal medication Definite need for antihypertensive therapy during acute stroke Systolic blood pressure <140 mmHg or >220 mmHg. Patients expected to require surgical intervention Known intracerebral pathology other than stroke Other serious condition which is likely to prevent outcome assessment at 3 months Previous enrollment in ENOS or current involvement in another trial of an experimental drug intervention. Not available for follow-up -Females of childbearing potential, pregnancy or breastfeeding. -

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Glyceryl trinitrate transdermal patch<br> | Drug: Transdermal glyceryl trinitrate patch<br>* 5mg per day<br>* Other names: Local ward stock to be used.;|
| Experimental: Continue or stop pre-stroke antihypertensives<br> | Drug: Pre-stroke antihypertensives<br>* Continue or stop pre-stroke anti-hypertensives<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Reduced death or dependency (modified Rankin score) |  | 90 days |