Thumb Osteoarthritis Mechanisms

Study Overview
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Brief Summary
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This study examines carpometacarpal osteoarthritis (CMC OA) and aims to elucidate the biomechanical, neuromuscular, and somatosensory mechanisms that contribute to CMC OA symptoms by using orthopaedic biomechanics and quantitative pain testing. Completion of this study will provide a comprehensive dataset describing how movement strategies (muscle activity and joint posture) as well as experimental and clinical pain differ between individuals with CMC OA and age-matched controls.

Official Title
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Carpometacarpal Osteoarthritis: Towards Identification of Biomechanical, Neuromuscular, and Somatosensory Mechanisms

Conditions
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Carpometacarpal Osteoarthritis

Intervention / Treatment
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* Other: Range of Motion Tasks
* Other: Strength Tasks


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: CMC OA Subjects: female between the age of 40 to 90 years end-stage CMC OA diagnosed by a board-certified clinician Age-Matched Control: female between the age of 40 to 90 years no joint or muscle pain in the hand or wrist Exclusion Criteria: All Groups: pregnant women; minors (under age 18); mentally disabled; any persons incarcerated, on parole, on probation, or awaiting trial individuals with concomitant musculoskeletal pathologies (other than osteoarthritis) in the hand or wrist, including distal radius fracture, contracture, trigger finger, and carpal tunnel individuals with history of uncontrolled diabetes, rheumatoid arthritis, muscular dysfunction, or neurological disease

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: CMC OA Group<br>During testing, participants will be asked to perform range of motion tasks, as well as strength tasks at varying effort levels (maximal and sub-maximal). Through a combination of quantitative testing and self-reported assessments, data on experimental pain, clinical pain, hand function, and disease severity will be reported. | Other: Range of Motion Tasks<br>* Participants will perform range of motion (thumb only) to evaluate fine and gross motor function.<br>Other: Strength Tasks<br>* Participants will perform strength (pinch and grip) tests to evaluate fine and gross motor function.<br>|
| Active Comparator: Age-Matched Control Group<br>During testing, participants will be asked to perform range of motion tasks, as well as strength tasks at varying effort levels (maximal and sub-maximal). Through a combination of quantitative testing and self-reported assessments, data on experimental pain, clinical pain, hand function, and disease severity will be reported. | Other: Range of Motion Tasks<br>* Participants will perform range of motion (thumb only) to evaluate fine and gross motor function.<br>Other: Strength Tasks<br>* Participants will perform strength (pinch and grip) tests to evaluate fine and gross motor function.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Graded Chronic Pain Scale (GCPS) | GCPS grades the severity of chronic pain in the general population. GCPS is a seven question survey which yields a Characteristic Pain Intensity score and an overall Disability score providing insight into global pain severity. Answers are plotted on a scale from 0-10; with 0 being 'no pain' and 10 being 'pain as bad as could be' or 'extreme.' | Baseline |