Intravenous Magnesium Sulfate Vs Placebo to Treat Non -Traumatic Acute Headaches in the Emergency Department

Study Overview
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Brief Summary
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Intravenous Magnesium Sulfate Vs Placebo to Treat Non -Traumatic Acute Headaches in the Emergency Department

Detailed Description
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Rate of Intravenous Magnesium Sulfate Vs Placebo to Treat Non -Traumatic Acute Headaches in the Emergency Department

Official Title
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Intravenous Magnesium Sulfate Vs Placebo to Treat Non-traumatic Acute Headaches in the Emergency Department

Conditions
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Head Pain

Intervention / Treatment
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* Drug: Magnesium sulfate


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: informed consent age >18 years Acute non-traumatic acute headaches patients treated in ED Magnesium sulfate and aspirin administered intravenously (IV) Exclusion Criteria: Current regular use of analgesics, anticonvulsants or antidepressants Renal disorder with a low glomerular filtration rate (<60 ml/min) Neuromuscular disorder Pregnant woman Contrindication Allergy to NSAID Traumatic Headache Chronic headache ( headache occurring at least 15 days per month for at least 3 months) Hemodynamic instability

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Placebo Group<br>1g paracetamol + 20 min infusion of 150ml of saline serum | Drug: Magnesium sulfate<br>* magnesium group 1g paracetamol + 20 min infusion of 2 g magnesium in 150 ml of saline serum and Placebo Group 1g paracetamol + 20 min infusion of 150 ml of saline serum<br>* Other names: placebo;|
| Experimental: magnesium group<br>1g paracetamol + 20 min infusion of 2g magnesium in 150 ml of serum saline | Drug: Magnesium sulfate<br>* magnesium group 1g paracetamol + 20 min infusion of 2 g magnesium in 150 ml of saline serum and Placebo Group 1g paracetamol + 20 min infusion of 150 ml of saline serum<br>* Other names: placebo;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Intravenous Magnesium Sulfate to Treat Non -Traumatic Acute Headaches in the Emergency Department | Patients with Non -Traumatic Acute Headaches in the Emergency Department recived 1g paracetamol + 20 min infusion of 2g magnesium | 1day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Placebo to Treat Non -Traumatic Acute Headaches in the Emergency Department | Patients with Non -Traumatic Acute Headaches in the Emergency Department received 1g paracetamol + 20 min infusion of saline serum | 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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intavenous, magnesium sulfate, nontraumatic, acute headaches, placebo