Evaluation of Cerebral Small Vessel Disease in Patient With Primary Aldosteronism

Study Overview
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Brief Summary
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Hypertension is known to be the major risk factor for stroke. The most common cause of secondary hypertension, primary aldosteronism (PA), is characterized by the excessive secretion of aldosterone and is related to hypertension and hypokalemia. PA accounts for 3-10 % of hypertensive patients, and a higher incidence of vascular complications compared to patients with essential hypertension was observed in several studies. The vascular injury from excessive aldosterone can occur via oxidative stress and collagen remodeling, causing endothelial dysfunction and fibrosis in the vasculature. The association between cerebral small vessel disease (cSVD) and hypertension has been well studies in the past decades. However, not much study has focused on the cSVD burden in patient with PA. The goal of this study is to understand the features of cSVD in patients with PA and for the purpose of understanding the underlying pathophysiology of cerebrovascular injury in this particular patient group.

Official Title
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Evaluation of Cerebral Small Vessel Disease in Patient With Primary Aldosteronism

Conditions
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Evaluation of Cerebral Small Vessel Disease in Patient With Primary Aldosteronism

Intervention / Treatment
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* Diagnostic Test: Brain MRI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age between 20-90 years-old patient with primary aldosteronism or healthy control consciousness clear willing to receive brain MRI Exclusion Criteria: renal failure or Creatinine > 2mg/dl coagulopathy or hepatic insufficiency unstable vital sign under inotropic agents pregnancy metal implant or cardiac pacemaker major brain surgery

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Patient with primary aldosteronism<br>Brain MRI with T1WI, T2WI, FLAIR, thin-sliced T1WI, DWI, TOF, and blood sensitive sequence (SWI) will be performed. | Diagnostic Test: Brain MRI<br>* Brain MRI with blood sensitive sequence (SWI) will be performed to all enrolled patients.<br>|
| Active Comparator: Patient with essential hypertension<br>Brain MRI with T1WI, T2WI, FLAIR, thin-sliced T1WI, DWI, TOF, and blood sensitive sequence (SWI) will be performed. | Diagnostic Test: Brain MRI<br>* Brain MRI with blood sensitive sequence (SWI) will be performed to all enrolled patients.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cerebrovascular reactivity | Cerebrovascular reactivity measured by MRI under primary aldosteronism | During the brain MRI | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Hypertension,primary aldosteronism