linjc16/ctgov huggingface dataset:
Evaluation of the Neoadjuvant Treatment With Oxaliplatin -UFT- Radiotherapy in Rectal Cancer

Study Overview
=================
Brief Summary
-----------------
Primary objective: - To evaluate the rate of responses to neoadjuvant therapy + radiotherapy Secondary objective: - tolerability (toxicity) and time to progression

Official Title
-----------------
Clinical Study to Evaluate a Protocol of Oxaliplatin -UFT- Radiotherapy for the Neoadjuvant Treatment Rectal Cancer

Conditions
-----------------
Rectal Neoplasms

Intervention / Treatment
-----------------
* Drug: OXALIPLATIN


Participation Criteria
=================
Eligibility Criteria
-----------------
The following information on clinical trials is provided for information purposes only to allow patients and physicians to have an initial discussion about the trial. This information is not intended to be complete information about the trial, to contain all considerations that may be relevant to potential participation in the trial, or to replace the advice of a personal physician or health professional. Main criteria are listed hereafter: Inclusion Criteria: Patients with measurable, histologically proven rectal cancer. No history of previous malignancy but adequately treated skin / cervical cancer. Adequate haematological, renal and liver function. Exclusion Criteria: No cardiopulmonary insufficiency or coronary disease. No sensory neuropathy prior to study.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: OXALIPLATIN|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Tumour response |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Disease free and Overall survival ; Adverse events |  |  |
Abdominal Ultrasonography in Urinary Tract Infection - When and Why?

Study Overview
=================
Brief Summary
-----------------
Urinary tract infection (UTI) in a child may be the first symptom of congenital anomaly of the kidneys and the urinary tract (CAKUT). Thus, imaging diagnostics are warranted in children with first episode of UTI. Abdominal ultrasonography (USG) is the first line imaging modality in evaluating children with UTI. Abnormalities suggesting CAKUT found on USG are an indication for further, more invasive tests. The timing of USG in UTI depends on the clinical situation. It always should be performed urgently when serious acute complications of UTI are suspected. However, appropriate timing of USG in children responding well to therapy, is a matter of debate. According to animal studies, E. coli produces toxin which dilates the urinary tract. This may result in misleading picture on USG in acute phase of infection. Guidelines on UTI management in children differ in respect to recommended USG timing. The purpose of the study is to investigate how UTI does affect USG results in children and when its effect subsides. Methods 150 children up to 3 years of age, with the first episode of UTI, will be included in our study. Three USG examinations will be performed by single radiologist in every child: in the first day of treatment, two weeks after treatment initiation, four weeks after treatment initiation. Age, gender, etiologic factor, C-reactive protein concentration and white blood cells count will be included in statistical analysis. The study is aimed to help clinicians interpret USG findings during UTI and make reasonable plans for further imaging diagnostics in children with UTI.

Official Title
-----------------
Abdominal Ultrasonography in Urinary Tract Infection - When and Why?

Conditions
-----------------
Urinary Tract Infections, UTI

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: - laboratory diagnosis of UTI in a child (positive leucocyturia and significant bacteriuria) Exclusion Criteria: known previous UTIs known congenital abnormality of the kidney and the urinary tract (CAKUT)

Ages Eligible for Study
-----------------
Maximum Age: 3 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| USG abnormality persistence | significant abnormalities within kidney size or calices/pelvis/ureter dimensions, reproducible in subsequent USG examinations | 4 weeks |
Multimodal Retinal Imaging of Cerebrovascular Stroke

Study Overview
=================
Brief Summary
-----------------
The hypothesis is that in patients with stroke, abnormalities of retinal microvascularization shown on color fundus photography and the depletion of retinal capillary density evaluated by OCT-A are markers of acute impairment of microcirculation of the central nervous system and are correlated with lesions on brain imaging. Patients hospitalized for stroke MRI-confirmed, will be included. An ophthalmologic assessment including color fundus photography (CFP) and OCT-A will be carried out after stabilization and at 3 months follow-up. Outcomes assessor will be blinded.

Official Title
-----------------
Multimodal Retinal Imaging of Cerebrovascular Stroke

Conditions
-----------------
Stroke, Cerebrovascular Accidents

Intervention / Treatment
-----------------
* Diagnostic Test: color fundus photography (CFP) and OCT-A


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: Acute ischemic stroke With cerebral microangiopathy (defined by a SVD score > 1) Exclusion criteria: Acute hemorrhagic stroke Anophthalmia

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: color fundus photography (CFP) and OCT-A|Included patients will have an ophthalmologic assessment (OCT-A and CPF) after stabilization and at 3 months follow-up.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Presence of an anomaly in color fundus photography or an anomaly of retinal capillary density to OCT-A |  | 3 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
optical coherence tomography (OCT-A), color fundus photography (CFP), Retinal microvascularization, Cerebral microangiopathy
Infertile Polycystic Ovary Syndrome (PCOS) Women With Obesity and Lifestyle Changes

Study Overview
=================
Brief Summary
-----------------
Infertile PCOS women with obesity were included into lifestyle change weight loss program prior to inclusion to IVF procedures. They attended group as well as individual workouts and they were advised on healthy eating.

Detailed Description
-----------------
The weight loss program will consist of dietary change and exercise program which will be performed 3 times weekly.

Official Title
-----------------
Weight Loss Program in Infertile PCOS Women With Obesity

Conditions
-----------------
Weight Loss

Intervention / Treatment
-----------------
* Behavioral: Weight loss program


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: BMI over 30 kg/m2 PCOS Primary or secondary infertility normal partner's semen Exclusion Criteria: Other identifiable causes of infertility

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 38 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: Weight loss program|Women with obesity were included to the weight loss program which included physical exercise and dietary guidelines|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Body weight (kg) | Body weight before and after the weight loss program will be measured. | 8 weeks | 
| BMI (kg/m2) | BMI before and after the weight loss program will be calculated). | 8 weeks | 
| Waist circumference (cm) | Waist circumference before and after the weight loss program will be measured. | 8 weeks | 
| Abdominal circumference (cm) | Abdominal circumference | 8 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Spontaneous conception rate | Spontaneous pregnancy rate after weight loss program will be calculated. | 3 months |
Endoscopic Tympanoplasty: Single Versus Double Flap Technique

Study Overview
=================
Brief Summary
-----------------
Aim of this study is to compare results of double and single flap techniques for tympanoplasty in chronic suppurative otitis media patients. Inclusion criteria include total or subtotal tympanic membrane perforations with limited anterior remnant and should be dry for at least 3 months. Patients with persistent discharge, cholesteatoma, ossicular affection or those with recurrent perforations after previous myringoplasty were excluded. Also, patients with uncontrolled diabetes, chronic liver and kidney diseases and immuno-compromised patients are not included in this study. Patients are divided into two groups, endoscopic double flap group and endoscopic single flap group. Healing and hearing outcomes were evaluated 3 months postoperative. Also, post-operative pain scores and complications were assessed.

Official Title
-----------------
Endoscopic Tympanoplasty: Single Versus Double Flap Technique

Conditions
-----------------
Tympanic Membrane Perforation

Intervention / Treatment
-----------------
* Procedure: Endoscopic tympanoplasty


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with chronic suppurative otitis media with total or subtotal tympanic membrane perforation with limited anterior remnant. dry perforation for at least 3 months. Exclusion Criteria: Recurrent perforation after previous myringoplasty. Ossicular disruption or fixation. immune-compromised patients including uncontrolled diabetics, chronic liver and kidney diseases.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: endoscopic double flap group<br> | Procedure: Endoscopic tympanoplasty<br>* In the double flap group, graft is placed via elevation of both posterior and anterior flaps. In the single flap group, graft is placed via elevation of posterior flap only<br>|
| Active Comparator: endoscopic single flap group<br> | Procedure: Endoscopic tympanoplasty<br>* In the double flap group, graft is placed via elevation of both posterior and anterior flaps. In the single flap group, graft is placed via elevation of posterior flap only<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Healing or graft take rate | closure of tympanic membrane perforation | 3 months after surgery |
Work of Breathing in Term Infants

Study Overview
=================
Brief Summary
-----------------
This is a prospective observational cohort study conducted in the mother-baby unit at ChristianaCare. The study is designed to assess work of breathing indices and oxygen saturation stability at discharge in full-term infants. Data obtained will be used to perform a comparative analysis on work of breathing data for premature infants obtained from our previous study. We hypothesize full term (≥37 weeks gestation) infants have decreased work of breathing indices (i.e., phase angle) compared to premature infants (born 26-37 weeks gestation) at discharge.

Official Title
-----------------
Comparing Oxygen Saturation Stability and Work of Breathing Between Normal Term Infants and Premature Infants Prior to Discharge

Conditions
-----------------
Work of Breathing, Term Infant

Intervention / Treatment
-----------------
* Other: Work of breathing observation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Infants born ≥37 weeks gestation Admitted to the Mother-Baby Unit Within 24 hours of expected discharge Exclusion Criteria: Infants born between < 37week gestation admitted to the Mother-Baby Unit at CCHS Infants with skeletal, neuromuscular, or abdominal surgical disorders that affect the accuracy of work of breathing measurements will also be excluded.

Ages Eligible for Study
-----------------
Minimum Age: 1 Day
Maximum Age: 1 Week

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Work of breathing observation|We will place soft elastic bands around the infant's chest and abdomen to assess their work of breathing.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Work of breathing indices | A phase angel of 0 represents perfect synchrony between the chest and abdominal compartments. Higher phase angles represent greater degrees of asynchronous breathing. A phase angle of ≥ 40 represents asynchrony and increased work of breathing. A phase angle of 180 represents complete asynchrony. | 25 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Oxygen saturations | Oxygen saturations will be measured by the high-resolution pulse oximeter. | 25 minutes |
Exploratory Study on the Timing of Multiple Sclerosis (MS) Symptoms

Study Overview
=================
Brief Summary
-----------------
The investigators' overall hypothesis is that appearance or worsening of relapsing-remitting multiple sclerosis (RR-MS) symptoms are affected by various factors including stress, hormonal cycles, illness and missed medications.

Detailed Description
-----------------
Fluctuations in MS symptoms in women with RR-MS might be affected by a variety of factors. To determine which factors are important, we are asking subjects to fill out a diary and calendar on a daily basis for 90 days. After an initial instructional meeting over the phone, the materials are filled out at home and returned monthly via postage-paid envelopes provided by the study. Compensation ($10 gift card) is sent after each monthly diary is received. The diary includes a list of symptoms and a rank scale for the women to show subtle changes in MS symptoms. The calendar allows the subject to denote additional factors such as stress, hormonal cycles, illnesses or immunizations and changed or missed medications. We anticipate that statistical analysis will reveal which of these factors affect women with relapsing-remitting multiple sclerosis.

Official Title
-----------------
Exploratory Study on the Timing of MS Symptoms

Conditions
-----------------
Relapsing Remitting Multiple Sclerosis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: females diagnosed with relapsing-remitting multiple sclerosis Exclusion Criteria: male no diagnosis of relapsing-remitting MS diagnosis of any other autoimmune disease or fibromyalgia peri-, post-, or surgically menopausal pregnant within past year or nursing history of chemotherapy on experimental medications treatment with steroids in the last 30 days

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Relapsing-remitting multiple sclerosis<br>Females with relapsing-remitting multiple sclerosis | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| number of days with appearance or worsening of symptoms |  | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| timing of appearance or worsening of symptoms |  | 3 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Multiple Sclerosis, MS, Relapsing-remitting multiple sclerosis, RR-MS, Women
Early Response Assessment in Diffuse Large B-Cell Lymphoma (DLCL) Patients by 18-fluoro-2-deoxyglycose Positron Emission Tomography (FDG-PET)

Study Overview
=================
Brief Summary
-----------------
Newly diagnosed DLCL patients will have baselne FDG-PET as part of initial staging (PET-1). Patients will then undergo 2 cycles of chemotherapy with R/CHOP. 14 to 21 days following cycle 2 of R/CHOP, patients will undergo repeat FDG-PET scan (PET-2). They will then complete therapy as planned. Following completion of therapy, standard response assessment will be performed, including CT scans of the chest, abdomen and pelvis and FDG-PET scan (PET-3).

Official Title
-----------------
Early Response Assessment in Patients With Diffuse Large B-cell Lymphoma Using 18-fluoro-2-deoxyglycose Positron Emission Tomography (FDG-PET)

Conditions
-----------------
Diffuse Large B-cell Lymphoma

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients must have histologically or cytologically confirmed diagnosis of CD20+ diffuse large B cell lymphoma (LBCL) of any stage, including subtypes mediastinal large B cell, centroblastic, immunoblastic, T cell rich B cell and anaplastic B cell lymphoma Patients must have received no prior anti-lymphoma therapy. Age >18 years. Patients must have a treatment plan to include R/CHOP or R/CHOP followed by radiotherapy. Ability to understand and the willingness to sign a written informed consent document. Exclusion Criteria: Patients who have known HIV infection. Patients who are, in the opinion of their treating oncologist, unable to undergo R/CHOP chemotherapy.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| All patients<br>All patients | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| evaluating the predictive value of a positive PET scan early in the course of standard chemotherapy |  | after 2 cycles of chemotherapy | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
diffuse large b cell lymphoma, newly diagnosed
The Analysis of Correlation About the Spot Urine Sodium and the Blood Pressure in General Population According to the Income Level

Study Overview
=================
Brief Summary
-----------------
Increasing sodium intake raises blood pressure. And high salt intake could hinder the management of chronic disease. Much previous research has confirmed that dietary habits are affected by economic status. So we compared sodium intake with economic status. We investigated the prevalence, extent and management, and the relevance of sodium intake with income level.

Conditions
-----------------
Chronic Kidney Disease

Intervention / Treatment
-----------------
* Other: 24_hours_urine_sodium


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: all the patient who participated in the national survey Exclusion Criteria: no pregnancy malignancy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| low sodium group<br>24_hours_urine_sodium < 100 mEq/L | Other: 24_hours_urine_sodium<br> <br> |
| mid sodium group<br>24_hours_urine_sodium >= 100 mEq/L and < 200 mEq/L | Other: 24_hours_urine_sodium<br> <br> |
| high sodium group<br>24_hours_urine_sodium >= 200 mEq/L | Other: 24_hours_urine_sodium<br> <br> |
| low income group<br>the income 25% below the quartile | |
| low mid income group<br>the income 25% - 50% below the quartile | |
| mid income group<br>the income 50% - 75% below the quartile | |
| high income group<br>the income 75% over the quartile | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| sodium intake and the degree of control of blood pressure in general population according to the income level |  | 1 year |