Cerebellar Alterations in Individuals With a Cannabis Use Disorder

Study Overview
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Brief Summary
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The purpose of this study is to investigate if individuals with a cannabis use disorder have an impaired cerebellar function by assessing possible alterations to their implicit adaptation during a visuomotor rotation task.

Official Title
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Alterations in Cerebellar-dependent Adaptation Due to Cannabis Use Measured With an Explicit-implicit Visuo-motor Learning Paradigm

Conditions
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Cannabis

Intervention / Treatment
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* Behavioral: Visuo-motor rotation
* Behavioral: Explicit strategy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients diagnosed with a Cannabis use disorder following Diagnostic and Statistical Manual (DSM-V) criteria. Patients screen positive to cannabis in the urine analysis performed a week prior to assessment. Right-handed patients. Patients provide a signed consent. Exclusion Criteria: Patients with another current substance use disorder (with the exception of tobacco). Patients with a visual impairment that has not been corrected. Patients with a cognitive impairment such as mental retardation. Patients with psychotic disorders.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Experimental Explicit<br>Cannabis user performs visuo-motor rotation tasks informed of an explicit strategy to maximise performance | Behavioral: Visuo-motor rotation<br>* Participant moves a cursor on a screen by sliding a pen over a digital tablet. Participants perform a center-out movement, aiming to a target that appears over one of a set of eight markers radially distributed. In several block of trials, the mapping of the pen position to the cursor is rotated.<br>Behavioral: Explicit strategy<br>* Participant is provided with an explicit instruction as to how counteract the effects of the visuo-motor rotation via aiming to a marker adjacent target<br>|
| Active Comparator: Control Explicit<br>Healthy subject performs visuo-motor rotation tasks informed of an explicit strategy to maximise performance | Behavioral: Visuo-motor rotation<br>* Participant moves a cursor on a screen by sliding a pen over a digital tablet. Participants perform a center-out movement, aiming to a target that appears over one of a set of eight markers radially distributed. In several block of trials, the mapping of the pen position to the cursor is rotated.<br>|
| Experimental: Experimental Implicit<br>Cannabis user performs visuo-motor rotation tasks without being informed of the explicit strategy | Behavioral: Visuo-motor rotation<br>* Participant moves a cursor on a screen by sliding a pen over a digital tablet. Participants perform a center-out movement, aiming to a target that appears over one of a set of eight markers radially distributed. In several block of trials, the mapping of the pen position to the cursor is rotated.<br>Behavioral: Explicit strategy<br>* Participant is provided with an explicit instruction as to how counteract the effects of the visuo-motor rotation via aiming to a marker adjacent target<br>|
| Active Comparator: Control Implicit<br>Healthy subject performs visuo-motor rotation tasks without being informed of the explicit strategy | Behavioral: Visuo-motor rotation<br>* Participant moves a cursor on a screen by sliding a pen over a digital tablet. Participants perform a center-out movement, aiming to a target that appears over one of a set of eight markers radially distributed. In several block of trials, the mapping of the pen position to the cursor is rotated.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Directional error of hand trajectories towards a target |  | 1 day (a single session) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Reaction times |  | 1 day (a single session) | 
| Intrinsic Motivational Inventory |  | 1 day (a single session) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Learning, Cerebellum