The Effect of Injection Rate of Local Anesthetic in Caesarean Section

Study Overview
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Brief Summary
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This randomized double-blind study aimed to compare the effects of two different subaracnoid lokal anesthetic injection rate in cesarean section. Totally 67 patients were included. The groups were compared in terms of maximum sensory and motor block level, time to reach T6 level, hemodynamic changes and nausea- vomiting saved.

Detailed Description
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A total of 67 patients 18-40 years undergoing cesarean, who were graded as American Society of Anesthesiologists physical status were randomly allocated into two groups, 120-sn injection time (n=34, Group F), 15-sn injection time (n=33, Group S). When the level of the sensory block achieve the T6 level the surgery was let to begin. The groups were compared in terms of hemodynamic values, use of efedrin, the time to achieve sensory block to the T6 level, maximum sensory block level and motor block level.

Official Title
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Does the Injection Rate of Local Anesthetic Affect the Onset of Sensory Block and Incidence of Hypotension in Caesarean Section

Conditions
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Anesthesia, Spinal, Anesthesia, Obstetrical

Intervention / Treatment
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* Other: Local anesthetic injection rate in spinal anesthesia


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Anesthesiologists risk score (ASA) I-II risk status Singleton pregnancy aged Between 18-40 years Exclusion Criteria: Pregnant women with contraindications for spinal anesthesia; Placental anomaly; Hypertension Cardiac disease Vascular disease Hepatic disease Renal disease Hemodynamic instability Spinal deformity; Severe mental retardation Weight < 50 kg or >110 kg; height < 140 cm or > 180 cm Metabolic and Acid-base balance disorders Emergency patients

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Group S:33<br>120-second local anesthesic (% 0,5 Bupivacaine) injection time | Other: Local anesthetic injection rate in spinal anesthesia<br>* Administering intrathecal local anesthetics for all patients according to height and weight.<br>|
| Active Comparator: Group F:34<br>15-second local anesthesic(% 0,5 Bupivacaine) injection time | Other: Local anesthetic injection rate in spinal anesthesia<br>* Administering intrathecal local anesthetics for all patients according to height and weight.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| sensory block | The time to reach the sufficient sensory block and maximum level of sensory block was significantly shorter in Group S | 2 minutes interval | 
| Hypotension | The time to onset of hypotension was significantly shorter in Group F | 2 minutes interval |