From Uncomplicated Alcoholism to Korsakoff's Syndrome

Study Overview
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Brief Summary
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This research project aims to identify factors that contribute to the heterogeneity observed in neuroradiological and neuropsychological signs of chronic alcoholism. The investigators overarching hypothesis is that the heterogeneity of alcoholic consequences on brain structure and metabolism, and cognition is mainly related to individual differences in pattern of alcohol use, gene pool, nutritional status and history of withdrawal symptoms.

Official Title
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From Uncomplicated Alcoholism to Korsakoff's Syndrome: Clinical, Genetic, Neuropsychological and Brain Examinations

Conditions
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Alcoholism, Alcohol Amnestic Disorder

Intervention / Treatment
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* Behavioral: Neuropsychological testing
* Biological: blood draw
* Genetic: genetic testing
* Other: Brain imaging examination


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Completed at least 8 years of education (primary school equivalent) Age-normal corrected hearing and visual acuity Exclusion Criteria: documented loss of consciousness of over 30 minutes, documented compound skull fracture, or clear neurological sequelae of head trauma history of medical or neurological illness or trauma potentially affecting the CNS, e.g., stroke, multiple sclerosis, epilepsy, psychosurgery, insulin coma. active tuberculosis or history of or any malignancy requiring chemotherapy history of schizophrenia or bipolar disorder metal implantation (e.g., pacemakers) or other factors that preclude MRI scanning for subjects selected for the neuroimaging examination meet DSM-IV criteria for current (past 3 months) other Substance Abuse met DSM-IV criteria for other Substance Dependence Have used other substances more than 5 times in the past month

Ages Eligible for Study
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Minimum Age: 21 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Factorial Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: alcoholic patients<br> | Behavioral: Neuropsychological testing<br>* assessment of memory, executive functions and ataxia<br>Biological: blood draw<br>* hepatic markers, red blood markers and vitamin markers<br>Genetic: genetic testing<br>* genes coding for thiamine enzymes (α-ketoglutarate dehydrogenase complex, transketolase et pyruvate dehydrogenase)<br>Other: Brain imaging examination<br>* MRI, DTI and PET examinations<br>|
| Other: korsakoff patients<br> | Behavioral: Neuropsychological testing<br>* assessment of memory, executive functions and ataxia<br>Biological: blood draw<br>* hepatic markers, red blood markers and vitamin markers<br>Genetic: genetic testing<br>* genes coding for thiamine enzymes (α-ketoglutarate dehydrogenase complex, transketolase et pyruvate dehydrogenase)<br>Other: Brain imaging examination<br>* MRI, DTI and PET examinations<br>|
| Other: healthy controls<br> | Behavioral: Neuropsychological testing<br>* assessment of memory, executive functions and ataxia<br>Biological: blood draw<br>* hepatic markers, red blood markers and vitamin markers<br>Genetic: genetic testing<br>* genes coding for thiamine enzymes (α-ketoglutarate dehydrogenase complex, transketolase et pyruvate dehydrogenase)<br>Other: Brain imaging examination<br>* MRI, DTI and PET examinations<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evidence of brain dysfunctioning measured by neuropsychological testing and brain examination(MRI and PET) |  | one year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| treatment outcomes (sobriety or relapse) |  | one year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Behavior, Magnetic Resonance Imaging, Positon Emission Tomography