Continuous Versus Discontinuous Design of Encircling Lesions During Ablation for Atrial Fibrillation

Study Overview
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Brief Summary
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Acute efficacy of point-by-point radiofrequency ablation for pulmonary vein isolation in patients with atrial fibrillation are comparable independantly of the ablation strategy (continous versus discontinuous ablation) under the same condition of power delivery.

Detailed Description
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The number of pulmonary vein isolation (PVI) therapy for atrial fibrillation (AF) is increasing. Durable PVI is cornerstone for long-term freedom of AF. In one previous study continuous ablation was suggested to be more efficient in durable PVI. However, this hypothesis has not been proven in randomized fashion. The current study is to confirm whether continuous versus discontinuous design of encircling lesions are comparable under the same conditions of power delivery. The study design is a two-centre prospective randomized trial to compare the acute efficacy by using the above described approaches.

Official Title
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Acute Efficacy of Point-by-point Radiofrequency Ablation for Pulmonary Vein Isolation in Patients With Atrial Fibrillation: a Randomized Comparison of Continuous Versus Discontinuous Design of Encircling Lesions

Conditions
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Atrial Fibrillation

Intervention / Treatment
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* Procedure: catheter ablation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients undergoing pulmonary vein isolation with radiofrequency catheter ablation for paroxysmal atrial fibrillation treatment. Exclusion Criteria: -

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Discontinuous ablation<br>perform discontinuous ablation of ipsilateral pulmunary veins. | Procedure: catheter ablation<br>* catheter ablation for atrial fibrillation treatment<br>|
| Active Comparator: Continuous ablation<br>perform continuous ablation of ipsilateral pulmunary veins. | Procedure: catheter ablation<br>* catheter ablation for atrial fibrillation treatment<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Combined unsuccessful PVI or PV reconnection | Combined unsuccessfuk PVI after completeing the primary lesion set or PV reconnection during the waiting time | 30 min after ablation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Early pulmunary veins reconnection | Early pulmunary veins reconnection within the first 10 min after PVI | 10 min. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Catheter Ablation, Atrial Fibrillation, Contact Force, Continuous Ablation