Antibacterial Effect of Guava Leaves Extract Mouthwash Compared to Chlorhexidine Mouthwash in High Caries Risk Patients

Study Overview
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Brief Summary
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This trial is to test the antibacterial effect of Guava leaves extract mouth wash compared to Chlorhexidine mouth wash in high caries risk patients. Also salivary pH and patient satisfaction to taste will also be tested.

Detailed Description
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This study is conducted to evaluate the effect of Guava leaves extract mouth wash on anti-bacterial activity against streptococcus mutans, salivary pH and patient satisfaction to taste compared to Chlorhexidine mouth wash. P: Population with high caries risk patients I: Intervention by Guava leaves extract mouthwash C: Control is Chlorhexidine mouthwash O1: The primary outcome is antibacterial activity. O2: The secondary outcome is salivary pH O3: The tertiary outcome is patient satisfaction to taste

Official Title
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Effect of Guava Leaves Extract Mouth Wash on Antibacterial Activity, Salivary pH and Patient Satisfaction Compared to Chlorhexidine Mouth Wash in High Caries Risk Patients: A Randomized Control Clinical Trial

Conditions
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High Caries Risk Patients, Antimicrobial Effect, Salivary pH, Patient Satisfaction to Taste

Intervention / Treatment
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* Drug: Guava leaves extract
* Drug: Chlorhexidine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria High caries risk patients 18-50 years Healthy cooperative patients Males or Females Exclusion Criteria Medically compromised patients Patients with any systemic disease that might affect the salivary flow Allergy to any of the ingredients Patients with physical limitations that might affect normal tooth brushing and mouth rinsing Presence of intraoral infections Currently using any mouth rinse Smokers Use of antibiotics in the previous 30 days

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Guava leaves extract<br>A natural product that is prepared as a mouthwash | Drug: Guava leaves extract<br>* Natural product : The leaves of the guava tree are full of antioxidants, anti-inflammatory agents, antibacterials, and even tannins that can have significant health benefits, from treating stomach troubles to chronic diseases like cancer •<br>* Other names: Psidium guajava;|
| Active Comparator: Chlorhexidine<br>chemical agent Chlorhexidine as a mouthwash | Drug: Chlorhexidine<br>* chemical agent used as a mouthwash against cariogenic bacteria. considered the gold standard<br>* Other names: Chlorhexidine glucnate;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Anti-bacterial effect against streptococcus mutans | Antimicrobial effect against streptococcus mutans: saliva samples collected and total bacterial count measured after agar plates incubating, expressed in colony forming units | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Salivary pH | Saliva samples pH will be measured using digital pH meter to evaluate its efficacy in preventing the action of acidogenic bacteria in high caries risk patients. It displays numerical value. | 3 months |