Dachaihu Decoction Compound and Rhubarb Single Medicine in the Treatment of Acute Pancreatitis

Study Overview
=================
Brief Summary
-----------------
A large number of clinical studies have shown that oral administration, external application or enema of Chinese medicine can promote the recovery of gastrointestinal function and the absorption of pancreatic inflammation. The aims of the study is to explore the application of Dachaihu Decoction Compound (DDC)and Rhubarb Single Medicine (RSM) in the Treatment of Acute Pancreatitis.

Official Title
-----------------
Comparison of Clinical Efficacy of Dachaihu Decoction Compound and Rhubarb Single Medicine in the Treatment of Acute Pancreatitis

Conditions
-----------------
Acute Pancreatitis

Intervention / Treatment
-----------------
* Combination Product: Dachaihu decoction compound
* Drug: Rhubarb single medicine
* Combination Product: Regular therapies


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age from 18 to 65 years old Meet the diagnostic criteria of western medicine for acute pancreatitis, within 48 hours of onset Consent of the subjects, who sign the informed consent form Exclusion Criteria: Women who are pregnant or breastfeeding Acute abdomen such as organic intestinal obstruction, gastrointestinal perforation, purulent cholangitis, etc. Patients with a history of severe heart, liver, kidney and other important organ diseases Patients with mental illness and malignant tumors People who have allergies, or are allergic to a certain drug ingredient

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: DDC(Dachaihu decoction compound) Group<br>Treated with Dachaihu decoction compound and regular therapies | Combination Product: Dachaihu decoction compound<br>* Dachaihu decoction compound includes Bupleurum, Rhubarb, Citrus aurantium, Scutellaria, Pinellia, White Peony, Jujube, Ginger.<br>Combination Product: Regular therapies<br>* Regular therapies, such as fluid therapy, for acute pancreatitis<br>|
| Active Comparator: RSM(rhubarb single medicine) Group<br>Treated with rhubarb single medicine and regular therapies | Drug: Rhubarb single medicine<br>* Rhubarb single medicine<br>Combination Product: Regular therapies<br>* Regular therapies, such as fluid therapy, for acute pancreatitis<br>|
| Other: N Group<br>Treated with regular therapies and without traditional Chinese medicine | Combination Product: Regular therapies<br>* Regular therapies, such as fluid therapy, for acute pancreatitis<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Significant and effective rate | Significant and effective rate after 7 days of treatment | 7 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Acute Pancreatitis, Dachaihu Decoction Compound, Rhubarb Single Medicine