The Effects of Auditory Cueing on Rhythmic Movement and Cortical Excitability in Patients With Parkinson's Disease

Study Overview
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Brief Summary
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Parkinson's disease (PD) is a progressive degenerative disease of central nervous systems deficit. The clinical symptoms of Parkinson's disease include the following motor tasks: difficult in initiating movement, performing rhythmic movement or serial movement, the ability of learning motor movement is also affected. The primary treatment for Parkinson's disease is medical treatment; surgery is used if in need. Rehabilitation such as physical therapy, which aims to improve patient's quality of life and functions, is a non-invasive treatment and value for PD patients. Auditory cue is a technique that widely applied on training patients with Parkinson's disease, and some researches revealed that auditory cueing could improve motor performance. However, the mechanism under this treatment technique is still unknown. This study is to investigate the effect of auditory cueing on rhythmic finger movement in patients with Parkinson's disease. To investigate the mechanism under auditory cueing, neurophysiological data such as motor cortex excitability and blood flow in cortical cortex will be obtained by using Transcranial magnetic stimulation (TMS) and near infrared spectroscopy (NIRS).

Conditions
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Parkinson's Disease

Intervention / Treatment
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* Procedure: rhythmic auditory stimulation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Clinical diagnosis of Parkinson disease Exclusion Criteria: Clinical diagnosis of other neurological diseases Dementia Been diagnosed with any mental illness History of seizures Brain trauma Body with a pacemaker or other electrical stimulator Pregnancy

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: intervention group<br>intervention group which receive auditory cueing while performing movement | Procedure: rhythmic auditory stimulation<br>* Participants perform the finger tapping at the same time give rhythmic auditory stimulation ,and need to execute tapping with auditory stimulation.<br>|
| No Intervention: Control group<br>control group which performing movement after listen to required movement rhythm. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Finger Tapping | Record pre-test and post-test change. | Baseline,45-60 minutes. | 
| Motor evoked potential | Use single-pulse TMS to assess Motor evoked potential change. | Baseline,45-60 minute | 
| Intracortical inhibition & Intracortical facilitation | Use paired-pulse TMS to record pre-test and post-test change. | Baseline,45-60 minutes | 
| Blood oxygen dependent level | Use Near-infrared spectroscopy to record pre-test, in experiment, and post-test change. | Baseline, in experiment,45-60 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Parkinson's disease, Auditory Cueing