Follow-up of Critical COVID-19 Patients

Study Overview
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Brief Summary
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The study will follow COVID-19 patients who required intensive care after 3-6 months and one year after discharge from the ICU with functional level as well as organ function to assess recovery after COVID-19. Blood and urine will be collected for biobanking.

Detailed Description
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The study will follow COVID-19 patients who required intensive care at Uppsala University Hospital and were included in the Uppsala COVID-19 biobank. The patients will be contacted after three to six months for a first follow-up with assessment of functional level in activities of daily life, psychiatric symptoms, neurological symptoms and working capacity as well as specific organ functions. The organ functions will include circulation, respiration, coagulation, immune function and kidney function. In addition, blood and urine will be collected for biobanking.

Official Title
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Uppföljning av Patienter Som intensivvårdats för COVID-19

Conditions
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Coagulation Disorder, COVID19, ARDS, AKI, Circulatory Failure, Inflammatory Response

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: PCR-verified Covid-19 Treated in ICU Exclusion Criteria: Pregnant of breastfeeding

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| COVID-19<br>Patients with PCR-confirmed COVID-19 who were treated in the intensive care unit. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality | Death | Within 90 days after admission to ICU. | 
| Mortality | Death | Within 1 year after admission to ICU. | 
| Renal recovery | Return of renal function measured as CKD stage. | At follow-up three to six months after ICU discharge. | 
| Renal recovery | Return of renal function measured as CKD stage. | At follow-up one year after ICU discharge. | 
| Respiratory recovery | Respiratory function as assessed by a clinician | Three to six months from discharge from ICU | 
| Working capacity | 6 min walk test | Three to six months from discharge from ICU | 
| Quality of life score | Quality of Life assessed using the 36-item short form survey by RAND. | Three to six months from discharge from ICU | 
| Cognitive recovery | Cognitive screening using the Montreal Cognitive Assessment. | Three to six months from discharge from ICU | 
| Frailty | Screening for frailty using the Clinical Frailty Scale-9. | Three to six months from discharge from ICU | 
| Activities of Daily Life | Screening of functional level for Activities of Daily Life using the 5-level EQ-5D. | Three to six months from discharge from ICU | 
| Anxiety | Screening for anxiety using the Generalised Anxiety Disorder 7-item scale. | Three to six months from discharge from ICU | 
| Depression | Screening for depression using the Patient Health Questionnaire 9. | Three to six months from discharge from ICU | 
| Neurological recovery | Neurological function as assessed by a clinician | Three to six months from discharge from ICU | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Corona virus, Acute Kidney Injury, SARS, Vasopressor, Respiratory failure