Incidence of Acute Renal Failure Associated With Iodinated Contrast Agents in Pediatrics

Study Overview
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Brief Summary
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Iodinated contrast media are now frequently used in diagnostic imaging exams, including pediatrics. In adults, the acute renal failure (ARF) associated with contrast agents (CA-AKI) occur in 3-33% of exposed patients, especially as the patient is fragile, has comorbidities or pre-existing renal aggression . In children, the prevalence of this little known disease is probably underestimated. The investigators intend to conduct a prospective epidemiological study, to estimate the impact of the acute renale failure to iodinated contrast agents in pediatrics.

Detailed Description
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Patients will be included those of pediatric emergencies, Hospitalization Unit of Short Duration pediatric, pediatric intensive care and pediatric resuscitation. The acute renale failure will be estimated on the basis of criteria KDIGO (score of kidney disease) group in 2012 to 48 hours a computed tomography (CT) scan with injection of contrast media, based on a change in creatinine clearance of the estimated according to the formula Schwartz revised in 2009 and / or diuresis. Patient characteristics will be identified in order to establish risk factors.

Official Title
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Incidence of Acute Renal Failure Associated With Iodinated Contrast Agents in Pediatrics. Study CANOPY. Prospective Multicenter Study

Conditions
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Acute Renal Insufficiency

Intervention / Treatment
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* Other: CT scan with iodinated contrast agents


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients under 16 years admitted to a participating service Patient receiving an injected CT scan Exclusion Criteria: Prior Inclusion in the study during an earlier review. Opposition of parents. Chronic renal failure or end-stage requiring renal replacement in the long term.

Ages Eligible for Study
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Maximum Age: 16 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| CT scan with iodinated contrast agents<br>Patients under 16 years old and must pass a CT scan with iodinated contrast agents. The following data will be collected in the medical record (creatinine prior to injection, comorbidities and child characteristics, associated treatments and risk factors of acute renal failure, as well as the injection pattern). | Other: CT scan with iodinated contrast agents<br>* Before the CT scan, the investigators with iodinated contrast agents, the following data will be collected in the medical record: creatinine prior to injection, comorbidities and child characteristics, associated treatments and risk factors of acute renal failure, as well as the injection pattern. After the CT scan the investigators will collect the characteristics of the injection type, osmolarity and volume of contrast used and the appearance of a possible allergic reaction. Then 24 and 48 hours and day 7 will collect serum creatinine, urine output and vital replacement therapies may be necessary.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Creatinine | data gathered in the medical file | change from baseline creatinine at 7 days | 
| Diuresis | data gathered in the medical file | change from baseline diuresis at 7 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Readmission | Number of patients with no or having an adverse event during the readmission. | at 7 days | 
| Hospitalization in intensive care | Number of patients with no or having an adverse event during the hospitalization in intensive care. | at 7 days | 
| Renal replacement | Number of patients with no or having an adverse event during the renal replacement. | at 7 days | 
| Death | Number of dead | at 7 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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acute renal insufficiency, Iodinated Contrast Agents, pediatric