Performance of EEG During Emergence Agitation in Nasal Surgery.

Study Overview
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Brief Summary
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The purpose of the study is to evaluate the relationship between perioperative electroencephalogram and emergence agitation in the nasal surgery. Previous studies showed that low frequency band wave activity increased during emergence delirium in pediatric patients. It is still not enough to explain the relationship between emergence agitation and electroencephalogram in adults. Researchers will demonstrate the relationship between parameters related electroencephalogram and emergence agitation in adults undergoing nasal surgery.

Detailed Description
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Researchers use Sedline to perform perioperative EEG measurements of young adult patients undergoing nasal surgery under general anesthesia with sevoflurane. Emergence agitation occurrence and EEG patterns are observed. The researchers record the patient's sex, type of surgery, pre-education on emergence agitation, preoperative hospital anxiety and depression scale (HADS), postoperative pain, amount of analgesics administered in the surgery/recovery room, and PACU time. Investigators check the correlation between EEG and perioperative variables. Investigators also compare EEG and perioperative variables for those who were given an explanation of emergence agitation and those who were not.

Official Title
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The Relationship Between Emergence Agitation and Electroencephalogram in Young Adults Undergoing Nasal Surgery Under General Anesthesia

Conditions
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Nasal Surgery

Intervention / Treatment
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* Other: Nasal surgery


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adult patients aged 19-55 years who are undergoing nasal surgery under general anesthesia using inhalational agent Exclusion Criteria: CNS disease (ex.dementia, stroke, brain tumor, psychological disorder..) unable to communicate general anesthesia history within 6 months disagree to participate in study

Ages Eligible for Study
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Minimum Age: 19 Years
Maximum Age: 55 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Nasal surgery|Nasal surgery under general anesthesia using inhalational agent (sevoflurane)|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| EEG band relative power measured in the frontal lobe | relative power of each brain waves : Original frontal EEG waves using 4 channel sedline (Masimo, Irvine, CA, USA) sensor will processed by FFT(fast Fourier transform). Each band is as follows.: Delta: 1-4 Hz Theta: 4-8 Hz Alpha: 8-13 Hz Beta: 13-30 Hz. | From the cessation of sevoflurane inhalation to the extubation of tracheal tubes | 
| occurrence of emergence agitation | Emergence agitation occurrence : RASS(Richmond Agitation Sedation Score) is 10 scaled (-5 +4) score to assess sedation/agitation level; 0 is a calm state, and a value less than 0 means a sedation state. | From the cessation of sevoflurane inhalation to transfer to the recovery room | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| HADS (Hospital Anxiety and Depression Scale) | A self-assessment scale, brief, clinically useful measure of anxiety and depression symptoms. It can be used to diagnose depression in people with significant physical ill-health. | 1 day before surgery (after admission) | 
| VAS (Visual Analogue Scale) | Using a ruler, it is 11 scaled (0-10) score to assess pain. | during 30 minutes after PACU admission | 
| Effect of preoperative education on emergence agitation | Investigate the relationship between preoperative emergence agitation explanation and occurrence of emergence agitation | up to 6 months after completion of the study | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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general anesthesia, electroencephalogram, emergence agitation, sevoflurane