Glycocalyx Biomarkers in ARDS for Clinical Prognosis and Pulmonary Fibrosis

Study Overview
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Brief Summary
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ARDS is a severe disease in ICU, and could induce high mortality. Glycocalyx is an important matrix construction which covers endothelial cells, it could protect endothelial cells injury and the glycocalyx biomarkers could predict pulmonary injury. Decorin is a member of the small leucine-rich proteoglycan (SLRP) family, contains a single glycosaminoglycan (GAG) chain and a core protein with 12 leucine-rich repeats. In the previous study, decorin is associated with cardiac and liver fibrosis, however, the effects of decorin on ARDS pulmonary fibrosis have not been clarified.

Official Title
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Predictive Value of Glycocalyx Biomarkers in Mechanical Ventilation of Patients With ARDS for Clinical Prognosis and Long-term Pulmonary Fibrosis

Conditions
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ARDS, Human, Endothelial Dysfunction, Mechanical Ventilation Pressure High

Intervention / Treatment
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* Diagnostic Test: Glycocalyx measurement，respiratory mechanics measurement


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age > 18yrs and <80yrs Meet ARDS Berlin definition With mechanical ventilation Exclusion Criteria: have chronic pulmonary disease have use heparin or low molecular heparin or chondroitin sulfuric acid

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Mild ARDS<br>patients have mild ARDS according to Berlin definition | Diagnostic Test: Glycocalyx measurement，respiratory mechanics measurement<br>* ELASA measure glycocalyx, measure plateau pressure, driving pressure<br>|
| Moderate ARDS<br>patients have moderate ARDS according to Berlin definition | Diagnostic Test: Glycocalyx measurement，respiratory mechanics measurement<br>* ELASA measure glycocalyx, measure plateau pressure, driving pressure<br>|
| Severe ARDS<br>patients have severe ARDS according to Berlin definition | Diagnostic Test: Glycocalyx measurement，respiratory mechanics measurement<br>* ELASA measure glycocalyx, measure plateau pressure, driving pressure<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 28 days mortality from patients involved in the study | 28 days mortality from patients involved in the study | 28 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| CT and syndecan-1 to evaluate pulmonary fibrosis | pulmonary fibrosis evaluated by biomarker and CT | 1mon, 3mon and 6 month | 
| pulmonary function test to evaluate pulmonary function | pulmonary function evaluated by pulmonary function test | 1mon, 3mon and 6 month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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ARDS, Endothelial Dysfunction, mechanical ventilation, Glycocalyx, pulmonary fibrosis, mortality