Seroepidemiological Study of SARS-CoV-2 (COVID-19) Infection in Population Subgroups in the State of São Paulo

Study Overview
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Brief Summary
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Seroepidemiological Study of SARS-CoV-2 Infection in Population Subgroups in the State of São Paulo

Detailed Description
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This is a cross-sectional study to estimate the prevalence of antibodies against SARS-CoV-2 is different population subgroups in the State of São Paulo

Official Title
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Seroepidemiological Study of SARS-CoV-2 Infection in Population Subgroups in the State of São Paulo

Conditions
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COVID, SARS-CoV 2

Intervention / Treatment
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* Diagnostic Test: Serological test
* Diagnostic Test: Nasopharyngeal Swab
* Diagnostic Test: Oropharyngeal Swab


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All potential volunteers invited to participate in the study. Exclusion Criteria: All potential eligible participants, but who do not show interest in participating in the study.

Ages Eligible for Study
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Minimum Age: 6 Months
Maximum Age: 100 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| HC-USP<br>Home contacts of health professionals diagnosed with COVID-19 at the Hospital of Clínic of Medicine School of the University of São Paulo | Diagnostic Test: Serological test<br>* IgM and IgG for SARS-CoV-2<br>Diagnostic Test: Nasopharyngeal Swab<br>* PCR for SARS-CoV-2<br>Diagnostic Test: Oropharyngeal Swab<br>* PCR for SARS-CoV-2<br>|
| CORAS<br>Refugees living in the city of São Paulo | Diagnostic Test: Serological test<br>* IgM and IgG for SARS-CoV-2<br>Diagnostic Test: Nasopharyngeal Swab<br>* PCR for SARS-CoV-2<br>Diagnostic Test: Oropharyngeal Swab<br>* PCR for SARS-CoV-2<br>|
| Hemocenter<br>Blood Donors of the Pró-Sangue Hemocenter Foundation of São Paulo | Diagnostic Test: Serological test<br>* IgM and IgG for SARS-CoV-2<br>|
| CPP - Butantan Penitentiary Progression Center<br>Participants of the CPP - Butantan Penitentiary Progression Center | Diagnostic Test: Serological test<br>* IgM and IgG for SARS-CoV-2<br>Diagnostic Test: Nasopharyngeal Swab<br>* PCR for SARS-CoV-2<br>Diagnostic Test: Oropharyngeal Swab<br>* PCR for SARS-CoV-2<br>|
| CHSP - Penitentiary System Hospital Center<br>Participants of the CHSP - Penitentiary System Hospital Center | Diagnostic Test: Serological test<br>* IgM and IgG for SARS-CoV-2<br>Diagnostic Test: Nasopharyngeal Swab<br>* PCR for SARS-CoV-2<br>Diagnostic Test: Oropharyngeal Swab<br>* PCR for SARS-CoV-2<br>|
| SABE (Health, Wellness and Aging)<br>Participants of the SABE Project (Health, Wellness and Aging) | Diagnostic Test: Serological test<br>* IgM and IgG for SARS-CoV-2<br>Diagnostic Test: Nasopharyngeal Swab<br>* PCR for SARS-CoV-2<br>Diagnostic Test: Oropharyngeal Swab<br>* PCR for SARS-CoV-2<br>|
| ILPI - Long-Term Care Institution for the Elderly<br>Residents of the Long-Term Care Institution for the Elderly of Botucatu | Diagnostic Test: Serological test<br>* IgM and IgG for SARS-CoV-2<br>Diagnostic Test: Nasopharyngeal Swab<br>* PCR for SARS-CoV-2<br>Diagnostic Test: Oropharyngeal Swab<br>* PCR for SARS-CoV-2<br>|
| ICR-USP - Children's Institute of HCFMUSP<br>Home contacts of children and adolescents diagnosed with COVID-19, attended at the Children's Institute of HCFMUSP | Diagnostic Test: Serological test<br>* IgM and IgG for SARS-CoV-2<br>Diagnostic Test: Nasopharyngeal Swab<br>* PCR for SARS-CoV-2<br>Diagnostic Test: Oropharyngeal Swab<br>* PCR for SARS-CoV-2<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prevalence of antibodies against SARS-CoV-2 through serological testing | IgM and IgG antibodies against SARS-CoV-2 | 1 month | 
| Frequency of participants with a positive RT-PCR test result for SARS-CoV-2 | Positive RT-PCR test result for SARS-CoV-2 | 1 month |