Delirium Assessment in the Pediatric Intensive Care Unit

Study Overview
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Brief Summary
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Objective: Studies documenting the prevalence of delirium among critically ill children are still rare. Emerging literature from psychiatric specialists reports the prevalence of delirium to be approximately 10% in the pediatric intensive care unit (PICU). This is likely to be an underestimation of the true prevalence, as demonstrated in early adult delirium literature, especially given the absence of validated bedside tools to diagnose delirium in the PICU. The primary aim of this study is to validate the German version of the Pediatric Confusion Assessment Method for the Intensive Care Unit (pCAM-ICU). The secondary aim of the study is to compare validity and reliability of the pCAM-ICU and the Pediatric Anesthesia Emergence Delirium (PAED) Scale.

Official Title
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Delirium Assessment in the Pediatric Intensive Care Unit

Conditions
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Pediatric Delirium

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: pediatric ICU patients Exclusion Criteria: non-German-speaking inability to communicate due to severe hearing loss or brain injury preexisting psychosis mental retardation due to a specific diseases (e.g. M. Crouzon, Kabuki Syndrome, Z.n. Battered Child, Atrogryposes multiplex congenita)

Ages Eligible for Study
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Minimum Age: 5 Years
Maximum Age: 17 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sensitivity of the pediatric confusing assessment method for the intensive care unit (pCAM-ICU) |  | The participants will be followed up in the sample period (1 to 21 days) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Specifity of the pediatric confusing assessment method for the intensive care unit (pCAM-ICU) |  | The participants will be followed up in the sample period (1 to 21 days) | 
| Specifity of the Delirium Rating Scale (DRS) |  | The participants will be followed up in the sample period (1 to 21 days) | 
| Sensitivity of the Delirium Rating Scale (DRS) |  | The participants will be followed up in the sample period (1 to 21 days) | 
| Positive predictive value of the Delirium Rating Scale (DRS) |  | The participants will be followed up in the sample period (1 to 21 days) | 
| Prevalence of delirium | Measured with pediatric confusing assessment method for the intensive care unit (pCAM-ICU), Delirium Rating Scale (DRS) and DSM-IV-criteria | The participants will be followed up in the sample period (1 to 21 days) | 
| Depth of sedation | Measured with Richmond Agitation Sedation Scale (RASS) | The participants will be followed up in the sample period (1 to 21 days) | 
| Quality of Analgesia | Measured by Face Pain Scale, Revised (FPS-R) und the Numeric Analog Scale (NAS) or COMFORT Behavior-Scale. | The participants will be followed up in the sample period (1 to 21 days) |