Thrombin Generation Values and Percutaneous Coronary Intervention Results.

Study Overview
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Brief Summary
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Cardiovascular diseases are the most common cause of death in the western world. Myocardial infarction pathogenesis usually involves the development of an atherosclerotic plaque and thrombus. Past research has shown a correlation between thrombin generation values and ischemic heart disease, however, to our knowledge no investigation has been done into the correlation of thrombin generation and cardiac catheterization results in ischemic heart disease patients. In the current research the investigator will investigate the correlation of thrombin generation values using calibrated automated thrombogram and cardiac catheterization results in active ischemic heart disease patients.

Detailed Description
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The aim of our study is to investigate the correlation of thrombin generation values using calibrated automated thrombogram and cardiac catheterization results in active ischemic heart disease patients. In total 340 patients are planned for inclusion in this trial. After signing an informed consent a blood sample will be obtained from each participant. the investigators will measure the thrombin generation over time in plasma assessed by the calibrated automated thrombogram (CAT). In addition information about the course and results of cardiac catheterization will be collected.

Official Title
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The Correlation Between Thrombin Generation Values and Percutaneous Coronary Intervention Results in Active Ischemic Heart Disease Patients.

Conditions
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Coagulation Disorder, Ischemic Heart Disease, Artery Coronary Stenosis

Intervention / Treatment
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* Device: Calibrated Automated Thrombogram


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Acute coronary syndrome: ST segment elevation myocardial infraction, unstable angina, non ST elevation myocardial infraction or patients presented with chest pain suspect for acute coronary syndrome . planned percutaneous coronary intervention. ability to give Informed consent. Exclusion Criteria: Acute coronary syndrome in the last 6 month prior to current event. thrombophilia pregnancy liver failure or cirrhosis anticoagulant current use active cancer

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: Calibrated Automated Thrombogram|blood samples will be collected . Thrombin generation in platelet-poor plasma will be measured by means of the Calibrated Automated Thrombogram (CAT).|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| significant coronary lesion=>70% stenosis or =>50% stenosis in left main. | coronary arteries significant stenosis evaluated by percutaneous coronary intervention in ischemic heart disease patients | 1 week | 
| syntax score. | coronary arteries significant stenosis evaluated by percutaneous coronary intervention in ischemic heart disease patients | 1 week | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The number of stenotic coronary arteries | the number of stenotic vessels in ischemic heart disease patients | 1 week | 
| Major adverse cardiac events (MACE) | MACE include acute coronary syndrome, cerebral vascular accident , revascularization, death from any cause | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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thrombin generation, calibrated automated thrombogram, ischemic heart disease, Percutaneous Coronary Intervention