An Open-Label Study Of Lamictal In Neurotic Excoriation

Study Overview
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Brief Summary
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The goal of the proposed study is to evaluate the efficacy and safety of Lamictal in neurotic excoriation. Twenty subjects with neurotic excoriation will receive 12 weeks of open-label treatment with Lamictal. The hypothesis to be tested is that Lamictal will be effective and well tolerated in patients with neurotic excoriation. The proposed study will provide needed data on the treatment of a disabling disorder that currently lacks a clearly effective treatment.

Official Title
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An Open-Label Study of Lamictal In Neurotic Excoriation

Conditions
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Neurotic Disorders, Obsessive-Compulsive Disorder

Intervention / Treatment
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* Drug: Lamictal (lamotrigine)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: men and women age 18-65 current diagnosis of neurotic excoriation Exclusion Criteria: unstable medical illness or clinically significant abnormalities on prestudy laboratory tests or physical examination history of seizures myocardial infarction within 6 months current pregnancy or lactation, or inadequate contraception in women of childbearing potential a need for medication other than Lamictal with possible psychotropic effects or unfavorable interactions with Lamictal clinically significant suicidality lifetime history of DSM-IV bipolar disorder type I, dementia, or schizophrenia or any other DSM-IV psychotic disorder current or recent (past 3 months) DSM-IV substance abuse or dependence illegal substance use within 2 weeks of study initiation initiation of psychotherapy or behavior therapy from a mental health professional within 3 months prior to study baseline previous treatment with Lamictal treatment with investigational medication or depot neuroleptics within 3 months, with fluoxetine within 6 weeks, or with other psychotropics within 2 weeks prior to study baseline current treatment with an anti-epileptic medication and patients who have previously been diagnosed with a medical condition that cause skin itchiness (e.g. liver, kidney, and blood diseases, etopic allergies)

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Lamictal (lamotrigine)|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Yale-Brown Obsessive Compulsive Scale Modified for Neurotic Excoriation |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Skin Picking Symptom Assessment Scale (SP-SAS) and the Clinical Global Impression scale |  |  | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Skin, Picking, Pick, Neurotic Excoriation