Magnet Resonance Imaging to Evaluate of Dynamic T2 Preparation Puls by Patients With Shunt or Chronic Obstructive Pulmonary Disease

Study Overview
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Brief Summary
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There is preliminary evidence that a dynamic T2 Preparations Puls sequence by cardiac magnet resonance imaging can differentiate between oxygenated and deoxygenated blood. In adult patients with inborn heart defects this has not yet been researched. Therefore,patients with ventriculoperitoneal shunt, septal and atrio-septal shunt should be examined. Also, patients with chronic obstructive pulmonary disease should be examined. The aim of this study is the validation of a novel magnet resonance sequence in terms of a distinction of oxygenated blood to deoxygenated blood in comparison to invasive method of measuring cardiac catheterization.

Official Title
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Cardiac Magnet Resonance Imaging to Evaluate of Dynamic T2 Preparation Puls by Patient With Shunt or Patients With Chronic Obstructive Pulmonary Disease (COPD)

Conditions
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Dynamic T2 Preparation

Intervention / Treatment
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* Procedure: MRI
* Procedure: coronary angiography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients with atrial septal defect (ASD) or ventricular septal defect (VSD) and COPD written informed consent Exclusion Criteria: patients with ST-elevation contraindication for MRI heavy kidney disease pregnant or breast feeding women

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Arm 1<br>Patients with indication for MRI and coronary angiography | Procedure: MRI<br>* MRI<br>Procedure: coronary angiography<br>* coronary angiography<br>|
| Arm 2<br>Patients with atrioseptal or ventriculoseptal Shunt with indication to coronary angiography | Procedure: MRI<br>* MRI<br>Procedure: coronary angiography<br>* coronary angiography<br>|
| Arm 3<br>Patients with chronic obstructive pulmonary disease with indication to coronary angiography | Procedure: MRI<br>* MRI<br>Procedure: coronary angiography<br>* coronary angiography<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| ventricular volumetry | ventricular volumetry by Cardiac Magnet Resonance Imaging using dynamic T2 Preparation Puls for arithmetical determination of end-systolic volume, end-diastolic volume, ejection fraction, stroke volume and myocardial weight | baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| oxygen partial pressure | Determination of oxygen partial pressure (pO2) during angiography | baseline | 
| carbon dioxide partial pressure | Determination of carbon dioxide partial pressure (pCO2) during angiography | baseline | 
| pH-value | Determination of pH-value od blood during angiography | baseline | 
| Blood gas analysis | Determination of base excess of blood during angiography | baseline | 
| Blood gas analysis | Determination of oxygen partial pressure (pO2), carbon dioxide partial pressure (pCO2), pH-value, base excess | baseline | 
| Major adverse cardiac events | Major adverse cardiac events: death, new indication for angiography, hospitalization | 12 month after procedure | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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MRI, Shunt, COPD, Dynamic T2 Preparation Puls, new sequences, magnet resonance imaging, ventricular septal defect, Atrial septal defect