Neural Mechanisms of Cognitive Assessment and Rehabilitation for Cognitive Decline

Study Overview
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Brief Summary
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This study investigates the neural mechanisms of cognitive function decline, cognitive assessment methods for subjects with mild cognitive dysfunction (Mild cognitive impairment, MCI, or cognitive decline milder than MCI), and the approaches used to improve and restore cognitive function.

Detailed Description
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Cognitive assessment tools are used to assess cognitive function of the subjects, including those aged 60 or older. Functional and structural MRI and EEG are applied to investigate the neural mechanisms of cognitive function decline and effects of methods to improve and restore cognitive function.

Official Title
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Neural Mechanisms of Cognitive Assessment and Rehabilitation for Cognitive Decline

Conditions
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Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD), Aging

Intervention / Treatment
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* Combination Product: multi-modal targeted intervention (e.g., cognitive training, exercise, games)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adults being able to walk at least a block, and Adults with subjective cognitive decline (SCD), or Adults with mild cognitive impairment (MCI), or Adults with normal cognitive function Exclusion Criteria: Clinical diagnosis of dementia Adults who cannot follow the protocal

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Screening
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Control<br>Control group, without specific treatments | |
| Experimental: Cognitive training<br>This group receives treatments to improve cognitive function. | Combination Product: multi-modal targeted intervention (e.g., cognitive training, exercise, games)<br>* The Intervention group will be given recommended interventions tailored to individuals based on their risks (e.g., physical exercise programs, cognitive training, dietary advice, control of blood pressure and cholesterol, healthy diet, control obesity, stop smoking,reduce alcohol excess)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Cognitive function (SCD-9) | The SCD-9 questionnaire is used to assess cognitive function of participants. | Change from Baseline Cognitive test results at 3 months. | 
| Change in Cognitive function (MoCA) | The Montreal Cognitive Assessment test is used to assess cognitive function of participants. | Change from Baseline Cognitive test results at 3 months. | 
| Change in Cognitive function (AD8) | The AD8 test is used to assess cognitive function of participants. | Change from Baseline Cognitive test results at 3 months. | 
| Change in Cognitive function (CDR) | The Clinical Dementia Rating (CDR) test is used to assess cognitive function of participants. | Change from Baseline Cognitive test results at 3 months. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Physical capacity (TUG) | The timed up and go (TUG) test is used to evaluate physical capacity of participants. | Change from Baseline physical capacity test results at 3 months. | 
| Change in Physical capacity (chair standing) | The 30-second chair standing test is used to evaluate physical capacity of participants. | Change from Baseline physical capacity test results at 3 months. |