Study of the Link Between the Slope of the Photomotor Reflex and the Depth of Anesthesia: ILLUMINANS Study

Study Overview
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Brief Summary
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Pupillary diameter monitoring is currently used routinely for assessment of the nociception / antinociception balance during surgery. Pupillary diameter decreases reflexively in response to light flash, called photomotor reflex. The photomotor reflex is described by the latency between the light flash and the beginning of the decay expressed in milliseconds, the slope or decay rate expressed in millimeters per second, and the percentage of variation, corresponding to the ratio between the basal pupil diameter and the minimum diameter reached during the light stimulation. The AlgiScan™ videopupillometer used includes a device for producing a flash light, designed for this purpose. It has recently been shown that the slope (or rate) of pupillary diameter decrease during a light flash varies during anesthesia, independently of any nociceptive stimulus.

Detailed Description
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The hypothesis of this study is the variation of the decay slope of the pupil diameter is proportional to the depth of the anesthesia.

Official Title
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Study of the Link Between the Slope of the Photomotor Reflex and the Depth of Anesthesia. Prospective, Monocentric, Observational Compendium

Conditions
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Neurosurgical Intervention

Intervention / Treatment
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* Other: Collection of datas


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Majors patients Score American Society of Anesthesiologists (ASA) 1 or 2 Managed in the operating theater of the University Hospital of Saint-Etienne for a neurosurgical intervention. Exclusion Criteria: Single or bilateral eye surgery modifying the possibilities of variation of the pupillary diameter Having been asleep under general anesthesia in the 7 days prior to the current surgery History of Parkinson's disease, insulin-dependent or non-insulin-dependent diabetes at a dysautonomic stage or chronic alcoholism at a dysautonomous stage

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients who have a neurosurgical intervention<br>Patients who have a neurosurgical intervention will be included. They will have a collection of datas. | Other: Collection of datas<br>* Collection of datas by videopupillometer results: pupil diameter and variation of the pupillary diameter.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| slope (or rate) of pupil diameter change | To compare the slope (or rate) of pupil diameter change obtained during a standardized 320 Lux light flash and the depth of anesthesia evaluated by the Bispectral Index (BIS™) at different levels of depth of anesthesia. | Day 0 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| latency and the amplitude of pupillary diameter reduction | Correlation between the latency and the amplitude of pupillary diameter reduction obtained during a standardized 320 Lux light flash between the basic pupillary diameter, Pupillary Unrest in Ambient Light (PUAL) and between eyeball movements, and depth of anesthesia as assessed by BIS™. | Day 0 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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photomotor reflex, depth of anesthesia, AlgiScan™, pupil diameter