T2 Weighted Imaging of the Liver With Fast Spin Echo MRI

Study Overview
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Brief Summary
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The purpose of this study is to test two new MRI (magnetic resonance imaging) sequences to see how they compare to previously used imaging sequences as they may improve the quality of abdominal MRI.

Detailed Description
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Approximately 50 patients undergoing routine liver MRI in our practice imaged with one of our 4 clinical scanners will undergo our standard liver MRI protocol with the addition of 2 breath-hold sequences (FSE Flex and eSSFSE) only increasing the scan time by approximately 3 minutes. Data will be retrieved from examinations that have been performed from the patient's electronic imaging file stored in our picture archiving and communication system (PACS). Images will be completely anonymized. No patient identifiers will be available on the images during the analysis. Analyses will include the visual assessment of image quality, presence and severity of imaging artifact and other non-invasive imaging outcomes performed by radiologists blinded to patient information and the type of sequence performed. Data will be presented in a Likert type scale (1=poor, 2=suboptimal, 3=average, 4=above average and 5=excellent) and imaging parameters will be compared using the Wilcoxon sign rank test.

Official Title
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Enhancement of T2 Weighted Imaging of the Liver With Fast Spin Echo Magnetic Resonance Imaging (MRI).

Conditions
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Liver Disease

Intervention / Treatment
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* Device: MRI examinations


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients undergoing routine liver MRI imaged with one of our 4 clinical scanners (MR 750W, General Electric, Milwaukee WI) Exclusion Criteria: Patients not undergoing routine liver MRI
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Imaging- MRI examinations<br>Liver MRI imaging will be performed on 50 patients. | Device: MRI examinations<br>* Consented patients will be required to stay in the MRI scanner to complete the 2 additional sequences once their standard exam is completed.<br>* Other names: Enhanced single shot FSE (eSSFSE);|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The number of abdominal MRI scans deemed improved quality | Data is presented in a Likert type scale (1=poor, 2=suboptimal, 3=average, 4=above average and 5=excellent) and imaging parameters are compared using the Wilcoxon sign rank test. | Regular scan time with one of 4 clinical scanners plus 3 additional minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The number of MRI scans that display severity of imaging artifact | Data is presented in a Likert type scale (1=poor, 2=suboptimal, 3=average, 4=above average and 5=excellent) and imaging parameters are compared using the Wilcoxon sign rank test. | Regular scan time with one of 4 clinical scanners plus 3 additional minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Abdominal-Pelvic MRI (magnetic resonance image), T2W (T2 weighted), FSE Flex (recently developed MRI pulse sequence), Enhanced single shot FSE (fast spin echo).