Transmuscular Quadratus Lumborum Block for Postoperative Pain After Laparoscopic Adrenalectomy

Study Overview
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Brief Summary
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This prospective, randomized control study aims to compare the analgesic effect, satisfaction with anesthesia and analgesia between single-injection QLB (quadratus lumborum block)+general anesthesia (GA) and general anesthesia (GA) alone in patients undergoing laparoscopic adrenalectomy.

Official Title
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Transmuscular Quadratus Lumborum Block for Postoperative Pain After Laparoscopic Adrenalectomy

Conditions
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Pain Management, Nerve Block, Laparoscopic Adrenalectomy

Intervention / Treatment
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* Procedure: single-injection QLB(quadratus lumborum block)
* Procedure: Placebo Control


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 18-70 yrs American Society of Anesthesiologists physical statusⅠ-Ⅲ Undergo laparoscopic adrenalectomy Informed consent Exclusion Criteria: a known allergy to the medications being used for anesthesia coagulopathy or on anticoagulants chronic opioid therapy or history of substance abuse participating in another RCT inability to properly describe postoperative pain to investigators (e.g., language barrier, neuropsychiatric disorder).

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: single-injection QLB (quadratus lumborum block)<br>Single-injection of QLB with local anesthetic is given preoperatively | Procedure: single-injection QLB(quadratus lumborum block)<br>* Inject 0.4ml/kg 0.5% ropivacaine between quadratus lumborum and psoas major muscle Device: The curved (C1-5) probe of Ultrasound Scanner Philips CX50 is used for scan Drug: single dose ropivacaine 0.4ml/kg 0.5% ropivacaine is given immediately after the correct position of needle tip is verified.<br>|
| Placebo Comparator: Placebo control<br>Single-injection of QLB with NS is given preoperatively | Procedure: Placebo Control<br>* Inject 0.4ml/kg saline between quadratus lumborum and psoas major muscle Device: The curved (C1-5) probe of Ultrasound Scanner Philips CX50 is used for scan Drug: single dose 0.4ml/kg 0.9% NS is given immediately after the correct position of the needle tip is verified<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the NRS pain scores on activity 12-hours after surgery | The NRS (a number scale from 0 to 10) is a commonly used pain intensity rating tool | 12-hours after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the pain scores at rest determined by the numeric rating scale (NRS, 0-10) | The NRS (a number scale from 0 to 10) is a commonly used pain intensity rating tool | At 2,4, 8, 12, 24 ,48,72 hours after the surgery | 
| incidence of postoperative nausea and vomiting (PONV) |  | within 24 postoperative hours | 
| ambulation time |  | within 5 days after surgery | 
| time of recovery of bowel movement | defined as the time to first flatus | within 5 days after surgery | 
| postoperative length of hospital stay |  | up to 2 weeks after surgery | 
| patient's satisfaction of anesthesia and analgesia | use the Chinese version of Bauer questionnaire to assess the patient satisfaction of anesthesia | 48 hours after surgery | 
| the NRS pain scores on activity after surgery | The NRS (a number scale from 0 to 10) is a commonly used pain intensity rating tool | At 2,4, 8, 24 ,48,72 hours after the surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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transmuscular quadratus lumborum block, adrenalectomy