Effects of a 12-week Combined Exercise Program on Ghrelins in Obese Adolescent Girls

Study Overview
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Brief Summary
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This study aimed to explore the effects of a 12-week combined exercise on ghrelin O acyl transferase, acylated ghrelin and desacylated ghrelin levels in obese girls.

Detailed Description
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Little is known about on ghrelin O acyl transferase (GOAT), acylated ghrelin (AG) and desacylated ghrelin (DAG) levels during long-term exercise in adolescent population. Our previous study showed that combined exercise program in overweight children increases DAG with unchanged AG. This study aimed to explore the effects of a 12-week combined exercise on GOAT, AG, and DAG in obese girls.

Official Title
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Effects of a 12-week Combined Exercise Program on Acylated and Desacyl Ghrelin, and Ghrelin O Acyl Transferase in Obese Adolescent Girls

Conditions
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Ghrelin

Intervention / Treatment
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* Other: Combined exercise program
* Other: Control


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: girls between 16 and 18 years being classified as being overweight or obese defined with the 85th percentile of body mass index or above based on the 2007 growth chart for Korean children aged 2-18 years. After consultation with a physician, they were required to be considered physically healthy enough to engage in regular exercise after school. Exclusion Criteria: participation in any weight-management programme in the past 6 months engagement in other exercise programs except for regular physical education at school smoking amenorrhea for consecutive 2 months or more being treated for hereditary diseases, mental disorder, hypertension, diabetes mellitus, or musculoskeletal impairments taking any medication or supplements for weight control

Ages Eligible for Study
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Minimum Age: 16 Years
Maximum Age: 18 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Exercise group<br>Exercise group who performed a combined exercise and 300 kcal/day deficit diet during 12 weeks. | Other: Combined exercise program<br>* Combined exercise programme, consisting of warm-up, aerobic exercise, resistance training, and cool-down, 3 days a week after school for 50 minutes from 17;30 under supervision by a trainer plus 300 kcal deficit diet<br>|
| Placebo Comparator: Control group<br>Control group who performed 300 kcal/day deficit diet during 12 weeks. | Other: Control<br>* 300 kcal deficit diet only<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| body fat percent | Changes in body fat percent during 12 weeks | Change from baseline body fat percent at 12 weeks | 
| acylated ghrelin | Changes in concentrations of acylated ghrelin during 12 weeks | Change from concentrations of baseline acylated ghrelin at 12 weeks | 
| desacylated ghrelin | Changes in concentrations of desacylated ghrelin during 12 weeks | Change from concentrations of baseline desacylated ghrelin at 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| ghrelin O acyl transferase | Changes in concentrations of ghrelin O acyl transferase during 12 weeks | Change from baseline concentrations of ghrelin O acyl transferase at 12 weeks |