The Efficacy in Treatment of Female Pattern Hair Loss Using 5% Minoxidil Solution Combinded With Zinc Supplement

Study Overview
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Brief Summary
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Zinc supplement is a popular trace element gave to Female pattern hair loss (FPHL) patient. But the type of patient, efficacy, and side effect in detail of zinc supplement are not well characterized. The purpose of this study is to determine efficacy and side effect of chelated zinc in FPHL who using 5%minoxidil solution.

Detailed Description
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5%minoxidil solution is standard treatment for Female pattern hair loss (FPHL) patient. We gave 15mg chelate Zinc / Placebo drug to patient as an additional trace element. Then measure growth of hair by Global photograph, Microscope hair count, micrometer and record case and side effect during 10 months of treatment.

Official Title
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A Pilot Study of the Efficacy in Treatment of Female Pattern Hair Loss Using 5% Minoxidil Solution Combinded With Oral Chelated Zinc Supplement

Conditions
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Female Pattern Alopecia

Intervention / Treatment
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* Drug: 15 mg Chelate zinc supplement
* Drug: Placebo drug supplement


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Female Pattern Hair Loss ( Ludwig classification grade 1 and 2 ) Exclusion Criteria: Underlying disease ; Anemia, Diabetes, chronic alcoholism, previous gastrointestinal surgery, short bowel syndrome, Crohn's disease, digestive disorder, hypo/hyperthyroidism, sickle cell disease, autoimmune disease, iron deficiency Psychologic disorder trichotillomania Diet control Pregnancy or lactation On supplement diet within 3 month prior to trial

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Chelate zinc suppliment<br>15mg Chelate zinc suppliment : additional to standard 5% minoxidil | Drug: 15 mg Chelate zinc supplement<br>* 15 mg Chelate zinc additional to standard 5% minoxidil<br>* Other names: zinc, Zn;|
| Placebo Comparator: Placebo drug<br>Placebo drug to compare with 15mg chelated Zn : additional to standard 5% minoxidil | Drug: Placebo drug supplement<br>* Placebo drug instead of Zinc supplement<br>* Other names: starch;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Compare clinical improvement before and after treatment | Measure clinical by Global photographic view using 7 point scale. Review picture by 2 dermatologist | 6 month | 
| Compare hair density before and after treatmen | Measure Hair density by microscope photo of area 1 cm2. Conut number of hair in photo. | 6 month | 
| Compare average hair shaft diameter before and after treatment | Compare average hair shaft diameter before and after treatment Measure hair shaft diameter using electronic outside micrometer. | 6 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of pateint with Side effect | Using side effect record form to record side effect from treatment Count number of pateint with side effect. | 6 month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Female pattern hair loss