The Effect and Prognosis of Different Operations on Varicocele - a Single-center Clinical Study

Study Overview
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Brief Summary
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The purpose of this study is to determine whether high ligation of spermatic vein by open operation and microsurgery for patients with are effective in the treatment of varicocele and to determine which surgical option is better.

Official Title
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The Effect and Prognosis of Different Operations on Varicocele - a Single-center Clinical Study

Conditions
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Varicocele; Male Infertile;Varicocelectomy

Intervention / Treatment
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* Procedure: open operation
* Procedure: microsurgery


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 1.infertile patient suffering from varicocele 2.severe varicocele patient with obvious symptoms 3.adolescents suffering from severe varicocele with or without orchiatrophy Exclusion Criteria: 1.varicocele patient with abdominal infection 2.varicocele patient who has massive adhesion of pelvic tissue due to pelvic surgery history 3.mild varicocele 4.varicocele patient has no obvious symptoms if has have born children, suffer from idiopathic azoospermia，or their partner can't bear children

Ages Eligible for Study
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Minimum Age: 10 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: open operation<br>high ligation of spermatic vein by open operation | Procedure: open operation<br>* high ligation of spermatic vein by open operation<br>|
| Experimental: microsurgery<br>high ligation of spermatic vein by microsurgery | Procedure: microsurgery<br>* high ligation of spermatic vein by microsurgery<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the quality of semen and the level of sexual hormone | The semen analyses and were sexual hormones determinations conducted before and three and six months after surgery.Then the quality of semen and the level of sexual hormone before and after surgery were compared. | before and three and six months after surgery | 
| complications | the complications such as recurrence, hydrocele,orchiatrophy and wound infection were assessed one, three and six months postoperation. Color doppler ultrasonography and physical examination are the main methods to assess the complications | one, three and six months postoperation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| If there was pain, visual analogue scale,Numerical rating scale and verbal rating scale would be used to evaluate pain intensity. pain intensity | If there was pain, visual analogue scale,Numerical rating scale and verbal rating scale would be used to evaluate pain intensity. | before and one,three and six months after surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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varicocele; male infertile;varicocelectomy