Tiotropium in Patients With Tuberculosis (TB) Destroyed Lung

Study Overview
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Brief Summary
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The aim of this study to evaluate clinical efficacy of tiotropium in patients with airflow obstruction due to Tuberculosis (TB) destroyed lung.

Detailed Description
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Tuberculosis can cause lung parenchymal destruction, volume loss, secondary bronchiectasis. Patients with TB destroyed lung complain chronic respiratory symptoms, such as chronic cough, sputum, dyspnea, exercise intolerance, and acute exacerbations. Some of them have chronic airflow obstructions on pulmonary function tests, similar to those of smokers. Previous large randomized controlled trials, targeting patients with smoking related moderate to severe COPD,demonstrated that tiotropium improved quality of life and respiratory symptom with tolerable long-term safety. The investigators want to evaluate whether tiotropium can improve chronic respiratory symptom,an lung function in patients with COPD due to TB destroyed lung.

Official Title
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Clinical Efficacy of Tiotripium in Patients With Airflow Obstruction Due to TB Destroyed Lung

Conditions
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Lung Disease, Obstructive, Tuberculosis

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: previous pulmonary tuberculosis history never smoker or light smoker (<10 pack-year) destruction of lung parenchyme, lung volume loss,secondary bronchiectasis due to tuberculosis in chest radiographs or chest CT, confirmed by board-certificate radiologist airflow obstruction confirmed by pulmonary function test, FEV1/FVC <70% Exclusion Criteria: patients do not agree with study enrollment patients with active tuberculosis or current antituberculous medication patients under chemotherapy or other immunosuppressant therapy such as glucocorticoid. active infection such as pneumonia, tuberculosis patients who are illiterate patients with dementia pregnant or to be pregnant previous lung resection surgery history

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Tiotropium in TB destroyed lung<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| St-George respiratory questionnaire(SGRQ) |  | 6 months after initiation of tiotropium once-daily inhalation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| lung function |  | 6mo after initiation of tiotropium once-daily inhalation | 
| cough VAS |  | 6mo after initiation of tiotropium once-daily inhalation | 
| adverse reaction of tiotropium |  | 6 months after initiation of tiotropium once-daily inhalation | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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tiotropium, COPD, tuberculous destroyed lung