Effects of Standing on Glycemia in Prediabetic Adults

Study Overview
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Brief Summary
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The study is a crossover, pilot trial examining the acute effects of standing on blood sugar in prediabetic, working adults. Participants will complete oral glucose tolerance testing, once while sitting and once while standing. They will also wear a continuous blood sugar monitor once while sitting at their desk for a week and once while using their desk as a sit-stand desk with a goal of standing intermittently for at least half of the work day. Physical activity levels will be measured with an accelerometer. The primary study hypothesis is that blood sugar will differ between the sitting and standing conditions for each of the tests performed.

Official Title
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Acute Effects of Standing on Glycemia in Prediabetic Adults: A Pilot Study

Conditions
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Prediabetes

Intervention / Treatment
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* Other: Sitting OGTT
* Other: Standing OGTT
* Other: Sitting CGM
* Other: Standing CGM


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Fasting blood glucose >100 mg/dl Employed full-time working at least 35 hours/week Able to safely begin a light physical activity program Exclusion Criteria: Heart disease Renal disease Peripheral neuropathy Retinopathy PAD Lower limb amputation pregnancy active substance abuse current smoker psychiatric disorder severe visual impairment immune-compromised individuals, enrollment in a physical activity study use of insulin or an insulin pump

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Sitting Oral Glucose Tolerance Test<br>An OGTT is performed while the subject sits at their desk for the entire 2-hour period. 5 blood sugar measurements are taken and a 75g dextrose beverage is consumed following the first, baseline blood sugar reading. The blood sugar is then measured every 30 minutes up to 120 min. | Other: Sitting OGTT<br> <br> Other: Standing OGTT<br> <br> |
| Experimental: Standing Oral Glucose Tolerance Test<br>The participant stands at their desk for the duration of the 2-hour blood sugar test. The same procedure is performed as in the sitting condition. | Other: Sitting OGTT<br> <br> Other: Standing OGTT<br> <br> |
| Placebo Comparator: Sitting Continuous Glucose Monitor<br>A continuous blood glucose monitor is worn for 5 days while at work. In the sitting condition the participant only sits at their desk for the duration of the week. Blood sugar is monitored 4 times per day to calibrate the CGM and an accelerometer is worn to track physical activity. | Other: Sitting CGM<br> <br> Other: Standing CGM<br> <br> |
| Experimental: Standing Continuous Glucose Monitor<br>Participants are instructed to stand intermittently for at least half of their work day during this 5 day period. Blood sugar is monitored and physical activity is tracked with an accelerometer. | Other: Sitting CGM<br> <br> Other: Standing CGM<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood sugar area under the curve | The area under the curve following the 2 hour blood sugar tests. | 2 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Accelerometer counts | Accelerometer counts in the 4 testing conditions. | 4 hours and 2 5 day periods | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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prediabetes, physical inactivity, sedentary, standing