Combined Resistance and Aerobic Exercise is Better Than Resistance Training Alone to Improve Functional Performance of Hemodialysis Patients - Results of a Randomized Trial

Study Overview
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Brief Summary
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This is a randomized trial with participants recruited from one dialysis unit of a Brazilian university hospital. Hemodialysis patients were assigned to receive the resistance exercise combined with an aerobic training or the resistance training alone for a period of 10 weeks. The functional performance of patients was assessed before and after the intervention through the six-minute walk test (6MWT). The difference over time of the 6MWT was compared between the groups through multivariate linear regression. Thirteen patients were allocated for each group of intervention. The difference in distance walked before and after intervention in the combined training group was of +39.7 (61.4) meters, and this difference in the resistance training group was of -19.2 (53.9) meters, p=0.01. In multivariate analysis with adjustment for age, skin color, gender, hematocrit, time since starting dialysis, Kt/V and baseline values of 6MWT, the type of training remained significantly associated with the amount of increase in walked distance. Although the best protocol of exercise for patients on dialysis is not yet clear, in the investigators sample of hemodialysis patients the combination of aerobic and resistance training was more effective to improve functional performance.

Official Title
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Combined Resistance and Aerobic Exercise is Better Than Resistance Training Alone to Improve Functional Performance of Hemodialysis Patients - Results of a Randomized Trial

Conditions
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End Stage Renal Disease

Intervention / Treatment
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* Behavioral: exercise training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: to be on hemodialysis therapy for longer than 3 months to be already included in the resistance training protocol during dialysis to receive erythropoietin for the treatment of anemia hemoglobin level greater than 9.0 g/dL to be able to maintain sitting and standing balance and ambulatory without assistance. Exclusion Criteria: symptomatic ischemic heart disease recent myocardial infarction of less than 6 months uncontrolled hypertension pericardial or pleural friction rub aortic stenosis active musculoskeletal lower-extremity problem, or history of vertebral fracture caused by osteoporosis patients were also excluded if they participated in formal organized exercise programs outside the dialysis unit.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: combined aerobic and resistance training<br> | Behavioral: exercise training<br> <br> |
| Active Comparator: resistance training alone<br> | Behavioral: exercise training<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| physical performance |  | 10 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| dialysis adequacy (KtV) |  | 4/8/10 weeks |