The Cyclocapnic Method for Measurement of Chemosensitivity

Study Overview
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Brief Summary
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We aim to test our method for measuring chemosensitivity (the ventilatory response to a change in carbon dioxide), which uses sinusoidal carbon dioxide stimuli. Hypotheses: Carbon dioxide sensitivity is dependent on the cycle time over which we administer the gas (frequency). Chemoreflex gain decreases as deadspace increases.

Detailed Description
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We will apply a new method for the measurement of chemosensitivity (how sensitive a person is to changes in carbon dioxide), which is one of the principle determinants of whether people with heart failure develop abnormal breathing patterns We have shown in a pilot study that administering sinusoidal patterns of inspired carbon dioxide produces similar sinusoidal responses in ventilation. We aim to test our method for measuring chemosensitivity, which uses sinusoidal carbon dioxide stimuli (similar to those that drive the oscillations in ventilation found in periodic breathing). We aim to show that how the cycle time of carbon dioxide administered affects the resulting ventilatory oscillations and therefore that when measuring the chemoreflex clinically, it is important to deliver carbon dioxide stimuli that replicate the cycle time of oscillations in carbon dioxide seen in periodic breathing (typically approximately one minute).

Official Title
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Developing an Improved Measure of Chemosensitivity for the Study of Periodic Breathing in Heart Failure: the Cyclocapnic Method

Conditions
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Periodic Breathing, Heart Failure

Intervention / Treatment
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* Other: carbon dioxide


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Heart failure subjects with stable cardiorespiratory control to be recruited from our institution's specialist heart failure clinic. Normal healthy volunteers, with normal systolic function. Exclusion Criteria: We will exclude patients with chronic respiratory disease (every patient will have formal lung function testing on entrance into the study) or unstable coronary artery disease (myocardial infarction or unstable angina within the past 3 months). In addition any subjects receiving treatment with morphine and derivatives, theophylline, oxygen, benzodiazepines or acetazolamide will be excluded as these affect chemosensitivity.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: carbon dioxide|sinusoidal carbon dioxide administration|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Chemoreflex gain as measured by cyclocapnic method |  | every minute | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Periodic breathing, Heart Failure, Chemoreflex, Chemosensitivity