Latent Tuberculosis in Second Generation Immigrants From High Risk Countries Compare to Low-risk Young Israeli Adults

Study Overview
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Brief Summary
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The aim of study is to evaluate the prevalence of latent TB in second generation immigrants from countries with high incidence of tuberculosis (above 20 of 100,000) compare to the control native Israelis without a family member who was born in a country with high incidence of tuberculosis. Using study questionnaire IGRA and tuberculin skin test the investigators expect that the second generation immigrants group will have more positive IGRA test than the control native group.

Official Title
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Better Identification of Latent Tuberculosis Infection Among Israeli Young Adults by Comparison Skin Tests and Interferon Gamma Releasing Assays (IGRA)

Conditions
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Latent Tuberculosis

Intervention / Treatment
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* Procedure: Answering the study Questionnaire and blood sampling for Interferon gamma release assay (IGRA)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 18-25 Men and women Second generation immigrants from countries with high incidence of tuberculosis (above 20 of 100,000). Native Israelis without a family member who was born in a country with high incidence of tuberculosis. Exclusion Criteria: Prior contact with a tuberculosis patient Working (more than a month) in high risk setting such as health care workers, working with immigrants from countries with high incidence of tuberculosis. HIV infection and any immunodeficiency condition. Recent live-virus vaccination Acute infectious disease Prior serious reaction to tuberculin skin test Pregnancy

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 25 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Second generation immigrants from high TB incidence countries<br>Answering the study Questionnaire and blood sampling for Interferon gamma release assay (IGRA). | Procedure: Answering the study Questionnaire and blood sampling for Interferon gamma release assay (IGRA)<br> <br> |
| Other: Native Israelis<br>Answering the study Questionnaire and blood sampling for Interferon gamma release assay (IGRA). | Procedure: Answering the study Questionnaire and blood sampling for Interferon gamma release assay (IGRA)<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Interferon gamma release assay ( IGRA) |  | Up to 3 months after tuberculin skin test | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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immigration, latent tuberculosis, tuberculin skin test, Interferon gamma release assay