Cognitive Consequences of an Activation of the Cortical Drive to Breath (VENTIPSY)

Study Overview
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Brief Summary
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The purpose of the study is to measure the negative cognitive consequences of the ventilation under pathological or experimental cortical drive to breath.

Detailed Description
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Cognitive capacities are measured on healthy subject submitted to inspiratory threshold loading, patients treated by chronic mechanical ventilation due to suffering Ondine syndrome or amyotrophic lateral sclerosis. The spontaneous breathing is compared to NIV breathing or inspiratory threshold loading.

Official Title
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Cognitive Consequences of an Activation of the Cortical Drive to Breath

Conditions
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Ondine Syndrome, Healthy, Amyotrophic Lateral Sclerosis

Intervention / Treatment
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* Other: Neuropsychological tests


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adults and non-vulnerable adults Fluent in French Exclusion Criteria: For patients: Total ventilatory dependency Coexistence of an other respiratory disease Alcohol and /or psychotropic consumption during the last 24 hours One or more episodes of acute respiratory failure during the past 6 months Serious cognitive deficiency or presence of fronto temporal dementia End-stage disease No affiliation to social security For healthy volunteers: Existing respiratory disease Alcohol and /or psychotropes consumption during the last 24 hours Tobacco smoking more than 2 pack-years Sleep deprivation Serious cognitive deficiency No affiliation to social security

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Healthy<br>40 healthy subjects, during quiet breathing and under an inspiratory load (inspiratory threshold loading) | Other: Neuropsychological tests<br>* A battery of tests to evaluate the overall cognitive performance of the subjects (memory, executive, attentional or instrumental functions)<br>|
| Ondine syndrome<br>12 patients presenting with central hypoventilation syndrome or Ondine's curse syndrome, during spontaneous breathing and with Non Invasive Ventilation | Other: Neuropsychological tests<br>* A battery of tests to evaluate the overall cognitive performance of the subjects (memory, executive, attentional or instrumental functions)<br>|
| Amyotrophic Lateral Sclerosis<br>30 patients presenting with Amyotrophic Lateral Sclerosis during spontaneous breathing and with Non Invasive Ventilation | Other: Neuropsychological tests<br>* A battery of tests to evaluate the overall cognitive performance of the subjects (memory, executive, attentional or instrumental functions)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Score at PASAT (Paced Auditory Serial Addition Test) | Performances will be assessed by counting the number of good and wrong answers, and comparing it in two conditions : spontaneous breathing (SB) versus inspiratory resistive loading for healthy subjects, and SB versus non invasive ventilation for patients. | 3 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Oxygen saturation changes | Modifications of oxygen saturation measured using a saturometer placed on the subject's finger. | 3 hours |