Pain Sensitivity Questionnaire and Postoperative Opioid Requirement

Study Overview
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Brief Summary
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This study aims to investigate the potential association between pain sensitivity questionnaire score, the severity of postoperative pain, and postoperative analgesic requirement in patients with open colorectal cancer surgery. This information may be used to guide the optimal postoperative pain management, and ultimately improve patient's quality of life.

Detailed Description
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We plan to investigate the predictive ability of the PSQ as well as experimental parameters of pain sensitivity using electronic algometer and other known risk factors for postoperative pain in 100 patients scheduled for open colorectal cancer surgery. The following items are investigated before surgery; Age, sex, level of education, type of surgery, past surgical history, presence of chronic pain, the expected maximal pain score (VAS) after surgery, Pain catastrophizing scale, anxiety scale (HADS-A), Pain sensitivity questionnaire, and pain threshold measured by electronic algometer. The total opioid consumption is investigated for 24 and 48 hours after surgery. In addition, the severity of postoperative pain is measured by the 11-point VAS at 24 and 48 hours after surgery. Patient satisfaction with postoperative pain control is also investigated at 48 hours after surgery using the 7-point patient's satisfaction scale.

Official Title
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A Cohort Study on Association Between Pain Sensitivity by Pain Sensitivity Questionnaire and Postoperative Opioid Requirement

Conditions
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Postoperative Pain

Intervention / Treatment
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* Device: Electronic digital pressure algometer
* Diagnostic Test: Pain sensitivity questionnaire


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 18 years or above Patients scheduled for open colorectal cancer surgery under general anesthesia ASA status I-III Ability to read and understand the information sheet, questionnaires, and the - consent form Patients scheduled for using IV-PCA after surgery Exclusion Criteria: Unable to read and understand the information sheet, questionnaires, and the consent form Severe medical or psychological diseases Patients with preoperative chronic pain

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Screening
Intervention Model: Single Group Assignment
Interventional Model Description: Prospective observational study
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: study group<br>The following tests will be performed on the study subjects. Pain catastrophizing scale Hospital Anxiety and Depression scale-Anxiety Subscale (HADS-A) Pain sensitivity questionnaire Pain pressure threshold using electronic digital pressure algometer | Device: Electronic digital pressure algometer<br>* Evaluation of pain threshold using an algometer is conducted one day before surgery. The pressure of the plunger of algometer is applied vertically to the patient's right thenar muscle belly at a speed of 10 N/sec by the tester. Then the tester removes the algometer when the patients start to feel pain and record the pressure recorded on the algometer.<br>* Other names: electronic digital pressure algometer (FGN-20B, Shimpo, Kyoto, Japan);Diagnostic Test: Pain sensitivity questionnaire<br>* Evaluation of pain threshold using the Korean-version pain sensitivity questionnaire is conducted one day before surgery.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Total fentanyl consumption during 24 hours | postoperative fentanyl consumption (mcg) via IV patient controlled analgesia | postoperative 24 hours | 
| Total fentanyl consumption during 48 hours | postoperative fentanyl consumption (mcg) via IV patient controlled analgesia | postoperative 48 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative pain score | 11-pointed NRS pain score at resting/coughing/movement NRS (0-10): 0, no pain; 10, worst pain imaginable | postoperative 24, 48 hours | 
| Patient satisfaction for postoperative pain management | 7-pointed likert scale (very satisfied-somewhat satisfied-satisfied-neutral-dissatisfied-somewhat dissatisfied-very dissatisfied) | postoperative 48 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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postoperative pain, pain sensitivity