Bipolar Research Study Using MR Imaging

Study Overview
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Brief Summary
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In this proposal, the investigators will focus on subcortical gray and white matter structures commonly found to be abnormal in schizophrenia. Thus, the investigators will evaluate the volume and shape of the hippocampus, thalamus and basal ganglia, as well as measures of structural integrity of the corpus callosum and its various subregions.

Detailed Description
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There are relatively few studies evaluating brain structure in bipolar disorder (BD), the results of which have been largely inconsistent, both in terms of what abnormalities are present in BD and whether they show any similar abnormalities to those found in schizophrenia. One possibility that might explain the varying degree of reported similarity in structural findings in schizophrenia and BD is that there might be effects of BPD diagnostic subtype associated with brain structure. One viewpoint that contrasts schizophrenia and BD considers psychotic (PBD) to differ from non-psychotic (NPBD) subtypes in terms of shared pathophysiology with schizophrenia. PBD has been reported as being of special interest, as it shares symptomatic overlap with schizophrenia, runs in families, shares a chromosomal linkage to the 13q13-32 and 22q12 with schizophrenia, shows similar increases in dopamine receptor Bmax induced by [c-11] N-methylspiperone positron emission tomography and similar working memory impairments as in schizophrenia. If PBP and NPBP are associated with different forms of brain pathology, then merging the two entities into a single bipolar group might obscure relevant anatomic differences if these occur primarily in only one group. In this proposal, the investigators will focus on subcortical gray and white matter structures commonly found to be abnormal in schizophrenia. Thus, the investigators will evaluate the volume and shape of the hippocampus, thalamus and basal ganglia, as well as measures of structural integrity of the corpus callosum and its various subregions.

Official Title
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Neuromorphometry of Psychosis in Bipolar Disorder

Conditions
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Bipolar Affective Disorder

Intervention / Treatment
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* Other: MRI scanning


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: between the ages of 18-30 diagnosed with Bipolar Disorder Exclusion Criteria: history of head injury unstable medical condition

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 30 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Bipolar Diagnosis<br>Individuals identified as having a Bipolar Diagnosis with a manic episode | Other: MRI scanning<br> <br> |
| Control<br>Individuals identified as not having a major psychiatric diagnosis | Other: MRI scanning<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| subcortical grey and white matter structures | Evaluation of the volume and shape of the hippocampus, thalamus and basal ganglia, as well as measures of structural integrity of the corpus callosum and its various subregions. | within one month of study enrollment | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Bipolar Disorder, Magnetic Resonance Imaging (MRI) scanning