Registry of Patients With Takotsubo Syndrome

Study Overview
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Brief Summary
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Takotsubo syndrome is a condition which mimics acute myocardial infarction, and is diagnosed in 1.5% to 2.2% of patients referred to hospital with suspected acute coronary syndrome. It is also known as broken heart syndrome, takotsubo cardiomyopathy, stress cardiomyopathy and apical ballooning cardiomyopathy, among other names. The pathogenesis of this disorder is not well understood. Possible mechanisms include catecholamine excess, coronary artery spasm, microvascular dysfunction, among others. This is a multicenter, nation-wide, observational study of patients who were previously diagnosed with takotsubo syndrome. The investigators aim to use this registry to help plan and carry out further studies and to improve understanding of the pathophysiologic mechanisms of this syndrome. In addition participants will be followed for events, and to monitor quality of life and stress.

Detailed Description
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Patients are eligible to participate if they are aged 18 years or older and carry a physician confirmed diagnosis of takotsubo syndrome. Patients with a history of takotsubo syndrome will be identified via physician referral, Epic search and patient self-referral. Patients may register directly through our registry website at www.nyulmc.org/brokenheartstudy or via direct contact with the study team via e-mail or telephone. Following completion of a research authorization form and collection of medical records, study team will confirm the diagnosis of takotsubo syndrome. Data will be collected including contact information, medical history, data on the takotsubo event(s) including physician records and all relevant imaging. Participants will also be asked quality of life questionnaires and will be followed every 4 months for events.

Official Title
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NYU Takotsubo (Broken Heart Syndrome) Registry

Conditions
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Takotsubo Cardiomyopathy, Broken Heart Syndrome, Tako-tsubo Cardiomyopathy

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Physician diagnosis of takotsubo syndrome Age>18 years Exclusion Criteria: - Lack of capacity to provide informed consent

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 110 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Major Adverse Cardiac Events | Medical record review and patient report of repeat takotsubo event, MI, heart failure, unstable angina, chest pain ER visit, cardiovascular death, stroke | up to 10 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quality of life assessed using the Patient Reported Outcome Measurement Information System (PROMIS-10) questionnaire | Measure of quality of life | every four months up to 10 years | 
| Anxiety is assessed using the Hospital Anxiety and Depression Scale (HADS-A) | Measure of anxiety | every four months up to 10 years | 
| Depression assessed using the Patient Health Questionnaire (PHQ-9) | Measure of depression | every four months up to 10 years | 
| Perceived stress is measured using the Perceived Stress Scale (PSS-10) | Measure of perceived stress | every four months up to 10 years |