Semmelweis Sport Study

Study Overview
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Brief Summary
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The aim of the present proposal is to investigate the development of distinct morphological, functional, biochemical and molecular aspects of short- and long-term sport-induced changes in the heart, to get a better understanding on the (patho)physiology of athlete's heart. The main goal of our research is to deepen our knowledge on the proper differentiation between beneficial (physiological) and harmful (pathological) consequences of professional sport, thereby effectively preventing potential cardiovascular complications of athletes.

Detailed Description
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CLINICAL METHODS Sport specific questionnaire, patient history and physical examinations - In our detailed questionnaire, specific information is collected about quantity and quality of training, personal and family history and presence of sport specific and general symptoms. Laboratory biochemical examination - Besides the regular routine laboratory parameters, several specific parameters associated with physical exercise are planned to be measured, such as cardiac biomarkers. 12-lead ECG - Resting standard 12-lead digital ECG will be recorded. Extended analysis will be performed according to the latest recommendations. Holter ECG - 24 hour Holter ECG will be recorded. Extended Holter ECG analysis will be performed. Detailed echocardiography Detailed CMR examination Body composition analysis - With a sophisticated bio-electrical impedance analysis, comprehensive whole body composition and hydration analysis will be performed. Cardiopulmonary exercise testing - Sport specific protocols will be used on both treadmill and bike ergometers.

Official Title
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Semmelweis Sport - Complex Cardiovascular Screening of Elite, Recreational, Young and Master Athletes

Conditions
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Athletes Heart

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age no known cardiovascular disease history of sport activity (athletes) no history of competitive sport (controls) Exclusion Criteria: History of known relevant cardiac disease (including cardiomyopathies) Contraindication to MRI or cardiopulmonary exercise testing

Ages Eligible for Study
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Minimum Age: 12 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| athletes<br>Healthy highly trained elite athletes, recreational athletes, young and master athletes free of known structural myocardial disease | |
| controls<br>Healthy volunteers without a history of competitive physical exercise | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The primary analysis will be an investigation regarding the athletic adaptation using CMR |  | Baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The primary analysis will be an investigation regarding the athletic adaptation using cardiopulmonary exercise testing |  | Baseline | 
| The primary analysis will be an investigation regarding the athletic adaptation using resting ECG |  | Baseline | 
| The primary analysis will be an investigation regarding the athletic adaptation using 24-Hour Holter ECG |  | Baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Hypertrophy, Left Ventricular, Ventricular Remodeling