Estimating Quality of Life in People With Asthma

Study Overview
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Brief Summary
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The aim of this project is to estimate the quality of life for people with asthma and specifically the loss in quality of life associated with an asthma-related crisis event (accident and emergency (A&E) attendance or admission).

Detailed Description
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Asthma is a serious respiratory condition which causes shortness of breath, chest tightness and wheezing. Quality of life can have an impact on asthmatics due to such symptoms. Previous studies capture quality of life at specific time points (e.g. baseline, 1 month, 3 months), and the assumption of a steady improvement is made. However, these assumptions and time points could miss an asthma event in between. Therefore, the investigators aim to provide a more accurate estimation of the loss in quality of life by following participants over an 8 week period from when the participants have attended A&E or been admitted to hospital following an asthma attack. This will be done by using different quality of life methods, and analysed by calculating the difference between the quality of life scores from A&E attendance / hospital admission and follow-ups.

Official Title
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Estimating the Loss in Quality of Life Associated With an Asthma Related Crisis Event (ESQUARE)

Conditions
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Asthma

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Male or Female 18 years old and over Has asthma alone, or asthma with Chronic Obstructive Pulmonary Disease (COPD) or asthma with a respiratory infection Speaks English Not in need of help from carer / guardian to complete questionnaires Not hypoxemic Not participated in the study before Able to give informed consent Exclusion Criteria: Younger than 18 years old Does not speak English Has participated in the study before Remains hypoxemic despite oxygen therapy Impaired capacity to consent

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Asthma<br>All participants will have an asthma-related crisis event due to an asthma exacerbation that resulted in A&E attendance and/or hospital admission. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| EuroQol 5 Dimensions 5 Level (EQ-5D-5L) | A generic quality of life questionnaire | Once a week from baseline until week 8 | 
| Asthma Quality of Life Questionnaire (AQLQ) | A disease-specific quality of life questionnaire | Once a month from baseline to week 8 | 
| Peak flow and asthma symptom diary | Assessment of peak expiratory flow and asthma symptoms | Every day from baseline to week 8 | 
| Time Trade-Off | Assessment of quality of life. Completed at Norfolk and Norwich University Hospital only. | Once a month from baseline to week 8 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Productivity Questionnaire | Assessment of time lost from work, study or activities from having an asthma exacerbation | Week 4 |