Reward Systems and Food Avoidance in Eating Disorders

Study Overview
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Brief Summary
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The researchers plan to explore brain networks involved in emotion processing and learning using a brain scan and test meals. One core feature of Anorexia Nervosa (AN) is eating a small number of high-calorie or high-fat foods. By studying why individuals with AN are disgusted by food or other eating situations, the researchers will be able to understand more about the neurobiological pathways that lead to restricting food intake and food avoidance. This study also aims to find whether one of two short-term interventions (Interoceptive Exposure (IE); Family-Based Therapy (FBT)) affects connections in the brain and if the treatments affect food avoidance. IE is an intervention that helps reduce anxiety about eating. FBT is an intervention that motivates patients to eat through working with family to increase the value of eating and decrease the value of avoiding foods.

Detailed Description
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Anorexia nervosa (AN), a characteristically relentless pursuit of thinness with an intense fear of weight gain despite significantly low body weight, is a serious psychiatric disorder with high rates of morbidity and mortality. Low weight eating disorders (LW-ED), the broader category of eating pathology that includes AN and similar variants, are characterized by a chronic course, poor response to treatment, and food avoidance. Emerging neuroimaging evidence suggests that deficits in insula-amygdala-ventral striatum (IAVS) neurocircuitry contribute to individual variability in aversive and reward learning, and that these brain regions demonstrate abnormal responses to food/eating stimuli. The researchers' pilot data suggest that patients with LW-ED experience difficulty extinguishing food-cue associations in a reversal learning paradigm compared to healthy controls, a difficulty that is related to psychophysiological measures of aversive disgust (not fear). The researchers have also successfully piloted an interoceptive exposure intervention for this population that targets visceral sensitivity and seeks to increase 'top-down' regulation of the IAVS neurocircuit. The proposed project will (a) use novel fMRI-EMG to test the relationship between effective connectivity within amygdala-insula-ventral striatum network and its relationship to psychophysiological and behavioral measures of acute threat and reward learning in 60 adolescents with LWEDs and 30 healthy controls, (b) test the sensitivity of this network to an experimental interoceptive exposure paradigm relative to patients receiving family based therapy for weight restoration using dynamic causal modeling of fMRI-EMG data pre-post experimental conditions, (c) validate this model against objective measures of laboratory and real world eating behavior. The results of this study will help better understand the core neurocircuitry that underlies both threat processing and reward/aversive learning and how this circuit relates to objective behavior. Further, the researchers will determine the modifiability of this neurocircuitry via two distinct behavioral interventions chosen to target different aspects of affective processing and reward learning. These data will be used to inform future clinical interventions targeting aversive/reward learning within this population and dysregulation in insula-amygdala-ventral striatum subcircuits.

Official Title
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Reward Systems and Food Avoidance in Adolescents With Low Weight Eating Disorders

Conditions
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Low Weight Eating Disorders, Anorexia Nervosa

Intervention / Treatment
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* Behavioral: Interoceptive Exposure (IE)
* Behavioral: Family Based Therapy-Weight Gain Control (FBT-WG)
* Dietary Supplement: meal replacement shake


Participation Criteria
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Eligibility Criteria
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Low Weight ED Patients Inclusion criteria: Females, Adolescents ages 12-18, Speak English, Seeking treatment Refusal to maintain greater than minimally low body weight based on BMI for age percentiles and growth trajectories, Clinically significant restriction of food intake on the dietary restraint subscale of the EDE or evidence of persistent food avoidance as reported by patient or guardians. Given medical clearance from pediatrician or equivalent. Exclusion criteria: Current psychotropic medication that would have an effect on performance on behavioral tasks (i.e., anti-anxiety medication), Comorbid psychotic or bipolar disorder, Active suicidal ideation, Major medical illness known to influence eating or weight, Current substance dependence, Previous exposure therapy for LW-ED. Physical limitation that would prevent participation (e.g., allergic to chocolate), For patients with current or a history of sexual or physical abuse by parents, siblings, or guardians, perpetrators of the abuse will be excluded from treatment; if physical or sexual abuse by a family member occurs during the course of treatment, perpetrators will be excluded from ongoing treatment Healthy Comparison Adolescents Inclusion criteria: Females, Adolescents ages 12-18, Speak English. Exclusion criteria: Current psychotropic medication that would have an effect on performance on behavioral tasks (i.e., stimulant medication), Current or lifetime history of any psychiatric disorder, including eating disorders by K-SADS, Current or lifetime history of learning disorder or developmental disability Active suicidal ideation, Major medical illness, Other physical limitation that would prevent participation (e.g., allergic to chocolate).

Ages Eligible for Study
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Minimum Age: 12 Years
Maximum Age: 18 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Interoceptive Exposure (IE)<br>IE is an exposure-based intervention that involves consuming a food in session and tolerating uncomfortable feelings around eating. | Behavioral: Interoceptive Exposure (IE)<br>* Participants are provided with a meal replacement shake of 'unknown' Kcal or macronutrient content and are asked to mindfully observe the sensations (aversive taste, texture, bloating, icky feeling, etc.) and associated emotional states (i.e., disgust) with the empathetic support of parents/therapist in session, without expectation of habituation. Sessions occur on a weekly basis with session one lasting 2 hrs. The remaining 5 sessions last one hour, and participants eat a meal replacement shake over 30-minutes, identical to the first session. All sessions include debriefing and development of IE homework that includes daily practice of IE.<br>Dietary Supplement: meal replacement shake<br> <br> |
| Active Comparator: Family Based Therapy-Weight Gain Control (FBT-WG)<br>Family-based therapy uses parent(s) to help modify disordered eating and develop contingencies to motivate eating. | Behavioral: Family Based Therapy-Weight Gain Control (FBT-WG)<br>* Participants and families randomized to FBT-WG will receive 6-weeks of FBT treatment for AN. Sessions occur weekly, with the first session lasting two hours and the remaining 5 sessions one hour. FBT is atheoretical in terms of the etiology, but uses parent-enforced contingencies to increase value of eating and decrease the value of food avoidance.<br>|
| No Intervention: Healthy Controls (HC)<br>HC participants will only participate in the pre and post-intervention visits and not in the intervention sessions. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| fMRI-EMG | Change in the emotional responses from facial muscle movements to food pictures and non-food pictures as measured with the fMRI-EMG. | Baseline and 6 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| KCal Intake | Change in KCal Intake at 6 weeks as compared to baseline. Consumption of a standardized strawberry yogurt shake test meal will be measured in kcal. Participants will be presented with an 83 fluid ounce (2454.60-mL) covered opaque container containing approximately 1500 grams (1.04 kcal per gram, or approximately 1560 kcal) of strawberry yogurt shake. Patients will be informed that the meal consists of a strawberry yogurt shake, but will not be told the amount provided in the container. The instructions will direct participants to consume as much of the shake as they would like and that the meal will serve as their lunch (or dinner) for the day and to avoid touching or manipulating the container in any way. | Baseline and 6 weeks | 
| Eating Disorder Examination (EDE) | Change in EDE at 6 weeks as compared to baseline. Clinical interview to assess for eating disorder symptomology. | Baseline and 6 weeks | 
| Clinical Impairment Assessment | Change in assessment at 6 weeks as compared to baseline. The Clinical Impairment Assessment (CIA) is a 16-item self-report measure of the severity of psychosocial impairment due to eating disorder features on the past 28 days. Each item are scored 0, 1, 2, 3 with a higher rating indicating a higher level of impairment, with total score ranging from 0 to 48 with a higher score being indicative of a higher level of psychosocial impairment secondary to eating disorder features. | Baseline and 6 weeks | 
| Anxiety Sensitivity Index-III | Change in index at 6 weeks as compared to baseline. Self-reported anxiety symptomology | Baseline and 6 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Eating Disorders, Food Avoidance, Reward Learning, Reward System, Family-based treatment, interoceptive exposure, insula-amygdala-ventral striatum subcircuits