Conjugated Linoleic Acid in Obese Women

Study Overview
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Brief Summary
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In this trial, the investigators analyzed the effects of eight weeks of CLA supplementation associated with aerobic exercise on body fat and lipid profile in obese women.

Detailed Description
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The aim of this investigation was to analyze the effects of eight weeks of CLA supplementation associated with aerobic exercise on body fat and lipid profile in obese women. The investigators performed a randomized, double-blinded and placebo-controlled trial with 28 obese women who received 3.2 g/d of CLA or 4 g/d of olive oil (placebo group) while performing an 8-week protocol of aerobic exercise. Dietary intake (food record), body fat (DXA) and biochemical analysis (blood sample) were assessed before and after the intervention period.

Official Title
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Effect of Conjugated Linoleic Acid Associated With Aerobic Exercise on Body Fat and Lipid Profile in Obese Women: A Randomized, Double-blinded and Placebo-controlled Trial

Conditions
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Lipid Metabolism Disorders, Obesity

Intervention / Treatment
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* Dietary Supplement: CLA
* Behavioral: Placebo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Had no signs or symptoms of disease No orthopedic injuries Must be inactive or moderately active (defined as performing any type of physical exercise less than twice a week) Must be non-smokers Must be free from the use of ergogenic aids Had no metabolic disorders or chronic degenerative diseases Not use drug therapy for body mass loss. Exclusion Criteria: Had frequency to training sessions below 85% of the total sessions

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Aerobic exercise associated with CLA<br>CLA group received supplementation at a dose of 3.2 g/day (mixture of isomers of CLA isomers predominantly c9, t11 - 50% and c12, t10 - 80%). | Dietary Supplement: CLA<br>* CLA group received supplementation at a dose of 3.2 g/day (mixture of isomers of CLA isomers predominantly c9, t11 - 50% and c12, t10 - 80%). Aerobic exercise associated with CLA<br>|
| Placebo Comparator: Aerobic exercise<br>Placebo group received 4 g/day of olive oil. | Behavioral: Placebo<br>* Placebo group received 4 g/day of olive oil. Aerobic exercise<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Body fat | Dual-energy X-ray absorptiometry | 8 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Total cholesterol | Blood analysis | 8 weeks | 
| Triglycerides | Blood analysis | 8 weeks | 
| High-density lipoprotein | Blood analysis | 8 weeks | 
| Low-density lipoprotein | Estimated by Friedewald formula | 8 weeks | 
| Trunk fat | Dual-energy X-ray absorptiometry | 8 weeks | 
| Arm fat | Dual-energy X-ray absorptiometry | 8 weeks | 
| Leg fat | Dual-energy X-ray absorptiometry | 8 weeks |