Diffusion Weighted Magnetic Resonance Imaging and the Optic Nerve Neuropathy.

Study Overview
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Brief Summary
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The aim of the project is to create a new, non-invasive and safe protocol for the early diagnosis of various types of optic neuropathies with the use of diffusion magnetic resonance imaging

Detailed Description
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In this study, it is planned to find twenty volunteers for each of the neuropathies and twenty healthy volunteers. Each volunteer will undergo clinical tests such as visual acuity, color vision, intraocular pressure measurement, assessment of the anterior chamber and fundus using a slit lamp and Volk lens, macular optical coherence tomography examination and examination of the optic nerve disc (OCT), neurological field vision and visual evoked potential (VEP) testing. Each of the volunteers will undergo magnetic resonance imaging. During active scanning, patients will be asked for not blinking or moving their heads by staring at the red dot on the outside of the camera reflected in the coil mirror. The obtained diffusion tensor data will be used for further analysis.

Official Title
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Diffusion Weighted Magnetic Resonance Imaging and the Optic Nerve Neuropathy.

Conditions
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Ischemic Optic Neuropathy, Optic Neuritis, Compressive Optic Neuropathy, Traumatic Optic Neuropathy, Toxic Optic Neuropathy, Hereditary Optic Neuropathies

Intervention / Treatment
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* Device: Neuroimaging
* Diagnostic Test: VEP - visual evoked potential
* Diagnostic Test: Ophthalmology examination.


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Optic neuropathy. Exclusion Criteria: common contraindications to MRI (presence of pacemaker, non-MRI-safety or claustrophobia)

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Crossover Assignment
Interventional Model Description: Two groups: volunteers with neuropathies and healthy volunteers
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Various types of optic neuropathies<br>Patients with various types of optic neuropathy. | Device: Neuroimaging<br>* Magnetic resonance diffusion tensor imaging of the brain<br>Diagnostic Test: VEP - visual evoked potential<br>* Electrophysiology of the visual pathway.<br>Diagnostic Test: Ophthalmology examination.<br>* Full ophthalmological examination (visual acuity, color vision, measurement of intraocular pressure, evaluation of the anterior chamber and the fundus of the eye using a slit lamp and the Volk lens, optical coherence tomography examination of the macula and optic nerve disc (OCT), neurological field vision)<br>|
| Other: Healthy volunteers<br>Healthy volunteers | Device: Neuroimaging<br>* Magnetic resonance diffusion tensor imaging of the brain<br>Diagnostic Test: VEP - visual evoked potential<br>* Electrophysiology of the visual pathway.<br>Diagnostic Test: Ophthalmology examination.<br>* Full ophthalmological examination (visual acuity, color vision, measurement of intraocular pressure, evaluation of the anterior chamber and the fundus of the eye using a slit lamp and the Volk lens, optical coherence tomography examination of the macula and optic nerve disc (OCT), neurological field vision)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| sigma parameter | sigma parameter in our algorithm provides a quantitative measure of nerve atrophy | one month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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optic neuropathies, visual evoked potential