Study by Magnetic Resonance Imaging in the Progressive Forms of Multiple Sclerosis

Study Overview
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Brief Summary
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The goal of this study is to show pattern differences of vasoreactivity and connectivity between Progressive Multiple Sclerosis and Relapsing Remitting Multiple Sclerosis, by the use of methods of advanced brain MRIs and the Diffusion Tensor Imaging , and correlate these differences with Clinical disability and cognitive disorder results.

Detailed Description
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The goal of this study is to show pattern differences of vasoreactivity and connectivity between Progressive Multiple Sclerosis and Relapsing Remitting Multiple Sclerosis, by the use of methods of advanced brain MRIs, and correlate these differences with Clinical disability and cognitive disorder results. The modification of the Diffusion Tensor Imaging are well known in these two groups, as well as their link with the occurrence of movement and cognitive disorder. The study of the vasoreactivity during MRI aims to confront our results to the available data sources.

Official Title
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Study by Magnetic Resonance Imaging of the Modifications of the Vasoreactivity and Cerebral Connectivity in the Progressive Forms of Multiple Sclerosis

Conditions
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Progressive Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting

Intervention / Treatment
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* Other: Neuropsychological assessment
* Other: Neurologic consultation
* Other: MRIs (with vasoreactivity testing)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria : For Both patients and healthy volunteers : Age limits ≥ 30 et ≤ 50 years Subject able to understand the nature, the aim and the methodology of the study. Collection of the informed consent Affiliation or recipient with the mode of social security. For the patients : Suffering from progressive multiple sclerosis (primary progressive forms or secondary progressive forms) OR Suffering from relapsing-remitting multiple sclerosis Exclusion Criteria : For Both patients and healthy volunteers : Systemic pathology with neurological manifestations Antecedent of psychiatric disorders including psychosis (Except anxious depressive disorder) Subject presenting contraindications in MRI (Ferromagnetic foreign bodies, pace-maker) Claustrophobia Women pregnant or Breast-feeding Person with majority age protected by the law (supervision, trusteeship or under safeguard of justice). Subject unable to understand the nature and the aim of the study and/or communication difficulties with investigator Antecedent of serious cranial trauma (according to classification) of ischaemic stroke ou intracranial hematoma. For the patients : Antecedent of serious cranial trauma (according to classification), anterior or evolutive neurologic disease other than multiple sclerosis Recent relapse of multiple sclerosis For the healthy volunteers : Antecedent of serious cranial trauma (according to classification), anterior or evolutive neurologic disease Antecedent of neurological disease In period of exclusion relative to another protocol or which the annual amount of the allowances maximum of 4500 € was reached.

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Progressive Multiple Sclerosis<br>22 patients with Progressive Multiple Sclerosis will be included and they get an Neuropsychological assessment, a Neurologic consultation and MRIs (with vasoreactivity testing) | Other: Neuropsychological assessment<br>* A neuropsychological assessment is done<br>Other: Neurologic consultation<br>* A neurologic consultation is done<br>Other: MRIs (with vasoreactivity testing)<br>* MRIs (with vasoreactivity testing) is done<br>|
| Experimental: Multiple Sclerosis, Relapsing-Remitting<br>22 patients with Multiple Sclerosis, Relapsing-Remitting will be included and they get an Neuropsychological assessment, a Neurologic consultation and MRIs (with vasoreactivity testing) | Other: Neuropsychological assessment<br>* A neuropsychological assessment is done<br>Other: Neurologic consultation<br>* A neurologic consultation is done<br>Other: MRIs (with vasoreactivity testing)<br>* MRIs (with vasoreactivity testing) is done<br>|
| Experimental: Healthy volunteers (22 patients)<br>22 healthy volunteers will be included and they get an Neuropsychological assessment and MRIs (with vasoreactivity testing) | Other: Neuropsychological assessment<br>* A neuropsychological assessment is done<br>Other: MRIs (with vasoreactivity testing)<br>* MRIs (with vasoreactivity testing) is done<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cerebral vasoreactivity measured by diffusion imaging MRI (quantitative variable) :parameter which allow us to estimate the organization of the white matter tracts |  | 2 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of fonctional connective cards at Resting state | somatomotor network and default mode network | 2 months | 
| Cognitive disorders | Neuropsychological test results (quantitative and quantitative variable) | 2 months |