Phase II Study of Celecoxib and Concurrent Radiotherapy in Stage II-III NSCLC

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to investigate the effect of the adminstration of celecoxib, a cox2-inhibitor in patients with stage II-III non small cell lung cancer receiving radical radiotherapy. The hypothesis is that celecoxib will increase the remission rate of radiotherapy.

Detailed Description
-----------------
Treatment of non-small cell lung cancer (NSCLC) is difficult, even with the best classical radiation and chemotherapy schedule results remain disappointing. However, there is evidence that increasing the local control rate by delivering radiotherapy either in a short period of time or concomitantly with chemotherapy improves survival. Drawback of a higher radiation dose or addition of chemotherapy is a higher incidence of toxicity. So radiation dose escalation could lead to further improvements of prognosis, but the radiation dose is however limited by radiation-induced lung and esophageal damage. For NSCLC, non-toxic agents who both increase the effectiveness of radiotherapy and decrease radiation induced lung and esophageal damage are needed. The cox-2-inhibitors seem to be suitable for this purpose. In experimental mice tumor models, it was already shown that COX-2-inhibitors both inhibit tumor growth and enhance the radio-response of the tumor. Moreover, anti-inflammatory agents, such asCOX-2-inhibitors, also lowered the incidence of radiation pneumonitis and esophagitis. In this study the simultaneous favourable effects of COX-2 inhibitors on tumor response and radiation damage in human cancer patients will be investigated. Patients will be randomised to receive Celecoxib or placebo. All patients will receive the same radiotherapy treatment. Primary outcome measure is tumor response, assessed by a CT-scan of the thorax, three months after radiotherapy. The tumor response rate of the experimental group will be compared to the tumor response rate of the control group.

Official Title
-----------------
A Multicentre Randomised Double Blind Placebo-Controlled Phase II Study of Celecoxib and Concurrent Radiotherapy in Stage II-III NSCLC. An Evaluation of Both Tumor Radiosensitization and Normal Tissue Protection

Conditions
-----------------
Non Small Cell Lung Carcinoma

Intervention / Treatment
-----------------
* Drug: Celecoxib


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: histologically proven non-small cell lung cancer UICC stage II-III WHO performance status 0-2 less than 10% weight loss the last 6 month in case of previous chemotherapy, radiotherapy may start after a minimum of 21 days after the last chemotherapy course reasonable lung function: FEV1>30% of the predicted value no recent(<3month) severe cardiac disease no active peptic ulcer disease normal serum bilirubin normal serum creatinin life expectancy more than 6 month measurable cancer willing and able to comply with the study prescriptions able to give written informed consent before patient registration/randomisation no previous radiotherapy to the chest Exclusion Criteria: not not small cell histology, e.g. mesothelioma, lymphoma mixed pathology, e.g. non small cell plus small cell cancer malignant pleural or pericardial effusion concurrent chemotherapy with radiation recent (<3month) myocardial infarction uncontrolled infectious disease distant metastases (stage IV) patients with active peptic ulceration or gastrointestinal bleeding in the last year patients with a past history of adverse reaction to NSAIDs renal disease chronic use of NSAIDs, COX-2 inhibitors or Aspirin in dosis >120mg/day.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Celecoxib|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| tumor response rate |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| local progression free survival 9 months after radiotherapy |  |  | 
| radiopneumonitis |  |  | 
| lung fibrosis,6 month post radiotherapy |  |  | 
| acute esophagitis |  |  | 
| quality of life |  |  | 
| survival after 1 year |  |  | 
| survival after 2 years |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
NSCLC, cox-2-inhibitor, radiosensitizer, radiotherapy