Efficacy Comparison Between Different Management Strategies for Consistent OAB in Patients With SVMs After Surgery

Study Overview
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Brief Summary
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The investigators' goal is to compare the efficacy of three different management strategies (sacral neuromodulation, botulinum toxin, M receptor antagonist) in treating consistent OAB in patients with SVMs after surgery.

Detailed Description
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Spinal Vascular malformations (SVMs) are complex neurosurgical lesions and account for 3%-4% of all intradural spinal cord mass lesions, which can influence the function of bladder. The investigators' goal is to compare the efficacy of three different management strategies (sacral neuromodulation, botulinum toxin, M receptor antagonist) in treating consistent OAB (Overactive Bladder) in patients with SVMs after surgery.

Official Title
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Efficacy Comparison Between Different Management Strategies for Consistent Overactive Bladder (OAB) in Patients With Spinal Vascular Malformations After Surgery

Conditions
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Spinal Vascular Disorder Nos, Overactive Bladder

Intervention / Treatment
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* Procedure: surgery
* Procedure: sacral neuromodulation
* Procedure: botulinum toxin A injection
* Drug: M receptor antagonist


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: •Patient diagnosed with spinal vascular diseases including Intradural arteriovenous malformation,Intradural arteriovenous fistula,Dural arteriovenous fistula,Extradural arteriovenous malformation,Paravertebral arteriovenous malformation,Paravertebral arteriovenous fistula,cobbs' syndrome,and other spinal arteriovenous metameric syndromes involve the spinal cord. patient not received surgical or interventional treatment before patient with normal cardiac, renal and hepatic function patient capable of understanding the content of the patient information / Informed Consent Form patient willing and able to participate in the registry patients have consistent OAB after surgery Exclusion Criteria: •patient received surgical treatment or interventional treatment before patient is pregnant patient allergic to iodine patient unable to complete follow-up patient with cerebral lesions patient with other spinal lesions patient with cardiac, renal or hepatic dysfunction

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: patients with SVMs undergoing SNM<br>patients with SVMs are of consistent OAB (Overactive Bladder) after surgery and undergo sacral neuromodulation (SNM) | Procedure: surgery<br>* patients with SVMs receive surgery<br>Procedure: sacral neuromodulation<br>* sacral neuromodulation (SNM) with InterStimTM<br>|
| Experimental: patients with SVMs receiving BTXA<br>patients with SVMs are of consistent OAB after surgery and accept botulinum toxin A (BTXA) injection | Procedure: surgery<br>* patients with SVMs receive surgery<br>Procedure: botulinum toxin A injection<br>* BOTOX<br>|
| Experimental: patients with SVMs receiving drug<br>patients with SVMs are of consistent OAB (Overactive Bladder) after surgery and accept M receptor antagonist | Procedure: surgery<br>* patients with SVMs receive surgery<br>Drug: M receptor antagonist<br>* Tolterodine<br>* Other names: Tolterodine;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| bladder function | bladder function change in urodynamics | 3 months and 12 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Spinal Vascular Disorder, Overactive Bladder