Role of High Flow Nasal Oxygen as a Strategy for Weaning From Invasive Mechan

Study Overview
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Brief Summary
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evaluate the Efficacy of high flow nasal oxygen as a weaning strategy in mechanically ventilated patients with respiratory failure.

Detailed Description
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Acute respiratory failure is a main cause of IMV and admission to intensive care unit (ICU){1}. The day of extubation is a critical time during an intensive care unit (ICU) stay because in case of postextubation failure {2},which reach to 25 - 40% from extubated patient associated with VAP and barotrauma, mortality rate and hospital stay will increase , we use Adjuvant oxygen therapy to prevent these undesirable event like COT ,NIV and High-flow nasal cannula (HFNC) which can be used as an initial weaning strategy from IMVdue to its physiologic benefits [3-4]. HFNC devices supply between 30 and 60 L/min of a controlled mixture of actively warmed (32-37 °C) and humidified (up to 100% relative humidity) oxygen and air through modified nasal prongs. producing {5-6-7}: moderate positive end-expiratory pressure (PEEP) . HFNC might help prevent extubation failure through different Mechanisms: First, the controlled oxygen concentration may reduce transient hypoxemic episodes . Second, the high flow washes the nasopharyngeal dead space, thus reducing CO2 re-breathing; this effect reduces respiratory rate and minute ventilation . Third, the small amount of PEEP may reduce lung collapse . c)enabling better gas exchange and reduced work of breathing. d)in patients with chronic obstructive pulmonary disease (COPD), this level of PEEP may counterbalance auto PEEP, further reducing the work of breathing. e) humidification may improve mucus drainage and reduce mucus retention, alleviating the associated atelectasis.

Official Title
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Role of High Flow Nasal Oxygen as a Strategy for Weaning From Invasive Mechan

Conditions
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Respiratory Failure With Hypoxia

Intervention / Treatment
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* Device: High Flow Nasal Cannula


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 1- All adult patients who were admitted to our ICU requiring endotracheal intubation (ETI), were eligible for the study. Exclusion Criteria: Non-intubated patients or those with tracheostomy were excluded from the study. those having neurological alteration unrelated to hypercapnoeic encephalopathy, cranio-facial deformity, upper airway obstruction, cardiogenic pulmonary edema, cardiogenic shock, acute myocardial infarction, pneumothorax, pulmonary neoplasm, pulmonary thromboembolism, gastrointestinal bleeding, and post-operative respiratory failure. Patients less than 18 y.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 100 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: High Flow Nasal Cannula|use of high flow nasal cannula as a weaning mode from invasive mechanical ventilation to deliver oxygen|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Is patient outcome in terms of survival or death at discharge. | evaluate the Efficacy of high flow nasal oxygen as a weaning strategy in mechanically ventilated patients with respiratory failure as regarding Hospitalization ,complications, oxygenation , reintubation rate, mortality rate. | through study completion average 7 days. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Duration of ICU stay through study completion average 7 days ,Adverse events. | evaluate efficacy of high flow nasal cannula on duration of hospital stay, complications rate. | through study completion average 7 days. |