Measurement of Viral Load Reduction in the Oral Cavity After a Regimental Use of OC Toothpaste Products

Study Overview
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Brief Summary
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SARS COVID 2 has caused a pandemic of proportions unparalleled in the past 100 years. The virus has an uncanny ability for transmission and as such has been difficult to control. The spread of the virus has affected everything from education, business, politics and survival. While the investigators have learned a great deal in the last 9 months they still face an uncertain day to day existence. Health care workers are particularly vulnerable to transmission of this virus because of their close contact with patients. Moreover, dentists are particularly vulnerable because the virus is spread via aerosols which are generated quite easily in the dental office putting dentists and their associates at risk. The oral cavity appears to be a likely domain for viral carriage particularly since both taste and smell are hallmark effects of the virus. With these issues at hand it will be of great advantage to have a simple routine oral hygiene method in the effort to reduce the oral viral load. There is some reason to expect that oral hygiene procedures with known anti-microbial effects could have some use in our efforts to reduce or control the oral viral load. With this issue in mind investigators feel that stannous fluoride could modify the virus in such a manner as to effectively reduce the oral viral load.

Detailed Description
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Study will measure reduction of SARS-CoV-2 levels in the oral cavity after brushing for up to an hour. Subject sampling will occur at baseline, 15 min, 30 min, and 60 min

Official Title
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Measurement of Viral Load Reduction in the Oral Cavity After a Regimental Use of OC Toothpaste Products

Conditions
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Covid19

Intervention / Treatment
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* Drug: Colgate Total Clean Mint
* Drug: Tom's Botanically Bright Peppermint


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Enrolled subjects between the ages of 18-64 and have tested positive for Covid19. Exclusion Criteria: -

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 64 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Colgate Total Clean Mint<br>Brush with toothpaste for a minimum of 2 minutes | Drug: Colgate Total Clean Mint<br>* 2 minutes of whole mouth toothbrushing<br>* Other names: Toothpaste;|
| Active Comparator: Tom's Botanically Bright Peppermint<br>Brush with toothpaste for a minimum of 2 minutes | Drug: Tom's Botanically Bright Peppermint<br>* 2 minutes of whole mouth toothbrushing<br>* Other names: Toothpaste;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Primary outcome based on reductions of viral titers in the oral cavity as determined by qRT-PCR | Primary outcome based on reductions of viral titers in the oral cavity as determined by qRT-PCR | Baseline | 
| Primary outcome based on reductions of viral titers in the oral cavity as determined by qRT-PCR | Primary outcome based on reductions of viral titers in the oral cavity as determined by qRT-PCR | 30 minutes after brushing | 
| Primary outcome based on reductions of viral titers in the oral cavity as determined by qRT-PCR | Primary outcome based on reductions of viral titers in the oral cavity as determined by qRT-PCR | 60 minutes after brushing |