Memory and Emotion in Acute and Chronic Phases of Cerebrovascular Accident

Study Overview
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Brief Summary
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The purpose is to determine the relationship between anxiety and cognitive performances in patients with acute and chronic phases of cerebrovascular accident (CVA). Data from neuropsychological assessment concerning cognitive processes (working and episodic memory) sensitive to different dimensions of anxiety will be analyzed. The secondary purpose is to evaluate how some neurological (hemispherical lateralization of lesions), psychological (depression) and demographic (quality of life) variables can increase the effects of different dimensions of anxiety on cognitive processes, during the acute and/or chronic phase of CVA.

Detailed Description
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Data will be collected during usual neuropsychological evaluation and cerebral imagery examination (NIHSS, Rankin scale) of patients in acute (0-1 month) and chronic (6 months) phases of CVA.

Official Title
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Memory and Emotion in Acute and Chronic Phases of Cerebrovascular Accident

Conditions
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Cerebrovascular Accident

Intervention / Treatment
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* Other: Standard neuropsychological assessment
* Other: Brain MRI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Acute phase of carotid, vertebrobasilar or lacunar cerebrovascular accident with ischemic or hemorrhagic origin Right-handed Possible cooperation: understanding of French instructions Normal or corrected vision Normal or corrected hearing Mini-mental state examination score higher than pathologic threshold according to age and sociocultural level of patient Possible follow up of patient Exclusion Criteria: Hearing problems Vision problems Right hemiplegia or acute monoparesis of right upper limb Hemispatial neglect Apraxia Psychiatric or neurological history possibly interfering with neuropsychological evaluation Important defect of working memory or executive functions

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with cerebrovascular accident<br> | Other: Standard neuropsychological assessment<br> <br> Other: Brain MRI<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| State of anxiety evaluated with STAI-YA scale |  | up to 1 month (from CVA) | 
| State of anxiety evaluated with STAI-YA scale |  | 6 months (from CVA) | 
| Anxiety proneness evaluated with STAI-YB scale |  | up to 1 month (from CVA) | 
| Anxiety proneness evaluated with STAI-YB scale |  | 6 months (from CVA) | 
| Apprehension anxiety evaluated with Penn State Worry Questionnaire |  | up to 1 month (from CVA) | 
| Apprehension anxiety evaluated with Penn State Worry Questionnaire |  | 6 months (from CVA) | 
| Evaluation of working memory updating with N-back verbal and visuospatial task |  | up to 1 month (from CVA) | 
| Evaluation of working memory updating with N-back verbal and visuospatial task |  | 6 months (from CVA) | 
| Evaluation of working memory inhibition with Stimulus-response compatibility task |  | up to 1 month (from CVA) | 
| Evaluation of working memory inhibition with Stimulus-response compatibility task |  | 6 months (from CVA) | 
| Evaluation of working memory flexibility with Switching task |  | up to 1 month (from CVA) | 
| Evaluation of working memory flexibility with Switching task |  | 6 months (from CVA) | 
| Evaluation of verbal working memory with Wechsler memory scale |  | up to 1 month (from CVA) | 
| Evaluation of verbal working memory with Wechsler memory scale |  | 6 months (from CVA) | 
| Evaluation of visuospatial working memory with Wechsler memory scale |  | up to 1 month (from CVA) | 
| Evaluation of visuospatial working memory with Wechsler memory scale |  | 6 months (from CVA) | 
| Evaluation of visual episodic memory with Rey and Taylor figure test |  | 6 months (from CVA) | 
| Evaluation of verbal episodic memory with RL/RI 16 item test |  | 6 months (from CVA) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hemispheric lateralization of lesions detected with MRI |  | up to 1 month from CVA | 
| Depression state evaluated with Back depression inventory |  | up to 1 month (from CVA) | 
| Depression state evaluated with Back depression inventory |  | 6 months (from CVA) | 
| Quality of life evaluated with SF-36 test |  | after 6 months from CVA |