Revealing Microbiome Association With (Plant-based) Diet in Freshman

Study Overview
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Brief Summary
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Aim of the study is to evaluate the impact of a vegan vs. vegetarian dietary pattern compared to an omnivore diet on body weight, saliva and stool microbiome profiles, as well as saliva, urine and plasma metabolome profile changes in freshmen after the first year at university/college.

Official Title
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Revealing Microbiome Association With (Plant-based) Diet in Freshman

Conditions
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Healthy

Intervention / Treatment
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* Other: cross-sectional observation
* Other: cross-sectional follow-up observation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: freshman following a vegan / vegetarian / omnivore dietary pattern for at least 3 months own a smartphone (including internet access and camera) Exclusion Criteria: regular use of medication (excluding oral contraceptiva) use of antibiotics in the last 6 weeks chronic disease, especially gut diseases following a vegan / vegetarian / omnivore dietary pattern for less then 3 months no clear assignment of vegan / vegetarian / omnivore dietary pattern electrical implants

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 25 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| vegan<br>subjects having a vegan nutrition pattern for at least the last 3 months | Other: cross-sectional observation<br>* observation of dietary patterns, body weight status, microbiome and metabolome profiles at the start of the first semester<br>Other: cross-sectional follow-up observation<br>* follow-up observation of dietary patterns, body weight status,microbiome and metabolome profiles after one year<br>|
| vegetarian<br>subjects having a vegetarian nutrition pattern for at least the last 3 months | Other: cross-sectional observation<br>* observation of dietary patterns, body weight status, microbiome and metabolome profiles at the start of the first semester<br>Other: cross-sectional follow-up observation<br>* follow-up observation of dietary patterns, body weight status,microbiome and metabolome profiles after one year<br>|
| omnivores<br>subjects having a omnivore nutrition pattern for at least the last 3 months | Other: cross-sectional observation<br>* observation of dietary patterns, body weight status, microbiome and metabolome profiles at the start of the first semester<br>Other: cross-sectional follow-up observation<br>* follow-up observation of dietary patterns, body weight status,microbiome and metabolome profiles after one year<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change in body weight | change in body weight | one year | 
| change in fat mass | change in body composition | one year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| saliva metabolome | changes in saliva metabolome | one year | 
| gut microbiome | changes in gut microbiome | one year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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freshman, vegan, vegetarian, omnivore, microbiome, meal frequency, meal timing, freshman weight gain, metabolome