Effects of the Odour of the Very Preterm Infant on Maternal Psychobiology

Study Overview
=================
Brief Summary
-----------------
At birth, the study of interactions, particularly sensory interactions between a mother and her child, allows us to better understand the process of attachment. The sensory signals within the mother-infant dyad will lead to behavioural and metabolic adaptations in both individuals. Currently, the conditions of reception of a very premature newborn in the neonatal intensive care unit of the CHU of Nice lead to a separation between mother and child, with a reduction in sensory interactions. The immediate and long-term consequences of this sensory rupture are widely documented in the child, but little studied in the mother. The hypothesis at the origin of this work is that olfactory stimulations emanating from the newborn would allow a perceptive continuity between the newborn and his mother. In the pathological situation of the birth of a premature child, these stimulations would lead to neurobiological and behavioural modifications in the mother and would play a role in the attachment process.

Official Title
-----------------
Effects of the Odour of the Very Preterm Infant on Maternal Psychobiology

Conditions
-----------------
Premature Birth

Intervention / Treatment
-----------------
* Other: photography+odour
* Other: photography


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Immediate postpartum mothers of newborns with a term of < 33 weeks (32 weeks + 6 days) primiparous mothers Mothers with vaginal delivery, without oxytocin infusion after delivery Mothers planning to breastfeed, with no maternal contraindication to breastfeeding Exclusion Criteria: Substance abuse: active smoking at the time of delivery, alcohol, drugs Use of medication: antidepressants or psychotropic drugs or centrally acting anti-emetics Active depression or history of depression (under medical care with medical follow-up) in the year preceding the birth, on questioning Chromosomal abnormality or congenital malformation of pre- or post-natal diagnosis in the newborn Language barrier not allowing proper explanation of the protocol and responses to questionnaires

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: VIZOLF<br>visual stimulus (photograph of the child) and olfactory stimulus ad libitum, with a minimum of 6 stimulations per day, to the body odour emitted by the child during the first 5 days of life | Other: photography+odour<br>* Daily from D0 to D5: a square of cotton cloth will be placed against the child's scalp by the childcare worker in charge of the child, then removed and placed in a sealed box containing a photograph of the child, which will then be given to the mother.<br>|
| Experimental: VIZ<br>visual stimulus (photograph of the child) and olfactory stimulus ad libitum, with a minimum of 6 stimulations per day, to a neutral odour during the first 5 days of life | Other: photography<br>* A neutral smelling cloth will be placed with the child's photograph which will then be given to the mother.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in ocytocine levels |  | Day 4 |