Gene-based Personalised Diet and Physical Activity Advice on Adiposity Indices Personalised Diet and Physical Activity Advice on Adiposity Indices in University Students

Study Overview
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Brief Summary
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A longitudinal study to determine the effect of gene-based personalised diet and physical activity advice on adiposity indices in university students.

Detailed Description
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The study uses a randomised controlled design; data for all variables (participant characteristics, height, weight, body mass index (BMI), waist circumference (WC), body fat percentage (BF%), healthy eating motivation, dietary intake and physical activity) will be collected initially from participants at St Mary's University during September and October 2019. Participants will be genotyped, stratified randomisation (based on genotype and BMI) will be used to allocate participants to three different groups (1. Control: no advice, 2. Non genetic personalised advice: dietary and physical activity advice based on reported dietary intake and physical activity 3. Genotype- based personalised advice: dietary and physical activity advice based on genotype, reported dietary intake and physical activity. Following allocation to groups participants in groups 2 and 3 will receive appropriate dietary and physical activity advice via email (appendix a) and all participants will complete the healthy eating motivation questionnaire for a second time. In April/May 2020 follow up variables (smoking status, weight, BMI, WC, BF%, healthy eating motivation, dietary intake and physical activity) will be measured again. These follow up variables will be measured every September and April/May until September 2022. After each follow up participants in groups 2 and 3 will be resent their dietary and physical activity advice and updated information based on their reported dietary intake and physical activity.

Official Title
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A Longitudinal Study to Determine the Effect of Gene-based Personalised Diet and Physical Activity Advice on Adiposity Indices in University Students

Conditions
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Adiposity, Behavior, Health

Intervention / Treatment
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* Genetic: Genotype- based personalised advice
* Behavioral: Non genetic personalised advice


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: • Age 18-25 years Exclusion Criteria: Pregnancy and lactation Chronic disease A history of disordered eating and following a restricted diet.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 25 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Control<br>no advice | |
| Active Comparator: Non genetic personalised advice<br>dietary and physical activity advice based on reported dietary intake and physical activity | Behavioral: Non genetic personalised advice<br>* Following allocation to groups participants will receive appropriate dietary and physical activity advice based on their reported intake, BMI and activity via email<br>|
| Experimental: Genotype- based personalised advice<br>dietary and physical activity advice based on genotype, reported dietary intake and physical activity | Genetic: Genotype- based personalised advice<br>* Following allocation to groups participants will receive appropriate dietary and physical activity advice based on their genotype via email<br>Behavioral: Non genetic personalised advice<br>* Following allocation to groups participants will receive appropriate dietary and physical activity advice based on their reported intake, BMI and activity via email<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Body weight in kg | Weight will be measured to the nearest 0.1 kg | 3 years | 
| Body fat percentage | Body fat percentage will be measured to the nearest 0.1% | 3 years | 
| Body mass index in Kg/m2 | calculated from measured height and weight | 3 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Dietary intake | using a four day food diary collected using a food diary and nutritional analysis app (Libro, 2018) | 3 years | 
| Physical activity | using the Epic Physical Activity Questionnaire (EPAQ2) (Wareham et al., 2002) | 3 years | 
| Participants motivation to eat healthily | measured using the Healthy Eating Motivation Score (Naughton et al., 2015) | 3 years |