Treatment of Atrophic Acne Scars With Platelet-Rich Plasma and Skin Needling

Study Overview
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Brief Summary
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Investigators will collect blood specimens from the participating patients and then blood samples will be centrifuged in order to collect platelet-rich plasma which is going to be injected in the atrophic acne scars. A split-face design is going to used in this randomized controlled trial. In the control side of the face, micro-needling to the skin will occur using a specific tool (Dermapen).

Detailed Description
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Atrophic acne scar is a common problem with a challenging treatment. Platelet-rich plasma (PRP) is an autologous preparation of platelets in concentrated plasma that may be beneficial in the treatment of atrophic acne scars by promoting collagen deposition. Skin needling is a technique that uses a sterile micro needles to puncture the skin and release growth factors. The combination of skin needling and PRP could enhance the efficacy of both modalities.

Official Title
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Treatment of Atrophic Acne Scars With Platelet-Rich Plasma Alone or in Combination With Skin Needling: A Randomized Controlled Trial

Conditions
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Atrophic Acne Scars

Intervention / Treatment
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* Procedure: Platelet-Rich Plasma
* Procedure: Micro-needling


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Atrophic acne scars on both sides of the face Exclusion Criteria: patients with active acne, herpes labialis, or bacterial infection; warts on the face, actinic keratosis, or skin cancer systemic retinoids intake in the previous 6 months, diabetes, pregnancy, history of keloidal scarring; or patients with severe systemic illness or malignancy patients on anticoagulant therapy or aspirin or have a coagulation issue, patients with hemoglobin less than 10g\dl or platelet less than 105 micron\l any previous procedures for acne scar within the last 6 months

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Platelet-Rich Plasma alone<br>The scars will be injected with Platelet-Rich Plasma alone. | Procedure: Platelet-Rich Plasma<br>* This Platelet-Rich Plasma will be taken from each patient and is going to be used in the treatment of atrophic acne scars<br>|
| Active Comparator: Platelet-Rich Plasma with micro-needling<br>The scars will be dealt with using micro-needling as well as injecting Platelet-Rich Plasma | Procedure: Platelet-Rich Plasma<br>* This Platelet-Rich Plasma will be taken from each patient and is going to be used in the treatment of atrophic acne scars<br>Procedure: Micro-needling<br>* Micro-needling will be applied on the acne scars in one side of the face.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Scar Appearance |  | Scar Appearance will be assessed at: T1; one day (wihtin 24 hours) before the application of the intervention(s); and T2: after three months of applying the intervention(s). | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patients' Satisfaction | The assessment will be based on a questionnaire | This is going to be assessed six months following the application of the intervention and the active comparator |