Study of Sensorimotor Compatibility Effects in Bipolar Affective Disorder.

Study Overview
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Brief Summary
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Based in an embodied approach of cognition, several studies have highlighted a direct link between perception of an object or an emotion and the associated motor responses. This study investigated in patients suffering from bipolar affective disorders whether the perception of emotional words involves an automatic sensorimotor simulation of approach and avoidance behaviors, and whether the perception of an object involves an automatic sensorimotor simulation of object prehension (affordance). We hypothesize that, in this pathology, low level (sensorimotor) cognitive processes are preserved whereas high-level (attentional) are altered. 20 patients suffering from bipolar affective disorders and 20 healthy controls will be recruited. The main objective is the emergence of sensorimotor compatibility effects in approach-avoidance task with emotional stimuli (gain between compatible vs incompatible conditions).

Official Title
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Study of Sensorimotor Compatibility Effects in Bipolar Affective Disorder.

Conditions
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Bipolar Affective Disorder

Intervention / Treatment
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* Behavioral: cognitive tasks + IQ + MINI
* Behavioral: cognitive tasks


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: For patients: Affiliated or entitled to a social security Aged between 18 and 55 Patients of both sexes suffering from bipolar disorders (DSM V criteria) whatever the subtype Stabilized from a point of view clinical and therapeutic Euthymic (score <7 at the Hamilton scale, and score <8 at Young's scale) Must have given their informed consent before their participation in the study Be right-handed (score> 14 on the laterality scale) For control group: Affiliated or entitled to a social security Must have given their informed consent before their participation in the study Be right-handed (score> 14 on the lateral scale) Aged 18 to 55 matched by age (± 5 years), sex, and on the study level of patients (years of schooling after primary school ± 2 years) Exclusion Criteria: For patients: Thymic acute decompensation Hamilton scale > 8, Young's scale > 9 Montreal Cognitive Assessment (MOCA) <26 History neurological pathology with cerebral impairment or serious somatic disease Disorders related to the use of a psychoactive substance, as defined by the DSM-V (abuse, dependence or withdrawal) within 6 months. IQ < 70 History of head trauma For control group: History of head trauma Neurological pathology with cerebral impairment or serious somatic disease Psychotropic treatment Disorders related to the use of a psychoactive substance, as defined by the DSM-V (abuse, dependence or withdrawal) IQ < 70

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: patients<br>Patients suffering bipolar affective disorders and who will perform cognitive tasks + IQ + MINI + experimental task | Behavioral: cognitive tasks + IQ + MINI<br>* Patients will perform different tasks: cognitive tasks : reaction time (Alert TEA, Zimmermann and Fimm, 2005) + Edinburgh laterality questionnaire (Oldfield,1971) + hamilton and young's scale (Tohen et al., 2009) + Montreal Cognitive Assessment (MoCA) (Nasreddine et al., 2005) + experimental task (approach/ avoidance and affordance task). Intelligence Quotient (IQ) test (PM38, Raven, 1960) Mini International Neuropsychiatric Interview (MINI, Van Vliet et al., 2006)<br>|
| Active Comparator: control group<br>Healthy volunteers (Control group) who will perform cognitive tasks + experimental task | Behavioral: cognitive tasks<br>* Healthy volunteers will perform only the cognitive tasks = reaction time alert TEA, Zimmermann and Fimm, 2005 + Edinburgh laterality questionnaire (Oldfield, 1971) + experimental task (approach/ avoidance and affordance task).<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| response time for avoidance and affordance task | Comparison of response time for avoidance and affordance task between patients and healthy volunteers. | Months 24 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| response time for affordance task | Comparison of response time for affordance task between patients and healthy volunteers. | Months 24 | 
| correlations with age at onset of the disease, the number of thymic decompensations and the existence of psychotic symptoms | These informations were collected of the medical file. | Months 24 | 
| response time and cognitive tests | Correlation between response time and cognitive tests of patients and healthy volunteers. | Months 24 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Bipolar affective disorders, Cognition, Emotion, Embodiment, Sensorimotor, Simulation