A Retrospective Clinical Registry of Peripheral Nerve Block

Study Overview
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Brief Summary
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Locorregional anaesthesia have been increased its role in different kind of surgeries, alone or combined with general anesthesia. Due to ultrasound, peripheral nerve blocks have been increased their importance in locoregional anaesthesia. They provide excellent intraoperative and postoperative analgesia, decreasing the need for intravenous opioids which increase postoperative nausea and vomiting which may prolong hospital stay. The primary study objective is to analyze retrospectively the use of peripheral nerve blocks in the current practice of a specialized regional anaesthesia division. This is an observational, retrospective and unicenter study. 1346 patients scheduled for the surgery needed a peripheral nerve block were enrolled.

Detailed Description
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Locorregional anaesthesia have been increased its role in different kind of surgeries, alone or combined with general anesthesia. Due to ultrasound, peripheral nerve blocks have been increased their importance in locoregional anaesthesia. They provide excellent intraoperative and postoperative analgesia, decreasing the need for intravenous opioids which increase postoperative nausea and vomiting which may prolong hospital stay. However, peripheral nerve blocks may be associated with postoperative complications, especially neurological ones. Classically, interscalene brachial plexus block produced a 100% incidence of phrenic nerve paralysis with resultant pulmonary compromise. Little literature has published a following of complications. The primary study objective is to analyze retrospectively the use of peripheral nerve blocks in the current practice of a specialized regional anaesthesia division. The secondary objectives are assessed the patients characteristics of our sample, local anaesthetic dose used, the peripheral nerve block operator, the nerve location technique, the surgery and the complication rate after peripheral nerve block. This is an observational, retrospective and unicenter study. 1346 patients scheduled for the surgery needed a peripheral nerve block were enrolled.

Official Title
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A Retrospective Clinical Registry of Peripheral Nerve Block: Current Practice and Complications

Conditions
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Postoperative Complications, Nerve Block, Regional Anesthesia

Intervention / Treatment
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* Procedure: Peripheral nerve block


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Every patient who needs a peripheral nerve block performed by Anestesia Department. Exclusion Criteria: Patient refusal of peripheral nerve block. Known allergy to amide local anaesthetic drugs Absolute contraindications to perform a peripheral nerve block as coagulopathy, active infection at the block site or severe respiratory background.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Peripheral nerve block Group<br>Every patient scheduled during 2011-2019 for the surgery needed a peripheral nerve block were enrolled. | Procedure: Peripheral nerve block<br>* Peripheral nerve block consists of the administration of a local anaesthetic into the nerves to inhibit nerve transmission in a specific part of the body. Ultrasound or Nerve stimulator could be used to locate the peripheral nerve. A needle is placed through the anatomical references to administer local anaesthetic around the peripheral nerve. Single-shot or continuous blocks are performed preoperatively and postoperatively as current practice in the surgery theatre. Using ultrasound, in-plane or out-plane approach could be performed. Peripheral nerve block provides excellent intraoperative and postoperative analgesia decreasing the need for intravenous pain drugs. Interscalene block, supraclavicular block, safene block, femoral block, BRILMA block are different kinds of peripheral nerve block using in the anaesthestic current practice.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Peripheral nerve block | This primary outcome is the type of peripheral nerve block performed | During procedure | 
| Incidence and frequency of Serious Adverse Events (SAE) | This primary outcome is the incidence, frequency and severity of Serious Adverse Events (SAE) as assessed by CTCAE v4.0 after peripheral nerve block. | From performing the peripheral nerve block to 1-year follow-up | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence and frequency of Postoperative neurological complications (PONC) | This secondary outcome is the incidence, frequency and severity of Postoperative neurological complications (PONC) as assessed by CTCAE v4.0 after peripheral nerve block. | From performing the peripheral nerve block to 1-year follow-up | 
| Local anesthetic used in peripheral nerve block | Local anesthetic type (FDA drug) used in peripheral nerve block performance | During procedure | 
| Local anesthetic dose used in peripheral nerve block | Local anesthetic dose (mg) used in peripheral nerve block performance | During procedure | 
| Local anesthetic volume used in peripheral nerve block | Local anesthetic volume (ml) used in peripheral nerve block performance | During procedure | 
| Nerve location technique used in peripheral nerve block | Type of nerve location technique (ultrasound, nerve stimulator or paresthesia techinique) used in peripheral nerve block performance | During procedure | 
| Peripheral nerve block operator | Anesthesiologist operator of peripheral nerve block (attending or trainee). | During procedure | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Regional Anesthesia, Postoperative neurological complications, Ultrasound, Nerve stimulator, Brachial Plexus Block