Electrohaemodynamic Activity in Epileptic Children : Combined Video-EEG and Near-infrared Spectroscopy (NIRS) Analysis

Study Overview
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Brief Summary
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Evaluate the contribution of multimodal high-resolution EEG-NIRS electrical and local haemodynamic analysis to spatial localization of epileptogenic foci

Detailed Description
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This study is designed to evaluate the contribution of multimodal high-resolution EEG-NIRS electrical and local haemodynamic analysis (HR-EEG, HR-NIRS) to spatial localization of epileptogenic foci in order to perform multimodal mapping and localization of interictal spikes (by HR-EEG source reconstruction) with the clinical prospects of guiding the SEEG electrode implantation strategy prior to surgery in children with drug-refractory partial epilepsy.

Official Title
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Electrohaemodynamic Activity in Epileptic Children: Combined Video-EEG and Near-infrared Spectroscopy (NIRS) Analysis

Conditions
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Epilepsy

Intervention / Treatment
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* Device: multimodal high-resolution EEG-NIRS


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Children between the ages of 6 and 18 years with drug-refractory partial epilepsy, presenting interictal spikes on standard EEG recordings. Exclusion Criteria: Children with a serious congenital malformation. Refusal from one of the parents or the child. Children with generalized epilepsy or diffuse interictal spikes. Children with severely impaired general status and vital functions. Children with dermatosis of the face or scalp. Children under the age of 6 years or adults over the age of 18 years.

Ages Eligible for Study
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Minimum Age: 6 Years
Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| symptomatic partial epilepsy<br>whose brain MRI is abnormal multimodal high-resolution EEG-NIRS | Device: multimodal high-resolution EEG-NIRS<br> <br> |
| not symptomatic partial epilepsy<br>whose brain MRI is normal multimodal high-resolution EEG-NIRS | Device: multimodal high-resolution EEG-NIRS<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| multimodal high-resolution EEG-NIRS | to evaluate the contribution of multimodal high-resolution EEG-NIRS electrical and local haemodynamic analysis (HR-EEG, HR-NIRS) to spatial localization of epileptogenic foci in order to perform multimodal mapping and localization of interictal spikes (by HR-EEG source reconstruction) with the clinical prospects of guiding the SEEG electrode implantation strategy prior to surgery in children with drug-refractory partial epilepsy. | Day 0 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Functional MRI | to analyse the temporal dynamics of haemodynamic changes surrounding epileptic spikes. | Day 0 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Video-EEG, near-infrared spectroscopy (NIRS)