Cytokine Changes After Colorectal Cancer Resection

Study Overview
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Brief Summary
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Based on our previous research, this study aims to determine reliable surgical stress response markers in patients undergoing radical resection of colorectal cancer.

Detailed Description
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Every surgical intervention represents a stress for patient's organism. During the operation, numerous changes in the patient's metabolism take place, that are termed surgical stress response. Leading cause of surgical stress response is tissue destruction that always accompanies operations. Surgical stress response is effected through activation of hypothalamus-pituitary-adrenal axis and through sympathetic activation. The consequences of surgical stress response are numerous. Surgical stress response is essential to uneventful postoperative recovery. On the other hand, excessive surgical stress response may lead to serious postoperative complications, such as heart and kidney failure, venous thrombosis, disruption of operative wound and wound infection. In prior studies the investigators have shown the kinetics of postoperative serum interleukin changes after radical resection of gastric cancer. This study aims at determining reliable markers of surgical stress response severity in patients undergoing radical resection of colorectal cancer.

Official Title
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Postoperative Serum Cytokine Changes After Radical Resection of Colorectal Cancer

Conditions
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Colorectal Cancer

Intervention / Treatment
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* Procedure: colorectal cancer resection


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Pathohistologically verified colorectal cancer Exclusion Criteria: Distant metastases noticed before or during surgery History of autoimmune diseases or immunodeficiencies Use of immunomodulatory drugs within 1 year prior to surgery

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Colorectal cancer patients<br>Patients with pathohistologically verified colorectal cancer or adenoma with epithelial dysplasia | Procedure: colorectal cancer resection<br>* Open radical resection of colorectal cancer, according to oncological principals, depending on the tumor site<br>* Other names: Rectosigmoid resection;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative changes of serum cytokine levels | Serum cytokine levels will be determined at 1st, 2nd and 7th postoperative day and compared to preoperative values. | 1 day, 2 days and 7 days postoperatively | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Early postoperative complications |  | Within one month after surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Colorectal cancer, Surgical stress response, interleukins