Prospective Assessment of Adolescent Drinking Trajectories With Computer-Assisted Self-administration of Ethanol (CASE)

Study Overview
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Brief Summary
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The Computer-Assisted Self-administration of Ethanol (CASE)will be administered twice, at the ages 18 and 20, in a prospective study of 80 adolescents living in the Dresden area. The sample will be recruited for a differential family history of alcoholism (FHA) and gender, with inventories of alcohol use disorder (AUD) symptoms and personal recent drinking history (RDH) obtained prior to each CASE session.

Official Title
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Collaboration on Alcohol Self Administration in Adolescents and Young Adults - Specific Aim 1: Assess the Initial Slope of Adolescent Drinking Trajectories, Beginning at the Age of Eighteen

Conditions
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Alcoholism

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: (a) male and female Caucasian volunteers aged 18 years/0 months to 19 years/11 months; (b) written informed consent by the subject; (c) habitual social drinking during the two months preceding participation, defined by at least one drinking day in any two weeks-interval; (d) at least one prior experience of alcohol intoxication (e) being able to abstain from tobacco use for four hours without developing nicotine withdrawal symptoms; (f) effective contraception in female participants; (g) consenting to abstain from any illegal substance use for 2 weeks prior to participation; (h) living within 15 km (9.5 miles) from downtown Dresden; (i) sufficient information concerning alcohol use in both parents and in at least four second-degree relatives Exclusion Criteria: (a) prior medical treatment due to alcohol use; (b) current or prior history of any serious disease, including CNS, cardiovascular, respiratory, gastrointestinal, hepatic, renal, endocrine, alcohol or drug dependence, but not alcohol abuse; (c) current history of Axis-I psychiatric illness, including premenstrual dysphoric disorder; (d) current or prior history of alcohol-induced flushing reactions; (e) positive urine screen for cannabinoids, cocaine, amphetamines, opiates, or benzodiazepines; (f) light or non-drinkers: averaging less than 2 standard drinks per week in the preceding two months; (g) intention to become pregnant (h) pregnancy or positive urine pregnancy screening or breast-feeding; (i) any alcohol intake on the test day or the day before; (k) use of medications known to interact with alcohol within 2 weeks of the study; (l) positive hepatitis or HIV at screening, provided the subject consented to these tests

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 19 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Alcohol consumption | Alcohol consumption, as measured by a Timeline Followback Interview and experimental Self-Administration. | 2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Alcohol Use Disorders |  | 2 years |