Sleep Apnea-Hypopnea Syndrome and the Pathogenesis of Obesity

Study Overview
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Brief Summary
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The hypothesis of the study is the following: Patients with sleep apnea-hypopnea syndrome have different pattern in the secretion of hormones. The chronic sleep disorganization that suffer patients with sleep apnea-hypopnea syndrome (SAHS) may affect the central mechanisms that regulate nutritive behavior and energetic balance, causing an alteration in the secretion of hormones that favour the appearance and/or development of obesity.

Detailed Description
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OBJECTIVES: To compare the plasmatic profiles of different hormones and neuropeptides, related with weight control, metabolism and intake in patients with SAHS as well as in selected control subjects according to weight. DESIGN: Multicenter, prospective and controlled study. 40 patients with SAHS will be included as well as 40 control subjects. METHODS: To all subjects included in the study, the following procedures will be performed: Medical History; Anthropometric variables (height, weight, Body Mass Index; Somnolence evaluation using the Epworth scale; Conventional Polysomnography (PSG); Determination every four hours during a 24 hours period of the levels of leptin adiponectin, resistin, insulin, PCR, etc. Conventional biologic evaluation; Patients will be re-evaluated after three months of treatment with CPAP.

Official Title
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Sleep Apnea-Hypopnea Syndrome and the Pathogenesis of Obesity

Conditions
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Sleep Apnea, Obesity

Intervention / Treatment
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* Device: CPAP (Continuous Positive Airway Pressure)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Apnea-Hypopnea Index > 15 Body Mass Index < 27 or > 30 Kg/m2 Exclusion Criteria: Presence of any chronic disease Drug addiction and/or alcoholism Refusal to sign informed consent

Ages Eligible for Study
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Minimum Age: 25 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: CPAP (Continuous Positive Airway Pressure)|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| OBJECTIVES: To compare the plasmatic profiles of different hormones |  |  | 
| and neuropeptides, related with weight control, metabolism and intake |  |  | 
| in patients with SAHS as well as in selected control subjects according |  |  | 
| to weight. |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| CPAP (Continuous Positive Airway Pressure) effect on studied variables |  |  | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Sleep Apnea, Obesity, Neuropeptides, Hormones