Effect of Antihypertensive Drugs on Glaucoma Patients

Study Overview
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Brief Summary
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It has been reported that among Asian non-glaucomatous, antihypertensive medications were associated with retinal nerve fiber layer and ganglion cell-inner plexiform layer thickness. In order to explore whether antihypertensive medications would influence the neuropathy among glaucomatous population, we designed a cross-sectional observational study to analyze the retinal status among glaucoma patients with use of antihypertensive medication.

Detailed Description
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we designed a cross-sectional obeservational study to analyze the retinal status among glaucoma patients with use of hyertensive medication.

Official Title
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Effect of Antihypertensive Drugs on Glaucoma Patients

Conditions
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Glaucoma

Intervention / Treatment
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* Other: no intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age no less than 18 years best corrected visual acuity better than decimal 0.3 Exclusion Criteria: secondary glaucoma secondary hypertension glaucoma-related operation history pregnancy or lactation period uncooperative with retinal examination severe opacity with refracting media in eye severe retinal diseases and neuropathy congenital retinal optic nerve abnormality other systemic diseases that influence hypertension and glaucoma assessment

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| healthy control<br>adults without glaucoma history or hypertension history | Other: no intervention<br>* no intervention, only measurement of blood pressure, intraocular pressure, hypertensive history questionnaire, retinal imaging, optical coherence tomography examination etc..<br>|
| glaucoma patients<br>adults with primary glaucoma history; without glaucoma-related operation history; without hypertension history | Other: no intervention<br>* no intervention, only measurement of blood pressure, intraocular pressure, hypertensive history questionnaire, retinal imaging, optical coherence tomography examination etc..<br>|
| hypertension patients<br>adults with primary hypertension history; without glaucoma history | Other: no intervention<br>* no intervention, only measurement of blood pressure, intraocular pressure, hypertensive history questionnaire, retinal imaging, optical coherence tomography examination etc..<br>|
| glaucoma+hypertension<br>adults with primary glaucoma history and primary hypertension history; without glaucoma-related operation history | Other: no intervention<br>* no intervention, only measurement of blood pressure, intraocular pressure, hypertensive history questionnaire, retinal imaging, optical coherence tomography examination etc..<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| retinal nerve fiber layer thickness | retinal nerve fiber layer thickness measured by optical coherence tomography | within 3 months from recruitment |