Brain Imaging Studies of the Effects of Cocaine Abstinence

Study Overview
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Brief Summary
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This study evaluates theories regarding cocaine abstinence which propose that increased presynaptic and postsynaptic dopamine activity and increased serotonin activity are associated with abstinence in cocaine dependent subjects at the beginning and three to six months after a treatment program. We are using positron emission tomography (PET), Magnetic Resonance Imaging (MRI) and diffusion tensor imaging (DTI) in cortical and subcortical areas in a series of brain imaging studies testing these theories of abnormalities in the dopamine and serotonin system for cocaine addiction by examining the distribution of 18F-fallypride, 18F-altanserin, and FDG. We are evaluating genetic theories associated with cocaine addiction through the examination of genetic markers and functional genomics.

Official Title
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Brain Imaging Studies of the Effects of Cocaine Abstinence

Conditions
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Substance Abuse Disorder

Intervention / Treatment
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* Radiation: PET scan
* Other: fMRI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Inclusion criteria include: Subjects must be male or female and English speaking. Subjects must be adults with a history of diagnosis of cocaine dependence disorder (n=20) who are under supervised treatment for dependence or normal control (n=10). Subjects must be between 21 to 65 years of age. Exclusion Criteria: Exclusion criteria include: Suicidality or psychosis. Head injury, kidney or bladder disease or any unstable or serious medical conditions. Prior exposure to radiation (including diagnostic or treatment x-rays), which might cause subjects to exceed standard guidelines. Unwillingness or inability to adhere to the requirements of the study. Donation or large loss of blood (>400 ml) within the past month. Current or very recent illnesses, painful conditions or other disorders, which in the judgment of the investigators, might invalidate the scientific goals of the study or pose undesirable difficulties or risks for subjects. Pregnancy or breast feeding. Individuals who would be unable to undergo a magnetic resonance imaging (MRI) scan, for example, individuals who suffer from claustrophobia, or who have metal clips in their body, metallic prostheses (i.e., replacement body parts, such as a hip joint), a pacemaker, or other pieces of metal in their body (shrapnel, metal filings, etc.).

Ages Eligible for Study
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Minimum Age: 21 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>Cocaine abstinent group | Radiation: PET scan<br>* positron emission tomography PET scan<br>Other: fMRI<br>* functional magnetic resonance imaging fMRI<br>|
| 2<br>Normal healthy control group | Radiation: PET scan<br>* positron emission tomography PET scan<br>Other: fMRI<br>* functional magnetic resonance imaging fMRI<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| PET scans, fMRI scans |  | The beginning and three to six months after a treatment program | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cocaine abstinence, PET scan