Variable Resistance Training in Patients With Osteoarthrosis of the Knee

Study Overview
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Brief Summary
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This is a randomized controlled trial investigating the effect of variable load training in patients with knee osteoarthrosis. The intervention will consist of resistance training with variable load in knee extension- and flexion. The control group will receive conventional strength training with rubber band. Outcome measures will be the Knee Osteoarthrosis Outcome Score, functional capacity measured in a sit to stand test, 30m. pace walk and a 9 step stair climb test. Additionally isometric strength in knee flexion- and extension will be measured.

Official Title
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Variable Resistance Training Versus Conventional Rubber Band Training: Effects on Functional Capacity and Strength in Patients With Osteoarthrosis of the Knee

Conditions
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Resistance Training

Intervention / Treatment
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* Other: Variable load training
* Other: Conventional strength training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Knee pain and minimum three of the following >50 years morning stiffness < 30 min crepitation bone tenderness bone osteophytes absence of inflammation Exclusion Criteria: Other causes of symptoms to the knee

Ages Eligible for Study
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Minimum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Variable load training<br>The participants will be training two times per week in 10 weeks. Training will consist of variable load training in knee flexion- and extension. Training will be based on symptoms in isometric strength at five different angles of flexion- and extension. | Other: Variable load training<br>* Based on symptoms/strength measured in an isometric maximum strength test at five different angles of knee flexion- and extension, participants will be training with variable load during both concentric and excentric phase of the dynamic movement. Initially participants will start at 40% of symptom limited isometric strength, this will increase to 50% during the training period.<br>|
| Active Comparator: Conventional strength training<br>The participants will be training two times per week in 10 weeks. Training will consist of a training programme consisting of strength training with rubber bands for hip and knee. | Other: Conventional strength training<br>* Conventional strength training with rubber bands in knee flexion- and extension, additionally hip abduction- and adduction.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in self reported knee function | Knee Osteoarthrosis Outcome Score (100-0, 100 indicating no symptoms and 0 indicating extreme symptoms) | At baseline and 10 weeks follow up | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in functional capacity | Sit to stand test | At baseline and 10 weeks follow up | 
| Change in isometric strength | Isometric strength in knee flexion- and extension | At baseline and 10 weeks follow up | 
| Change in functional capacity | 30m pace walk | At baseline and 10 weeks follow up | 
| Change in functional capacity | 9 step stair climb test | At baseline and 10 weeks follow up |