Clinical and Live Birth Rates After Following Long Antagonist Protocol Versus Long Agonist Protocol

Study Overview
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Brief Summary
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A prospective study of the evaluation of the clinical IVF (in vitro fertilization) results after following Long Antagonist protocol for Controlled Ovarian Stimulation (COS) versus following Long Agonist protocol

Detailed Description
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A prospective study of the clinical results in women who followed the Long Antagonist protocol for Controlled Ovarian Stimulation (COS) versus women who followed Long Agonist protocol, in an In Vitro Fertilization (IVF) try. In particular, the Clinical Pregnancy Rates (CPR) and Live Birth Rates (LBR) were estimated for the two groups of patients. The number of the formed blastocysts was also measured in each group of patients.

Official Title
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Clinical and Live Birth Rates After Controlled Ovarian Stimulation With the Long Antagonist Protocol Versus the Long Agonist Protocol

Conditions
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Pregnancy, Ovarian

Intervention / Treatment
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* Diagnostic Test: Clinical Pregnancy Rate


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: primary infertility age 18-39 years; body mass index (BMI) 18-29kg/m2; regular menstrual cycle of 26-35days, presumed to be ovulatory; early follicular- phase serum concentration of FSH within normal limits (1-12 IU/l). Exclusion Criteria: women with diabetes and other metabolic disease women with heart disease, QT prolongation,heart failure elevated liver enzymes, liver failure, hepatitis women with inflammatory or autoimmune disease abnormal karyotype; polycystic ovarian syndrome, endometriosis stage III/IV; history of being a 'poor responder', defined as >20 days of gonadotrophin in a previous stimulation cycle, or any previous cancellation of a stimulation cycle due to limited follicular response, or development of less than 4 follicles 15 mm in a previous stimulation cycle; history of recurrent miscarriage; severe OHSS in a previous stimula- tion cycle or any contraindication for the use of gonadotrophins.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 39 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Long Antagonist Protocol<br>Clinical Pregnancy Rate, Live Birth Rate and Blastulation Rate of patients who followed Long Antagonist Protocol for Controlled Ovarian Stimulation. | Diagnostic Test: Clinical Pregnancy Rate<br>* The Clinical Pregnancy, Live Birth Rate and Blastulation Rate according to the protocol of COS<br>|
| Long Agonist Protocol<br>Clinical Pregnancy Rate and Live Birth Rates and Blastulation Rate of patients who followed Long Agonist Protocol for Controlled Ovarian Stimulation. | Diagnostic Test: Clinical Pregnancy Rate<br>* The Clinical Pregnancy, Live Birth Rate and Blastulation Rate according to the protocol of COS<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical Pregnancy Rate according to stimulation protocol | Clinical Pregnancy Rate according to stimulation protocol | 6 weeks to 42 weeks after embryo transfer | 
| Number of formed blastocysts in each group of patients | The number of the formed blastocysts in each group of patients according to the COS protocol | 5 days after the OPU day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Live Birth Rate according to stimulation protocol | Live Birth Rate according to stimulation protocol | 6 weeks to 42 weeks after embryo transfer | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Long Antagonist, Long agonist, clinical pregnancy rate, live birth rate, ovarian stimulation, IVF