Brain Bases of Natural Scenes's Visual Perception of Natural Scenes

Study Overview
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Brief Summary
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Using the available data from psychophysics, cellular electrophysiology and functionnal neuroanatomy of visual pathway, current models of visual recognition suppose that the perception of scenes start with a parallel extraction of differents elementary visual characteristics to different spatial frequencies according to a default processing principle named : 'coarse-to-fine'. According to this principle, the visual scene's analysis would be decomposed in two steps. Fisrt, the fast analysis of the global information borne by low frequency of the scene will provide an overview of the scene's structure and would enable a first perceptive categorisation which would be then refined, approved or denied by the latest analysis of the most local, detailed and precise information, carried by the very high spatial frequency of the scene. The research carried out since several years is preparing a biologically plausible model and to find brain bases by different imaging techniques among healthy subjects but also patients with a brain lesion and patients with a peripheral lesion. The main goal of this Magnetic Resonance Imaging study is to find brain bases of natural scenes's visual perception of the natural scenes. Three studies in Magnetic Resonance Imaging will be conducted, during which subjects will have to categorize pictures of natural scenes filtered in spatial frequencies. The outcome of this study will allow to refine models of visual recognition, most of them based on analysis of spatial frequencies.

Official Title
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Brain Bases of Visual Perceptionnatural Scenes of Natural Scenes.

Conditions
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Healthy Volunteer

Intervention / Treatment
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* Other: Evaluation of visual function
* Other: Magnetic Resonance Imaging


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria for young adults : Subjet over 18 years and less than 30 years Affiliation to a social security Free signed consent Medical exam done before participation to the study Normal or corrected visual acuity Exclusion Criteria four young adults : Counter-argument to MRI Pregnant, breast-feeding or parturient women Adults non protected or unable to express their consent Adults protected Important earing or visual disorder Neuropsychiatric disorder current or past passée ou présente (exept benign epilepsy) Severe affection on a general level (cardiac, respiratory, hematologic, renal, hépatic, cancerous) Drug treatment in progress (exept anti-epileptic drug) likely to de modulate brain activity Inclusion Criteria for old adults : Subjet over 50 years Affiliation to a social security Free signed consent Medical exam done before participation to the study Normal or corrected visual acuity Exclusion Criteria four old adults : Counter-argument to MRI Pregnant, breast-feeding or parturient women Adults non protected or unable to express their consent Adults protected Important earing or visual disorder Neuropsychiatric disorder current or past passée ou présente (exept benign epilepsy) Severe affection on a general level (cardiac, respiratory, hematologic, renal, hépatic, cancerous) Drug treatment in progress (exept anti-epileptic drug) likely to de modulate brain activity Inclusion Criteria for children : Children between 4 and 12 years Affiliation to a social security Free signed consent Medical exam done before participation to the study Normal or corrected visual acuity Exclusion Criteria four children : Counter-argument to MRI Important earing or visual disorder Important development disorder and/or acquisitions identified by parents and/or school teachers Neuropsychiatric disorder current or past passée ou présente (exept benign epilepsy) Severe affection on a general level (cardiac, respiratory, hematologic, renal, hépatic, cancerous) Drug treatment in progress (exept anti-epileptic drug) likely to de modulate brain activity

Ages Eligible for Study
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Minimum Age: 4 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Expérience 1<br>Brain bases of spatial frequencies treatment 30 young adults, 20 old adults 20 children between 4 and 6 years, 20 children between 6 and 12 years and 20 young adults | Other: Evaluation of visual function<br> <br> Other: Magnetic Resonance Imaging<br> <br> * Other names: MRI;|
| Other: Expérience 2<br>Brain bases of Computer to Film (CtF) analysis 30 young adults, 20 old adults | Other: Evaluation of visual function<br> <br> Other: Magnetic Resonance Imaging<br> <br> * Other names: MRI;|
| Other: Expérience 3<br>Part of parahippocampal gyrus in Computer to Film (CtF) analysis 30 young adults, 20 old adults. | Other: Evaluation of visual function<br> <br> Other: Magnetic Resonance Imaging<br> <br> * Other names: MRI;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Identify brain bases of natural scenes's visual perception of the natural scenes | Evaluation 1 = Visual tasks Experience 1 : Brain bases of spatial frequencies treatment Experience 2 : Brain bases of Computer to Film (CtF) natural scenes analysis MRI exam Experience 3 : Part of parahippocampal gyrus in Computer to Film (CtF) natural scenes analysis MRI exam About 30 minutes Evaluation 2 = Retinotopy : only adults that have shown activations inside occipital cortex during evaluation 1 MRI exam about 50 minutes | About 80 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Natural scenes, Brain bases, Visual perception, MRI