Heterogeneity of Metastatic Neuroendocrine Tumors as Determined With 18F-dihydroxyphenylalanine-PET /CT, a Retrospective Analysis

Study Overview
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Brief Summary
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In an individual cancer patient extensive genetic and phenotypic variation exists between and within tumor lesions. Tumour load in NET patients can be measured with fluorine-18-L-dihydroxyphenylalaninepositron emission tomography (18F-DOPA-PET) scan. This aim of the study is to investigate heterogeneity between tumor lesions within patients with intestinal NET by determining the differences in tracer uptake measured on a 18F- DOPA-PET scan retrospectively.

Detailed Description
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In an individual cancer patient extensive genetic and phenotypic variation exists between and within tumor lesions. Tumour load in NET patients can be measured with fluorine-18-L-dihydroxyphenylalanine positron emission tomography (18F-DOPA-PET) scan. This aim of the study is to investigate heterogeneity between tumor lesions within patients with intestinal NET by determining the differences in tracer uptake measured on a 18F- DOPA-PET scan in retrospect.

Official Title
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Heterogeneity of Metastatic Neuroendocrine Tumors as Determined With 18F-dihydroxyphenylalanine-PET /CT, a Retrospective Analysis

Conditions
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Neuroendocrine Tumors

Intervention / Treatment
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* Other: Metastasized intestinal NET


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age ≥18 years diagnosis of intestinal NET diagnosed by a dedicated NET specialist more than one positive lesion on the 18F-DOPA-PET scan. available CT-scan within 6 months before or after the 18F-DOPA-PET-scan. Exclusion Criteria: no clinical data available at the UMCG, besides the results of the DOPA PET scan.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Metastasized intestinal NET<br>We will select the 18F- DOPA-PET scans conducted in the Universtiy Medical Center of Groningen (UMCG) of adult patients with a metastasized intestinal NET between February 2014 until November 2015. Only patients of whose clinical data are available within the UMCG are included. | Other: Metastasized intestinal NET<br>* This is an observational study<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| tracer uptake in tumor lesions within patients with intestinal NET | The difference in tracer uptake of tumor lesions within patients with intestinal NET measured on a 18F- DOPA-PET scan. | at the day of scan | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| tracer uptake in tumor lesions within patients with intestinal NET adjusted for uptake of background organ | The difference in tracer uptake of tumor lesions adjusted for uptake of background organ within patients with intestinal NET measured on a 18F- DOPA-PET scan. | at the day of scan |