Search for BIO Diagnostic and Prognostic Markers in Adult VAScularitis

Study Overview
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Brief Summary
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To date, there are no reliable diagnostic blood markers of adult vasculitis. To date, the diagnosis of vasculitis is based on invasive procedure, biopsy of affected tissues potentially at risk of complication . In addition, there are no reliable biomarkers to predict the evolution of vasculitis (relapse, refractory form ...) necessary for the management of patients (type of treatment, duration ..) Prospective study, monocentric (CHU de Tours), non-interventional, aimed at finding diagnostic and prognostic biomarkers (both metabolomic and immunologic) in adult vasculitis patients.

Detailed Description
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Specimen will be collected at diagnosis, month 1, month 3, and month12 and at the time of a possible relapse. 14 ml of additional blood during a blood puncture made for routine care will be collected at each visit as well as clinical data.

Official Title
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Search for BIO Diagnostic and Prognostic Markers in Adult VAScularitis

Conditions
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Vasculitis

Intervention / Treatment
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* Other: Sampling


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age > 16 years Active vasculitis, new diagnosis or relapse IgA vasculitis ANCA vasculitis Giant cell arteritis Exclusion Criteria: Person who has objected to the processing of data Pregnant woman Patient positive for HIV, HBV, HCV Treatment in the previous month with corticosteroids, immunosuppressive drugs or biotherapy. Patient unable to understand the information leaflet Adult under guardianship or curatorship

Ages Eligible for Study
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Minimum Age: 16 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| patients with vascularitis<br>Two additional 7ml EDTA tubes of blood are taken from the same blood puncture as during routine follow-up at several points in the follow-up | Other: Sampling<br>* 4 blood sampling per patient and an additional one in case of relapse<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| cytokine/chemokine/metabolite concentrations | Analysis by méthod Luminex | Baseline | 
| cytokine/chemokine/metabolite concentrations | Analysis by méthod Luminex | Month 1 | 
| cytokine/chemokine/metabolite concentrations | Analysis by méthod Luminex | Month 3 | 
| cytokine/chemokine/metabolite concentrations | Analysis by méthod Luminex | Month 12 | 
| cytokine/chemokine/metabolite concentrations | Analysis by méthod Luminex | date of relapse assessed up to 12 months | 
| percentage of different non-conventional T cell populations | study by flow cytometry | Baseline | 
| percentage of different non-conventional T cell populations | study by flow cytometry | Month 1 | 
| percentage of different non-conventional T cell populations | study by flow cytometry | Month 3 | 
| percentage of different non-conventional T cell populations | study by flow cytometry | Month 12 | 
| percentage of different non-conventional T cell populations | study by flow cytometry | date of relapse assessed up to 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| cytokine/chemokine/metabolite concentrations | identify a metabolomic blood profile for the prognosis of vasculitis | baseline | 
| cytokine/chemokine/metabolite concentrations | identify a metabolomic blood profile for the prognosis of vasculitis | Month 1 | 
| cytokine/chemokine/metabolite concentrations | identify a metabolomic blood profile for the prognosis of vasculitis | Month 3 | 
| cytokine/chemokine/metabolite concentrations | identify a metabolomic blood profile for the prognosis of vasculitis | Month 12 | 
| cytokine/chemokine/metabolite concentrations | identify a metabolomic blood profile for the prognosis of vasculitis | date of relapse assessed up to 12 months | 
| percentage of different non-conventional T cell populations | identify an immunological blood profile for the prognosis of vasculitis | baseline | 
| percentage of different non-conventional T cell populations | identify an immunological blood profile for the prognosis of vasculitis | Month 1 | 
| percentage of different non-conventional T cell populations | identify an immunological blood profile for the prognosis of vasculitis | Month 3 | 
| percentage of different non-conventional T cell populations | identify an immunological blood profile for the prognosis of vasculitis | Month 12 | 
| percentage of different non-conventional T cell populations | identify an immunological blood profile for the prognosis of vasculitis | date of relapse assessed up to 12 months | 
| metabolomic pathway | Identify a metabolomic pathway involved in the pathophysiology of vasculitis that could be a target for therapy. | baseline | 
| metabolomic pathway | Identify a metabolomic pathway involved in the pathophysiology of vasculitis that could be a target for therapy. | Month 1 | 
| metabolomic pathway | Identify a metabolomic pathway involved in the pathophysiology of vasculitis that could be a target for therapy. | Month 3 | 
| metabolomic pathway | Identify a metabolomic pathway involved in the pathophysiology of vasculitis that could be a target for therapy. | Month 12 | 
| metabolomic pathway | Identify a metabolomic pathway involved in the pathophysiology of vasculitis that could be a target for therapy. | date of relapse assessed up to 12 months | 
| immunological pathway | Identify an immunological pathway involved in the pathophysiology of vasculitis that could be a target for therapy. | baseline | 
| immunological pathway | Identify an immunological pathway involved in the pathophysiology of vasculitis that could be a target for therapy. | Month 1 | 
| immunological pathway | Identify an immunological pathway involved in the pathophysiology of vasculitis that could be a target for therapy. | Month 3 | 
| immunological pathway | Identify an immunological pathway involved in the pathophysiology of vasculitis that could be a target for therapy. | Month 12 | 
| immunological pathway | Identify an immunological pathway involved in the pathophysiology of vasculitis that could be a target for therapy. | date of relapse assessed up to 12 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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biomarkers, diagnosis, prognosis