Magnetic Resonance Elastography in Hydrocephalus

Study Overview
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Brief Summary
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The purpose of this project is to assess the utility of a new magnetic resonance technique called magnetic resonance elastography (MRE) in the non-invasive diagnosis of normal pressure hydrocephalus. The investigators hypothesize that MRE produces a unique imaging signature for hydrocephalus that distinguishes the disease from the normal (non-hydrocephalic) but atrophied brain, a distinction not possible with conventional MR imaging studies that are presently available.

Official Title
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Magnetic Resonance Elastography in Hydrocephalus

Conditions
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Hydrocephalus

Intervention / Treatment
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* Device: MRE


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age >21; One or more of the following complaints: memory loss/dementia, urinary incontinence, or progressive gait disturbance Ventriculomegaly defined as temporal horn width >2 mm or a FH:ID ratio>30% on computed tomography or MRI, where FH is the maximal distance between the frontal horns and ID is the internal diameter from inner table to inner table of the skull at this level (Greenberg) A diagnosis of any adult onset hydrocephalus (NPH, post-traumatic, post-hemorrhagic, obstructive, or idiopathic) will be considered for enrollment in this study Exclusion Criteria: Implanted neuro-stimulator or cardiac pacemaker Known coagulopathy; major organ dysfunction End-stage congestive heart failure Oxygen-dependent pulmonary disease, hepatic cirrhosis, or dialysis- dependent renal failure; or other condition which, according to the assessment of the treating surgeon or anesthesia team Precludes consideration of elective surgery Patients who may be pregnant will be excluded from this study as well

Ages Eligible for Study
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Minimum Age: 45 Years
Maximum Age: 95 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: MRE<br> | Device: MRE<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mean shear modulus | The primary outcome measure will be mean shear modulus determined from pre-operative (and pre-drain placement) MRE in patients who demonstrate clinical improvement with trial CSF drainage versus patients who do not demonstrate improvement. | 15 Years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pre-operative (and pre-drain placement) shear modulus in the experimental group will be compared with various assessments of clinical improvement after VP shunting. | Secondary outcomes will compare pre- and post-drain MRE shear moduli with ventricular size and intracranial pressure. | 15 Years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Hydrocephalus