Identifying Characteristic Signature of Attention Deficit / Hyperactivity Disorder (ADHD) and Ritalin Treatment

Study Overview
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Brief Summary
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In this study we try to identify the signature of brain activity in the EEG of attention deficit disorder (ADHD) patients compared to healthy subjects under different doses of Ritalin (methylphenidate) treatment.

Detailed Description
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In this study we try to identify the signature of brain activity in the EEG of attention deficit disorder (ADHD) patients compared to healthy subjects under different doses of Ritalin (methylphenidate) treatment. All subjects will undergo 1-4 EEG sessions. In each session we will use a different dose of Ritalin or placebo. A detailed neuropsychological tests will be done during the EEG recording. A powerful machine-learning techniques will be used in order to find a specific signature of ADHD and Ritalin treatment in the EEG recording.

Official Title
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Identifying Characteristic Signature of Brain Activity of Electroencephalogram Records in Attention Deficit / Hyperactivity Disorder (ADHD) and Ritalin Treatment

Conditions
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Attention Deficit Hyperactivity Disorder

Intervention / Treatment
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* Drug: Ritalin
* Drug: Placebo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy subjects, aged 18-50 years. Subjects aged 18-50 years diagnosed with ADHD and treated with Ritalin regularly (at least once a week). Exclusion Criteria: Patients previously diagnosed as suffering from a brain disease except for ADHD. Patients after traumatic head injury. Patients who are unable to express their consent to participate in the study.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Ritalin<br>Ritalin treatment at different doses | Drug: Ritalin<br>* Patients with ADHD and healthy subjects will be examined under Ritalin or placebo<br>|
| Placebo Comparator: Placebo<br>Two meetings, one of which will be given a placebo and the other will be given a low dose of Ritalin, randomly. | Drug: Placebo<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Resting oscillation activity and Event-related-Potentials in Attention Deficit / Hyperactivity Disorder (ADHD) and healthy subjects. | The primary outcome measure is the difference in the analysis of EEG recording (for example, resting oscillation activity and Event-related-Potentials) in Attention Deficit / Hyperactivity Disorder (ADHD) vs. healthy subjects. | 2 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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EEG Attention Deficit / Hyperactivity Disorder (ADHD) Ritalin machine learning