Congenital Uterine Anomalies & Pregnancy in Polycystic Ovarian Syndrome

Study Overview
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Brief Summary
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Prospective research in which patients who applied to UUTF Gynecology and Obstetrics ART center for the treatment of infertility (inability to conceive despite one year of unprotected sexual intercourse), who will undergo IVF due to PCOS and unexplained infertility

Detailed Description
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As of 01/10/2020, IVF cycles of patients with PCOS (n = 105) and unexplained infertility (n = 105) who have applied to Bursa Uludag University Gynecology and Obstetrics Department, Reproductive Treatments Center, will be included in the study. Demographic data of all patients (age, BMI, smoking), presence of hyperandrogenism findings such as systemic diseases, hirsutism, alopecia, FSH, LH, LH/FSH ratio, estradiol levels, pregestational serum AMH levels, uterine anomalies detected by transvaginal USG or hysterosalpingography, controlled ovarian hyperstimulation protocols and doses; Besides, DHEA-S, Free Testosterone, 17-OH Progesterone levels will be recorded in patients diagnosed with PCOS. All these data are routine laboratory and imaging parameters of patients who underwent in vitro fertilization in our UYTE center. Pregnancy results of the patients (biochemical pregnancy, anembryonic pregnancy, abortion, clinical pregnancy, live birth), perinatal results and complications during clinical pregnancy, delivery ways, and newborn APGAR scores will be recorded. Results will be compared with patients in the control group diagnosed with unexplained infertility.

Official Title
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Investigation of the Effect of Serum Androgen and Anti-Mullerian Hormone Levels on the Frequency of Müllerian Anomalies and Pregnancy Outcomes in Patients With Polycystic Ovarian Syndrome Undergoing Invitro Fertilization

Conditions
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Mullerian Anomaly of Uterus, Nec

Intervention / Treatment
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* Diagnostic Test: Ultrasound and Hysterosalpingography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Being in the age range of 20-40 Need for an assisted reproductive method due to PCOS or unexplained infertility Exclusion Criteria: <20 years or >40 years Detecting a cause for infertility other than PCOS

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Study Group<br>Infertile patients due to polycystic ovarian syndrome | Diagnostic Test: Ultrasound and Hysterosalpingography<br>* Ultrasound and Hysterosalpingography<br>|
| Control Group<br>Infertile patients due to unexplained infertility | Diagnostic Test: Ultrasound and Hysterosalpingography<br>* Ultrasound and Hysterosalpingography<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The rate of Mullerian Abnormality | ESHRE&ESGE uterine abnormality classification | One year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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mullerian anomaly, PCOS, antimullerian hormone