The China Longitudinal Aging Study of Cognitive Impairment

Study Overview
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Brief Summary
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Alzheimer's disease (AD) and Vascular dementia (VaD) have become common diseases in the elderly. The burden of dementia is rising in China, with major medical, social and economic impacts. To address this important public health problem, cohort study on elderly cognitive disorders should be carry out. The methods of early prevention, early diagnosis and early treatment the cognitive disorders in elderly should be found to reduce the burden of the social and economic issue due to dementia. At present, the international corresponding guidelines have taken gene and brain imaging biomarkers as important indicators of dementia pathogenesis research, accurate diagnosis and targeted intervention. Based on the above understanding, the study carry out the population cohort study based on accurate diagnosis and construct the high standard information and sample bank. The study will establish the standard and quality system of geriatric cognitive disorders cohort study (unified standards and norms). The study will integrate the standard biological samples stratified acquisition function module (homogeneity and precision) of elderly cognitive disorders, and complete the construction of biological samples bank and clinical diagnosis and treatment information database. The study will apply and develop brain structural and pathological imaging technology to support precision diagnosis of senile cognitive disorders. The study will evaluate whether peripheral nerve degeneration can predict central nervous system degeneration based on the large cohort of elderly study. In addition, The study will make an effective supplement the sample bank construction of Shanghai Mental Health Center.

Detailed Description
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The neuropsychological test battery are used to access the cognitive function of subjects in the study. The brain MRI and biochemical examination will be done in the screening period. The samples such as plasma, serum, urine and faeces et al. of the subjects will be collected in the study.

Official Title
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Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine

Conditions
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Mild Cognitive Impairment, Alzheimer Disease, Dementia, Vascular, Dementia With Lewy Bodies, Dementia Frontal, Depression, Anxiety

Intervention / Treatment
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* Other: Naturalistic observation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: registered residents in the community; ≥ 60 years; without schizophrenia or mental retardation; be able to communicate and accept physical and cognitive examinations Exclusion Criteria: blind deaf mute

Ages Eligible for Study
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Minimum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Neurocognitive disorder<br>Dementias | Other: Naturalistic observation<br>* Naturalistic observation<br>* Other names: Normal Aging;|
| Normal Aging<br>Normal Aging with normal cognitive function | Other: Naturalistic observation<br>* Naturalistic observation<br>* Other names: Normal Aging;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prevalence, incidence of neurocognitive disorder | Prevalence, incidence of neurocognitive disorder such as AD, MCI and other types of dementia | 5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prevalence, incidence of mood disorder | Prevalence, incidence of mood disorder such as depression, anxiaty | 5 years | 
| conversion rate | conversion rate of neurocognitive disorder from Normal Elderly | 5 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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dementia, depression, cohort study, sample bank, precision diagnosis, brain imaging