Sevoflurane and Percutaneous Coronary Intervention by Stent

Study Overview
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Brief Summary
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Increase in CK-MB after percutaneous coronary angioplasty more than 100% of baseline can represents a problem to the patients resulting in increase of morbidity and mortality. Patients submitted of coronary angioplasty procedures can release in varying degrees of creatine kinase, MB isoform (CK - MB), on the order of 30% of all angioplasty. Possibly patients who will receive sevoflurane experience a higher level of cardiac cell protection with lower incidence in the release of CK - MB values in excess of 100% baseline.

Detailed Description
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Several published clinical studies have shown the benefit of using inhaled anesthetic agents in patients undergoing coronary artery bypass graft(CABG). These benefits involve functional state of the heart and reduction damage to the organ. These events are related to intracellular phenomena that result in intracellular calcium homeostasis giving physical and functional benefits to the heart. Also disclosed is a modulation of the inflammatory response to endothelial level with resulting protective character to the coronary bed. Patients submitted of coronary angioplasty procedures can release in varying degrees of creatine kinase, MB isoform (CK - MB), on the order of 30% of all angioplasty. Even in smaller increases than 3 times baseline, a criterion that defines myocardial infarction, clinical impact can already be found. Increase in CK-MB more than 100% of baseline can represents a problem to the patients. This elevation of CK - MB is associated with various factors such as age, characteristic of the lesion, clinical status of the patient, inferring that endovascular procedures of coronary, simple or complex, have associated myocardial damage, which depending on the intensity of the damage, results in increased morbidity and mortality. BACKGROUND AND OBJECTIVES: Check for reduction in the percentage of patients that release CK -MB at levels above the 100% baseline in patients anesthetized with sevoflurane compared to the control group. Possibly patients who will receive sevoflurane experience a higher level of cardiac cell protection with lower incidence in the release of CK - MB values in excess of 100% baseline.

Official Title
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Effect of Sevoflurane on CKMB Release After PCI With Drug-eluting Stents: a Randomised Trial

Conditions
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Myocardial Infarction

Intervention / Treatment
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* Drug: sevoflurane


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Both gender. Patients with coronary artery disease candidates for coronary angioplasty stent. Cardiac catheterization on an urgent basis. Coronary angioplasty in elective and urgency. Age less than 80 years. Exclusion Criteria: Patients aged greater than or equal of 80 years. Angioplasty balloon catheter statement. Myocardial infarction with ST-segment elevation. Angioplasty in saphenous vein grafts in patients after surgical revascularization. Patient pregnant. Dialytic insufficiency renal. Patients submited a urgent cardiac catheterization but not progress with coronary angioplasty stent.

Ages Eligible for Study
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Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Sevoflurane Group<br>Sevoflurane Group called group A patients will receive sevoflurane. The patients of group A will receive facial mask properly attached to your face, inspiratory fraction of sevoflurane 3%, with therapeutic target of 1.2% expired fraction into spontaneously breathing.This exposure will during 30 min. Than, the mask will remove of the face and the patient will spontaneously breathing in ambient air during 10 min. This procedure is sufficient to induce the pre anesthetic conditioning in the group exposed to sevoflurane. After the end of this exhibition, patients will be allowed to enter the catheterization laboratory for angioplasty, no more any anesthetic agent will be administer until the end of his procedure. | Drug: sevoflurane<br>* compare effect of sevoflurane when administered before PCI<br>|
| Placebo Comparator: Control Group<br>Control Group called group B patients who will not receive sevoflurane. The patient of group B will receive facial mask properly attached to your face into spontaneously breathing.This exposure will during 30 min. Than, the mask will remove of the face and the patient will spontaneously breathing in ambient air during 10 min. After the end of this exhibition, patients will be allowed to enter the catheterization laboratory for angioplasty, no more any anesthetic agent will be administer until the end of his procedure. | Drug: sevoflurane<br>* compare effect of sevoflurane when administered before PCI<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measure level of Ck-MB in all patients |  | 24 hours after coronary intervention | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Length of stay in hospital | It will be quantified the length of hospital stay of patients who underwent coronary intervention checking if there is difference between groups | 30 days after coronary intervention | 
| Length of stay in Intensive Care Unit (UCI) | The length of stay in UCI will be quantified if patients who underwent coronary intervention are referred to this sector | 30 days after coronary intervention | 
| mortality rate |  | 1 year after coronary intervention | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Sevoflurane, Ck-MB