Hearts of Athletes

Study Overview
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Brief Summary
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The Hearts of Athletes study is being conducted to determine the heart involvement with COVID-19 in athletes. This study aims to enroll any Adult (18 years of age or greater) • Athlete is defined as NCAA Collegiate Athlete, Professional Athlete, Military, or Olympic Athlete will be eligible for the study. With COVID-19 • COVID-19 diagnosed via an RT-PCR (nasal or throat swab test) prior to enrollment Or without COVID-19 • Identified as a local Control participant (similar sport) to a participant with COVID-19, who is willing to undergo a standard cardiovascular evaluation Participants with and without COVID-19 will use their mobile devices to provide health information, like symptoms, by answering survey questions daily for 30 days. Also, participants will allow their de-identified cardiac images to be sent to the Duke Heart Center for blinded analysis. No physical risks are associated with this study. One possible risk, although minimal, is loss of confidentiality.

Official Title
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Hearts of Athletes Study: Prospective Evaluation of Athletes for Cardiac Involvement With COVID-19

Conditions
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Cardiac Involvement With COVID-19

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Any adult athlete (defined as NCAA Collegiate Athlete, Professional Athlete, or Olympic Athlete) will be eligible for the study. COVID-19 diagnosed via an RT-PCR, or history of COVID-19 antibodies at least 10 days and less than 6 months prior to consent No longer requiring quarantine per local health recommendations, prior to cardiovascular evaluation. Identification as a Control participant (similar sport) to a participant without COVID-19 willing to undergo cardiovascular evaluation Exclusion Criteria: Anyone with known cardiovascular disease - defined as known myocardial disease, valvular heart disease, or known coronary heart disease Anyone without the ability to provide informed consent Anyone with a known contraindication to cardiac magnetic resonance (metallic implant)

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 30 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Athletes with COVID-19<br> | |
| Athletes without COVID-19 (control)<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of Definite Myocarditis as measured by CMR (Cardiac Magnetic Resonance Imaging) |  | Up to 7 months | 
| Rate of Possible Myocarditis as measured by CMR (Cardiac Magnetic Resonance Imaging) |  | Up to 7 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of abnormal ECGs as measured by medical record abstraction |  | Up to 7 months | 
| Number of abnormal Troponin as measured by medical record abstraction |  | Up to 7 months | 
| Number of abnormal echocardiogram as measured by medical record abstraction |  | Up to 7 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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athletes