Temperature and Healing in Treatment of Gingival Enlargement

Study Overview
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Brief Summary
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Aim: Gingival enlargement is a common clinical condition which requires surgical approaches to alleviating these enlargement areas. The aim of this study was to investigate epithelization, gingival temperature, inflammation and pain levels in post-operative healing process in 4 different gingivectomy techniques including Er:YAG laser, Nd:YAG laser, electrosurgery and conventional gingivectomy in treatment of chronic inflammatory gingival enlargements. Material and Method: A split-mouth designed study was conducted on 37 systemically healthy patients consisting of 19 females and 18 males, who had gingival enlargement areas on the left and right of maxillary and mandibular anterior regions. Gingival crevicular fluid (GCF) samples were collected, clinical periodontal parameters and gingival temperature levels were recorded at baseline and in the postoperative period. The gingival temperature was measured during surgical procedures. Gingival temperature and epithelization levels in 3rd, 7th, 10th and 15th days; GCF levels in 15th, 30th, and 90th days and pain levels in 2nd and 8th hours and between 1st-7th days of post-operative healing process were evaluated.

Official Title
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Evaluation of Temperature and Healing in Treatment of Gingival Enlargement Using Different Gingivectomy Techniques

Conditions
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Gingival Enlargement

Intervention / Treatment
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* Procedure: Er:YAG LASER, Nd:YAG laser, elctrosurgery, conventional surgery


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: systemically healthy individuals the existence of at least 20 functioning teeth, the existence of chronic inflammatory gingival enlargement in anterior quadrants. Exclusion Criteria: pregnancy/lactation drug use, previous periodontal therapy within 6 months previous antibiotic use within 6 months, smoking the existence of attachment/bone loss. .

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: The present study was designed as a controlled clinical study with a randomized design. The study protocol was approved by the local ethical committee of Clinical Studies of Ondokuz Mayis University. The study population consisted of 37 participants (19 women, age 23.10±2.78, 18 men age 21.11±2.63).
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: group 1;<br>Er:YAG laser | Procedure: Er:YAG LASER, Nd:YAG laser, elctrosurgery, conventional surgery<br>* Er: YAG laser (Fotana AT Fidelis III, Ljubljana, Slovenia) 200 mj, 10 Hz, 2 Watt and VLP (long pulse, 1000 μs); 1.3 mm diameter, 8 mm long cylindrical, a sapphire tip was used with air cooling and water irrigation. Nd: YAG laser (Fotana AT Fidelis III, Ljubljana, Slovenia) was applied at 4 watts, 50 Hz, 300 μm microfiber tip and SP (short pulse: 180 μs) settings. Electrosurgical (Servotome Classic System, High Frequency Surgical Equipment, Satelec, France). Conventional surgical method was applied with hand instruments and gingivectomy knives.<br>|
| Other: group 2<br>Nd:YAG laser | Procedure: Er:YAG LASER, Nd:YAG laser, elctrosurgery, conventional surgery<br>* Er: YAG laser (Fotana AT Fidelis III, Ljubljana, Slovenia) 200 mj, 10 Hz, 2 Watt and VLP (long pulse, 1000 μs); 1.3 mm diameter, 8 mm long cylindrical, a sapphire tip was used with air cooling and water irrigation. Nd: YAG laser (Fotana AT Fidelis III, Ljubljana, Slovenia) was applied at 4 watts, 50 Hz, 300 μm microfiber tip and SP (short pulse: 180 μs) settings. Electrosurgical (Servotome Classic System, High Frequency Surgical Equipment, Satelec, France). Conventional surgical method was applied with hand instruments and gingivectomy knives.<br>|
| Other: group 3<br>Electrosurgery | Procedure: Er:YAG LASER, Nd:YAG laser, elctrosurgery, conventional surgery<br>* Er: YAG laser (Fotana AT Fidelis III, Ljubljana, Slovenia) 200 mj, 10 Hz, 2 Watt and VLP (long pulse, 1000 μs); 1.3 mm diameter, 8 mm long cylindrical, a sapphire tip was used with air cooling and water irrigation. Nd: YAG laser (Fotana AT Fidelis III, Ljubljana, Slovenia) was applied at 4 watts, 50 Hz, 300 μm microfiber tip and SP (short pulse: 180 μs) settings. Electrosurgical (Servotome Classic System, High Frequency Surgical Equipment, Satelec, France). Conventional surgical method was applied with hand instruments and gingivectomy knives.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Epithelization | Wound surface epithelization in the healing process was evaluated with a staining solution (Mira-2-tone, GMBH & Co., Duisburg, Germany). (O. Ozcelik et al., 2008) | Epithelization was evaluated at postoperative 7th day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Gingival temperature | The temperature measurement during the process was performed by an infrared thermometer (Optris GMBH, Manuel LS, Berlin, Germany). The device had a measurement and recording range from -35 ° C to 900 ° C, optical resolution 75: 1, thermal resolution 0.1 ° C, waveband range 8-14, USB interface and graphical software program. | The gingival temperature was measured during surgical procedures | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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gingival enlargement, Er:YAG, Nd:YAG, electrosurgery