The 3D Cohort Study (Design, Develop, Discover)

Study Overview
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Brief Summary
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The 3D Cohort Study (Design, Develop, Discover) was established to help bridge knowledge gaps about the links between various adverse exposures during pregnancy with birth outcomes and later health outcomes in children.

Detailed Description
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The main objective of the 3D study is to create a large pregnancy and birth cohort, allowing for the assessment of the effects of combined prenatal exposure on both birth outcomes and longer-term infant and child health. The specific objectives are to: Determine the effects of pre- and post-natal exposures to environmental contaminants, nutritional factors and psychosocial stress on pregnancy and neurodevelopmental outcomes; Assess the contribution of social, genetic, epigenetic, nutritional and environmental factors to the etiology and outcomes of intrauterine growth restriction (IUGR) and preterm birth; and Assess the effects of assisted reproductive technologies (ART) on indicators of epigenetic modifications, and the relationship between such epigenetic changes and infant neurodevelopmental, cardiovascular, and metabolic outcomes.

Official Title
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3D Cohort Study: The Integrated Research Network in Perinatology of Quebec and Eastern Ontario

Conditions
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Pregnancy Outcome

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Able to communicate in French or English Exclusion Criteria: Current intravenous drug use Severe illnesses or life threatening conditions Multiple gestation pregnancies

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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Female

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Intrauterine growth restriction | Birth weight smaller than 10th percentile | At delivery | 
| Preterm birth | Delivery before 37 weeks of gestation | At delivery | 
| Neurodevelopment - Bayley | Neurodevelopmental assessment of the infant. Test used : Bayley Scales of Infant and Toddler Development (BSID-III; cognitive scale and motor scale combined). This test was done on 1520 children. | When infants are 2 years old | 
| Neurodevelopment - ABAS | Neurodevelopmental assessment of the infant. Test used : Bayley Adaptive Behaviour Questionnaire (ABAS-II). This test was done on 1520 children. | When infants are 2 years old | 
| Neurodevelopment - Sensory Profile | Neurodevelopmental assessment of the infant. Test used : Sensory Profile questionnaire. This test was done on 1520 children. | When infants are 2 years old | 
| Neurodevelopment - MacArthur-Bates | Neurodevelopmental assessment of the infant. Test used : MacArthur Communicative Development Inventories (CDI; French, English, Spanish and/or Mandarin). This test was done on 1520 children. | When infants are 2 years old | 
| Neurodevelopment - M-CHAT | Neurodevelopmental assessment of the infant. Test used : Modified Checklist of Autism in Toddlers (M-CHAT). This test was done on 1520 children. | When infants are 2 years old | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Intrauterine growth restriction, Preterm birth, Birth defect, Infant growth, Neurodevelopmental outcomes