Effect of Acitretin Versus Narrowband Ultraviolet B on Neopterin Level in Psoriatic Patients .

Study Overview
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Brief Summary
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To evaluate effect of acitretin versus Narrowband UVB on serum level of neopterin in psoriatic patients.

Official Title
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Evaluation of the Effect of Acitretin Versus Narrowband Ultraviolet B on Serum Neopterin Level in Psoriatic Patients .

Conditions
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Psoriasis

Intervention / Treatment
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* Drug: Acitretin 25Mg Cap
* Radiation: Narrowband ultraviolet B


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with psoriasis diagnosed clinically Aged (15-60). Exclusion Criteria: Patient with history of skin cancer. Patient with history of photosensitivity. Pregnancy and lactation. Liver failure. Renal failure. Patient with psoriatic artheritis. Patient with allergy to product or any of its components. Patient with poorly controlled dyslipidemia. Patient receiving tetracyclines.

Ages Eligible for Study
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Minimum Age: 15 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Acitretin<br>Patients will Receive Acitretin (0.25-1 mg /kg/day )for 3months . | Drug: Acitretin 25Mg Cap<br>* Acitretin is an oral retinoid (a derivative of vitamin A) given in a dose 0.25-1 mg /kg/day for 3months in psoriatic patients<br>|
| Active Comparator: Narrowband ultraviolet B<br>Patients will receive Narrowband UVB( 3session /week ) for 3months. | Radiation: Narrowband ultraviolet B<br>* Narrowband UVB is the most common form of phototherapy used to treat psoriasis, given 2-3 sessions per week for 3 successive months<br>* Other names: Narrowband UVB;|
| Active Comparator: Combination of Narrowband ultraviolet B and Acitretin<br>Patients will receive Acitretin (0.25-1 mg /kg/day ) and Narrowband UVB( 3session /week ) for 3 months. | Drug: Acitretin 25Mg Cap<br>* Acitretin is an oral retinoid (a derivative of vitamin A) given in a dose 0.25-1 mg /kg/day for 3months in psoriatic patients<br>Radiation: Narrowband ultraviolet B<br>* Narrowband UVB is the most common form of phototherapy used to treat psoriasis, given 2-3 sessions per week for 3 successive months<br>* Other names: Narrowband UVB;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Serum Neopterin in psoriasis | Measurement of Neopterin in psoriatic patients before and after treatment with NB-UVB, Acitretin and combination of both modalities using ELISA (enzyme-linked immunosorbent assay). | 3 Months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Treatment of psoriasis | Clinical evaluation: Assessment of disease severity will be performed by using psoriasis area severity index (PASI score) before and after treatment with NB-UVB, Acitretin and combination of both modalities. | 3 Months |