Long Term Outcomes of Patients With COVID-19

Study Overview
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Brief Summary
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The investigators hypothesize that those with respiratory failure due to COVID-19 will have different burdens of mental and physical disability than those with respiratory failure who do not have COVID-19. Detecting these potential differences will lay an important foundation for treating long term sequelae of respiratory failure in these two cohorts.

Detailed Description
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The aim of this proposal to is to understand the extent and degree of physical disability, psychological sequelae, and cognitive dysfunction survivors of COVID-19 related critical illness will have upon hospital discharge, 6 months, and up to one year post discharge. These outcomes of interest will be evaluated prospectively. The investigators will perform these measures in Covid-19 patients with respiratory failure and compare them to non-Covid-19 patients with respiratory failure. The investigators also seek to determine the risk factors of these long-term complications in order to guide providers as to which patients should be screened for these deficits. Finally, the investigators will examine the association of various critical care interventions such as invasive versus noninvasive mechanical ventilation or use of sedatives and their effects on disability and cognitive dysfunction.

Official Title
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Long Term Outcomes of Patients With COVID-19

Conditions
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Critical Illness, Corona Virus Infection, Respiratory Failure, Covid-19

Intervention / Treatment
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* Other: Quality of Life
* Other: Impact Event Score
* Other: Hospital anxiety and depression scale


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: adult patients admitted to the ICU Exclusion Criteria: none

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| COVID19 positive<br>ICU patients coronavirus positive | Other: Quality of Life<br>* Physical disability assessment tool<br>* Other names: SF-36;Other: Impact Event Score<br>* Psychological Sequelae assessment tool<br>* Other names: IES-R;Other: Hospital anxiety and depression scale<br>* Psychological Sequelae assessment tool<br>|
| non-COVID19<br>ICU patients without coronavirus | Other: Quality of Life<br>* Physical disability assessment tool<br>* Other names: SF-36;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quality of Life score | SF-36 score | up to 12 months after discharge | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| cognitive dysfunction | Montreal Cognitive Assessment (MoCA) score | up to 12 months after discharge | 
| Functional Status Score | (FSS-ICU) | up to 12 months after discharge | 
| Physical Disability | MRC neuromuscular Assessment | up to 12 months after discharge | 
| Psychological Sequelae | Impact Event Score | up to 12 months after discharge | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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long term outcomes, mechanical ventilation, noninvasive ventilation