The Efficacy of REHACOP Program in Schizophrenia

Study Overview
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Brief Summary
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This study examined the efficacy of an integrative cognitive remediation program (REHACOP) to improve cognition, social cognition, clinical symptoms and functional outcome in patients with schizophrenia.

Official Title
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Implementation of REHACOP Cognitive Training Program in Schizophrenia

Conditions
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Schizophrenia

Intervention / Treatment
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* Behavioral: REHACOP
* Behavioral: Occupational activities


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: diagnostic criteria for Schizophrenia according to American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) Exclusion Criteria: evidence of alcohol or drug abuse in the last 30 days previous history of significant lack of consciousness mental retardation relevant neurological or medical condition

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Rehacop group<br>Cognitive rehabilitation | Behavioral: REHACOP<br>* REHACOP group consists of 90-minute-long sessions 3 days per week. Specifically, REHACOP group remediation consisted of: Attention unit (4 weeks) training sustained, selective, alternant and divided attention; Memory unit (3 weeks) focusing on visual and verbal learning, recall and recognizing memory; Language unit (3 weeks) including grammar, syntax, vocabulary, verbal fluency, verbal comprehension, abstract language; Executive functions unit (2 weeks) training cognitive planning, proverbs, analogies; and Social cognition unit (1 week) exercising theory of mind, social reasoning and moral dilemmas<br>|
| Active Comparator: Control group<br>Occupational activities | Behavioral: Occupational activities<br>* Occupational group activities conducted included drawing, gardening, reading the daily news and constructing using different materials (such as paper or wood).<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in functional competence after receiving cognitive remediation | functional competence was measured with San Diego UCSD Performance-Based Skills Assessment- UPSA | 4 months | 
| Change in global functioning after receiving cognitive remediation | global functioning measured with Global Assessment of Functioning (GAF) | 4 months | 
| change in verbal memory after receiving cognitive remediation | Verbal memory performance was assessed with the Hopkins Verbal Learning Test-HVLT (Brandt and Benedict 2001) | 4 months | 
| change in processing speed after receiving cognitive remediation | Processing speed was assessed with Digit Symbol subtest from Wechsler Adult Intelligence Scale-III (Wechsler 1997) | 4 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change in emotion perception after receiving cognitive remediation | emotion perception was assessed with Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT) | 4 months | 
| change in clinical symptoms after receiving cognitive remediation | Clinical symptoms was measured with Positive and Negative Syndrome Scale (PANSS) | 4 months | 
| change in social perception after receiving cognitive remediation | Social perception was assessed with the Social Featuring Recognition Test (SFRT) | 4 months | 
| change in theory of mind after receiving cognitive remediation | Theory of mind was assessed with Happe Strange Stories Test | 4 months |