Analyzing the Relationship Between Speed Propofol is Given and Low Blood Pressure

Study Overview
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Brief Summary
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The objective of this study is to evaluate the hemodynamic changes related to Propofol administration rate. We hypothesize that slow administration of IV propofol will have less hemodynamic disturbances and will require less amount of vasoactive medication for BP correction when compared to standard FDA approved administration rate.

Official Title
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Analyzing the Relationship Between Rate of Induction and Perioperative Hypotension Using Propofol

Conditions
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Hypotension on Induction

Intervention / Treatment
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* Other: Propofol slow administration


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: any patient from 18 till 80 years of age patient undergoing non-cardiac elective surgery duration of the surgery longer than one hour native/fluent English speaker patients whose staff anesthesiologist planned to use Propofol as a primary anesthetic for induction Exclusion Criteria: any patient admitted for non-elective surgery any patient undergoing cardiac surgery any patient under 18 years of age any patient older than 80 years of age any patient with history of severe heart disease (CHF with significant limitations of activity due to sever symptoms, prior heart surgery, atrial fibrillation, etc.) any patient with pre-operative hemodynamic instability (e.g. sepsis, chronic kidney disease, liver cirrhosis) who requires constant or intermittent administration of vasoactive or inotropic medication to support vital signs (BP) any patient on vasoactive or inotrop medications in early pre-operative period (within 24 hours prior to the surgery) any patient who does not speak English or not fluently any patient with cognitive impairment or mentally incapacitation any pregnant or breastfeeding females any patient whose staff anesthesiologist planned to use a primary anesthetic other than Propofol

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Group A- propofol given at FDA approved administration speed<br> | |
| Experimental: Group B- propofol given over 120 seconds<br> | Other: Propofol slow administration<br>* Propofol will be slowly administered over 120 seconds by anesthesia provider<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patients administered Propofol at a slower rate of infusion will have lower incidence of post induction hypotension than patients administered Propofol at FDA approved rate. | We will collect the patient's blood pressure intra-operatively every 5 minutes starting on induction up to one hour after induction and compare. | induction to 1 hour post induction | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patients administered Propofol at a slower rate will have less complications during the early post-op period than patients administered Propofol at FDA approved rate. | We will collect the patient's blood pressure post-operatively and length of hospital stay and compare. | immediate post-op to 30 days post operatively |