HPV Infections, Cancer of the Vulva and Therapeutical Success

Study Overview
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Brief Summary
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HPV infections may be responsible for different types of cancer in females. Primary Goal of the study was to identify the prevalence of an hpv affiliation in retrospective-prospective analysed cohort of patients who suffer from vulvar cancer and their preinvasive lesions.

Detailed Description
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HPV infections may be responsible for different types of cancer in females. Primary Goal of the study was to identify the prevalence of an hpv affiliation in retrospective-prospective analysed cohort of patients who suffer from vulvar cancer and their preinvasive lesions. After having retrospectively identified patients with vulvar cancer incl. their preinvasive lesions in the clinical registry the hpv status of the samples is prospectively analyzed using a new multiplex pcr Array. Two Groups are build: patients with hpv associated vulvar cancer and patients with non-hpv associated vulvar cancer. Then, the rate of patients who respond to radiotherapy within the Groups is analyzed by building Kaplan meier plots according to the patients survival and recurrence rate.

Official Title
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Influence of Hpv Infections on Therapeutical Outcome of Patients Suffering From Vulvar Cancer and Ist Preinvasive Lesions

Conditions
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HPV, Human Papilloma Virus

Intervention / Treatment
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* Diagnostic Test: polymerase chain reaction


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: pts. who suffer from vulvar cancer and their preinvasive lesions positive informed consent complete set of data Treatment in luebeck university Exclusion Criteria: opposite of above
Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>human papilloma Virus (hpv) associated vulvar cancer incl. preinvasive lesions | Diagnostic Test: polymerase chain reaction<br>* PCR is performed with all patients. The result (hpv positive or negative) will define the patiens Group Affiliation.<br>* Other names: EUROARRAY;|
| 2<br>non-human papilloma Virus (hpv) associated vulvar cancer incl. preinvasive lesions | Diagnostic Test: polymerase chain reaction<br>* PCR is performed with all patients. The result (hpv positive or negative) will define the patiens Group Affiliation.<br>* Other names: EUROARRAY;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| prevalence of hpv infections among pations suffering from vulvar cancer and preinvasive lesions |  | 15yrs | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| disease free survival among the groups |  | 15yrs | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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hpv prevalence, recurrence rate, survival