Prognosis Predictors for Heart Failure

Study Overview
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Brief Summary
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This study is looking for the predictors of the survival or rehospitalization of patients with heart failure with reduced ejection fraction. Participants who are discharged from an acute heart failure hospitalization are enrolled.

Detailed Description
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This study is looking for the predictors of the survival or rehospitalization of patients with heart failure with reduced ejection fraction. Participants who are discharged from an acute heart failure hospitalization are enrolled. The prognostic factors provide information about the treatment of this disease in the future. This study is a retrospective observational study. Investigators will collect data from May 2014 to July 2019 in the heart failure center of Kaohsiung Chang Gung Memorial Hospital. A follow-up is conducted at the Kaohsiung HF center until August 2020. Investigators want to know whether the risk factors such as atrial fibrillation, diabetes, nephropathy, and some biochemical indexes can be an index that predicts future survival or rehospitalization of these patients. Besides, investigators will also explore the cardiac rehabilitation can also effectively improve the survival rate of such patients.

Official Title
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Looking for Prognostic Factors That Affect the Survival of Patients With Heart Failure

Conditions
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Heart Failure, Rehabilitation, Morality, Hospitalization, Life Quality

Intervention / Treatment
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* Other: cardiac rehabilitation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: inpatient, age >= 20 years old, male or female patient with heart failure with a reduced ejection fraction and discharged alive from the hospital received heart failure disease management program Exclusion Criteria: Estimated survival time < 6 months Long-term bedridden for more than 3 months Cannot tolerance exercise test due to muscular-skeletal disorder Cannot co-operate all functional studies Ventilator dependent Terminal heart status The family reject to participate in this project

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: cardiac rehabilitation|multidisciplinary disease management program|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| all-cause mortality | Number of participants that had occurrence of the mortality which is defined as all-cause mortality | May, 2014   August 2020 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| first heart failure rehospitalization | Number of Participants That Had Occurrence of the Endpoint, Which is Defined as First Heart Failure (HF) Hospitalization | May, 2014   August 2020 | 
| Change From Baseline to Month 6 and Month 12 for the Kansas City Cardiomyopathy Questionnaire 12 (KCCQ 12) Clinical Summary Score | Change from baseline to Month 6 and month 12 for the Kansas City Cardiomyopathy Questionnaire short form (KCCQ12) clinical summary score. KCCQ12 is a 12-item, self-administered instrument that quantifies physical function, symptoms (frequency, severity and recent change), social function, self-efficacy and knowledge, and quality of life. KCCQ12 clinical summary score is a composite assessment of physical limitations and total symptom scores. Scores are transformed to a range of 0-100, in which higher scores reflect better health status. | May , 2014   August 2020 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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cardiac rehabilitation, multidisciplinary program, heart failure, mortality, renin-angiotensin-aldosterone system