Epidemiological Study of Intestinal Colonization With Staphylococcus Aureus

Study Overview
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Brief Summary
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Nasal colonization with S. aureus is a risk factor for infection with this bacterium. A methodologically well conducted study of S. aureus bacteremia showed that 80% of S. aureus bacteremia with are due to the strain isolated in the nasal level. However, as part of a study coordinated by the CHU of Saint-Etienne, less than 50% of infections in prosthetic orthopedic devices have been linked to nasal carriage . Outside of exogenous infections, intestinal colonization with S. aureus could be an alternative source of endogenous infections with the waning of orthopedic surgery. In the general population, considering that about one third of the subjects were colonized with S. aureus nasal level and 1 in 5 in the intestine However the proportion of exclusive intestinal porting is not well known . This study will analyze, among ICU patients, porting S. aureus nasal and rectal level. It will better clarify the relationship between nasal and rectal ports and the risk of developing an infection.

Detailed Description
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The adult patients hospitalized in intensive care at the University Hospital of Saint-Etienne have a multiresistant bacteria porting screening at the nose and rectum at admission and then once a week. These samples will be carried unchanged way for the study but will also be a research S Aureus

Official Title
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Epidemiological Study of Intestinal Colonization With Staphylococcus Aureus in a Cohort of Adult Patients Hospitalized in Intensive Care at the University Hospital of St Etienne.

Conditions
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Staphylococcus Aureus

Intervention / Treatment
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* Procedure: Nasal and rectal bacterial samples


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients hospitalized in intensive care and benefiting from a screening multiresistant bacteria in nasal and rectal level under routine care Exclusion Criteria: refusal of the patient's family

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Nasal and rectal samples<br>ICU patients with nasal and rectal bacterial samples for the presence of S Aureus | Procedure: Nasal and rectal bacterial samples<br>* Bacterial nasal and rectal samples at admission and one weekly for the presence of S Aureus<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| prevalence of S. aureus colonization at rectal level | The presence of a colony of S. aureus on one of the samples | 1 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| S. aureus strains similar to nasal and rectal level | S. aureus strains similar in molecular typing | 1 month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Intensive care, S Aureus