Interest of the Dermabrasion by Laser Erbium in the Treatment of the Vitiligo

Study Overview
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Brief Summary
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The treatment of vitiligo remains disappointing especially in some localization such as bony prominences and extremities. The association of UVB and topical steroids has been proven to be synergistic but the results are still insufficient in those difficult to treat areas. Promising results have been shown with the combination of laser assisted dermabrasion, topical 5FU and UVB. The investigators hypothesize that the dermabrasion of vitiligo skin followed by topical steroids should potentialized the effect of UVB and be superior to topical steroids and UVB without dermabrasion. The main objective of this study is to evaluate the usefulness of laser assisted dermabrasion combined to topical steroids and UVB phototherapy in difficult to treat areas. Patients with symmetrical non segmental vitiligo will be included in this prospective randomized monocentrer study. The investigators calculated the number of patients needed at 25. The side that will receive the dermabrasion will be centrally randomized and the opposite side will serve as control. Then on both side class 3 topical steroids will be applied daily 3 weeks on 4 for 12 weeks. UVB phototherapy will be performed twice weekly also for 12 weeks. The evaluation will be performed by two independent physician blinded to the treatment of standardized photos before and 1 month after the end of the treatment. The criteria of success will be at least 75% of repigmentation.

Conditions
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Vitiligo

Intervention / Treatment
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* Device: Group Laser = Arm A
* Drug: Bras B : The group control


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age between 18 at 85 Not segmental Vitiligo of clinical diagnosis located on bony projections or of ends Two symmetrical plates of vitiligo of more than 4 cm ² Exclusion Criteria: Pregnant women or breastfeeding. Vitiligo lesions on face and neck Personal history of skin cancer Photosensitize drugs Personal history of photodermatosis Personal history of keloids Concomitant treatment that could have an action on vitiligo (such as tacrolimus or pimecrolimus).

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Group Laser = Arm As A<br>Opposite side lesions that will receive only the treatment by topical steroids and UVB phototherapy | Device: Group Laser = Arm A<br>* Opposite side lesions that will receive only the treatment by topical steroids and UVB phototherapy<br>|
| Placebo Comparator: Bras B : the control group<br>patient to accept habitual treatment of corticoid | Drug: Bras B : The group control<br>* patient to accept habitual treatment of corticoid Opposite side lesions that will receive only the treatment by topical steroids<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Lesions that will receive the treatment by dermabrasion associate to habitual treatment of topical steroids and UVB phototherapy | Opposite side lesions that will received only the treatment by topical steroids and UVB phototherapy | 4 months |