Evaluating the Effect of Oxygentherapy on Concentration at Chronic Lung Patients

Study Overview
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Brief Summary
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The objective is to study the cognitive functions in patients with chronic obstructive lung disease (COLD) and patients with interstitial lung disease (ILD) compared to healthy controls. The cognitive functions are tested with and without oxygen therapy to clarify the effect of oxygen therapy. Driving simulations is used to test the cognitive functions. The hypothesis is that patients with chronic lung disease have decreased cognitive functions and that oxygen therapy will increase their cognitive functions.

Official Title
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Evaluating the Effect of Oxygentherapy on Concentration at Chronic Lung Patients

Conditions
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Lung Diseases, Interstitial, Pulmonary Disease, Chronic Obstructive

Intervention / Treatment
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* Other: oxygen therapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: COLD with forced expiratory volume at one second (FEV1) <50%, without long term oxygen therapy COLD with FEV1 <50%, with long term oxygen therapy ILD with diffusion capacity of lung for carbon monoxide (DLCO) < 50%, without long term oxygen therapy Exclusion Criteria: comorbidity which decreases cognitive function comorbidity which decreases concentration physical comorbidity which makes it impossible to complete the test

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: COLD without long term oxygen therapy<br>Driving in the simulator two times, one time with and one time without oxygen therapy | Other: oxygen therapy<br> <br> |
| Experimental: COLD with long term oxygen therapy<br>Driving in the simulator two times, one time with and one time without oxygen therapy | Other: oxygen therapy<br> <br> |
| Experimental: ILD without long term oxygen therapy<br>Driving in the simulator two times, one time with and one time without oxygen therapy | Other: oxygen therapy<br> <br> |
| No Intervention: Controls<br>Driving in the simulator one time without oxygen therapy | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Standard deviation from the centre of the road | Measuring how far from the centre of the road the patient has been driving in the driving simulation | During the 45 min. of driving in the simulator | 
| Number of nil responses | Measuring the number of times the patients doesn't react to the number 2 on the screen | During the 45 min. of driving in the simulator | 
| Response time | Measuring the mean amount of response time from the number 2 appears on the screen until the patient reacts | During the 45 min. of driving in the simulator | 
| Number of off-road events per hour | The number of times the car is off-road during the driving simulation | During the 45 min. of driving in the simulator |