Resource Use and Disease Course in Dementia (REDIC)

Study Overview
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Brief Summary
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This project is based on a three-year program that aims to improve the knowledge of the socioeconomic consequences of dementia in Norway. By including patients with and without dementia in four different cohorts (from nursing homes, from memory clinics, home-dwelling persons with dementia and elderly persons without dementia), the project's aim is to describe the course of dementia, the economical cost of dementia and to look into possible risk factors for dementia.

Official Title
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Resource Use and Disease Course in Dementia (REDIC)

Conditions
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Neurodegenerative Diseases, Dementia

Participation Criteria
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Eligibility Criteria
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Memory clinic sample Inclusion Criteria: All patients examined at a memory clinic with mild cognitive impairment or mild dementia Exclusion Criteria: None In-home care sample Inclusion Criteria: Persons 70 years of age or older receiving in-home care from the municipality Exclusion Criteria: None Nursing-home sample Inclusion Criteria: All persons admitted to the nursing home with an expected stay of more than four weeks. Participants should be 65 years or older, unless established dementia disease, in which case younger persons also will be included Exclusion Criteria: Life expectancy of less than six weeks Control sample Inclusion Criteria: Persons 65 years or older without any sign of dementia Exclusion Criteria: None
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Memory clinic<br>People visiting a memory clinic at Ullevål University Hospital, St Olav Hospital or Innlandet Hospital Trust (n=400). The patients will be assessed three times over a three-year follow-up. Baseline inclusion started in January 2010. The final assessments will take place in spring 2014. | |
| Nursing homes<br>People admitted to a nursing home recruited from municipalities in Hedmark, Oppland, Nord-Trøndelag and Bergen (n=1000). Baseline assessments take place when the person is admitted to the nursing home. The patients will be assessed every six months over a three-year follow-up period. The first participant was included in March 2012, and baseline inclusion will be completed in December 2013. | |
| In-home care<br>People 70 years of age or older receiving in-home care recruited from municipalities in Hedmark, Oppland, Oslo, Østfold and Buskerud (n=995). The patients will be assessed three times over a three-year follow-up period. Baseline inclusion started in April 2009 and the final assessments will take place in December 2013. | |
| People without dementia<br>People without dementia recruited from Nord-Trøndelag, Drammen and Oslo (n=400). The participants will be assessed three times over a three-year follow-up period. Baseline inclusion will take place in autumn 2012 and the last follow-up will take place in autumn 2015. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cost of dementia | The cost of dementia is assessed with the Resource Utilization in Dementia (RUD) (Wimo et al. 2009), for a period of three years for all the four cohorts. The nursing home cohort is assessed at baseline and every 6 month for three years, the other three cohorts are assessed three times over a three-year follow up period. | 3 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The course of neuropsychiatric symptoms | The course of neuropsychiatric symptoms (depression, anxiety, psychosis, aggression, apathy, and cognition, are assessed with standardized assessment Tools. The nursing home cohort is assessed at baseline and every 6 month for three years, the other three cohorts are assessed three times over a three-year follow up period. | 3 years | 
| Quality of Life in persons admitted to nursing homes | Quality of Life is assessed with standardized assessment Tools. The nursing home cohort is assessed at baseline and every 6 month for three years, the other three cohorts are assessed three times over a three-year follow up period. | 3 years | 
| Prescription of medication | Prescription of medication is recorded at baseline, and the amount of medication used is recorded throughout the study period. The nursing home cohort is assessed at baseline and every 6 month for three years, the other three cohorts are assessed three times over a three-year follow up period. | 3 years | 
| DNA polymorphism | DNA samples are collected for the nursing home cohort, and they are assessed for genetic polymorphism previous associated with dementia. The results are used as covariates in the analyses of the course of the symptoms and to look for risk factors for dementia. | At baseline | 
| Organizational factors of the nursing homes | Organizational factors of the nursing homes and variables associated with the staff of the nursing homes will be collected at baseline, and the data will be used to explore associations between nursing home characteristics and the course of the symptoms in the patients. | At baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Health Care Costs, Genetic Polymorphism