The Prevalence of a Low Ankle-Brachial Index in Acute Cerebral Ischemia.

Study Overview
=================
Brief Summary
-----------------
Aim of the study is assessment the prevalence of the low ankle-brachial index (ABI) defined less than or equal 0.9 in patients with acute cerebral ischemic event (stroke or transient ischemic attack) and determinate the correlation between ABI and internal carotid artery stenosis (ICAS) in the acute cerebral ischemic patients. The low ABI is a strong marker of generalized atherosclerosis. LEAD is a strong independent predictor for stroke.

Detailed Description
-----------------
Aim of the study is assessment the prevalence of the low ankle-brachial index (ABI) defined less than or equal 0.9 in patients with acute cerebral ischemic event (stroke or transient ischemic attack) and determinate the correlation between ABI and internal carotid artery stenosis (ICAS) in the acute cerebral ischemic patients. The ABI is a non-invasive tool useful for the diagnosis of LEAD. The low ABI is a strong marker of generalized atherosclerosis. LEAD is a strong independent predictor for stroke. Significant ICAS is prevalent among patients having LEAD. Acute ischemic stroke due to significant ICAS has poor prognosis. Patients with LEAD may be a suitable subgroup for screening for ICAS using duplex scanning. Estimating the relationship between cerebral ischemic event and the ABI value could help better guide preventive and risk reduction strategies.

Official Title
-----------------
The Prevalence of a Low Ankle-Brachial Index in Patients With Acute Cerebral Ischemic Event.

Conditions
-----------------
Ischemic Stroke

Intervention / Treatment
-----------------
* Device: Duplex scanning of carotid arteries
* Device: ABI measurement


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Acute ischemic stroke or transient ischemic attack of anterior circulation Consent of patient Exclusion Criteria: primary intracranial hemorrhage, venous sinus thrombosis, unconsciousness, intubation, inability to provide and write a consent application form.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 99 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| STROKE GROUP<br>150 patients admitted to Stroke Unit with a diagnosis of acute ischemic stroke (IS) or transient ischemic attack (TIA) | Device: Duplex scanning of carotid arteries<br>* Measurement of carotid arteries<br>Device: ABI measurement<br>* ankle brachial index (ABI) assessment<br>|
| CONTROL GROUP<br>50 individuals admitted to hospital without diagnosis of acute cerebrovascular disease; with diagnosis of dizziness, epilepsy, sclerosis multiplex. | Device: Duplex scanning of carotid arteries<br>* Measurement of carotid arteries<br>Device: ABI measurement<br>* ankle brachial index (ABI) assessment<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| ABI | Prevalence of a low ankle-brachial index (ABI) in patients with acute cerebral ischemic event | 7 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| ABI/ICAS | Correlation between ABI and internal carotid artery stenosis (ICAS) in the acute cerebral ischemic patients. | 7 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Ischemic Stroke, TIA, ABI, LEAD