Non-surgical Periodontal Treatment on Hemogram, Lipid and Glycemic Profiles in Patients With Coronariopathies

Study Overview
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Brief Summary
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Objective: The aim of this study was to examine the effects of non-surgical periodontal treatment on the hemogram, glycemic and lipid profiles in cardiopathic patients with an indication for surgical revascularization. Materials and Methods: Twenty-two patients with chronic periodontitis, over 35 years of age (mean age 59.45 years) randomly assigned into 2 groups were evaluated. Test group (n=11), received periodontal treatment before the surgical procedure, and control group (n=11), did not received periodontal treatment prior to surgery.

Official Title
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Effects of Non-surgical Periodontal Treatment on Hemogram, Lipid and Glycemic Profiles of Patients With an Indication for Surgical Coronary Revascularization

Conditions
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Periodontitis, Coronariopathy

Intervention / Treatment
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* Procedure: Periodontal treatment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Undergoing cardiovascular treatment; Eight viable teeth in the oral cavity; Four periodontal sites with periodontal probing depths ≥5mm in different teeth. Exclusion Criteria: -

Ages Eligible for Study
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Minimum Age: 35 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Periodontal treatment<br>The test group received oral hygiene instructions, supragingival and subgingival scaling and root planning using curettes and an ultrasonic appliance. | Procedure: Periodontal treatment<br> <br> |
| No Intervention: Control<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Reduction in probing depth in sites with PPD>3mm | Reduction of 11.4% in probing depth in sites with Periodontal Probing Depth>3mm | Baseline and 90 days after the initial exam | 
| Reduction in probing depth in sites with PPD>5mm | Reduction of 6.3% in probing depth in sites with Periodontal Probing Depth>5mm | Baseline and 90 days after the initial exam | 
| Reduction in probing depth in sites with CAL>3mm | Reduction of 4.6% in probing depth in sites with Clinical Attachment Level >3mm. | Baseline and 90 days after the initial exam | 
| Reduction in probing depth in sites with CAL >5mm | Reduction of 3.6% in probing depth in sites with Clinical Attachment Level >5mm. | Baseline and 90 days after the initial exam | 
| Leukocyte count | Non-significant reduction of leukocyte count in the test group. Mean difference of 74.6 m/mcL. | Baseline and 90 days after the initial exam | 
| Glucose | Glucose showed a non-significant increase in the test group. Mean difference of 24.2 mg/dL. | Baseline and 90 days after the initial exam | 
| Hemocyte | Hemocyte presented a non-significant reduction in the test group. Mean difference 0.39 m/mcL | Baseline and 90 days after initial exam | 
| Hemoglobin | Non-significant reduction in test group. Mean difference of 0.2 g/dL | Baseline and 90 days after initial exam | 
| Total Cholesterol | Significant reduction in the test group. Mean reduction of 27.4 mg/dL. | Baseline and 90 days after initial exam | 
| High density lipid | Significant reduction in test group. Mean difference of 8.2 mg/dL. | Baseline and 90 days after initial exam | 
| Low density lipid | Non-significant reduction in test group. Mean difference of 8.9 mg/dL. | Baseline and 90 days after initial exam | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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periodontal diseases, cardiovascular diseases, periodontitis treatment