Study Project Comparing the Sequelae of COVID-19 Infection in Patients Who Have and Have Not Received Ventilatory Support in Critical Care

Study Overview
=================
Brief Summary
-----------------
To assess the proportion of post-intensive care syndrome (PICS) of patients who received high flow humidified oxygen with FiO2 ≥50% for more than 48h and / or who received mechanical ventilation for more than 48h in a context of hospitalization in intensive care for COVID-19 pneumonia

Official Title
-----------------
Study Project Comparing the Sequelae of COVID-19 Infection in Patients Who Have and Have Not Received Ventilatory Support in Critical Care

Conditions
-----------------
Covid19

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: - Group 1: patients hospitalized in intensive care units for ARDS with SARS-CoV-2 Major Admitted between March 1 and May 10, 2020 in one of the sectors of the Bicêtre hospital approved for critical care proven SARS-CoV-2 infection Treated by invasive mechanical ventilation or high flow humidified oxygen with FiO2 ≥50% for more than 48 hours. Group 2: patients hospitalized outside intensive care units Major Admitted between March 1 and May 10, 2020 in an area of Bicêtre hospital having cared for patients infected with SARS-CoV-2 excluding critical care: pulmonology, internal medicine / orthopedics, infectious diseases, nephrology , acute geriatrics, neurology. Exclusion Criteria: Patients having refused the post consultation at 3 month Without social security coverage

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| patients hospitalized in intensive care units for SARS-CoV-2<br>patients hospitalized in intensive care units for SARS-CoV-2 | |
| patients hospitalized outside intensive care units<br>patients hospitalized outside intensive care units | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| post-intensive care syndrome (PICS) | To assess the proportion of post-intensive care syndrome (PICS) of patients who received high flow humidified oxygen with FiO2 ≥50% for more than 48h and / or who received mechanical ventilation for more than 48h in a context of hospitalization in intensive care for COVID-19 pneumonia. | 3 month after hospitalisation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluate the 3-month mortality of patients released alive from intensive care | Number of patient deceased | 3 month after end of hospitalisation | 
| Describe the overall state of health and the main organ sequelae of these patients | Description of the data collected | 3 month after hospitalisation | 
| functional respiratory sequelae | Compare the functional respiratory sequelae of these patients to those who were hospitalized outside of critical care for COVID-19 pneumonia requiring lower oxygen support. | 3 month after hospitalisation |