The Relationship Between Post-ERCP-choledocholithiasis and Gallbladder Status

Study Overview
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Brief Summary
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In this retrospective study, the investigators evaluate the relationship of post-ERCP-choledocholithiasis(PEC ) and the gallbladder status as a risk factor.

Detailed Description
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When patients have common bile duct(CBD) stones, ERCP is widely used for stone extraction instead of clinical operation. ERCP has many advantages like less injury or faster recovery. However, according to literature, ERCP will has a mostly 10% possibility to get an acute purulent cholecystitis, which often requires emergency intervention, therefore, it is necessary to know if the gallbladder status(chronic disease) is one of the important risk factors of PEC like the gallbladder wall thickness, chronic cholecystitis, polyps,crudely or calculus. .

Official Title
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Does the Gallbladder Status Influence the Occurence of Post-Endoscopic Retrograde Choledochopancreatography(ERCP) -Choledocholithiasis

Conditions
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Cholecystitis

Intervention / Treatment
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* Procedure: ERCP


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Routine ERCP for CBD stone patients with gallbladder in situ Exclusion Criteria: Unwillingness or inability to consent for the study Unstable vital signs Coagulation dysfunction (INR>1.5) and low peripheral blood platelet count (<50×10 ^9 / L) or using anti-coagulation drugs Any Prior surgery for CBD including ERCP Preoperative coexistent diseases: acute pancreatitis, GI tract hemorrhage, severe liver disease (such as decompensated liver cirrhosis, liver failure and so on), septic shock Biliary- duodenal fistula confirmed during ERCP Pregnant women or breastfeeding

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: ERCP|Routine ERCP for CBD stone with the gallbladder in situ, the chronic gallbladder status was defined as gallbladder wall thickness≥4mm, chronic cholecystitis, polyps,crudely or calculus .|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of Acute PEC(post-ERCP-cholecystitis ) | When the PEC occurs, the temperature should be more than 38 celsius degree, right upper abdominal pain, the total amount of the White Blood Cell (WBC) is above normal for the patients who with the gallbladder wall thickness under ultrasound examination. | 1 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of Participants with Pancreatitis | Typical abdominal pain, with the level of serum amylase increasing at least 3 times of the normal range within 24 hours after ERCP. | 1 month | 
| Number of Participants with Cholangitis | Temperature should be more than 38 celsius degree, chills, with right upper abdominal pain, blood routine showing the total amount of the White Blood Cell (WBC), and the amount of polymorphonuclear neutrophil(PMN) are above normal | 1 month | 
| Number of Participants with Perforation | Typical abdominal pain,abdominal muscle tension, and there are also radiographic evidence suggesting | 1 month | 
| Number of Participants with bile duct stents | If it is necessary to get the patients drainage, Number of Participants with stents or endoscopic nasobiliary drainage (ENBD) should be recorded | 1 month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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ERCP, Acute purulent cholecystitis, Bile duct stone, PEC(post-ERCP-choledocholithiasis)