Comparison of Conservative and Endovascular Treatment for Spontaneously Isolated Superior Mesenteric Artery Dissection

Study Overview
=================
Brief Summary
-----------------
Spontaneous isolated superior mesenteric artery dissection(SISMAD) is an increasingly diagnosed disease. However, prospective, multicenter studies that can provide evidence to support clinical decisions are very limited. This study aims to compare the therapeutic efficacy of conservative and endovascular treatment for SISMAD.

Official Title
-----------------
Comparison of Conservative and Endovascular Treatment for Spontaneously Isolated Superior Mesenteric Artery Dissection: A Real-world, Multicenter, Observational Study

Conditions
-----------------
Spontaneous Isolated Superior Mesenteric Artery Dissection

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Aged 18 and above; Isolated superior mesenteric artery dissection with clear symptoms or history and confirmed by CTA Signed informed consent forms, willing to receive treatments Exclusion Criteria: Symptoms are severe and patients need exploratory laparotomy; Patients with aortic dissection, iliac artery dissection, or autoimmune vasculitis; Patients with mental illness cannot cooperate subjectively; Patients who are allergic to contrast agents, or contraindicated to conservative treatment drugs, and cannot be treated with drugs; Pregnancy and breastfeeding women, or patients who have recent birth plans; Patients who are participating in other clinical projects; Patients are not suitable to participate in this study.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Endovascular treatment Group<br>Patients receiving endovascular treatments | |
| Conservative treatment Group<br>Patients receiving conservative treatments, including blood pressure control, bowel rest, antithrombotic therapy, nutrition treatment and pain management. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality | Mortality during follow-up period | up to 5 years | 
| Rate of symptom relief | Rate of symptom relief during follow-up period | up to 5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Reintervention rate | Reintervention related to SISMAD after treatments during follow-up period | Follow-up period（ 5 years） | 
| Recurrence rate | SISMAD Recurrence after treatments during follow-up period | Follow-up period（5 years） | 
| Disease-related complications | Disease-related complications after treatments during follow-up period | Follow-up period（5 years） | 
| Complete remodeling rate of superior mesenteric artery dissection | Complete remodeling rate of superior mesenteric artery dissection after receiving different treatments | Follow-up period（5 years） |