Evaluation of the Quality of Life in Patients Referred for Transjugular Intrahepatic Portosystemic Shunt

Study Overview
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Brief Summary
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Patient with Advanced Chronic Liver Disease often present portal hypertension which may lead to bleading or ascites. One of the treatment of portal hypertension in these patients is the placement of a Transjugular Intrahepatic Portosystemic Shunt (TIPS). The indications for placing TIPS take on various clinical presentations, the most classic being digestive haemorrhage by rupture of oesophageal and/or gastric varices and refractory ascites. TIPS placement involves changes in haemodynamics and liver function that may alter the patients' condition and quality of life. Very few articles have evaluated the quality of life of these patients and when quality of life is evaluated it is mostly with not adapted or not validated scales. The main objective of this study is to evaluate the quality of life of patients who have undergone TIPS using a validated and standardised quality of life questionnaire (the SF-36 questionnaire).

Official Title
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Evaluation of the Quality of Life in Patients Referred for Transjugular Intrahepatic Portosystemic Shunt (TIPS) - Pilot Observational Cross-sectional Study

Conditions
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Chronic Liver Disease

Intervention / Treatment
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* Behavioral: Questionnaire


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age ≥ 18 years Patients referred to the TIPS service between January 2012 and October 2020 at the University Hospitals of Strasbourg, with a follow-up period of at least 1 month Subjects who have not expressed any opposition to the use of their medical data for research purposes For subjects invited to fill in the questionnaires: subject having expressed his/her agreement with the use of his/her medical data in the framework of the current study Exclusion Criteria: Diseased patient Liver transplant patient following TIPS Pregnancy Patient in a vulnerable situation Patient under court protection, guardianship or trusteeship Difficulties in understanding the questionnaire Impossible to give the subject informed information (subject in an emergency situation, difficulties in understanding the subject, etc.) Subject under legal protection

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: Questionnaire|Quality of Life assessed with the SF-36 questionnaire|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mental component of quality of Life of the | Assessment of the mental component of quality of life by a generic questionnaire (SF-36), | 45 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Chronic liver disease, TIPS, Quality of life