The Association With Peptic Ulcer Disease and Hepatic Vein Pressure Gradient

Study Overview
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Brief Summary
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The aim of this study is to assess the role of portal hypertension of peptic ulcer disease in liver cirrhosis and chronic hepatitis.

Detailed Description
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Retrospective case-control study Investigators will analyze the medical records of hepatic vein pressure gradient (HVPG) and esophagogastroduodenoscopy (EGD) cases who had liver cirrhosis (LC) or chronic hepatitis in a single tertiary hospital (Chuncheon Sacred Heart hospital, Korea) within 2008 2012. Portal hypertension is assessed using HVPG measurement via transjugular approach. Peptic ulcer is evaluated through EGD within 3 months of HVPG measurement The association of Peptic ulcer with LC, chronic hepatitis and total population (LC or chronic hepatitis) will be assessed by univariate and multivariate analysis There is no specific time frame, because this study is retrospective observational study, however EGD data is enrolled if it was done within 3 month from HVPG measurement.

Official Title
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Retrospective Observational Study of Impact of Portal Hypertension for the Peptic Ulcer in Liver Cirrhosis and Chronic Hepatitis

Conditions
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Cirrhosis, Chronic Liver Disease

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: The patients who underwent hepatic vein pressure gradient (HVPG) measurement and esophagogastroduodenoscopy (EGD) and also had LC or chronic hepatitis Exclusion Criteria: The patients who have missing or incomplete HVPG or EGD data The patients who underwent gastrectomy The patients who have systemic malignancy

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with chronic hepatitis<br>Patients with chronic hepatitis, who experienced HVPG measurement via transjugular approach and EGD within 3 months of HVPG measurement | |
| Patients with liver cirrhosis<br>Patients with liver cirrhosis, who experienced HVPG measurement via transjugular approach and EGD within 3 months of HVPG measurement | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The Association of HVPG and PUD in Patients With Liver Cirrhosis | The association of hepatic vein pressure gradient that reflects portal hypertension and peptic ulcer disease in patients with liver cirrhosis was assessed statistically. (NO specific time frame, only confined to 2009 to 2012, when the HVPG measurement was done). The Mann-Whitney test was used to evaluate the association between PUD or not and HVPG degree, by SPSS software. | Retrospective case-control study (from 2009 to 2012, up to 3 years) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The Association Between PUD and HVPG in Patients With Chronic Hepatitis |  | Retrospective case-control study (from 2009 to 2012, up to 3 years) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Peptic ulcer, Liver cirrhosis, Portal hypertension