Fructooligosaccharide and Calcium Absorption in Adolescent Girls

Study Overview
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Brief Summary
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Fructooligosaccharides (FOS) are believed to have positive effects on calcium absorption and bone accrual during growth. This study aims to see whether the addition of fiber in the form of FOS to a calcium-containing beverage will increase calcium absorption. During two clinical visits, participants will receive a beverage containing a small amount of calcium, supplemented with either no dietary fiber or a small amount of fiber. Height, weight, bone density and geometry, calcium absorption, and physical fitness will be measured. The effects of this fiber intervention may provide support for improving bone health with minimal fiber supplementation.

Official Title
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Fructooligosaccharide and Calcium Absorption in Adolescent Girls

Conditions
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Osteoporosis

Intervention / Treatment
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* Dietary Supplement: Fructooligosaccharide


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Female Calcium intake of 900-1300 mg/d Generally healthy Exclusion Criteria: Male BMI > 90th percentile for age Takes medication that influences calcium metabolism Any disorder of calcium or bone homeostasis (hypercalcemia, Paget's Disease) Smoking, illegal drug consumption Any gastrointestinal disease (Crohn's Disease, Celiac Disease, Inflammatory Bowel Disease)

Ages Eligible for Study
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Minimum Age: 10 Years
Maximum Age: 12 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: No Fructooligosaccharide<br>0 g fructooligosaccharide added to calcium-containing beverage | Dietary Supplement: Fructooligosaccharide<br>* Zero or 3 g of a fructooligosaccharide will be administered in a beverage containing 300 mg total calcium as well as 15 mg 44Ca (calcium carbonate). Participants will be given one of the above beverages in addition to intravenously receiving 5 mg 43Ca (calcium chloride)in 10 ml saline.<br>* Other names: Fiber and Calcium;|
| Active Comparator: 3 g Fructooligosaccharide<br>3 g fructooligosaccharide added to calcium-containing beverage | Dietary Supplement: Fructooligosaccharide<br>* Zero or 3 g of a fructooligosaccharide will be administered in a beverage containing 300 mg total calcium as well as 15 mg 44Ca (calcium carbonate). Participants will be given one of the above beverages in addition to intravenously receiving 5 mg 43Ca (calcium chloride)in 10 ml saline.<br>* Other names: Fiber and Calcium;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fractional Calcium Absorption |  | 24 h urine and 3 h blood | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Bone density and geometry measured with peripheral quantitative computed tomography (pQCT) |  | Initial visit | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Calcium, Bone and Bones, Girls, Bone Mineralization, Fiber, Fructooligosaccharide, Female, Healthy, Adolescents