Influence of Adipocytokines in Osteoarthritis

Study Overview
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Brief Summary
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Adipocytokines play an important role in joint inflammation in patients with knee osteoarthritis as measured by ultrasound and high sensitivity protein-C reactive. Adipocytokines could be the link between osteoarthritis and cardiovascular risk factors more prevalent in these patients.

Official Title
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Adipocytokines Influence on Clinical and Ultrasonographic Inflammatory Activity in Patients With Knee Osteoarthritis

Conditions
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Osteoarthritis, Knee, Endocrine System Diseases, Cardiovascular Risk Factors

Intervention / Treatment
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* Other: Blood analyse, arthrocentesis, ultrasound examination


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients over 50 years old with symptomatic knee osteoarthritis. Exclusion Criteria: Patients with secondary osteoarthritis of the knee Any other rheumatologic condition.

Ages Eligible for Study
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Minimum Age: 50 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Inflammatory knee osteoarthritis<br>One group of patients with inflammatory condition in physical evaluation. We will make a blood analyse and arthrocentesis when synovial fluid were found in ultrasound examination. Ultrasound of affected knee and carotid artery will be performed. | Other: Blood analyse, arthrocentesis, ultrasound examination<br> <br> |
| Non-inflammatory knee osteoarthritis<br>Patients with no inflammatory condition in physical examination. We will make a blood analyse and arthrocentesis when synovial fluid were found in ultrasound examination. Ultrasound of affected knee and carotid artery will be performed. | Other: Blood analyse, arthrocentesis, ultrasound examination<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| adipocytokine level | We will determine the adipocytokine level at the end of inclusion period between 12-18 months | 18 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ultrasound inflammatory exploration of the knee | we evaluate the presence of synovial fluid with ultrasound evaluation in the visit of the patient. Ultrasound evaluation will be performed by two Rheumatologists. | 18 months | 
| Ultrasound of carotid artery | We will evaluate patients with ultrasound exploration in order to describe the presence of atheromatous disease in the visit of the patient | 18 months | 
| Cardiovascular risk factors | We evaluate the prevalence of cardiovascular risk factors in the symptomatic knee osteoarthritis patients, and the relationship with adipocytokines. We will evaluate blood analyse levels of cholesterol, glycemia. | 18months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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adipocytokines, osteoarthritis, cardiovascular risk