Immunohistochemical Study of Chordomas to Improve Their Diagnosis and Prognosis Care

Study Overview
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Brief Summary
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Chordomas are very rare malignant tumors, chemo-resistant with high propensity for recurrence. The role of immunotherapy in these patients remains largely unexplored while PD-L1 and CD8 status in the micro-environment of chordomas is basically not known. Similarly, this tumor often poses diagnostic difficulties due to its resemblance with metastasis or chondrosarcoma, thus, it would be useful to know the expression status of factors used during the work-up of metastatic or mesenchymal tumors, like CDX2, INSM1 and FOXA1, which remains unknown for chordomas. Thus, the aim of the study is to explore PD-L1, CD8, CDX2, INSM1 and FOXA1 expression in a series of chordomas and compare it with clinico-pathological and prognostic features.

Detailed Description
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Retrospective, non-interventional study. A series of chordomas will be analyzed for detailed histologic features and for various immunohistochemical factors and results will be compared with clinical factors, like overall and disease-free survival.

Official Title
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Immunohistochemical Study of Chordomas to Improve Their Diagnosis and Prognosis Care

Conditions
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Chordoma

Intervention / Treatment
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* Other: Analysis Immunohistochemical


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients diagnosed with chordoma Sufficient histological material available Tumor expression of brachyury Exclusion Criteria: - Insufficient histological material
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Chordoma<br>Patients diagnosed with chordoma | Other: Analysis Immunohistochemical<br>* Analysis of histological material for immunohistochemical study. To explore PD-L1, CD8, CDX2, INSM1 and FOXA1 expression<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Expression of PD-L1 | measured by immunohistochemical method | Baseline | 
| Expression of CD8 | measured by immunohistochemical method | Baseline | 
| Expression of CDX2 | measured by immunohistochemical method | Baseline | 
| Expression of INSM1 | measured by immunohistochemical method | Baseline | 
| Expression of FOXA1 | measured by immunohistochemical method | Baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Histological type of tumor | data collected in personal health records. | Baseline | 
| Tumor location | data collected in personal health records. | Baseline | 
| survival of patients after diagnosis with or without progression | data collected in personal health records. | Baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Immunohistochemical, PD-L1, CD8, CDX2, INSM1, FOXA1