Calanus Oil Supplementation and Maximal Oxygen Uptake

Study Overview
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Brief Summary
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Copepod oil is extracted from the marine copepod Calanus finmarchicus, the dominant plankton species in the marine food web in the Norwegian Sea. Copepods constitute the largest renewable and harvestable resource in the Norwegian Sea and adjacent waters, and it is now developed knowledge and technology for sustainable harvesting of this new resource. The purpose of this study is to investigate whether Calanus copepod oil supplementation has an equivalent effect on maximal oxygen uptake in humans to that seen in experimental studies in mice.

Official Title
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Effect of Copepod Oil Supplementation (Calanus Finmarchicus) on Endurance and VO2max in Healthy Obese Subjects

Conditions
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Healthy

Intervention / Treatment
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* Dietary Supplement: Calanus oil
* Dietary Supplement: placebo dietary oil


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: in good health Body mass index (BMI) between 18,5 and 29,9 Exclusion Criteria: Medical condition limiting VO2max (COPD or asthma). diagnosed coronary artery disease Any other significant medical condition medication effecting exercise capacity (e.i. betablockers) Pregnancy Participation in other clinical trials Shellfish allergies Systolic blood pressure > 170 mmHG, or diastolic BP > 105 mmHG. contraindications for maximal exercise testing

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Calanus oil<br>4 capsules of 500 mg Calanus oil once every day | Dietary Supplement: Calanus oil<br> <br> |
| Placebo Comparator: Placebo<br>4 capsules of 500 mg dietary oil once every day | Dietary Supplement: placebo dietary oil<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| maximal oxygen uptake (VO2max) | Measured with indirect calorimetry at a treadmill (running/walking) with gradually increasing work load until exhaustion. After 10-15 min with warmup at 70% of maximal heart rate, work load will be increased every 1-2 minute and the changes maximal oxygen uptake (VO2) will be recorded automatically. | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Body composition (InBody, Japan) |  | 6 months | 
| Self-reported physical activity | assessed with International Physical Activity Questionnaire (IPAQ) short version | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Biological Products/therapeutic use, Copepoda, Dietary Supplements, Fish Oils, Fatty Acids, Omega-3, Oxygen Consumption, Calanus, Maximal oxygen uptake, Zooplankton