Hybrid Intraprocedural Imaging Based on 2 Different Imaging Methods

Study Overview
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Brief Summary
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The investigators will check the feasibility of an intraprocedural vitality diagnostics and the identification of an indication for Percutaneous transluminal coronary angioplasty (PTCA).

Detailed Description
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After myocard vitality diagnostics with MRI patients will underwent additionally an stress echocardiography within the exploration. By this ultrasound we will measure the LV mass and the ejection fraction per apical 2-, 3- and 4-chamber view. In addition a 2D-strain-analysis will be done to measure the systolic and diastolic strain and also the circumferential and radial strain rate parameter (by depicting three parasternal short axis views in the basal, mid-ventricular and apical plane). These measurements will be compared with the studies-conditioned MRI-finding (as reference) to find the optimal strain-parameter and the optimal cut-off-data for an intraprocedural vitality diagnostics of the single layers (endocardial, myocardial, and epicardial) for this patient group. The data upraised through this are compared off-line to the MRI findings.

Official Title
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Hybrid Intraprocedural Imaging From 2D-Strain-echocardiography and X-ray Based Biplane Coronary Angiography for Guiding Interventional Revascularization Therapy

Conditions
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Angina Pectoris, Left Ventricular Wall Motion Abnormalities

Intervention / Treatment
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* Procedure: 2D-strain echo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: left ventricular wall motion abnormalities existent myocardial vitality MRI exploration reduced LV-function steady angina pectoris patients which are legally competent and which are mentally able to understand the study staff patients give their written consent Exclusion Criteria: pregnancy or lactation acute or instable angina pectoris acute myocardial infraction in the last 3 month

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 2D-strain echo<br>After myocard vitality diagnostics with MRI follows a stress echocardiography to determine the LV volumes and EF. The received Data are compare with the MRI-Data(reference)to identify the ideal strain-parameters and Cut-Off-Result for an intraprocedural vitality diagnostic of the different films (endocardial, myocardial and epicardial). | Procedure: 2D-strain echo<br>* 2D-strain-analysis with elevation of the radial and circumferential strain and strain rate parameter(systolic and diastolic)occurs through the echocardiography. Comparison of the echocardiography and the MRI-vitality data, calculation of a cut out of vision value of a vitality diagnosis with the help of 2D-strain-analysis.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cut-Off-Value of vital myocardial tissue | It will be determine cutt-off-value of vital myocardial tissue in comparison to MRI myocardial vitality findings. | time during hospitalization | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| feasibility and safety of echocardiography during catheter investigations | it will be analyzed if it is logistically possible to perform echo-test during the actual catheter investigations (feasibility) and if the patient will be exposed to any safety risk for logistic or sterility reasons. | time during hospitalization and 1 months afterwards | 
| Determination of Strain-Parameter for identification of vital myocardial tissue | It will be determitated optimal Strain-Parameter(circumferential, systolic or diastolic)for identification of vital myocardial tissue | time during hospitalization | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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coronary stenosis, Angina pectoris, left ventricular wall motion abnormalities