Comparison of Efficacy Of Probiotic Toothpaste and Chlorhexidine Mouthwash To Reduce S.Mutans

Study Overview
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Brief Summary
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Orthodontic appliance causes increase in plaque accumulation, especially around brackets, wires and attachments. Advances in orthodontics in recent time have led to improved quality of appliance and treatment procedures ultimately resulting in improvised standard of patient care. These bacteria metabolize different kind of carbohydrates accumulated around orthodontic appliances and create acidic environment in the oral cavity leading to enamel demineralization around the brackets and white spot lesions. This study was carried out to evaluate and compare the efficacy of probiotic toothpaste and chlorhexidine mouthwash in patients undergoing orthodontic treatment with individuals who are not using them.

Detailed Description
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INTRODUCTION - When the basic oral hygiene is poor, orthodontic appliances create areas where plaque gets accumulated, especially around brackets, bands, wires, and other attachments; this facilitates the development of white spot lesions. Probiotics act by competitively inhibiting the pathogenic bacteria because they have greater adhesion to the tissues while Chlorhexidine is often used as an active ingredient in mouthwash designed to reduce dental plaque around orthodontic appliances. AIM & OBJECTIVE - The objectives of the study is to evaluate and compare the effects of the topical application of probiotic toothpaste and chlorhexidine mouthwash on the Streptococcus Mutans levels in the plaque of orthodontic patients hence improving the oral micro-flora of oral cavity by competitive inhibition of Streptococcus Mutans in plaque present around brackets. MATERIAL & METHOD - The study consists of thirty randomly selected orthodontic patients undergoing fixed appliance treatment. The patients were divided into three groups - Control Group (Group 1), Probiotic Toothpaste Group (Group 2) & Chlorhexidine Mouthwash Group (Group 3). Samples were collected at two times interval: before the study began (Phase 1) and after thirty days (Phase 2).

Official Title
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Comparison of Efficacy Of Probiotic Toothpaste and Chlorhexidine Mouthwash To Reduce Streptococcus Mutans in Plaque Around Orthodontic Brackets

Conditions
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White Spot Lesion of Tooth, Long Term Adverse Effects, Caries, Dental, Orthodontic Appliance Complication

Intervention / Treatment
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* Drug: Probiotic Toothpaste
* Drug: Dr. Reddy's Clohex
* Other: Control Group


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Orthodontic Treatment With The Straight Wire Appliance (MBT, 0.022-in Slot; 3M Unitek, Monro- Via, Calif), Permanent Dentition (Excluding Third Molars) Good General Health (No Significant Medical History Or Drug Use During The Last Month) No Anti-inflammatory Or Antibiotic Medications Taken In The Month Before The Study No Chewing Gum Or, Mouthwash Used In The Last Week And During The Study Habit Of Brushing Twice Daily With Fluoride Toothpaste Exclusion Criteria: -Patient with poor periodontal condition Patient with known medical condition e.g. Subacute bacterial, endocarditis , diabetes, valvular disease ,anaemia etc

Ages Eligible for Study
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Minimum Age: 15 Years
Maximum Age: 30 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Control Group<br>They were not given probiotic toothpaste or chlorhexidine mouthwash | Other: Control Group<br>* No Probiotic toothpaste & Chlorhexidine Mouthwash<br>|
| Experimental: Probiotic Group<br>Patients were asked to brush twice daily with given G.D Probiotic Toothpaste and were asked not to eat or drink anything for half-an-hour. | Drug: Probiotic Toothpaste<br>* G.D Probiotic Toothpaste bacteriocin Lactic Acid Bacteria<br>* Other names: G.D Probiotic Toothpaste;|
| Experimental: Chlorhexidine Mouthwash Group<br>Patients were asked to rinse daily with Dr. Reddy's Clohex chlorhexidine mouthwash of 10ml without dilution for three times a day after meals (Breakfast, Lunch Dinner) for 3-4 minutes and were asked not to eat or drink anything for half-an-hour. | Drug: Dr. Reddy's Clohex<br>* 0.20% Chlorhexidine Mouthwash<br>* Other names: Chlorhexidine Mouthwash;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Control Group/Probiotic Toothpaste/Chlorhexidine Mouthwash | Probiotic Toothpaste & Chlorhexidine Mouthwash Reduced S.mutans when compared to Control Group | 1 Month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Chlorhexidine, White Spot Lesion, Probiotics, Streptococcus Mutans, Fixed Orthodontic Treatment