Interoception in Anorexia Nervosa

Study Overview
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Brief Summary
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Anorexia nervosa is a serious psychiatric illness whose causes remain poorly understood, and which remains difficult to treat to this day. Many clinical manifestations of this disease can have their origin in abnormalities in the perception of signals coming from inside the body, but this remains to be demonstrated. In recent years, research in healthy subjects has shown how the brain constantly perceives the viscera (heart, lungs, stomach). The examiners will use these new, objective and validated methods to explore how the brain processes information from the viscera (interoception) in anorexic patients. In practice, they will quantify the coupling between the cardiac cycle and involuntary eye movements, as well as between the respiratory cycle and voluntary actions such as pressing a button. Finally, by simultaneously recording the electrical activity of the brain, and that of the stomach, the examiners will measure the coupling between the brain and the stomach. All these measurements, which will be compared between a population of patients and healthy subjects, will make it possible to determine whether anorexic patients have an alteration in the perception of their internal body signals and whether this damage affects several organs.

Official Title
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Interoception in Anorexia Nervosa

Conditions
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Anorexia, Anorexia Nervosa, Electrocardiogram, EEG

Intervention / Treatment
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* Other: Clinical and experimental session


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria - AN groups: Females 6 to 25 years old Diagnostic of AN according to DSM-5 criteria No past or current psychotic disorders No current substance abuse or dependence (excluding tobacco). No current psychiatric medication Inclusion Criteria - control groups: Females Age : matched for the AN group No present or past eating disorders No past or current psychotic disorders No current substance abuse or dependence. No current psychiatric medication Exclusion Criteria for both groups: age below 16 years and above 25 years, Past or current psychotic disorders, Current substance abuse or dependence (excluding tobacco) Opposition to participation has been expressed. In addition, for the control group, Subjects with present or past eating disorders or current mental disorders will be excluded.

Ages Eligible for Study
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Minimum Age: 16 Years
Maximum Age: 25 Years

Sexes Eligible for Study
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Female

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Control<br>Females Age : matched for the AN group No present or past eating disorders No past or current psychotic disorders No current substance abuse or dependence. No current psychiatric medication | Other: Clinical and experimental session<br>* Psychologic profile with standardized interview and scales (see below for details: SCID, BDI, STAI, BPQ, EDE Q, Pictorial Body Image Scale (PBIS) and EDI). Measure the stomach-brain synchrony during EEG/EGG resting state, the distribution of voluntary actions across the respiratory phase, and the distribution of saccadic eye movements across the cardiac-cycle.<br>|
| AN group<br>Females 16 years ≤ Age ≤ 25 years Diagnostic of AN according to DSM-5 criteria No past or current psychotic disorders No current substance abuse or dependence (excluding tobacco). No current psychiatric medication | Other: Clinical and experimental session<br>* Psychologic profile with standardized interview and scales (see below for details: SCID, BDI, STAI, BPQ, EDE Q, Pictorial Body Image Scale (PBIS) and EDI). Measure the stomach-brain synchrony during EEG/EGG resting state, the distribution of voluntary actions across the respiratory phase, and the distribution of saccadic eye movements across the cardiac-cycle.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| measure brain-stomach interactions using phase-amplitude coupling between the gastric phase and the amplitude of the cortical alpha rhythm. | Examiners will directly measure brain-stomach interactions using phase-amplitude coupling between the gastric phase and the amplitude of the cortical alpha rhythm. | Experimental session - 10 days maximum after inclusion |