Analysis of Body Composition in Relation to Outcome After Surgery in a Cohort of Patients With Esophageal Cancer

Study Overview
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Brief Summary
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The occurrence of dysphagia is a well-known early feature of esophageal cancer that may reduce caloric intake and thus cause weight loss. Sarcopenia is considered to be a consequence of such involuntary nutritional restriction. The prevalence of sarcopenia in patients with esophageal cancer before and after surgery is not well known and its possible consequences have been debated. Aim: The aim of this study was to prospectively explore body composition and function in a cohort of patients with esophageal cancer before and after surgery with curative intent. In particular, to investigate the prevalence and development of sarcopenia and body composition as a consequence to surgery for esophageal cancer and the possible relation to morbidity, length of stay and quality of life (QoL). Methods: In a cohort of 76 patients who had esophageal- or cardia-cancer and were planned for surgery with a curative intent, data on body-composition measured with bioimpedance, working capacity (cardiac stress test), grip strength and QoL (European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaires (QLQ)-C30 version 3.0) were prospectively collected. Data regarding dysphagia was derived from an esophagus related quality of life form (EORTC QLQ-OES18). Data on tumour stage and type, complications, length of stay and preoperative weight loss were collected from medical charts.

Official Title
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Analysis of Sarcopenia and Body Composition in Relation to Outcome in a Cohort of Patients With Esophageal Cancer or Cancer of the Gastroesophageal Junction Before and After Surgery With Curative Intent

Conditions
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Cancer of Esophagus, Gastric Cancer

Intervention / Treatment
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* Procedure: Resection of the esophagus and the gastroesophageal junction


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Cancer of the gastro-esophageal junction or the esophagus. Planned for curative surgery. Informed consent Exclusion Criteria: Not fulfilling the above. Patient declined participation.
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Resection of the esophagus and the gastroesophageal junction|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in Body composition after surgery for esophageal cancer with curative intent. | Body mass index (BMI) kg/m2 | Three months | 
| Changes in Body composition after surgery for esophageal cancer with curative intent | Weight kg | Three months | 
| Changes in Body composition after surgery for esophageal cancer with curative intent. | Fat free mass (FFM) kg; | Three months | 
| Changes in Body composition after surgery for esophageal cancer with curative intent. | Fat mass (FM) kg; | Three months | 
| Changes in Body composition after surgery for esophageal cancer with curative intent. | Lean tissue mass (LTM) kg; | Three months | 
| Changes in Body composition after surgery for esophageal cancer with curative intent. | Total body water (TBW) l; | Three months | 
| Changes in Body composition after surgery for esophageal cancer with curative intent. | Intra cellular water (ICW) l; | Three months | 
| Changes in Body composition after surgery for esophageal cancer with curative intent. | Extra cellular water (ECW) l | Three months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in QoL (linear scale 0-100) |  | From surgery up to three months | 
| Changes in dysphagia (linear scale 0-100) |  | From surgery up to three months | 
| Length of stay (days) |  | From surgery up to three months | 
| Complications after surgery (Clavien-Dindo scale 0-5) |  | From surgery up to three months | 
| Mortality |  | Length of survival after surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Body composition, sarcopenia, Dysphagia, Surgery, Quality of Life, Morbidity