Factors Associated With Mortality, Morbidity and Prognosis in Dementia Patients

Study Overview
=================
Brief Summary
-----------------
Dementia; It is a chronic syndrome characterized by a general and progressive deterioration in cognition, including memory, orientation, language, and comprehension. The prognosis of this progressive and neurodegenerative disease after diagnosis may differ between individuals. In its broadest sense, the prognosis after a diagnosis of dementia; can be defined by shortening of life span, high level of cognitive and functional loss, decrease in quality of life and increased need for care. However, the prognosis of different types of dementia is highly variable. Because it is the most common type of dementia, studies are usually on Alzheimer's disease. It constitutes 50-75% of total dementia cases. Vascular dementia is the second most common cause of dementia and accounts for approximately 15% of dementia cases. Dementia with Lewy bodies constitutes 10-20% of the total dementia patients and ranks second among degenerative dementia types. Frontotemporal dementia, which mimics psychiatric disorders and has prominent behavioural problems, and Parkinson's disease-associated dementia, which is characterized by cognitive impairment that can be added to the existing picture in Parkinson's patients, are also counted among other types of dementia. Prognosis-related data on dementia types other than Alzheimer's disease are limited in the literature. Determining the prognosis is important to support patients, anticipate long-term health problems, plan physician and healthcare provision, and support patients with dementia.In view of the lack of sufficient data on dementia types other than Alzheimer's disease, it is aimed to contribute to the literature on this subject and to determine the factors that may affect prognosis, morbidity and mortality in patients belonging to all dementia types.

Official Title
-----------------
Factors Associated With Mortality, Morbidity and Prognosis in Dementia Patients

Conditions
-----------------
Dementia, Dementia, Vascular, Dementia With Lewy Bodies, Dementia of Alzheimer Type, Dementia Frontal, Dementia, Mixed

Intervention / Treatment
-----------------
* Other: Observational


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Having applied to the Gulhane Training and Research Hospital Geriatrics Polyclinic Being diagnosed with Alzheimer or Lewy Body Dementia or Vascular Dementia or Fronto-Temporal Dementia or Parkinson Disease Dementia Being at the age of 60 years or older Exclusion Criteria: Being under the age of 60 Patients with insufficient recorded data and follow-up for the study Patients who either have diagnosis or follow-up in another center. Patients who have severe dementia that prevents applying for outpatient clinic

Ages Eligible for Study
-----------------
Minimum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Dementia with Alzheimer<br>Patients previously diagnosed with Alzheimer disease would be included | Other: Observational<br>* Patients data were collected throughout the following time<br>|
| Dementia with Lewy Body Dementia<br>Patients previously diagnosed with Lewy Body Dementia would be included | Other: Observational<br>* Patients data were collected throughout the following time<br>|
| Dementia with Fronto-Temporal Dementia<br>Patients previously diagnosed with Fronto-Temporal Dementia would be included | Other: Observational<br>* Patients data were collected throughout the following time<br>|
| Dementia with Vascular Disease<br>Patients previously diagnosed with Dementia with Vascular Disease would be included | Other: Observational<br>* Patients data were collected throughout the following time<br>|
| Dementia with Parkinson Disease<br>Patients previously diagnosed with Dementia with Parkinson Disease would be included | Other: Observational<br>* Patients data were collected throughout the following time<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality | The event of death occuring during the follow-up period | 2 years | 
| Mini-Mental State Examination | It was performed to assess mental status. It gives an overall opinion on cognitive domains and tests orientation, registration, attention and calculation, recall, and language. Total scores on Mini-Mental State Examination range from 0 to 30, higher scores show better cognitive performance. | 2 years | 
| Barthel Index | It was used for assessing physical functioning as a part of the routine geriatric evaluation.where the ten performance items used. Those items defined as feeding, bathing, grooming, dressing, continence of bowel and bladder, toilet use, transfers (bed to chair and back), mobility (on level surfaces), and climbing stairs. Each item is scored on this scale, and the sum is obtained by adding the score of each item (range, 0-100; higher scores show better performance) | 2 years |