Correlation Between Postoperative Cognitive Dysfunction and Telomere Length in Patients With Non-cardiac Surgery

Study Overview
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Brief Summary
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To study on the Postoperative Cognitive Dysfunction: Correlations With Leukocyte telomere length。

Official Title
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Correlation Between Postoperative Cognitive Dysfunction and Telomere Length in Patients With Non-cardiac Surgery

Conditions
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Postoperative Cognitive Dysfunction

Intervention / Treatment
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* Diagnostic Test: Neuropsychology test


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Non-cardiac surgery patients; Age is greater than or equal to 65 years old; Han Nationality, mother tongue is chinese; ④The MMSE score:Illiteracy is greater than or equal to 17 points, primary school is greater than or equal to 20 points, higher secondary school is more than 24 points; ⑤The Geriatric Depression Scale (GDS) grade 1 or 2; ⑥The important function without serious heart, brain, liver, kidney, lung and other organs; The ASA class I or II; The people signed informed consent. Exclusion Criteria: The diagnosis of neurological and psychiatric disorders, such as Alzheimer's disease, Parkinson's syndrome, multiple sclerosis, schizophrenia, depression, etc.; ②Had severe head and face disease, trauma history or history of surgery; Had a history of influenza in 3 weeks; ④The serious body disease and tobacco, wine and other substance abuse history; ⑤The presence of malignant tumor with shorter survival disease.

Ages Eligible for Study
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Minimum Age: 60 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| study group<br>1000 Male and female patients undergoing non-cardiac surgery at the Affiliated Hospital of Xuzhou Medical University [Jiangsu China]. We do the neuropsychological tests, Mini-Mental score examination (MMSE) and olfaction test 1 day before (baseline) and 1 week,3 months,1 year and 3 years after surgery without safety issue.We also measure their preoperative leukocyte telomere length. | Diagnostic Test: Neuropsychology test<br>* We do the neuropsychological tests, Mini-Mental score examination (MMSE) and olfaction test 1 day before (baseline) and 1 week,3 months,1 year and 3 years after surgery without safety issue.<br>|
| control group<br>We enroll 50 healthy volunteers and do the neuropsychological tests, Mini-Mental score examination (MMSE) and olfaction test at 1 day (baseline), 1 week, 3 months, 1 year and 3 years without safety issue. | Diagnostic Test: Neuropsychology test<br>* We do the neuropsychological tests, Mini-Mental score examination (MMSE) and olfaction test 1 day before (baseline) and 1 week,3 months,1 year and 3 years after surgery without safety issue.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the neuropsychological test to measure cognitive function |  | 1 day before surgery(baseline) | 
| Mini-Mental score examination [MMSE] used for screening of dementia |  | 1 day before surgery(baseline) | 
| the leukocyte telomere length |  | on the surgery day | 
| the neuropsychological test to measure cognitive function |  | within the first 7 days (plus or minus 2 days) after surgery | 
| Mini-Mental score examination [MMSE] used for screening of dementia |  | within the first 7 days (plus or minus 2 days) after surgery | 
| the neuropsychological test to measure cognitive function |  | within the first 3 months (plus or minus 1 month) after surgery | 
| Mini-Mental score examination [MMSE] used for screening of dementia |  | within the first 3 months (plus or minus 1 month) after surgery | 
| the neuropsychological test to measure cognitive function |  | within the first 1 year (plus or minus 3 months) after surgery | 
| Mini-Mental score examination [MMSE] used for screening of dementia |  | within the first 1 year (plus or minus 3 months) after surgery | 
| the neuropsychological test to measure cognitive function |  | within the first 3 years (plus or minus 1 year) after surgery | 
| Mini-Mental score examination [MMSE] used for screening of dementia |  | within the first 3 years (plus or minus 1 year) after surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Postoperative Cognitive Dysfunction, Leukocyte Telomere Length