For A More Comfortable Bronchoscopy: Is Spray Catheter The Answer?

Study Overview
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Brief Summary
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Bronchoscopy is a commonly performed procedure for inpatients to visualize the airways when indicated. It is routinely done for both diagnostic (to lavage and biopsy the respiratory tract) and therapeutic purposes (to relief an obstruction or remove foreign bodies). Given the possible side effects of cough of varying severity this procedure can be uncomfortable to patients, some would even shy away from having a bronchoscopy even when it's medically indicated. Recently a spray catheter was designed to deliver more uniform anesthesia to the airways as compared to the conventional way of injecting the anesthesia into the bronchoscopy working channel. The investigators aim to conduct this study with the hope of improving patient care, providing comfortable procedures, helping more patients opt in for bronchoscopy when indicated.

Detailed Description
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Bronchoscopy is a commonly performed procedure for inpatients. It is routinely done for both diagnostic and therapeutic purposes. The physician in this procedure inserts the bronchoscopy tube that has a camera at its tip to visualize the airways and detect possible pathologies. When needed, he/she can take samples (biopsies), perform brochoalveolar lavage, remove foreign bodies, or relieve airway obstructions. The usual method of Bronchoscopic Anesthesia (BA) is conscious sedation combined with local anesthesia as it's more comfortable for the patients, with less chances of lidocaine toxicity. Local anesthesia is classically done using lidocaine injected through the bronchoscope's working channel. As the operator starts from the upper airway, they anesthetize each part as they go down to examine the lungs. The lidocaine will be delivered to the airway as it drips out of the working channel into the airway part closest to it. Side effects of this method is cough with varying frequencies/severity that may sometimes hinder the procedure. Recently, a spray catheter was designed and used, but mainly for EBUS (Endobronchial Ultrasound) and not for bronchoscopy.

Official Title
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For A More Comfortable Bronchoscopy: Is Spray Catheter The Answer?

Conditions
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Airway Complication of Anaesthesia

Intervention / Treatment
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* Device: BA by spray catheter (Olympus PW-205V)
* Other: BA classic anesthesia
* Drug: Anesthesia


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adult patients (18 years of age and above) Not mechanically ventilated Needing a bronchoscopy as determined by a referring or consulting physician/medical service Exclusion Criteria: Individuals below 18 years of age Pregnant women Terminally-ill patients Patients who are unable to consent in person Patients with contraindications for bronchoscopy (according to British Thoracic Society 2013 Guidelines this includes patients with acute myocardial infarction and patients in acute respiratory distress)

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: BA by spray catheter (Olympus PW-205V)<br>This group will be having the bronchoscopic anesthesia (lidocaine) injected through the spray catheter (Olympus PW-205V). | Device: BA by spray catheter (Olympus PW-205V)<br>* This group will be having the bronchoscopic anesthesia (lidocaine) injected through the spray catheter (Olympus PW-205V)<br>* Other names: Spray catheter;Drug: Anesthesia<br>* Both groups will receive lidocaine as the anesthesia for bronchoscopy<br>* Other names: Lidocaine;|
| Active Comparator: BA classic anesthesia<br>This group will be having the bronchoscopic anesthesia (lidocaine) injected through the bronchoscope's working channel. | Other: BA classic anesthesia<br>* This group will have the bronchoscopic anesthesia (lidocaine) injected through the bronchoscope's working channel.<br>Drug: Anesthesia<br>* Both groups will receive lidocaine as the anesthesia for bronchoscopy<br>* Other names: Lidocaine;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of coughing episodes during the bronchoscopy | Coughing data will be collected from both groups during the bronchoscopy | Day 1 | 
| Severity of cough during the bronchoscopy | Severity of cough data will be collected from both groups during the bronchoscopy | Day 1 | 
| Endotracheal sedations required to conduct the bronchoscopy | Endotracheal sedations required to conduct the bronchoscopy between the two groups. | Day 1 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Bronchoscopic anesthesia lidocaine, Spray Catheter, brochoalveolar lavage