Analysis of the Clinical and Histological Correlation of Oral Graft-Versus-Host-Disease (GVHD)

Study Overview
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Brief Summary
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Introduction: Graft-versus-host-disease (GVHD) is the major cause of morbidity and mortality in patients submitted to the Bone Marrow Transplantation (BMT). The oral manifestations can be very debilitating and interfere in the results of medical therapy, leading to systemic complications, committing the prognosis and quality of life of the patient. The early diagnosis can be done through biopsies of oral mucosa with or without apparent injury clinic. The association between the clinical and histopathological tables of GVHD, especially through the use of recent consensus established in these areas, can bring new benefits to physicians. Objective: This study aims to apply and compare the two classifications histological to GVHD, Horn (1995) and Consensus (2006) in specimens obtained from clinical oral lesions suggestive of GVHD; correlate them with clinical classification according Akpek (2001) and with the survival of the patients.

Detailed Description
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Methods: For this study we analyzed histological samples of oral mucosa of 10 patients with clinical diagnosis of GVHD, which have areas of epithelium, and salivary gland. The histopathological aspects were observed by the author of this work and his advisor, so blinded by applying the criteria for Horn and the Consensus. We consistency between the two classifications obtained and histological correlation with the clinical classification of GVHD (Akpek, 2001) and the curve of survival.

Official Title
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Clinical and Histological Evaluation of Chronic Graft-Versus Host Disease (cGVHD) in Oral Mucosa

Conditions
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Graft-Versus-Host Disease

Intervention / Treatment
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* Procedure: oral biopsy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: all patients with clinical signs of oral GVHD that underwent oral biopsy Exclusion Criteria: samples without epithelium or minor salivary glands
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Bone Marrow Transplantation<br> | Procedure: oral biopsy<br>* oral mucosa and salivary gland biopsy after bone marrow transplantation<br>* Other names: bone marrow transplantation;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The histological classification according Horn showed that in most cases there was presence of GVHD with low degrees of severity; Already classification of the Consensus showed that there were in full presence of GVHD of moderate degree. |  | during the survey data, and analysis of specimens | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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oral manifestations, bone marrow transplantation, adverse effects