Health-related Quality of Life in Adults After Veno-arterial Extra-Corporeal Membrane Oxygenation Which is a Salvage Therapy Used in Patients With Severe Respiratory or Cardiac Failure Who Have Not Responded to Maximal Conventional Medical Therapy

Study Overview
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Brief Summary
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Extracorporeal Membrane Oxygenation (ECMO) is a salvage therapy used in patients with refractory cardiogenic shock. This rescue technique is associated to a high mortality rate and to many complications that can impact the quality of life of the survivors. The aim of this study is to evaluate the Health-related quality of life in adults after veino-arterial Extra-Corporeal Membrane Oxygenation. The quality of life will be evaluated thanks to several methods : the Short Form 36, the EQ 5D 5L and the return to work status. Then, the investigators will analyze by subgroup the quality of life according to the cardiogenic shock etiology and try to determine the risk factors of an altered quality of life. The investigators will also evaluate current comorbidities of the patient thanks to the Groll Index.

Official Title
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Health-related Quality of Life in Adults After Veno-arterial Extra-Corporeal Membrane Oxygenation

Conditions
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Veno-arterial Extra-Corporeal Membrane Oxygenation, Health Related Quality of Life

Intervention / Treatment
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* Other: Evaluation of quality of life, comorbidities and return to work status


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adults >18 years Veno-arterial ECMO between April 2008 and December 2019 in NHC surgical intensive care of Strasbourg Affiliated to the French social security system Exclusion Criteria: - Patients under guardianship or with legal protection

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 95 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Evaluation of quality of life, comorbidities and return to work status|Quality of life will be evaluated thanks to several methods: Short Form 36, EQ 5D 5L and return to work status Questionnaires will be evaluated through postal and phone call at least 12 months after ECMO.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluation of health-related quality of life after veino-arterial ECMO | Quality of life will be evaluated by Short Form 36 ( score 0 to 100) | The quality of life will be evaluated from 1 to 12 years after the ECMO | 
| Evaluation of health-related quality of life after veino-arterial ECMO | EQ 5D 5L ( description of mobility, personal autonomy, routine activities, pain and discomfort, anxiety and depression and an analog visual scale) | The quality of life will be evaluated from 1 to 12 years after the ECMO | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Analysis by subgroup according to the cardiogenic shock etiology | 5 subgroups will be assessed according to the cardiogenic shock etiology: post cardiac surgery, post cardiac ischemia, pulmonary embolism or other right ventricle dysfunction, other etiology | The quality of life will be evaluated from 1 to 12 years after the ECMO | 
| Research of risk factors of an altered quality of life | 5 subgroups will be assessed according to the cardiogenic shock etiology: post cardiac surgery, post cardiac ischemia, pulmonary embolism or other right ventricle dysfunction, other etiology | The quality of life will be evaluated from 1 to 12 years after the ECMO | 
| Evaluation of the current comorbidities thanks to Groll index | 5 subgroups will be assessed according to the cardiogenic shock etiology: post cardiac surgery, post cardiac ischemia, pulmonary embolism or other right ventricle dysfunction, other etiology | The quality of life will be evaluated from 1 to 12 years after the ECMO |