Medication Regimen Complexity and Glycemic Control in Patients With Diabetes

Study Overview
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Brief Summary
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Polypharmacy is an alarming health issue that is defined as prescription of multiple medications, of which some are redundant or unnecessary. Due to comorbidities, diabetic patients are often prescribed multiple medications. Over prescribing occurs either due to, prescribing medications that are not indicated, continuation of certain medications beyond the time of indication, or prescribing more than one medication with the same effect. Improving glycaemic control is the cornerstone for the prevention and treatment of the diabetic complications.

Detailed Description
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Hypothesis In addition to the side effects and cost of the unnecessary medications, the investigators hypothesis is that poly-pharmacy will adversely affect patients' compliance with the necessary medications.The investigators propose that elimination of unnecessary medications might improve patients' compliance and consequently improve glycemic control diabetic patients.

Official Title
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Effect of Reducing Medication Regimen Complexity on Glycemic Control in Patients With Diabetes.

Conditions
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Diabetes Mellitus

Intervention / Treatment
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* Other: Medications review


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All diabetic patients who are eligible by fulfilling all of the following criteria: HGBA1c ≥7 mg/dl. 2) Poly-pharmacy: defined as the use of five or more medications. Non- compliance: patients were surveyed with both direct and indirect methods to identify non adherence. Exclusion Criteria: Exclusion after recruitment Any patient whose diabetic medications regimen changed after recruitment due to hospitalisation, illness, stress or patients preference, will be excluded.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Interventional Model Description: A prospective cohort study .The aim of this study to recruit a cohort of diabetic patients,eliminate unnecessary medications,aiming at improving adherence to anti-diabetic medications.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Diabetic patients with non-adherence and poly-pharmacy<br>Medications review. Elimination of all unnecessary prescription to cut down the number of medications to the least possible number. | Other: Medications review<br>* Medications review. Elimination of all unnecessary prescription to cut down the number of medications to the least possible number. This is in line with the best practice guidelines.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Hemoglobin A1c | measurement of hemoglobin A1c to determine glycemic control. | 3 months |