Beneficial Effect of Xylose Consumption on Postprandial Hyperglycemia

Study Overview
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Brief Summary
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The present study determined the effect of Xylose consumption on postprandial hyperglycemia in normal (n=25) and hyperglycemic subjects (n=50).

Detailed Description
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In this double-blind crossover designed study, Participants were randomly assigned to consume a sucrose drink (Control, sucrose 50g + deionized water 100g) or a sucrose drink additionally containing 5 g (Test 1, sucrose : xylose = 10:1), 3.33 g (Test 2, sucrose : xylose = 15:1) or 2.5 g (Test 3, sucrose : xylose = 20:1) of D-xylose with a week interval.

Official Title
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Beneficial Effect of Xylose Consumption on Postprandial Hyperglycemia in Subjects With Normal Glucose Level and Impaired Fasting Glucose

Conditions
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Postprandial Hyperglycemia

Intervention / Treatment
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* Dietary Supplement: Test 1
* Dietary Supplement: Test 2
* Dietary Supplement: Test 3
* Dietary Supplement: Control


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 1) healthy subject or Impaired fasting glucose (fasting serum glucose between 100 and 125 mg/dL) Exclusion Criteria: history of taking an insulin-injection or oral hypoglycemic agents evidence of alcohol abuse or alcoholism pregnancy or breast feeding chronic gastrointestinal disorder seriously abnormal liver or renal function an occupation at risk of death when hypoglycemia occurs

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Control group<br>sucrose drink (Control, sucrose 50g + deionized water 100g) | Dietary Supplement: Control<br>* sucrose 50 g + deionized water 100 g<br>|
| Active Comparator: 5 g xylose group<br>5 g xylose (Test 1, sucrose : xylose = 10:1), | Dietary Supplement: Test 1<br>* sucrose : xylose = 10:1, sucrose 50 g + xylose 5 g + deionized water 95 g<br>|
| Active Comparator: 3.33 g xylose group<br>3.33 g xylose (Test 2, sucrose : xylose = 15:1) | Dietary Supplement: Test 2<br>* sucrose : xylose = 15:1, sucrose 50 g + xylose 3.33 g + deionized water 96.67 g<br>|
| Active Comparator: 2.5 g xylose group<br>2.5 g xylose (Test 3, sucrose : xylose = 20:1) | Dietary Supplement: Test 3<br>* sucrose : xylose = 20:1, sucrose 50 g + xylose 2.5 g + deionized water 97.5 g<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of serum glucose levels |  | a week interval | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of serum insulin levels |  | a week interval | 
| Change of serum C-peptide levels |  | a week interval | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Xylose, prediabetes, postprandial hyperglycemia, glucose