Cognitive Changes in Childs After Anesthesia / Surgery

Study Overview
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Brief Summary
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The role of surgical stress and anesthesia is unknown in the early childhood. In vitro and animal studies showed a risk for treatment with anesthesia in the developmental brain. Furthermore, stress is also an important risk factor for cognitive impairment. Therefore, the investigators want to investigate in a clinical prospective cohort study the role anesthesia and surgery on different cognitive parameters and self-controling mechanisms in children under 3 years.

Detailed Description
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In order to investigate the role of anesthesia and / or surgery on cognitive abilities the investigators want to perform a prospective cohort study in children under 3 years. Three groups should be compared: i) control without anesthesia / surgery, ii) children with only anesthesia, and iii) children with both surgery and anesthesia. All children will be investigate before and after intervention. Different behavioral scales will be used for detailed cognitive abilities and self-regulatory skills.

Official Title
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Role of Anesthesia / Surgery on Cognitive Function in Child

Conditions
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Behavioral

Intervention / Treatment
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* Behavioral: anesthesia - surgery


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 9 month to 3 years with or without anesthesia / surgery Exclusion Criteria: Psychiatrical, neurological, oncological diseases

Ages Eligible for Study
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Minimum Age: 9 Months
Maximum Age: 3 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| control<br>children without anesthesia / surgery | |
| anesthesia<br>children with anesthesia for diagnostic reason | Behavioral: anesthesia - surgery<br> <br> |
| surgery<br>children with anesthesia / surgery | Behavioral: anesthesia - surgery<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Global cognitive abilities | Bayley Scale | 4-6 weeks | 
| Global cognitive abilities | MONDEY (Milestone of Normal Development in Early Years) Scale | 4-6 weeks | 
| Global cognitive abilities | Assessment of temperament with the Infant Behavior Questionnaire Revised (IBQ-R) questionnaire | 4-6 weeks | 
| Global cognitive abilities | Early Childhood Behavior Questionnaire (ECBQ) questionnaire | 4-6 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| surgery-associated data | reason of surgery | 1 - 3 days | 
| surgery-associated data | date of birth | 1 day | 
| surgery-associated data | length of surgery (h:min) | 1 day | 
| surgery-associated data | kind and quantity of anesthesia and medication (number) | 1 day | 
| surgery-associated data | Age (month) | 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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cognition, anesthesia, surgery, stress, child