Effects of Rehydration During Physical Exercise on Acute Kidney Injury Biomarkers

Study Overview
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Brief Summary
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Rehydration during and after physical exercise is essential to avoid acute kidney injury. Soft drinks are commonly used during exercise. High intake of carbohydrates is leading to obesity and metabolic disorders. Fructose intake is leading to uric acid abnormalities and kidney injury. 30 healthy soccer players will be studied. During four training sessions subjects will intake 500 ml 7% soft drinks containing glucose, fructose, saccharose or xylitol. Changes in acute kidney injury markers, markers of kidney tubular function as well as changes in CRP, glucose, cholesterol and uric acid levels will be studied..

Official Title
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Effects of Rehydration During Physical Exercise on Acute Kidney Injury Biomarkers

Conditions
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Acute Kidney Injury

Intervention / Treatment
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* Dietary Supplement: Fructose/glucose/xylitol/saccharose


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age above 18 years well-trained soccer players informed consent Exclusion Criteria: chronic diseases, especially kidney problems sigificant changes in urinalysis creatinine level above normal values

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Experimental: glucose - fructose - xylitol - saccharose<br>glucose 35 g (500ml of 7% solution); fructose 35 g (500ml of 7% solution); xylitol 35 g (500ml of 7% solution); saccharose 35 g (500ml of 7% solution) | Dietary Supplement: Fructose/glucose/xylitol/saccharose<br>* Intervention: rehydration with glucose solution. Glucose will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m. Intervention: rehydration with fructose solution. Fructose will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m. Intervention: rehydration with xylitol solution. Xylitol will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m. Intervention: rehydration with sucrose solution Saccharose will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m.<br>|
| Active Comparator: Experimental: fructose - glucose - saccharose - xylitol<br>glucose 35 g (500ml of 7% solution); fructose 35 g (500ml of 7% solution); xylitol 35 g (500ml of 7% solution); saccharose 35 g (500ml of 7% solution) | Dietary Supplement: Fructose/glucose/xylitol/saccharose<br>* Intervention: rehydration with glucose solution. Glucose will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m. Intervention: rehydration with fructose solution. Fructose will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m. Intervention: rehydration with xylitol solution. Xylitol will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m. Intervention: rehydration with sucrose solution Saccharose will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m.<br>|
| Active Comparator: Experimental: xylitol - saccharose - glucose - fructose<br>glucose 35 g (500ml of 7% solution); fructose 35 g (500ml of 7% solution); xylitol 35 g (500ml of 7% solution); saccharose 35 g (500ml of 7% solution) | Dietary Supplement: Fructose/glucose/xylitol/saccharose<br>* Intervention: rehydration with glucose solution. Glucose will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m. Intervention: rehydration with fructose solution. Fructose will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m. Intervention: rehydration with xylitol solution. Xylitol will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m. Intervention: rehydration with sucrose solution Saccharose will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m.<br>|
| Active Comparator: Experimental: saccharose - xylitol - fructose - glucose<br>glucose 35 g (500ml of 7% solution); fructose 35 g (500ml of 7% solution); xylitol 35 g (500ml of 7% solution); saccharose 35 g (500ml of 7% solution) | Dietary Supplement: Fructose/glucose/xylitol/saccharose<br>* Intervention: rehydration with glucose solution. Glucose will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m. Intervention: rehydration with fructose solution. Fructose will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m. Intervention: rehydration with xylitol solution. Xylitol will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m. Intervention: rehydration with sucrose solution Saccharose will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in urinary AKI biomarkers (urianry NGAL, urinary KIM -1, urinary cystatin-C) after physical exercise |  | after 60-90 min of pysical exercise | 
| Changes in fractional uric acid excretion |  | after 60-90 min of pysical exercise | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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biomarker, albuminuria, uric acid