Ozone Therapy in Endodontic Practice, in Vivo Study

Study Overview
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Brief Summary
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The ozone therapy has been coming up as a new therapeutic modality. Medicine has been practicing since XIX century and counted great results. It is indicated for the treatment of 260 different pathologies. The researches in Dentistry has showed promising results, indicating a wide spread action in whole dental specialties. The great oxidative power of ozone provides a great antimicrobial effect and it increases the adenosine triphosphate (ATP) synthesis that can be considered as a general improvement of the cell metabolism, which can potentize the repair process. Thus, these facts justify the present study which will assess the increase of speed of apical periodontite repair.

Official Title
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Phase 4 - Ozone Therapy in Endodontic Practice, in Vivo Study

Conditions
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Primary Apical Periodontite

Intervention / Treatment
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* Drug: Ozone
* Drug: Control (no last irrigation)
* Drug: Aqueous Ozone


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy patients Radiographic evidence of apical periodontite No previous root canal treatment Exclusion Criteria: Unhealthy patients Regular response to sensibility test Previous root canal treatment

Ages Eligible for Study
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Minimum Age: 13 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Ozone Gas<br>Endodontic protocol preconized by University of Sao Paulo associated to ozone gas 40 mg/L | Drug: Ozone<br>* Regular endodontic protocol preconized by University of Sao Paulo. Root canal irrigation with 1% Sodium Hypochlorite associated to Endo PTC (10mL), final irrigation with EDTA-T 17% remaining for 3 minutes. After a last foaming with ozone gas (Philozon, Santa Catarina, Brazil) at 40mg/L concentration.<br>* Other names: Group 2;|
| Active Comparator: Control<br>Regular endodontic protocol preconized by University of Sao Paulo | Drug: Control (no last irrigation)<br>* Regular endodontic protocol preconized by University of Sao Paulo. Root canal irrigation with 1% Sodium Hypochlorite associated to Endo PTC (10mL), final irrigation with EDTA-T 17% remaining for 3 minutes.<br>* Other names: Group 1;|
| Experimental: Aqueous Ozone<br>Endodontic protocol preconized by University of Sao Paulo associated to Aqueous ozone 40mg/L | Drug: Aqueous Ozone<br>* Regular endodontic protocol preconized by University of Sao Paulo. Root canal irrigation with 1% Sodium Hypochlorite associated to Endo PTC (10mL), final irrigation with EDTA-T 17% remaining for 3 minutes. A last irrigation with 10mL of ozonated water at 40mg/mL concentration<br>* Other names: Group 3;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Acceleration in repair by healing of apical periodontite |  | 3 months |