Subclinical Atherosclerosis Using Dual-source CT Coronary Angiography in Chinese Adults With Different Glycaemic Status

Study Overview
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Brief Summary
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Part I: Survey of Coronary Artery Calcification and Stenosis in Participants with Different Glycaemic Status Aims: To evaluate coronary artery calcification and stenosis in community-dwelling adults with different glycaemic status, using dual-source CT angiography (CTA) Study Subjects and Methods: 200 adults with normal glucose regulation (NGR), 200 with impaired glucose regulation (IGR) and 200 with type 2 diabetes were recruited from an urban community of Shanghai, who then underwent a comprehensive examination including questionnaire, anthropometric measurements, biochemical analysis and CTA. Part II: Follow-up of Cardiovascular Events and Re-evaluation of Coronary Artery Calcification and Stenosis Aims and Methods: To investigate the development of cardiovascular diseases in subjects recruited in part I and re-evaluate coronary artery calcification and stenosis using CTA after 3-year follow-up To identify the predictive value of coronary artery calcification and stenosis with future risks of cardiovascular diseases and the possible development of coronary artery disorders among participants with different glycaemic status

Official Title
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Assessment of Subclinical Atherosclerosis Using Dual-source Computed Tomography Coronary Angiography in Chinese Adults With Different Glycaemic Status

Conditions
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Thromboembolism

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age between 40 and 70 years old Gender: males and females Provide written informed consent Satisfactory compliance Exclusion Criteria: History of cardiovascular diseases Allergy to iodine Exposure to radiation within last 3 months ALT more than 100IU/L, or serum creatine more than 133μmol/l [1.5mg/dl] or GFR less than 60ml/min Heart rate more than 100 bpm or severe arrhythmia Malignancy, myocardial infection, acute hepatitis or other major diseases

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Impaired glucose regulation<br>This group of subjects was diagnosed as impaired glucose regulation using oral glucose tolerance test. | |
| Type 2 diabetes<br>This group of subjects was diagnosed as type 2 diabetes using oral glucose tolerance test. | |
| Normal glucose regulation<br>This group of subjects was considered normal regarding glucose metabolism using oral glucose tolerance test. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of participants who will develop cardiovascular events during follow-up | Cardiovascular events include non-fatal myocardial infarction, non-fatal stroke and cardiovascular death. The progression of coronary artery calcium and stenosis is also evaluated at the final visit. | 3 years |