The Impact of Liver Cirrhosis on Outcomes in Trauma Patients

Study Overview
=================
Brief Summary
-----------------
Given that there are only a few studies on the effects of cirrhosis on trauma patients and none have addressed the impact cirrhosis has on the incidence of infections, it is important that we study this to determine the mortality in cirrhotic trauma patients and ascertain the incidence of infectious complications in these patients. We hypothesize that trauma patients with cirrhosis will have higher rates of mortality and infectious complications.

Detailed Description
-----------------
There have been a select few studies addressing the effects of cirrhosis on trauma patients. These studies show an increase in morbidity and mortality. However, there is limitation in the depth and breadth of analysis. The primary aim of this study is to determine the mortality rates in cirrhotic trauma patients with a secondary end-point being the determination of the incidence of infections associated with these patients. Given that there are only a few studies on the effects of cirrhosis on trauma patients and none have addressed the impact cirrhosis has on the incidence of infections, it is important that we study this to determine the mortality in cirrhotic trauma patients and ascertain the incidence of infectious complications in these patients. PI hypothesizes that trauma patients with cirrhosis will have higher rates of mortality and infectious complications.

Official Title
-----------------
The Impact of Liver Cirrhosis on Outcomes in Trauma Patients

Conditions
-----------------
Cirrhosis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Cirrhotic trauma patients in the United States within 2010-2018 Patients ≥ 18 years old Exclusion Criteria: Patients less than 18 years old

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality | Patient death | 2010-2018 | 
| Incidence of infectious complications | Incidents of complications with infections | 2010-2018 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patient demographics | demographics of patients | 2010-2018 | 
| vital signs; clinical measurements | clinical measurements | 2010-2018 | 
| vital signs; pulse rate | pulse rate (bpm) | 2010-2018 | 
| vital signs; temperature | temperature | 2010-2018 | 
| vital signs; respiration rate | respiration rate | 2010-2018 | 
| vital signs; blood pressure | blood pressure | 2010-2018 | 
| injury characteristics | characteristics of injuries | 2010-2018 | 
| hospital and ICU lengths of stay | length of days patients stays in hospital/ICU | 2010-2018 | 
| transfusion data | data regarding transfusions | 2010-2018 | 
| alcohol use indicator | indicator of alcohol use | 2010-2018 | 
| drug use indicator | indicator of drug use | 2010-2018 | 
| ventilator days | days on ventilator | 2010-2018 | 
| Abbreviated Injury Scale | abbreviated injury scale score | 2010-2018 | 
| Glasgow Coma Scale | glasgow coma scale score | 2010-2018 | 
| Injury Severity Score | score of injury | 2010-2018 | 
| discharge date | date of discharge | 2010-2018 | 
| arrival date | date of arrival | 2010-2018 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
cirrhotic trauma