Emotional Prosody Recognition and Decision Making Inf fMRI and Vulnerability to Suicide

Study Overview
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Brief Summary
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Suicide is known to be frequent in depression, and in most of the psychiatric diseases. But as it can occur in patients with no psychiatric illness and doesn't occur in every patients with psychiatric illness, it has to be considered henceforth as a specific vulnerability. This trial will study two fMRI paradigms, emotional prosody recognition and decision making, in order to characterize emotional and cognitive trait factors in a population of patients vulnerable to suicide. Four different groups will be constituted : depressed suicide attempters, depressed patients with past history of suicidal acts, depressed patients with no history of suicidal acts and healthy controls. The main goal will be to correlate fMRI activation during the two paradigms in subjects vulnerable to suicide. The secondary goals will be to characterize emotional and cognitive trait factors in these subjects, to demonstrate that those characteristics are independent from depression and to correlate these trait factors with socio-demographic and clinical features with fMRI activations.

Official Title
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Emotional Prosody Recognition and Decision Making Inf fMRI and Vulnerability to Suicide

Conditions
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Suicide

Intervention / Treatment
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* Other: fMRI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Right-handed, Depressed suicide attempters for the first group, Depressed patients with past history of suicidal acts for the second group, Depressed patients with no history of suicidal acts for the third group, Healthy controls for the fourth group. Exclusion Criteria: Another psychiatric trouble than depression, Another psychotrope treatment than SSRI/SNRI and/or benzodiazepine at inclusion and/or one month before, For the first and secand groups : more than fous suicidals acts within the past 3 years, Deficits that do not allow test realisation (visual audition troubles, cognitif deficits, Prosopagnosia, Pregnancy, Severe central nervous system disease or somatic disease, MRI contra-indication, Major benefiting from a legal protective measure, No coverage care.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Depressed suicide attempters<br>20 subjects | Other: fMRI<br>* two fMRI paradigms, emotional prosody recognition and decision making<br>|
| Experimental: Depressed patients with past history of<br>20 subjects | Other: fMRI<br>* two fMRI paradigms, emotional prosody recognition and decision making<br>|
| Experimental: Depressed patients with no history of<br>20 subjects | Other: fMRI<br>* two fMRI paradigms, emotional prosody recognition and decision making<br>|
| Placebo Comparator: Healthy controls<br>20 subjects | Other: fMRI<br>* two fMRI paradigms, emotional prosody recognition and decision making<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| fMRI activation area |  | 1 day |