linjc16/ctgov huggingface dataset:
Why in Hospital After VATS Lobectomy

Study Overview
=================
Brief Summary
-----------------
The study aims to identify specific or potential reasons that prolong the length of hospital stay after video-assisted thoracoscopic surgery lobectomy. The hypothesis is that patients who are still in hospital after video-assisted thoracoscopic surgery lobectomy are associated with prolonged air leak, infection, pneumonia, atrial fibrillation or other complications or social factors.

Official Title
-----------------
Why Are Patients Still in Hospital After Video-Assisted Thoracoscopic Surgery Lobectomy?

Conditions
-----------------
Infection, Atrial Fibrillation, Carcinoma, Non-Small-Cell Lung, Pain, Postoperative, Postoperative Nausea and Vomiting, Air Leakage

Intervention / Treatment
-----------------
* Other: Prolong in-hospital stay


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients referred to elective VATS lobectomy Speaks and understands Danish Informed consent obtained Exclusion Criteria: •Age < 18 years

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients underwent VATS lobectomy<br>All consecutive patients scheduled for video-assisted thoracoscopic surgery lobectomy. | Other: Prolong in-hospital stay<br>* Patients have a longer length of hospital stay than the common recommendation.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Length of postoperative hospital stay |  | Through study completion, an average of 2 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number and frequency of postoperative complications |  | Up to 30 days | 
| Numeric rating scale for postoperative pain in hospitalization | Patients are scored using a numeric rating scale ranging from 0 (no pain) to 10 (excruciating pain) per day. | Through study completion, an average of 2 days | 
| Drainage duration | The criteria of drain removal is that air leak was consistently below 20 ml/min for at least 12 hours and fluid production was non-bloody and non-chylous without an upper volume limit. | Duration from postoperative chest tube placement to potential removal, an average of 2 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
in hospital, lobectomy, video-assisted thoracoscopic surgery
AVANDIA With Glyburide In African American And Hispanic Patients With Type 2 Diabetes Not Controlled by Glyburide Alone

Study Overview
=================
Brief Summary
-----------------
This study was designed to evaluate the safety and efficacy of AVANDIA (rosiglitazone) (8mg once daily) in African American and Hispanic patients with type 2 diabetes mellitus. As microvascular and macrovascular disease are significant contributors to diabetes morbidity and mortality and previous studies suggest that the thiazolidinedione compounds could have potentially beneficial vascular effects, the effects of rosiglitazone therapy on serum parameters associated with endothelial dysfunction, vascular inflammation and impaired fibrinolysis were examined in this study. Improvement in these parameters suggests that rosiglitazone may provide an additional beneficial vascular effect, apart from its ability to improve glycemic control.

Official Title
-----------------
A 24-Week Randomized, Double-blind Study to Evaluate the Efficacy, Safety and Tolerability of AVANDIA (8mg Once Daily) in Combination With Glyburide in African American and Hispanic Patients With Type 2 Diabetes Mellitus Who Are Inadequately Controlled on Glyburide Monotherapy

Conditions
-----------------
Diabetes Mellitus, Type 2

Intervention / Treatment
-----------------
* Drug: Rosiglitazone


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: African American or Hispanic. Type 2 diabetes mellitus. FPG>=140mg/dL plus HbA1c>=7.5% whilst receiving SU monotherapy. Exclusion criteria: Patients who use insulin. Clinically significant liver, kidney or heart disease, including high blood pressure.

Ages Eligible for Study
-----------------
Minimum Age: 21 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Rosiglitazone|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Efficacy of rosiglitazone combined with glyburide to glyburide monotherapy in reducing glycosylated hemoglobin (HbA1c). |  | 24 Weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Efficacy of rosiglitazone combined with glyburide to glyburide monotherapy upon FPG, c-peptide, HOMA and responder rates. |  | 24 Weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Rosiglitazone, Glyburide, Type 2 Diabetes Mellitus, African American, Hispanic
The Ideal Length of the Nasotracheal Tube Considering Nasotracheal Tube Size

Study Overview
=================
Brief Summary
-----------------
The nasotracheal intubation is preferred for oral surgery; it provides an easier view of the surgical field. However, nasotracheal tubes are produced by foreign countries. Tubes are often not fitted in anatomy of Korean people because of small nostril. When the size of the tube is chosen by nostril size, the length of nasotracheal tube is not appropriate to the glottis. The aim of this study is to evaluate the appropriateness of the tube depth and to suggest the ideal length of the nasotracheal tube during the intubation of the selected tracheal tube in consideration of the size of the nasal cavity in Koreans. 146 patients (73 males and 73 females) who are scheduled for nasal intubation for general anesthesia will be enrolled. The primary outcome is the ideal length of tube that allows the distance from the vocal cords to the proximal portion of the tube cuff to be greater than 2 cm and the tip of the intubated tube to be located 5 ± 2 cm above the tracheal carina. The size of nostril, length from the nare to the carina and vocal cord are measured.

Official Title
-----------------
The Ideal Length of the Nasotracheal Tube Considering Nasotracheal Tube Size

Conditions
-----------------
Nasotracheal Intubation for General Anesthesia

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 1. Patients who are scheduled for nasotracheal intubation for general anesthesia Exclusion Criteria: age<20 years ASA class III or more pregnancy emergency surgery nasal airway disease expected difficult intubation (difficult intubation history, Modified Mallampati score 4, mouth opening <2cm, facial anomaly) cervical movement disorder (cervical disease, cervical pain)

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| male<br> | |
| female<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the ideal length of the nasotracheal tube during the intubation of the selected tracheal tube in consideration of the size of the nasal cavity in Koreans | the ideal length of tube that allows the distance from the vocal cords to the proximal portion of the tube cuff to be greater than 2 cm and the tip of the intubated tube to be located 5 ± 2 cm above the tracheal carina. | through study completion, an average of 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Intubation, Intratracheal, Nasopharynx
Detection Cell Free DNA in Lung Cancer Patients

Study Overview
=================
Brief Summary
-----------------
third generation of EGFR-TKIs is the newest target therapy for NSCLC. However, we did not known the specific mechanisms for those non-responders and patients grow resistance.Next generation sequencing is current the most sensitive and specific method to exam gene mutation, diversion etc. By consistently detect the cf-DNA, we could possibly find out the mechanisms of response and resistance.

Detailed Description
-----------------
Study backgroud: third generation of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) is the newest target therapy for non small cell lung cancer (NSCLC). Two major study published in NEJM show that the overall response rate is about 60%-70%, with a progression free survival about 10 months. However, we did not known the specific mechanisms for those non-responders and patients grow resistance. Next generation sequencing is current the most sensitive and specific method to exam gene mutation, diversion etc. By consistently detect the cf-DNA, we could possibly find out the mechanisms of response and resistance. Eligible patients received 3rd generation EGFR-TKIs (AZD9291 and AVITINIB) were enrolled into this study. Tumor tissue sample within 6 months, and 10ml periphereal blood samples were collected at baseline. After treatment initiation, 10ml periphereal blood would be collected at every image testing time point until disease progression. Blood samples will be draw using EDTA tube and centerfuged within 2 hours and store in -80 refrigerator. NGS testing will cover target genes of NSCLC.

Official Title
-----------------
Using Next Generation Sequencing (NGS) Method to Detect Circulating Free DNA (Cf-DNA) and Explore the Resistance and Prognosic Mechanism of Third Generation Epidermal Growth Factor Receptor (EGFR) Tyrosine-kinase Inhibitor (TKI) in Advanced Non-small Cell Lung Cancer (NSCLC) Patients: a Single Center Study

Conditions
-----------------
Non-small Cell Lung Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: pathologically confirmed non small cell lung cancer. harboured with positive EGFR mutation (19 exon deletion, L858R、G719X、L861Q mutation) reliable patients history data. Exclusion Criteria: pathologically not confirmed non small cell lung cancer. multiple primary cancer.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| cf-DNA change from baseline | Using next generation sequencing (NGS) method to detect circulating free DNA (cf-DNA) in patients receive third generation EGFR-TKI, periphereal blood sample were collected at baseline and every 2 months to disease progression. | baseline and every 2 months up to 36 months or first documented progression disease. |
Color Stability of Two Different Resin Matrix Ceramics

Study Overview
=================
Brief Summary
-----------------
This is in vivo study aimed to evaluate the color stability of the newly introduced resin ceramic matrix (cerasmart )& (vita-enamic ) after a one year

Detailed Description
-----------------
This is in vivo randomized clinical trial aimed to evaluate the color stability and patient satisfaction of the newly introduced resin ceramic matrix (cerasmart )& (vita-enamic ) in posterior endodontically treated teeth through one year follow-up

Official Title
-----------------
Color Stability of Two Different Resin Matrix Ceramics: Randomized Clinical Trial.

Conditions
-----------------
Dental Restoration

Intervention / Treatment
-----------------
* Procedure: cerasmart
* Procedure: enamic


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: diagnose need for restoration in endo treated posterior teeth good general health and oral health occlusal stability Exclusion Criteria: smoking pregnancy use drugs that affect oral health Para functional habits

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: patient with endo treated first molar
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Enamic group<br>patient in this group received a restoration with enamic material | Procedure: enamic<br>* the patient received a crown made of enamic ceramic<br>|
| Active Comparator: Cerasmart group<br>patient in this group received a restoration with Cerasmart material | Procedure: cerasmart<br>* the patient received a crown made of cerasmart ceramic<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| color change | measurement of restoration using digital spectrophotometer | 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| patient satisfaction | patient satisfaction is measured self questionnaire to patient consist of 5 questions with 4 answers each answer take a score from 1 to 5 where 1 is the patient is not satisfied at all and 5 is the patient is totally satisfied | 12 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
ceramics, color, stability, resin Matrix
Impact of Papillary Microcarcinoma Terminology on Patients Treatment Preferences: a Cross Sectional Survey

Study Overview
=================
Brief Summary
-----------------
To explore how a clinical sample of patients with thyroid nodules (men and women) with no history of thyroid cancer would make decisions about treatments based on different terminology used to describe papillary thyroid cancer (with and without the cancer term).

Official Title
-----------------
Impact of Papillary Microcarcinoma Terminology on Patients Treatment Preferences

Conditions
-----------------
Thyroid Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: able to complete a survey Exclusion Criteria: None

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Treatment choice |  | one year |
Retrospective Clinical Evaluation of Nano-hybrid-composite Denture Teeth

Study Overview
=================
Brief Summary
-----------------
This retrospective study investigates the longevity of dentures with SR Phonares II teeth after a wearing period of more than 10 years. The primary objective is to assess the survival rate of dentures with SR Phonares II teeth after more than 10 years. The secondary objectives asses the quality of the dentures concerning aesthetic, functional and biological properties.

Official Title
-----------------
Retrospective Clinical Evaluation of Nano-hybrid-composite Denture Teeth SR Phonares II

Conditions
-----------------
Edentulous Mouth, Dental Prosthesis Failure

Intervention / Treatment
-----------------
* Device: Examination of dentures with SR Phonares II teeth


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: informed consent signed and understood by the subject partial or full denture with SR Phonares II teeth dentures delivered in the internal clinic between August 2010 and August 2012 to be able to visit the internal clinic (Exception: Patients with limited mobility are also included if another person can carry the dentures to the internal clinic of Ivoclar Vivadent AG for the examination.) Exclusion Criteria: patient does not wear the dentures regularly health status (physical and mental) does not allow participation.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Interventional Model Description: retrospective study
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Examination of dentures with SR Phonares II teeth<br> | Device: Examination of dentures with SR Phonares II teeth<br>* The intraoral situation will be examined similar to a standard dental examination. The dentures are then removed, cleaned and examined extraoral. Pictures and an impression of the dentures are taken.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Survival rate of dentures with SR Phonares II teeth | Examination by dentist | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quality of the dentures concerning aesthetic, functional and biological properties | Parameters are evaluated according to adopted FDI criteria by the dentist | 6 months |
Health Care Management for the Elderly in Community Through Screening

Study Overview
=================
Brief Summary
-----------------
Depression in late life has been associated with losses in functioning and quality of life, mortality, and increased health care costs. Although late life depression can be successfully treated with antidepressant medication or psychotherapy, few older adults receive adequate trials of such treatment in community in Korea. Barriers, such as loss of loved ones, medical illnesses, and social stigma associated with depression, lack of social and financial support, to effective treatment of depression can be especially problematic for older adult. Screening has been valuable in overcoming barriers to diagnosis. Over 60 year old community dwelling people will be screened for symptoms of four geriatric conditions (depression, dementia, urinary incontinence, and sleep disorder). Those who will be screened positive for each condition will be refer to clinic for diagnosis. Among them only those cases confirmed as depression by psychiatrists will be enrolled in this study. Enrolled patients will be randomly assigned to either case management or usual care conditions. The objective of the study is to test whether a system of screening, assessment, and follow-up provided by case manager improves in recognizing the target geriatric conditions (depression, dementia, urinary incontinence, and sleep disorder) and healthcare outcomes.

Conditions
-----------------
Major Depressive Disorders, Senile; Depression

Intervention / Treatment
-----------------
* Other: case management


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: over 60 year old having medicare insurance Exclusion Criteria: dementia and other psychiatric disorders

Ages Eligible for Study
-----------------
Minimum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Screening
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: case management<br>case management regulary | Other: case management<br>* confirmation of hospital visit date, checking the adverse effect and treatment compliance<br>|
| No Intervention: Control<br>usual care | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Geriatric Depression Score |  | 6 months after baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| quality of life |  | 6 months after baseline | 
| treatment compliance |  | 6 months after baseline | 
| suicide ideation |  | 6 months after baseline | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Screening, depression, case management