Effects of Ten-Weeks Power Training on Neuromuscular Performance, Heart Rate Variability, Sleep Quality and Mobility in Persons With Multiple Sclerosis

Study Overview
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Brief Summary
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Multiple Sclerosis (ME) is a degenerative, inflammatory and autoimmune demyelinating disease of the central nervous system, characterized by demyelination due to inflammation and degeneration of the myelin sheaths enveloping nerves of the eye, periventricular grey matter, brain, spinal cord and brainstem. The symptoms associated with MS include symptomatic fatigue, muscle weakness, ataxia, mobility and balance problems or cognitive problems. Strength training has been shown to improve strength and mobility in persons with MS.

Official Title
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Effects of Ten-Weeks Resistance Training on Neuromuscular Performance, Heart Rate Variability, Sleep Quality and Mobility in Persons With Multiple Sclerosis

Conditions
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Multiple Sclerosis

Intervention / Treatment
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* Other: Resistance training
* Other: Testing sessions


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: mild or moderate disability with clinical mild spastic-ataxic gait disorder. stable phase of the disease. Exclusion Criteria: Expanded Disability Status Scale (EDSS) < 6. relapsing disease within the preceding 12 months. corticosteroid treatment within the last months before study inclusion.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Control Group<br>Only testing sessions | Other: Testing sessions<br>* Testing sessions<br>|
| Experimental: Resistance training group<br>Ten weeks of resistance training | Other: Resistance training<br>* Ten weeks of resistance training<br>Other: Testing sessions<br>* Testing sessions<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Maximal Voluntary Isometric Contraction of Knee Extension |  | Before the program training | 
| Maximal Voluntary Isometric Contraction of Knee Extension |  | After 10 weeks | 
| Rate of Force Development |  | Before the program training | 
| Rate of Force Development |  | After 10 weeks | 
| Central Activation Ratio |  | Before the program training | 
| Central Activation Ratio |  | After 10 weeks | 
| Spasticity | Pendulum test | Before the program training | 
| Spasticity | Pendulum test | After 10 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Walking speed | Test 10 m-walks | Before the program training | 
| Walking speed | Test 10 m-walks | After 10 weeks | 
| Static balance | Romberg Test with eyes open and closed. Analysis with force plates | Before the program training | 
| Static balance | Romberg Test with eyes open and closed. Analysis with force plates | After 10 weeks | 
| Functional capacity | Sit to stand test | Before the program training | 
| Functional capacity | Sit to stand test | After 10 weeks | 
| Heart Rate Variability | Sleeping Heart Rate Variability | Before the program training | 
| Heart Rate Variability | Sleeping Heart Rate Variability | After 10 weeks | 
| Sleep Quality | Karolinska Sleep Diary and Acelerometry | Before the program training | 
| Sleep Quality | Karolinska Sleep Diary and Acelerometry | After 10 weeks |