Association Between Multiple Coagulation-related Factors and Lymph Node Metastasis in Patients With Gastric Cancer: A Retrospective Cohort Study

Study Overview
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Brief Summary
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We initially selected a total of 1128 patients with primary gastric cancer who presented at Shandong Provincial Hospital between January 2018 and October 2022, and retrospectively collected their clinical and pathological data. And retrospectively analyzed preoperative baseline characteristics, preoperative laboratory tests, and postoperative pathological results for these patients

Official Title
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Association Between Multiple Coagulation-related Factors and Lymph Node Metastasis in Patients With Gastric Cancer: A Retrospective Cohort Study

Conditions
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Gastric Cancer Stage, Lymph Node Metastasis

Intervention / Treatment
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* Diagnostic Test: coagulation-related factors


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients with primary gastric malignant tumors, patients who underwent radical resection of gastric cancer, patients with a postoperative pathology of adenocarcinoma or signet ring cell carcinoma according to the WTO pathological classification, Exclusion Criteria: patients who have distant metastases, such as liver or lung metastases, were found on preoperative ultrasound and computed tomography (CT) examinations, patients who have received preoperative neoadjuvant chemotherapy, patients who take anticoagulant drugs (such as aspirin) prior to surgery, patients who had any previous coagulation disorder.
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| N0<br>gastric cancer patients with no lymph node metastasis | Diagnostic Test: coagulation-related factors<br>* We retrospectively evaluated the relationship between lymph node metastasis and coagulation-related factors in 516 patients with T4a stage gastric cancer.<br>|
| N+<br>gastric cancer patients with lymph node metastasis, including patients with N1, N2 and N3 stage cancer | Diagnostic Test: coagulation-related factors<br>* We retrospectively evaluated the relationship between lymph node metastasis and coagulation-related factors in 516 patients with T4a stage gastric cancer.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Preoperative coagulation-related factors (MA values) of patients | MA values(mm). Measure the data of preoperative MA values in 516 gastric cancer patients to see wether this indicator correlated with tumor stage in patients with gastric cancer. | Three years | 
| Preoperative coagulation-related factors (platelet counts) of patients | Platelet counts（x10^9/L). Measure the data of preoperative platelet counts in 516 gastric cancer patients to see wether this indicator correlated with tumor stage in patients with gastric cancer. | Three years | 
| Preoperative coagulation-related factors (fibrinogen levels) of patients | Fibrinogen levels (g/L). Measure the data of preoperative fibrinogen levels in 516 gastric cancer patients to see wether this indicator correlated with tumor stage in patients with gastric cancer. | Three years | 
| Preoperative coagulation-related factors (D-dimer) of patients | D-dimer (mg/L). Measure the data of preoperative D-dimer in 516 gastric cancer patients to see wether this indicator correlated with tumor stage in patients with gastric cancer. | Three years | 
| Postoperative pathological results of tumor T stage. | Recording the postoperative pathological tumor T stage in 516 patients with gastric cancer. | Three years | 
| Postoperative pathological results of tumor N stage. | Recording the postoperative pathological tumor N stage in 516 patients with gastric cancer. | Three years. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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gastric cancer, lymph node metastasis, maximum amplitude, prognostic factor