Effective Training in Overweight and Obese People

Study Overview
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Brief Summary
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The aim is to come to a consensus about how to prescribe exercise training that actually helps overweight and obese people. Thus, the present study determines the effects of several types of exercise training to define the one with the largest effect with the least effort.

Official Title
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Effective Training in Overweight and Obesity

Conditions
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Obesity, Overweight

Intervention / Treatment
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* Behavioral: Strength training
* Behavioral: continuous moderate-intensity aerobic training
* Behavioral: high-intensity interval aerobic training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Body mass index (BMI) over 30 Exclusion Criteria: Not able to walk on a treadmill Participating in an other study Serious cardiovascular diseases

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: strength training<br>Over a 12-week period, 13 subjects performed three programmed exercise sessions per week; two supervised by the study investigators in the research laboratory and one performed at home or in a gym, according to instructions. | Behavioral: Strength training<br>* a strength training regime of 4 series with 5 repetitions each, at approximately 90% of 1 repetition maximum (RM), in a leg press apparatus to develop maximal strength mainly from neural adaptation with minimal weight gain due to muscular hypertrophy.<br>|
| Experimental: continuous moderate-intensity aerobic training<br>Over a 12-week period, 13 subjects performed three programmed exercise sessions per week; two supervised by the study investigators in the research laboratory and one performed at home or in a gym, according to instructions. | Behavioral: continuous moderate-intensity aerobic training<br>* The moderate-intensity group walked continuously for 47 min at 60-70% of maximum heart rate (HRmax) to ensure that the training protocols were isocaloric.<br>|
| Experimental: high-intensity interval aerobic training<br>Over a 12-week period, 14 subjects performed three programmed exercise sessions per week; two supervised by the study investigators in the research laboratory and one performed at home or in a gym, according to instructions. | Behavioral: high-intensity interval aerobic training<br>* High-intensity training consisted of a 10 min warm-up period at 50-60% of HRmax [maximal HR (heart rate)], followed by 4×4-min intervals at 85-95% of HRmax with 3 min active breaks in between the intervals, consisting of walking or jogging at 50-60% of HRmax. The exercise session was terminated by a 5 min cool-down period.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Body weight |  | 12 weeks | 
| Aerobic capacity |  | 12 weeks | 
| Endothelial function |  | 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Molecular markers in fat and skeletal muscle biopsies for the effects of exercise training |  | 12 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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aerobic capacity, endothelial function, exercise