Effect of 4 Weeks of Shuttle Run Training on Insulin Sensitivity in Sedentary Men

Study Overview
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Brief Summary
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A number of studies have shown that short duration, high intensity interval training can improve health-related outcomes, such as insulin sensitivity and cardiorespiratory fitness. However, these often use specialized equipment, such as cycle ergometers, which makes it difficult to roll these interventions out for wide-scale use in the general population. This study aims evaluate the effects of a high intensity shuttle running intervention on insulin sensitivity, fitness and related cardiometabolic risk factors in men who are currently inactive. Participants will be randomized into intervention (4 weeks of shuttle running) and control groups. We hypothesize that the shuttle running programme will result in improved insulin sensitivity, fitness and increased fat oxidation at rest compared with the control group.

Official Title
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Effect of 4 Weeks of Shuttle Run Training on Insulin Sensitivity in Sedentary Men

Conditions
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Insulin Resistance, Obesity, Metabolic Syndrome

Intervention / Treatment
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* Behavioral: Exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: male 18-40 years undertaking < 1 hour per week of planned exercise Exclusion Criteria: BMI > 35 kg/m2 Blood pressure > 160/90 mm Hg (on anti-hypertensive medication) history of established coronary heart disease family history of early cardiac death (<40 years)

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Exercise<br>4 week supervised high-intensity shuttle running intervention, with 3 sessions per week (12 sessions in total) | Behavioral: Exercise<br>* 4-week supervised high intensity shuttle running intervention, 3 sessions per week (12 sessions in total)<br>|
| No Intervention: Control<br>No intervention - participants maintain usual lifestyle | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Insulin sensitivity | Assessed from glucose and insulin concentrations in fasted state and during oral glucose tolerance test. | Change from baseline immediately post-intervention (4 weeks after baseline) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Resting substrate utilization | Metabolic rate and fat and carbohydrate oxidation estimated via indirect calorimetry | Change from baseline immediately post-intervention (4 weeks after baseline) | 
| Endurance exercise performance | Time taken to complete 100 x 10m shuttle runs | Change from baseline immediately post-intervention (4 weeks after baseline) | 
| Sprint exercise performance | Time taken to complete 10 x 10m shuttle runs | Change from baseline immediately post-intervention (4 weeks after baseline) | 
| Body weight |  | Change from baseline immediately post-intervention (4 weeks after baseline) | 
| Waist circumference |  | Change from baseline immediately post-intervention (4 weeks after baseline) | 
| Percentage body fat |  | Change from baseline immediately post-intervention (4 weeks after baseline) | 
| Clustered Cardiometabolic Risk Score | Clustered Cardiometabolic Risk Score = -zHDL+zInsulin+zGlucose+zTriglycerides+( zBMI+zWC)/2+(zSBP+zDBP)/2. | Change from baseline immediately post-intervention (4 weeks after baseline) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Physical activity, Exercise, Insulin resistance, High intensity interval training, Fat oxidation, Fitness, Lipids, Blood pressure