Measuring Consequences of Disability for Patients With Multiple Sclerosis and Caregivers on Economic Burden

Study Overview
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Brief Summary
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The objective of this study is to measure economic burden of Multiple Sclerosis (MS) from a new point of view that includes consequences of disability on Quality Of Life (QOL), social participation and capabilities of patients and caregivers. To the investigators' knowledge, there is currently no data including intangible costs related to caregivers and calculating the overall economic cost of Multiple Sclerosis, particularly, in France.

Detailed Description
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The goal of this study is to evaluate prospectively the economic burden of Multiple Sclerosis (MS) in France by calculating direct costs (medical and non-medical) and indirect costs and by estimating consequences of MS on utility (QALY) of patients and caregivers in a societal perspective.

Official Title
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Measuring Consequences of Disability for Patients With Multiple Sclerosis and Caregivers on Economic Burden and Social Participation.

Conditions
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Multiple Sclerosis, Physical Disability, Economic Burden, Social Interaction, Capability, Quality of Life

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Participant aged 18 or more Confirmed MS diagnosis (McDonald 2005) Defined type of MS according classification of Lublin and Reingold Exclusion Criteria: Subject living in an institution Severe cognitive dysfunction preventing to answer questionnaire Subject already included in other clinical study (phase 1 to 3)

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Annual average total health care cost of the Multiple Sclerosis by patient | Global cost of Multiple Sclerosis considering direct medical and non-medical costs as well as the indirect and intangible costs associated to the patient-caregiver | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Score of social participation | Correlation between the score of social participation and health care costs of the disease will be determined | 1 year | 
| Validity of life quality measurement EQ-5D | The EQ-5D index is a generic measure of health status that provides a simple descriptive profile and a single index value that can be used in the clinical and economic evaluation of health care | 1 year | 
| Utilities measured by the Short Form-6D (SF-6D) | The SF-6D is a utility index based on a descriptive system composed of 11 items from six dimensions of the SF-36: physical functioning, role limitations, social functioning, pain, mental functioning and vitality. | 1 year | 
| QALY | Health related quality in life will be measured as Quality adjusted life years (QALY) | 1 year |