Epidemiology of Barrett's Esophagus: A Population Based Study

Study Overview
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Brief Summary
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To assess attitudes toward screening for esophageal adenocarcinoma (EAC) and Barrett's esophagus (BE) in the community. To develop a population based clinical risk factor prediction model for the diagnosis of BE and identify novel risk factors for BE which would make population based screening more efficient. This will be an important first step in identifying the target population for BE screening, another crucial component of making screening feasible and efficient

Official Title
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Epidemiology of Barrett's Esophagus: A Population Based Study

Conditions
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Barrett's Esophagus, Gastroesophageal Reflux Disease (GERD), Olmsted County Resident

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Case: Olmsted county residents > 18 years old from the barrett's esophagus (BE) incidence cohort who are still alive at the time of study. Control # 1 : Olmsted county residents > 18 years old that responded to a recent community based survey and reported gastroesophageal reflux (GER) symptoms at least once a week and without a known diagnosis of BE. Control # 2 : Olmsted county residents > 18 years old that responded to a recent community based survey that did not report any GER symptoms and without a known diagnosis of BE. Exclusion Criteria: Cases: BE subjects who Have died prior to the start of this study; Refuse to participate; Controls: respondents to the constipation survey who Are known to have BE; Have died prior to the start of this study; Refuse to participate; -

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 95 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| with gastroesophageal reflux disease(GERD)<br>Subjects with gastroesophageal reflux disease (GERD) | |
| Non-GERD<br>Subjects with no history of gastroesophageal reflux disease (GERD) | |
| Barrett's esophagus<br>Subjects with confirmed barrett's esophagus in Olmsted county | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The primary outcome from the survey will be the proportion of patients willing to undergo an esophageal capsule study compared to those willing to undergo an endoscopic procedure (Esophagogastroduodenoscopy or transnasal endoscopy) |  | 18 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Study established (age, gender, ethnicity, reflux) and potential risk factors (sleep apnea, visceral adiposity, Helicobacter pylori infection, Metabolic Syndrome)to develop a clinical risk factor model for diagnosis of Barrett's esophagus(BE). | Metabolic Syndrome (ATP III criteria, JAMA 2001; 285: 2486-97.) defined as a combination of clinical disorders that includes the presence of three or more of the following indicators: abdominal obesity (waist circumference > 102 cm in men, > 88 cm in women); high triglyceride level (≥ 150 mg/dL); low level of high density lipoprotein (< 40 mg/dL in men; < 50 mg/dL in women); high blood pressure (≥ 130/85 mmHg); high fasting plasma glucose (≥ 110 mg/dL). | 18 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Barrett's esophagus, gastroesophageal reflux disease, GERD