Cornea Ectasia Excimer Laser Treatment

Study Overview
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Brief Summary
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To evaluate efficacy, safety, objective and subjective quality of vision after treatment of cornea ectasia with transepithelial topographic guided laser simultaneous Central Corneal Remodeling (CCR) and Cross-linking (CXL).

Detailed Description
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Background To evaluate efficacy, safety, objective and subjective quality of vision after treatment of cornea ectasia performed with transepithelial topographic guided laser simultaneous Central Corneal Remodeling (CCR) and Cross-linking (CXL). Methods In this retrospective study 8 eyes of 8 patients (mean age 31.50±14.73 years) affected by cornea ectasia underwent simultaneous CCR and CXL. Preoperative and 6 month postoperative uncorrected distance visual acuity (UDVC) and distance corrected visual acuity (DCVA) were measured using the Efficacy and Safety index. Objective and subjective quality of vision were evaluated preoperatively and 6 months postoperatively using corneal morphological irregularity index (CMI), National Eye Institute Visual Function NEI-VFQ25 and NEI-VFQ39 questionnaires.

Official Title
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Combined Technique of Corneal Remodeling to Treat Ectasia

Conditions
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Corneal Ectasia

Intervention / Treatment
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* Procedure: topographic guided trans epithelial excimer laser


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: - keratoconus with moderate severity (Amsler-Krumeich stage I-II) Exclusion Criteria: concomitant ocular disease concomitant systemic disease corneal opacities

Ages Eligible for Study
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Minimum Age: 19 Years
Maximum Age: 66 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: topographic guided trans epithelial excimer laser|In this retrospective study 8 eyes affected by cornea ectasia of 8 patients (mean age 31.50±14.73 years) underwent simultaneous CCR and CXL. Preoperative and 6 month postoperative uncorrected distance visual acuity (UDVC) and distance corrected visual acuity (DCVA) were measured using the Efficacy and Safety index. Objective and subjective quality of vision were respectively evaluated through preoperative and 6 month postoperative corneal morphological irregularity index (CMI), National Eye Institute Visual Function NEI-VFQ25 and NEI-VFQ39 questionnaires.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| quality of vision | uncorrected distance visual acuity (UDVC), distance corrected visual acuity (DCVA) | preoperatively | 
| quality of vision | Efficacy and Safety index. | preoperatively | 
| quality of vision | corneal morphological irregularity index (CMI) | preoperatively | 
| quality of vision | uncorrected distance visual acuity (UDVC), distance corrected visual acuity (DCVA) | 6 months postoperatively | 
| quality of vision | Efficacy and Safety index. | 6 months postoperatively | 
| quality of vision | corneal morphological irregularity index (CMI) | 6 months postoperatively |