Effect of Glucosamine or Ibuprofen Combined With Physical Training in Patients With Knee-Osteoarthritis

Study Overview
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Brief Summary
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The investigators will investigate the effect of glucosamine or ibuprofen combined with 12 weeks of muscle strength-training in patients with knee-osteoarthritis. The investigators would like to elucidate whether treatment with glucosamine or NSAID interact with the effects of exercise in osteoarthritis patients.

Official Title
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Effect of Glucosamine or Ibuprofen Combined With Physical Training in Patients With Knee-Osteoarthritis

Conditions
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Osteoarthritis of the Knee

Intervention / Treatment
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* Drug: glucosamine sulphate
* Drug: ibuprofen
* Drug: placebo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 50 to 70 years Bilateral tibiofemoral osteoarthritis of the knee on x-ray American College of Rheumatology (ACR) clinical classification criteria Exclusion Criteria: Severe health problems such as cardiovascular disease, active cancer, diabetes, kidney or liver diseases Excess alcohol use (> 21 alcoholic drinks per week) Severe overweight (BMI > 35) History of injury or operation in the knee, planned knee-joint replacement, other rheumatologic diseases, previous gastric ulcer, allergy to the contents of ibuprofen or glucosamine, regular strength training prior to the inclusion

Ages Eligible for Study
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Minimum Age: 50 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Glucosamine<br> | Drug: glucosamine sulphate<br>* Subjects are administered glucosamine-sulphate tablets of 500 mg * 3 daily, while they are performing a strength-training program with both legs (*3 weekly) for 12 weeks.<br>* Other names: glucosamine from Ferrosan;|
| Experimental: Ibuprofen<br> | Drug: ibuprofen<br>* Subjects are administered 600 mg * 2 daily, while they are performing a strength-training program with both legs (*3 weekly) for 12 weeks<br>* Other names: Ibumetin from Nycomed (vnr:38 83 71);|
| Placebo Comparator: Placebo<br> | Drug: placebo<br>* Subjects are administered placebo tablets, while they are performing a strength-training program (*3 weekly) with both legs for 12 weeks<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| muscle strength and hypertrophy |  | We measure before and after 12-weeks strength training. | 
| cartilage biomarkers |  | We measure before and after 12 weeks strength training | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| muscle regeneration and function |  | We measure before and after 12-weeks strength training. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Knee Osteoarthritis, exercise, strength training, Glucosamine, Dietary supplement, Ibuprofen, NSAID