Alveolar Macrophage Proteomics in HIV-associated Emphysema

Study Overview
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Brief Summary
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This study is being done to examine lung function changes in individuals with HIV infection and to understand why individuals with HIV have increased risk of lung damage from cigarette smoking.

Detailed Description
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To delineate the natural history of HIV associated emphysema in the HAART era. To compare the alveolar macrophage proteomes from HIV-seropositive smokers with emphysema to the alveolar macrophages proteomes of both HIV+ smokers without emphysema and HIV- smokers. To establish whether coinfection with HIV and Hepatitis C results in accelerated lung disease manifested by decrements in forced expiratory volume and carbon monoxide diffusing capacity.

Official Title
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Alveolar Macrophage Proteomics in HIV-associated Emphysema

Conditions
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HIV, Emphysema, HIV Infections

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Clinically stable HIV-seropositive (and HIV-seronegative) individuals Ages 18 years and older Female subjects on no oral contraception with a negative pregnancy test Subjects capable of giving written consent Exclusion Criteria: Known medical illness that would preclude bronchoscopy/BAL (e.g. unstable angina, new cardiac arrhythmia). This only pertains to subjects involved in the bronchoscopy phase of the study. Pregnant females Prisoners

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>Alveolar macrophage proteomes from HIV-seropositive smokers with emphysema | |
| 2<br>Alveolar macrophages proteomes of both HIV+ smokers without emphysema and HIV- smokers. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| examine the natural history of smoking related lung damage in patients with HIV | HIV-Seropositive individuals are at increased risk of developing pulmonary emphysema (1,2). With improved therapy for HIV, and increased life expectancy in this population with a high smoking prevalence, chronic obstructive pulmonary disease (COPD) may assume an increasingly important role with respect to health related quality of life and medical complications. This research will provide a unique opportunity to examine the natural history of smoking related lung damage in patients with HIV infection. In addition, this research will involve sampling of lung cells to determine if there are unique proteins present that may be related to the increased risk of emphysema in this population. This may shed important insight into how the lung responds to injury and how it repairs itself. If critical proteins can be identified, treatment strategies may eventually be developed to either decrease proteins causing injury or increase protective proteins. | 3 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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lung damage, cigarette smoking, HIV-seropositive, emphysema