PRP in 2ry Spontaneous Pneumothorax

Study Overview
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Brief Summary
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secondary spontaneous pneumothorax patients will be enrolled ,all of them will receive PRP with different doses and schedules

Official Title
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Platelet Rich Plasma in Secondary Spontaneous Pneumothorax

Conditions
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Pneumothorax Spontaneous Secondary

Intervention / Treatment
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* Biological: Platelet Rich Plasma


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: COPD patients developed spontanous pneumothorax and was managed with intercostal tube insertion Exclusion Criteria: refusal of participation

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Platelet rich plasma group<br> | Biological: Platelet Rich Plasma<br>* Application of platelet rich plasma through the intercostal tube into the pleural space<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Air leak assessment by Cerfolio classification of the air leak by single observer | Continuous:Air leak is Present throughout the respiratory cycle Inspiratory : Present during the inspiration phase of the respiratory cycle. Expiratory: Present only during the expiratory phase of the respiratory cycle Forced expiration: Present only when the patient coughs or forces exhalation | within 10 days after application of platelet rich plasma | 
| physician assessment of complete lung inflation by absence of signs of pneumothorax in chest x ray done to the patient during hospital stay | no Chest x ray signs of pneumothorax i.e no jet balck translucency or border of collapsed lung) by physician interpretation | within 10 days after application of platelet rich plasma | 
| recurrence of pneumothorax by physician interpretation of Chest x ray done to the patient in follow up visit i.e detecting jet balck translucency or border of collapsed lung | no Chest x ray signs of pneumothorax i.e no jet balck translucency or border of collapsed lung) by physician interpretation | one month after removal of intercostal tube | 
| recurrence of pneumothorax by physician interpretation of Chest x ray done to the patient in follow up visit i.e detecting jet balck translucency or border of collapsed lung | no Chest x ray signs of pneumothorax i.e no jet balck translucency or border of collapsed lung) by physician interpretation | two months after removal of intercostal tube | 
| recurrence of pneumothorax by physician interpretation of Chest x ray done to the patient in follow up visit i.e detecting jet balck translucency or border of collapsed lung | no Chest x ray signs of pneumothorax i.e no jet balck translucency or border of collapsed lung) by physician interpretation | three months after removal of intercostal tube | 
| recurrence of pneumothorax by physician interpretation of Chest x ray done to the patient in follow up visit i.e detecting jet balck translucency or border of collapsed lung | no Chest x ray signs of pneumothorax i.e no jet balck translucency or border of collapsed lung) by physician interpretation | six months after removal of intercostal tube |