Early Detection and Screening Strategy of Gatric Cancer in Sichuan Province-A Prospective Cohort Study (WCH-GC-SIGES-01)

Study Overview
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Brief Summary
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To establish prospective cohort of healthy population and corresponding serum sample bank in Sichuan province to provide platform for exploring early diagnosis and screening strategy of gastric cancer by a prospective cohort study.

Detailed Description
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H. pylori was one of the most important carcinogenic factor for gastric cancer and play a crucial role in inducing gastritis, atrophy and canceration. Chronic atrophic gastritis (CAG) was a common precancerous disease, people with CAG become high-risk population and need regular follow-up. However, study about occurrence risk prediction for gastric cancer when H. pylori infection concurrence with CAG was still spare. In especial, there was still no population screening program based on serology. The relative clinical epidemiology for providing evidence for China gastric cancer screening program was very rare. This study aim to evaluate gastric cancer occurrence risk and diagnostic value of people combined with H. pylori infection and CAG by Serological methods in Sichuan province China. We also project to design optimized screening program suitable for people in sichuan province China.

Official Title
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A Prospective Cohort Study of Early Detection and Screening Strategy for Gatric Cancer in Sichuan Province China (SIGES-01)

Conditions
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Neoplasm, Stomach, H. Pylori Infection, Chronic Atrophic Gastritis

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Inhabitant in Sichuan province in China (length of residence > 10 years); Complete physical examination in our hospital, the outcomes was asymptomatic and cancer free healthy individuals; Age between 20 and 70; With normal cognitive and communication ability; Without gastroscopy during recruitment, physical examination item including gastroscopy enrolled in prospective cohort study; Wiling to accept 1-2 times routine physical examination in our hospital; Agree to accept the follow-up of our project group; Exclusion Criteria: With history of malignant tumor; Refuse to donate blood specimen; With serious comorbidity and/or finite life (less than 5 years); Request to retreat from this study;

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The number of new cases of gastric carcinoma | The new cases of gastric and other epidermal malignant tumor | 5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time of finding nee cases | The time during SIGES when finding nee gastric cancer and relative disease | 5 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Gastric carcinoma, Early diagnosis, screening stragety, health population cohort