Thromboelastogram in Postdelivery Preeclamptic Patients

Study Overview
=================
Brief Summary
-----------------
There are no studies evaluating the effect of aging on hemostasis of preeclamptic patients. Additionally, although there are some studies that establish normal reference values for TEG profiles in healthy term pregnant patients, conflicting results have been found in preeclampsia. Reference values are important to establish baseline parameters in cases of pre-eclampsia complicated by postpartum hemorrhage. The investigators will evaluate reference values for TEG in postdelivery preeclamptic patients and the difference between vaginal delivery and cesarean section.

Detailed Description
-----------------
After approval by the Institutional Review Board and informed consent from participants, the investigators are obtaining blood samples for TEG processing, from pregnant patients admitted to the maternity unit of Augusta University Medical Center. Patients are being classified in 2 groups: term pregnant patients with diagnosis of pre-eclampsia who undergo cesarean section and those having spontaneous vaginal delivery. Each group will be divided into subgroups according to maternal age: 18-25 years, 26-35 years, >36 years. Pre-eclampsia is defined and classified according to the definitions of the American College of Obstetricians and Gynecologists published in 2013.

Official Title
-----------------
Effect of Age on Reference Values for Thromboelastography in Pregnant Women With Pre-eclampsia

Conditions
-----------------
Coagulation Disorder, Preeclampsia, Pregnancy Complications

Intervention / Treatment
-----------------
* Diagnostic Test: Thromboelastogram


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age > 18 years Mental competence Gestational age > 37-week Informed consent Diagnosis of preeclampsia (with or without features of severity) Exclusion Criteria: Gestational age < 37-week Known bleeding or thrombotic diathesis Use of aspirin or unfractionated or low-molecular weight heparin within the last 48 hours BMI > 35 Maternal comorbid conditions other than preeclampsia

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Post-cesarean preeclampsia<br> | Diagnostic Test: Thromboelastogram<br>* Blood sample processing for thromboelastogram<br>|
| Post spontaneous vaginal delivery preeclampsia<br> | Diagnostic Test: Thromboelastogram<br>* Blood sample processing for thromboelastogram<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| R time | Reaction time of whole blood | 10 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| K time | Activation time | 10 minutes | 
| Maximum amplitude | Amplitude in relation to platelet count and function | 10 minutes | 
| LY-30 | Lysis at 30 minutes | 30 minutes |