Glucose as a Mediator of Self-control Performances in Patients With Schizophrenia

Study Overview
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Brief Summary
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The research aims to investigate the relationship between self-control ability and blood glucose level in schizophrenic patients. The main purpose of the present study is to explore whether the close relationship of blood glucose and self-regulatory strength observed in healthy individuals, is applicable to schizophrenic patients. More specifically, the current study aims to investigate whether the exertion of self-control reduces blood glucose, to examine whether low level of blood glucose deteriorates subsequent self-control performances to examine whether restoring the glucose level eliminates these impairments, in schizophrenic patients.

Official Title
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Glucose as a Mediator of Self-control Performances in Patients With Schizophrenia: A Randomized Controlled Study

Conditions
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Schizophrenia

Intervention / Treatment
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* Dietary Supplement: glucose drink


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Aged 15 or above DSM-IV diagnosis of schizophrenia, schizoaffective disorder, schizophreniform psychosis, brief psychosis, psychosis NOS or delusional disorder Cantonese-speaking Chinese Ability to understand the nature of the study and sign informed consent Exclusion Criteria: Organic Brain disorder Known history of intellectual disability Priority Follow Up (Subtarget or Target) All allergic to any sugar or artificial sweeteners Diabetics Physical Disability

Ages Eligible for Study
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Minimum Age: 15 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Glucose & Depleting<br>participants will perform in a depleting task and receive a glucose drink | Dietary Supplement: glucose drink<br>* participants will receive a drink rich in glucose<br>|
| Placebo Comparator: Glucose & non-depleting<br>participants will perform in a non-depleting task and receive a glucose drink | Dietary Supplement: glucose drink<br>* participants will receive a drink rich in glucose<br>|
| No Intervention: Placebo & depleting<br>participants will perform in a depleting task and receive a placebo drink | |
| No Intervention: Placebo & non depleting<br>participants will perform in a non depleting task and receive a placebo drink | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood Glucose Level |  | baseline, after depleting task | 
| self control tasks (handgrip, stroop, figure tracing task) |  | after 12-minutes metabolizing phase | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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schizophrenia, Psychotic Disorders, Psychoses