The Effect of Non Invasive Brain Stimulation on Impulsivity in Borderline Personality Disorder

Study Overview
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Brief Summary
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A pilot study to examine the effects of Non-Invasive Brain stimulation on impulsive behaviour in patients diagnosed with Borderline Personality Disorder. patients who received the neurostimulation sessions will be enrolled in short term psychotherapy (3-month)

Official Title
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Effects of Transcranial Direct Current Stimulation in Conjugation With Psychotherapy on Impulsivity in Patients With Borderline Personality Disorder

Conditions
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Borderline Personality Disorder

Intervention / Treatment
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* Device: NeuroConn


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria Clinical Diagnosis of Borderline Personality Disorder (DSM-V) Resident of Great Montreal Ability to make decision Clinical score is equal or more than 17 in Borderline Personality Disorder Severity Index (BPDSI) resident of greater Montreal Area, Exclusion Criteria: material Metal in the brain History of seizure or epilepsy severe scalp irritation or eczema recent scares, cut wounds, tattoo on the scalp severe substance use disorder clinical diagnosis of severe mood disorders o Active psychotic episode Pregnancy

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Interventional Model Description: we recruited 10 patients who attended a 10-session of tDCS stimulation. Each session lasted for 20 minutes in a 2-week.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Patients with BPD assigned to the trial of 10 active tDCS sessions followed by psychotherapy<br>Patients diagnosed with Borderline Personality disorder and BPDSI score is > or = 17 will be assigned for active tDCS session (NeuroConn, Germany) candidates will have 20-minute session per day for 10 weekdays in 2 weeks. Then they will attend short term psychotherapy session for 3 months. | Device: NeuroConn<br>* A neurostimulation decivse that works be generating weak electric current via Electrodes. These electrodes placed on a specific cerebral location, where the defect assumed to be there) to modulate the neuronal activity. This neuronal modulation does not induce or fire action potential but it facilitate action potentials and cerebral interconnection as well corticolimbic connection)<br>* Other names: transcranial Direct Current Stimulation;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The effect of NIBS on impulsivity (UPPS- Behavioral Impulsive scale) | Patients with BPD will complete UPPS impulsive behavioral scale, a self reported questionnaire, before the first tDCS session and after they complete the 10 sessions of tDCS sessions. this questionnaire consists of 45 questions with 4 likert scale range for each question. The questionnaire is divided into 4 subscales: Urgency, lack of premeditation, lack of perseverance, sensation seeking. | 2-week stimulation session | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The effect of tDCS on BPD severity overall ( Borderline Personality Disorder Severity Index: BPDSI) | The BPD patients who attend the tDCS sessions and the short-term psychotherapy will be evaluated by one psychiatric with a semi-structured interview evaluation, Borderline Personality disorder Severity Index (BPDSI) | 3 months | 
| The Effect of tDCS on Risk taking ( an impulsive behavior dimension) | a computerized measure of risk taking behavior. Each participant will have a set of 30 balloons with temporary and permanent bank. The possibility of balloon explosion increased each time the participant inflate ( click on the balloon) while the amount of money increased by 0.5 euro with each inflation. the participant could more the earned money from inflation anytime before unexpected balloon explosion to the permanent bank. The total number of the pumps will determine the probability of risk taking behavior | 2 weeks | 
| the effect of tDCS on depressive symptoms in BPD (Montgomery-Asberg Depression Rating Scale (MADRS)) | A self reported questionnaire that assess the depressive symptoms in the last 3 days. it consists of 9 questions with 3 likert score range ; each question examines different aspect of depression. | 2 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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impulsivity, Non-Invasive Brain Stimulation, Psychotherapy