Radiographic and Histological Evaluation of Regenerated Bone After Grafting Using Allograft Shell and Autogenous Chips

Study Overview
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Brief Summary
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The clinical cases in the present study described the khoury shell technique using an allograft plate and autogenous chips, for horizontal reconstruction of the anterior alveolar ridge in the esthetic zone. Without need to use autogenous bone graft techniques that are characterized by more aggressive surgery.

Official Title
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Evaluation of Anterior Alveolar Ridge Reconstruction With Allogenic Bone Plate and Autogenous Cortical Bone Chips: A Radiographic and Histological Clinical Study

Conditions
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Alveolar Bone Resorption

Intervention / Treatment
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* Procedure: Horizontal alveolar bone augmentation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with class IV of Cawood and Howell classification in the anterior maxilla. Males and females 18-50 years of age. Patients with adequate oral hygiene. Patients with healed sites for at least 6 months after tooth extraction. Patients with an inter-arch distance of at least 6 mm. Compliance with all requirements in the study and signing the informed consent. Exclusion Criteria: Patients with diseases of the immune system or systemic disease affecting bone healing Patients who are chronic users of medications known to affect the periodontal status. Patients with history of intravenous and/or oral bisphosphonate use. Pathologic lesions or acute infection in the area of defect. Patients who are pregnant or lactating mothers. Heavy smokers who smoke more than 10 cigarettes a day. Patients with poor oral hygiene that are not amenable to motivation and improvement. Patients with history of irradiation of the head and neck region. Vulnerable patients.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Interventional Model Description: Reconstruction of the localized deficient anterior maxilla using an allograft cortical bone plate, which was fixed at a distance from the alveolar ridge using two micro-screws, and the created gap between the allograft plate and the alveolar ridge was filled with autogenous cortical bone chips harvested intraorally using a bone scrapper.
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Horizontal alveolar bone augmentation|Horizontal augmentation in anterior maxilla using allograft shell and autogenous chips with no need for a second surgical site|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Alveolar Bone quantity | Alveolar bone width by millimeters using Cone Beam Computed Tomography | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Alveolar Bone quality | Histological evaluation of status of regenerated bone vitality and remodeling | 7 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Allograft, Autogenous chips, Horizontal augmentation, Khoury shell technique