Study of Speech Disorders , Voice and Swallowing in Primary Dystonia Oromandibular

Study Overview
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Brief Summary
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To better define the clinical characteristics of oromandibular dystonia, we aimed to study voice, speech and swallowing disorders in idiopathic oromandibular We planned to include consecutive patients followed in Lille Movement disorders department for idiopathic oromandibular dystonia and matched, healthy control subjects. Voice and speech disorders had to be assessed with the phonetic analysis, perceptive analysis and motor examination modules of the Batterie d'Evaluation Clinique de la Dysarthrie (Clinical Evaluation of Dysarthria), the Grade, Rough, Breathy, Asthenic, Strained scale, and a computer recording. Activities of daily living had to be assessed with the Oromandibular Dystonia Questionnaire, the Voice Handicap Index and the Deglutition Handicap Index.

Official Title
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Study of Speech Disorders , Voice and Swallowing in Primary Dystonia Oromandibular

Conditions
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Dystonia, Primary, Dysarthria, Dysphonia, Dysphagia

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Both groups: Man or woman Age > 18 years French social security French speaking: fluent Oromandibular dystonia group: Idiopathic oromandibular dystonia (focal or associated to other dystonic symptoms) Healthy controls group: Same age +/- 2 years than a patient from the oromandibular dystonia group Normal clinical examination Exclusion Criteria: Both groups: Any pathology making the orthophonic evaluation difficult Property protection regime Deprivation of liberty -Oromandibular dystonia group: Abnormal neurological examination, except dystonic features Healthy controls group: History of brain lesion Abnormal neurological examination Swallowing difficulties

Ages Eligible for Study
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Minimum Age: 8 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Oromandibular dystonia group<br>Patients with idiopathic oromandibular dystonia, either focal or associated to other dystonic features including generalized dystonia | |
| Healthy subjects<br>Healthy subjects (normal neurological examination), each being age-matched to a subjet of the oromandibular dystonia group | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| French scale Batterie d'Evaluation Clinique de la Dysarthrie (Clinical Evaluation of Dysarthria) phonetic analysis. | To describe the clinical characteristics of dysarthria in idiopathic oromandibular dystonia. Composite score (min=best=0; max=worst=151) including three subscales: phonetic production (min=worst=0; max=best=33); simple words (min=worst=0; max=best=88); complex words (min=wost=0; max=best=30). | 10 minutes at baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| French software Logiciel d'Evaluation Vocale Assistée (Computer-Assisted Voice Assessment): maximum phonation time | To describe the clinical characteristics of voice impairment in idiopathic oromandibular dystonia. Maximum phonation time was measured in seconds. | 1 minute at baseline | 
| French software Logiciel d'Evaluation Vocale Assistée (Computer-Assisted Voice Assessment): frequency variations | To describe the clinical characteristics of voice impairment in idiopathic oromandibular dystonia. Frequency variations were measured in Hz. | 1 minute at baseline | 
| French software Logiciel d'Evaluation Vocale Assistée (Computer-Assisted Voice Assessment): number of pauses. | To describe the clinical characteristics of voice impairment in idiopathic oromandibular dystonia. The number of pauses was counted. | 1 minute at baseline | 
| French software Logiciel d'Evaluation Vocale Assistée (Computer-Assisted Voice Assessment): total lecture time. | To describe the clinical characteristics of voice impairment in idiopathic oromandibular dystonia. Total lecture time was measured in seconds. | 1 minute at baseline | 
| French software Logiciel d'Evaluation Vocale Assistée (Computer-Assisted Voice Assessment): pauses duration | To describe the clinical characteristics of voice impairment in idiopathic oromandibular dystonia. Pauses duration was measured in seconds. | 1 minute at baseline | 
| French software Logiciel d'Evaluation Vocale Assistée (Computer-Assisted Voice Assessment): fundamental frequency | To describe the clinical characteristics of voice impairment in idiopathic oromandibular dystonia. Fundamental frequency was measured in Hz | 1 minute at baseline | 
| French software Logiciel d'Evaluation Vocale Assistée (Computer-Assisted Voice Assessment): repetitions. | To describe the clinical characteristics of voice impairment in idiopathic oromandibular dystonia. Repetitions were measured in seconds. | 2 minutes at baseline | 
| French software Logiciel d'Evaluation Vocale Assistée (Computer-Assisted Voice Assessment): mean vocal intensity | To describe the clinical characteristics of voice impairment in idiopathic oromandibular dystonia. Mean vocal intensity was measured in dB | 1 minute at baseline | 
| Voice handicap index | To describe impairment of daily living activities in idiopathic oromandibular (min=best=0; max=worst=120) | 10 minutes at baseline | 
| Tohara swallowing test | To describe the clinical characteristics of swallowing difficulties in idiopathic oromandibular dystonia. Min=best=0; max=worst=4 | 5 minutes at baseline | 
| Deglutition Handicap Index | To describe impairment of daily living activities in idiopathic oromandibular dystonia. Qualitative: 30 questions (possible answers: never; almost never; sometimes; often; always) | 10 minutes at baseline | 
| Oromandibular dystonia questionnaire | To describe impairment of daily living activities in idiopathic oromandibular dystonia. Qualitative: 25 questions (possible answers: never; almost never; sometimes; often; always) | 10 minutes at baseline | 
| Grade Rough Breathy Asthenic Strained scale | To describe dysphonia: from 0 (normal) to 3 (severe) | 5 minutes at baseline | 
| French scale Batterie d'Evaluation Clinique de la Dysarthrie (Clinical Evaluation of Dysarthria) phonetics characteristics | Phonetic characteristics of voice: nine items, each quoted from A (normal) to E (strongly abnormal). | 5 minutes at baseline | 
| French scale Batterie d'Evaluation Clinique de la Dysarthrie (Clinical Evaluation of Dysarthria) perceptive analysis. | To describe the clinical characteristics of dysarthria in idiopathic oromandibular dystonia. Perceptive score (min=best=0; max=worst=20) | 5 minutes at baseline |