Internet-based Cognitive Behavior Therapy (CBT) for Obsessive Compulsive Disorder (OCD)

Study Overview
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Brief Summary
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Cognitive behavior therapy (CBT) is an effective treatment for obsessive compulsive disorder (OCD) but there is a lack of properly trained CBT therapists. One possible treatment alternative is Internet-based CBT (ICBT) with minimal therapist input. The aim of this study was therefore to evaluate ICBT for OCD.

Detailed Description
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This is a randomized controlled trial with 101 participants. The control group receives support therapy on demand on the Internet.

Official Title
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Internet-based Cognitive Behavior Therapy for Obsessive Compulsive Disorder: A Randomized Controlled Trial

Conditions
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Obsessive Compulsive Disorder

Intervention / Treatment
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* Behavioral: Internet-based cognitive behavior therapy
* Behavioral: Support therapy on Internet


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Primary diagnosis of obsessive compulsive disorder (OCD) At least 18 years old Able to read and write in swedish Computer access Exclusion Criteria: other primary diagnosis substance abuse, psychosis, bipolar disorder, suicidal ideation, adjusted pharmacological treatment the last two months current psychological treatment for OCD, been treated with CBT the last two years, serious somatic disease, Y---BOCS>31 hoarding as primary OCD subtype

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Internet CBT<br>Internet-delivered CBT. Contact with therapist thru an e-mail system. 10 weeks. | Behavioral: Internet-based cognitive behavior therapy<br>* Internet-delivered CBT. Contact with therapist thru an e-mail system. 10 weeks<br>|
| Placebo Comparator: Support therapy<br>10 weeks. Therapist support contact through e-mail. | Behavioral: Support therapy on Internet<br>* Internet-delivered support therapy. Contact with therapist thru an e-mail system. 10 weeks<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from Baseline of obsessions and compulsions after 10 weeks and at 3- and 12 months after treatment. | Yale Brown Obsessive Compulsive Scale (Y-BOCS) | Two weeks before treatment, 10 weeks after treatment starts, 3 and 12 months after treatment has ended | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from Baseline of obsessions and compulsions after 10 weeks and at 3- and 12 months after treatment. | Obsessive Compulsive Scale - Revised (OCI-R) | Two days before treatment, once per week for 10 weeks after treatment starts, 3 and 12 months after treatment has ended | 
| Change from Baseline of obsessions and compulsions after 10 weeks and at 3- and 12 months after treatment. | Dimensional Obsessive Compulsive Scale (DOCS) | Two weeks before treatment, 10 weeks after treatment starts, 3 and 12 months after the treatment has ended | 
| Change from Baseline of depressive symptoms after 10 weeks and at 3- and 12 months after treatment. | Montgomery Asberg Depression Rating Scale | Two weeks before treatment, 10 weeks after treatment starts, 3 and 12 months after treatment has ended | 
| Change from Baseline of meta cognitions after 10 weeks and at 3- and 12 months after treatment. | Obsessive Beliefs Scale | Two weeks before treatment, 10 weeks after treatment starts, 3 and 12 months after treatment has ended | 
| Change from Baseline of quality of life after 10 weeks and at 3- and 12 months after treatment. | Euroqol | Two weeks before treatment, 10 weeks after treatment starts, 3 and 12 months after treatment has ended | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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CBT, OCD, Internet, Reduce symptom burden