Effects of Whey and Collagen on FFM, Muscle Strength and Wound Healing in Elderly Surgical Patients

Study Overview
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Brief Summary
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The purpose of the study is to compare the effect of whey protein and collagen on fat free mass, muscle strength, functional ability, wound healing and life quality in elderly patients undergoing elective knee- or hip surgery (defined as elective knee- or hip arthroplasty). The patients are admitted at the department of Orthopaedic Surgery at Herlev Gentofte Hospital.

Official Title
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The Effects of Whey Protein and Collagen on Fat Free Mass, Muscle Strength and Wound Healing in Elderly Patients Undergoing Elective Knee- or Hip Surgery

Conditions
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Sarcopenia, Hip Arthritis, Knee Arthritis

Intervention / Treatment
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* Dietary Supplement: Whey protein and Collagen supplementation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 65+ years Scheduled elective knee- or hip surgery Must be able to understand and speak danish Must be able to chew and swallow food with a regular consistency Must be able to consume the assigned protein supplementation Must be able to consent participation Exclusion Criteria: Vegan Demensia Critical complications to the surgery which prevents the patient from participating in the rehabilitation program Plasma-creatinin above 250 micromol/L Palliative patients Known intolerance of whey protein and/or collagen Patients with a pacemaker

Ages Eligible for Study
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Minimum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Collagen<br>Participants of this arm are going to consume 30 g of collagen peptides daily for 30 days | Dietary Supplement: Whey protein and Collagen supplementation<br>* Participants of each arm will consume 30 g daily of the assigned protein supplementation for 30 days. The protein supplementation will be given as protein powder which the participants will have to dissolve in cold drinks. During the intervention fat free mass, muscle strength, functional ability, wound healing and life quality of the participants will be monitored.<br>|
| Experimental: Whey Protein<br>Participants of this arm are going to consume 30 g of whey protein daily for 30 days | Dietary Supplement: Whey protein and Collagen supplementation<br>* Participants of each arm will consume 30 g daily of the assigned protein supplementation for 30 days. The protein supplementation will be given as protein powder which the participants will have to dissolve in cold drinks. During the intervention fat free mass, muscle strength, functional ability, wound healing and life quality of the participants will be monitored.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The difference in fat free mass | The outcome will be monitored through BIA and the development of fat free mass in the operated leg will be compared to the development of fat free mass in the non-operated leg. | Weekly for 30 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Wound healing | The amount of days until the wound is healed (defined as: the epithelium is covered without crust). This will be monitored trough pictures and assessed on a scale from 1-5 by a masked doctor. | Weekly for 30 days | 
| Redness and infection | The redness and infection around the wound assessed on a scale from 1-5 by a masked doctor through pictures. | Weekly for 30 days | 
| Handgrip strength | Handgrip strength measured by a handdynanometer (SAEHAN) in kg and percentage | Weekly for 30 days | 
| Extension strength of quadriceps femoris | Measured in amounts of repetitions of 0.5 or 1.0 kg. | Weekly for 30 days | 
| Life quality | Measured trough EuroQol-5D-5L | Weekly for 30 days | 
| Difference in functional ability (NMS) | Assessed by New mobility score | Weekly 30 days | 
| Difference in Chair stand test | Measured by amount of repetitions | Weekly for 30 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Hip Arthroplasty, Collagen, Whey protein, Knee Arthroplasty