Cardiac Function and Metabolism in Young Adults Born Premature (PET-MRI)

Study Overview
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Brief Summary
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The purpose of this research is to determine the effect of premature birth on later heart function and metabolism.

Detailed Description
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The purpose of this study is to determine the effects of premature birth on cardiac function, cardiac metabolism, and oxidative stress in a cohort of young adults born prematurely using cardiac positron emission tomography/magnetic resonance imaging and mitochondrial respiration studies.

Official Title
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Cardiac Function and Metabolism in Young Adults Born Premature

Conditions
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Infant,Premature

Intervention / Treatment
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* Procedure: Pulmonary Function Testing
* Procedure: Electrocardiogram
* Procedure: Positron Emission Tomography
* Procedure: Magnetic Resonance Imaging


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: National Lung Project Cohort only- birth weight <1500g and a gestational age <36 weeks Adults born preterm (Non-National Lung Project) only- gestational age ≤32 weeks OR birth weight ≤ 3lbs 5oz Healthy Controls only- No personal history of known cardiovascular or pulmonary disease Exclusion Criteria: Metabolic Disorders that would affect Fludeoxyglucose uptake Contraindications to positron emission tomography and/or magnetic resonance imaging Pregnancy, if a female of child-bearing potential A personal history of Type I or Type II diabetes

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Young adults born premature (some of them are registered on the National Lung Project) and Healthy Controls will undergo pulmonary function testing, cardiac positron emission tomography, and cardiac magnetic resonance imaging.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Preterm<br>Participants born premature either registered on the National Lung Project (currently in their late twenties) or not registered on the National Lung Project Cohort (current age ranges 18-35 years). All the participants in this group will undergo Pulmonary Function Testing, Electrocardiogram, Positron Emission Tomography, and Magnetic Resonance Imaging. | Procedure: Pulmonary Function Testing<br>* Subjects will undergo Spirometry and Plethysmography<br>Procedure: Electrocardiogram<br>* Subjects will undergo an electrocardiogram to ensure sinus rhythm<br>Procedure: Positron Emission Tomography<br>* Subjects will undergo positron emission tomography to detect images of the heart<br>Procedure: Magnetic Resonance Imaging<br>* Subjects will undergo positron magnetic resonance imaging to detect images of the heart<br>|
| Placebo Comparator: Term - Healthy Controls<br>Healthy individuals that were not born premature. Individuals are ages 18-35. Subjects will undergo Pulmonary Function Testing, Electrocardiogram, Positron Emission Tomography, and Magnetic Resonance Imaging. | Procedure: Pulmonary Function Testing<br>* Subjects will undergo Spirometry and Plethysmography<br>Procedure: Electrocardiogram<br>* Subjects will undergo an electrocardiogram to ensure sinus rhythm<br>Procedure: Positron Emission Tomography<br>* Subjects will undergo positron emission tomography to detect images of the heart<br>Procedure: Magnetic Resonance Imaging<br>* Subjects will undergo positron magnetic resonance imaging to detect images of the heart<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cardiac Glucose Uptake During Normoxic Rest (µg/Min) | Cardiac glucose uptake will be measured via 18F-fluorodeoxyglucose (FDG) PET-MRI. | Visit 1 (1 day) | 
| Change in Glucose Uptake From Normoxia to Hypoxia (µg/Min) | Cardiac glucose uptake will be measured via 18F-fluorodeoxyglucose (FDG) PET-MRI. | Visit 1 (1 day) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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premature adults, premature, premature lung function, premature cardiac function, MRI, PET