Outcomes of Total Arterial Coronary Artery Bypass Grafting

Study Overview
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Brief Summary
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real-life retrospective multicentric database for the analysis of the long term outcomes of total arterial CABG in comparison to saphenous vein based CABG

Detailed Description
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This aim of this registry is to create a multi centric database for the analysis of basic long term outcomes and immediate postoperative outcomes of total arterial CABG in comparison to saphenous vein based CABG. The registry will include both on pump and off pump surgery. The registry is intended to capture the real-life picture of the CABG scenario among centers worldwide

Official Title
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Multicentric Registry Database of Total Arterial CABG

Conditions
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Coronary Artery Disease, Surgical Wound Infection

Intervention / Treatment
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* Procedure: coronary artery bypass grafting (CABG)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: elective CABG patients (on pump or off pump surgery; pedicles of skletonized internal mammary artery harvesting technique; open or endoscopic vein harvesting technique) Exclusion Criteria: urgent or emergent CABG concomitant procedures redo cases

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Total Arterial coronary CABG<br>Total Arterial revascularization | Procedure: coronary artery bypass grafting (CABG)<br>* myocardial revascularization<br>|
| Saphenous vein based CABG<br>Saphenous vein based revascularization | Procedure: coronary artery bypass grafting (CABG)<br>* myocardial revascularization<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Survival | Long term survival | data collection every year up to 5 years after operation/entry in the registry | 
| MACCEs | Major cardiac events (myocardial infarction, stroke, readmission for CHF) | data collection every year up to 5 years after operation/entry in the registry | 
| target vessel revascularization | readmission for revascularization due to graft failure | data collection every year up to 5 years after operation/entry in the registry | 
| Wound infection | Readmission for wound infection (superficial sternal wound infection, deep sternal wound infection, saphenous vein related wound infection, need for VAC therapy, need for surgical debridment, need for prolonged antibiotic therapy) | data collection every year up to 5 years after operation/entry in the registry | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood product usage | unit of concentrated red cells, fresh frozen plasma, platelets | perioperative (in hospital) | 
| Bleeding | surgical bleeding requiring re-exploration | perioperative (in hospital) | 
| Length of ICU stay | number of days in ICU | perioperative (in hospital) | 
| Length of hospital stay | number of days in hospital | perioperative (in hospital) | 
| Duration of ventilation | number of hours ventilated | perioperative (in hospital) | 
| Cardiac complication | prolonged inotropic support (more than 48 hrs), IABP, ECMO | perioperative (in hospital) | 
| Respiratory complications | pneumonia, reintubation, pneumothorax requiring drainage, effusion requiring drainage | perioperative (in hospital) | 
| Renal complications | acute kidney injury not requiring dyalisis, dialysis | perioperative (in hospital) | 
| GI complications | mesenteric ischemia requiring surgery, ileus | perioperative (in hospital) |