Prospective Multicenter Cohort Study Evaluating the Incidence and Risk Factors for Problem Gambling Among Young Adults With First-episode Psychosis

Study Overview
=================
Brief Summary
-----------------
The aim of this observational study is to get a better understanding of the association between problem gambling psychotic disorders among young adults with firs-episode psychosis. The main questions to be answered are: What are the incidence and risk factors for problem gambling in this population? How effective are the current treatments for problem gambling in adults with first-episode psychosis? To do so, comparisons will be made among the study cohort for various factors: Use of dopamine partial agonists; Psychiatric comorbidities; Socioeconomic status; Sex; Gender; Gambling history. The nature of the treatments for problem gambling offered and received by the subjects, as well as their effectiveness, will also be documented.

Official Title
-----------------
A Better Understanding of the Association Between Problem Gambling and Psychotic Disorders in Young Adults: a New Path Towards Recovery

Conditions
-----------------
Gambling Disorder, Psychotic Disorders

Intervention / Treatment
-----------------
* Drug: Dopamine partial agonists
* Other: Psychiatric comorbidities
* Other: Sex
* Other: Gender
* Other: Socioeconomic status
* Other: Gambling history


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 18 to 35 years old; Diagnosis of first-episode psychosis (i.e., DSM-5 diagnosis of schizophrenia spectrum and other psychotic disorders, as well as DSM-5 bipolar disorder with psychotic features). Exclusion Criteria: DSM-5 diagnosis of psychotic disorder due to a medical condition; Severe intellectual disability.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| First-episode psychosis patients<br> | Drug: Dopamine partial agonists<br>* Use of antipsychotics (i.e., dopamine partial agonists vs dopamine antagonists)<br>Other: Psychiatric comorbidities<br>* Mainly substance use disorders and personality disorders<br>Other: Sex<br>* Biological sex at birth<br>Other: Gender<br>* Current gender identity<br>Other: Socioeconomic status<br>* Including main source of income, employment status, homelessness<br>Other: Gambling history<br>* History of gambling (i.e., recreational or problematic) prior to admission in the clinics<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Gambling disorder | Diagnosis of gambling disorder according to DSM-5 criteria, established by the treating psychiatrist | At baseline (i.e., at admission in the clinic) | 
| Gambling disorder | Diagnosis of gambling disorder according to DSM-5 criteria, established by the treating psychiatrist | At 6 months | 
| Gambling disorder | Diagnosis of gambling disorder according to DSM-5 criteria, established by the treating psychiatrist | At 12 months | 
| Gambling disorder | Diagnosis of gambling disorder according to DSM-5 criteria, established by the treating psychiatrist | At 18 months | 
| Gambling disorder | Diagnosis of gambling disorder according to DSM-5 criteria, established by the treating psychiatrist | At 24 months | 
| Gambling disorder | Diagnosis of gambling disorder according to DSM-5 criteria, established by the treating psychiatrist | At 30 months | 
| Gambling disorder | Diagnosis of gambling disorder according to DSM-5 criteria, established by the treating psychiatrist | At 36 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Problem gambling | Problem gambing according to a score of 8 and more on the Problem Gambling Severity Index, as questioned by the clinical case manager | At baseline (i.e., at admission in the clinic) | 
| Problem gambling | Problem gambing according to a score of 8 and more on the Problem Gambling Severity Index, as questioned by the clinical case manager | At 6 months | 
| Problem gambling | Problem gambing according to a score of 8 and more on the Problem Gambling Severity Index, as questioned by the clinical case manager | At 12 months | 
| Problem gambling | Problem gambing according to a score of 8 and more on the Problem Gambling Severity Index, as questioned by the clinical case manager | At 18 months | 
| Problem gambling | Problem gambing according to a score of 8 and more on the Problem Gambling Severity Index, as questioned by the clinical case manager | At 24 months | 
| Problem gambling | Problem gambing according to a score of 8 and more on the Problem Gambling Severity Index, as questioned by the clinical case manager | At 30 months | 
| Problem gambling | Problem gambing according to a score of 8 and more on the Problem Gambling Severity Index, as questioned by the clinical case manager | At 36 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Gambling, Psychotic disorder, Schizophrenia, Cohort, Multicenter, Prospective, Observational, Incidence, Risk factors