The Study of the Efficacy of Laser Acupuncture on Osteoarthritis Knees by Using Magnetic Resonance Imaging, Clinical Evaluation, and Movement Analysis

Study Overview
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Brief Summary
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To study the efficacy of laser acupuncture on osteoarthritis (OA) knee patients by magnetic resonance imaging (MRI), clinical evaluation and movement analysis.

Detailed Description
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The Kellgren-Lawrence (KL) grading scheme for OA knee Patient selecting flow Age: 20-70 year old Grade II-III knee OA Exlusion: Trauma history/ Space claustrophobia /Severe chronic disease/ Malignancy Pregnancy Study Cases 40 Randomize Pre-treatment MRI (to evaluate grade of OA knee/ the T2 signal of the cartilage), MRS (baseline glutamate), Movement analysis(sit to stand), Maximum strength ratio of Quadriceps/Hamstring WOMAC Post-treatment evaluation laser therapy Modality: LA-400 Treatment protocol of low level laser 40mW, 50Hz, 808nm (invisible light) , 15min The effect of laser acupuncture is dose dependent Effect of Laser Therapy on Chronic Osteoarthritis of the Knee in Older SubjectsJ Lasers Med Sci. 2016 Spring; 7(2): 112-119 830nm is an effective form of treatment for chronic knee pain caused by knee osteoarthritis. Low Level Laser Therapy for chronic knee joint pain patientsLaser Ther. 2014 Dec 27; 23(4): 273-277 Duration: 2 weeks Frequency: 3 times/week Control group: no treatment Acupuncture point: EX- LE-5, EX-EL 2, SP10

Official Title
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The Study of the Efficacy of Laser Acupuncture on Osteoarthritis Knees by Using Magnetic Resonance Imaging, Clinical Evaluation, and Movement Analysis

Conditions
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Osteoarthritis, Knee

Intervention / Treatment
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* Device: LA-400 laser acupuncture


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Kellgren-Lawrence grade II   III Exclusion Criteria: Trauma history/ Space claustrophobia/ Severe chronic disease/Malignancy Pregnancy

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: study laser group<br>laser therapy on knee for 2 weeks | Device: LA-400 laser acupuncture<br>* low level laser<br>|
| No Intervention: control group<br>no intervention | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| difference on MRI post- versus pre- treatment | compare the apparent diffusion coefficient (ADC) value post- and pre- treatment, suppose that the higher the value, the less inflammation in target tissue | 2 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Improve stability on movement analysis | Calculate the area of center of posture (COP) during the movement. Suppose that the lower value, the higher stability. | 2 weeks |