Can Sensorimotor Function Predict Graft Rupture After ACL Reconstruction

Study Overview
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Brief Summary
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In this longitudinal prospective cohort study including young people with anterior cruciate ligament (ACL) reconstruction, the investigators will evaluate if poor sensorimotor function at baseline can predict 1) graft rupture 2) the risk of contra-lateral ACL injury and 3) failure to return to sport/previous activity level within 3 years following ACL reconstruction.

Detailed Description
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In this longitudinal prospective cohort study including young athletic men and women (aged 15-35) with ACL reconstruction (ACLR), it will be investigated if poor sensorimotor function at baseline (1 year post ACLR), such as hop performance, muscle strength and postural orientation can predict 1) graft rupture 2) the risk of contra-lateral ACL injury and 3) failure to return to sport/previous activity level within 3 years following ACLR. Statistics Separate logistic regression models will be used to elucidate the influence of each muscle sensorimotor function variable on the outcomes (graft rupture, contra-lateral injury, return to sport/activity level failure), adjusted for potential confounders. With the LSI for the single-leg hop test as main outcome, power calculations show that with a re-injury rate of 7%, an estimated odds ratio of 0.95, power=80% and alpha=5 %, at least 174 individuals are needed. Based on this calculation, 200 individuals will be included for the prospective analysis, allowing for an approximate drop-out of 10%.

Official Title
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Sensorimotor Function as Predictor for Graft Rupture After Anterior Cruciate Ligament Reconstruction: A Prospective Cohort Study (STOP Graft Rupture)

Conditions
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Anterior Cruciate Ligament Injuries

Intervention / Treatment
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* Other: Different measures of muscle function such as muscle strength, hop tests, postural orientation and muscle activation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 8-16 months after ACL reconstruction With or without associated injuries to other structures of the knee (e.g., collateral ligament(s), meniscal injury) Age 15-35 years. Exclusion Criteria: ACL injury other knee and previous ACL injury index knee Diseases or disorders overriding the knee condition (e.g., neurological or rheumatological disease) Not understanding the languages of interest (any Scandinavian language or English).

Ages Eligible for Study
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Minimum Age: 15 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with ACL reconstruction in Lund and Umeå<br>Persons who have suffered a unilateral anterior cruciate ligament injury treated with reconstruction | Other: Different measures of muscle function such as muscle strength, hop tests, postural orientation and muscle activation<br>* The participants will be assessed with a physical test battery at baseline including: Isokinetic knee strength, Isometric strength of trunk and lower extremity, Single-leg hop for distance, side hop, postural orientation (single leg-squat, stair descending, forward lunge, Single-leg hop for distance, side-hop), hip and ankle range of joint motion, muscular activation pattern, 3D movement analysis and proprioception test. At follow-up (2 years), the participants will be asked to answer a survey about new ACL injuries and return to sport/previous activity level.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of participants with graft rupture | Number of patients that have sustained a rupture of the reconstructed ligament | 2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patients with contra-lateral ACL injury | Number of patients that have sustained an injur to the contra-lateral knee | 2 years | 
| Failure to return to sport/previous activity level | Number of patients that had failed to return to previous sport/activity level | 2 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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anterior cruciate ligament injury, re-injury, muscle function, functional performance, rehabilitation, physiotherapy, sensorimotor control