linjc16/ctgov huggingface dataset:
Determining the Impact of Shunting and CerebroVascular Reactivity on 7T MRI (DISCoVeR 7T MRI)

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to use transcanial doppler (TCD) ultrasound to look for possible risk factors for ischemic brain injury. We will perform contrast TCD with agitated saline contrast to identify and contrast right-to-left shunt (RLS) and breath holding to assess cerebrovascular reactivity (CVR) in the elderly.

Official Title
-----------------
A Pilot Cross-sectional Cohort Study of Right-to-left-shunt, Cerebrovascular Reactivity, Ischemic Infarct Burden on High Resolution MRI, and Cognitive Impairment in Elderly Subjects

Conditions
-----------------
Cognitive Impairment

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Males and females ≥ 60 years of age. Fluent in English. Part of the NACC longitudinal cohort (Protocol #: 068200) of the PMC/ADCC with consensus conference designation of cognitively normal, Mild Cognitive Impairment, or probable/possible Alzheimer's disease. Has consented to participate in the ADCC high-resolution MRI sub-study. NACC longitudinal visit must be within 6 months of the TCD study and brain MRI study. Women: post-menopausal or surgically sterile. Willing and able to complete all required study procedures. Completed 6 grades of education. Geriatric Depression scale less than 6 (assessed within 6 months at the NACC longitudinal visit). Exclusion Criteria: Prior clinically symptomatic ischemic or hemorrhagic stroke. Inability to tolerate or contraindication to TCD study in the opinion of an investigator or treating physician. Any medical or psychological conditions that, in the opinion of the investigator, would compromise the subject's safety or successful participation in the study.

Ages Eligible for Study
-----------------
Minimum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cognitively normal elderly<br>TCD agitated saline right-to-left shunt study TCD cerebrovascular reactivity study | |
| Cognitive impaired elderly<br>TCD agitated saline right-to-left shunt study TCD cerebrovascular reactivity study | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Presence of right-to-left shunt on TCD |  | Baseline | 
| Presence of cerebrovascular reactivity on TCD |  | Baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Volume of ischemic injury |  | Baseline | 
| Location of ischemic injury |  | Baseline | 
| Presence of cognitive impairment |  | Baseline | 
| Type of cognitive impairment |  | Baseline |
Accuracy of Noninvasive Rainbow Adhesive R1 Pulse Oximeter Sensor

Study Overview
=================
Brief Summary
-----------------
In this study, the concentration of hemoglobin will be measured using a noninvasive pulse oximeter sensor and compared with the hemoglobin value from a blood sample of the volunteer. The accuracy of a noninvasive hemoglobin sensor(s) will be assessed by comparison to hemoglobin measurements from a laboratory analyzer.

Conditions
-----------------
Healthy

Intervention / Treatment
-----------------
* Device: Rainbow Adhesive Noninvasive R1 Pulse Oximeter Sensor


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Greater than 18 years old Healthy Exclusion criteria: Do not understand the study and the risks involved Deemed ineligible by study test personnel

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: R1-25 Sensor<br>All subjects will be enrolled in the test group and will receive Rainbow Adhesive Noninvasive R1 Pulse Oximeter Sensor | Device: Rainbow Adhesive Noninvasive R1 Pulse Oximeter Sensor<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Accuracy of SpHb on R1-25 by Arms Calculation | Accuracy will be determined by comparing the noninvasive hemoglobin measurement of the pulse oximeter to the hemoglobin value obtained from a blood sample and calculating the arithmetic root mean square (Arms) error value. In order to obtain the Arms value, the blood sample hemoglobin value is subtracted from the pulse oximeter hemoglobin value for a number of samples, the average of this difference is computed as the bias. The standard deviation of the differences is computed as the precision. The square root of the sum of the squares of bias and precision is computed as the Arms Error value. | 1-5 hours per subject |
Juvenile Idiopathic Arthritis in Children in Estonia.

Study Overview
=================
Brief Summary
-----------------
Aims of the study: to study the incidence rate of juvenile idiopathic arthritis (JIA) and it's clinical subtypes in Estonia for the years 1998-2000; to examine the course and short-term clinical outcome of JIA. Method: a prospective population-based study carried on in 14 counties of Estonia

Official Title
-----------------
Juvenile Idiopathic Arthritis in Children in Estonia - an Epidemiological and Clinical Investigation.

Conditions
-----------------
Epidemiology

Intervention / Treatment
-----------------
* Other: Blood collecting for storage of samples


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: The International League of Associations for Rheumatology (ILAR) criteria for juvenile idiopathic arthritis children aged 0-15 years who had arthritis of an unknown cause for at least six weeks with an onset of the disease during the study period Exclusion Criteria: Children with infectious arthritis, postinfectious arthritis, traumatic arthritis and systemic connective tissue diseases

Ages Eligible for Study
-----------------
Minimum Age: 1 Month
Maximum Age: 15 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Subsequent new juvenile arthritis cases<br>During years 1998-2000, all new subsequent cases of juvenile idiopathic arthritis diagnosed in Estonia were included in the study group. | Other: Blood collecting for storage of samples<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mean annual incidence rate of juvenile idiopathic arthritis in Estonia during years 1998-2000. |  | 3 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
juvenile idiopathic arthritis, incidence rate
Triclosan Toothpaste and Third Molar Surgery

Study Overview
=================
Brief Summary
-----------------
Triclosan containing dentifrices are effective in the prevention of inflammatory complications following third molar surgery through reducing preoperative oral bacteria load.

Detailed Description
-----------------
This study may provide evidence on the effect of triclosan containing dentifrice on oral bacteria and oral inflammation prior to third molar surgery, and on the incidence of inflammatory complications after the surgery. If proven effective, dentifrice containing triclosan may be recommended prior to tooth extractions and replace antibiotics and other antimicrobial products as a prophylactic procedure before oral surgery procedures.

Official Title
-----------------
Effect of a Triclosan Containing Dentifrice on Oral Bacteria and Postoperative Complications Following Third Molar Surgery

Conditions
-----------------
Dry Socket, Wound Infection

Intervention / Treatment
-----------------
* Other: Colgate Total Toothpaste
* Other: Colgate Regular Toothpaste


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: must include at least one mandibular third molar with partial or full bony impaction no sign of active pericoronal (around the crown) infections must have not taken antibiotics for any reason in the past 30 days must be healthy and between 18 and 35 years of age must be able to read and sign an informed consent Exclusion Criteria: Subjects with systemic diseases and pregnant or lactating women Subjects with advanced periodontal diseases or having two or more untreated caries lesions Subjects who cannot read and sign an informed consent Subjects with signs of pericoronal infections

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Colgate Total Toothpaste|Toothbrushing with Colgate Total Toothpaste|
|Other: Colgate Regular Toothpaste|Toothbrushing with Colgate regular toothpaste|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| dry socket | Development of dry socket (alveolar osteitis) 3 to 7 days after tooth extraction | 3 to 7 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| wound infection | Development of tooth extraction wound infection 3 to 7 days after extraction | 3 to 7 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
third molars, triclosan, toothpaste, dry socket, wound infection
Bioequivalence Study Between Two Oral Formulations of Ibuprofen 800 mg Tablets Under Fasting Conditions

Study Overview
=================
Brief Summary
-----------------
Compare the rate and extent of absorption of two oral formulations of Ibuprofen 800 mg Tablets, administered as a single, one-tablet dose in fasted subjects.

Official Title
-----------------
A Randomized, Single-Dose, Two-Way Crossover Relative Bioavailability Study of Ibuprofen Tablet Formulations in Fasted Normal, Healthy Subjects

Conditions
-----------------
Bioequivalency

Intervention / Treatment
-----------------
* Drug: Ibuprofen Tablets, 800 mg


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: healthy men or women, 18 years of age or older body mass index between 19 and 30 willing to participate and sign a copy of the informed consent form Exclusion Criteria: history of allergy or hypersensitivity to ibuprofen recent history of drug or alcohol addiction or abuse pregnant or lactating women use of tobacco products within 3 months prior to study dosing evidence of a clinically significant disorder or whose laboratory results were deemed to be clinically significant receipt of any drugs as part of a research study within 30 days prior to study dosing

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Test Product<br> | Drug: Ibuprofen Tablets, 800 mg<br> <br> |
| Active Comparator: Reference Product<br> | Drug: Ibuprofen Tablets, 800 mg<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Bioequivalence was assessed on the pharmacokinetic variables Cmax, AUC,0-t, and AUC,0-infinity |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
bioequivalency, ibuprofen
Oxytocin's Effect on Social Pain Empathy

Study Overview
=================
Brief Summary
-----------------
The aim of the present experiment is to examine oxytocin's behavioral and neural effects on social pain empathy

Detailed Description
-----------------
In the current study, the investigators plan to examine whether oxytocin modulates behavior and neural activity during observing another person being excluded in an online ball-tossing game (a modified cyberball paradigm).

Official Title
-----------------
Oxytocinergic Modulation of Perceived Social Exclusion

Conditions
-----------------
Healthy

Intervention / Treatment
-----------------
* Drug: oxytocin treatment
* Drug: placebo treatment


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: healthy participants without past or current psychiatric or neurological disorders Exclusion Criteria: history of head injury medical or psychiatric illness smoking or drinking 24 hours before experiment

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 30 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: oxytocin group<br>male participants with oxytocin treatment | Drug: oxytocin treatment<br>* intranasal administration of oxytocin<br>|
| Placebo Comparator: placebo group<br>male participants with placebo treatment | Drug: placebo treatment<br>* intranasal administration of placebo<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Neural activity changes associated with oxytocin administration | fMRI-assessed brain activity during observing other being socially excluded | 45-60 minutes after drug administration | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Behavioral changes associated with oxytocin administration: ball-tossing | Number of tosses to the other players (the excluder, new player, or previously excluded player) | 45-60 minutes after drug administration | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
oxytocin, social cognition, fMRI, empathy
Prognostic Impact of Anatomical Resection Vs. Non-anatomical Resection for HCC

Study Overview
=================
Brief Summary
-----------------
Prognostic impact of AR vs NAR

Detailed Description
-----------------
Whether anatomical is better than non anatomical resection for HCC is still debated. This prospective randomized study aimed to address which approach is better in terms of patients prognosis.

Official Title
-----------------
Anatomical Liver Resection by Means of Ultrasound-guided Vessel Compression Versus Non-anatomical Resection for Hepatocellular Carcinoma: A Randomized Controlled Trial

Conditions
-----------------
Patients Affected by Hepatocellular Carcinoma, Disease-Free Survival, Overall Survival

Intervention / Treatment
-----------------
* Procedure: anatomical liver resection
* Procedure: Non-anatomical liver resection


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patient affected by single HCC patients in whom liver resection is indicated HCC without vascular invasion and/or thrombosis Exclusion Criteria: multinodular HCC metastatic disease spontaneous tumor rupture
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Anatomical resection<br> | Procedure: anatomical liver resection<br>* anatomical liver resection by means of IOUS-finger compression<br>|
| Active Comparator: Non-anatomical resection<br> | Procedure: Non-anatomical liver resection<br>* non-anatomical liver resection<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the prognostic impact of anatomical resection by means of intraoperative ultrasound (IOUS) guided vessel compression versus nonanatomical resection in terms of disease free and overall survival |  | 5-years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the impact of anatomical resection versus non-anatomical resection in terms of postoperative mortality and morbility |  | 30 and 90 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
anatomical resection, non-anatomical resection, IOUS-guided finger compression
A Comparison Study of Apadenoson and Adenosine to Treadmill Exercise Stress.

Study Overview
=================
Brief Summary
-----------------
The purpose of this clinical research study is to compare Apadenoson and adenosine to treadmill exercise stress SPECT MPI

Official Title
-----------------
A Randomized, Double-Blind Comparison of Apadenoson and Adenosine to Treadmill Exercise Stress for Single-Photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging (MPI)

Conditions
-----------------
Coronary Artery Disease

Intervention / Treatment
-----------------
* Drug: Apadenoson


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Clinically appropriate for exercise stress testing Exclusion Criteria: Contraindication to adenosine stress or inability to perform treadmill exercise test

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Apadenoson|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Agreement between MPI Summed Stress Scores for extent and severity of disease |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of imaging data to 6 month event data or angiography |  |  |
Injection of Hormone to Enhance Implantation in Embryo Transfer After IVF

Study Overview
=================
Brief Summary
-----------------
The endometrium is deprived of signals form the embryo in IVF conditions. Studies suggest that placing HCG into the uterus prior to embryo transfer can enhance implantation.

Detailed Description
-----------------
The study is in pilot phase, uncontrolled. The risks appear to be minimal and there are conflicting new reports being announced. A small amount of fluid with HCG is injected into the uterus. HCG is a potent signal to the uterus for preparation for implantation. This is not a funded study. Three published studies suggest the approach is valid; one refutes the concept.

Official Title
-----------------
Intrauterine Injection of Human Chorionic Gonadotropin to Enhance Embryo Implantation

Conditions
-----------------
Infertility

Intervention / Treatment
-----------------
* Drug: HCG is introduced


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: - infertility patients undergoing IVF with good expectation of two embryos day 3 or day 5. must speak and read English. Includes donor eggs. Exclusion Criteria:abnormal uterus -

Ages Eligible for Study
-----------------
Minimum Age: 21 Years
Maximum Age: 47 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: HCG is introduced with small catheter.<br>phase 1 non randomized pilot | Drug: HCG is introduced<br>* must have good blastocysts<br>* Other names: Improve results of IVF and embryo transfer;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| HCG enhances pregnancy rate | compare pregnancy rates to established clinical norms. | 9 months. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| implantation rate | compare implantation rate per embryo to clinical norms. | 18 months | 
| ongoing pregnancy rate | compare success to clinical norms | 22 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
IVF , embryo implantation, HCG