Chronic Arterial Disease, Quality of Life and Mortality in Chronic Kidney Injury

Study Overview
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Brief Summary
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CADKID-study is a prospective follow-up study assessing arterial disease, quality of life, mortality and their predictors in patients with severe chronic kidney disease.

Detailed Description
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Chronic kidney disease (CKD) is associated with increased risk of cardiovascular disease and mortality as well as impaired quality of life. Participants of this study all have severe CKD, defined as estimated glomerular filtration rate < 30 ml/min per 1.73 m^2. Stress ergometry, echocardiography, ultrasound assessment of arterial intima-media thickness, lateral lumbar radiograph, ECG, laboratory tests and quality of life assessment were performed at the baseline of the study and will be repeated during follow-up. Atrial fibrillation and other cardiac arrhythmias as well as pulse wave velocity measurements will be explored. Diet diaries are gathered and analysed. The aim of the study is to identify factors associated with cardiovascular disease, quality of life and mortality in this cohort.

Official Title
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Chronic Arterial Disease, Quality of Life and Mortality in Chronic Kidney Injury

Conditions
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Kidney Diseases, Cardiovascular Diseases

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: estimated glomerular filtration rate < 30 ml/min per 1.73 m^2 Exclusion Criteria: age under 18 years inability to give informed consent

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality |  | 5 years | 
| Cardiovascular morbidity |  | 5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in quality of life | Kidney Disease Quality of Life Short Form (KDQOL-SF) instrument, consisting of 20 subscales (0-100), higher score indicating better quality of life | 2 years, 5 years | 
| Number of participants with cardiac arrhythmias |  | 2 years, 5 years | 
| Rate of hospitalizations |  | 2 years, 5 years | 
| Abdominal aortic calcification (AAC) score | Scale 0-24, higher values indicate more calcification | 2 years, 5 years | 
| Carotid intima-media thickness |  | 2 years, 5 years | 
| Femoral intima-media thickness |  | 2 years, 5 years | 
| Flow-mediated dilatation of brachial artery | Dilatation at 60 seconds after the release of a cuff with pressure of 250 millimeters of mercury for 4.5 minutes, compared to at rest diameter | 2 years, 5 years | 
| Maximal bicycle stress ergometry performance | Mean work load (watts) of the last 4 minutes of exercise, higher values indicating better performance | 2 years, 5 years | 
| Left ventricular hypertrophy | Echocardiography (Interventricular septum thickness, Posterior wall thickness, Left ventricular end-diastolic diameter, Left ventricular mass index) | 2 years, 5 years | 
| Cardiac systolic function | Echocardiography (Left ventricular ejection fraction, Left ventricular global longitudinal strain) | 2 years, 5 years | 
| Cardiac diastolic function | Echocardiography (ratio of the early to late ventricular filling velocities, ratio of transmitral Doppler early filling velocity to tissue Doppler early diastolic mitral annular velocity) | 2 years, 5 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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chronic kidney disease, quality of life