Training Intensity After Coronary Bypass Grafting

Study Overview
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Brief Summary
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The purpose of this study is to investigate the effect of high and moderate intensity exercise training after coronary bypass surgery. The subjects are randomised to training at either 60-70% or 85-95% of their maximal capacity daily for four weeks. Primary outcome measure is change in maximal aerobic capacity, measured as change in maximal oxygen consumption, after the training period. Secondary outcome measures are change in quality of life, heart rate variability, ultrasound measures of the heart and blood variables, including endothelian markers.

Detailed Description
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The exercise part of cardiac rehabilitation today is often composed of low to moderate intensity training. Several studies have found interval training with high intensity to be more effective in improving physical capacity in healthy subjects and also in different patient populations. We therefore wish to compare high intensity interval training with moderate intensity training in patients operated with coronary bypass surgery. Maximal oxygen consumption is shown to be the best indicator of how many years you life, both in healthy persons and in cardiac patients. The subjects in this study is attending a four week rehabilitation program at an residential institution in Norway. They are randomised to do either a moderate or a high intensity aerobic training session each day. The hypothesis in advance, was that high intensity interval training lead to a greater improvement in maximal oxygen consumption than training with moderate intensity. We also hypothesised that there would be no difference between the two groups after 6 months, since then the patients had to administer their own exercise training.

Official Title
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Training Intensity After Coronary Bypass Grafting

Conditions
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Coronary Artery Bypass

Intervention / Treatment
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* Behavioral: Exercise training
* Behavioral: Exercise training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Coronary Artery Grafting (4-12 weeks ago) Exclusion Criteria: Not able to exercise on a treadmill Left ventricle ejection fraction < 30% hemodynamic significant valve deficit (> NYHA classification II)
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: A<br>Interval exercise training with high intensity | Behavioral: Exercise training<br>* Interval exercise training with high intensity five days per week for four weeks.<br>|
| Active Comparator: B<br>Exercise training with moderate intensity | Behavioral: Exercise training<br>* Exercise training with moderate intensity, five days per week for four weeks.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Oxygen Consumption |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quality of life |  |  | 
| Pulse |  |  | 
| Blodverdier |  |  | 
| Ekkokardiografiske parametre |  |  | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Coronary Artery Bypass (E04.928.220.520.220), Exercise Test [E01.370.370.380.250], Echocardiography [E01.370.370.380.220], Quality of Life [K01.752.400.750]