SARS-CoV-2/COVID-19 Infection Among Health Care Workers

Study Overview
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Brief Summary
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The present study finds opportunities and justifications, taking into consideration that the nature of professional practice in health needs scientific evidence resulting from systematic and systemic studies to strengthen the basis for the decisions made to have an impact on various levels, from the patient to health management itself. In addition, Cabo Verdean authorities may benefit from new evidence obtained by this study. It intends, in a growing number of health professionals exposed or infected with SARS-CoV-2, in the different health structures of the country, to contribute to substantiate a better perception of the problem and the required solutions. Therefore, assessing the potential risk factors for SARS-CoV-2 infection among healthcare workers will be essential to characterize virus transmission, preventing future infections in them and providing the associated healthcare. Due to the advances and important changes described, questions arise that guide this research and allow us to identify the problem.

Detailed Description
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The problem is stated in the following starting questions: What conditions and factors are associated with infection and non-infection by SARS-CoV-2 among health professionals working in the three hospitals on the islands of Santiago and São Vicente? Which are they (gender, age group, profession, type of contact, etc.)? Where do the infected HCW typically work (sector)? When and how did the infection occur? What is the prevalence of SARS-CoV-2 antibody in professionals with confirmed SARS-CoV-2 infection and in HCW that thought they were not infected by SARS-CoV-2? How long do anti-SARS-CoV-2 antibodies last? What is the impact of infection on unplanned absenteeism? Which symptoms and complaints (if any) persists after SARS-CoV-2 infection?

Official Title
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Associated Factors in the Transmission and Dynamics of SARS-CoV-2 Infection Among Health Care Workers in Hospitals on the Islands of Santiago and São Vicente in Cabo Verde

Conditions
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SARS-CoV-2, BCG, Health Care Worker, COVID-19

Intervention / Treatment
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* Other: Questionaire


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Being a healthcare professional working in one of the hospitals where the study will take place Be aged ≥18 years; Cases: SARS-CoV-2 infection confirmed by PCR test and/or Rapid Antigen Test; Control: No evidence and/or record of past infection with SARS-CoV-2. Exclusion Criteria: Case: Confirmation of diagnosis test for SARS-CoV-2 without indication of specimen collection date. Control: Suspected SARS-CoV-2 infection.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cohort<br>All Health Care Worker (HCW) from Hospital in Santiago and S. Vicente islands, Cabo Verde | |
| Control<br>HCW who report no SARS-CoV-2 infection in the period prior to the interview and/or suspected COVID-19 in the period prior to the interview | Other: Questionaire<br>* A questionnaire will be administered to all participants to evaluate exposures related to infection at the baseline (enrollement) - Baseline questionnaire. A Follow-up questionnaire to all participants will be done after 3 and 6 months. Capillary blood collection, for diagnosis of anti-SARS-CoV-2 Antibodies by rapid test, will be done at the first interview, for all participants (cases and controls). Collection of peripheral venous blood, for analysis of the presence and duration of anti-SARS-CoV-2 Antibodies (N and S) will be done at the first interview, and after 6 months for all participants (cases and controls).<br>* Other names: SARS-CoV-2 Serology (ELISA Test);|
| Cases<br>HCW who report positive SARS-CoV-2 infection confirmed by performing a positive PCR test and/or positive Rapid Antigen Test in the period prior to the interview | Other: Questionaire<br>* A questionnaire will be administered to all participants to evaluate exposures related to infection at the baseline (enrollement) - Baseline questionnaire. A Follow-up questionnaire to all participants will be done after 3 and 6 months. Capillary blood collection, for diagnosis of anti-SARS-CoV-2 Antibodies by rapid test, will be done at the first interview, for all participants (cases and controls). Collection of peripheral venous blood, for analysis of the presence and duration of anti-SARS-CoV-2 Antibodies (N and S) will be done at the first interview, and after 6 months for all participants (cases and controls).<br>* Other names: SARS-CoV-2 Serology (ELISA Test);|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Total number of days absent from work due to COVID-19 | Absenteeism due to COVID-19 related symptoms | From March 2020 to March 2022 | 
| Unplanned Absenteeism | Unplanned absenteeism following SARS-CoV-2 infection | 6 months after inclusion | 
| Symptomatology after infection by SARS-CoV-2 | If have or not any symptomes after SARS-CoV-2 infection | 6 months after inclusion | 
| Presence or absence of anti-SARS-CoV-2 Acs | Presence or not of anti-SARS-CoV-2 Anti-N and anti-S | 6 months after inclusion | 
| Duration of anti-SARS-CoV-2 Acs | Time of duration of anti-SARS-CoV-2 Anti-N and anti-S | After infection |