Predictive Role of Red Cell Distribution Width in Upper GI Bleeding Patients

Study Overview
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Brief Summary
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Acute upper-gastrointestinal bleeding (UGIB) is a commonly encountered cause of admission in emergency department (ED). Early risk stratification allows appropriate therapy that may be helpful to advance the patient's morbidity and mortality. Investigators hypothesized that early RDW levels may have an independent, linear relationship with recurrent or massive bleeding in UGIB patients.

Detailed Description
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This is a retrospective clinical study including the UGI patients in ED. All data will be collected through the electrical medical records. The major endpoints are the high risk patients and 30-days mortality which defined cases of including any of one among the death, re-bleeding, and received the intervention (such as blood transfusion, endoscopic therapy and operation). Investigators assessed the relationship between initial RDW level and high risk patients and 30-days mortality. In addition, investigators compare the dicrimination power for predicting outcomes between the UGIB scoring system and RDW level. Univariate and multivariate logistic regression testing and a Cox hazard regression model were used to determine the factors associated with outcome variables. In addition, investigators constructed receiver operating characteristic curves, and the areas under the curves and confidence intervals were calculated to compare the discriminatory power for outcomes.

Official Title
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Efficacy of Red Cell Distribution Width as a Predictor of High Risk and Early Mortality in Upper Gastro-intestinal Bleeding

Conditions
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Gastrointestinal Hemorrhage

Intervention / Treatment
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* Diagnostic Test: Red cell distribution widths


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age over 18 years Diagnosis as Upper gastrointestinal bleeding Check RDW when patients visited at emergency department Exclusion Criteria: Paediatrics Follow up loss Data could not be acquired

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| UGIB<br>Those who was diagnosed as UGI bleeding at emergency department during the study periods. Red cell distribution widths wers checked at all patients. | Diagnostic Test: Red cell distribution widths<br>* Measured value of Red cell distribution widths in initial laboratory result of blood cell counts at emergency department<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| High risk | Case of the death or re-bleeding, or blood transfusion or endoscopic therapy or operation. | 30 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Red cell Distribution Width, Risk, Mortality, Hemorrhage