Comparision of Two Different Feeding Method in Preterms

Study Overview
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Brief Summary
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achievement of optimal postnatal growth by adequate enteral nutrition in critically ill preterm infants is a challenge of NICU. signs like abdominal distension, reflux, vomiting, nec is a factors of discontinuing fedding in preterm. this factors plays a role in decisions about which method of gavage feeding is adopted. we compare two different feeding method to achive less fedding tolerence.

Detailed Description
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<1750 gr, <33 gw infants will enroll study. exckusion criteria: major congenital anomalies major gis anomalies The study infants are enrolled within 24 hours of birth and sequently randomized to either intermitten feeding (IF) and bolus feeding (BF). Intermittent feeding is defined as delivering enteral nutrition and generally giving 60 min and 2 hours no feeding. this circle repeats 8 times in 24 hours. Bolus feeding is the amount of nutrition put into the syringe was kept 10 cm above the baby and the fluidity was obtained by gravity through the orogastric tube. The data of the patients such as feeding intolerance (gastric residual volume more than %50 of the previous feeding volume, gastric regurgitation, abdominal distension and/or emesis ), whether there is a week-by-week feeding intolerance were noted, NEC, time to reached birth weight, time to achieved full enteral feeding, every 5 minutes during feeding, saturation, respiratory rate and heart rates will record.

Official Title
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Comparision of Two Different Feeding Method in Preterm Infants

Conditions
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Enteral Feeding Intolerance

Intervention / Treatment
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* Other: bolus/intermittant feeding


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: <1750 gr preterm infants <33 gw admitted to our nicu in first day of life Exclusion Criteria: major congenital anomalies gis anomalies septic shock exitus in 3 days of life -

Ages Eligible for Study
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Minimum Age: 1 Day
Maximum Age: 3 Days

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Sequential Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: bolus feeding group<br>In bolus feednig group preterm fed by via gravity drip over a short period, usually 15-20 min. it administrated 8-12 times daily | Other: bolus/intermittant feeding<br>* sequential randomization<br>|
| Other: intermittant feeding group<br>Intermittant feeding is delivered over a 30-60 min by infusion pump. it administrated 8-12 times daily | Other: bolus/intermittant feeding<br>* sequential randomization<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| rate of feeding intolerence | The effect of two different gavage tube feeding methods on feeding intolerance | 1 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| time to reach full enteral feeding | The effect of two different gavage tube feeding methods on time to reach full enteral feeding | 1 month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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preterm, feeding intolerence