Study Evaluating the Pronostic Value of Vascular Refilling Rate on Mortality in Chronic Kidney Disease Patients on Dialysis

Study Overview
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Brief Summary
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Aim of this study is to evaluate in a population of chronic kidney disease patients on dialysis (Stage 5D) during an observational period of 3 years: the prognostic value of vascular refilling rate on mortality and on the occurrence of i) cardiovascular events and ii) hospitalization number the prognostic value of interdialytic weight gain on mortality and on the occurrence of i) cardiovascular events and ii) hospitalization number the prognostic value of perdialytic weight loss on mortality and on the occurrence of i) cardiovascular events and ii) hospitalization number.

Official Title
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Evaluation of the Pronostic Value of Vascular Refilling Rate on Mortality in Chronic Kidney Disease Patients on Dialysis (Stage 5D)

Conditions
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Chronic Kidney Diseases

Participation Criteria
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Eligibility Criteria
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Inclusion criteria: Chronic Kidney Disease patient on dialysis (stage 5D) since at least september 2017 (3 months prior to study start date) Anuric patient Exclusion criteria: - Chronic Kidney Disease patient on dialysis with residual kidney function

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| All patients received conventional dialysis treatment<br>All patients received conventional dialysis treatment during an observational period of 3 years | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prognostic value of vascular refilling rate on mortality | The refilling rate will be assessed by the ratio of relative blood volume | 2 years after inclusion | 
| Prognostic value of vascular refilling rate on mortality | The refilling rate will be assessed by the ratio of relative blood volume | 3 years after inclusion | 
| Prognostic value of vascular refilling rate on mortality | The refilling rate will be assessed by the ratio UF max | 3 years after inclusion | 
| Prognostic value of vascular refilling rate on mortality | The refilling rate will be assessed by the ratio UF max | 2 years after inclusion | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prognostic value of interdialytic weight gain | Prognostic value of interdialytic weight gain | 2 years after inclusion | 
| Prognostic value of interdialytic weight gain | Prognostic value of interdialytic weight gain | 3 years after inclusion | 
| Prognostic value of perdialytic weight loss | Prognostic value of perdialytic weight loss | 2 years after inclusion | 
| Prognostic value of perdialytic weight loss | Prognostic value of perdialytic weight loss | 3 years after inclusion | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Chronic Kidney Disease patient on dialysis (stage 5D), Extracorporeal purification, Sodium