Contrast-associated Acute Kidney Injury in Patients With Different Types of Coronary Artery Disease

Study Overview
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Brief Summary
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The goal of the study is to assess the prevalence of contrast-associated acute kidney injury in patients with stable coronary artery disease, ST-elevation myocardial infarction and unstable angina/NSTEMI, assess the risk factors of contrast-induced acute kidney injury development and the influence of contrast-induced kidney injury on 1-year prognosis.

Official Title
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Contrast-associated Acute Kidney Injury in Patients With Different Types of Coronary Artery Disease

Conditions
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Coronary Artery Disease, Angina, Unstable, Angina, Stable, STEMI - ST Elevation Myocardial Infarction, NSTEMI - Non-ST Segment Elevation MI, Contrast-induced Nephropathy, Acute Kidney Injury

Intervention / Treatment
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* Other: Iodinated contrast


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Males and females aged 18-80 Stable CAD receiving optimal medical treatment requiring PCI or STEMI or NSTEMI Intra-arterial injection of iodinated contrast media Informed consent Exclusion Criteria: Age less than 18 Pregnancy, lactation Refuse to sign the informed consent Contraindications for PCI Other conditions affecting prognosis (oncology, liver failure etc) CKD stage 4-5 Patients receiving nephrotoxic drugs

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Stable coronary artery disease<br> | Other: Iodinated contrast<br>* Intra-arterial injection of iodinated contrast media during percutaneous coronary intervention<br>|
| ST-elevation myocardial infarction<br> | Other: Iodinated contrast<br>* Intra-arterial injection of iodinated contrast media during percutaneous coronary intervention<br>|
| Non-ST-elevation myocardial infarction<br> | Other: Iodinated contrast<br>* Intra-arterial injection of iodinated contrast media during percutaneous coronary intervention<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Contrast associated acute kidney injury | Number of patients with contrast associated kidney injury after contrast exposure | 48-72 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overall mortality |  | 1 year | 
| Cardiovascular mortality |  | 1 year | 
| Myocardial infarction | Number of patients with myocardial infarction | 1 year | 
| Stroke |  | 1 year | 
| Repeat revascularization | PCI or CABG | 1 year | 
| Repeat hospitalisation |  | 1 year | 
| Acute decompensation of heart failure | Number of patients with acute decompensation of heart failure | 1 year | 
| Chronic kidney disease progression | Progression of chronic kidney disease in patients with decreased glomerular filtration rate on inclusion | 1 year | 
| New-onset dialysis | Number of patients with new-onset dialysis | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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coronary artery disease, iodinated contrast media, stable angina, unstable angina, STEMI, NSTEMI, PCI, acute kidney injury