Prolonged Vasospasm in Subarachnoid Hemorrhage

Study Overview
=================
Brief Summary
-----------------
The prevalence and clinical implications of prolonged cerebral vasospasm in patients with subarachnoid hemorrhage are unknown.

Detailed Description
-----------------
The prevalence and clinical importance of prolonged cerebral vasospasm (after day 21 of bleeding) in patients with subarachnoid hemorrhage is unknown. Objectives: To determine the prevalence and clinical relevance of prolonged vasospasm in patients with subarachnoid hemorrhage secondary to cerebral aneurysm. A prospective and observational study was conducted. Adult patients with a diagnosis of subarcnoid hemorrhage CT scan or presence of blood in the cerebrospinal fluid were incorporated. Patients with vasospasm were followed daily with transcranial doppler. Those with technical impossibility to perform transcranial and pregnant Doppler were excluded. Day 0 was defined, the day of the last bleeding. Evaluation: 1) It was considered in patients with prolonged vasospasm: whether or not it was associated with clinical manifestation (deterioration of the sensory or new neurological deficit) and 2) the magnitude of the vasospasm (mild, moderate or severe) was measured by transcranial doppler.

Official Title
-----------------
Clinical Implication of Prolonged Vasospasm in Subarachnoid Hemorrhage

Conditions
-----------------
Subarachnoid Hemorrhage, Vasospasm, Intracranial

Intervention / Treatment
-----------------
* Diagnostic Test: transcranial doppler.


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Subarachnoid hemorrhage - Exclusion Criteria: Pregnancy -

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Prolonged vasospasm<br>Adult patients with a diagnosis of subarcnoid hemorrhage CT scan or presence of blood in the cerebrospinal fluid were incorporated. Patients with vasospasm were followed daily with transcranial doppler. Prolonged vasospasm was defined for patients who persisted with vasospasm after day 21 of cerebral bleeding. | Diagnostic Test: transcranial doppler.<br>* Daily monitoring of transcranial doppler until the disappearance of the intracranial vasosparm<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical implication | Presence or not of neurological symptoms related to intracranial vasospasm (delayed cerebral ischemia) | 1 month | 
| Gravity of vasospasm by transcranial doppler | Mild, moderate and severe according to Aaslid scale | 1 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality assessment | Mortality was assessed at hospital discharge and at six months | six monts | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Subarachnoid Hemorrhage, Vasospasm, Intracranial, Transcranial doppler