Does Biological Sex Influence the Cardiac Output Response to Sprint Interval Exercise Training in Humans?

Study Overview
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Brief Summary
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Sprint interval exercise training refers to brief repeated bouts of vigorous effort that are separated by short periods of recovery. Cardiac output refers to the amount of blood that is pumped out of the heart each minute. Research has shown that sprint interval exercise training can increase peak cardiac output - or the highest cardiac output that is achieved during strenuous exercise - but this response may be influenced by biological sex. The primary goal of this study is to determine whether the peak cardiac output response to 12 weeks of sprint interval exercise training differs between males and females. Cardiac output will be estimated using a non-invasive technique that involves breathing in a mixture of standardized gases. This research will help to determine whether biological sex influences the response of the heart to brief vigorous cycle exercise training.

Detailed Description
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The primary purpose of this study is to determine whether biological sex influences the peak cardiac output response to 12 weeks of sprint interval exercise training. Peak cardiac output will be determined non-invasively using an inert gas rebreathing technique. Each session of sprint interval exercise training will involve a 10-minute period of cycling on a stationary ergometer. The protocol will consist of a two-minute warm-up; three, 20-second 'all out' efforts that are separated by two minutes of recovery; and a three-minute cool down. Three sessions of training will be performed each week for a total of 12 weeks. Groups of male and female participants will be recruited and tested using best practice guidelines for sex-based comparisons of exercise responses. The study will advance knowledge regarding the potential for biological sex to influence the cardiovascular response to brief vigorous cycle exercise training.

Official Title
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Does Biological Sex Influence the Cardiac Output Response to Sprint Interval Exercise Training in Humans?

Conditions
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Exercise

Intervention / Treatment
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* Other: Sprint interval exercise training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Being untrained based on a self-report of engaging in < 1 h of weekly moderate to vigorous physical activity based on the Canadian Society for Exercise Physiology Get Active Questionnaire. Having an estimated cardiorespiratory fitness in the lower 50% of adults in the specified age range based on the online fitness calculator available at: www.worldfitnesslevel.org. Females who are naturally cycling (i.e., not using any form of hormonal contraceptive) or are using a 2nd generation oral contraceptive. Exclusion Criteria: Experiencing a condition that might preclude safe participation in physical activity and exercise, as determined by answering Yes to any question on Page 1 of the Canadian Society for Exercise Physiology Get Active Questionnaire. Females with a positive pregnancy test.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Females<br>Female participant group | Other: Sprint interval exercise training<br>* A 10-minute sprint interval exercise training protocol that is performed three times per week for a total of 12 weeks.<br>|
| Experimental: Males<br>Male participant group | Other: Sprint interval exercise training<br>* A 10-minute sprint interval exercise training protocol that is performed three times per week for a total of 12 weeks.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Peak cardiac output | Peak cardiac output measured during exercise | Change from baseline after 12 weeks of sprint interval exercise training | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Peak oxygen uptake | Peak oxygen uptake measured during exercise | Change from baseline after 12 weeks of sprint interval exercise training | 
| Flow mediated dilation | Brachial artery flow mediated dilation | Change from baseline after 4 and 12 weeks of sprint interval exercise training | 
| Pulse wave velocity | Central and peripheral pulse wave velocity | Change from baseline after 4 and 12 weeks of sprint interval exercise training | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cardiac output