Predictive Factors of Pelvic Magnetic Resonance in the Response of Arterial Embolization of Uterine Leiomyoma

Study Overview
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Brief Summary
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The purpose of this study is to determine predictive factors in the pelvic magnetic resonance in the response of arterial embolization of uterine leiomyoma.

Detailed Description
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This study followed symptomatic premenopausal women with uterine leiomyoma who underwent uterine artery embolization (UAE). Treatment was accompanied by magnetic resonance imaging of both the volume of the entire uterus and the leiomyomas one month before and six months after UAE. This patients were treated at the Uterine Leiomyoma Sector of the Department of Obstetrics and Gynecology, Medicine College of the University of São Paulo. In this study, the investigators examined 179 leiomyomas in 50 patients.

Official Title
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Predictive Factors of Pelvic Magnetic Resonance in the Response of Arterial Embolization of Uterine Leiomyoma

Conditions
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Exposure to Magnetic Field, Uterine Leiomyoma

Intervention / Treatment
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* Procedure: Magnetic Resonance Image


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ultrasound diagnosis of uterine leiomyoma presence of symptoms (menorrhalgia and/or pelvic pain) indication for UAE(the desire to keep the uterus and/or contraindications for surgery). Exclusion Criteria: malignant genital neoplasms pelvic inflammatory disease allergy to iodinated contrast coagulopathy, renal failure vasculitis pelvic irradiation pregnancy subserosal leiomyoma with a pedicle smaller than 50% of diameter of the fibroid.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Magnetic Resonanse Image<br>The leiomyomas were evaluated individually. MR was used to evaluate morphology: the radiological dimension(s) of the leiomyoma and uterus and the volume. The number of leiomyoma fibroid, and their location in the myometrium was classified. Perfusion and the characterization of the T2 signal were also evaluated. | Procedure: Magnetic Resonance Image<br>* The leiomyomas were evaluated individually. MR was used to evaluate morphology: the radiological dimension(s) of the leiomyoma and uterus and the volume. The number of leiomyoma fibroids was determined, and their location in the myometrium. Perfusion and the characterization of the T2 signal were also evaluated.<br>* Other names: Siemens Magnetom 3-Tesla;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Leiomyoma reduction in patients who underwent uterine artery embolization | Use the magnetic resonanse to evaluate factors that predicted leiomyoma reduction in patients who underwent uterine artery embolization | One month before(baseline) and six month after the embolization | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Leiomyoma, uterine artery embolization, magnetic resonance imaging