Technical Evaluation of Cardiovascular Magnetic Resonance Imaging and Spectroscopy

Study Overview
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Brief Summary
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Magnetic resonance imaging (MRI) and spectroscopy are diagnostic tools that create high quality images of the human body without the use of X-ray (radiation). MRI uses different levels of magnetic fields to create images of the body and organs. Occasionally, researchers will give patients undergoing a MRI an injection of a contrast substance. The contrast substance works by brightening areas of the magnetic resonance image. In this study researchers plan to use magnetic resonance imaging with contrast substances and exercise on normal volunteers in order to evaluate different aspects of its performance. Information gathered from this study may be used to develop more specific research studies involving MRI....

Detailed Description
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Technical evaluation of magnetic resonance imaging and spectroscopy will be performed on normal volunteers. These studies will be conducted in the NIH MRI systems located in Suburban Hospital in Bethesda, Maryland. These studies may involve the intravenous administration of commercially available MR contrast media and exercise. The results will be used to evaluate the performance of various pulse sequences, gradient coils, and RF coils on human subjects and will provide essential ground work for specific patient protocols.

Official Title
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Technical Evaluation of Cardiovascular Magnetic Resonance Imaging and Spectroscopy

Conditions
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Cardiovascular Disease, Healthy

Participation Criteria
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Eligibility Criteria
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INCLUSION CRITERIA: Any normal volunteer above the age 18 who is capable of giving informed consent will be included. EXCLUSION CRITERIA: A subject will be excluded if he/she has a contradiction to MR scanning. Brain aneurysm clip Implanted neural stimulator Implanted cardiac pacemaker implanted defibrillator Cochlear implant Ocular foreign body (e.g. metal shavings) Insulin pump Pregnant women (when uncertain, subjects will undergo urine or blood testing). Kidney Paralyzed hemidiaphragm Morbid obesity Claustrophobia Any condition in the PI's judgement which present unncessary risk EXCLUSION CRITERIA FOR GADOLINIUM ENHANCED STUDIES: Lactating women Subjects with hemoglobinopathies Asthma Renal or hepatic disease Subjects will be excluded if it is deemed that they have a condition that would preclude their use for technical development (e.g. paralyzed hemidiaphragm, morbid obesity, claustrophobia etc.) or present unnecessary risk (e.g. pregnancy, surgery of uncertain type, etc.). Lactating women and subjects with hemoglobinopathies, asthma, or renal or hepatic disease will be excluded from studies involving the adminstration of contrast agents.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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MRI, Cardiovascular, Imaging, Spectroscopy, Technical Development, Safety, Gadolinium, Heart, Toxicity, Adverse Events, Normal Volunteer