Study of Thyroid Status in Patients With IBD

Study Overview
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Brief Summary
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. The aim of the present study is to study thyroid state in patients with IBD

Detailed Description
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All patients were subjected to history taking and physical examination with emphasis on history of autoimmune disease, extraintestinal manifestations of IBD, neck examination for goiter, symptoms and signs of thyroid dysfunction. b) Laboratory investigations: Thyroid function test (include T3-T4- TSH) ESR - CRP - thyroid antibodies: (Anti TPO -Anti Thyroglobulin) c)-Imaging: Neck U/S on thyroid gland to identify patients with ultrasonographic evidence of autoimmune thyroiditis (diffuse hypoechogenicity or heterogenicity echotexture or both) and to detect thyroid nodularity. d ) Endoscopic findings regarding diagnosis of IBD confirmed by histopathological examination

Official Title
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Study of Thyroid State in Patients With Inflammatory Bowel Diseases

Conditions
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Thyroid Disease, Irritable Bowel Disease

Intervention / Treatment
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* Diagnostic Test: Thyroid tests


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All patients with IBD - Exclusion Criteria: patients with Thyroid disease Acute or chronic kidney Acute or Chronic Liver Disease. Active Lupus - Malignancy patients taking medications that affect thyroid function as rifampin, amiodarone …..
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with IBD<br>All patients were subjected to history taking and physical examination with emphasis on history of autoimmune disease, extraintestinal manifestations of IBD, neck examination for goiter, symptoms and signs of thyroid dysfunction. b) Laboratory investigations: Thyroid function test (include T3-T4- TSH) ESR - CRP - thyroid antibodies: (Anti TPO -Anti Thyroglobulin) c)-Imaging: Neck U/S on thyroid gland to identify patients with ultrasonographic evidence of autoimmune thyroiditis (diffuse hypoechogenicity or heterogenicity echotexture or both) and to detect thyroid nodularity. d ) Endoscopic findings regarding diagnosis of IBD confirmed by histopathological examination | Diagnostic Test: Thyroid tests<br>* Thyroid function test TSH ,T3,T4 Thyroid antibody test anti TPO,antithyroglobulin<br>* Other names: Thyroid function test and thyroid antibodies;|
| Healty individuals as a control group<br>All patients were subjected to history taking and physical examination with emphasis on history of autoimmune disease, extraintestinal manifestations of IBD, neck examination for goiter, symptoms and signs of thyroid dysfunction. b) Laboratory investigations: Thyroid function test (include T3-T4- TSH) ESR - CRP - thyroid antibodies: (Anti TPO -Anti Thyroglobulin) c)-Imaging: Neck U/S on thyroid gland to identify patients with ultrasonographic evidence of autoimmune thyroiditis (diffuse hypoechogenicity or heterogenicity echotexture or both) and to detect thyroid nodularity. | Diagnostic Test: Thyroid tests<br>* Thyroid function test TSH ,T3,T4 Thyroid antibody test anti TPO,antithyroglobulin<br>* Other names: Thyroid function test and thyroid antibodies;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percentage of thyroid disorders in patients with IBD | By use of Thyroid function test (include T3-T4- TSH), thyroid antibodies and thyroid sonography | 1 year |