linjc16/ctgov huggingface dataset:
Hip Reconstruction in Cerebral Palsy With Pelvic Osteotomy

Study Overview
=================
Brief Summary
-----------------
Prospective study enrolling patients with cerebral palsy and with subluxation of the hips > 40% and acetabular dysplasia. The patients will be stratified according the degree of subluxation and age. The treatment protocol is composed by femur variation osteotomy and periacetabular osteotomy. Patients will be divided in two groups according the type of bone graft used at periacetabular osteotomy (autologous or ceramic).

Conditions
-----------------
Cerebral Palsy

Intervention / Treatment
-----------------
* Procedure: periacetabular osteotomy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: hip subluxation > 40% and acetabular dysplasia Exclusion Criteria: previous hip surgery
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group A<br>bone graft - autologous | Procedure: periacetabular osteotomy<br> <br> |
| Group B<br>bone graft - ceramic | Procedure: periacetabular osteotomy<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Acetabular index |  | 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Reimers Index |  | 12 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
cerebral palsy, hip, luxation, subluxation
Prophylactic Antipyretic Treatment in Children Receiving Pneumococcal Conjugate and Standard Infant Vaccines

Study Overview
=================
Brief Summary
-----------------
The purpose of this trial is to assess if the rate of febrile reactions following the co-administration of pneumococcal conjugate vaccines with standard infant vaccines is lowered when paracetamol is given prophylactically.

Detailed Description
-----------------
2 groups (200 per group); control group receives no prophylactic antipyretic treatment.

Official Title
-----------------
Multicentre Study to Assess the Effect of Prophylactic Antipyretic Treatment on the Rate of Febrile Reactions Following Concomitant Administration of GSK Biologicals' 10-valent Pneumococcal Conjugate, Infanrix Hexa and Rotarix Vaccines

Conditions
-----------------
Infections, Rotavirus

Intervention / Treatment
-----------------
* Biological: 10 valent pneumococcal conjugate vaccine
* Biological: Infanrix Hexa
* Biological: Rotarix
* Drug: Paracetamol


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy children 9-16 weeks old and born after a gestation of at least 36 weeks. Exclusion Criteria: Body weight < 4.5 kg Children having received or planning to receive any investigational or non-registered products, vaccines not foreseen in the protocol, and immune modifying drugs Children with any disease that affects the immune system or gastro-intestinal tract Children with a history of seizures, allergic disease, or disease(s) covered by the vaccines Children with contraindication to paracetamol treatment.

Ages Eligible for Study
-----------------
Minimum Age: 9 Weeks
Maximum Age: 16 Weeks

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Biological: 10 valent pneumococcal conjugate vaccine|nan|
|Biological: Infanrix Hexa|nan|
|Biological: Rotarix|nan|
|Drug: Paracetamol|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Occurrence of fever > or = to 38°C (rectal temperature) |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Safety, reactogenicity and immunogenicity pre and post-vaccination |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Pneumococcal Disease
Companion Pharmacogenetic Study to UMCC 9900/9901

Study Overview
=================
Brief Summary
-----------------
The purpose is to examine the original breast tumor material to see how much of a metabolizing enzyme (CYP3A4) is present in tumor material. The researchers want to see if this is in any way associated with how the patient responded to docetaxel. They also want to examine the genes in the tumor that are responsible for the production of CYP metabolizing enzymes, to see if they are normal or if they have polymorphisms, or change compared to 'normal' CYP metabolizing enzymes.

Conditions
-----------------
Metastatic Breast Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients who participated on UMCC 9900/9901 Living patients must give written informed consent Exclusion Criteria: No tumor block tissue available

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Patients who participated in UMCC 9900/9901 (Phase II Studies of Tailored-Dose Docetaxel in Metastatic Breast Cancer)
Acute Kidney Injury in Major Abdominal Surgery: Retrospective Study of 501 Patients

Study Overview
=================
Brief Summary
-----------------
Retrospective study that aims to examine the presence of acute kidney injury (AKI) during major abdominal surgery, non- cardiac surgery. Using clinical and biochemical data in order to establish AKI frequency and risk factors.

Detailed Description
-----------------
Ethical approval was submitted and approved by the regional ethical committee, Etisk prövningsnämnd Uppsala, # 2017/418. Patients were selected from the time span of april 2016 to september 2017. The investigators identified 499 patients that had undergone any of the selected procedures. The procedures were, pancreatic resection, HIPEC surgery in colorectal setting, gynecological debulking in metastasized ovarian cancer, and liver resection. The risk of acute kidney injury (AKI) by the KDIGO definition during the postoperative period will be estimated in the group as a whole, and for each type of surgery separately. In addition the data will be stratified by sex to investigate systematic gender disparities or physiological differences. Length of stay, thirty day and sixty day mortality will secondary endpoints.

Official Title
-----------------
Acute Kidney Injury in Major Abdominal Surgery: Retrospective Study of 501 Patients

Conditions
-----------------
Acute Kidney Injury

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Any of the selected procedures. Exclusion Criteria: Patient has expressed his or her will to nor participate in any study.
Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Pancreatic resection<br> | |
| Liver resection<br> | |
| HIPEC surgery<br> | |
| Gynecological debulking surgery<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of AKI | Frequency of AKI as defined by KDIGO | the first 24- 72 hours postop | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality | 30, 60, and 360 day mortality rate | 30, 60 and 360 days postoperatively | 
| Major Adverse Kidney Events | Renal composite outcome according to Major Adverse Kidney Events (MAKE) | 30, 60 and 360 days postoperatively | 
| Fluid balance | Fluid balance during surgery, and the first postoperative days. | 24-72h | 
| Electrolyte disturbances | Any electrolyte disturbance. | 24-72h |
Do Childhood Measles and DTaP Vaccination Decrease the Mortality Rate Caused by COVID-19 in OECD Countries?

Study Overview
=================
Brief Summary
-----------------
Mortality rates caused by SARS CoV-2 differ between countries and this difference might be explained by several reasons. Childhood vaccination rate is thought to be one of them. Therefore present study aimed to examine the possible relationship between DTaP (diphtheria, tetanus, pertussis) and measles vaccination rates of Organization for Economic Co-operation and Development (OECD) countries and case fatality rate (CFR) caused by SARS CoV-2.

Detailed Description
-----------------
The mortality rates caused by SARS CoV-2 differ between countries and this difference might be explained by several reasons. Childhood vaccination rate is thought to be one of them. Therefore present study aimed to examine the possible relationship between DTaP (diphtheria, tetanus, pertussis) and measles vaccination rates of Organization for Economic Co-operation and Development (OECD) countries and case fatality rate (CFR) caused by SARS CoV-2.A total of 32 OECD countries, of northern hemisphere, have been included in this study. Statistical analysis performed according to the CFR data of these countries based on SARS CoV-2. The CFR data calculated according to the total mortality count of a specific country for the 3-month period down from the date when first SARS CoV-2 case was observed.

Official Title
-----------------
Do Childhood Measles and DTaP Vaccination Decrease the Mortality Rate Caused by SARS CoV-2 in OECD Countries?

Conditions
-----------------
Covid19, Measles Vaccine, Mortality

Intervention / Treatment
-----------------
* Other: Case fatality rate


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Children vaccinated in OECD countries in northern hemisphere Exclusion Criteria: Non vaccinated children Southern hemisphere countries non-OECD countries
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Case fatality rate|Mortality rate caused by SARS CoV-2|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Case Fatality Rate | Mortality rate caused by SARS CoV-2 | 4 months |
Oocyte Vitrification Aided With Latrunculin A

Study Overview
=================
Brief Summary
-----------------
Using cytoskeleton Stabilizer the Latrunculin A would improve the outcome of oocyte vitrification

Official Title
-----------------
Latrunculin A for Oocyte Vitrification

Conditions
-----------------
Infertility

Intervention / Treatment
-----------------
* Other: Latrunculin A supplemented vitrification medium


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: indication for oocyte cryopreservation Exclusion Criteria: -

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 42 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Latrunculin A supplemented vitrification medium<br> | Other: Latrunculin A supplemented vitrification medium<br>* Vitrification of human oocyte in medium supplemented with Latrunculin A<br>|
| No Intervention: Vitrification medium with no supplementation<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| survival after thawing |  | 6 days after thawing | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| fertilization rate |  | 6 days of culture | 
| Rates of blastocyst formation and quality | Number of formed blastocyst and high-quality blastocysts per fertilized oocytes | 6 days of culture | 
| embryo utilization rate | Number of utilized embryos per fertilized oocytes | 6 days of culture | 
| clinical pregnancy rate | Number of pregnant women with fetal pulsation per recruited cycles | three months | 
| ongoing pregnancy rate |  | 12 months |
Clinical Orthopaedic Data Bank (Acute and Chronic)

Study Overview
=================
Brief Summary
-----------------
Data involving orthopaedic conditions and rehabilitation aspects of musculoskeletal and neuromuscular disorders will be collected and stored as part of the normal clinical care of patients seen in the University of Florida (UF) and Shands Orthopaedics and Sports Medicine Institute.

Detailed Description
-----------------
All patients seen the Orthopaedic clinic will be informed of the data collection and asked to participate. If the patient is agreeable to participation, informed consent will then be obtained.

Official Title
-----------------
Orthopaedic Data Bank; Collection and Storage of Data Relating to Orthopaedic Disorders

Conditions
-----------------
Osteoarthritis, Osteosarcoma, Scoliosis, Cerebral Palsy

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All patients seen in the UF&Shands Orthopaedics and Sports Medicine Institute will be asked to sign an informed consent. Exclusion Criteria: No exclusions, all patients interested in participation will be asked to sign an informed consent.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Retrospective data | Medical Record information will be used as needed for a future IRB retrospective study | 2007 to present, until 2020 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Rotator Cuff Tear
Correlating Real and Virtual World Behavioral Fluctuations in Adolescence

Study Overview
=================
Brief Summary
-----------------
The present study will explore a new approach to ongoing evaluation and monitoring of fluctuations in personality traits via commercial video games. The aim of this longitudinal study is to examine the influence of everyday life event on video games performance as a function of individual differences in gaming behavioral patterns. focusing on the ongoing performance vacillations of the patient on commercial video games will offer insights in to possibly new generation of real time assessment medium of ongoing behavior.

Official Title
-----------------
Correlating Real and Virtual World Behavioral Fluctuations in Adolescence

Conditions
-----------------
Attention-Deficit and Hyperactivity Disorder, Anxiety, Disruptive Mood Dysregulation Disorder, Depression, Oppositional Defiant Disorder, Conduct

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All subjects will have normal or corrected to normal vision with no sensory/motor disturbance An accessible computer at the house hold Previous experience in playing computer games. Exclusion Criteria: drug abuse head injury living in a boarding school and a major psychiatric or neurological disorder.

Ages Eligible for Study
-----------------
Minimum Age: 13 Years
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Control<br>Adolescents without any psychiatric disorder | |
| Study<br>Adolescents with psychiatric disorder of the following: Attention-Deficit and Hyperactivity Disorder, Conduct, Oppositional defiant Disorder, Anxiety, Depression, Disruptive Mood Dysregulation Disorder | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Impulsivity manifested within game-play | In-Game kill/Stealth ratio | 3 weeks | 
| Activity manifested within game-play | In-Game number of missions and sub-mission attained | 3 weeks | 
| Aggresion manifested within game-play | In-Game aimed killing | 3 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Attention-Deficit and Hyperactivity Disorder, Anxiety, Impulsivity, Computer Games, Depression
Prospective Observational Cohort Study of Critically Ill Patients With Covid-19 in Sweden

Study Overview
=================
Brief Summary
-----------------
The study will prospectively collect data from patients with Covid-19 admitted to the Västerås Intensive Care Unit, Västerås Hospital. Demographic, clinical, radiographic and laboratory characteristics will be recorded. Analysis of data to identify predictors of disease severity, mortality and treatment response.

Official Title
-----------------
Characteristics and Outcomes of Critically Ill Patients With Covid-19 in a Large Swedish County Hospital - a Prospective Observational Cohort Study

Conditions
-----------------
Covid-19, Critical Illness

Intervention / Treatment
-----------------
* Other: Observational study


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients admitted to the Intensive Care Unit with biological samples positive for SARS-CoV-2. Patients admitted to the Intensive Care Unit with one or more negative tests but with clinical and radiological characteristics highly suggestive of SARS-CoV-2 and thus considered positive for the disease. Exclusion Criteria: None.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Covid-19<br>Patients with verified or highly suggestive Covid-19 diagnosis and Intensive Care treatment. | Other: Observational study<br>* Not required<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| All-cause mortality |  | At 90 days follow-up after admittance to Intensive Care | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hospital length of stay |  | Until 90 days after admittance to Intensive Care | 
| ICU length of stay |  | Until 90 days after admittance to Intensive Care | 
| Number of days on mechanical ventilation |  | Until 90 days after admittance to Intensive Care | 
| Number of patients receiving vasopressor support |  | Until 90 days after admittance to Intensive Care | 
| Number of patients receiving renal replacement therapy |  | Until 90 days after admittance to Intensive Care | 
| Patient characteristics |  | At admission to ICU |
Post-operative Pain After Shoulder Surgery

Study Overview
=================
Brief Summary
-----------------
A prospective observational study conducted at the American University of Beirut Medical center that targets patients undergoing shoulder surgeries. It is conducted to to prospectively collect patient, surgery and anesthesia-related variables and perform correlation studies with postoperative pain severity, patients' satisfaction and analgesic consumption following shoulder surgery. In addition, identifying predictors for postoperative pain will contribute to adjust pain management protocols as per surgical and patients' factors.

Official Title
-----------------
Predictors of Post-operative Pain in Shoulder Surgery, a Prospective Observational Study

Conditions
-----------------
Pain, Shoulder

Intervention / Treatment
-----------------
* Procedure: Shoulder surgery and post-op pharmacological treatment


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All adult patients > 18 years old admitted to the American University of Beirut - Medical Center for any shoulder surgery Exclusion Criteria: Patients suffering of opioids addiction (or previous history of addiction) or drug abuse.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Shoulder surgery and post-op pharmacological treatment|Usual care surgery (shoulder arthroscopy) and post-operative pain management protocol|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative change in pain intensity (NRS pain scale) | Asses the change in pain intensity after the surgery using the NRS pain score (0-10) | 24 hours, 3 days and one week after surgery | 
| Postoperative change in satisfaction with pain management (NRS satisfaction scale) | Asses the change in satisfaction with the pain management protocol using the NRS satisfaction score (0-10) | 24 hours, 3 days and one week after surgery | 
| Postoperative analgesic consumption | Analgesic consumption over one week after the surgery | Over one week | 
| Postoperative functional level (QuickDASH questionnaire) | The QuickDASH questionnaire includes questions about the symptoms and ability to do certain activities | One week after surgery |