The Effect of Anesthesia Type on Pulmonary Function

Study Overview
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Brief Summary
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The role of neuraxial anesthesia in preventing respiratory complications is a controversial in elderly patients. The aim of the study was to evaluate the benefits of neuraxial anesthesia on pulmonary function during post-operative term in geriatric patients undergoing to elective non-abdominal surgery.

Detailed Description
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Sixty elder patients will be randomly assigned to General anesthesia or Neuraxial anesthesia groups. Spirometry, will be performed at pre-operative and post-operative terms. Pulmonary function tests will be evaluated.

Official Title
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The Effect of General or Spinal Anesthesia on Pulmonary Function Tests in Geriatric Patients

Conditions
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Anesthesia, Geriatric Patients

Intervention / Treatment
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* Procedure: General anesthesia
* Procedure: Neuraxial anesthesia
* Diagnostic Test: Spirometer


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 65 years of age Undergoing non-abdominal surgery under anesthesia in supine position Exclusion Criteria: Pulmonary disease Hematological disease Undergoing Abdominal surgery Non-supine position during surgery Nicotine Abuse

Ages Eligible for Study
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Minimum Age: 65 Years
Maximum Age: 95 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Screening
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: General Anesthesia<br>Standard General Anesthesia will be applied.The change of the pulmonary functions will be evaluated via spirometer. | Procedure: General anesthesia<br>* induction with the intravenous anesthetic (Propofol) and maintenance with the inhalational anesthetic (Sevoflurane)<br>Diagnostic Test: Spirometer<br>* Pulmonary function will be evaluated via the portable spirometer (MIR Spirodoc, Spirodoc®, Roma, Italy)<br>|
| Active Comparator: Neuraxial Anesthesia<br>Neuraxial anesthesia will be applied. The change of the pulmonary functions will be evaluated via spirometer. | Procedure: Neuraxial anesthesia<br>* Spinal anesthesia will be applied via the local anesthetic ( Bupivacaine).<br>Diagnostic Test: Spirometer<br>* Pulmonary function will be evaluated via the portable spirometer (MIR Spirodoc, Spirodoc®, Roma, Italy)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The changes on forced vital capacity | Forced vital capacity will be measured via spirometer | At Preoperative, postoperative 2. hours, postoperative 24. hours | 
| The changes on forced expiratory volume in 1 s | Forced expiratory volume in 1 s will be measured via spirometer | At Preoperative, postoperative 2. hours, postoperative 24. hours | 
| The changes on mid-expiratory flow (MEF 25-75) | mid-expiratory flow (MEF 25-75) will be measured via spirometer | At Preoperative, postoperative 2. hours, postoperative 24. hours | 
| The changes on peak expiratory flow (PEF) | Peak expiratory flow (PEF) will be measured by the spirometer | At Preoperative, postoperative 2. hours, postoperative 24. hours |