Sarcopenia and Orthostatic Hypotension

Study Overview
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Brief Summary
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Elderly patients generally have a tendency for having sarcopenia which refers to muscle loss that may be related to many factors. These patients also have a tendency to falls and injuries. Whether elderly sarcopenic patients have abrupt blood pressure drops upon standing remains unknown. Therefore, in this study, we sought to determine the incidence of orthostatic hypotension in sarcopenic elderly patients and compare it with elderly patients with no sarcopenia.

Official Title
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The Relationship Between Sarcopenia and Orthostatic Hypotension

Conditions
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Orthostatic Hypotension, Sarcopenia

Intervention / Treatment
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* Diagnostic Test: blood pressure measurement


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients 75 years or older Exclusion Criteria: Pace-maker End stage renal insufficiency End stage malignancy Dehydration Severe anemia ( Hgb < 8 gr/dl) Acute infection Marked edema Neurodegenerative disease

Ages Eligible for Study
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Minimum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Elderly with sarcopenia<br>50 patients aged 75 or older with sarcopenia Intervention: Each patient's supine and standing blood pressures will be measured. | Diagnostic Test: blood pressure measurement<br>* Intervention: Each patient's supine and standing blood pressure measurements will be recorded<br>|
| Elderly without sarcopenia<br>50 patients aged 75 or older without sarcopenia Intervention: Each patient's supine and standing blood pressures will be measured. | Diagnostic Test: blood pressure measurement<br>* Intervention: Each patient's supine and standing blood pressure measurements will be recorded<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in blood pressure | All blood pressure measurements will be performed in the morning after an eight-hour fasting. After 5-minute rest, the first blood pressure measurement will be taken when the patients are supine. Later, three more consecutive measurements will be recorded when the patients stand up each being one-minute apart. All measurements will be performed using a fully automated sphygmomanometer that is attached with the correctly sized cuff matching to the patients' upper arm circumference. OH is defined as a decrease in systolic blood pressure of 20 mm Hg or a decrease in diastolic blood pressure of 10 mm Hg within 3 minutes of standing. The accompanying symptoms such as dizziness, unable to maintain balance, blurred vision will also be recorded. | 0-3 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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blood pressure, elderly, sarcopenia, fall