Aerobic Training, Aerobic-resistance Training and Glucose Profile (CGMS) in Type 2 Diabetes

Study Overview
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Brief Summary
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Many studies were already performed showing beneficial cardiovascular and metabolic effects of physical training for type 2 diabetic patients. However, glucose profile during and immediately after a short period of aerobic and/or resistance training was not studied yet. Continuous glucose monitoring system (CGMS) has now been added to the repertoire of technological devices useful in the management of patients with diabetes. Such monitoring enables clinicians to detect occult hypoglycemia and hyperglycemia not otherwise discernable with intermittent testing of blood glucose. The main aim of the present study is to investigate continuous blood glucose profile (using CGMS) over 72h, beginning 24h before and ending 24h after a single bout of aerobic or aerobic/resistance physical training in type 2 diabetic patients.

Detailed Description
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Many studies were already performed showing beneficial cardiovascular and metabolic effects of physical training for type 2 diabetic patients. However, glucose profile during and immediately after a short period of aerobic and/or resistance training was not studied yet. Continuous glucose monitoring system (CGMS) has now been added to the repertoire of technological devices useful in the management of patients with diabetes. Such monitoring enables clinicians to detect occult hypoglycemia and hyperglycemia not otherwise discernable with intermittent testing of blood glucose. The main aim of the present study is to investigate continuous blood glucose profile (using CGMS) over 72h, beginning 24h before and ending 24h after a single bout of aerobic or aerobic/resistance physical training in type 2 diabetic patients.

Official Title
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Acute and Subacute Effects of Aerobic Training vs Aerobic/Resistance Training Upon Glucose Profile Evaluated Through Continuous Glucose Monitoring System in Type 2 Diabetes

Conditions
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Diabetes Mellitus, Type 2, Treatment, Exercise

Intervention / Treatment
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* Behavioral: Acute aerobic exercise
* Behavioral: Acute aerobic-resistance exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Type 2 diabetic patients treated with diet and metformin, 35-65 years old Exclusion Criteria: Type 1 diabetic patients Treatment with insulin or sulphonylureas or glitazones Proliferative retinopathy Severe autonomic neuropathy Coronary artery disease Baseline fasting plasma glucose>200 mg/dl Peripheral artery disease Amputation Heart failure Diabetic nephropathy Renal failure

Ages Eligible for Study
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Minimum Age: 35 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Aerobic exercise<br>One bout of aerobic physical training will be performed on a cycle ergometer for 50 min | Behavioral: Acute aerobic exercise<br>* Aerobic exercise (on a cycle ergometer, for 50 min)<br>* Other names: There are no other names;|
| Experimental: Aerobic-resistance exercise<br>One bout of aerobic-resistance physical training will be performed on a cycle ergometer added by a strenght training for 50 min (total) | Behavioral: Acute aerobic-resistance exercise<br>* Aerobic-resistance exercise (on a cycle ergometer plus strength training, for 50 min in total)<br>* Other names: There are no other names;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Reduction of the prevalence of hyperglycemic peaks during a 24-h period after a bout of aerobic or aerobic/resistance exercise in type 2 diabetes patients on metformin/diet therapy. |  | 24h | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Diabetes mellitus, Exercise, Endurance, Resistance, Continuous glucose monitoring system