Short-term Impact of COVID-19 Lockdown on Metabolic Control of Type 2 Diabetes

Study Overview
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Brief Summary
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The strict rules applied in Italy during the recent COVID-19 pandemic, with the prohibition to attend any regular outdoor activity, are likely to influence the degree of metabolic control of patients with type 2 diabetes. The aim of this observational, prospective, single centre study was to evaluate the immediate impact of the lockdown rules on the metabolic profile of a cohort of patients with type 2 diabetes.

Detailed Description
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All the patients with type 2 diabetes who were previously scheduled for a follow-up visit in our outpatient diabetes clinic during the lockdown for COVID-19 (March 9, 2020-May 04, 2020) were contacted by phone. Patients who accepted to take part of the study received a medical prescription for routine analysis via email. They were asked to perform blood drawing one week after the end of the lockdown period and transmitted us the results. We then compared the metabolic profile tested one week after the end of the lockdown with the last value and the mean of the last three determinations performed before the pandemic emergency.

Official Title
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Determining the Impact of COVID-19 Lockdown on Metabolic Control in Individuals With Type 2 Diabetes

Conditions
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Type 2 Diabetes, Metabolic Control

Intervention / Treatment
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* Other: antidiabetic treatment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: type 2 diabetes at least two previous clinical records in the last two years Exclusion Criteria: age >85 years first access to the outpatient clinic type 1 diabetes

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with Type 2 Diabetes<br>Patients with type 2 diabetes and a scheduled visit during the lockdown for COVID-19 | Other: antidiabetic treatment<br>* Every kind of antidiabetic treatment, oral or injective, were considered including patients treated only with diet<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Glucose | Blood glucose was expressed in mg/dl and was determined by standard techniques. | One week after the end of the lockdown period | 
| HbA1c | HbA1c was expressed as percentage or mmol/l and was determined by standard techniques. | One week after the end of the lockdown period | 
| Lipid profile | Complete lipid profile (total cholesterol, HDL cholesterol, LDL cholesterol, Triglcerydes) were expressed in mg/dl or mmol/l and were determined by standard techniques. | One week after the end of the lockdown period | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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T2D, Sars-Cov-2, COVID-19 lockdown, metabolic control, sedentary