linjc16/ctgov huggingface dataset:
Should Colorectal Cancer Patients be Followed After Five Years? Study of Recurrence in a Population Cohort

Study Overview
=================
Brief Summary
-----------------
The results of this study will make it possible, thanks to better understanding of the natural history of colorectal cancer, to define new treatment and surveillance strategies for colorectal cancers resected with curative intent, so as to improve management and thus improve patient survival. These data will also make it possible to calculate the prevalence of patients who require treatment or surveillance because of their disease.

Conditions
-----------------
Colorectal Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: with adenocarcinoma of the colon or rectum (ICD-O: C18, C19 and C20) residing in the département of Côte-d'Or (501,000 inhabitants according to the 1999 census) or Calvados (511, 012 inhabitants) at the moment of diagnosis recorded by either Registry between January 1985 and December 2000 treated by resection with a curative intent. Exclusion Criteria: Will be excluded other morphologic tumours and initially metastatic colorectal cancers, anal cancers.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| data concerning evolving relapse | the date of recurrence the site the finality of the surgical treatment (resection with curative intent defined as macroscopically complete resection, without involvement of the surgical margin in the histological examination) the non-surgical adjuvant or palliative treatments (radiotherapy, chemotherapy). | during the 10 years following resection for colorectal cancer with curative intent |
Observational Usage Study of Statins in Primary Care in France

Study Overview
=================
Brief Summary
-----------------
To describe the way statins are used in France in primary care, that is to determine patients profile (particularly CV risk factors), to determine the way statins are initiated by general practitioners, to evaluate aftercare and to assess patients treated by rosuvastatin

Official Title
-----------------
Observational Usage Study of Statins in Primary Care in France

Conditions
-----------------
Healthy

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients to whom a statin was initiated or switched between 3 and 6 months before consultation
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>Patients to whom a statin was initiated or switched between 3 and 6 months before consultation | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
statins, rosuvastatin, cross sectional study, France, CV risk factors
One Month Degarelix/Comparator Treatment for Prostate Cancer in Chinese Population

Study Overview
=================
Brief Summary
-----------------
One month degarelix/comparator treatment for prostate cancer in Chinese population

Official Title
-----------------
An Open-label, Multi-centre, Randomised, Parallel-group Trial, Comparing Efficacy and Safety of Degarelix One-month Dosing Regimen With Goserelin in Chinese Patients With Prostate Cancer Requiring Androgen Ablation Therapy

Conditions
-----------------
Prostate Cancer

Intervention / Treatment
-----------------
* Drug: Degarelix
* Drug: Goserelin


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Chinese male over 18 years Adenocarcinoma of the prostate Relevant disease status based on lab values and as judged by the physician Life expectancy of at least a year Exclusion Criteria: Previous hormonal treatment for prostate cancer Considered to be candidate for curative therapy Risk or history of any serious or significant health condition Has received an investigational drug within the last 28 days and no previous treatment with degarelix

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Degarelix<br>Degarelix 240/80 mg | Drug: Degarelix<br> <br> |
| Active Comparator: Goserelin<br>Goserelin 3.6 mg | Drug: Goserelin<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cumulative probability of testosterone at castrate level (≤0.5 ng/mL) |  | Day 28 to Day 364 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Proportion of patients with testosterone levels ≤0.5 ng/mL |  | at Day 3 | 
| Percentage change in prostate-specific antigen (PSA) |  | from baseline to Day 28 | 
| Changes in testosterone and PSA levels |  | Day 0 to 364 | 
| Significant changes in laboratory values |  | Day 0 to Day 364 | 
| Significant changes in vital signs |  | Day 0 to Day 364 | 
| Significant changes in body weight |  | Day 0 to Day 364 | 
| Frequency and severity of adverse events |  | Day 0 to Day 364 | 
| Cumulative probability of no PSA failure | PSA failure defined as two consecutive (at least two weeks apart) increase of 50 percentage and at least 5ng/mL increase compared to nadir | Day 0 to Day 364 |
Study of Post Menopausal Osteoporosis (PMO) Among Gynecology Outpatients in Pakistan

Study Overview
=================
Brief Summary
-----------------
This observational study will provide an opportunity to document local patterns of susceptibility, patient profile, and usefulness of screening in postmenopausal patients coming to gynecology outpatient clinics in Pakistan. This will also capture the initial management of PMO in diagnosed patients. The information gathered will serve as a foundation for developing national guidelines on screening and management of PMO in Pakistan.

Official Title
-----------------
Registry on Post Menopausal Osteoporosis in Gynecology Setting in Pakistan (REPOSE)

Conditions
-----------------
Postmenopausal Osteoporosis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Postmenopausal women Age 50 years or greater Exclusion Criteria: Previously diagnosed osteoporosis, or receiving treatment for osteoporosis

Ages Eligible for Study
-----------------
Minimum Age: 50 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Study Population<br>Gynecology outpatients who meet eligibility criteria will be enrolled and evaluated for the presence of PMO at screening. Women diagnosed with PMO will complete an additional visit to document the prescribed management plan. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percentage of patients diagnosed with PMO based upon dual-energy X-ray absorptiometry (DXA) results |  | Up to 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Use of various PMO treatment modalities |  | Up to 12 months |
Improving Quality of Care for Hip-Fracture Patients: Studies on Fast-track Surgery

Study Overview
=================
Brief Summary
-----------------
The aims of the studies are to examine the impact of delayed time to surgery for hip-fracture patients with regard to in-hospital complication rate and one-year mortality and to evaluate two different fast-track systems for hip-fracture patients with regard to patient outcome, complication rate and patient satisfaction.

Detailed Description
-----------------
The aims of the studies are to examine the impact of delayed time to surgery for hip-fracture patients with regard to in-hospital complication rate and one-year mortality and to evaluate two different fast-track systems, the hip process pathway and the ambulance process pathway, for hip-fracture patients with regard to patient outcome, complication rate and patient satisfaction.

Official Title
-----------------
Improving Quality of Care for Hip-Fracture Patients: Studies on Fast-track Surgery

Conditions
-----------------
Hip Fractures

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Hip fracture Exclusion Criteria: Periprosthetic fractures Pathological fractures
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Hip-fracture patients<br>Hip-fracture patients admitted to Orthopaedic Department of Danderyd Hospital | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Complication rate | The 3-month medical complication rate | 3-months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality rate | One-year mortality rate | 1-year |
Quantification of Kinematics and Muscle Activity Patterns of the Upper Extremities of Individuals With Motor Disabilities

Study Overview
=================
Brief Summary
-----------------
The subjet is sitting on a chair and in front of him an adjustable (height) table with a glass of water. 17 passive reflective markers are placed on his upper extremities and torso. The subject is requested to reach the glass (once with the right hand and then with the left hand) and bring it to the mouth and drink. Then the subject put the glass back at the starting position. This is performed twice for each hand. In the second part, the same trial is repeated but muscle activity is recorded with surface electromyography.

Official Title
-----------------
Quantification of Kinematics and Muscle Activity Patterns of the Upper Extremities of Individuals With Motor Disabilities

Conditions
-----------------
Diagnosis and Follow up on Upper Extremity Interventions

Intervention / Treatment
-----------------
* Other: Rehabilitative treatment


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: motor impairment following stroke, multiple sclerosis, cerebral palsy, traumatic brain injury, spina bifida, poliomyelitis, neuropathy Able to understand and sign an informed consent form independently. Exclusion Criteria: Unable to hold or lift a glass pregnant women

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Rehabilitative intervention<br>Surgical intervention, orthotics or injections of muscle/nerve medications as prescribed by the treating physician and unrelated to the study. | Other: Rehabilitative treatment<br>* Surgical intervention, orthotics or injections of muscle/nerve medications as prescribed by the treating physician and unrelated to the study.<br>* Other names: injections of muscle/nerve medications;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| joint angle |  | 2 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
upper extremity, muscle activity, kinematics, motion capture, Electromyography
Liver Transplantation From Living Donors For Treatment Of Non-Resectable Colorectal Carcinoma Liver Metastases: A Registry Study

Study Overview
=================
Brief Summary
-----------------
The goal of this study is to create a data registry to capture clinical, pathologic, and molecular data/outcomes for patients with metastatic colorectal cancer who undergo live donor liver transplantation.

Official Title
-----------------
Liver Transplantation From Living Donors For Treatment Of Non-Resectable Colorectal Carcinoma Liver Metastases: A Registry Study

Conditions
-----------------
Colorectal Cancer Metastatic

Intervention / Treatment
-----------------
* Procedure: Liver transplantation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age ≥ 18 Non-amenable to curative hepatic resection as defined by FLR <30% Histologically confirmed adenocarcinoma of the colon or rectum Candidate for LDLT for colorectal liver metastasis per the University of Rochester liver transplant program Exclusion Criteria: Not a candidate of the LDLT liver transplant protocol for treatment of colorectal liver metastasis. Unwilling to consent

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| All Participants<br>Potential subjects for this registry must have Stage IV colorectal cancer with liver metastases and be candidates for liver transplantation based on multidisciplinary discussion by the Liver transplantation team. Patients must demonstrate favorable tumor biology and no evidence of extra hepatic disease. | Procedure: Liver transplantation<br>* living donor liver transplantation<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| percentage of patients with recurrence free survival |  | 5 years | 
| percentage overall survival |  | 5 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
liver transplantation, living donor, unresectable colorectal liver metastases
Effects of Dry Needling on Neck and Shoulder Pain in Orchestral Musicians: a Prospective Case Series

Study Overview
=================
Brief Summary
-----------------
This study evaluates the effectiveness of Deep dry needling of active myofascial trigger points present in muscles of the neck and shoulder region in orchestral musicians.

Official Title
-----------------
Effects of Myofascial Trigger Point Dry Needling on Neck Pain in Orchestral Musicians

Conditions
-----------------
Pain Syndrome, Musculoskeletal Pain, Trigger Point Pain, Myofascial

Intervention / Treatment
-----------------
* Procedure: Deep dry needling


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Orchestral musicians Chronic neck or shoulder pain Presence of active myofascial trigger points Exclusion Criteria: Fear of needles Coagulation disorders Pregnancy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Interventional Model Description: Deep dry needling
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Intervention<br>Deep dry needling applied on active myofascial trigger points in the shoulder and neck regions | Procedure: Deep dry needling<br>* Insertion of a filiform needle in the active trigger point of musculoskeletal muscle<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Visual analogue scale for pain | Pain measurement. 100-mm visual analog scale (VAS), horizontal line ranging from 0mm (no pain) to 100mm (worst imaginable pain). | 2 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pressure pain threshold | Analogic algometer | 2 weeks | 
| Neck disability index (NDI) | 10-item, 50-point index that assesses different aspects of daily functioning in patients with neck pain. It assesses four items regarding subjective symptoms (pain intensity, headache, concentration, sleeping), four items regarding activities of daily living (lifting, work, driving, recreation), and two items regarding discretionary activities of daily living (personal care, reading). Each item is scored 0 to 5, with the total reported as either a raw score (0-50) or as a percentage score. Higher values represent a worse outcome. | 2 weeks | 
| Shoulder pain disability index (SPADI) | Self-administered questionnaire, grouping 13 questions, 5 of which measure the severity of pain caused by various arm movements involving the shoulder, the pain being assessed on a numeric pain scale ranging from 0 to 10. Eight additional questions related to functional impairments of the shoulder are assessed with a numeric scale. Higher values represent a worse outcome. | 2 weeks |
Radiomics of Hepatocellular Carcinoma

Study Overview
=================
Brief Summary
-----------------
We propose a radiomics approach to identify prognostic biomarkers of HCC and provide patients with some reasonable advice for their therapies.

Detailed Description
-----------------
Radiomics is emerging fields that is based on quantitative analysis of medical images. Tri-phasic CT images are currently the standard imaging modality for the management of HCC. Our goal is to improve treatment decisions of HCC patients through better understanding of their prognosis based on radiomics modeling of HCC. Radiomics is defined as the extraction of quantitative image features from medical images. We will use triphasic CT data of at least 200 patients and develop a robust strategy to extract imaging features from CT. We will use deep learning in the form of a Convolutional Neural Network to segment HCC lesions and use image feature extraction algorithms with supervised classification to predict prognosis.

Official Title
-----------------
Quantitative Imaging for Evaluation of Response to Cancer Therapies

Conditions
-----------------
Hepatocellular Carcinoma

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: The purpuse of our research is to improve treatment ,therefore we have no creteria. Exclusion Criteria: -
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| quantitative image features extracted from CT images can be used as imaging marker for prognosis |  | five(year) | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Radiomics, prognosis, medical images, Hepatocellular carcinoma
Postoperative Cognitive Dysfunction in Patients Undergoing Pituitary Removal Surgery

Study Overview
=================
Brief Summary
-----------------
As postoperative cognitive dysfunction rates are high especially in elder patients, cognitive dysfunction is not diagnosed and treated effectively. This statement is associated with prolonged hospital stays by increasing morbidity. We wanted to see the incidency of postoperative cognitive dysfunction in patients undergoing elective pituitary tumor removal surgery.

Official Title
-----------------
Postoperative Cognitive Dysfunction in Patients Undergoing Pituitary Removal Surgery

Conditions
-----------------
Pituitary Tumor

Intervention / Treatment
-----------------
* Diagnostic Test: standardized minimental testing


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: ASA I-II patients Undergoing elective pituitery tumor removal surgery Exclusion Criteria: >II ASA scores Using antidepressant agents Patient refusal Mental diseases

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group1<br>patients undergoing pituitary tumor removal surgery will be tested with standardized minimental testing. | Diagnostic Test: standardized minimental testing<br>* To diagnose postoperative cognitive dysfunction<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| minimental test score | scores between 0-30 | preoperative 24th hour | 
| minimental test score | scores between 0-30 | postoperative 4th hour | 
| minimental test score | scores between 0-30 | postoperative 24th hour | 
| minimental test score | scores between 0-30 | one month after discharged |