Tai Ji Quan and Cognitive Function in Older Adults With Mild Cognitive Impairment

Study Overview
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Brief Summary
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To determine the efficacy of a cognitively enhanced exercise intervention - Tai Ji Quan: Moving to Maintain Brain Health in improving global cognitive function and dual-task ability in older adults with mild cognitive impairment.

Detailed Description
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The primary aim of the study is to determine the efficacy of a cognitively enhanced exercise intervention - Tai Ji Quan: Moving to Maintain Brain Health, relative to a standard Tai Ji Quan intervention and an exercise stretching control, in improving global cognitive function and dual-task ability among community-dwelling older adults with amnestic mild cognitive impairment.

Official Title
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Efficacy of Adapted Tai Ji Quan to Slow Cognitive Decline in Older Adults

Conditions
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Mild Cognitive Impairment

Intervention / Treatment
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* Behavioral: The Go for Exercise & Healthy Aging Project


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: complaint of memory loss clinical dementia rating (CDR) scale score ≤0.5 having normal general cognitive function screened, with MMSE ≥24 capable of exercising safely, as determined by a healthcare provider willingness to be randomly assigned to an intervention condition and complete the 24-week intervention and 6-month follow-up Exclusion Criteria: having medical conditions likely to compromise survival, such as metastatic cancer, or render a participant unable to engage in physical activity, such as severe cardiac failure participating in any type of Tai Ji Quan or daily and/or structured vigorous physical activity (i.e., brisk walking for exercise 30 minutes or longer at a time, or engaging in muscle-strengthening activities, e.g., weight lifting on 3 or more days per week 3 months prior to the study)

Ages Eligible for Study
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Minimum Age: 65 Years
Maximum Age: 95 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Cognitively enhanced Tai Ji Quan<br>Participants in this arm will exercise a series of Tai Ji Quan-based movements with configurations that are specifically designed for older adults to improve cognitive function, dual-task ability, strength/balance, and mobility. | Behavioral: The Go for Exercise & Healthy Aging Project<br>* Exercise and Cognition<br>|
| Active Comparator: Standard Tai Ji Quan<br>Serving as an active comparison arm, participants in this intervention will exercise a series of Tai Ji Quan-based movements that are specifically designed for older adults to improve strength/balance, cognitive function, and mobility. | Behavioral: The Go for Exercise & Healthy Aging Project<br>* Exercise and Cognition<br>|
| Sham Comparator: Stretching<br>Serving as a control arm, participants in this intervention will engage in a series of light exercise activities consisting of breathing, stretching, and body relaxation. | Behavioral: The Go for Exercise & Healthy Aging Project<br>* Exercise and Cognition<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Montreal Cognitive Assessment | Change in global cognitive function from baseline to 24 weeks | baseline, 6 months | 
| gait under a dual-task condition - walking with no cognitive task, walking with a concurrent cognitive task | Change in dual-task ability from baseline to 24 weeks | baseline, 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical Dementia Rating | Change in cognitive decline from baseline to 24 weeks | baseline, 6 months | 
| Paper-and-pencil domain-specific cognitive battery tests | Change in domain-specific cognitive function from baseline to 24 weeks | baseline, 6 months | 
| Computerized cognitive battery tests | Change in domain-specific cognitive function from baseline to 24 weeks | baseline, 6 months | 
| Physical performance - Functional Reach; Short Physical Performance Battery | Change in physical performance from baseline to 24 weeks | baseline, 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cognitive function, mild cognitive impairment, Tai Ji Quan