Comparison of Dietary Fats on Vascular Parameters

Study Overview
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Brief Summary
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The purpose of the study is to examine the effect of consuming 50g of fat from 5 different sources (coconut, canola, grapeseed, chia, and butter) on arterial stiffness, blood pressure and blood glucose levels. It is hypothesized that butter will have the most detrimental effect on acute vascular function. Canola, grapeseed and chia oil with their decreased content of SFA are hypothesized to impair vascular function to a lesser extent.

Official Title
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Acute Effects of Dietary Fats on Postprandial Vascular Function in Healthy Individuals: Pilot Double Blind, Randomized, Controlled Trial

Conditions
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Healthy

Intervention / Treatment
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* Other: Coconut Oil
* Other: Canola Oil
* Other: Grapeseed Oil
* Other: Chia Oil
* Other: Butter


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy Age 18-65 years BMI < 30 kg/m2 Brachial systolic blood pressure ≤ 140 mmHg Brachial diastolic blood pressure ≤ 90 mmHg Exclusion Criteria: Women of childbearing age must not be pregnant or breastfeeding at the time of the study BMI >35kg/m2 Hypertensive as defined by brachial SBP >140mmHg and/or DBP >90mmHg Sensitivity to the study product or its sources Presence of chronic conditions or illnesses Having any gastrointestinal complication or condition Chronic use of dietary supplements that alter fat absorption

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Coconut oil<br> | Other: Coconut Oil<br>* Shake with 50 g Coconut oil<br>Other: Canola Oil<br>* Shake with 50 g Canola oil<br>Other: Grapeseed Oil<br>* Shake with 50 g Grapeseed oil<br>Other: Chia Oil<br>* Shake with 50 g Chia oil<br>Other: Butter<br>* Shake with 50 g Butter<br>|
| Experimental: Canola oil<br> | Other: Coconut Oil<br>* Shake with 50 g Coconut oil<br>Other: Canola Oil<br>* Shake with 50 g Canola oil<br>Other: Grapeseed Oil<br>* Shake with 50 g Grapeseed oil<br>Other: Chia Oil<br>* Shake with 50 g Chia oil<br>Other: Butter<br>* Shake with 50 g Butter<br>|
| Experimental: Grapeseed oil<br> | Other: Coconut Oil<br>* Shake with 50 g Coconut oil<br>Other: Canola Oil<br>* Shake with 50 g Canola oil<br>Other: Grapeseed Oil<br>* Shake with 50 g Grapeseed oil<br>Other: Chia Oil<br>* Shake with 50 g Chia oil<br>Other: Butter<br>* Shake with 50 g Butter<br>|
| Experimental: Chia oil<br> | Other: Coconut Oil<br>* Shake with 50 g Coconut oil<br>Other: Canola Oil<br>* Shake with 50 g Canola oil<br>Other: Grapeseed Oil<br>* Shake with 50 g Grapeseed oil<br>Other: Chia Oil<br>* Shake with 50 g Chia oil<br>Other: Butter<br>* Shake with 50 g Butter<br>|
| Placebo Comparator: Butter<br> | Other: Coconut Oil<br>* Shake with 50 g Coconut oil<br>Other: Canola Oil<br>* Shake with 50 g Canola oil<br>Other: Grapeseed Oil<br>* Shake with 50 g Grapeseed oil<br>Other: Chia Oil<br>* Shake with 50 g Chia oil<br>Other: Butter<br>* Shake with 50 g Butter<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To compare 5 different dietary fat sources in a liquid meal on postprandial changes in augmentation index (AIx) |  | 5 separate mornings, measurements taken at baseline and at 60, 120 and 180 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To investigate whether these dietary fat sources will result in blood pressure changes and a differential glycemic response |  | 5 separate mornings, blood pressure measurements will be taken at baseline, 60, 120 and 180 minutes. Blood samples will be taken at baseline 15, 30, 45, 60, 90 and 120 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Healthy, Arterial Stiffness, Blood Pressure, Blood Glucose, Vascular Function