Molecular Epidemiology of Lymphoma Patients

Study Overview
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Brief Summary
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Primary Objectives: To enroll and obtain, through questionnaires, risk factor information on all study participants to develop detailed demographic, epidemiologic and behavioral profiles. To assess the influence of relevant epidemiologic covariates such as age, gender, smoking and family history of cancer on the panel of susceptibility biomarkers. To evaluate the role of genomic instability in development of lymphomas.

Detailed Description
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This study will include individuals diagnosed with lymphoma and individuals with no history of cancer. Half of the participants in this study will have lymphoma, and half will have no history of cancer. Information from both groups will be compared to help researchers try to learn which factors may lead to the development of lymphoma. If you agree to take part in this study, you will be asked to complete a questionnaire at M. D. Anderson. In this questionnaire, you will be asked about your demographics (such as your age, sex, etc.), certain environmental exposures (such as pollution), your medical history, family history, diet, and your past and present smoking and alcohol use habits. This questionnaire should take about 50 minutes to complete. You will also have about 2 ½ tablespoons of blood drawn for special tests. These tests will look for any biologic factors (such as changes in your DNA) that may be linked to lymphoma. You will not be informed of the results of any of the testing done with your blood samples. Your participation will be over in this study once your blood has been drawn. This is an investigational study. Up to 800 participants will take part in this study. All will be enrolled at M. D. Anderson.

Official Title
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Molecular Epidemiology of Lymphoma Patients

Conditions
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Lymphoma

Intervention / Treatment
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* Behavioral: Questionnaire


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Cases only: Newly diagnosed, previously untreated patients with lymphoma as the primary cancer. Age 18 years and older. Willing to donate 30ml of blood. Willing to complete a self-administered questionnaire. Controls only: No prior cancer. Exclusion Criteria: Cases only: Prior history of cancer other than lymphoma. Unable to speak or read English

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cases<br>Participants of study with newly diagnosed lymphoma. | Behavioral: Questionnaire<br>* Questions about cancer risk factors, medical history, and family history of cancer.<br>* Other names: Survey;|
| Control<br>Participants of study from matched control group. | Behavioral: Questionnaire<br>* Questions about cancer risk factors, medical history, and family history of cancer.<br>* Other names: Survey;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To identify biologic (such as genes) and lifestyle factors that may increase a person's risk of developing lymphoma. |  | 4 Years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Lymphoma, Epidemiology, Lifestyle Factors, Questionnaire, Survey