Effects of Exercise Training on Cognitive Function and Neurotrophic Factors in Overweight Adults

Study Overview
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Brief Summary
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The BrainFit Study aims to examine acute effects of High Intensity Interval- vs Resistance or Combined program has benefits on Cognitive Function as well as on secretion and regulation of neurotrophic factors or neurotrophins in a cohort of sedentary, overweight adults (aged 18-30 years) from Bogota, Colombia.

Official Title
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Effects of High Intensity Interval- vs Resistance or Combined- Training for Improving Cognitive Function and Neurotrophic Factors in Overweight Adults (BrainFit Study): Factorial Randomised Controlled Trial

Conditions
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Cognitive Function, Motor Activity, Obesity

Intervention / Treatment
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* Behavioral: Experimental: High Intensity Interval
* Behavioral: Resistance training
* Behavioral: Plus: High Intensity Interval + Resistance Training
* Other: Non-exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Written informed consent. Interested in improving health and fitness. Central obesity: waist circumference ≥90cm Body mass index ≥ 26 kg/m(2) Exclusion Criteria: Systemic infections. Weight loss or gain of >10% of body weight in the past 6 months for any reason. Currently taking medication that suppresses or stimulates appetite. Uncontrolled hypertension: systolic blood pressure 160 mm Hg or diastolic blood pressure 95 mm Hg on treatment. Gastrointestinal disease, including self-reported chronic hepatitis or cirrhosis, any episode of alcoholic hepatitis or alcoholic pancreatitis within past year, inflammatory bowel disease requiring treatment in the past year, recent or significant abdominal surgery (e.g., gastrectomy). Asthma. Diagnosed diabetes (type 1 or 2), fasting impaired glucose tolerance (blood glucose 118 mg/dL), or use of any anti-diabetic medications. Currently taking antidepressant, steroid, or thyroid medication, unless dosage is stable (no change for 6 months). Any active use of illegal or illicit drugs. Current exerciser (>30 min organized exercise per week). Indication of unsuitability of current health for exercise protocol (PARQ).

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 30 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: High Intensity Interval<br>One session for 30-60 minutes of high intensity aerobic exercise | Behavioral: Experimental: High Intensity Interval<br>* Walking on a treadmill 4min at 80-90% peak heart rate and recovery 4 min at 65% peak heart rate until expenditure of 500 kcal<br>|
| Experimental: Resistance training<br>One session for 30-60 minutes of resistance exercise | Behavioral: Resistance training<br>* Completing a resistance circuit (including upper and lower muscle groups) as many times as needed according to subject weight until expenditure of 500 kcal<br>|
| Experimental: Plus: High Intensity Interval + Resistance Training<br>One session for 30-60 minutes of high intensity aerobic exercise and resistance exercise | Behavioral: Plus: High Intensity Interval + Resistance Training<br>* Walking on a treadmill as intervention 1 until 50% the energy expenditure prescribed is reached, then completing a resistance circuit until 100% energy expenditure is reached<br>|
| Placebo Comparator: Non-exercise<br>Non-exercise | Other: Non-exercise<br>* This group will receive the usual clinical care according to the consensus recommendations of the national goals for cardiovascular health promotion and disease reduction of the American Heart Association and Colombian guidelines COLDEPORTES.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from Baseline in Brain-derived neurotrophic factor | Measurement of serum Brain-derived neurotropic factor true blood samples. | Baseline and 60 minutes immediately after the interventions ends | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from Baseline in Neurotrophin-3 |  | Baseline and 60 minutes immediately after the interventions ends | 
| Change from Baseline in Neurotrophin-4 |  | Baseline and 60 minutes immediately after the interventions ends | 
| Change from Baseline change in Cognitive Function | Cognitive Performance Test (BPT) computerized cognitive assessment battery developed by Lumos Labs, Inc. | Baseline and 60 minutes immediately after the interventions ends |