Blood Levels of Sevoflurane and Desflurane

Study Overview
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Brief Summary
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16 patients with American Society of AnesthesioIogy (ASA) physical status I-III will recruited to this study. Patients will divided to the 2 groups. %1.5 Sevoflurane will apply in Group S and %6 Desflurane will apply in Group D. Each groups will divide 2 subgroups. Two lung ventilation will be performed to Group Sa and Group Da, one lung ventilation will be performed to Group Sb and Group Db. At the time point 40.minutes first blood sample will given from patients. Blood sample will be taken at intervals of 10 minutes from groups of two lung ventilation. In groups of one lung ventilation, blood samples will be taken at the time interval of 10 minutes after one lung ventilation started. All blood samples will be assess in Gas Chromatography.

Detailed Description
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Investigator aimed to assess blood level of sevoflurane and desflurane during two lung ventilation and one lung ventilation. The investigators will use Gas Chromatography for define drugs levels. 16 patients with ASA I-III patients who undergo thoracotomy and abdominal surgery will be recruited to this study. Patients will divided in to the 2 groups. %1.5 Sevoflurane will apply in Group S and %6 Desflurane will apply in Group D during anesthesia maintenance. Each groups will divide 2 subgroups which are one lung ventilation groups and two lung ventilation groups. Two lung ventilation will be performed to Group Sa and Group Da, one lung ventilation will be performed to Group Sb and Group Db. Sequential blood samples will be taken from both arterial and central venous canula at the same time point. First blood samples will be taken at 40. minutes of anesthesia. Sequential samples will be taken at interval of 10 minutes during two lung ventilation. In one lung ventilation second blood samples will be taken at the 10. minutes of one lung ventilation. After than at the interval of 10 minutes, collection of blood samples both arterial and central venous will be continue. All collection will assess with gas chromatography.

Official Title
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Blood Levels of Sevoflurane and Desflurane During One Lung Ventilation

Conditions
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Anesthetics, Inhalation

Intervention / Treatment
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* Drug: Sevoflurane
* Drug: Desflurane


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ASA I-II patients Who undergo thoracotomy or abdominal surgery Exclusion Criteria: ASA IV and up patients Patients who taken inotropic agent

Ages Eligible for Study
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Minimum Age: 25 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| two lung ventilation of Sevoflurane<br>In GroupSa, 1,5 % sevoflurane will be apply continuously and blood samples will be taken at intervals of 10 minutes starting from the 40th minute. | Drug: Sevoflurane<br>* Measurement of blood desflurane level during one lung ventilation<br>* Other names: Blood sevoflurane level;|
| one lung ventilation of Sevoflurane<br>In GroupSa, 1,5 % sevoflurane will be apply continuously and first samples will taken at the 40. minutes and collection of blood samples will be continue at intervals of 10 minutes after one lung ventilation started. | Drug: Sevoflurane<br>* Measurement of blood desflurane level during one lung ventilation<br>* Other names: Blood sevoflurane level;|
| two lung ventilation of Desflurane<br>In GroupSa, 6 % desflurane will be apply continuously and blood samples will be taken at intervals of 10 minutes starting from the 40th minute. | Drug: Desflurane<br>* Measurement of blood desflurane level during one lung ventilation<br>* Other names: Blood desflurane level;|
| one lung ventilation of desflurane<br>In GroupSa, 6 % desflurane will be apply continuously and first samples will taken at the 40. minutes and collection of blood samples will be continue at intervals of 10 minutes after one lung ventilation started. | Drug: Desflurane<br>* Measurement of blood desflurane level during one lung ventilation<br>* Other names: Blood desflurane level;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measurement of blood levels of Sevoflurane and Desflurane | Data collections will be ensured from arterial and venous blood sample and than samples will be assessed with gas chromatography and blood sevoflurane and desflurane level will be measured. Blood samples will take every 10 minutes. Only blood levels of sevoflurane and desflurane will be assessed. | from 40th minute to the end of the operation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| determine of ventilation-perfusion mismatch with p(A-a)O2 | During one lung ventilation, p(a-A)O2 will be assessed with arterial blood analyses | from 40th minute to the end of the one lung ventilation | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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blood sevoflurane concentration, blood desflurane concentration, one lung ventilation