Comparison of Detection and Miss Rates of Blue Laser Imaging Versus Conventional White Light Colonoscopy

Study Overview
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Brief Summary
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It is a randomized controlled trial with tandem colonoscopy.Participants were randomized for use of either blue laser imaging or conventional White Light Colonoscopy on withdrawal method.comparison of detection and miss rates of BLI group Versus conventional White Light Colonoscopy.

Detailed Description
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blue laser imaging (BLI) are a new imaging systems used in endoscopy which are recently developed. According to three recently published reports, the diagnostic ability of adenoma characterization using blue laser imaging compares favorably with narrow band imaging. No published data are available to date regarding adenoma detection with blue laser imaging.BLI has the possibility to increase the detection of colorectal polyps by sufficient brightness and clearer endoscopic images.The investigators recruited participants who underwent colonoscopy for symptoms,screening,or surveillance.Participants were randomized for use of either blue laser imaging (BLI) or conventional white light colonoscopy on withdrawal method.Lesions detected on first-pass and second-pass examination were used for adenoma detection and miss rates,respectively.The primary outcomes is to compare the adenoma and poly detection rates of BLI with conventional white light Colonoscopy.

Official Title
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Comparison of Detection and Miss Rates of Colorectal Adenoma by Blue Laser Imaging (BLI) Versus Conventional White Light Colonoscopy.

Conditions
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Colorectal Adenoma

Intervention / Treatment
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* Device: blue laser imaging colonoscopy
* Device: conventional white light colonoscopy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: consecutive patients who were underwent colonoscopy in our center for diagnostic work up of colonic symptoms,surveillance of colorectal polyps, and colorectal cancer screening. Exclusion Criteria: history of colon cancer, colectomy familial adenomatous polyposis, or inflammatory bowel diseases; severe intestinal stenosis or obstruction;coagulation，disorders; pregnancy; and colonoscopy examinations with inadequate bowel cleanliness

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Blue Laser Imaging colonoscopy<br>Insertion to cecum was performed under white light(WL) and once the cecum was reached, the Blue Laser Imaging mode was switched on during withdrawal of endoscope for complete colonic examination. Second colonoscopic examination was performed in a similar manner after the first complete withdrawal of the colonoscope. WL was used on insertion and WL was used on withdrawal | Device: blue laser imaging colonoscopy<br>* Insertion to cecum was performed under white light(WL) and once the cecum was reached, the Blue Laser Imaging mode was switched on during withdrawal of endoscope for complete colonic examination. Second colonoscopic examination was performed in a similar manner after the first complete withdrawal of the colonoscope. WL was used on insertion and WL was used on withdrawal<br>|
| Experimental: conventional white light colonoscopy<br>In this arm, WL was used for both insertion and withdrawal of the colonoscope during the first-pass and second-pass examinations. | Device: conventional white light colonoscopy<br>* In this arm, WL was used for both insertion and withdrawal of the colonoscope during the first-pass and second-pass examinations.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| comparison of colorectal adenoma detection rates of blue laser imaging (BLI) Versus conventional White Light Colonoscopy |  | 6 months | 
| comparison of colorectal adenoma miss rates of blue laser imaging (BLI) Versus conventional White Light Colonoscopy |  | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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blue laser imaging,detection,randomized trial