The Effect of Preoperative Ketamine on the Emergence Characteristics in Children Undergoing Entropion Surgery

Study Overview
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Brief Summary
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The investigators evaluate extubation time and recovery profiles in children undergoing entropion surgery.

Detailed Description
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This study will compare the extubation time and recovery profiles (degree of postoperative agitation and cough) between sevoflurane group and desflurane group. General anesthesia will maintained with sevoflurane 2-3vol% or desflurane 6-7vol%. After surgery, the investigators will measure the duration of extubation and recovery profiles between two groups.

Official Title
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The Effect of Preoperative Ketamine on the Emergence Characteristics After Desflurane or Sevoflurane Anesthesia in Children Undergoing Entropion Surgery

Conditions
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Entropion

Intervention / Treatment
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* Drug: Sevoflurane
* Drug: Desflurane


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: American society of anesthesiologist class 1 patients 3-6 years children undergoing entropion surgery Exclusion Criteria: Do not agree with participate this study

Ages Eligible for Study
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Minimum Age: 3 Years
Maximum Age: 6 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Sevoflurane Group<br>The patients will maintained general anesthesia with sevoflurane. | Drug: Sevoflurane<br>* Intravenous ketamine will administrate to the patients for decreasing of separation anxiety of children. General anesthesia will maintained with sevoflurane 2-3 vol%.<br>* Other names: sevofrane;|
| Experimental: Desflurane Group<br>The patients will maintained general anesthesia with desflurane. | Drug: Desflurane<br>* Intravenous ketamine will administrate to the patients for decreasing of separation anxiety of children. General anesthesia will maintained with desflurane 6-7vol%.<br>* Other names: suprane;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Extubation Time | compare the extubation time between sevoflurane and desflurane group | 30 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Degree of Postoperative Agitation | Postoperative agitation will measure using Pediatric Anesthesia Emergence Delirium (PAED) scale. PAED scale is (1) The child makes eye contact with the caregiver (2) The child's action are purposeful (3) The child is aware of his/her surrounding (4) The child is restless (5) The child is inconsolable. It scores 0-4, and total maximum score is 20. PAED score > 12 was used to determine occurence of postoperative agitation. | 30 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Anesthesia, Agitation, Extubation