Comparison of Aerobic, Resistance, and Combined Training in Overweight/Obese Hypertensive Adults

Study Overview
=================
Brief Summary
-----------------
To compare the effects of aerobic, resistance and combined training in hypertensive obese patients

Official Title
-----------------
Compare the Effects of Aerobic, Resistance, and Combined Training in Overweight/Obese Hypertensive Adults

Conditions
-----------------
Obese, Hypertension

Intervention / Treatment
-----------------
* Other: Aerobic exercise training Group
* Other: Resistance Exercise Training Group
* Other: Combined Exercise Training Group


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Hypertensive with BP greater than 140/90 mmHg Overweight and obese adults with BMI (25-40) Physically inactive from past 6 months assessed with pedometer. Those with step count of less than 7000 will be included To be able to exercise (6MWT),t hose who completed the test without any symptom Exclusion Criteria: Any active systemic illness that restricts exercise People doing exercise on regular basis Any cardiopulmonary , metabolic and neurological illness

Ages Eligible for Study
-----------------
Minimum Age: 40 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Aerobic exercise training Group<br> | Other: Aerobic exercise training Group<br>* Aerobic Exercise includes Treadmill walking At Week 1-2, intensity of 40-45% Heart rate maximum (HR max), 3 days/week, for 30 minutes At Week 3-4, intensity of 45-50% HR max, 3 days /week, for 30 minutes At Week 5-6, intensity of 50-60% HR max 3 days per week, for 30 minutes<br>|
| Experimental: Resistance Exercise Training Group<br> | Other: Resistance Exercise Training Group<br>* Resistive Exercises includes (a) Leg press b) Quadriceps extension c) Bicep curl d) Hip abduction. At Week 1-2, 10 repetitions 1 set, 3 days/week, for 30 minutes At Week 3-4, 2 sets of 10 repetitions, 3 times /week for 30 minutes At week 5-6, 2 sets of 10 repetitions with 5 sec hold 3 times per week for 30 minutes<br>|
| Experimental: Combined Exercise Training Group<br> | Other: Combined Exercise Training Group<br>* Combined Exercise training includes [Aerobic: Treadmill walking + Resistive Training: a) Leg press b) Quadriceps extension c) Bicep curl d) Hip abduction] Time will be reduced to 15 minutes for both trainings in respective weeks. Aerobic Exercise includes Treadmill walking At Week 1-2, intensity of 40-45% Heart rate maximum (HR max), 3 days/week, for 15 minutes At Week 3-4, intensity of 45-50% HR max, 3 days /week, for 15 minutes At Week 5-6, intensity of 50-60% HR max 3 days per week, for 15 minutes Resistive Exercises At Week 1-2, 10 repetitions 1 set, 3 days/week, for 15 minutes At Week 3-4, 2 sets of 10 repetitions, 3 times /week for 15 minutes At week 5-6, 2 sets of 10 repetitions with 5 sec hold 3 times per week for 15 minutes<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Systolic and diastolic blood pressure | Changes from the Baseline, Blood pressure is measured through sphygmomanometer | 6 weeks | 
| Body Mass Index (BMI) | Changes from the Baseline, Body mass index (BMI) will be calculated as weight (kg)/height (m2). Below 18.5 Underweight 18.5 - 24.9 Healthy Weight 25.0 - 29.9 Overweight 30.0 and Above Obesity | 6 Week | 
| Change in blood lipid profile | Change in plasma total cholesterol, high density lipoproteins cholesterol (HDL), and low density lipoproteins cholesterol (LDL) after each treatment. | 6 Week | 
| Step Count | Pedometer is a valid self-report measure of physical activity. Pedometer is used to count the average daily steps. Change from the baseline to 6 week will be compared. | 6 week | 
| Waist circumference | Waist circumference will be measured for abdominal or central fat mass. It is measured in cm at the middle distance between the last floating rib and the iliac crest using a retractable ergonomic measuring tape. Change from the baseline to 6 week will be compared. | 6 week | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Aerobic Exercise, Resistive exercise, Combined Aerobic and Resistive Exercise