The Inland Norway Healthy Life Center Study

Study Overview
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Brief Summary
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Healthy Life Centers (Norwegian, 'Frisklivssentralen') is a municipal service in Norway that aims to promote both physical and mental health, as well as to limit the development of non-communicable diseases. Previous research has shown that receiving follow-up from Healthy Life Centers has led to higher levels of daily physical activity, in addition to improved self-reported health and quality of life among the participants. However, there is a lack of studies that have examined what kind of physiological health effects can be expected from participating in the Healthy Life Center's follow-up. In this study, responses to the 12-week physical activity program of the Healthy Life Center will be compared with the responses in a negative control group that does not receive such follow-up. Both the intervention group and the reference group (the negative control group) will carry out the same tests and measurements before and after the 12 week period. The tests will include measurements of anthropometric variables (body height, body weight and waist circumference), body composition, arterial stiffness, resting blood pressure and blood variables (blood glucose, long-term blood glucose, blood lipid profile and inflammation markers), in addition to physical tests of mobility, balance, maximum aerobic capacity (maximal oxygen consumption) and maximum muscle strength. Questionnaires related to adherence to the Healthy Life Center follow-up, socio-demographic variables, eating and drinking habits, activity level, perceived physical fitness, motivation for exercise, and health-related quality of life will also be included.

Official Title
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The Inland Norway Healthy Life Center Study

Conditions
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Non-Communicable Chronic Diseases, Obesity, Insulin Resistance, Musculoskeletal Diseases, Psychological Disorder, Cardiovascular Diseases

Intervention / Treatment
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* Other: Physical activity


Participation Criteria
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Eligibility Criteria
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Intervention group Inclusion Criteria: >18 years of age Receiving follow-up from the Healthy Life Center Exclusion Criteria: In average >1 weekly exercise training session the last three months Reference group Inclusion Criteria: >18 years of age Exclusion Criteria: In average >1 weekly exercise training session the last three months Receiving follow-up from the Healthy Life Center

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Intervention group<br>Participants in the intervention group will receive 12-week follow-up from the Healthy Life Center | Other: Physical activity<br>* The participants will receive the possibility to attend weekly endurance, resistance and yoga exercise sessions administered by the Healthy Life Center. They will also receive personalized follow-up from the Healthy Life Center, and have the possibility to exercise at the local gym.<br>|
| No Intervention: Control group<br>Participants in the intervention group will not receive follow-up from the Healthy Life Center | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Maximal oxygen consumption (measured in mL/kg body mass/min) | Difference in change between the two study arms from before to after the 12-week intervention/control period | From before to after the 12-week intervention/control period | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Balance, measured using the single leg stance test (measured in seconds) | Difference in change between the two study arms from before to after the 12-week intervention/control period | From before to after the 12-week intervention/control period | 
| Mobility, measured using the sit-and-reach and the back stretch test (measured in centimeters) | Difference in change between the two study arms from before to after the 12-week intervention/control period | From before to after the 12-week intervention/control period | 
| Fat mass (measured in kilograms) | Difference in change between the two study arms from before to after the 12-week intervention/control period | From before to after the 12-week intervention/control period | 
| Lean mass (measured in kilograms) | Difference in change between the two study arms from before to after the 12-week intervention/control period | From before to after the 12-week intervention/control period | 
| Bone mineral density ( measured in g/cm2) | Difference in change between the two study arms from before to after the 12-week intervention/control period | From before to after the 12-week intervention/control period | 
| Visceral fat (measured in grams) | Difference in change between the two study arms from before to after the 12-week intervention/control period | From before to after the 12-week intervention/control period | 
| Blood glucose levels (serum, fasted state) | Difference in change between the two study arms from before to after the 12-week intervention/control period | From before to after the 12-week intervention/control period | 
| Cholesterol and total triglyceride levels (serum, fasted state) | Difference in change between the two study arms from before to after the 12-week intervention/control period | From before to after the 12-week intervention/control period | 
| Resting blood pressure | Difference in change between the two study arms from before to after the 12-week intervention/control period | From before to after the 12-week intervention/control period | 
| Systemic inflammation markers (levels of c-reactive protein, TNF-alpha, interleukin 6 and interleukin 8 in serum, fasted state) | Difference in change between the two study arms from before to after the 12-week intervention/control period | From before to after the 12-week intervention/control period | 
| Arterial stiffness | Difference in change between the two study arms from before to after the 12-week intervention/control period | From before to after the 12-week intervention/control period | 
| Health-related quality of life (measured using the SF-36 questionnaire; scores from 0-100, where a higher score means a better outcome) | Difference in change between the two study arms from before to after the 12-week intervention/control period | From before to after the 12-week intervention/control period | 
| Body mass index | Difference in change between the two study arms from before to after the 12-week intervention/control period | From before to after the 12-week intervention/control period | 
| Maximal muscle strength (measured in newtons produced during a leg press exercise) | Difference in change between the two study arms from before to after the 12-week intervention/control period | From before to after the 12-week intervention/control period | 
| Maximal muscle power (measured in watts produced during a leg press exercise) | Difference in change between the two study arms from before to after the 12-week intervention/control period | From before to after the 12-week intervention/control period | 
| Waist circumference | Difference in change between the two study arms from before to after the 12-week intervention/control period | From before to after the 12-week intervention/control period |