The Effect of Phosphatidylserine on Time Trial Performance in Trained Male Cyclists

Study Overview
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Brief Summary
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Phosphatidylserine is a phospholipid found in high concentrations in the brain and nervous tissues along with naturally occurring in many foods. It has been extensively studied for its effects on improving cognitive function, learning, memory and alleviating stress. However, more recently it has been proposed that phosphatidylserine could improve exercise capacity. The mechanisms of proposed action are difficult to distinguish because of the limited research and therefore the purpose of this study is to identify the proposed mechanism of action of phosphatidylserine supplementation and to establish whether these mechanisms will have an effect on time trial performance in trained male cyclists.

Official Title
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The Effect of Phosphatidylserine on Time Trial Performance in Trained Male Cyclists

Conditions
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The Focus of the Study is to Investigate the Effects of Phosphatidylserine Supplementation on Exercise Physiology and Cycling Time-trial Performance

Intervention / Treatment
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* Dietary Supplement: Phosphatidylserine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Cyclists Maximum oxygen uptake of at least 55 mL/kg/min Exclusion Criteria:

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Participants matched on cycling time-trial performance and then randomly assigned to treatment or placebo groups
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Phosphatidylserine, 800 mg per day, 10 days<br> | Dietary Supplement: Phosphatidylserine<br>* 800 mg per day for 10 days<br>|
| Placebo Comparator: Maltodextrin, 800 mg per day, 10 days<br> | Dietary Supplement: Phosphatidylserine<br>* 800 mg per day for 10 days<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 30 minute cycling time-trial power output on an electromagnetically-braked cycle ergometer | Mean power output | From baseline to 11 days post supplementation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Oxygen consumption at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer | Evaluated using an online breath-by-breath gas analyser | From baseline to 11 days post supplementation | 
| Respiratory exchange ratio at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer | Evaluated using an online breath-by-breath gas analyser | From baseline to 11 days post supplementation | 
| Breathing frequency at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer | Evaluated using an online breath-by-breath gas analyser | From baseline to 11 days post supplementation | 
| Minute ventilation at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer | Evaluated using an online breath-by-breath gas analyser | From baseline to 11 days post supplementation | 
| Blood lactate concentration at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer | Obtained via capillary puncture and analysed using an automated analyser | From baseline to 11 days post supplementation | 
| Blood glucose concentration at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer | Obtained via capillary puncture and analysed using an automated analyser | From baseline to 11 days post supplementation | 
| Rating of perceived exertion at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer | Evaluated using a 15-point (6-20) scale | From baseline to 11 days post supplementation | 
| Heart rate at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer | Evaluated using a heart rate monitor | From baseline to 11 days post supplementation |