Assessment of Cognitive Function in Patients Undergoing Carotid Artery Stent Placement

Study Overview
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Brief Summary
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To determine the effect of carotid artery stenting, on cognitive function, in patients with high grade carotid artery stenosis

Detailed Description
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Single Center, Case Controlled design using pre and post stent cognitive function testin. Patients will serve as self controls to observe the effect, if any, of carotid stent placement on cognitive function in asymptomatic patients with high grade carotid artery stenosis

Official Title
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Assessment of Cognitive Function in Patients Undergoing Carotid Artery Stent Placement: Cognitive Function in Carotid Stenting

Conditions
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Cognitive Function in Carotid Stenting

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 40-80 years of age Right hand dominate Asymptomatic:defined as: no symptoms of TIA/stroke in the previous 6 months Baseline doppler study with a peak systolic velocity of 400cm/sec Patient is deemed candidate for carotid artery stenting TIMI flow of 1,2 or 3 80% or greater stenosis of distal common or internal carotid artery, as determined angiographically, as defined in ACAS Subjects are able to give informed consent Subjects are willing/able to complete follow-up visits Exclusion Criteria: History of major stroke: within the past 6 months History of Alzheimers disease or Dementia Unable or willing to complete the baseline and 20 days neuro-cognitive testing planned major surgery within the next 2 months Planned intervention opposite carotid artery within 2 months Ineligibility for carotid stent procedure due to anatomy, thrombus, or inability to complete anti-platelet therapy Any individual identified with cognitive impairment which would affect their performance during cognitive testing.

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| control and study group<br>severe carotid artery stenosis in asymptomatic patients defined as greater than 80% stenosis angiographically or greater than 400 cm/sec peak systolic velocity on carotid doppler evaluation | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| to determine the effect of carotid artery stenting, on cognitive function after carotid artery stenting in patients with severe carotid artery stenosis |  | 45 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| to evaluate the clinical benefit of carotid artery stenting on cognitive function, pre and post carotid artery stenting |  | 45 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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carotid stenting, cognitive function, pre and post stent, severe carotid artery stenosis