Optimization of the Acquisition Sequence to Improve the Quality and Comfort of Magnetic Resonance Imaging Exam

Study Overview
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Brief Summary
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The purpose of this study is to evaluate the optimization of MRI acquisition sequences.

Official Title
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Optimization of the Acquisition Sequence to Improve the Quality and Comfort of Magnetic Resonance Imaging Exam

Conditions
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Healthy Subjects, Patient Performing an MRI Examination

Intervention / Treatment
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* Other: MRI examination


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria for all subjects : to be over 18 year-old, to be able to understand the instructions given, to be enrolled in a social security plan, to have underwent a pre-inclusion medical examination, to give a written consent. Inclusion Criteria especially for Patients : to perform a MRI examination of the head, neck, spine, thorax, abdomen, pelvis, retroperitoneum, lower limbs, upper limbs or whole body during clinical follow-up care. Exclusion Criteria for all subjects : any contraindication to MR examination (active medical device, ferromagnetic foreign body, pregnancy, morbid obesity, claustrophobia, … ), subject under a measure of legal protection. Exclusion Criteria especially for Healthy Subjects : to have a pathology in the anatomical area to be imaged to be employed by the CHRU of Nancy or having the slightest link of subordination with the CHRU of Nancy. Exclusion Criteria especially for Patients : to have a limited MRI examination time due to a sensitive clinical situation (sedation, unstable hemodynamic state, postoperative).

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: All subjects will have an MRI examination<br> | Other: MRI examination<br>* All subjects (healthy subjects and patients) will have an MRI examination with optimized sequences<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Image quality based on standard imaging quality criteria. | The image quality will be appreciated visually at least by a radiologist or a researcher. | 6 months after the last inclusion | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of the Signal to Noise Ratio obtained by the optimized MRI sequence and the reference situation (standard sequence). | Signal to Noise Ratio will be measured in arbitrary units. | 6 months after the last inclusion | 
| Comparison of the Contrast to Noise Ratio obtained by the optimized MRI sequence and the reference situation (standard sequence). | Contrast to Noise Ratio will be measured in arbitrary units. | 6 months after the last inclusion | 
| Comparison of the acquisition time obtained with the optimized MRI sequence and the reference situation (standard sequence). | Time acquisition will be evaluated in minutes. | 6 months after the last inclusion | 
| Comparison of blurring and artefacts obtained by the optimized MRI sequence and the reference situation (standard sequence). | Absence of blurring and artefacts will be assessed by at least one radiologist according to an ordinal scale. | 6 months after the last inclusion | 
| Comparison of the spatial resolution obtained by the optimized MRI sequence and the reference situation (standard sequence). | Spatial resolution will be measured in mm². | 6 months after the last inclusion | 
| Qualification of the MRI acquisition for a clinical study. | Validation of MRI acquisition by a centralized review center. | 6 months after the inclusion | 
| Evaluation of intra-subject reproducibility on the same MRI and on two MRIs. | Measurement of intra-subject reproducibility on the same MRI and on two MRIs by the intra-class correlation coefficient for quantitative measurement or by the kappa coefficient for a qualitative measurement. | 6 months after the last inclusion |