Correlation Between Elastic Modulus of Ultrasonic Shear Wave and Tumor Stromal Component in Pancreatic Cancer

Study Overview
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Brief Summary
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Pancreatic cancer is a gastrointestinal tumor with a high degree of malignancy. Currently, there are many first-line chemotherapy regimens in clinical practice, but the individual selection of chemotherapy regimens has not been unanimously recognized.This study is aimed at exploring the correlation between the two-dimensional shear wave elastography (2D - SWE) parameters and pancreatic cancer stromal elements proportion through an ultrasound scan for resectable pancreatic cancer cases and postoperative pathological specimen analysis. Then determine if the pancreatic cancer two-dimensional shear wave elastography can guide clinicians selecting chemotherapy scheme by predicting tumor stromal elements .These results are expected to provide an effective non-invasive diagnostic basis for individualized treatment of pancreatic cancer.

Official Title
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Correlation Between Elastic Modulus of Ultrasonic Shear Wave and Tumor Stromal Component in Pancreatic Cancer

Conditions
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Pancreatic Neoplasms

Intervention / Treatment
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* Diagnostic Test: two-dimensional shear wave elastography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria Patients with resectable pancreatic cancer underwent ultrasound examination before surgery Conventional ultrasound can clearly show pancreatic space-occupying lesions and the elastic measurements show good images The patient agrees to receive ultrasound elasticity examination and signs informed consent All patients had no history of radiotherapy or chemotherapy before ultrasound examination All clinical case data and auxiliary examination data are complete and accessible. Exclusion Criteria Ultrasound evaluation was not performed before ultrasound-guided needle biopsy Conventional ultrasound could not clearly show pancreatic space-occupying lesions or poor elastic measurement images Patients who refuse to accept examination or give up treatment Patients receiving neoadjuvant chemotherapy or radiotherapy before ultrasound examination Incomplete clinical data and auxiliary examination data.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 100 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: two-dimensional shear wave elastography|Preoperative ultrasound elastography examination|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Elastic modulus measured by Ultrasonic shear wave and tumor stromal component assessed by pathological analysis in pancreatic cancer |  | Baseline (Preoperative ultrasound elastography examination) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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2D-SWE