Contamination of Bacillus Species Sepsis.

Study Overview
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Brief Summary
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Bacillus species are ubiquitous gram-positive spore-forming organisms. They rarely cause disease in the immunocompetent and are more frequently isolated as a culture contaminant. However, Bacillus Species can cause severe systemic infections in immunocompromised patients including preterm infants. The purpose of this study is to identify the risk factors of these infections.

Detailed Description
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Non-anthrax Bacillus Species bacteria can be responsible for food poisoning and local infections. Rarely, they lead to severe infections like blood stream infections and meningitis especially in immunocompromised patients like preterm infants. Bacillus Cereus is the most common members of the genus Bacillus. Only few reports studied these systemic infections in premature neonates. In order to identify the risk factors for severe Bacillus Species infections, we studied retrospectively eleven cases of these infections in our NICU and reviewed series and report cases in literature.

Official Title
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Contamination of Bacillus Species Sepsis.

Conditions
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Bacillus Cereus Infection

Intervention / Treatment
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* Diagnostic Test: Ways to prevent these infections.


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: cases of Bacillus Species sepsis cases of Bacillus species meningitis with significant change in clinical status Bacillus Species is the only organism isolated Exclusion Criteria: Bacillus Species isolated with other organisms and Bacillus Species without clinical change were considered to be contaminants

Ages Eligible for Study
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Maximum Age: 28 Days

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Premature neonates infected with bacillus Species<br>The investigators studied retrospectively eleven cases of these infections in our NICU and reviewed series and report cases in literature. | Diagnostic Test: Ways to prevent these infections.<br>* The purpose of this database is to describe the pathogenicity of this germ, the incriminated modes of contamination. The collaborators studied the factors of poor prognosis and propose ways to prevent these infections.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Severe infection rate due to Bacillus Sp germ | The purpose of this database is to mesure the pathogenicity of this germ based on the severe infection rate | Through study completion, an average of 1 year. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To collecte the incriminated modes of contamination. | The purpose of this database is to describe the incriminated modes of contamination. | Through study completion, an average of 1 year. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Bacillus Cereus, Premature neonates