linjc16/ctgov huggingface dataset:
Use Quantitative Microradiography to Predict the Periprosthetic Bone Loss in Distal Femur After Total Knee Arthroplasty

Study Overview
=================
Brief Summary
-----------------
The investigators hypothesized that the microarchitecture of bone influence the degree of periprosthetic bone loss after total knee arthroplasty surgery. The investigators collected the bone fragment at the distal femur while performing total knee replacement and take quantitative radiography analysis . Before and after the surgery(6 month ,12 month) , the investigators check the BMD at identical location of the distal femur by using dual energy absorptiometry. The investigators will use linear regression to evaluate the relationship between the microarchitecture and the degree of bone loss.

Official Title
-----------------
Use Dual-energy X-ray Absorptiometry and Quantitative Microradiography to Predict the Periprosthetic Bone Loss in Distal Femur After Total Knee Arthroplasty

Conditions
-----------------
Periprosthetic Bone Loss in Total Knee Replacement

Intervention / Treatment
-----------------
* Radiation: dual energy x-ray absorptiometry


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: severe knee osteoarthritis post menopausal women Exclusion Criteria: immune disease end stage of renal disease who receive dialysis history of fracture at ipsilateral distal femur

Ages Eligible for Study
-----------------
Minimum Age: 50 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| severe knee OA who are indicated for total knee arthroplasty<br>the woman who are indicated for TKR and are post menopausal will be recruited in this study. We will excluded the patients who had immune disease ,previous fracture of femur and end stage of renal disease | Radiation: dual energy x-ray absorptiometry<br>* before the surgery of total knee arthroplasty and after the surgery 6 months and 12 months<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change in bone mineral density | Use dual energy x-ray absorptiometry to detect to BMD at the distal femur | before the surgery and after the sugery (6month ,12month) | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
osteoarthritis, periprosthetic bone loss, dual energy x-ray absorptiometry
Study of Bioactive Glass-ceramic Intervertebral Spacer (Bonglass-SS) in Posterior Lumbar Interbody Fusion

Study Overview
=================
Brief Summary
-----------------
The goal of this study is to compare Bonglass-SS with titanum cage.

Official Title
-----------------
Clinical Efficacy and Safety of Bioactive Glass-ceramic Intervertebral Spacer (Bonglass-SS) in Posterior Lumbar Interbody Fusion and, Titanium Cage Controlled, 1-year, Single-Blind, Non-Inferiority Trial

Conditions
-----------------
Degenerative Disk Disease

Intervention / Treatment
-----------------
* Device: 4 CIS one-touch titanium cage
* Device: Bonglass-SS SSLPB


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 30 80 aged patients needed single-level posterior Interbody fusion at L1 S1 A subject who provided written informed consent to participate in this study Exclusion Criteria: Patitents with BMD T-score < -3.0 Women who are pregnant or plan to be pregnant within 3 years Patient with malignant tumor

Ages Eligible for Study
-----------------
Minimum Age: 30 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Control device<br> | Device: 4 CIS one-touch titanium cage<br>* 4 CIS one-touch titanium cage(Solco Biomedical Co. Ltd)<br>|
| Experimental: Investigational device<br> | Device: Bonglass-SS SSLPB<br>* Bonglass-SS SSLPB(BioAlpha Inc.)<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Radiographic assessments of fusion and instability at 12 months after surgery |  | 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| CT assessments of fusion at 12 months after surgery |  | 12 months |
Improved Patient Safety for Acute Restless Medical Patients With Supplemental Observation

Study Overview
=================
Brief Summary
-----------------
The aim of the study is to investigate whether supplemental camera observation directly linked to the nurse's phone will improve patient safety for acute medical care patients', who are restless, confused or in risk of development of acute delirium. The setting is an acute medical care ward. The expected result is a reduced incidence of patients with delirious condition, patients who fall or unintentionally remove intravenous access or catheters. Thus, higher patient safety and more efficient patient trajectories are expected, as well as a reduced need for treatment, care and rehabilitation after discharge.

Official Title
-----------------
Improved Patient Safety for Acute Restless Medical Patients With Supplemental Observation

Conditions
-----------------
Delirium

Intervention / Treatment
-----------------
* Device: Camera observation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients over 65 years of age with a CAM score of 2 or higher. Exclusion Criteria: paranoia severe dementia suicidal need for permanent guard

Ages Eligible for Study
-----------------
Minimum Age: 65 Years
Maximum Age: 100 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Sequential Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Camera observation<br>Camera observation | Device: Camera observation<br>* Supplemental camera observation directly linked to the nurse's phone<br>|
| No Intervention: No camera observation<br>No intervention | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Confusion Assessment Score | Assessed by Confusion Assessment Method (CAM) screening tool. Minimum value is 0, Maximum value is 4. Higher score means higher risk of developing Delirium. | First measurement at admission and second measurement within 24 hours. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patient falls | Incidence of patient falls observed by the nurse during the observation period. | The time the patient is assessed during the observation period. | 
| Discontinuation of accesses | Number of patient discontinuation of e.g. oxygen mask, peripheral venous catheter, bladder catheters | The time the patient is assessed during the observation period. | 
| Number of administrations of sedatives | Number of OR administrations and number of IV administrations (specific sedatives e.g. Methylphenidate, Haloperidol, Midazolam). | The time the patient is assessed during the observation period. |
Electric Impedance Tomography Before and After Dilatative Tracheotomy

Study Overview
=================
Brief Summary
-----------------
The changes of local pulmonary ventilation should be registered with an electric impedance tomography (EIT) before and after a dilatative tracheotomy. The hypothesis is that the EIT cannot show changes in local ventilation due to the tracheotomy.

Official Title
-----------------
EIT: Changes of Pulmonary Ventilation Before and After Tracheotomy

Conditions
-----------------
ICU Patients, Tracheotomy Required

Intervention / Treatment
-----------------
* Other: EIT belt


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: treatment on ICU indication for tracheotomy age between 18 and 85 years written to consent Exclusion Criteria: severe chronic pulmonary disease cardio pulmonary unstable situation

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| ICU patients undergoing a dilatative tracheotomy.<br> | Other: EIT belt<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| volume of ventilation, regional compliance. | measurement starts twenty minutes before surgery and ends after realised recruitment after tracheotomy. | Change from Baseline (2 Minutes preoperative) until 2 Minutes postoperative |
Fitness Training in Children

Study Overview
=================
Brief Summary
-----------------
We hypothesize that improvement in cardiovascular fitness is associated with a greater improvement in insulin sensitivity than improvement in body composition (loss of body fat) is associated with insulin sensitivity. Towards that we are randomizing children who are overweight, or children with low fitness levels to exercise intervention 2 or three times per week.

Official Title
-----------------
Effect of Fitness Training on Insulin Sensitivity and Body Composition in Children

Conditions
-----------------
Obesity, Low Fitness

Intervention / Treatment
-----------------
* Behavioral: exercise


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: obesity low fitness Exclusion Criteria: diagnosis of diabetes inability to exercise

Ages Eligible for Study
-----------------
Minimum Age: 7 Years
Maximum Age: 16 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: exercise|this will test the effect of exercise on insulin sensitivity, fitness and body composition|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| maximal VO2 levels |  | 9 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| fasting insulin and glucose levels |  | 9 months |
Evaluation of Reliability of the Near-infrared Imaging System (VistaCam iX Proxi) in Comparison With Digital Radiographic Findings and ICDAS-II in Detection of Approximal Carious Lesions.

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to evaluate the Clinical performance of the near-infrared imaging system VistaCam iX Proxi in comparison with digital radiographic findings and ICDAS-II in detection of approximal carious lesions.

Official Title
-----------------
Evaluation of Validity of the Near-infrared Imaging System (VistaCam iX Proxi) in Comparison With Digital Radiographic Findings and ICDAS-II in Detection of Approximal Carious Lesions: Diagnostic Accuracy Study.

Conditions
-----------------
Proximal Dental Caries

Intervention / Treatment
-----------------
* Device: Vistacam
* Radiation: Bitewing radiograph


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients aged from 18 to 40 years. No gender restriction. Patients should have an acceptable oral hygiene level. Patients must have at least one posterior proximal caries Exclusion Criteria: Patients with a compromised medical history. Severe or active periodontal disease. Heavy bruxism or a traumatic occlusion. Acute or chronic dental infection. Pregnant or breastfeeding women. Patients with posterior restorations on molars or premolars

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Interventional Model Description: screening of the Patients who join the Conservative Dentistry Department clinic will be done until the target population is achieved. The Patients' teeth will be subjected to visual examination and diagnosis using dental charts. once the patient is eligible to be included in this study, they will be contacted by the research investigator who will explain the study and identify the patient interests .If the patient show interest ,further clarification and discussing wil be held .
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: ICDAS II<br>Visual tactile examination based on ICDASII scoring system | Device: Vistacam<br>* device for early proximal caries detection<br>Radiation: Bitewing radiograph<br>* radiograph for proximal caries detection<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| dental caries | hidden proximal caries | through study completion, an average of 1 year |
Effectiveness of YNSA Acupuncture on Brain Networks

Study Overview
=================
Brief Summary
-----------------
This study investigates the effects of a new form of acupuncture (Yamamoto's New Skull Acupuncture [YNSA]) on resting-state brain networks. Therefore, two resting-state fMRI scans are measured (one without and one with acupuncture needles) in healthy adults. It is expected that acupuncture is associated with changes in functional connectivity within different brain networks.

Detailed Description
-----------------
Although acupuncture has been used in China and Japan for over 2000 years, it has only become increasingly important in Western medicine in the last few decades. A special form of acupuncture is Yamamoto's New Skull Acupuncture (YNSA), which was developed by Toshikatsu Yamamoto. Here, the needling is limited to the skull. Acupuncture is a safe and almost painless procedure that is usually well tolerated. One indication might be the therapy of neurological diseases. Schockert and colleagues examined the effectiveness of YNSA in a placebo-controlled study. To investigate the effectiveness of cranial acupuncture, three fMRI sequences were performed: 1) without acupuncture, 2) sham acupuncture (acupressure without needling) and 3) YNSA acupuncture. The subjects (17 stroke patients with right hemisphere lesions and 19 healthy controls) were instructed to alternately make a fist (3s) and close it again (2s). There were a total of five blocks, each with a duration of 120s. Compared to sham acupuncture, cortical activations in motor, premotor and supplementary motor areas were observed during YNSA acupuncture. In contrast to Schockert and colleagues, the planned study uses resting-state fMRI to determine whether YNSA acupuncture is associated with changes of functional connectivity within different resting-state networks.

Official Title
-----------------
Effectiveness of Yamamoto's New Skull Acupuncture (YNSA) on Resting State Brain Networks

Conditions
-----------------
Acupuncture

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: adults aged 18 to 65 Exclusion Criteria: mental disorders (dementia, depression) MRI contraindications claustrophobia weight > 120 kg

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changed functional connectivity | Functional connectivity is measured using resting-state fMRI. | 35 minutes | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Resting-state fMRI
Long-term Outcomes and Life Satisfaction of Adults With Pediatric-Onset Spinal Cord Injuries

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to assess life satisfaction and long-term outcomes (i.e., medical and psychosocial) of adults who sustained spinal cord injuries (SCI) as children or adolescents.

Detailed Description
-----------------
The ultimate goal of rehabilitation for children and adolescents with spinal cord injuries (SCIs) is to assure that they can grow up to have as productive and satisfying lives as their peers. Understanding factors associated with these outcomes of our patients after they have become adults may help to identify interventions and rehabilitation strategies that will optimize long-term outcomes. Long-term studies of adults with pediatric-onset SCI are needed to identify important outcomes, including survival, participation, health status and health-related quality of life, and life-satisfaction. Further, these outcomes need to be compared to population norms. Predictive models of important outcomes will be developed using independent factors, including demographic, impairment, functional limitation, participation, and environmental and personal factors. In addition, the impact of age at injury, upper extremity reconstruction or functional electrical stimulation implants, and the Mitrofanoff procedure on adult outcomes will be assessed. The stability of selected outcomes in comparison to normative and census data will be determined and factors associated with changes in these outcomes will be assessed.

Official Title
-----------------
Long-term Outcomes and Life Satisfaction of Adults With Pediatric-Onset Spinal Cord Injuries

Conditions
-----------------
Spinal Cord Injuries

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Individuals who are 19 years of age and older Were injured at the age of 18 years or younger Received care at Shriners Hospitals for Children in Chicago, Philadelphia, or Northern California Exclusion Criteria: Non-English speaking individuals due to lack of measures in languages other than English and lack of foreign-speaking research assistants severe brain injury

Ages Eligible for Study
-----------------
Minimum Age: 19 Years
Maximum Age: 100 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Adults with pediatric-onset SCI<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| medical complications | Assessment of medical complications, including pressure ulcers, spasticity, UTIs, hospitalizations | annually | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| psychological outcomes | assessment of current psychological functioning, including depression, anxiety, happiness, and life satisfaction | annually |
Radiocontrast Media Induced Hyponatremia

Study Overview
=================
Brief Summary
-----------------
Osmolality of contrast media can be resulted in translocational hyponatremia after percutaneous coronary intervention.

Detailed Description
-----------------
Radiocontrast media after percutaneous coronary interventioncan lead to increased osmolaliry of plasma, which results in translocational hyponatremia. The investigator will exam the incidence of hyponatremia after percutaneous coronary intervention, and will evaluate the underlying mechanism related to hyponatremia including translocational hyponatremia, or osmotic natriuresis.

Official Title
-----------------
Radiocontrast Media Induced Hyponatremia After Percutaneous Coronary Intervention: Observational Study

Conditions
-----------------
Percutaneous Coronary Intervention

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients who receive contrast media during percutaneous coronary intervention Exclusion Criteria: Patients who have sensitivity to contrast media. Liver cirrhosis Hypothyroidism SIADH Patients who receive IVIG or mannitol.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| GFR >= 60<br>MDRD eGFR 60 or more | |
| GFR <60<br>Under MDRD eGFR 60 | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of contrast media induced translocational hyponatremia | The will investigator evaluate how often translocational hyponatremia may develop after percutaneous coronary intervention. | 01/10/2010-28/02/2011 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Renal function is affected by the incidence of translocational hyponatremia. | Reduced renal function and urine output contribute the development of contrast media induced translocational hyponatremia. | 01/10/2010-28/02/2011 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Radiocontrast media,, hyponatremia