Epileptic Seizures in Intensive Care Units

Study Overview
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Brief Summary
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This retrospective observational cohort study is to assess and analyze clinical, electroencephalographic, laboratory, comorbidity, and treatment characteristics of Intensive care unit (ICU)-patients with epileptic seizures and to subsequently compare their characteristics with ICU-patients with status epilepticus (SE).

Detailed Description
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The aim of this retrospective observational cohort study is to get further insight into adult patients with epileptic seizures in ICUs in an academic tertiary medical care center regarding frequency, clinical and electroencephalogram (EEG) characteristics, treatment, course and outcome. This data could help understanding the epidemiology (including risk factors, influence of EEG), and to guide management and improve outcomes of affected patients.

Official Title
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Epileptic Seizures in Intensive Care Units

Conditions
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Epileptic Seizure

Intervention / Treatment
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* Other: collection of patient data


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: admitted to the ICU at the University Hospital Basel suffered from one or more epileptic seizures (detected clinically and/or by EEG) during their ICU-stay Exclusion Criteria: patients with epileptic seizures transforming into Status epilepticus (SE)

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: collection of patient data|Patient data will be collected using the in-house digital patient record systems and the local digital electroencephalogram (EEG)-database|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Frequency of epileptic seizures | Frequency of all epileptic seizures in the ICU | between 01.01.2005 and 19.12.2018 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of epileptic seizures captured by EEG | Number of epileptic seizures captured by EEG without overt clinical seizure presentation in the ICU | between 01.01.2005 and 19.12.2018 | 
| Number of epileptic seizures diagnosed on the basis of clinical symptoms alone | Number of epileptic seizures diagnosed on the basis of clinical symptoms alone in the ICU | between 01.01.2005 and 19.12.2018 | 
| Length of epileptic seizure (time) | Duration of epileptic seizure | between 01.01.2005 and 19.12.2018 | 
| Semiological feature of epileptic seizure (i.e. seizure types) | Semiological feature of epileptic seizure (i.e. seizure types) emerging in ICU-patients | between 01.01.2005 and 19.12.2018 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Status epilepticus, Electroencephalogram, Intensive Care Unit