Cementless One-stage Revision of the Chronic Infected Hip Arthroplasty

Study Overview
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Brief Summary
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The investigators hypothesise that cementless one-stage exchange revision surgery can be performed in patients with chronically infected hip replacement with substantial benefits for the patients, in terms of fast rehabilitation, low re-revision rates and good long term results.

Official Title
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Cementless One-stage Revision in Fast-track Setting of the Chronic Infected Hip Arthroplasty

Conditions
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Infection, Hip Joint Replacement

Intervention / Treatment
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* Procedure: Cementless one-stage surgical revision


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient with clinical signs of infection for more than 4 weeks, arising from total hip arthroplasty (primary and revision), resurfacing hip arthroplasty or hemi-hip arthroplasty Informed oral and written consent given Exclusion Criteria: Life expectancy under 2 years Cognitive dysfunction Pre-operative unwillingness to receive blood Intravenous drug abuse Alcoholism Immunocompromised patients Patients receiving immunosuppressive medication Ongoing systemic inflammatory disease Poorly regulated diabetes mellitus Renal failure (requiring dialysis) Acute systemic inflammatory response syndrome with proven infection (sepsis) Signs of coexisting active long-term local infection (i.e. endocarditis) Previous two-stage revision of hip arthroplasty due to ipsilateral chronic infection (regardless of symptom free interval) or contralateral chronic infection (within the last 2 years). < 6 weeks since last surgery of the affected hip If definition of infection is not fulfilled: infection defined as Culture positive: ≥ 3 positive intraoperative cultures (tissue biopsies a.m. Kamme-Lindberg) Culture negative: < 3 positive intraoperative cultures (tissue biopsies a.m. Kamme-Lindberg) + Chronic fistula with history of previous or existing secretion or Positive cultures in pre-operatively joint fluid aspiration with other clinical signs of infection or Visual pus or purulent fluid during exchange procedure with clinical signs of infection

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Surgical revision<br>Surgical cementless One-stage revision of the chronic infected hip arthroplasty | Procedure: Cementless one-stage surgical revision<br>* A Cementless one-stage surgical revision is to be performed for all included in the cohort.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| re-infection |  | 2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Revision for other cause than infection |  | 2 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Chronic infected hip arthroplasty, Fast-track, One-stage cementless revision