Influenza Vaccination, ACEI and ARB in the Evolution of SARS-CoV2 Infection

Study Overview
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Brief Summary
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Some authors have proposed the use of the flu vaccine to reduce the severity of COVID-19 cases, while some have proposed the use of ACE Inhibitors (ACEI) or Angiotensin Receptor blockers (ARB), since this virus shares hemagglutinin as a transmission mechanism and acts on the ACE2 enzyme during infection. Other authors described how none of the elderly patients receiving antihistamines and azythromycin in two nursing homes in Toledo -Spain- during the first wave died or needed hospital admission, even considering that 100% of residents had a positive serological test after that wave. Other authors have described a positive evolution in patients receiving amantadine for their Parkinson's disease. The aim is to evaluate whether the admitted patients who are previously vaccinated or those who were already receiving these treatments showed a better evolution.

Detailed Description
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The number COVID cases would be related to hospital admissions. Among hospital admissions, the number of previous treatments, the length of admission, the need or not of the Intensive Care Unit (ICU) and their final status (survivors or non survivors) would be studied. If patients that previously received the influenza vaccine or treated with ACEI, ARB, antihistamines or amantadine showed a better evolution, it would be proposed to extend vaccination and the inclusion of ACE inhibitors, ARB, antihistamines or amantadine in the treatment of infection.

Official Title
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Evaluation of Influenza Vaccination and Treatment With ACEI and ARB in the Evolution of SARS-CoV2 Infection

Conditions
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ARB, COVID19, Influenza Vaccination, ACE Inhibitors, Antihistamine Allergy, Amantadine

Intervention / Treatment
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* Drug: Antihistamine
* Drug: Amantadine
* Drug: ACEI
* Drug: ARB
* Other: Influenza vaccine and COVID


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Hospital Admissions at the Hospital of Terrassa from March 1, 2020 for any cause. Exclusion Criteria: None. For comparison of percentage of Influenza vaccination, ACEI and ARB vs general population, patients from outside the reference area of the Terrassa Health Consortium would be excluded.
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Hospital admissions among COVID cases in the assigned population of the Terrassa Health Consortium<br>Observation of patient characteristics of hospital incomes in Hospital of Terrassa from March 1, 2020. No intervention is performed. | Drug: Antihistamine<br>* No intervention is performed. We propose an observational study.<br>* Other names: Antihistamines for COVID;Drug: Amantadine<br>* No intervention is performed. We propose an observational study<br>* Other names: Amantadine for COVID;Drug: ACEI<br>* No intervention is performed. We propose an observational study.<br>* Other names: ACEI and COVID;Drug: ARB<br>* No intervention is performed. We propose an observational study.<br>* Other names: ARB and COVID;Other: Influenza vaccine and COVID<br>* No intervention is performed. We propose an observational study.<br>|
| Evolution of COVID cases in patients receiving antihistamines<br>COVID cases, hospital admissions and deaths related to COVID from march 1, 2020 in patients of the participating institutions receiving chronic treatment with antihistamines. No intervention is performed. | Drug: Antihistamine<br>* No intervention is performed. We propose an observational study.<br>* Other names: Antihistamines for COVID;|
| Evolution of COVID cases in patients receiving amantadine.<br>COVID cases, hospital admissions and deaths related to COVID from march 1, 2020 in patients of the participating institutions receiving chronic treatment with amantadine. No intervention is performed. | Drug: Amantadine<br>* No intervention is performed. We propose an observational study<br>* Other names: Amantadine for COVID;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| hospital output | exitus vs hospital output | from March 1, 2020. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| hospital stay | length of the hospital stay | From March 1, 2020. |