Effectiveness of a Buteyko-based Breathing Technique for Asthma Patients

Study Overview
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Brief Summary
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The purpose of this study is to investigate the effects of a Buteyko-based breathing technique on physiological and psychological parameters in adults with asthma

Detailed Description
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The investigators explore the effects of a Buteyko-based breathing technique training using a treatment group vs. control group design and a repeated measures design with follow-up measurements 3 and 6 months after the intervention. The sample size calculation was made for an effect of d = .20 with repeated measures, a power of 1- β = .80 and α = .05. Additionally the investigators plan to take measurements (only once) from healthy volunteers matching them (age and gender) with the asthma patients.

Official Title
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Effectiveness of a Buteyko-based Breathing Technique on Psycho-physiological Parameters of Adults With Asthma - a Randomized, Controlled Study

Conditions
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Asthma

Intervention / Treatment
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* Other: Buteyko Breathing Technique


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Written informed consent, regular intake of prescribed asthma medication according to the AWMF scheme level 1, native speaker of german Exclusion Criteria: Participation in another study, comorbidities (heart diseases, cancer still under treatment, psychiatric diseases)

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Buteyko Training<br>Breathing exercises according to the Buteyko Breathing Technique | Other: Buteyko Breathing Technique<br>* Patients are trained in various exercises aiming at breath reduction and breath control as introduced by Dr. K. Buteyko<br>|
| No Intervention: Control Group<br>Standard care as usual | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Endtidal CO2 | Capnometry | Between baseline and 3 month follow up | 
| Change in Nijmegen-Score | Questionnare assessing hyperventilation | Between baseline and 3 month follow up | 
| Change in Buteyko CP | Breath hold test | Between baseline and 3 month follow up | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Spirometry: FEV1 | FEV1 | Between baseline and 3 month follow up | 
| Spirometry: FEV1 | FEV1 | Between baseline and 6 month follow up | 
| Spirometry: FEV1/VCin | FEV1/VCin | Between baseline and 3 month follow up | 
| Spirometry: FEV1/VCin | FEV1/VCin | Between baseline and 6 month follow up | 
| Spirometry: PEF | PEF | Between baseline and 3 month follow up | 
| Spirometry: PEF | PEF | Between baseline and 6 month follow up | 
|  | Oral exhaled Nitric oxide | Between baseline and 3 month follow up | 
|  | Oral exhaled Nitric oxide | Between baseline and 6 month follow up | 
| Heart Rate Variability (SDNN) | SDNN | Between baseline and 3 month follow up | 
| Heart Rate Variability (SDNN) | SDNN | Between baseline and 6 month follow up | 
| Heart Rate Variability (RMSSD) | RMSSD | Between baseline and 3 month follow up | 
| Heart Rate Variability (RMSSD) | RMSSD | Between baseline and 6 month follow up | 
| Heart Rate Variability (LF/HF) | LF/HF | Between baseline and 3 month follow up | 
| Heart Rate Variability (LF/HF) | LF/HF | Between baseline and 6 month follow up | 
| Vascular stiffness | Pulse Wave Velocity | Between baseline and 3 month follow up | 
| Vascular stiffness | Pulse Wave Velocity | Between baseline and 6 month follow up | 
| Blood Pressure | Systolic and Diastolic | Between baseline and 3 month follow up | 
| Blood Pressure | Systolic and Diastolic | Between baseline and 6 month follow up | 
| Haemodynamics Stroke volume | Stroke volume | Between baseline and 3 month follow up | 
| Haemodynamics Stroke volume | Stroke volume | Between baseline and 6 month follow up | 
| Haemodynamics Cardiac output | Cardiac output | Between baseline and 3 month follow up | 
| Haemodynamics Cardiac output | Cardiac output | Between baseline and 6 month follow up | 
| Haemodynamics Total Vascular Resistance | Total Vascular Resistance | Between baseline and 3 month follow up | 
| Haemodynamics Total Vascular Resistance | Total Vascular Resistance | Between baseline and 6 month follow up | 
| Haemodynamics Cardiac index | Cardiac index | Between baseline and 3 month follow up | 
| Haemodynamics Cardiac index | Cardiac index | Between baseline and 6 month follow up | 
| Haemodynamics Perfusion | Perfusion index | Between baseline and 3 month follow up | 
| Haemodynamics Perfusion | Perfusion index | Between baseline and 6 month follow up | 
| Haemodynamics Plethvariability | Plethvariability index (PVI) | Between baseline and 3 month follow up | 
| Haemodynamics Plethvariability | Plethvariability index (PVI) | Between baseline and 6 month follow up | 
| Oxygen Saturation | SpO2 | Between baseline and 3 month follow up | 
| Oxygen Saturation | SpO2 | Between baseline and 6 month follow up | 
| ACQ | Asthma Control Questionnaire, E. Juniper | Between baseline and 3 month follow up | 
| ACQ | Asthma Control Questionnaire, E. Juniper | Between baseline and 6 month follow up | 
| AQLQ | Asthma Quality of Life Questionnaire, E. Juniper | Between baseline and 3 month follow up | 
| AQLQ | Asthma Quality of Life Questionnaire, E. Juniper | Between baseline and 6 month follow up | 
| ARCIM Questionnaire | Questionnaire focusing on respiratory complaints like mucus, snoring, blocked nose. | Between baseline and 3 month follow up | 
| ARCIM Questionnaire | Questionnaire focusing on respiratory complaints like mucus, snoring, blocked nose. | Between baseline and 6 month follow up | 
| STAI Questionnaire | State and Trait Anxiety Inventory | Between baseline and 3 month follow up | 
| STAI Questionnaire | State and Trait Anxiety Inventory | Between baseline and 6 month follow up | 
| ASF Questionnaire | Aachener Selbstwirksamkeitsfragebogen | Between baseline and 3 month follow up | 
| ASF Questionnaire | Aachener Selbstwirksamkeitsfragebogen | Between baseline and 6 month follow up | 
| Asthma medication | Kind and dosage of asthma specific medication like steroids or betamimetics | Between baseline and 3 month follow up | 
| Asthma medication | Kind and dosage of asthma specific medication like steroids or betamimetics | Between baseline and 6 month follow up | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Buteyko-based breathing technique training