Orientation Agnosia: Clinical and Anatomical Study

Study Overview
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Brief Summary
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The area of the brain responsible of visuospatial processing data and more specifically the orientation of an object or image is located in parietal lobe, especially on the right side. A dysfunction of this region would result in a disorder of recognition of the orientation of objects and images that the investigators call orientation agnosia. Several isolated cases are reported in the literature but to the investigators knowledge deficit has never been systematically searched, or put into perspective compared to other neuropsychological deficits. Moreover, the precise location of the lesion responsible for such a disorder remains uncertain. The objectives of this study are (1) detect the existence of orientation agnosia in case of right parietal lesion, and (2) to improve the understanding of such a deficit allowing better management of this disorder.

Detailed Description
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Idem

Official Title
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Orientation Agnosia: Neuropsychological Evaluation, Associated Symptoms, Clinical and Anatomical Correlations

Conditions
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Cerebrovascular Disorders, Brain Lesions

Intervention / Treatment
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* Behavioral: Neuropsychological testing
* Other: MRI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age between 18 and 80 years french language right parietal lesion on cerebral imaging (CT-scan is sufficient), including stroke,arterial malformation, isolated tumoral lesion informed consent Exclusion Criteria: previous neurological history except non complicated migraine and stabilized epilepsia without seizure since 5 years previous psychiatric history except depression without hospitalization > one week or anxiety with maximum one anxiolytic treatment drug or alcohol abuse severe cranial traumatism other severe chronic pathology psychotropic medication other than a hypnotic or an anxiolytic at low doses without dose modification for at least one month visual impairment motor or sensory deficit sufficient to render impossible neuropsychological tests patient without judicial or administrative liberty measure of legal protection or no capable to express their consent pregnancy or breastfeeding

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Screening
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: patient with right parietal lesions<br> | Behavioral: Neuropsychological testing<br>* Experimental test about orientation agnosia and standard neuropsychological tests.<br>Other: MRI<br>* Cerebral MRI<br>|
| Active Comparator: patient with left parietal lesions<br> | Behavioral: Neuropsychological testing<br>* Experimental test about orientation agnosia and standard neuropsychological tests.<br>Other: MRI<br>* Cerebral MRI<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| orientation agnosia evaluation | orientation agnosia test | 1 week to 6 months (average) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| associated clinical symptoms especially apraxia |  | 1 week to 6 months (average) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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stroke, parietal lesions