Influencing Factors of Coronary Heart Disease in Young People

Study Overview
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Brief Summary
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The incidence of coronary heart disease in young people is not uncommon and the investigators will explore the factors contributing to this outcome

Detailed Description
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Through the multi-center clinical research conducted by several units in Nantong city, the risk factors and aggregation of the incidence of CHD among young people in nantong city were obtained, so as to fill in the blank of domestic multi-center research and reduce the incidence of CHD among young people.The investigators will conduct a long-term follow-up study on the young patients with CHD to screen the factors contributing to the poor prognosis of CHD in young patients.The investigators will fill this gap and intervene early to improve patients' quality of life and prolong their survival

Official Title
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To Study the Risk Factors of Youth Coronary Heart Disease From Inflammatory Cytokines，Lifestyle and Familial Inheritance

Conditions
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Coronary Heart Disease

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosed coronary heart disease Confirmed by coronary angiography Diagnosed myocardial infarction Willing to sign an inform consent Exclusion Criteria: Patients won't sign an inform consent or will not comply with the follow up.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Normal young<br>Aged less than 45 years old,no underlying heart disease | |
| Young people diagnosed with coronary heart disease<br>Aged less than 45 years old,Diagnosed coronary heart disease;Confirmed by coronary angiography;Diagnosed myocardial infarction;Typical symptom of ischemic chest pain with positive stress test; | |
| Coronary heart disease<br>Older than 65 years, diagnosed with coronary heart disease | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Whether inflammatory factors are differentially expressed in young patients with coronary heart disease | The Investigators will analyze blood samples from the participants to see if there was a difference in the expression of inflammatory factors with high correlation compared with the control group by ELESA and High-throughput sequencing. | Until April 2024 | 
| The effect of gene activity on youth morbidity | The investigators will use enrichment analysis to screen the target genes and sequence the participants.Whether the target gene was expressed at high levels in the participants.And the investigators will further analyze the target gene | Until April 2024 | 
| Sedentary, high-fat diet, lack of exercise and other unhealthy lifestyle effects on young people | The researchers will retrospectively examine the participants' negative lifestyle habits, such as sedentary behavior, smoking, high-fat diet, and lack of exercise, in combination with their coronary angiography results | Until April 2024 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Coronary heart disease, Inflammatory cytokines, lifestyle, Familial inheritance, Myocardial infarction