Adjunctive Role of PRF After Free Gingival Graft Harvesting - Case Series

Study Overview
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Brief Summary
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Free gingival grafts are important to increase zone of attached gingiva and root coverage. This case series reveals role of platelet-rich fibrin (PRF) as adjunctive therapy in palatal wound healing. The superior healing observed at the PRF membrane sites supports its use in accelerating soft-tissue healing. PRF membrane as a palatal bandage is an efficacious approach to protect the raw wound area of a palatal donor site to reduce healing time and patient discomfort.

Detailed Description
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Introduction: Free gingival grafts are one of the common treatment modalities used to increase the zone of keratinized tissue (KT) around implants or prior to ridge augmentation and root coverage. The palatal donor sites had many complications as pain, discomfort and healing by secondary intention. Platelets Rich Fibrin (PRF) is a second generation of platelets concentrate full of growth factors fasten the healing and decrease the pain. Materials and methods: Ten patients requiring augmentation of KT participated in this case series. The palatal donor sites of 7 of these patients were covered with PRF membranes with a new suturing technique without palatal stent, the other 3 had palatal stent. Palatal tissue will examined clinically after 3, 7, 10 and 14 days. Considerably very fast healing with 0 pain score was observed during one week in the group with PRF.

Official Title
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Adjunctive Role of Platelets Rich Fibrin in Palatal Wound Healing After Free Gingival Graft Harvesting - Case Series

Conditions
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Platelets Rich Fibrin, Palatal Donor Tissue

Intervention / Treatment
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* Biological: Platelets Rich Fibrin in healing of palatal donor tissue
* Other: Placebo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Systemic free, Good oral hygiene and insufficient attached gingiva prior to ridge augmentation Exclusion Criteria: High arched palate, medically compromised

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: PRF<br>Platelets Rich Fibrin | Biological: Platelets Rich Fibrin in healing of palatal donor tissue<br>* Platelets Rich Fibrin (PRF) is a second generation of platelets concentrate full of growth factors as PDGF, IGF, TGF which had a role in hemostasis fasten the healing and decrease the pain.<br>|
| Placebo Comparator: palatal stent<br>Palatal stent | Other: Placebo<br>* the other group is a control group, had no biologic in the palatal wound, only palatal stent<br>* Other names: Palatal stent;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain Assessment by Visual Analog Scale (VAS) | VAS ranged from 0 (no pain ) to 10 (severe pain) | 1 week postoperative | 
| Clinical healing of the palate | color match, consistency and thickness of palate (Composite measure) | 2 weeks postoperative |