Efficacy of Cognitive Bias Modification in Residential Treatment for Addiction

Study Overview
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Brief Summary
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The purpose of this study is to determine whether computer bias modification for interpretation bias (CBM-I) is effective in the reduction of suicidal ideation in substance use disorders.

Detailed Description
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Eighty-eight adult inpatients completing residential treatment in the Addictions Services at the Centre for Addiction and Mental Health (CAMH) will be randomized to receive CBM-I daily for one week, adjunct to the residential psychosocial treatment or to an assessment-only control condition. Participants will complete clinical measures consisting of interviews and questionnaires measuring suicidal ideation, hopelessness, depression, negative affect, and interpretation biases before, during and after treatment.

Official Title
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Efficacy of Cognitive Bias Modification in Residential Treatment for Addiction

Conditions
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Substance Dependence

Intervention / Treatment
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* Behavioral: Cognitive Bias Modification


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Exhibit moderate suicide risk or greater Be enrolled in the Addictions Services inpatient program Fluent in reading English Capacity to give informed consent Exclusion Criteria: A lifetime diagnosis of a psychotic or bipolar disorder Significant neurological disorder or psychical illness likely to interfere with participation Psychotropic medication changes within the past two weeks

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Cognitive Bias Modification<br>64 training paragraphs, approximately 10-20 seconds each, digitally recorded and presented stereophonically through headphones, delivered over the course of one week. | Behavioral: Cognitive Bias Modification<br>* Training paragraphs describe scenarios designed to be ambiguous at the outset and to resolve in a positive direction, with the intention of establishing a learning contingency between the ambiguity at the beginning of the scenario and the positive resolution that becomes clear towards the end of the statement.<br>|
| No Intervention: Assessment-Only Control<br>No training will be provided. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Columbia-Suicide Severity Rating Scale, Screen Version (C-SSRS) | This scale quantifies the severity of suicidal ideation and behaviour. | Seven days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Beck Hopelessness Scale (BHS) | This questionnaire assesses thoughts and emotions associated with the future. | Seven days | 
| Beck Depression Inventory II (BDI-II) | This questionnaire assesses severity of depressive symptoms and cognitions. | Seven days | 
| Positive and Negative Affect Schedule (PANAS) | This questionnaire assesses current positive and negative mood | Seven days | 
| Scrambled Sentences Tests | This computer test will be used as an implicit measure of negative interpretation bias. | Seven days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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cognitive bias modification, interpretation bias, suicidal ideation, depression