Fibromyalgia in Patient With Impaired Fasting Glucose

Study Overview
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Brief Summary
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To assess the frequency of fibromyalgia among women with impaired fasting glucose.

Detailed Description
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Objective: To assess the frequency of fibromyalgia among women with impaired fasting glucose. Materials and Methods: The sample was selected from the patients who applied to the Internal Medicine clinic and whose fasting blood glucose level were ≥100 and <126 mg/dL in their routine examination [Group1 ] and patients whose fasting blood glucose were less than 100 constituted the control group [Group2 ]. Oral glucose tolerance test [OGTT ] has been applied to patients with impaired fasting glucose and whose 2nd hour OGTT levels were under 140 has been included. Patients were evaluated in terms of fibromyalgia according to modified 2010 ACR Fibromiyalgia Criteria. Functional status was assessed by using the Fibromyalgia Impact Questionnaire [FIQ ].

Official Title
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Fibromyalgia in Patient With Impaired Fasting Glucose

Conditions
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Fibromyalgia

Intervention / Treatment
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* Diagnostic Test: oral glucose tolerance test (OGTT)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: the study group subjects: fasting blood glucose level was between 100 and 126 mg/dL; the control group subjects: fasting blood glucose level was < 100 mg/dL. Exclusion Criteria: Patients with a severe systemic disease (chronic kidney disease, liver disease etc. ), psychiatric disease, hypothyroidism or hyperthyroidism, any connective tissue disease patients who used medications that influenced the fibromyalgia symptoms, such as analgesics, antidepressants, and anticonvulsive medications

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental group<br>Experimental group subjects with impaired fasting glucose (IFG) (Group 1) underwent an oral glucose tolerance test (OGTT), and patients with levels > 140 mg/dL at the 2nd hour were excluded because they were diagnosed with impaired glucose tolerance | Diagnostic Test: oral glucose tolerance test (OGTT)<br>* Implementation of OGTT: The patient was seated in a quiet room after 10-12 h of overnight fasting, and blood samples were drawn. Thereafter, 75 g glucose solution dissolved in 300 mL of water was administeredwithin 5 min. Two hours after this,another blood sample was drawn. During the test, the patient wasn't allowed to rest and eat, but not smoke.<br>|
| control group<br>The control group (Group 2) comprised 73 patients whose fasting blood glucose level was <100 mg/dL and who agreed to participate in the study. | Diagnostic Test: oral glucose tolerance test (OGTT)<br>* Implementation of OGTT: The patient was seated in a quiet room after 10-12 h of overnight fasting, and blood samples were drawn. Thereafter, 75 g glucose solution dissolved in 300 mL of water was administeredwithin 5 min. Two hours after this,another blood sample was drawn. During the test, the patient wasn't allowed to rest and eat, but not smoke.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the frequency of fibromyalgia among women with impaired fasting glucose. | Moreover, a significantly higher proportion of Group 1 patients (26%, n = 19) than Group 2 patients (11%, n = 8) were diagnosed with FM | 16 month |