Cardiac Magnetic Resonance Tomography for Heart Failure With Preserved Ejection Fraction

Study Overview
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Brief Summary
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The diagnosis of heart failure with preserved ejection fraction has so far been made primarily according to criteria determined by echocardiography, or invasively by measuring the left ventricular filling pressures. Increasingly, CMR is also evaluated with regard to the diagnosis of cardiac insufficiency with preserved pump function.However, it is still unclear which parameters can be used meaningfully for diagnostics.To answer this question, the investigators want to retrospectively evaluate data collected from patients with a clinical indication for CMR and coronary angiography.

Detailed Description
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Heart failure with preserved pump function is a common disease that is associated with a high level of suffering for the patient. The diagnosis has so far been made primarily according to criteria determined by echocardiography, or invasively by measuring the left ventricular filling pressures. With its high spatial resolution and the possibility of tissue-specific diagnostics, cardiac MRI (CMR) offers outstanding possibilities in cardiac imaging without exposing the patient to ionizing radiation. Increasingly, CMR is also evaluated with regard to the diagnosis of cardiac insufficiency with preserved pump function. However, it is still unclear which parameters can be used meaningfully for diagnostics. There is evidence for a correlation with invasively increased LVEDP, although the number of patients examined in the previous studies was still small. In addition, possible influences from medication and clinical parameters were not examined. To answer this question, the investigators want to retrospectively evaluate data collected from patients with a clinical indication. The significance of the study is that in the future CMR could supplement echocardiography in the diagnosis of HFpEF and further reduce the need for invasive diagnostics.

Official Title
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Diagnostic Accuracy of Cardiac Magnetic Resonance Tomography (CMR) for Heart Failure With Preserved Ejection Fraction (HFpEF)

Conditions
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Heart Failure, Diastolic

Intervention / Treatment
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* Diagnostic Test: CMR


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with CMR and left heart catheterization including LVEDP measurement within the same month Exclusion Criteria: Severe Valve Dysfunction or Pericardial/Pleural Disease Contraindictaion for CR or Cath

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: CMR|Clinically indicated cardiac magnetic resonance tomography executed according to international guideline recommendations.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Extracellular myocardial volume (%) | Estimated percentage of extracellular volume of the myocardium | One montth | 
| Left atrial volume (ml) | Volume of the left atrium in mililiters | One month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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cardiac magnetic resonance, magnetic resonance imaging, lvedp