Haloperidol and Dexamethasone Towards Postoperative Nausea and Pain in Adult After Laparoscopy

Study Overview
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Brief Summary
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This study aim to find out the effectiveness of 1 mg intravenous haloperidol compared to 5 mg intravenous dexamethasone to prevent the occurrence of nausea and vomiting also as pain control in adult patients after laparoscopic surgery.

Detailed Description
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Eighty subjects (n=40 for each group) scheduled for laparoscopic-assisted surgery were enrolled in a randomized double-blind clinical trial. One milligram intravenous haloperidol was given one hour before the end of surgery, while 5 mg intravenous dexamethasone was given right after induction. The occurrence of Postoperative Nausea and Vomiting (PONV) and visual analog scale (VAS) pain score were recorded.

Official Title
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Haloperidol Compared to Dexamethasone in Lowering Postoperative Nausea and Vomiting and Pain in Adult After Laparoscopy

Conditions
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Laparoscopy, Postoperative Nausea and Vomiting

Intervention / Treatment
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* Drug: Dexamethasone injection
* Drug: Haloperidol Injection


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: underwent laparoscopic surgery (gynecology, digestive, or urology surgery) American Society of Anesthesiologist (ASA) physical status 1-3 Exclusion Criteria: psychological or neurological disorders (routine haloperidol consumption) history of allergic reaction to dexamethasone or haloperidol diabetes mellitus did not give the consent

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Dexamethasone<br>5 mg intravenous dexamethasone | Drug: Dexamethasone injection<br>* Group A consisted of patients given 5 mg intravenous dexamethasone after induction.<br>* Other names: dexamethasone;|
| Active Comparator: Haloperidol<br>1 mg intravenous haloperidol | Drug: Haloperidol Injection<br>* Group B consisted of patients given 1 mg intravenous haloperidol one hour before the surgery ended<br>* Other names: haloperidol;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Nausea and Vomiting | Number of patients experiencing nausea and vomiting postoperative | Within 24 hours postoperative | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain and VAS | Visual Analog Scale (VAS) score, the minimum score is 0 and the maximum score is 10. The higher scores mean a worse outcome | 0-2 hours, 2-6 hours, 6-12 hours, and 12-24 hours postoperative | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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dexamethasone, haloperidol, nausea, pain, vomiting