Longitudinal Family/Molecular Genetic Study to Validate Research Domain Criteria

Study Overview
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Brief Summary
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The purpose of this research is to study new ways of classifying mental disorders in children based on observable behavior and genetics to ultimately diagnose these disorders better.

Detailed Description
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The NIMH Research Domain Criteria (RDoC) initiative seeks to further a long-range goal of contributing to diagnostic systems as informed by research on genetics, neuroscience, and behavior. The RDoC approach is based on identifying the most elemental units of analysis relevant to psychiatric disorders (such as genes and molecules) and using this matrix as a framework for investigation. In this case-control family study, the investigators will be using self-report questionnaires and computer-based tests to develop diagnostic methods for neuropsychiatric disorders in children, their siblings, and their parents. They will do this by recruiting normal and affected children, their siblings, and their parents. They will look at the subject, sibling, and parents to determine if psychiatric disorders are inherited. Affected children, ages 6-12, are those who have been diagnosed with a psychiatric disorder. Participants will undergo a battery of questionnaires/evaluations and a blood draw. The investigators will determine if the questionnaires and tests that reflect the constructs (such as reward prediction and willingness to work) predict psychopathology and impairment. The blood draw will be genotyped to determine if the measured constructs are associated with neuropsychiatric candidate genes, cross-disorder candidate gens and a cross-disorder polygenic score.

Official Title
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Longitudinal Family/Molecular Genetic Study to Validate Research Domain Criteria

Conditions
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Mental Disorders, Psychological Disorders, Psychiatric, Diagnosis, Mental Disorders Diagnosed in Childhood

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: male or female, ages 6-12. biological child of parent(s) participating in testing. Exclusion Criteria: taking psychotropic medications. free of uncontrolled medical problems. major sensorimotor disability (e.g., deafness, blindness). diagnosed neurological condition. inadequate command of the English language. history of head injury with loss of consciousness lasting longer than 10 minutes. IQ estimated at below 80.

Ages Eligible for Study
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Minimum Age: 6 Years
Maximum Age: 12 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Child Proband with Psychiatric Disorder<br>Affected group of child probands with psychiatric disorders (ages 6-12 years). | |
| Normal Comparison Group<br>Non-disordered psychiatrically normal comparison group (ages 6-12 years). | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Reward Valuation | Measures: Self-report, computerized tests, and DNA samples; Assessing correlations among family members and predictors of psychopathology. | Baseline | 
| Effort Valuation/Willingness to Work | Measures: Self-report, computerized tests, and DNA samples; Assessing correlations among family members and predictors of psychopathology. | Baseline | 
| Expectancy/Reward Prediction Error | Measures: Self-report, computerized tests, and DNA samples; Assessing correlations among family members and predictors of psychopathology. | Baseline | 
| Initial Responsiveness to Reward Attainment | Measures: Self-report, computerized tests, and DNA samples; Assessing correlations among family members and predictors of psychopathology. | Baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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children, mental health, family genetic study