Various Serving Sizes of Lentils on Blood Glucose and Insulin

Study Overview
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Brief Summary
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The purpose of this study is to assess the effects of consuming either 1/2 or 1/4 cup servings of lentils on post-prandial blood glucose and insulin as compared to 4 types of starchy foods (corn, macaroni, white potato, white rice).

Detailed Description
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Eligible participants will undergo a total of 6 study visits. During each visit, a fasted blood sample will be taken by fingerprick, and approximately 500 µL of blood will be dripped into a collection tube. The participant will then consume a meal of either: two types of lentils, corn, macaroni, white rice, or white potato. All study days will be randomized. Each meal will be served in either 1/4 or 1/2 cup servings depending on the study block. Six more blood samples will be taken by fingerprick at 15, 30, 45, 60, 90 and 120 minutes after the beginning of the meal.

Official Title
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The Effect of Various Serving Sizes of Lentils and Other Starchy Meals on Post Prandial Blood Glucose Response and Insulin

Conditions
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Healthy

Intervention / Treatment
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* Other: 1/4 cup- Small red lentil
* Other: 1/4 cup- Small green lentil
* Other: 1/4 cup- corn
* Other: 1/4 cup- macaroni
* Other: 1/4 cup- white potato
* Other: 1/4 cup- white rice
* Other: 1/2 cup- small red lentil
* Other: 1/2 cup- small green lentil
* Other: 1/2 cup- corn
* Other: 1/2 cup- macaroni
* Other: 1/2 cup- white potato
* Other: 1/2 cup- white rice


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria Healthy men and women Age 18-40 years Body mass index (BMI) 20-30 kg/m2 Exclusion Criteria: Tobacco use Pregnant or breastfeeding Fasting blood glucose ≥ 7.0 mmol/L Two hour blood glucose ≥ 11.1 mmol/L after consuming 75g glucose drink (Oral Glucose Tolerance Test beverage) Any major medical condition including a history of AIDS or hepatitis Medical or surgical event requiring hospitalization within 3 months of randomization Any medications except a stable dose (3 months) of oral contraceptives, blood pressure or statin medications Blood pressure >140/90 mm Hg Natural health products (NHPs) used for glycemic control Probiotic supplements Dietary fibre supplements Consumption of >4 servings of pulses per week Food allergy or non-food life threatening allergy Shift workers Alcohol consumption >14 drinks/week or >4 drinks/sitting Recent or intended significant weight loss or gain (>4 kg in previous 3 months) Elite athletes

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: 1/2 cup<br>1/2 cup serving size arm | Other: 1/2 cup- small red lentil<br> <br> Other: 1/2 cup- small green lentil<br> <br> Other: 1/2 cup- corn<br> <br> Other: 1/2 cup- macaroni<br> <br> Other: 1/2 cup- white potato<br> <br> Other: 1/2 cup- white rice<br> <br> |
| Other: 1/4 cup<br>1/4 cup serving size arm | Other: 1/4 cup- Small red lentil<br> <br> Other: 1/4 cup- Small green lentil<br> <br> Other: 1/4 cup- corn<br> <br> Other: 1/4 cup- macaroni<br> <br> Other: 1/4 cup- white potato<br> <br> Other: 1/4 cup- white rice<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postprandial Blood Glucose |  | 2 hours Postprandial | 
| Postprandial Blood Insulin |  | 2 hours postprandial | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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lentils, diabetes, glycemia, insulin, glucose