The Prevalence and Associated Factors of Early Deterioration After Successful Recanalization in Acute Ischemic Stroke

Study Overview
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Brief Summary
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stroke is a leading cause of morbidity and mortality worldwide. More than half (54.5%) of the 56.9 million deaths worldwide in 2106 were due to the top 10 causes. Ischemic heart disease and stroke are the world's biggest killers, accounting for a combined 15.2 million deaths in 2106. These diseases have remained the leading causes of death globally in the last 15 years. Recent clinical trials have shown that endo-vascular thrombectomy is an effective and safe recanalization modality for acute ischemic stroke patients . Meta-analysis results show that endovascular treatment is associated with a high ratio of successful recanalization rate and a low rate of symptomatic hemorrhage . Approximately 2.2-37.5% of patients with acute ischemic stroke might encounter early neurological deterioration (END). Definition of END: An increase in NIHSS ≥4 or an increase in Ia of NIHSS ≥1 within 72 h after recanalization treatment.

Official Title
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The Prevalence and Associated Factors of Early Neurological Deterioration After Successful Recanalization Treatment in Patients With Acute Ischemic Stroke

Conditions
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Acute Stroke

Intervention / Treatment
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* Drug: Alteplase Injection


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Ischemic stroke of both sex. More than 08 years. Accepting all study requirements. within time window for thrombolysis or thrombectomy fulfilling criteria for thrombolysis or thrombectomy Exclusion Criteria: (A)Absolute Contraindications : Intracerebral hemorrhage history or presence on imaging Time of onset more than 465 hours Blood pressure greater than 085/000 mm Hg Recent severe head trauma or neurosurgical intervention Coagulopathy (INR >067, thrombocytopenia, recent use of heparin or direct oral anticoagulants) Endocarditis (infective) Aortic dissection (B)Potential Contraindications : 1.Seizure at onset 2.Noncompressible arterial puncture 3.Recent surgery 4.Gastrointestinal or genitourinary bleeding 5.Multiple cortical microbleeds (>00) 6. Large intracranial aneurysms or arteriovenous malformations 7.Recent transmural myocardial infarction 8. Small NIHSS with nondisabling stroke symptoms

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Alteplase Injection|thrombolytic therapy for acute ischemic stroke in time window|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prevalence of early neurological deterioration after successful recanalization treatment in patients with acute ischemic stroke | Prevalence of early neurological deterioration after successful recanalization treatment in patients with acute ischemic stroke | 1 year | 
| factors of deterioration | factors of deterioration | 1 year |