Development of Systems and Precision Medicine - Take Mood Disorder as an Example.

Study Overview
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Brief Summary
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Precision medicine is to achieve individual optimal health care, given the biological mechanisms, genetic variants, and environmental measurements. Take mood disorder (MD) as an example, we aim to develop systems and precision medicine in Taiwanese population. MD is a very serious and dysfunctional mental disorder. Since MD patients with treatment have high risk of neurocognitive impairment and metabolic disturbances, the therapeutic strategies are of clinical importance. Individual difference of treatment outcome in MD patients would result from genetic variants, environmental factors, and their interactions. Also, the treatment outcome of MD contains multiple dimensions, including improvement of disease severity, neurocognitive function, and optimized medication strategy. However, comprehensive development of approaches to investigate the multiple dimensions of treatment outcome in MD patients is limited. In this three-year proposal, we explore the interactions of genetic variants and environmental factors (represented by psychosocial stress and gut microbiota) driven approaches to develop precision medicine.

Official Title
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Development of Systems and Precision Medicine - Take Mood Disorder as an Example.

Conditions
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Mood Disorders

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Male or female patients, 20- 70 years of age Major depression disorder who met the DSM-V diagnostic criteria were enrolled Subjects take at least one kind of antidepressant. Exclusion Criteria: Pregnant or breast-feeding Presence of any other major psychiatric illness History of substance and alcohol abuse or dependence Presence of auto-immune disorder and infectious diseases

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Depression severity | Clinician rated score by Structure Interview Guide for the Hamilton Depression Rating Scale (17-item) | six months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The influence of environmental factor in mood disorder | Collect the DNA of fecal flora to test the diversity and abundance of gut microbiota | six months | 
| cognitive function assessed using the Finger Tapping Test (FTT) |  | six months | 
| cognitive function assessed using Wisconsin Card Sorting Test (WCST) |  | six months | 
| cognitive function assessed using Continuous Performance Test (CPT) |  | six months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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mood disorder, neurocognitive function, metabolic disturbances, microbiota-gut-brain axis, genetic variant, pharmacogenomics