linjc16/ctgov huggingface dataset:
Longitudinal Study in Clinically Isolated Syndrome (CIS) Patients Treated With Interferon Beta

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to evaluate the role of cognitive disorders and quality of life in patients with CIS, considered as high risk to develop an MS, treated with interferon Beta. This prospective observational study will include 120 patients, all treated and evaluated annually with neurological extensive examination, ophthalmologic screening (OCT, OF, VEP, VF), auto questionnaire about fatigue (musicol, ELIF), quality of life (SEP-59), and conventional MRI.

Official Title
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Longitudinal Study in Clinical Isolated Syndrome Patients Treated With Interferon Beta. Correlation With Cognitive Disorders and Quality of Life.

Conditions
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Clinically Isolated Syndrome

Participation Criteria
=================
Eligibility Criteria
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Inclusion Criteria: Patients older than 18 years, Patients with CIS and temporo spatial dissemination for less than one year Patient without prior immunomodulatory treatment Patient informed of CIS diagnosis and MS according to McDonald criteria, Patients with EDSS inferior or egal to 5,5 Patients usually french-reader and with MMS >24 Patients informed of study protocol Patients agree to sign informed consent Patients with affiliation number from social French département. Exclusion Criteria: Secondary progressive MS Patient with acute relapse Patient already treated with IFN corticosteroids less than 15 days Patient with severe dépressive disorders Patient already included in clinical study Patient < 18 years Patient with known contra indications for beta interféron Every reason with can provoke an interruption of the study, regarding a patient empechment Contre indications for MRI or other tests required in the study pregnancy or lactation patient Under juridic protection

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical exams performed at Baseline and every year during 3 years Neurological examination: relapses recording and EDSS. Quality of life: SEP-59, MusiQOL. Neuropsychological screening |  | 3 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fatigue test: MS Fatigue, MRI (T1 gadolinium, T2, sagittale T1, acquisition volumique 3D T1), Optical coherence tomography (OCT) |  | 3 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
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MS, CIS, IFN, MRI, OCT, QOL
PECS and Parasternal Block for Breast Surgery

Study Overview
=================
Brief Summary
-----------------
Propose to evaluate efficacy of association between US guide parasternal block and pectorals nerves block (PECS) as anesthetic option for breast surgery (medial quadrantectomy and simple mastectomy). All patients undergoing medial quadrantectomy and simple mastectomy in 6 months period will be observed. All patients receive: US guide parasternal block at T4 and T6 space with 6ml of ropivacaine 0,75% and PECS type 2 block performed with 24ml of ropivacaine 0,75%. During surgery patients receive light sedation with continuous infusion of propofol Will be observed: Additional local anesthetic infiltration from surgeon. Pain at rest and during movement quantified as Numerical Rating Scores (0-10) during the first 12 hours postoperatively. Eventual side effects such as nausea/vomiting.

Official Title
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Observational Study to Evaluated Efficacy of Parasternal and PECS Blocks Association in Breast Surgery

Conditions
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Quadrantectomy, Mastectomy

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age> 18 years; ASA score I - II - III; undergoing elective medial quadrantectomy breast surgery; undergoing elective mastectomy not reconstruction breast surgery; signed informed consent; Exclusion Criteria: chronic therapy with opioids/ antidepressants; urgent/emergent surgery; postoperative transfer to the intensive care unit; known allergy to any drug medication; local skin infection; epilepsy; alcohol or drug abuse;

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Local Anesthetic infiltration | Quantify amount of local anesthetic infiltration from surgeon to get perfect anesthesia | intraoperatory period | 
| Convention in general anesthesia | Number of patients require general anestesia to proceed to surgery | preoperative period | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain | Rest and in mouvement pain as NRS scale | 12 hours postoperatively | 
| PONV | Postoperative nausea/vomiting incidence | 12 hours postoperatively |
Familial and Environmental Factors Behind Migraine

Study Overview
=================
Brief Summary
-----------------
Migraine is a chronic neurological disease characterized by recurrent moderate to severe headaches often in association with a number of autonomic nervous system symptoms. Migraines are believed to be due to a mixture of environmental and genetic factors. About two-thirds of cases run in families. Changing hormone levels may also play a role, as migraines affect slightly more boys than girls before puberty, but about two to three times more women than men after puberty. The risk of migraines usually decreases during pregnancy. The exact mechanisms of migraine are not known. It is, however, believed to be a neurovascular disorder. The primary theory is related to increased excitability of the cerebral cortex and abnormal control of pain neurons in the trigeminal nucleus of the brainstem.

Detailed Description
-----------------
Environmental influences play a role, but family studies suggest that defective genes may be primarily involved in disease causation. The mode of transmission of typical migraine in families is still unclear, but it is widely believed to be multifactorial although a role for a major susceptibility gene cannot be excluded. Aim of study: we aim to study the familial risk for developed migraine and its relation to EEG changes.

Official Title
-----------------
Familial and Environmental Factors Behind Migraine

Conditions
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Migraine

Intervention / Treatment
-----------------
* Diagnostic Test: International Headache Society Test


Participation Criteria
=================
Eligibility Criteria
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Inclusion Criteria: Fullfilled Migraine chriteria Exclusion Criteria: Genereal Neurologic Disease

Ages Eligible for Study
-----------------
Minimum Age: 15 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Migraine patients<br> | Diagnostic Test: International Headache Society Test<br>* Thorough History of Patients and families<br>* Other names: Family Pedigree Chart;|
| Control<br> | Diagnostic Test: International Headache Society Test<br>* Thorough History of Patients and families<br>* Other names: Family Pedigree Chart;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diagnosis of risk factors for migraine | Familial History | 6 months |
Coordinated Endoscopic Colorectal Cancer Screening

Study Overview
=================
Brief Summary
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The investigators aim to use a randomized design to test the effects of 1) tailored physician recommendations, relative to non-specific recommendations, and 2) coordinated physician office management systems on patient adherence to colorectal cancer screening recommendations.

Detailed Description
-----------------
The investigators aim to use a randomized design to test the effects of 1) tailored physician recommendations, relative to non-specific recommendations, and 2) coordinated physician office management systems on patient adherence to colorectal cancer screening recommendations. To accomplish these aims, the investigators propose 1) to use existing physician practice-based computerized patient registration systems to define populations of 50 to 79 year-old pri-mary care patients, 2) to use mailed questionnaires to determine colorectal cancer risk factor status and prior colorectal cancer screening history, 3) to use responses from mailed questionnaires to identify persons not adhering to colorectal cancer screening guidelines, 4) to use computer driven algorithms to help physicians prepare and deliver individually tailored and written colorectal cancer screening recommendations, and 5) to develop, implement, and evaluate a centralized service for delivering high quality screening flexible sigmoidoscopy.

Official Title
-----------------
Coordinated Endoscopic Colorectal Cancer Screening

Conditions
-----------------
Preventive Health Services

Intervention / Treatment
-----------------
* Behavioral: Help with physician office and patient management
* Behavioral: Tailored physician recommendation letter


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: - Exclusion Criteria: history of colorectal cancer or polyps flexible sigmoidoscopy within five years of enrollment barium enema within five years of enrollment colonoscopy within five years of enrollment

Ages Eligible for Study
-----------------
Minimum Age: 50 Years
Maximum Age: 79 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: Help with physician office and patient management|nan|
|Behavioral: Tailored physician recommendation letter|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Medical record verified flexible sigmoidoscopy or colonoscopy |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
colorectal cancer screening, sigmoidoscopy, colonoscopy
Use of Incretins in Diabetic Patients

Study Overview
=================
Brief Summary
-----------------
Observational, retrospective study, conducted in diabetic patients aimed to evaluate the effects on the glyco-metabolic control and on cardiovascular events of different DPP-4 inhibitors. Patients will be stratified in patients taking different DPP-4 in addition to sulfonylureas, biguanides, thiazolidinediones, insulin, compared to those in therapy with other hypoglycemic classes, such as sulphonylureas, biguanides, thiazolidinediones, insulin, alone or in combination, in primary and secondary prevention.

Official Title
-----------------
Observational Study on the Use of Incretins in Diabetic Patients: Evaluation of Metabolic Effects and Cardiovascular Events

Conditions
-----------------
Diabetes Mellitus, Type 2

Intervention / Treatment
-----------------
* Drug: DPP-4 inhibitors


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Type 2 diabetic patients On oral hypoglycemic agents ± basal insulin In primary and secondary prevention Exclusion Criteria: - Patients with a follow-up of less than 8 years

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| DPP-4 plus other therapies<br>Patients in therapy with DPP-4 inhibitors in addition to sulfonylureas and/or biguanides and/or thiazolidinediones and/or insulin | Drug: DPP-4 inhibitors<br>* Patients will be retrospectively evaluated after the addition of a DPP-4 inhibitor to previously taken anti-diabetic therapy<br>|
| Other therapies<br>Patients in therapy with other hypoglycemic classes, such as sulphonylureas and/or biguanides and/or thiazolidinediones and/or insulin. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Glycated hemoglobin | Percentage | 8 years | 
| Fasting plasma glucose | mg/dl | 8 years | 
| Post-prandial plasma glucose | mg/dl | 8 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Angina pectoris | Percentage | 8 years | 
| Extrasystoles | Percentage | 8 years | 
| Atrial fibrillation | Percentage | 8 years | 
| Fatal myocardial infarction | Percentage | 8 years | 
| Non-fatal myocardial infarction | Percentage | 8 years | 
| Heart failure | Percentage | 8 years | 
| Cardiovascular death | Percentage | 8 years |
Cost Effectiveness if Primary PCI Versus Thrombolytic Therapy in Acute STEMI in Assiut University Hospital

Study Overview
=================
Brief Summary
-----------------
Cost effectiveness between PPCI and thrombolytic therapy in STEMI patients without contraindications

Detailed Description
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Cost effectiveness between PPCI and thrombolytic therapy in STEMI patients 100 patient each within 90 m for PPCI and 6h for thrombolytic

Official Title
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Cost Effectiveness of Primary PCI Versus Thrombolytic Therapy in STEMI in Assiut University Hospital

Conditions
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ST Elevation Myocardial Infarction

Intervention / Treatment
-----------------
* Procedure: Primary PCI


Participation Criteria
=================
Eligibility Criteria
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Inclusion Criteria: All PPCI patients within 90 minutes door to ballon. All thrombolytic patient without contraindication ,within 6 golden hours of chest pain. Exclusion Criteria: patients don't meet inclusion criteria
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Primary PCI<br>In primary PCI we use arterial sheath , wires ,heparin ,intracoronary stents | Procedure: Primary PCI<br>* Primary percutaneous coronary intervention in acute myocardial infarction patients<br>|
| Thrombolytic<br>In patients recieving thrombolytics they continue on LWMH for 72h ,plus aspirin , clopedogril , BB, statins | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Compare between PPCI and thrombolytic therapy regarding over all cost in STEMI patients | we will compare different outcomes in ST elevation myocardial infarction patients presented to our hospital who had recieved intervention (primary PCI ) versus thrombolytic as regarded in all over cost in egyptian pounds and follow up for 6 month | one year for collecting 100 patient for each arm with follow up 6 month |
Transfer Accuracy of Indirectly Bonded Orthodontic Braces With Different Transfer Trays

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to comparatively investigate the performances of two different and widely used transfer trays during indirect bonding of the orthodontic braces.

Detailed Description
-----------------
The aim of the study is to compare the accuracy of orthodontic bracket and tube transfer between double layer silicone and double layer vacuum formed trays. The sample included 368 attachments bonded in 16 patients. Each patient received one silicone and one vacuum formed tray which were randomly allocated to provide 8 trays of each type for the upper and lower arches. 3D scan data and local best-fit alignments were used to calculate the translational and rotational movements of the orthodontic attachments. Chi-square and Mann-Whitney U tests were used to compare transfer accuracy and success between the groups.

Official Title
-----------------
Transfer Accuracy of Indirectly Bonded Orthodontic Attachments With Vacuum Formed and Silicone Transfer Trays

Conditions
-----------------
Malocclusion

Intervention / Treatment
-----------------
* Device: Indirect bonding


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: The presence of indication for both arches to be bonded in the same appointment Exclusion Criteria: Presence of restorations, hypoplasia or decalcification on vestibular tooth surfaces Abnormal crown morphology

Ages Eligible for Study
-----------------
Minimum Age: 15 Years
Maximum Age: 20 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: 1:1
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Silicone<br>Indirect bonding performed with the silicone trays | Device: Indirect bonding<br>* Indirect bonding is the technique where orthodontic appliances are first placed on a model of the patient and then transferred to the patient using some kinf of trays<br>|
| Active Comparator: Vacuum formed<br>Indirect bonding performed with the vacuum formed trays | Device: Indirect bonding<br>* Indirect bonding is the technique where orthodontic appliances are first placed on a model of the patient and then transferred to the patient using some kinf of trays<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Transfer accuracy (composite outcome) in milimetres and degrees. Which is measured on computer software. | The positional deviations between the attachments on the models and the mouth | Day 0 - Day 2 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Indirect bonding, Accuracy
Content Validation of Quality of Life and Symptom Questionnaires for Pheochromocytoma and Paraganglioma

Study Overview
=================
Brief Summary
-----------------
The purpose of this qualitative study is to evaluate the clarity and comprehensiveness of two disease-specific questionnaires, and to evaluate how effective these questionnaires are at assessing the quality of life and symptoms of patients with pheochromocytoma or paraganglioma.

Official Title
-----------------
Content Validation of the EORTC QLQ-C30 Version 3.0, and NIH Quality of Life and Symptoms Questionnaire for Pheochromocytoma and Paraganglioma

Conditions
-----------------
Pheochromocytoma, Paraganglioma

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Provide written informed consent and be willing to comply with protocol requirements Participant is aged ≥ 18 Have a documented (medical record) diagnosis of either pheochromocytoma or paraganglioma with active symptoms or within 60 days of curative therapy Exclusion Criteria: Patient is currently asymptomatic from pheochromocytoma/paraganglioma diagnosis or duration > 60 days from curative therapy Participant has a clinically significant disorder, including alcohol or drug abuse, which may interfere with study participation or which may affect the outcome of the study as judged by the investigator. Participant has a mental disability or significant mental illness, legal incapacity or limited legal capacity or any other lack of fitness, in the investigator's opinion, to preclude the subject's participation in or ability to complete the study. Participant is currently too unwell to take part in the study.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The main objective of this study is to evaluate content validity of the NIH Quality of Life and Symptoms Questionnaire for Pheochromocytoma and Paraganglioma and EORTC-QLQ-C30 in patients with pheochromocytoma or paraganglioma. |  | Single Visit | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
paraganglioma, pheochromocytoma