Prognosis Value of Pro-adrenomedullin in Acute Exacerbations of COPD in ER

Study Overview
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Brief Summary
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The purpose of this study is to determine whether pro-adrenomedullin (Mr proADM)in addition to clinical evaluation is effective to predict outcome of acute exacerbations of COPD patients visiting the emergency room(ER).

Detailed Description
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Acute exacerbation of COPD (AECOPD)are usual and frequent cause of admission in emergency room (ER). No validated clinical or biological predictor of evolution are available. The main objective is to determine the prognosis value of Mr proADM in addition to the clinical risk stratification for AE COPD patients in ER. Patients presenting with a AECOPD diagnosis in ER will have a blood sample collected and freezed at their admission. Mr proADM will be assessed at the end of the study. Clinicians in charge of patients will not have the result during the management of their patients. This study implies no change in the patients' management. Data related to the patients'demographic,current exacerbation and basic COPD characteristics will be collected.

Official Title
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Usefulness of Pro-adrenomedullin (MR proADM)as a Predictor of Outcome in Acute Exacerbations of COPD Visiting the Emergency Room

Conditions
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Pulmonary Disease, Chronic Obstructive Patients Admitted in Emergency Department for Acute Exacerbation

Intervention / Treatment
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* Other: AECOPD Mr proADM


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients > 40 years old Acute exacerbation of COPD Exclusion Criteria: Medico social conditions not allowing home discharge Other causes of Dyspnea: Pneumothorax, pulmonary embolism, pulmonary oedema, lung cancer Pneumonia on chest ray acute respiratory distress requiring immediate ICU transfer

Ages Eligible for Study
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Minimum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: AECOPD Mr proADM<br>Patients involved in this study will have a simple blood sample collected for Mr proADM assessment at the end of study | Other: AECOPD Mr proADM<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| composite outcome measure | Death, subsequently transfer to ICU, relapse, need to be ventilated after 24 hours of their admission in ER | at Day 30 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| composite outcome | Death, subsequently transfer to ICU, relapse, need to be ventilated after 24 hours of their admission in ER | at Day 7 of ER admission | 
| correlation between Mr proADM and patients Severity | Correlation between MR proADM and patient's severity | at Day 7 and Day 30 of ED admission | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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AECOPD Mr ProADM Biomarkers ER Outcome