A Study to Explore Treatment Regimens and Clinical Outcomes of the NSCLC Patients With Different Dirver Genes

Study Overview
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Brief Summary
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A single-center, non-interventional prospective observational study in the NSCLC patients with different driver genes

Detailed Description
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The trial was designed as a single-center non-interventional prospective observational study to explore clinical treatments of the NSCLC patients with different driver genes, the impact factors of patient survivals, and the relevance of gene types, clinical treatments, and distribution of gene types. The follow-up visits, interactions between the investigators and patients, patient questionnaires/quality of life, and other patient information will be uploaded via mobile APP, and webchat every three months.

Official Title
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A Prospective Observational Study to Explore Treatment Regimens and Clinical Outcomes of the NSCLC Patients With Different Driver Genes

Conditions
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Non-small Cell Lung Cancer

Intervention / Treatment
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* Other: Patients with driver genes


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: The patients with lung cancer who were performed with next-generation sequencing (NGS) technology from 2015 to 2017; The patients who were at least 18 years; The pathologically diagnosed patients with non-small cell lung cancer (NSCLC) Exclusion Criteria: -None

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| NSCLC patients with driver genes<br>NSCLC patients and driver genes | Other: Patients with driver genes<br>* Patients with driver genes<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Differences in overall survival rates | Differences in overall survival rates of the NSCLC patients with various gene types | 2018-2022 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Interaction impact between gene types and treatment modalities or regimens on disease-free survivals | Interaction impact between gene types and treatment modalities or regimens on disease-free survivals | 2018-2022 | 
| Statuses of clinical treatment regimens | Statuses of clinical treatment regimens of the NSCLC patients | 2018-2022 | 
| Relevance of gene types | Relevance of gene types and clinical characteristics of the NSCLC patients | 2018-2022 | 
| Relevance of overall survival rates and gene types | Relevance of overall survival rates and gene types of the NSCLC patients | 2018-2022 | 
| Impacts of disease-free survivals on gene types | Impacts of disease-free survivals on gene types of the NSCLC patients | 2018-2022 | 
| Impacts of progression-free survivals | Impacts of progression-free survivals on gene types of the NSCLC patients | 2018-2022 | 
| Impact factors of overall survivals | Impact factors of overall survivals of the NSCLC patients | 2018-2022 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Non-small cell lung cancer, gene mutations