Local Anesthesia in Molar Teeth With Molar Incisor Hypomineralization

Study Overview
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Brief Summary
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To compare responses to electrical pulp test (EPT) and cold test among molar incisor hypomineralization (MIH)-effected and not MIH-effected carious teeth before and after administration of local anesthesia for caries removal.

Detailed Description
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Fifty carious permanent first molar teeth (25 MIH-effected, 25 not MIH-effected) were included. Firstly, radiographic caries depth, International Caries Detection and Assessment System (ICDAS) codes and MIH levels of teeth were recorded. Then, during the treatment, EPT and cold test were performed before and after the administration of local anesthesia. Visual Analog Scale for Pain was used to evaluate cold test and pain during treatment. When interpreting results, significancy level was stated for the values of p<0.05.

Official Title
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Effectiveness Of Local Anesthesia In Molar Teeth With Molar Incisor Hypomineralization-A Prospective Study

Conditions
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Molar Incisor Hypomineralization

Intervention / Treatment
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* Diagnostic Test: Evaluation of cold test
* Diagnostic Test: Evaluation of electrical pulp test
* Diagnostic Test: Evaluation of pain during the treatment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy participants Exclusion Criteria: Not being cooperative during treatment procedure

Ages Eligible for Study
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Minimum Age: 6 Years
Maximum Age: 12 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: MIH-effected carious first permanent molar teeth<br>MIH-effected carious permanent first molar teeth were well-demarcated white/yellow or brown/yellow enamel opacities which is a sign for hypomineralization and asymptomatic which meant to be without any spontaneous pain or pain during eating or drinking, percussion or palpation tenderness, formation of abcess or fistula. | Diagnostic Test: Evaluation of cold test<br>* Cold test evaluation to describe the sensitivity level of teeth due to induce the hydrodynamic forces in dentine tubules.<br>Diagnostic Test: Evaluation of electrical pulp test<br>* Electrical pulp test evaluation to describe the sensitivity level of teeth due to induce the nerve fibers in pulp tissue.<br>Diagnostic Test: Evaluation of pain during the treatment<br>* Describe the sensitivity level due to induce the hydrodynamic forces during treatment procedure.<br>|
| Active Comparator: not MIH-effected carious first permanent molar teeth<br>The carious not MIH-effected teeth were only carious without any hypomineralize areas and asymptomatic which meant to be without any spontaneous pain or pain during eating or drinking, percussion or palpation tenderness, formation of abcess or fistula. | Diagnostic Test: Evaluation of cold test<br>* Cold test evaluation to describe the sensitivity level of teeth due to induce the hydrodynamic forces in dentine tubules.<br>Diagnostic Test: Evaluation of electrical pulp test<br>* Electrical pulp test evaluation to describe the sensitivity level of teeth due to induce the nerve fibers in pulp tissue.<br>Diagnostic Test: Evaluation of pain during the treatment<br>* Describe the sensitivity level due to induce the hydrodynamic forces during treatment procedure.<br>|
| Placebo Comparator: MIH-effected non-carious first permanent molar teeth<br>MIH-effected teeth were carious permanent first molar teeth with well-demarcated white/yellow or brown/yellow enamel opacities which is a sign for hypomineralization and did not have any sign of caries. | Diagnostic Test: Evaluation of cold test<br>* Cold test evaluation to describe the sensitivity level of teeth due to induce the hydrodynamic forces in dentine tubules.<br>Diagnostic Test: Evaluation of electrical pulp test<br>* Electrical pulp test evaluation to describe the sensitivity level of teeth due to induce the nerve fibers in pulp tissue.<br>Diagnostic Test: Evaluation of pain during the treatment<br>* Describe the sensitivity level due to induce the hydrodynamic forces during treatment procedure.<br>|
| Placebo Comparator: not MIH-effected non-carious first permanent molar teeth<br>not any signs of being caries or hypomineralization. | Diagnostic Test: Evaluation of cold test<br>* Cold test evaluation to describe the sensitivity level of teeth due to induce the hydrodynamic forces in dentine tubules.<br>Diagnostic Test: Evaluation of electrical pulp test<br>* Electrical pulp test evaluation to describe the sensitivity level of teeth due to induce the nerve fibers in pulp tissue.<br>Diagnostic Test: Evaluation of pain during the treatment<br>* Describe the sensitivity level due to induce the hydrodynamic forces during treatment procedure.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cold test results | Visual Analog Scale for Pain was used to evaluate the cold tests for before and after the local anesthesia. Visual analog scale was used to rate the sensitivity level of patients with 6 different faces representing different levels of pain from 0=no pain to 10=unbearable pain. | Time frame of cold test evaluation was aproximately 1 hour for each participant. | 
| Electrical pulp test results | Electrical pulp test values at which patients felt sensitive were recorded. | Time frame of electrical pulp test evaluation was aproximately 1 hour for each participant. | 
| Pain during the treatment | Visual Analog Scale for Pain was used to evaluate the pain during the treatment. Visual analog scale was used to rate the sensitivity level of patients with 6 different faces representing different levels of pain from 0=no pain to 10=unbearable pain. | Pain during the treatment was evaluated for aproximately 1 hour for each participant. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Anesthesia, Cold test, Electrical pulp test