Motivation and Methylphenidate

Study Overview
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Brief Summary
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The purpose of this study is to evaluate the impact of methylphenidate, a mixed dopaminergic and noradrenergic agent, onto the different components of motivation: decision-making, effort allocation and instrumental learning.

Official Title
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Etude Comparative Monocentrique, randomisée, en Cross-over, en Double Aveugle, Contre Placebo, de l'Action du méthylphénidate Sur Les paramètres Cognitifs de la Motivation

Conditions
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Motivation, Apathy, Impulsive Behavior

Intervention / Treatment
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* Drug: Ritalin 10Mg Tablet


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: weight>= 50kg and <=90kg free and informed consent social security affiliation no chronic illness no previous participation to a protocol wth similar tasks no special legal status (guardianship,trusteeship) no personnal or familial neurologic or psychiatric background no contraceptive device for a reproductive woman Exclusion Criteria: inability to squeeze a handgrip smoking psychoactive substance consumption less than 3 weeks ago pregnant or breastfeeding woman hypersensitivity to methylphenidate hyperthyroidism cardiovascular or cerebrovascular disease respiratory, hepatic or renal failure glaucoma pheochromocytoma gluten intolerance or hypersensitivity galactosemia, glucose malabsorption syndrome, lactase deficit countraindicated meds (IMAO, IMAO-A, orhtosympathomimetics, alcaloids, linezolin, enzymatic inducers, psycho-active drugs)

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: methylphenidate<br> | Drug: Ritalin 10Mg Tablet<br>* ingestion of an oral single-dose<br>|
| Placebo Comparator: inactive pill<br> | Drug: Ritalin 10Mg Tablet<br>* ingestion of an oral single-dose<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| coefficient of sensitivity to reward | Parameter characterizing the influence of reward expectation/experience onto behavior for each individual. This parameter is estimated through the fit of computational models to behaviors recorded in a battery of motivational tasks (choice task, effort task, Learning task). | two hours after administration | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| coefficient of sensitivity to effort | Parameter characterizing the influence of effort expectation/experience onto behavior for each individual. This parameter is estimated through the fit of computational models to behaviors recorded in a battery of motivational tasks (choice task, effort task, Learning task). | two hours after administration | 
| coefficient of sensitivity to punishment | Parameter characterizing the influence of punishment expectation/experience onto behavior for each individual. This parameter is estimated through the fit of computational models to behaviors recorded in a battery of motivational tasks (choice task, effort task, Learning task). | two hours after administration | 
| coefficient of sensitivity to delay | Parameter characterizing the influence of delay expectation onto behavior for each individual. This parameter is estimated through the fit of computational models to behaviors recorded in a battery of motivational tasks (choice task, effort task, Learning task). | two hours after administration |