linjc16/ctgov huggingface dataset:
Micronutrients in Children in Critical Care With Cardiac Conditions

Study Overview
=================
Brief Summary
-----------------
This study aims to explore the frequency and types of micronutrient deficiencies in a sample of UK children with CHD using standard and novel markers in blood. The study will also explore whether micronutrient deficiencies increase the risk of complications after heart surgery. This study will identify any nutrient deficiencies that need monitoring in clinical practice.

Detailed Description
-----------------
Congenital heart disease (CHD) is one of the most common birth defects in the UK. Children with CHD are at risk of underfeeding and undernutrition. This is due to both the increased nutritional requirements of the disease and sometimes clinical management, which often hinders delivery of optimal nutrition.There are as yet no studies assessing micronutrient body stores in children with CHD or whether micronutrient deficiencies predict poor clinical outcomes, such as post-operative complications, after major cardiac operations. This study aims to explore the frequency, types and associations of micronutrient deficiencies in children with CHD using standard and novel markers in blood. The study will also explore whether micronutrient deficiencies increase the risk of complications after heart surgery. This study will identify any nutrient deficiencies that need monitoring in clinical practice.

Official Title
-----------------
Micronutrient Deficiencies in Children and Infants With Congenital Heart Diseases (CHD) Admitted for Cardiac Surgery: A Proof-of-concept Study

Conditions
-----------------
Heart Defects, Congenital

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Infant or child admitted for elective congenital cardiac surgery at the Royal Hospital for Sick Children, Glasgow. Aged less than 5 years old Exclusion Criteria: Infant or child admitted for emergency cardiac surgery Infant or child whose carer with parental responsibility is unable to communicate in English

Ages Eligible for Study
-----------------
Maximum Age: 5 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Micronutrient Status | Micronutrient concentrations in plasma and erythrocytes | Pre- and post- operative: 24-48 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative LOS | Length of hospital stay | 1 year | 
| Postoperative Infectious complications | Incidence of infections | 1 year | 
| Postoperative ventilator time | Duration of ventilation | 1 year | 
| Postoperative LICU | Length of stay in PICU | 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Micronutrients, Paediatric, Critical care
Intracoronary Adenosine Administration to Prevent Periprocedural Myonecrosis in Elective Coronary Angioplasty

Study Overview
=================
Brief Summary
-----------------
Aim of the study is to evaluate the benefits from adjunctive intracoronary administration of adenosin in elective patients undergoing coronary angioplasty.

Detailed Description
-----------------
This study will investigate the effects of adjunctive intracoronary administration of adenosine on periprocedural myocardial infarction as compared to placebo. This is a double-blind randomized trial single-center study. The enrollment will last 10 months.

Official Title
-----------------
Prevention of Cardiac and Vascular Periprocedural Complications in Patients Undergoing Coronary Angiography or Angioplasty: Intracoronary Adenosine Administration to Prevent Periprocedural Myonecrosis in Elective Coronary Angioplasty. A Prospective Double-blind Randomized Trial.

Conditions
-----------------
Coronary Angioplasty

Intervention / Treatment
-----------------
* Drug: Adenosine
* Drug: Placebo


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients undergoing elective coronary angioplasty Exclusion Criteria: Marked Bradycardia (< 40 bpm) Previous allergy to adenosine Inability to sign the informed consent Asthma Elevated cardiac enzymes (troponin I o CK-MB)
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Placebo<br>Intracoronary Placebo administration | Drug: Placebo<br>* Intracoronary Placebo administration<br>|
| Active Comparator: Adenosine<br>Intracoronary adenosine administration | Drug: Adenosine<br>* Intracoronary adenosine administration (180 ug for LCA and 120 ug for RCA)<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Increase in troponin I (> 3 times the upper normal limit) |  | At 12 hours after the procedure | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| MACE(death, MI, urgent target-vessel revascularization) |  | 72 hours | 
| Angiographic Coronary flow, as evaluated by corrected TIMI frame count. |  | 1 minute after the final stent implantation | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Adenosine, randomized trial, periprocedural myocardial necrosis, elective coronary angioplasty
The Impact of the Biologist Performing the Embryo Transfer on the Cycle Outcome

Study Overview
=================
Brief Summary
-----------------
This is a retrospective single center analysis which includes all the fresh, IOC (insemination of in vitro matured oocytes) and frozen embryo transfer (ET) performed between January 2000 and December 2019 at Humanitas Fertility Center after IVF-ICSI (In Vitro Fertilization - Intracytoplasmic Sperm Injection) cycles. The primary objective is to determine the impact of the biologist performing the embryo transfer on the pregnancy probability, in terms of ongoing pregnancy rate (OPR), defined as the number of viable pregnancies that had completed at least 12 weeks of gestation on the total number of ET performed. Secondary end point is to evaluate whether the biologists improve their performances as their experience increases, allowing the drawing of an ET learning curve in term of pregnancies for the different biologists. The biologist's experience was assessed in terms of number of previous interventions performed prior to the day of ET. A total of 28 operators were eligible to participate in the study. Any biologists who performed less than 100 ETs was excluded from the analysis.

Official Title
-----------------
Different Actors for the Same Play: the Impact of the Biologist Performing the Embryo Transfer on the Cycle Outcome

Conditions
-----------------
Infertility

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: Exclusion Criteria: Any biologist who performed less than 100 embryo transfers was excluded from the analysis.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 43 Years

Sexes Eligible for Study
-----------------
Female

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ongoing pregnancy rate | The number of viable pregnancies that had completed at least 12 weeks of gestation per total ETs | 20 years |
Duodenostomy to Treat Duodenal Perforation

Study Overview
=================
Brief Summary
-----------------
In this study the investigators focused on duodenal perforations, requiring a tube duodenostomy and have analyzed the main features, that have influenced the surgical choices. Five patients were enrolled. Most of duodenal perforations can successfully be managed by simple repair, while complicated procedures are needed for complex injuries. Tube duodenostomy is a damage control procedure, for large duodenal perforations when further repair techniques are not recommended due to the duodenal damage, hemodynamic instability of the patient or the absence of surgical expertise for complex reconstruction.

Official Title
-----------------
Duodenostomy on Foley and Gastroenteroanastomosis: Treatment of Second Duodenal Part Perforation.

Conditions
-----------------
The Focus of Study is to Elucidate Which Are the Factors Requiring the Duodenostomy and Which Postoperative Course is for These Patients

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: excessive size of perforation extreme presence of intra-abdominal infections. Exclusion Criteria: patients treated by medical therapy, endoscopic techniques, o surgical approaches

Ages Eligible for Study
-----------------
Maximum Age: 89 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Death of patient |  | 4 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Duodenostomy, duodenal perforation, emergency surgery
Decrease of Libido of Post-Operative Male-Female Transsexuals and a Healthy Female Control Group

Study Overview
=================
Brief Summary
-----------------
Participants fill out a questionnaire on libido and their possible partner relationship. A blood sample is taken for sex steroid analysis.

Detailed Description
-----------------
Participants fill out a questionnaire on libido and their possible partner relationship on the website http://www.onderzoek-libido.be. A blood sample is taken for sex steroid analysis. The relation will be investigated between testosterone, free testosterone, sex hormone binding globulin, estradiol, DHEA and androstenedione and scores on relational and sexual satisfaction and sexual desire.

Official Title
-----------------
Decrease of Libido of Post-Operative Male-Female Transsexuals and a Healthy Female Control Group

Conditions
-----------------
Transsexualism

Intervention / Treatment
-----------------
* Procedure: Filling out a questionnaire on libido and possible partner relationship
* Procedure: Sex steroid analysis


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Transsexual women with completed adaptation of the sex (all surgical procedures and hormonal treatments) The female control group must be 18-45 years

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Filling out a questionnaire on libido and possible partner relationship|nan|
|Procedure: Sex steroid analysis|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
The Effect of Vodcasting on Listening Comprehension

Study Overview
=================
Brief Summary
-----------------
Improvement of the internet and its tremendous growth has caused significant progress in transformation of information. Nowadays in any place of the world and in any time of the day by accessing through internet every student can use different kinds of information in World Wide Web which let him to make the best decision what, how and when to study. One of these educational technologies which are beneficial to learners is vodcast or video recording which are accessible through the internet.This paper is going to examine the listening comprehension in EFL learners and whether it may be improved by using vodcasts. So106 language learners of four different classes of Iranian higher intermediate in an English institute were chosen for this study. These learners were pre-tested by IELTS Listening Comprehension. Two classes were chosen as subject group which consisted of 54 learners. The remaining two classes were chosen as control group which consisted of 52 learners. Both groups were taught Listening Impact book, but students in subject group were provided some vodcasts based on the topic of their lessons. After 12 weeks of teaching both groups were post-tested.listening comprehension will be compared using independent t-test and paired t-test.

Conditions
-----------------
Listen to Vodcast

Intervention / Treatment
-----------------
* Other: vodcasting
* Other: no intervension


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: EFL learner upper intermediate level Exclusion Criteria: Other levels

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 21 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: vodcasting<br>students who listen to downloaded vodcasting | Other: vodcasting<br>* listening to downloaded vodcasting files<br>|
| No Intervention: control<br>listen to the student book listening file | Other: no intervension<br>* Listen to student book listening files<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| improving listening comprehension | The outcome mesures will be completed up to 12 weeks using IELTS listening comprehension tests | up to 12 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
vodcasting,listening,language education
Comorbidity After Gastric Bypass

Study Overview
=================
Brief Summary
-----------------
To evaluate effect on comorbid disease and weight loss in the long-term (>five years) after Roux-en-Y gastric bypass (RYGB) surgery for severe obesity.

Detailed Description
-----------------
Individuals with severe obesity frequently have comorbid diseases, e.g. diabetes, hypertension, hyperlipidemia, and sleep apnea. We will study the remission rate and weight loss in the long-term (10 years) after Roux-en-Y gastric bypass (RYGB) surgery in a nationwide large group of patients.

Official Title
-----------------
Long-term Resolution of Comorbidites After Gastric Bypass

Conditions
-----------------
Severe Obesity

Intervention / Treatment
-----------------
* Procedure: Gastric bypass


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Registered individuals in Scandinavian Obesity Surgery Registry (SOReg) having had gastric bypass Exclusion Criteria: All other operations
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Gastric bypass<br>Patients undergoing gastric bypass | Procedure: Gastric bypass<br>* Gastric bypass surgery, i.e., small gastric pouch and excluded main stomach<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in comorbid conditions, as defined by use of pharmacological treatment | Remission of diabetes mellitus, hypertension, dyslipidemia, and depression as defined by use of pharmacological treatment, and sleep apnea as defined by use of CPAP. Data will be collected from SOReg. | 10 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patients with pathological laboratory data (corresponding to the studied comorbid conditions) | Glucose, HbA1c, LDL, HDL, triglycerides, and blood pressure | 10 years | 
| Weight loss | Peroperative weight (in kg) minus current weight (in kg) | 10 years | 
| BMI loss | Peroperative BMI minus current BMI. Weight and height will be combined to report BMI in kg/m^2. | 10 years |
An Open Label Trial to Assess the Safety and Efficacy of Oral R115866 in the Treatment Facial Acne

Study Overview
=================
Brief Summary
-----------------
This study is looking at a new oral drug to treat acne. All patients in the study will get active drug, there is no placebo arm.

Official Title
-----------------
An Open Label Pilot Trial to Assess the Safety and Efficacy of Oral R115866 in the Treatment of Moderate to Severe Facial Acne

Conditions
-----------------
Acne

Intervention / Treatment
-----------------
* Drug: Talarozole


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Male subject Presence of moderate to severe facial acne vulgaris: having a minimum of 15 papules and/or pustules and at least 2 nodulocystic lesions In good general health and free of any disease state or physical condition which, in the investigator's opinion, might have impaired evaluation of acne or exposed the subject to an unacceptable risk by trial participation Exclusion Criteria: Subjects with types of acne other than acne vulgaris Significant coexisting hepatic, renal, or bone marrow disease, hyperlipidemia, chronic pancreatitis, osteoporosis, or a history indicating adrenal cortex dysfunction or any other serious disease (including cancer and subjects known to be HIV positive) History of any malignancy in the past 5 years, except for adequately treated basal cell carcinoma of the skin History of heart failure, myocardial infarction within the past six months, cardiac arrhythmia, or under treatment for heart disorders Clinically significant abnormal ECG-intervals or morphology of the ECG; QT or QTc >470 ms in females or >450 ms in males Use of vitamin A (>1000 microgram/day), phenytoin, carbamazepine, warfarin, rifampicin, tetracyclines, ketoconazole, itraconazole, astemizole, terfenadine, cisapride, anti-psychotics, anti-depressants, lithium, antimalarials, alpha-blocking drugs, angiotensin-converting enzyme inhibitors, cyclosporin A, glucocorticosteroids and non-steroid anti-inflammatory drugs, non-potassium-sparing diuretics Use of oral retinoids 6 months prior to Visit 1 Use of other oral/topical therapy for acne unless stopped at Visit 1 Use of ultraviolet light (including artificial UVA and UVB as well as excessive natural sun exposure) unless stopped at Visit 1

Ages Eligible for Study
-----------------
Minimum Age: 16 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: A<br>Talarozole | Drug: Talarozole<br>* Oral Dose 1.0 mg once daily<br>* Other names: R115866;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Facial Lesion Count |  | Post 12 weeks treatment |
User Charges for General Practitioner Services in Denmark

Study Overview
=================
Brief Summary
-----------------
Currently, office visits at general practitioners is free of charge for patients. However, public commissions and the Danish Economic Council have suggested to implement user charges for services that currently is free of charge. The aim of this study is to examine the consequences of introducing user charges for general practitioner services. Data for the project will be collected from patients who have an appointment with a general practitioner. Patients will be asked whether they are willing to pay a specified amount for the consultation that they have scheduled. After the consultation, the GP register diagnoses.

Official Title
-----------------
Brugerbetaling i Almen Praksis (In Danish: User Charges for General Practitioner Services)

Conditions
-----------------
Consequences of User Charges

Intervention / Treatment
-----------------
* Behavioral: Willingness to pay


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with an appointment for a visit in a general practitioner clinic Reads and understand Danish Exclusion Criteria: -
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients<br> | Behavioral: Willingness to pay<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Willingness to pay | Whether a patient accept a specified amount for a GP consultation | once | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diagnoses | Diagnoses according to the Danish version of the International Classification of Primary Care (ICPC9 | Once |