Pressure Controlled Ventilation Versus Volume Controlled Ventilation in Upper Abdominal Surgery

Study Overview
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Brief Summary
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Comparison of mechanical powers produced at volume controlled and pressure controlled mechanical ventilation

Detailed Description
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The mechanical power created by mechanical ventilation, as a new concept, can enable to evaluate the effect of different components in the lung.Our aim in this study is to calculate mechanical power in different ventilation modes ( pressure controlled and volume controlled ventilation) and to compare them. To calculate the mechanical powers we will use Van der Meijden's mechanical power formula for pressure controlled ventilation and for volume controlled ventilation we will use Gattinoni's mechanical power formula. In the literature we haven't seen any publication comparing the mechanical power of two commonly used ventilation modes (volume controlled and pressure controlled ventilation)

Official Title
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Comparison of Pressure and Volume Controlled Ventilation in Terms of Mechanical Power in Upper Abdominal Surgery

Conditions
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Ventilator Lung

Intervention / Treatment
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* Other: Starting with volume controlled ventilation and changing the ventilation mode every 20 minutes
* Other: Starting with pressure controlled ventilation and changing the ventilation mode every 20 minutes


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ASA1-2 , >18 years old patients having upper abdominal surgery Exclusion Criteria: chronic obstructive lung disease, interstitial lung disease chronic renal failure Child-Pugh > 6 liver disease Patients who don't give consent NYHA > 2 heart failure

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Group 1<br>group 1 starts with volume controlled ventilation | Other: Starting with volume controlled ventilation and changing the ventilation mode every 20 minutes<br>* group 1 starts with volume controlled ventilation and we take three consecutive measurements in twenty minutes , after twenty minutes we change the ventilation mode to pressure controlled ventilation after letting washout we take three consecutive measurements at pressure controlled ventilation and we will repeat this protocol during surgery<br>|
| Other: Group 2<br>group 2 starts with pressure controlled ventilation | Other: Starting with pressure controlled ventilation and changing the ventilation mode every 20 minutes<br>* group 2 starts with pressure controlled ventilation and we take three consecutive measurements in twenty minutes , after twenty minutes we change the ventilation mode to volume controlled ventilation after letting washout we take three consecutive measurements at volume controlled ventilation and we will repeat this protocol during surgery<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| calculation of mechanical power changes in two different ventilation modes | mechanical power will be calculated using the Van der Meijden's formula for pressure support ventilation and Gattinoni's formula for volume controlled ventilation and two mechanical powers will be compared | change from at the beginning of surgery till the end of surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| postoperative pulmonary complications | postoperative pulmonary complication including pneumonia, acute lung injury, respiratory failure requiring reintubation | post-operative 7 days | 
| hospitalisation time | up to 20 days | up to 20 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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mechanical power, volume controlled ventilation, pressure controlled ventilation