linjc16/ctgov huggingface dataset:
Contralateral Strength-training After Anterior Cruciate Ligament (ACL) Reconstruction

Study Overview
=================
Brief Summary
-----------------
The main aims of the study are (1) to examine the impact of contralateral strength training on the quadriceps muscle function after ACL surgery and (2) to compare the magnitude of cross-education induced by NMES versus eccentric strength training.

Official Title
-----------------
Could Contralateral Quadriceps Strength Training Attenuate the Strength Loss in the ACL-operated Knee?

Conditions
-----------------
Muscle Weakness After Anterior Cruciate Ligament Reconstruction

Intervention / Treatment
-----------------
* Behavioral: Neuromuscular electrical stimulation
* Behavioral: eccentric training


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients scheduled for ACL reconstruction surgery Exclusion Criteria: Concomitant lower limb injury or disorder previous lower extremity open surgery on the contralateral lower limb cardiac disease pregnancy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: NMES<br>neuromuscular electrical stimulation (NMES) of the quadriceps muscle with Kneehab | Behavioral: Neuromuscular electrical stimulation<br> <br> |
| Experimental: eccentric training<br>unilateral eccentric resistance exercises | Behavioral: eccentric training<br> <br> |
| Sham Comparator: sham NMES<br>neuromuscular electrical stimulation of the quadriceps muscle with intensity which causes no visible contraction or displacement of the leg (activation below motor threshold) | Behavioral: Neuromuscular electrical stimulation<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in bilateral quadriceps muscle strength [Nm] |  | 1-2weeks preoperative/ 2weeks/ 8weeks/ 6month | 
| Change in quadriceps muscle activation |  | 1-2 weeks preoperative/ 2weeks/ 8weeks/ 6month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in muscle architecture |  | 1-2 weeks preoperative/ 2weeks/ 8weeks/ 6month | 
| Change in self-reported questionnaire outcomes (KOOS, WOMAClk) |  | 1-2weeks preoperative/ 2weeks/ 8weeks/ 6 month | 
| functional test outcomes | Assessment of present functional status by means of hop tests | 6month postop |
The Effects of Oxytocin on Patients With Borderline Personality Disorder

Study Overview
=================
Brief Summary
-----------------
RCT. Two substudies (clinical and experimental). Main objective of the trial is to examine if oxytocin, compared to placebo shows any additional effect on the therapy achievements (outcome) of patients with borderline personality disorder, who receive an in-patient standard psychotherapy (Dialectical-behavioral-therapy, Marsha Linehan (2006)). Secondary objectives : Investigate if oxytocin compared to placebo enhances social trust and emotion recognition in patients with borderline personality disorder. Comparison of the effects of Oxytocin on patients with BPD and major depression.

Official Title
-----------------
The Effects of Oxytocin on Patients With Borderline Personality Disorder

Conditions
-----------------
Effects of Oxytocin on Borderline Personality Disorder, Borderline Personality Disorder

Intervention / Treatment
-----------------
* Drug: Oxytocin
* Other: placebo


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Gender: Both, male and female Minimum Age: 18 Years Maximum Age: 50 Years Borderline personality disorder or major depression (clinical control group) Mini Mental Status Test > 27 (capacity to consent) Exclusion Criteria: chronic or acute somatic health problems Schizophrenia Bipolar affective disorder pregnancy breast feeding neurological disorder allergy to antidegradants

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Oxytocin<br>Oxytocin | Drug: Oxytocin<br>* Oxytocin<br>|
| Placebo Comparator: Placebo<br>Placebo | Other: placebo<br>* placebo<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| BPD Symptoms |  | BPD Symptoms | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Oxytocin, BPD, Borderline
Clinical and Radiological Evaluation of Two Mastoid Filling Products

Study Overview
=================
Brief Summary
-----------------
to compare, the osseous density in the mastoid of two products used to obliterate the mastoid during surgery for cholesteatoma

Detailed Description
-----------------
Primary objective: To compare the radiological aspect in the petrous bone of two obliteration products in adults, one year after surgery (Bioactive Glass S53P4 and biological Hydroxy apatite) secondary objective : To evaluate the cutaneous and the inner ear tolerance of bioactive glass S53P4 and biological hydroxy apatite when used in the mastoid and epitympanic obliteration for chronic otitis surgery

Official Title
-----------------
Clinical and Radiological Evaluation of Two Mastoid Filling Products in Patients With Cholesteratoma.

Conditions
-----------------
Prospective Study

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adult with cholesteatoma surgery Accepting the protocol and the radiological follow-up Exclusion Criteria: patient less than 18 years old

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hounsfield Unit | The attenuation and osseointegration of the BG granules: The quantitative analysis included bone attenuation measurements (in Hounsfield units, HU) in the circular region of interest (34mm2) of BGand of surrounding cortical bone and otic capsule using the otic capsule adjacent to the LSCC and the posterior fossa dural plate (DP) | one year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| decibel | Auditory level pre and postoperative evaluation clinical | one year | 
| decibel | audiological evaluation | one year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
osteoingration, surgery, cholesteatome
Systematic Review And Meta-Analysis Of Psoriasis Treatments.

Study Overview
=================
Brief Summary
-----------------
This project involved a systematic literature review of published trials of treatments for moderate-to-severe plaque psoriasis. Data was extracted from the publications on various psoriasis endpoints including the Physician Global Assessment (PGA), Dermatology Life Quality Index (DLQI), and Short-Form 36 (SF-36). A traditional meta-analysis and a mixed treatment comparison was conducted on the extracted data.

Detailed Description
-----------------
This project involved a systematic literature review of published trials of treatments for moderate-to-severe plaque psoriasis. Data was extracted from the publications on various psoriasis endpoints including the Physician Global Assessment (PGA), Dermatology Life Quality Index (DLQI), and Short-Form 36 (SF-36). A traditional meta-analysis and a mixed treatment comparison was conducted on the extracted data. We included all published randomized controlled trials of treatments for moderate-to-severe psoriasis that met the study inclusion criteria.

Official Title
-----------------
Biologic And Non-biologic Systemic Treatments For Moderate To Severe Plaque Psoriasis: A Systematic Review & Meta-Analysis

Conditions
-----------------
Psoriasis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Randomized controlled clinical trials of treatments for moderate-to-severe plaque psoriasis. Trials had to evaluate at least one of the following: Physician's Global Assessment (PGA), Dermatology Life Quality Index (DLQI) and/or the Short-Form 36 (SF-36). Exclusion Criteria: Observational studies Trials that did not report the Physician's Global Assessment (PGA), Dermatology Life Quality Index (DLQI) or the Short-Form 36 (SF-36).

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Psoriasis<br>Published data on moderate-to-severe plaque psoriasis. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Physician Global Assessment (PGA) |  |  | 
| Dermatology Life Quality Index (DLQI) |  |  | 
| Short-Form 36 (SF-36) |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| No secondary outcomes |  | No secondary outcomes | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
psoriasis, systematic review, meta-analyses
Cognitive Function and Body Mass Index in Children and Adolescents

Study Overview
=================
Brief Summary
-----------------
The child will complete computerized tasks and paper-pencil test, and will be presented with symbols, letters, or numbers on a computer screen and asked to respond by pressing a button on the computer. Before each task a researcher will explain the instructions of the task and assess if the child needs a break before completing the next task. While the child is completing computerized tasks, the parent/guardian will be asked to fill out paper-pencil questionnaires about the child and to sign a release of medical information form so that we can study how physical markers of health effect cognition.

Official Title
-----------------
Cognitive Function and Body Mass Index in Children and Adolescents

Conditions
-----------------
Obesity, Childhood, Obesity, Adolescent, Cognitive Orientation

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Local population (based on ethnicity) Healthy or overweight/obese Exclusion Criteria: History of developmental delay or disorders History of any medical conditions ( that may impact the development)

Ages Eligible for Study
-----------------
Minimum Age: 7 Years
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Healthy participants<br>BMI 5th percentile to less than the 85th percentile | |
| Overweight/Obese participants<br>BMI 85th percentile or more | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Perceptual organization index- Matrix reasoning subtest | The examinee views an incomplete matrix or series and selects the response option that completes the matrix or series. Scoring is based on whether the response is right or wrong. | 10-15 minutes | 
| Perceptual organization index- Block design subtest | The Block Design subtest is designed to measure the ability to analyze and synthesize abstract visual stimuli. While viewing a constructed model or a picture in the Stimulus Book, the examinee uses red- and-white blocks to re-create the design within a specified time limit. Scoring is based on how quickly the participant completes. | 15-20 minutes | 
| Processing speed index- Coding subtest | The processing speed index measures a child's ability efficiently to scan and understand visual information and complete a task with the data. Scoring is based on how many can the participant finish in 120 seconds. | 2-3 minutes | 
| Working memory index- Digit span subtest | The task digit span uses numbers. Memory span is a common measure of short-term memory. It is also a component of cognitive ability. Scoring is based on how many correct answers (recall) are achieved | 5-10 minutes |
Flupenthixol Treatment in Schizophrenic Cocaine Abusers - 1

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate the safety and efficacy of flupenthixol for cocaine dependence in individuals with schizophrenia/schizoaffective illness.

Official Title
-----------------
Flupenthixol Treatment in Schizophrenic Cocaine Abusers

Conditions
-----------------
Cocaine-Related Disorders

Intervention / Treatment
-----------------
* Drug: Flupenthixol


Participation Criteria
=================
Eligibility Criteria
-----------------
Please contact site for information.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Flupenthixol|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Side effects |  |  | 
| Craving |  |  | 
| Drug use |  |  | 
| Psychiatric symptoms |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
cocaine dependence
Effect of Gluten Free Diet in Patients With Burning Mouth Syndrome

Study Overview
=================
Brief Summary
-----------------
Gluten free diet (GFD) is now being tested in patients affected by schizophrenia, autism and multiple sclerosis, making GFD a possible therapeutic weapon not only for celiac disease or gluten sensitivity. In this protocol we investigate the effect of GFD in patients affected by burning mouth syndrome (BMS), a disease of unknown origin characterized by oral and especially tongue burning sensation, deeply decreasing the quality of life of patients

Official Title
-----------------
Effetto Della Dieta Priva di Glutine in Soggetti Con BMS

Conditions
-----------------
Burning Mouth Syndrome

Intervention / Treatment
-----------------
* Dietary Supplement: Gluten Free Diet
* Dietary Supplement: Normal Diet


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: -Primary BMS Exclusion Criteria: Celiac Disease Psychiatric Disorders intestinal autoimmune diseases Ongoing cancer

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Gluten free diet<br>BMS patients following a GFD | Dietary Supplement: Gluten Free Diet<br> <br> |
| Sham Comparator: Normal Diet<br>Patients with BMS maintaing a normal diet | Dietary Supplement: Normal Diet<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| oral pain | oral pain will be evaluated by means of visual analogue scales | 28 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quality of Life | quality of life of patients with BMS will be evaluated by means of SF36 questionnaire | 28 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Burning Mouth Syndrome, Gluten, Gluten Free Diet
Impedance Pneumography Measurement During Acute Airway Obstruction and Recovery Phase in Young Children

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate the association of signals recorded and analysed with Ventica® LFTS in infants and preschoolers during acute airway obstruction/asthma exacerbation and recovery thereof for changes in the IP-derived TBFV curves within and between nights.

Official Title
-----------------
Impedance Pneumography Measurement During Acute Airway Obstruction and Recovery Phase in Young Children

Conditions
-----------------
Obstruction; Airway, With Asthma

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age 1-7 Diagnosis of acute airway obstruction or asthma exacerbation requiring inpatient treatment Exclusion Criteria: Need for an ICU treatment Bronchiolitis Pneumonia (not including viral infections) Other cardiorespiratory or neurological chronic diseases or states that may significantly alter the overnight breathing pattern Implanted or external active medical devices

Ages Eligible for Study
-----------------
Minimum Age: 1 Year
Maximum Age: 7 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Main group<br>Study has only one group | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Association between clinical status and tidal breathing flow-volume (TBFV) curves | Assess the association between clinical status and changes in tidal breathing flow-volume (TBFV) curves measured overnight with Ventica(R) Lung Function Testing System | 2-4 nights while at ward | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Association between lung function and tidal breathing flow-volume (TBFV) curves | Assess the association between lung function (spirometry or oscillometry) and changes in tidal breathing flow-volume (TBFV) curves measured overnight with Ventica(R) Lung Function Testing System | 2-4 nights while at ward and 2 + 2 nights after discharge from hospital | 
| Association between asthma control and tidal breathing flow-volume (TBFV) curves | Assess the association between asthma control (C-ACT questionnaire) and changes in tidal breathing flow-volume (TBFV) curves measured overnight with Ventica(R) Lung Function Testing System | 2 + 2 nights after discharge from hospital |
Fentanyl 12 Mcg Transdermal Patch For Postoperative Pain

Study Overview
=================
Brief Summary
-----------------
The investigators designed a prospective randomized study to investigate the effect of fentanyl 12 mcg transdermal patch on postoperative pain following unilateral, single-level laminectomy/discectomy.

Official Title
-----------------
The Effect Of Fentanyl 12 Mcg Transdermal Patch On Postoperative Pain Following Unilateral, Single-Level Laminectomy/Discectomy: A Randomized, Controlled, Double-Blind Study

Conditions
-----------------
Postoperative Pain

Intervention / Treatment
-----------------
* Drug: Fentanyl transdermal patch


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients between the ages of 20-70 years ASA physical status 1-2 patients undergoing single-level laminectomy/discectomy Exclusion Criteria: A history of allergy to any study drugs History of opioid use, obstructive sleep apnea Any psychological disorders hepatic or renal failure

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Fentanyl Group<br>Patients received the fentanyl 12 mcg transdermal patch (FG, n=38) 8 hours preoperatively and until 24 hours after the surgery | Drug: Fentanyl transdermal patch<br>* Patients received fentanyl 12 mcg transdermal patch group 8 hours preoperatively and until 24 hours after the surgery<br>|
| No Intervention: Control group<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Numeric rating score for pain (NRS) |  | Postoperative 24 hours |
Adverse Event Risk Assessment in the Use of Nitrous Oxide for Pediatric Dental Patients

Study Overview
=================
Brief Summary
-----------------
The objective was to assess adverse event risk in the use of Nitrous Oxide for Pediatric Dental Patients. The investigators performed a multicenter observational study. The investigators included patients aged 1 to 18 years and who have already failed dental care because of non-cooperation; they could be with mental or cognitive disabilities and could have sedative premedication. The investigators performed any type of dental care With the Use of Nitrous Oxide/Oxygen Sedation. The primary outcome was vomiting assessed during or after dental care.

Official Title
-----------------
Adverse Event Risk Assessment in the Use of Nitrous Oxide for Pediatric Dental Patients

Conditions
-----------------
Dental Carie; Orthodontics

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients under 18 years Use of nitrous oxide/oxygen analgesia/anxiolysis Any type of dental care Exclusion Criteria: Use of midazolam Use of general anesthesia

Ages Eligible for Study
-----------------
Minimum Age: 1 Year
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| occurrence of vomiting |  | from the beginning of Nitrous Oxide/Oxygen administration up to half an hour after the end of dental treatment |