PSG and Neuroendocrine Hormones in Subjective Cognitive Impaired Patients With Transformed Migraine

Study Overview
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Brief Summary
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Transformed migraine is the most common and challenging subtype of chronic daily headache disorders35. Patients with transformed migraine often report an evolutionary process that occurs over months or years in which headaches increase in frequency, change characteristics and ultimately result in patterns of daily or near-daily headaches resembling a mixture of tension-type headache and migraine.

Detailed Description
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The present study aimed to investigate the presence and frequency of cognitive affection in patients with transformed migraines, as well as to analyze the association of cognitive affection with clinical features and headache impact, anxiety, depression, and quality of sleep.

Official Title
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PSG and Neuroendocrine Hormones in Subjective Cognitive Impaired Patients With Transformed Migraine

Conditions
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Migraine

Intervention / Treatment
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* Device: Polysomnography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: -Patients included were adults with clinically confirmed of chronic migraine Exclusion Criteria: Primary headache disorder other than migraine Secondary headache disorders other than medication-overuse headache or unclassified headache, or Aged under 18 years or older than 65 years

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Non-subjective cognitive impaired<br>Cases of migraine and non-subjective cognitive impaired | |
| Subjective cognitive impaired<br>Cases of migraine and subjective cognitive impaired | Device: Polysomnography<br>* PSG was carried out for 41 patients with subjective cognitive impairment and 41 age and sex-matched controls. PSG with standard EEG montage that includes bilateral EOG and four EEG leads were used. A single attended overnight PSG study was performed at the Clinical Neurophysiology Unit of Mansoura University Hospitals. Patients were studied in a quiet, darkened room with no medications were used to induce sleep. All participants underwent one night of laboratory-based PSG.<br>|
| Control group<br>Age and sex matched healthy controls | Device: Polysomnography<br>* PSG was carried out for 41 patients with subjective cognitive impairment and 41 age and sex-matched controls. PSG with standard EEG montage that includes bilateral EOG and four EEG leads were used. A single attended overnight PSG study was performed at the Clinical Neurophysiology Unit of Mansoura University Hospitals. Patients were studied in a quiet, darkened room with no medications were used to induce sleep. All participants underwent one night of laboratory-based PSG.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Polysomnography | PSG was carried out for 41 patients with subjective cognitive impairment and 41 age and sex-matched controls. PSG with standard EEG montage that includes bilateral EOG and four EEG leads were used. A single attended overnight PSG study was performed at the Clinical Neurophysiology Unit of Mansoura University Hospitals. Patients were studied in a quiet, darkened room with no medications were used to induce sleep. All participants underwent one night of laboratory-based PSG. | 24-72 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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MIGRAINE