Association Between COVID-19 and UTIs Caused by ESBL Organism in Infants

Study Overview
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Brief Summary
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Urinary tract infections (UTIs) in infants and young children are one of the most common bacterial infections, usually febrile illness without source, frequently due to Enterobacteriaceae, mainly Escherichia coli. Multidrug-resistant organisms including extended-spectrum beta-lactamase (ESBL) producing bacteria are becoming more prevalent. Due to the risk factors of ESBL-producing organisms in community-acquired (CA)-UTIs in infants in QATAR and Arab countries are still not studied because of the limited therapeutic options. hence, the importance of this study is to get knowledge about how to decrease the rapidly increasing in ESBL- producing bacteria, in infants, and to use antibiotics in a suitable guideline.so, The aim of this retrospective case-control study is to determine the clinical manifestations, and investigations of urinary tract infections among infants and the association with COVID-19 infection, in pediatric emergency centers at Hamad General Hospital - Qatar. From 1st January 2015 till 1st January 2022.

Detailed Description
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In this retrospective, case-control study investigators will include all infants (0-1 year) with UTIs who were treated at Hamad General Hospital, pediatric division- PEC Doha, Qatar, using the electronic medical records from 1st January 2015 till January 1st, 2022, diagnosed by a positive urine culture. Investigators will look for the clinical manifestations, radiological and laboratory findings, renal scarring, ESBL-organisms, prevalence, median age, gender, and ethnic background. Participants are divided into two groups: early infancy and late infancy, ESBL UTIs and non-ESBL UTIs, and upper UTIs and lower UTIs. Finally, UTIs ESBL with COVID-19 and without COVID_19.

Official Title
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Clinical, Laboratory, and Radiological Characteristics of Urinary Tract Infections in Infants With COVID-19

Conditions
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Renal Insufficiency

Intervention / Treatment
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* Other: comparing, prevalence
* Other: assessment
* Other: association
* Other: evaluation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All infants with UTIs who had been treated Exclusion Criteria: Patient with a mixed urine culture.

Ages Eligible for Study
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Maximum Age: 1 Year

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| ESBL UTI<br>all infants with UTIs caused by ESBL producing organisms | Other: comparing, prevalence<br>* Comparing infants with UTIs caused by ESBL organism, or non ESBL organism.<br>* Other names: Data on clinical and laboratory findings are reviewed from medical records for details;|
| Non-ESBL UTI<br>all infants with UTIs caused by non-ESBL producing organisms | Other: assessment<br>* comparing infants with UTIs caused by ESBL organism, or non ESBL organism.<br>|
| ESBL UTI with COVID-19<br>all infants with UTIs caused by ESBL producing organisms with COVID-19 infection | Other: association<br>* comparing ESBLUTI with COVID-19 and ESBL UTI without COVID-19<br>|
| ESBL UTI without COVID-19<br>all infants with UTIs caused by ESBL producing organisms without COVID-19 infection | Other: evaluation<br>* comparing ESBLUTI with COVID-19 and ESBL UTI without COVID-19<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Assessment risk factors , prevalence, and the relation between ESBL UTI and COVID-19 infection of all infants with ESBL- UTIs |  | 1year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Chronic Kidney Diseases, Acute Kidney Injury, UTIs in infants, ESBL UTIs, chronic renal failure, UTIs with COVID-19, ESBL organisms with COVID-19