Compare the Side Effects and Difference Awake Level of Three TCI Propofol Formula in TVOR Patients

Study Overview
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Brief Summary
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This study is to find the fewer side effects formula of anesthesia for TVOR patients, to compare the BIS level during emergence and to find the correlation between BIS and transcutaneous carbon dioxide concentration.

Detailed Description
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Transvaginal oocyte retrieval (TVOR) is a procedure often used in infertility women . During the procedure, sedation, analgesia or anesthesia are often required. Propofol and alfentanyl are used for these patients for years, but these drugs are used in intravenous form and can be found in follicular fluid. Although further investigation needs to be undertaken to investigate any potential influence on fertilization and implantation rates, we anesthesiologist want to lower the use of drugs in these women. Target-controlled infusion (TCI) pumps can estimate and calculate the target and plasma concentration of propofol. By using these pumps , we can estimate the stable concentration of drugs. Besides, Bispectral index (BIS) monitor can help us to evaluate awareness or unarousable amnesia when we turn lower the drug use and keep patients amnesia during the procedure. Transcutaneous carbon dioxide monitor (tcCO2) can mimic the level of CO2 in patients by using noninvasive method. During anesthesia, CO2 will retain and may induce CO2 nacrosis, so we use these noninvasive method to help us to detect CO2 level preventing CO2 nacrosis and to see if there are any relationship with BIS.

Official Title
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Compare the Side Effects and Differences Awake Level of Propofol by Using Three TCI Formula of Anesthesia in TVOR Patients

Conditions
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Bispectral Index, Transcutaneous Carbon Dioxide, PONV, Blood Pressure, Heart Rate

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ASA physical status I or II women age between 25 and 45 y/o participating to receive TVOR Exclusion Criteria: Allergy history to alfentanyl, propofol or lidocaine

Ages Eligible for Study
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Minimum Age: 25 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>pure propofol by TCI pump with titration. | |
| 2<br>10ug/kg alfentanyl bolus and propofol TCI pump infusion with titration | |
| 3<br>20ug/kg alfentanyl bolus and propofol TCI pump infusion with titration | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Vital signs changes and side effects of drugs among groups |  | pre-anesthesia, post-anesthesia, and one hour post-anesthesia | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between transcutaneous carbon dioxide and BIS (bispectral index) |  | From drug infusion stopped to patients awake (per minute) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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target control infusion, alfentanyl, propofol, BIS