Anaesthetic Efficacy of 2% Mepivacaine Versus 4% Articaine With Symptomatic Irreversible Pulpitis

Study Overview
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Brief Summary
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The aim of this randomized, double-blinded, clinical trial was to assess the effect of 3.6 mL 2% mepivacaine hydrochloride with 1:100,000 epinephrine compared to 3.4 mL 4% articaine hydrochloride with 1:100,000 epinephrine on the success of the inferior alveolar nerve block for patients with symptomatic irreversible pulpitis in mandibular molars.

Detailed Description
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The aim of this randomized, double-blinded, clinical trial was to assess the effect of 3.6 mL 2% mepivacaine hydrochloride with 1:100,000 epinephrine compared to 3.4 mL 4% articaine hydrochloride with 1:100,000 epinephrine on the success of the inferior alveolar nerve block for patients with symptomatic irreversible pulpitis in mandibular molars. Patients were clinically and radiographically examined and their eligibility assessed and preoperative pain was measured using the numerical rating scale (NRS). Patients were randomly assigned to one of 2 groups: experimental group (2% mepivacaine) and the control group (4% articaine). After 15 minutes of the inferior alveolar nerve block (IANB), patients reporting lip numbness had their molars accessed. No-to-mild pain response was considered success during root canal preparation.

Official Title
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Anaesthetic Efficacy of 2% Mepivacaine Versus 4% Articaine for Inferior Alveolar Nerve Blocks in Patients With Symptomatic Irreversible Pulpitis in Mandibular Molars: A Randomized Clinical Trial

Conditions
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Symptomatic Irreversible Pulpitis

Intervention / Treatment
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* Drug: Mepivacaine
* Drug: Articaine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients in good health (American Society of Anesthesiologists Class I or II). Patients having symptomatic irreversible pulpitis in one of their mandibular molars. Age range between 18 to 50 years. Patients who can understand Numerical Rating Scale (NRS). Positive patient acceptance and the ability to sign an informed consent. Exclusion Criteria: Pregnant females. Patients allergic to articaine, mepivacaine and/or any used medication or material. Patients having active sites of pathosis in the area of injection. Patients having active pain in more than one molar. Patients who had taken analgesics in the 12 hours preceding treatment.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Mepivacaine<br>IANB using 3.6 ml of 2% mepivacaine hydrochloride with 1:100,000 epinephrine. | Drug: Mepivacaine<br>* IANB using 3.6 ml of 2% mepivacaine hydrochloride with 1:100,000 epinephrine.<br>|
| Active Comparator: Articaine<br>IANB using 3.4 ml of 4% articaine hydrochloride with 1:100,000 epinephrine. | Drug: Articaine<br>* IANB using 3.4 ml of 4% articaine hydrochloride with 1:100,000 epinephrine.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Anaesthetic success | Success of mandibular inferior alveolar nerve block anesthesia during access cavity preparation and instrumentation measured using the 11-point numerical rating scale (NRS) so that no-or-mild pain is considered as anesthetic success and moderate-to-severe pain is considered anesthetic failure. | Intraoperative | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Need for Supplemental anaesthesia | The need for supplemental anaesthesia to complete treatment (Yes/No). | Intraoperative |