Prevalence and Characteristics of Patients With Bronchiectasis Comorbid Nontuberculous Mycobacteria

Study Overview
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Brief Summary
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The purpose of this study is to Understand the prevalence of non-tuberculous mycobacterial(NTM) infections in the middle-aged and old women patients with bronchiectasis in Mainland China, and explore the characteristics of patients with bronchiectasis comorbid NTM.

Detailed Description
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The development of bronchiectasis is closely related to chronic infection of pathogenic microorganisms .Bronchiectasis and nontuberculous mycobacterial (NTM) infections are inextricably linked Pathophysiologically. But the incidence rate and characteristics of NTM infections among patients with bronchiectasis remains unclear in mainland China. In this study, we will collect data of participants about demographic ,co-morbidities ,spirometry, mMRC score ,exacerbation history, QOL-B questionnaire, aetiology, spirometry , HRCT(or CT) scan ,results of microbiology samples and treatments, collect three consecutive sputum(or induced sputum) samples to smear, bacteria culture, acid-fast stain, mycobacterium cultivation and identification, drug susceptibility testing of nontuberculous mycobacteria.To estimate the prevalance of non-tuberculous mycobacterial(NTM) infections in Middle-aged and old women patients with bronchiectasis in northern China. To analyze clinical manifestations and microbiological characteristics of patients with bronchiectasis comorbid NTM infections By 16SRNA and gene sequencing. In addition, A cross-sectional investigation about lung function and clinical data will be done among patients who have confirmed bronchiectasis with NTM from February 2017 to December 2020.

Official Title
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Prevalence and Clinical Characteristics of Patients With Bronchiectasis With Comorbid Nontuberculous Mycobacteria Among Middle-aged and Old Women

Conditions
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Bronchiectasis, Non-tuberculous Mycobacterial

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Middle-aged and old women who are > or = 50 years of age Patients meet the criteria of bronchiectasis Exclusion Criteria: Cystic fibrosis After organ transplantation Activity tumor (malignant solid tumor and blood system tumor) Pulmonary interstitial fibrosis with bronchus dilation Allergic bronchopulmonary aspergillosis Diffuse panbronchiolitis Patients refused to sign the informed consent Patients unable to return sputum specimens

Ages Eligible for Study
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Minimum Age: 50 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| NTM infection rates | NTM infection rates in Middle-aged and old women patients with bronchiectasis in northern China | 24 months afer enrolled participants | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| clinical characteristics of patients with bronchiectasis comorbid NTM infections | clinical manifestations of patients with bronchiectasis comorbid NTM infections | 24 months afer enrolled participants | 
| microbiological characteristics of patients with bronchiectasis comorbid NTM infections | microbiological characteristics of patients with bronchiectasis comorbid NTM | 24 months afer enrolled participants | 
| Drug resistance of NTM | drug susceptibility testing outcomes of nontuberculous mycobacteria from sputum samples | 24 months afer enrolled participants | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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bronchiectasis, NTM infections, Middle-aged and old women