Study of STIM1 Membrane Expression

Study Overview
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Brief Summary
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The aim of this study is to determine the expression of STIM1 in the plasma membrane of lymphocytes from patients suffering from different autoimmune diseases in order to identify new pathologies of interest presenting an over-expression of STIM1PM. This would allow to initiate, following this study, research and development programs on the use of anti-STIM1 antibodies in these identified autoimmune diseases of interest.

Official Title
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Study of STIM1 Membrane Expression During Autoimmune Diseases

Conditions
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Autoimmune Diseases

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosis of one of the autoimmune diseases Exclusion Criteria: Treatment with rituximab in the previous 12 months

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 99 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Myasthénie<br>Blood samples will be collected | |
| Myopathie inflammatoire (Myosite)<br>Blood samples will be collected | |
| Neuropathie autoimmune<br>Blood samples will be collected | |
| Néphropathies autoimmunes<br>Blood samples will be collected | |
| Hépatite auto-immune<br>Blood samples will be collected | |
| Pancréatite auto-immune<br>Blood samples will be collected | |
| Purpura Thrombopénique Immunologique<br>Blood samples will be collected | |
| Dermatose bulleuse<br>Blood samples will be collected | |
| Thyroïdite autoimmune<br>Blood samples will be collected | |
| Sclérose en plaque<br>Blood samples will be collected | |
| Sclérose latérale amyotrophique<br>Blood samples will be collected | |
| Polyarthrite Rhumatoïde<br>Blood samples will be collected | |
| Spondylarthrite axiale<br>Blood samples will be collected | |
| controls<br>Patients without autoimune desease* Blood samples will be collected | |
| Lichen plan buccal auto-immun (LPB)<br>Blood samples will be collected | |
| lichen plan buccal allo-immun liée à une GvHD ( Graft versus Host Disease )<br>Blood samples will be collected | |
| Lupus érythémateux systémique<br>Blood samples will be collected | |
| Sclérodermie<br>Blood samples will be collected | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| level of STIM1-PM | Membrane expression level of STIM1-PM on the surface of immune cells, measured by flow cytometry | Day 0 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| correlation between STIM1 expression and Clinical Score | Study of correlation between STIM1 expression on different cells and clinical scores of different autoimmune diseases or treatments received | Day 0 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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autoimmune diseases