The Effectiveness of Oral Acyclovir in the Treatment of Molluscum Contagiosum in Children

Study Overview
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Brief Summary
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The investigators will study the effectiveness of acyclovir in the treatment of molluscum contagiosum in assiut university hospital - dermatological out patient clinic the treatment group will receive acyclovir 200 mg 5 times per day the controlled group will receive local KOH solution

Detailed Description
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Study population: Site of the study: The outpatient dermatological clinic in Assiut university hospital. Participants: children (2 -16) years' old attending dermatological clinic in Assiut university hospital and their parents. Methodology in details: We will use the social media as  Facebook to invite patient to visit the clinic and follow up them due to the protective measures of covid 19. Diagnosis of the patient with molluscum contagiosum according to the clinical picture Collecting data including personal and clinical data through interviewing the patient and his or her parents Pictures of the lesions will be taken before and after treatment after patient consent. We will Randomly assigning the patient to either treatment group or controlled group according to simple random table Prescribing the treatment according to the patient group Follow up of the patient after 1 weak and each week according to the response to treatment or presence of complication Inclusion criteria: Children (5 -15) years old with Molluscum contagiosum. Exclusion criteria: Molluscum contagiosum with Inflamed spot Known immune compromised children Molluscum lesion in the eye lid. Children with renal impairment.

Official Title
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The Effectiveness of Oral Acyclovir in the Treatment of Molluscum Contagiosum in Children

Conditions
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Molluscum Contagiosum

Intervention / Treatment
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* Drug: Acyclovir
* Drug: KOH 10 %


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Children (2 -16) years old with Molluscum contagiosum. Exclusion Criteria: Molluscum contagiosum with Inflamed spot Known immune compromised children Molluscum lesion in the eye lid. Children with renal impairment.

Ages Eligible for Study
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Minimum Age: 2 Years
Maximum Age: 16 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: treatment group<br>200 mg of oral acyclovir 5 timed per day for 5 days per week for maximum 1 month | Drug: Acyclovir<br>* oral syrp<br>* Other names: Zovirax - Acyclovir;|
| Placebo Comparator: controlled group<br>KOH 10 % solution local application with apiece of cotton 2 time per day maximum for 1 month | Drug: KOH 10 %<br>* solution for local application<br>* Other names: KOH;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The percentage of patient with complete clearance of all molluscum lesions. | we will measure the percentage of patient recovered from all lesion | 3 month for each participant |