linjc16/ctgov huggingface dataset:
Effects of Preventive Treatment for Respiratory Syncytial (RS) Virus Infection During Infancy on Later Atopic Asthma in Preterm Infants

Study Overview
=================
Brief Summary
-----------------
The primary objective of the study is to determine whether the incidence of atopic asthma after three years old may be suppressed in the children who were born as preterm infants and prophylactically treated with palivizumab for respiratory syncytial (RS) virus infections during the infancy. The secondary objective is to determine whether the incidence of recurrent wheezing after three years old may be suppressed in the children who were born as preterm infants and prophylactically treated with palivizumab for RS virus infections during the infancy.

Official Title
-----------------
Cohort Study to Evaluate Effects of Prophylactic Treatment for Respiratory Syncytial (RS) Virus Infection in Respiratory Tract During Infancy on Subsequent Atopic Asthma in Preterm Infants

Conditions
-----------------
Atopic Asthma, Recurrent Wheezing

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Infants born July   December 2007 at 33 35 weeks of gestation Infants administered at least 3 doses of palivizumab during the first 6 months of life (Palivizumab treated) Infants not administered any doses of palivizumab during the first 6 months of life (Palivizumab untreated) Exclusion Criteria: Intrauterine growth retardation (less than -2.5SD) Infants with chronic lung disease (CLD) or other respiratory disease Infants received mechanical ventilation Infants with chronic heart disease (CHD) or congenital anomaly (such as immunodeficiency)

Ages Eligible for Study
-----------------
Minimum Age: 3 Years
Maximum Age: 3 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Treated<br>Palivizumab treated | |
| Untreated<br>Palivizumab untreated | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The incidence of atopic asthma after three years old in the children who were born as preterm infants and prophylactically treated with palivizumab for RS virus infections during the infancy |  | For three years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The incidence of recurrent wheezing after three years old in the children who were born as preterm infants and prophylactically treated with palivizumab for RS virus infections during the infancy |  | For three years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
atopic asthma, recurrent wheezing, preterm infants, palivizumab, respiratory syncytial virus, RSV
Physiotherapy-led Outpatient Clinic for Patients With Spondyloarthritis

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine whether patients with spondyloarthritis are more satisfied with a physiotherapy-led outpatient clinic than usual care and whether there is a difference between patients in a physiotherapy-led outpatient clinic and those in usual care regarding disease activity, function and mobility.

Official Title
-----------------
Physiotherapy-led Outpatient Clinic for Patients With Spondyloarthritis

Conditions
-----------------
Spondylarthritis, Spondylitis, Ankylosing, Spondylarthropathies, Sacroiliitis, Arthritis, Psoriatic

Intervention / Treatment
-----------------
* Other: Physiotherapy follow-up


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: confirmed diagnosis spondyloarthritis, ankylosing spondylitis, spondylarthropathy, juvenile ankylosing spondylitis, psoriatic arthritis with affection of the spine age between 18 and 45 (born 1969 - 1996) Exclusion Criteria: also diagnosed with potentially functionally impairing neuromuscular, neurological or muscular disorders insufficient Norwegian language skills cognitive impairment no sign of inflammation or bone erosions in the sacroiliac joints or in the spine on imaging

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Physiotherapy follow-up<br>Consultation at Physiotherapy-led Outpatient Clinic every 4 month. | Other: Physiotherapy follow-up<br>* Physiotherapy consultation every 4 months containing assessment of the spine and its mobility, including axial joints, assessment of the patients activity profile. Instruction in home-exercises and recommendations for optimization of activity profile. Information regarding the disease and the importance of physical activity and exercise.<br>|
| No Intervention: Usual care<br>Consultation every 4 months, twice a year by rheumatologist as usual, once a year by nurse. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Leeds Patient Satisfaction Questionnaire (LSQ) |  | 8 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Bath Ankylosing Spondylitis Metrology Index (BASMI) |  | 8 months | 
| Bath Ankylosing Spondylitis Functional Index (BASFI) |  | 8 months | 
| Ankylosing Spondylitis Disease Activity Score (ASDAS) |  | 8 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Physiotherapy, Outpatient clinic
EUS-Elastography and Contrast-Enhanced EUS Diagnostic Accuracy in the Differential Diagnosis of Subepithelial Gastrointestinal Tumors

Study Overview
=================
Brief Summary
-----------------
The differentiation among the Gastrointestinal Subepithelial Tumors (SETs) represents a clinical challenge. Endoscopic Ultrasound (EUS) alone may be ineffective in differentiating SETs subtypes, and tissue sampling of these lesions may be technically difficult. EUS Elastography (EUS-E) has been applied to many gastrointestinal diseases, providing a qualitative/semi-quantitative stiffness analysis, but only few studies have examined the role of EUS-E in the diagnosis of SETs. In addition, the use of contrast agents has improved the diagnostic performance of the EUS, especially in the differentiation between GISTs and other gastrointestinal SETs. The aim of the study is to examine the performance of EUS-E and Contrast Enhanced-EUS (CE-EUS) in distinguishing among different gastrointestinal SETs subtypes. EUS patterns of different techniques will be compared to the final diagnosis gained by the analysis of histopatological specimens (surgical resection or EUS-FNB) or imaging/clinical follow-up.

Official Title
-----------------
EUS-Elastography and Contrast-Enhanced EUS Diagnostic Accuracy in the Differential Diagnosis of Subepithelial Gastrointestinal Tumors: a Multicenter Prospective Observational Study

Conditions
-----------------
Gastrointestinal Subepithelial Tumors

Intervention / Treatment
-----------------
* Procedure: EUS-FNB


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with GI SETs scheduled for EUS-FNB Patients with age > 18 but <85 years Exclusion Criteria: Patients with GI SETs <15mm severe coagulopathy defined as abnormal prothrombin time (PT) or partial thromboplastin time (PTT) that does not normalize after administration of fresh frozen plasma severe cardiopulmonary diseases and severe chronic kidney disease defined as glomerular filtration rate (GFR) < 15 ml/min known allergic disposition to SonoVue® pregnancy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: EUS-FNB|Endoscopic ultrasound (EUS)-guided fine needle biopsy (FNB)|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| EUS-E accuracy in terms of qualitative and quantitative elastography | Evaluation of EUS-E accuracy (qualitative and quantitative elastography) and contrast enhanced endoscopic ultrasound (CE-EUS) in the diagnosis of SETs. | 24 months |
Feasibility and Safety of Ultrasound Guided Installation Central Subclavian Catheter Through Supraclavicular Way

Study Overview
=================
Brief Summary
-----------------
Our goal is to demonstrate the feasibility of laying uncomplicated ultrasound-guided central subclavian catheter by supraclavicular route in the newborn.

Official Title
-----------------
Feasibility and Safety of Ultrasound Guided Installation Central Subclavian Catheter Through Supraclavicular Way

Conditions
-----------------
Heart Diseases, Diseases, Metabolic

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patient hospitalized in the neonatal intensive care or neonatal intensive care at the University Hospital of Hautepierre All infants less than 44 weeks corrected age who require a surgical approach In the first line if neonate over 34 weeks corrected age requiring dual carriageway catheter After Failure or inability laying KTEC for children between 30 and 34 weeks of age corrected and heavy over 1000 Exclusion Criteria: Nouveau-né de poids < 1000g Nouveau-né de moins de 30 semaines d'âge corrigé Choix d'une autre voie d'abord plus judicieux (KTVO, KTC broviac) Sortie avant retrait du KTC

Ages Eligible for Study
-----------------
Minimum Age: 43 Weeks
Maximum Age: 44 Weeks

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| success rate without complications laying catheter ultrasound guided subclavian by supraclavicular route in newborn |  | 1h after intervention |
Inflammatory Mediators of Acute Kidney Injury in Intensive Care

Study Overview
=================
Brief Summary
-----------------
Acute kidney injury (AKI) affects more than 50% of patients admitted to the intensive care unit. The most common underlying cause is sepsis. Severe AKI in combination with sepsis is associated with high mortality. The mechanisms for sepsis-induced AKI are largely unknown. Our hypothesis is that the inflammatory response to an infection cause collateral damage to host tissue and contributes to the development of AKI. In this study we want to investigate the presence of novel inflammatory mediators in patients with sepsis, patients subjected to major surgery (sterile inflammation) and non-inflamed patients and correlate their levels with the risk for AKI.

Official Title
-----------------
Prospective Studie of Inflammatory Markers in Urine, Plasma and Sputum Associated With Acute Kidney Injury

Conditions
-----------------
Sepsis, Surgery, Acute Kidney Injury

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients admitted to the intensive/post operative care unit with septic shock or post major surgery or after intoxication with a chemical compund Exclusion Criteria: Pregnancy or Breast feeding or Chronic kidney disease or intoxication with nephrotoxic compund or lack of informed consent

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Sepsis<br>Patients admitted to the intensive care unit with sepsis | |
| Surgery<br>Patinets subjected to major surgery and then admitted to the intensive care unit | |
| Non-inflamed<br>Otherwise healthy patients admitted to the intensive care unit because of intoxication. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Histones | Correlation between levels of histones and degree of acute kidney injury | Within 1 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Other inflammtory mediators | Correlation between levels of other inflammtory mediators and degree of acute kidney injury | Within 1 month |
Metabolism of Patients With Genetically Caused Cardiac Arrhythmia

Study Overview
=================
Brief Summary
-----------------
Loss-of-function mutations in voltage-gated potassium channels cause long QT syndrome (LQTS) due to a prolonged cardiac repolarisation phase. Hypoteses: patients with loss-of-function mutations also exhibit altered hormone release upon glucose ingestion.

Detailed Description
-----------------
Loss-of-function mutations in voltage-gated potassium channels cause long QT syndrome (LQTS) due to a prolonged cardiac repolarisation phase. Voltage-gated potassium (Kv-) channels are known for their relation to malignant cardiac arrhythmias, but also play a role in pancreatic alpha- and beta cell hormone secretion, and possibly in incretin hormone secretion. We hypothesised that patients with loss-of-function mutations also exhibit altered hormone release upon glucose ingestion.

Official Title
-----------------
Metabolism of Patients With Genetically Caused Cardiac Arrhythmia

Conditions
-----------------
Long QT Syndrome

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: LQTS Gain of function Matched healthy controls Exclusion criteria: none

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Mutation<br>Patients with functional mutation in ion channels | |
| Control<br>Matched control | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| glucose homeostasis | measured by glucose, insulin, glucagon, GLP-1 and GIP response to glucose (OGTT) | 6 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| QT | cardiac repolarisation | 6 hours |
Assessment of the Stroke Rehabilitation Assessment of Movement as a Clinical Tool

Study Overview
=================
Brief Summary
-----------------
The Stroke Rehabilitation Assessment of Movement (STREAM) is a relatively new measurement tool, which measures specific movement deficits (impairments) caused by a stroke. The STREAM is used to evaluate recovery of voluntary movement and basic mobility following the onset of a stroke. Several important clinical measurement properties of the STREAM remain to be explored, including its ability to measure impairments and clinical change in acute rehabilitation patients in the USA. We hypothesize that the STREAM will be able to detect and quantify a statistically significant change in the motor abilities of stroke patients from admission to discharge. An additional aim of the study is to compare the STREAM with two accepted and widely used clinical measures of function and disability, the Stroke Impact Scale (SIS)and the Functional Independence Measure (FIM). By linking movement deficits that are commonly assessed by physical therapists with measures of function and disability, the impact of the movement deficits can be understood.

Official Title
-----------------
A Comparison of the Stroke Rehabilitation Assessment of Movement, the Functional Independence Measure and the Stroke Impact Scale

Conditions
-----------------
Stroke

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: comprehension of English age 18 and older first-time stroke receiving in-patient rehabilitation at the Rusk Institute of Rehabilitation Medicine, New York, NY Exclusion Criteria: hemorrhagic stroke brain stem or cerebellar infarct other pre-existing neurologic conditions

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Stroke Rehabilitation Assessment of Movement (STREAM) | The STREAM measures quality of movements in the arm and leg, and the quality of mobility during important functional tasks, such as walking 10 feet. There are 10 items for each of the 3 assessments (arm, leg and mobility), resulting in a total of 30 items. Each item is rated on a scale of 0 = unable to perform, to 2 or 3 = normal movement. Ratings on the 30 items are added together for a total score which is divided by the total number of items resulting in a percentage score: minimum=0, maximum=100, range=100 The score reported is mean +/- standard deviation of discharge STREAM scores. | 4 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
function, disability
Validation of an Automatic Analysis Algorithm of the Probability of Glaucoma From Optic Disc Images

Study Overview
=================
Brief Summary
-----------------
Clinical, cross-sectional and prospective study to assess the images of the posterior pole of the retina of patients from the Glaucoma Unit of the IOBA and the Hospital Clínico Universitario de Valladolid during the period between May and December 2021. The aim of the project is to provide a sufficient number of images from posterior pole retinographies in patients with suspected glaucoma or with diagnosis of glaucoma in order to determine the sensitivity and specificity of an automatic glaucoma screening algorithm developed by the company Transmural Biotech S.L.

Official Title
-----------------
Validation of an Automatic Analysis Algorithm of the Probability of Glaucoma From Optic Disc Images

Conditions
-----------------
Glaucoma, Suspect, Glaucoma, Ocular Hypertension

Intervention / Treatment
-----------------
* Diagnostic Test: Fundus Photographs (retinographies)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Primary open angle glaucoma or ocular hypertension Signed informed consent Visual field examination within the last 12 months Exclusion Criteria: Ocular or systemic pathologies that may interfere with the quality of the retinographic image or the results of the visual field Congenital anomalies of the papilla that seriously alter its structure High ametropia (> 10 diopters) Pharmacological Mydriasis contraindication.

Ages Eligible for Study
-----------------
Minimum Age: 40 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Glaucoma<br>People with diagnosis of Primary Open Angle Glaucoma (POAG) | Diagnostic Test: Fundus Photographs (retinographies)<br>* Fundus photographs under mydriasis<br>|
| Ocular Hypertension / glaucoma suspect<br>People with diagnosis of Ocular Hypertension or POAG suspicion | Diagnostic Test: Fundus Photographs (retinographies)<br>* Fundus photographs under mydriasis<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sensitivity and Specificity of an automated classification system for retinographies |  | Day 0 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Deep Learning, Diagnoses Disease, Glaucoma, retinographies
Ribose and Sport Performance

Study Overview
=================
Brief Summary
-----------------
Investigate the acute effect of ribose supplementation on performance and recovery in athletes.

Official Title
-----------------
The Effect of Ribose on Performance and Recovery in Athletes

Conditions
-----------------
Sports

Intervention / Treatment
-----------------
* Other: Ribose
* Other: Placebo


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Men and women Training volume > 7hrs/week VO2 max > 40 and 45 mg/kg/min (for women and men respectively) Otherwise healthy individuals Exclusion Criteria: Pregnant or breastfeeding women Individuals with endocrine disorders, hypercholesterolemia, cardiovascular diseases, gut diseases, cancer, anemia, hypoglycemia Medication for lipids, diabetes, hypertension, inflammation, autoimmune diseases, mood disorders Excessive alcohol consumption (more than two drinks by day for men, one for women), smoking, drug use, supplements or natural products consumption during the study

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Ribose<br>After each of the 3km time trial (3 in total), consumption of ribose incorporated in a sports drink. | Other: Ribose<br>* After each of the 3km time trial (3 in total), participants will be asked to drink the experimental product (or placebo) incorporated in a sports drink.<br>|
| Placebo Comparator: Placebo<br>After each of the 3km time trial (3 in total), consumption of placebo incorporated in a sports drink. | Other: Placebo<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in time to complete the third of 3 consecutive 3km time trials on bike |  | baseline and 1 week | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Performance on the 3 consecutive 3km time trials on bike | Performance measures: peak power (watts/kg), mean power (watts/kg), time to peak power (sec), total work (kJ) and maximum cadence (RPMmax) | baseline and 1 week | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Peak VO2 consumption, 3km time trial, fatigue perception, lactate, time to complete