Exploration of Neuroimaging and Biochemical Prognostic Indicators for POCD

Study Overview
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Brief Summary
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Postoperative cognitive dysfunction (POCD) may lead to serious consequences. But the underlying mechanisms are still unclear. Blood Oxygen Level Dependent (BOLD) fMRI and biochemical indicators will be used to explore the underlying mechanisms and represent a promising precursory target for diagnosis and treatment of POCD.

Detailed Description
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Postoperative cognitive dysfunction (POCD) is one of the most common complications in patients undergoing cardiac surgery. POCD will not only increase the incidence of complications and mortality, but also influence the quality of life after discharging from the hospital. Many factors are associated with POCD, such as neuroinflammation, age, anesthetics, surgery stress response and genetic factors. But the underlying mechanisms are still unclear. Blood Oxygen Level Dependent (BOLD) fMRI, which could monitor the peripheral neuron spontaneous activity according to the ratio of oxyhemoglobin and deaeration hemoglobin in blood, will be used to investigate whether POCD is induced by the variance in neurons metabolism and spontaneous activity in brain regions. Meanwhile, biochemical indicators will be detected to explore the prompting indicators of POCD. The present study is aimed to represent a promising precursory target for diagnosis and treatment of POCD, and provide novel evidence and insights on the brain changes induced by POCD.

Official Title
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Exploration of Neuroimaging and Biochemical Prognostic Indicators for Post-operative Cognitive Dysfunction After Coronary Artery Bypass Graft

Conditions
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Postoperative Cognitive Dysfunction, Cognitive Impairment

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Aged 18-80 years old Underwent selective CABG surgery Exclusion Criteria: History of central nervous system or psychiatric disorders History of taking sedative, antidepressants, or alcoholism MMSE score less than 23 Visual or auditory disorders Educated less than 7 years Claustrophobia Can not be supine Can not tolerate iodinated contrast agents

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The brain structure changes | Using BOLD fMRI to investigate the variance of mean diffusivity and FA in nerve conduction bundle | 7 days postoperatively | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mini-Mental State Examination | Application of digital depth and breadth to test digital sign test Tracking the attachment test and assess depression self rating scale | preoperative and 7 days, 3 months and 1 years postoperative | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Inflammation, Coronary artery bypass graft, Magnetic Resonance Imaging