Use of Probiotic Yogurt in Obese Women

Study Overview
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Brief Summary
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This study aimed to examine the effects of using probiotic yogurt on body components (body weight, height, etc.) and digestive system (distention, gas, etc.) in obesity (obese women), which is an important public health problem all over the world.

Detailed Description
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Obesity is an important public health problem worldwide and is associated with non-communicable diseases such as Type 2 Diabetes, hypertension, coronary heart disease, hyperlipidemia, non-alcoholic fatty liver, some neoplasms, and infertility disease.However, it is supported by the literature that nutrition and obesity cause microbial dysbiosis. In this study, it was aimed to use probiotics and yogurt with the thought that nutrition can manipulate the microbiota. It was aimed to investigate the effects of probiotic yogurt consumption on anthropometric measurements, metabolic parameters, and gastrointestinal symptoms in obese women (25-45 years old) with the prospective method. The study was carried out in patients who were diagnosed with obesity by the doctor, consulted the Dietitian, and accepted + signed the voluntary consent form. Total data and measurements were followed and recorded by the same Dietitian. Compliance with medical nutrition therapy, recording of scales were followed weekly.Patients diagnosed with COVID-19 during the study were excluded from the study.

Official Title
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The Effect of Using Probiotic Yogurt on Anthropometric Measurements and Gastrointestinal System in Obese Women

Conditions
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Obesity, Dysbioses

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Female patients aged 25-45 years, with a BMI of 27-35 kg/m2 diagnosed as obese by the doctor Female patients without a chronic disease Female patients between the ages of 25-45 with regular menstrual cycles, Female patients between the ages of 25-45 who are not pregnant or lactating Female patients who do not use drugs, herbal products, etc. nutritional supplements. Exclusion Criteria: Patients with BMI≥ 36 kg/m2 Patients with diabetes, gastrointestinal diseases, CRF, etc. Women in pregnancy and lactation period, Male patients Weight loss medicine etc. patients with drug use Patients who use antibiotics Patients using probiotics, propolis, herbal products, etc. Patients with menstrual irregularity Female patients who have entered the menopause

Ages Eligible for Study
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Minimum Age: 25 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Obese Group<br>A single sample group . Anthropometric measurements were taken at the beginning of all patients. Yogurt with probiotic added to medical nutrition therapy was applied for 2 weeks.Anthropometric measurements were taken at the beginning of all patients. Yogurt with probiotic added to medical nutrition therapy was applied for 2 weeks. At the end of each week, food consumption records and scales were applied. During the wash out period, all patients were asked to comply with their diet only. After the wash out period, a different diet was started and the same procedures were repeated.During the wash out period, all patients were asked to comply with their diet only. After the wash out period, a different diet (with the addition of probiotic yogurt) was changed and the same procedures were repeated. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Determining Change in Obesity | Mean percent change in initial and final body weight (kilogram) Mean percent change initial and final waist circumference (cm): Mean percent change initial and final waist/height ratio: It will be calculated by dividing waist circumference by height. The cut-off point of ratio will be taken as 0.5. Mean percent change initial and final waist/hip ratio:The cut-off point for the Waist/Hip ratio, which was determined by dividing the waist circumference by the hip circumference, was determined as ≥0.90 cm for men and ≥0.85 cm for women. Mean percent change initial and final fat mass: It measurement of individuals will be measured with the Body Composition Analyzer (in % and kg units). It is based on the difference in electrical permeability of fat-free tissue mass and fat. Biochemical parameters was determined in mg/dL following the protocols established for: high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides and fasting glucose. | 1 time per week/5 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes on the Gastrointestinal System | Evaluation of the difference between individuals according to the Bristol Stool Scale. The Bristol Stool Scale is used to determine stool. The scale has seven stool types for visual identification of stool. Gastrointestinal Symptom Rating Scale:The scale, which consists of 15 questions, includes questions about abdominal pain, heartburn, reflux nausea, dyspepsia and stool consistency. | 1 time per week/5 weeks |