Effect of Ascites Replacement Strategy on Time to 1st Flatus After LDLT

Study Overview
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Brief Summary
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The aim of this study is to evaluate difference in the rate of recovery of intestinal motility according to different ascites replacement strategy after living donor liver transplantation.

Official Title
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Effect of Albumin Administration Strategy for Ascites Replacement on Time to 1st Flatus After Liver Transplantation

Conditions
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Living Donor Liver Transplantation

Intervention / Treatment
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* Drug: Ascites replacement with albumin and hartmann's solution
* Drug: Ascites replacement with hartmann's solution


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adults (19 years or older) Elective living donor liver transplantation Exclusion Criteria: Previous abdominal surgery Renal failure requiring renal replacement therapy Contraindications for 5% albumin use Condition with potential risk caused by increased circulating plasma (heart failure, renal failure combined with oliguria, pulmonary edema) Hemolytic anemia Contraindications for Hartmann solution Progressive lactic acidosis Hypervolemia Hypernatremia

Ages Eligible for Study
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Minimum Age: 19 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Replacement with albumin<br>Check drain amount every 4 hour after SICU admission Replacement of 70% of drainage from previous 4 hours over next 4 hours 30% of the drainage with 5% albumin 40% of drainage with Hartmann's solution If, serum K + level> 5mEq/L, replace with 0.9% saline instead of Hartmann solution If, serum albumin level is below 2.6 g/dL, inject 100mL of 20% albumin | Drug: Ascites replacement with albumin and hartmann's solution<br>* Combined strategy for ascites replacement 30% of ascites: replacement with 5% albumin 40% of ascites: replacement with Hartmann's solution<br>* Other names: Experimental;|
| Active Comparator: Replacement with Hartmann's solution<br>Check drain amount every 4 hour after SICU admission Replacement of 70% of drainage from previous 4 hours with Hartmann's solution over next 4 hours If, serum K + level> 5mEq/L, replace with 0.9% saline instead of Hartmann solution If, serum albumin level is below 2.6 g/dL, inject 100mL of 20% albumin | Drug: Ascites replacement with hartmann's solution<br>* Hartmann's solution only strategy for ascites replacement - 70% of ascites: replacement with Hartmann's solution<br>* Other names: No intervention;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time to 1st flatus | Interval between SICU admission and 1st flatus | within 4 weeks | 
| Time to 1st diet | Interval between SICU admission and 1st diet | within 4 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Ascites, Albumin, Hartmann's solution, Postoperative ileus