Biological Risk Factors for Onset of Binge Eating and Compensatory Behaviors

Study Overview
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Brief Summary
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The purpose of this proposed project is to test whether several biological factors (such as elevated brain reward region and attention region response to high-calorie foods, weaker inhibitory region response to high-calorie foods, habitual caloric deprivation, and elevated limbic region responsivity) increase the risk of problematic eating (bingeing and purging) in female adolescents.

Detailed Description
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Participants will be adolescent girls aged 13-16, some of whom will have parental history of eating pathology. Participants will be recruited from the general population but their age, gender, and the presence of parental lifetime eating pathology will create a high-risk sample. The goals of the proposed project are to (1) conduct a prospective high-risk study to test whether proposed biological risk factors predict the future onset of core ED symptoms (e.g., binge eating, compensatory behaviors); (2) test hypotheses regarding how these biological risk factors and established self-report ED risk factors may work together to predict ED behavior onset; (3) examine if certain biological factors account for the effects of certain established self-reported ED risk factors (e.g., elevated brain response to thin models accounts for the effect of questionnaire-measured thin-ideal internalization). The participants will complete a baseline assessment and then follow-ups assessments over a span of three years. In addition, participants will complete one fMRI scan after the first assessment. During the COVID-19 shelter-at-home order, the investigators will not measure in person only outcomes including fMRI scans, height and weight measurement for BMI calculation nor IAT computer paradigms for all participants that have assessments due during this order.

Official Title
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Biological Risk Factors for Onset of Binge Eating and Compensatory Behaviors

Conditions
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Eating Disorder

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Female Aged 13-16 years Exclusion Criteria: Adolescents who report functional magnetic resonance imaging (fMRI) contraindications Current Diagnostic and Statistical Manual of Mental Disorders 5 (DSM-5) substance abuse disorder, eating disorder (ED), conduct disorder, attention deficit hyperactivity disorder (ADHD), or bipolar disorder Weekly or greater use of psychoactive drugs (e.g., analgesics, cocaine, marijuana) Serious medical complications (e.g., cancer, diabetes) History of head injury Relevant food allergies BMI > 35

Ages Eligible for Study
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Minimum Age: 13 Years
Maximum Age: 16 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| High Risk Group<br>Parental history of eating pathology | |
| Low Risk Group<br>No parental history of eating pathology | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in binge eating behaviors using the EDDI | Eating Disorder Diagnostic Interview (EDDI) | 6 months, 1 year, 2 year, and 3 year follow-up | 
| Change in compensatory behaviors using the EDDI | Eating Disorder Diagnostic Interview (EDDI) | 6 months, 1 year, 2 year, and 3 year follow-up | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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fMRI, Eating disorder, adolescent