Oxidative Stress in Response to Electroacupuncture Against Physical Activity in Diabetic Patients

Study Overview
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Brief Summary
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OS is an important pathogenetic mechanism for the development of T2DM and its complications. Oxidative stress is an imbalance of the generation of free radicals or known as reactive oxygen species (ROS) and reactive nitrogen species [RNS]) and their neutralization by the antioxidant mechanisms. Increased levels of ROS and RNS lead to damage of lipids, proteins, and DNA, ultimately causing the destruction of the islet cells of pancreas through apoptosis . Elliptical trainer device is a relatively new modality of exercise and is advertised to be superior to a treadmill because of the low joint impact and the more reasonable costs of an elliptical trainer compared to a treadmill . Additional quantative research is needed to further evaluate the effectiveness of elliptical trainers and the physiological and perceptual responses to the machine Electroacupuncture (EA) is a treatment form of traditional acupuncture in which small electrical currents are passed through needles inserted into the subject's skin using EA stimulator. It seems to have more acceptable results and effects on many important clinical applications and medical research sets .

Detailed Description
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60 diabetic patients will be randomly divided to electroacupucture group (30 patients) and high intensity elliptical training (30 patients). the treatment will be done for 5 sessions per week for 12 weeks

Official Title
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Markers of Oxidative Stress in Response to Electroacupuncture Against Aerobic Physical Activity in Diabetic Patients

Conditions
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Diabetes Mellitus, Type 2

Intervention / Treatment
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* Device: high intensity elliptical training
* Device: electrocaupuncture


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: type 2 diabetic elderly Body mass index less than 30 kg/m2. Fasting blood more than 126 mg/dl Exclusion Criteria: cardiac patients renal patients respiratory patients liver patients patients who received any complementary therapies within 3 past months

Ages Eligible for Study
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Minimum Age: 65 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Exercised group<br>30 patients will receive 30 minutes of high intensity interval training on elliptical trainer, 5 times per week, for 12 week | Device: high intensity elliptical training<br>* 30 patients will receive 30 minutes of high intensity interval training on elliptical trainer, 5 times per week, for 12 week<br>|
| Active Comparator: group of electroacupuncture<br>30 patients will receive 30 minutes of electroacupuncture on bilateral PC 4 and PC 6, 5 times per week, for 12 week | Device: electrocaupuncture<br>* 30 patients will receive 30 minutes of electroacupuncture on bilateral PC 4 and PC 6 for 5 times per week, for 12 week<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| superoxide dismutase | marker of anti-oxidative stress | It will be measured after 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| nitric oxide | will be measured in plasma | It will be measured after 12 weeks | 
| lipid hydroperoxidase | will be measured in plasma | It will be measured after 12-week training |