Study of Electroencephalogram (EEG) Measurement During Different Stimulations of the Lower Urinary Tract

Study Overview
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Brief Summary
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The purpose of this study is to investigate afferent and cortical activities during bladder filling under different stimulations of the lower urinary tract. The participants of the study are healthy test persons and patients with overactive bladder.

Official Title
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Investigation of Lower Urinary Tract Afferent and Cortical Brain Activity During Lower Urinary Tract Stimulation Using Electroencephalogram Measurements

Conditions
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Healthy, Nonneurogenic Neurogenic Bladder Dysfunction, Neurogenic Bladder Dysfunction Nos

Intervention / Treatment
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* Other: Electroencephalography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Right-handed Written informed consent Exclusion Criteria: Any psychological diseases Any renal, cardiac, and pulmonary diseases Pregnancy or breastfeeding Problems keeping calm for 60 minutes in the sitting position Medication influencing EEG or bladder function

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: healthy testpersons<br>Electroencephalography recording during electrical stimulation of different locations of the lower urinary tract as well as during electrical and heat stimulation at the tibial and pudendal nerve and S3 dermatome. | Other: Electroencephalography<br>* Standard electroencephalography investigation according to the ICS standard Current recording of latency and amplitude of evoked potentials<br>|
| Experimental: patients with non-neurogenic OAB<br>Electroencephalography recording during electrical stimulation of different locations of the lower urinary tract as well as during electrical and heat stimulation at the tibial and pudendal nerve and S3 dermatome. | Other: Electroencephalography<br>* Standard electroencephalography investigation according to the ICS standard Current recording of latency and amplitude of evoked potentials<br>|
| Other: patients with neurogenic OAB<br>Electroencephalography recording during electrical stimulation of different locations of the lower urinary tract as well as during electrical and heat stimulation at the tibial and pudendal nerve and S3 dermatome | Other: Electroencephalography<br>* Standard electroencephalography investigation according to the ICS standard Current recording of latency and amplitude of evoked potentials<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Establishment of somatosensory evoked potentials of lower urinary tract stimulations | EEG recording during electrical stimulation of different locations of the lower urinary tract as well as during electrical and heat stimulation at the tibial and pudendal nerve and S3 dermatome. | 3 times on an average period of three months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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lower urinary tract, sensory evoked potential, contact heat evoked potential stimulation, electroencephalogram, cortical processing, bladder sensations, lower urinary tract dysfunction, overactive bladder