Role of Chest Ultrasound in Diagnosing and Follow-up of Pneumonia

Study Overview
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Brief Summary
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The study of a large number of patients (at least 200 patients) from several European centres aims to investigate the value of chest ultrasound in diagnosing and checking the course of pneumonia as compared to a chest X-ray film in two planes and - in case of a controversial X-ray finding- as compared to low-dose CT. An X-ray finding is regarded controversial, if infiltrates cannot be reliably excluded or not reliably represented and if a definite diagnosis is, thus, not possible. A low-dose CT is indicated even in case of a positive chest ultrasound and negative X-ray finding. Sonographic recording and characterization of pneumonic infiltrates is performed both at the time of diagnosing and in the further course under therapy.

Detailed Description
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The primary target criterion is • Assessing the sensitivity of chest ultrasound in diagnosing pneumonia. Secondary target criteria comprise Assessing specificity, negative and positive predictive value of chest ultrasound at the time of diagnosing, Characterizing pneumonic infiltrates at the time of diagnosing and further course, Describing the association between clinical, X-ray and sonographic findings in the course of pneumonia. The tertiary target criterion includes • Characterizing the range of pathogens detected by microbiological examination.

Official Title
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Role of Chest Ultrasound in Diagnosing and Follow-up of Pneumonia. Prospective Comparison Between X-ray Chest Film in Two Planes and Low-dose Spiral Computed Tomography

Conditions
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Pneumonia

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with clinically suspected CAP who received no antibiotic treatment yet Patients in whom a chest X-ray in 2 planes was already performed, can be included in the study, if chest ultrasound is performed within 24 hours after X-ray and if the X-ray finding is neither available to nor known to the examiner doing the ultrasound examination. Age > 18 years Patient's declaration of consent is available. Exclusion Criteria: Patients with HAP Age <18 years Patients in whom the time difference between chest ultrasound and chest X-ray in 2 planes is more than 24 hours Patients whose X-ray findings are with the examiner doing the ultrasound or are known to him Pregnancy and lactation Missing declaration of consent by the patient.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| patients with suspected pneumonia<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| sensitivity of chest ultrasound in diagnosing pneumonia |  | baseline diagnostic | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Specificity |  | baseline diagnostic | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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chest ultrasound, pneumonia, X-ray, CT, Sensitivity and specificity of chest ultrasound in diagnosing pneumonia