Risk Communication in African American Smokers

Study Overview
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Brief Summary
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The study aims to understand the effects of learning about one's genetic risk for lung cancer that is specific to their ancestry. Participants will be given hypothetical personalized genetic risk results and ask to think about how they might respond to such information if they actually received such results.

Detailed Description
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The study aims to understand the effects of learning about one's genetic risk for lung cancer that is specific to their ancestry. Smokers will be randomized to receive hypothetical information about their genetic status and consider how they think they would respond if such results were actually presented to them. They will be randomly assigned to receive one of four sets of hypothetical genetic results: 1) High risk of lung cancer and high genetic African ancestry, 2) High risk of lung cancer and low genetic African ancestry, 3) Low risk of lung cancer and high genetic African ancestry, or 4) Low risk of lung cancer and low genetic African ancestry. After being given this hypothetical information, participants will complete brief questionnaires assessing perceived risk of lung cancer, worry about cancer, psychological distress, and motivation to quit smoking.

Official Title
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Nicotine Dependence and Lung Cancer Genetics in African Americans

Conditions
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Lung Cancer

Intervention / Treatment
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* Behavioral: HRHA
* Behavioral: LRLA
* Behavioral: HRLA
* Behavioral: LRHA


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 18 years of age minimum Self-report African American Report smoking at least 100 lifetime cigarettes Exclusion Criteria: Report history of cancer

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: HRHA<br>High Risk, High Ancestry | Behavioral: HRHA<br>* participants will be asked to consider a hypothetical scenario in which genetic test results reveal that: 1) they carry genotypes that place African American smokers at a particularly high ( 50%-80%) risk for the development of lung cancer, and 2) their genetic profile reflects a particularly high concordance with African heritage ( 90%).<br>|
| Experimental: LRLA<br>Low Risk, Low Ancestry | Behavioral: LRLA<br>* participants will be asked to consider a scenario in which genetic test results reveal that: 1) they are at normal ( 7%-10%) risk for the development of lung cancer, and 2) their genetic profile reflects a particularly low concordance with African heritage ( 10%).<br>|
| Experimental: HRLA<br>High Risk, Low Ancestry | Behavioral: HRLA<br>* participants will receive High Risk, Low Ancestry (HRLA) hypothetical<br>|
| Experimental: LRHA<br>Low Risk, High Ancestry | Behavioral: LRHA<br>* participants will receive Low Risk, High Ancestry (HRLA) hypothetical<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Motivation to Quit Smoking | use self report 7 item (condition options) MTSS (Motivation to Stop Smoking) Scale with yes/no option to determine the quitting intention condition; range of scale : 1-7, with higher score means higher motivation to quit smoking | 1 minute after intervention |