Antimicrobial Photodynamic Therapy in Treatment of Aggressive Periodontitis (Stage III, Grade C Periodontitis)

Study Overview
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Brief Summary
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Treatment of aggressive periodontitis (stage III, grade C periodontitis) represents a big challenge. The aim of the study was to compare the long-term results of antimicrobial photodynamic therapy (aPDT) and antibiotic therapy as an adjunct to conventional non-surgical therapy in patients with aggressive periodontitis. Clinical parameters of probing depth, clinical attachment level and bleeding on probing (BOP) were assessed at baseline, 3, 6, 9 and 12 months after treatment.

Detailed Description
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Background: Treatment of aggressive periodontitis (stage III, grade C periodontitis) represents a big challenge. The aim of the study was to compare the long-term results of antimicrobial photodynamic therapy (aPDT) and antibiotic therapy as an adjunct to conventional non-surgical therapy in patients with aggressive periodontitis. Materials and methods: Twenty subjects with untreated aggressive periodontitis (stage III, grade C periodontitis) were divided into two groups: the test group (TG) received non-surgical therapy and two sessions of aPDT using a laser (HELBO TheraLite laser) with a wavelength of 670nm associated with HELBO Blue photosensitizer, and the control group (CG) received non-surgical therapy and antibiotics (amoxicillin 500mg and metronidazole 400mg, 7 days). Clinical parameters of probing depth, clinical attachment level and bleeding on probing (BOP) were assessed at baseline, 3, 6, 9 and 12 months after treatment.

Official Title
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Antimicrobial Photodynamic Therapy in Treatment of Aggressive Periodontitis (Stage III, Grade C Periodontitis): A Comparison Between Photodynamic Therapy and Antibiotic Therapy as an Adjunct to Non-Surgical Periodontal Treatment

Conditions
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Aggressive Periodontitis

Intervention / Treatment
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* Device: antimicrobial photodynamic therapy
* Drug: systemic antibiotics


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: aggressive periodontitis (stage III, grade C periodontitis) nonsmokers at least 20 teeth in oral cavity systemically healthy Exclusion Criteria: any previous periodontal treatment smoking pregnancy ingestion of systemic antibiotics within three months before therapy

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 38 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: ANTIMICROBIAL PHOTODYNAMIC THERAPY<br>The patients received antimicrobial photodynamic therapy after non-surgical periodontal treatment | Device: antimicrobial photodynamic therapy<br> <br> * Other names: HELBO TheraLite Laser;|
| Experimental: SYSTEMIC ANTIBIOTICS<br>The patients received systemic antibiotics after non-surgical periodontal treatment | Drug: systemic antibiotics<br> <br> * Other names: Metronidazole (Efloran);|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Probing depth reduction | Change in probing depth | 3 months | 
| Bleeding on probing | Bleeding after measurement of probing depth | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical attachment loss | Change in clinical attachment | 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Photodynamic therapy, Antibiotic therapy