A Multi-Center Data System and Collaborative Network in China for Severe Infection and Sepsis Children

Study Overview
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Brief Summary
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1. To research the current situation of severe infection in children in China, and to investigate the incidence, prognosis and disease burden of severe infection in children in different regions of China. 2. Establish the risk prediction model and diagnosi model of severe infection in children, and verify the accuracy of the model in multi-center; 3. To study the effectiveness and safety of different treatments in real diagnosis and treatment, and to evaluate the efficacy of subgroups under different ages and high risk factors.

Detailed Description
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1.Children between 0 and 18 years old. 2.Severe pneumonia and/or sepsis.Patients were included who meet the guidline for diagnosis and treatment of community-acquired pneumonia in Children (2019) issued by the National Health Commission of the people's Republic of China and/or who meet the International Guide to the 2020 campaign to Save sepsis: management of septic shock and sepsis-related organ dysfunction in children. 3.notifiable infectious diseases.4.The researcher believes that he is not suitable to participate in other situations in this study.5.Participants in other clinical trials in the same period.

Official Title
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Establishment of a Multi-Center Big Data System for Severe Infection and a Collaborative Network on Sepsis in Chinese Children

Conditions
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Critical Illness, Severe Sepsis

Intervention / Treatment
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* Other: Not applicable（Cohort study）


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Children between 0 and 18 years old. Severe pneumonia and/or sepsis. Exclusion Criteria: notifiable infectious diseases. The researcher believes that he is not suitable to participate in other situations in this study. Participants in other clinical trials in the same period.

Ages Eligible for Study
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Minimum Age: 29 Days
Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Severe infection<br>Children with severe infection in PICU | Other: Not applicable（Cohort study）<br>* This is a prospective observational study and does not include interventions.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| survival rate | The survival rate of children in 28 days after their discharged from PICU | within 28 days after they discharged from PICU | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| length of stay in PICU | Time from PICU admission to discharge | within 28 days after they discharged from PICU | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Sepsis, Critical Illness, severe infection