Cardiorespiratory Response During Whole Body Vibration Training in Patients With Chronic Lung Disease

Study Overview
=================
Brief Summary
-----------------
Whole body vibration training seems to be a useful adjunct in exercise training in patients with severe COPD. The basic principle relies on reflectory muscle contractions caused by a vibration stimulus. Until now the impact of whole body vibration training on cardiopulmonary parameters remained unknown. Therefore aim of this study is to investigate cardiopulmonary parameters during whole body vibration training in patients with chronic lung disease.

Official Title
-----------------
Cardiorespiratory Response During Whole Body Vibration Training in Patients With Chronic Obstructive Pulmonary Disease (COPD) or Interstitial Lung Disease (ILD)

Conditions
-----------------
Chronic Obstructive Lung Disease (n=10), Interstitial Lung Disease (n=10)

Intervention / Treatment
-----------------
* Other: Whole body vibration


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: COPD stage III or IV according to the Global Initiative for chronic obstructive lung disease [GOLD]) Interstitial Lung disease (forced vital capacity (FVC) < 70% pred., diffusion capacity of lung for carbon monoxide (DLCO) 30-70% pred.) Exclusion Criteria: Oxygen therapy during exercise required Severe exacerbation of lung disease, with necessity of change in medication or persistent symptoms > 3days activated arthrosis /arthropathy/ rheumatoid Arthritis/ acute discopathy acute thrombosis acute musculoskeletal inflammation Epilepsy Gallstones

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Whole body vibration in COPD<br>Patients with COPD GOLD III or IV | Other: Whole body vibration<br> <br> |
| Other: Whole body vibration in ILD<br>PAtients with interstitial lung disease | Other: Whole body vibration<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| peak oxygen consumption (VO2 peak) | subjects perform several short bouts (1 to 3 minutes duration) of squatting exercise with or without whole body vibration. The peak values of each single part is used for comparison. | during 1 exercise session | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| heart rate (HR) | subjects perform several short bouts (1 to 3 minutes duration) of squatting exercise with or without whole body vibration. The peak values of each single part is used for comparison. | during 1 exercise session | 
| minute ventilation (VE) | subjects perform several short bouts (1 to 3 minutes duration) of squatting exercise with or without whole body vibration. The peak values of each single part is used for comparison. | during 1 exercise session | 
| perceived exertion for dyspnea and leg fatigue (Borg-scale) | subjects perform several short bouts (1 to 3 minutes duration) of squatting exercise with or without whole body vibration. The peak values of each single part is used for comparison. | during 1 exercise session | 
| Alveolar-arterial oxygen difference (AaDO2) | subjects perform several short bouts (1 to 3 minutes duration) of squatting exercise with or without whole body vibration. The peak values of each single part is used for comparison. | during 1 exercise session | 
| breathing frequency (BF) | subjects perform several short bouts (1 to 3 minutes duration) of squatting exercise with or without whole body vibration. The peak values of each single part is used for comparison. | during 1 exercise session | 
| peak carbon-dioxide consumption (VCO2 peak) | subjects perform several short bouts (1 to 3 minutes duration) of squatting exercise with or without whole body vibration. The peak values of each single part is used for comparison. | during 1 exercise session | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Whole body vibration, cardiorespiratory response