The Validation and Development of Termination-of-Resuscitation (TOR) Rules in OHCA Patients in Asia Countries

Study Overview
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Brief Summary
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Objectives/Hypotheses Prehospital termination-of-resuscitation (TOR) rules were developed in North American and European sites. Whether they remained valid in different geographic, ethnic, and cultural background areas is still under debate. Differences in characteristics of out-of-hospital cardiac arrests (OHCAs) and configurations of emergency medical service (EMS) between the Western and Asian countries, including relatively lower rate of presenting shockable rhythm (i.e. ventricular fibrillation / ventricular tachycardia; VF/VT), lower rates of bystander CPR, less advanced life support (ALS) implementation, and less public access defibrillators, might create potential threats to the prediction accuracy of TOR rules. We aim to conduct a study to validate the performance of ever published TOR rules in Asian OHCA population, including non-traumatic, traumatic, and pediatric OHCA patients. Furthermore, assess the possible variables that may impact the performance of TOR rules. We also aim to develop new TOR rules based on PAROS registry for Asia population, focusing on non-traumatic, traumatic, and pediatric OHCA patients, respectively.

Official Title
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The Validation and Development of Termination-of-Resuscitation (TOR) Rules in Patients Following Out-of-Hospital Cardiac Arrest (OHCA) in Asia Countries

Conditions
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Out-Of-Hospital Cardiac Arrest

Intervention / Treatment
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* Other: termination of resuscitation rules


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: out of hospital cardiac arrest (OHCA) patients Exclusion Criteria: age <18 years non-EMS transport to the emergency department obvious signs of death (e.g. decapitation, rigor mortis, lividity, and decapitation) or having do-not-resuscitate (DNR) orders missing data despite meeting the inclusion criteria.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| out of hospital cardiac arrest patients in Asia countries<br> | Other: termination of resuscitation rules<br>* Use retrospective data to analyze the accuracy termination of resuscitation rules and further develope a termination of resuscitation rule.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| survival to hospital discharge | survival to 30-day hospitalisation | survival to 30-day hospitalisation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cerebral Performance Categories Scale (CPC) | CPC Scale 1 5, minimum value: 1; maximum value:5; lower score means greater outcome | CPC within 30-day hospitalisation | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Out-Of-Hospital Cardiac Arrest, OHCA