Comparison of Two Calorie Restricted MediterrAsian Diet on Weight Loss in FTO rs9939609 Overweight Carriers

Study Overview
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Brief Summary
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Background: Obesity treatment should be individualized since some calorie restricted diet doesn't work for some individuals. Objective: we assess the effect of two different calorie restriction with MediterrAsian diet on weight loss of FTO rs9939609 carriers with overweight. Methods: we recruit 80 healthy overweight participants aged 20-45 years that randomly allocated in two interventional group [group 1: Mediterrasian diet according to adjusted ideal body weight with 500 calories restriction (RD) and group 2: without 500 calories restriction (NRD)+ Moderate physical activity]. Anthropometric indices will be assesses for all participants weekly for two month. The criteria for weight loss is 250-500 grams weekly. Metabolic indices, physical activity and psychologic aspects will be assesses at baseline and the end of the intervention. Dietary adherence will be checked by 24hr recalls at day 0, 30 and 60. At the end of the study, we compare carriers with different alleles (AA+TA and TT) in two intervention groups to find out which calorie restriction is appropriate for each genotype. Significant p-value is less than 0.05.

Detailed Description
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no data yet

Official Title
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Comparison of the Effect of MediterrAsian Diet With Two Different Calorie Restriction on Anthropometric Indices in Carriers of FTO rs9939609 Polymorphism With Overweigh: Toward Personalized Nutrition

Conditions
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Obesity, Dietary Modification

Intervention / Treatment
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* Behavioral: MediterrAsian diet


Participation Criteria
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Eligibility Criteria
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Minimum age: 20 years Maximum age: 45 years Gender: Both Accepts Healthy Volunteers?: Yes Criteria: Inclusion Criteria: BMI range: 24.9-29.9 (overweight) Ethnicity: Persian Exclusion Criteria: History of any metabolic diseases like Diabetes, CVD, Thyroid problems and ... . History of depression Pregnancy, trying to become pregnant or breast feeding Smoking Use of alcohol Significant weight loos during last two months (>5 kilograms) being on a diet during last two months Use of any drug or supplement

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: restricted diet<br>Mediterrasian diet according to adjusted ideal body weight with 500 calorie restriction | Behavioral: MediterrAsian diet<br>* no other description<br>|
| Experimental: Non restricted diet<br>Mediterrasian diet according to adjusted ideal body weight without 500 calorie restriction | Behavioral: MediterrAsian diet<br>* no other description<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| weight loss |  | 2 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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overweight, Caloric Restriction