Prenatal Diagnosis of the Fetal Esophageal or Intestinal Atresia

Study Overview
=================
Brief Summary
-----------------
Aim- to investigate how prenatal diagnosis of fetal esophageal or intestinal atresia impacts obstetric and neonatal outcomes. Methods- This was a retrospective cohort study at a single center. The study population comprised 51 consecutive pregnancies, including 29 mothers (57%) and their fetuses affected by prenatally diagnosed fetal esophageal or intestinal atresia, and 22 mothers (43%) and their babies with postnatally diagnosed fetal esophageal or intestinal atresia.

Detailed Description
-----------------
Aim- to investigate how prenatal diagnosis of fetal esophageal or intestinal atresia impacts obstetric and neonatal outcomes. Methods- This was a retrospective cohort study at a single center. The study population comprised 51 consecutive participants, including 29 mothers (57%) and their fetuses affected by prenatally diagnosed fetal esophageal or intestinal atresia, and 22 mothers (43%) and their babies with postnatally diagnosed fetal esophageal or intestinal atresia.

Official Title
-----------------
Top Benefits of the Prenatal Diagnosis of the Fetal Esophageal or Intestinal Atresia

Conditions
-----------------
Antenatal Management of the Fetal Gastrointestinal Atresia

Intervention / Treatment
-----------------
* Procedure: scheduled delivery at a tertiary center


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: all pregnancies affected by fetal esophageal, duodenal or intestinal atresia referred to our prenatal diagnosis unit all newborns managed for such atresia in our unit of pediatric surgery Exclusion Criteria: termination of pregnancy, stillbirth, the false positive cases

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| prenatal<br>patients affected by confirmed fetal esophageal, duodenal or intestinal atresia and followed in our high-risk pregnancy unit, and scheduled for delivery between 38 and 39 weeks in our tertiary center, regardless of the patient's place of residence | Procedure: scheduled delivery at a tertiary center<br>* Neonatal units in French hospitals are classified in three levels. The intention is for infants requiring high level care to receive it in a tertiary neonatal unit within the same network when appropriate. In case of known fetal gastro-intestinal artesia, the prenatal care includes obstetric consultation and level 3 ultrasound scheduled every four weeks at our unit until the end of the pregnancy, antenatal consultations with a specialized multidisciplinary team, and an antenatal visit of the birth center to reduce the parental anxiety.<br>|
| postnatal<br>patients with unsuspected fetal atresia who delivered in their local hospitals: their newborns were transferred to our tertiary hospital within 24 hours and the mother had the option to be also transferred in order to follow her baby. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| gestational age of delivery | weeks | 1 year | 
| mode of delivery | Vaginal, Operative vaginal, Elective cesarean section, Cesarean section for fetal indication | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| neonatal morbidity | Age at surgery, Cutaneous stoma, Anastomotic leakage, Mechanical ventilation, Phototherapy, Infection | 1 year | 
| length of hospital stay | Length of neonatal intensive care unit stay, Length of neonatal reanimation stay (days) | 1 year |