Altered Structural-functional Connectivity Coupling on Chronic Subcortical Stroke

Study Overview
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Brief Summary
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The current study aims to reveal the SC-FC coupling pattern and its relationship with motor function in post-stroke survivors with motor dysfunction by multimodal MRI.

Detailed Description
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Stroke is the leading cause of death and disability in China. Recently, many previous studies suggested exploring the functional reorganization of the motor function among post-stroke survivors is urgent to be solved in both clinical work and applied basic research. Investigating the structural connectivity (SC) of the brain could visualize the anatomical connections between different brain regions and exploring the functional connectivity (FC) could reveal the functional activity patterns of the human brain in resting- and task- states. Previous studies suggested that SC-FC coupling analysis may shed light on exploring biological markers for the assessment and treatment of motor deficits in post-stroke survivors. The current study aims to reveal the SC-FC coupling pattern and its relationship with motor function in post-stroke survivors with motor dysfunction by multimodal MRI.

Official Title
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Altered Structural-functional Connectivity Coupling on Chronic Subcortical Stroke: a Resting-state fMRI Study

Conditions
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Stroke, Motor Activity

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Comply with the diagnostic criteria of Stroke in the 2010 Guidelines for the Prevention and Treatment of Cerebrovascular Diseases in China, and confirmed by head CT or MRI. First onset unilateral subcortical stroke (basal ganglia, thalamus, internal capsule, corona radiata, lateral ventricles, etc.). Age ranged from 30 to 75 years old. Right-handedness before stroke. Greater than three months since stroke onset and Brunnstrom graded as III-VI; 6. The condition and vital signs are stable. 7. Sign the informed consent form. Exclusion Criteria: Any contraindications for the MRI examination. History of other brain diseases and drug dependency. Unstable conditions or accompanied by malignant and rapidly progressing diseases, such as severe atrial fibrillation. Serious communication barriers, cognitive impairment, or cooperation with difficulties.

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Stroke group<br>Chronic subcortical stroke participants with motor dysfunction | |
| Healthy controls group<br>Well-matched healthy controls | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Structural-functional Connectivity Coupling | The coupling between structural connectivity and functional connectivity | Within 1 week after enrollment | 
| Fugl-Meyer Assessment | Assessing the motor function in post-stroke participants | Within 1 week after enrollment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Chinese version of Modified Barthel Index | Assessing the activities of daily living in post-stroke participants | Within 1 week after enrollment | 
| Broetz Hand Test | Assessing the hemiplegic hand performance in post-stroke participants | Within 1 week after enrollment | 
| Placebo Questionnaire | Self-evaluation of rehabilitation treatment in post-stroke participants | Within 1 week after enrollment | 
| Hamilton Depression Rating Scale | Assessing the depression in post-stroke participants | Within 1 week after enrollment | 
| Chinese (Putonghua) Version of Oxford Cognitive Screen | Assessing the cognition in post-stroke participants | Within 1 week after enrollment | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Stroke, Motor dysfunction, MRI, structural connectivity, functional connectivity