Rapid Strep Test Results

Study Overview
=================
Brief Summary
-----------------
This is a prospective study seeks to determine how often a rapid antigens test for group A streptococcus is positive in healthy adults

Detailed Description
-----------------
The Unites States recommends the use of rapid antigen tests, but a number of other countries do not, citing a high prevalence of streptococcal carriers and only moderate sensitivity of rapid antigen tests [1]. Indeed, to fully understand when rapid antigen tests should be used, we need to know the streptococcal carrier rate for adults in the United States. Although there is a fair amount of data in this regard for children [2,3], the only study to report this value for adults was from over 20 years ago and was from Sweden [4]. That studied reported a Group A Streptococcus (GAS) carrier rate of 2.4-3.7% in healthy adults. Given how many patients seek medical care for sore throats that may potentially be streptococcal pharyngitis, the investigators believe more data about the GAS carrier rate and the rate of false positive rapid antigen tests is necessary. Thus, the investigators propose a prospective study to evaluate the rate of positive rapid antigen tests in healthy adult patients in our community. The investigators will perform rapid antigen tests for GAS on healthy adult subjects without any symptoms. Consenting patients will fill out a brief data collection form about their medical history, and an investigator will perform a rapid antigen throat swab to assess for GAS. The results of the rapid antigen test will be recorded, and a logistic regression analysis will be performed to determine if certain factors within the subject's medical history are predictive of positive rapid strep tests.

Official Title
-----------------
Rapid Antigen Test Results for Group A Streptococcus in Healthy Adults

Conditions
-----------------
Strept Throat

Intervention / Treatment
-----------------
* Diagnostic Test: Rapid Antigen Test for Group A Streptococcus


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Any person at least 18 years old Exclusion Criteria: pregnant prisoners currently taking antibiotics any acute symptoms

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Healthy Adult Subjects<br> | Diagnostic Test: Rapid Antigen Test for Group A Streptococcus<br>* Rapid strep tests will be performed by throat swab of healthy adult volunteers.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| % Positive Rapid Antigen Strep Tests | % of positive rapid antigen strep tests amongst all volunteers | The throat will be swabbed, and the swab will be immediately analyzed. The results are available after five minutes. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Predictors of Positive Strep Tests | Logistic regression analysis will assess if any of the following are significant predictors of positive strep tests: age, gender, race/ethnicity, chronic medical problems, whether or not the patient has had antibiotics within last month, whether or not they have a history of strep throat, and whether or not they are a medical student or healthcare professional. | After enrollment of all subjects, a logistic regression analysis will be performed. | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Carrier rate, Rapid antigen test