European Transfusion Practice and Outcome Study

Study Overview
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Brief Summary
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The aim of the ETPOS study is to describe differences in transfusion habits throughout Europe and to correlate these habits to perioperative outcome parameters. Special focus is put on the number of PRBCs (packed red blood cells) transfused and the ratio of PRBCs to other blood products or coagulation factors in the operating room. Furthermore the motivation of physicians to transfuse PRBC and blood products in the operating room will be investigated.

Detailed Description
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In European patients undergoing elective non-cardiac surgery receiving at least one PRBC(packed red blood cells) during their surgery it is proposed to: Evaluate evidence of differences in the standard of peri-operative transfusion care in different healthcare systems within Europe, and the use of blood conserving techniques. Evaluate the ratio of transfusion of PRBC to blood products in the operating room Evaluate which factors determine transfusion of PRBC (is it patient's haemodynamics / haemoglobin threshold/ pressure from the surgeon / acute brisk bleeding / else) and blood products (ratio to PRBC / POC (point of care) monitoring/ per protocol/ else) in the operating room Evaluate whether there are factors in transfusion therapy that are associated with outcome (in-hospital mortality and unplanned admission to ICU(Intensive Care Unit).)

Official Title
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European Transfusion Practice and Outcome Study A Multi-central Evaluation of Standard of Transfusion Care and Clinical Outcome for Elective Surgical Patients. Observational Study.

Conditions
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Surgery, Erythrocyte Transfusion, Habits, Anemia, Blood Coagulation Disorders

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: - patients undergoing elective non-cardiac surgery commencing during the three-month period and who received at least one erythrocyte concentrate during their intra-operative stay. Exclusion Criteria: Age < 18 years cardiothoracic surgery emergency trauma patients

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Amount of PRBC and blood products and coagulation factors transfused | Amount of packed red blood cells and blood products and coagulation factors: fresh frozen plasmas (FFPs), platelets (PTs) and tranexamic acid transfused | The Time point at which outcome measure is assessed is during surgery at Day 0 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Factors determining transfusion of PRBC and blood products in different regions of Europe | Reasons for transfusion of PRBC(packed red blood cells)and blood products in different regions of Europe | The Time point at which outcome measure is assessed is during surgery at Day 0 | 
| 30-day mortality | Assesses on Day 30 whether patient is still alive or has died between day zero (Surgery) day 30 after surgery | The Time point at which outcome measure is assessed is at Day 30 after Surgery | 
| Unplanned admission to the ICU | Assesses on day 30 whether the patient had a Unplanned admission to the Intensive care unit(ICU) following surgery (day 0) until the day 30 | The Time point at which outcome measure is assessed is at Day 30 after Surgery | 
| Type and frequency of usage of blood conserving techniques |  | The Time point at which outcome measure is assessed is at Day 0, on Surgery Day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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transfusion, packed red blood cells (PRBC), Transfusion Practice, Transfusion habits, Outcome, elective surgery, ETPOS, ESA, European Society of Anaesthesiology