Sleep-related Breathing Disorders in Cardiological Outpatients

Study Overview
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Brief Summary
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The purpose of this study is to determine the prevalence of sleep-related breathing disorders (SRBD) in clinically stable cardiologic outpatients of a German university clinic by means of polygraphy. Furthermore, the practicability of the underlying diagnostic process in clinical application is assessed as well as the sensitivity and specificity of polygraphy as compared to the reference standard of polysomnography. Another aim is to determine the individual cardiovascular risk profile by pulse wave analysis and risk classification according to European Society of Hypertension (ESH) and European Society of Cardiology (ESC), ESH/ESC risk.

Official Title
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Sleep-related Breathing Disorders in Cardiological Outpatients From a German University Clinic - Prevalence, Classification, Diagnostic Accuracy

Conditions
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Sleep Apnea Syndromes

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age ≥18 years Present chronic cardiovascular disease (incl. but not limited to: ischemic heart disease, arterial hypertension, heart failure, atrial fibrillation) Current clinically stable state (incl. patients after a cardiovascular-related, emergency hospital admission and subsequent recompensation towards the end of their hospital stay Exclusion Criteria: Age <18 years Acute life-threatening disease (incl. but not limited to:instable angina pectoris, acute bronchial asthma, heart failure New York Heart Association (NYHA) stage IV, myocardial infarction, exacerbated chronic obstructive pulmonary disease (COPD), Malignant disease requiring treatment) Pregnancy and/or lactation Any medical, psychological or other condition impairing the patient's ability to provide informed consent

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prevalence of sleep-related breathing disorders | Prevalence of sleep-related breathing disorders as measured by ambulatory polygraphy and defined as an respiratory disturbance index of >=15/h | Once within two days of inclusion | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patients included | Total number of patients included in the study after overall study conclusion | through study completion, an average of 21 months | 
| Number of patients with actually performed polygraphy | Total number of patients in whom ambulatory polygraphy was actually performed, after overall study conclusion | through study completion, an average of 21 months | 
| Number of patients with assessable polygraphy | Total number of patients in whom ambulatory polygraphy was assessable, after overall study conclusion | through study completion, an average of 21 months | 
| Number of patients with actually performed polysomnography | Total number of patients in whom stationary polysomnography was actually performed, after overall study conclusion | through study completion, an average of 21 months | 
| Number of patients with assessable polysomnography | Total number of patients in whom stationary polysomnography was assessable, after overall study conclusion | through study completion, an average of 21 months |