Immuno-epidemiological and Socio-behavioral Evaluation of Release of Sterile Male Aedes Albopictus Mosquitoes on Human-vector Contacts

Study Overview
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Brief Summary
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This trial is based on 2 complementary components, named ExpAlbo Biomarker and CAPAlbo Questionnaire ExpAlbo Biomarker (Exposure to the Aedes albopictus mosquito): This component concerns the epidemiological evaluation of the effectiveness of the release of sterile male mosquitoes on the level of exposure of individuals to the bites of the tiger mosquito through the use of a new immunological biomarker of the human-vector contact, developed over the past 20 years by the IRD-MIVEGEC team. Indeed, when a person is bitten by a mosquito, he or she develops a defence reaction, called an immune reaction, against the mosquito's saliva. The main objective of this study is to measure this immune response, and more specifically the antibody response specifically directed against compounds (peptide = small fragment of a protein) in mosquito saliva, and to determine whether this anti-saliva antibody response, and therefore exposure to mosquito bites, decreases when the mosquito control strategy is applied. CAPAlbo Questionnaire: This component is concerned with assessing the impact of sterile male mosquito releases on perceptions and practices related to exposure to Aedes albopictus based on population-based questionnaire surveys. The main objective of these surveys is to determine whether changes in objective exposure to Aedes albopictus mosquitoes are associated with changes in the perception of the nuisance and in the lifestyle habits of respondents, particularly those related to the prevention of mosquito bites (such as the use of repellents or mosquito nets).

Official Title
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Immuno-epidemiological and Socio-behavioral Evaluation of Release of Sterile Male Aedes Albopictus Mosquitoes on Human-vector Contacts

Conditions
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Mosquito Bite

Intervention / Treatment
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* Other: sterile insect technique (TIS)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: To inhabit on a regular basis in the intervention/control area To speak French

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: A Cluster-Non Randomized Controlled Trial
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: sterile male Aedes albopictus-exposed<br>Sterile male Aedes albopictus are released in the area. | Other: sterile insect technique (TIS)<br>* Sterile male Aedes albopictus mosquitos are released in the area/neighborhood<br>|
| No Intervention: control<br>Sterile male Aedes albopictus are not released in the area. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Immunological indicators | Biomarker based on the measurement of human IgG antibody levels specific to one peptide of Aedes saliva (i.e. Nterm-24kDa salivary peptide) | 6 months | 
| Immunological indicators | Biomarker based on the measurement of human IgG antibody levels specific to one peptide of Aedes saliva (i.e. Nterm-24kDa salivary peptide) | 12 months | 
| Exposure to Aedes mosquito | self-perceived exposure to mosquito will be assessed by questionnaire | 6 months | 
| Exposure to Aedes mosquito | self-perceived exposure to mosquito will be assessed by questionnaire | 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Protective behavior | a composite indicator derived from a questionnaire will rate the protective behavior of the participants to avoid mosquito bites | 6 months | 
| Protective behavior | a composite indicator derived from a questionnaire will rate the protective behavior of the participants to avoid mosquito bites | 12 months |