LINE: Treatment Patterns in postmenopausaL Women With Hormone Receptor Positive Breast Cancer

Study Overview
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Brief Summary
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This is the first study focused on features/stereotypes of the first and second-line treatment patterns in Russia, comparison of different treatments, and determination of effective hormone treatment patterns in real-life practice with evaluation of pharmacoeconomic aspects. Study LINE is designed for collection of data on clinical effectiveness of second-line hormone treatment and quality of life in patients with breast cancer(BC).

Detailed Description
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LINE: Treatment patterns in postmenopausaL women wIth hormone receptor positive breast caNcEr

Official Title
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LINE: Treatment Patterns in postmenopausaL Women With Hormone Receptor Positive Breast Cancer

Conditions
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Local Advanced or Metastatic Postmenopausal Breast Cancer

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Postmenopausal women with hormone receptor-positive breast cancer: Recurrence after the adjuvant hormone therapy; Or initially inoperable locally advanced or metastatic breast cancer progressed after the first line hormone therapy; Ability to read and write and complete questionnaires Provision of written informed consent Patients who have already been prescribed therapy with the above-mentioned lines and who can continue on the prescribed therapy in the investigator's opinion according to his/her regular clinical practice and cure Exclusion Criteria: As per study design, to ensure high validity of data and to obtain accurate information on real-life practice, Patients currently participating in other clinical studies will not be included in this study
Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Collection of data of routine regimens of hormone therapy in postmenopausal women with hormone receptor-positive, locally advanced or metastatic breast cancer |  | 2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quality of life (QoL): the extent of reduction in QoL deficit from 1 visit |  | 2 years | 
| The extent of reduction anxiety inventory |  | 2 years | 
| Effectiveness: Tumor regression; number of patients with complete response (CR), partial response (PR) or stable disease |  | 2 years | 
| Historical data analysis: treatment patterns effectiveness, duration of the adjuvant or first-line hormone treatment |  | 2 years | 
| Response duration |  | 2 years | 
| Performance status (ECOG) |  | 2 years | 
| Co-morbidities and relevant historical data |  | 2 years | 
| The information on spontaneous office visit to oncologist or hospitalization including reasons, diagnosis, days of hospitalization, procedures and concomitant medication changes will be collected. |  | 2 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Breast cancer,, hormone positive,