The Aerobic and Cognitive Training System

Study Overview
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Brief Summary
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This study will determine the effects of simultaneous exercise and cognitive training on cognitive function in healthy older adults. Specifically, this study will compare the use of a tablet-based cognitive training system while exercising with exercise alone, cognitive training alone, and a neutral control condition on cognition.

Official Title
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The Aerobic and Cognitive Training System to Improve Cognition

Conditions
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Healthy Aging

Intervention / Treatment
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* Behavioral: Simultaneous exercise and cognitive training
* Behavioral: Exercise training
* Behavioral: Cognitive Training
* Behavioral: Neutral video


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Generally healthy, age 60-74, and a written statement from their primary care physician indicating that they are able to participate in the 12-week exercise program. Exclusion Criteria: Subjects will be excluded from participating in the study if they express significant concerns about their memory or declines in other cognitive abilities, if they are not English speaking, or if they have histories of significant major neurological, psychiatric, or medical disorder or injury that would affect cognitive function.

Ages Eligible for Study
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Minimum Age: 60 Years
Maximum Age: 74 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Simultaneous exercise and cognitive training<br>Participants in this arm will engage in a 12-week intervention that combines physical exercise and cognitive tablet-based training. This intervention involves use of an exercise bicycle while engaging in cognitive tasks on a tablet computer three times per week. | Behavioral: Simultaneous exercise and cognitive training<br>* Participants in this arm will engage in a 12-week intervention that combines physical exercise and cognitive tablet-based training. This intervention involves use of an exercise bicycle while engaging in cognitive tasks on a tablet computer three times per week.<br>|
| Active Comparator: Exercise training<br>Participants in this arm will engage in a 12-week exercise intervention that involves use of an exercise bicycle three times per week. | Behavioral: Exercise training<br>* Participants in this arm will engage in a 12-week exercise intervention that involves use of an exercise bicycle three times per week.<br>|
| Active Comparator: Cognitive training<br>Participants in this arm will engage in a 12-week intervention that involves cognitive tablet-based training three times per week. | Behavioral: Cognitive Training<br>* Participants in this arm will engage in a 12-week intervention that involves cognitive tablet-based training three times per week.<br>|
| Active Comparator: Neutral Video<br>Participants in this arm will engage in a 12-week intervention that involves watching neutral videos on a tablet computer three times per week. | Behavioral: Neutral video<br>* Participants in this arm will engage in a 12-week intervention that involves watching neutral videos on a tablet computer three times per week.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from baseline in cognitive function during dual-task test at 12 weeks | Performance on serial subtraction during dual-task walking. | Baseline and 12-weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from baseline in stride length during dual-task test | The difference between stride length in single and dual-task walking will be assessed at baseline, 6 weeks, and 12 weeks | Baseline, 6 weeks, 12 weeks | 
| Change from baseline in stride duration during dual-task test | The difference between stride duration in single and dual-task walking will be assessed at baseline, 6 weeks, and 12 weeks | Baseline, 6 weeks, 12 weeks | 
| Change from baseline in stride velocity during dual-task test | The difference between stride velocity in single and dual-task walking will be assessed at baseline, 6 weeks, and 12 weeks | Baseline, 6 weeks, 12 weeks | 
| Change from baseline in stride length variability during dual-task test | The difference between stride length variability (measured by coefficient of variation) in single and dual-task walking will be assessed at baseline, 6 weeks, and 12 weeks | Baseline, 6 weeks, 12 weeks | 
| Change from baseline in stride duration variability during dual-task test | The difference between stride duration variability (measured by coefficient of variation) in single and dual-task walking will be assessed at baseline, 6 weeks, and 12 weeks | Baseline, 6 weeks, 12 weeks | 
| Change from baseline in stride velocity variability during dual-task test | The difference between stride velocity variability (measured by coefficient of variation) in single and dual-task walking will be assessed at baseline, 6 weeks, and 12 weeks | Baseline, 6 weeks, 12 weeks | 
| Change from baseline in cognitive function during dual-task test at 6 weeks | Performance on serial subtraction during dual-task walking. | Baseline and 6-weeks |