Mnemonic Strategy Versus Spaced Retrieval Training in Those With Mild Cognitive Impairment

Study Overview
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Brief Summary
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This study compared two active cognitive interventions to evaluate whether one improved memory more than the other in patients with mild cognitive impairment. Participants were randomized to either memory strategy training or spaced retrieval training and completed memory tests before and after 3 training sessions. Participants returned 1 month after treatment to see how well they remembered the learned information. Brain scans (functional MRI) were collected before and after the interventions to see if training changed the way brain regions were functioning.

Detailed Description
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Individuals with MCI were randomized to 3 sessions of mnemonic strategy or spaced retrieval training that focused on object location associations. Across these training sessions, each group received 9 training trials for each of the 45 trained stimuli. Task-fMRI was acquired before and after training. Memory was again evaluated 1 month after the last training session. The primary outcome measure was memory for the trained stimuli while secondary outcome was accuracy for novel stimuli acquired outside of the MRI environment.

Official Title
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Comparing Mnemonic Strategy With Spaced Retrieval Training in Patients With Mild Cognitive Impairment (B6366-W)

Conditions
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Mild Cognitive Impairment

Intervention / Treatment
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* Behavioral: mnemonic strategy training
* Behavioral: spaced retrieval training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: -Diagnosis of MCI according to Petersen (2004) criteria, right handed Exclusion Criteria: Diagnosis of other neurological condition, active drug/alcohol abuse/dependence, moderate-severe depression or other Axis I diagnoses.
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Randomization to Mnemonic strategy or spaced retrieval training
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Mnemonic strategy training<br>Training using mnemonic strategies | Behavioral: mnemonic strategy training<br>* training using mnemonic strategies<br>|
| Active Comparator: Spaced retrieval training<br>Training using spaced retrieval | Behavioral: spaced retrieval training<br>* training using spaced retrieval<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percent of Correct Object Location Associations Assessed up to 1 Month Post-treatment | Change in memory for 45 trained object location associations | up to 1 month after last training session | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Accuracy (vs. Baseline) on Novel Object Location Associations | Change in accuracy for novel object location associations using a touchscreen task; distance measured in cm from actual location | up to 1 month after last training session | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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MCI, cognitive training, memory training, dementia, Alzheimer's disease