linjc16/ctgov huggingface dataset:
Verification of Endotracheal Tube Placement by Ultrasound in the Obese Patient

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine whether verification of correct tube placement after endotracheal intubation in the obese patient can be conducted as fast with ultrasound as with the conventional method of combined auscultation and capnography. The investigators hypothesize that ultrasound is a faster method for verifying correct endotracheal tube placement in the obese patient than combined auscultation and capnography.

Detailed Description
-----------------
Both verification methods are conducted in all patients and patients act as their own control

Conditions
-----------------
Intubation, Intratracheal, Obesity

Intervention / Treatment
-----------------
* Device: Ultrasound


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Planned for bariatric surgery in general anaesthesia Planned for endotracheal intubation BMI above 30 Exclusion Criteria: Predicted difficult airway in the pre-anaesthesia airway evaluation. Unpredicted difficult airway during induction of anaesthesia where assistance is needed by the investigators.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Obese patients for planned surgery and endotracheal intubation<br> | Device: Ultrasound<br>* Ultrasound scan just proximal to the suprasternal notch during intubation and ultrasound scan of both lungs during ventilation<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Difference in time to correct verification of endotracheal tube placement between ultrasound and combined auscultation and capnography |  | 0 to 1 hour | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Difference in time to correct verification of endotracheal tube placement between ultrasound and auscultation alone |  | 0 to 1 hour | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Intubation, intratracheal, Ultrasonography, Auscultation, Capnography, Obesity
Disease Burden of Pneumonia, Meningitis and Bacteremia Among Children in Japan: Pneumonet Japan

Study Overview
=================
Brief Summary
-----------------
Streptococcus pneumoniae is a major cause of pneumonia, among infants and children in Japan and worldwideThis study plans to investigate the rate of invasive pneumococcal disease IPD  and the rate of hospitalizations due to pneumonia in Okinawa and the Eastern half of Hokkaido Currently, only a limited information about pneumococcal disease burden is available in Japan.

Official Title
-----------------
Epidemiological Surveillance Network Study To Assess the Disease of Pneumonia in Infants and Children in Japan

Conditions
-----------------
Pneumococcal Disease

Participation Criteria
=================
Eligibility Criteria
-----------------
Eligibility Criteria - Children residing in the surveillance area(s) aged 28 days to <60 months with clinical suspicion of pneumonia, meningitis and bacteremia who were admitted to the hospital.

Ages Eligible for Study
-----------------
Minimum Age: 28 Days
Maximum Age: 60 Months

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 1.Describe the distribution of causal pathogen of meningitis and bacteremia 2.Estimate the hospital admission rate of pneumonia patients 3.Estimate the incidence rate of IPD 4.Describe the serotype distribution of S. pneumoniae |  | 2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 1.CFRof patients admitted with IPD and/or pneumonia. 2.Antibiotic resistance rate of S. pneumoniae 3.Risk factor distribution 4.Average duration of the hospitalization of patients with IPD, meningitis, and/or pneumonia. |  | 2-3 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
PNEUMONET JAPAN STUDY
Prediction of Sepsis After Percutaneous Nephrolithotomy

Study Overview
=================
Brief Summary
-----------------
We aim to determine the preoperative predictors of sepsis after percutaneous nephrolithotomy (PCNL) in patients with unilateral, solitary and proximal ureteral stones.

Official Title
-----------------
A Pre-operative Nomogram for Sepsis After Percutaneous Nephrolithotomy Treating Solitary, Unilateral, and Proximal Ureteral Stones

Conditions
-----------------
Percutaneous Nephrolithotomy, Infection, Urolithiasis, Albumin Globulin Ratio

Intervention / Treatment
-----------------
* Procedure: percutaneous nephrolithotomy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: (1) PCNL was performed to treat unilateral, solitary, and proximal ureteral stones; and (2) age ≥18 years Exclusion Criteria: anatomical renal abnormalities (horseshoe kidney, solitary kidney, transplant kidney and kidney duplication)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| proximal ureteral stone patient<br>Patients underwent percutaneous nephrolithotomy treating unilateral, solitary and proximal ureteral stones. | Procedure: percutaneous nephrolithotomy<br>* percutaneous surgery using nephroscope<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| sepsis | the concurrence of infection and a minimum of two of the following within 48 hours of surgery: (1) heart rate >90/minute, (2) body temperature >38°C, (3) leukocyte count <4,000 cells/μL or >12,000 cells/μL, and (4) respiratory rate >20/minute | within 48 hour after surgery |
Effect of Daily Short Message System (SMS) Reminders on Medication Adherence to Oral Antipsychotics in Patients With Schizophrenia

Study Overview
=================
Brief Summary
-----------------
This study is a 6-month, multicenter, randomized study to assess the effect of daily SMS reminders sent during 3 months in the adherence to oral antipsychotic treatment in stabilized outpatients with schizophrenia.

Official Title
-----------------
Effect of Daily SMS Reminders on Medication Adherence to Oral Antipsychotics in Patients With Schizophrenia

Conditions
-----------------
Schizophrenia

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Male or female patients older than 18 years With a diagnosis of schizophrenia (DSM-IV TR criteria) Stabilized out-patients Under oral antipsychotic monotherapy Exclusion Criteria: Administration of a depot antipsychotic drug Suicide risk

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Morisky Green Questionnaire |  | baseline, at months 3 and 6 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical Global Impression- Schizophrenia (CGI-SCH) |  | baseline, at months 3 and 6 | 
| Register of Adherence to Treatment (RAT) |  | baseline, at months 3 and 6 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Schizophrenia, Therapeutic adherence, Short message system, Mobile phone
Nipple-sparing Mastectomy in Combined With Buried Flap Monitoring

Study Overview
=================
Brief Summary
-----------------
Learning curve of ms-Tram and DIEP breast reconstructions surgery are important to guide the training of new surgeon. Buried flap post operative monitoring without implantable doppler was seldom studied, a validated protocol reported. The complication rates of the flap and oncological safety were studied.

Detailed Description
-----------------
Operative time and complication rate are employed to analysis the learning curve of the ms-Tram and DIEP surgery,which is meaningful for the new microsurgeon training. Buried flap without the implatable doppler is very common condition all over the world, and the complication rate was evaluated as evidence of reliable of the validated monitoring protocol. Complication rates were considered as different before and after the platue of the learning curve. Within the study of the learning curve, complication rates were reported.

Official Title
-----------------
The Feasibility of Nipple-sparing Mastectomy in Combined With Abdominal Free Flap Breast Reconstruction Without Skin Paddles for Flap Monitoring: a Single-center Experience

Conditions
-----------------
Breast/Surgery

Intervention / Treatment
-----------------
* Other: No intervention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Female breast cancer patients with age > 18 years Received autologous abdominal free-flap breast reconstruction (including muscle-sparing free TRAM or DIEP) Exclusion Criteria: Breast conserving patient Implant-based breast reconstruction

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: No intervention|No intervention|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Total flap failure rate | The rate of ms-tram and diep flap were removed from the patients | Through study completion， and average of 2.5 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
breast cancer, DIEP, ms-TRAM, breast reconstruction, learning curve, nipple spring mastectomy
Dermacyd Femina (Lactic Acid) Pocket BR - Compatibility

Study Overview
=================
Brief Summary
-----------------
To demonstrate the absence of irritation potential (primary dermic irritability and cumulated dermic irritability) and allergy (sensibilization) of the product Dermacyd Femina (Lactic Acid) Pocket BR.

Official Title
-----------------
Study for Dermatological Evaluation of Topic Compatibility (Primary and Accumulated Dermical Irritability, Dermical Sensitivity) of Dermacyd Femina Pocket BR.

Conditions
-----------------
Hygiene

Intervention / Treatment
-----------------
* Drug: Lactic Acid


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: Age between 18 and 60 years old; Phototype Skin I,II, III e IV Integral skin test in the region; Willingness in following the study procedures and to be present in the clinic at the days and scheduled time for medical evaluations and for application of occlusion; Exclusion criteria: Lactation or gestation Use of Antiinflammatory and/or immunosuppression drugs one month before the study; Personnel history of atopy; History of sensitivity or irritation for topic products; Active cutaneous disease; Use of new drugs or cosmetics during the study; The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>Lactic Acid (Dermacyd Femina) | Drug: Lactic Acid<br>* Lactic Acid (Dermacyd Femina)<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The absence of primary and accumulated dermical irritability and dermical sensitivity will be evaluated using International Contact Dermatitis Research Group (ICDRG) scale. |  | Throughout the study |
Efficacy of Retinal Nerve Fiber Layer (RNFL) / Retinal Thickness Ratio by Cirrus OCT Utilizing Spectral -Domain Technology as a Diagnostic Predictor of Glaucoma

Study Overview
=================
Brief Summary
-----------------
Glaucoma is presumed to be an axonal disease which starts at the lamina cribrosa. This assumption has led to the monitoring of the retinal nerve fiber layer thickness for the diagnosis and monitoring of progression of glaucoma. However, varying disc size, myopia and tilted discs affect the thickness of the retinal nerve fiber layer. This study aims to ascertain the ration of the retinal nerve fiber layer against full retina as a predictor of glaucoma diagnosis and progression.

Official Title
-----------------
Efficacy of RNFL / Retinal Thickness Ratio by Cirrus OCT Utilizing Spectral -Domain Technology as a Diagnostic Predictor of Glaucoma

Conditions
-----------------
Glaucoma, Myopia

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Primary open angle glaucoma Myopia Myopia with evidence of glaucoma Normal controls Exclusion Criteria: Evidence of retinal disease BCVA < 0.4 Secondary glaucoma due to intraocular inflammation Lens induced glaucoma Tumor induced glaucoma Neovascular glaucoma

Ages Eligible for Study
-----------------
Minimum Age: 10 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>Primary open angle glaucoma | |
| 2<br>Normal Control | |
| 3<br>Myopia with no evidence of glaucoma | |
| 4<br>Myopia with evidence og glaucoma | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ratio of RNFL / Full thickness retina |  | 2 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
glaucoma, myopia, myopia with glaucoma, normal control
Influence of Bag Volume Variation on the Reproducibility of Inert Gas Rebreathing

Study Overview
=================
Brief Summary
-----------------
Non-invasive inert gas rebreathing (IGR) based on the Fick Principle showed promising results in the determination of pulmonary blood flow (PBF). The volume of the rebreathing bag (Vbag) is proposed by the system, however, elderly patients or those suffering from high grade pulmonary diseases might be unable to entirely rebreathe this volume and therefore fail to completely mix the test gases. The aim of our study is to evaluate the effect of adapting Vbag on the reproducibility of IGR measurements in patients with obstruction (group A), restriction (group B) and pulmonary healthy controls (group C).

Official Title
-----------------
Influence of Bag Volume Variation in Inert Gas Rebreathing Pulmonary Blood Flow Measurements on the Reproducibility in Patients With Pulmonary Diseases

Conditions
-----------------
Chronic Obstructive Pulmonary Disease, Bronchial Asthma, Restrictive Pulmonary Disease

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: ability to perform rebreathing maneuver Exclusion Criteria:

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Obstruction<br>Patients suffering from pulmonary obstruction | |
| Restriction<br>Patients suffering from pulmonary restriction | |
| Controls<br>Pulmonary healthy controls | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| pulmonary blood flow | variation of serial pulmonary blood flow measurements | 1 day |
Ocular Blood Flow in Colorectal Cancer Patients

Study Overview
=================
Brief Summary
-----------------
In colorectal cancer therapy anti-angiogenic strategies have become a cornerstone of treatment regimens in the metastatic setting. Addition of bevacizumab to conventional chemotherapeutic combination regimens has improved the median overall survival of advanced colorectal cancer patients by approximately 5 months. Selecting patients, who will benefit from anti-angiogenic approaches, would be highly desirable in order to optimize treatment strategies. Changes in ocular blood flow may be an attractive biomarker for predicting treatment response. In light of the given alternative first line treatment options such a predictive biomarker would be of clinical benefit. In the proposed study the investigators will assess potential changes in the ocular blood flow of mCRC patients after treatment with standard of care anti-angiogenic/cytotoxic therapy as an early predictive marker of treatment response as assessed by standard CT-scan

Official Title
-----------------
Exploratory Study Investigating Ocular Blood Flow in Colorectal Cancer Patients Before and After Treatment With Anti-angiogenic Therapy

Conditions
-----------------
Metastatic Colorectal Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Male or female patients (age 18 and over) suffering from mCRC. Normal findings in ophthalmic examination (except the investigator finds an abnormality irrelevant for the purpose of the study.) Patients, which are scheduled for standard of care treatment with chemotherapy plus bevacizumab Exclusion Criteria: Refusal to give informed consent Severe hypertension (RR ≥180/110) Epilepsy Pregnancy and breastfeeding women

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 99 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between ocular blood flow (retinal blood flow) and treatment response | mean RBCs velocity in Hz and blood flow in arbitrary units will be reported and correlated with response rates (CR,PR,SD or PD) | Within 2-3 months at restaging | 
| Correlation between retinal vessel diameter and treatment response | Retinal vessel diameter will be reported and correlated with response rates (CR,PR,SD or PD) | Within 2-3 months at restaging | 
| Changes in retinal surface before and after therapy as measured by optical coherence tomography |  | Within 2-3 months at restaging |
Painless Subconjunctival Antibiotic and Antifungal Injection in Corneal Ulcer Patients

Study Overview
=================
Brief Summary
-----------------
The propose of this study is to determine the efficacy of 2% xylocaine in reducing pain due to subconjunctival antibiotic and antifungal injection.

Official Title
-----------------
Painless Subconjunctival Antibiotic and Antifungal Injection in Corneal Ulcer Patients.

Conditions
-----------------
Corneal Ulcer

Intervention / Treatment
-----------------
* Procedure: Lidocaine/NSS
* Procedure: NSS/Lidocaine


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: The corneal ulcer patients who are diagnosed by ophthalmologist and have 2 of 3 in these following features. corneal epithelial defect with stromal infiltration reaction in anterior chamber positive for bacteria or fungus The patients have to receive subconjunctival antibiotic injection twice at least. The patients must be informed consent. Exclusion Criteria: The patients who have history of allergy of local anesthetics, antibiotics or antifungal drugs. The patients who administered NSAIDs or weak opioids within 24 hours prior to subconjunctival antibiotic/antifungal injection. Unable to cooperate with the treatment. Pregnant women

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: NSS/Lidocaine<br>First injection: Normal saline Second injection: 2% Lidocaine without adrenaline | Procedure: NSS/Lidocaine<br>* First injection: subconjunctival NSS 0.4 ml. before antibiotic injection Second injection (24 hours later): subconjunctival 2% lidocaine without adrenaline 0.4 ml. before antibiotic injection<br>|
| Experimental: Lidocaine/NSS<br>First injection: 2% Lidocaine without adrenaline Second injection: Normal saline | Procedure: Lidocaine/NSS<br>* First injection: subconjunctival 2% lidocaine without adrenaline 0.4 ml. before antibiotic injection Second injection (24 hours later): subconjunctival NSS 0.4 ml. before antibiotic injection<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Numeric rating scale |  | immediately after injection | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Side effects |  | 24 hours after injection | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
corneal ulcer, painless, subconjunctival injection, antibiotics, antifungal, lidocaine