Assessment of Atrial Cardiomyopathy Using MRI as a Predictor of Cardiac Post-Operative Atrial Fibrillation After Cardiac Surgery.

Study Overview
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Brief Summary
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After cardiac surgery, there is a high prevalence of postoperative atrial fibrillation (POAF). However, its diagnostic and therapeutic management is poorly codified. This pathology is caused by atrial abnormalities which form the concept of atrial cardiomyopathy. New tools affording to itemize the atrial cardiomyopathy are needed. Indeed, current tools, as echocardiography and electrocardiogram are relevant but only lead to a raw evaluation of the atrial cardiomyopathy. MRI, because of the assessment of the atrial fibrosis by late gadolinium assessment (LGE) and 4D flow magnetic resonance imaging (MRI) could be relevant to specify the atrial cardiomyopathy.

Detailed Description
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The aim of the study is to evaluate the atrial cardiomyopathy, assessed by magnetic resonance imaging (MRI), as a predictor of postoperative atrial fibrillation (POAF) after with coronary artery bypass graft surgery .

Official Title
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Assessment of Atrial Cardiomyopathy Using MRI as a Predictor of Cardiac Post-Operative Atrial Fibrillation After Cardiac Surgery.

Conditions
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Coronary Artery Bypass Grafting

Intervention / Treatment
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* Device: cardiac Magnetic Resonance Imaging (MRI)
* Biological: Blood sample
* Procedure: Cardiac muscle biopsy
* Device: Holter-electrocardiogram (ECG)
* Other: medical examination


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age ≥ 18 years Indication for surgical myocardial revascularization by coronary artery bypass Patient affiliated or entitled to a social security scheme Informed consent for participation in the study Exclusion Criteria: Contraindication to cardiac MRI (Severe Kidney disease, Allergy to gadoliniumn, ...) History of Atriale Fibrillation (AF) Indication of cardiac valve surgery concomitantly with Coronary Artery Bypass Grafting (CABG). pregnant or breast-feeding women

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Coronary Artery Bypass Grafting<br>Patient with indication of Coronary Artery Bypass Grafting will be included. They will have: before surgery : cardiac Magnetic Resonance Imaging (MRI), Blood sample during surgery : Cardiac muscle biopsy after surgery : Holter-electrocardiogram (ECG), medical examination | Device: cardiac Magnetic Resonance Imaging (MRI)<br>* Cardiac magnetic resonance imaging (MRI) will be realized before Coronary Artery Bypass Grafting for assess atrial cardiomyopathy.<br>* Other names: 4D flow Magnetic Resonance Imaging with Late Gadolinium Enhancement;Biological: Blood sample<br>* Blood sample will be realized (4 tubes of 4ml blood, 16ml in total) before Coronary Artery Bypass Grafting.<br>Procedure: Cardiac muscle biopsy<br>* Cardiac muscle biopsy will be realized during Coronary Artery Bypass Grafting.<br>Device: Holter-electrocardiogram (ECG)<br>* Holter-electrocardiogram (ECG) will be realized 1 year after Coronary Artery Bypass Graftin during 3 days to diagnose the occurrence of atrial fibrillation.<br>Other: medical examination<br>* medical examination will be realized 1 year after Coronary Artery Bypass Graftin. Theses datas will collected: events during the follow-up year and evaluation of the Holter-electrocardiogram result.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Analysis of the occurrence of Post-Operative Atrial Fibrillation | Measured by a continuous recording of cardiac electrical activity during 7 days after the surgery. | 7 days after the surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Analysis of the occurrence of Atrial Fibrillation | Analysis of the occurrence of Atrial Fibrillation evaluated during the first year post-operatively. | Year: 1 | 
| Anatomopathological parameters for the evaluation of tissue fibrosis | Analysis Anatomopathological parameters for the evaluation of tissue fibrosis evaluated by cardiac muscle biopsy. | Year: 1 | 
| Assessment of Atrial Heart Disease by cardiac Magnetic Resonance Imaging (MRI) results | Assessment of Atrial Heart Disease by cardiac Magnetic Resonance Imaging (MRI) results to find a correlation with Post-Operative Atrial Fibrillation. | Before the surgery | 
| Correlation between biological parameter Interleukin 1 (IL-1) and occurrence of Post-Operative Atrial Fibrillation | Measured by blood sample results. | Years: 2 | 
| Correlation between biological parameter TNF-α and occurrence of Post-Operative Atrial Fibrillation | Measured by blood sample results. | Years: 2 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Post Operative Atrial Fibrillation, magnetic resonance imaging, Coronary Artery Bypass Grafting (CABG)