Hypothalamo-pituitary Adrenal Axis Activity and Neuropsychological Consequences in Type 1 Diabetes in Childhood

Study Overview
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Brief Summary
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The general objective is to precise the role of HPA axis activity in neuropsychological consequences of type 1 diabetes. The investigators hypothesize that hyperactivity of HPA axis is associated with higher scores of depression and changes in hippocampal volume and mean diffusion.

Detailed Description
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Background: Type 1 diabetes could be associated with hyperactivity of hypothalamo-pituitary adrenal (HPA) axis. Type 1 diabetes is associated with higher frequency neuropsychological consequences as mood disorders and structural changes in brain, particularly in hippocampus. Purpose: To describe the association between HPA axis activity and anxiety and depression scores in 6-12 year's old diabetes children. Abstract: The general objective is to precise the role of HPA axis activity in neuropsychological consequences of type 1 diabetes. The investigators hypothesize that hyperactivity of HPA axis is associated with higher scores of depression and changes in hippocampal volume and mean diffusion.

Official Title
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Hypothalamo-pituitary Adrenal Axis Activity: Relation With Neuropsychological Consequences in Type 1 Diabetes in Childhood. The CORTICODIAB Study

Conditions
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Type 1 Diabetes

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diabetic group: diabetes for 1 year 6-12 year's old included in ISIS-DIAB protocol. Control group: brother or sister of a diabetic children 6-12 year's old. Exclusion Criteria: Per os or inhaled corticoid in the previous month of inclusion. Acute infectious disease in the previous week of inclusion. Other chronic disease than diabetes type1. Psychiatric disorders or psychiatric treatment.

Ages Eligible for Study
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Minimum Age: 6 Years
Maximum Age: 12 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Diabetic children<br>physical examination Glucocorticoid sensitivity index DNA sample Anxiety and depression questionnaires depression questionnaire MRI | |
| Controls<br>physical examination Glucocorticoid sensitivity index DNA sample Anxiety and depression questionnaires depression questionnaire MRI Laboratory tests | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mean of nocturnal urinary free cortisol during 5 days. |  | During 5 days after the inclusion | 
| Depression (CDI) score |  | At the inclusion | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mean of awakening salivary cortisol and mean of nocturnal urinary cortisol metabolites during 5 days |  | During 5 days after the inclusion | 
| Profiles of glucocorticoid sensitive genes expressed in peripheral blood mononuclear cells. |  | At the inclusion | 
| Anxiety (STAI) score |  | At the inclusion | 
| Polymorphisms of genes involved in HPA axis activity |  | At the inclusion | 
| Hippocampal volume and mean diffusion |  | At the inclusion |