Dynamic Changes in Some Facial Muscles After Hyaluronic Acid Filler Injection

Study Overview
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Brief Summary
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assess electrophysiological changes in some facial muscle dynamics following hyaluronic acid filler injection in superficial versus deep level of injection.

Detailed Description
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Participants will be subjected to injection of cross-linked hyaluronic acid fillers on both sides of the face in 3 different regions: temples, cheeks and chins. Each female will undergo: Before injection: Aesthetic facial clinical analysis. Baseline quantitative surface electromyography. Baseline digital photography. Injection: Each female will receive the injection in the particular facial region at superficial level to the muscle (subcutaneous) on one side and the same amount at deep level to the muscle (supraperiosteal) on the other side. One week after injection: Follow up quantitative surface electromyography. Follow up digital photography.

Official Title
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Dynamic Changes in Some Facial Muscles After Superficial Versus Deep Hyaluronic Acid Injection: An Electromyographic Study

Conditions
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Changes in Facial Muscles Following Filler Injection

Intervention / Treatment
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* Drug: hyaluronic acid filler injection


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age: 20-60 years. Sex: females. Areas eligible for injection: temples, cheeks and chin. Exclusion Criteria: Active infection near the site of injection. Pregnant or lactating women. Patients suffering from any neuromuscular disorders. Known allergy/hypersensitivity to hyaluronic acid fillers. History of botulinum toxin injection in the last 4 months. History of injection of fillers in the last 2 years. Patients receiving any muscle relaxants. Coagulation disorder or anticoagulants therapy.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: deep injection of hyaluronic acid fillers<br>Each female will receive filler injection deep to the muscle (supraperiosteal) on one side of the face. | Drug: hyaluronic acid filler injection<br>* quantitative surface electromyography before injection(baseline) and one week after injection<br>* Other names: quantitative surface electromyography;|
| Active Comparator: superficial injection of hyaluronic acid fillers<br>Each female will receive filler injection at superficial level to the muscle (subcutaneous) on the contralateral side(same dose and same site). | Drug: hyaluronic acid filler injection<br>* quantitative surface electromyography before injection(baseline) and one week after injection<br>* Other names: quantitative surface electromyography;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| electrophysiological changes in some facial muscles | baseline and follow up quantitative surface electromyography | one week |