Caffein Consumption and Response Inhibition

Study Overview
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Brief Summary
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With the abundance of energy-dense foods that are designed for ease of consumption in the current environment, it is of importance to better understand the factors that may undermine the control of energy intake at healthy levels. One of the factors that is potentially important in response inhibition is caffeine. The aim is to assess the direct effects of caffeine on response inhibition, using a No Go/Go-task. We will also assess whether the presentation of food cues, i.e. as words or as pictures, modulate response inhibition different in restrained vs. non-restrained eaters.

Detailed Description
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In a blinded, randomized cross-over design, participants will receive either a capsule with caffeine or placebo at two separate occasions whereupon study tasks will be performed.

Official Title
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Does Caffeine Consumption Improve Response Inhibition to Food Cues?

Conditions
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Eating Behavior, Obesity

Intervention / Treatment
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* Drug: Caffeine
* Drug: Placebo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Only males 18 ≤ 35 years Healthy (self rated) Used to drink caffeine Used to eat breakfast regularly (≥ 5 times a week). Non-smokers Exclusion Criteria: BMI outside the range of 18,5 ≤ 25 hypersensitivity for the ingredients of the foods under study being a vegan or vegetarian. Participants reported not using products that are artificially sweetened, nor sugar in coffee and/or tea Presence of any chronically disease and/or treatment with medication

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Caffeine<br>Administration of one gelatin capsule containing 200-300 mg of caffeine with subsequent cognitive tasks and food test. | Drug: Caffeine<br>* Administration of one gelatin capsule containing 200-300 mg of caffeine with subsequent cognitive tasks and food test.<br>|
| Placebo Comparator: Placebo<br>Administration of placebo (one gelatin capsule containing starch) with subsequent cognitive tasks and food test. | Drug: Placebo<br>* Administration of placebo with subsequent cognitive tasks and food test.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Inhibition control | Measurement inhibition control via a computer test (NoGo-Go task. | 20 min | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Food test | Measure of participants food intake. | 20 min | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Caffeine effects, Inhibitory control