SU5416 and Paclitaxel in Treating Patients With Advanced Cancer

Study Overview
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Brief Summary
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RATIONALE: Drugs such as SU5416 may stop the growth of cancer by stopping blood flow to the tumor. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining SU5416 with chemotherapy may kill more tumor cells. PURPOSE: Phase I trial to study the effectiveness of combining SU5416 and paclitaxel in treating patients who have advanced cancer.

Detailed Description
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OBJECTIVES: Determine the maximum tolerated dose of SU5416 when combined with paclitaxel in patients with advanced malignancies. Determine the toxicities and pharmacokinetics of this regimen in these patients. Determine the effects of this regimen on a variety of histological and molecular biomarkers of angiogenesis, including in vitro activity assays of endothelial cell proliferation, migration, and invasion. OUTLINE: This is a dose escalation study of SU5416. Patients receive SU5416 IV over 1 hour twice weekly during the first week. During subsequent courses, SU5416 is administered on days 1, 4, 8, 11, 15, 18, 22, and 25. Paclitaxel begins on the second week of therapy and is administered IV over 1 hour on days 1, 8, 15, and 22. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity. Cohorts of 3-6 patients receive escalating doses of SU5416 until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 6 patients experience dose limiting toxicity. PROJECTED ACCRUAL: Approximately 24 patients will be accrued for this study within 12-18 months.

Official Title
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Phase I Trial of SU5416 in Combination With Weekly Paclitaxel in Patients With Advanced Malignancies

Conditions
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Unspecified Adult Solid Tumor, Protocol Specific

Intervention / Treatment
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* Drug: paclitaxel
* Drug: semaxanib


Participation Criteria
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Eligibility Criteria
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DISEASE CHARACTERISTICS: Histologically or cytologically proven advanced malignancy for which no satisfactory treatment exists Must have tumor accessible by biopsy Minimum of 1 baseline biopsy required No brain metastases or primary CNS tumor PATIENT CHARACTERISTICS: Age: 18 and over Performance status: WHO 0-2 Life expectancy: At least 3 months Hematopoietic: Absolute neutrophil count at least 1,500/mm3 Platelet count at least 100,000/mm3 Hepatic: SGOT and SGPT less than 2 times upper limit of normal unless due to presence of tumor Bilirubin normal Renal: Creatinine no greater than 1.5 mg/dL Creatinine clearance greater than 60 mL/min Cardiovascular: No uncompensated coronary artery disease by ECG or physical examination No myocardial infarction or severe unstable/angina within the past 6 months No severe peripheral vascular disease associated with diabetes mellitus No severe deep vein or arterial thrombosis within the past 3 months Pulmonary: No pulmonary embolism within the past 3 months Other: Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception No unstable or severe concurrent medical condition No active uncontrolled infection No history of allergic reaction to paclitaxel or Cremophor No greater than grade 1 peripheral neuropathy PRIOR CONCURRENT THERAPY: Biologic therapy: No prior SU5416 Chemotherapy: No prior paclitaxel Greater than 4 weeks since prior chemotherapy (6 weeks for nitrosourea or mitomycin) and recovered Endocrine therapy: Not specified Radiotherapy: Greater than 4 weeks since prior radiotherapy and recovered Surgery: See Disease Characteristics Other: Recovered from any prior investigational agents No other concurrent investigational agents

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: paclitaxel|nan|
|Drug: semaxanib|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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unspecified adult solid tumor, protocol specific