PRV-based Detection of CAD in Comparison to Standard Methods

Study Overview
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Brief Summary
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This is a validation study comparing a pulse wave based algorithm for the detection of coronary artery disease with parameters from coronary angiography, echocardiography and cardiogoniometry.

Detailed Description
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The study will validate a pulse wave based algorithm for the detection of coronary artery disease (CAD) with parameters from standard methods. Subjects will be patients admitted to coronary angiography due to suspected CAD. Pulse wave signals will be analyzed according to novelly established algorithm regarding the presence of CAD and/or myocardial ischemia. These results be compared to the diagnoses made by coronary angiography (primary endpoint): presence of minimum one coronary artery stenose >=50%. For secondary analyses, results will be compared to parameters form echocardiography and cardiogoniometry.

Official Title
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Comparison of a Pulse Wave Based Approach for Detection of Coronary Artery Disease Compared to Standard Methods

Conditions
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Coronary Artery Disease

Intervention / Treatment
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* Other: Diagnostic algorithm


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Coronary angiography indication present informed written consent Exclusion Criteria: Previous coronary angiography Known CAD (history of coronary angioplasty, stent implantation and/or bypass surgery) atrial fibrillation (at time of measurement) severe ventricular extrasystole (e.g. >=10% ventricular extrasystoles, bigemina) pregnancy, lactation

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 100 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Diagnostic algorithm|Validation of a diagnostic algorithm used to detect coronary artery disease and/or myocardial ischemia based on pulse wave analyses.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Presence of CAD - angio (minimum 1 stenosis >=50%) | Presence of CAD in coronary angiography: minimum 1 stenosis >=50% | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Presence of CAD number - angio (Number of coronary vessels with at least 1 stenosis >=50% in coronary angiography) | Number of coronary vessels with at least 1 stenosis >=50% in coronary angiography | 1 day | 
| Wall motion abnormality - echo (Presence of wall motion abnormality in at least 1 segment (2D echocardiography) | Presence of wall motion abnormality in at least 1 segment (2D echocardiography) | 1 day | 
| Wall motion index - echo (Wall motion index (2D and 3D echocardiography) | Wall motion index (2D and 3D echocardiography) | 1 day | 
| Global longitudinal strain (2D and 3D echocardiography) | Global longitudinal strain (2D and 3D echocardiography) | 1 day | 
| Abnormal cardiogoniometry | Abnormal results of cardiogoniometry | 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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coronary artery disease, diagnosis, non-invasive