Apneic Oxygenation for Morbid Obese Parturient in cs

Study Overview
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Brief Summary
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The aim of this study is to compare the effect of apneic preoxygenation to conventional preoxygenation on the oxygen desaturation in morbid obese parturient performing elective caesarean section under general anesthesia.

Detailed Description
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Anesthetic management of the obese parturient is challenging. Both pregnancy and obesity are risk factors for a difficult airway and anesthesia-related maternal mortality. There is increased risk of difficult intubation associated with an increased difficultly in mask ventilation and increased risk of accelerated desaturation during apnea. The use of apneic oxygenation for the optimization of peri-intubation conditions is a promising means of preventing hypoxemia. Despite the recommendation of the use of nasal prongs to insufflate oxygen at flows of 5 L/min to 15 L/min during the apneic period randomized controlled trial is still not available in the morbidly obese parturient.

Official Title
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Effectiveness of Apneic Oxygenation for Morbid Obese Parturient Performing Elective Caesarean Section Under General Anesthesia

Conditions
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Morbid Obesity

Intervention / Treatment
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* Device: nasal prong


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Morbid obesity parturient defined as a body mass index (BMI) above 40 kg/m2. ASA physical status I-II Age above 18 years. Scheduled for elective caesarean section under general anesthesia. Exclusion Criteria: Parturient of ASA physical status III or above. Suspected or known difficult airway (Mallampati class > 2, reduced neck movement, reduced mouth opening, or Cormack-Lehane grade 4 recorded during a previous intubation procedure). Any contraindication for nasal prong use, for example, tumours, fractures or trauma. SpO2 ≤ 97% prior to preoxygenation.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Morbid obesity parturient defined as a body mass index (BMI) above 40 kg/m2. ASA physical status I-II Age above 18 years. Scheduled for elective caesarean section under general anesthesia.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: nasal prong.<br>the apneic preoxygenation group (30 patients), will receive 10 L/ min of O2 via nasal prong. | Device: nasal prong<br>* apneic preoxygenation group (30 patients), will receive 10 L/ min of O2 via nasal prong during preintubation apnia<br>|
| No Intervention: conventional<br>the conventional preoxygenation group (30 patients) | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the lowest oxygen saturation recorded | percentage | during intubation procedure | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| rates of desaturation below SpO2 90% | percentage | during intubation procedure | 
| rates of critical desaturation below SpO2 80% | percentage | during intubation procedure |