Propofol Versus Volatile Anesthesia in Post Operative Pain Management

Study Overview
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Brief Summary
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The study will test the hypothesis that patients anesthetized with propofol suffer less postoperative pain than those anesthetized with sevoflurane.

Detailed Description
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Patients undergoing s stripping operation for varicose veins will be randomized to one of two groups. Group 1 patients will receive propofol anesthesia. Group 2 patients will receive sevoflurane anesthesia. Intraoperative measurements including mean-arterial pressure, heart rate, propofol infusion rate, remifentanil infusion rate, and end-tidal sevoflurane concentration will be taken at 15 minute intervals. Patients in both groups will receive Piritramid as necessary to control pain either intravenously or through patient controlled pump. VAS pain score, mean-arterial pressure, heart rate, nausea will be evaluated at 30 minute intervals during the first four postoperative hours. Piritramid dosage and vomiting will be recorded through the first postoperative morning. Patients will rate pain based on the VAS score for the period between leaving the recovery room and the first postoperative morning

Official Title
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Do Patients Anesthetized With Propofol Have Less Pain Than Those Anesthetized With Volatile?

Conditions
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Varicose Vein, Postoperative Pain

Intervention / Treatment
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* Drug: propofol
* Drug: sevoflurane


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Participants will undergo a stripping operation for varicose veins Surgery will be performed by one physician only Written informed consent Exclusion Criteria: Any contraindications to the proposed interventions Procedures done under regional anesthesia

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: 1<br>Patients will receive propofol anesthesia during varicose vein stripping surgery. | Drug: propofol<br>* propofol anesthesia 3-5mg/kg<br>* Other names: Diprivan;|
| Active Comparator: 2<br>Patients will receive sevoflurane anesthesia during varicose vein stripping surgery. | Drug: sevoflurane<br>* sevoflurane anesthesia<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The primary outcome is morphine-equivalent use from the end of surgery until the first post-operative morning. |  | first post operative morning | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To determine the average pain score for each group during the first four hours of recovery after surgery. |  | 30 minute intervals for first 4 hours post operatively | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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postoperative pain, Piritramid, propofol, sevoflurane, varicose vein, Anesthesia