Beverage Hydration Index of Commercial Therapeutic Beverages

Study Overview
=================
Brief Summary
-----------------
The beverage hydration index (BHI) assesses the hydration potential of any consumable fluid relative to water. The BHI is a relatively new metric. Our purpose was to assess the BHI of beverages never previously tested, including an amino acid-based oral rehydration solution (AA-ORS), a glucose-containing ORS (G-ORS) and a sports drink (SD) compared to water (control).

Detailed Description
-----------------
The Beverage Hydration Index (BHI) was created to assess the degree to which beverages hydrate, by measuring fluid retention after ingesting a 1 liter bolus and comparing it to water. Drinks with carbohydrates and electrolytes would traditionally be expected to score higher on the BHI due to glucose-sodium cotransport at the gut and osmolality approaching isotonicity with blood. One recent study reported that an oral rehydration solution (ORS) scored better than water, but a sports drink did not. No optimal BHI beverage composition has been described, nor has an optimal osmolality. Recently, a hypotonic amino acid-based rehydration beverage was developed to take advantage of amino acid-sodium cotransport, thus obviating the need for carbohydrate. However, the BHI of this beverage has not yet been assessed. The purpose of this investigation was to assess the hydration potential of this novel beverage in comparison to a commercially available carbohydrate-containing sports drink and oral rehydration solution.

Official Title
-----------------
Beverage Hydration Index of Three Commercial Oral Rehydration Therapy ORT Beverages

Conditions
-----------------
Healthy

Intervention / Treatment
-----------------
* Other: enterade
* Other: Pedialyte
* Other: Gatorade
* Other: Water


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy male or female Aged 18-35 BMI 18-27 kg/m2 No known cardiovascular, renal or metabolic disease Moderately active Moderate alcohol use Exclusion Criteria: Overweight or obese (BMI >27 kg/m2) Competitive athletes during competition season Current or former cardiovascular, renal or metabolic disease Habitual consumption of alcohol (>21 units/week) or regular (>1/week) high (10 units) intake* History of psychiatric illness Actively seeking to gain or lose weight Currently taking prescribed medication Example, a 750 ml bottle of wine at 12% ABV contains 0.750 Liters * 12 = 9 units

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Intervention Model: Single Group Assignment
Interventional Model Description: Repeated-measures design with generalized latin square arrangement. Each participant will complete 4 separate trials.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Beverage Hydration Index of beverages<br>Subjects will consume 4 different beverages to obtain the beverage hydration index. | Other: enterade<br>* Subjects will consume enterade, which is an amino acid-based oral rehydration solution.<br>Other: Pedialyte<br>* Subjects will consume Pedialyte<br>Other: Gatorade<br>* Subjects will consume Gatorade<br>Other: Water<br>* Subjects will consume water as the control beverage<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Beverage hydration index | beverage hydration index | 4 hours | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
fluid balance, dehydration, rehydration, electrolytes, urine