Effect of Early Pain Management at Triage on Opioid Consumption

Study Overview
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Brief Summary
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introduction: Pain remains one of the most common reasons of emergency department admission. Opioids are overprescribed in emergency departments to treat severe pain. objective: assessing the impact of ealy pain pain management on the use of intravenous morphine and on patient satisfaction.

Official Title
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Effect of Early Analgesic Treatment on Opioid Consumption

Conditions
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Acute Pain

Intervention / Treatment
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* Drug: Paracetamol
* Drug: Tramadol/Paracetamol combination
* Drug: Placebo Oral Tablet


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: over 18 years of age a visual analog scale (VAS) equal to or higher than 30/100 , having given consent to participation No contraindications to products used in the course of the study. Exclusion Criteria: having a vital distress that does not allow an adequate assessment of the intensity of the pain an inability to assess pain intensity according to the VAS, swallowing disorders or inability , or a contraindication or an allergy to the treatments used.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: group Placebo<br>Patients in this group (Placebo Oral Tablet) received two placebo tablets | Drug: Placebo Oral Tablet<br>* 2 tablets of placebo<br>|
| Active Comparator: group Paracetamol<br>Patients in this group received two 500 mg paracetamol tablets | Drug: Paracetamol<br>* 2 tablets of 500mg of paracetamol<br>|
| Active Comparator: group Tramadol/Paracetamol combination<br>Patients in this group (Tramadol/Paracetamol combination ) received 2 tablets of Tramadol/Paracetamol combination (37.5mg/325mg) | Drug: Tramadol/Paracetamol combination<br>* 2 tablets of tramadol/paracetamol combination (32.5mg/325mg)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| use of rescue opioids | decreased consumption of intravenous morphine | DURING emergency department stay | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| patient satisfaction | patient satisfaction regarding the overall management in the emergency department measured by likert scale | When quitting emergency department | 
| Length of emergency department stay |  | Until emergency department discharge | 
| Pain intensity at emergency department discharge | Percentage of patients with visual analog scale <30 | At emergency department discharge | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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acute pain, emergency department, opioid consumption