Ketorolac as an Adjuvant Agent for Postoperative Pain Control Following Arthroscopic ACL Surgery

Study Overview
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Brief Summary
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The investigators aim to examine the use of IV and oral ketorolac as an adjunctive agent to the standard of care pain protocol for postoperative pain control following ACL reconstruction surgery. The investigators hypothesize that the use of IV and oral ketorolac in addition to the standard of care pain protocol will reduce postoperative opioid consumption following ACL reconstruction surgery.

Official Title
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Ketorolac as an Adjuvant Agent for Postoperative Pain Control Following Arthroscopic ACL Surgery

Conditions
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ACL Injury, Postoperative Pain

Intervention / Treatment
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* Drug: Ketorolac
* Drug: Oxycodone-Acetaminophen


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients between 18 and 89 years old Patients undergoing primary anterior cruciate ligament (ACL) reconstruction surgery Exclusion Criteria: Patients below age 18 or above age 89 Illiterate or non-English speaking individuals Patients with contraindications to Ketorolac History of chronic alcohol or drug abuse Chronic use of psychotropic or analgesic drugs Known peptic ulcer disease or bleeding diasthesis Renal dysfunction (estimated glomerular filtration rate < 50 mL/min/1.73m2) Breastfeeding women Pregnant women

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 89 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Control<br>Patients receive oxycodone- acetaminophen (5mg-325mg) 28 tablets PRN for pain following ACL reconstruction surgery | Drug: Oxycodone-Acetaminophen<br>* Oral oxycodone-acetaminophen for post-operative pain control<br>|
| Experimental: Ketorolac<br>Patients receive IV ketorolac followed by ketorolac 10 mg every 6 hours for 3 days following ACL reconstruction surgery. Patients are additionally discharged with oxycodone- acetaminophen (5mg-325mg) 28 tablets PRN for additional pain control | Drug: Ketorolac<br>* Oral ketorolac for pain control following ACL reconstruction surgery<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative Visual Analogue Scale Scores | Patients will record their pain on a visual analogue scale with a minimum score of 0 and a maximum score of 100 where lower values indicate a lower pain level, and higher values indicate a higher pain level. | Up to 8 weeks postoperative | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Narcotic Medication | Number of oxycodone-acetaminophen tablets | 5 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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ACL reconstruction, Ketorolac, Pain, Narcotic