Neuropsychological Outcomes of Internationally-Adopted Children Who Are Perinatally-Infected With Human Immunodeficiency Virus

Study Overview
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Brief Summary
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Children who are perinatally-infected with HIV are extremely vulnerable to cognitive delays and psychiatric disease, and the risk for neuropsychiatric illness is compounded in children who are internationally-adopted and may have suffered trauma, abandonment, malnutrition and neglect. While cognitive and psychiatric issues have been described in HIV-infected children, and even more so in HIV-positive adults, there have been no reports on neuropsychiatric interventions that can improve cognitive and psychiatric states in this highly vulnerable population. Without these needed data, Pediatric HIV providers have not been able to advocate for optimal neuropsychiatric care in perinatally HIV-infected children, let alone those who has suffered the additional risk of being internationally adopted. In the proposed study, the investigators will report on the neuropsychological profiles and outcomes in a cohort of internationally-adopted, perinatally HIV-infected children between ages 6 to 16 years who have not previously undergone neuropsychological testing or treatment. Data obtained from this study will provide important contributions to the literature by building understanding of the complex needs of this population as well as guiding future intervention efforts. The investigators predict that intervention efforts aimed at helping educators understand the learning and cognitive challenges for many of our patients will guide targeted academic supports in the school setting and lead to gains in academic skills. The detailed information obtained during the comprehensive neuropsychological assessment and follow-up care will be shared with the child's key educators at school so that individualized educational strategies can be developed, while maintaining confidentiality regarding the child's HIV status.

Official Title
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Neuropsychological Outcomes of Internationally-Adopted Children Who Are Perinatally-Infected With Human Immunodeficiency Virus

Conditions
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HIV/AIDS

Intervention / Treatment
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* Other: Neuropsychological testing


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Perinatally infected with HIV, internationally adopted Exclusion Criteria: Prior neuropsychological testing

Ages Eligible for Study
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Minimum Age: 6 Years
Maximum Age: 16 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Single Arm; all receive neuropsychological testing & follow-up<br> | Other: Neuropsychological testing<br>* Comprehensive neuropsychological assessment and implementation of appropriate support and resources.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Rating scales of behavioral and social/emotional functioning | Parental reporting | 24-36 months | 
| Change in Score of Wechsler Intelligence Scale for Children - Fifth Edition |  | 24-36 months | 
| Change in Score of Wechsler Individual Achievement Test - Third Edition |  | 24-36 months | 
| Change in Score of Gordon Diagnostic System |  | 24-36 months | 
| Change in Score of Grooved Pegboard |  | 24-36 months | 
| Change in Score of Token Test for Children - Second Edition |  | 24-36 months | 
| Change in Score of Wide Range Assessment of Memory and Learning - Second Edition |  | 24-36 months | 
| Change in Score of Delis Kaplan Executive Function System: Selected Subtests |  | 24-36 months | 
| Change in Score of Rey-Osterrieth Complex Figure Test |  | 24-36 months | 
| Change in Score of Beery-Buktenica Developmental Test of Visual Motor Integration - Sixth Edition |  | 24-36 months | 
| Change in Score of Peabody Picture Vocabulary Test - Fourth Edition |  | 24-36 months | 
| Change in Score of Behavior Assessment System for Children - Second Edition: Self, Parent, and Teacher Reports |  | 24-36 months | 
| Change in Score of Pediatric Sleep Questionnaire |  | 24-36 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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HIV/AIDS, international adoption, perinatal infection, neuropsychological outcomes