Trends Over Time (1990-2010) of Diarrhoea-related Incidence, Hospitalizations and Deaths in Children of Panama

Study Overview
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Brief Summary
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This study aims at collecting data from secondary sources to obtain baseline incidence and monitor trends over time (1990 - 2010) of reported gastroenteritis cases, gastroenteritis related hospital discharges and gastroenteritis related deaths in children < 5 years of age in Panama before and after implementation of Rotarix™ universal mass vaccination.

Detailed Description
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Data will be collected from systematic review of the databases of epidemiologic surveillance system, hospital discharges and deaths for all cause gastroenteritis related outcomes.

Official Title
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Time Trend Analysis of Diarrhoea-related Incidence, Hospitalizations, and Deaths in Children < 5 Years of Age in Panama by Monitoring Secondary Data Sources From 1990-2010

Conditions
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Gastroenteritis

Intervention / Treatment
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* Other: Epidemiologic Surveillance System of the Ministry of Health of Panama
* Other: Mortality database of the Contraloria General de la Republica
* Other: Hospital discharge records


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diarrhea cases, diarrhea associated hospital discharges, and diarrhea related deaths occurring in children <5 years of age during the period analyzed and registered in the Epidemiologic Surveillance System of the Ministry of Health, in the mortality database of the Contraloría General de la República and in the hospital discharge records of the selected hospitals, will be collected for the study. Exclusion Criteria: Not applicable

Ages Eligible for Study
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Maximum Age: 59 Months

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Gastroenteritis Group<br>All children suffering with gastroenteritis | Other: Epidemiologic Surveillance System of the Ministry of Health of Panama<br>* Reviewing the Epidemiologic Surveillance System of the Ministry of Health of Panama<br>Other: Mortality database of the Contraloria General de la Republica<br>* Reviewing the Mortality database of the Contraloria General de la Republica<br>Other: Hospital discharge records<br>* Reviewing the hospital discharge records<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Occurrence of all cause reported gastroenteritis |  | In post vaccine introduction period (2006-2010) compared to pre-vaccination period (1990-2005) | 
| Occurrence of all cause gastroenteritis related hospital discharges |  | In post vaccine introduction period (2006-2010) compared to pre-vaccination period (2000-2005) | 
| Occurrence of all cause gastroenteritis related deaths. |  | In post vaccine introduction period (2006-2010) compared to pre-vaccination period (1990-2005) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Occurrence of all cause gastroenteritis-related cases by year, age groups and region |  | From 1990 to 2010 | 
| Occurrence of all cause gastroenteritis related hospital discharge by year, age groups, hospital and setting |  | From 2000 to 2010 | 
| Occurrence of all cause gastroenteritis related deaths by year, age groups and region |  | From 1990 to 2010 |