Assessment of Professional Practices in Muscle Rehabilitation of Chronic Hemodialysis

Study Overview
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Brief Summary
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Aim of this study is to evaluate, in a population of chronic kidney disease patients on dialysis (Stage 5D), the effect of a muscle strengthening program (training against resistance vs endurance training by elliptical bike) during a observational period (12 weeks per program) on frailty, risk of falling, muscle strength and mass, endurance, physical activity, quality of dialysis, nutritional status and neuromuscular sensitivity.

Official Title
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Assessment of Professional Practices in Muscle Rehabilitation of Chronic Hemodialysis

Conditions
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Chronic Kidney Diseases

Intervention / Treatment
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* Procedure: Lymphatic drainage


Participation Criteria
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Eligibility Criteria
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Inclusion criteria: Chronic Kidney Disease patient on dialysis (stage 5D) for more than 3 months Age > 18 years old Stable clinical condition Absence of musculoskeletal disorders Exclusion criteria: Cardiovascular contraindication Amputation of lower limb not allowing use of elliptical bike

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| muscle strengthening program<br>All patients will be receiving a muscle strengthening program consisting in both a training against resistance and an endurance training by elliptical bike during an observational period of 12 weeks for each treatment. Each training program will be preceded by a 4-week period of lymphatic drainage in order to improve neuromuscular sensitivity. | Procedure: Lymphatic drainage<br>* Lymphatic drainage<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in functional autonomy (frailty) after training | Change in functional autonomy (frailty) after training | 4 weeks after inclusion | 
| Change in functional autonomy (frailty) after training | Change in functional autonomy (frailty) after training | 12 weeks after inclusion | 
| Change in functional autonomy (frailty) after training | Change in functional autonomy (frailty) after training and endurance training by elliptical bike during an observational period (12 weeks per program). | 16 weeks after inclusion | 
| Change in functional autonomy (frailty) after training | Change in functional autonomy (frailty) after training and endurance training by elliptical bike during an observational period (12 weeks per program). | 32 weeks after inclusion | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in risk of falling after training | Change in risk of falling after training | 4, 12, 16 and 32 weeks after inclusion | 
| Change in muscle strength and mass after training | Change in muscle strength and mass after training | 4, 12, 16 and 32 weeks after inclusion | 
| Change in endurance after training | Change in endurance after training | 4, 12, 16 and 32 weeks after inclusion | 
| Change in physical activity after training | Change in physical activity after training | 4, 12, 16 and 32 weeks after inclusion | 
| Change in quality of dialysis after training | Change in quality of dialysis after training | 4, 12, 16 and 32 weeks after inclusion | 
| Change in nutritional status after training | Change in nutritional status after training | 4, 12, 16 and 32 weeks after inclusion | 
| Change in neuromuscular sensitivity after training | Change in neuromuscular sensitivity after training | 4, 12, 16 and 32 weeks after inclusion | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Chronic Kidney Disease patient on dialysis (stage 5D), Muscle mass and strength, Training, Survival