The Usage of High-resolution Magnetic Resonance Imaging in Patients With Post-stroke Aphasia for Predicting the Outcome

Study Overview
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Brief Summary
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Combined analysis of functional and structural language network changes may be a good model for predicting language outcome.

Detailed Description
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Background & objectives: Language impairment after aphasic stroke is both common and debilitating. However the mechanisms of language recovery after aphasic stroke is not fully understood. Investigators plan to detect the changes of functional and structural language networks after aphasic stroke by high-resolution MRI.Then Combined analyse functional and structural language network changes, establishing a prediction model for language outcome. Methods: The proposed study is a observational trial that will include 50 patients diagnosed with post stroke aphasia from the neurology clinics at The First Affiliated Hospital, Zhejiang University. Aphasia battery of Chinese(ABC) and functional magnetic resonance imaging (MRI) will be performed at acute( 2weeks),subacute(3 months) and chronic phase(6months). Only routine drug therapy will be used. Relevance: Currently there is little known about the recovery mechanisms of post-stroke aphasia.The proposed study intends to analyse functional and structural language network changes by high resolution MRI, which may reveal the potential recovery mechanism underlying post stroke aphasia..

Official Title
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The Usage of High-resolution Magnetic Resonance Imaging in Patients With Post-stroke Aphasia for Predicting the Outcome

Conditions
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Aphasia

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy right-handed native Chinese speakers with more than 6-year education are recruited as healthy controls. Exclusion Criteria: Not right-handed; Any use of psychoactive drugs; Less than 6-year education; Not suitable for MRI scan.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Aphasia<br>Post stroke aphasia patients without any additional interventions for research purposes. | |
| Control<br>Healthy controls | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Resting state functional connectivity changes | The study uses resting state functional MRI(rs-fMRI) to measure changes of functional connectivity across regions after a spontaneous recovery. | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Aphasia Battery of Chinese, ABC | ABC, the Chinese standardized adaptation of the Western Aphasia Battery, indicates the patient's ability of spontaneous speech, auditory comprehension, repetition, naming, reading, writing. | 3 months | 
| White matter Integrity | The study uses Diffusion tensor imaging and tracking (DTI) to measure changes of the Integrity of white matter after a spontaneous recovery. | 3 months | 
| Brain response change | The study uses task functional MRI (fMRI) to measure the brain response changes during the task after a spontaneous recovery. | 3 months | 
| Resting state functional connectivity changes | The study uses resting state functional MRI(rs-fMRI) to measure changes of functional connectivity across regions after a spontaneous recovery. | 6 months | 
| Aphasia Battery of Chinese, ABC | ABC, the Chinese standardized adaptation of the Western Aphasia Battery, indicates the patient's ability of spontaneous speech, auditory comprehension, repetition, naming, reading, | 6 months | 
| White matter Integrity | The study uses Diffusion tensor imaging and tracking (DTI) to measure changes of the Integrity of white matter after a spontaneous recovery. | 6 months | 
| Brain response change | The study uses task functional MRI (fMRI) to measure the brain response changes during the task after a spontaneous recovery. | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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resting-state, DTI, aphasia, stroke