Evolution of the Physical Condition in Treated Cancer Patients

Study Overview
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Brief Summary
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Adaptated Physical Activity (APA) during treatment of cancer is one of the actual global health recommendation because of the benefits observed in several parameters evaluated in many clinical studies. A best knowledge of the physical and medical characteristics of patients, including type of cancer and type of treatment, is primordial to optimize the patient care and the effectiveness of APA programs. Descriptive, explorative and prospective study of 3 different populations: One population with locally advanced or metastatic non-small cell lung cancer treated with multiple therapeutic lines. Two different populations of early cancer patients and treated with a platinum-based regimen for colon cancer and a taxane-based chemotherapy for breast cancer.

Official Title
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Evolution of the Physical Condition in Treated Cancer Patients

Conditions
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Non-small Cell Lung Cancer Metastatic, Breast Cancer Female, Colon Cancer

Intervention / Treatment
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* Other: Adaptated Physical Activity


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Woman with breast cancer treated with adjuvant chemotherapy (taxane) or patient with colon cancer treated with adjuvant regimen (FOLFOX) or patient with locally advanced or metastatic lung cancer Patient without contraindication to the study-specific assessments Eastern Cooperative Oncology Group ≤ 2 Age ≥ 18 years old Life expectancy > 6 months Able to speak, read and understand French Written informed consent obtained from the patient Registration in a national health care system Exclusion Criteria: Patient with psychiatric, neurologic or musculoskeletal disorders Pregnant or breastfeeding women Minor or protected adult

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: experimental: observational cohort<br>Evaluation of the physical condition and the quality of life | Other: Adaptated Physical Activity<br>* Evaluation of the physical condition and the quality of life during the course of treatment (after 8 weeks of treatment) and at the end of the treatment's line (except for breast cancer patients)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| evolution of exercise tolerance | To describe exercise tolerance, by a six-minute walk test, in patients treated for a cancer (of lung, breast or colon) after 8 weeks of treatment. | change from baseline exercise tolerance at 12 weeks after the end of the treatment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| measurement of parameters reflecting the physical condition | To describe objective and felt fatigue by Fonctional assessment of chronic illness therapy-fatique (41 items scale) | change from baseline physical condition at 12 weeks after the end of the treatment | 
| measurement of parameters reflecting the physical condition | To describe muscular strenght by FPmax: Maximal strenght of finger flexors; (measured in Newton with a dynamometer) | change from baseline physical condition at 12 weeks after the end of the treatment | 
| measurement of parameters reflecting the physical condition | To describe muscular strenght by IFP: Fatigability indexof finger flexors; (measured in Newton with a dynamometer) | change from baseline physical condition at 12 weeks after the end of the treatment | 
| measurement of parameters reflecting the physical condition | To describe muscular strenght by FIEmax: Maximal isometric strenght of knee extensors; (measured in Newton with a dynamometer) | change from baseline physical condition at 12 weeks after the end of the treatment | 
| measurement of parameters reflecting the physical condition | To describe muscular strenght by IFE: Fatigability index of knee extensors; (measured in Newton with a dynamometer) | change from baseline physical condition at 12 weeks after the end of the treatment | 
| measurement of the lean body mass condition | To describe lean body mass by impedancemeter | change from baseline physical condition at 12 weeks after the end of the treatment | 
| measurement of the pulmonary function | Spirometry measures lung function, specifically the amount (volume) of air that can be inhaled and exhaled | change from baseline physical condition at 12 weeks after the end of the treatment | 
| measurement of parameters reflecting the physical condition | To describe anxiety by Hospital Anxiety and Depression scale (14 items) | change from baseline physical condition at 12 weeks after the end of the treatment | 
| measurement of parameters reflecting the physical condition | To describe physical activity level by by Global Physical Activity questionnaire | change from baseline physical condition at 12 weeks after the end of the treatment | 
| measurement of parameters reflecting the physical condition | To describe physical performance index by Short Physical Performance Battery which is a group of measures that combines the results of the gait speed | change from baseline physical condition at 12 weeks after the end of the treatment | 
| measurement of parameters reflecting the physical condition | To describe physical performance index by Short Physical Performance Battery which is a group of measures that combines the results of the chair stand | change from baseline physical condition at 12 weeks after the end of the treatment | 
| measurement of parameters reflecting the physical condition | To describe physical performance index by Short Physical Performance Battery which is a group of measures that combines the results of the balance tests | change from baseline physical condition at 12 weeks after the end of the treatment |