Effects of Thyroid Hormone Withdrawal on Metabolic Parameters During Radioactive Iodine Therapy in Thyroid Cancer

Study Overview
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Brief Summary
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The incidence of differentiated thyroid cancer is increasing in Korea. A significant number of them experience severe hypothyroidism in preparation for radioactive iodine (RAI) therapy after total thyroidectomy. Because the function of thyroid hormone is closely linked with lipid and glucose metabolism, overt hypothyroidism after thyroid hormone withdrawal during RAI therapy may induce the changes of metabolic parameters. We investigate the effects of thyroid hormone withdrawal on metabolic and cardiovascular parameters during radioactive iodine therapy in differentiated thyroid cancer.

Detailed Description
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Study design measurement of various parameters during hypothyroid state (before 1 month, the day and after 1 month of RAI therapy) Measurements Measurement of metabolic and cardiovascular parameters glucose profiles : HbA1c, fasting glucose level lipid profiles : free fatty acid, total, LDL-, HDL-, cholesterol, triglyceride adipocytokines : retinol binding protein(RBP) 4, leptin, resistin, adiponectin markers of endothelial and cardiac function : high-sensitivity C-reactive protein(hsCRP), homocystein, B-type natriuretic peptide(BNP) bone turnover markers : CTX, bone ALP Scoring of symptoms and signs of hypothyroidism (Zulewski score) symptoms physical signs

Official Title
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Effects of Thyroid Hormone Withdrawal on Metabolic and Cardiovascular Parameters During Radioactive Iodine Therapy in Differentiated Thyroid Cancer

Conditions
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Hypothyroidism

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: radioiodine therapy after total thyroidectomy in differentiated thyroid cancer age over 18 Exclusion Criteria: kidney failure, liver failure, heart failure infection inflammation autoimmune disease other chronic disease

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Hypothyroidism for RAI<br>The group of patients who experience hypothyroidism after thyroid hormone withdrawal for radioactive iodine(RAI) therapy | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes of metabolic parameters | glucose profiles : HbA1c, fasting glucose level lipid profiles : free fatty acid, total, LDL-, HDL-, cholesterol, triglyceride adipocytokines : retinol binding protein(RBP)4, leptin, resistin, adiponectin markers of endothelial and cardiac function : high-sensitivity C-reactive - protein(hsCRP), homocystein, B-type natriuretic peptide(BNP) | Before 1month of radioiodine therapy, Day of radioiodine therapy, After 1 month of radioiodine therapy | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes of bone turnover markers | bone formation marker: bone ALP bone resorption marker: CTX | Before 1month of radioiodine therapy, Day of radioiodine therapy, After 1 month of radioiodine terapy | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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thyroid cancer, hypothyroidism, metabolic parameters, Hypothyroidism after levothyroxine withdrawal