A Research on Hidden Blood Loss in Open Radical Hysterectomy and Pelvic Lymphadenectomy

Study Overview
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Brief Summary
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The aim of this cross-sectional study is to evaluate the hidden blood loss in patients who underwent open radical hysterectomy and identity its risk factors.

Detailed Description
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The electronic medical data of 100 patients who undergo open radial hysterectomy in the following year to treat cervical cancer will be analyzed retrospectively in this study. The amount of hidden blood loss will be calculated according to Gross's formula. And multiple linear regression analysis will be employed to identify its risk factors.

Official Title
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A Research on Hidden Blood Loss in Open Radical Hysterectomy and Pelvic Lymphadenectomy

Conditions
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Hidden Blood Loss, Open Radical Hysterectomy, Cervical Cancer

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Volunteer to participate in the study with informed consent; Females aged 20-80 who are confirmed with cervical cancer and are treated with open radical hysterectomy and pelvic lymphadenectomy. Exclusion Criteria: Pregnancy, lactation, postmenopause, or planned pregnancy within two years; Suspected or identified as other tumors of genital tract; History of hyperparathyroidism, infectious diseases (tuberculosis, AIDS), autoimmune diseases, or digestive system diseases (malabsorption, crohn disease and dysentery); Other diseases or heavy injuries that will interfere with the results; Simultaneous participation in another clinical study with investigational medicinal product(s) or researcher thinks the subjects are not suitable for this trial.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| open radical hysterectomy<br>The patients who would undergo open radical hysterectomy procedure. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the volume of hidden blood loss (mL) | the volume of invisible blood loss occurring in patients who undergo open radical hysterectomy applying Gross's formula | 10 months after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the risk factors of hidden blood loss | Performing multiple linear regression analysis with SPSS 17.0, we plan to identify the factors which may increase the volume of hidden blood loss from possible factors like hypertension, diebetes, etc. | 10 months after surgery | 
| the volume of total blood loss (mL) | the vomule of patients' blood loss through the whole perioperative time according to the method of Nadler | 10 months after surgery | 
| the volume of visible blood loss (mL) | the visible blood loss including the blood in the suction bottle and in weighed compresses during the operation and the drainage volume after the operation | 10 months after surgery |