Attentional Impairment in People With Epilepsy

Study Overview
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Brief Summary
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Epilepsy is one of the most common chronic neurological conditions.It leads to cognitive impairment in 20-50% of patients with a structural form. In comparison with seizures, these cognitive disorders are a major additional factor in occupational, social and family disability. They are particularly frequent (50%) in temporal epilepsies and preferably concern memory and language skills. The cognitive consequences of epilepsy are therefore well described in the following areas: episodic memory, language, executive functions. Concerning attentional abilities, a recent review has highlighted the lack of work in this specific field in order to properly measure the prevalence and nature of attentional disorders in epileptic patients. Indeed, attentional abilities are often mentioned in studies, but attention is a complex domain defined by four modalities: alertness, selective attention, divided attention and sustained attention. No study systematically assesses all of these modalities. The objective of this study is to evaluate the prevalence and nature of attentional disorders in epileptic patients compared to control subjects.

Official Title
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Attentional Impairment in People With Epilepsy

Conditions
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Epilepsy

Intervention / Treatment
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* Other: Attentional tasks


Participation Criteria
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Eligibility Criteria
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Patients: Inclusion Criteria: Patient with epilepsy, according to Fisher et al. (2005). Patient with written informed consent affiliation to a social security regime is compulsory Individuals who have received full information about the organization of the research and have not objected to their participation and the use of their data. Patient 18 years of age and older Normal controls: Individuals who have received full information about the organization of the research and have not objected to their participation and the use of their data. People 18 years of age and older People with no neurological and/or psychiatric history Exclusion Criteria: for patients: with another progressive neurological condition for all People of full age who are subject to a legal protection measure or who are unable to express their consent People deprived of their liberty by a judicial or administrative decision People who regularly use psychoactive substances (cannabis, alcohol...)

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| patients with epilepsy<br>Attentional tasks : D2-R task and TAP battery (sustained attention, alertness, divided attention) executive task : digit span, incompatibility and flexibility task (TAP battery), verbal fluencies depression score (NDDI-E scale) and anxiety score (GAD-7 scale) | Other: Attentional tasks<br>* a neuropsychological assessment of attentional task, executive task and interview is proposed to patients or normal control<br>|
| Normal controls<br>Attentional tasks : D2-R task and TAP battery (sustained attention, alertness, divided attention) executive task : digit span, incompatibility and flexibility task (TAP battery), verbal fluencies depression score (NDDI-E scale) and anxiety score (GAD-7 scale) | Other: Attentional tasks<br>* a neuropsychological assessment of attentional task, executive task and interview is proposed to patients or normal control<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| d2-r | selective attention task | 10 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| sustained attention TAP Subtest | Your task is to press the key as quickly as possible whenever two successive patterns have the same shape | 15 minutes | 
| alertness attention TAP Subtest | a cross appears on the screen. press the key when the cross appears | 8 minutes | 
| divided attention TAP Subtest | first task :a cross appears on the screen in which a varying number of crosses appear simultaneously. when four of these crosses form a square, then please press the key as quickly as possible. second task: in this task you will hear a high and a low tone in sequence. you must decide whether the same tone occurs twice in a row. Please press the key as quickly as possible. | 5 minutes |