Hepatopulmonary Syndrome and Postoperative Complications After Liver Transplantation : A Case-control Study

Study Overview
=================
Brief Summary
-----------------
Hepatopulmonary Syndrome is a respiratory complication of liver cirrhosis defined as a triad: hypoxemia (PaO2 < 80 mmHg in room air), chronic liver disease and intrapulmonary vasodilatations. Its prevalence varies between 4 and 32%. Numerous treatments have been tried but the only efficient therapy to cure the syndrome is liver transplantation. Without transplantation it is associated with a higher mortality which is the reason why hepatopulmonary syndrome patients have a higher priority to transplantation. However it appears in some restricted studies that hepatopulmonary syndrome is associated with more postoperative complications (infections, vascular and biliary complications, prolonged length of mechanical ventilation…). The investigators hypothesised that hepatopulmonary syndrome patients have more postoperative complications after liver transplantation than non hepatopulmonary syndrome patients matched on age, MELD (Model for End-Stage Liver Disease) score, comorbidities, perioperative transfusion and noradrenaline doses.

Official Title
-----------------
Hepatopulmonary Syndrome and Postoperative Complications After Liver Transplantation : A Case-control Study.

Conditions
-----------------
Hepatopulmonary Syndrome, Liver Cirrhosis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Liver transplanted patients Exclusion Criteria: Living donor transplantation Bipartition transplantation Non-heat-beating donor transplantation Minor Double or multiple organ transplantation Non cirrhotic patients Retransplantation

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| hepatic transplant patients with hepatopulmonary syndrome<br> | |
| hepatic transplant patients without hepatopulmonary syndrome<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative complication rates in hepatic transplant patients with or without hepatopulmonary syndrome | Collection of medical (cardiac, pulmonary, renal, infectious, neurological) and Surgical (vascular, digestive) complications in hepatic transplant patients with or without hepatopulmonary syndrome | 1 year post liver transplantation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Length of Mechanical Ventilation |  | 1 year post liver transplantation | 
| Length of ICU stay |  | 1 year post liver transplantation | 
| Length of Hospital Stay |  | 1 year post liver transplantation | 
| Delay of hepatopulmonary syndrome resolution |  | 1 year post liver transplantation | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Liver transplantation, Hepatopulmonary Syndrome, Liver Cirrhosis