Myofascial Therapy in Patients With Hemophilic Arthropathy

Study Overview
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Brief Summary
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Designing a treatment protocol using myofascial therapy for the treatment of pain and restrictions on mobility in patients with hemophilic arthropathy of the knee and ankle. Pilot with a small number of patients for assessment the effectiveness and safety of the treatment protocol created. Randomized clinical trial to assess the effectiveness of treatment with myofascial therapy in patients with hemophilia. Describe the differences in terms of the dependent variables (range of motion, pain and flexibility) in patients with hemophilia who have carried out the treatment. Report the relationship between the clinical characteristics of patients and the results obtained after the treatment period.

Detailed Description
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Phase I pilot study with 5 patients with hemophilia for assessment by myofascial therapy protocol designed for this purpose. Phase II. Randomized, prospective longitudinal clinical study in patients with hemophilia, to assess the efficacy of an intervention with myofascial therapy.

Official Title
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Physiotherapy Protocol by Myofascial Therapy and Randomized Clinical Study in Patients With Hemophilic Arthropathy

Conditions
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Hemophilia

Intervention / Treatment
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* Other: Myofascial therapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with a diagnosis of hemophilia A and B. Patients older than 18 years. Patients with a diagnosis of hemophilic arthropathy of the knee and ankle. Patients on prophylactic regimen with FVIII / FIX. Exclusion Criteria: Patients without walking ability. Patients with a diagnosis of other congenital coagulopathy (eg von Willebrand disease). Patients who have developed antibodies to FVIII / FIX (inhibitors). Patients with neurological or cognitive impairments that impede understanding of questionnaires and physical test. Patients who have not signed the informed consent document.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Experimental group<br>Treatment through myofascial therapy for the treatment of pain and restricted mobility in patients with hemophilic arthropathy of the knee and ankle | Other: Myofascial therapy<br>* Maneuver of pressure and sliding over the anterolateral compartment of the leg Maneuver of pressure and sliding on the back of the leg Liberation technique of the popliteal fascia Maneuver of pressure and sliding on the anterior thigh Maneuver of pressure and sliding on the iliotibial tract Maneuver of pressure and sliding on the hamstring muscle region. Induction maneuver of ankle anterior compartment Induction maneuver of knee anterior chamber<br>|
| No Intervention: Control group<br>No myofascial intervention. Patients continue their treatment with FVIII or FIX concentrates, normally | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Bleeding frequency | Change from number of bleeding during treatment and follow-up period at 1 month | Screening visit, within the first seven days after treatment and after one month follow-up visit | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain | Change from joint pain during treatment and follow-up period at 1 month | Screening visit, within the first seven days after treatment and after one month follow-up visit | 
| Joint function | Change from joint health during treatment and follow-up period at 1 month. Haemophilia Joint Health. Measurement instrument: Score and Gilbert score | Screening visit, within the first seven days after treatment and after one month follow-up visit | 
| Range of motion | Change from range of movement of ankle and knee during treatment and follow-up period at 1 month. Measurement instrument: universal goniometer with the protocol to measurement for patients with hemophilia | Screening visit, within the first seven days after treatment and after one month follow-up visit | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Haemophilia, Arthropathy, Pain, Range of motion, Miofascial techniques