Dual Hemisphere rTMS for Rehabilitation of Post Stroke Aphasia

Study Overview
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Brief Summary
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To investigate the therapeutic effect of dual hemisphere repetitive transcranial magnetic stimulation (rTMS) on post-stroke non fluent aphasia.

Detailed Description
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Thirty patients with subacute post-stroke non-fluent aphasia were randomly allocated with a ratio 2:1 to receive real (n = 20) or sham (n = 10) rTMS of the affected motor cortex. Each patient received 1000 rTMS pulses (1 Hertz at 110% of resting motor threshold) over the unaffected Broca's area and 1000 pulses (20 Hertz at 100% resting motor threshold) over affected left Broca's area for 10 consecutive days. LANGUAGE section of hemispheric stroke scale, Stroke Aphasic Depression Questionnaire Hospital Version (SADQ-H) and NIH stroke scale were assessed before, post sessions, 1 and 2 months after the last session . Motor threshold was assessed before and after the end of last session.

Official Title
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Treatment of Aphasic Stroke Patients With rTMS

Conditions
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Non Fluent Aphasia in Subacute Stroke

Intervention / Treatment
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* Procedure: repetitive transcranial magnetic stimulation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: acute hemiplegia with non-fluent aphasia, single thromboembolic non-haemorrhagic infarction documented by computerized tomography (CT) in the distribution of middle cerebral artery. Exclusion Criteria: head injury or neurological disease other than stroke, Unstable cardiac dysrhythmia, Fever, Infection, Hyperglycaemia Prior administration of tranquilizer Patients with no motor evoked response recorded from first dorsal interosseus (FDI) muscle of the affected hand
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Real rTMS<br>19 subacute stroke pts with aphasia received 10 rTMS (5sessions/week) for 2 successive weeks | Procedure: repetitive transcranial magnetic stimulation<br> <br> * Other names: rTMS;|
| Sham Comparator: Sham rTMS<br>10 patients received sham rTMS stimulation (5 sessions/week) for 2 successive weeks | Procedure: repetitive transcranial magnetic stimulation<br> <br> * Other names: rTMS;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hemispheric stroke scale (HSS) | Language assessment using hemispheric stroke scale (HSS) | Change from Baseline in HSS at 2 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| NIH Stroke Scale (NIHSS) |  | Change from Baseline in NIHSS at 2 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Aphasia, Stroke, repetitive transcranial magnetic stimulation.