Positron Emission Tomography of Infection and Vasculitis

Study Overview
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Brief Summary
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The purpose of this study is to evaluate the value of positron emission tomography/computed tomography in various inflammatory conditions caused by bacterial infection or vasculitis. Glucose analog FDG is sensitive to detect inflammation foci but we hypothesize that other imaging agents such as PK11195 and Ga-citrate may have added value in certain applications.

Detailed Description
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The purpose of this study is to evaluate the value of PET/CT in various inflammatory conditions caused by bacterial infection or vasculitis. Our aim is to: investigate whether FDG (18F-2-fluoro-2-deoxy-D-glucose fluorodeoxyglucose) PET/CT and 68Ga-(Gallium-68) citrate PET/CT enable the early and accurate detection of metastatic infection foci in Staphylococcus aureus bacteremia. study the usefulness of FDG PET/CT in detection of endovascular infection in bacteremia caused by Salmonella spp. find an optimal FDG PET/CT protocol for detection of infectious endocarditis and metastatic infection foci related to endocarditis. study the value of FDG PET/CT in the diagnosis of infection of pacemaker or implantable cardioverter defibrillator. investigate the usefulness of FDG PET/CT, 68Ga-citrate PET/CT, and 11C- (carbon-11) translocator protein ligand (PK11195) PET/CT in diagnosis of vasculitis and in imaging of the magnitude of the vascular changes.

Official Title
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Positron Emission Tomography of Infection and Vasculitis (PETU)

Conditions
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Infection, Vasculitis

Intervention / Treatment
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* Radiation: PET/CT


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adults with Staphylococcus aureus bacteremia or Salmonella spp. bacteremia or infective endocarditis or infection of pacemaker or implantable cardioverter defibrillator or vasculitis Exclusion Criteria: underage, pregnant, breastfeeding, handicapped or prisoner

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Staphylococcus aureus bacteremia<br>PET/CT in patients with Staphylococcus aureus bacteremia | Radiation: PET/CT<br>* positron emission tomography/computed tomography<br>|
| Salmonella spp. bacteremia<br>PET/CT in patients with Salmonella spp. bacteremia | Radiation: PET/CT<br>* positron emission tomography/computed tomography<br>|
| Endocarditis<br>PET/CT in patients with infective endocarditis | Radiation: PET/CT<br>* positron emission tomography/computed tomography<br>|
| Pacemaker infection<br>PET/CT in patients with pacemaker infection | Radiation: PET/CT<br>* positron emission tomography/computed tomography<br>|
| Vasculitis<br>PET/CT in patients with vasculitis | Radiation: PET/CT<br>* positron emission tomography/computed tomography<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Detection of infection or vasculitis in PET images |  | within 1 week after starting the treatment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Standardized uptake value of PET imaging agent at the site of infection or vasculitis |  | within 1 week after starting the treatment | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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PET/CT, infection, vasculitis