linjc16/ctgov huggingface dataset:
Prevelance of Keratoconus

Study Overview
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Brief Summary
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Keratoconus is a degenerative disease entity characterized by conical shape ectasia of the cornea. progressive conical deformation of the cornea leads to substantial astigmatism. Patients who are at an advanced stage of ectasia are often led to corneal transplant or other treatments, which essentially aim at correcting the refractive error and not in treating the ectasia. The top of the protruding cone that corneal configuration may be close to the visual axis or below and nasal of that. The disease manifests during adolescence, followed by slow progressive course, although it is possible to stabilize anytime. In 85% of cases both eyes are affected, but the severity of the attack can present significant asymmetry.

Detailed Description
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Often in keratoconus a positive family history is present. Prevelance of keratoconus varies greatly worldwide.The reported prevalence of keratoconus varies widely depending upon the geographic location, diagnostic criteria used, and the cohort of patients selected. Environmental factors may contribute to the wide variation in prevalence. the Middle East have higher prevalence than locations with cooler climates and less sunshine

Official Title
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Prevelance of Keratoconus in Individuals Attending Refreactive Surgery Centers in Assiut

Conditions
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Keratoconus

Intervention / Treatment
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* Other: opthalmologic examination


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: persons attending refractive surgery centers in Asssiut. patients found to have keratoconus are included , based on history , clinical examination and corneal topography Exclusion criteria : patients not attending those refractive surgery centers. patients attending these centers but not diagnosed to be keratoconus . Pregnancy or breastfeeding
Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| patients with keratoconus<br>patients with keratoconus attending refractive surgery centers in Assiut will be subjected to the following :- Full history and clinical evaluation. collection of individual data ( residency , occupation , special habbit , chronic illness ) Analysis of results to assess prevelance of keratoconus and its distribution geographically in Assiut | Other: opthalmologic examination<br>* opthalmologic examination : Refraction Best corrected visual acuity Intraocular pressure Slit lamp examination<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prevalence of keratoconus in different areas in assiut | Number of keratoconus cases detected areas in indivduals attending refractive surgery centers in Assiut | one year |
Two Cancers, One Gene. Why Some People in Families Develop Melanoma or Pancreas Cancer, While Still Others Never Develop Cancer.

Study Overview
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Brief Summary
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Individuals who are affected with pancreas cancer and melanoma as well as those without either cancer who have been identified as 1st or 2nd degree relatives of family members with pancreas cancer and melanoma will be asked to participate. The participant will be asked to complete a survey about their health and family history of cancer and to give a blood sample for specific gene testing and storage for future research studies.The overall goal of this study is to understand the factors that increase susceptibility and expression of pancreatic cancer and melanoma in high risk families.

Official Title
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Two Cancers, One Gene

Conditions
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Pancreas Cancer, Melanoma

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Individuals who are affected with pancreas cancer and melanoma as well as those without either cancer who have been identified as 1st or 2nd degree relatives of family members with pancreas cancer and melanoma. Exclusion Criteria: Under the age of 18, Non-English speaking or unable to provide informed consent, inmates.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Genomic and risk factor differences among family members who share identical predisposing CDKN2A gene mutations, with different phenotypes; will discover patterns of tumorigenesis, tissue specificity, gene-gene, and gene-environment interactions. | Genotypes of potential modifier genes will be identified in multiple kindreds that feature pancreatic cancer and melanoma and known to carry CDKN2A germline mutations. The investigators will then determine common germline variants in potential CDKN2A mutant carriers using targeted sequencing and search for genetic modifiers by performing Illumina HumanOmni5Exome-4 Beadchip with Infinium LCG on germline DNA. The Illumina microarray contains over 4.5 million markers, of which 528,675 are exonic, and includes over 2.6 million SNPs that would be considered common. The investigators will analyze the genetic and risk factor data collected through the completed surveys by participants using both statistical genetic and machine learning methods. As a means of extension and potential validation, the investigators will then similarly study up to 200 members who are mutation carriers in 39 other CDKN2A mutation-positive kindreds. | Each participant provides a research blood sample and completes a questionnaire.This is the duration of their the participant's direct involvement. The duration of generating genotypes and analysis of risk factors may extend up to two years. |
Causes of Disqualification of Egyptian Potential Living Liver Donors

Study Overview
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Brief Summary
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Due to absence of Deceased-donors in Egypt, Living-donor liver transplantation (LDLT) has emerged as an option to the traditional deceased-donor transplantation procedure. But there is an essential risk related to liver resection for healthy donors.

Detailed Description
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The aim of this work is to identify and analyze the causes of disqualification of potential Egyptian living liver-donors in a University based liver transplant program

Conditions
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Donors Safety

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All potential living liver donors in the period from June 2010 to June 2012 Age between 18 and 50 years Relationship within 3rd degree of consanguinity with recipient or spouse. The donor-recipient pair must be blood group compatible. An informed consent should be obtained. Exclusion Criteria: Patients with nknown mrsdical or surgical history that interfere with donation Underlying medical condition (diabetes, cardiopulmonary disease, etc.). ABO incompatibility

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| causes of disqualification of potential Egyptian living liver-donors |  | 2 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Living donor liver transplantation, Donar safety