Remote Ischemic Preconditioning in Elective Percutaneous Interventions

Study Overview
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Brief Summary
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Myocardial injury occurs after percutaneous coronary intervention due to micro emboli, ischemia-reperfusion injury or side branch occlusion. 3 cycles of ischemic preconditioning has been shown to be useful in preventing myocardial injury but it is not suitable to perform it especially in ad hoc interventions. In this study the investigators aim is to show whether one cycle remote ischemic preconditioning will be enough to prevent myocardial injury during percutaneous coronary intervention.

Detailed Description
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About in one third of elective percutaneous coronary interventions (PCI) troponin release occurs showing myocardial necrosis. And it has been shown that myocardial necrosis due to coronary interventions has also adverse effects on long term prognosis. Beneficial effects of of ischemic preconditioning in elective PCI and in coronary artery bypass surgery has been shown in several studies. In most of the trials 3 cycles of ischemia was performed, but this is time consuming and it's not suitable to apply it, in ad-hoc interventions. The investigators found one study showing that one cycle will also be enough to prevent troponin elevation after elective PCI. The investigators aim was also to show that one cycle preconditioning performed just before coronary intervention will also be useful in preventing myocardial necrosis due to elective PCI.

Official Title
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Effect of One Cycle Remote Ischemic Preconditioning on Myocardial Injury After Percutaneous Coronary Interventions in Patients With Stable Coronary Artery Disease

Conditions
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Myocardial Ischemia, Ischemic Reperfusion Injury

Intervention / Treatment
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* Other: remote ischemic preconditioning


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria Patients with stable coronary artery disease, in whom percutaneous coronary intervention is planned after coronary angiography Patients with informed consent Exclusion Criteria: Acute or chronic renal failure (Creatinin clearance <60ml/dk) Acute heart failure Presence of hemodynamic instability Left main interventions Acute Coronary Syndrome Patients in whom cuff inflation is contraindicated in upper extremities (fistula, lymphoedema etc) Patients using nicorandil, glibenclamide or trimetazidine Patients not accepting the study Presence of troponin elevation before intervention Presence or suspicion of pregnancy

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Study group<br>Remote ischemic preconditioning arm Blood pressure cuff will be inflated up to 200 mmHg in the non-dominant arm for 5 minutes before guiding catheter engagement. | Other: remote ischemic preconditioning<br>* Blood pressure cuff inflation up to 200mmHg in the non-dominant arm before guiding catheter engagement<br>|
| No Intervention: Control group<br>No intervention will be performed. Percutaneous coronary intervention will be performed without ischemic preconditioning. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| hs-Troponin elevation |  | after 16 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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ischemic preconditioning, myocardial injury, percutaneous coronary intervention