Bortezomib, Combination Chemotherapy, and Rituximab as First-Line Therapy in Treating Patients With Stage III or Stage IV Follicular Non-Hodgkin's Lymphoma

Study Overview
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Brief Summary
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RATIONALE: Bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as cyclophosphamide, vincristine, and prednisone, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cancer-killing substances to them. Giving bortezomib together with combination chemotherapy and rituximab may kill more cancer cells. PURPOSE: This phase II trial is studying the side effects and how well giving bortezomib together with combination chemotherapy and rituximab works when given as first-line therapy in treating patients with stage III or stage IV follicular non-Hodgkin's lymphoma.

Detailed Description
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OBJECTIVES: Primary Assess the efficacy of systemic first-line treatment comprising bortezomib, cyclophosphamide, vincristine, prednisone, and rituximab, in terms of complete response rate, in patients with stage III or IV follicular non-Hodgkin's lymphoma. Assess the incidence of severe neurotoxicity (defined as grade 3 or 4 neuropathy or neuropathic pain during the first 4 courses of treatment) in patients treated with this regimen. Secondary Assess the overall response rate and response duration in patients treated with this regimen. Determine progression-free and overall survival of patients treated with this regimen. Evaluate the tolerability and characterize the toxicity profile of this regimen in these patients. Assess quality of life, with particular focus on neurotoxicity-related changes, of patients treated with this regimen. OUTLINE: This is a multicenter, nonrandomized, open-label study. Patient receive cyclophosphamide IV over 15-45 minutes, vincristine IV over 3-5 seconds and rituximab IV over 1½-6 hours on day 1, oral prednisone daily on days 1-5, and bortezomib IV over 3-5 seconds on days 1 and 8. Treatment repeats every 3 weeks for up to 8 courses in the absence of disease progression or unacceptable toxicity. Quality of life is assessed at baseline, at the end of each course of treatment, and on day 42 at the post treatment visit. After completion of study treatment, patients are followed at 3 and 6 weeks and then every 3-6 months thereafter. PROJECTED ACCRUAL: A total of 90 patients will be accrued for this study.

Official Title
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A Multi-Centre Phase II Trial Investigating the Efficacy and Tolerability of Bortezomib Added to Cyclophosphamide, Vincristine, Prednisone, and Rituximab (BCVP-R) for Patients With Advanced Stage Follicular Non-Hodgkin's Lymphoma Requiring Systemic First-Line Treatment

Conditions
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Lymphoma

Intervention / Treatment
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* Biological: rituximab
* Drug: bortezomib
* Drug: cyclophosphamide
* Drug: prednisone
* Drug: vincristine sulfate


Participation Criteria
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Eligibility Criteria
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DISEASE CHARACTERISTICS: Histologically confirmed follicular non-Hodgkin's lymphoma meeting the following criteria: Stage III or IV disease Grade 1, 2, or 3 disease requiring systemic first-line treatment No transformation to diffuse large cell lymphoma At least 1 bidimensionally measurable lesion meeting 1 of the following criteria: Lymph nodes > 1.5 cm x 1.0 cm by physical exam or CT scan Other non-nodal lesion ≥ 1.0 cm x 1.0 cm by MRI or CT scan OR ≥ 1.0 cm x 1.0 cm (e.g., skin lesions or nodules) by physical exam Must have a medical indication for treatment, as indicated by 1 of the following: Presence of constitutional symptoms that are attributed to lymphoma (e.g., B symptoms, including night sweats, fever, weight loss, fatigue, or pain) Lymphadenopathy that requires treatment based on presence of associated symptoms, potential threat to organ function (e.g., ureteric compromise from retroperitoneal disease), or degree of enlargement (i.e., > 5 cm) Impairment of normal organ function (e.g., impaired hematopoiesis due to marrow involvement by lymphoma or from splenomegaly and hypersplenism) Immune-related complications of lymphoma that require therapy Rate of disease progression for which observation is deemed inappropriate No history of any other lymphoproliferative disorder or evidence of transformation to an aggressive histology lymphoma No known CNS involvement by lymphoma PATIENT CHARACTERISTICS: ECOG performance status 0-2 Life expectancy ≥ 12 weeks Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception Platelet count ≥ 75,000/mm^3* Absolute neutrophil count ≥ 1,000/mm^3* Creatinine ≤ 1.5 times upper limit of normal (ULN) Bilirubin ≤ 1.5 times ULN AST or ALT ≤ 2.5 times ULN (5 times ULN if liver involvement with lymphoma) Able (i.e., sufficiently fluent) and willing to complete the quality of life questionnaires in either English or French Inability (illiteracy in English or French, loss of sight, or other equivalent reason) to complete the questionnaires will not make the patient ineligible for the study No history of other malignancies, except for the following: Adequately treated nonmelanoma skin cancer Curatively treated in situ cancer of the cervix Ductal carcinoma in situ of the breast (as long as radiation limitation is not exceeded) Other solid tumors curatively treated with no evidence of disease for > 5 years No history of allergic reactions attributed to compounds containing boron or mannitol No history of an unusual or severe allergic reaction to rituximab or similar agent No pre-existing neuropathy ≥ grade 2 No known HIV infection No other serious illness or medical condition that would preclude study participation, including any of the following: Active, uncontrolled bacterial, fungal, or viral infection Significant cardiac dysfunction Cardiovascular disease NOTE: *Exceptions will be allowed for values below these thresholds in patients with marrow involvement by lymphoma or lymphoma-related hypersplenism PRIOR CONCURRENT THERAPY: No prior systemic therapy for lymphoma No prior bortezomib, cyclophosphamide, or vincristine At least 4 weeks since prior radiotherapy that involved ≤ 25% of functioning bone marrow and recovered Exceptions may be made for low-dose, nonmyelosuppressive radiotherapy or if the irradiated field is not a significant marrow-bearing area At least 2 weeks since prior major surgery No other concurrent anticancer therapy, investigational agents, corticosteroids (except for physiologic replacement or antiemesis), cytotoxic chemotherapy, or immunotherapy

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 120 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Bortezomib + BCVP-R<br>BCVP-R - q 21 days x 4 cycles Bortezomib: 1.3 mg/m2 Days 1 & 8 Cyclophosphamide: 750 mg/m2 IV Day 1 Vincristine: 1.4 mg/m2 IV Day 1 (dose capped at 2 mg) Prednisone: 40 mg/m2 po Days 1-5 Rituximab: 375 mg/m2 IV Day 1 | Biological: rituximab<br>* 375mg/m2 day 1<br>Drug: bortezomib<br>* 1.3mg/m2 days 1 & 8<br>Drug: cyclophosphamide<br>* 750mg/m2 day 1<br>Drug: prednisone<br>* 40mg/m2 days 1-5<br>Drug: vincristine sulfate<br>* 1.4mg/m2 day 1 (dose capped at 2mg)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Complete response rate |  | 5 years | 
| Incidence of severe grade 3 or 4 neurotoxicity or neuropathic pain during the first 4 courses of treatment |  | 5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overall response rate |  | 5 years | 
| Response duration in patients with observed responses |  | 5 years | 
| Time to progression |  | 5 years | 
| Overall survival |  | 5 years | 
| Toxicity |  | 5 years | 
| Quality of life |  | 5 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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stage III grade 1 follicular lymphoma, stage III grade 2 follicular lymphoma, stage III grade 3 follicular lymphoma, stage IV grade 1 follicular lymphoma, stage IV grade 2 follicular lymphoma, stage IV grade 3 follicular lymphoma