The Next Leap in Cardiac Magnetic Resonance Imaging:Cycling the Field

Study Overview
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Brief Summary
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The main aim of the study is to build and test a cardiac-specific coil purposely assembled in house to suit the FFC-MRI whole-body prototype and to test if it could be used for clinical cardiac scans in human subject populations.

Detailed Description
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Aberdeen scientists are at the forefront of a new type of magnetic resonance imaging (MRI), having built in-house the only two available prototypes of Fast Field-Cycling MRI in the world - and these already have clinical imaging capabilities. Fast Field-Cycling MRI switches rapidly over a range of field strengths (0.2 T to 200 µT), providing a T1 dispersion curve. This information is invisible to fixed-field scanners and uncovers unique knowledge about motion and interaction between component molecules within a tissue (i.e. water/fat/proteins). In this application the investigators wish to use their in-house expertise further to extend the capability of our Fast Field-Cycling MRI to perform cardiac imaging by building the first-ever cardiac Fast Field-Cycling MRI coil and develop cardiac pulse sequences with ECG gating. The investigators will aim to establish the normalcy of T1 dispersion curves for left ventricular myocardium in healthy volunteers, and further on to distinguish the characteristics of post-myocardial infarction scar T1 dispersion curves.

Official Title
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The Next Leap in Cardiac Magnetic Resonance Imaging:Cycling the Field The TITAN Study

Conditions
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Myocardial Infarction

Intervention / Treatment
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* Procedure: Cardiac Magnetic Resonance Imaging
* Procedure: Fast Field Cycling - Magnetic Resonance Imaging
* Procedure: Electrocardiogram
* Procedure: Echocardiogram


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Participant who is willing and able to give informed consent for participation in the study Healthy volunteers willing to give informed consent for participation in the study Patients diagnosed with a previous myocardial infarction Exclusion Criteria: Unwillingness to participate Claustrophobia Contraindication to MRI scanning such as implantable cardiac devices Participants who have had a previous myocardial infarction in the past of which they may not be aware and this is discovered whilst being scanned on the 3T MRI scanner, or who may have any other cardiology condition that they were previously unaware will not be included in the healthy control group, even if they present themselves to us as healthy at the time of the study visit Pregnancy Body habitus that may preclude comfortable positioning of the volunteer in either of the MRI scanners (>50cm in diameter) Participants with abnormal kidney function that will preclude them from receiving a contrast agent

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: The main aim of the study is to build and test a cardiac-specific coil purposely assembled in house to suit the FFC-MRI whole-body prototype and to test if it could be used for clinical cardiac scans in human subject populations.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Myocardial Infarction Group<br>Patients diagnosed with a myocardial infarction | Procedure: Cardiac Magnetic Resonance Imaging<br>* Cardiac Magnetic Resonance Imaging - Cardiac Scan<br>Procedure: Fast Field Cycling - Magnetic Resonance Imaging<br>* Fast Field Cycling - Magnetic Resonance Imaging Cardiac Scan<br>|
| Experimental: Healthy Volunteers<br>Healthy Volunteers | Procedure: Cardiac Magnetic Resonance Imaging<br>* Cardiac Magnetic Resonance Imaging - Cardiac Scan<br>Procedure: Fast Field Cycling - Magnetic Resonance Imaging<br>* Fast Field Cycling - Magnetic Resonance Imaging Cardiac Scan<br>Procedure: Electrocardiogram<br>* Electrocardiogram<br>* Other names: ECG;Procedure: Echocardiogram<br>* Echocardiogram<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cardiac Magnetic Resonance Imaging | Cardiac Magnetic Resonance Imaging - Cardiac Scan to assess cardiac function and T1 dispersion curves | At baseline | 
| Fast Field Cycling Magnetic Resonance Imaging | Fast Field Cycling Magnetic Resonance Imaging - Cardiac Scan to assess cardiac function and T1 dispersion curves | At baseline |