linjc16/ctgov huggingface dataset:
The Effects of a Standardized Management Plan on Children With Critical Asthma

Study Overview
=================
Brief Summary
-----------------
A Standardized Clinical Assessment Management Plan (SCAMP) has been developed and implemented at Boston Children Hospital to decrease variations in clinical practice in critical asthma therapies for children. The primary aim is to determine whether a Critical Asthma SCAMP can improve clinical outcome.

Detailed Description
-----------------
A Standardized Clinical Assessment Management Plan (SCAMP) has been developed and implemented at Boston Children Hospital to decrease variations in clinical practice in critical asthma therapies for children. However the effects of the Critical Asthma SCAMP on the clinical outcomes in children with critical asthma are unknown. This study will assess the effectiveness of the SCAMP by comparing retrospective data from medical records in children with critical asthma to prospective clinical PPSQ SCAMP outcome data obtained during the QA process of the SCAMP. The primary aim is to determine whether a Critical Asthma SCAMP can improve clinical outcome. There are three specific pathways in the Critical Asthma SCAMP. The primary outcome measure is the length of intensive care length of stay (defined as time to every 2 hr intermittent albuterol nebulization) for all three pathways. The secondary aim is to validate a clinical asthma score to direct critical asthma therapies. To achieve this goal we will determine the relationships of the driver(s) of the SCAMP which includes Boston Children Hospital (BCH) Asthma Severity Score [HASS] and non-invasive measures of pCO2 to standard measures of severity of asthma (blood gases and peak flow measurements).

Official Title
-----------------
The Effects of a Standardized Clinical Assessment Management Plan (SCAMP) on Clinical Outcomes in Children With Critical Asthma

Conditions
-----------------
Children, Asthma

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Hospitalized patients 2 years and older requiring critical asthma therapies including continuous albuterol nebulization

Ages Eligible for Study
-----------------
Minimum Age: 2 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Chidren with critical asthma<br>Pre- and post-SCAMP | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time from initialization of continuous albuterol to time of final every 2 hr albuterol nebulization |  | The time to intermittent q2 hr albuterol nebulization from continuous albuterol during hospitalization within 30 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
critical, children, asthma
Review of French Cases of Glutathione Synthetase Deficiency

Study Overview
=================
Brief Summary
-----------------
The glutathione synthetase deficiency, inborn error of metabolism of autosomal recessive inheritance, is a rare disease (70 patients described in the world). The outcome of these patients and potential complications of this disease are not, to date, yet all known and described.

Conditions
-----------------
The Glutathione Synthetase Deficiency

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: All patients followed in the French hospital centers the diagnosis of glutathione synthetase deficiency has been proven by assay of residual enzyme activity or identifying a mutation of the glutathione synthetase gene Exclusion criteria: No formal proof of glutathione synthetase deficiency

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Immunologically determining human acid glutathione S-transferase in a human assay sample |  | 1 hour after hospitalization | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
recessive, glutathione, glutathione synthetase deficiency, autosomal inheritance
Follow up Study of Patients Undergoing Total Hip Arthroplasty CERAFIT® Grafted With Poly Sodium Styrene Sulfonate

Study Overview
=================
Brief Summary
-----------------
The risk of infection after primary Total Hip Arthroplasties (THA)is generally estimated to be less than 1% but remains a severe and costly complication, source of morbidity and even mortality. The biofilm forms very early after the bacterial contamination of the prosthesis and poses a number of clinical challenges due to his resistance to immune defence mechanisms and antibiotics. Preventive strategies are needed. The poly sodium styrene sulfonate (pNaSS) is a bioactive polymer. In vitro and in vivo studies showed that poly sodium styrene sulfonate grafted on titane surfaces reduce significantly the bacterial adhesion. They also proved his biocompatibility and osseous-integration.

Official Title
-----------------
Follow up Study of Patients Undergoing Total Hip Arthroplasty CERAFIT® Grafted With Poly Sodium Styrene Sulfonate

Conditions
-----------------
Hip Arthroplasty Replacement

Intervention / Treatment
-----------------
* Procedure: Total Hip Arthroplasty Replacement


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age less than 75 years old Aetiologies for THA : primary osteoarthritis, inflammatory diseases,Osteonecrosis Exclusion Criteria: Previous infectious hip arthritis Previous surgeries on the operated hip Revision of THA

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Total Hip Arthroplasty CERAFIT® grafted<br> | Procedure: Total Hip Arthroplasty Replacement<br>* Total Hip Arthroplasty Replacement<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Femoral component osseous-integration | Scoring system of Engh | 1 year after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Infection rate | Infection (yes/no) : Clinical, biological or radiological THA infection signs. In the case of infection suspicion, hip aspiration will be performed with joint fluid culture | 1 year after surgery | 
| Quality of Life | SF-36 score | One, three, six and twelve months after surgery | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Total Hip arthroplasty, Hip Osteoarthritis, Infection after Total Hip Arthroplasty
Detecting Urinary Retention After Child Birth With a Ultrasound Scanner

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is a systematical registration of ultrasound measurements and urinary volume after catheterization. Based on these pairs of measurements we will calculate the reliability of ultrasound compared with catheter volume.

Official Title
-----------------
Detecting Urinary Retention After Child Birth With a Ultrasound Scanner

Conditions
-----------------
Urinary Retention

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Women with suspected urinary retention

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Urinary retention, Child birth, Catheterization, Ultrasound
A Dissemination Trial of the Positive Parenting Program to Reduce Child Maltreatment in South Carolina

Study Overview
=================
Brief Summary
-----------------
This is a population-based evaluation of the effectiveness of the Triple-P-Positive Parenting Program. Triple-P is a system of parenting programs with multiple levels that aims to provide parents with parenting skills and support.

Detailed Description
-----------------
Eighteen counties in the state of South Carolina will be randomized to the dissemination of the Triple-P system or to a waitlist control condition. University of South Carolina staff will train health care professionals in the nine dissemination counties to use the Triple-P parenting programs. Triple-P is a parenting program that uses a tiered system of interventions of increasing strength depending on parents' and children's differing needs, ranging from media and information-based strategies, to two levels of moderate-intensity intervention using a brief consultation format, to two more intensive levels of parent training and behavioral family intervention targeting parenting skills and other family adversity factors such as marital conflict, depression and high levels of parenting stress. The evaluation of the dissemination of Triple-P will rely on two methods: the analysis of aggregate data on child maltreatment, injuries and hospitalizations, and annual surveys of families to examining parenting education, practices, and child behavior.

Official Title
-----------------
A Dissemination Trial of the Positive Parenting Program to Reduce Child Maltreatment in South Carolina

Conditions
-----------------
Child Abuse

Intervention / Treatment
-----------------
* Behavioral: Positive Parenting Program (Triple-P)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Counties in South Carolina

Ages Eligible for Study
-----------------
Maximum Age: 7 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Factorial Assignment


Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: Positive Parenting Program (Triple-P)|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| child maltreatment reports |  |  | 
| injury to children |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
child maltreatment, child abuse, prevention
The Relationship Between Driving Pressure, Mechanical Power, Oxygenation and Saturation Indices: Retrospective Observational Study

Study Overview
=================
Brief Summary
-----------------
By using Mechanical Power and Driving Pressure instead of Pmean we calculate new oxygen saturation indices like Driving Pressure Oxygen Index (OIDP), Dynamic Power Oxygen Index (OIMPdyn), Total Power Oxygen Index (OIMPtot), Driving Pressure Saturation Index (OSIDP), Dynamic Power Saturation Index (OSIMPdyn) ve Power Saturation Index (OSIMPtot). New oxygenation and saturation indices are able to predict ICU mortality better than the conventional indexes and rates.

Official Title
-----------------
The Relationship Between Driving Pressure, Mechanical Power, Oxygenation and Saturation Indices: Retrospective Observational Study

Conditions
-----------------
Acute Respiratory Distress Syndrome, Pneumonia

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: - Patients with a diagnosis of Covid-19 related Acute Respiratory Syndrome (C-ARDS) which hospitalized in Bakirköy Dr. Sadi Konuk Training and Research Hospital intensive care unit Exclusion Criteria: Patients who did not receive invasive mechanical ventilation support. Patients who stayed in the intensive care unit for less than 24 hours. Patients with missing data Patients who received mechanical ventilation support for less than 24 hours Patients with Chronic Obstructive Pulmonary Disease (COPD). Patients with congestive heart failure Patients who underwent tube thoracostomy due to tension pneumothorax Patients who received Extracorporeal Membrane Oxygenation (ECMO) support

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| In hospital mortality | we estimate hospital mortality mortality by calculating new oxygenation index | 28 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mechanical ventilatory free days | we estimate hospital mortality mortality by calculating new saturation index | 30 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
acute respiratory distress syndrome, pneumonia, oxygenation index, saturation index
Effect of Lumbo-sacral Magnetic Stimulation on Colonic Motility

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate the effect of sacral nerve magnetic stimulation on the colonic motility in healthy subjects, in incontinent and constipated patients.

Official Title
-----------------
Could Lumbo-sacral Magnetic Stimulation Modify Recto-colonic Motility?

Conditions
-----------------
Functional Colonic Disease, Fecal Incontinence

Intervention / Treatment
-----------------
* Procedure: lombo-sacral magnetic stimulation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: healthy volunteers Exclusion Criteria: pregnant women metallic material implanted organic digestive disease neuro-surgery

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: lombo-sacral magnetic stimulation|repetitive lombo-sacral nerve magnetic stimulation active and placebo performed during colonic recordings after bisacodyl instillation|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
sacral magnetic stimulation, fecal incontinence, constipation
Frequency of Patho-morphological Classes of Gall Stones in Lahore, Pakistan

Study Overview
=================
Brief Summary
-----------------
It is a cross sectional study in which we are tying to determine frequency of type of gall stones in our setup(Lahore, Pakistan).

Official Title
-----------------
Frequency of Patho-morphological Classes of Gall Stones in Lahore, Pakistan

Conditions
-----------------
Gallstone

Intervention / Treatment
-----------------
* Diagnostic Test: Biochemistry of gall stones


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with any sex age 1 5 years and above presenting to OPD with cholelithiasis - Exclusion Criteria: patients who develop gallstones after bariatric surgery less than 15 years of age

Ages Eligible for Study
-----------------
Minimum Age: 15 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: Biochemistry of gall stones|Analysis of gallstones is done to determine the biochemical types of gallstone like cholesterol stone, pigmented stones or mix stones|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Frequency of type of gallstones | primay outcome is to determine the frequency of biochemical classes of gallstones in lahore | 1 week |
Depression and Cardiovascular Risk Markers: Effects of Rosuvastatin Therapy

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to investigate whether rosuvastatin decreases measures of inflammation in depressive patients.

Detailed Description
-----------------
Depression is associated with increased risk of cardiovascular disease, in which one possible mechanism is systemic inflammation. Further, patients at high risk of cardiovascular disease, rosuvastatin decreases the risk, especially among patients with increased inflammation. This is a proof-of-concept study to investigate whether the antiinflammatory effect of rosuvastatin is similar in depressive as in patients with cardiovascular disease.

Official Title
-----------------
Depression and Cardiovascular Risk Markers: Effects of Rosuvastatin Therapy

Conditions
-----------------
Depression

Intervention / Treatment
-----------------
* Drug: rosuvastatin
* Drug: Placebo


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Persisting self-reported depressive symptoms > 5 weeks Indications of aortic atherosclerosis on PET/CT Exclusion Criteria: Clinical indication of statin use. Contraindication of statins, or of PET/CT and MRI. Established cardiovascular disease. Bipolar disorder og comorbid psychosis.

Ages Eligible for Study
-----------------
Minimum Age: 40 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 2<br>Rosuvastatin | Drug: rosuvastatin<br>* 10mg tablets, once daily in three months<br>|
| Placebo Comparator: 1<br>Placebo | Drug: Placebo<br>* tablet, once daily, three months<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mean SUV of large arteries |  | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Peripheral endothelial function (pulse wave amplitude) |  | 3 months | 
| Circulatory proinflammatory markers |  | 3 months | 
| Heart rate variability |  | 3 months | 
| Depressive symptoms |  | 3 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Inflammation, Atherosclerosis, Hydroxymethylglutaryl-CoA Reductase Inhibitors
Calibration and Validation of the STISIM Driving Simulator

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to calibrate the STISIM driving simulator under influence of three different dosages of ethanol (0.05%, 0.08% and 0.11% BAC). The levels of performance decrement for the three blood alcohol concentrations will serve as a standard for comparing the effects that will be observed with psychoactive drugs in future trials. This will make the results of these future studies more easily to interpret and will provide health care providers and policy makers who read our scientific work with an easy-to-understand and clinically relevant comparison.

Official Title
-----------------
Calibration and Validation of the STISIM Driving Simulator: Simulated Driving Performance Under the Influence of Alcohol (0.05%, 0.08% AND 0.11%), and Placebo

Conditions
-----------------
Simulated Driving Performance

Intervention / Treatment
-----------------
* Other: alcohol


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 21-50 years old Written informed consent Normal static binocular acuity, corrected or uncorrected Normal hearing Social Drinker (average of 7 to 21 alcoholic drinks per week and experience with drinking 4-6 drinks per occasion) No current or past drug use Possession of a driver's license for at least 3 years Be considered as reliable and mentally capable of adhering to the protocol Exclusion Criteria: Current and past drug use (positive urine drug screen on the presence of amphetamines (including MDMA), barbiturates, cannabinoids, benzodiazepines, cocaine, and opiates) Positive urine pregnancy screen in women Present use of psychoactive medication Positive alcohol breath test Prior enrollment in the same study Physical or mental illness Excessive alcohol use ( > 21 alcoholic drinks per week) Excessive smoking (more than 10 cigarettes per day) Intake of caffeine-containing beverages over 5 glasses per day Simulator sickness, as determined during the training session

Ages Eligible for Study
-----------------
Minimum Age: 21 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: alcohol|alcohol 0.05%, 0.08% or 0.11% or placebo|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Standard Deviation of the Lateral Position (SDLP) |  | one day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of collisions and traffic violations |  | 20 minutes | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
STISIM, Alcohol