CCTA Improves Clinical Management of Stable Chest Pain

Study Overview
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Brief Summary
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The investigator aims to prospectively enroll patients who were referred for coronary computed tomography angiography (CCTA) for the assessment of stable chest pain (SCP) suspected of obstructive coronary artery disease (CAD). All patients underwent CCTA according to established guidelines and local institutional protocols. The imaging data were evaluated using different image post-processing software to comprehensively analyse anatomical, functional and histological information of coronary. This study will determine if CCTA-based imaging evaluation can provide more informaton to improve clinical management for SCP, including fewer MACE and better decision-making of downstream investigations and therapeutic interventions.

Official Title
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Improving the Clinical Management of Stable Chest Pain Based on Imaging: a Registry of Computed Tomography Coronary Angiography

Conditions
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Optimal Medical Therapy, Invasive Coronary Angiography, Revascularization, Major Adverse Cardiovascular Events, Coronary Computed Tomography Angiography, Stable Chest Pain, Coronary Artery Disease

Intervention / Treatment
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* Diagnostic Test: CCTA


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: symptomatic patients with SCP suspected of obstructive CAD. referred for CCTA for the assessment of SCP. ≥18 years of age. signed informed consent. Exclusion Criteria: acute coronary syndromes, previous CAD or coronary revascularization nonsinus rhythm cardiomyopathy, valvular disease, congenital heart disease or left cardiac insufficiency because of other reasons missing data

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| CCTA<br> | Diagnostic Test: CCTA<br>* All patients underwent CCTA according to established guidelines and local institutional protocols. The imaging data were evaluated using different image post-processing software to comprehensively analyse anatomical, functional and histological information of coronary.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Major adverse cardiovascular events | Cardiac death and myocardial infarction | 3 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Invasive coronary angiography | Invasive coronary angiography occurred at follow-up after CCTA, attributed to CCTA results or unplanned. | 3 years | 
| Medication prescription | Change for medication prescription of antiplatelet agents, anti-ischemic drugs, lipid-lowering agents, angiotensin-converting enzyme inhibition and so on, attributed to CCTA results or unplanned, | 3 years | 
| Coronary revascularization | PTCA, PCI or CABG occurred at follow-up after CCTA, attributed to CCTA results or unplanned. | 3 years |