Gastric Slow Wave and Autonomic Nervous Function in Cirrhotic Patients With Esophageal Varices After Ligation-A Clinical Research

Study Overview
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Brief Summary
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This study is intended to include 20 patients with esophageal varices caused by liver cirrhosis who were admitted to the first affiliated hospital of nanjing medical university from May 2019, and randomly select 8 patients with gastric polyps as the control group.General clinical data, imaging data, endoscopic data and laboratory indicators were collected.Electrogastrogram (EGG) and Heart Rate Variability (HRV) were performed before and 24 hours after operation in patients with cirrhotic esophageal varices, and the dyspepsia scale was filled out.Electrogastrogram (EGG) and cardiac variability (HRV) were performed in patients with gastric polyps 24 hours before and after surgery, and the dyspepsia scale was filled.EGG uses the surface electrode to record gastric myoelectric activity, and evaluates the patient's gastric rhythm by normal slow wave ratio, overspeed ratio, overslow ratio, and rhythm disorder ratio.The HRV evaluates the balance state of the patient's autonomic nervous system with High Frequency (HF)/Low Frequency (LF).SPSS software was used for paired sample analysis of experimental results.

Official Title
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Gastric Slow Wave and Autonomic Nervous Function in Cirrhotic Patients With

Conditions
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Esophageal Varices in Cirrhosis of the Liver

Intervention / Treatment
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* Diagnostic Test: Electrogastrogram(EGG)
* Diagnostic Test: Heart Rate Variability(HRV)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients over 18 years old with cirrhosis of esophageal varices who underwent endoscopic ligation Signed informed consent Exclusion Criteria: Hemorrhage in the digestive tract, unstable vital signs Hepatic encephalopathy Unwilling to cooperate with the examiner Skin allergies

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with cirrhosis of esophageal varices<br> | Diagnostic Test: Electrogastrogram(EGG)<br>* Heart Rate Variability<br>Diagnostic Test: Heart Rate Variability(HRV)<br>* Heart Rate Variability<br>|
| Patients with gastric polyps<br> | Diagnostic Test: Electrogastrogram(EGG)<br>* Heart Rate Variability<br>Diagnostic Test: Heart Rate Variability(HRV)<br>* Heart Rate Variability<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Gastric Slow Wave of patients before the surgery, Change from Baseline Gastric Slow Wave 1 day after the surgery ,Change from Baseline Gastric Slow Wave 5 days after the surgery | EGG evaluate patient's gastric electrical rhythm by normal slow wave ratio, overspeed ratio, overslow ratio, and rhythm disorder ratio Evaluating patient's gastric electrical rhythm by normal slow wave ratio, overspeed ratio, overslow ratio, and rhythm disorder ratio Evaluating patient's gastric electrical rhythm by normal slow wave ratio, overspeed ratio, overslow ratio, and rhythm disorder ratio Evaluating patient's gastric electrical rhythm by normal slow wave ratio, overspeed ratio, overslow ratio, and rhythm disorder ratio | before the surgery, 1 day after the surgery, and 5 days after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| LF/HF of patients before the surgery, Change from Baseline LF/HF 1 day after the surgery ,Change from Baseline LF/HF 5 days after the surgery | HRV assesses the balance of the patient's autonomic nervous system with high frequency (HF) / low frequency (LF) | before the surgery, 1 day afterthe surgery, and 5 days after surgery |