Evaluation of Metabolism-Boosting Beverages

Study Overview
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Brief Summary
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The purpose of this study is to assess the effect of Metabolism-boosting Beverages (MBB) containing green tea extract with a standardized amount of epigallocatechin gallate (EGCG) and caffeine.

Detailed Description
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The study will assess the effect of MBB's on 24 hour energy expenditure by performing indirect calorimetry, and on appetite using visual analogue scales (VAS). The planned sample size is 54 healthy male and female adults, both lean and overweight. We plan to test 6 metabolism-boosting beverages in the following order: 1) Raspberry Tea 2) Banana Shake 3) Chai Latte 4) Strawberry Shake 5) Cappuccino 6) Hot Cocoa. In the order that they are screened, each subject will be assigned to receive 1 of 6 Metabolism-boosting beverages. Each MBB will contain 90 mg EGCG and 100 mg caffeine.

Official Title
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The Effect of Metabolism-Boosting Beverages on 24 Hr Energy Expenditure

Conditions
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Energy Expenditure, Appetite

Intervention / Treatment
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* Other: Medifast Metabolism-boosting Beverages


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adult males and females (age between 18 and 65) BMI ≥18.5 - ≤ 40.0 kg/m2 Non-smokers No known food allergies to wheat, gluten, soy or nuts ≤ 14 alcoholic beverages per week No sensitivity to caffeine or green tea No alcohol or caffeine on days when metabolism is tested Willing and able to give informed consent Not currently using appetite-affecting medications (e.g SSRIs, steroids, Ritalin) Not pregnant or lactating Exclusion Criteria: Actively dieting Chronic uncontrolled health problems (not including obesity or controlled: type-2 diabetes, hyperlipidemia, hypertension) History of arrhythmia, or taking anti-arrhythmic medications (e.g. propafenone) Schizophrenia, history of bipolar disorder, current Major Depressive Disorder Dependence on alcohol or sedative-hypnotic drugs (e.g. benzodiazepines) Cognitive impairment severe enough to preclude informed consent Taking weight loss or appetite-suppressant medications Taking appetite affecting medications (e.g. SSRIs, steroids, Ritalin) Food allergies to wheat, gluten, soy, or nuts Sensitivity to caffeine or green tea

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Medifast Metabolism-boosting Beverages|Medifast metabolism-boosting beverages containing 90 mg EGCG and 100 mg caffeine.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To assess the effect of MBBs on REE by performing indirect calorimetry |  | 30, 60, 90, and 120 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To assess the effect of MBBs on appetite via visual analogue scales |  | 30, 60, 90, and 120 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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obesity, metabolism, weight loss, energy expenditure, thermogenesis, Metabolism-Boosting Beverages effect on REE, Metabolism-Boosting Beverages effect on appetite