Risk Factors and the Role of Albumin-to-globulin Ratio in Idiopathic Granulomatous Mastitis

Study Overview
=================
Brief Summary
-----------------
Albumin-to-globulin ratio (AGR) is an inflammation-based index that has been shown to have a role in many cancers and inflammatory diseases. Idiopathic granulomatous mastitis (IGM) is a rare inflammatory disease of the breast with a high recurrence rate. As a relatively new biomarker for inflammatory diseases, AGR's role in IGM recurrence has never been investigated in the literature. This study primarily investigates the possible risk factors for IGM recurrence and whether AGR can be used as a predictive factor.

Detailed Description
-----------------
Patients diagnosed with IGM on pathology reports between January 2016 and March 2021 were enrolled in the study and their medical records were analyzed retrospectively. The patients were divided into two groups: recurrence and non-recurrence. Clinical, demographic characteristics, and laboratory parameters were compared. The best cut-off value for significant factors in predicting recurrence was determined by receiver operating characteristic (ROC) analysis. Univariate and multivariate logistic regression analysis was used to determine the risk factors that are effective in IGM recurrence.

Official Title
-----------------
Evaluating the Risk Factors and the Role of Albumin-to-globulin Ratio in Predicting Recurrence Among Patients With Idiopathic Granulomatous Mastitis

Conditions
-----------------
Idiopathic Granulomatous Mastitis

Intervention / Treatment
-----------------
* Procedure: segmental mastectomy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: The patients with a pathologically confirmed diagnosis of granulomatous mastitis Patients over the age of 18 Female patients Exclusion Criteria: Male patients Secondary granulomatous mastitis etiologies (tuberculous mastitis and Wegener's granulomatosis) Patients who do not have enough follow-up information Patients with missing data

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| no recurrence<br>Patients who recovered after IGM treatment and had no signs of relapse | Procedure: segmental mastectomy<br>* The preferred method in the treatment of some patients diagnosed with IGM<br>* Other names: Incision and Drainage;|
| recurrence<br>Patients whose symptoms reappear 3 months after IGM treatment | Procedure: segmental mastectomy<br>* The preferred method in the treatment of some patients diagnosed with IGM<br>* Other names: Incision and Drainage;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| IGM recurrence | Recurrence was defined as the reappearance of breast complaints such as pain, mass, abscess, and fistula at the end of at least three months following remission with treatment. IGM developed in the other breast after the treatment was also accepted as a recurrent case. | within an average of 3-4 years of follow-up after treatment | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Idiopathic granulomatous mastitis, recurrence, albumin-to-globulin ratio, risk factors