linjc16/ctgov huggingface dataset:
Elevated Serum HDL in Four Generations of a Nashville Family

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine the genetic basis of one family's hereditary hyper-HDL-emia using multiple modalities such as linkage analysis and gene array.

Detailed Description
-----------------
HDL, or good cholesterol, has been shown to protect against heart attack and stroke. How HDL works as a protective agent is not well understood. There is a family that has 4 generations of living members with high HDL level. In the study, after consent is obtained, we will obtain 2 tablespoons of blood from all the family members in order to study their cholesterol levels and to obtain DNA in order to determine if there is a pattern of inheritance for this trait. We will also have them fill out a questionnaire about their medical history, diet and activity level as all of these can affect their HDL levels. In addition we will obtain additional blood (about 2 tablespoons) for plasma, white blood cells and also perform a biopsy to obtain skin cells from a matched pair of family members with and without the trait in order to determine which genes might be turned on and off because of this trait. We also wish to study other families who have members with high HDL cholesterol as well. These individuals will be identified from a core database.

Official Title
-----------------
Elevated Serum HDL in Four Generations of a Nashville Family

Conditions
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Hyperlipidemias

Intervention / Treatment
-----------------
* Other: No Intervention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 26 living members of a family with HDL levels greater than 90mg/dl and several of whom will act as related age matched controls. The investigators will also identify individuals in a lipid core database with HDL's of greater than 90mg/dl who have normal or low LDL and triglyceride levels and determine if they have normal or low LDL and triglyceride levels and determine if they have family members (parents or siblings) who also have high HDL cholesterol. Exclusion Criteria: Individuals who are not a member of the study family and individuals with high HDL's and elevated LDL and/or triglycerides.

Ages Eligible for Study
-----------------
Minimum Age: 5 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>Single family cohort | Other: No Intervention<br>* No intervention<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
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Cholesterol, Hyperlipidemia, Gene array
Impact of Diet and/or Exercise-induced Weight Loss on Cardiovascular Risk Factors

Study Overview
=================
Brief Summary
-----------------
The purpose of this pilot study is to examine the effect of diet and/or exercise-induced weight loss on nontraditional cardiovascular risk factors such as c-reactive protein, insulin levels and sex steroids in obese postmenopausal women.

Official Title
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Longitudinal Impact of Diet and/or Exercise-induced Weight Loss on Metabolic Markers of Cardiovascular Disease

Conditions
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Cardiovascular Diseases

Intervention / Treatment
-----------------
* Behavioral: diet and/or exercise


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: obese postmenopausal women able to exercise non-smokers Exclusion Criteria: cardiovascular disease medications that would interfere with outcome measures (e.g., including ACE inhibitors, lipid lowering medications, beta-blockers, etc) known diabetes

Ages Eligible for Study
-----------------
Minimum Age: 40 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: 1<br>Diet alone | Behavioral: diet and/or exercise<br>* Three arms are included: Diet Alone, Exercise Alone, and Combined Diet and Exercise<br>|
| Active Comparator: 2<br>Exercise alone | Behavioral: diet and/or exercise<br>* Three arms are included: Diet Alone, Exercise Alone, and Combined Diet and Exercise<br>|
| Active Comparator: 3<br>Diet and exercise (combined) | Behavioral: diet and/or exercise<br>* Three arms are included: Diet Alone, Exercise Alone, and Combined Diet and Exercise<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| c-reactive protein |  | baseline, every 1-2 weeks during intervention , then end-of-study | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| HOMA (measure of insulin resistance) and sex steroids |  | baseline, every 1-2 weeks during intervention, then end-of-study | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
c-reactive protein, obesity, women's cardiovascular health
Prevalence and Factors Associated With Postoperative Hypothermia in Mulago Hospital

Study Overview
=================
Brief Summary
-----------------
Patient's sublingual temperature was measured postoperatively on entry to the recovery room.

Detailed Description
-----------------
Adult patients who underwent non-neurological and non-cardiac surgery had their sublingual temperature measured postoperatively on entry to the recovery room.

Official Title
-----------------
Prevalence and Factors Associated With Postoperative Hypothermia Among Patients Undergoing Anaesthesia and Surgery in Mulago National Referral Hospital

Conditions
-----------------
Post Operative Hypothermia

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All patients of 18 years and above, undergoing surgery and anaesthesia lasting longer than 30minutes. All patients of 18 years and above, undergoing elective and emergency non cardiac and non-neurological operations in Mulago National Referral Hospital. Exclusion Criteria: Patients with contraindications to measurement of sublingual temperature

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative hypothermia | Sublingual temperature at entry to the recovery room | July 2016 to February 2017 |
Treatment of Non-small Cell Lung Cancer With Cytokine-induced Killer (CIK) Cells Blocked by PD-1 Antibody

Study Overview
=================
Brief Summary
-----------------
to evaluate the prognosis of non-small cell lung carcinoma patients under CIK cellular treatment with PD-1 blocking on top of the standard therapy

Official Title
-----------------
Treatment of Non-small Cell Lung Cancer With CIK Cells Blocked by PD-1 Antibody

Conditions
-----------------
Non-small Cell Lung Cancer

Intervention / Treatment
-----------------
* Biological: CIK cells with PD-1 blocking
* Other: standard lung cancer treament
* Biological: CIK cells without PD-1 blocking


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: non-small cell lung cancer; more than 50% tumor tissues positive with PD-L1; EGFR and ALK wild type no other tumors Exclusion Criteria: with systematic diseases shortening survival

Ages Eligible for Study
-----------------
Minimum Age: 40 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: CIK cells with PD-1 blocking<br>CIK cellular therapy with PD-1 blocking combined with standard lung cancer treatment | Biological: CIK cells with PD-1 blocking<br>* CIK cellular therapy with PD-1 blocking<br>Other: standard lung cancer treament<br>* standard non-small cell lung cancer treatment: surgery, chemotherapy<br>|
| Active Comparator: CIK cells without PD-1 blocking<br>CIK cellular therapy without PD-1 blocking combined with the same standard lung cancer treatment as the experimental group patients receive | Other: standard lung cancer treament<br>* standard non-small cell lung cancer treatment: surgery, chemotherapy<br>Biological: CIK cells without PD-1 blocking<br>* CIK cellular therapy without PD-1 blocking<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| progression-free survival |  | 5 years | 
| metastasis-free survival |  | 5 years |
Identification of Predictive Factors for Survival of Patients With Recurrent Prostate Cancer From Clinical Features, Tissue Image Features and Molecular Biomarker Data

Study Overview
=================
Brief Summary
-----------------
We seek to improve the predictive accuracy of the nomogram to predict survival for patients with castrate mets disease through the addition of pathological data, the results of automated machine vision based image analysis of H&E stained tumor tissue developed at Aureon Biosciences,and molecular biomarker studies (25 markers) determined by immunohistochemistry on tissue microarrays prepared from paraffin-embedded tumor.

Official Title
-----------------
Identification of Predictive Factors for Survival of Patients With Recurrent Prostate Cancer From Clinical Features, Tissue Image Features and Molecular Biomarker Data

Conditions
-----------------
Prostate Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients in the first retrospective study (Stage 1) must be part of the 409 patient strong MSKCC cohort with progressive metastatic prostate cancer which was used for the generation of the original nomogram. For details please see original publication by Smaletz et al. Patients involved in the second retrospective study (Stage 2) must be part of the 223 patients with a rising PSA after surgery or radiation therapy who were treated on conjugate vaccine trials at MSKCC.. Exclusion Criteria: For details of excluded patients on the clinical metastases castrate disease study, please see original publication by Smaletz et al.4 • (MSKCC - add reference if publication available for rising PSA patients)
Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The analysis for the progressive castrate mets disease population consists of two analytical steps. The first step involved the development of a predictive model of pt survival using supervised multivariate analytical (SMA)techniques |  | 2 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
castration resistant prostate cancer, progressive castrate metastatic prostate cancer
Introduction of the ADAPT System in an Orthopedic Department

Study Overview
=================
Brief Summary
-----------------
The ADAPT system by Stryker is introduced in the orthopedic department (at Aarhus University Hospital). Following the introduction of the ADAPT system all pertrochanteric fractures operated with a gamma3 nail by stryker are operated with the use of the ADAPT system. Following surgery the operating surgeon fill out a questionaire on the use of ADAPT.

Detailed Description
-----------------
At the ortopedic department, Aarhus University Hospital pertrochanteric fractures are mostly operated with the gamma3 system by Stryker. The ADAPT system is software based instrumentation designed for use in Gamma3 surgery. The software assists the surgeon with implant alignment, lag screw length determination, lag screw positioning and distal targeting. ADAPT is the only augmented reality instrumentation of its kind. From March 1, 2021 it becomes mandatory for all orthopedic surgeons at the department to use the ADAPT system when operating pertrochanteric fractures with a gamma3 nail. Following surgery the operating surgeon will fill out the System Usability Scale questionaire and an additional 3 questions.

Official Title
-----------------
Introduction of the ADAPT System for Pertrochanteric Fractures in an Orthopedic Department

Conditions
-----------------
Pertrochanteric Fracture

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Surgeons who operated patients with pertrochanteric fractures with the use of a gamma3 nail Exclusion Criteria: none
Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| ADAPT<br>The ADAPT system by Striker | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| System Usability Scale | Result of the System Usability Scale questionaire. The System Usability Scale is a questionaire that include 10 questions that participans rank from 1 to 5 (5 means they agree completely, 1 that they disagreee). Highest score is 100 due to the calculation process. Above 80.3 means that the participans are finding ADAPT very usefull and will recommend the use of the system to collegeaus, Above 68 means that participans finds ADAPT usefull, Below 51 means participans finds ADAPT unusefull. | Questionaire including the system usability scale will be send to surgeons within 24 hours following surgery |
Gilles de la Tourette Syndrome (TS) and Seasonality

Study Overview
=================
Brief Summary
-----------------
This retrospective and prospective observational study intends to evaluate the correlation between seasons and the variation of the syndromic structure of the Tourette.

Official Title
-----------------
Gilles de la Tourette Syndrome (TS) and Seasonality: a Pilot Study

Conditions
-----------------
Tourette Syndrome

Intervention / Treatment
-----------------
* Other: Administration of questionnaires


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients attending the Tourette Center since January 2012. Males and females. Age between 6 and 50 (completed). Diagnosis of Tourette syndrome ascertained Presence of a value equal to or greater than 15/40 of the Y-BOCS. Exclusion Criteria: Presence of allergic pathology. Presence of significant psychiatric symptoms, with the exception of those belonging to the Tourette Syndrome itself (eg ADHD, OCD)

Ages Eligible for Study
-----------------
Minimum Age: 6 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Administration of questionnaires|According to clinical practice, the following questionnaires are administered: Y-GTSS Y-BOCS or cY-BOCS|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from baseline Y-GTSS score at 6 months. | The primary objective is to investigate the correlation between seasons and different phenotypic variation through the administration of a specific questionnaire (Y-GTSS) and questions about the subjective perception of the ticcogenic variation. | 4, 8, 12 months. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from baseline Y-BOCS score at 6 months. | Secondary objective is to investigate the correlation between seasons and variation of severity of obsessive-compulsive disorder (OCD) through the administration of Y-BOCS, a questionnaire indicated to evaluate the severity of obsessive-compulsive disorder. | 4, 8, 12 months. |
The Impact of Covid 19 Pandemic on the Training of General Surgery Residents

Study Overview
=================
Brief Summary
-----------------
The educational process of general surgery residents is a very important step in every surgeon's career, which is often overlooked or neglected. The Covid-19 pandemic has inflicted deep changes in the medical activity in general and in the training process of young doctors in particular. Our study aims to assess the impact of the Covid-19 pandemic on the educational process of general surgery residents, through a comparative study. The responses of resident doctors at a questionnaire, in two different time periods, will be compared: pre-Covid era (December 2019) and Covid era (December 2020).

Official Title
-----------------
The Impact of Covid 19 Pandemic on the Training of General Surgery Residents

Conditions
-----------------
COVID-19 Pandemic, Educational Problems

Intervention / Treatment
-----------------
* Other: Training in surgery


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: General surgery residents Above second year of residency Residency program in Cluj-Napoca Medical Centre Exclusion Criteria: Incomplete responses to the questionnaire Refusal to be included in the study

Ages Eligible for Study
-----------------
Minimum Age: 20 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| pre-Covid era<br> | Other: Training in surgery<br>* The study evaluates the training process of general surgery residents - in classic surgery, as well as laparoscopic surgery, from hospital activity to extracurricular activities.<br>|
| Covid-era<br> | Other: Training in surgery<br>* The study evaluates the training process of general surgery residents - in classic surgery, as well as laparoscopic surgery, from hospital activity to extracurricular activities.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The impact of the pandemic on the educational process | Active participation in the operating room (hours/day, day/week), Theoretical education (hours/week), possibilities of extracurricular training | December 2019-December 2020 |
Planning Margin Requirements for Pediatric Radiation Oncology

Study Overview
=================
Brief Summary
-----------------
The planning target volume (PTV) and planning organ at risk volume (PRV) margins used for pediatric radiation therapy are empiric, and quantitative assessment of these margins is needed to improve therapy planning and delivery.

Detailed Description
-----------------
Data will be gathered to develop a model to quantify the setup margin (SM) portion of the planning target volume (PTV) margin for pediatric tumor sites according to age, localization technique, treatment position, and the use of general anesthesia. Patient specific PTV and PRV margin recommendations will be developed based on the number of participants.

Official Title
-----------------
Planning Margin Requirements for Pediatric Radiation Oncology

Conditions
-----------------
Pediatric Radiation

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients will receive conformal or intensity-modulated radiation therapy (3D or IMRT). Research participant or legal guardian/representative gives written informed consent. Exclusion Criteria: Unwillingness of research participant or legal guardian/representative to give written informed consent
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Acquire data to develop setup margin (SM) portion of the planning target volume (PTV) margin for pediatric tumor sites according to age, localization technique, treatment position, and the use of general anesthesia. |  | 4 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Estimate the number of patients required to develop a patient specific PTV and RTV margin recommendations. |  | 4 year |