Neural Bases of Post-stroke Emotion Perception Disorders

Study Overview
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Brief Summary
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This monocentric physiological study will evaluate the neural bases of visual recognition of emotions in stroke patients vs. healthy controls using MRI (functional and structural connectivity) and EEG.

Detailed Description
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This monocentric physiological study will evaluate the neural bases of visual recognition of emotions in stroke patients vs healthy controls (2 groups of 40 subjects). It will include functional MRI, structural MRI (disconnectome), EEG, and behavioral assessments of emotion recognition and executive functions.

Official Title
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Neural Bases of Post-stroke Emotion Perception Disorders

Conditions
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Stroke, Stroke Sequelae, Emotions

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Stroke group: Man or Woman Age 18-80y Unique stroke, ischemic or hemorrhagic at the chronic phase (< 6 months) Written informed consent subject having a social insurance Subject who consent to complete all the study's experiments Healthy controls group: Man or Woman Age 18-80y No history of neurological or psychiatric disease. Exclusion Criteria: Stroke group Subject who is unable to consent (due to dementia, severe aphasia, psychiatric disorder...) History of other neurologic disorders Significant le vel of depression or anxiety, assessed by the STAI and the BDI questionnaires Non corrected visual loss Subjects suffering from visual neglect (assessed by the Bells Test and a bisection test (20mm) contra-indications to MRI pregnant or breastfeeding woman Women of childbearing age without effective contraception Healthy controls group Subject who is unable to consent (due to dementia, severe aphasia, psychiatric disorder...) History of neurologic disorders Significant level of depression or anxiety, assessed by the STAI and the BDI questionnaires Non-corrected visual loss contra-indications to MRI pregnant or breastfeeding woman Women of childbearing age without effective contraception

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Stroke<br>Stroke patients (ischemic or hemorrhagic) in the chronic phase (> 6 months) | |
| Healthy controls<br>Healthy adult controls | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| BOLD signal when fear visual recognition | Compare correlations of cerebral functional activations (BOLD) by fMRI between groups when stimulus = fear | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| BOLD signal when happiness visual recognition | Compare correlations of cerebral functional activations (BOLD) by fMRI between groups when stimulus = happiness | 1 day | 
| Electrical connectivity (EEG) when fear visual recognition | Compare cerebral networks activated by a fear visual task recognition in both groups | 1 day | 
| Electrical connectivity (EEG) when fear happiness visual recognition | Compare cerebral networks activated by a happiness visual task recognition in both groups | 1 day | 
| Electrical connectivity (EEG) when emotions auditory recognition | Compare cerebral networks activated by an auditory task recognition in both groups | 1 day | 
| Relationship between behavioral performance and cerebral networks | Correlations between fMRI and EEG networks vs. behavioral performance (emotion recognition) | 1 day | 
| Structural connectivity | Disconnectome maps in the stroke patients group | 1 day | 
| Relationship between emotional self-assessment and cerebral networks | Correlation between the ESQ (emotional state questionnaire) and cerebral connectivity (EEG) and fMRI networks | 1 day | 
| Relationship between the behavioural performance in emotion recognition and executive functions | Correlation between behavioral performance in emotion recognition (Eckman Test) and executive functions (Stroop Test) in the stroke group | 1 day | 
| Relationship between lesion characteristics and the behavioral performance in emotion recognition | Correlation between lesion volume and the behavioural performance in emotion recognition (Eckman Test) | 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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stroke, emotions, neural bases