Premedication With Atenolol Versus Metoprolol for Controlled Hypotensive Anesthesia During Nasal Surgeries

Study Overview
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Brief Summary
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Objectives: To compare the safety and efficacy of oral atenolol versus oral metoprolol as a premedication for controlled hypotensive anesthesia during nasal surgeries. Background: Mucosal bleeding is the most frequent complication with nasal surgeries, as it interferes with the optimal visualization of the intranasal anatomy, increases operation time, and consequently increases blood loss. There are several pharmacological and non-pharmacological techniques for the appropriate control of intraoperative bleeding. Patients and Methods: This was a prospective, randomized, double-blind, phase four, comparative clinical trial; carried out on 60 patients, who were candidates for nasal surgeries under general anesthesia at our hospital. Patients were randomly allocated into two equal groups; group A, received oral atenolol, and group M, received oral metoprolol.

Official Title
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Premedication With Atenolol Versus Metoprolol for Controlled Hypotensive Anesthesia During Nasal Surgeries. A Randomized Clinical Trial

Conditions
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Hypotension Drug-Induced

Intervention / Treatment
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* Drug: Atenolol Succinate Oral Tablet
* Drug: Metoprolol Succinate Oral Tablet


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: American Society of Anesthesiologists (ASA) physical status ≤ II Age from 21 to 50 years Exclusion Criteria: ASA physical status > II Age < 21 years or > 50 years Pregnant women Breastfeeding Bronchial asthma Chronic obstructive pulmonary disease Diabetes Mellitus Hypertension Ischemic heart disease Rheumatic heart disease Heart failure Heart block Sick sinus syndrome Sinus bradycardia Chronic hypotension Anemia (Hb < 10 g/dl) Renal or hepatic dysfunction Central nervous system disease Allergic fungal sinusitis Patients on beta-blockers Alcohol or drug abuse Anticoagulation therapy, Bleeding diathesis Agents influencing autonomic nervous system Allergy to the study drugs Any contraindication of oral intake

Ages Eligible for Study
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Minimum Age: 21 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Group A (n=30)<br>Atenolol group | Drug: Atenolol Succinate Oral Tablet<br>* Atenolol 50 mg<br>* Other names: Tenormin tablets;|
| Active Comparator: Group M (n=30)<br>Metoprolol group | Drug: Metoprolol Succinate Oral Tablet<br>* Metoprolol 100 mg<br>* Other names: Seloken ZOC tablets;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mean and Standard deviation of Blood loss (ml)(mean±SD) | Amount of blood loss at the end of surgery | 5 minutes after the end of surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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atenolol, controlled hypotension, metoprolol, nasal surgery