Prostate Cancer Screening and Dietary Heterocyclic Amines in African American Men

Study Overview
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Brief Summary
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RATIONALE: Screening may help doctors find prostate cancer sooner, when it may be easier to treat. The amount of heterocyclic amines in the diet may affect prostate cancer screening results and the risk of prostate cancer. PURPOSE: This phase II trial is studying prostate cancer screening and dietary heterocyclic amines in African American men.

Detailed Description
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OBJECTIVES: Estimate dietary heterocyclic amine (HA) exposure in African American men who use HA-forming meats and cooking methods. Correlate dietary HA exposure with prostate-specific antigen and digital rectal exam screening results (i.e., higher HA exposure with increased abnormality in prostate cancer screening results) in these participants. OUTLINE: This is a prospective study. Participants complete a routine medical questionnaire and undergo a detailed dietary interview that focuses on meat consumption, cooking preferences, and other factors that may be associated with prostate cancer risk. Participants then undergo a digital rectal exam (DRE) and blood collection for prostate-specific antigen (PSA) testing (total PSA and % free PSA). Results of PSA testing and DRE, including follow-up instructions (if needed), are sent to the participant 3-4 weeks later. Blood samples are also examined by phenotypic assays for UV-damage induced nucleotide excision-repair capacity. PROJECTED ACCRUAL: A total of 800 participants will be accrued for this study.

Official Title
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Prostate Cancer Screening and Dietary HA Exposure in African-Americans: Phase II

Conditions
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Prostate Cancer

Intervention / Treatment
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* Other: physiologic testing
* Other: study of socioeconomic and demographic variables
* Procedure: evaluation of cancer risk factors
* Procedure: mutation carrier screening
* Procedure: study of high risk factors


Participation Criteria
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Eligibility Criteria
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DISEASE CHARACTERISTICS: African American male No previous diagnosis of prostate cancer Desires prostate cancer screening as a routine preventative medical service PATIENT CHARACTERISTICS: Lives in or near Oakland, California Speaks English No medical or other disability (e.g., blindness, psychological dysfunction, or amputation) that would preclude study participation PRIOR CONCURRENT THERAPY: Not specified

Ages Eligible for Study
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Minimum Age: 50 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Screening


Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: physiologic testing|nan|
|Other: study of socioeconomic and demographic variables|nan|
|Procedure: evaluation of cancer risk factors|nan|
|Procedure: mutation carrier screening|nan|
|Procedure: study of high risk factors|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Dietary heterocyclic amine (HA) exposure in African American men |  |  | 
| Correlation of HA exposure with prostate cancer screening results |  |  | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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prostate cancer