Human Papillomatosis Genotyping of Children in Thailand

Study Overview
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Brief Summary
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The purpose of the present study was to identify risk factors for more severe juvenile Recurrent Respiratory Papillomatosis (RRP) through prospective evaluation of a pediatric population in Thailand by the employing a protocol that includes staging of disease severity using above mentioned staging system at the time of each endoscopic debridement, as well as human papilloma virus (HPV) genotyping.

Detailed Description
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Recurrent respiratory papillomatosis is caused by human papilloma virus and is the most common benign laryngeal neoplasm in children. Although RRP is rarely fatal, the disease requires prolonged, extensive medical and surgical treatment, and causes physical and emotional suffering in affected children and their families. Although recurrent respiratory papillomatosis is a relatively unusual problem, it accounts for significant health are expenditures.The goal of management of RRP is control of the disease, preservation of the voice and prevention of major complication .The purpose of study will identify risk factors for more severe juvenile RRP through prospective evaluation of a pediatric population in Thailand by the employing a protocol that includes staging of disease severity , as well as HPV genotyping. Objective: To identify the genotypes of HPV isolated from Thai RRP patients To compare staging and severity with HPV genotypes To correlate the following characteristics of the Thai RRP patients with the HPV genotypes

Official Title
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Human Papillomatosis Genotyping and Severity in Patients With Recurrent Respiratory Papillomatosis of Children in Thailand

Conditions
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Recurrent Laryngeal Papillomatosis, Human Papilloma Virus

Intervention / Treatment
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* Procedure: biopsy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients have active laryngeal papillomatosis . Patients have developed this infection before the age of 18 years old. Exclusion Criteria: Children whose families do not sign an informed consent to enter into study. Children whose families anticipate discontinuing care at a participating institution during the study period.

Ages Eligible for Study
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Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: biopsy|excisional biopsy|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Human Papillomavirus Genotypes | Distribution of Human papillomavirus(HPV) genotypes identified in the biopsy | 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cotreta-Derkay Score | We compared disease severity(Cotreta-Derkay score) between groups of children with two different HPV genotypes Coltera and Derkay have evolved a staging system to stage recurrent papillomatous lesions involving the respiratory tract. Coltera-Derkay method of staging : Clinical score: Voice: Normal - 0, Abnormal - 1, Aphonia - 2 Stridor: Absent - 0, Present on activity - 1, Present at rest - 2 Respiratory distress - None - 0, Mild - 1, Moderate - 2, Severe - 3, Extreme - 4. Anatomical score: For each site - 0 = none, 1=surface lesion, 2= raised lesion, 3=bulky lesion. Total score = Anatomical score + Total clinical score | 12 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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RRP, HPV