Allergen Provocations- HCA Children's Hospital

Study Overview
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Brief Summary
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A prospective study of all allergen provocations performed in children at the Hans Christian Andersen Children's Hospital.

Detailed Description
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The purpose of the study is to investigate the impact of co-morbidities, history, and allergen tests on the outcome of allergen provocation tests. Subjects are children aged 0-18 years old investigated for allergy to foods or antibiotics. Data entered in the database are demographics, co-morbidities, symptoms, SPT, specific IgE and details of the allergen provocations.

Official Title
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Allergen Provocations at Hans Christian Andersen Children's Hospital

Conditions
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Allergy in Children

Intervention / Treatment
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* Diagnostic Test: Oral provocation test


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: clinical suspicion of allergy to foods or antibiotics informed concent - Exclusion Criteria: -

Ages Eligible for Study
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Minimum Age: 0 Years
Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Antibiotics<br>Children aged 0-18 years investigated for allergy to antibiotics | Diagnostic Test: Oral provocation test<br>* Titrated provocation with allergen<br>|
| Milk<br>Children aged 0-18 years investigated for allergy to milk | Diagnostic Test: Oral provocation test<br>* Titrated provocation with allergen<br>|
| Egg<br>Children aged 0-18 years investigated for allergy to egg | Diagnostic Test: Oral provocation test<br>* Titrated provocation with allergen<br>|
| Peanut<br>Children aged 0-18 years investigated for allergy to peanut | Diagnostic Test: Oral provocation test<br>* Titrated provocation with allergen<br>|
| Hazelnut<br>Children aged 0-18 years investigated for allergy to hazelnut | Diagnostic Test: Oral provocation test<br>* Titrated provocation with allergen<br>|
| Sesame<br>Children aged 0-18 years investigated for allergy to sesame | Diagnostic Test: Oral provocation test<br>* Titrated provocation with allergen<br>|
| Wheat<br>Children aged 0-18 years investigated for allergy to wheat | Diagnostic Test: Oral provocation test<br>* Titrated provocation with allergen<br>|
| walnut<br>Children aged 0-18 years investigated for allergy to walnut | Diagnostic Test: Oral provocation test<br>* Titrated provocation with allergen<br>|
| cashew<br>Children aged 0-18 years investigated for allergy to cashew | Diagnostic Test: Oral provocation test<br>* Titrated provocation with allergen<br>|
| Pistachio<br>Children aged 0-18 years investigated for allergy to pistachio | Diagnostic Test: Oral provocation test<br>* Titrated provocation with allergen<br>|
| Almond<br>Children aged 0-18 years investigated for allergy to almond | Diagnostic Test: Oral provocation test<br>* Titrated provocation with allergen<br>|
| Soy<br>Children aged 0-18 years investigated for allergy to soy | Diagnostic Test: Oral provocation test<br>* Titrated provocation with allergen<br>|
| Fish<br>Children aged 0-18 years investigated for allergy to fish | Diagnostic Test: Oral provocation test<br>* Titrated provocation with allergen<br>|
| Shellfish<br>Children aged 0-18 years investigated for allergy to shellfish | Diagnostic Test: Oral provocation test<br>* Titrated provocation with allergen<br>|
| Poppy seed<br>Children aged 0-18 years investigated for allergy to poppy seed | Diagnostic Test: Oral provocation test<br>* Titrated provocation with allergen<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The association of allergy tests with the result of allergen provocation | The value of specific IgE and SPT to predict the outcome of a allergen provocation | 5 years |