Endometrioma Related Reduced Ovarian Reserve

Study Overview
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Brief Summary
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Prior studies have shown surgical excision of endometriomas are associated with a decline in ovarian reserve as assessed by serum anti-Mullerian Hormone (AMH) levels. However, the natural history of serum AMH levels in the presence of untreated endometriomas are unknown. Purpose of this study is to determine whether the presence of endometriomas cause a faster decline in serum AMH levels than in healthy women over a six months period.

Detailed Description
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The study is a prospective cohort study. Women diagnosed with endometriomas by transvaginal or transabdominal ultrasound or MRI will be recruited from a tertiary care endometriosis clinic. Age matched healthy controls will be recruited from the staff of the same hospital. A priorly published historical group of women who underwent endometrioma excision will be a second comparator.

Official Title
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The Effect Of The Presence Of Endometriomas On Ovarian Reserve

Conditions
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Endometriosis

Intervention / Treatment
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* Procedure: laparoscopic endometrioma excision
* Other: Conservative follow up


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Reproductive age Endometrioma without indication for surgery or treatment with combined contraceptive, progestin or other hormonal intervention. Exclusion Criteria: Menstrual cycle irregularity Polycystic ovarian syndrome Women who were pregnant or contemplating pregnancy in the next six months History of ovarian surgery Using medication which could affect ovarian function during six months before recruitment Indication for surgical excision

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Endometrioma<br>Reproductive aged women diagnosed with endometrioma. Conservative follow up for six months. | Other: Conservative follow up<br> <br> |
| Healthy Controls<br>Women with regular menstrual cycles and without ovarian pathology will be recruited from physicians, nurses and other staff of the same hospital. Controls will be matched for age with the women in the endometrioma group. They will be conservatively followed up for six months. | Other: Conservative follow up<br> <br> |
| Historical controls who underwent surgical excision<br>20 women who underwent surgical excision of endometrioma in the same clinic had serum AMH levels measured preoperatively and on post operative sixth month. Their values will be compared with that of endometrioma group. These data were priorly published in detail (Uncu et al. 2013). | Procedure: laparoscopic endometrioma excision<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Serum Anti- mullerian hormone (AMH) level |  | at recruitment and six months later | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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AMH, ovarian endometriomas, ovarian reserve