Exercise Training in Asthma

Study Overview
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Brief Summary
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The aim of the study is to compare two methods of exercise training: alternate load versus constant load realized at moderate or high intensities, in order to define the interests and the limits of each one of these two methods. The finality is to make possible to the expert to choose what exercise training induces the best results quickly and to make its choice according to the therapeutic objectives which it lays down.We also evaluate the effects of these exercises training on the vagal response and the bronchial tone of the asthmatics. From a clinical point of view, a close attention will be paid to the effects of these exercises training on the control of asthma and the quality of life of the subjects

Official Title
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Comparison of Two Types of Exercise Training for Asthmatic Subjects : Interests and Limits

Conditions
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Asthma

Intervention / Treatment
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* Other: Exercise training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 18 to 45 years old mild to moderate persistent asthma (GINA classification) stabilized asthma physical activity level between 5 and 11 (Baecke and coll, 1982) no contra-indication for physical training Exclusion Criteria: cardiovascular pathology metabolic pathology traumatic pathology BMI≥30 tobacco diabetes

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: CA<br>Exercise training with alternate load | Other: Exercise training<br>* Comparison of two methods of exercise training: alternate load versus constant load realized at moderate or high intensities<br>|
| Active Comparator: CC<br>Exercise training with constant load | Other: Exercise training<br>* Comparison of two methods of exercise training: alternate load versus constant load realized at moderate or high intensities<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Maximal oxygen consumption (VO2max) |  | At T-1 = eight weeks before training - At T0 = beginning of training - At T1 = eight weeks after training | 
| Maximal power output (Pmax) |  | At T-1 = eight weeks before training - At T0 = beginning of training - At T1 = eight weeks after training | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Exhaled NO (eNO) |  | At T-1 = eight weeks before training - At T0 = beginning of training - At T1 = eight weeks after training | 
| Heart rate variability |  | At T-1 = eight weeks before training - At T0 = beginning of training - At T1 = eight weeks after training | 
| Force Expiratory Volume in one second (FEV1) |  | At T-1 = eight weeks before training - At T0 = beginning of training - At T1 = eight weeks after training | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Asthma, Asthmatic subjects, Exercise training, Constant load, Alternate load