Angiography Derived Index of Microcirculatory Resistance in Patients With Acute Myocardial Infarction

Study Overview
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Brief Summary
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Coronary microcirculatory dysfunction has been known to be prevalent even after successful revascularization of acute myocardial infarction (AMI) patients, and has been shown to be associated with poor prognosis. Angiography derived index of micro-circulatory resistance (Angio-IMR) is a novel pressure-wire free approach to assess coronary microvascular disease with great diagnostic performance. The current study will further investigate the prognostic value of Angio-IMR in patients with AMI in multicenter retrospective cohort.

Official Title
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Angiography Derived Index of Microcirculatory Resistance in Patients With Acute Myocardial Infarction

Conditions
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Acute Myocardial Infarction (AMI)

Intervention / Treatment
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* Other: Angiography derived index of micro-circulatory resistance (Angio-IMR)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Acute myocardial infarction patients who underwent successful percutaneous coronary intervention Exclusion Criteria: No appropriate coronary angiography images (inferior image quality, image loss, severe arteries overlap, or significant artifact) Previous coronary artery bypass graft

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| STEMI with high Angio-IMR<br>Patients with ST segment elevation myocardial infarction and high Angio-IMR | Other: Angiography derived index of micro-circulatory resistance (Angio-IMR)<br>* Angiography derived index of micro-circulatory resistance (Angio-IMR) post percutaneous coronary intervention.<br>|
| STEMI with low Angio-IMR<br>Patients with ST segment elevation myocardial infarction and low Angio-IMR | Other: Angiography derived index of micro-circulatory resistance (Angio-IMR)<br>* Angiography derived index of micro-circulatory resistance (Angio-IMR) post percutaneous coronary intervention.<br>|
| NSTEMI with high Angio-IMR<br>Patients with non-ST segment elevation myocardial infarction and high Angio-IMR | Other: Angiography derived index of micro-circulatory resistance (Angio-IMR)<br>* Angiography derived index of micro-circulatory resistance (Angio-IMR) post percutaneous coronary intervention.<br>|
| NSTEMI with low Angio-IMR<br>Patients with non-ST segment elevation myocardial infarction and low Angio-IMR | Other: Angiography derived index of micro-circulatory resistance (Angio-IMR)<br>* Angiography derived index of micro-circulatory resistance (Angio-IMR) post percutaneous coronary intervention.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cardiac death or readmission for heart failure in 1 month | Incidence of cardiac death or readmission for heart failure during first 1 month follow-up. | 1 month | 
| Cardiac death or readmission for heart failure in 6 months | Incidence of cardiac death or readmission for heart failure during first 6 months follow-up. | 6 month | 
| Cardiac death or readmission for heart failure in 1 year | Incidence of cardiac death or readmission for heart failure during first 1 year follow-up. | 1 year | 
| Cardiac death or readmission for heart failure in 2 years | Incidence of cardiac death or readmission for heart failure during first 2 years follow-up. | 2 year |