Effects of Abdominal Nerve Block on Postoperative Recovery in Patients Undergoing Gastrointestinal Surgery

Study Overview
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Brief Summary
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To explore the effect of general anesthesia combined with transversus abdominis plane block (TAPB) and/or rectus sheath block (RSB) on the recovery of patients with gastrointestinal tumor after surgical treatment.

Official Title
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Effects of Abdominal Nerve Block on Postoperative Recovery in Patients Undergoing Gastrointestinal Surgery

Conditions
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Colon Cancer, Rectal Cancer, Gastric Cancer

Intervention / Treatment
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* Other: Group Abdominal Nerve Block with local anesthetics
* Other: Group Abdominal Nerve Block with saline


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Aged 18 to 80 years. ASA 1-3. Clinical diagnosis of gastric carcinoma and colorectal cancer without metastasis. Surgery for gastrointestinal surgery. Exclusion Criteria: Patients and their family members refuse to accept the clinical trial; Complicated with acute cholangitis, gastrointestinal bleeding or ascites, etc.; Hepatic encephalopathy, psychosis or neuropathy; Body weight for acid-base and electrolyte imbalances, endotoxemia, and cachexia decreased by more than 2% or 5% in the past 2 months or 6 months. Uncontrolled hypertentsion, coronary heart disease, diabetes.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Group Abdominal Nerve Block<br>surgical under general anesthesia combined with transversus abdominis plane block (TAPB) and/or rectus sheath block (RSB) with 0.2% ropivacaine | Other: Group Abdominal Nerve Block with local anesthetics<br>* surgical under general anesthesia combined with transversus abdominis plane block (TAPB) and/or rectus sheath block (RSB) with 0.2% ropivacaine<br>|
| Placebo Comparator: Group control<br>surgical under general anesthesia combined with transversus abdominis plane block (TAPB) and/or rectus sheath block (RSB) with 0.9% saline. | Other: Group Abdominal Nerve Block with saline<br>* surgical under general anesthesia combined with transversus abdominis plane block (TAPB) and/or rectus sheath block (RSB) with not 0.2% ropivacaine but 0.9% saline.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of postoperative chronic pain | The incidence of chronic pain 6 month after operation | 6 month after operation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Bedridden time | Postoperative bedridden time | The postoperative duration up to 15 days | 
| Fasting time | Postoperative fasting time | The postoperative duration up to 15 days | 
| Gastrointestinal decompression | Time of gastrointestinal decompression | The postoperative duration up to 15 days |