Nivolumab With Ipilimumab in Subjects With Neuroendocrine Tumors

Study Overview
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Brief Summary
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This is a single arm open-label design study looking at Nivolumab plus Ipilimumab in patients with Advanced Neuroendocrine Tumors. Patients will be dosed Nivolumab 240mg IV over 60 minutes every 2 weeks and Ipilimumab 1mg/kg IV over 30 minutes every 6 weeks. One cycle will include 3 doses of Nivolumab and 1 dose of Ipilimumab. The objective of this study is to evaluate the objective response rate of combination Nivolumab and Ipilimumab in advanced, well-differentiated neuroendocrine tumors. Durability of response, and PFS will also be described.

Detailed Description
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Subjects with progressive, non-functional advanced or metastatic thoracic, GI or pancreatic well-differentiated NETs have few treatment options. The only FDA approved treatment regimen offers little response potential. In currently unpublished data with inhibitory immune checkpoint agents, patients with NET have shown promising clinical benefit. This therapy offers a novel approach to potentially provide long term benefit, but must be further explored. The safety profile of nivolumab plus ipilimumab is characterized by immune-related toxicities, such as diarrhea, rash, pneumonitis, liver toxicity, and endocrinopathies (Nivolumab, Ipilimumab Investigator's Brochures). The frequencies and intensities of these events in the combination are variable and depend on the specific doses and schedule used. In the dosing schedules selected, these events were mostly low grade and manageable with the use of corticosteroids. Nivolumab and ipilimumab combination therapy has shown improved efficacy over either agent alone in melanoma. Rationale for Single Arm Design This study will use a single arm open-label design. The objective of this study is to evaluate the objective response rate of combination nivolumab and ipilimumab in advanced, well-differentiated neuroendocrine tumors. Durability of response, and PFS will also be described.

Official Title
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An Open-Label, Single Arm Phase II Study of Nivolumab in Combination With Ipilimumab in Subjects With Advanced Neuroendocrine Tumors

Conditions
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Neuroendocrine Tumors, Carcinoid Tumor

Intervention / Treatment
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* Drug: Nivolumab
* Drug: Ipilimumab


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Subjects with histologically confirmed advanced, progressive, well-differentiated nonfunctional NET of the pancreas, lung or gastrointestinal (GI) tract per the 8th International Association for the Study of Lung Cancer classification (IASLC) or the American Joint Committee on Cancer (AJCC) Staging Handbook, 7th edition. Progression must be documented over the prior 12 months. Measurable disease by CT or MRI per RECIST 1.1 criteria (Appendix 3); radiographic tumor assessment performed within 28 days before treatment. Target lesions may be located in a previously irradiated field if there is documented (radiographic) disease progression in that site after the completion of radiation therapy. Prior therapy, including everolimus, octreotide, surgery, chemoradiation, is all permitted after being properly noted. This prior therapy must have been completed at least 28 days prior to study enrollment. Patients with lung NETs must have progressed after at least 1 line of therapy. Patients with GI NETs must have had at least 2 lines of prior therapy. Subjects are to have tumor tissue sample available at central lab for PD -L1 IHC testing during the screening period. Subjects can initiate therapy before the result of IHC testing. (Stage 2 only) Subjects must be willing to undergo 2 sets of core needle biopsies (pre-treatment and at 6-8 weeks on therapy) if there are lesions amenable to biopsy. Subjects without a lesion amendable to biopsy will still be permitted to enroll provided they have an archival tumor sample for PD-L1 IHC testing. An optional core biopsy will be requested at progression. ECOG performance status ≤ 1 (see Appendix 1) Prior palliative radiotherapy to non-CNS lesions must have been completed at least 2 weeks prior to treatment. Subjects with symptomatic tumor lesions at baseline that may require palliative radiotherapy within 4 weeks of first treatment are strongly encouraged to receive palliative radiotherapy prior to treatment. Patients must have normal organ and marrow function as defined below: - WBC ≥1,500/mcL - absolute neutrophil count ≥1,000/mcL - hemoglobin ≥ 8.0 g/dL - platelets ≥75,000/mcL - total bilirubin ≤ 1.5 x institutional ULN (patients with Gilbert's syndrome may have serum bilirubin ≤ 3 x ULN) - AST/ALT ≤ 3 × institutional ULN (≤ 5 x ULN in the presence of liver metastases) - creatinine ≤ 1.5 × institutional ULN or creatinine clearance (CrCl) ≥ 40 mL/min (if using the Cockcroft-Gault formula below): Female: CrCl = (140 - age in years) x weight in kg x 0.85 o 72 x serum creatinine in mg/dL Male: CrCl = (140 - age in years) x weight in kg x 1.00 - 72 x serum creatinine in mg/dL Age ≥18 years of age Patients must have recovered from adverse events due to prior treatment to ≤ grade 1, except for alopecia and sensory neuropathy ≤ grade 2. Patients must be able to understand and the willingness to sign a written informed consent document. Exclusion Criteria: Subjects with poorly differentiated or small cell carcinoma histology Subjects with disease that is amenable to surgical resection. Subjects with history of or active symptoms of carcinoid or hormonal syndromes are permitted if symptoms are controlled with a somatostatin analog. Hepatic intra-arterial embolization or peptide receptor radionuclide therapy (PRRT) within 4-8 weeks; cryoablation, radiofrequency ablation or trans-arterial chemoembolization of hepatic metastases within ≤ 4 weeks of study enrollment Subjects with symptomatic untreated CNS metastases are excluded. Subjects are eligible if CNS metastases are asymptomatic or adequately treated and subjects are neurologically returned to baseline (except for residual signs or symptoms related to the CNS treatment) for at least 2 weeks prior to first treatment. In addition, subjects must be either off corticosteroids, or on a stable or decreasing dose of <10 mg daily prednisone (or equivalent) for at least 2 weeks prior to first treatment. Subjects with carcinomatous meningitis Subjects must have recovered from the effects of major surgery or significant traumatic injury at least 14 days before first treatment. Pregnant or breast-feeding women Women of child-bearing potential, who are biologically able to conceive, and not employing two forms of highly effective contraception. Highly effective contraception must be used throughout the trial and up to 8 weeks after the last dose of study drug (e.g. male condom with spermicidal; diaphragm with spermicide; intra-uterine device). Women of child-bearing potential, defined as sexually mature women who have not undergone a hysterectomy or who have not been naturally postmenopausal for at least 12 consecutive months (i.e., who has had menses any time in the preceding 12 consecutive months), must have a negative serum pregnancy test ≤ 14 days prior to starting study drug. Subjects with an active, known or suspected autoimmune disease. Subjects with type I diabetes mellitus, hypothyroidism only requiring hormone replacement, skin disorders (such as vitiligo, psoriasis, or alopecia) not requiring systemic treatment, or conditions not expected to recur in the absence of an external trigger are permitted to enroll. Other active malignancy requiring concurrent intervention. Subjects with a condition requiring systemic treatment with either corticosteroids (> 10 mg daily prednisone equivalent) or other immunosuppressive medications within 14 days of first treatment. Inhaled or topical steroids, and adrenal replacement steroid 10 mg daily prednisone equivalent, are permitted in the absence of active autoimmune disease. Subjects with interstitial lung disease that is symptomatic or may interfere with the detection or management of suspected drug-related pulmonary toxicity. Known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS). Known medical condition that, in the investigator's opinion, would increase the risk associated with study participation or study drug administration or interferes with the interpretation of safety results. Prior treatment with an anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CTLA-4 antibody, or any other antibody or drug specifically targeting T-cell co-stimulation or checkpoint pathways Any positive test for hepatitis B virus or hepatitis C virus indicating acute or chronic infection History of allergy or hypersensitivity to study drug components

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 100 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Nivolumab plus Ipilimumab<br>Nivolumab-240 mg IV over 60 minutes Q2W Ipilimumab 1mg/kg IV over 30 minutes Q6W | Drug: Nivolumab<br>* 240mg IV over 60 minutes Q2W<br>Drug: Ipilimumab<br>* 1mg/kg IV over 30 minutes Q6W<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Objective Response Rate of neuroendocrine tumor (NET) of the lung | Proportion of participants with reduction in size of advanced, progressive, well-differentiated nonfunctional neuroendocrine tumor (NET) of the lung treated with nivolumab plus ipilimumab. | 6 weeks post-intervention | 
| Objective Response Rate of neuroendocrine tumor (NET) of the pancreas | Proportion of participants with reduction in size of advanced, progressive, well-differentiated nonfunctional neuroendocrine tumor (NET) of the pancreas treated with nivolumab plus ipilimumab. | 6 weeks post-intervention | 
| Objective Response Rate of neuroendocrine tumor (NET) of the gastrointestinal (GI) tract | Proportion of participants with reduction in size of advanced, progressive, well-differentiated nonfunctional neuroendocrine tumor (NET) of the gastrointestinal (GI) tract treated with nivolumab plus ipilimumab. | 6 weeks post-intervention | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Safety as assessed by number of treatment-emergent adverse events | Number of treatment-emergent adverse events (safety and tolerability) of nivolumab plus ipilimumab by characterization of toxicities in subjects with advanced well-differentiated nonfunctional NET of the lung, pancreas or GI tract. | 2 weeks post-intervention | 
| Safety as assessed by number of treatment dose interruptions | Quantification of treatment dose interruptions in subjects with advanced well-differentiated nonfunctional NET of the lung, pancreas or GI tract. | 2 weeks post-intervention | 
| Efficacy as assessed by Progression Free Survival (PFS) at 6 months | Efficacy via progression free survival (PFS) at 6 months of the combination of nivolumab and ipilimumab in subjects with advanced well-differentiated nonfunctional NET of the lung, pancreas or GI tract | 6 months post-intervention | 
| Efficacy as assessed by Progression Free Survival (PFS) at 12 months | Efficacy via progression free survival (PFS) at 12 months of the combination of nivolumab and ipilimumab in subjects with advanced well-differentiated nonfunctional NET of the lung, pancreas or GI tract | 12 months post-intervention | 
| Efficacy as assessed by Progression Free Survival (PFS) at 24 months | Efficacy via progression free survival (PFS) at 24 months of the combination of nivolumab and ipilimumab in subjects with advanced well-differentiated nonfunctional NET of the lung, pancreas or GI tract | 24 months post-intervention | 
| Median progression free survival | Median number months without disease progression | up to 2 years post-intervention | 
| Efficacy as assessed by disease control rate (DCR) | Percentage of participants who achieve partial or complete response to combination of nivolumab and ipilimumab. | 2 years post-intervention | 
| Efficacy as assessed by Duration of Response (DOR) | Number of months from documentation of tumor response to disease progression | Up to 2 years post-intervention | 
| Efficacy as assessed by Overall Survival (OS) | Number of months participants stay alive after treatment with the combination of nivolumab and ipilimumab in subjects with advanced well-differentiated nonfunctional NET of the lung, pancreas or GI tract | Up to 2 years post-intervention |