Cognitive Remote Assessment Using FLAME (CRA-FLAME)

Study Overview
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Brief Summary
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We aim to use a multimodal approach comprising conventional neuropsychological cognitive tests, fluid and imaging biomarker data, to explore their association with the FLAME unsupervised cognitive computerized assessment. We believe that this would provide critical information to move forward the current research framework in the field. Participants will be selected from BBRC-sponsored studies, such as the ALFA project (STUDY 45-65 FPM/2012), the ALFA+ cohort study (ALFA - FPM - 0311), the Beta-AARC study (β-AARC_BBRC2020) or the BarcelonaBeta Dementia Prevention Research Clinic study (BBRC-DemPrev-2018)

Detailed Description
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We aim to use a multimodal approach comprising conventional neuropsychological cognitive tests, fluid and imaging biomarker data, to explore their association with the FLAME unsupervised cognitive computerized assessment. We believe that this would provide critical information to move forward the current research framework in the field. Participants will be selected from BBRC-sponsored studies, such as the ALFA project (STUDY 45-65 FPM/2012), the ALFA+ cohort study (ALFA - FPM - 0311), the Beta-AARC study (β-AARC_BBRC2020) or the BarcelonaBeta Dementia Prevention Research Clinic study (BBRC-DemPrev-2018)

Official Title
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Cognitive Remote Assessment Using FLAME (CRA-FLAME)

Conditions
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Cognitive Impairment

Intervention / Treatment
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* Other: Remote cognitive testing


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Participants must meet ALL the following criteria: To sign the study informed consent form approved by the corresponding authorities. Men and women that have participated/are participating in a BBRC-sponsored study. To accept that: The results obtained in this study may be published in scientific journals and at BBRC's communication channels (e.g. web page) The data gathered may be used in combination with those gathered in other BBRC-sponsored studies in which they may (have) participate(d) Exclusion Criteria: 1. Not having an ICT literacy enough to access and complete the online tests.

Ages Eligible for Study
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Minimum Age: 45 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cognitively unimpaired<br>Cognitively unimpaired participants from BBRC-sponsored studies | Other: Remote cognitive testing<br>* Remote cognitive testing<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| FLAME global composite score | calculated by combining information from two web-based online neuropsychological test batteries that are already integrated in a unique platform: the PROTECT Cognitive Tests System (PCTS) (Corbett et al., 2015) and the CogTrackTM (Wesnes et al., 2017) | through study completion, an average of 3 years |