Facial Expression Recognition of Emotion and Categorization of Emotional Words in Gilles de la Tourette's Syndrome

Study Overview
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Brief Summary
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Gilles de la Tourette's syndrome is a childhood onset inherited neuropsychiatric disorder characterised by the presence of both multiple motor tics and one or more vocal tics (noises), with psychiatric and/or behaviour disorders (such as obsessive compulsive behaviour…). This disease is associated with an dopamine system imbalance which could be responsible of a specific trouble in the recognition in some facial expression. This has been already shown in Gilles de la Tourette patients with obsessive compulsive behaviour. We hypothesise that patients with Gilles de la Tourette's syndrome present a dysfunction of voluntary and automatic treatment of emotional information. The main purpose of this study is to show if patients with Gilles de la Tourette's syndrome present a lack of specific facial expression recognition of emotion and determinate more precisely if this alteration involves the cortical way (high frequency way) or the under cortical way (low frequency way).

Detailed Description
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20 patients with Gilles de la Tourette's syndrome compared to 20 healthy paired volunteers. Study progress (patients): Inclusion visit : Psychiatric evaluation Psychological evaluation Ophthalmic visit Protocol : Facial expression recognition test Lexical decision test Study progress (healthy volunteers): Psychiatric evaluation Ophthalmic visit Facial expression recognition test Lexical decision test

Official Title
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Facial Expression Recognition of Emotion and Categorization of Emotional Words in Gilles de la Tourette's Syndrome

Conditions
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Gilles de la Tourette's Syndrome

Intervention / Treatment
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* Behavioral: Facial expression recognition of emotion


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age : >18 years Patient with a Gilles de la Tourette 's syndrome such as defined in the DSMIV Stability of treatment >1 month Mini Mental State > 26 Affiliation to social security Agreement of patients Exclusion Criteria: Patients with cognitive disorders, dementia, mental retardation… Patients with serious neurological pathologies Patients with a vision contrast altered. Patients who do not understand the words associated with an emotion Pregnant women Person who participate to an other study

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 2<br>One group with Gilles de la Tourette's Syndrome One group with healthy paired volunteers | Behavioral: Facial expression recognition of emotion<br>* Facial expression recognition test Lexical decision test<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Facial expression recognition test |  | % of exact responses | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Lexical decision test |  | The time to respond | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Gilles de la Tourette's syndrome, Facial expression recognition of emotion, Frequency levels, Automatic and voluntary information treatment, Patient with Gilles de la Tourette's syndrome