Interactive E-health Database for the Identification of Potential Interactions Among Drugs Prescribed to CKD Patient

Study Overview
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Brief Summary
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The aim of the current project is the development and implementation of an e-health database of drug interactions (drug-drug, drug-food, drug-alcohol and drug-herbal products interaction) to CKD patients in order to achieve a holistic approach to patient care and personalized medicine. The study will be conducted in the University of Ioannina (cooperation between the Department of Nephrology and the Laboratory of Physiology). Data will be collected form 150 CKD patients (Stages 1-5 pre-dialysis, undergoing dialysis, kidney transplantation). Sixty patients will be selected for the pilot study which will include blood and urine tests and specific polymorphism analysis (pharmacogenetic tests). Pilot implementation of the e-health database will be undertaken by health professionals of the Department of Nephrology (University Hospital of Ioannina) to test the system in realistic setting (usability, efficiency and efficacy) in order to make the necessary changes prior to full scale deployment.

Official Title
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Development of an Interactive E-health Database Aimed to Identify Potential Interactions Among Drugs Prescribed to Chronic Kidney Disease (CKD) Patient

Conditions
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Renal Insufficiency, Chronic

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age>18 years CKD diagnosis according to KDOQI Guidelines absence of active malignancy absence of decompensated heart failure New York Heart Association (NYHA) IV absence of liver cirrhosis patient's consent Exclusion Criteria: Age<18 years active malignancy decompensated heart failure NYHA IV liver cirrhosis patient's refusal to participate in the study

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| CKD Patients<br>Patients (n=150) with CKD (Stages 1-5 pre-dialysis, undergoing dialysis, kidney transplantation) who fulfil the inclusion criteria from the Nephrology Dept and Renal Transplant Unit of the University Hospital of Ioannina. Sixty patients will be selected for the pilot study which will include blood and urine tests and specific polymorphism analysis (pharmacogenetic tests) | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| E-health database | E-health database of drug interactions (drug-drug, drug-food, drug-alcohol and drug-herbal products interaction) to CKD patients in order to achieve a holistic approach to patient care and personalized medicine. | 1-12 months until completion of patients recruitment | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Drug Interactions, Polymorphism, Genetic, Pharmacogenetics, Databases, Pharmaceutical