The Effects of Physical Exercise Training in Patients With Chronic Obstructive Pulmonary Disease

Study Overview
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Brief Summary
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The purpose of the present project is to investigate the physiological effects of two different types of exercise training in COPD patients. The patients will be examined before, during and after 8 weeks of training to evaluate the effect of different types of skeletal muscle stimulation on health related quality of life, 6 min walking distance, flow mediated dilation, and histological properties of skeletal muscle cells, regarding oxidative capacity, fiber type, purinergic receptor amounts and measures of systemic inflammation. The study will test the hypothesis that: Resistance training is superior to endurance training in patients with COPD

Official Title
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The Effects of Physical Exercise Training in Patients With Chronic Obstructive Pulmonary Disease

Conditions
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COPD, Exercise, Resistance Training

Intervention / Treatment
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* Behavioral: Resistance training
* Behavioral: Endurance training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: FEV1/FVC fixed ratio <0.70, FEV1: <60% of predicted and MRC > or equal to 3 Arterial oxygen saturation at rest> 90%, BMI >18, LVEF> 45. Age: 40 - 80 years The medical treatment will be continued unchanged during the study and additional prednisolone and /or antibiotic treatment will be prescribed in case of acute exacerbation. Exclusion Criteria: Unstable ischemic heart disease, severe heart valve failure, pulmonary emboli, severe heart failure, severe infections, musculoskeletal disorders, malignant disease, contraindicated medicine as MAO inhibitors and anticoagulants.

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Patients with COPD<br>Patients with COPD are to be trained 3 times a week for 8 weeks | Behavioral: Resistance training<br> <br> * Other names: Strength training, skeletal muscle, exercise, muscle training;|
| Active Comparator: Control patients with COPD<br>Control patients with COPD are to be trained 3 times a week for 8 weeks | Behavioral: Endurance training<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Skeletal muscle function | Muscle biopsy | At baseline and after 8 weeks of traning | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Flow mediated dilation | Endothelium function | Change from baseline at 8 weeks | 
| Body composition | DEXA scan | Change from baseline at 8 weeks | 
| 6 min walking test |  | Change from baseline at 8 weeks | 
| Health Related Quality of Life - COPD assessment test (CAT) |  | Change from baseline at 8 weeks |