Multi-channel aEEG in Cardiac Arrest Patients With Targeted Temperature Management

Study Overview
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Brief Summary
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This study aims to examine the prognostic value of 18 channel amplitude-integrated EEG (aEEG) in comatose cardiac arrest patients The study design is a prospective observational study. Cardiac arrest patients undergoing targeted temperature management (TTM) will participate in the study. Relation of aEEG in each channel with the neurologic outcome at 6 month after return of spontaneous circulation (ROSC) will be evaluated.

Detailed Description
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Normal trace was defined as continuous cortical activity on the raw EEG scan; in addition, the upper margin of the aEEG scan, referred to as the aEEG maximum, was >10 μ V, and the lower margin of the aEEG scan, referred to as the aEEG minimum, was >5 μ V. The Time from ROSC to normal trace (TTNT, hours) is predictor of neurological outcome in these patients. We will evaluate the prognostic values of TTNTs in all aEEG channels.

Official Title
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Neurological Prognostication Using Multi-channel Amplitude-integrated Electroencephalographic Monitoring in Cardiac Arrest Patients With Targeted Temperature Management

Conditions
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Heart Arrest, Targeted Temperature Management

Intervention / Treatment
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* Diagnostic Test: Multi-channel aEEG monitoring


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Comatose cardiac arrest TTM treatment Multi channel aEEG monitoring Exclusion Criteria: Cerebral origin cardiac arrest Known epilepsy

Ages Eligible for Study
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Minimum Age: 19 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Good neurological outcome<br>CPC 1 and 2 at 6 month after ROSC | Diagnostic Test: Multi-channel aEEG monitoring<br>* 18 channel aEEG monitoring in comatose TTM-treated patients<br>|
| Poor neurological outcome<br>CPC 3 to 5 at 6 month after ROSC | Diagnostic Test: Multi-channel aEEG monitoring<br>* 18 channel aEEG monitoring in comatose TTM-treated patients<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time to normal trace in each aEEG channel | Normal trace was defined as continuous cortical activity on the raw EEG scan; in addition, the upper margin of the aEEG scan, referred to as the aEEG maximum, was >10 μ V, and the lower margin of the aEEG scan, referred to as the aEEG minimum, was >5 μ V. The Time from ROSC to normal trace (TTNT, hours) is predictor of neurological outcome in these patients. We will evaluate the prognostic values of TTNTs in all aEEG channels. | at day 180 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| TTNT threshold for neurologic prognostication in each aEEG channel | Using area under the curve (AUC) of each channel aEEG for neurological outcome, we will determine the best TTNT thresholds for good neurological outcome (CPC 1 to 2) in all aEEG channels. | at day 180 | 
| Alpha delta ratio of each channel aEEG for good neurological outcome (CPC 1 to 2) | The percentage powers in the alpha, theta and delta bands and the ratio of the powers in different frequency bands (i.e., alpha/delta) will be calculated. Finally we will evaluate the prognostic values of these ratios of the different bands. | at day 180 | 
| Comparison of prognostic value between aEEG and various predictors | We will compare the prognostic performances (i.e., sensitivity, specificity, AUC) for poor neurological outcome (CPC 3 to 5) between EEG and these predictors. | at day 180 |