Features Emotional Responses in Adults With Autism: Comparison With Bipolar Disorder (REMBAU)

Study Overview
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Brief Summary
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The objective of this study is to identify the specific characteristics of Autism Spectrum Disorder (ASD) in emotional response profiles and shared with Bipolar Disorder (BD) characteristics.

Official Title
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Features Emotional Responses in Adults With Autism: Comparison With Bipolar Disorder

Conditions
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Autism Spectrum Disorder, Bipolar Disorder

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: For all participants: Age between 18 and 50 years Normal vision (or corrected) Absence of neurological disorder (epilepsy , head trauma, ... ) Ability to understand information about the protocol Informed and signed consent normal mood (euthymia) normal or high intelligence Subjects with ASD: Subjects with an autism spectrum disorder according to the DSM-5 The diagnosis is confirmed by diagnostic interviews: ADI- R (Autism Diagnostic Interview-Revised) and / or ADOS (Autism Diagnostic Observation Schedule ) . Subjects with bipolar disorder: Diagnosis of bipolar disorder according to DSM-IV-TR or DSM -5 The diagnosis is confirmed by the MINI 6.0 (The Mini-International Neuropsychiatric Interview) . Healthy volunteers: Inclusion after checking the national register of healthy volunteers No history of disease of the central nervous system or psychiatric disorder No family history of ASD or BD in the first degree Lack of psychotropic medication or current cardiotropic Lack of psychiatric disorder on Axis I MINI 6.0 AQ Score < 32

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Autism Spectrum Disorder<br>Autism Spectrum Disorder adults without intellectual disability | |
| Bipolar Disorder<br>Bipolar Disorder adults during normothymic phase of illness | |
| Healthy Volonteers<br>Healthy adults | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Physiological emotional response during emotion elicitation in a laboratory session (Pupil size measured by eye tracking, heart rate, electrodermal response, breath rate) during emotion elicitation in a laboratory session |  | average 1 hour | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Subjective emotional response during emotion elicitation in a laboratory session |  | average 1 hour | 
| Facial emotional response during emotion elicitation in a laboratory session |  | average 1 hour | 
| Experience sampling method in real life during a week (emotions, activities, social context, burden) |  | within the first 7 days after inclusion | 
| Physiological emotional response in real life (heart rate, electrodermal response, breath rate, actimetry) |  | within the first 24h approx. after inclusion | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Autism Spectrum Disorder, Bipolar Disorder, Emotions