Saturated Fatty Acids Intake and Mortality, Diabetes, Hypertension and Overweight

Study Overview
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Brief Summary
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The role of saturated fatty acids (SFAs) intake in the development of total death, cardiovascular diseases, diabetes, hypertension and overweight are in great controversy but evidence from large population in China is scant.The investigators aim to use the data from the China Health and Nutrition Survey to assess the long-term association of SFAs intake with total mortality, diabetes, hypertension and overweight.

Detailed Description
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The role of saturated fatty acids (SFAs) intake in the development of total death, diabetes, hypertension and overweight are in great controversy but evidence from large population in China is lacking.The investigators aim to utilize the data from the China Health and Nutrition Survey. The investigators will calculate the cumulative average intake of SFAs based on 3 consecutive 24-h dietary recalls in each round.Sex-specific Cox regression models will be used to estimate the relative risk.Results from our work will be used to provide epidemiological evidence for improving recommendation on SFAs intake for Chinese in dietary guidelines.

Official Title
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Saturated Fatty Acids Intake and Mortality, Diabetes, Hypertension and Overweight in the China Health and Nutrition Survey (CHNS)

Conditions
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Morality, Diabetes, Hypertension, Overweight

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adults aged ≥20 with complete data on diet and follow-up time Exclusion Criteria: Cardiovascular diseases Diabetes (for analyses of diabetes) Body mass index ≥ 24 kg/㎡ (for analyses of overweight) Hypertension (for analyses of hypertension)

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality | Incidence of all-cause death, on basis of household members' report | From baseline until death or censoring on 31 December 2011, whichever came first, assessed up to an average of 10 years | 
| Diabetes | Incidence of diabetes, on basis of self-reported physician diagnosis, fasting plasma glucose ≥ 7.0 mmol/l or HbA1c ≥ 6.5% | From entry into the study (baseline: 1997-2009) until 2011 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Saturated fatty acids intake | Cumulative average intake of saturated fatty acids on basis of 3 consecutive 24-h dietary recalls | From entry into the study (baseline: 1997-2009) until 2011 | 
| Hypertension | Incidence of hypertension, on basis of self-reported physician diagnosis, systolic pressure ≥ 140 mmHg or diastolic pressure ≥ 90 mmHg | From entry into the study (baseline: 1997-2009) until 2011 | 
| Overweight | Incidence of overweight, on basis of body mass index (BMI), BMI ≥ 24 kg/㎡ | From entry into the study (baseline: 1997-2009) until 2011 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Saturated fatty acids, CHNS