Contrast Enhanced Ultrasound of Carotid Plaque in Acute Ischemic Stroke

Study Overview
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Brief Summary
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This is a biomedical, single-center, and prospective study of a consecutive patients cohort in acute ischemic stroke with carotid plaque.

Detailed Description
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The main objective of this study is to evaluate the prevalence of the contrast taking carotid plaques in these acute ischemic strokes. The secondary objectives are: to determine the clinical, sonographic, CT scanner and MRI characteristics of patients in constituted acute cerebral ischemia with carotid atherosclerotic plaque taking contrast to the doppler ultrasound. to explore of the plaque contrast enhancement at 6 months (new injection).

Official Title
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Contrast Enhanced Ultrasound of Carotid Plaque in Acute Ischemic Stroke

Conditions
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Cerebral Infarction

Intervention / Treatment
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* Other: Contrast injection Sonovue®


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All patients aged at least 18 years hospitalized with ischemic stroke signs in the carotid territory, objectified on brain MRI with positive DWI. Carotid plaque > 2.5 mm thickness in the ipsilateral carotid territory to the AIC, low echogenicity (Type 1, 2, 3, and 4a of the classification Geroulakos) measured by the assessment GSM (median gray level). Free and informed consent patient or his representative for contrast injection microbubble. Affiliated to health insurance. Exclusion Criteria: Severe cerebral infarction with NIHSS> 25 No-indications to the contrast medium injection Recent myocardial infarction, unstable angina. Heart failure stage III / IV New York Heart Association. Cardiac shunt left-right, respiratory distress. Allergy to albumin or contrast agents. Carotid plaques and hyperechoic calcified (however these plaques will be counted to determine their prevalence in acute AIC). Carotid dissection

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Acute ischemic carotid stroke<br>Patients hospitalized in the neurovascular intensive care unit for an acute ischemic stroke with a carotid plaque responding to inclusion criteria. These patients receive a contrast injection Sonovue® will be performed during the neck vessels doppler ultrasound. | Other: Contrast injection Sonovue®<br>* In addition to standardized assessment routine care, a contrast injection will be performed during the neck vessels doppler ultrasound.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Contrast enhancement of carotid plaque prevalence in ultrasound doppler |  | Day 1 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patient's demographics data |  | Day 1 | 
| Patient's sonographic and MRI characteristics. | confirmation of the recent character of stroke on the DWI, search for stroke sequelae and white matter disease on the FLAIR, search of the thrombus on the T2*, search occluded artery on the 3DTOF | Day1 | 
| describe the aspect of the carotid plaque on CT angiography. | NASCET stenosis and the aspect (smooth, irregular, ulcerated) | between 1 to 5 days | 
| Persistence , decrease or loss of contrast enhancement in ultrasound doppler. |  | Month 6 | 
| Cerebral infarction recurrence |  | Month 6 |