linjc16/ctgov huggingface dataset:
Exercise Performance in Patients With Atrial Fibrillation

Study Overview
=================
Brief Summary
-----------------
Heart failure and stroke are the two major complication of atrial fibrillation. Current treatment for atrial fibrillation is so focused to stroke prevention, but the risk assessment for heart failure is less highlighted. The most of patients with atrial fibrillation have cardiac functional limitation of variable degree. We hypothesize that the exercise test would reveal the subclinical cardiac dysfunction, and might be helpful to classify the patients with atrial fibrillation according to their exercise capacity real cardiac function.

Official Title
-----------------
Exercise Performance in Patients With Atrial Fibrillation: Usefulness of Cardiopulmonary Exercise Test

Conditions
-----------------
Atrial Fibrillation

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Nonvalvular chronic atrial fibrillation Left ventricular ejection fraction >40% Exclusion Criteria: Acute decompensated heart failure within 30 days unstable hemodynamic status Significant coronary artery disease Any condition interfering sufficient exercise Valvular stenosis or regurgitation of moderate or severe degree Obstructive or restrictive lung disease of moderate or severe degree Active malignancy

Ages Eligible for Study
-----------------
Minimum Age: 30 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Optimal/inappropriate exercise response<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Exercise response patterns of heart rate and oxygen uptake |  | At baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Composite cardiovascular events (all death, admission of heart failure, stroke/thromboembolism) |  | Up to 2 years |
Correlation of Clinical Frailty Scale and Modified Frailty Index in Intensive Care Patients

Study Overview
=================
Brief Summary
-----------------
The purpose of our study is to evaluate the correlation of the Clinical Frailty Scale, which is a judgment-based measure, and the Modified Frailty Index, which interrogates the patient's current diseases, in the frailty assessment of intensive care patients and the effect on the estimation of mortality, mechanical ventilation need, intensive care stay, hospital stay and discharge status.

Official Title
-----------------
Correlation of Clinical Frailty Scale and Modified Frailty Index in Intensive Care Patients

Conditions
-----------------
Frailty

Intervention / Treatment
-----------------
* Diagnostic Test: Clinical Frailty Scale
* Diagnostic Test: Modified Frailty Index


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: intensive care patients Exclusion Criteria: patients with a life expectancy of less than 24 hours Do not speak Turkish

Ages Eligible for Study
-----------------
Minimum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: Clinical Frailty Scale|Clinical fragility scale will be recorded in the first 24 hours of intensive care admissions.|
|Diagnostic Test: Modified Frailty Index|Modified Frailty Index will be recorded in the first 24 hours of intensive care admissions.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Frailty | the correlation of the Clinical Frailty Scale, which is a judgment-based measure, and the Modified Frailty Index, which interrogates the patient's current diseases, in the frailty assessment of intensive care patients | in the first 24 hours of intensive care admissions | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| mortality | effect of the clinical frailty scale and modified farilty index on the estimation of mortality | the patient will be monitored for 1 year and the exitus time will be recorded | 
| intensive care stay | effect of the clinical frailty scale and modified farilty index on the estimation of intensive care stay | the patient will be monitored for 1 year and the intensive care stay will be recorded | 
| discharge status | effect of the clinical frailty scale and modified farilty index on the estimation of discharge status | the patient will be monitored for 1 year and the discharge status will be recorded |
Glucocorticoids and Pulmonary Hypertension

Study Overview
=================
Brief Summary
-----------------
Pediatric idiopathic pulmonary hypertension has significant morbidity and mortality. An ever expanding body of knowledge indicates the important contribution of inflammation to pathogenesis and successful treatment with glucocorticoids. Over the last several years the investigators have utilized steroids in patients with severe pulmonary hypertension as part of a treatment regimen. These basic science studies possibly identifies a biochemical etiology for the development of disease and may also be impacted by the administration of steroids. Additionally, there is a commercially available assay which tests for all of the above molecules.

Official Title
-----------------
Prospective Study of Glucocorticoids as a Mechanism to Treat Pulmonary Hypertension

Conditions
-----------------
Pulmonary Hypertension Due to Lung Diseases and Hypoxia, Pulmonary Hypertension, Bronchopulmonary Dysplasia

Intervention / Treatment
-----------------
* Drug: GlucoCorticoid


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: premature, BPD, >36 wga pulmonary hypertension evidence by echocardiogram Exclusion Criteria: poor ventilation/oxygenation

Ages Eligible for Study
-----------------
Minimum Age: 1 Day
Maximum Age: 5 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: GlucoCorticoid|Administering glucocorticoid|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Echo estimation of RV pressure |  | 5 days |
Serial Electrophysiologic Monitoring During Administration of Nerve-Toxic Chemotherapeutic Drugs

Study Overview
=================
Brief Summary
-----------------
The study hypothesis is that changes in serially obtained nerve conduction study data obtained every 3-4 weeks in cancer patients receiving chemotherapy can be used to predict the development of a clinically significant / disabling drug induced neuropathy six and twelve months following the start of treatment. Patients with breast cancer, colon cancer, gastroesophageal cancer, and non-Hodgkins lymphoma will be enrolled. Six lower extremity nerves--three in each leg--will be electrically stimulated and their responses recorded at three to four week intervals coinciding with patient's scheduled chemotherapy.

Official Title
-----------------
Serial Electrophysiologic Monitoring During Administration of Nerve-Toxic Chemotherapeutic Drugs

Conditions
-----------------
Chemotherapy, Nerve Degeneration, Nerve Conduction

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Clinical diagnosis of untreated breast cancer, treated (advance stage) or untreated colon cancer, untreated non-Hodgkins lymphoma, or advanced gastroesophageal cancer scheduled to begin chemotherapy with either Taxol, oxaliplatin, or vincristine Exclusion Criteria: Individuals with an implanted electronic medical devices (cardiac pacemaker or defibrillator, vagus nerve stimulator, deep brain stimulator, intrathecal pump, others) Individuals whose chemotherapy regimen will include nerve toxic drugs other than Taxol, oxaliplatin, or vincristine, or includes more than one of these three drugs in combination Individuals whose screening nerve conduction studies show peroneal motor amplitude < 1 mV bilaterally or sural sensory amplitude < 3 uV bilaterally or no result obtainable

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time in weeks to fifty percent decrease in sural nerve action potential amplitude |  | one year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
taxol, vincristine, oxaliplatin, chemotherapy, nerve degeneration, nerve conduction, cancer, nerve conduction studies
Cerebrospinal Fluid IL-6, IL-8 and PCT as Early Marker of an Intrathecal Infection in Neurosurgical Patients

Study Overview
=================
Brief Summary
-----------------
The value of CSF IL-6, IL-8 and Procalcitonin in detecting an early diagnosis of intrathecal infection in neurosurgical patients with an external ventricular drainage is evaluated.

Detailed Description
-----------------
The value of CSF IL-6, IL-8 and Procalcitonin in detecting an early diagnosis of intrathecal infection in neurosurgical patients with an external ventricular drainage is evaluated.

Official Title
-----------------
Early Detection of CSF Infection in Neurosurgical Patients

Conditions
-----------------
Intrathecal Infection, External Ventricular Drainage Associated Infection

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: external ventricular drainage informed consent Exclusion Criteria: no informed consent prior intrathecal infection prior systemic infection / sepsis
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| patients<br>patients with an external ventricular drainage | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| increasing IL-6, IL-8 and PCT prior to an clinically apparent intrathecal infection/ a detection with the goldstandard |  | 08/ 2014 - 12/ 2016 |
Effect of Lower Extremity Joint Manipulation on a Lower Extremity Somatosensory Illusion

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to examine the influence of extremity manipulation on individual's center of pressure after they adapt to an ankle based illusion.

Official Title
-----------------
Immediate Effect of Lower Extremity Joint Manipulation on a Lower Extremity Somatosensory Illusion: a Preliminary, Randomized, Controlled Crossover Clinical Trial

Conditions
-----------------
Healthy, Coordination and Balance Disturbances

Intervention / Treatment
-----------------
* Other: chiropractic manual therapy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: No previous surgeries Not knowingly pregnant No neuromusculoskeletal injuries or systemic diseases that could affect an individual's ability to stand on an incline for 3 minutes with their eyes closed. Exclusion Criteria: - Weight over the force plate operating limit of 440 lbs

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Intervention<br>Received a bilateral, lower extremity manipulation series | Other: chiropractic manual therapy<br>* high velocity low amplitude thrust into a human joint<br>|
| No Intervention: Control<br>30 seconds of lying supine on a chiropractic bench (control) without manual manipulation | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Center of pressure position | position in centimeters as evaluated by a force plate | baseline, immediately post-intervention, same day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pathlength | cumulative distance traveled by center of pressure during trial | baseline, immediately post-intervention, same day | 
| RMS | (Root mean square) measure of amplitude of center of pressure during trial | baseline, immediately post-intervention, same day | 
| Mean velocity | average speed and direction of center of pressure during trial | baseline, immediately post-intervention, same day |
Acupuncture Compared With Sham Acupuncture for Treatment of Chronic Neck Myofascial Pain

Study Overview
=================
Brief Summary
-----------------
In order to investigate the therapeutic effect of acupuncture on chronic neck myofacial pain syndrome, the investigaotrs designed a pilot study of a single-blind randomized controlled trial. A total of 34 chronic neck myofacial pain syndrome patients were selected from Department of Neurology of Nantou Hospital, Department of Health. The age ranged from 18 to 85, and all subjects were full informed consent and volunteers. They were divided into two groups of 17 subjects randomly as follows: acupuncture group, acupuncture stainless needles were inserted into bilateral Fenhchi, Jianliao and Houxi acupoints, respectively. The acupuncture needles then were manual twist and de Qi, and remain for 20 min; sham acupuncture group, the methods were identical the acupuncture group, but acupuncture stainless needles were inserted into subcutaneous tissue only. All the subjects were treated with acupuncture two times per week and continuously three weeks, i.e. Six times acupuncture treatment. The therapeutic effect of acupuncture was assessed before and finishing six times acupuncture treatment, and four weeks and twelve weeks after stopping acupuncture, respectively. The index of acupuncture therapeutic effect was according to the range of motion (ROM) of the cervical spine, the intensity of pain (Short-Form McGill Pain Questionnaire; SF-MPQ) and quality of life (SF-36). The investigators expect acupuncture apply to bilateral Fenhchi, Jianliao and Houxi acupoints may relief the pain and motion of chronic neck facial pain syndrome patient, and also improves the life quality.

Conditions
-----------------
Chronic Neck Myofascial Pain Syndrome

Intervention / Treatment
-----------------
* Device: acupuncture


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 18-85 year-old patients with neck myofascial pain for more than one month; not received any treatment in the two weeks before participating this study Exclusion Criteria: Fracture or surgery of the cervical spine; Cervical radiculopathy or myelopathy; Any rheumatic disorder; Systemic disorders; Major psychiatric disorder, alcoholism or substance abuse; Coagulation dysfunction, or related medicines; Pregnancy; Contraindications to acupuncture; Refused to sign consent

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: acupuncture|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Nicotine as an Adjuvant Analgesic for Third Molar Surgery

Study Overview
=================
Brief Summary
-----------------
Third molar surgery is complicated by pain and swelling for several days after surgery. Non-steroidal antiinflammatory drugs have been useful in combination with opioids for treatment. Nicotine has antiinflammatory and pain relieving properties. We will use nicotine or placebo as a nasal spray before surgery to determine whether nicotine affects pain or inflammation.

Detailed Description
-----------------
This is a randomized double blind cross-over study. In each of two sittings, the third molars on one side of the mouth are removed. In one sitting the subject will receive a nicotine nasal spray (3mg) and in the other placebo. VAS and narcotic utilization will be compared within patients.

Official Title
-----------------
Effect of Nicotine on Pain After Third Molar Extraction.

Conditions
-----------------
Dental Crowding

Intervention / Treatment
-----------------
* Drug: Nicotine
* Other: Placebo


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: over 18 4 molars to be removed Exclusion Criteria: pregnant lactating chronic pain narcotic use asthma ex-smokers

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Nicotine nasal spray<br>In one sitting the subject will receive a nicotine nasal spray, 3 mg, one application. | Drug: Nicotine<br>* Nicotine nasal spray 3mg x 1 before surgery<br>* Other names: Nasal spray, nicotine;|
| Placebo Comparator: Placebo spray<br>In one sitting the subject will receive a placebo nasal spray (0 mg), one application. | Other: Placebo<br>* Placebo nasal spray 0mg x 1 before surgery<br>* Other names: Nasal spray, placebo;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain Reported by Patient | Pain reported on the numerical rating scale for pain (NRS) with 0=no pain and 10=worst pain. | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Nausea |  | 5 days | 
| hydrocodone5 mg/Acetaminopgen 325 mg Use |  | 5 days | 
| Heart Rate | Heart rate reported in beats per minute (BPM) | 5 days | 
| Systolic Blood Pressure | Systolic blood pressure reported in Millimeters of Mercury (mmHg) | 5 days | 
| Diastolic Blood Pressure | Diastolic blood pressure reported in Millimeters of Mercury (mmHg) | 5 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Third Molar, Pain
Correlation Between Abdominal Wall Stimulation and Neurostimulator Tip Location

Study Overview
=================
Brief Summary
-----------------
In this prospective interventional study, we look at the level of tip of the DTM neurostimulator and the presence of abdominal wall stimulation in patients

Official Title
-----------------
Correlation Between Abdominal Wall Stimulation and Neurostimulator Tip Location

Conditions
-----------------
Neurostimulator; Complication, Neuropathy

Intervention / Treatment
-----------------
* Other: Adjustment of neurostimulator settings


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with a DTM neurostimulator for Failed Back Surgery Syndrome (FBSS) at the thoracic level Exclusion Criteria: Patients younger than 18 years of age Patients who are not able to exercise their will. Inability to understand the Dutch language

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Neurostimulator group<br>Adjustment of neurostimulator settings to see whether or not abdominal stimulation can be provoked | Other: Adjustment of neurostimulator settings<br>* This is an interventional prospective study. After obtaining informed consent, only necessary information will be extracted through the electronic patient record. Through post-operative imaging, a level determination of the neurostimulator tip will be done. During general consultations, patients will be asked if they experienced abdominal wall stimulation after the procedure and when (YES/NO, NRS). This will include looking at the settings of the neurostimulator. And its adjustments. Furthermore, general epidemiological characteristics such as age, gender, height, weight will be extracted from the electronic patient record. At the consultation, another active programming will take place (in accordance with clinical programming) on the tip of the electrode to check whether it provokes abdominal wall stimulation. This will also be scored YES/NO + NRS. Then the settings will be returned as they were pre-consultation.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Abdominal stimulation | Is abdominal wall stimulation present YES/NO and if so what is the score between 0 and 10 on an NRS 1-10. This is then correlated to the position of the electrode. | up to 15 minutes after start of the intervention |
Adjunctive Local Application of Lidocaine During Scleral Buckling Under General Anesthesia

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate the effect of topical lidocaine in scleral buckling surgery.

Conditions
-----------------
Retinal Detachment

Intervention / Treatment
-----------------
* Drug: lidocaine


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Retinal detachment Retinal tear less than 3 hour clock Exclusion Criteria: Vitreous hemorrhage Proliferative vitreoretinopathy

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: lidocaine<br> | Drug: lidocaine<br>* to evaluate the effect of lidocaine on oculocardiac reflex during the surgery<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| intraoperative heart rate measurement |  | 6 month | 
| decrease in pain and nausea,vomiting after surgery |  | 6 month | 
| decrease in ocr after application of topical lidocaine |  | 6 month | 
| postoperative nausea and vommitting |  | 6 month | 
| postoperative pain |  | 6 month |