The Predicted Potential of Quantitative T Cell Repertoire(TCR) in Anti-PD-L1 Treatment in NSCLC Patients

Study Overview
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Brief Summary
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This study is designed to evaluate the predicted potential of quantitative T cell repertoire (TCR) of T cell receptor chains using next-generation sequencing (NGS) in the treatment of the anti-programmed death-ligand 1 (PD-L1) antibody atezolizumab in participants with locally advanced or metastatic NSCLC who have progressed during or following a platinum-containing regimen. Treatment may continue until disease progression or unacceptable toxicity.

Official Title
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The Predicted Potential of Quantitative T Cell Repertoire(TCR) Analysis Using Next-generation Sequencing (NGS) in Anti-PD-L1 Treatment in Non Small Cell Lung（NSCLC) Cancer Patients

Conditions
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Non-Small Cell Lung Cancer

Intervention / Treatment
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* Drug: Atezolizumab (MPDL3280A)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Histologically documented, locally advanced or metastatic NSCLC Representative formalin-fixed paraffin-embedded (FFPE) tumor specimens available or at least 12 unstained, freshly cut serial sections with associated pathology report that are evaluable for PD-L1 expression and epidermal growth factor receptor (EGFR) mutation status prior to enrollment, except for known sensitizing EGFR mutations in which case 10 unstained slides are required and there is no need for central testing of EGFR mutation status Disease progression during or following treatment with a prior platinum-containing regimen for locally advanced, unresectable, inoperable, or metastatic NSCLC, or disease recurrence within 6 months of treatment with a platinum-based adjuvant and/or neoadjuvant regimen or combined modality with curative intent Measurable disease per RECIST Version 1.1 Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 Life expectancy greater than or equal to (>/=) 12 weeks Adequate hematologic and end organ function Agreement to remain abstinent or use contraceptive methods among women of childbearing potential or male partners of women of childbearing potential Recovery from all acute toxicities from previous therapy Exclusion Criteria: Active or untreated central nervous system (CNS) metastases Spinal cord compression not definitively treated or not clinically stable Leptomeningeal disease Uncontrolled pleural or pericardial effusions or ascites requiring recurrent drainage Uncontrolled tumor-related pain Uncontrolled hypercalcemia Malignancies other than NSCLC within 5 years prior to randomization, except for those curatively treated with negligible risk of metastasis or death Pregnant or lactating women Significant cardiovascular, pulmonary, or autoimmune disease Severe infection or major surgery within 4 weeks, or antibiotic treatment within 2 weeks prior to randomization Prior treatment with or hypersensitivity to study drug(s) or related compounds Inability to discontinue strong cytochrome P450 (CYP) 3A4 inhibitors Prior allogeneic bone marrow or solid organ transplant Known PD-L1 expression status from other clinical studies Positive human immunodeficiency virus (HIV) or hepatitis B or C Receipt of a live attenuated vaccine within 4 weeks prior to randomization Treatment with systemic immunomodulators within 4 weeks or five half-lives (whichever is shorter) prior to randomization Treatment with systemic corticosteroids within 2 weeks prior to randomization

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Atezolizumab (MPDL3280)<br>Atezolizumab 1200 milligrams (mg) will be administered via intravenous (IV) infusion on Day 1 of each 21-day cycle until disease progression, death, unacceptable toxicity, withdrawal of consent, or study termination by sponsor, whichever occurs first. | Drug: Atezolizumab (MPDL3280A)<br>* anti-programmed death-ligand 1 (PD-L1) antibody<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| T cell repertoire | Change of T cell receptor repertoire during Anti-PL-L1 treatment. | From Screening until disease progression, death, or loss to follow-up (up to approximately 3 years overall) |