Post COVID19 Functional and Cognitive Assessments

Study Overview
=================
Brief Summary
-----------------
The main objective of the proposed study is to evaluate the impact of coronavirus (2019-nCoV), hereafter COVID -19, on patients' loss of functional capacity after completion of hospital treatment. Specifically, the research will focus on examining changes in musculoskeletal, cardiovascular, and respiratory function, as well as motor control. In addition, we aim to evaluate rehabilitation treatments after recovery from COVID -19 and consider additional preventive measures based on previous experience.

Detailed Description
-----------------
The combination of such a severe respiratory disease as COVID -19 with motor inactivity could have very serious consequences for a person's general health even after COVID -19 symptoms have subsided. To date, the effects of COVID -19 on individual muscle status have not been extensively studied. Therefore, the main objective of this study will be to evaluate the muscle status of patients after COVID -19. In addition, we will be interested in longitudinal monitoring of individuals' rehabilitation, where they will receive instructions based on measured outcomes at hospital discharge. We will also be interested in considering additional preventive measures for future patients based on previous experience of infected and hospitalized COVID -19 patients.

Official Title
-----------------
Vpliv COVID19 na Izgubo Funkcionalnih zmožnosti Pacientov po zaključenem bolnišničnem Zdravljenju The Effect of COVID19 on the Loss of Functional Capacity of Patients After Hospitalization

Conditions
-----------------
Covid19, Respiratory Disease, Walking, Difficulty, Cognitive Decline

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Completed hospital treatment after a positive COVID-19 test Signed written consent Exclusion Criteria: Still testing positive for COVID -19 at discharge. Severe musculoskeletal injuries (e.g., disability). Inability to follow instructions when performing the test.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 100 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Timed up and go test (TUG) | Functional performance of the patients from sitting to standing, walking and turning | Change in time on TUG between both assessment points (pre- to 2 months post-measurement) | 
| Pulse wave velocity (PWV) | Measuring endothelium function in supine | Change in PWV between both assessment points (pre- to 2 months post-measurement) | 
| Spirometry | Measurement of lung function, specifically the forced vital capacity (FVC) | Change in FVC (%) between both assessment points (pre- to 2 months post-measurement) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Walking velocity | measurement of gait velocity on the 4m path. | Change in gait velocity between both assessment points (pre- to 2 months post-measurement) | 
| Trail making test B | Measurement of executive control using the TMT B test | Change in time to solve the TMT B test between both assessment points (pre- to 2 months post-measurement) | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
COVID19, functional outcomes, respiratory function