linjc16/ctgov huggingface dataset:
Relationship Between Postoperative Delirium and Heart Function in Valvular Surgery

Study Overview
=================
Brief Summary
-----------------
Delirium is an acute brain lesion characterized by abnormalities of consciousness, attention, cognition and sensation. Many brain diseases such as stroke, traumatic brain injury and intracranial hypertension can lead to cardiac insufficiency, arrhythmia and heart failure. The incidence of postoperative delirium in patients undergoing cardiac surgery is high. Postoperative delirium is a manifestation of brain function injury. The effect of postoperative delirium on postoperative cardiac function in patients undergoing cardiac surgery is worthy of further discussion.

Official Title
-----------------
Relationship Between Postoperative Delirium and Heart Function in Valvular Surgery：A Prospective Observational Cohort Study

Conditions
-----------------
Valvular Surgery

Intervention / Treatment
-----------------
* Other: No intervention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients undergoing valvular surgery Age between 60 to 75 Exclusion Criteria: Have a history of cerebral infarction before operation Cardiac function was seriously impaired before surgery Neuropsychiatric disorders were present before surgery

Ages Eligible for Study
-----------------
Minimum Age: 60 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| The group with delirium<br> | Other: No intervention<br>* No intervention<br>|
| The group without delirium<br> | Other: No intervention<br>* No intervention<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| heart function | Doses of norepinephrine, epinephrine, dopamine, dobutamine and vasopressin | up to 60 days |
Immune Tolerance Dysfunction in Pregnancy Due to Ambient Air Pollution Exposure

Study Overview
=================
Brief Summary
-----------------
The purpose of this project is to study the effects of air pollution toxicants on pregnant mothers' immune health during and after pregnancy. Using already collected samples, this study proposes to evaluate changes in immune function in response to air pollution with the use of innovative technologies, to identify the drivers of immune dysfunction and potential modifiable factors, and to determine how these immune findings are associated with pollution exposure and outcomes of disease.

Official Title
-----------------
Immune Tolerance Dysfunction in Pregnancy Due to Ambient Air Pollution

Conditions
-----------------
Air Pollution, Pregnancy

Intervention / Treatment
-----------------
* Other: There is no intervention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Pregnant women: at 18-25 weeks gestation at time of eligibility screening and baseline visit Exclusion Criteria: Having smoked more than 50 cigarettes during pregnancy A history of autoimmune diseases, HIV or cancer

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Pregnant women- high level pollution<br>Exposed to high levels of pollution (PM2.5) | Other: There is no intervention<br>* There is no intervention<br>|
| Pregnant women- low level pollution<br>Exposed to low levels of pollution (PM2.5) | Other: There is no intervention<br>* There is no intervention<br>|
| Non-pregnant women-high level pollution<br>Exposed to high levels of pollution (PM2.5) | Other: There is no intervention<br>* There is no intervention<br>|
| Non-pregnant women-low level pollution<br>exposed to low levels of pollution (PM2.5) | Other: There is no intervention<br>* There is no intervention<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Difference in immune cell subset identity and function in pregnant vs. non pregnant women exposed to high vs. low pollution over time |  | 3 years | 
| Identify the epigenetic molecular mechanisms driving immune dysfunction in pregnancy vs. no pregnancy with high vs. low PM2.5 exposure over time |  | 3 years | 
| Map T cell receptor diversity to immune dysfunction in pregnancy vs non pregnancy with high vs. low PM2.5 exposure over time |  | 3 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
immune function
The Monocyte Subsets in Obese Patients With and Without Metabolic Syndrome

Study Overview
=================
Brief Summary
-----------------
Obesity is associated with a chronic low-grade inflammation characterized by macrophage infiltration in adipose tissue that induces insulin resistance and the appearance of metabolic syndrome (MS). The aim of the study was the investigation of whether circulating monocyte subsets are differentially regulated in MS.

Official Title
-----------------
The Investigation of the Role of Inflammation in the Insulin Resistance Syndrome: The Monocyte Subsets in Obese Patients With and Without Metabolic Syndrome

Conditions
-----------------
Obesity, Metabolic Syndrome

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: - Exclusion Criteria: Age less than 18 years old, pregnancy, breast feeding, kidney disease, liver disease, gastrointestinal disease, malignancy, any endocrine disorder or metabolic disease, other than obesity or type 2 diabetes mellitus (T2DM), alteration of body weight (BW) by up of 5% of the initial BW during the last 3 months, any state of stress or systemic inflammation and taking any of the following drugs, within 3 weeks prior to the start of the study: hypolipidemic agents, antidiabetics, drugs for weight loss, nonsteroidal antiinflammatory drugs, glucocorticoids.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Lean<br>Individuals with Body Mass Index (BMI) = 18.5 - 25.0 Kg/m2 | |
| Obese with MS<br>Individuals with BMI ≥ 30.0 Kg/m2 and metabolic syndrome (MS) MS was defined as the presence of three or more of the following criteria: 1) waist circumference ≥ 102 cm in men and ≥ 88 cm in women, 2) serum triglycerides ≥ 150 mg/dL, 3) high density lipoprotein-cholesterol (HDL-C) < 40 mg/dl in men and < 50 mg/dl in women, 4) systolic blood pressure (SBP) ≥ 130 mmHg or diastolic blood pressure (DBP) ≥ 85 mmHg or antihypertensive drug treatment, 5) fasting glucose ≥ 100 mg/dL | |
| Obese without MS<br>Individuals with BMI ≥ 30.0 Kg/m2 but not MS | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Monocyte subsets | Absolute blood count of classical (Mon1A), intermediate (Mon2A) and nonclassical (Mon3A) monocyte subsets wil be measured by flow cytometry. | Baseline measurement | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Obesity, Metabolic Syndrome, Monocyte subsets
Glycemic Response After Palaeolithic-type Meals

Study Overview
=================
Brief Summary
-----------------
The objective of the study is to show post-prandial benefits of Palaeolithic-type meals as compared to a meal constructed along the lines of the WHO dietary recommendations.

Detailed Description
-----------------
The effects of this set of meals will be assessed with respect to blood blood glucose plasma insulin satiety scores plasma gut hormones It is hypothesised that lower post prandial blood glucose concentration, a lower insulin response and increased satiety will be seen after the Palaeolithic meals compared with a reference meal

Official Title
-----------------
Glycemic Response After Two Palaeolithic-type Meals Compared to a Modern-type Meal Composed According to WHO Guidelines

Conditions
-----------------
Glycemic Index of a Meal

Intervention / Treatment
-----------------
* Other: Palaeolithic meal 1
* Other: Palaeolithic meal 2
* Other: Reference meal


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: male ≥ 18 and ≤ 60 years old Body mass index (BMI) ≥ 18 and ≤ 27.0 kg/m2 Apparently healthy Not smoking A fasting blood glucose value within the normal reference value Exclusion Criteria: - No prescribed medication

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Palaeolithic-type meal 1<br> | Other: Palaeolithic meal 1<br>* Based on estimated ratios for protein, fat and carbohydrates that are typical of Hunter-Gatherers and does not contain ingredients that were not available in pre-neolithic times<br>|
| Experimental: Palaeolithic-type meal 2<br> | Other: Palaeolithic meal 2<br>* Based on WHO dietary guidelines for protein, fat and carbohydrate but does not contain ingredients that were not available in pre neolithic times<br>|
| Placebo Comparator: The reference meal<br> | Other: Reference meal<br>* Based on WHO dietary guidelines for protein, fat and carbohydrate.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood glucose | positive incremental area under the concentration versus time | 0-2 hours | 
| Plasma insulin | net incremental area under the curve | 0-2 hours | 
| Peak blood glucose | maximal blood glucose value | 0-2 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Satiety scores | area under the curve | 0-2 hours | 
| Gut hormone panel | Average concentration over time | 0-3 hours | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
glucose, insulin, post prandial
Safety and Pharmacokinetic Characteristics of DP-R206 in Healthy Adult Volunteers

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is compare the pharmacokinetic characteristics of DP-R206 (150mg Ibandronate / 24,000 IU Vitamin D3 complex tablet, qd) and Bonviva (150mg Ibandronate, qd) after oral administration in healthy adult volunteers.

Detailed Description
-----------------
The number of patient is eighty-four. Patients were randomly assigned either a Bonviva tablet(150mg Ibandronate, qd) first, DP-R206(150mg Ibandronate / 24,000 IU Vitamin D3 complex tablet, qd) Second or DP-R206(150mg Ibandronate / 24,000 IU Vitamin D3 complex tablet, qd) first, Bonviva tablet(150mg Ibandronate, qd) second.

Official Title
-----------------
Randomized, Open-label Crossover Study to Evaluate Comparative Pharmacokinetics of Ibandronate Between DP-R206(150mg Ibandronate / 24,000 IU Vitamin D3 Complex Tablet) and a 150mg Ibandronate Tablet in Healthy Adult Volunteers

Conditions
-----------------
Healthy

Intervention / Treatment
-----------------
* Drug: bonviva


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 20 to 55 years of healthy volunteers Exclusion Criteria: Hypersensitivity Reaction about Ibandronate or other drugs(aspirin, antibiotics)

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 55 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Bonviva<br> | Drug: bonviva<br>* 150mg Ibandronate once a month<br>* Other names: bonviva : B1184B01;|
| Experimental: DP-R206<br> | Drug: bonviva<br>* 150mg Ibandronate once a month<br>* Other names: bonviva : B1184B01;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Composite of pharmacokinetics | Cmax, AUClast | predose, 0.25, 0.5, 0.75, 1, 2, 3, 4, 6, 8, 10, 24, 32, 48, 72, 120 hours post-dose | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Composite of pharmacokinetics | AUCinf, tmax, t½β | predose, 0.25, 0.5, 0.75, 1, 2, 3, 4, 6, 8, 10, 24, 32, 48, 72, 120 hours post-dose |
SPECT-CT for Assessment of Total Knee Arthroplasty in Navigated and Non-navigated Total Knee Arthroplasty

Study Overview
=================
Brief Summary
-----------------
By the comparison of two operation methods navigated and non-navigated TKR with SPECT/CT we want to show wich method has the better outcome.

Detailed Description
-----------------
With SPECT/CT we want to controll the clinical outcome of patients who underwent a navigated or a non-navigated TKR.

Official Title
-----------------
SPECT-CT for Assessment of Patients Before and After Navigated and Conventional Total Knee Arthroplasty.

Conditions
-----------------
Osteoarthritis, X-rays; Effects

Intervention / Treatment
-----------------
* Procedure: TKR


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Total Knee prosthesis (primary) >18 years Exclusion Criteria: pregnancy lactating women endocrine diseases tumour diseases posttraumatic osteoarthritis of the knee previous infection of the knee medicaments which influence the metabolism of the bone

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| SPECT/CT before/after navigated TKR<br>SPECT/CT in patients before and after navigated TKR (assessment of bone tracer uptake, 3D CT component position) | Procedure: TKR<br>* non-navigated versus computer-navigated total knee replacement<br>|
| SPECT/CT before/after conventional TKR<br>SPECT/CT in patients before and after conventional TKR (assessment of bone tracer uptake, 3D CT component position) | Procedure: TKR<br>* non-navigated versus computer-navigated total knee replacement<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| which operation method is the best in terms of outcome and SPECT/CT imaging |  | five years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Improvement in the post-treatment |  | five years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
total knee arthroplasty, total knee prothesis, Spectrometry, X-Ray Emission, SPECT/CT, measurement of TKA component position
Modified Mallampati Scoring Technique for Airway Assessment

Study Overview
=================
Brief Summary
-----------------
comparing a new technique for airway assessment using tongue depressor versus conventional mallampati scoring system. Using tongue depressor to improve airway score is suggested to increase reliability of airway assessment model

Official Title
-----------------
Modified Mallampati Scoring Technique for Airway Assessment

Conditions
-----------------
Intubation;Difficult

Intervention / Treatment
-----------------
* Device: Tongue depressor group
* Procedure: control group


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: all patients scheduled for elective surgery Exclusion Criteria: known difficult airway trismus cases maxillofacial anomalies

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: D group<br> | Device: Tongue depressor group<br>* using a tongue depressor to assess airway score without tongue protrusion<br>Procedure: control group<br>* airway assessment after tongue protrusion<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| assessment of airway difficulty | correlation between airway score and view during laryngoscopy | before intubation |
Neck Pain in Danish Military Pilots and Flight Crew

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine the prevalence of neck and shoulder pain in Danish fighter pilots, helicopter pilots and helicopter flight crew and to evaluate the effect of a 24 weeks exercise intervention for fighter pilots.

Official Title
-----------------
Neck Pain in Danish Military Pilots and Flight Crew - Environmental Factors With Influence on Performance (PH.D.-Project)

Conditions
-----------------
Neck Pain

Intervention / Treatment
-----------------
* Behavioral: Exercise


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Military fighter and helicopter pilots and crew Active flying 2006 or later Exclusion Criteria: Pilots and crew not active since 2005 or earlier Pilots and crew with other nationality than Danish

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Control<br>Control group | |
| Experimental: Exercise<br>Intervention group | Behavioral: Exercise<br>* Training exercises chosen with background in knowledge of intelligent training<br>* Other names: Training;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Neck pain |  | 1 year | 
| Compliance to training exercises |  | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Muscle strength |  | 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Neck, Pain, Exercise, Pilots, Crew
To Compare Predictive Power of End-tidal Carbon Dioxide Between Different Time Line During Resuscitation

Study Overview
=================
Brief Summary
-----------------
To analyze a multi-center observational study database. to select adult non-traumatic in-hospital cardiac arrest. Review and recored end-tidal carbon dioxide in per minute. Arrange them in different time line. one is in resuscitation time. The other is the time line which the beginning time is the time of starting appearing stable end-tidal carbon dioxide wave.To compare predictive power of end-tidal carbon dioxide between different time line during resuscitation.

Official Title
-----------------
To Compare Predictive Power of End-tidal Carbon Dioxide Between Different Time Line During Resuscitation

Conditions
-----------------
Resuscitation

Intervention / Treatment
-----------------
* Other: predictive power of end-tidal carbon dioxide


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: adult non-traumatic in-hospital cardiac arrest patients Exclusion Criteria:1) surrogate decision of Do-Not-Resuscitate (DNR) during CPR; 2) out-of-hospital cardiac arrest (OHCA) patient; 3) trauma as the main reason for medical treatment; 4) child or adolescent patients; 5) Petco2 value was not recorded effectively; 6) delay from initial CPR to starting to record Petco2 exceeded 30 min; and 7) screening by qualified experts. More than three experienced physicians thought that the patient's Petco2 value was too extreme to agree with his/her medical history, and the value was seen as an error and was excluded

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 100 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| resuscitation time line group<br>The ETCO2 will be arrange in resuscitation time line. | Other: predictive power of end-tidal carbon dioxide<br>* end-tidal carbon dioxide predicts resuscitation outcomes<br>|
| ETCO2 time line group<br>The ETCO2 will be arrange in time line which the beginning time is the time of starting to show stable ETCO2 wave. | Other: predictive power of end-tidal carbon dioxide<br>* end-tidal carbon dioxide predicts resuscitation outcomes<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| predictive power of ETCO2 is week at the beginning of resuscitation | the later predictive power of ETCO2 is better during 30min resuscitation | 1 week |