Chemotherapy and Biological Therapy With or Without Bone Marrow or Peripheral Stem Cell Transplant in Treating Patients With Chronic Myelogenous Leukemia

Study Overview
=================
Brief Summary
-----------------
RATIONALE: Giving chemotherapy, such as hydroxyurea, cytarabine, idarubicin, and etoposide before a donor bone marrow transplant or stem cell transplant helps stop the growth of cancer cells. It also helps stop the patient's immune system from rejecting the donor's stem cells. Interferon alfa may interfere with the growth of cancer cells and slow the growth of cancer. When the healthy stem cells from a donor are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. It is not yet known whether chemotherapy is more effective with or without interferon alfa and/or bone marrow or stem cell transplant in treating patients with chronic myelogenous leukemia. PURPOSE: This randomized phase III trial is studying chemotherapy and biological therapy to see how well it works compared with chemotherapy, biological therapy, and donor bone marrow transplant or autologous stem cell transplant in treating patients with chronic phase chronic myelogenous leukemia.

Detailed Description
-----------------
OBJECTIVES: Compare survival in patients with chronic myelogenous leukemia in early chronic phase treated with allogeneic bone marrow transplantation vs drug treatment with or without autologous peripheral blood stem cell transplantation. Compare survival of patients with late-phase disease treated with high-dose cytarabine vs low-dose cytarabine followed by autografting and interferon alfa maintenance. Compare survival of patients not responding cytogenetically to treatment with continued interferon alfa vs hydroxyurea. Determine frequency, time-point, and duration of hematological and cytogenetic remissions and of Philadelphia chromosome-negative and/or BCR-ABL-positive cells on the various treatments. Correlate the quality of hematological and cytogenetic remissions with survival time in patients treated with these regimens. Compare the course of the terminal phase in patients treated with these regimens. Compare the toxic effects of these regimens in these patients. Determine the effect of prognostic criteria and normal or subnormal WBC on chronic phase duration and survival time in patients treated with these regimens. Compare the effect of early vs late high-dose therapy plus autografting on feasibility, toxicity, and survival times in these patients. OUTLINE: This is a randomized, multicenter study. Patients are stratified according to eligibility for transplantation (yes vs no). All patients undergo cytoreduction comprising hydroxyurea (HU) IV daily. Patients who are ineligible for or refuse transplantation are randomized to 1 of 2 treatment arms. Arm I: Patients receive interferon alfa (IFN) subcutaneously (SC) daily. After 2 weeks of IFN therapy, patients also receive low-dose cytarabine (ARA-C) SC once daily for 10-15 days each month. Patients who do not achieve cytogenetic remission within 12 months continue to receive HU. Arm II: Patients receive IFN SC daily. After 2 weeks of IFN therapy, patients also receive low-dose ARA-C SC daily for 10-15 days each month. Patients who do not achieve cytogenetic remission within 12 months continue to receive IFN therapy SC daily. Patients who are eligible for transplantation with a related donor undergo allogeneic bone marrow transplantation. Patients may receive HU or IFN prior to transplantation. Patients may also receive oral high-dose busulfan daily for 4 days with or without cyclophosphamide or cyclophosphamide with total body irradiation. Patients who are eligible for transplantation but do not have a related donor undergo peripheral blood stem cell (PBSC) harvest and are randomized to 1 of 2 treatment arms. Arm III: Patients receive IFN and low-dose ARA-C as in arm I. Patients who accelerate on treatment may undergo autologous PBSC transplantation. Arm IV: Patients receive idarubicin IV, ARA-C IV over 2 hours, and etoposide IV on days 1-3. Patients then undergo leukapheresis. Beginning on day 8, patients receive filgrastim (G-CSF) SC daily until end of leukapheresis. Patients then receive oral high-dose busulfan daily for 4 consecutive days. The following day, patients undergo reinfusion of autologous PBSC. After blood count recovery, patients receive maintenance IFN 3 times weekly for 8 weeks and then daily. Patients are followed every 3 months for 3 years and then every 6 months thereafter. PROJECTED ACCRUAL: A total of 1,000 patients will be accrued for this study within 5 years.

Official Title
-----------------
Randomized Multicenter Treatment Optimization Study In Chronic Myeloid Leukemia (CML) Interferon-a Vs. Allogeneic Stem Cell Transplantation Vs. High-Dose Chemotherapy Followed By Autografting And Interferon-a Maintainance In Early Chronic Phase

Conditions
-----------------
Leukemia

Intervention / Treatment
-----------------
* Biological: filgrastim
* Biological: recombinant interferon alfa
* Drug: busulfan
* Drug: cyclophosphamide
* Drug: cytarabine
* Drug: etoposide
* Drug: hydroxyurea
* Drug: idarubicin
* Procedure: allogeneic bone marrow transplantation
* Procedure: peripheral blood stem cell transplantation
* Radiation: radiation therapy


Participation Criteria
=================
Eligibility Criteria
-----------------
DISEASE CHARACTERISTICS: Diagnosis of chronic myelogenous leukemia in chronic phase Previously untreated Patients negative for Philadelphia chromosome and BCR-ABL translocation must fulfill at least 1 of the following criteria: Impaired health status with reduced exercise tolerance Spleen-related symptoms in cases of splenomegaly Weight loss greater than 10% in 6 months Fever greater than 38.5 degrees C on 5 consecutive days Clinically relevant bone pain Leukocytosis greater than 5,000/mm^3 Thrombocytosis greater than 100,000/mm^3 PATIENT CHARACTERISTICS: Age: Any age Performance status: Not specified Life expectancy: Not specified Hematopoietic: See Disease Characteristics Hepatic: Not specified Renal: Not specified Other: No other concurrent malignancy that is likely to require treatment during study or that is likely to reduce life expectancy No severe concurrent disease or other cause that would preclude study Not pregnant PRIOR CONCURRENT THERAPY: Biologic therapy: No prior interferon Chemotherapy: No prior chemotherapy Endocrine therapy: Not specified Radiotherapy: No prior radiotherapy Surgery: Not specified
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized


Arms and Interventions

| Intervention/Treatment |
| --- |
|Biological: filgrastim|nan|
|Biological: recombinant interferon alfa|nan|
|Drug: busulfan|nan|
|Drug: cyclophosphamide|nan|
|Drug: cytarabine|nan|
|Drug: etoposide|nan|
|Drug: hydroxyurea|nan|
|Drug: idarubicin|nan|
|Procedure: allogeneic bone marrow transplantation|nan|
|Procedure: peripheral blood stem cell transplantation|nan|
|Radiation: radiation therapy|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Survival |  |  | 
| Frequency, time-point, and duration of hematologic and cytogenetic remissions and of Philadelphia chromosome-negative and/or BCL-ABL-positive cells |  |  | 
| Correlation of quality of hematological and cytogenetic remission with survival time |  |  | 
| Course of the terminal phase |  |  | 
| Toxicity |  |  | 
| Effect of prognostic criteria and normal or subnormal WBC on chronic phase duration and survival time |  |  | 
| Effect of early vs late high-dose therapy and autografting on feasibility, toxicity and survival times |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
chronic phase chronic myelogenous leukemia, chronic myelogenous leukemia, BCR-ABL1 positive, Philadelphia chromosome negative chronic myelogenous leukemia, childhood chronic myelogenous leukemia, atypical chronic myeloid leukemia, BCR-ABL1 negative