Combined and Isolated Effects of Sleep Deprivation and Alcohol Intake on Exercise Performance in Humans.

Study Overview
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Brief Summary
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Although the effects of acute alcohol intake and sleep deprivation on exercise performance lacks evidence in the literature, in many situations, they occur simultaneously. Once the alcohol affects physiological processes, the processes that occur during sleep can be impaired, such as: suppression of GH release, action of neurotransmitters and neuromodulators in the CNS, changes in the proportion of sleep stages and may lead to suppression of REM sleep. These changes promote a significant functional impairment such as a reduction in alertness and modification in reaction time, which affects the performance of any activity of daily and professional life. However, the combined effects on the physical performance variables, such as aerobic and neuromuscular performance lack of evidence in the literature.

Detailed Description
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Ten subjects were randomized in four situations after familiarization and control situation: (1) alcohol intake combined with sleep normal; (2) alcohol intake combined with sleep deprivation; (3) placebo intake combined with sleep normal and (4) placebo intake combined with sleep deprivation.

Official Title
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Combined and Isolated Effects of Sleep Deprivation and Alcohol Intake on Cardiorrespiratory, Neuromuscular and Hormonal Responses in Healthy Males.

Conditions
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Alcohol Intake, Sleep Deprivation

Intervention / Treatment
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* Other: Alcohol intake
* Other: Sleep deprivation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: - Physical active men Exclusion Criteria: AUDIT questionnaire above 15 points Nocturnal Chronotype Skeletal muscle injuries in upper and lower limb Metabolic and cardiovascular disease

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 30 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Alcohol intake<br>1 g/kg of etanol combined. Beer without alcohol in the same volume will be used to placebo condition. | Other: Alcohol intake<br>* The subjects will be drink beer (with or without alcohol) before sleep intervention (normal sleep and sleep deprivation).<br>Other: Sleep deprivation<br>* One night of sleep deprivation or one night of normal sleep.<br>|
| Active Comparator: sleep deprivation<br>one night of sleep deprivation will be compared to 8h of normal sleep. | Other: Alcohol intake<br>* The subjects will be drink beer (with or without alcohol) before sleep intervention (normal sleep and sleep deprivation).<br>Other: Sleep deprivation<br>* One night of sleep deprivation or one night of normal sleep.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Aerobic Performance | Aerobic performance will be determined through the subject's heart rate | After each sequence, up to 8 hours | 
| Neuromuscular Performance | knee extensor isometric torque | After each sequence, up to 8 hours | 
| Biochemical Responses | Glucose after each situation in the morning | After each sequence, up to 8 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hydration Status | Urine Specific Gravity | After each sequence, up to 8 hours | 
| Profile of Mood States |  | 6 months | 
| Breath Alcohol |  | 6 months |