Characterisation of Circadian Rhythm in Autistic Spectrum Disorder

Study Overview
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Brief Summary
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Autism spectrum disorders (ASDs) are complex neurodevelopmental conditions characterized by deficits in social communication, delay in language and repetitive behaviors. Results from genetic studies reveal one pathway associated with susceptibility to ASDs, which includes synaptic cell adhesion molecules. Among the factors that could modulate this pathway are the genes controlling circadian rhythms. Sleep disorders and low melatonin levels are frequently observed in ASDs. Thus investigator will characterize the circadian rhythms of patients with ASD and search for circadian rhythms genes polymorphisms.

Official Title
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Characterisation of Circadian Rhythm in Autistic Spectrum Disorder : a Clinical, Biochemical and Genetic Study

Conditions
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Autistic Disorder

Intervention / Treatment
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* Other: Autistic functional exploration
* Other: Control functional exploration


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with autistic spectrum disorders At least 6 years old Membership of a social security scheme Informed consent signed by the patient or both holders of parental authority if the subject is a minor, or by a guardian if the subject is under guardianship Exclusion Criteria: Recent sleep symptoms Incapacity to keep rested for 24 hours

Ages Eligible for Study
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Minimum Age: 6 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Autistic Patient<br>50 adults 25 childs | Other: Autistic functional exploration<br>* 50 adults with urinary sample, core body temperature rhythm, Circadian rhythms assessed with actometer 25 childs with urinary sample, Circadian rhythms assessed with actometer<br>|
| Other: Controls<br>50 adults 25 childs | Other: Control functional exploration<br>* 50 adults with urinary sample, core body temperature rhythm, Circadian rhythms assessed with actometer 25 childs with urinary sample, Circadian rhythms assessed with actometer<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Urinary sulfatoxymelatonin secretion |  | The determination will be performed at 14 days ( child) | 
| Urinary sulfatoxymelatonin secretion |  | The determination will be performed at 21 days ( adults) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Core body temperature rhythm |  | The determination will be performed at 5 days (adult) | 
| Circadian rhythms assessed with actometer |  | The determination will be performed at 14 ( child) and 21 days (adult) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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circadian rhythm