Efficacy of Injectable Vitamin C on Accelerating Canine Movement: A Clinical Study

Study Overview
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Brief Summary
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efficacy of the injectable vitamin C to reduce the time of canine traction

Detailed Description
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Objective. The purpose of this study is to investigate the role and efficiency of the locally injected vitamin C in the enhancement of the palatally impacted canine movement. Design. Twelve adult patients with unilateral palatally impacted canines were included in this study. The enrolled patients were randomly allocated into the study groups; control group; orthodontic traction and he test group: orthodontic traction enhanced by intraepidermic vitamin C injection. The study duration was 12 months.

Official Title
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Evaluation of the Effect of Local Injected Vitamin C on Accelerating the Orthodontic Movement of Maxillary Canine Impaction: A Clinical Trial

Conditions
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Palatally Impacted Canines

Intervention / Treatment
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* Drug: vitamin C


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: medically free patient with good to fair oral hygiene (gingivitis may be included) both sexes were included unilateral palatally positioned permenant canines absence of previous orthodontic treatment absence of supernumerary teeth, odontoms, cysts, traumatic injuries the α angle within grade II to III Exclusion Criteria: systemic diseases especially diabetes and bone diseases pregnant and lactating mothers Local causes (smoking, mouth breathing, local trauma and periodontitis).

Ages Eligible for Study
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Minimum Age: 15 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: vitamin C injection<br>orthodontic traction with vitamin C injection | Drug: vitamin C<br>* 25 IU of vitamin C injected intraepidermally for 6-8 visits till eruption achieved<br>* Other names: ascorbic acid;|
| Placebo Comparator: orthodontic traction<br>orthodontic traction without vitamin C injection | Drug: vitamin C<br>* 25 IU of vitamin C injected intraepidermally for 6-8 visits till eruption achieved<br>* Other names: ascorbic acid;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| rate of tooth movement | the achieved movement in millimeters in one year | 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| level of alveolar bone | the level of the interproximal and facial alveolar bone after orthodontic treatment with or without injection | 12 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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vitamin C, palatally impacted canines, intraepidermal injection