Von Willebrand Factor to Predict Postoperative Outcome

Study Overview
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Brief Summary
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vWF is stored in weibel-palade-bodies of endothelial cells as well as alpha-granula of platelets and is released upon their activation. Endothelial cell dysfunction as well as platelet activation often occur in liver disease and portal hypertension, which may lead to an increase in circulating vWF levels. Indeed, multiple studies have reported that liver disease is associated with increased circulating vWF- antigen (vWF-Ag). Furthermore, increased circulating vWF -Ag Levels have been shown to be associated with increased mortality rates in patients with chronic liver disease. Within a prospective evaluation cohort, the investigators were able to document that patients with increased vWF-Ag levels prior to liver resection suffered from an increased incidence of postoperative liver dysfunction and morbidity. Within this prospective multicenter validation study, the investigators now aim to prospectively validate that circulating vWF-Ag prior to liver resection is a valuable marker to predict postoperative clinical outcome.

Official Title
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Preoperative Von Willebrand Factor to Predict Postoperative Liver Dysfunction and Morbidity After Liver Resection

Conditions
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Morbidity, Liver Dysfunction, Mortality, Hospitalisation

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients undergoing liver resection only patients with either hepatocellular carcinoma, cholangiocellular carcinoma or colorectal cancer liver metastasis will be included Exclusion Criteria: inherited coagulopathy age > 85

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| vWF and postoperative Outcome<br>An independent prospective validation cohorts will be obtained from 4 different Institutions: 2 in Vienna , 1 in Salzburg and 1 in Bern | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of Participants with Postoperative Liver Dysfunction | Preoperative vWF-Ag Predicts Postoperative Liver Dysfunction after Liver Resection | 90 postoperative days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of Participants with Postoperative Morbidity | Preoperative vWF-Ag Predicts Postoperative Morbidity after Liver Resection | 90 postoperative days | 
| Number of Participants with Postoperative Mortality | Preoperative vWF-Ag Predicts Postoperative Mortality after Liver Resection | 90 postoperative days | 
| Days of Postoperative Hospitalisation | Preoperative vWF-Ag Predicts Postoperative Hospitalisation after Liver Resection | 90 postoperative days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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vWF, Liver Resection, Liver Dysfunction, Liver Regeneration, Postoperative Outcome