Correlation Intraocular Pressure With Intracranial Pressure

Study Overview
=================
Brief Summary
-----------------
Severe Trauma Brain Injury (TBIs) is a public health problem and monitoring of Intracranial Pressure (ICP) is a determinant key of it prognosis. Within the noninvasive methods to estimate the ICP, the measurement of intraocular pressure has been proposed because of its biological plausibility (proximity of the eye to the encephalic contend). Objective. Correlate intraocular pressure with ICP in children with TBIs and obtain their utility values.

Detailed Description
-----------------
Severe Trauma Brain Injury (TBIs) is a public health problem and monitoring of Intracranial Pressure (ICP) is a determinant key of it prognosis. Within the noninvasive methods to estimate the ICP, the measurement of intraocular pressure has been proposed because of its biological plausibility (proximity of the eye to the encephalic contend). Objective. Correlate intraocular pressure with ICP in children with TBIs and obtain their utility values. Material and methods. Correlation and diagnostic test design study. Inclusion criteria: children with TBIs admitted to the emergency room and indication of catheter for ICP measurement. Exclusion criteria: injury or ophthalmic disease, glaucoma, encephalic death. Intraocular pressure was measured with electronic tonometer in both eyes prior to placement of the catheter for ICP measurement. Correlation was estimated with Spearman's Rho. The utility values of the diagnostic test were obtained from an Receiver Operating Characteristic curve.

Official Title
-----------------
Correlation of Intraocular Pressure With Intracranial Pressure in Childs With Severe Trauma Brain Injury

Conditions
-----------------
Intraocular Pressure, Intracranial Pressure Increase, Trauma, Brain, Children, Only

Intervention / Treatment
-----------------
* Diagnostic Test: with intraocular pressure high
* Diagnostic Test: without intraocular pressure high


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Children with severe trauma brain injury (Coma Glasgow Scale smaller than 9 points), who have been admitted to the pediatric emergency room and in whom the treating neurosurgeon has decided to place a catheter for intracranial pressure measurement. Exclusion Criteria: Ocular trauma, brain death, know eye disease, refusal of parents or guardians to participate in the study.

Ages Eligible for Study
-----------------
Minimum Age: 2 Years
Maximum Age: 15 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| With intraocular pressure high<br>Intracranial pressure equal or more than 20 mmHg | Diagnostic Test: with intraocular pressure high<br>* Measurement of intraocular pressure The measurement will be made with a electronic minimum contact tonometer for measuring intraocular pressure immediately before the placement of the invasive catheter for measurement of intracranial pressure.<br>Diagnostic Test: without intraocular pressure high<br>* Measurement of intraocular pressure The measurement will be made with a electronic minimum contact tonometer for measuring intraocular pressure immediately before the placement of the invasive catheter for measurement of intracranial pressure.<br>|
| Without intraocular pressure high<br>Intracranial pressure smaller than 20 mmHg | Diagnostic Test: with intraocular pressure high<br>* Measurement of intraocular pressure The measurement will be made with a electronic minimum contact tonometer for measuring intraocular pressure immediately before the placement of the invasive catheter for measurement of intracranial pressure.<br>Diagnostic Test: without intraocular pressure high<br>* Measurement of intraocular pressure The measurement will be made with a electronic minimum contact tonometer for measuring intraocular pressure immediately before the placement of the invasive catheter for measurement of intracranial pressure.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Intraocular pressure smaller than 20 mmHg | Abscence of increased intraocular pressure (smaller than 20 mmHg) without intracranial pressure smaller than 20 mmHg. | Immediately | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Intraocular pressure equal or more than 20 mmHg | Intraocular pressure equal or more than 20 mmHg with Intracranial pressure equal or more than 20 mmHg | Immediately |