linjc16/ctgov huggingface dataset:
Physical Therapy Components for Maximum TKR Outcome

Study Overview
=================
Brief Summary
-----------------
The overall goal of this study is to identify what Physical Therapy care components are associated with the best patient-reported functional outcome after Total Knee Replacement (TKR) surgery. The investigators are specifically looking at outcomes at 6 and 12 months after surgery.

Official Title
-----------------
Defining Components of Physical Therapy Achieving Maximum Function After Total Knee Replacement

Conditions
-----------------
Knee Replacement, Knee Osteoarthritis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Are scheduled to undergo an elective, unilateral primary total knee replacement due to knee osteoarthritis Will receive outpatient PT from a participating physical therapist. Agree to record their exercise and activity for specific time points in the study. Exclusion Criteria: Total knee replacement scheduled for indications other than OA (e.g., fracture, malignancy, infection, or revision or prior implant) The inability to obtain informed consent due to cognitive conditions. Non-English speakers as the materials used in this project have not yet been tested with non-English speakers Individuals who are not yet adults (infants, children, teenagers) Pregnant women Prisoners

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 99 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Differences in overall functional gain at 6 months | Differences in pre-operative to 6 month post -operative functional gain, using the SF-36 Physical Component Summary (PCS) Score by physical therapy regimen. | 6 month follow-up | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Differences in knee specific functional gain at 6 months | Differences in pre-operative to 6 month post-operative functional gain, using the Knee Injury and Osteoarthritis Outcome Score (KOOS) Activities of Daily Living (ADL) by physical therapy regimen. | 6 month follow-up | 
| Differences in knee performance measures at 6 months | Differences in pre-operative to 6-month post -operative knee performance measures using the Physical Therapy Performance Measures (includes a 5 minute stair climbing exercise, a 6 minute walking exercise and a sit to stand exercise) by physical therapy regimen. | 6 month follow-up |
Exposed Versus Buried Intramedullary K-wires for Pediatric Forearm Fractures

Study Overview
=================
Brief Summary
-----------------
Comparing the rate of complications between buried and exposed intramedullary implants after fixation of pediatric forearm fractures.

Detailed Description
-----------------
comparison between buried and exposed intramedullary k-wire in fixation of pediatric forearm fracture in rate of complications such as infection,malunion,nonunion and refracture.

Official Title
-----------------
Exposed Versus Buried Intramedullary K-wires for Pediatric Forearm Fractures: a Randomized Controlled Trial.

Conditions
-----------------
Forearm Fracture

Intervention / Treatment
-----------------
* Device: buried intramedullary K-wire
* Device: exposed intramedullary K-wire


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age: less than 10 years . Diaphyseal forearm fracture. closed fracture. isolated or combined fracture of forearm. Exclusion Criteria: 1. Patient age: more than 10 years old . 2-open fracture. 3- pathological fracture. 4-patient with medical history (immune compromized patient e.g D.M, cancer on chemotherapy and aplastic anemia). 5- neurovascular injury.

Ages Eligible for Study
-----------------
Minimum Age: 5 Years
Maximum Age: 10 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Screening
Intervention Model: Single Group Assignment
Interventional Model Description: Using of buried and exposed intramedullary k-wire in pediatric forearm fixation.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Pediatric forearm fracture fixed by buried or exposed intamedullary implant<br>compare complication of buried or exposed intamedullary implant | Device: buried intramedullary K-wire<br>* Using of buried kirschner wire in pediatric forearm fixation<br>* Other names: buried intramedullary kirschner wire;Device: exposed intramedullary K-wire<br>* Using of exposed kirschner wire in pediatric forearm fixation<br>* Other names: exposed intramedullary kirschner wire;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| compare the rate of refracture in participants who fixed by buried and exposed K-wire. | comparison between the rate of refractures in participants who fixed by buried and exposed K-wire by follow up every month for six month. | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| compare the rate of infection and malunion in participants who fixed by buried and exposed K-wire. | compare the rate of infection and malunion in participants who fixed by buried and exposed K-wire. | 6 months |
Young Adult Education on Alcohol & Health

Study Overview
=================
Brief Summary
-----------------
The goal of this clinical trial is to test the effectiveness of our brief online program when compared to those who don't complete the program at all.

Detailed Description
-----------------
A total of 300 participants will complete this 6 month study. The study will include a background survey, 5 week monitoring period where participants either complete the brief online program with check-in surveys or check-in surveys only, and follow-up surveys 1, 3, and 6 months later.

Official Title
-----------------
A Technology-based Intervention for Alcohol-related Sexual Risk Behaviors in Young Women

Conditions
-----------------
Sexual Behavior, Alcohol Drinking, Condomless Sex

Intervention / Treatment
-----------------
* Behavioral: Online program


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Assessed as part of screening procedures Exclusion Criteria: Do not want to participate

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 24 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Intervention only<br>This group will complete 4 weeks of the brief online program along with 5 weeks of check-in surveys. | Behavioral: Online program<br>* The online program is 4 weeks and focused on topics such as alcohol and sexual health<br>|
| No Intervention: Assessment only<br>This group will complete 5 weeks of check-in surveys. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Drinking before sex (frequency) | Using items from the Sexual Health Questionnaire, the investigators will assess the frequency of drinking before sex. | Follow up (1 month, 3 month, 6 months) | 
| Drinking before sex (quantity) | Using items from the Sexual Health Questionnaire, the investigators will assess the number of drinks consumed before sex. | Follow up (1 month, 3 month, 6 months) | 
| Condomless sex | Using items from the Sexual Health Questionnaire, the investigators will assess the frequency of condom use during penetrative sex. | Follow up (1 month, 3 month, 6 months) |
Effect of Nutrition Labeling on Fast Food Choices

Study Overview
=================
Brief Summary
-----------------
A study examining menu choices made at fast food restaurants.

Detailed Description
-----------------
To examine the effect of point-of-purchase calorie information and value size pricing on fast food meal choices a randomized 2 × 2 factorial experiment was conducted in which participants ordered a fast food meal from one of four menus that varied with respect to whether calorie information was provided and whether value size pricing was used.

Official Title
-----------------
Effect of Nutrition Labeling on Fast Food Choices

Conditions
-----------------
Healthy

Intervention / Treatment
-----------------
* Behavioral: Menu: calories=yes, value pricing=no
* Behavioral: Menu: calories=yes, value pricing = yes
* Behavioral: Menu: calories=no, value pricing = no


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Must be 16 years old or older Must regularly eat at fast food restaurants Exclusion Criteria: Non-english speakers

Ages Eligible for Study
-----------------
Minimum Age: 16 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Menu: calories=yes, value pricing=no<br>There were calories listed on the menu, but no value pricing was in place. | Behavioral: Menu: calories=yes, value pricing=no<br> <br> |
| Experimental: Menu: calories=yes, value pricing = yes<br>There were calories listed on the menu, AND value pricing was in place. | Behavioral: Menu: calories=yes, value pricing = yes<br> <br> |
| Experimental: Menu: calories=no, value pricing = no<br>Calories were not listed on the menu, and value pricing was not in place. | Behavioral: Menu: calories=no, value pricing = no<br> <br> |
| No Intervention: Menu: calories=no, value pricing = yes<br>CONTROL CONDITION: calories were not listed on the menu, and value pricing WAS in place. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Total Calories of Meal Ordered |  | single study visit | 
| Energy Intake | energy content of meal ordered and consumed. | After meal | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Behavior
Effect of Magnesium Supplement in Early Pregnancy After ICSI

Study Overview
=================
Brief Summary
-----------------
Daily supplement of magnesium after biochemical diagnosis of pregnancy in females pregnant after ICSI and through out 1st trimester

Detailed Description
-----------------
a fall of magnesium levels at 2-3 weeks of gestation. This drop of magnesium concentration is larger following IVF as compared to spontaneous pregnancies. so magnesium supplement start after biochemical diagnosis of pregnancy and throughout the 1st trimester

Official Title
-----------------
Magnesium Supplement in Early Pregnancy After ICSI

Conditions
-----------------
ICSI

Intervention / Treatment
-----------------
* Drug: Magnesium Oxide
* Drug: Placebo Oral Tablet


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age 25_38 years BMI 25_30 females pregnant after ICSI after biochemical diagnosis of pregnancy Exclusion Criteria: females with poor ovarian reserve and poor responders abnormality in uterine cavity detected by hysteroscopic evaluation pre ICSI and not treated hydrosalpinx

Ages Eligible for Study
-----------------
Minimum Age: 25 Years
Maximum Age: 35 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Magnesium supplement<br>90 female pregnant after ICSI after biochemical diagnosis of pregnancy will receive 500 mg magnesium supplement | Drug: Magnesium Oxide<br>* After biochemical diagnosis of pregnancy each participant will receive magnesium plus 500 mg tablet once daily till the end of the 1st trimester<br>* Other names: magnesium plus tablet;|
| Placebo Comparator: placebo<br>90 female pregnant after ICSI after biochemical diagnosis of pregnancy will receive placebo oral tablet | Drug: Placebo Oral Tablet<br>* After biochemical diagnosis of pregnancy each participant will receive placebo tablet once daily till the end of the 1st trimester<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 1st trimesteric abortion | Either spontaneous or missed abortion | 13 week of gestation |
Ovarian Ageing in Type 1 Diabetes Mellitus

Study Overview
=================
Brief Summary
-----------------
In healthy women, early menopause is an event that is associated with the exacerbation of several risk factors of cardiovascular and skeletal disease. The occurrence of an early menopause may have even greater impact in women with type 1 diabetes mellitus (DM-1). A small number of studies has demonstrated that DM-1 patients experience cycle irregularity and menopause at a younger age compared to controls. In addition, initial studies have suggested that also in regular cycling DM-1 women a decreased ovarian reserve status for age is present. The explanation for this early decay in ovarian reserve in DM-1 patients remains unknown. Next to auto immunity, vascular factors may be possible contributors to accelerated ovarian ageing in DM-1 patients. Confirmation of more accelerated ovarian ageing in DM-1 women is urgently needed in view of the added risk factors outlined above. Also, the mechanisms behind the advanced ovarian ageing, with focus on vascular factors, may shed new light on our understanding of the ovarian ageing process per se.

Official Title
-----------------
Ovarian Ageing in Type 1 Diabetes Mellitus: the Role of Vascular Factors

Conditions
-----------------
Type 1 Diabetes Mellitus

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients: females diagnosed with type 1 diabetes mellitus Controls: healthy age-matched female controls Exclusion Criteria: Induced menopause: surgical (premenopausal hysterectomy and/or bilateral ovariectomy), chemo- or radiation therapy, ovarian surgery and irregular menstrual cycles.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| OVADIA 1: serum AMH level |  | Blood withdrawel once at screening | 
| OVADIA 2: Age at menopause |  | Assesed once in questionnaire |
Epidemiology of Respiratory Insufficiency in Critical Care

Study Overview
=================
Brief Summary
-----------------
Acute respiratory failure is a common entity in intensive care units nowadays and is associated with significant morbidity and mortality, thus representing a major health problem. Most of the published epidemiological studies on this condition were performed when modern ventilatory strategies and non-invasive ventilation were not available. Therefore, an actual evaluation on the incidence and outcomes of this syndrome is mandatory. We will perform an observational prospective study of patients admitted with acute respiratory insufficiency in several ICUs in Brazil.

Official Title
-----------------
Epidemiological Study of Patients With Acute Respiratory Failure Admitted to Brazilian Intensive Care Units

Conditions
-----------------
Acute Respiratory Failure

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Need for non-invasive or invasive mechanical ventilation for more than 24 hours in the first 48 hours of admission to the intensive care unit. Exclusion Criteria: Tracheostomized patients Patients admitted to ICUs for monitoring or in post-operatory of non-complicated surgeries. Patients with cancer on terminal stage.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| acute respiratory failure<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| hospital mortality |  | 15 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| incidence of acute respiratory failure |  | 15 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Acute respiratory failure, Acute lung injury, Acute respiratory distress syndrome, Mechanical Ventilation, Non-Invasive Ventilation
Efficiency of 4-aminopyridin (Fampyra) on Gait, Vision, Cognition, Fatigue and Micturation in Patients With Multiple Sclerosis

Study Overview
=================
Brief Summary
-----------------
The aim of the study is to assess improvement in visual evoked potential, cognition, fatigue, micturation and walking impairment under 3 months of Fampyra treatment

Conditions
-----------------
Multiple Sclerosis, EDSS 4-7

Intervention / Treatment
-----------------
* Drug: Fampyra


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All patients who according to the compound's Norwegian prescription guidelines are deemed eligible for the study, i.e. MS patients with impaired walking as determined by an EDSS 4-7. They do not need a past history of optic neuritis, cognitive failure, fatigue or difficulties micturating. Exclusion Criteria: MS patients with contraindications to the compound according to the prescription guidelines. Patients who have been exposed to Fampyra in the past Patients with an MS attack within last 3 months

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Fampyra group<br> | Drug: Fampyra<br>* The will be given as per normal patient treatment plan<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change from baseline in visual evoked potential after 2 weeks and 3 months |  | 5 months |
Radiofrequency in Female Pattern Hair Loss

Study Overview
=================
Brief Summary
-----------------
Pattern hair loss, also called androgenetic alopecia (AGA) is considered the most common cause of hair loss in both males and females affecting approximately 85% of males and 50% of females over 50 years of age.

Detailed Description
-----------------
RF (Radiofrequency) based devices have also been shown to be successful in promoting hair growth, thought to occur through the induction of growth factors in the papillary dermis. Studying the effect of fractional needling radiofrequency in the treatment of female pattern hair loss will pave the way for more treatment options for this common disease.

Official Title
-----------------
Efficacy of Fractional Needling Radiofrequency in Female Pattern Hair Loss, a Randomized Controlled Trial.

Conditions
-----------------
Female Pattern Baldness

Intervention / Treatment
-----------------
* Other: Vivacy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with female pattern hair loss Exclusion Criteria: - Pregnancy and lactation. Bleeding tendency. Cases who received treatment (systemic or topical) in the last 3 months before treatment. Scarring alopecia. Other associated causes of alopecia

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Fractional microneedling radiofrequency<br>Device | Other: Vivacy<br>* Vivacy and minoxidil<br>|
| Active Comparator: Fractional microneedling radiofrequency followed by minoxidil application<br>Device and drug | Other: Vivacy<br>* Vivacy and minoxidil<br>|
| Active Comparator: Minoxidil<br>Topical drug | Other: Vivacy<br>* Vivacy and minoxidil<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical examination by Sinclair scale | Clinical | 3 months |
Study of Effects of Low Level Laser Therapy in the Physical Training and the Muscle Responses in Humans.

Study Overview
=================
Brief Summary
-----------------
The hypothesis of this study is that a chronic program of physical strength training, associates to effects of low level laser therapy (LLLT) can, possibly, provide changes in genic expression of muscle and to promote an enhancement of anaerobic muscle performance in humans.

Official Title
-----------------
Phase 1. Muscle Genic Expression Under Strength Training and Photostimulated by Laser.

Conditions
-----------------
Healthy Young Male Volunteers, Non Athletes, Free of Metabolic Disease, Joint, Bone and Muscles of Lower Limbs Free of Any Disease

Intervention / Treatment
-----------------
* Device: Photon stimulation by low level laser therapy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: healthy young male volunteers; non-athletic physical activity; Body Mass Index (BMI) under 26; no prescription medicine or dietary supplement use (such as muscle mass builders. Exclusion Criteria: metabolic disease; joint, bone and muscles of lower limbs with any disease

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 28 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: LLLT and Physical Strength training in Humans<br> | Device: Photon stimulation by low level laser therapy<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |