linjc16/ctgov huggingface dataset:
Hyperlactatemia During and After Tumorcraniotomy

Study Overview
=================
Brief Summary
-----------------
This study aims to investigate the association between hyperlactatemia and neurological disability, length-of-stay and mortality in patients who undergo tumorcraniotomy. The risk factors that induce lactat accumulation will also be explored.

Detailed Description
-----------------
Hyperlactatemia is a frequent occurrence in brain tumor surgery. The existing studies, however, are all retrospective, reporting varying effects on clinical outcome. One study reported new neurological deficitis, some found an association with extended hospital stay, while others found no association with outcome. It is therefore important to conduct a prospective study of hyperlactatemia in this patientgroup. Participants in this study will follow the standard treatment protocol for tumorcraniotomy, aside from 2-3 additional, perioperative blodgas analyses and 2 standardized measurements of neurological disability.

Official Title
-----------------
Elevated Serum-lactate in Patients With Brain Tumor During and After Elective Craniotomy: an Observational Clinical Study of Postoperative Patient Outcome.

Conditions
-----------------
Hyperlactatemia, Brain Tumor, Surgery, Anesthesia

Intervention / Treatment
-----------------
* Other: Serum-lactate < 2,2 mmol/L
* Other: Serum-lactate >/= 2,2 mmol/L


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age >/= 18 years Must undergo elective tumor craniotomy Understand oral and written Danish Exclusion Criteria: Adults with incapacity Stereotactic biopsy Lack of informed and signed consent to participate in study

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Tumorcraniotomy patients<br> | Other: Serum-lactate < 2,2 mmol/L<br>* Bloodgas analysis every hour from start surgery until recovery ward discharge<br>Other: Serum-lactate >/= 2,2 mmol/L<br>* Bloodgas analysis every hour from start surgery until recovery ward discharge<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Neurological disability | Modified Rankin Scale (Scoring 0-6, high scores meaning worse outcome) | Change from baseline mRS at 30 days after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Length of hospital stay | In days from admission to discharge. | 1 year | 
| Mortality |  | After 30 days, 6 months and 5 years |
Immediate Complications According to Ultrasound-guided Central Venous Catheters Insertion Site: a Non-inferiority Randomized Clinical Trial

Study Overview
=================
Brief Summary
-----------------
Ultrasound (US)-guided central venous catheterization is now considered standard of care according to recent clinical evidence, at least considering jugular vein approach. Recent trials suggested that even US-guided subclavian approach could be more effective that landmark technique. However, studies comparing both sites employing US are still lacking. We, therefore, designed a non-inferiority randomized controlled trial to compare these sites, both using US guidance, according to immediate complications following central venous catheterization.

Official Title
-----------------
Immediate Complications According to Ultrasound-guided Central Venous Catheters Insertion Site: a Non-inferiority Randomized Clinical Trial Comparing Jugular and Subclavian Approaches

Conditions
-----------------
Catheterization, Central Venous, Ultrasonography

Intervention / Treatment
-----------------
* Procedure: Central venous catheterization


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: critically ill patients; central venous access indicated. Exclusion Criteria: cardiac arrest; at least one side of each vein available for insertion; pacemaker insertion; pulmonary artery catheter insertion; non-corrected coagulopathy; thrombolytics in the past 24 hours.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Subclavian<br>Subclavian vein will be individualized and approached by longitudinal incidence, according to previous studies. Skin puncture will be made next to the transducer, lateral to the first rib, maintaining constant visualization of the needle tip. | Procedure: Central venous catheterization<br>* Ultrasound guided central venous catheterization<br>|
| Active Comparator: Jugular<br>Jugular vein will be identified by transverse or longitudinal approach, and skin puncture will be made by transverse or longitudinal incidence, according to operator's preferences. Using transverse approach, the needle will be maintained in a 45 degree angle with the skin, and the insertion site will be exactly the same as the measured distance between asking and jugular vein wall. | Procedure: Central venous catheterization<br>* Ultrasound guided central venous catheterization<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Immediate complications |  | 24 hours |
An Observational Study on The Correlation Between Time of Initiation of Avastin (Bevacizumab) Treatment And Progression-Free Survival in Patients With Metastatic Breast Cancer (CRONOS 2)

Study Overview
=================
Brief Summary
-----------------
This single arm, prospective, observational study will assess the correlation between the time from start of chemotherapy to the start of Avastin (bevacizumab) treatment with progression-free survival in patients with previously untreated metastatic breast cancer. Patients will be followed for up to 12 months after progressive disease occurs.

Official Title
-----------------
The Correlation Between the Moment of Bevacizumab theRapy initiatiOn and the Efficacy in patieNt With Metastatic Breast Cancer Treated With First Line Regimens Based On AvaStin

Conditions
-----------------
Breast Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adult patients, >/=18 years of age Previously untreated metastatic breast cancer Scheduled to start 1st line chemotherapeutic treatment ECOG performance status 0-1 Exclusion Criteria: Any conditions included in contraindication list for Avastin Prior chemotherapy for metastatic breast cancer Adjuvant/neoadjuvant chemotherapy or radio-chemotherapy of non-metastatic malignancy completed <6 months prior to treatment start

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cohort<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between the time from start of chemotherapy to the start of Avastin treatment with progression-free survival |  | 60 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overall survival |  | 60 months | 
| Safety: Incidence of adverse events |  | 60 months |
SpineTRACK Registry - Spinal Outcomes Registry

Study Overview
=================
Brief Summary
-----------------
The Spine TRACK Spinal Surgery Registry is a prospective multi-center observational data collection initiative, to capture clinical and radiographic outcomes in candidates for spine surgery with degenerative, deformity, and traumatic pathologies. As an observational database, there are no initial driving hypotheses, but rather data will be mined to answer unforeseen questions, but which may include broad topics such as comparative effectiveness between and among various surgical treatment options, and/or outcomes in various subgroups of patients such as defined by demographics, comorbidities, indications and symptoms, treatment variables, and/or outcome variables.

Official Title
-----------------
SpineTRACK (Translating Radiographic and Clinical Knowledge) Registry: Outcomes Data Collection in Degenerative, Deformity, and Trauma Patients

Conditions
-----------------
Vertebra; Degeneration, Spinal Trauma, Spinal Deformity

Intervention / Treatment
-----------------
* Procedure: Surgery


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Candidate for spinal surgery
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Degenerative<br>Patients being treated for degenerative spine conditions. | Procedure: Surgery<br>* Patients will receive standard of care surgical treatment dependent on his/her spinal condition.<br>|
| Deformity<br>Patients being treated for a deformity spine condition. | Procedure: Surgery<br>* Patients will receive standard of care surgical treatment dependent on his/her spinal condition.<br>|
| Trauma<br>Patients being treated for a trauma related spine condition. | Procedure: Surgery<br>* Patients will receive standard of care surgical treatment dependent on his/her spinal condition.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To create a database of radiographic and clinical outcome measures of spinal surgery patients to evaluate the efficacy of various procedures for multiple diagnoses. |  | 24 months then annually thereafter |
Evaluation and Further Development of an Artificial Intelligence-based Algorithm for Clinical Decision Support

Study Overview
=================
Brief Summary
-----------------
Invasive mechanical ventilation is one of the most important and life-saving therapies in the intensive care unit (ICU). In most severe cases, extracorporeal lung support is initiated when mechanical ventilation is insufficient. However, mechanical ventilation is recognised as potentially harmful, because inappropriate mechanical ventilation settings in ICU patients are associated with organ damage, contributing to disease burden. Studies revealed that mechanical ventilation is often not provided adequately despite clear evidence and guidelines. Variables at the ventilator and extracorporeal lung support device can be set automatically using optimization functions and clinical recommendations, but the handling of experts may still deviate from those settings depending upon the clinical characteristics of individual patients. Artificial intelligence can be used to learn from those deviations as well as the patient's condition in an attempt to improve the combination of settings and accomplish lung support with reduced risk of damage.

Official Title
-----------------
Retrospective Use of Patient Treatment Data for the Evaluation and Further Development of an Artificial Intelligence-based Algorithm for Clinical Decision Support in Invasive Mechanical Ventilation of Intensive Care Patients

Conditions
-----------------
Invasive Mechanical Ventilation

Intervention / Treatment
-----------------
* Other: Artificial Intelligence-based Decision support


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: • Subjects who are 18 years or older and receive invasive mechanical ventilation for > 4 hours Exclusion Criteria: • Patients receiving one-lung ventilation

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Artificial Intelligence-based Decision support|Decision support to optimise invasive mechanical ventilation settings|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Relative time of same device settings of the health care provider and the IntelliLung algorithm |  | From date of intubation to date of extubation or date of discharge, which ever came first, assessed up to 12 month | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Mechanical ventilation, ventilator-induced lung injury, ARDS, artificial intelligence
Clinical and Radiologic Follow up of Subchondral Fractures of the Glenoid

Study Overview
=================
Brief Summary
-----------------
in this study the investigators will call patients who had Subchondral fractures and treated in our department over the last 20 years. The investigators will evaluate their shoulder function by a questionary, Constant score and radiologic evaluation.

Detailed Description
-----------------
Patient evaluation by: - Physical examination, questionary Constant score: Pain (severe, moderate, mild, non), activity level (sleep affected/sport limitations/daily living limitations/arm positioning) and range of motion (forward flexion/lateral elevation, internal and external rotation). - Radiologic examination: Axial view, Axillary view and Anterior posterior view- to evaluate the level of osteoarthritis by Kellgren Lawrence score and Samilson score.

Official Title
-----------------
Clinical and Radiologic Follow up of Subchondral Fractures of the Glenoid

Conditions
-----------------
Subchondral Fractures of the Glenoid

Intervention / Treatment
-----------------
* Radiation: XR of shoulder


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Any man or women who had subchondral fractures of the glenoid Exclusion Criteria: Pregnant women Children

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Radiation: XR of shoulder|Radiologic examination: Axial view, Axillary view and Anterior posterior view- to evaluate the level of osteoarthritis by Kellgren Lawrence score and Samilson score.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Function disability of the shoulder | The patients will be invited to the clinic where the investigators will examine them and define a constant score that takes in consideration: Pain, Activity level and Range of motion. | 20 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measurement of degenerative changes of the gleno-humeral joint. | The investigators will assess the status of osteoarthrosis of the gleno-humeral joint, this will be measured by the Kellgren Lawrence (0-4) and the Samilson (0-3) scores. | 20 years |
Accuracy of RTE for Evaluating Hepatic Fibrosis in Chronic Hepatitis: a Prospective Multicenter Study

Study Overview
=================
Brief Summary
-----------------
Our study is a prospective multicenter research and the aim is to explore a variety of suitable evaluation indicators and criteria for diagnosis of diffuse liver fibrosis, to get the corresponding diagnosis threshold, with the domestic common pathological S stages as the gold standard.

Official Title
-----------------
Accuracy of Real-time Tissue Elastography for Evaluating Hepatic Fibrosis in Chronic Hepatitis: a Prospective Multicenter Study.

Conditions
-----------------
Chronic Hepatitis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 1. Patient has a history of chronic hepatitis on clinical diagnosis; 2. Patient undergoed liver biopsy during study time. Exclusion Criteria: 1. Patient cannot receive examination due to critical condition; 2. Patient refuse the examination.

Ages Eligible for Study
-----------------
Minimum Age: 5 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Liver Fibrosis Index (LFI) |  | During the examination | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
real-time tissue elastography, hepatic fibrosis
Expression of S100A2 and Trefoil Factor Family Members in Epstein-Barr Virus Related Gastric Cancer

Study Overview
=================
Brief Summary
-----------------
The investigators hypothesize that aberrant hypermethylation of tumour suppressor genes is an important mechanism for Epstein-Barr Virus (EBV) - related gastric carcinogenesis, the promoter hypermethylation status and the expression of S100A2 and TFF1 might be different between EBV-associated gastric cancer (GC) and non EBV-associated GC.

Official Title
-----------------
Expression of S100A2 and Trefoil Factor Family Members in Epstein-Barr Virus Related Gastric Cancer

Conditions
-----------------
Gastric Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Nil Exclusion Criteria: Nil
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Rebuilding Bridges for Homeless Veterans

Study Overview
=================
Brief Summary
-----------------
Pilot study on an intervention called Rebuilding Bridges to help veterans re-engaged with loved ones.

Detailed Description
-----------------
The objective of the proposed project is to examine the feasibility and acceptability of the Rebuilding Bridges intervention, which was designed to help homeless Veterans plan and implement steps to engage friends, family and other loved ones in their lives. The PI and his team will enroll approximately 25-30 Veterans. Veterans will be recruited via provider referral and via advertisements that will be placed in general clinical areas and desks at the Errera Center. The PI will work with the Veterans to create a detailed genogram of family, friends and other supporters in the Veteran's life. This will be followed by a meeting with each Veteran over the course of three 30-minute weekly sessions to help the Veteran identify and engage people listed in their genogram which the Veteran might want to form stronger relationships with. Veterans will also be asked to complete several measures and questionnaires such as housing information, employment, mental health and quality of life.

Official Title
-----------------
Rebuilding Bridges for Homeless Veterans

Conditions
-----------------
Housing Problems

Intervention / Treatment
-----------------
* Other: Rebuilding Bridges


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria Over 18 years old Currently in a VA homeless program Able to provide valid consent Exclusion Criteria Acute psychiatric decompensation requiring inpatient admission or emergency department services within the last month (suicidality, homicidally, mania, psychotic decompensation) Has a conservator
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Intervention Model: Single Group Assignment
Interventional Model Description: Single group design.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Rebuilding Bridges<br>This is a one-group study and the group will receive the Rebuilding Bridges intervention | Other: Rebuilding Bridges<br>* Psychosocial intervention to help veterans re-engage with family members called Rebuilding Bridges, developed for this project.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Social Support | 2-Way Social Support scale and the Multidimensional Scale of Perceived Social Support, which generates a total score from 1 to 7 with higher scores indicating greater social support | 2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Housing status | Nights stayed in own place and nights homeless in the past 60 days, which should total 60 days. | 2 years |
Repetitive Transcranial Stimulation (rTMS) in Post Stroke Dysphagia

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to assess if rTMS on healthy hemisphere at one hertz could improve patients with post stroke dysphagia.

Official Title
-----------------
Effect of Pharyngeal Inhibition Induced by Repetitive Transcranial Stimulation in Post Stroke Dysphagia

Conditions
-----------------
Dysphagia, Stroke

Intervention / Treatment
-----------------
* Device: rTMS
* Device: Placebo rTMS


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: dysphagia first episode of stroke Exclusion Criteria: swallowing disorder before stroke previous episode of stroke MMS < 20 no consent

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: 1<br>Active rTMS | Device: rTMS<br>* effective and active cortical magnetic stimulations<br>|
| Placebo Comparator: 2<br>sham rTMS | Device: Placebo rTMS<br>* non active cortical magnetic stimulation<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Videofluoroscopy and high resolution manometry |  | day 0, day 14, day 30, day45 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
repetitive transcranial stimulation