Gastric Cancer Survival Without Chemotherapy

Study Overview
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Brief Summary
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This study is observational study to analyze the actual overall survival of the patients who did not receive adjuvant chemotherapy after curative gastrectomy for gastric cancer. The investigators developed prediction model for the overall survival of these patients and validated.

Detailed Description
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Adjuvant chemotherapy (AC) after curative gastrectomy is the standard treatment for patients with locally advanced gastric adenocarcinoma in East Asia; however, for various reasons, some patients do not receive this treatment. The aim of this study was to develop a system that reflects the survival rate of patients without AC. A survival prediction model was developed based on the modified staging system and risk factors for overall survival (OS), which were examined using the Cox proportional hazards regression model. The model was validated for the power of prediction and discrimination, compared with the American Joint Committee on Cancer (AJCC) Cancer Staging Manual 8th edition; it was externally validated using an independent dataset. the newly developed survival prediction model improves the accuracy of OS prediction for stage II and III gastric cancer patients without AC after curative gastrectomy.

Official Title
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Development of a Staging System and Survival Prediction Model for Advanced Gastric Cancer Patients Without Adjuvant Treatment After Curative Gastrectomy

Conditions
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Gastric Cancer

Intervention / Treatment
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* Other: No adjuvant chemotherapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: histologically confirmed primary gastric adenocarcinoma curative R0 resection with D2 lymph node dissection pathologic stage II or III gastric cancer Exclusion Criteria: Patients who received neoadjuvant or AC treatment follow-up loss or death within 30 days of surgery completion of total gastrectomy other malignancy within 5 years before gastrectomy

Ages Eligible for Study
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Minimum Age: 19 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Developement set<br>Gastric cancer patients who did not receive adjuvant chemotherapy after curative gastrectomy from 2009 to 2016 at Seoul St.Mary's Hospital | Other: No adjuvant chemotherapy<br>* There is no intervention differences between 2 groups. We analyzed the data of the patients who did not receive adjuvant chemotherapy.<br>|
| Validation set<br>Gastric cancer patients who did not receive adjuvant chemotherapy after curative gastrectomy from 2009 to 2016 at St.Vincent''s Hospital | Other: No adjuvant chemotherapy<br>* There is no intervention differences between 2 groups. We analyzed the data of the patients who did not receive adjuvant chemotherapy.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overall survival | Overall survival of the patients | June-01-2021 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Gastric cancer, Adjuvant chemotherapy, Overall survival, Nomogram, Prediction