Emergency Curative Resection of Colorectal Cancer

Study Overview
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Brief Summary
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The feasibility and efficacy of emergency curative resection of complicated colorectal cancer is still controversial. This prospective study aim is to assess surgical and oncologic outcomes after emergency compared to elective curative resection of colorectal cancer

Detailed Description
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60 consecutive patients presented with complicated colorectal cancer managed by emergency surgery were included and compared to another 155 consecutive patients admitted during the same period with uncomplicated colorectal cancer managed by elective surgery. Both groups were compared regarding curative resection rate, early postoperative mortality and morbidity, 3-years tumor recurrence and survival rates.

Official Title
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Emergency Curative Resection of Colorectal Cancer, Do it With Caution. A Comparative Case Series

Conditions
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Colorectal Cancer, Oncologic Complications and Emergencies

Intervention / Treatment
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* Procedure: Curative resection of colorectal cancer


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All patients presented with Potentially operable colorectal cancer No clinical or radiological evidence of metastatic disease Exclusion Criteria: Patients received preoperative chemoradiation Patients with clinical or radiological evidence of metastatic disease Patients with intraoperative evidence of metastatic disease Patients with intraoperative evidence of irresectable disease Patients with incomplete follow up

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Emergency group<br>Patients presented to emergency by complicated colorectal cancer ( Obstruction, bleeding or perforation) | Procedure: Curative resection of colorectal cancer<br> <br> |
| Elective group<br>Patients presented with uncomplicated colorectal cancer for resection treatment | Procedure: Curative resection of colorectal cancer<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Adequate oncologic resection | Negative resection margins + adequate lymphadenectomy ( Lymph Nodes retrieved > 12) | histopathological assessment of surgical specimens within 2 weeks postoperative | 
| early postoperative mortality after curative resection of colorectal cancer | early death due to cause related to surgery | within 90 days after surgery | 
| early postoperative morbidity after curative resection of colorectal cancer | surgery-related complications | within 90 days after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Tumor recurrence | either local or distant | By the end of the 3 years follow up period | 
| Disease free survival | % of patients survived without recurrence | By the end of the 3 years follow up period | 
| Overall survival | % of all patients survived either with or without recurrence | By the end of the 3 years follow up period | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Complicated colorectal cancer, Curative resection, Surgical and oncologic outcomes