Concurrent Transcranial Direct Current Stimulation and Gait Training in Parkinson's Disease

Study Overview
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Brief Summary
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To investigate the effect of concurrent transcranial direct current stimulation and gait training on gait performance when doing the cognitive dual-task in people with Parkinson's Disease.

Official Title
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The Effect of Concurrent Transcranial Direct Current Stimulation and Gait Training on Gait Performance When Doing the Cognitive Dual-task in People With Parkinson's Disease

Conditions
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Parkinson's Disease

Intervention / Treatment
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* Other: Active tDCS plus gait training
* Other: Sham tDCS plus gait training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosed with idiopathic PD Hoehn and Yahr stages I-III Mini Mental Status Examination (MMSE) score ≧ 24 Could walk 10m independently with or without gait aid Exclusion Criteria: Concurrent medication likely to affect mental performance tDCS contraindication Significant neurological, vestibular, visual disorders or psychiatric illness Musculoskeletal or cardiopulmonary disease Sensory system pathology

Ages Eligible for Study
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Minimum Age: 50 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Active tDCS plus gait training group<br>Participants in Active tDCS plus gait training group will execute Active tDCS on left dorsolateral prefrontal cortex which combined with treadmill, 12 times per week, least 4 weeks. | Other: Active tDCS plus gait training<br>* Participants in experimental group will accept Active tDCS which combined with treadmill<br>|
| Sham Comparator: Sham tDCS plus gait training group<br>Participants in Sham tDCS plus gait training group will executeSham tDCS on left dorsolateral prefrontal cortex which combined with treadmill, 12 times per week, least 4 weeks. | Other: Sham tDCS plus gait training<br>* Participants in control group will accept Sham tDCS which combined with treadmill<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Dual-task walking performance | To evaluate gait parameters while doing dual-task walking | Change from baseline at 4 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Single walking performance | To evaluate gait parameters while doing single walking | Change from baseline at 4 weeks | 
| Trail-making test A & B | To evaluate executive function | Change from baseline at 4 weeks | 
| Stroop color and word test-Chinese version | To evaluate executive function | Change from baseline at 4 weeks | 
| Digit span test | To evaluate executive function | Change from baseline at 4 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Dual task performance, Executive function, Transcrainal direct current stimulation (tDCS)