Perception of Blood Sugar Variations During Physical Activity in Healthy Subjects and Type 1 Diabetes Patients

Study Overview
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Brief Summary
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Type 1 diabetes is an autoimmune disease with absence of insulin secretion. Blood sugar is a physiological variable that reflets for blood glucose concentration. Blood sugar level fluctuates, especially during physical activity. Sports activity would increase insulin sensitivity, improve lifestyle and, by extension, promote glycemic balance. However, glycemic balance will be disturbed by physical activity with higher risk of hypoglycemia and hyperglycemia. Moreover, hypoglycemia and hyperglycemia will impact body functions. Perceptions of blood sugar variations during physical exercise and their influences on sports performance have not been studied, whether in type 1 diabetes patients or healthy subjects.

Detailed Description
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The aim of the study is to evaluate the perception of blood sugar variations in healthy subjects and type 1 diabetes patients during physical activity

Official Title
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Perception of Blood Sugar Variations During Physical Activity in Healthy Subjects and Type 1 Diabetes Patients

Conditions
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Type 1 Diabetes

Intervention / Treatment
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* Other: Physical activity


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Type 1 diabetics diagnosed more than 3 years ago and controlled (an HbA1c of less than 8%) for type 1 diabetes group without diabetes for healkthy group Male Aged 18 to 65 Body Mass Index less than 30 kg/m2 regular running (at least 30 minutes per week and at least one 10-km run per year for the previous 2 years) Agreeing to participate in the study Exclusion Criteria: Physical injury beta blockers treatment

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Type 1 diabetes group<br>type 1 diabetes group: patients with type 1 diabetes | Other: Physical activity<br>* Physical activity: 10 km run on a treadmill<br>|
| Active Comparator: healthy group<br>healthy group : subjects without type 1 diabetes | Other: Physical activity<br>* Physical activity: 10 km run on a treadmill<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| blood sugar | Blood sugar evaluated in g/L via continuous blood glucose measurement | Day 0 | 
| Feeling lucidity | Lucidity, which is a symptom of hyperglycaemia and hypoglycaemia, assessed by visual analog scale (between not at all lucid to completely lucid | Day 0 | 
| Feeling fatigue | hydratation, which is a symptom of hyperglycaemia and hypoglycaemia, assessed by visual analog scale (between no feeling of dehydration to dehydrated | Day 0 | 
| feeling hungry | hungry, which is a symptom of hyperglycaemia and hypoglycaemia, assessed by visual analog scale (between no feeling of hunger to hungry | Day 0 | 
| average speed per kilometer Sports performance | Sports performance evaluated by average speed per kilometer of the 10 km run on a treadmill | Day 0 | 
| total running time | Sports performance evaluated by total running time of the 10 km run on a treadmill | Day 0 | 
| average running speed | Sports performance evaluated by average running speed of the 10 km run on a treadmill | Day 0 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Type 1 Diabetes, blood sugar variations, physical activity