The Standing and Sitting Spino-pelvic Sagittal Alignment in Chinese Population

Study Overview
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Brief Summary
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This study is aimed to demonstrate the standing and sitting spino-pelvic sagittal alignment in Chinese population, then to explore the influence of spinal fusion on the changes when moving from standing to sitting positon.

Official Title
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The Standing and Sitting Spino-pelvic Sagittal Alignment in Chinese Population

Conditions
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Sagittal Alignment

Intervention / Treatment
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* Radiation: whole spine X-ray


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Group 1 90 Healthy Volunteers - age >40 years, no history of neck pain, back pain, or radicular pain in the previous six months, no history of chronic neck or back pain lasting more than three months, no history of spinal disease or surgery, no spinal deformity or lumbar spondylolisthesis, no history of hip or knee arthroplasty or other realignment surgery of the lower extremities, and no history of neuromuscular disorders. Group 2 126 patients Clinical diagnosis of Lumbar degenerative disease Exclusion Criteria: Group 1 90 Healthy Volunteers - pregnant Group 2 126 patients Neuromuscular diseases Arthritis Tumor A previous history of lumbar fusion surgery

Ages Eligible for Study
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Minimum Age: 42 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1 （asymptomatic）<br>the middle-aged and elderly Chinese asymptomatic population who underwent the whole spine X-ray in standing and sitting positions. | Radiation: whole spine X-ray<br>* Group 1 underwent whole spine X-ray in standing and sitting positions.<br>|
| 2 （patients）<br>the patients who underwent posterior lumbar fusion surgery for lumbar degenerative disease has been followed up for three months. | Radiation: whole spine X-ray<br>* Group 1 underwent whole spine X-ray in standing and sitting positions.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Group 2 The sagittal spinal parameters in degrees | The parameters included TPA (T1 pelvic angle,the angle between the line from the axis of the femoral head to the center of T1 and the line from the axis of the femoral head to the midpoint of the S1 endplate), lumbar lordosis (LL,the angle between the upper endplate of L1 and S1), thoracic kyphosis (TK,The angle between the upper endplate of T4 and the lower endplate of T12), pelvic incidence (PI,The angle between the line perpendicular to the midpoint of the sacral plate and the line connecting this to the midpoint of the hip axis), pelvic tilt (PT,The angle between the line from the middle of the sacral plate to the middle of the hip axis and the vertical line), sacral slope (SS,The angle between the sacral endplate and the horizontal line) | 3 months after surgery | 
| Group 1 The sagittal spinal parameters in degrees | The parameters included TPA (T1 pelvic angle,the angle between the line from the axis of the femoral head to the center of T1 and the line from the axis of the femoral head to the midpoint of the S1 endplate), lumbar lordosis (LL,the angle between the upper endplate of L1 and S1), thoracic kyphosis (TK,The angle between the upper endplate of T4 and the lower endplate of T12), pelvic incidence (PI,The angle between the line perpendicular to the midpoint of the sacral plate and the line connecting this to the midpoint of the hip axis), pelvic tilt (PT,The angle between the line from the middle of the sacral plate to the middle of the hip axis and the vertical line), sacral slope (SS,The angle between the sacral endplate and the horizontal line) | 6 months after study started | 
| Group 1 The sagittal spinal parameters in millimeter | SVA (sagittal vertical axis, The offset between the center of C7 and the plumb line drawn from posterosuperior corner of S1) | 6 months after study started | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Group 2 Disability assessed by the Oswestry Disability Index (ODI) | The Oswestry Disability Index (ODI) (0-100) is used to assess disability.Higher scores mean a worse outcome. | 3 months after surgery | 
| Group 2 Back pain assessed by the VAS | The Visual Analog Scale (0-10) is used to evaluate back pain.Higher scores mean a worse outcome | 3 months after surgery | 
| Group 2 Leg pain assessed by the VAS | The Visual Analog Scale (0-10) is used to evaluate leg pain.Higher scores mean a worse outcome. | 3 months after surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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sagittal alignment, sitting, spinal fusion