Exercise-induced Bronchoconstriction Diagnostics: Impact of a Repeated Exercise Challenge Test

Study Overview
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Brief Summary
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The purpose of this study is to increase the knowledge of the possible diagnostic effect of exercise induced bronchoconstriction performing a repeated exercise challenge test.

Detailed Description
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Prior studies have shown that the intensity influences the sensitivity of exercise challenge tests (ECT) and that a heart rate-based protocol does not ensure sufficient exercise intensity to induce bronchoconstriction. It is not common clinical practice to perform a pre ECT to establish maximal heart rate or maximal oxygen uptake. The heart rate formula recommended by ATS (HRmax= 220-age) is usually applied to determine recommended intensity of the ECT. Conducting a second ECT, based on the knowledge of the first test, introduce the possibility to adjust the intensity on an individual basis. In addition, based on clinical experience, patients may seem reluctant to perform maximal the first time they undergo an ECT on a treadmill. The hypothesis is that patients are less reluctant to perform maximal the second time they undergo the test when they are more accustomed to the procedure and the treadmill by itself.

Official Title
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Exercise-induced Bronchoconstriction Diagnostics: Impact of a Repeated Exercise Challenge Test

Conditions
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Exercise Induced Bronchoconstriction

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Referred to Klinikk for allergi og luftveissykdommer Meet at least 3 out of 5 criteria (symptoms related to exercise): Cough during exercise or within 5 minutes after exercise Wheeze during exercise or within 5 minutes after exercise Heavy breathing, expiratory in particular, during exercise or within 5 minutes after exercise (duration 5 minutes or more) Improvement of physical fitness/breath is lacking despite of exercise intensification Chest tightness during or after exercise Patients former diagnosed with-and treated for asthma who have symptoms of EIB are included in the study. Exclusion Criteria: Ongoing respiratory infection or recent respiratory infection, judged by the responsible doctor to be of importance of the result The inability to perform an Exercise challenge test with maximum effort

Ages Eligible for Study
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Minimum Age: 16 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Forced expiratory volume in one second (FEV1) |  | up to 4 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Forced vital capacity (FVC) |  | up to 4 weeks | 
| Forced expiratory flow at 50 % FVC(FEF50%) |  | up to 4 weeks | 
| Fractional exhaled nitric oxide (FENO) |  | up to 4 weeks | 
| Total lung capacity (TLC) |  | up to 4 weeks | 
| Specific airway resistance (sRAW) |  | up to 4 weeks | 
| Specific airway conductance (sGAW) |  | up to 4 weeks | 
| Residual volume (RV) |  | up to 4 weeks | 
| Diffusing capacity (TLCO) |  | up to 4 weeks | 
| Maximum voluntary ventilation (MVV) |  | up to 4 weeks | 
| Breathing reserve (BR) |  | up to 4 weeks | 
| Respiratory exchange ration (RER) |  | up to 4 weeks | 
| Oxygen uptake peak (VO2 peak) |  | up to 4 weeks | 
| Heart rate peak (HR peak) |  | up to 4 weeks | 
| Ventilation peak (VE peak) |  | up to 4 weeks |