Interferential Electrical Stimulation and Vasodilatation in Healthy Individuals

Study Overview
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Brief Summary
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Interferential electrical stimulation (IES) increases local blood flow. It is not known whether increases in blood flow may be caused by inhibition of sympathetic activity, mediated by muscle metaboreflex activity. The purpose of this study was to evaluate the effect of IES on metaboreflex activation in healthy subjects.

Detailed Description
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The study sample consisted of 11 healthy young individuals. All subjects were non-smokers, non-obese and free of any signs or symptoms of disease, as revealed by medical history, physical examination and electrocardiogram at rest and during cardiopulmonary exercise testing. Exclusion criteria were pregnancy, breast-feeding, alcohol or drug abuse, and any medication with potential effects on cardiovascular variables. Subjects were asked not to drink caffeine-containing drinks or exercise for at least 12 and 48 hours, respectively, before the experimental protocols.

Official Title
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Interferential Electrical Stimulation Improves Peripheral Vasodilatation in Healthy Individuals: A Randomized Crossover Study

Conditions
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Decreased Vascular Flow

Intervention / Treatment
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* Device: Interferential
* Device: Interferential Placebo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Subjects are non-smokers non-obese and free of any signs or symptoms of disease Exclusion Criteria: Pregnancy breast-feeding alcohol or drug abuse medication with potential effects on cardiovascular variables

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Interferential<br>The individuals are treated acutely with interferential electrical stimulation (IES) during 30 min, providing a continuous flow of symmetrical rectangular interferential current biphasic pulses using bipolar electrodes with two channels and a slope of 1/5/1. The fixed current is adjusted to 4000 Hz, with the current AMF at 100 Hz and an AMF variation of 25 Hz (25% of AMF). | Device: Interferential<br>* The individuals are treated acutely with IES during 30 min, providing a continuous flow of symmetrical rectangular interferential current biphasic pulses using bipolar electrodes with two channels and a slope of 1/5/1. The fixed current is adjusted to 4000 Hz, with the current AMF at 100 Hz and an AMF variation of 25 Hz (25% of AMF).<br>* Other names: Transcutaenous electrical stimuation;|
| Placebo<br>The same instructions and electrode positions were provided to the placebo, although the equipment did not provide any stimulation current | Device: Interferential Placebo<br>* The same instructions and electrode positions were provided to the placebo, although the equipment did not provide any stimulation current<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Muscle Metaboreflex Reflex | Calf blood flow | Participants will be followed for the duration of metaboreflex activity (up to 30 minutes) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Autonomic Nervous System, Neuromodulation, Blood flow control, Exercise