Effect of Cuff Pressure During Operation on Postoperative Sore Throat

Study Overview
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Brief Summary
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When general anesthesia is performed for surgery, tracheal intubation is performed. In order to ventilate after performing tracheal intubation, air is injected into the cuff attached to the tube to fill the gap between the tracheal tube and the patients's inner surface of trachea. Even though, 20 to 30 cm H2O is known to be the appropriate pressure to prevent air leaks while preventing ischemic damage of tracheal mucosa. So, Researchers want to observe clinical differences in pressure at both ends of the safety zone of the cuff pressure.

Detailed Description
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Patients who are scheduled for elective surgery/ general anesthesia are randomized to two groups. l : cuff pressure - 20cmH2O ll : cuff pressure - 30cmH2O After tracheal intubation with routine method, cuff pressure is continuously monitored with manometer. The anesthesia during surgery is maintained with 0.8 MAC of desflurane and continuous remifentanil. Clinical outcomes (sore throat, hoarseness and postoperative pain) are evaluated after 0 minutes, 2 hours, 4 hours, and 24 hours after surgery.

Official Title
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Effect of Cuff Pressure During Operation on Postoperative Sore Throat

Conditions
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Arthroplasty, Replacement, Hip

Intervention / Treatment
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* Device: cuff pressure


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients undergoing total hip replacement arthroplasty that require general anesthesia Exclusion Criteria: a patient who disagrees with the study tracheal stenosis operation time > 3 hours or < 1 hour 30 minutes difficult airway drug abuse, alcoholism

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: cuff pressure with 20cmH2O<br>continuous monitoring and maintaining cuff pressure with 20 cmH2O during surgery | Device: cuff pressure<br>* maintaining cuff pressure according the groups<br>|
| Other: cuff pressure with 30cmH2O<br>continuous monitoring and maintaining cuff pressure with 30 cmH2O during surgery | Device: cuff pressure<br>* maintaining cuff pressure according the groups<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| postoperative sore throat | Number of participants with postoperative sore throat for postoperative 24 hours | At postoperative 24 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| postoperative hoarseness | Number of participants with postoperative hoarseness for postoperative 24 hours | At postoperative 24 hours | 
| nausea | Number of participants with postoperative nausea for postoperative 24 hours | At postoperative 24 hours | 
| Requirements of analgesics | Number of participants with analgesics use for postoperative 24 hours | At postoperative 24 hours |