Inflammation in an Ultra Endurance Race

Study Overview
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Brief Summary
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The aim of this study is to study the per and post-exertional variations of the pro and anti inflammatory markers during an ultra-endurance race in healthy volunteers.

Detailed Description
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Study per and post-exertional changes in proinflammatory biological (IL1, IL6, TNF alpha, HMG beta1 and CRP) and anti inflammatory parameters (IL4, IL10 and IL13, TGF beta, LPS, lipoproteins, lipids) during an ultra endurance race.

Official Title
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Per Effort Study of Inflammatory Consequences of an Ultra Endurance Race (165km)

Conditions
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Inflammation, Inflammatory Response

Intervention / Treatment
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* Biological: blood sample


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Male older than 18 years, Completion of an ultra-endurance race (distance greater than 50 kilometers) during the 24 months preceding the race. Affiliation or beneficiary of a social security. Exclusion Criteria: Age lower than 18 years, Subjects with a medical history (pulmonary pathology, cardiac, hypertension) or with a significant chronic inflammatory disease observed during the inclusion visit (the day before the race). Female.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Biological: blood sample|Study per and post-exertional changes in proinflammatory biological (IL1, IL6, TNF alpha, HMG beta1 and CRP) and anti inflammatory parameters (IL4, IL10 and IL13, TGF beta, LPS, lipoproteins, lipids) during an ultra endurance race.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Per and post-exertional variations of IL1 during an ultra-endurance race in healthy volunteers. | In this study, the investigators will measure variations of IL1 blood level | Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race | 
| Per and post-exertional variations of IL6 during an ultra-endurance race in healthy volunteers. | In this study, the investigators will measure variations of IL6 blood level | Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race | 
| Per and post-exertional variations of TNF alpha during an ultra-endurance race in healthy volunteers. | In this study, the investigators will measure variations of TNF alpha blood level | Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race | 
| Per and post-exertional variations of HMG beta during an ultra-endurance race in healthy volunteers. | In this study, the investigators will measure variations of HMG beta blood level | Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race | 
| Per and post-exertional variations of CRP during an ultra-endurance race in healthy volunteers. | In this study, the investigators will measure variations of CRP blood level | Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race | 
| Per and post-exertional variations of IL4 during an ultra-endurance race in healthy volunteers. | In this study, the investigators will measure variations of IL4 blood level | Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race | 
| Per and post-exertional variations of IL10 during an ultra-endurance race in healthy volunteers. | In this study, the investigators will measure variations of IL10 blood level | Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race | 
| Per and post-exertional variations of IL13 during an ultra-endurance race in healthy volunteers. | In this study, the investigators will measure variations of IL13 blood level | Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race | 
| Per and post-exertional variations of lipids during an ultra-endurance race in healthy volunteers. | In this study, the investigators will measure variations of lipids blood level | Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race | 
| Per and post-exertional variations of LPS during an ultra-endurance race in healthy volunteers. | In this study, the investigators will measure variations of LPS blood level | Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race | 
| Per and post-exertional variations of lipoprotein during an ultra-endurance race in healthy volunteers. | In this study, the investigators will measure variations of lipoprotein blood level | Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race | 
| Per and post-exertional variations of TGF beta during an ultra-endurance race in healthy volunteers. | In this study, the investigators will measure variations of TGF beta blood level | Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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inflammation, exercise, ultra endurance