Study of microRNAs in the Evolution of Carotid Plaque. Physiopathological and Therapeutic Interest

Study Overview
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Brief Summary
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Carotid stenosis of atherosclerotic origin may be responsible for stroke, which is one of the most important causes of morbidity and mortality in the Western world

Detailed Description
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Carotid stenosis of atherosclerotic origin may be responsible for stroke, which is one of the most important causes of morbidity and mortality in the Western world. The constitution of the atheroma plaque is linked to the deregulation of several biological phenomena, including angiogenesis, adipogenesis, inflammatory response, lipid metabolism and oxidative stress. In addition to its anatomical and physiological characteristics, the notion of plate stability is of paramount importance for clinical implications. This stability depends largely on the biological composition of the plate. A vulnerable or unstable plaque often has a large lipid body consisting of foam cells (macrophages laden with oxidized LDL) with a thin fibrous screed consisting of smooth muscle cells (CML), collagen fibers and extracellular matrix. This plaque is also made up of numerous inflammatory cells including macrophages, rich vascularization and intraplate hemorrhage. Although the cell composition of the unstable plate is still relatively established, its molecular analysis remains little known. The benefit of carotid surgery in asymptomatic patients with stenosis greater than 70% is increasingly controversial given the moderate risk of spontaneous stroke under optimal medical treatment. This annual average risk is less than 5%. Thus, the discovery of an original and innovative biomarker, predictive of plate rupture, would define the patients most at risk, who benefit most from this surgery.

Official Title
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Study of microRNAs in the Evolution of Carotid Plaque. Physiopathological and Therapeutic Interest

Conditions
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miRNAs, Carotid Plaque

Intervention / Treatment
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* Other: Comparing the expression of miRNAs


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Any adult with a carotid thrombo endarterectomy, affiliated to a social security scheme, informed of the study and not opposed to it. Exclusion Criteria: Any person benefiting from an iterative carotid surgery, or refusing to participate in the study, or not being able to express its consent.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Symptomatic patients<br>in the department with carotid plaque Comparing the expression of miRNAs | Other: Comparing the expression of miRNAs<br>* by PCR, in symptomatic and asymptomatic carotid plaques.<br>|
| Asymptomatic patients<br>in consultation with carotid plaque Comparing the expression of miRNAs | Other: Comparing the expression of miRNAs<br>* by PCR, in symptomatic and asymptomatic carotid plaques.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Analysis of the miRNAs | by PCR of the composition of the atheroma plaque | 3 years |