The Accuracy of Modified TTMB in the Spatial Distribution of Prostate Cancer

Study Overview
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Brief Summary
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Investigators plan to use modified TTMB technology to puncture prostate of participants suspected prostate cancer, especially those with the first negative biopsy , but having a rising PSA.Then, Investigators will simulate the spatial distribution of prostate cancer in patients with positive biopsy before radical prostatectomy by way of the TPS software system . And after the radical prostatectomy ,Investigators will simulate the spatial distribution with the help of large tissue slice technique to compare with preoperative simulation ,which to verify the two simulations are consistent.

Detailed Description
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Investigators mainly plan to determine the accuracy of the modified TTMB technology in combination with the TPS system on the location of the tumor space distribution by comparing the two simulation, which is significant for the accurate focal thearpy.

Official Title
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The Study on the Spatial Distribution of Prostate Cancer by Modified Trans-perineal Template-guided Mapping Biopsy

Conditions
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Prostate Cancer

Intervention / Treatment
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* Procedure: trans-perineal template-guided mapping biopsy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 1.Male patients; 2.18 yrs and older, and 90 yrs and younger; 3.Rectal examination reveal prostate nodules; 4.B ultrasound, CT or MRI find abnormal images; 5.PSA>4ng/ml, abnormal f/t ratio and PSAD Exclusion Criteria: Abnormal coagulation function; Severe urinary tract infection; Serious cardiovascular and cerebrovascular disease

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: TTMB for patients<br>give trans-perineal template-guided mapping biopsy for participants suspected prostate cancer | Procedure: trans-perineal template-guided mapping biopsy<br>* new super saturation of prostate biopsy technique<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the spatial distribution based on the biopsy tissue | to simulate the spatial distribution of cancer based on the biopsy tissue contained cancer with the help of TPS system | 2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the spatial distribution based on the large tissue slice technique | to simulate the spatial distribution based on the large tissue slice technique after radical prostatectomy | 2 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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TPS system, trans-perineal template-guided mapping biopsy, prostate cancer, spatial distribution, large tissue slice