Gene Expression Profiles in Predicting Survival of Patients With Head and Neck Cancer

Study Overview
=================
Brief Summary
-----------------
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict survival of patients with head and neck cancer. PURPOSE: This laboratory study is assessing gene expression profiles in predicting survival of patients with head and neck cancer.

Detailed Description
-----------------
OBJECTIVES: Identify gene expression profiles associated with survival by DNA microarray assay analysis using RNA from formalin-fixed paraffin-embedded tissue samples from patients with squamous cell carcinoma of the head and neck treated on clinical trial RTOG-9501. OUTLINE: Formalin-fixed paraffin-embedded tissue samples are analyzed by DNA microarray analysis for gene expression profiling.

Official Title
-----------------
Survival Prediction in HNSCC Based on Gene Expression Profiles From FFPE Tissues

Conditions
-----------------
Head and Neck Cancer

Intervention / Treatment
-----------------
* Genetic: microarray analysis
* Other: laboratory biomarker analysis


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosis of squamous cell carcinoma of the head and neck, including 1 of the following sites: Hypopharynx Larynx Oral cavity Oropharynx Stage II-IV disease Must have received treatment on clinical trial RTOG-9501 Formalin-fixed paraffin-embedded tissue samples available Exclusion Criteria: Not specified PRIOR CONCURRENT THERAPY: Not specified

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Genetic: microarray analysis|Assay RNA obtained from archived formalin fixed paraffin embedded tissue samples|
|Other: laboratory biomarker analysis|The gene expression data will be linked to the clinical information in order to generate profile of recurrence and survival as a biomarker.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Identification of gene expression profiles used to predict survival as assessed by DNA microarray analysis |  | at time of surgical resection | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
stage II squamous cell carcinoma of the lip and oral cavity, stage III squamous cell carcinoma of the lip and oral cavity, stage IV squamous cell carcinoma of the lip and oral cavity, stage II squamous cell carcinoma of the oropharynx, stage III squamous cell carcinoma of the oropharynx, stage IV squamous cell carcinoma of the oropharynx, stage II squamous cell carcinoma of the hypopharynx, stage III squamous cell carcinoma of the hypopharynx, stage IV squamous cell carcinoma of the hypopharynx, stage II squamous cell carcinoma of the larynx, stage III squamous cell carcinoma of the larynx, stage IV squamous cell carcinoma of the larynx