Population Research of Sublingual Microcirculation Data of Patients With Systemic Diseases

Study Overview
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Brief Summary
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This is an observational clinical study, patients with systemic diseases will be enrolled according to the inclusion and exclusion criteria. Patients will received the examination of sublingual microcirculation by using incident dark field video microscope (Cytocam，Braedius Battery Powered Transilluminator). The microcirculation data includes total small vessel density, perfused small vessel density, microvascular flow index, and heterogeneity index. The patients will be divided into right groups according to their systemic diseases as follows: group 1 hypertension (60 patients), group 2 diabetes mellitus (60), group 3 hypertension and diabetes mellitus (60), group 4 end stage renal disease with hemodialysis (60), group 5 kidney transplant recipients (60), group 6 coronary artery disease (60), and group 7 peripheral arterial occlusive disease (60).

Official Title
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Population Research of Sublingual Microcirculation Data of Patients With Systemic Diseases

Conditions
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Hypertension, Diabetes Mellitus

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients aged from 20 to 79 years old BMI ranged from 18.5 to 27 kg/m2 Presence of one of the condition Diagnosed hypertension > 6 months, without other systemic diseases Diagnosed diabetes mellitus > 6 months, without other systemic diseases Diagnosed with both hypertension and diabetes mellitus > 6 months, without other systemic diseases Diagnosed with end stage renal disease > 6 months Received renal replacement therapy > 6 months Diagnosed with coronary artery disease > 6 months Diagnosed with peripheral arterial occlusive diseases > 6 months Exclusion Criteria: Diagnosed with sepsis, major trauma, or admission to ICU within one month Body temperature higher than 37.5 ℃ or lower than 35.5 ℃ Any on of the following condition Asthma Chronic obstructive pulmonary disease Endocrine diseases Hematological disorders Uncured cancer Chronic uncured infection Other major disease with limited daily activity Non-native speakers

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 89 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Hypertension<br> | |
| Diabetes mellitus<br> | |
| Hypertension and diabetes mellitus<br> | |
| End stage kidney disease<br> | |
| Kidney transplant recipient<br> | |
| Coronary artery disease<br> | |
| Peripheral arterial occlusive disease<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Perfused small vessel density of sublingual small vessels measured by Cytocam |  | Once at enrollment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Total small vessel density of sublingual small vessels measured by Cytocam |  | Once at enrollment |