Time Lapse Assisted Embryo Selection Versus Non Invasive PGT-A Assisted Embryo Selection

Study Overview
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Brief Summary
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This is a prospective randomised study of the evaluation of the clinical IVF results after time lapse assisted embryo selection versus Non-invasive PGT-A assisted embryo selection in subfertile women.

Detailed Description
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A randomized prospective study focusing on subfertile women undergoing IVF treatment followed by embryo transfer on the blastocyst stage. Women assigned to group A proceed to embryo transfer, after time lapse assisted embryo selection, while women of group B after non-invasive PGT-A assisted embryo selection. IVF outcomes, regarding the success rate of the trasnfer and the time required to achieve conception is studied in both groups.

Official Title
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IVF Outcomes Based on Time Lapse Assisted Embryo Selection Versus Non Invasive PGT-A Assisted Embryo Selection

Conditions
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Infertility, Aneuploidy, Chromosome Abnormality

Intervention / Treatment
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* Other: embryo selection


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Women who followed IVF treatment 39 years old or younger Single embryo transfer blastocyst stage cultured embryos Exclusion Criteria: women over the age of 39 years not blastocyst transfer (transfers performed at earlier embryo stage) double embryotransfer women who had invasive PGT-a test women whose embryos were not time-lapse monitored

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 39 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| TIME LAPSE<br>Women who proceed to embryo transfer after time lapse assisted embryo selection. | Other: embryo selection<br>* The basis of embryo seletion for transfer: morphological or genetic after non-invasive PGT-A<br>|
| NI-PGT-A<br>Women who proceed to embryo transfer after non-invasive PGT-A assisted embryo selection. | Other: embryo selection<br>* The basis of embryo seletion for transfer: morphological or genetic after non-invasive PGT-A<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Embryotransfers to conceive | The number of the embryotransfers required for women to conceive | Up to the embryotransfer of the last enrolled patient (Dec 2023) | 
| Time interval to conceive | Time interval required for women to conceive (in months): from OPU day to positive hCG test | Up to the pregnancy test after the last embryo transfer of an enrolled patient (Jan 2024) | 
| Cumulative Live Birth Rate | Cumulative Live Birth Rate achieved after one OPU treatment | Up to 38 weeks after the embryo transfer | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Abortion rate | The spontaneous miscarriage of women in both groups | Up to 2nd trimester miscarriages | 
| DaC rate | The rate of the dilation and curretage rate in both groups | Up to 24 weeks of pregnancy according to Greek Law | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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IVF, PGT-A, NON- INVASIVE PGT-A, TIME LAPSE, EMBRYO SELECTION