Heart Failure and Regional Specific Exercise Training Stimulus

Study Overview
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Brief Summary
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The aim of this study is to determine whether heart failure patients can tolerate a four-weeks of a new exercise training regimen that targets peripheral tissues (Regional Specific Training Stimulus-RSTS) and has been show to produce significant benefits in aerobic capacity and strength in healthy subjects aged 70+years who were at risk for losing functional independence.

Official Title
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Heart Failure and Regional Specific Exercise Training Stimulus

Conditions
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Heart Failure, Sedentary

Intervention / Treatment
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* Other: Regional Specific Training (RSTS)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Men and women between the ages of 55 and 90 Diagnosed with heart failure (NYHA class II-III) Receiving optimal medical therapy Sedentary (≤ 30 min/wk structured physical activity) Peak VO2 between 10 and 30 mL/kg/min. Exclusion Criteria: Oxygen dependent Recent medications changes (within 3 months) Fixed-rate pacemakers Uncontrolled hypertension Type I diabetes Organ transplant Bariatric surgery Renal failure (stage 4 or 5)

Ages Eligible for Study
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Minimum Age: 55 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Regional Specific Training (RSTS)<br>The RSTS protocol was designed to focus on specific peripheral muscle groups without imposing a significant cardiorespiratory strain. Each exercise involved contractions with moderate load but with an extended duration of up to six minutes. Eight specific exercises were performed to target all major muscle groups and enable the routine to be completed within 60 minutes including warm-up, rest periods and stretching between exercises, and cool down exercises | Other: Regional Specific Training (RSTS)<br>* The RSTS protocol was designed to focus on specific peripheral muscle groups without imposing a significant cardiorespiratory strain. Each exercise involved contractions with moderate load but with an extended duration of up to six minutes. Eight specific exercises were performed to target all major muscle groups and enable the routine to be completed within 60 minutes including warm-up, rest periods and stretching between exercises, and cool down exercises.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Subject Adherence & Compliance | The number of training sessions attended and successfully completed divided by the total number of planned sessions | 4 Weeks | 
| One Repetition Maximum (1RM) | Skeletal muscle strength assessed using a one repetition maximum (1RM) measurement obtained for the seated row, chest press, leg press and handgrip. | 4 Weeks | 
| Senior Fitness Test | The Senior Fitness Test is a previously validated battery of 6 physical tasks of daily living used to assess strength, flexibility and endurance in order to detect and predict future limitations in functional capacity. The test is designed to evaluate physical fitness domains including upper-body strength (Arm Curl), lower-body strength (Chair Sit-Stand), upper and lower body flexibility (Back Scratch and Chair Sit and Reach), balance and coordination (8 foot Up and Go), and endurance (Six Minute Walk). | 4 Weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Functional Capacity, Exercise Independence, Peripheral, Strength