Investigation of Vascular Pathology in Eye Diseases Using Using Optical Coherence Tomography Angiography (OCT-A)

Study Overview
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Brief Summary
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Comparison of OCTA to conventional imaging modalities for the diagnosis of eye diseases

Detailed Description
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Optical coherence tomography angiography (OCTA) is a new non-invasive imaging technique that employs motion contrast imaging to high-resolution volumetric blood flow information. OCTA compares the decorrelation signal between sequential OCT b-scans taken at precisely the same cross-section in order to construct a map of blood flow. At present, level 1 evidence of the technology's clinical applications doesn't exist. The investigators plan to compare OCTA as an imaging modality to conventional imaging modalities used in clinical routine.

Official Title
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Investigation of Vascular Pathology in Eye Diseases Using Using Optical Coherence Tomography Angiography (OCT-A)

Conditions
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Retinal Disease

Intervention / Treatment
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* Device: optical coherence tomography angiography


Participation Criteria
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Eligibility Criteria
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Inclusion criteria: Patients from the Department of Ophthalmology, University Hospital Bern requiring conventional imaging for eye disease and willing to sign informed consent Patients of 18 years or older Exclusion criteria: Patients not willing or able to sign informed consent Patients younger than 18 years Patients with epilepsy Patients having had photodynamic therapy within the last 48 hours prior to imaging with OCTA

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Diabetic retinopathy<br>Patients with various degrees of diabetic retinopathy | Device: optical coherence tomography angiography<br>* Imaging with optical coherence tomography angiography<br>|
| Retinal detachment<br>Patients with a history of retinal detachment | Device: optical coherence tomography angiography<br>* Imaging with optical coherence tomography angiography<br>|
| Retinal vein occlusion<br>Patients with a history of retinal vein occlusion | Device: optical coherence tomography angiography<br>* Imaging with optical coherence tomography angiography<br>|
| Arterial hypertension<br>Patients with a history of arterial hypertension | Device: optical coherence tomography angiography<br>* Imaging with optical coherence tomography angiography<br>|
| Carotid artery occlusion<br>Patients with a history of carotid artery occlusion | Device: optical coherence tomography angiography<br>* Imaging with optical coherence tomography angiography<br>|
| Age related macular degeneration<br>Patients with a history of Age related macular degeneration | Device: optical coherence tomography angiography<br>* Imaging with optical coherence tomography angiography<br>|
| Macroaneurysms<br>Patients with a history of retinal macroaneurysms | Device: optical coherence tomography angiography<br>* Imaging with optical coherence tomography angiography<br>|
| Central serous chorioretinopathy<br>Patients with a history of central serous chorioretinopathy | Device: optical coherence tomography angiography<br>* Imaging with optical coherence tomography angiography<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluation of the sensitivity and specificity of OCTA | The primary objective of this observational study is to evaluate the sensitivity and specificity to diagnose vascular abnormalities with OCTA compared to conventional imaging methods. The main parameter that will be assessed is area of nonperfusion of the retina. The incidence (binary) of nonperfusion areas will be assessed in OCTA and compared to conventional imaging methods such as fluorescein angiography. | 2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluation of the intra-and inter-reader reproducibility of the diagnosis of vascular abnormalities using OCTA | The primary objective of this observational study is to evaluate the sensitivity and specificity to diagnose vascular abnormalities with OCTA compared to conventional imaging methods. The main parameter that will be assessed is area of nonperfusion of the retina. The incidence (binary) of nonperfusion areas will be assessed in OCTA and compared to conventional imaging methods such as fluorescein angiography. | 2 years | 
| OCTA and Fundus color photographs | Evaluation whether pathological changes seen in OCT or color fundus photography correlate with changes seen in OCTA | 2 years | 
| Subgroup analysis | Subgroup analysis will be performed with patients suffering from diabetic retinopathy, artery occlusion, carotid stenosis, retinal detachment, vein occlusion, age related macular degeneration, retinal changes from arterial hypertension, retinal macroaneurysms and uveitis. | 2 years |