A Prospective Study on theManagement of Hypertension in Young and Middle-aged Subjects in Enterprises Setting

Study Overview
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Brief Summary
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In recent years, with the investment from government in the health management of the elderly, community management of hypertension in the elderly has made great progress in management rate and standardized management, but the management of young and middle-aged patients with hypertension is still blank. Workplace pressure measurement may be more suitable for most of the young and middle-aged patients to find high blood pressure and monitor blood pressure changes in time. However, there is not much research on workplace pressure measurement. Whether blood pressure measurement in the workplace can reduce the white coat effect, and how it relates to home blood pressure and ambulatory blood pressure is still unclear.

Official Title
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A Prospective Study on theManagement of Hypertension in Young and Middle-aged Subjects in Enterprises Setting

Conditions
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Hypertension, Blood Pressure

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Male and female sex, aged 18-65 years Three different daytime workplace blood pressure measurements meet the limits: systolic blood pressure ≥ 120 mmHg, or diastolic blood pressure ≥80 mmHg Hypertensive patients who are taking antihypertensive drugs Willing to provide information about disease history and lifestyle Willing to receive follow-up for up to 2-3 years Sign the informed consent Exclusion Criteria: Having the onset of cardiovascular and cerebrovascular diseases such as stroke, myocardial infarction or heart failure within 6 months Having a history of atrial fibrillation or frequent arrhythmia Complicating other diseases that are not suitable for the trial, such as thyroid disease with active medication, acute infectious diseases, chronic mental illness, and tumors The subject is participating in other clinical studies.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diagnostic classification in hypertension | Differences in diagnostic classification between workplace blood pressure and daytime ambulatory blood pressure in the classification of hypertension (masked hypertension or white coat hypertension) | 2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in different blood pressure measurement | Differences in workplace blood pressure, daytime ambulatory blood pressure, home blood pressure and 24-hour ambulatory blood pressure | 2 years | 
| The distribution of heart rate in young and middle-aged subjects | The distribution of heart rate in young and middle-aged subjects who were diagnosed with hypertension | 2 years | 
| Progression of target organ damage | Differences in the progression of target organ damage between controlled or uncontrolled subjects or between subjects with fast and slow heart rate | 2 years | 
| The development of with-coat hypertension | The development of white-coat hypertension as persistent hypertension and other types of hypertension or normal blood pressure and changes in target organ damage | 2 years | 
| The proportion of masked hypertension in patients with normal high blood pressure | The proportion of masked hypertension in patients with normal high blood pressure and the change in outcome after treatment intervention and changes in target organ damage | 2 years |