Assessment of Myocardial Tissue Damage in Aortic Stenosis

Study Overview
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Brief Summary
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Aortic stenosis (AS) is the most common valve disease in the United States and most common indication for valve replacement surgery. Anatomical and hemodynamic severity of AS is insufficient for elucidating patients' prognosis. Therefore, the decision about the optimal timing of surgical intervention remains critical. However, the changes in structure and electrical activity of the cardiac muscle can be assessed by noninvasive imaging and electrocardiography (ECG). Degenerative myocardial changes characterized by fibrosis or collagen deposits are frequently observed in AS patients and have a negative impact on patient outcomes. In this project, our objective is to determine whether echocardiographic image analysis of integrated backscatter (IB), which can express changes in myocardial tissue composition (amount of fibrosis) based on its ultrasound reflectivity, global left ventricular (LV) load as measured by Zva, and ECG analysis of the duration of the QRS interval have a role in risk stratification for AS patients and to apply those methods to identify which patients would benefit from surgical intervention. The investigators hypothesize that 1) the severity of myocardial damage can discriminate the prognosis in patients with AS, and 2) IB, Zva, and QRS interval can be diagnostic measures of the severity of myocardial damage. The investigators will measure the severity of myocardial fibrosis using MRI (reference) in 50 patients and will test the diagnostic significance of IB (testing method). Zva, QRS duration, and conventional echocardiographic measures will also be tested for diagnosing severity of myocardial fibrosis.

Official Title
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Assessment of Myocardial Tissue Damage in Aortic Stenosis for Risk Stratification

Conditions
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Aortic Stenosis

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Moderate or severe aortic stenosis determined by echocardiography Adults > 65 years old Exclusion Criteria: Ejection fraction < 50% Valvular diseases of more than or equal to moderate degree other than aortic stenosis Prior myocardial infarction or coronary artery disease needs revascularization Atrial fibrillation (chronic) Pacemaker/defibrillator implanted Previous valve replacement performed Cardiomyopathy(HCM, infiltrative cardiomyopathy, constriction) Renal dysfunction (estimated GFR < 30ml/min/1.73m² or end stage renal failure) Patients with contraindication for MRI Patients with poor echocardiographic images

Ages Eligible for Study
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Minimum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Moderate aortic stenosis.<br> | |
| Severe aortic stenosis.<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Presence of myocardial fibrotic change determined by MRI. |  | 1 hour | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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aortic stenosis, myocardial tissue, echocardiography, MRI