Prevalence of Musculoskeletal Symptoms in the Cambridge NIHR BioResource

Study Overview
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Brief Summary
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Musculoskeletal diseases, such as osteoarthritis, represent a large proportion of the global burden of disease with hip and knee osteoarthritis alone being the 11th greatest cause of disease burden. The purpose of this study is to determine the level of musculoskeletal symptoms in members of the Cambridge National Institute for Health Research (NIHR) BioResource and see if this is associated with their possession of genetic markers that have been identified as being associated with osteoarthritis. This will allow us to determine the real level of musculoskeletal symptoms in this large cohort of volunteers and provide basic information that could be used to facilitate further musculoskeletal research in the NIHR BioResource population.

Detailed Description
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All active members of the Cambridge NIHR BioResource will be approached. They will be sent an email outlining the purpose of the study and asking that if they would like to take part to please complete the online questionnaire which will be linked to in the email. For those individuals who agree to participate and complete the questionnaire, the Cambridge NIHR BioResource will provide the genetic marker information it already holds for specific markers that are known to be associated with osteoarthritis.

Official Title
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Prevalence of Musculoskeletal Symptoms in the Cambridge NIHR BioResource

Conditions
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Musculoskeletal Diseases, Musculoskeletal Injury

Intervention / Treatment
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* Other: Questionnaire including MSK-HQ (Musculoskeletal Health Questionnaire)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Member of the NIHR BioResource Willing to consent to participate Exclusion Criteria: Previous self-report of osteoarthritis on joining BioResource

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Member of BioResource<br>Any BioResource member who consents to take part in the study and completes the study questionnaire. | Other: Questionnaire including MSK-HQ (Musculoskeletal Health Questionnaire)<br>* A questionnaire regarding musculoskeletal past medical history and current symptoms.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| MSK Symptom Levels | Musculoskeletal Symptoms in respondents | 3 months | 
| Osteoarthritis genetic marker | Possession (or not) of specific genetic markers for osteoarthritis (obtained from information already held by the NIHR BioResource) | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| MSK Cohort | Identification of those with particular musculoskeletal injuries and conditions for future studies | 6 months |