Quantitative Evaluation of Muscle Stiffness in Neurological Patients With Muscle Overactivity

Study Overview
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Brief Summary
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Objective: to investigate reliability, validity and responsiveness of shearwave elastography (SWE) to assess muscle stiffness of overactive upper or lower limb muscles in different angle joint positions in patients with neurological condition to investigate the relationship between muscle stiffness measured by SWE and by MyotonPro to investigate the correlation between muscle stiffness measured by SWE and clinical outcomes Methods: each patient will be assessed three times: two times at an interval of 15 minutes on the same day and one time at an interval of one week at the same time of the day. The following measurements will be made at each evaluation: SWE, MyotonPro, clinical evaluation. SWE and MytotonPro will be taken at different angle joint position. Outcomes: muscle stiffness measured by SWE and MyotonPro at different angle joint positions, and clinical evaluation (passive range of motion, modified ashworth scale, tardieu scale, fuglmeyer) Hypothesis: SWE is a valid, reliable, and resposive method to assess muscle stiffness in neurological population with muscle overactivity. The results of SWE will be correlated with the results of MyotonPro and with clinical outcomes.

Official Title
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Reliability, Validity, and Responsiveness of Shearwave Elastography to Assess Muscle Stiffness in Neurological Population With Muscle Overacivity

Conditions
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Muscle Spasticity

Intervention / Treatment
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* Device: shearwave elastography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age > 18 years hemiparesia/-plegia following neurological condition (TBI, stroke,...) > 3 months after injury muscle overactivity in lower limb Exclusion Criteria: other neurological or orthopaedic conditions involving the affected limb aphasia or major cognitive impairment limiting functional assessment botulinum toxin injection in the last 3 months previous treatment of muscle overactivity with surgical procedures.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 99 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: shearwave elastography|shearwave elastography on upper or lower limb|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| reliability, validity and responsiveness shearwave elastography (SWE) to assess muscle elasticity | expressed in m/s. A smaller shearwave velocity indicates a better outcome. | Day 1 | 
| reliability, validity and responsiveness shearwave elastography (SWE) to assess muscle elasticity | expressed in m/s. A smaller shearwave velocity indicates a better outcome | Day 1 + 15 minutes | 
| reliability, validity and responsiveness shearwave elastography (SWE) to assess muscle elasticity | expressed in m/s. A smaller shearwave velocity indicates a better outcome | Day 1 + 7-14 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| muscle stiffness assessment with MyotonPro | a smaller muscle stiffness indicates a better outcome | two times day 1 at 15minutes interval + 7-14 days later at same time of the day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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spasticity, sonoelastography