Removal of Endotracheal Tube Secretions Comprehensively Until Extubation

Study Overview
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Brief Summary
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The purpose of this study is to measure secretion accumulation within endotracheal tubes of mechanically ventilated patients and test the efficacy, safety and clinical impact of removing the secretions using novel airway management catheters (Complete Airway Management Catheters: CAM Rescue Cath and CAM Endotrach Cath).

Detailed Description
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Thirty mechanically ventilated adult patients will be managed with standard suction catheters. Just prior to extubation, their physiological parameters (including work of breathing) will be recorded and acoustic reflectometry used to measure the degree of secretion accumulation within the endotracheal tube. The endotracheal tubes will then be cleaned using the CAM Catheters (Rescue Cath followed by Endotrach Cath) and the physiological parameters and endotracheal tube reflectometry measurements repeated for comparative analysis.

Official Title
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Evaluation of the Safety and Efficacy of CAM (Complete Airway Management) Catheters: Phase II Study

Conditions
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Mechanical Ventilation, Pneumonia

Intervention / Treatment
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* Device: CAM (Complete Airway Management) Catheters


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients receiving medical care in adult intensive care unit setting Patients who have been intubated and mechanically ventilated for at least 12 hours Patients intubated with an endotracheal tube with an internal diameter of 7.0 mm or greater Exclusion Criteria: Patients receiving medical care in a setting not compatible with an adult intensive care unit Patients who have been intubated and mechanically ventilated for less than 12 hours Patients intubated with an endotracheal tube with an internal diameter of 6.5 mm or less Patients intubated with dual lumen or steel-reinforced endotracheal tubes
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: CAM (Complete Airway Management) Catheters|Prior to extubation, endotracheal tube lumen secretions are mechanically removed using CAM Rescue Cath followed by CAM Endotrach Cath.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| work of breathing |  | pre-extubation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| endotracheal tube patency |  | pre-extubation | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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endotracheal tube obstruction, occlusion, mechanical ventilation, complication, work of breathing, airway resistance, secretions, pneumonia, ventilator associated, biofilms, endotracheal tube