Neuroaxial Prophylaxis for CABG

Study Overview
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Brief Summary
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Investigators plan to study the effect of thoracic epidural analgesia on postoperative parameters (complication rate, duration of hospitalization, mortality, etc.) of coronary artery bypass grafting.

Detailed Description
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Investigators plan to conduct a comparative analysis of early postoperative complications of coronary artery bypass grafting with and without cardiopulmonary bypass in patients with independent risk factors for the development of postoperative complications (advanced age, diabetes mellitus, chronic kidney disease, obesity, chronic obstructive pulmonary disease) with various types of anesthesiology benefits (general anesthesia and thoracic epidural analgesia versus general anesthesia and opioids). Investigators predict a decrease in the risk of developing cardiac, respiratory, infectious and renal complications, a reduction in the duration of intensive care, inpatient treatment and mortality.

Official Title
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Consequences of Using Thoracic Epidural Analgesia for Coronary Artery Bypass Grafting

Conditions
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Coronary Artery Occlusion

Intervention / Treatment
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* Procedure: CABG
* Drug: thoracic epidural analgesia
* Drug: analgesia of opioids


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: coronary artery bypass grafting Exclusion Criteria: Absolute contraindications for the use of thoracic epidural analgesia

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Thoracic epidural analgesia<br>CABG and thoracic epidural analgesia will be used for perioperative analgesia postoperative period | Procedure: CABG<br>* coronary artery bypass grafting with and without cardiopulmonary bypass<br>Drug: thoracic epidural analgesia<br>* thoracic epidural analgesia at the level of 1-10 thoracic vertebrae (ropivacainum 0,2-0,5% 5-10 ml/h)<br>|
| Active Comparator: Opioids<br>CABG and opioids will be used for perioperative analgesia | Procedure: CABG<br>* coronary artery bypass grafting with and without cardiopulmonary bypass<br>Drug: analgesia of opioids<br>* Opioids will be used for perioperative analgesia<br>|
| Active Comparator: CABG<br>coronary artery bypass grafting with and without cardiopulmonary bypass | Procedure: CABG<br>* coronary artery bypass grafting with and without cardiopulmonary bypass<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| hospital mortality |  | 1 year | 
| Hospitalization duration |  | 1 year | 
| Duration of treatment in the intensive care unit |  | up to 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Complications |  | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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coronary artery bypass grafting, prevention of complication, neuroaxial prophylaxis, thoracic epidural analgesia