Study of Retinal Function Using Electroretinogram in Regular Alcohol Users

Study Overview
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Brief Summary
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Alcohol is a major public health problem and its neurotoxic effects are, among other things, responsible for altering the functioning of cerebral neurotransmission pathways. The retina is an anatomical and developmental extension of the central nervous system. It is composed of several layers of retinal neurons that share similar anatomical and functional properties with brain neurons. Retinal neurons are notably equipped with a complex system of neurotransmission constituted by the main neurotransmitters that are involved in the central effects of alcohol: glutamate, dopamine, serotonin ... The retina is used here as a site of indirect investigation for abnormal central neurotransmission pathways following regular alcohol use. It is recognized to date as a good site for investigating central abnormalities in neuropsychiatric and addictive disorders. The objective of this project is to study the retinal function using electroretinogram (ERG) in regular alcohol users to isolate potential markers of cerebral neurotransmission abnormalities.

Official Title
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Study of Retinal Function Using Electroretinogram in Regular Alcohol Users

Conditions
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Alcohol Use Disorder

Intervention / Treatment
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* Other: electroretinogram (flash, pattern and multifocal)


Participation Criteria
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Eligibility Criteria
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For alcohol consumer with alcohol use disorder : Inclusion Criteria: aged between 18 and 35 years alcohol use disorder according to the DSM 5 affiliation to a social security scheme Exclusion Criteria: psychoactive substance consumption (other than alcohol) psychiatric disease in progress according to the DSM 5 neurologic disease in progress mental impairment making it difficult or impossible to participate to the study major under guardianship or curatorship or under safeguarding of justice pregnant women or feeding people in emergency situation participation to another interventional study retinal disease in progress chronic glaucoma ophtalmic disease affecting the visual acuity ocular infection in progress urinary positive drug check the day of the inclusion postive Breathalyser the day of the inclusion

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: mono centric study, in parallel groups, controlled, non-randomized and open
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: alcohol consumption with alcohol use disorder (AUD)<br>subjects with regular alcohol consumption with AUD according to the DSM 5 without any other substance use disorder (except alcohol) without psychiatric, neurologic or ophthalmologic disease in progress with a negative drug check and Breathalyzer the day of the inclusion - only one visit is planned for this study : an electroretinogram will be realized | Other: electroretinogram (flash, pattern and multifocal)<br>* we measured the waves a, b, oscillatory potentials, back ground noise and i for the flash ERG, the waves P50 and N95 for the pattern ERG and the P1, N1 and N2 for the multifocal ERG<br>|
| Other: alcohol consumption without alcohol use disorder<br>subjects with regular alcohol consumption without AUD according to the DSM 5 without any other substance use disorder without psychiatric, neurologic or ophthalmologic disease in progress with a negative drug check and Breathalyzer the day of the inclusion - only one visit is planned for this study : an electroretinogram will be realized | Other: electroretinogram (flash, pattern and multifocal)<br>* we measured the waves a, b, oscillatory potentials, back ground noise and i for the flash ERG, the waves P50 and N95 for the pattern ERG and the P1, N1 and N2 for the multifocal ERG<br>|
| Other: no alcohol consumption<br>subjects without alcohol consumption without any other substance use disorder without psychiatric, neurologic or ophthalmologic disease in progress with a negative drug check and Breathalyzer the day of the inclusion - only one visit is planned for this study : an electroretinogram will be realized | Other: electroretinogram (flash, pattern and multifocal)<br>* we measured the waves a, b, oscillatory potentials, back ground noise and i for the flash ERG, the waves P50 and N95 for the pattern ERG and the P1, N1 and N2 for the multifocal ERG<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| modification of amplitude | measured with flash electroretinogram and pattern electroretinogram / amplitude in microvolt | Day 0 (=day of inclusion = the only visit of the study) | 
| modification of implicite time parameters | measured with flash electroretinogram and pattern electroretinogram - implicite time in millisecond | Day 0 (=day of inclusion = the only visit of the study) | 
| modification of amplitude of the oscillatory potential | waves P1, P2, P3, P4 measured with flash electroretinogram - amplitude in microvolt | Day 0 (=day of inclusion = the only visit of the study) | 
| modification of implicit time of the oscillatory potential | waves P1, P2, P3, P4 measured with flash electroretinogram - implicite time in millisecond | Day 0 (=day of inclusion = the only visit of the study) | 
| modification of amplitude of the background noise | measured with the flash electroretinogram, flicker 3.0 sequence - amplitude in microvolt | Day 0 (=day of inclusion = the only visit of the study) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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retina AND electroretinogram