The Efficacy of Adductor-Canal-Blockade on Pain and Morphine Consumption After Revision Knee Arthroplasty

Study Overview
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Brief Summary
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The purpose of this study is to determine whether Adductor-Canal-Blockade is effective at reducing pain and morphine consumption after revision knee arthroplasty.

Official Title
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The Efficacy of Adductor-Canal-Blockade on Pain and Morphine Consumption After Revision Knee Arthroplasty

Conditions
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Postoperative Pain, Knee Arthroplasty

Intervention / Treatment
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* Procedure: Adductor-Canal-Blockade with Ropivacaine
* Procedure: Adductor-Canal-blockade with saline


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Revision Knee Arthroplasty in general anaesthesia American society of anesthesiologists (ASA) 1-3 BMI 18-40 Written informed consent Exclusion Criteria: Can not cooperate to the exam Do not speak or understand Danish Drug allergy Alcohol or drug abuse

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Adductor-Canal-Blockade with ropivacaine<br> | Procedure: Adductor-Canal-Blockade with Ropivacaine<br>* US-guided Adductor-Canal-Blockade with ropivacaine 7,5 mg/ml<br>* Other names: US-guided nerve block;|
| Placebo Comparator: Adductor-Canal-blockade with saline<br> | Procedure: Adductor-Canal-blockade with saline<br>* US-guided Adductor-Canal-blockade with saline<br>* Other names: Placebo block;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain during 45 degrees active flexion of the knee | 0-100 mm at a visual analogue scale (VAS), at 4 hours postoperative. | 4 hours postoperative | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain during 45 degrees active flexion of the knee | 0-100 mm at a visual analogue scale (VAS), registered at the intervals 1, 2, 4, 6 and 8 hours postoperative, calculated as the area under the curve (AUC) for the interval 1-8 hours postoperative. | 1-8 hours postoperative | 
| Pain during 45 degrees active flexion of the knee | 0-100 mm at a visual analogue scale (VAS), at 24 hours postoperative. | 24 hours postoperative | 
| Pain during rest | 0-100 mm at a visual analogue scale (VAS), registered at the intervals 1, 2, 4, 6 and 8 hours postoperative, calculated as the area under the curve (AUC) for the interval 1-8 hours postoperative. | 1-8 hours postoperative | 
| Pain during rest | 0-100 mm at a visual analogue scale (VAS), at 24 hours postoperative. | 24 hours postoperative | 
| Total morphine consumption | Total morphine consumption at the intervals 0-8, 8-24 and 0-24 hours postoperative. | 0-24 hours postoperative | 
| Postoperative nausea | Nausea scores(0-3)registered at 1,2,4,6 and 8 hours postoperative, calculated as mean value for the interval 1-8 hours postoperative. | 1-8 hours postoperative | 
| Postoperative nausea | Nausea score(0-3)at 24 hours postoperative. | 24 hours postoperative | 
| Postoperative vomiting | Number of vomiting episodes at the intervals 0-8, 8-24 and 0-24 hours postoperative. | 0-24 hours postoperative | 
| Zofran consumption | Total zofran consumption at the intervals 0-8, 8-24 and 0-24 hours postoperative. | 0-24 hours postoperative | 
| Sedation | Sedation score (0-3) registered at 1,2,4,6 and 8 hours postoperative, calculated as the mean value for the interval 1-8 hours postoperative. | 1-8 hours postoperative | 
| Sedation | Sedation score (0-3) at 24 hours postoperative. | 24 hours postoperative | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Adductor-Canal-Blockade, postoperative pain, US-guided nerve block, revision knee arthroplasty