Cognitive Processing Therapy vs. Sertraline for the Treatment of PTSD & SUD in Egyptian Patients

Study Overview
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Brief Summary
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The present research was aimed at comparing the effects of Cognitive Processing Therapy (CPT) with the effects of Sertraline in treating patients who have dual diagnosis PTSD & SUD. The present study examines the extent to which CPT is effective in treating PTSD symptoms for patients with PTSD and SUD.

Detailed Description
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Patients with co-occurrence PTSD & SUD disorders were grouped into 3 groups: first: Cognitive Processing Therapy (CPT) in which participants completed 12 sessions of CPT. Second: were treated by Sertraline. Third: a placebo control group.

Official Title
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Cognitive Processing Therapy Versus Sertraline for the Treatment of Post-traumatic Stress Disorder & Substance Use Disorder Egyptian Patients

Conditions
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Psychologic Manipulation

Intervention / Treatment
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* Behavioral: Cognitive processing therapy
* Drug: Sertraline
* Other: Placebo Control


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients diagnosed with SUD Exclusion Criteria: Patients diagnosed with other psychotic disorders
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Data were obtained by interviewing 587 patients diagnosed with SUD. Patients were interviewed by a clinician and asked to complete: Mini-International Neuropsychiatric Interview (M.I.N.I), and Clinician-Administered PTSD Scale (CAPS). Patients with comorbid SUD and PTSD were asked to complete: The Brief Addiction Monitor (BAM), PTSD Checklist-Civilian (PCL-5), Beck Depression Inventory (BDI-II), and Timeline Follow Back Interview (TLFB). Patients with comorbid SUD and PTSD were randomized to one of the following groups: 1) received CPT. 2) received Sertraline. 3) the Placebo control group.
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Cognitive processing therapy<br>Cognitive Processing Therapy (CPT) in which participants completed 12 sessions of CPT | Behavioral: Cognitive processing therapy<br>* Psychological treatment for patients suffering from PTSD and SUD symptoms.<br>|
| Active Comparator: Sertraline<br>Patients with co-occurrence PTSD & SUD disorders were treated by Sertraline. | Drug: Sertraline<br>* Sertraline for the treatment of post-traumatic stress and SU disorders<br>* Other names: SSRI;|
| Placebo Comparator: Control group<br>Placebo Control group | Other: Placebo Control<br>* Placebo Control<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Questionnaire | A psychological parameter will be measured to check the efficacy of CPT against medication for the treatment for co-current PTSD & SUD. The groups will be examined to show if any significant reductions in PTSD and SUD symptoms was obtained over time. | 3 Months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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CPT, PTSD, SUD