Correlation Between Micro Vascular Complications and Severity of Coronary Artery Disease in Type 2 DM

Study Overview
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Brief Summary
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Diabetes is a major cause of morbidity and mortality worldwide and it contributes substantially to healthcare costs. Type 2 Diabetes mellitus is the most common type of diabetes accounting for approximately (90%) of all cases. Type 2 DM carries a two to six times risk of death from cardiovascular etiologies, such that age adjusted prevalence of white Americans for coronary artery disease (CAD) is double in those with type 2 DM than those without .

Official Title
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Correlation Between Micro Vascular Complications and Severity of Coronary Artery Disease in Type 2 DM

Conditions
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Patients With Type 2 DM Who Underwent Coronary Angiography Due to Coronary Artery Disease and Presence of Microvascular Complications in Same Patients

Intervention / Treatment
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* Diagnostic Test: albumin creatinine ratio -EGFR-fundus examination- coronary angiography.


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 100 Cases were selected with type II (DM) patients who had been admitted for coronary angiography because of suspected (CAD) to the Catheter lab unit of Sohag University Hospital. Exclusion Criteria: Type 1 DM. Smoker. Hypertension. Pregnant women. Patient known non diabetic retinal disease non diabetic. nephropathy or neuropathy. History of familial dyslipidemia.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| patients type 2 DM with coronary artery disease and diabetic retinopathy.<br> | Diagnostic Test: albumin creatinine ratio -EGFR-fundus examination- coronary angiography.<br>* albumin creatinine ratio and EGFR to assess. diabetic nephropathy. fundus examination to assess. diabetic retinopathy. assess of coronary artery disease by coronary angiography. assess diabetic nephropathy by neurologic examination.<br>|
| patients type 2 DM with coronary artery disease and diabetic neuropathy.<br> | Diagnostic Test: albumin creatinine ratio -EGFR-fundus examination- coronary angiography.<br>* albumin creatinine ratio and EGFR to assess. diabetic nephropathy. fundus examination to assess. diabetic retinopathy. assess of coronary artery disease by coronary angiography. assess diabetic nephropathy by neurologic examination.<br>|
| patients type 2 DM with coronary artery disease and diabetic nephropathy<br> | Diagnostic Test: albumin creatinine ratio -EGFR-fundus examination- coronary angiography.<br>* albumin creatinine ratio and EGFR to assess. diabetic nephropathy. fundus examination to assess. diabetic retinopathy. assess of coronary artery disease by coronary angiography. assess diabetic nephropathy by neurologic examination.<br>|
| patient type 2 DM with coronary artery disease and non microvascular complications.<br> | Diagnostic Test: albumin creatinine ratio -EGFR-fundus examination- coronary angiography.<br>* albumin creatinine ratio and EGFR to assess. diabetic nephropathy. fundus examination to assess. diabetic retinopathy. assess of coronary artery disease by coronary angiography. assess diabetic nephropathy by neurologic examination.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| correlation between microvascular complications and severity of coronary disease in type2 DM. | outcome of study to assess correlation between coronary artery disease and microvascular complications in type 2 DM to early predict coronary artery disease in patient type 2 DM with microvascular complications by non invasive methods as stress ECG or CT coronary angio or cardiac MRI and prevent serious complications as myocardial infarction. assess microvascular complication as follow albumin creatinine ratio and EGFR to assess. diabetic nephropathy. fundus examination to assess. diabetic retinopathy. assess of coronary artery disease by coronary angiography. assess diabetic nephropathy by neurologic examination. | 4 months |