Effect of Oral Carbohydrate on Serum S-100β Protein and Development of Postoperative Delirium in Elderly Patients

Study Overview
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Brief Summary
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This study is to evaluate the effects of preoperative carbohydrate intake on perioperative neuroinflammation and development of delirium.

Detailed Description
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Perioperative insulin resistance may primarily contribute to development of postoperative delirium in high risk patients. Preoperative administration of oral carbohydrate reduces insulin resistance. The investigators aimed to investigate the influence of carbohydrate loading on the serum level of S-100β, a surrogate marker of delirium, and the incidence of postoperative delirium in elderly patients.

Official Title
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Effect of Oral Carbohydrate on Serum S-100β Protein and Development of Postoperative Delirium in Elderly Patients

Conditions
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Insulin Resistance, Inflammation, Delirium

Intervention / Treatment
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* Dietary Supplement: Allocated to Carbohydrated group
* Dietary Supplement: Allocated to Placebo group


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients undergoing total hip replacement or total knee replacement surgery Exclusion Criteria: Diabetes Dementia Gastro-esophageal reflux Upper gastrointestinal motility disorder Inflammatory bowel disease Intraperitoneal malignancy history Inability to perform cognitive function test

Ages Eligible for Study
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Minimum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Allocated to Carbohydrated group<br>Patients was administered in hospital Randomization Patient was allocated to Carbohydrated group Patients received 400 mL of oral isotonic glucose (No NPO®, Daesang, Korea) 12 hours before anesthesia and 400 mL 2 hours before. CHL composition was standard: 12.5 g of carbohydrate per 100 mL, 12% monosaccharide, 12% disaccharide, 76% polysaccharide, 250 mOsm/kg and 50 kcal. | Dietary Supplement: Allocated to Carbohydrated group<br>* Patients received 400 mL of oral isotonic glucose (No NPO®, Daesang, Korea) 12 hours before anesthesia and 400 mL 2 hours before. CHL composition was standard: 12.5 g of carbohydrate per 100 mL, 12% monosaccharide, 12% disaccharide, 76% polysaccharide, 250 mOsm/kg and 50 kcal.<br>* Other names: No NPO;|
| Placebo Comparator: Allocated to Placebo group<br>Patients was administered in hospital Randomization Patient was allocated to Placebo group Patients received 400 mL of water 12 hours before anesthesia and 400 mL 2 hours before anesthesia. | Dietary Supplement: Allocated to Placebo group<br>* Patients received 400 mL of oral flavored water (Placebo) 12 hours before anesthesia and 400 mL 2 hours before<br>* Other names: flavored water;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| serum S-100β level |  | Postoperative 1 hr |