In-vivo Optical Coherence Tomography Imaging in Dermatooncology

Study Overview
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Brief Summary
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In vivo differentiation of benign and malignant skin lesions is a fundamental issue in clinical dermatology. Malignant skin diseases are known to be accompanied by structural alterations. Conventional excisional biopsies and further histopathology are regarded as the reference standard for investigating these pathologies. Biopsies are invasive procedures and additionally may cause side effects. Therefore, research efforts are focused on the development of diagnostic techniques capable of providing in vivo information on the skin's structure. Optical coherence tomography (OCT) is a technical application, which allows the identification of microscopic patterns indicative for benign and malignant skin lesions. OCT is a promising noninvasive imaging technique for the micromorphology of the skin. So far, it's clinical application, as an additional diagnostic tool for malignant skin lesions has been studied in a limited extend. To evaluate the clinical usefulness of OCT, we conducted a prospective pilot study at the Department of Dermatology, Medical University of Vienna. The study is in cooperation with the Center of Biomedical Engineering and Physics at the Medical University of Vienna. A total of 70 malignant skin lesions was evaluated during this prospective pilot study. Diagnoses based on OCT imaging as an additional diagnostic tool, were compared to those based on the clinical standard pathway at the Department of Dermatology, Medical University of Vienna. For the purpose of this study, the histopathological diagnosis was used as the reference diagnostic standard. The major aims of this study is the investigation of the ability of ultrahigh resolution OCT to identify fine morphological characteristics associated with basal cell carcinoma, actinic keratosis, superficial squamous cell carcinoma, seborrheic keratosis, melanocytic nevi and melanoma. To correlate the morphologic features identified with ultrahigh resolution OCT with routine histopathology To investigate the clinical feasibility of ultrahigh resolution and spectroscopic OCT technology To assess the effectiveness of ultrahigh resolution and spectroscopic OCT imaging to diagnose various melanocytic and non-melanocytic skin tumors To compare the diagnostic capabilities of ultrahigh resolution OCT with standard non-invasive diagnostic procedures such as epiluminescence microscopy

Detailed Description
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Optical coherence tomography (OCT) is a technical application, which allows the identification of microscopic patterns indicative for benign and malignant skin lesions. It is a promising non-invasive imaging technique for the micromorphology of the skin. OCT provides in vivo cross sectional tomographic images of tissue in situ and real-time with micrometer resolution. It works analogously to ultrasound; the reflection of infrared light, instead of acoustical waves, from the skin is measured and the signal strength is imaged as a function of position. Depending on the scattering properties of tissue and some accepted loss in resolution, a penetration depth of up to 2 mm can be achieved. The image data are displayed by assigning color or gray scales to each reflection, according to the measured signal strength. The OCT probe is applied directly after application of ultrasound gel to the skin. Acquisition time for an OCT image is approximately 3 seconds.

Official Title
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Improving Diagnosis of Skin Cancer Patients Via Optical Coherence Tomography and Teledermatology- A Pilot Study

Conditions
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Non-melanocytic Skin Tumors, Melanocytic Skin Tumors

Intervention / Treatment
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* Other: in-vivo skin tumor imaging via optical coherence tomography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: seborrhoeic warts nevi dermatofibroma basal cell carcinoma actinic keratosis squamous cell carcinoma Bowen's disease Merkel cell carcinoma malignant melanoma Exclusion Criteria: employers of the Medical University of Vienna patients during compulsory military service patients with an appointed guardian

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| skin cancer<br>Skin cancer patients with scheduled tumor excision and subsequent histopathological analysis of the tumor. | Other: in-vivo skin tumor imaging via optical coherence tomography<br>* optical coherence tomography imaging of skin lesion; digital dermoscopy imaging of skin lesion<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Optical coherence tomography (OCT) imaging quality of skin tumor formations versus corresponding histopathology. |  | two years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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in-vivo skin imaging, non-invasive non-melanoma skin cancer diagnostics