Effects of the Low-level Laser Therapy (LLLT) on Muscle Strength (MS) of the Patients With Kidneys Failure (KF)

Study Overview
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Brief Summary
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The low-level laser therapy (LLLT) has been used in many inflammatory disorders. More recently the LLLT was associated with an improvement in the muscle strength and endurance. But, these effects were described only in health or athletic individuals. In this randomized and controlled clinical trails, the investigators will study the effects of LLLT on muscle strength of the patients with kidneys failure on long time hemodialysis treatment. Additionally, investigators will explore three different intensities up the muscle strength.

Detailed Description
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This study will be conducing in a large hospital that is reference in kidneys disorders treatments. 16 patients will be randomized for placebo, 4J, 6J, or 8J low-level laser therapy (LLLT). The maximal voluntary contraction (MVC) will be test by handgrip test before and after de LLLT. One-week interval between the LLLT will gave to reduce the influence between the treatments. Moreover the endurance test will be use to evaluate the muscle oxidation impact of the LLLT.

Official Title
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Effects of the Different Intensities of the Low-level Laser Therapy on Handgrip Test on Patients With Kidneys Failure: A Randomized, Controlled Clinical Trail

Conditions
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Chronic Kidney Failure

Intervention / Treatment
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* Device: 0J LLLT
* Device: 4J LLLT
* Device: 6J LLLT
* Device: 8J LLLT


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: chronic kidney failure, long time hemodialysis treatment (>18 months) Exclusion Criteria: any health disturbance that can reduces the handgrip test performance beyond to the produced by the chronic kidney failure.

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Sham Comparator: 0J LLLT<br>The intervention will be made with the machine off. | Device: 0J LLLT<br>* Sham Low-Level Laser Therapy (Sham LLLT): perform with the machine off.<br>* Other names: Sham LLLT;|
| Experimental: 4J LLLT<br>The Laser radiation will be made with 4J by spot. | Device: 4J LLLT<br>* 4J Low-Level Laser Therapy (4J LLLT) irradiation will be perform with 4J.<br>* Other names: 4J;|
| Experimental: 6J LLLT<br>The Laser radiation will be made with 6J by spot. | Device: 6J LLLT<br>* 6J Low-Level Laser Therapy (6J LLLT) irradiation will be perform with 6J.<br>* Other names: 6J;|
| Experimental: 8J LLLT<br>The Laser radiation will be made with 8J by spot. | Device: 8J LLLT<br>* 8J Low-Level Laser Therapy (8J LLLT) irradiation will be perform with 8J.<br>* Other names: 8J;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Muscle Strength (Handgrip Test) |  | once a week throughout 4 weeks |