linjc16/ctgov huggingface dataset:
Improvement of Language Disturbances After Stroke by Intensive Training and Electrical Brain Stimulation

Study Overview
=================
Brief Summary
-----------------
The study aims to identify if intensive language training, consisting mainly of computer-based object naming, together with electrical brain stimulation, will lead to an improvement of language functions in patients that suffer from language disturbances after a stroke.

Official Title
-----------------
Improvement of Aphasia After Stroke by Intensive Training and Transcranial Direct Current Stimulation

Conditions
-----------------
Aphasia, Stroke

Intervention / Treatment
-----------------
* Device: anodal tDCS
* Device: cathodal tDCS
* Device: sham stimulation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: chronic stroke (> 1 year after event) aphasia due to stroke with naming impairment German as first language first-ever stroke Exclusion Criteria: more than 1 stroke progressive stroke history of severe alcohol or drug abuse, psychiatric illnessess like severe depression, poor motivational capacity dementia contraindications for Magnetic Resonance Imaging

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: anodal tDCS<br> | Device: anodal tDCS<br>* anodal transcranial direct current stimulation<br>|
| Active Comparator: 2<br>cathodal tDCS | Device: cathodal tDCS<br>* cathodal transcranial direct current stimulation<br>|
| Placebo Comparator: 3<br>sham stimulation | Device: sham stimulation<br>* sham stimulation<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of words correctly named after training plus tDCS |  | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Communicative-Activity-Log & Stroke-and-Aphasia-Quality-of-Life-Scale |  | 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
stroke, aphasia, rehabilitation, transcranial direct current stimulation, intensive training, chronic aphasia after stroke
Atherosclerosis and Omega-3 Fatty Acids in Alaskan Natives

Study Overview
=================
Brief Summary
-----------------
To determine whether there were differences in the prevalence and extent of atherosclerotic lesions in the coronaries and aortas between Alaskan natives and non-natives, and whether the extent of the lesions was related to omega-3 fatty acids in blood and tissues.

Detailed Description
-----------------
BACKGROUND: Purported low mortality from coronary heart disease in Eskimos from Greenland, Canada, or Alaska has been interpreted by many investigators as synonymous with the absence of or reduced amount of atherosclerotic lesions in the coronary arteries compared to populations with a high rate of coronary heart disease. It was thought that this study would help to clarify the role of omega-3 fatty acids in atherosclerosis but also would help in making a decision whether to recommend to the general public the inclusion of fish oils, which contain large amounts of these fatty acids in the diet, for prevention and/or reduction of atherosclerotic heart disease. DESIGN NARRATIVE: Coronary arteries, aortas, blood, adipose tissue, and liver were collected at autopsy from deceased Alaskan natives, aged 5 years and above, dying of all causes and from a similar number of age- and sex-matched non-native Alaskans. Tested standardized methods of gross evaluation, histomorphometry, and chemistry were used to characterize, measure, and evaluate the prevalence and extent of atherosclerosis in arteries. Chemical methods for determination of blood and tissue lipids and gas liquid chromatographic methods for determination of fatty acids in various lipid fractions in plasma and tissues were used. Risk factors for coronary artery disease were evaluated from tissues taken at autopsy. Hypertension was evaluated by an examination of kidney arterioles. Cigarette smoking was evaluated by measurement of thiocyanate in the blood and the presence or absence of diabetes was evaluated by measuring glycosylation of hemoglobin from red blood cells. Findings were compared with those studied in other populations such as Blacks and whites in New Orleans, and Japanese, Norwegians and nineteen other ethnic groups in the International Atherosclerosis Project. The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System (PRS) record.

Conditions
-----------------
Cardiovascular Diseases, Heart Diseases, Atherosclerosis, Coronary Arteriosclerosis

Participation Criteria
=================
Eligibility Criteria
-----------------
No eligibility criteria

Ages Eligible for Study
-----------------
Maximum Age: 100 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Chest Pain, Illness Perception Compliance and Psychosocial Outcome After Coronary Arteriography

Study Overview
=================
Brief Summary
-----------------
Chest pain, illness perception compliance and psychosocial outcome after coronary arteriography. A comparison between patients which were diagnosed with slow coronary flow and patients who have been diagnosed with coronary artery occlusion. We hope to prove that the more knowledge and awareness the patient has about his disease the better his compliance and rehabilitation.

Conditions
-----------------
Coronary Disease

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adult patients with slow flow or coronary artery occlusion Exclusion Criteria: All other patients

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 88 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| I<br>Coronary Slow Flow Patients | |
| II<br>Coronary Artery Occlusion Patients | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Coronary disease, Psychosocial, Nursing
Phase II Study of Dietary Cholesterol for Smith-Lemli-Opitz Syndrome

Study Overview
=================
Brief Summary
-----------------
OBJECTIVES: I. Examine the intestinal absorption of dietary cholesterol in patients with Smith-Lemli-Opitz syndrome. II. Measure the effect of dietary cholesterol on plasma sterol composition. III. Quantify basal cholesterol synthesis, turnover of cholesterol and 7-dehydrocholesterol, and the effects of dietary cholesterol on these parameters. IV. Identify fecal bile acid excretion quantitatively and qualitatively in these patients. V. Compare the incorporation of deuterated water into plasma cholesterol, 7-dehydrocholesterol, and other intermediates, and assess the effect of dietary cholesterol on this incorporation.

Detailed Description
-----------------
PROTOCOL OUTLINE: Patients are treated with 2 dietary regimens for 1 to 3 weeks: high cholesterol and cholesterol-free. Cholesterol is provided in the form of egg yolk. The absorption and metabolism of cholesterol are evaluated with plasma and fecal studies. Deuterated water is given to patients followed by analysis of deuterium in plasma cholesterol and other intermediates, including 7-dehydrocholesterol.

Official Title
-----------------
The Effects of Dietary Cholesterol in the Smith-Lemli-Opitz Syndrome

Conditions
-----------------
Smith-Lemli-Opitz Syndrome

Intervention / Treatment
-----------------
* Behavioral: diet


Participation Criteria
=================
Eligibility Criteria
-----------------
PROTOCOL ENTRY CRITERIA: Smith-Lemli-Opitz syndrome

Ages Eligible for Study
-----------------
Minimum Age: 0 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment


Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: diet|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Smith-Lemli-Opitz syndrome, genetic diseases and dysmorphic syndromes, rare disease
Urine Biomarkers for Renal Function Monitoring in Preterm Infants

Study Overview
=================
Brief Summary
-----------------
The true renal function of preterm infants is difficult to evaluate. Serum creatinine (Cr) levels in infants are unreliable as a detector of renal function in the first few days of life because they may continue to reflect maternal levels. Although few candidates appear to be a useful biomarker for kidney injury, scant reference data on these biomarker in preterm infants exist, and studies have yielded conflicting results. Therefore, we aimed to determine the reliable urinary biomarkers to detect kidney injuries in preterm infants.

Conditions
-----------------
Premature Infant

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: premature infants born before 37 weeks of gestational age Exclusion Criteria: cardiac or renal anomalies transferred in 2 days after birth from other hospitals

Ages Eligible for Study
-----------------
Minimum Age: 1 Day
Maximum Age: 2 Weeks

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| correlation of urinary NGAL (neutrophil-gelatinase-associated lipocalin) with serum creatinine |  | postnatal 1day | 
| correlation of urinary NGAL (neutrophil-gelatinase-associated lipocalin) with serum creatinine |  | postnatal 3day | 
| correlation of urinary NGAL (neutrophil-gelatinase-associated lipocalin) with serum creatinine |  | postnatal 5day | 
| correlation of urinary NGAL (neutrophil-gelatinase-associated lipocalin) with serum creatinine |  | postnatal 7day |
What we Think About the Do-not-resuscitate Order: Survey Study

Study Overview
=================
Brief Summary
-----------------
The do not resuscitate (DNR) order is a decision taken by the patient or other people about medical care in the end stages of life to withhold CPR in event of respiratory or cardiac arrest and allow natural death to occur. There is currently no related article of law to DNR order in Turkey. It was aimed to evaluate the health workers(HW) and the non health workers'(NHW) knowledge, attitude, and behavior related to the do-not-resuscitate (DNR) order in Turkey.

Detailed Description
-----------------
The do not resuscitate (DNR) order is a decision taken by the patient or other people about medical care in the end stages of life to withhold CPR in event of respiratory or cardiac arrest and allow natural death to occur. There is currently no related article of law to DNR order in Turkey. A questionnaire with 25 questions has been distributed to health workers and non-health workers. It was aimed to evaluate the health workers(HW) and the non health workers'(NHW) knowledge, attitude, and behavior related to the do-not-resuscitate (DNR) order in Turkey.

Official Title
-----------------
What we Think About the Do-not-resuscitate Order: Survey Study

Conditions
-----------------
Knowledge, Attitudes, Practice

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adults ≥18 years of age People who are able to complete the questionnaire Exclusion Criteria: -

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 100 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Health workers' and Non-health workers' knowledge about the DNR order | Rate of DNR order's knowledge | 20-30 minutes. | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
The do-not-resuscitate order, end of life, medical ethics
Bioequivalency Study of Morphine Sulfate Injection, Solution and Tablet Under Fasted Conditions

Study Overview
=================
Brief Summary
-----------------
Determine the pharmacokinetics and optimize study design for subsequent studies with morphine sulfate tablets and solution.

Official Title
-----------------
A Single Dose, Three-Period, Three-Treatment, Six-Sequence, Three-Way Crossover Pharmacokinetic and Comparative Bioavailability Study of Morphine Sulfate Injection, Solution, and Tablet Formulations Under Fasting Conditions.

Conditions
-----------------
Pain

Intervention / Treatment
-----------------
* Drug: morphine sulfate


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: No clinically significant abnormal findings on the physical examination, medical history, or clinical laboratory results during screening. Exclusion Criteria: Positive test for HIV, Hepatitis B, or Hepatitis C. Treatment with known enzyme altering drugs. History of allergic or adverse response to morphine sulfate or any comparable or similar product.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: morphine sulfate|morphine sulfate 30 mg tablet, morphine sulfate 30 mg (10 mg / 5 mL) oral solution, morphine sulfate injection 10 mg (1 mg / mL)|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| bioequivalence determined by statistical comparison Cmax |  | 7 days |
Safety and Efficacy of INGAP-Peptide in Patients With Type 2 Diabetes

Study Overview
=================
Brief Summary
-----------------
Insulin is a chemical that the body needs in order to use or store sugar. It is made by a type of cell called a beta cell which resides in an organ known as the pancreas. Type 2 diabetes is a disease where the beta cells are unable to meet a person's insulin needs. Sugar levels rise in the blood as a result. INGAP-Peptide is being tested to attempt to create new beta cells in the pancreas, and to improve the ability to produce insulin in type 2 diabetic patients.

Official Title
-----------------
A Randomized, Double-blind, Placebo-controlled, Rising-dose, Multicenter Study to Evaluate the Efficacy and Safety of 90 Days of 300 or 600 mg Daily Subcutaneous Injections of INGAP Peptide in Insulin-using Type 2 Diabetes Mellitus Patients

Conditions
-----------------
Diabetes Mellitus, Non-Insulin-Dependent

Intervention / Treatment
-----------------
* Drug: INGAP-Peptide
* Drug: INGAP-Peptide
* Drug: placebo


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria Age 35-70 Using >20 Units of insulin per day HbA1c from 6.5% to 10% No islet antibodies Otherwise healthy

Ages Eligible for Study
-----------------
Minimum Age: 35 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: placebo<br>1.5 mL SC injection, once daily for 90 days | Drug: placebo<br>* 1.5 mL, once daily, self-administered SC injection for 90 days<br>|
| Experimental: 300 mg INGAP Peptide<br>1.5 mL SC injection, once daily for 90 days | Drug: INGAP-Peptide<br>* 1.5 mL, once daily, self-administered SC injection for 90 days<br>|
| Experimental: 600 mg INGAP Peptide<br>1.5 mL SC injection, once daily for 90 days | Drug: INGAP-Peptide<br>* 1.5 mL, once daily, self-administered SC injection for 90 days<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Type 2 diabetes
Treatment Efficacy for Drug Abuse and AIDS Prevention - 1

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to assess the safety and effectiveness of buprenorphine for treatment of concurrent intravenous heroin and cocaine dependence.

Official Title
-----------------
Treatment Efficacy for Drug Abuse and AIDS Prevention

Conditions
-----------------
Cocaine-Related Disorders, Heroin Dependence

Intervention / Treatment
-----------------
* Drug: Buprenorphine


Participation Criteria
=================
Eligibility Criteria
-----------------
Please contact site for information.

Ages Eligible for Study
-----------------
Minimum Age: 26 Years
Maximum Age: 41 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Buprenorphine|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
opioid addiction, cocaine addiction
Comparison Between the Clinical Assessment of the Undescended Testis and Its' Ultrasonographic Size

Study Overview
=================
Brief Summary
-----------------
In addition to the manual preoperative examination, the undescended testicle will be measured ultrasonographically. The compared data will help us to evaluate the routine need for preoperative ultrasonographic evaluation of the undescended testicle.

Official Title
-----------------
Comparison Between the Clinical Assessment of the Undescended Testis and Its' Ultrasonographic Size

Conditions
-----------------
Undescended Testis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Boys operated for unilateral cryptorchism Exclusion Criteria: bilateral cryptorchism recurrent operation s/p inguinal operation

Ages Eligible for Study
-----------------
Minimum Age: 1 Year
Maximum Age: 13 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| study group<br>The surgeon will estimate the size difference between the undescended and the normally located testis. Independently the ultrasonographer will measure the true size of both testes in the study group. | |
| Control group<br>The same measurments will be done by the surgeon and the ultrasonographer on boys without cryptorchism. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The difference between the testicular size estimated by the surgeon and the actual ultrasonographic size | The difference between the testicular size estimated by the surgeon and the actual ultrasonographic size | 3 years |
Therapeutic Touch on Labour Pain, Anxiety and Childbirth Attitude

Study Overview
=================
Brief Summary
-----------------
Introduction: Touching ensures physical, emotional and spiritual relaxation, confidence, peace, calmness and well-being, and increases self-esteem. The aim of this study is to determine the effect of therapeutic touch on labour pain, anxiety and childbirth attitude. Methods: The sample of this randomized controlled experimental research consisted of 80 (intervention group: 40; control group: 40) women. Data were collected using a Personal Information Form, Visual Analogue Scale, State Anxiety Inventory and Childbirth Attitudes Questionnaire.

Official Title
-----------------
The Effect of Therapeutic Touch on Labour Pain, Anxiety and Childbirth Attitude

Conditions
-----------------
First Pregnancy, Vaginal Delivery

Intervention / Treatment
-----------------
* Other: Therapeutic touch


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Having a first pregnancy Not having a high-risk pregnancy Having no health problems with the baby or herself Having a single foetus Being about to have a vaginal delivery Not receiving infertility treatment Not having a chronic physical or psychiatric diagnosis Agreeing to participate in the research Exclusion criterion -Multiparity

Ages Eligible for Study
-----------------
Minimum Age: 19 Years
Maximum Age: 41 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Control Group<br>Group name | Other: Therapeutic touch<br>* Therapeutic touch was applied twice to the women in the intervention group in addition to routine practices. The first application was performed in the active phase of the first stage of labour, and the second was done in the second stage of labour.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Scale | Visual Analogue Scale | 6 months | 
| Inventory | State Anxiety Inventory | 6 months | 
| Questionnaire | Childbirth Attitudes Questionnaire | 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
therapeutic touch, labour pain, anxiety, childbirth attitude