Caffeine and Sodium Citrate Ingestion

Study Overview
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Brief Summary
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A positive ergogenic effect of sodium citrate and caffeine ingestion in a short-term, high-intensity exercise task was shown by several studies. These studies were conducted with healthy, able-bodied subjects. The aim of the study is to investigate whether caffeine or sodium citrate ingestion could enhance performance in spinal cord injured wheelchair athletes. It is a double blind, placebo controlled and randomized study.

Detailed Description
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The athletes have to complete four 1500m tests on a training roller. Before each treatment they get different supplementations. Once they get sodium citrate and a placebo, once caffeine and a placebo, once sodium citrate and caffeine and for the fourth treatment they get twice a placebo. Two hours after starting with the supplementation they have to complete the 1500m as fast as possible. Time to complete 1500m, blood pH, plasma bicarbonate, sodium concentration, heart rate, oxygen consumption, blood lactate concentration and rate of perceived exertion (RPE) were measured.

Official Title
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Effects of Caffeine and Sodium Citrate Ingestion in 1500m Wheelchair Racing Athletes

Conditions
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Dietary Supplements, Heart Rate/Drug Effects, Lactic Acid/Metabolism, Physical Education and Training/Methods, Wheelchairs

Intervention / Treatment
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* Dietary Supplement: Caffeine
* Dietary Supplement: Sodium Citrate
* Dietary Supplement: Mannitol
* Dietary Supplement: Sodium Chloride


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: wheelchair athletes national team category T53 and T54 Exclusion Criteria: medicated pregnant (for women) cardiovascular and respiratory diseases

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Caffeine<br>6mg per kg bodyweight ingested 60min before test | Dietary Supplement: Caffeine<br>* gelatine capsule 6mg/kg bodyweight 60min prior test<br>Dietary Supplement: Sodium Chloride<br>* sodium chloride diluted in 7dl water 0.045g/kg bodyweight 120-90min prior test<br>|
| Placebo Comparator: Placebo<br>Sodium chloride and mannitol as placebo are ingested by the athlete | Dietary Supplement: Mannitol<br>* gelatine capsule filled with mannitol (100mg per capsule) ingested 60min prior test<br>Dietary Supplement: Sodium Chloride<br>* sodium chloride diluted in 7dl water 0.045g/kg bodyweight 120-90min prior test<br>|
| Active Comparator: Sodium Citrate<br>sodium citrate diluted in 7dl water, ingestion 120 to 90min prior test | Dietary Supplement: Sodium Citrate<br>* 0.5g/kg bodyweight diluted in 7dl water ingested 120-90min prior test<br>Dietary Supplement: Mannitol<br>* gelatine capsule filled with mannitol (100mg per capsule) ingested 60min prior test<br>|
| Active Comparator: Caffeine and Sodium Citrate<br>sodium citrate 120-90min prior test capsules:60min prior test | Dietary Supplement: Caffeine<br>* gelatine capsule 6mg/kg bodyweight 60min prior test<br>Dietary Supplement: Sodium Citrate<br>* 0.5g/kg bodyweight diluted in 7dl water ingested 120-90min prior test<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time | Time to complete 1500m | 3 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Heart Rate | Heart Rate measured from 2min before the test until 5min after the 1500m-test. | during study phase of 3 week (4 tests) | 
| Lactate Concentration | 1min before starting the warm up, 15s after the end of the warm up, 15s after completing the test, 2min/4min/6min/8min/10min after the test | during the 3 weeks study phase | 
| blood pH, sodium concentration and plasma bicarbonate | 1min before starting with the ingestion of the fluid, immediately before starting the warm up, just immediately before starting the 1500m test. | during the 3 weeks of study phase | 
| Oxygen Consumption | oxygen consumption (VO2(ml/min/kg), VCO2(ml/min), RER (VCO2/VO2)) starting of the measurement is 2min before the start of the 1500m and ends 2min after having completed the 1500m | during 3 weeks of study phase | 
| rating of gastrointestinal stress | 1min before starting to drink the fluid, 2min before starting with the warm up, 2min before the test and 2min after having completed the 1500m | during the 3 weeks of study phase | 
| Rating of Perceived Exertion (RPE) | 15s after the end of the warm up, 15s after having completed the 1500m | during the 3 weeks of study phase | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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caffeine, sodium citrate, exercise performance, wheelchair athletes, 1500m