Craniopharyngioma With Tumoral Hemorrhage

Study Overview
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Brief Summary
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Clinical data of 185 consecutive patients receiving resective operation with a pathological diagnosis of craniopharyngioma in our hospital between January 2013 and February 2021 were collected. Among these patients, 18 of them were recognized as craniopharyngioma with tumoral hemorrhage during the operation.

Detailed Description
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For each case, age, gender, smoking status, alcohol intake, past history, symptoms, blood pressure, blood cell count, blood biochemical tests, coagulation tests, hormone tests, radiological results, surgical treatment and the outcome at discharge were collected. The first test result after admission and before the operation was taken for the items of blood tests with multiple times in the analysis.

Official Title
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Clinical Features and Risk Factors of Craniopharyngioma With Tumoral Hemorrhage

Conditions
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Craniopharyngioma, Apoplexy

Intervention / Treatment
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* Other: intratumoral hemorrhage


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: receive resective operation with a pathological diagnosis of craniopharyngioma in our hospital enter our hospital between January 2013 and February 2021 Exclusion Criteria: have a non-craniopharyngioma or unverified pathological diagnosis at discharge have received surgical or radiological treatment on the sellar region receive treatment of coagulation modulation, immunosuppressive agents or chemotherapeutic drugs combine with other clinical emergencies including acute myocardial infarction, cerebral stroke, trauma and sepsis at admission have been diagnosed with other tumors, hematological diseases, autoimmune diseases, liver failure or renal failure
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Non-hemorrhage group<br>Patients recognized as craniopharyngioma pathologically without tumoral hemorrhage observed during the operation | |
| Hemorrhage group<br>Patients recognized as craniopharyngioma pathologically with tumoral hemorrhage observed during the operation | Other: intratumoral hemorrhage<br>* Patients who were recognized as craniopharyngioma pathologically with tumoral hemorrhage observed during the operation were enrolled in the hemorrhage group.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| craniopharyngioma with tumoral hemorrhage | Current study is a case-control study whose primary outcome is tumoral hemorrhage observed during the operation, which devided the craniopharyngioma patients into hemorrhage group and non-hemorrhage group. | during the operation | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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endocrine, risk factor, tumoral hemorrhage, craniopharyngioma