Consumption of Eggs Rich in Lutein and Omega-3 Fatty Acids on the Macular Pigment

Study Overview
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Brief Summary
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This study is to determine the impact of the consumption of eggs rich in lutein/zeaxanthin from lucerne protein concentrate and DHA from microalgae on the plasma levels of these compounds but also on the macular pigment optical density, whose elevation may be beneficial in the prevention of Age-related Macular Degeneration (AMD).

Official Title
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Effect of Consumption of Eggs Rich in Xanthophyll Carotenoids and Omega-3 Fatty Acids on the Macular Pigment in Healthy People

Conditions
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Age-related Macular Degeneration

Intervention / Treatment
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* Other: Nutritional study


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: healthy subjects (male or female), 18 to 55 years Having signed the consent form, Susceptible to accept the stresses generated by the study, Insured. Exclusion Criteria: Corrected Visual Acuity <8/10th, History of cardiovascular disease, specifically coronary heart disease, Characterized dyslipidemia * Total cholesterol ³ 2.50 g / L, and / or triglycerides ³ 2.00 g / L Lipid-lowering treatment, Current smoking or person who stopped smoking less than 6 months Cataract or cataract surgery, Diabetes Body Mass Index (BMI)> 30 kg/m2, Taking food supplements in the 3 months preceding the start of the study (carotenoids, omega-3 fatty acids, phytosterols), Regular consumption in the three months preceding the start of the study products with added phytosterols. Regular consumption of high fatty fish or shellfish rich in omega-3 (4x a week or more): salmon, sardines, mackerel, herring, trout, tuna, red mullet, sea bass, bream, farmed turbot, mussels, squid / squid, anchovies. Allergy to eggs Dieting Difference significant weight over the last 3 months (> 3 kg) Inability to understand or adhere to the protocol Persons deprived of liberty People in a position to judicial protection Pregnant Women.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: rich-eggs<br>subjects consume 2 eggs rich in lutein/zeaxanthin and DHA per day during 4 months | Other: Nutritional study<br>* subjects consume 2 eggs per day during 4 months<br>|
| Active Comparator: standard eggs<br>subjects consume 2 standard eggs per day | Other: Nutritional study<br>* subjects consume 2 eggs per day during 4 months<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change from baseline in optical density of macular pigment after 4 months of eggs consumption | optical density of macular pigment was measured with a Heidelberg Retinal Angiograph (HRA)specially modify for the measure of the pigment. | before the eggs consumption and four months afterwards | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change from baseline in lutein and zeaxanthin in plasma and lipoproteins after 4 months of egg consumption | lutein and zeaxanthin were measured by HPLC | before the eggs consumption and four months afterwards | 
| change from baseline in fatty acids in plasma and lipoproteins after 4 months of egg consumption | Fatty acids were measured by Gas Chromatography. | before the eggs consumption and four months afterwards | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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eggs, Optical Macular Pigment, Age Macular Degeneration, study for the Age Macular Degeneration prevention