Chronic Obstructive Pulmonary Disease

Study Overview
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Brief Summary
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Chronic Obstructive Pulmonary Disease (COPD) is a preventable respiratory characterized by airflow obstruction that is not fully reversible. This disease a major cause of mortality worldwide. It is projected to rank the third-leading cause of death in 2020. The objective of this study is to examine the effects of a physical therapy intervention in stable patients with COPD.

Detailed Description
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Chronic obstructive pulmonary disease (COPD) patients have demonstrated important balance impairment (1).The deficit in balance control is identified as one of the risk factors of fall in subjects with COPD and alters their activities daily life (2,3). Porto and al. (2015) reported in a recent review that individuals with COPD have a decline in balance control when compared with healthy age matched controls(4).

Official Title
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The Effect of Adding Neuromuscular Electrical Stimulation to Endurance and Resistance Training on Exercise Capacity and Balance in Patients With Chronic Obstructive Pulmonary Disease: a Randomized Clinical Trial

Conditions
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COPD

Intervention / Treatment
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* Other: ET+RT+ NMES


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: COPD diagnosed by pulmonary function testing Clinically stable Abscence of other obstructive diseases Signed written consent Fall in the past five years or recent near fall Exclusion Criteria: Neuromuscular diseases Severe psychiatric, neurologic or musculoskeletal conditions and /or instable cardiovascular diseases. Contre-indications to physical therapy Acute exacerbations a month before the intervention

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Differents groups received differents training protocoles during the same duration
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: ET+RT+ NMES<br>neuromuscular electrical training NMES | Other: ET+RT+ NMES<br>* Endurance training, resistance training and neuromuscular electrical stimuation were prformed. Intensity was gradually increased.<br>|
| Placebo Comparator: ET+RT<br>placebo neuromuscular electrical training NMES | Other: ET+RT+ NMES<br>* Endurance training, resistance training and neuromuscular electrical stimuation were prformed. Intensity was gradually increased.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Balance outcomes | The tests were performed using a stabilometric platform | baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pulmonary function test | The test was performed using a Spirometry Zan 100 (Inspire Health GmbH, Germany) | baseline | 
| Exercise tolerance | The 6 minutes walk test | baseline | 
| Force assesment | Maximal voluntary contraction (MVC) of the quadriceps muscle | Baselline | 
| Time Up and Go (TUG) | The patient initially sitting on an armless chair stand up walks 3 meters and returns and sit down again. The time was recorded | Baseline | 
| Berg Balance Scale (BBS) | The BBS contains 14 items. The score obtained from 0 to 56. from 0 to 20: high risk of falling , Above 56: No risk of falling | Baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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COPD, Exercise training