Effect of Haemodialysis on the Efficacy of Antiplatelet Agents

Study Overview
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Brief Summary
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The main purpose of our study is to investigate whether haemodialysis itself affects the efficacy of antiplatelet drugs and the effects of two different types of dialysis membranes (polysulfone membranes and polyamide membranes) on antiplatelet efficacy. A total of 60 patients with ESRD and under dual-antiplatelet treatmen for at least 5 days will be enrolled and divided into the Clopidogrel group (clopidogrel 75mg qd;aspirin 100mg qd, n=30) and the Ticagrelor group (ticagrelor 90mg bid; aspirin 100mg qd, n=30). All included patients will receive haemodialysis by two different types of dialysis membrane.Platelet aggregation of venous blood from all patients will be detected by LTA and VerifyNow immediately before and after two times of haemodialysis.

Official Title
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Effect of Haemodialysis on the Efficacy of Antiplatelet Agents

Conditions
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Hemolysis, Renal Failure, Coronary Artery Disease

Intervention / Treatment
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* Device: Clopidogrel group;Ticagrelor group


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: diagnosis of coronary heart disease including stable angina, unstable angina, acute myocardial infarction taking dual antiplatelet drugs (clopidogrel 75mg qd + aspirin 100mg qd or ticagrelor 90 mg,bid + aspirin 100 mg,qd) at least 5 days haemodialysis patients sign informed consent Exclusion Criteria: platelet count>450 × 10 9 /L or <100 × 10 9 /L using IIb / IIIa inhibitor drugs within 10days taking nonsteroidal anti-inflammatory drugs other than aspirin hemorrhagic disease allergic to aspirin, ticagrelor or clopidogrel other factors may affect the results of this study
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Clopidogrel<br>clopidogrel 75mg qd;aspirin 100mg qd, n=30 | Device: Clopidogrel group;Ticagrelor group<br>* A total of 60 patients with ESRD and under dual-antiplatelet treatmen for at least 5 days will be enrolled and divided into the Clopidogrel group (clopidogrel 75mg qd;aspirin 100mg qd, n=30) and the Ticagrelor group (ticagrelor 90mg bid; aspirin 100mg qd, n=30). All included patients will receive haemodialysis by two different types of dialysis membrane.Platelet aggregation of venous blood from all patients will be detected by LTA and VerifyNow immediately before and after haemodialysis.<br>|
| Ticagrelor<br>ticagrelor 90mg bid; aspirin 100mg qd, n=30 | Device: Clopidogrel group;Ticagrelor group<br>* A total of 60 patients with ESRD and under dual-antiplatelet treatmen for at least 5 days will be enrolled and divided into the Clopidogrel group (clopidogrel 75mg qd;aspirin 100mg qd, n=30) and the Ticagrelor group (ticagrelor 90mg bid; aspirin 100mg qd, n=30). All included patients will receive haemodialysis by two different types of dialysis membrane.Platelet aggregation of venous blood from all patients will be detected by LTA and VerifyNow immediately before and after haemodialysis.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| using light transmittance aggregometer to detect whether haemodialysis can affect the efficacy of antiplatelet agents | intravenous blood collection with anticoagulant tube before and after haemodialysis respectively ；using light transmittance aggregometer to detect adenosine diphosphate induced platelet aggregation rate and arachidonic acid induced platelet aggregation rate within two hours after blood collection;;compare the outcome of light transmittance aggregometer with VerifyNow | collecting blood within 10 miuntes before and after haemodialysis;detecting them within 2 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| using VerifyNow to detect whether haemodialysis can affect the efficacy of antiplatelet agents | intravenous blood collection with VeryfiNow to detect the platelet reaction unit before and after haemodialysis respectively | collecting blood within 10 miuntes before and after haemodialysis;detecting them within 2 hours |