Removal of Beta Blocker Drugs by Hemodialysis

Study Overview
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Brief Summary
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Eight maintenance hemodialysis patients are given one of four beta blocker drugs (atenolol, bisoprolol, carvedilol, metoprolol) three hours prior to a hemodialysis session. Blood samples and spent dialysate are collected during dialysis. On separate dialysis sessions, patients received the other study drugs until they have taken each of the four study drugs. Dialytic clearance is calculated.

Official Title
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Beta-blocker Dialyzability in Maintenance Hemodialysis Patients

Conditions
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Chronic Kidney Diseases

Intervention / Treatment
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* Drug: Beta blocker


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: at least 18 years of age, receiving hemodialysis three times per week for at least 90 days. Exclusion Criteria: gastrointestinal or liver disease, body mass index greater than 40 kg/m2, contraindications for receiving a beta blocker (treatment with contraindicated medications, prior adverse reaction, severe reactive airway disease, hemodynamic instability during dialysis).

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Atenolol<br>Atenolol (50 mg) administered 3 hours prior to a hemodialysis session. Blood samples are collected a multiple times during dialysis and spent dialysate is collected at the end of the dialysis session. | Drug: Beta blocker<br>* Beta blockers are administered as described in arms.<br>|
| Experimental: Bisoprolol<br>Bisoprolol (5 mg) administered 3 hours prior to a hemodialysis session. Blood samples are collected a multiple times during dialysis and spent dialysate is collected at the end of the dialysis session. | Drug: Beta blocker<br>* Beta blockers are administered as described in arms.<br>|
| Experimental: Metoprolol<br>Metoprolol (50 mg) administered 3 hours prior to a hemodialysis session. Blood samples are collected a multiple times during dialysis and spent dialysate is collected at the end of the dialysis session. | Drug: Beta blocker<br>* Beta blockers are administered as described in arms.<br>|
| Experimental: Carvedilol<br>Carvedilol (6.25 mg) administered 3 hours prior to a hemodialysis session. Blood samples are collected a multiple times during dialysis and spent dialysate is collected at the end of the dialysis session. | Drug: Beta blocker<br>* Beta blockers are administered as described in arms.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Dialytic Clearance | Dialytic clearance calculated by the recovery clearance method | Through study completion, average of one year. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Dialytic Clearance | Dialytic clearance calculated by the arteriovenous difference method | Through study completion, average of one year. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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hemodialysis, dialytic clearance, pharmacokinetics