Metabolic Syndrome and Male Infertility

Study Overview
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Brief Summary
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Multidisciplinary, multicentric, cross-sectional study on men in infertile couples who conduct their sperm test through their diagnosis of infertility

Detailed Description
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Assessment of sperm parameters and metabolic syndrome relations in men attending a Reproductive Biomedicine centre for an infertility of their couple. Secondary objectives are to study relationship between sperm parameters and: adiposity and insulin resistance inflammation oxydative stress in blood and semen hormonal status Innovative parameters will also be assessed to determine the quality of semen (length of fingers, wrist circumference and epigenetics studies)

Official Title
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Relationship Between Sperm Parameters and Metabolic Syndrome in a Infertile Couple Partner Man

Conditions
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Male Infertility

Intervention / Treatment
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* Other: Blood sample, sperm sample and clinical examens


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 18 to 45 years-old man man consulting for primary or secondary infertility, with or without earlier notion of paternity patient insured with a social security scheme patient who have had a prior medical consultation patient who have done informed and written consent to participate in the research study Exclusion Criteria: patient with problems understanding French patient smoking more than two-pack-a-day patient monitoring for viral risk. man with an unidiopathic infertility which may be explained by: 1) identifiable factors in direct questioning at the sperm analysis: exposure to toxic products infectious disease history pathological anatomical background 2) factors identified at the etiologic investigation: cytogenetic and genetic

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Infertile men<br>Man partner of an infertile couple. Blood sample, sperm sample and clinical examens will be done at the day of the inclusion | Other: Blood sample, sperm sample and clinical examens<br>* Blood sample, sperm sample and clinical examens will be done at the day of the inclusion<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of spermatozoid and their relation with syndrome metabolic parameters | We will measure the parameters of metabolic syndrome (triglycerides, HDL and LDL cholesterol, systolic and diastolic blood pressure, fasting glucose) and correlate them with the number of spermatozoid . | Day 0 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Relationship between spermogram and spermocytogram and other metabolic parameters | Relationship between other spermogram/spermocytogram and metabolic markers (biomarkers and anthropometric adiposity and insulin resistance) | Day 0 | 
| Environmental parameters | Evaluation of environmental parameters (physical activity, tobacco consumption, quality of life) by classical questionnaire | Day 0 | 
| Relationship between spermogram and spermocytogram and other metabolic parameters | Relationship between other spermogram/spermocytogram and markers of inflammation | Day 0 | 
| Relationship between spermogram and spermocytogram and other metabolic parameters | Relationship between other spermogram/spermocytogram and markers of oxidative stress (plasma, seminal genetic polymorphisms involved in oxidative stress, genetic analyzes of sperm) | Day 0 | 
| Relationship between spermogram and spermocytogram and other metabolic parameters | Relationship between other spermogram/spermocytogram and hormonal markers | Day 0 | 
| Relationship between spermogram and spermocytogram and other metabolic parameters | Relationship between other spermogram/spermocytogram and innovative settings (studies epigenetic finger length and width of the wrist) | Day 0 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Metabolic syndrome, Epigenetic, Male infertility, Sperm parameters, Biomarkers