Imaging Non-brain Electromagnetic Activity in Healthy Adults Using MEG

Study Overview
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Brief Summary
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The primary purpose of this study is to determine the effectiveness of the Magnetoencephalography (MEG) instrument to record electrical activity from parts of the body other than the brain. This study will examine if electrical activity from parts of the body, other than the brain, can be imaged by the MEG instrument. Finding will contribute to studies of pain, since abnormal electrical activity in skeletal muscle is the basis of pain, which can be severe, yet there is no non-invasive way to image this abnormal activity. This is particularly relevant to deep muscle pain and back pain.

Official Title
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Imaging Non-brain Electromagnetic Activity in Healthy Adults Using MEG

Conditions
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Chronic Pain

Intervention / Treatment
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* Diagnostic Test: Whole-cortex MEG System (with optional EEG)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy adults who are willing and able to provide informed consent. Exclusion Criteria: Subjects with characteristics incompatible with MEG recordings as listed on the MEG Safety checklist (Appendix A), Involuntary, uncontrolled tremor, chronic pain. pregnant women (based on self-report).

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Device Feasibility
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: MEG Recording<br>Magnetic fields will be recorded using a 275-channel whole-head MEG system | Diagnostic Test: Whole-cortex MEG System (with optional EEG)<br>* Whole-Cortex MEG System non- invasively measures the magnetoencephalographic (MEG) signals (and, optionally, electroencephalographic EEG signals) produced by electrically active tissue of the brain. These signals are recorded by a computerized data acquisition system, displayed, and may then be interpreted by trained physicians to help localize these active areas. The location may then be correlated with anatomical information of the brain. MEG is routinely used to identify the locations of visual, auditory, somatosensory, and motor cortex in the brain.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Determination of optimal position to obtain safe and effective imaging of structures other than the brain. | Hand position 1 relaxed Hand position 1 muscles active Hand position 2 relaxed Hand position 2 muscles active Neck and Jaw, relaxed Neck and Jaw, tensed Upper torso relaxed Area of interest 1 relaxed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.) Area of interest 1 tensed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.) Area of interest 2 relaxed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.) Area of interest 2 tensed (areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.) | 2 Weeks | 
| Evoked activity to obtain safe and effective imaging of structures other than the brain | Hand position 1 relaxed Hand position 1 muscles active Hand position 2 relaxed Hand position 2 muscles active Neck and Jaw, relaxed Neck and Jaw, tensed Upper torso relaxed Area of interest 1 relaxed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.) Area of interest 1 tensed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.) Area of interest 2 relaxed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.) Area of interest 2 tensed (areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.) | 2 Weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Dominant frequency of non-brain electrical activity in healthy adults. | Hand position 1 relaxed Hand position 1 muscles active Hand position 2 relaxed Hand position 2 muscles active Neck and Jaw, relaxed Neck and Jaw, tensed Upper torso relaxed Area of interest 1 relaxed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.) Area of interest 1 tensed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.) Area of interest 2 relaxed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.) Area of interest 2 tensed (areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.) | 2 Weeks | 
| Location of non-brain of activity in healthy adults. | Hand position 1 relaxed Hand position 1 muscles active Hand position 2 relaxed Hand position 2 muscles active Neck and Jaw, relaxed Neck and Jaw, tensed Upper torso relaxed Area of interest 1 relaxed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.) Area of interest 1 tensed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.) Area of interest 2 relaxed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.) Area of interest 2 tensed (areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.) | 2 Weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Magnetoencephalography, Whole-cortex MEG System (with optional EEG)