Comparison of Brachial Artery Dilatation, Uterine Artery Doppler, Umbilical Artery Doppler and 1st-trimester Visceral Adipose Tissue Measurement in Obese and Normal Pregnant Women

Study Overview
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Brief Summary
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Brachial artery flow-mediated in obese and normal-weight pregnant women dilation of uterine artery doppler and umbilical artery doppler results comparison of

Detailed Description
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The systemic inflammatory effect caused by obesity and vascular disorder It has been reported that it creates studies. Healthy Vascular Endothelial structure increases vascular tone by regulating nitric oxide (NO) release. Reduced nitric oxide production, reducing flexibility It has a facilitating effect on hypertensive diseases and other obstetric diseases. Endothelial function, which is a non-invasive, easily applicable, and reproducible method It can be detected by endothelium-dependent vasodilation. A good indicator of endothelial function in studies in which the brachial artery flow-mediated dilation (FMD) shown. Brachial artery blood pressure cuff at forearm level in normal healthy people with compression for 3-5 minutes 50 mmHg above systolic pressure, 60-120 seconds after loosening the cuff When measured later, individuals with healthy endovascular function and the brachial artery are also reactive hyperemia, and a 10% dilatation is expected. Many obstetric effects such as obesity preeclampsia, preterm labor, gestational diabetes, preterm labor Although it was found to be related to pathology, the relationship between them could not be determined exactly. Our study aimed to increase brachial artery dilatation in obese and normal pregnant women. By comparing, determine the level of nitric oxide and endovascular function. Also uterine Vascular structures of obesity by comparing vascular structures with artery and umbilical uterine dops examine the effect on Pregnant women between the ages of 18-40 who apply to the Diseases and Obstetrics outpatient clinic will be taken. 24-28. Brachial artery dilatation, uterine, and umbilical artery doppler between 11-14, 37-40w weeks between gestational weeks, and visceral adipose tissue measurement at first trimester will be examined.

Official Title
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Comparison of Brachial Artery Dilatation, Uterine Artery Doppler, Umbilical Artery Doppler and 1st-trimester Visceral Adipose Tissue Measurement in Obese and Normal Pregnant Women

Conditions
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Obese, Vascular Diseases, Pregnancy Related, Visceral Obesity

Intervention / Treatment
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* Other: ultrasonography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: obese and normal pregnant 11-14 weeks 24-28 weeks 37-40 weeks Exclusion Criteria: smoking chronic vascular disease Diabetes mellitus Over 40 years old

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Female

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 11-14 weeks of normal pregnancy.<br>11-14. Measurement of brachial artery flow dilatation in the arm during pregnancy weeks, Visceral adipose tissue measurement (armellini method), and maternal uterine artery dopes will be examined ultrasonographically. | Other: ultrasonography<br>* vascular and adipose tissue measurement by ultrasonography<br>|
| 11-14 week obese pregnant<br>11-14. Measurement of brachial artery flow dilatation in the arm during pregnancy weeks, Visceral adipose tissue measurement (armellini method), and maternal uterine artery dopes will be examined ultrasonographically. | Other: ultrasonography<br>* vascular and adipose tissue measurement by ultrasonography<br>|
| 24-28 week normal pregnant<br>24-28. Measurement of brachial artery flow dilatation in the arm during pregnancy weeks, fetal umbilical artery, and maternal uterine artery dopes will be examined ultrasonographically. | Other: ultrasonography<br>* vascular and adipose tissue measurement by ultrasonography<br>|
| 24w-28w obese normal pregnant<br>24w-28w. Measurement of brachial artery flow dilatation in the arm during pregnancy weeks, fetal umbilical artery and maternal uterine artery dopes will be examined ultrasonographically | Other: ultrasonography<br>* vascular and adipose tissue measurement by ultrasonography<br>|
| 37w -40w normal pregant<br>37w-40 w. Measurement of brachial artery flow dilatation in the arm during pregnancy weeks, fetal umbilical artery and maternal uterine artery dopes will be examined ultrasonographically | Other: ultrasonography<br>* vascular and adipose tissue measurement by ultrasonography<br>|
| 37-40 w obese normal pregnant<br>37w-40 w. Measurement of brachial artery flow dilatation in the arm during pregnancy weeks, fetal umbilical artery and maternal uterine artery dopes will be examined ultrasonographically | Other: ultrasonography<br>* vascular and adipose tissue measurement by ultrasonography<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To define the relationship between obesity and endovascular dysfunction by brachial artery dilatation method. | To examine the possible effects of obesity on the endovascular system with the brachial artery dilation method. | 3 month | 
| Measurement of uterine artery doppler in obese and normal pregnant women | To determine whether obesity has an effect on uterine artery resistance. | 3 month | 
| Measurement of obese and normal pregnant umbilical artery doppler | trying to understand whether obesity has fetal effects by examining umbilical artery doppler in obese pregnants and normal pregnants, | 3 month | 
| First trimester visceral adipose tissue and brachial artery measurement | By measuring the amount of visceral tissue in the first trimester obese and normal pregnant women with Armellini method; Investigation of its effects on endovascular dysfunction through brachial artery dilatation | 3 month |