Metabonomics Study of Chronic Gastritis and Gastric Carcinoma

Study Overview
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Brief Summary
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The pathogenetic mechanisms of chronic gastritis and gastric carcinoma are different. Whether metabonomics play a role in the development of chronic gastritis and gastric cancer is still a question. So the investigators want to clarify this question by this subject.

Detailed Description
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This project was an untargeted metabolomics study using liquid chromatography coupled with mass spectrometry (LC-MS) in patients with chronic gastritis and gastric carcinoma. The experimental procedures mainly include sample collection, metabolite extraction, LC-MS/MS detection, data analysis, etc.The goal of this study is to identify and (relatively) quantify as many metabolites in biological systems as possible, so as to reveal the overall metabolite information to the maximum extent. Metabolomics aims to investigate the changes of metabolites in gastric tissues in patients with chronic gastritis and gastric carcinoma, and to study the biological processes in which these metabolites participate by screening the different metabolites in the different groups, and to reveal the mechanism of life activities in which they involved in.

Official Title
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Metabonomics Study of Chronic Gastritis and Gastric Carcinoma

Conditions
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Gastric Cancer

Intervention / Treatment
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* Diagnostic Test: different diseases


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with chronic superficial gastritis and chronic atrophic gastritis Patients with gastric carcinoma Exclusion Criteria: Patients with history of surgery Patients with severe heart disease,lung disease or kidney disease.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with chronic superficial gastritis<br>Patients with chronic superficial gastritis | Diagnostic Test: different diseases<br>* Patients will be divided into three groups, including chronic superficial gastritis ,chronic atrophic gastritis and gastric carcinoma.<br>|
| Patients with chronic atrophic gastritis<br>Patients with chronic atrophic gastritis | Diagnostic Test: different diseases<br>* Patients will be divided into three groups, including chronic superficial gastritis ,chronic atrophic gastritis and gastric carcinoma.<br>|
| Patients with gastric carcinoma<br>Patients with gastric carcinoma | Diagnostic Test: different diseases<br>* Patients will be divided into three groups, including chronic superficial gastritis ,chronic atrophic gastritis and gastric carcinoma.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Metabonomic difference in patients with chronic gastritis and gastric carcinoma | 1.The different levels of metabolites in gastric tissues in patients with chronic gastritis and gastric carcinoma. 2. The common change model of metabolites in gastric carcionoma compared with chronic gastritis. | six months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Association of different metabolic substances and disease results in chronic gastritis and gastric carcinoma | The researchers want to reveal the relationship between different metabolic sustances and disease result in patientswith chronic gastritis and gastric carcinoma. | six months |