Diagnostic Accuracy of Nontuberculous Mycobacterial Lung Disease Based on Chest CT

Study Overview
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Brief Summary
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The aim of this study was to elucidate the accuracy and inter-rater agreement of diagnosis of nontuberculous mycobacterial lung disease based on chest computed tomography findings.

Detailed Description
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To elucidate the accuracy and inter-rater agreement of diagnosis of nontuberculous mycobacterial lung disease based on chest CT, two pulmonologists and two chest radiologists were requested to interpret chest CT of patients nontuberculous mycobacterial lung disease satisfying diagnostic criteria of American Thoracic Society as well as British Thoracic Society, or pulmonary tuberculosis. Two pulmonologists and two chest radiologists > 10 years of clinical experiences at a tertiary referral hospital participated as raters in this study. They were blinded to the any clinical information of the patients including the specific diagnosis, except age and sex. The interpretations of four raters were analyzed and compared.

Official Title
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Diagnostic Accuracy and Inter-rater Agreement of Chest Computed Tomography in the Diagnosis of Nontuberculous Mycobacterial Lung Disease

Conditions
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Mycobacterium Infections, Nontuberculous

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Nontuberculous mycobacterial patients satisfying diagnostic criteria suggested by American Thoracic Society Patients with bacteriologically confirmed pulmonary tuberculosis Patients with bronchiectasis, confirmed by clinically as well as radiographically Exclusion Criteria: None
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Nontuberculous lung disease<br>Patients with Nontuberculous Mycobacteria satisfying American Thoracic Society and British Thoracic Society guidelines | |
| pulmonary tuberculosis<br>Patients with culture confirmed tuberculosis | |
| bronchiectasis<br>Patients with bronchiectasis based on chest CT findings as well as symptoms | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sensitivity for the diagnosis of nontuberculous mycobacterial lung disease | Percentage of cases diagnosed as nontuberculous mycobacterial lung disease by four raters out of confirmed cases with nontuberculous mycobacterial lung disease | baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Inter-rater correlation (kappa value) for the diagnosis of nontuberculous mycobacterial lung disease | Inter-rater correlation between four raters | baseline | 
| Specificity for the diagnosis nontuberculous mycobacterial lung disease | Percentage of cases diagnosed as other than nontuberculous mycobacterial lung disease by four raters out of confirmed cases with other than nontuberculous mycobacterial lung disease | baseline |