Determination of the Red Cell Distribution Width, NT-proBNP and cTnT in Acute Myocardial Infarction Patients

Study Overview
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Brief Summary
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the study is to investigate the relationship of several parameters of complete blood count (CBC) including RDW with N-terminal pro-B-type natriuretic peptide (NT-proBNP) and cardiac troponin T (cTnT) in a cohort of acute myocardial infarction (AMI) patients.

Detailed Description
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Patients and methods: Type of study: Observational prospective study Place of study: Sohag cardiology and gastroenterology center, department of cardiology and cardiac care unit. Ethical considerations: This research will be revised by the Scientific Ethical Committee of Sohag University Hospital. Consents will be taken from all patients. Study Methods: A prospective study on 30 patients diagnosed as acute myocardial infarction on which measurement of CBC, serum NT-proBNP, and cTnT levels will be performed at the time of admission and by the time of discharge. Full history: Personal history: e.g. age, sex and smoking. Family history of cardiac diseases Medical history of: Hypertension, Ischemic heart disease, prior coronary artery bypass grafting, Prior Percutaneous coronary intervention, Prior Stroke, Prior Atrial fibrillation, therapeutic history Detailed clinical examination Electrocardiogram Laboratory investigation: Routine investigation in the form of CBC including RDW Specific investigation which include NT-proBNP and cTnT

Official Title
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Determination of the Relationship Between Red Cell Distribution Width, NT-proBNP and cTnT in Acute Myocardial Infarction Patients

Conditions
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Myocardial Infarction

Intervention / Treatment
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* Diagnostic Test: CBC
* Diagnostic Test: (NT-proBNP)
* Diagnostic Test: (cTnT)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients diagnosed as acute myocardial infarction Exclusion Criteria: Patient with Decompensated heart failure Pulmonary hypertention Acute pulmonary embolism Septic shock

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: CBC|measurement of CBC will be performed at the time of admission and by the time of discharge|
|Diagnostic Test: (NT-proBNP)|measurement of serum NT-proBNP levels will be performed at the time of admission and by the time of discharge|
|Diagnostic Test: (cTnT)|measurement of cTnT levels will be performed at the time of admission and by the time of discharge|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| complete blood count (CBC) | measurement of CBC levels will be performed | 7 months | 
| Level of (NT-proBNP) | measurement of serum NT-proBNP level will be performed | 7 months | 
| Level of (cTnT) | measurement of cTnT level will be performed | 7 months |