Laser Therapy Versus Electrosurgery For Nasal Telangiectasias

Study Overview
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Brief Summary
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The aim of this study is to compare the efficacy of various treatment options for eliminating nasal telangiectasias. The study will compare the outcome of treating nasal telangiectasias with the following; no treatment (control site), alexandrite laser, pulsed dye laser, combination pulsed dye laser and Nd:YAG 1064nm multiplex laser system and electrosurgery.

Official Title
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Evaluation of Laser Therapy Vs Electrosurgery For Nasal Telangiectasias Using A Novel Vascular Imaging Device

Conditions
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Telangiectasis

Intervention / Treatment
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* Device: Pulsed Dye Laser
* Device: Long Pulsed Alexandrite Laser
* Device: Pulsed Dye Laser Plus Nd:YAG Laser
* Procedure: Electrodesiccation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Over 18 years of age Able to give informed consent themselves Willing to return for follow up visit 0.5 - 3 millimeter Vessel size 5 Non-contiguous nasal vascular lesions Exclusion Criteria: Mentally handicapped Unable to understand written and oral English Incarceration Under 18 years of age Unwilling to return for follow up Pregnant Women Vessels less than 0.5 millimeter caliber Less than 5 non-contiguous vessels

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Pulsed Dye Laser<br>Subjects with multiple nose telangiectasias will be enrolled. One nose telangiectasia (of 5) will be treated with pulsed dye laser. | Device: Pulsed Dye Laser<br>* Pulsed dye laser treatments will be performed with a 595 nanometer wavelength, 20 millisecond pulse duration, at 10 Joules/cm2, with a 10 millimeter spot size.<br>* Other names: Pulsed dye laser treatments will be performed with a 595 nanometer wavelength, 20 millisecond pulse duration, at 10 Joules/cm2, with a 10 millimeter spot size.;|
| Active Comparator: Long Pulsed Alexandrite Laser<br>Subjects with multiple nose telangiectasias will be enrolled. One nose telangiectasia (of 5) will be treated with long pulsed alexandrite laser. | Device: Long Pulsed Alexandrite Laser<br>* Alexandrite laser will be used with a 755 nanometer wavelength, 40 millisecond pulse duration, at 88Joules/cm2, with a 6 millimeter spot size.<br>|
| Active Comparator: Pulsed Dye Laser Plus Nd:YAG Laser<br>Subjects with multiple nose telangiectasias will be enrolled. One nose telangiectasia (of 5) will be treated with pulsed dye laser plus Nd:YAG laser. | Device: Pulsed Dye Laser Plus Nd:YAG Laser<br>* The Cynergy with MultiPlex will be used with a multiplex mode system with a pulse dye laser at 585 nanometer wavelength, 20 milliseconds pulse duration, at 7 Joules/cm2 with a 7 millimeter spot size, with a short delay, followed by a Nd:YAG 1064 nanometer wavelength, 20 millisecond pulse duration, at 50 Joules/cm2 with a 7 millimeter spot size.<br>|
| Active Comparator: Electrodesiccation<br>Subjects with multiple nose telangiectasias will be enrolled. One nose telangiectasia (of 5) will be treated with electrodesiccation. | Procedure: Electrodesiccation<br>* A curette is used to scrape off the cancer down to the dermis. The scraping is then paused while an electrosurgical device like a hyfrecator is used next. Electrodesiccation is performed over the raw surgical ulcer to denature a layer of the dermis and the curette is used again over the surgical ulcer to remove denatured dermis down to living tissue.<br>|
| No Intervention: No Treatment<br>Subjects with multiple nose telangiectasias will be enrolled. One nose telangiectasia (of 5) will receive no treatment. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Reduction of Area of Nasal Telangiectasias by Laser Therapy Vs Electrosurgery | The study will measure the changes in length and width (area) of nasal telangiectasias before and after treatment with the following: no treatment (control site), alexandrite laser, pulsed dye laser, combination pulsed dye laser and Nd:YAG 1064nm multiplex laser system and electrosurgery. | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluation of Cosmetic Improvement | Percent perceived improvement for nasal vessels by the patient via questionnaire. | 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Nasal telangiectasis