Project AMD: Comprehensive Characterisation of Age-Related Macular Degeneration and Its Progression

Study Overview
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Brief Summary
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Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss worldwide, and nearly two million Australians have some signs of AMD. This proposed project is a prospective, observational study that seeks to to understand the underlying aetiology of AMD, factors associated with differences between age-related macular degeneration (AMD) phenotypes or severities, or between AMD and healthy individuals. It also seeks to understand the natural history of AMD progression and the factors associated with the rate of progression. In this project, the disease phenotype, genotype and severity and rate of progression will be determined based on non-invasive clinical imaging or functional assessment of the retina, from obtaining biological samples from the participants, or from patient-reported outcomes.

Official Title
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Project AMD: Comprehensive Characterisation of Age-Related Macular Degeneration and Its Progression

Conditions
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AMD, Age Related Macular Degeneration, Geographic Atrophy, Age-related Macular Degeneration

Intervention / Treatment
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* Other: N/A Observational study


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 18 years of age or older; and either AMD (defined as having at least a medium druse >63 um), or having eyes with normal ageing changes (including small drusen ≤63 um) or no abnormalities as control participants Exclusion Criteria: ocular or systemic conditions other than AMD that could compromise retinal assessment or assessment of AMD and its progression; or any participant with any mental or physical impairment that prevents them from signing an informed consent form or participating in this study.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Age-Related Macular Degeneration<br>Participants with Age-Related Macular Degeneration | Other: N/A Observational study<br>* N/A Observational study<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Investigate the underlying aetiology of Age-Related Macular Degeneration | The first aim of this project is to comprehensively investigate the underlying aetiology of AMD, characterise the AMD phenotype by understanding the differences between those with AMD and healthy individuals. | Up to 20 years | 
| Characterise the natural history of Age-Related Macular Degeneration and factors associated with its rate of progression. | The second aim of this project is to characterise the natural history of AMD and factors associated with its rate of progression. These aims will be achieved by using performing imaging and functional assessment of the retina, characterisation of the genetic, systemic and environmental factors, and by obtaining patient-reported outcomes. | Up to 20 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Age Related Macular Degeneration, Geographic Atrophy, Drusen, Macular disease