Postprandial Effects of a High Potassium Meal

Study Overview
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Brief Summary
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The investigators aim to evaluate the acute effects of potassium supplementation achieved by ingestion of potassium rich food, on vascular health.

Detailed Description
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Many studies have shown that an increase in potassium through the diet or through potassium pills helps to lower blood pressure. Also, the amount of oral potassium taken can improve how well the participants blood vessels work. These studies have focused on potassium given in the form of a pill. The investigators are interested in the effect of potassium consumed through food sources and how it will effect arterial health and blood pressure. The world health organization (WHO) recommends a K⁺ intake of at least 3510 mg/day from food for adults, excluding those with impaired K⁺ excretion. In this study the investigators aim to provide approximately 75% (approximately 2000 mg) of the total daily recommended intake for potassium in one meal. The investigators do not know whether dietary potassium (not pill form) will acutely improve the arterial health and if it will cause a decrease in blood pressure. The investigators hypothesis to see an improvement in vascular function following a high potassium meal compared to a low potassium meal.

Official Title
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Postprandial Physiological Effects of a High Potassium Meal in Patients With Hypertension

Conditions
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Hypertension

Intervention / Treatment
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* Other: High Potassium Meal
* Other: Low Potassium Meal


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 18-80 years Normal sinus rhythm A diagnosis of hypertension on medical therapy with an ambulatory systolic blood pressure <160 mmHg and diastolic blood pressure <90 mmHg, or a diagnosis of stable coronary artery disease Exclusion Criteria: Recent hospital admission due to an cardiovascular events Serum K+ concentration >5.0 mmol/L Current smoking Women who are pregnant Diabetic patients - patients receiving insulin therapy Glomerular filtration rate < 90mls/min/1.73m2 On loop diuretic therapy Food allergies and/or intolerance to meal items

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: High potassium meal<br>In this arm individuals will be provided with a breakfast meal that provides  2400 mg of dietary potassium. | Other: High Potassium Meal<br>* Breakfast meal that provides  2400 mg of dietary potassium. Meals are isocaloric.<br>|
| Active Comparator: Low potassium meal<br>In this arm individuals will be provided with a breakfast meal that provides  540 mg of dietary potassium. | Other: Low Potassium Meal<br>* Breakfast meal that provides  540 mg of potassium. Meals are isocaloric.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Flow Mediated Dilatation | Flow Mediated Dilatation is a method used to measure endothelial-dependent regulation of conduit artery tone(Joannides R, 1995). | Flow Mediated Dilatation will be assessed over 2 clinic visits, at 3 times points with in each visit; pre-prandial and post-prandial at 60 min and 120 min | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Dietary Potassium