Effects of Sedentary Behaviour on Metabolic Parameters

Study Overview
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Brief Summary
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The rates of sedentary activity are increasing. Studies have shown that time spent on doing sedentary activities is an independent risk factor for cardiovascular disease. Prior studies have shown that interrupting inactivity improved the body's handling of blood glucose and gene expression. The investigators plan to explore this further by examining the effects of interrupting 4 hours of inactivity with 2 minutes of moderate intensity exercise every 20 minutes on the following metabolic parameters: blood pressure, cortisol, C-Reactive Protein, glucose and insulin levels.

Detailed Description
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There is a current trend towards increasing time spent in sedentary behaviour. More jobs are being automated, and more time is spent in front of a computer, playing video games and watching television.Current studies suggest that sedentary behaviour is an independent risk factor for cardiovascular disease. Increasing time spent in sedentary behaviour has been linked to all-cause mortality, markers of cardiovascular disease and metabolic syndrome. However, the data is mainly from cross-sectional studies and based on self-recall, limiting the ability to draw definitive conclusions. Current exercise guidelines recommend at least 150 minutes of moderate to vigorous intensity exercise per week. It may be difficult for some elderly people to meet these guidelines. Older adults with diabetes are already at a higher risk fo conditions that are affected by sedentary behaviour and may stand to benefit the most from intervention. This study proposes to study the effects of breaking up sedentary activity with moderate intensity exercise on multiple metabolic parameters in older adults with diabetes.

Official Title
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Effects of Sedentary Behaviour on Metabolic Parameters

Conditions
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Sedentary Lifestyle, Type 2 Diabetes

Intervention / Treatment
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* Other: Inactivity
* Other: Activity


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 65 years of age or older type 2 diabetes managed with diet or oral hypoglycemic agents Exclusion Criteria: using insulin to manage diabetes baseline of pre-session blood glucose reading equal to or greater than 10 mmol/L any medical condition that would limit the ability to perform activity portion of the study people not comfortable exercising on a stationary bicycle subject answers yes to one of more of the questions in the Physical Activity Readiness Questionnaire

Ages Eligible for Study
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Minimum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Activity<br>During a 4 hour Meal Test subjects will cycle for 2 minutes every 20 minutes | Other: Activity<br>* Subjects will spend 4 hours of inactivity (lying on a bed) broken up by 2 minutes of moderate intensity biking (on a stationary bike) every 20 minutes.<br>|
| Other: Inactivity<br>During a 4 hour Meal Test study subjects will remain inactive (remain lying on a bed) | Other: Inactivity<br>* Subjects will remain inactive (lying on a bed) for 4 hours.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood Pressure |  | every 60 minutes for 4 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| C Reactive Protein |  | every 60 minutes for 4 hours | 
| Insulin Levels |  | every 60 minutes for 4 hours | 
| Blood glucose levels |  | every 60 minutes for 4 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Exercise, Sedentary Behaviour, Type 2 Diabetes, Older Adults