Effects of Smoking Environment on Craving and Smoking

Study Overview
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Brief Summary
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The goal of this study is to evaluate the effects of exposure to standard smoking environments on ability to resist smoking as measured with a Delay to Smoking Task. The results of this study will inform whether the Delay to Smoking Task is a sensitive measure for evaluating environment-provoked craving and smoking behavior.

Detailed Description
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Adult smokers (n=25) will complete 4 visits and a 6 month follow-up phone call. Participants will complete a Delay to Smoking Task following 6 hours smoking abstinence. The task involves viewing pictures of smoking and non-smoking locations and participants will have the choice to smoke a cigarette at any time during the session. A monetary reinforcer will be provided for each 6-minute period that a participant resists smoking. Once participants stop the task they can choose to smoke as much or a little as they want for the next 30 minutes. Participants will be provided with a smoking tab. Each cigarette they light will cost them from their tab. Measurements of tobacco craving, emotion ratings, and nicotine withdrawal will be assessed.

Official Title
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Effects of Smoking Environment on Craving and Smoking: A Pilot Study

Conditions
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Smoking

Intervention / Treatment
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* Behavioral: 6 hour smoking abstinence
* Behavioral: Delay to Smoking Task (smoking cues)
* Behavioral: Delay to Smoking Task (nonsmoking cues)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: generally healthy between the ages of 18 and 55 smoking an average of 5 cigarettes per day for at least one year breath CO level > 8 ppm (if ≤ 8 ppm, then NicAlert Strip = 6) no interest in quitting smoking for the duration of time required for the experiment Exclusion Criteria: inability to attend all required experimental sessions use of psychoactive medications use of smokeless tobacco current alcohol or drug abuse use of illegal drugs as measured by urine drug screen (excluding marijuana) current use of nicotine replacement therapy or other smoking cessation treatment Blood Alcohol Level (BAL) > 0.00 use of other tobacco products or e-cigarettes more than 9 days in the past 30 days

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: 6 hour smoking abstinence|nan|
|Behavioral: Delay to Smoking Task (smoking cues)|Participants will be presented with an unlit cigarette of their brand and an opportunity to initiate ad lib smoking at any time during the 60-minute task. During this period, participants will be allowed to read books or magazines, but will hear a tone alerting them to view cues (standard smoking environments) for the final minute of each 6-minute period. A monetary reinforcer will be provided for each 6-minute period that a participant resists smoking. Once participants stop the task they can choose to smoke as much or a little as they want for the next 30 minutes. Participants will be provided with a smoking tab. Each cigarette they light will cost them from their tab.|
|Behavioral: Delay to Smoking Task (nonsmoking cues)|Participants will be presented with an unlit cigarette of their brand and an opportunity to initiate ad lib smoking at any time during the 60-minute task. During this period, participants will be allowed to read books or magazines, but will hear a tone alerting them to view cues (standard nonsmoking environments) for the final minute of each 6-minute period. A monetary reinforcer will be provided for each 6-minute period that a participant resists smoking. Once participants stop the task they can choose to smoke as much or a little as they want for the next 30 minutes. Participants will be provided with a smoking tab. Each cigarette they light will cost them from their tab.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in self-report craving measured by the cue-exposure rating scale |  | at 0 minutes, +30 minutes, +60 minutes and following first cigarette | 
| Difference in number of subjects who initiate smoking during the smoking cue Delay to Smoking Task compared to the nonsmoking cue Delay to Smoking Task | If participant initiates smoking a cigarette during the Delay to Smoking Task | following start of Delay to Smoking Task, up to 60 minutes | 
| Number of minutes to first puff | Number of minutes to first puff of cigarette will be recorded for participants that initiate smoking | following start of Delay to Smoking Task, up to +60 minutes |