The Glycemic Effect of Added Sugar on Bake Beans

Study Overview
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Brief Summary
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To investigate the effect of added sugar to bake beans on glycemic and insulinemic response.

Detailed Description
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There will be a total of 7 test session. Each session will last for 3 hours. At each test session, volunteers will be served with 7 test meals and blood will be collected. After an overnight fast, subjects will visit the research center. Two fasting capillary blood samples will be collected via fingerpick. Following the fasting samples, volunteers will consume the test meals. Further blood samples will be collected at 15, 30, 45, 60, 90, 120, 150, 180 minutes after the ingestion of test meal. These samples will be used to analyses for whole capillary blood glucose. At every 30 minute interval, samples will be collected for analysis of capillary plasma insulin.

Official Title
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The Glycemic Effect of Added Sugar on Bake Beans

Conditions
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Diabetes Mellitus, Type 2, Obesity, PreDiabetes

Intervention / Treatment
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* Other: Glucose Reference 1
* Other: Glucose Reference 2
* Other: Glucose reference 3
* Other: Sucrose
* Other: Regular Bake beans in tomato sauce
* Other: Bake beans in tomato sauce, reduced sugar
* Other: Bake beans in tomato sauce, low GI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Chinese ethnicity Age ≥21 and ≤ 60 years Body mass index between 18.5 to 25 kg/m2 Normal blood pressure <140/90 mmHg Fasting blood glucose <6.0 mmol/L In general good health Exclusion Criteria: Current Smoker have any metabolic diseases (such as diabetes, hypertension etc) have known glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency) having medical conditions and/or taking medications known to affect glycaemia (glucocorticoids, thyroid hormones, thiazide diuretics) have intolerances or allergies to any foods partake in sports at the competitive and/or endurance levels intentionally restrict food intake

Ages Eligible for Study
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Minimum Age: 21 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Crossover Assignment
Interventional Model Description: Crossover randomized controlled Trials
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Glucose Reference 1<br>Glucose solution containing 30 g of glucose | Other: Glucose Reference 1<br>* 30 g of glucose dissolved in 250 ml of water<br>|
| Other: Glucose Reference 2<br>Glucose solution 2 containing 30 g of glucose | Other: Glucose Reference 2<br>* 30 g of glucose dissolved in 250 ml of water<br>|
| Other: Glucose Reference 3<br>Glucose solution 3 containing 30 g of glucose | Other: Glucose reference 3<br>* 30 g of glucose dissolved in 250 ml of water<br>|
| Experimental: Sucrose<br>Sucrose solution containing 30 g of sucrose | Other: Sucrose<br>* 30 g of Sucrose dissolved in 250 ml of water<br>|
| Experimental: Regular Bake beans in tomato sauce<br>Bake bean in tomato sauce with high levels of sucrose (37%) | Other: Regular Bake beans in tomato sauce<br>* Bake beans in tomato sauce containing 14 g of sugar<br>|
| Experimental: Bake beans in tomato sauce, reduced sugar<br>Bake bean in tomato sauce with medium levels of sucrose (29.9%) | Other: Bake beans in tomato sauce, reduced sugar<br>* Bake beans in tomato sauce containing 12.2 g of sugar<br>|
| Experimental: Bake beans in tomato sauce, low GI<br>Bake bean in tomato sauce with low levels of sucrose (18.5%) | Other: Bake beans in tomato sauce, low GI<br>* Bake beans in tomato sauce containing 7.2 g of sugar<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Glucose [ | Whole capillary blood glucose will be measure using Hemocue analyser | Up to 180 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Insulin | Capillary plasma will be measure using Cobas analyser | Up to 180 minutes |