Accelerated Aging in Middle-Aged Men With Sleep-disordered Breathing.

Study Overview
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Brief Summary
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Obstructive Sleep Apnea Syndrome (OSAS) regardless of any other associated risk factor can lead to accelerated aging. The study of aging-related Obstructive Sleep Apnea (OSA) is difficult because of associated risk factors (diabetes, hypertension, dyslipidemia, obesity), promoting themselves aging. The investigators propose to compare a group of OSAS patients free of any associated pathology, to subjects matched for age, sex, smoking and body mass index (BMI)

Official Title
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Accelerated Aging in Middle-Aged Men With Sleep-disordered Breathing.

Conditions
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Obstructive Sleep Apnea

Intervention / Treatment
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* Other: Polysomnography , blood collection, bone densitometry and Functional respiratory explorations


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria Patient: Men aged 20 to 65 years Having polysomnography in the Functional Explorations department, Sleep Laboratory, Hospital Henri Mondor, Creteil With an AHI > 5 / h Healthy volunteers: Men aged 20 to 65 years With an AHI ≤ 5 / h Exclusion Criteria All subjects: Known cardiovascular risk: hypertension treated, diabetes treated, dyslipidemia treated, Known cardiovascular disease associated (heart failure, rhythm disorder ...) Known respiratory diseases Known neoplastic pathology, known chronic inflammatory disease Psychiatric pathology treated Medication Not affiliated to the French social health care system Major protected person Private person of liberty People in emergency situation Patient refusing to participate in the study

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Severe OSA<br>Patients with severe OSA (AHI > 30) | Other: Polysomnography , blood collection, bone densitometry and Functional respiratory explorations<br>* Blood collection, Bone densitometry and Functional respiratory explorations are a specific interventions of protocol for the 3 arms. Polysomnography is a specific intervention for the arms  healthy volunteers <br>|
| Other: Moderate OSA<br>Patients with moderate OSA (5 < AHI ≤ 30) | Other: Polysomnography , blood collection, bone densitometry and Functional respiratory explorations<br>* Blood collection, Bone densitometry and Functional respiratory explorations are a specific interventions of protocol for the 3 arms. Polysomnography is a specific intervention for the arms  healthy volunteers <br>|
| Other: Healthy volunteers<br>Healthy volunteers (AHI ≤ 5) | Other: Polysomnography , blood collection, bone densitometry and Functional respiratory explorations<br>* Blood collection, Bone densitometry and Functional respiratory explorations are a specific interventions of protocol for the 3 arms. Polysomnography is a specific intervention for the arms  healthy volunteers <br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Telomere length of circulating leukocytes |  | 4 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Carotid-femoral pulse wave velocity |  | 4 weeks | 
| Bone density |  | 4 weeks | 
| Correlation between biological parameters and neuropsychological assessment |  | 4 weeks | 
| Markers of oxidative stress: Malondialdehyde, heme oxygenase-1 |  | 4 weeks | 
| Markers of inflammation: hs-CRP, IL-6, IL-8, MCP-1 |  | 4 weeks | 
| Markers of growth hormone axis (GH, IGF-1, IGFBP) |  | 4 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Obstructive sleep apnea, Aging, Telomere length