The Relationship Between Motor Cortex Oxygenation and Motor Function Recovery in Stroke Patients

Study Overview
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Brief Summary
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Stroke is the most common cause of motor function impairment. However, the functional impairment is not totally irreversible. Several mechanisms may involved in both the cortical and motor function recovery after onset of stroke, and most of them are related to changes of cortical perfusion and metabolism. Motor function recovery after stroke (especially middle cerebral artery territory lesion) frequently follow stereotypic pattern (brunnström stage). This study is designed to investigate the relationship between motor cortex oxygenation/metabolism and motor function recovery after stroke. To seek if there is similar stereotypic pattern of motor cortex oxygenation/metabolism change during the recover stage after stroke.

Detailed Description
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Participants receive evaluations (1/week for 3 months period) of motor function (Include: MMSE, brunnström stage, Fugl-Meyer Assessment of Physical Performance, Box and Block Test of Manual Dexterity, Functional Independence Measure) cortical perfusion detection during performing limb movements (using NIRS) Then use path analysis to investigate the relationship between motor cortex oxygenation/metabolism and motor function recovery after stroke.

Official Title
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The Relationship Between Motor Cortex Oxygenation and Motor Function Recovery in Stroke Patients

Conditions
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Stroke

Intervention / Treatment
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* Procedure: Functional Electric Stimulation
* Other: Rehabilitation programs


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Ischemic stroke(unilateral, onset within 7 days, without previous stroke history) Vital sign stable Upper extremity motor function impairment(brunnström stage I III) Exclusion Criteria: with pacemakers Seizure history Serious dysrhythmias Poor cognition function(MMSE<13)

Ages Eligible for Study
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Minimum Age: 45 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Functional Electric Stimulation<br>perform arm cranking with functional electrical stimulation | Procedure: Functional Electric Stimulation<br>* apply to the hemiplegia affected limbs, helping movement<br>|
| Sham Comparator: traditional rehabilitation program<br>Receive traditional rehabilitation programs | Other: Rehabilitation programs<br>* include occupational therapy and physical therapy<br>|
| No Intervention: Health<br>with no motor function impairment | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cortical activation | Using Near-infrared spectroscopy to measure cortical activation changes weekly for 3 months | weekly changes within 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| motor function | assess motor function every week for 3 months | weekly changes within 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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cortical activation, motor function, activity of daily living