Muscle Metabolic Function in Older Adults With Different Vitamin D Status Before and After Exercise

Study Overview
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Brief Summary
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This is a small pilot aerobic training trial designed to examine differences between normal-high and low vitamin D levels and 7-days of aerobic training on local VO2 measured by non-invasive Hybrid Diffuse Optical Spectroscopy.

Official Title
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A Pilot Study Investigating Differences in Muscle Metabolic Function in Individuals Aged 65-75 Years With Different Vitamin D Status Before and After 7-days of Aerobic Training

Conditions
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Vitamin D Deficiency

Intervention / Treatment
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* Other: 7 continuous days of aerobic training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 65-75 years of age Exclusion Criteria: Currently have or have a history of cardiovascular or pulmonary disease that would preclude the involvement in the performance of exercise. Uncontrolled diabetes or hypertension. History of neurological conditions related to spinal derangement, disk disease, peripheral neuropathies, tremor and rigidity History of leg/hip trauma, inflammation, infection rhabdomyolysis, or leg surgery in the past 3 months Have a diagnosis of osteoporosis (as determined by DXA) Participated in a resistance or aerobic training program in the last 3 months Engage in more than 1 hr/week of vigorous activity Body mass index >29 On hormone replacement therapy

Ages Eligible for Study
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Minimum Age: 65 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Screening
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Low 25(OH)D<br>We will recruit individuals with low 25(OH)D (<30ng/mL). | Other: 7 continuous days of aerobic training<br>* For 7 consecutive days, subjects will perform up to 45 minutes of exercise consisting of treadmill walking at a progressive intensity of about 60-65% of their maximum heart rate. This heart rate range is estimated to be below 60% VO2 max.<br>|
| Other: High 25(OH)D<br>We will recruit individuals with higher 25(OH)D (at least 20ng/mL units higher then that of the low 25(OH)D group). | Other: 7 continuous days of aerobic training<br>* For 7 consecutive days, subjects will perform up to 45 minutes of exercise consisting of treadmill walking at a progressive intensity of about 60-65% of their maximum heart rate. This heart rate range is estimated to be below 60% VO2 max.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Muscle VO2 consumption | The objective is to examine the difference in gastrocnemius VO2 consumption in individuals that either have normal-high or low 25(OH)D and are undergoing 7-days of a treadmill training program. | Up to 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Muscle Metabolic Function, Vitamin D Status, 25(OH)D, Older Adults