Safety Study of an Immune Response Modifier in Patients With Refractory Solid Organ Tumors

Study Overview
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Brief Summary
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Study 1493-852A is a phase 1 study with the primary objective of determining safety and the highest tolerated dose of an experimental immune response modifier administered intravenously to patients with solid organ tumors not responsive to currently available treatments. The secondary objective of the study is to monitor the tumor response to this form of treatment.

Official Title
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Phase I, Open Label Safety, Pharmacokinetic, and Pharmacodynamic Dose Escalation/De-escalation Study of 852A Administered Intravenously to Subjects With Refractory Solid Organ Tumors

Conditions
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Neoplasms

Intervention / Treatment
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* Drug: 852A


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Have solid organ tumors refractory to currently available treatments. Eastern Cooperative Oncology Group (ECOG) performance status less than or equal to 2 Have a life expectancy of 4 months Have normal organ and bone marrow function Exclusion Criteria: Have had biologic, hormonal, anti-neoplastic chemotherapy, or radiation therapy within 4 weeks prior to the 1st dose of the study drug or those who have not recovered from adverse events from agents administered more than 4 weeks earlier. Use of investigational agent in the 4 weeks prior to 1st dose of the study drug Use of immunosuppressive therapy in the 4 weeks prior to the 1st dose Have a history of, or clinical evidence of, myocardial ischemia, congestive heart failure, or myocardial arrhythmias requiring treatment within the past 6 months Have uncontrolled intercurrent or chronic illness, but not limited to, ongoing or active infection such as hepatitis B or C, immune dysfunction such as autoimmune disease, endocrine dysfunction such as hypo- or hyperthyroidism, psychiatric illness such as depression or suicidal tendency or social situations that would limit compliance with study requirements Have a history of disease requiring ongoing steroid treatment Have a history of seizure disorders uncontrolled on medication Have a history of clinically significant coagulation or bleeding disorders or abnormalities Are HIV positive. HIV positive subjects are excluded from the study because of possible interactions with the immunomodulatory effects of 852A and because of potential pharmacokinetic interactions associated with combination retroviral therapy. Are pregnant or lactating

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: 852A|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Safety and Pharmacokinetics |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Tumor Response |  |  | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Solid Organ Tumors