Characterisation of Occupational Allergy to Drosophila

Study Overview
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Brief Summary
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Allergy is a very common problem and can be a handicap in everyday life, specially when symptoms occur at work place. Some persons working with drosophila developed respiratory symptoms. Investigators tried to analyze if these manifestations could be due to a specific allergy to drosophila.

Detailed Description
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To do so, investigators invited laboratory workers who presented any symptoms in presence of drosophila to undergo skin prick tests in order to determine if a specific sensibilization to drosophila exists. Then, a blood sample is taken from these persons to research specific IgE directed against drosophila. By this way, investigators hope determine if a specific allergy to drosophila exists, its characteristics as prevalence, symptoms, populations concerned...in order to better protect laboratory workers and prevent allergy incidence.

Conditions
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Drosophila, Clinical Symptoms

Intervention / Treatment
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* Other: blood test (four dry tubes 7ml) and prick tests


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: major males or females (aged <68) who work in laboratory with drosophila in Montpellier (France) clinical symptoms in presence of drosophila The subject must be affiliated to a social security scheme Provision of informed consent prior to any study specific procedures Exclusion Criteria: The patient has indicated against (or incompatible drug combination) concerning the implementation of a prick test antihistamine cure in progress Inability to understand the nature and goals of the study and / or communication difficulties with the investigator No affiliation to a French social security recipient or not such a scheme Major protected by law (guardianship, curator or under judicial protection) deprivation of liberty by judicial or administrative decision Increased likelihood of non compliance to the protocol or abandonment under study pregnancy or breastfeeding

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 68 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: laboratory workers with symptoms in presence of drosophila<br> | Other: blood test (four dry tubes 7ml) and prick tests<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of participants with positive prick test to drosophila | Prick tests : measuring the size of the skin reaction (wheal) after prick tests with drosophila. A wheal measuring more than 4 millimeters in diameter sign a sensitization to drosophila. Then, a blood sample is collected in order to measure specific drosophila IgE rate | The day of inclusion | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Survey to analyse risk factors for allergy to drosophila | analysis of professional (attended institute, time from start working with drosophila, type of animal manipulation (species, living, dead, DNA, protein) use of protection,) or personal factors (age, gender, others allergies, treatment used) which could lead to allergic reaction to drosophila | The day of inclusion |