Consolidation & Interference in Multiple Sclerosis

Study Overview
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Brief Summary
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The purpose of this research study is to investigate whether minimizing interference improves memory in multiple sclerosis.

Detailed Description
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The ability to form new long-lasting memories is important for successful independent living and a high quality of life. Roughly half of the individuals diagnosed with Multiple Sclerosis (MS) have difficulty remembering new information and this is likely associated with poor acquisition of new information. There are only a limited number of studies that have investigated memory consolidation in MS. The current study will investigate the role of interference during the consolidation time period of memory formation.

Official Title
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Consolidation & Interference in Multiple Sclerosis

Conditions
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Multiple Sclerosis

Intervention / Treatment
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* Behavioral: Interference onset


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: If you are between the ages of 18-65. If you have a diagnosis of Multiple Sclerosis (MS) or are medically healthy. If you have MS, you have not had a flare up of MS symptoms in the past month. You do not have other neurological issues such as, Epilepsy or Stroke. You do not have a significant history of psychiatric problems or a current diagnosis of Major Depressive Disorder, Schizophrenia, Bipolar Disorder . You do not have a significant history of drug or alcohol abuse. You can read and speak English fluently. You are not currently taking steroids. Exclusion Criteria: You are younger than 18 years old. You are older than 65 years old. You have had a prior stroke or neurological disease other than MS. You have a history of significant psychiatric illness (for example, bipolar disorder, schizophrenia, or psychosis) or a current diagnosis of Major Depressive Disorder, Bipolar Disorder. You have a significant alcohol or drug abuse history. You are currently taking steroids.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Unfilled interference<br>Interference onset: delayed test at 540000 ms | Behavioral: Interference onset<br>* Temporal duration of interference onset.<br>|
| Experimental: Early interference<br>Interference onset: delayed test at 0 ms | Behavioral: Interference onset<br>* Temporal duration of interference onset.<br>|
| Experimental: Mid interference<br>Interference onset: delayed test at 360000 ms | Behavioral: Interference onset<br>* Temporal duration of interference onset.<br>|
| Experimental: Late interference<br>Interference onset: delayed test at 180000 ms | Behavioral: Interference onset<br>* Temporal duration of interference onset.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Recall Proportion |  | 2 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Memory