LOC387715/HTRA1 Variants in Polypoidal Choroidal Vasculopathy in a Korean Population

Study Overview
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Brief Summary
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This study is to investigate whether variants in the LOC387715 locus and the HtrA serine peptidase 1 (HTRA1) gene within the 10q26 locus are associated with polypoidal choroidal vasculopathy and whether they are associated with clinical patterns including angiographic phenotype in a Korean population.

Detailed Description
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This is a cross-sectional case-control study. One hundred Korean patients with polypoidal choroidal vasculopathy and 100 control subjects were genotyped for the LOC387715 (rs10490924) and the HTRA1 gene polymorphism (rs11200638)

Official Title
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LOC387715/HTRA1 Variants in Polypoidal Choroidal Vasculopathy in a Korean Population

Conditions
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Age-Related Macular Degeneration

Intervention / Treatment
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* Genetic: LOC387715/HTRA1 genotyping


Participation Criteria
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Eligibility Criteria
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Polypoidal choroidal vasculopathy group Inclusion Criteria: patients older than 60 years of age at onset polyp-like terminal aneurysmal dilations with or without branching vascular networks in indocyanine green angiography and subretinal reddish-orange protrusions corresponding to polyp-like lesions Exclusion Criteria: eyes with pathologic myopia, angioid streaks, central serous chorioretinopathy, and other retinal or choroidal diseases Control group Inclusion Criteria: individuals without retinal diseases and without any signs of polypoidal choroidal vasculopathy or age-related macular degeneration on the bases of comprehensive ophthalmic examination results

Ages Eligible for Study
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Minimum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: polypoidal choroidal vasculopathy<br>patients with polypoidal choroidal vasculopathy | Genetic: LOC387715/HTRA1 genotyping<br>* Genomic DNA was extracted from whole blood by standard methods. Genotyping was performed using SNP Genotyping Assays.<br>* Other names: genotyping;|
| Active Comparator: control<br>control group with no polypoidal choroidal vasculopathy | Genetic: LOC387715/HTRA1 genotyping<br>* Genomic DNA was extracted from whole blood by standard methods. Genotyping was performed using SNP Genotyping Assays.<br>* Other names: genotyping;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Genotyping of LOC387715/HTRA1 of PCV and control groups | to investigate whether variants in the LOC387715 locus and the HtrA serine peptidase 1 (HTRA1) gene within the 10q26 locus are associated with polypoidal choroidal vasculopathy (PCV) | 4weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Indocyanine angiographic findings of polypoidal choroidal vasculopathy | The association of the risk allele of the LOC387715/HTRA1 and indocyanine angiographic characteristics of polypoidal choroidal vasculopathy including subretinal hemorrhage, pigment epithelial detachment, and serous retinal detachment. | 20 minutes | 
| Visual acuity using Snellen chart | To evaluate the association between visual acuity and genotype of polypoidal choroidal vasculopathy | 2 x 5 minutes |