Effect of Precise Grip Strength Training on PICC Catheter-Related Thrombosis in Cancer Patients

Study Overview
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Brief Summary
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In this study, color Doppler ultrasound diagnostic instrument and electronic grip device were used to determine the best grip strength of patients with tumor PICC catheterization, formulate precise and standardized grip strength training guidance for them, provide personalized functional exercise health education, and observe the impact of precise grip strength training guidance on Peripheral central venous catheter-associated thrombosis. To provide a reference for clinical prevention of Peripheral central venous catheter-associated thrombosis in the future.

Official Title
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Effect of Precise Grip Strength Training on PICC Catheter-Related Thrombosis in Cancer Patients

Conditions
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Lung Cancer, Stomach Cancer, Breast Cancer, Liver Cancer, Colon Cancer, Rectal Cancer

Intervention / Treatment
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* Behavioral: Precision grip training
* Behavioral: Use maximum strength grip training
* Behavioral: Health education on routine grip strength training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Cancer patients undergoing chemotherapy throughout their treatment in our hospital Patients with PICC implanted for the first time and maintained at our hospital; Age 18-60 years; Normal cognitive function; the clenching movement is barrier-free; The material and performance of PICC catheter are silicone three-way valve catheter; Catheter placement under the guidance of portable color Doppler ultrasound diagnostic instrument; Voluntarily participate and sign the informed consent form. Exclusion Criteria: Patients treated with combined radiotherapy; Patients with coagulation dysfunction; Patients who need to use anticoagulant drugs due to underlying diseases; Puncture times more than 1 time; The blood flow velocity of catheterization vessel in calm state was less than 4.78cm/s.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: The control group<br>Patients were routinely implanted with PICC and received routine health education. The content of health education included face-to-face language explanation of the whole process of catheter knowledge, issuing catheter maintenance manual, issuing ordinary grip ball and telling how to use it, and follow-up. | Behavioral: Health education on routine grip strength training<br>* Patients were routinely implanted with PICC and received routine health education. The content of health education included face-to-face language explanation of the whole process of catheter knowledge, issuing catheter maintenance manual, issuing ordinary grip ball and telling how to use it, and follow-up.<br>|
| Experimental: Experiment 1 set<br>Patients were routinely implanted with PICC, and the optimal duration-relaxation time of grip strength training was adopted on the basis of health education in the control group. | Behavioral: Use maximum strength grip training<br>* Patients were routinely implanted with PICC, and on the basis of health education in the control group, the best continuous-relaxation time, frequency and maximum grip strength of patients were used for grip strength training.<br>|
| Experimental: Experiment 2 set<br>On the basis of control group Determine the best grip strength On the basis of the control group, color Doppler ultrasound and electronic grip force were used to record the optimal grip strength of patients to achieve effective blood flow velocity before and 24 hours after PICC insertion. Design precise grip strength training guidance program On the basis of the control group, the patients were instructed to perform grip strength training according to the determined best grip strength and the best duration of clenching and relaxation time. | Behavioral: Precision grip training<br>* First determine patients for holding the ball movement should reach the effective blood flow velocity and best duration - relaxation, and USES the electronic grips and color doppler ultrasonic diagnostic apparatus, for individual patients to choose the best grip the efforts and training, to form the best grip the training plan, and observe the scheme for Peripheral central venous catheter-associated thrombosis prevention effect.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of Peripheral central venous catheter-associated thrombosis in patients with PICC tube | Before catheterization, 24 hours after catheterization, and weekly maintenance, color Doppler ultrasound diagnostic instrument was used to diagnose venous thrombosis (including asymptomatic thrombosis) and its classification. The patients were observed for 8 weeks. | 8 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hemodynamic changes of the patient | During weekly maintenance, color Doppler ultrasound was used to measure the blood velocity of the arm axillary vein on the side of the catheter, and the maximum blood velocity (Vmax, cm/s) was recorded. | 8 weeks | 
| Analysis of the influencing factors of Peripheral central venous catheter-associated thrombosis formation | By investigating the baseline data of patients, the related factors affecting the formation of PICC-CRT in patients with tumor tube in the baseline data of the same group were analyzed and compared. | 8 weeks | 
| Patients' satisfaction with health education after PICC catheterization | At the end of the intervention, the patients' attitude towards PICC catheterization health education questionnaire (self-made) was distributed to the study subjects, and the satisfaction of the study subjects with the health education after PICC catheterization was learned through the questionnaire. | 8 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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PICC；Cancer patients；Grip strength training