Acid Base Balance of ICU Patients With Severe Hypoalbuminemia, Before and After an Albumin Infusion, Using Stewart Approach

Study Overview
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Brief Summary
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The primary purpose was to describe the acid base balance of ICU patients with severe hypoalbuminemia using Stewart's approach for acid base disorders, before and after an human albumin perfusion.

Detailed Description
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Prospective study, for ICU patient with severe hypoalbuminemia < 20g/L, determining biological parameters from Stewart approach for acid base disorders (pH, SIDe, SIDa, SIG, Atot, PaCO2) before, and at 1hour, 2hours and 24 hours after a 200mL 20% human albumin perfusion (the consensus conference ANAES of 1995 recommands to correct hypoalbuminemia below 20g/L). Clinical parameters (respiratory, haemodynamic, neurologic) were also collected at the same times.

Official Title
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Acid Base Balance of ICU Patients With Severe Hypoalbuminemia, Before and After an Albumin Infusion, Using Stewart Approach

Conditions
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Hypoalbuminemia, Adult ICU Patient, Stewart Approach for Acid Base Disorders, Human Albumin Perfusion

Intervention / Treatment
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* Other: stewart approach


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: serum albuminemia < 20g/L adult ICU patient Arterial line Exclusion Criteria: albumin allergy pregnancy congestive heart failure

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| hypoalbuminemia<br>The primary purpose was to describe the acid base balance of ICU patients with severe hypoalbuminemia using Stewart's approach for acid base disorders, before and after an human albumin perfusion | Other: stewart approach<br>* Prospective study, for ICU patient with severe hypoalbuminemia < 20g/L, determining biological parameters from Stewart approach for acid base disorders (pH, SIDe, SIDa, SIG, Atot, PaCO2) before, and at 1hour, 2hours and 24 hours after a 200mL 20% human al Clinical parameters (respiratory, haemodynamic, neurologic) were also collected at the same times.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| changes in pH and independent pH determinants using Stewart approach |  | at 1 hour, 2 hours and 24 hours after a 200mL of 20% human albumin perfusion. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| changes in neurologic parameters |  | at 1 hour, 2 hours and 24 hours after a 200mL of 20% human albumin perfusion. | 
| changes in hemodynamic parameters |  | at 1 hour, 2 hours and 24 hours after a 200mL of 20% human albumin perfusion. | 
| changes in respiratory parameters |  | at 1 hour, 2 hours and 24 hours after a 200mL of 20% human albumin perfusion. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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hypoalbuminemia, -acid base balance, acid base disorders, critical ill, Stewart approach, human albumin infusion