Exercise for Elderly Lymphoma Patients

Study Overview
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Brief Summary
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This pilot study was designed in a real-life setting to establish the feasibility, the safety and the activity of a supervised and combined Exercise Training (ET) program in adult and elderly lymphoma patients undergoing cancer-treatments.

Detailed Description
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Eligible patients were assigned to the ET group. All the patients eligible for exercise but not partiticpating to the ET program because of logistical reasons, were considered as the control group. All clinical outcomes were assessed before exercise training (T0), 3 (T1) and 6-months (T2) after the beginning of the exercise.

Official Title
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Exercise Training is a Feasible and Active Complementary Therapy in Adult and Elderly Patients Receiving Anti- Lymphoma Treatments

Conditions
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Elderly Lymphoma Patients

Intervention / Treatment
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* Other: exercise training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ≥18-80 years old, histologically conﬁrmed HL or NHL, patients in need of first or subsequent lines of systemic treatment and with a long-life expectancy Exclusion Criteria: Patients were excluded if they had less than 4 months of anti-cancer treatment to be delivered, severe orthopaedic, cardiac, pulmonary, or cognitive impairment, osteolytic lesions with the risk of fracture, cachexia or if they were ≥ 65 years and frail on the basis of comprehensive geriatric assessment

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Exercise Training Group<br>Exercise training group performed three weekly sessions for 16 weeks. This program consisted of moderate intensity aerobic, resistance, balance, and stretching exercises. The duration of every exercise session was 35 minutes during the first week and 65 minutes from the second week onward. | Other: exercise training<br> <br> |
| No Intervention: Control Group<br>The control group received usual lymphoma care | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The eligibility rate | the eligibility rate was assessed by the number of eligible patients divided by the total number of elements on the sampling frame. | 6 months | 
| The recruitment rate | the recruitment rate was assessed by the number of patients included in the study divided by the total number of eligible patients | 6 months | 
| The exercise adherence rate | The exercise adherence rate was assessed by the number of exercise sessions attended out of the 48 sessions scheduled for each patient | 4 months | 
| The assessment rate | The assessment rate was assessed by the number of patients who completed the T1 and T2 follow-up times over the total number who participated in the study | 6 months | 
| Safety of the exercise training | Safety was assessed by monitoring any serious adverse events that occured during the ET period. | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Exercise training, Complementary therapy