Evaluation of Antioxidant and Anti-inflammatory Effect of Matcha Tea Intake on Periodontal Health

Study Overview
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Brief Summary
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Aim of the study: This study aims to evaluate the antioxidant and beneficial effects of matcha tea daily intake on periodontal health. Objectives: To evaluate the salivary level of antioxidants (catalase, total antioxidant capacity) after matcha tea intake compared to green tea over a period of one month. To evaluate the clinical periodontal parameters including bleeding on probing (BOP), probing pocket depth (PPD) and plaque index (PI) after matcha tea intake compared to green tea over a period of one month. To evaluate the salivary levels of IL-1B after matcha tea intake compared to green tea over a period of one month.

Official Title
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Evaluation of Antioxidant and Anti-inflammatory Effect of Matcha Tea Intake on Periodontal Health

Conditions
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Gingival Disease

Intervention / Treatment
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* Dietary Supplement: green tea
* Dietary Supplement: matcha tea


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: • having at least 20 teeth, underwent no medical treatment during the last 3 months before examination and sampling, non-smoker, no history of systemic disease, gingivitis patient (having >10% bleeding sites with no PPD >3 mm). Exclusion Criteria: • wore orthodontic appliances, pregnant or currently in the breast-feeding period, periodontitis patient, smoker, has a history of systemic disease.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: green tea group<br>Mahmood Green Tea Sri Lanka. It will be given 2 cups / day for 30 days. | Dietary Supplement: green tea<br>* It will be given 2 cups / day for 30 days. To prepare each cup, a tea pack will be immersed into a cup of hot water.<br>|
| Experimental: matcha tea group<br>Jade Leaf Organic Japanese Matcha, USA. It will be given 2 cups / day for 30 days. | Dietary Supplement: matcha tea<br>* It will be given 2 cups / day for 30 days. To prepare each cup, a tea pack will be immersed into a cup of hot water.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change in salivary level of antioxidant marker | change in level of catalase enzyme in ku/L | 30 Days (baseline to one moth of tea intake) | 
| change in salivary level of ant-inflammatory marker | change in level of interleukin- one beta (IL-1B) in pg/L | 30 Days (baseline to one moth of tea intake) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change in percentage of bleeding on probing (BOP) | change in BOP percentage. less percentage means less inflammation in gingival tissue | 30 Days (baseline to one moth of tea intake) | 
| change in plaque index (PI) scores | change in PI scores. less scores mean less dental plaque accumulated onto teeth surfaces | 30 Days (baseline to one moth of tea intake) |