Effect of the Salbutamol on Mechanical Properties of Respiratory System

Study Overview
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Brief Summary
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The aim of this study is to assess the bronchodilator response of salbutamol on respiratory mechanics of healthy individuals, smokers and COPD with varying degrees of airway obstruction.

Detailed Description
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Clinical evaluation will be conducted and anthropometric measurements, then the pulmonary function tests: forced oscillation technique (FOT), whole body plethysmography, spirometry and-administration of salbutamol aerosol for assessment of bronchodilator response. After 20 minutes, the individual will be evaluated again following the same sequence.

Official Title
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Effect of the Use of Salbutamol on the Mechanical Properties of the Respiratory System of Healthy Individuals, Smokers and COPD Patients

Conditions
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Smoking, Airway Obstruction

Intervention / Treatment
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* Drug: Salbutamol sulphate


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: healthy individuals, smokers and patients with chronic obstructive pulmonary disease. Exclusion Criteria: healthy subjects: no history of smoking respiratory infection and disease respiratory smokers and chronic obstructive pulmonary disease patients: asthma and other respiratory diseases.

Ages Eligible for Study
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Minimum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Salbutamol<br>Short-acting bronchodilator for use in humans released by the Ministry of Health, widely used worldwide for the treatment of chronic obstructive pulmonary disease. | Drug: Salbutamol sulphate<br>* bronchodilator test, beta2-agonist, short-acting, six hours duration, 400 micrograms.<br>* Other names: LOTE: YR1070;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Respiratory function test | Evaluation of pulmonary mechanics before and after salbutamol (short-acting bronchodilator) in healthy individuals, smokers and chronic obstructive pulmonary disease in stages: mild, moderate, severe and very severe according to GOLD criteria. | two o'clock | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Salbutamol | In the bronchodilator test will be used 400 micrograms of beta2-agonist short-acting. They will be asked to exhale slowly until they can no longer expel more air from the lungs. To place the inhaler with a spacer between the lips, pressing them well, but no bite. Shortly thereafter start to breathe through the mouth and will be released a jet of 100 micrograms of the bronchodilator. Then they will hold their breath for 10 seconds. 3 puffs are made with 1 minute interval between each application. | twenty minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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chronic obstructive pulmonary disease,, bronchial reversibility,, bronchodilator,, respiratory impedance,, forced oscillation technique,, plethysmography,, spirometry, Diagnostic Techniques, Respiratory System