The Prognostic Significance of Premature Ventricular Complexes in Patients Without Structural Heart Disease

Study Overview
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Brief Summary
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With this project the investigators aim to investigate whether premature ventricular complexes (PVC) have a prognostic significance in persons without structural heart disease. Further the investigators look at the possible connection between PVC-morphology and clinical outcome and investigate whether advanced cardiac imaging-methods may identify subtle signs of heart disease in PVC-patients with normal findings at echocardiography.

Detailed Description
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The PULSE project consists of four different studies: in study one the investigators include patients who are evaluated because of PVCs and have no signs of structural heart disease at echocardiography and exercise test. The investigators follow them (average follow-up time 3,5 years) to investigate if they have a higher mortality och cardiovascular morbidity than standard population in study two the investigators carry out a sub-group analysis of the population in study one to assess whether PVC:s different sites of origin (morphology) are related to the clinical outcome in study three the investigators include persons with a high PVC-burden (at least 10 000 PVC:s/day) and normal echocardiography. The included subjects undergo magnetic resonance (MR) to investigate whether it can identify signs of heart disease where standard echocardiography cannot

Official Title
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The Prognostic Significance of Premature Ventricular Complexes in Patients Without Structural Heart Disease

Conditions
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Premature Ventricular Complexes Multiple, Premature Ventricular Contraction

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: - Diagnosed with Premature Ventricular Complexes at Three major Hospitals in Stockholm, Sweden Exclusion Criteria: History of Myocardial Infarction Undergone coronary arterty bypass grafting (CABG) Finding of Heart Failure at echocardiography Direct or indirect findings of coronary ischaemia at exercise test, coronary angiography or other equivalent examination

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality | Mortality compared with sex and age-matched control population. Data for Control population obtained via Socialstyrelsen (The Swedish Health Board) | Average follow-up time 3,5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cardiovascular morbidity | Incidence of heart failure and myocardial infarction in the study population compared with age and sex-matched Controls. Control data obtained via Socialstyrelsen (The Swedish Health Board) | Average follow-up time 3,5 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Premature, Ventricular, Complexes, Beats, Prognosis