Hyperuricemia and Left Ventricular Diastolic Function

Study Overview
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Brief Summary
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Metabolic syndrome and hyperuricemia were both associated with inflammation, leading to diversities of cardiovascular disease such as left ventricular diastolic dysfunction, but the relationship among these entities remained unclear. The aim of the present study focuses on the association among hyperuricemia, diastolic dysfunction and inflammatory biomarkers in apparently healthy individuals with metabolic syndrome

Detailed Description
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Apparently healthy individuals with metabolic syndrome were prospectively and consecutively enrolled since August 2017. Blood samples were obtained after participants are fasting for at least 12 hours, including serum uric acid, high-sensitivity C-reactive protein, high-sensitivity interleukin-6, tumor necrotizing factor alpha, fasting glucose, glycosylated hemoglobin, insulin, lipid profile, creatinine, alanine aminotransferase, sodium, potassium, and calcium. All echocardiographic parameters were measured in accordance with the American Society of Echocardiography guidelines.

Official Title
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Associations and Plausibility Among Left Ventricle Diastolic Function, Serum Uric Acid and Inflammatory Biomarkers in Individuals With Cardiometabolic Risks - A Prospective Observational Study

Conditions
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Hyperuricemia, Metabolic Syndrome, Left Ventricular Diastolic Dysfunction

Intervention / Treatment
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* Diagnostic Test: hyperuricemia


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age between 20 to 75 years Metabolic syndrome Exclusion Criteria: Left ventricular ejection fraction <40% Severe valvular heart disease Significant structure heart diseases such as hypertrophic, dilated, infiltrative or restrictive cardiomyopathy, or congenital heart disease Persistent or chronic atrial fibrillation Status post cardiac surgery, including coronary artery bypass surgery of valve intervention Status post intra-cardiac device implantation Chronic obstructive pulmonary disease Severe anemia An obvious systemic disease that interferes left ventricular diastolic dysfunction such as acute coronary syndrome

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Normouricemia<br>Serum uric of 7mg/dl or less in men or 6mg/dl or less in women | Diagnostic Test: hyperuricemia<br>* serum uric acid of 7mg/dl or more in men or 6mg/dl or more in women<br>|
| Hyperuricemia<br>Serum uric of 7mg/dl or more in men or 6mg/dl or more in women | Diagnostic Test: hyperuricemia<br>* serum uric acid of 7mg/dl or more in men or 6mg/dl or more in women<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Left ventricle diastolic dysfunction with elevated left atrial pressure | The contemporary definition of left ventricular diastolic dysfunction with elevated left atrial pressure is mainly >50% positive of the following criteria: (1) average E/e' ≥14 (2) left atrial volume index >34 ml/m2 (3) tricuspid regurgitation velocity >2.8 m/s | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| high-sensitivity C-reactive protein | determined by Latex enhanced immunoturbidimetric，ADVIA 1800，ADVIA Chemistry XPT，Dimension RXL，SIEMENS，AU 640，Beckman Coulter | 1 week | 
| high-sensitivity interleukin-6 | determined by elisa enzyme-linked immunosorbent assay, R & D system | 1 month | 
| tumor necrotizing factor alpha | determined by elisa enzyme-linked immunosorbent assay | 1 month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Hyperuricemia, Metabolic syndrome, Left ventricular diastolic dysfunction, Inflammation