Measuring Cortisol Levels in Persons With Parkinson's (PD)

Study Overview
=================
Brief Summary
-----------------
The objective of this study is to evaluate the cortisol awakening response with persons with Parkinsons Disease (PD), Huntingtons Disease (HD), and controls. These data are desired so experience can be gained with measuring stress levels subjectively and objectively in persons with PD, HD, and controls.

Detailed Description
-----------------
Telephone consent will be obtained. Participants will collect saliva at twelve time points - four times a day for three days. Visits will be conducted virtually (over the internet). The virtual visit is to assess Parkinson's or Huntington's disease status, stress, mood, and quality of life.

Official Title
-----------------
Measuring Cortisol Levels in Persons With Parkinson's (PD)

Conditions
-----------------
Parkinson Disease, Huntington Disease

Intervention / Treatment
-----------------
* Other: No Intervention - Observational Study


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Group (3) Inclusion: No significant neurological disorder PSS score of greater than or equal to 13. Group (5) Inclusion: HD diagnosis or HD gene carrier a Perceived Stress Scale (PSS) score higher than or equal to 13. Group (6) Inclusion: HD diagnosis or HD gene carrier PSS score lower than 13 Group (7) Inclusion: PD diagnosis Prior completion of the study. Exclusion Criteria: The use of medications known to effect cortisol levels (estrogen, synthetic glucocorticoids, androgens, phenytoin, spironolactone, prednisone, prednisolone, and hydrocortisone).

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 99 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Parkinson's - High Stress *FULL NOT RECRUITING<br>Parkinson's disease patients with self-reported high strain/stress. | Other: No Intervention - Observational Study<br>* No Intervention - Observational Study<br>|
| Parkinson's - Low Stress *FULL NOT RECRUITING<br>Parkinson's disease patients with self-reported low strain/stress. | Other: No Intervention - Observational Study<br>* No Intervention - Observational Study<br>|
| Controls - High Stress *FULL NOT RECRUITING<br>Healthy controls (no neurological disease) with self-reported high strain/stress. | Other: No Intervention - Observational Study<br>* No Intervention - Observational Study<br>|
| Controls - Low Stress *FULL NOT RECRUITING<br>Healthy controls (no neurological disease) with self-reported low strain/stress. | Other: No Intervention - Observational Study<br>* No Intervention - Observational Study<br>|
| Huntington's - High Stress *FULL NOT RECRUITING<br>Huntington's disease patients and/or Huntington's disease gene carriers with self-reported high strain/stress. | Other: No Intervention - Observational Study<br>* No Intervention - Observational Study<br>|
| Huntington's - Low Stress *FULL NOT RECRUITING<br>Huntington's disease patients and/or Huntington's disease gene carriers with self-reported low strain/stress. | Other: No Intervention - Observational Study<br>* No Intervention - Observational Study<br>|
| Parkinson's Disease - ReEnrollment (COVID-19) *FULL NOT RECRUITING<br>Parkinson's disease patients that had previously completed the study. | Other: No Intervention - Observational Study<br>* No Intervention - Observational Study<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Awakening Salivary Cortisol level (ug/dL) Response | Salivary Cortisol level (ug/dL) Response is the change in cortisol between awakening and 30 minutes after awakening. | Collected upon awakening and 30 minutes after awakening | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Movement disorders, Metabolic Stress, Basal Ganglia Disorders