International Bifurcation Study

Study Overview
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Brief Summary
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The IBS registry is an observational, multi-center, real-world registry of stenting in coronary bifurcation lesions that will collect information on procedures and outcomes from various participating centers. The aim of this registry is to investigate long-term clinical results and predictors of adverse outcomes after PCI for coronary bifurcation lesions among various participating centers.

Detailed Description
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Patients with coronary bifurcation lesions, if they meets all the study inclusion criteria and none of the exclusion criteria, after signing the informed consent, they will underwent PCI according to the current standard of care and will be entered in the registry. Follow-up for all subjects will continue for 5 years.

Official Title
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International Prospective Register on Treatment of Coronary Artery Bifurcation Lesions

Conditions
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Coronary Bifurcation Lesion

Intervention / Treatment
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* Procedure: PCI of bifurcation lesions


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age ≥ 18 years Any type of bifurcation lesion in major epicardial artery Exclusion Criteria: Patient refused informed consent to participate in the registry

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 100 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| PCI of bifurcation lesions<br>Patients who have undergone bifurcation coronary artery stenting. | Procedure: PCI of bifurcation lesions<br>* Different approaches for treatment of bifurcation coronary artery disease.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Procedural success | Achievement of technical success and with no in-hospital major adverse cardiac events | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Major Adverse Cardiac and Cerebrovascular Events | Death, myocardial infarction (MI), target vessel revascularization (TVR), or stroke. | 6 months, 1 year, 3 years, 5 years | 
| All cause mortality | All of the deaths that occur in a study group, regardless of the cause. | 6 months, 1 year, 3 years, 5 years | 
| Death from cardiac causes | All deaths will be assumed cardiovascular in nature unless a non-cardiovascular cause can be clearly provided (e.g. malignancy, trauma, and infection). | 6 months, 1 year, 3 years, 5 years | 
| Myocardial infarction | The presence of electrocardiography findings indicative of ischemia that were not related to the index procedure, as well as chest discomfort associated with creatinine kinase-myocardial band fraction or troponin-T/troponin I greater than the upper limit of normal. | 6 months, 1 year, 3 years, 5 years | 
| Target vessel revascularization | Repeat PCI of the lesion within 5 mm of stent deployment or bypass graft surgery of the target vessel. | 6 months, 1 year, 3 years, 5 years | 
| Stent thrombosis | Sudden occlusion of a stented coronary artery due to formation of thrombosis.According to the Academic Research Consortium was defined as definite, probable, or possible. | 6 months, 1 year, 3 years, 5 years |