Cognitive Status After Removal of Skull Base Meningioma

Study Overview
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Brief Summary
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The purpose of this prospectively enrolling trial is to assess long-term cognitive outcomes of patients undergoing surgery for resection of a meningioma associated with the frontal and temporal lobes.

Detailed Description
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This study will look at patients who are undergoing resection of a skull based meningioma, located in the frontal or temporal lobe, via craniotomy or via endoscopic endonasal approach. The study will compare cognitive function at baseline, at six weeks postoperatively and at one year postoperatively. The cognitive testing being done at baseline will be a clinical care set of assessments done by the speech language pathology team and will include the RBANS tests, the MoCA, PROMIS-29, and NeuroQOL-Cognitive Functions.

Official Title
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Pre and Post-Operative Cognitive Status in Patients Undergoing Surgery for Resection of Meningioma Associated With the Frontal and Temporal Lobes

Conditions
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Meningioma, Skull Base Meningioma, Frontal Meningioma, Temporal Meningioma, Cognitive Impairment, Cognitive Decline, Post-Surgical Cognition

Intervention / Treatment
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* Other: Long-term Cognitive testing


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Subject has a meningioma associated with the frontal or temporal lobes Subject is scheduled to undergo open craniotomy or Endoscopic Endonasal surgery Subject is 18 years of age or older The subject must in the investigator's opinion, be psychosocially, mentally, and physically able to fully comply with this protocol including the required follow-up visits, the filling out of required forms, and have the ability to understand and give written informed consent Previous surgery will not exclude the patient as a new baseline cognitive evaluation will occur. Exclusion Criteria: Patient is a prisoner Patient is 90 years of age or older Pregnant women Previous radiation to the brain

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 89 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Meningioma Group<br>This group will include all patients in the study, regardless of location (frontal or temporal lobe) or surgical approach (endoscopic endonasal or craniotomy). Fifty patients will be included in the cohort | Other: Long-term Cognitive testing<br>* These patients will undergo their standard of care cognitive testing at baseline, six weeks post-operatively and one year post-operatively.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overall cognitive function | Cognitive function will be compared at baseline and at one year post-operatively. | 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cognitive function based on surgical approach using Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) | Patients divided by approach and overall cognitive function will be evaluated. | 12 months | 
| Cognitive function based on tumor location using Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) | Patients will be divided by tumor location and cognitive function will be evaluated. | 12 months |