Comparison of Physical Activity Level Between Patients With Bronchiectasis and Healthy Subjects

Study Overview
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Brief Summary
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The purpose of this study is to compare physical activity levels between patients with bronchiectasis and healthy subjects. We hypothesize that patients with bronchiectasis will have lower levels of physical activity, since physical activity levels is affected by reduced exercise tolerance, severity of disease and other disease related symptoms and conditions.

Detailed Description
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Physical activity limitation in chronic respiratory diseases is caused by many factors including respiratory, hemodynamic, and peripheral muscle weakness. Bronchiectasis is characterized by irreversible widening of the medium-sized airways, with inflammation, chronic bacterial infection and destruction of the bronchial walls. In addition to pulmonary function worsening, extra pulmonary features such as reduced peripheral muscle endurance can be a significant physical problem which causing a decrease in physical activity levels. Despite physical activity is considered to be essential for the management of chronic respiratory diseases, there is a lack of scientific study, which compares physical activity levels between patients with bronchiectasis and healthy subjects. This study will assess physical activity level, exercise capacity, quality of life and peripheral muscle strength in patients with bronchiectasis compared to healthy subjects.

Official Title
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Comparison of Physical Activity Level Between Patients With Bronchiectasis and Healthy Subjects

Conditions
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Bronchiectasis

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Inclusion criteria of the Bronchiectasis Group: Diagnosis of bronchiectasis Being 18 years of age or older Able and willing to complete the informed consent process. Able to walk and co-operate Exclusion Criteria: Exclusion criteria of Bronchiectasis Group: Unstable medical condition To have severe neurological, orthopedic problems or severe heart failure. The control group will consist of healthy subjects.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of steps on accelerometer | Participants will wear an accelerometer (physical activity monitor) for seven consecutive days. | Seven days | 
| Energy expenditure on activity monitor | Total energy expenditure will be calculated using activity monitor for seven consecutive days | Seven days | 
| Exercise capacity using 6-minute walk test and incremental shuttle walk test | 6-minute walk test will be performed in a long, straight, enclosed corridor 30 meters in length. Patients are required to walk in their walking speed with standardized instructions. The distance walked by subjects during 6 minutes will be recorded. The incremental shuttle walk test will be performed in an enclosed corridor. Patients are required to walk back and forth, turning around two cones placed 9 meters apart making the shuttle distance 10 meters long. Patients will follow the rhythm dictated by the audio signal. | 8th day (after using device) | 
| Physical activity level using International Physical Activity Questionnaire | Instrument to obtain internationally comparable data on health related physical activity This measure assesses the types of intensity of physical activity and sitting time in daily life and estimates total physical activity in MET-min/week and time spent sitting. It comprises open-ended questions surrounding individuals' last 7-day recall of physical activity. | 8th day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Shortness of breath using the Modified Medical Research Council Dyspnea Scale | Scale is used to establish functional impairment due to dyspnea attributable to respiratory disease. The scoring ranges from 0 to 4. The higher scores indicate higher perception of dyspnea. | 1st day (before using device) | 
| Quality of Life using St. George Respiratory Questionnaire | It measures the health impairment. The questionnaire consist of 50 items, 2 parts (3 components). The name of categories/domains were stated as follows: Part 1: Symptoms component (frequency&severity), Part 2: Activities that cause or are limited by breathlessness; Impact components (social functioning, psychological disturbances resulting from airways disease). The scores range from 0 to 100, with higher scores indicating more limitations. | 1st day | 
| Peripheral muscle strength test using a hand-held dynamometer | Measurement of peripheral muscle strength | 8th day (after using device) | 
| Maximal inspiratory and expiratory pressures measurement using a mouthpiece device | Measurement of respiratory muscle strength | 8th day (after using device) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Physical activity levels, Bronchiectasis