Lifestyle Modification and Potato Consumption

Study Overview
=================
Brief Summary
-----------------
The investigators hypothesize that consumption of potatoes is a healthy adjunct to lifestyle intervention in overweight and obese glucose intolerant adults. We will evaluate the effects of the consumption of potatoes (high or low resistant starch) vs. commonly consumed carbohydrate sources on glucose tolerance; and ( the extent to which potato consumption alters markers of lipid metabolism and inflammation in the context of a lifestyle intervention program.

Detailed Description
-----------------
Our primary objective is to compare the effects of potato consumption to those of commonly consumed carbohydrate sources on glucose tolerance and other cardiometabolic risk factors in overweight and obese, glucose intolerant men and women participating in a lifestyle intervention program. We hypothesize that consumption of potatoes is a healthy adjunct to lifestyle intervention in overweight and obese glucose intolerant adults. Our specific aims include: (1) to evaluate of the effects of the consumption of potatoes (high or low resistant starch) vs. commonly consumed carbohydrate sources on glucose tolerance; and (2) to determine the extent to which potato consumption alters markers of lipid metabolism and inflammation in the context of a lifestyle intervention program.

Official Title
-----------------
Lifestyle Modification and Potato Consumption

Conditions
-----------------
Obesity

Intervention / Treatment
-----------------
* Other: potatoes
* Other: other carbohydrate


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Men and women between 20-65 years of age. Overweight or obese (BMI 25 - 39.9 Kg/m2) Impaired Glucose Tolerance: fasting glucose between 100-125 mg/dL Willingness to comply with the demands of the experimental protocol Sedentary lifestyle Exclusion Criteria Major medical condition Smokers Unable to perform moderate exercise Use of medications that alter glucose or lipid metabolism Pregnant or lactating

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: High Resistant Starch Potatoes<br>Subjects will receive 1 serving daily for 8 weeks during the weight loss group sessions. | Other: potatoes<br>* Daily intake of assigned treatment for 8 weeks<br>|
| Experimental: Low Resistant Starch Potatoes<br>Subjects will receive 1 serving daily for 8 weeks during the weight loss group sessions. | Other: potatoes<br>* Daily intake of assigned treatment for 8 weeks<br>|
| Placebo Comparator: Other Carbohydrate Source<br>Subjects will receive 1 serving daily for 8 weeks during the weight loss group sessions. | Other: other carbohydrate<br>* Daily intake of assigned treatment for 8 weeks<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Glucose Tolerance |  | Days 0, 14, 28, 42, 56 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Weight Loss |  | Days 0, 14, 28, 42, 56 | 
| Functional Fitness |  | Days 0 and 57 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
resistant starch, lifestyle intervention