Measuring the Electrical Properties of Malignant Tissues Ex Vivo

Study Overview
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Brief Summary
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Previously published studies have indicated that there exist difference in electrical properties (EPs), i.e., the conductivity and relative permittivity, between malignant and adjacent normal tissue, which will be useful in the early detection of cancers. While the EP informations of cancer tissues are not sufficient enough. The purpose of this study is to measure the electrical properties of the excised malignant tissues obtained from cancer surgeries.

Detailed Description
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The measurements were conducted in the operating rooms of the hospital where the tissues were excised. Once the tissue was excised from the patient, the pathologist assisted the one of the engineers (already at the hospital) responsible to conduct the measurement. The specimen were designed to permit at least one measurement of malignant tissue and at least one measurement of normal tissue. Occasionally, the measurement of normal tissue was not possible if, for example, the normal tissue occupied a volume of small proportion for every excised specimen. The specimens for dielectric properties measurement were classified as normal or malignant by the pathologist based on his own expertise and decision criteria (visual inspection, anatomy) and the per-operative histological examination. The measurements were directly performed on the bulk specimen. The patient age, tissue temperature at the time of measurement and time between excision and measurement for each sample were recorded.

Official Title
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Measuring the Electrical Properties of the Excised Malignant Tissues Obtained From Cancer Surgeries

Conditions
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Neoplasms

Intervention / Treatment
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* Device: network analyzer


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Clinical diagnosis of cancer Disease Exclusion Criteria: None
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: network analyzer|The dielectric properties of the tissues were measured using the open-ended coaxial line method. The measurement system consisted of a network analyzer (Model 4395A, Agilent Corp., Santa Clara, CA) associated with an S-parameter test set (Model 87511A, Agilent Corp., Santa Clara, CA). A semi-rigid coaxial line with a diameter of 3.58 mm was connected to the network analyzer system by using a Bayonet Neill-Concelman connector. The other tip of the coaxial line (probe) was placed on the flat bare surface of the tissue that placed on a measurements experiment platform.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Conductivity of Malignant Tissues Measured Ex Vivo |  | one year | 
| Relative Permittivity of Malignant Tissues Measured Ex Vivo |  | one year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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electrical properties, malignant tissues, ex vivo