Stress Echocardiography in Patients Recovery From Mild COVID-19 Illness

Study Overview
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Brief Summary
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With the appearance of the new SARS-COV2 virus, additional challenges are being imposed on the medical community after the resolution of acute COVID-19 illness, resulting in specific pathophysiologic mechanisms that while acutely damage the lung parenchyma might chronically impact the cardiopulmonary system. This study aims to investigate changes after mild COVID-19 illness in echocardiographic indices at rest and stress.

Official Title
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Stress Echocardiography in Patients Recovery From Mild COVID-19 Illness

Conditions
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Echocardiography, Stress, COVID-19, Hypertension, Pulmonary

Intervention / Treatment
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* Diagnostic Test: echocardiogram 2D


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Having suffered mild COVID-19 illness PCR test negative after COVID-19 illness Men or women Age ≥18 years and < 45. No history of other cardiovascular or lung disease. No cardiovascular risk factors, that is, arterial systemic hypertension, smoking, diabetes, dyslipidemia No ongoing or previous cardio or vasoactive treatment Able to use the semi-supine exercise bicycle Able to give informed consent Exclusion Criteria: Poor acoustic window. Tricuspid regurgitation more than mild Professional sports activity Pregnancy Obesity (body mass index [BMI], ≥30 kg/m2). Inability to provide consent

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: echocardiogram 2D|The patient is accelerating against a workload that gradually increases at a constant rate during the exercise, images will be obtained by echocardiography. The patient begins with 25 Watts with increments of 25 Watts every 3 minutes, continuing the exercise until significant electrocardiographic changes occur or the patient starts with symptoms.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| • LA volume index | Left atrium volume index | 3 minutes | 
| • LV telediastolic diameter | Left ventricle telediastolic diameter | 3 minutes | 
| • LV telesystolic diameter | Left ventricle telesystolic diameter | 3 minutes | 
| • LV posterior wall | Left ventricle posterior wall | 3 minutes | 
| • RA area | Right atrium area | 3 minutes | 
| • RV basal dimensión | Right ventricle basal dimensión | 3 minutes | 
| • RV mid cavity dimension; | Right ventricle cavity dimensión | 3 minutes | 
| • RV longitudinal dimension | Right ventricle longitudinal dimension | 3 minutes | 
| • Distal, RV outflow tract dimension at the distal or pulmonic valve level | Distal, right ventricle outflow tract dimension at the distal or pulmonic valve level | 3 minutes | 
| • Proximal RV outflow tract dimension at the proximal subvalvular level | Proximal right ventricle outflow tract dimension at the proximal subvalvular level | 3 minutes | 
| • TAPSE | • Tricuspid annular plane systolic excursion | 3 minutes | 
| • RV free Wall strain | Right ventricle free Wall strain | 3 minutes | 
| • Inferior cava vein PW Doppler | Inferior cava vein PW Doppler | 3 minutes | 
| • E wave mitral | E wave mitral | 3 minutes | 
| • A wave mitral | A wave mitral | 3 minutes | 
| • E wave /A wave mitral | E wave /A wave mitral | 3 minutes | 
| • E-wave at mitral annulus | E-wave at mitral annulus | 3 minutes | 
| • E-wave at mitral annulus / A-wave at the mitral annulus | E-wave at mitral annulus / A-wave at the mitral annulus | 3 minutes | 
| • E wave/ E-wave at the mitral annulus | E wave/ E-wave at the mitral annulus | 3 minutes | 
| • E tricuspid (E) | E tricuspid (E) | 3 minutes | 
| • A tricuspid (A) | A triuspid (A) | 3 minutes | 
| • E/A | E/A | 3 minutes | 
| • Systolic pulmonary artery pressure | Systolic pulmonary artery pressure | 3 minutes | 
| • E-wave at the tricuspid annulus | E-wave at the tricuspid annulus | 3 minutes | 
| • Mean pulmonary artery pressure | Mean pulmonary artery pressure | 3 minutes | 
| • Stroke volume | Stroke volume | 3 minutes | 
| • Cardiac output | Cardiac output | 3 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Echocardiography, Stress, COVID-19, Pulmonary Hypertension