Trans-parenchymal Compressing Suture in Major Liver Resection

Study Overview
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Brief Summary
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Non-anatomical liver resection with appropriate resection margin was regarded as a potential curative treatment for selected major hepatic carcinoma due to preserving maximal normal liver, especially in cirrhotic patients. But occurrence of cutting surface related complications become a main challenge.

Detailed Description
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In order to better manage the cutting surface after liver resection, we further applied trans-parenchymal compressing suture to not good cutting surface in hope of decreasing cutting surface related complication. A majority of studies investigating cutting surface management are limited to non-surgical treatments, such as the application of hemostasis agents including fibrin sealants, oxidized cellulose, and absorbable gelatin sponge13-15 . But there is no consensus regarding the necessity of the hemostatic agent application to the liver cutting surface. Up to date, few studies investigate surgical suture management of the cutting surface in liver resection.

Official Title
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Application of Trans-parenchymal Compressing Suture in Major Liver Resection to Decrease Cutting Surface Related Complication.

Conditions
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Liver Carcinoma Resectable

Intervention / Treatment
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* Procedure: TCS


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: tumor size more than 5cm non-anatomical liver resection; Exclusion Criteria: intravascular infiltration with tumor embolus; previous liver surgical treatment (e.g. microwave ablation; preoperative transcatheter arterial chemoembolization (TACE); other concomitant extrahepatic procedures (e.g. splenectomy). exposed Glisson Shealth, main hepatic veins or (and) retro-hepatic inferior vena cava.
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Trans-parenchymal compressing suture<br>TCS: After liver transection, check for active hemorrhage and visible sites of bile leakage of cutting surface by stainless gauze which covered up on the raw cutting surface for 5 minutes. For patients with any positive findings including bloodstain and (or) bile staining, the cutting surface was recognized as not good cutting surface and further trans-parenchymal compressing sutured, if possible, using a hepatic needle. | Procedure: TCS<br>* The cutting surface recognized as not good cutting surface was further trans-parenchymal compressing sutured, if possible, using a hepatic needle.<br>* Other names: trans-parenchymal compressing suture;|
| No Intervention: Exposed surface (ES)<br>147 Patients with exposed surface (ES) were matched as control group. No TCS. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cutting surface related complications | After liver resection, some complication related cutting surface may occur, including surgery site infection, bile leakage, bleeding. | 90 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Interventions for cutting surface related complications | Once the cutting surface related complications occur, some interventions need to be performed to treat these complications, such as percutaneous abdominal paracentesis or reoperation. | 90 days |