A Novel Myocardial Impedance Mapping System for Ablation of Post-infarction Ventricular Arrhytmias in Humans

Study Overview
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Brief Summary
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Precise identification of the infarct scar is essential for successful catheter ablation of ventricular arrhythmias in patients with chronic myocardial infarction. Voltage mapping of endocardial electrograms is currently used to delineate the necrotic scar but this is influenced by the direction of the activation wave front and is not sensitive enough to differentiate distinct degrees of transmural injury in the scar. Mapping of local myocardial electrical impedance may overcome these limitations.

Detailed Description
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Clinical series: Patients with chronic infarction undergoing catheter ablation of ventricular arrhythmias will be submitted to mapping of both voltage and tissue impedance. Likewise, the accuracy of the two maps identifying the extent and transmurality of the infarction will be assesssed by gadolinium imaging. The impedance system is already constructed and certified for clinical research use.

Official Title
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A Novel Myocardial Impedance Mapping System for Ablation of Post-infarction Ventricular Arrhytmias in Humans

Conditions
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Ventricular Arrythmia, Infarction, Myocardial

Intervention / Treatment
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* Device: CardioZ multifrequency impedance recording system


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: More than 18 yearts Chronic myocardial infarction Undergoing ventricular ablation of ventricular arrhythmias Exclusion Criteria: patients with device not suitable for cardiac magnetic ressonance (CMR) pregnacy

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| CASE GROUP<br>patients with chronic infarction undergoing catheter ablation of ventricular arrhythmias | Device: CardioZ multifrequency impedance recording system<br>* Patients will be submitted to mapping of both voltage and tissue impedance. The accuracy of the two maps identifying the extent and transmurality of the infarction will be assesssed by gadolinium imaging.<br>* Other names: Cardio-Z;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparative detection of infarct scar by voltage mapping | Voltage will be measured at different sites of the infarct scar and healthy tissue. | 3 hours | 
| Comparative detection of infarct scar by impedance mapping | myocardial local impedance will be measured at different sites of the infarct scar and healthy tissue. | 3 hours | 
| Comparative detection of infarct scar by gadolinium enhanced MR imaging | Intensity of gadolinium will be measured at different sites of the infarct scar and healthy tissue. | 30 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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electrical impedance, cardiac radiofrequency ablation