Prospective Assessment of the Efficacy of Hyaluronate Knee Injections in Patients With Osteoarthritis

Study Overview
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Brief Summary
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This study looks at the effect of an injectable medication called Hyalgan on the cartilage of the knee in people who have osteoarthritis (wear and tear arthritis) of the knee. Hyalgan is a medication which is injected into the knee, and is FDA approved to treat knee arthritis. We will be using magnetic resonance imaging (MRI) and x-rays to look at knee cartilage to see how it responds over the course of a year to the injections. A comparison to patients taking oral pain medication will be made.

Official Title
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Prospective Assessment of the Efficacy of Intra-Articular Hyaluronate to Affect Extracellular Matrix Changes in Patients With Osteoarthritis

Conditions
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Knee Osteoarthritis

Intervention / Treatment
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* Drug: Hyalgan


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age 45-90 seeking medical care for painful knee osteoarthritis alignment based on AP standing radiographs of neutral to 10º of valgus no prior surgery on the ipsilateral knee no history of major trauma to either knee or either hip no history of congenital hip dysplasia No history of inflammatory synovitis or crystalline arthropathy No history of systemic rheumatic disease cruciate and collateral ligament stability, defined by clinical examination meniscus intact (MRI grade II degenerative signal acceptable) Noyes compartment score: no greater than 50% of cartilage thickness over an area greater than 15mm If bilateral OA, the most painful knee, (as documented by VAS scale for pain) which qualifies for the study will be entered. If taking glucosamine chondroitin sulfate, discontinue at least one month prior to HA injections Exclusion Criteria: previous IA HA injection in the ipsilateral knee IA steroid in the ipsilateral knee in the past 3 months MR evidence of inflammatory or hypertrophic synovitis Large joint effusion with a ballotable patella on baseline clinical exam Inability to safely perform MR imaging Active systemic infection Active malignancy (except non-melanomatous skin cancer) Allergies to HA or chicken products Clinical symptoms of an acute meniscal tear (locking, new acute mechanical symptoms etc…) A recent injury to the knee Radiographic evidence of Grade III or IV Kellgren and Lawrence OA Chondrocalcinosis on radiographs Unwilling to discontinue or avoid glucosamine chondroitin sulfate for the 12 month study period People taking blood thinners or who have bleeding problems Anticipated lower extremity surgery during the next 12 months BMI >30 kg/m2

Ages Eligible for Study
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Minimum Age: 45 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Hyalgan|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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hyalgan, knee, osteoarthritis, MRI