Graft Rejection or Tolerance Affected by Serial Change of Anti-donor Lymphocyte Antibody After Liver Transplantation

Study Overview
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Brief Summary
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Liver is an organ that is well-known for its immune tolerant capacity. However, there were still controversial issues about the impact of immunologic challenge after liver transplantation on the graft function. Different results of graft function affected by immunologic factors such as pre-transplant panel reactive antibody (PRA) status, pre-transplant positive lymphocyte cross match (LCM), or post-transplant circulating donor specific antibody (DSA) has been reported according to individual institutes. There was no trial for presenting anti-donor lymphocyte antibody change after liver transplantation. The investigators designed this study to analyze the correlation between pre- and post-transplant immune status (PRA, LCM), and graft survival / rejection episode. Also, the investigators will find aspects of anti-donor lymphocyte antibody change after liver transplantation.

Detailed Description
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Study Design: Target study population is forty patients who will undergo liver transplantation for 1 year in YUHS. Pediatric and early mortality cases will be excluded. Blood sample will be collected at pre-transplant period, post-transplant 7, 14, 21 day, 3 month and 6 month.

Official Title
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Graft Rejection or Tolerance Affected by Serial Change of Anti-donor Lymphocyte Antibody After Liver Transplantation

Conditions
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Liver Transplant Rejection

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Liver recipients who undergo liver transplantation between Mar, 2011 and Feb, 2012 Patients who can be followed for more than 3 months after transplantation Exclusion Criteria: Age under 20 years Multi-organ transplantation Not agree with informed consent Patient who had plant to be transferred to other country or center

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Liver transplant recipients<br>Recipients who will undergo liver transplantation during study period | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| incidence of acute rejection | We designed to analyze the aspects of acute rejection between anti-donor lymphocyte antibody change liver transplantation. | Time point when patients are diagnosed acute rejection | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| correlation between pre- and post-transplant immune status (PRA, LCM), and graft survival | We designed this study to analyze the correlation between pre- and post-transplant immune status (PRA, LCM), and graft survival / rejection episode. | at 7 day, 14 day, 21 day after transplantation and at 3 month, 6 month after transplantation | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Liver transplantation, Rejection, Tolerance