Advancing Brigatinib Properties in ALK+ NSCLC Patients by Deep Phenotyping

Study Overview
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Brief Summary
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This is a prospective, randomized, open-label, multicenter phase II study investigating the advancing Brigatinib properties in anaplastic lymphoma kinase positive non-small cell lung cancer (ALK+ NSCLC) patients by deep phenotyping

Detailed Description
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The aim of this study is to compare efficacy of brigatinib and other 2nd-generation ALK tyrosin kinase inhibitor (TKI) in 1st and 2nd line treatment and to explore resistance patterns according to treatment and molecular properties of the tumors

Official Title
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Advancing Brigatinib Properties in Anaplastic Lymphoma Kinase Positive Non-small Cell Lung Cancer (ALK+ NSCLC) Patients

Conditions
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NSCLC

Intervention / Treatment
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* Drug: Brigatinib
* Drug: Tyrosine kinase inhibitor


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Fully informed written consent and any locally-required authorization (EU Data Privacy Directive) given by the patient Male or female ≥ 18 years of age NOTE: There are no data that indicate special gender distribution. Therefore, patients will be enrolled in the study gender-independently. Histologically confirmed locally advanced (stage III) and not suitable for curative treatment, i.e. R0 operation or definitive chemo-/radiation, or metastatic (stage IV) ALK+ NSCLC NOTE: Documentation of ALK rearrangement by a positive result of any ALK assay approved in Germany [i.e. positivity for at least one of the three: immunohistochemistry (IHC), NGS, fluorescence in situ hybridisation (FISH)] must be available at baseline. Treatment can already be started based on a local ALK+ test result, but subsequent central testing of the baseline biopsy for molecular profiling, incl. determination of ALK variant and TP53 status, should be made possible for all patients. No prior therapy for metastatic ALK+ NSCLC including therapy with ALK inhibitors. However, 1 or 2 cycles of chemotherapy, chemo-immunotherapy or immunotherapy as well as cerebral irradiation before inclusion in the study will be allowed. At least 1 measurable (i.e., target) lesion per RECIST v1.1 or otherwise evaluable lesion (e.g. brain lesion with at least 5 mm of longest diameter if measured by high-resolution cMRT e.g. using 1 mm slices thickness and not planned for irradiation before the first response assessment). Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2 Have adequate organ function, as determined by: Total bilirubin ≤1.5x the upper limit of the normal range (ULN) (< 3x the ULN if Gilbert's disease is present) Estimated glomerular filtration rate ≥30 mL/minute/1.73 m2 (calculated by Modification of Diet in Renal Disease (MDRD) or any other validated formula, see Appendix 13.4) Alanine aminotransferase/aspartate aminotransferase ≤2.5x ULN NOTE: ≤5x ULN is acceptable if liver metastases are present. Serum lipase or serum amylase ≤ 1.5x ULN Platelet count ≥75x 109/L Hemoglobin ≥9 g/dL Absolute neutrophil count ≥1.5x 109/L Willingness and ability to comply with scheduled visit and study procedures Patient willing to participate in accompanying research program Collection of current biopsy during screening must be feasible NOTE: For each patient a formalin-fixed, paraffin-embedded (FFPE) tumor tissue block must be available for biomarker evaluation. Excisional, incisional or core needle biopsies are appropriate, while fine needle aspirations are insufficient. Women of childbearing potential (WOCBP) must have a negative pregnancy test within 7 days prior to randomization. Women must not be breastfeeding. Female patients who: are postmenopausal for at least 1 year before the screening visit, OR are surgically sterile, OR if they are of childbearing potential, agree to practice highly effective non-hormonal contraception from the time of signing the informed consent through at least 4 months after the last dose of study drug, or agree to completely abstain from heterosexual intercourse. Male patients, even if surgically sterilized (i.e., status post-vasectomy), who: agree to practice effective barrier contraception during the entire study treatment period and through at least 3 months after the last dose of study drug, OR agree to completely abstain from heterosexual intercourse. Exclusion Criteria: History or presence at baseline of pulmonary interstitial disease, drug-related pneumonitis, or radiation pneumonitis Uncontrolled hypertension, defined as hypertension treated* with anti-hypertensive drugs AND blood pressure ≥ 160 mmHg (systolic) or ≥ 100 mmHg (diastolic) in repeated measurements. Untreated elevated blood pressure is not an exclusion criterion and should receive adequate anti-hypertensive adjustment. *Please notecase of treatment, at least 3 anti-hypertensive drugs should have been used with the intention to control hypertensive disease Systemic treatment with strong cytochrome P-450 (CYP) 3A inhibitors, strong CYP3A inducers, or moderate CYP3A inducers or treatment with any investigational systemic anticancer agents, chemotherapy or radiation therapy (except for stereotactic radiosurgery or stereotactic radiation therapy or palliative radiotherapy) within 14 days of randomization Treatment with antineoplastic monoclonal antibodies within 30 days of randomization Major surgery within 30 days of randomization. Minor surgical procedures, such as catheter placement or minimally invasive biopsies, are allowed. Current symptomatic spinal cord compression as confirmed by radiographic imaging. Patients with leptomeningeal disease without symptomatic cord compression are allowed. Significant or uncontrolled cardiovascular disease, defined as to the following: If an acute myocardial infarction has ensued in the past 6 months, successful reperfusion has to be documented and the patient has to be free of symptoms New York Heart Association Class III or IV heart failure (i.e. marked limitation in activity due to symptoms, even during less-than-ordinary activity, e.g. walking short distances (20-100 m). Comfortable only at rest) within 6 months prior to randomization Any history of clinically significant ventricular arrhythmia, defined as ventricular tachycardia (VT), ventricular fibrillation (VF), or cardiac arrest Cerebrovascular accident or transient ischemic attack within 6 months prior to first dose of study drug Malabsorption syndrome or other gastrointestinal illness or condition that could affect oral absorption of the study drug Active severe or uncontrolled chronic infection, including but not limited to, the requirement for intravenous antibiotics for longer than 2 weeks History of HIV infection. Testing is not required in the absence of history. Chronic hepatitis B (surface antigen-positive) or chronic active hepatitis C infection. Testing is not required in the absence of history. Any serious medical condition or psychiatric illness that could, in the investigator's opinion, potentially compromise patient safety or interfere with the completion of treatment according to this protocol Known or suspected hypersensitivity to brigatinib or other TKI or their excipients Life-threatening illness unrelated to cancer Involvement in the planning and/or conduct of the study (applies to both Takeda staff and/or staff of sponsor and study site) Patient who might be dependent on the sponsor, site or the investigator Patient who has been incarcerated or involuntarily institutionalized by court order or by the authorities [according to national Medicinal Products Act (Arzneimittelgesetz, AMG)] Patients who are unable to consent because they do not understand the nature, significance and implications of the clinical trial and therefore cannot form a rational intention in the light of the facts [according to national AMG] Legal incapacity or limited legal capacity Females who are pregnant or breastfeeding Patients who have symptomatic CNS metastases (parenchymal or leptomeningeal) at screening or asymptomatic disease requiring an increasing dose of corticosteroids to control symptoms within 7 days prior to randomization. NOTE: If a patient has worsening neurological symptoms or signs due to CNS metastasis, the patient needs to complete local therapy and be neurologically stable (with no requirement for an increasing dose of corticosteroids or use of anticonvulsants) for 7 days prior to randomization. Rare hereditary galactose intolerance, total lactase deficiency or glucose-galactose malabsorption

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Standard Arm with any available ALK TKI<br>st line: Any approved 2nd-generation TKI according to investigator's choice nd line: Any available ALK TKI according to investigator's choice (patients from the standard Arm A can be offered brigatinib in the 2nd line) | Drug: Tyrosine kinase inhibitor<br>* Treatment with any TKI<br>* Other names: Study treatment;|
| Experimental: Experimental Arm with Brigatinib<br>st line: 90 mg brigatinib once daily p.o. for the first 7 days (lead-in) followed by 180 mg brigatinib once daily p.o. afterwards, starting with day 8 nd line: Any available ALK TKI according to investigator's choice | Drug: Brigatinib<br>* Treatment with Brigatinib<br>* Other names: Study treatment;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Progression-free survival (PFS) of 1st-line treatment according to RECIST v1.1 | Time from the first dosing date of any study medication to the date of the first objectively documented tumor progression or death due to any cause | 68 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| PFS of 2nd-line treatment according to RECIST v1.1 | Time from the first dosing date of any 2nd-line TKI to the date of the objectively documented tumor progression or death due to any cause | 68 months | 
| TNT 1st line (TNT1, i.e. time-to-next treatment for the 1st line) | Time from begin of 1st-line treatment until begin of 2nd-line treatment | 68 months | 
| TNT 2nd line (TNT2, i.e. time-to-next treatment for the 2nd line | Time from begin of 2nd line until begin of 3rd-line treatment | 68 months | 
| TNT1/2 (time-to-next treatment for the 1st and 2nd line together) | Time from begin of 1st-line treatment until begin of 3rd-line treatment | 68 months | 
| Overall survival (OS) | Time from treatment start in the 1st line to the date of death (due to any cause) | 68 months | 
| Intracranial ORR (iORR) | Percentage of participants with a best overall intracranial response (BOR) of intracranial complete response (CR) or intracranial partial response (PR). Best overall intracranial response (BOR) is defined as the best response designation, recorded between the date of first dose and the date of the initial objectively documented intracranial tumor progression per RECIST criteria or the date of subsequent therapy or death, whichever occurs first. | 68 months | 
| Intracranial DOR (iDOR) according to RECIST v1.1 | Time from first documentation of intracranial CR or PR according to RECIST v1.1 (whichever is first recorded) until the first date that the intracranial progressive disease (PD) is objectively documented or until death (whichever occurs first | 68 months | 
| Time to intracranial progression (TTiP) | Time from start of 1st-line treatment until the occurrence of a new central nervous system (CNS) lesion or progression of pre-existing CNS lesions | 68 months | 
| Safety (rate of adverse events) | Type, incidence and severity of adverse events (AEs) and serious adverse events (SAEs)graded according to NCI CTCAE v5.0 | 68 months | 
| Quality of life (QoL) assessed by SF-12-questionnaire | Patient reported outcome assessed by the validated SF-12-questionnaire | 68 months | 
| Quality of life (QoL) assessed by EORTC-quality of life questionnaire (QLQ)-BN20-questionnaire | Patient reported outcome assessed by the validated EORTC-QLQ-BN20-questionnaire | 68 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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ALK+ NSCLC, Resistance patterns, Molecular properties