Deep Learning for Classification of Scheimpflug Corneal Tomography Images

Study Overview
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Brief Summary
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Keratoconus is a common disorder. An early diagnosis influences the disease prognosis in the affected patients and prevents postoperative complications in patients with keratoconus considering refractive surgery. Machine learning approaches have been widely used for image classification. Here, we will assess the ability of deep learning to enable high-performance image classification of the color-coded corneal maps obtained by Scheimpflug camera in patients with keratoconus, subclinical keratoconus, and normal individuals.

Official Title
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Classification of Color-Coded Scheimpflug Camera Corneal Tomography Images Using Deep Learning

Conditions
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Eye Diseases

Intervention / Treatment
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* Other: Scheimpflug Camera Corneal Tomography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Keratoconus group: Presence of a central protrusion of the cornea with Fleischer ring, Vogt striae, or both by slitlamp examination. irregular cornea determined by distorted keratometry mires and distortion of retinoscopic red reflex or both in addition to the following topographic findings as summarized by Pińero and colleagues : focal steepening located in a zone of protrusion surrounded by concentrically decreasing power zones focal areas with diopteric (D) values >47.0D inferior- superior(I-S) asymmetry measured to be > 1.4 D Angling of the hemimeridians in an asymmetric or broken bowtie pattern with skewing of the steepest radial axis(SRAX) . Suspicious group: • Defined as subtle corneal tomographic changes as the aforementioned keratoconus abnormalities in the absence of slit- lamp or visual acuity changes typical of keratoconus (forme fruste keratoconus). Normal group: Refractive surgery candidates Refractive error of less than 8.0 D sphere Less than 3.0 D of astigmatism without clinical, topographic or tomographic signs of keratoconus or suspect keratoconus. Exclusion Criteria: Systemic disease Other corneal disease such as pellucid marginal degeneration History of trauma Corneal surgery such as corneal cross- linking for progressive keratoconus.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Keratoconus<br>Those with a clinical diagnosis of keratoconus such as: a) the presence of a central protrusion of the cornea with Fleischer ring, Vogt striae, or both by slitlamp examination.(b) an irregular cornea determined by distorted keratometry mires and distortion of retinoscopic red reflex or both in addition to the following topographic findings as summarized by Pińero and colleagues: focal steepening located in a zone of protrusion surrounded by concentrically decreasing power zones, focal areas with dioptric (D) values >47.0D, inferior- superior(I-S) asymmetry measured to be > 1.4 D or angling of the hemimeridians in an asymmetric or broken bowtie pattern with skewing of the steepest radial axis (SRAX) 2. | Other: Scheimpflug Camera Corneal Tomography<br>* Pentacam Sheimpflug system(Pentacam HR, Oculus Optikgeräte GmbH, software V.1.15r4 n7) is used for imaging of the anterir and posterior surfaces of the cornea to obtain corneal tomographic maps.<br>|
| Subclinical keratoconus<br>Defined as subtle corneal tomographic changes as the aforementioned keratoconus abnormalities in the absence of slit- lamp or visual acuity changes typical of keratoconus (subclinical keratoconus). | Other: Scheimpflug Camera Corneal Tomography<br>* Pentacam Sheimpflug system(Pentacam HR, Oculus Optikgeräte GmbH, software V.1.15r4 n7) is used for imaging of the anterir and posterior surfaces of the cornea to obtain corneal tomographic maps.<br>|
| Normal<br>This group comprised refractive surgery candidates and subjects applying for a contact lens fitting with a refractive error of less than 8.0 D sphere with less than 3.0 D of astigmatism and without clinical, topographic or tomographic signs of keratoconus nor suspected keratoconus. | Other: Scheimpflug Camera Corneal Tomography<br>* Pentacam Sheimpflug system(Pentacam HR, Oculus Optikgeräte GmbH, software V.1.15r4 n7) is used for imaging of the anterir and posterior surfaces of the cornea to obtain corneal tomographic maps.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Croppedm denoised, and resized to obtain four separate image stacks of 256×256 pixels |  | 2 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Keratoconus, Deep learning, Scheimpflug camera, Corneal tomography