Effect of Agaricus Blazei (Murrill) ss. Heinemann (Sun Mushroom)

Study Overview
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Brief Summary
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The aim of the study was to verify the influence of Agaricus blazei (Murrill) ss. Heinemann (A. blazei) on the evolution of nutritional state and liver function in hepatitis C patients.

Detailed Description
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Ten patients were studied (5 - GI - not taking A. blazei - and 5 - G2 - taking A. blazei), from both sexes, with positive Anti-VHC and a healthy nutritional state, admitted into in the viral hepatitis ward. Diagnosis and treatment for hepatitis C concurred with the regulations of the Ministry of Health and nutritional evaluation was performed in 3 moments according to anthropometrical, bioimpedance, biochemical and dietary standards, with duration of 6 months. The consumption of A. blazei (10g/day) in dehydrated powder was concomitant with antiviral therapy (conventional or pegylated interferon associated with ribavirin) with duration of 5 months.

Official Title
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Effect of Agaricus Blazei (Murrill) ss. Heinemann (Sun Mushroom) on the Nutritional State and Liver Biochemistry in Hepatitis C Patients.

Conditions
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Hepatitis C, Nutritional Status, Hepatitis, Viral, Human

Intervention / Treatment
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* Dietary Supplement: Agaricus blazei (Murrill) ss. Heinemann (sun mushroom)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: To have been informed and signed adequately the free and clarified assent Initiating the anti-viral treatment (interferon or pegylated interferon associate the ribavirin) Age: 24-70 years Gender :both the gender Race : all races To present serology positive to the anti-VHC ELISA To present genotype type 1,2,or 3 Body mass index- >18,5 e < 35kg /m2 Conditions full to the ORAL ingestion Exclusion Criteria: Don't agree to the project or don't have signed the term of clarified free assent Restriction for oral ingestion The existence of surface of antigen of the hepatitis B virus(Ag HBs) The existence of antibody for the human immunodeficiency virus To be enclosed in another project of research or form of treatment Pregnant women Suckles Cirrhosis Patients with hepatitis auto-imune.

Ages Eligible for Study
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Minimum Age: 24 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: G1<br> | |
| Experimental: G2<br> | Dietary Supplement: Agaricus blazei (Murrill) ss. Heinemann (sun mushroom)<br>* Agaricus blazei powder, 10 grams/day, for 5 months<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measure: influence of Agaricus blazei (Murrill) ss. Heinemann on the evolution of nutritional state and liver function in hepatitis C patients. Time Frame: six months |  | Time Frame: six months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Agaricus blazei (Murrill) ss. Heinemann,, Hepatitis C, Nutritional status, Liver Function Tests, Antiviral Agents