Iron Overload and Growth Velocity in Thalassemia and Sickle Cell Anemia

Study Overview
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Brief Summary
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Iron overload impaired growth in Thalassemia patients due to iron deposition in the endocrine glands, including the hypophysis and gonads. The issue of iron overload in Sickle Cell Anemia is recently studied more extensively and preliminary studies shows that endocrine damage is rarer in those patients. Growth velocity was not systematically studied in patients with Iron Overload, even in thalassemia patients in spite several studies that assess the endocrine function in those patients. In Sickle Cell Patients this issue was not studied. The purpose of this study is to assess the growth velocity in a cohort of Thalassemia Major and Intermedia patients and compare the results to another group of Sickle Cell patients, including Sickle cell thalassemia.

Detailed Description
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Growth velocity, endocrine function and iron overload status will be studied in the patients that are in follow up at the Pediatric Hematology Unit, at the Ha'Emek Medical Center. Patients who were lost from follow up or insufficient data about growth in the past will not included in the study.

Official Title
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Iron Overload and Growth Velocity in Thalassemia and Sickle Cell Anemia

Conditions
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Thalassemia, Sickle Cell Disease

Intervention / Treatment
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* Other: Medical Chart Summary


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All patients in follow up with available medical charts. Exclusion Criteria: Patients lost from follow up or without enough data to calculate growth velocity or clinical and laboratory endocrine assessment or missing data about iron status.

Ages Eligible for Study
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Minimum Age: 5 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Thalassemia Group<br>Patients suffering from Thalassemia Major and patients with Thalassemia Intermedia | Other: Medical Chart Summary<br>* Summary of the Medical Files including annual growth velocity, endocrine function and iron overload status.<br>|
| Sickle Cell Group<br>Patients with Sickle Cell Anemia and Sickle Cell Thalassemia | Other: Medical Chart Summary<br>* Summary of the Medical Files including annual growth velocity, endocrine function and iron overload status.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Iron Overload and Growth Velocity in Thalassemia and Sickle Cell Anemia | Analysis of Growth Velocity in Thalassemia and Sickle Cell Anemia and correlation with Iron Overload | One year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Thalassemia Major, Thalassemia Intermedia, Sickle Cell Anemia, Sickle Cell Thalassemia, Iron Overload, Growth Velocity