The Personalized Chinese Herb Formulas Over Hypertensive Bradyarrhythmia

Study Overview
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Brief Summary
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72 patients who have been diagnosed with hypertensive bradyarrhythmia were selected and randomly divided into research group and control group. The research group received regular medication against hypertension and the personalized formulas based on syndrome differentiation, meanwhile the control group only received the regular medication. The five symptoms (palpitation, short of breath, angina, dizzy and lumbar debility) were graded and used for evaluation of treatment.

Detailed Description
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To test the effect of Chinese herb against the hypertensive heart disease, we designed this randomized controlled clinical trial. 72 patients who have been diagnosed with hypertensive bradyarrhythmia were selected and randomly divided into research group and control group. The five symptoms (palpitation, short of breath, angina, dizzy and lumbar debility) were graded. The research group received regular medication against hypertension and the personalized formulas based on syndrome differentiation, meanwhile the control group only received the regular medication. 2 weeks after treatment, all the symptoms were graded again.

Official Title
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The Personalized Chinese Herb Formulas Are Evaluated for Their Effectiveness to Relieve Symptoms in Hypertensive Bradyarrhythmia

Conditions
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Hypertensive Heart Disease

Intervention / Treatment
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* Drug: Safflower (Carthamus Tinctorius) IgG4 &#X7C; Serum &#X7C; Allergy
* Drug: Atropine Sulfate


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: * Clinical diagnosis of hypertensive bradyarhhythmia Exclusion Criteria: With other elementary diseases With pregnant With receiving other treatment within past half year from the beginning of trial.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Research group<br>The patients receiving Atropine and the extra Chinese herb formulas treatment | Drug: Safflower (Carthamus Tinctorius) IgG4 &#X7C; Serum &#X7C; Allergy<br>* The designed Chinese herb formulas<br>* Other names: Xuefuzhuyu;Drug: Atropine Sulfate<br>* The basic treatment for heart disease<br>|
| Active Comparator: Control group<br>The patients receiving the basic treatment of atropine | Drug: Atropine Sulfate<br>* The basic treatment for heart disease<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| typical symptoms in patients with hypertensive bradyarrhythmia | The five indexes of typical symptoms in patients with hypertensive bradyarrhythmia (palpitation, angina, shortness of breath, dizzy, lumbar debility) were evaluated and scored both before treatment and after treatment according to Guiding principles for clinical research of new Chinese Medicine. | 2 weeks |