Postcapillary Blood Gas Analysis in Wedge Position (Wedge-BGA)

Study Overview
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Brief Summary
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If pulmonary hypertension is suspected, a right heart catheterization is usually performed to confirm or rule out the diagnosis. As part of this examination, blood samples are taken from various locations as standard and blood gas analyses are performed. One of the most important measurements during the right heart catheterization is the measurement of the pulmonary arterial occlusion pressure by the so-called wedge maneuver. To measure this value, the catheter with inflated balloon must be advanced into the pulmonary vessels until the wedge position is reached, i.e. the balloon completely occludes a branch of the pulmonary artery. In this study, the investigators want to characterize patients with pulmonary hypertension of different causes in more detail. To do that, two blood samples (totaling approximately 4 mL of blood, one sample directly after occlusion and the other one two minutes later) will be drawn during the right heart catheterization from the above-mentioned wedge position, behind the inflated balloon, and blood gas analyses will be performed on these samples. In addition, various clinical parameters (comorbidities, etc.) will be recorded by means of clinical questionnaires. Follow-up data will be analyzed and correlations with the aforementioned blood gas analyses will be examined. The results of the study will be used to more precisely characterize the still vague concept of secondary pulmonary hypertension. This could help to develop new therapeutic strategies in some subgroups in the future.

Official Title
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Blood Gas Analysis Obtained in Pulmonary Capillary Wedge Position During Right Heart Catheterization

Conditions
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Pulmonary Hypertension

Intervention / Treatment
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* Diagnostic Test: Blood gas analysis


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients who have a clearly defined indication for Right heart catheterization. Age > 18 years Informed consent for participation in the study will sign Exclusion Criteria: Individuals who are not fully capable of giving consent and understanding the nature, significance, and scope of the study Pregnancy and lactation

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 99 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No pulmonary Hypertension<br> | Diagnostic Test: Blood gas analysis<br>* Two blood samples will be drawn from the wedge position, behind the inflated balloon, during the right heart catheterization, and blood gas analyses will be performed. First sample will be drawn directly after inflating the ballon, and the second one 2 minutes later.<br>|
| pulmonary Hypertension Group 1<br> | Diagnostic Test: Blood gas analysis<br>* Two blood samples will be drawn from the wedge position, behind the inflated balloon, during the right heart catheterization, and blood gas analyses will be performed. First sample will be drawn directly after inflating the ballon, and the second one 2 minutes later.<br>|
| pulmonary Hypertension Group 2<br> | Diagnostic Test: Blood gas analysis<br>* Two blood samples will be drawn from the wedge position, behind the inflated balloon, during the right heart catheterization, and blood gas analyses will be performed. First sample will be drawn directly after inflating the ballon, and the second one 2 minutes later.<br>|
| pulmonary Hypertension Group 3<br> | Diagnostic Test: Blood gas analysis<br>* Two blood samples will be drawn from the wedge position, behind the inflated balloon, during the right heart catheterization, and blood gas analyses will be performed. First sample will be drawn directly after inflating the ballon, and the second one 2 minutes later.<br>|
| pulmonary Hypertension Group 4<br> | Diagnostic Test: Blood gas analysis<br>* Two blood samples will be drawn from the wedge position, behind the inflated balloon, during the right heart catheterization, and blood gas analyses will be performed. First sample will be drawn directly after inflating the ballon, and the second one 2 minutes later.<br>|
| pulmonary Hypertension Group 5<br> | Diagnostic Test: Blood gas analysis<br>* Two blood samples will be drawn from the wedge position, behind the inflated balloon, during the right heart catheterization, and blood gas analyses will be performed. First sample will be drawn directly after inflating the ballon, and the second one 2 minutes later.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Risk group after 3-6 months | Standardized clinical outcome parameters after 3-6 months | 3-6 months |