Efficacy of Compound Betamethasone Injection Combined With Ropivacaine in Ultrasound-guided Intercostal Nerve Block for Chronic Post-thoracotomy Pain

Study Overview
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Brief Summary
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The patients were divided into two groups by random number method: GroupRD1 group and GroupRD2 group were given general anesthesia and intercostal nerve block.The drug for intercostal nerve block was 0.33% ropivacaine +2.333mg compound betamethasone (1.667mg betamethasone dipropionate + 0.667mg betamethasone sodium phosphate) to 15ml.

Detailed Description
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The RD1 group received ultrasound-guided intercostal nerve block at the incision before anesthesia induction, and the RD2 group received ultrasound-guided intercostal nerve block at the lateral costal Angle before anesthesia induction.

Official Title
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Efficacy of Compound Betamethasone Injection Combined With Ropivacaine in Ultrasound-guided Slit Intercostals Nerve Block for Chronic Post-thoracotomy Pain:A Single Blind Randomized Control Trial

Conditions
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Nerve Block

Intervention / Treatment
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* Other: intercostal nerve block
* Other: lateral intercostal nerve block
* Drug: ropivacaine + compound betamethasone


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 18-70 years old ASA grade I-III BMI: 18.5-28kg/m2 Type of surgery: elective thoracoscopic lung mass resection Informed consent has been signed by the patient and/or family members Exclusion Criteria: game anesthesia or sugar cortical hormone drugs allergic preoperative use of opioid medicines serious blood coagulation dysfunction serious heart, lung, liver and renal insufficiency put, chemotherapy, and glucocorticoid immunosuppressive therapy history or diseases of the immune system peptic ulcer newly gastrointestinal surgery has a history of thoracic surgery is the central nervous system disease Other glucocorticoids should be used with caution in patients such as fractures, wound repair, corneal ulcers, hyperadrenocortical disease, diabetes mellitus, pregnant women, etc.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: intercostal nerve block at the incision<br>General anesthesia and intercostal nerve block were performed.The drug for intercostal nerve block was 0.33% ropivacaine +2.333mg compound betamethasone (1.667mg betamethasone dipropionate + 0.667mg betamethasone sodium phosphate) to 15ml | Other: intercostal nerve block<br>* General anesthesia and intercostal nerve block were performed. The drug for intercostal nerve block was 0.33% ropivacaine +2.333mg compound betamethasone (1.667mg betamethasone dipropionate + 0.667mg betamethasone sodium phosphate) to 15ml<br>Drug: ropivacaine + compound betamethasone<br>* The drug for intercostal nerve block was 0.33% ropivacaine +2.333mg compound betamethasone (1.667mg betamethasone dipropionate + 0.667mg betamethasone sodium phosphate) to 15ml<br>|
| Active Comparator: lateral intercostal nerve block at costal angle<br>General anesthesia and intercostal nerve block were performed.The drug for intercostal nerve block was 0.33% ropivacaine +2.333mg compound betamethasone (1.667mg betamethasone dipropionate + 0.667mg betamethasone sodium phosphate) to 15ml | Other: lateral intercostal nerve block<br>* lateral intercostal nerve block<br>Drug: ropivacaine + compound betamethasone<br>* The drug for intercostal nerve block was 0.33% ropivacaine +2.333mg compound betamethasone (1.667mg betamethasone dipropionate + 0.667mg betamethasone sodium phosphate) to 15ml<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Acute and chronic postoperative pain | Numeric rating scale(NRS) is used to assess acute postoperative pain | 6 hours after surgery | 
| Acute and chronic postoperative pain | Numeric rating scale(NRS) is used to assess acute postoperative pain | 24 hours after surgery | 
| Acute and chronic postoperative pain | Numeric rating scale(NRS) is used to assess acute postoperative pain | 48 hours after surgery | 
| Acute and chronic postoperative pain | Numeric rating scale(NRS) is used to assess acute postoperative pain | 1 months after surgery | 
| Acute and chronic postoperative pain | Numeric rating scale(NRS) is used to assess acute postoperative pain | 3 months after surgery |