Involuntary Memories Investigation in Schizophrenia

Study Overview
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Brief Summary
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Patients with schizophrenia suffer from autobiographical memory disorders. Patients have difficulty to remember vividly personal past events when they are specifically asked for. Indeed, this task requires a good executive functioning to retrieve precise information stored in long term memory. Interestingly, executive functioning has been showed impaired in schizophrenia and studies showed that their autobiographical memory impairments were directed related to their executive dysfunction. Yet, in daily life people remember more often autobiographical memories spontaneously, without trying voluntarily to recall them. In that case, the involuntary recall of personal past events is much less sustained by executive functioning. In this protocol the investigators would like to investigate and compare subjective characteristics of involuntary and voluntary autobiographical memories in order to highlight the role of executive dysfunction in patients' autobiographical memory impairments.

Official Title
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Involuntary Memories Investigation in Schizophrenia

Conditions
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Schizophrenia

Intervention / Treatment
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* Other: Patients with Schizophrenia


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: - for patients only male or female age limits : 18-55 years old under the protection of health insurance who have signed up the consent form schizophrenia or schizo-affective disorder according to the DSM-5 criteria (APA, 2013). clinically stable for at least 2 months patients under guardianship or curatorship need agreement of their legal representative informed of the results of prior medical examination for controls only male or female age limits : 18-55 years old under the protection of health insurance who have sign up the consent form recruited from the general population and matched on gender, age years of schooling no psychiatric history (DSM-5) Exclusion Criteria: for both patients and controls current severe or unstable somatic illness neurological history (brain injury > 15 minutes loss of consciousness , epilepsia, brain surgery…) current substance use disorder (DSM-5) current major depressive disorder (CDSS,BDI, HDRS) mental retardation (IQ < 70, WAIS-4, f-NART) history of general anesthesia 3 months prior to the experiment pregnancy declared by the subject breast feeding current legal control in emergency situation included during exclusion period in another experiment for controls only taking of antipsychotic drugs for the 3 weeks prior to inclusion under guardianship or curatorship

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Health Services Research
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Control group<br>Control participants without psychiatric nor neurological history | Other: Patients with Schizophrenia<br>* Patients with schizophrenia or schizoaffective disorder according to DSM-V criteria<br>|
| Experimental: Patients with Schizophrenia<br>Patients with schizophrenia or schizoaffective disorder according to DSM-V criteria | Other: Patients with Schizophrenia<br>* Patients with schizophrenia or schizoaffective disorder according to DSM-V criteria<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Autobiographical subjective score taking into account memories vividness and specifity |  | 8 months |