linjc16/ctgov huggingface dataset:
Forces and Translation Distance During an Inferior Glide of the Shoulder

Study Overview
=================
Brief Summary
-----------------
This study evaluates the force and translation distance in the GH joint during a manual inferior glide of the humerus.

Detailed Description
-----------------
There has been limited research on how the variance of force affects MT outcomes and what the best practices of MT should be. No specific force threshold necessary to achieve a predetermined translational distance within the joint has been quantified within the literature. The purpose of this study was to quantify the amount of force necessary to perform an inferior glide to the glenohumeral joint and reach to end-range. A secondary aim was to determine the impact of co-variables, such as gender, height, weight, and age, on the amount of force required to translate the humeral head within the glenohumeral joint. Musculoskeletal Ultrasound imaging using the GE LogiQe was used to measure the translation of the humeral head. The manipulation force was measured using the Novel Pliance Glove device and software.

Official Title
-----------------
Forces and Translation Distance During an Inferior Glide of the Shoulder in Healthy Subjects Measured With the Novel Pliance Glove and Ultrasound Imaging

Conditions
-----------------
Asymptomatic Condition

Intervention / Treatment
-----------------
* Procedure: Inferior glide humerus in GH joint


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy volunteers Able to read the English language fluently Exclusion Criteria: a history of injury of the right shoulder right shoulder surgery presence of shoulder pain comorbidities affecting natural ROM within the dominant shoulder

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Interventional Model Description: Within subject design
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: inferior glide<br>Inferior glide of the right humerus till no motion is visual on the imaging | Procedure: Inferior glide humerus in GH joint<br>* Supine inferior glide GH joint<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Translation | Measured in mm using MSK Ultrasound | 5 minutes | 
| Force measure | Force measure during inferior glide using Novel Pliance Glove | 5 minutes | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Manipulation force, Glenohumeral joint, Musculoskeletal Ultrasound Imaging
fMRI Study of Brain Mechanisms Related to Emotions

Study Overview
=================
Brief Summary
-----------------
The purpose of the study is to better define and understand the brain mechanisms related to emotional and cognitive dimensions using odorous stimuli, gustatory stimuli, visual stimuli and auditory stimuli using functional Magnetic Resonance Imaging (fMRI).

Official Title
-----------------
Imagerie Fonctionnelle cérébrale: Aspects Normaux et Pathologiques

Conditions
-----------------
Neuroimaging

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: right-handed Healthy Volunteers Exclusion Criteria: those applied for an magnetic resonance examination

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cerebral activation of subjects using Blood Oxygenation Level Dependant (BOLD) contrast imaging | measure brain activity by the BOLD technical | at admission |
Hip and Knee Moments Normal and With Scoliosis

Study Overview
=================
Brief Summary
-----------------
Kinetic analysis appears to be useful in providing objective information regarding the gait abilities of scoliotic patients which is difficult to be observed in a clinical setting. Objective: the aim of the study was to analyze the hip and knee peak abductor moments during gait in subjects with idiopathic scoliosis.

Detailed Description
-----------------
The hip and knee abductors' moments normalized to body weight have been investigated in normal subjects and subjects with idiopathic scoliosis. The scoliosis group included a twenty-two-moderate idiopathic dorso-lumbar single scoliotic curve. The control group contained a normal twenty-two subjects. 3D motion analysis system and force plat were used for data collection for hip and knee abductor moment. MANOVA was used to study the difference between normal and scoliotic groups' hip and knee abductor moments in both lower limbs. at alpha level of significance of 0.05.

Official Title
-----------------
Hip and Knee Abductor Moments in Normal Subjects and Subjects With Idiopathic Scoliosis: Comparative Study

Conditions
-----------------
Scoliosis Idiopathic

Intervention / Treatment
-----------------
* Other: gait analysis


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: normal subjects free from any musculoskeletal problems subjects with moderate idiopathic scoliosis (cobb angle 25-35) Exclusion Criteria: any musculoskeletal affection rather than scoliosis, neurological manifestations, or previous major surgeries

Ages Eligible for Study
-----------------
Minimum Age: 14 Years
Maximum Age: 17 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Normal<br>normal subjects | Other: gait analysis<br>* Vicon nexus with MTI force plate form<br>|
| Scoliosis<br>subjects with moderate idiopathic scoliosis | Other: gait analysis<br>* Vicon nexus with MTI force plate form<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| hip and knee abductor moment | peak abductor moment normalized to body weight | one session of 40 minutes. | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Idiopathic scoliosis-gait-moment
Stellate Block Versus Nimodipine Infusion for Traumatic Brain Injury

Study Overview
=================
Brief Summary
-----------------
the study is designed to perform an intervention for enhancement of cerebral blood flow in patients with traumatic brain injury showing vasospasm through transcranial doppler

Official Title
-----------------
Ultrasound-guided Stellate Ganglion Block Versus Nimodipine Infusion for Enhancement of Cerebral Blood Flow in Traumatic Brain Injury

Conditions
-----------------
Traumatic Brain Injury

Intervention / Treatment
-----------------
* Procedure: ultrasound-guided stellate ganglion block


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients more than 18 ys old with isolated head trauma and traumatic brain injury Exclusion Criteria: • Hemodynamic instability (mean ABP less than 70 mmHg) History of severe systemic disease including cardiopulmonary failure or hepatorenal failure Allergy to local anesthetics Coagulation disorders Abnormal neck structures disturbing normal anatomy as neck tumors

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: ultrasoung guided stellate block<br>stellate ganglion will have ultrasound-guided block via bupivacaine for sympathectomy and enhancement of cerebral blood flow | Procedure: ultrasound-guided stellate ganglion block<br>* under aseptic conditions, using the ultrasound guidance, bilateral stellate ganglion block will be done using bupivacaine and betamethasone mixture, 8 ml volume will be given for each side<br>|
| Active Comparator: nimodipine infusion<br>intravenous nimodipine will be given for enhancement of cerebral blood flow | Procedure: ultrasound-guided stellate ganglion block<br>* under aseptic conditions, using the ultrasound guidance, bilateral stellate ganglion block will be done using bupivacaine and betamethasone mixture, 8 ml volume will be given for each side<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| enhancement of cerebral blood flow | increased blood flow through middle cerebral artery and basilar artery measured by transcranial doppler ultraound | one week |
The Influence of Pressure Pain on [11C]Diprenorphine Binding Potentials

Study Overview
=================
Brief Summary
-----------------
Healthy volunteers aged 21 to 50 are needed for a research study investigating whether pain will alter the binding properties of ([11C]diprenorphine), a molecule that can be used during brain imaging. Positron Emission Tomography (PET) and functional Magnetic Resonance (fMRI) imaging will be used in this study.

Official Title
-----------------
The Influence of Pressure Pain on [11C]Diprenorphine Binding Potentials

Conditions
-----------------
Healthy Controls

Intervention / Treatment
-----------------
* Radiation: PET imaging


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy male and female adults, 21 to 50 years of age No contraindications to fMRI and PET scanning Within 15% of ideal body mass index (BMI) Exclusion Criteria: Current significant medical, neurological, or psychiatric illness as assessed by the Physician Investigators Women who are pregnant or breast feeding, have gone through menopause, and/or have irregular menstrual cycles Claustrophobia History of head trauma Instability of responses to experimental pain (See Study Procedure Section Part II) History of asthma Use of psychotropic drugs or hormone treatments (including hormonal birth control) within one year of date of consent History of smoking Routine exercise in excess of one hour per day and/or three times per week Non-fluent English speaker

Ages Eligible for Study
-----------------
Minimum Age: 21 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: healthy controls<br> | Radiation: PET imaging<br>* Up to a 120 minute PET scan using [11C]diprenorphine as the radiotracer<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| PET/MRI Brain Activation | Simultaneously collect fMRI-PET data in humans to investigate the change between bold signal evoked by pressure pain and bold signal evoked by non-painful pressure. The PET analyses generates one value per 120 minutes. This value is compared to the other 120 minute scan PET value in order to reflect the change. | day one |
Reliability, Validity Of The Turkish Version Of The Back Performance Scale

Study Overview
=================
Brief Summary
-----------------
In this study, we performed the validity and reliability of the Turkish version of Back Performance Scale.

Detailed Description
-----------------
Low back pain (LBP) is defined as the pain that occurs in the area between the lower border of the scapula and the buttocks and sometimes radiates to the lower extremities. In the community, lower back pain is the second most common health problem after cold. 15% of LBP cases are chronic. Appropriate use of assessment questionnaires is one of the most important steps in the evaluation of the functional level of the patient and in deciding on an effective treatment protocol. The purpose of study is to determine the Turkish version, validity and reliability of Back Performance Scale. 180 patients with chronic low back pain were included in the study. Test-retest and internal consistency analysis were conducted to determine the reliability of the questionnaire. Test-retest results evaluated using the Intraclass Correlation Coefficient method.

Official Title
-----------------
Reliability, Validity Of The Turkish Version Of The Back Performance Scale

Conditions
-----------------
Low Back Pain

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Having a low back pain Literate persons Exclusion Criteria: Cancer disease Trauma Pregnant

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Roland Morris disability questionnaire | Roland Morris Disability Questionnaire, a widely used health status measure for low back pain. The RMDQ can be used in research or clinical practice. | 10 minute | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Oswestry Low Back Pain Disability Questionnaire | The Oswestry Disability Index (ODI) has become one of the principal condition-specific outcome measures used in the management of spinal disorders | 10 minute | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
low back pain, validity, reliability
Methods Study to Characterize Early Indicators of Weight Loss in People

Study Overview
=================
Brief Summary
-----------------
Methods study to characterize early indicators of weight loss in people.

Official Title
-----------------
A Randomized, Open-Label, Parallel Group, Fixed Energy Deficit Methodology Trial to Characterize Early Efficacy Biomarkers During Treatment of Obesity in Adult, Obese, Male Subjects.

Conditions
-----------------
Obesity

Intervention / Treatment
-----------------
* Behavioral: caloric restriction - 10%
* Behavioral: caloric restriction - 25%
* Behavioral: caloric restriction - 50%
* Behavioral: caloric restriction - Control


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Subjects >=18 years of age with BMI >= 30 and < 40 kg/m2 Exclusion Criteria: Females, those with illnesses expected to cause weight loss, those without stable body weight within 3 months of screening.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 10%<br> | Behavioral: caloric restriction - 10%<br>* Subjects maintained on 10% caloric restriction (caloric intake = 90% of baseline)<br>|
| Experimental: 25%<br> | Behavioral: caloric restriction - 25%<br>* Subjects maintained on 25% caloric restriction (caloric intake = 75% of baseline)<br>|
| Experimental: 50%<br> | Behavioral: caloric restriction - 50%<br>* Subjects maintained on 50% caloric restriction (caloric intake = 50% of baseline)<br>|
| Placebo Comparator: Control<br> | Behavioral: caloric restriction - Control<br>* Subjects maintained on their baseline caloric intake (caloric restriction = none)<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To evaluate the effect of varying degrees of controlled, 1-month, caloric restriction on weight loss, and response of known circulating, candidate biomarkers |  | Throughout trial | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To evaluate the time course, magnitude and biomarkers of metabolic compensation as well as assessment of well being (via questionnaires) following varying degrees of controlled, 1-month, caloric restriction |  | Throughout trial |
Correlation of Airflow Limitation and Other Respiratory Characteristics With Radiologic Changes of Lung Structure

Study Overview
=================
Brief Summary
-----------------
The aim of the study is to assess the correlation between airflow limitation, perception of dyspnea and functional capacity with anatomic changes in pulmonary structure as seen on High Resolution CT in COPD patients.

Conditions
-----------------
Chronic Obstructive Pulmonary Disease

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Clinical diagnosis of COPD Able to perform pulmonary function testing Exclusion Criteria: Pregnant women

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| COPD patients<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Selegiline Transdermal System for the Treatment of Cocaine Dependence - 1

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate the Selegiline Transdermal System for the treatment of cocaine dependence.

Detailed Description
-----------------
The study objectives are to assess the efficacy and safety of the Selegiline Transdermal System (STS) in reducing cocaine use in subjects with cocaine dependence. It is hypothesized that selegiline treatment compared to placebo, will be associated with fewer days of cocaine use as assessed by self-report confirmed with urine assays for benzoylecgonine (BE).

Official Title
-----------------
Double-Blind, Placebo-Controlled Trial of Selegiline Transdermal System for the Treatment of Cocaine Dependence

Conditions
-----------------
Cocaine-Related Disorders

Intervention / Treatment
-----------------
* Drug: Selegiline


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Male/Female At least 18 years of age DSM-4 diagnosis of cocaine dependence Ability to understand and provide written consent Female subjects must use acceptable birth control Exclusion Criteria: - Additional Criteria available during the screening process at the site.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Quadruple


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Selegiline|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Weekly mean proportion of cocaine non-use days |  |  | 
| Measured reductions in cocaine and other drug use |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Cocaine Dependence
Prevention of Neutropenia After Using G-CSF With TAC Chemotherapy

Study Overview
=================
Brief Summary
-----------------
After resection of lymph node positive breast cancer, the injection duration and timing of Granulocyte-colony stimulating factor (G-CSF) could affect the neutropenia with TAC (Taxotere, Adriamycin, cyclophosphamide) chemotherapy.

Detailed Description
-----------------
The duration and the injection timing of G-CSF are effective in the prevention of neutropenia, incidence of infection and non hematologic toxicity. With the TAC chemotherapy after resection of breast cancer, the G-CSF early injection versus late injection could change the frequency of neutropenia.

Official Title
-----------------
Optimal Timing and Duration of Daily G-CSF With Adjuvant TAC Chemotherapy in Node-positive Breast Cancer;Multicenter, Randomized, Open Label, Clinically IV Phase

Conditions
-----------------
Neutropenia

Intervention / Treatment
-----------------
* Drug: late leukostim
* Drug: early leukostim


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: primary invasive breast carcinoma with lymph node positive with curative surgery with TAC chemotherapy Exclusion Criteria: pregnancy, cardiovascualr disease, abnormal renal function, hematologic disorder

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: early injection<br>injection of G-CSF (leukostim)5㎍/kg from day 2 of TAC chemotherapy | Drug: late leukostim<br>* injection of G-CSF (leukostim)5㎍/kg from day 5 of TAC chemotherapy<br>* Other names: 5leuko;|
| Sham Comparator: late injection<br>injection of G-CSF (leukostim)5㎍/kg from day 5 of TAC chemotherapy | Drug: early leukostim<br>* injection of G-CSF (leukostim)5㎍/kg from day 2 of TAC chemotherapy<br>* Other names: 2leuko;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| frequency of neutropenia | during the 1 cycle (21days) of ajuvant chemotherapy with TAC, record the frequency of neutropenia aftr using G-CSF (Leucostim) | Change from Baseline in neutrophil count at 21days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
G-CSF, neutropenia, TAC