Development of the Effectiveness of Rehabilitation Tools for Neurovisual Disorders in Patients With Posterior Cortical Atrophy

Study Overview
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Brief Summary
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Posterior cortical atrophy (PCA) is manifested by neuro-visual disorders that alter the spatial location of objects, their manipulation and/or recognition. Its etiology is most often neurodegenerative, with a major impact on the autonomy and mood of patients and their families. Few studies have focused on non-medication management of these disorders. The present study thus has a double objective: the development of a complete tool to work on the recognition, localization and/or manipulation of objects; and the evaluation of the effectiveness of this type of management.

Official Title
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Development and Evaluation of the Effectiveness of Rehabilitation Tools for Neurovisual Disorders in Patients With Posterior Cortical Atrophy (PCA)

Conditions
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Posterior Cortical Atrophy

Intervention / Treatment
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* Behavioral: Recognition of objects
* Behavioral: Location of objects
* Behavioral: Manipulation of objects


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age >50 years old Male or Female Patients with a diagnosis of PCA according to the criteria of Tang-Wai et al (2004) MMS>15 Voluntary, written and informed consent of the patient himself or its legal representative (guardian/curator), with oral consent of the patient in all cases Anti-Alzheimer's and psychotropic treatments stable for one month, if taken by the patient Affiliation to a social security system Exclusion Criteria: Uncorrected visual disorders with non-degenerative etiology (AV<0.5) Person under the protection of justice Pregnant women (a pregnancy test will be performed in premenopausal women)

Ages Eligible for Study
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Minimum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Recognition of objects<br>Patients will do the therapy in the following order: object location, object manipulation and object recognition | Behavioral: Recognition of objects<br>* Name of shapes / colors / images / objects Classification of shapes / colors / images / objects<br>|
| Experimental: Location of objects<br>Patients will do the therapy in the following order: object recognition, object location, and object manipulation | Behavioral: Location of objects<br>* Search for frequent/rarse targets among distractors sharing one or more characteristics with the target Hit/catch a stationary/mobile target as quickly as possible<br>|
| Experimental: Manipulation of objects<br>Patients will do the therapy in the following order: object manipulation, object recognition and object location | Behavioral: Manipulation of objects<br>* Storage of shapes/objects Use of everyday objects (pen, cutlery, etc.)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Effectiveness evaluation | Effectiveness will be evaluated a score based on success rate (from 0 to 10), reaction time and eye-recording . | At week 34 |