Evaluation, Treatment and Monitoring of Patients With a Known or Suspected Parasitic Infection

Study Overview
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Brief Summary
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The purpose of this study is to evaluate, treat and follow patients with parasitic infections. People with a known or suspected parasitic infection who are at least 1 year old may be enrolled. This study does not involve any experimental treatments. Participants will have a physical examination and laboratory tests on blood, stool, or urine. Blood samples may be collected at regular intervals, but no more than 450 ml (15 ounces) of blood will be drawn from adults, and no more than 7 ml (1-1/2 teaspoons) per kg (2.2 pounds) of body weight from children, in any 6-week period. Other tests may include x-rays, electrocardiogram (EKG), or tissue biopsy (surgical removal of a small tissue sample), depending on the individual s condition. Patients may be offered treatment or may be referred to another study that is more appropriate for the problem. Any treatment provided in this study will be according to standard medical practice for the patient s specific medical problem. Patients responses to treatment will be evaluated at regularly scheduled clinic visits. The length of time between visits and the total duration of the study for a given individual will be determined by the study doctor, based on that person s medical condition.

Detailed Description
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This study is designed as a prospective study to evaluate and treat patients with parasitic infection. Patients with known or suspected parasitic infection will be enrolled and will be evaluated for the presence of a parasitic infection. Minimal studies scheduled for each visit will include a medical history, physical examination, routine laboratory tests, and specialized diagnostic procedures for possible parasitic infections. Treatment plans will be individualized for each patient's particular condition, and the number and length of additional visits and diagnostic evaluations will vary accordingly. Specific treatment regimens will be in accordance with standard medical practice.

Official Title
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Evaluation, Treatment, and Monitoring of Patients With Known or Suspected Parasitic Infection

Conditions
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Malaria, Intestinal Worms, GI Protozoa, Echiniococcus, Strongyloides

Participation Criteria
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Eligibility Criteria
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INCLUSION CRITERIA: Age 3 or over. Access to a primary medical care provider outside of the NIH Clinical evidence suggestive of a parasitic infection EXCLUSION CRITERIA: Less than 3 years of age No evidence suggestive of a parasitic infection

Ages Eligible for Study
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Minimum Age: 3 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Diarrhea GI parasite<br>Subjects infected with a GI parasite | |
| Echinococcus<br>Subjects infected with echinococcus | |
| Intestinal worm<br>Subjects infected with parasitic intestinal worm | |
| Malaria<br>Subjects infected with malaria | |
| Parasitic infection<br>Subjects infected with a parasitic infection that is not included in the other cohorts | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The Laboratory of Parasitic Diseases has been conducting studies of the diagnosis, treatment, and pathogenesis of wide variety of parasitic infections. | Elimination of parasitic infection. | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Helminth Infection, Parasite, Known Parasitic Infection, Suspected Parasitic Infection, Natural History