A Dose Escalating Clinical Trial of the IGF-1 Receptor Inhibitor AXL1717 in Patients With Advanced Cancer

Study Overview
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Brief Summary
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A dose escalating phase Ia-b clinical trial of the IGF-1 receptor inhibitor AXL1717 in patients with advanced cancer. The objective is to study the safety and pharmacokinetics of AXL1717 and to define an appropriate Phase 2 dose for further studies. This is the first study in man. The study is not designed to show tumor response.

Official Title
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A Dose Escalating Phase Ia-b Clinical Trial of the IGF-1 Receptor Inhibitor AXL1717 in Patients With Advanced Cancer: A Prospective, Single Armed, Open Label, Dose-finding Phase Ia-b Study

Conditions
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Solid Tumors

Intervention / Treatment
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* Drug: AXL1717


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: At least 18 years of age. Histologically confirmed diagnosis of advanced solid or haematological malignancy not amenable to standard treatment. Pharmacological treatment attempt justified Preserved major organ functions, i.e: B-Leukocyte count ≥ 3.0 x 109/L B-Neutrophil count ≥ 1.5 x 109/L B-Platelet count ≥ 75 x109/L B-Haemoglobin ≥ 100 g/L (transfusions are allowed) P-Total bilirubin level ≤ 1.5 times the upper institutional limit of the normal (i.e. reference) range P-ASAT or P-ALAT ≤ 2.5 times upper institutional limit of the normal range, ≤5 times if liver metastases have been documented P-Creatinine ≤ 1.5 times upper institutional limit of the normal range Females of childbearing potential should use adequate contraception (oral or injectable contraceptives, hormone releasing intrauterine device) throughout the study period. Signed written informed consent. Exclusion Criteria: Ongoing infection or other major recent or ongoing disease that, according to the investigator, poses an unacceptable risk to the patient Known malignancy in CNS Prior anti-tumour therapy within 4 weeks from enrolment (6 weeks for nitrosurea and MitC). Pregnancy or lactation Current participation in any other interventional clinical trial Performance status > ECOG 2 after optimization of analgesics Life expectancy less than 3 months Contraindications to the investigational product, e.g. known or suspected hypersensitivity. Lack of suitability for participation in the trial, for any reason, as judged by the Investigator.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: AXL1717<br> | Drug: AXL1717<br>* Phase I study with increasing dosage and treatment duration<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To define and confirm recommended Phase 2 dose |  |  |