The Purpose of This Study is to Determine the Frequency of Colorectal Cancer in Male and Female Endurance Athletes Between the Ages of 35 and 50

Study Overview
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Brief Summary
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The purpose of this study is to determine the frequency of colorectal cancer in male and female endurance athletes between the ages of 35 and 50.

Official Title
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Measuring the Incidence of Colorectal Cancer in Young Endurance Athletes

Conditions
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Colorectal Cancer

Intervention / Treatment
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* Other: prospective observational study - screening and follow up colonoscopy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adult males and females 35-50 years of age Male and female self-reported endurance athletes, defined by at least one of the following: Run at least two races of 50 miles or more Run 5 races of 26.2 miles or more Ability to complete testing in the protocol and make study visits Able and willing to consent to protocol Exclusion Criteria: Known or suspected history of inflammatory bowel disease, familial adenomatous polyposis (FAP), or Lynch Syndrome Concomitant illness that would prevent adequate patient assessment or in the investigators' opinion pose an added risk for study participants. Anticipated poor compliance Prisoners or subjects who are involuntarily incarcerated Persons with decisional incapacity/cognitive impairment Any history or evidence of severe illness or any other condition that would make the patient, in the opinion of the investigator unsuitable for the study Subject is involved with a worker's compensation, personal injury, or other legal matters related to their health Subject is enrolled in a separate interventional clinical trial

Ages Eligible for Study
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Minimum Age: 35 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: prospective observational study - screening and follow up colonoscopy|Involves two visits and a colonoscopy. The first visit will be prior to the colonoscopy. 4-35 days after the colonoscopy, there will be a one time appointment to go over the results of the colonoscopy.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| rate of young endurance athletes that have adenomatous polyps | The rate of adenomatous polyps and colorectal cancer will be estimated with their 95% confidence intervals using the exact binomial method | 36 months | 
| rate of young endurance athletes that have colorectal cancer on screening colonoscopies. | The rate of adenomatous polyps and colorectal cancer will be estimated with their 95% confidence intervals using the exact binomial method | 36 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| comparison of the rate of young endurance athletes that have adenomatous polyps with that of the historical controls (those in the average risk group) | Fisher's Exact test will be used to compare the rates of adenomatous polyps and colorectal cancer between the young endurance athletes and that of the historical controls. | 36 months | 
| Comparison of the rate of young endurance athletes that have colorectal cancer on screening colonoscopies with that of the historical controls (those in the average risk group). | Fisher's Exact test will be used to compare the rates of adenomatous polyps and colorectal cancer between the young endurance athletes and that of the historical controls. | 36 months |