Anti-mullerian Hormone Levels in Healthy Females

Study Overview
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Brief Summary
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The purpose of this study is to have a better understanding of the normal blood levels of AMH in females from 0-18 years of age and how the blood AMH levels correspond to a female's reproductive development.

Detailed Description
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Anti-mullerian hormone (AMH) is a chemical in the body that is found in the blood that can estimate the ability of a female to have her own children. It is widely used in adult female cancer patients to predict the onset of menopause and/or the inability to have children that can be associated with chemotherapy and/or radiation treatment. Normal blood levels of AMH are better understood in adults than in children and adolescents. The purpose of this study is to have a better understanding of the normal blood levels of AMH in females from 0-18 years of age and how the blood AMH levels correspond to a female's reproductive development. With a better understanding of normal AMH levels in children, we may be able to better assess a girl's risk of not being able to have children if she is a cancer patient, and may be able to offer her and her family options to increase the chances of having her own children.

Official Title
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Anti-mullerian Hormone Levels in Healthy Females

Conditions
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Healthy

Intervention / Treatment
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* Diagnostic Test: Blood sample collection


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Pre- and post-pubertal females Ages 0-18 years old Tanner Stage I- V Undergoing routine outpatient surgical procedure Hernia repair (inguinal, umbilical, epigastric) Excision of benign mass laparoscopic cholecystectomy Exclusion Criteria: Previous diagnosis of an illness associated with premature ovarian failure (Turner's syndrome, Fragile X permutation carrier) or endocrine disorder associated with irregular menstrual cycles (Cushing's disease, poorly-controlled Thyroid disease, hyperprolactinemia, polycystic ovary syndrome, and congenital adrenal hyperplasia) or insulin-dependent diabetes mellitus or autoimmune disorders Previous diagnosis of any malignancy or any history of systemic/local chemotherapy, radiation therapy, or stem-cell transplant. Previous surgical excision of one ovary or both ovaries Pregnant females All inpatient surgical patients Undergoing non-routine outpatient surgical procedures Central venous catheter placement Supprelin insertion/removal Breast mass excision Gastrostomy tube insertion

Ages Eligible for Study
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Maximum Age: 18 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Blood sample collection<br>Blood samples are collected for diagnostically assessing how the blood AMH levels correspond to a female's reproductive development | Diagnostic Test: Blood sample collection<br>* Blood samples are collected for diagnostically assessing how the blood AMH levels correspond to a female's reproductive development<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Anti-mullerian Hormone Levels in Healthy Females | The primary outcome measure is to get a better understanding of the normal AMH levels in children (girls aged 0-18 years) in order to better assess a girl's risk of not being able to have children if she is a cancer patient, and in offering her and her family options to increase the chances of having her own children | 3 Years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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AMH