Genetic Analysis of Childhood Obesity

Study Overview
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Brief Summary
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Identify news genetic causes of different type of obesity (syndromic, familial or isolated obesity) by highlighting new mutations or new implied genes

Official Title
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Genetic Analysis of Childhood Obesity

Conditions
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Obesity

Intervention / Treatment
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* Other: Identification of genetic causes of obesity


Participation Criteria
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Eligibility Criteria
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Inclusion criteria: BMI > curve of IOTF 30 (International Obesity Task Force) Age: between 6 months old and 18 years old Child presenting syndromic, isolated or familial obesity. Exclusion Criteria: Common obesity Impossibility for blood sampling Impossibility to receive information Participation refusal of one of the parents Refusal to sign the informed consent Neither Healthcare coverage nor insurance

Ages Eligible for Study
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Minimum Age: 6 Months
Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Syndromic obesity<br>Identification of genetic causes of obesity | |
| Familial obesity<br>Identification of genetic causes of obesity | Other: Identification of genetic causes of obesity<br>* A blood test will be performed to the child and his/her parents with the aim of identifying genetic causes of obesity. Different analysis will be as follows: caryotypes, Raindance, whole exome, in order to find potential mutations or new genes associated to this condition<br>|
| Isolated obesity<br>Identification of genetic causes of obesity | Other: Identification of genetic causes of obesity<br>* A blood test will be performed to the child and his/her parents with the aim of identifying genetic causes of obesity. Different analysis will be as follows: caryotypes, Raindance, whole exome, in order to find potential mutations or new genes associated to this condition<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To identify the number of mutations or genes involved in genetic causes of Child obesity | Children with obesity and their parents will be recruited to establish genetic causes of obesity. This will allow perform genetic analysis using new approaches for the identification of involved mutations or new candidate genes | first day of enrollement | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To identify the number of mutations in the population |  | first day of enrollement | 
| To identify the number of new mutations present in the children's DNA and absent from their parents' genomes | This approach will allow the identification of specific mutations that are present only in affected children but not in their parents | first day of enrollement | 
| To determine number of phenotypes associated to the child obesity genotype |  | first day of enrollement | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Childhood Obesity, Genetics