Discriminant Ability of the Shock Index, Modified Shock Index, and Reverse Shock Index Multiplied by the Glasgow Coma Scale on Mortality in Adult Trauma Patients: A PATOS Study

Study Overview
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Brief Summary
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We evaluated a cohort of adult trauma patients transported to emergency departments. The first vital signs were used to calculate the SI, MSI, and rSIG. The areas under the receiver operating characteristic curves (AUROCs) and test results were used to compare the discriminant performance of the indices on short-term mortality and poor functional outcome. A subgroup analysis of geriatric patients, traumatic brain injury, penetrating injury, and non-penetrating injury was performed.

Official Title
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Discriminant Ability of the Shock Index, Modified Shock Index, and Reverse Shock Index Multiplied by the Glasgow Coma Scale on Mortality in Adult Trauma Patients: A PATOS Study

Conditions
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Trauma, Shock, Traumatic, Morality

Intervention / Treatment
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* Other: Observational


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adult patients (≥18 years) EMS-transported from January 2016 to December 2020 Exclusion Criteria: Patients with missing entries of age, sex, triage, SBP, DBP, HR, or GCS were excluded. Entries with missing records of in-hospital mortality or 30-day mortality were excluded from the short-term mortality cohort analyses. Patients without a Modified Rankin Scale (MRS) record at discharge were excluded from the functional outcome cohort analyses.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Mortality group<br>Patients encountered in-hospital mortality or 30-day mortality | Other: Observational<br>* Observational<br>|
| Survival group<br>Patients did not encounter in-hospital mortality or 30-day mortality | Other: Observational<br>* Observational<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Discriminant power of SI, MSI, and rSIG on short-term mortality for adult traumatic patients | AUROC in associated with short-term mortality with SI, MSI, rSIG | 30 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Discriminant power of SI, MSI, and rSIG on functional outcome for adult traumatic patients | AUROC in associated with functional outcome with SI, MSI, rSIG | We defined no symptoms, no significant disability, slight disability, and moderate disability (MRS 0-3) as favorable functional outcomes and moderately severe disability, severe disability, and death (MRS 4-6) as poor functional outcomes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Shock index(SI), Modified Shock Index (MSI), Reverse Shock Index Multiplied by the Glasgow Coma Scale (rSIG), Mortality, Pan-Asian Trauma Outcomes Study (PATOS)