Renal Doppler Ultrasound in Early Detection of Acute Kidney Injury in Critically Ill Patients

Study Overview
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Brief Summary
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Acute kidney injury is a common complication of critical illness and is associated with high morbidity and mortality .Acute kidney injury is a syndrome that is characterized by a rapid decline in renal function and urine output, resulting in retention of waste products such as urea, nitrogen, and serum creatinine. Life-threatening consequences include volume overload, hyperkalaemia, and metabolic acidosis . In its severe form, Acute kidney injury requires renal replacement therapy, which is applied in 5±13% of Intensive Care Unit patients

Detailed Description
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The incidence of Acute kidney injury in intensive care unit patients is rising due to the population age increasing, more comorbidities, and a higher prevalence of risk factors. Improved Intensive Care Unit management has, however, significantly diminished morbidity and the mortality of patients who develop Acute kidney injury I. Despite an increase in the number and severity of comorbidities, in-hospital mortality has declined, but the incidence of Acute kidney injury ,and Acute kidney injury requiring renal replacement therapy has increased over time . There is still some dispute over the characterization of the different types of Acute kidney injury. Classically there are three types of Acute kidney injury: pre-renal, intrinsic renal, and post-renal failure. These are characterized as decreased renal blood flow (in 40-70% of the patients), direct (intrinsic) renal parenchymal damage (in 10-50% of the patients), and obstruction of urine flow which is less common in the ICU (10%), respectively.. In critically ill patients, sepsis and acute kidney injury are very common diseases and are associated with increased hospitalization and elevated in-hospital mortality rates Acute kidney injury is a dynamic process that evolves from an early reversible condition to an established disease and leads to sustained renal impairment, cell death ,and delayed renal recovery .Consequently, prompt resuscitation of the circulation and optimal perfusion pressure are the primary therapies for critically ill patients with Acute kidney injury. These methods are based principally on the appropriate management of intravenous fluid replacement and vasopressor administration under strict hemodynamic monitoring . Mechanisms of Acute kidney injury comprise renal hypo-perfusion, intra-renal vasoconstriction, inflammation,oxidative stress and nephrotoxicity .An important pathophysiological pathway includes intra renal vasoconstriction and endothelial damage of the microvessels, leading to impaired macro- and microvascular flow, which further aggravates ischemia . Renal vasoconstriction is an early manifestation of Acute kidney injury. More specifically, ultrasound imaging of the renal arteries can be instrumental in the early detection of Acute kidney injury. Indeed, renal blood flow is decreased at a nearly stage during acute tubular necrosis as a consequence of protracted intra renal vasoconstriction. The renal resistive index , which is used for assessing arterial pulsatility, was shown to correlate with renal vascular resistance . Renal Doppler ultrasound can measure the renal resistive index , a sonographic index that reflects alterations in blood flow profile of the intrarenal arcuate or interlobar arteries. It reflects the relation between the decline in speed loss of flow (flow velocity) between the peak of systole and the end of diastole in (renal) blood vessels: RRI = (peak systolic velocity _end diastolic velocity)/(peak systolic velocity). Normal values are reported between 0.60 and 0.70 with the difference between both kidneys mostly being less than 5% . The Doppler renal resistive index has been used for years in a variety of clinical settings . Doppler imaging identifies changes in blood flow at the micro-vascular level. Evaluation of the vascular impedance at different sites of the renal parenchyma could provide useful diagnostic and prognostic information. An increase in renal vascular resistance may be an early sensitive sign of hemodynamic deterioration, even in seemingly stable patients. Measuring flow resistance in the renal circulation, Renal resistive Index (RRI), could become part of vital organ function assessment using Doppler ultrasound. An increased Doppler Renal resistive Index is suggested to not only reflect changes in intra renal perfusion, but also in systemic hemodynamics . Renal resistive index (RI), determined by Doppler ultrasonography, directly reveals and quantifies modifications in renal vascular resistance . Aim of the work The aim is to Determine if the resistive Renal Index on ICU admission patients predicts the development of Acute kidney injury during the first week. Determine whether resistive Renal Index is related to the severity of Acute kidney injury or not. Patients and Methods 80 patients of critically ill patients including acute ischaemic insults, patients presenting with septicaemia, hypertension, respiratory failure, coagulation/ haemorrhagic disorders, shock, and liver disease and shock. This study will be performed in the 24-bed mixed medical and surgical intensive care unit of the Assiut University Hospital. Sample size calculations will be based on the assumption that patients not developing Acute kidney injury would have an RRI of 0.72 and patients developing Acute kidney injury would have an Acute kidney injury of 0.79 with a standard deviation of 0.11. These calculations were based on the results of other previous studies that reported median values for Acute kidney injury and no Acute kidney injury AKI was defined according to the Kidney Disease Improving Global Outcome (KDIGO) classification using both creatinine and urine output criteria [20] KDIGO takes changes in creatinine within 48 hours, or a decline in the glomerular filtration rate (GFR) over 7 days, into account. AKI is defined as an increase in sCreat ≥0.3 mg/dL within 48 hours, or an increase in sCreat ≥1.5-times baseline, which is known or presumed to have occurred within the prior 7 days, or a Urine Out put of <0.5 mL/kg/h for 6 hours Laboratory tests: Complete blood count Kidney function Electrolytes including sodium,potassium, calcium,Phosphorus and uric acid Urine analysis 5-24 hrs sodium in urine Radiological test: Doppler of both renal arteries with abdominal ultrasound. Renal resistive index was measured with ultrasound-Doppler

Official Title
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Role of Renal Doppler Ultrasound in Early Detection of Acute Kidney Injury in Critically Ill Patients

Conditions
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Acute Kidney Injury

Intervention / Treatment
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* Device: renal doppler ultrasound


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age >18 years ICU admission within 24 hours Exclusion Criteria: Poor abdominal echogenicity Severe acute or chronic renal insufficiency Dialysis dependency, renal transplantation Renal artery stenosis, congenital renal diseases ,renal tumor Suicidal attempt Pregnancy

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: renal doppler ultrasound|renal doppler ultrasound measuring renal resistive index|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Role of Doppler Renal resistative index in early Prediction of acute kidney injury in critically ill patients | Renal resistive index was measured with ultrasound-Doppler using atransparietal 5MHz pulsed-wave Doppler probe. After visualizing the kidney in ultrasound mode and checking for renal abnormalities, an arcuate or interlobar artery will be localized and three successive Doppler measurements at different positions in the kidney (high, middle and low) will be performed, 3 times in each kidney. So a total number of 9 RRI values will be obtained in each kidney.The median value of each section will be used and the 3 median values of each kidney will be averaged. patients developing AKI would have an AKI of 0.79 with a standard deviation of 0.11 | at one day of the study |