Blood Pressure Changes During Moderate Intensity Strength Training in Aortic Stent-graft Patients

Study Overview
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Brief Summary
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Patients with an aortic stent graft are recommended to do muscle strengthening exercise as part of their rehabilitation. But, as excess blood pressure pose a risk to the integrity of the stent graft, high intensity muscle strengthening exercise may potentially be detrimental, and hence moderate intensity muscle strengthening is recommended. However, the blood pressure changes during moderate intensity strengthening exercises are unknown, and this study aims to quantify these among patients and compare them to those of healthy volunteers. Purpose: The purpose of this study is to investigate the increase in blood pressure during quadriceps muscle strength training in patients with aortic stent graft. Methods: Patients with aortic stent graft will be included. The participants are investigated once. During the investigation, the blood pressure increase during a single strength training exercise (leg press) is measured. The strength training exercise is done at 60% of maximal strength (moderate intensity) corresponding to 15 Repitition Maximum (RM) (a load that can be lifted exactly 15 times).

Official Title
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Peak Systolic Blood Pressure in Heart Patients With Aortic Stent-graft During Moderate Intensity Strength Training: A Descriptive Intervention Study

Conditions
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Aortic Stent Graft

Intervention / Treatment
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* Other: Moderate Intensity Muscle Strengthening


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria patients: Adults (+18y) with aortic stent graft following aortic dissection or aneurism Minimum 8 weeks post surgery Strengthening exercise approved by treating cardiologist Able to perform the exercise Exclusion Criteria patients: Lack of ability to read, speak or understand instructions in Danish or English Other unspecified heart disease Inclusion Criteria healthy volunteers: Adults (+18y) In good health (self report) Exclusion Criteria healthy volunteers: • Lack of ability to read, speak or understand instructions in Danish or English

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Aortic stent graft patients<br>Patients who have received an aortic stent graft who will perform one session of moderate intensity muscle strengthening during which blood pressure will be measured. | Other: Moderate Intensity Muscle Strengthening<br>* 1 session of lower extremity muscle strengthening at moderate intensity (60% of estimated maximal muscle strength). The exercise is performed on one single day.<br>|
| Experimental: Healthy volunteers<br>Healthy volunteers in general good health with no history of heart disease who will perform one session of moderate intensity muscle strengthening during which blood pressure will be measured. | Other: Moderate Intensity Muscle Strengthening<br>* 1 session of lower extremity muscle strengthening at moderate intensity (60% of estimated maximal muscle strength). The exercise is performed on one single day.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Peak systolic pressure during a single lower extremity muscle strengthening exercise | Blood pressure is measured continuously using a finger clamp measurement device (Nexfin) | 5 minutes: 15 repetitions of leg press muscle strength exercise. |