AGARIC Case Control Study

Study Overview
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Brief Summary
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The aim of the study is to establish the existence of a relationship between the dietary intake of polyunsaturated fatty acids (PUFA) and the risk of colorectal cancer in humans, using 2 reliable and complementary biomarkers: the fatty acid-composition of lipids of the abdominal subcutaneous adipose tissue and the fatty acid composition of erythrocyte phospholipids.

Official Title
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Consumption of Fatty Acids, Metabolism of Adipose Tissue and Risk of Colorectal Cancer: AGARIC Case Control Study

Conditions
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First Recently-diagnosed Colorectal Cancer

Intervention / Treatment
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* Other: Blood sample
* Other: tissue samples from abdominal subcutaneous adipose


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: CASES Patients aged ≥ 45 years with a first recently-diagnosed colorectal cancer due to undergo elective surgical resection with curative intent (in practice, stage I, II, III or IV if there was only one hepatic nodule that was resected with curative intent) in one of the 5 following digestive surgery units: CHU de Dijon, CHU de Nancy, CHU de Strasbourg, CHU de Reims et CHU and Besançon. who have given their informed consent CONTROLS Patients aged ≥ 45 years due to undergo surgery for a benign abdominal disease (sigmoid diverticulitis, appendectomy, hiatal hernia …) matched for abdominal site with cases for age (± 3 years), sex and hospital Who have given their informed consent Exclusion Criteria: CASES pre-operative anticancer treatment (chemo or radiotherapy) existence of visceral metastases except a single hepatic nodule resected with curative intent familial adenomatous polyposis and HNPCC syndrome (when suspected: inclusion after complementary tumor phenotype study: screening for microsatellite instability and/or immunohistochemistry study of the expression of DNA mismatch repair proteins. known inflammatory disease of the intestine (ulcerative colitis, Crohn's disease) personal history (recent or not) of colorectal cancer emergency treatment for the presenting complication (perforation, occlusion…) significant modification in dietary habits during the previous three months other evolving neoplastic disease psychic state incompatible with understanding the modalities and the aims of the study (notably patients under guardianship) pregnant or breast-feeding women CONTROLS personal history of cancer or adenomatous colorectal polyps, emergency intervention known inflammatory disease of the intestine (ulcerative colitis, Crohn's disease) personal history (recent or not) of colorectal cancer emergency treatment for the presenting complication (perforation, occlusion…) significant modification in dietary habits during the previous three months evolving neoplastic disease psychic state incompatible with understanding the modalities and the aims of the study (notably patients under guardianship) pregnant or breast-feeding women

Ages Eligible for Study
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Minimum Age: 45 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Design Details

Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Cases<br> | Other: Blood sample<br> <br> Other: tissue samples from abdominal subcutaneous adipose<br> <br> |
| Other: controls<br> | Other: Blood sample<br> <br> Other: tissue samples from abdominal subcutaneous adipose<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measure of polyunsaturated fatty acids in adipose tissue lipids. |  | baselines |