Comparison of Operated Ruptured and Non-ruptured Endometriomas

Study Overview
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Brief Summary
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Ruptured endometrioma cases were compared with unruptured endometrioma cases.

Detailed Description
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This study aims to compare the findings in patients who had surgery for ruptured endometrioma with the patients who had an unruptured endometrioma. This study was conducted at Republic of Turkey Ministry of Health, Health Science University Etlik Zübeyde Hanım Gynecology Training and Research Hospital Infertility Clinic and all patients who were operated for endometrioma and had a histopathology report confirming the presence of endometrioma between January 2014 and December 2020 were included. In this study, demographic characteristics, intraoperative findings, laboratory values and follow-up recommendations of two groups compared. The patients' age, presence of sexual activity and/or infertility, gravidity, parity, abortion, history of ectopic pregnancy, accompanying systemic disease, previous operations, drug use, and symptoms were recorded. Preoperative and postoperative complete blood count, Cancer antigen 125 (CA 125), Cancer antigen 19-9 (CA19-9), Cancer antigen 15-3 (CA 15-3), Carcinoembryonic antigen (CEA), alpha fetoprotein (AFP), anti mullerian hormone (AMH), fibrinogen, C-reactive protein (CRP) values of the patients were obtained. Patient files, operation notes and laboratory values of the electronic recording system database and the two groups were compared.

Official Title
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Comparison of Inflammatory Parameters in Operated Ruptured and Non-ruptured Endometriomas

Conditions
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Endometrioma, Ruptured Endometrioma, Endometriosis Ovary

Intervention / Treatment
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* Procedure: Laparoscopy/Laparotomy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All patients who were operated on in Republic of Turkey Ministry of Health, Health Science University Etlik Zübeyde Hanım Gynecology Training and Research Hospital Infertility Clinic, whose histopathological diagnosis was confirmed as endometrioma, and who did not meet the exclusion criteria, were included in the study. Exclusion Criteria: Patients who were operated with a prediagnosis of endometrioma and whose pathological diagnosis was different Patients with smoking, alcohol, substance abuse Patients receiving pelvic radiotherapy/chemotherapy Patients with suspected or confirmed malignancies

Ages Eligible for Study
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Minimum Age: 16 Years
Maximum Age: 48 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Operated Non-Ruptured Endometrioma Group<br>It consists of patients who were found to have endometrioma in their clinical follow-ups and decided to operate as a result of the evaluations. The patients were operated under elective conditions. | Procedure: Laparoscopy/Laparotomy<br>* All patients included in the study were operated patients.<br>|
| Operated Ruptured Endometrioma Group<br>Rupture of endometrioma, which is a rare gynecological emergency. This group consists of endometrioma patients requiring urgent/subacute operation such as acute abdominal pain, hemodynamic instability, intra-abdominal bleeding. The patients were operated after completing the necessary preparations | Procedure: Laparoscopy/Laparotomy<br>* All patients included in the study were operated patients.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pre-interventional Comparison of inflammatory parameters | Neutrophil/Lymphocyte ratio (NLR), Platelet/Lymphocyte ratio (PLR), Monocyte/Lymphocyte ratio (MLR) were compared between two groups in the preoperative period | Blood samples were taken from the patients before the surgery | 
| Comparison of inflammatory parameters after surgery | Neutrophil/Lymphocyte ratio (NLR), Platelet/Lymphocyte ratio (PLR), Monocyte/Lymphocyte ratio (MLR) were compared between two groups in the postoperative period | Blood samples were taken from the patients in the first postoperative day. | 
| Pre-interventional Comparison of tumor markers | Cancer antigens; CA125, CA19-9 and CA 15-3 were compared between two groups in the preoperative period | Blood samples were taken from the patients before the surgery | 
| Comparison of tumor markers after surgery | Cancer antigens; CA125, CA19-9 and CA 15-3 were compared between two groups in the postoperative period | Blood samples were taken from the patients after the surgery up to 24 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sexual activity | The existence of sexual activity in each study group was questioned. | Before surgery | 
| Infertility | The existence of infertility in each study group was questioned. | Before surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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endometrioma, rupture, endometriosis