Paclitaxel in Patients With Metastatic or Advanced Gastrointestinal Stromal Tumors (GIST) After Failure to Imatinib and Sunitinib

Study Overview
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Brief Summary
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With discovery of KIT mutations and the advent of KIT tyrosine kinase inhibitor imatinib (GlivecTM, Novartis), there has been substantial improvement in overall survival in patients with advanced and/or metastatic gastrointestinal tumors (GIST). Recently, sunitinib (SuteneTM, Pfizer) showed activity as second-line therapy in GIST patients after failure with imatinib. However, virtually all patients will eventually progress or become intolerable after the first-line imatinib and the second-line sunitinib.

Official Title
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A Trial of Paclitaxel in Patients With Metastatic or Advanced Gastrointestinal Stromal Tumors (GIST) After Failure to Imatinib and Sunitinib

Conditions
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Gastrointestinal Stromal Tumors

Intervention / Treatment
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* Drug: Paclitaxel


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 20 years or older Histologically confirmed metastatic and/or advanced GIST with CD117(cluster of differentiation 117)(+), DOG-1(+), or mutation in KIT or PDGFRα gene(Platelet Derived Growth Factor Receptor) Failed (progressed and/or intolerable) after prior treatments for GIST, including at least both imatinib and sunitinib . Eastern Cooperative Oncology Group performance status of 0 2 Resolution of all toxic effects of prior treatments to grade 0 or 1 by NCI-Common Toxicity Criteria for Adverse Effects version 3.0 At least one measurable lesion as defined by Response Evaluation Criteria In Solid Tumors version 1.0 Adequate bone marrow, hepatic, renal, and other organ functions Neutrophil > 1,500/mm3 Platelet > 100,000/mm3 Hemoglobin > 8.0 g/dL Total bilirubin < 1.5 x upper limit of normal (ULN) Aspartate aminotransferase /Alanine transferase< 2.5 x ULN (or < 5 x ULM in case of liver metastases) Creatinine < 1.5 x ULN Life expectancy > 12 weeks Washout period of previous TKIs(Tyrosine Kinase Inhibitor) or chemotherapy for more than 4 times the half life. Provision of a signed written informed consent Exclusion Criteria: Women of child-bearing potential who are pregnant or breast feeding or adults of reproductive potential not employing an effective method of birth control. have the presence of cardiac disease,including a myocardial infarction within 6 months prior to study entry,Clinically significant cardiac disease (New York Heart Association, Class III or IV) or severe unstable angina pectoris, stroke or transient ischemic attack, Arrhythmia in need of treatment Uncontrolled infection Diabetes mellitus (insulin dependent or independent disease, requiring chronic medication) with signs of clinically significant peripheral vascular disease. Acute and chronic liver disease and all chronic liver impairment.(Patients with stable and chronic viral hepatitis are eligible are acceptable) Uncontrolled gastrointestinal toxicities with toxicity greater than NCI Common Toxicity Criteria for Adverse Effects grade 2 Other severe, acute, or chronic medical or psychiatric condition or laboratory abnormality. The patient experienced any bleeding episode considered life-threatening, or any grade 3 or 4 bleeding event. Major surgery ≤ 28 days prior to starting study drug or who have not recovered from side effects of such therapy. Known diagnosis of HIV infection . History of another primary malignancy that is currently clinically significant or currently requires active intervention. Patients with brain metastases as assessed by radiologic imaging Alcohol or substance abuse disorder.

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Paclitaxel<br>paclitaxel 80mg/m2/day on a Cycle1Day1, Cycle1Day8,Cycle1Day15 off 1 week schedule | Drug: Paclitaxel<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Disease control rate |  | Up to 3 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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single-center, prospective, single-arm, open-label, phase II