Effect of Sleep Apnea on Blood Pressure Control and Outcome Early After Subarachnoid Hemorrhage

Study Overview
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Brief Summary
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In this observational study patients with subarachnoid hemorrhage (SAH) will be screened for sleep apnea (SA) to investigate if SA is associated with impaired blood pressure control and worse clinical outcome early after SAH.

Detailed Description
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Patients admitted with non-traumatic SAH will be consented and screened for sleep apnea within 48 hours after hospital admission. Blood pressure and clinical outcome will be monitored throughout ICU treatment and hospital stay, respectively. Diagnosis of sleep apnea will be confirmed on follow-up 3-6 month after SAH by sleep apnea screening (portable cardiorespiratory monitoring and out-of-center polysomnography, respectively).

Official Title
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Effect of Sleep Apnea on Blood Pressure Control and Outcome Early After Subarachnoid Hemorrhage

Conditions
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Subarachnoid Hemorrhage, Sleep Apnea

Intervention / Treatment
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* Device: Sleep Apnea Screening (Out of Center Polysomnography Device)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Subarachnoid Hemorrhage (Hunt & Hess 1 to 4) > 18 years of age Ability to consent for study of healthcare proxy able to confirm patient will to participate Exclusion Criteria: Stoke within 3 month prior to admission Intubation prior or within 24 hours after admission no healthcare proxy

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with Sleep Apnea<br>Patients with increased apnea-hypopnea-index (>5/h) | Device: Sleep Apnea Screening (Out of Center Polysomnography Device)<br> <br> |
| Patients without Sleep Apnea<br>Patients with normal apnea-hypopnea-index (5/h and below) | Device: Sleep Apnea Screening (Out of Center Polysomnography Device)<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time to blood pressure target | The time required to reach blood pressure target as defined by care provider. | Within 10 Days of hospital admission with subarachnoid hemorrhage | 
| Medication needed to achieve blood pressure target | Blood pressure medication required to reach blood pressure target as defined by care provider. | Within 10 Days of hospital admission with subarachnoid hemorrhage | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in modified ranking scale (mRS) from baseline to discharge and follow-up visit, respectively. | Change in modified ranking scale at hospital discharge and at follow-up (3-6 month after SAH) will be assessed and compared between patients with and without sleep apnea. The change from baseline to discharge/follow-up will be compared between groups. | 3 to 6 Month after SAH | 
| Change in NIH stroke scale score (NIHSS) from admission to discharge and follow-up visit, respectively. | Neurological outcome measured as score in NIHSS at hospital discharge and at follow-up (3-6 month after SAH) will be assessed and compared between patients with and without sleep apnea. The change from baseline to discharge/follow-up will be compared between groups. | 3 to 6 Month after SAH | 
| Barthel Index at discharge at follow-up visit, respectively. | Impairment of daily living (score in Barthel index) at discharge and at follow-up visit (3 to 6 month after SAH) will be assessed. The change from baseline to discharge/follow-up will be compared between groups. | 3 to 6 Month after SAH | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Subarachnoid hemorrhage, Sleep Apnea