The A-LIST WMM Insights Series

Study Overview
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Brief Summary
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The main purpose of the Study is to develop an understanding over time and through multiple research projects, including surveys, interviews, online focus groups, and other primary research methodologies (A-LIST Research Projects) on what matters most to individuals concerned about brain health and those with and/or affected by Alzheimer's disease and other dementias, including caregivers.

Detailed Description
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To do this, UsAgainstAlzheimer's will identify and engage individuals who want to focus on brain health; individuals who are worried about their cognition; individuals who perceive themselves to be at risk for Alzheimer's disease (AD); individuals who may be at risk for AD due to self-identified confirmation of underlying disease pathology; individuals who self-identify as having a diagnosis of mild cognitive impairment (MCI) or of AD or another dementia; and those who self-identify as current or former caregivers of patients with Alzheimer's disease or another dementia to participate in the A-LIST Research Projects. Such participants will either already be - or will be invited to become - members of the A-LIST cohort, an online cohort of individuals ready and willing to engage in A-LIST WMM Insights Series (A-LIST members). The A-LIST WMM Insights Series will enlist participants to offer insights into a range of issues relevant to Alzheimer's, including as examples issues pertinent to clinical trial design, regulatory submissions, other research strategies, payer value determinations, and care and services research. The A-LIST WMM Insights Series may seek information that in some instances will be marketing research or other research exempt from IRB oversight. However, when an individual A-LIST Research Project constitutes human subjects research consistent with governing law, IRB approval will be sought and obtained. Where questions exist whether an individual A-LIST Research Project constitutes human subject research, IRB determination will be solicited.

Official Title
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A-LIST What Matters Most Insights Series

Conditions
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Alzheimer Disease, Dementia, Mild Cognitive Impairment

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: To be eligible to participate in the Study, an individual must meet all of the following criteria: Age 18 years or older. United States, Canada resident. Self-report of cognitive difficulties, caregiver status or interest in brain health. Have indicated willingness to participate by selecting I Agree option when joining the A-LIST. Additionally, will have clicked on link - invitation to take a specific survey Able to speak, read, and understand English. Exclusion Criteria: An individual who meets any of the following criteria will be excluded from participation in this Study: 1. Unable to comply with the Study requirements.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 100 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Phenotypical Characteristics of Patients and Caregivers | Online monthly surveys capture the burden and unmet needs for patients and caregivers of individuals with or at risk for Alzheimer's disease, other dementias, and mild cognitive impairment; also recruiting individuals interested in brain health. | 3 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Alzheimer, Dementia, Cognitive, Cognition, Brain health