Amyloïd Load in Elderly Population: Effect of Cognitive Reserve

Study Overview
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Brief Summary
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This research aim to explore relationships between the presence of amyloid burden and cognitive performance, and its modulation by educational level. For this purpose we will combine Positron emission tomography (PET) imaging and neuropsychological assessment acquired on 3 groups of subjects, from two population-based cohorts 3C and AMIMage The first group includes cognitively intact participants who will serve as controls, the second group, subjects with mild cognitive impairments without memory complaint and the third, subjects with both mild cognitive impairments and memory complaint.

Detailed Description
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Influence of educational level on the relationship between disease-specific lesion development and cognitive function will be assessed, as measured by amyloid PET imaging and a battery of neuropsychological tests at the very early stages of the disease, comparatively to age-matched controls. In addition, this project will explore the influence of cognitive complaint. It's assumed that 1) the amyloid-PET measures in age-matched controls and subjects from the two cohorts will correlate with cognitive performances; 2) the amyloid burden will be higher in high- than in low-educated subjects with similar cognitive impairment; and 3) similarly the amyloid burden will be higher in subjects with cognitive complaint compared to subjects without cognitive complaint. Considering a longer term, the clinical follow-up of study participants will allow to investigate the prognosis value of amyloid load for improving the prediction of cognitive decline and disease progression.

Official Title
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Amyloïd Load in Elderly Population: Effect of Cognitive Reserve

Conditions
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Plaque, Amyloid, Cognitive Deficits

Intervention / Treatment
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* Other: PET
* Other: MRI
* Other: neuropsychological tests


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Participation in the AMI or 3C cohorts Group 1- Controls MMSE > 24 or > 26 for low and high levels of education, respectively. Without memory impairment (for episodic memory) on the Free and Cued Selective Reminding Test RL/RI-16 items (FCSRT), free recall > 22 and total recall >42, according to the thresholds for population-based studies Without memory complaint Without dementia Group 2- Cognitively-impaired subjects without dementia and without memory complaints Mini Mental State Evaluation (MMSE) < 24 or < 26 for low and high levels of education, respectively With memory impairments according to the RL/RI-16 test (free recall≤22 and/or total recall ≤42), according to the thresholds for population-based studies defined by Auriacombe et al., 2010. Without memory complaint Without dementia Group 3- Cognitively-impaired subjects without dementia and with memory complaints MMSE < 24 or < 26 for low and high levels of education, respectively With memory impairments according to the RL/RI-16 test (same thresholds as above) With memory complaint Without dementia Exclusion Criteria: Being left handed Presence of dementia (based on the clinical diagnosis) Presence of stroke Presence of Parkinson's disease Presence of a counter-indication for MRI Presence of a counter-indication for PET Scan with [18F]-Flutemetamol Presence of any health problem preventing travel to the imaging service of the University Hospital Being under the legal guardianship of another person or being unable to provide consent to participate Pregnant or breastfeeding woman

Ages Eligible for Study
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Minimum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Group 1<br>Controls | Other: PET<br>* PET Scan with [18F]-Flutemetamol<br>Other: MRI<br> <br> Other: neuropsychological tests<br> <br> |
| Experimental: Group 2<br>Cognitively-impaired subjects without dementia and without memory | Other: PET<br>* PET Scan with [18F]-Flutemetamol<br>Other: MRI<br> <br> Other: neuropsychological tests<br> <br> |
| Experimental: Group 3<br>Cognitively-impaired subjects without dementia and with memory | Other: PET<br>* PET Scan with [18F]-Flutemetamol<br>Other: MRI<br> <br> Other: neuropsychological tests<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Amyloid load |  | at inclusion (day 0) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Neuropsychological scores |  | At inclusion (Day 0) | 
| Educational level |  | At inclusion (Day 0) | 
| Memory complaint |  | At inclusion (Day 0) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Alzheimer disease, amyloid load, educational level, cognitive performances