BOO and DU and Their Clinical and Urodynamic Findings in Women With ≥Stage II Cystocele

Study Overview
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Brief Summary
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Prevalence rates of bladder outlet obstruction (BOO) and detrusor underactivity (DU) and their related clinical and urodynamic findings in women with ≥ pelvic organ prolapse quantification stage II cystocele are important for clinical consultation. Thus, the aim of this study was to elucidate the above findings and between-group associations.

Detailed Description
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Between November 2011 and January 2017, medical records of all women with ≥stage II cystocele who underwent 20 min pad testing and urodynamic studies in a medical center were reviewed. Only those with complete data of maximum flow rate (Qmax) and detrusor pressure at maximum flow rate (PdetQmax) were enrolled. ANOVA test and post-hoc testing with bonferroni's correction were used for statistical analysis. Woman were defined as having DU when Qmax was <12 mL/s and PdetQmax was <10 cmH2O, and were defined as having BOO when Qmax was <12 mL/s and PdetQmax was ≥25 cmH2O with sustained detrusor contraction during voiding cystometry.

Official Title
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Prevalence Rates of Bladder Outlet Obstruction and Detrusor Underactivity and Their Clinical and Urodynamic Findings in Women With ≥Stage II Cystocele

Conditions
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Bladder Outlet Obstruction and Detrusor Underactivity in Women With Severe Cystocele

Intervention / Treatment
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* Diagnostic Test: Pad test


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age > 20y/o Cystocele > stage II Complete pad test and urodynamic study Exclusion Criteria: Pregnancy Urinary tract infection Had received pelvic reconstruction surgery

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Bladder outlet obstruction (BOO)<br>Between November 2011 and January 2017, medical records of all women with ≥stage II cystocele who underwent 20 min pad testing and urodynamic studies in a medical center were reviewed. Woman were defined as having BOO when Qmax was <12 mL/s and PdetQmax was ≥25 cmH2O with sustained detrusor contraction during voiding cystometry. | Diagnostic Test: Pad test<br>* 20-minutes pad test and urodynamic study including uroflowmetry, filling cystometry and voiding cystometry.<br>* Other names: Urodynamic study;|
| Detrusor underactivity (DU)<br>Between November 2011 and January 2017, medical records of all women with ≥stage II cystocele who underwent 20 min pad testing and urodynamic studies in a medical center were reviewed. Woman were defined as having DU when Qmax was <12 mL/s and PdetQmax was <10 cmH2O during voiding cystometry. | Diagnostic Test: Pad test<br>* 20-minutes pad test and urodynamic study including uroflowmetry, filling cystometry and voiding cystometry.<br>* Other names: Urodynamic study;|
| ND BOO/DU<br>Between November 2011 and January 2017, medical records of all women with ≥stage II cystocele who underwent 20 min pad testing and urodynamic studies in a medical center were reviewed. This group revealed no demonstrated bladder outlet obstruction nor detrusor underactivity. | Diagnostic Test: Pad test<br>* 20-minutes pad test and urodynamic study including uroflowmetry, filling cystometry and voiding cystometry.<br>* Other names: Urodynamic study;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| BOO | Bladder outlet obstruction: Qmax was <12 mL/s and PdetQmax was ≥25 cmH2O with sustained detrusor contraction during voiding cystometry. | November 2011 to January 2017 | 
| DU | Detrusor underactivity: <12 mL/s and PdetQmax was <10 cmH2O | November 2011 to January 2017 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cystocele, Bladder outlet obstruction, Detrusor underactivity, Urodynamic study