COVID - AirPollution

Study Overview
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Brief Summary
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Epidemiological data have related particulate matter (PM), nitrogen dioxide (NO2) and ozone (O3) to COVID-19 morbidity and mortality at the population level. Air pollution may be related to an increase in the COVID-19 severity and lethality through its impact on chronic diseases such as cardiovascular and respiratory diseases and diabetes that are also the main comorbidities associated with COVID-19. Epidemiological studies using individual data are needed to provide more precise estimate of the association between air pollution exposure and COVID-19. In this multicenter prospective study, the investigators will analyze the number of deaths in COVID-19 confirmed cases in geriatric patients according to long-term exposure to air pollution, taking into account confounders such as diabetes, hypertension, age, and BMI. Exposure to air pollution will be estimated as the mean concentration of air pollutants at the residential address during the previous two years. In addition, the investigators will explore the relationship between short-term variations in air pollutants, relative humidity, temperature, UV radiations, pollen and the occurrence of COVID-19.

Official Title
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Air Pollution and COVID-19 Mortality in Geriatric Patients: a Multicenter Study

Conditions
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COVID-19 Confirmed Cases, COVID-19 Mortality

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient over 60 years old (or dementia patient over 50 years old) Patient hospitalized in a geriatric department over the period from 2020/01/01 to 2020/06/01 Patient who underwent RT-PCR SARS-CoV-2 Patient (or trusted person/ legal guardian/curator, if applicable) who has given consent to the re-use of his/her data (patient data) for research purposes Exclusion Criteria: None

Ages Eligible for Study
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Minimum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| COVID-19 related-mortality | Association between COVID-19 related-mortality and air pollutants concentrations estimated at the residential address of geriatric patients during the last 2 years ( from 2018/01/01 to 2019/12/31) | COVID-19 mortality between 2020/01/01 and 2020/06/01 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| COVID-19 confirmed cases | Association between short- term variations in air pollutants, temperature, humidity, UV, pollens and the occurrence of COVID-19 confirmed cases. Short-term variations are defined as changes in air pollutants concentrations, temperature, humidity and pollen during the 20 days preceding the hospitalization. | COVID-19 confirmed cases between 2020/01/01 and 2020/06/01 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Air pollution, COVID-19, Respiratory viral diseases, PM- NO2-Ozone