Early Debridement Within 24 Hours After Surgery for Wound Healing of Abdominal Incision

Study Overview
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Brief Summary
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Wound healing after surgery is a complex procedure. Liquefaction of the fat and necrosis of inactivated tissue, as well as blood clots are always accumulated mostly within 24 hours after surgery. As such, early debridement within 24 hours after surgery might improve the healing of the wounds. This study is designed to compare the impact of early debridement of the wound versus regular dressing (24 hours later) on the wound healing. 100 patients will be included in this study, and divided into 2 groups randomly. Then, the healing of the wound, stitch removal time, incidence of incision complications will be compared between the two groups.

Official Title
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Early Debridement Within 24 Hours After Surgery Compared Routine Debridement (24 Hours Later) for Wound Healing of Abdominal Incision

Conditions
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Surgical Wound

Intervention / Treatment
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* Behavioral: Debridement Within 24 Hours After Surgery


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: the patient with major abdominal incision. Exclusion Criteria: Pregnant woman Patient with diabetes Patient with a history of cardiovascular disease, including coronary heart disease and stroke. Severe lung diseases such as COPD and asthma Patients undergoing emergent surgery or infectious surgery Patients with surgical site infection or abdominal abscess No autonomy, inability or unwillingness to participate in follow-up

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Debridement group<br>The subjects in this group will be debrided within 24 hours after surgery. | Behavioral: Debridement Within 24 Hours After Surgery<br>* Debrided within 24 hours after surgery<br>|
| No Intervention: Control group<br>The subjects in this group will experience wound dressing change regularly 24 hours after surgery. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| healing time, d (day) | since the ending of surgery to stitches off. | From date of surgery to the date of stitches off (up to 1 month) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| incidence of incision complications | The incision complications include infection, dehiscence, fat liquefaction, etc. | From the date of surgery to stitches off (up to 1 month) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Surgical Wound, Suture, Complication