Adderall XR and Processing Speed in Multiple Sclerosis (MS)

Study Overview
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Brief Summary
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Cognitive impairment, or problems with thinking and memory, is common in multiple sclerosis (MS) and can occur independently of physical disability. It is the most common reason, along with physical fatigue, for MS patients to stop working. The most frequent complaint is problems with multi-tasking or thinking quickly, which corresponds to impairment in the cognitive domain of processing speed. Currently there is treatment available to prevent relapses and physical disability but there are no medications that have been shown to treat cognitive impairment. Amphetamines have been beneficial for selective attention and processing speed in attention deficit hyperactivity disorder (ADHD) and traumatic brain injury. This is study will determine whether Adderall XR improves objective measures of processing speed and attention in MS patients impaired in this cognitive domain, by comparing two doses of Adderall XR (5 and 10mg) to placebo before and after the medication is administered. The results of this study will help provide data to design a larger study to determine if Adderall XR, and potentially other amphetamine drugs, will help treat cognitive impairment in MS patients.

Official Title
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Does Adderall XR Improve Processing Speed in Cognitively Impaired MS Patients?

Conditions
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Impaired Processing Speed, Cognitive Impairment, Multiple Sclerosis

Intervention / Treatment
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* Drug: Adderall XR 5mg
* Drug: Adderall XR 10 mg
* Drug: Placebo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: - Males/Females who are ≥ 18 years old and ≤ 59 years old Relapsing Remitting, Secondary Progressive or Primary Progressive MS, as per revised McDonald's Criteria Have not received corticosteroids in last thirty days or a relapse in the last ninety days An Expanded Disability Status Scale (EDSS) of ≤ 6.5 If female, must neither be pregnant nor breast-feeding Exclusion Criteria: - Have evidence of other medical cause(s) of cognitive impairment Have evidence of major depression as determined by a positive Beck Depression Index-Fast screen ≥ 13and/or by clinician interview or evidence of severe fatigue with a Fatigue Severity Scale ≥ 5. Have demonstrated a hypersensitivity to amphetamines in the past Have uncontrolled or labile hypertension (> 135/85 mm Hg, treated or untreated) Have a history of structural heart disease, including atherosclerosis or angina Have a diagnosis of bipolar disorder or a history of a psychotic episode The following medications are not permitted to be used within 14 days the study Monoamine Oxidase Inhibitors Sympathomimetics or methadone Antipsychotic agents Modafinil The following medications are permitted if the dose has been stable for ≥ 28 days Short acting benzodiazepines, qhs administration only Anticonvulsants, including gabapentin and pregabalin Bupropion Tricyclic Antidepressants Anti-spasmodics such as baclofen or tizanidine Anticholinergic medication Selective serotonin(-norepinephrine) reuptake inhibitors

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 59 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Placebo<br>treatment group #1 | Drug: Placebo<br> <br> |
| Active Comparator: Adderall XR 5mg<br>treatment group #2 | Drug: Adderall XR 5mg<br> <br> |
| Active Comparator: Adderal XR 10mg<br>treatment group #3 | Drug: Adderall XR 10 mg<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in score of Paced Auditory Serial Addition Test (PASAT) | measure of processing speed | pre and 7 hours post dose | 
| Change in Score of Symbol Digit Modalities Test (SDMT) | measure of processing speed | pre and 7 hours post dose | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cognitive Impairment, Multiple Sclerosis, Processing Speed, Treatment