Mind-Body Medicine for the Improvement of Quality of Life in Adolescents and Young Adults Coping With Lymphoma

Study Overview
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Brief Summary
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This trial studies how well a mind-body intervention works in improving overall quality of life in adolescents and young adults with lymphoma. A meditation based mind-body intervention may help lower distress, depressive symptoms, and anxiety in adolescents and young adults coping with lymphoma.

Detailed Description
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PRIMARY OBJECTIVE: I. Examine the feasibility of the mind-body intervention in adolescents and young adults (AYAs) with lymphoma. SECONDARY OBJECTIVE: I. Establish the initial intervention efficacy regarding psychological distress and cancer symptoms (tertiary objective) relative to an attention control (AC) group. EXPLORATORY OBJECTIVE: I. Explore mediation (e.g., mindfulness, compassion, social connection, inflammatory processes) and moderation (e.g., demographic and medical factors) of the intervention effects. OUTLINE: Patients are randomized to 1 of 2 groups. GROUP I: Patients attend meditation group sessions over 75 minutes once weekly for up to 5 weeks. GROUP II: Patients attend educational group sessions over 75 minutes once weekly for up to 5 weeks. After completion of study intervention, patients are followed at 6 and 12 weeks.

Official Title
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Mind-Body Medicine for Adolescents and Young Adults (AYA) Coping With Lymphoma

Conditions
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Lymphoma

Intervention / Treatment
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* Other: Educational Intervention
* Other: Meditation Therapy
* Other: Questionnaire Administration


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Participants between the ages of 18-39 diagnosed within 6 months with stage I-IV Lymphoma (all types) Eastern Cooperative Oncology Group (ECOG) performance status of 2 or below Having access to the internet Able to read, write and speak English Exclusion Criteria: Major psychiatric or cognitive deficits that would impede the completion of self-report instruments as deemed by the clinical team Regular (self-defined) participation in psychotherapy or a formal cancer support group

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 39 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Group I (meditation)<br>Patients attend meditation group sessions over 75 minutes once weekly for up to 5 weeks. | Other: Meditation Therapy<br>* Attend meditation sessions<br>* Other names: Meditation;Other: Questionnaire Administration<br>* Ancillary studies<br>|
| Active Comparator: Group II (educational)<br>Patients attend educational group sessions over 75 minutes once weekly for up to 5 weeks. | Other: Educational Intervention<br>* Attend educational sessions<br>* Other names: Intervention, Educational;Other: Questionnaire Administration<br>* Ancillary studies<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mind-body intervention in (AYAs) Adolescents and Young Adults with Lymphoma Questionnaire | We will examine preliminary evidence of intervention efficacy. Meaning and Purpose (1-5) Strongly Disagree 1- Disagree 2, Neither agree or disagree 3, Agree 4, Strongly agree 5. Day-to-Day Experiences (1-6) Almost Always-1, Very frequently-2, Somewhat Frequently -3, Somewhat Infrequently-4, Very Infrequently-5, Almost Never 6 | Up to 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Psychological distress and cancer symptoms (tertiary objective) relative to an attention control (AC) group Questionnaire | We will examine preliminary evidence of intervention efficacy. Meaning and Purpose (1-5) Strongly Disagree 1- Disagree 2, Neither agree or disagree 3, Agree 4, Strongly agree 5. Day-to-Day Experiences (1-6) Almost Always-1, Very frequently-2, Somewhat Frequently -3, Somewhat Infrequently-4, Very Infrequently-5, Almost Never 6 | Up to 12 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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All types of lymphoma