The Surgical Prognosis Based Diagnostic Strategy for Eosinophilic Chronic Rhinosinusitis

Study Overview
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Brief Summary
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Previous studies have demonstrated that the eosinophilic inflammation of nasal mucosa is associated with the uncontrolled condition of chronic rhinosinusitis after surgery. However, the definition of the eosinophilic chronic rhinosinusitis is not very clear. Japanese researchers have designed a scoring system to diagnose eosinophilic chronic rhinosinusitis. In this study, the investigators hope to examine the practicability of this scoring system and have a better knowledge of eosinophilic chronic rhinosinusitis in china.The retrospective study was conducted in a tertiary hospital. Participants received functional endoscopic sinus surgery more than 1 years were called back for evaluation. A diagnosis cut off value of eosinophil count was determined by the surgery prognosis. Then different factors were compared between participants with eosinophilic CRS and those with non-eosinophilic CRS to establish the appropriated diagnosis approach for eosinophilic CRS.

Detailed Description
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The retrospective study was conducted in a tertiary hospital. Participants received functional endoscopic sinus surgery more than 1 years were called back for evaluation. A diagnosis cut off value of eosinophil count was determined by the surgery prognosis. Then different factors were compared between participants with eosinophilic CRS and those with non-eosinophilic CRS to establish the appropriated diagnosis approach for eosinophilic CRS.

Official Title
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The Surgical Prognosis Based Diagnostic Strategy for Eosinophilic Chronic Rhinosinusitis: A Retrospective Study

Conditions
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Nasal Polyps, Sinusitis

Intervention / Treatment
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* Diagnostic Test: sinonasal outcome test-22


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosis of chronic rhinosinusitis according to European position paper of rhinosinusitis and nasal polyps 2007. Exclusion Criteria: Immunodeficiency diseases, history of head and/or facial trauma, cancer or organ transplant recipients. Pregnancy or lactation. Acute respiratory tract infection within one month before the study. Patients without pathological samples. Antrochoanal polyp and cyst of the paranasal sinuses.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| postoperational CRS<br>observe the symptoms and endoscopic appearance | Diagnostic Test: sinonasal outcome test-22<br>* Evaluate the nasal mucosal inflammation condition and overall quality-of-life of CRS patients<br>* Other names: Lund-Kennedy endoscopic score;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| nasal symptoms | presence of bothersome congestion or rhinorrhea or olfactory loss or headache.(VAS more than 7 points). | through study completion, an average of 2 year | 
| endoscopic appearance indicate the uncontrol of CRS | The presence of diseased mucosa (nasal polyps, mucopurulent secretions,and/or inflamed mucosa) under endoscopy. (Lund-kennedy endoscopic score: Polyp≥1 or Oedema≥2 or Discharge≥2; 0-Absence of polyps;1-polyps in middle meatus only;2-polyps beyond middle meatus but not blocking the nose completely;3-polyps completely obstructing the nose. Oedema: 0-absent; 1-mild; 2-severe.Discharge: 0-no discharge; 1-clear, thin discharge; 2-thick, purulent discharge.) | through study completion, an average of 2 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Chronic rhinosinusitis, Eosinophil, Surgery, Diagnosis