Does Delaying Curative Surgery for Colorectal Cancer Influence Long-term Disease Free Survival.

Study Overview
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Brief Summary
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This work is an original clinical research article describing the relationship between wait list tome for colorectal cancer patients and long-term survival. These findings are particularly relevant for management of surgical wait lists during crisis such as the Covid-19 pandemic. The lack of a relationship between wait list time and disease free survival and tendency for improved survival in the 4-6 week imply some colorectal cancer operations can be safely delayed during times of limited resources.

Detailed Description
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Background Surgical wait list time is a major problem in many health-care systems and its influence on survival is unclear. The aim of this study is to assess the impact of the wait list time on long term disease-free survival in patients scheduled for colorectal cancer resection. Materials and Methods A prospective, single center study was carried out in patients with stage I-III colorectal cancer scheduled for surgery between 2012-2017 at a Colorectal Surgery Unit of a tertiary care center. Wait list time was defined as the time from completion of diagnostic workup and definitive surgery and divided into 2-week intervals from 2 to 6 weeks. The outcome variables were 2- and 5-year disease free survival. Screening for disease progression was with carcinoembryonic antigen levels and chest/abdominal computed tomography scan. Data was collected prospectively and subsequently analyzed.

Official Title
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Does Delaying Curative Surgery for Colorectal Cancer Influence Long-term Disease Free Survival.: A COHORT STUDY

Conditions
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Colorectal Cancer

Intervention / Treatment
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* Other: Wait list time


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: American Joint Committee on Cancer (AJCC) stage I through III confirmed adenocarcinomas With colon or upper rectum as their primary site of malignancy according to International Classification of Diseases for Oncology, Third Edition topography code. Exclusion Criteria: Emergency surgery, More than one primary site, Synchronous metastasis or peritoneal carcinomatosis at the time of surgery If they received neoadjuvant chemoradiotherapy If they had a local transanal excision.
Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Wait list time 0-2 weeks<br>Wait list time 0-2 weeks | Other: Wait list time<br> <br> |
| Wait list time 2-4 weeks<br>Wait list time 2-4 weeks | Other: Wait list time<br> <br> |
| Wait list time 4-6 weeks<br>Wait list time 4-6 weeks | Other: Wait list time<br> <br> |
| Wait list time > 6 weeks<br>Wait list time > 6 weeks | Other: Wait list time<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Disease-free overall survival |  | 5 years |