Piloting Movement-to-Music With Arm-based Sprint-Intensity Interval Training Among Children With Physical Disabilities

Study Overview
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Brief Summary
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This study is investigating the potential effects of a high-intensity home-exercise program among children with cerebral palsy. The program includes rhythmic movements to music that are adapted for wheelchair uses and age-appropriate themes. This project has the potential to address a large knowledge gap in the extant literature, because there are no widely accessible, evidence-based, enjoyable, and age-appropriate modalities for improving cardiovascular fitness or cardiometabolic health among children with disabilities who have mobility disabilities.

Official Title
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Improving Cardiorespiratory Fitness and Cardiometabolic Health Among Children With Physical Disabilities Through Movement-to-Music Telehealth With Arm-based Sprint-Intensity Interval Training

Conditions
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Cerebral Palsy

Intervention / Treatment
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* Behavioral: Sprint-Intensity Interval Training with Telecoaching


Participation Criteria
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Eligibility Criteria
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We are recruiting 50 parent-child dyads. Childs are the participant undergoing the exercise intervention. Parents are required to support the safety and schedule of the child participant. Parents are considered participants due to their responsibilities. Inclusion Criteria: have a medical diagnosis of cerebral palsy, as determined by ICD-10 codes aged 6-17 years old a Gross Motor Function Classification System Level I-III (as determined via participant screening, explained in the protocol section below) medical clearance to participate in high-intensity exercise from a physician (using the attached medical screening form and explained in the intervention safety, monitoring, and response plan) access to a Wi-Fi Internet connection in the home via mobile phone or tablet computer a caregiver who will support and monitor the participant's safety during the intervention and manage the child's exercise schedule. Exclusion Criteria: physically active (defined as >150 minutes per week of self-reported moderate-to-vigorous intensity exercise in a typical week) cannot use their arms for exercise a Gross Motor Function Classification Level of IV-V complete blindness or deafness; Any past history of a contraindication to exercise testing according to American College of Sports Medicine (ACSM) guidelines (Liguori and American College of Sports Medicine, 2020): significant change in the resting electrocardiogram suggesting significant ischemia, myocardial infarction, or other cardiac event, unstable angina, uncontrolled cardiac dysrhythmias causing symptoms or hemodynamic compromise, symptomatic severe aortic stenosis, uncontrolled symptomatic heart failure, pulmonary embolus or pulmonary infarction, myocarditis or pericarditis, aneurysm. pregnant (due to radiation from a Dual Energy X-ray Absorptiometry [DEXA] scan) has not been seen by a physician within the last year uses a g-tube Eligible caregivers will include parents or legal guardians of the child, who can commit sufficient time to support the child in their roles for the study and communicate in English. Caregivers who have complete blindness or deafness will be excluded from participation.

Ages Eligible for Study
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Minimum Age: 6 Years
Maximum Age: 17 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Movement-to-Music<br>12 weeks of sprint-intensity interval training while following along with YouTube videos that include arm-based routines, with coaching through telecommunications. Participants are instructed to maintain their habitual diet and nutrition patterns | Behavioral: Sprint-Intensity Interval Training with Telecoaching<br>* Maximal intensity exercises that use the arms.<br>|
| No Intervention: Wait-list Control<br>12 weeks of maintaining habitual physical activity, diet, and nutrition patterns, until receiving 12 weeks of Movement-to-Music | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in pVO2 | peak oxygen consumption (mL/kg-1/min-1) obtained from a graded exercise test on an arm ergometer | Week 0, Week 13 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change in body weight | body weight in pounds (lbs) measured via DXA scan | Week 0, Week 13 | 
| changes in total body fat | body fat in pounds (lbs) measured via DXA scan | Week 0, Week 13 | 
| changes in total lean mass | lean mass in pounds (lbs) measured via DXA scan | Week 0, Week 13 | 
| changes in lean tissue percentage | percentage of lean tissue per whole body weight | Week 0, Week 13 | 
| changes in fat tissue percentage | percentage of fat tissue per whole body weight | Week 0, Week 13 | 
| changes in C-reactive protein | hsCRP (mg/L) measured via dried blood spot test | Week 0, Week 13 | 
| changes in Hemoglobin A1C | HbA1C (mmol/mol) measured via dried blood spot test | Week 0, Week 13 | 
| changes in fasting insulin | Fasting Insulin (μIU/mL) measured via dried blood spot test | Week 0, Week 13 | 
| changes in fasting triglycerides | Fasting Triglycerides (mg/dL) measured via dried blood spot test | Week 0, Week 13 | 
| changes in fasting high-density lipoprotein | HDL cholesterol (mg/dL) measured via dried blood spot test | Week 0, Week 13 | 
| changes in fasting low-density lipoprotein | LDL cholesterol (mg/dL) measured via dried blood spot test | Week 0, Week 13 | 
| Changes in systolic blood pressure | systolic blood pressure (mmHg) measured via blood pressure cuff | Week 0, Week 13 | 
| Changes in diastolic blood pressure | diastolic blood pressure (mmHg) measured via blood pressure cuff | Week 0, Week 13 |