Phonomotor Treatment of Word Retrieval Deficits in Individuals With Aphasia

Study Overview
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Brief Summary
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This is a behavioral speech therapy trial for individuals who have suffered a stroke on the left side of the brain and have difficulty speaking. The name of this disorder is called 'aphasia'. Individuals who participate in this study will receive 60 hours of therapy for free (2 hours/day, 5 days/week, 6 weeks).

Detailed Description
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The study design was a single group (n=26) with repeated testing (3 times) pre- and post-treatment. All participants received the same treatment protocol (described in detail in Appendix A and in Minkina et al. (under review)). In order to control for improvement in language function related to passage of time, and for the effect of repeated exposure to outcome measures, individuals were randomly assigned to one of two conditions: delayed treatment or immediate treatment (Figure 2). Participants who were randomized to the delayed group received repeated testing three times before and three times after a six-week delay. During the delay phase they were permitted to participate in usual speech-language care (e.g., conversation groups and individual therapy). Standardized assessments and outcome measures (described in detail below) were administered prior to the start of treatment (for both immediate and delayed groups), at the end of the delay phase (delayed group only), immediately after treatment termination, and at three months post-treatment.

Official Title
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Real Word Effects in Phonological Treatment for Word Retrieval

Conditions
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Aphasia

Intervention / Treatment
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* Behavioral: speech therapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: left hemisphere stroke monolingual English speaking right handed presence of aphasia Exclusion Criteria: preexisting neurological condition

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Immediate Treatment<br>individuals will receive 60 hours of speech therapy | Behavioral: speech therapy<br>* individuals will receive 60 hours of behavioral speech therapy<br>|
| Experimental: Delayed Treatment<br>individuals will receive 60 hours of speech therapy after 6 week delay period | Behavioral: speech therapy<br>* individuals will receive 60 hours of behavioral speech therapy<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Speech Production | percent change in the number of untrained words spoken correctly | Baseline to one week post treatment termination and three months post treatment termination |