Effect of Socheongryong-tang and Yeongyopaedok-san in Upper Respiratory Tract Infection

Study Overview
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Brief Summary
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The purpose of this study is to determine whether Socheongryong-tang (SCRT) and Yeongyopaedok-san (YPS) are effective in the treatment of upper respiratory tract infection.

Detailed Description
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Upper respiratory tract infections (URTIs) are the most prevalent disease of human beings, it incur a significant health burden on populations in terms of human suffering and economic losses. Usually, antibiotic therapy is not helpful since most infections are virally induced. Over 200 serologically different viral types are responsible for human URTIs, so that preventions of URTIs including vaccination are impassable. SCRT and YPS are widely used to treat the respiratory disease. The objective of this study is to determine the efficacy of SCRT and YPS in symptomatic relief of patients with URTIs.

Official Title
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Effect of Socheongryong-tang and Yeongyopaedok-san in Upper Respiratory Tract Infection

Conditions
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Upper Respiratory Tract Infections

Intervention / Treatment
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* Drug: SCRT
* Drug: YPS
* Drug: Placebo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 18 60 years old Clinical diagnosis of common cold Occurring no longer than 48 hours before enrollment Presented with runny nose, sore throat, plugged nose, scratchy throat, cough, hoarseness, headache, muscle ache (runny nose, sore throat and at least 1 of others or 1 of runny nose, sore throat and at least 3 of others) Exclusion Criteria: Allergic rhinitis, asthma, COPD, sinusitis (2 and more recurrence per year), septal deviation, anatomical otitis media, exudative pharyngitis Received antihistamines, NSAIDs, corticosteroids, antibiotics, decongestants Hepatic cancer, liver cirrhosis, renal failure, congestive heart failure Pregnant or lactation

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Placebo<br>Placebo (encapsulated starch + lactose) | Drug: Placebo<br>* 4 capsules, three times daily, for 7days or within symptom disappearance<br>|
| Experimental: SCRT(Socheongryong-tang )<br>encapsulated Socheongryong-tang extract | Drug: SCRT<br>* 4 capsules,three times daily, for 7days or within symptom disappearance<br>* Other names: Xiao-qing-long-tang;|
| Experimental: YPS (Yeongyopaedok-san)<br>Encapsulated Yeongyopaedok-san extract | Drug: YPS<br>* 4 capsules, three times daily, for 7days or within symptom disappearance<br>* Other names: Lian-qiao-bai-du-san;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes of score daily measured by WURSS-K before, during and after treatment |  | daily (7 days) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time of symptom disappearance |  | daily | 
| Changes of score daily measured by WURSS-K before, during and after treatment in pattern identification |  | daily (7days) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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upper respiratory tract infections, herbal medicine