Renal Acute MI Study

Study Overview
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Brief Summary
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The purpose of this study is to determine if a sizable myocardial infarction (heart attack) results in negative changes to renal structure and function (i.e. has a negative impact on the kidneys). To determine if the renal response to a myocardial infarction is a predictor of the patients future health.

Detailed Description
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Chronic heart and kidney disease are increasingly common in Western society. Both conditions are associated with frequent hospitalisation and increased mortality. Furthermore, there are mechanistic reasons why one condition may beget the other; the so-called cardiorenal syndrome. The investigators therefore wish to determine if a sizable myocardial infarction (heart attack) results in negative changes to renal structure and function (i.e. has a negative impact on the kidneys). The investigators also wish to determine if the renal response to a myocardial infarction is a predictor of the patients future health. To do this the investigators will measure markers of kidney function at the time of the heart attach, at discharge, 1 month, 6 months and 12 months and correlate this with the patients clinical condition.

Official Title
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Renal Structural, Functional and Cytokine Responses to Acute Myocardial Injury in Man

Conditions
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Myocardial Infarction, Kidney Function

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age > 18 years Have provided written informed consent Group 1: Non-Q wave MI patients normal cardiac and renal function No use of contrast eGFR > 60ml/min Group 2: Patients undergoing coronary angiography +/- PCI for stable CAD or non-Q wave MI normal cardiac and renal function eGFR > 60ml/min Group 3: Acute STEMI Full thickness infarct (STEMI) eGFR ≥ 60ml/min Group 4: Acute STEMI Full thickness infarct (STEMI) eGFR < 60ml/min Exclusion Criteria: Unable or unwilling to comply with the study protocol Underlying medical condition which, in the opinion of the investigator, will effect the safely or efficacy of the study

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group 1 - Control<br>Non-Q wave MI subjects with normal cardiac and renal function (defined as eGFR >60ml/min) not undergoing a cardiac procedure involving contrast will serve as control for renal injury subjects. | |
| Group 2 - stable CAD or non-Q wave MI<br>Patients undergoing coronary angiography +/- PCI for stable CAD or non-Q wave MI with normal cardiac and renal function (defined as eGFR >60ml/min) will control for the contrast STEMI patients are likely to receive as part of their post-MI management | |
| Group 3 - Acute STEMI without chronic kidney disease<br>Acute STEMI patients (n=40), without chronic kidney disease (defined as eGFR ≥60ml/min). | |
| Group 4 - Acute STEMI with kidney disease<br>Acute STEMI patients (n=40), with evidence of background chronic kidney disease (eGFR <60ml/min). | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| changes in renal function and structure |  | Baseline, discharge, 1 month, 6 months and 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| renal response to myocardial infarction |  | baseline, discharge, 1 month, 6 months and 12 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Myocardial Infarction (MI), Kidney function, bio-markers