Polyphenol Rich Supplementation on Markers of Recovery From Intense Resistance Exercise

Study Overview
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Brief Summary
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Strength training is commonly used as an intervention to increase muscle mass, thus improving a person's ability to undertake activities of daily living, or enhance athletic performance. The strength training regimen itself, while ultimately having beneficial effects, causes muscle fibers to be damaged, which the body has to recover from. As the body recovers, it rebuilds the muscle tissue and after multiple consecutive bouts of strength training, the muscle eventually becomes larger and stronger. Thus, it is the recovery from strength training exercise that ultimately determines how well the body adapts. Where inadequate recovery could eventually lead to overtraining and/or injury, optimizing the recovery process from strength training could maximize strength training adaptations. This concept of optimizing recovery has led to development of many supplements, including antioxidants, which may reduce the damage associated with strength training activities and therefore enhance positive adaptations. The purpose of this study is to assess the ability of a polyphenol rich supplementation to aid the recovery process from a demanding bout of resistance exercise

Official Title
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Polyphenol Rich Supplementation on Markers of Recovery From Intense Resistance Exercise

Conditions
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Muscle Soreness

Intervention / Treatment
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* Dietary Supplement: Tart Cherry
* Other: Placebo Oral Capsule [CEBOCAP]


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 6 months of resistance training experience with barbel back squat exercise Exclusion Criteria: Not currently taking any antioxidant supplements, not currently using any hormone replacement therapy or anabolic androgenic steroids.

Ages Eligible for Study
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Minimum Age: 21 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Interventional Model Description: 20 male participants will start with a familiarization visit where they will receive either the placebo supplement or the polyphenol rich supplement that they will take for 7 days. After taking the supplement, the participants will come back and run through the acute resistance exercise protocol as well as return the next day for a post test. Next, the participants will undergo a wash out phase where they will not take any supplementation. At the end of these 2 weeks, the participants will then take the other supplement (i.e. if they took the polyphenol rich supplement in the first phase they will take the placebo supplement in the second phase). After a week of taking their assigned supplement, participants will complete the acute resistance exercise protocol and the post test.
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Placebo<br>Rice flour capsule | Other: Placebo Oral Capsule [CEBOCAP]<br>* Rice flour<br>|
| Active Comparator: Polyphenol Rich Supplement<br>NordicCherry Tart Cherry Extract Powder 500 mg in capsule form | Dietary Supplement: Tart Cherry<br>* NordicCherry Tart Cherry Extract Powder 500 mg from Specnova, inc<br>* Other names: NordicCherry Tart Cherry Extract Powder 500 mg;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Assessment of Oxidative Stress | Blood analyses will be used, 8 mL of blood will be taken from the participant six times per condition. The blood will be centrifuged to separate the serum/ plasma and analyzed by enzyme- linked immunosorbent assay (ELISA) for c- reactive protein and creatine kinase, and oxidative damage | 7 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Muscle soreness | Subjects will mark a line on a 10cm scale that corresponds to the amount of muscular soreness they currently perceive | 7 weeks | 
| Vertical Jump Performance | Subjects will be instructed to stand on a NeuroCom Balance Manager forceplate with hands on hips. Subjects will then be instructed to perform 3 consecutive vertical jumps, as high as possible with minimal time between jumps. The jumps will later be assessed for power production. | 7 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Polyphenol rich supplementation, Tart cherry, Lifting, Recovery