Effects of 6 Weeks High-intensity Interval Training Among Spinal Cord Injury

Study Overview
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Brief Summary
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The training consists of 6 weeks of functional electrical stimulation leg cycling exercise (FES-LCE) program. The training program comprises of 2 visits per week. Each visit consists of FES-LCE for 45 minutes. Throughout the 6 weeks program, there will be testing/assessment sessions on week 1, week 3 and week 6. The FES will be applied via surface electrodes and the stimulation intensity based on the participant's tolerance level.

Official Title
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Effects of 6 Weeks High-intensity Interval Training on Muscle Strength and Cardiorespiratory Response Among Spinal Cord Injury

Conditions
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INCOMPLETE SPINAL CORD INJURY (ASIA D)

Intervention / Treatment
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* Other: Functional Electrical Stimulation Leg Cycling Exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Participants were diagnosed with incomplete spinal cord injury (SCI) at least one year prior to participation. Age between 18-75 years old. Both male and female. Have at least 90º bilateral knee flexion. Moderate neurological induce weakness in quadriceps muscle of 1 leg that is responsive to electrical stimulation (moderate weakness was defined as 3/5 or 4/5 on manual muscle testing). Able to perform cycling activity. Normal upper limb function. Able to follow command. Exclusion Criteria: Had a recent history of trauma to the lower limb. Severely infected skin pressure sore on weight-bearing skin areas. Illness caused by acute urinary tract infection. Uncontrolled spasticity or pain. History of cardiovascular/cardiorespiratory problem. Orthostatic hypotension. Unhealed decubiti at electrode placement area. Recurrent autonomic dysreflexia. Active heterotopic ossification. Other peripheral or central neurologic injury.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 4 MIN X 4 MIN HIIT of FES-LCE<br>4 min of high-intensity phase intersperses with 4 min of low-intensity phase for a total of 5 bouts. | Other: Functional Electrical Stimulation Leg Cycling Exercise<br>* FES- leg cycling for 45 minutes (3 min warm up + 40 min HIIT + 2 min cooldown). The FES will be applied via surface electrodes and the stimulation intensity based on your tolerance level.<br>|
| Experimental: 2 MIN X 2 MIN HIIT of FES-LCE<br>2 min of high-intensity phase intersperses with 2 min of low-intensity phase for a total of 10 bouts. | Other: Functional Electrical Stimulation Leg Cycling Exercise<br>* FES- leg cycling for 45 minutes (3 min warm up + 40 min HIIT + 2 min cooldown). The FES will be applied via surface electrodes and the stimulation intensity based on your tolerance level.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes of peak torque of Quadriceps and Hamstring | Isometric peak torque for quadriceps and hamstring will be measured using Biodex isokinetic machine. | Changes of peak torque at 6 week | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes of peak VO2 | Peak VO2 will be measured using Cosmed Quark CPET system apparatus | Changes of peak VO2 at 6 week | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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HIGH INTENSITY INTERVAL TRAINING, INCOMPLETE SPINAL CORD INJURY, MUSCLE STRENGTH, CARDIO-RESPIRATORY FITNESS