Molekule for Allergic Rhinitis/Asthma

Study Overview
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Brief Summary
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Exposure to airborne allergens and pollutants is linked to symptom severity of allergies, asthma and other respiratory problems. In this study an air purifier using photo-electrochemical oxidation technology (PECO) will be used in the home environment of study participants. The investigator will assess the reduction of symptoms from allergic rhinitis/conjunctivitis and asthma.

Detailed Description
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The purpose of this study is to assess the efficacy of the portable PECO air purifier in reducing symptoms from allergic rhinitis and asthma. Using a randomized, double blinded placebo, controlled trial we will be then able to assess if there are any changes after the use of the PECO air purifier after completing an initial baseline survey & comparing to the exit survey. This is a double-blind study, which means that neither the participant nor the investigator knows which device is being used until after the trial is over.

Official Title
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Molekule for Allergic Rhinitis/Asthma

Conditions
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Asthma, Allergic Rhinitis, Allergic Conjunctivitis

Intervention / Treatment
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* Other: Active air purifier in respiratory allergies/asthma
* Other: Sham air purifier


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Chronic allergic rhinitis and/or conjunctivitis by history History of adult asthma requiring medications now or in the past Age ≥18 CARAT score less than 24 Exclusion Criteria: Participant is <18 years-old Use of systemic corticosteroids within 14 days of study initiation Treatment with biologic agents or allergen immunotherapy Treatment with other immunomodulators (cyclosporine, azathioprine, hydroxychloroquine, etc) Sensitive to fan sound or blue/purple light at night time

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Active air purifier arm<br>Active portable air purifier for 1 month at bedside | Other: Active air purifier in respiratory allergies/asthma<br>* Continuous use of air purifier to improve allergies and asthma control<br>|
| Sham Comparator: Sham air purifier arm<br>Placebo portable air purifier for 1 month at bedside | Other: Sham air purifier<br>* control arm<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Control of Allergic Rhinitis and Asthma Test (CARAT) score | CARAT will measure the change in control scores of respiratory allergies and asthma. Scale 0 (Worse control of allergy and asthma) to 30 (Best control of allergy and asthma). The higher score the better control of allergy and asthma. There are 10 individual questions, scoring from 0-3. | 4 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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environmental intervention, asthma, allergies, air purifier