linjc16/ctgov huggingface dataset:
Evaluation of a Spatio-behavioral Application

Study Overview
=================
Brief Summary
-----------------
The CIRCUIT program (Centre pédiatrique d'interventions en prévention et en réadaptation cardiovasculaire) of the CHU Sainte-Justine is a multidisciplinary, personalized intervention for children with cardiovascular risk. This program includes an evaluation of the physical activity pattern using wearable sensors (accelerometer, heart rate monitor and GPS), to replace the physical activity practice of the patients in their respective real life context. The accelerometer will measure physical activity and heart rate, while the GPS will serve to obtain precise information about places visited and travels in the neighborhood. The data obtained with these tools will serve to develop indicators of the environmental diagnosis. This information will help to personalize the intervention for each patient.

Official Title
-----------------
Enhancing Physical Activity Levels in Youth at Risk for Cardiovascular Disease: Evaluating a Spatio-behavioral Intervention.

Conditions
-----------------
Physical Activity

Intervention / Treatment
-----------------
* Behavioral: multi-sensor lifestyle intervention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: - Children at risk of cardiovascular disease, including children with diabetes mellitus, overweight/obesity, hypertension, dyslipidemia Exclusion Criteria: - Patients with physical or psychological problems that impair their ability to participate in physical activity

Ages Eligible for Study
-----------------
Minimum Age: 5 Years
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: multi-sensor lifestyle intervention<br> | Behavioral: multi-sensor lifestyle intervention<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Physical activity | Accelerometer measured physical activity | Baseline |
Effect Posterior QLB on Atelectasis

Study Overview
=================
Brief Summary
-----------------
We aimed to investigate the effect of posterior quadratus lumborum block on postoperative atelectasis in inguinal hernia surgery in pediatric patients.

Official Title
-----------------
The Effect of Ultrasound-guided Posterior Quadratus Lumborum Block on Atelectasis in Pediatric Patients

Conditions
-----------------
Atelectasis, Block, Pediatrics, Quadratus Lumborum Block

Intervention / Treatment
-----------------
* Procedure: posterior quadratus lumborum block


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: under 2 years old, ASA I-II risk group Patients who underwent an inguinal hernia operation under general anesthesia, posterior quadratus lumborum block for postoperative analgesia or pain treatment with conventional method Patients whose informed consent was read and approval was obtained from him and his guardian Exclusion Criteria: who do not want to participate in the study, ASA III-IV-V patients

Ages Eligible for Study
-----------------
Minimum Age: 0 Years
Maximum Age: 2 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Posterior quadratus lumborum block<br> | Procedure: posterior quadratus lumborum block<br>* administration local anesthetic solution between the middle layer of the thoracolumbar fascia and QL muscle at the posterior edge of the quadratus lumborum muscle<br>|
| Sham Comparator: control group<br> | Procedure: posterior quadratus lumborum block<br>* administration local anesthetic solution between the middle layer of the thoracolumbar fascia and QL muscle at the posterior edge of the quadratus lumborum muscle<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| lung ultrasound score | atelectasis | up to 1 hour after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| pain scores | Flacc scores | up to 6 hour after surgery | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
postoperative atelectasis, ultrasound, lung ultrasound score, posterior QLB
Novel Approaches in Linkage Analysis for Complex Traits

Study Overview
=================
Brief Summary
-----------------
To develop new statistical methods to explore genetic mechanisms that contribute to the development of hypertension.

Detailed Description
-----------------
BACKGROUND: Hypertension affects 50 million Americans and is the single greatest risk factor contributing to diseases of the brain, heart, and kidneys. There is a strong evidence that hypertension has a genetic basis. The study will develop novel approaches to better understand the genetic mechanisms contributing to measures of blood pressure (BP) level, diagnostic category (hypertension versus normotension) and correlated traits. DESIGN NARRATIVE: This genetic epidemiology study will develop novel approaches to better understand the genetic mechanisms contributing to measures of blood pressure (BP) level, diagnostic category (hypertension versus normotension) and correlated traits. The first aim is to localize genes influencing measures of blood pressure levels, diagnostic category and their correlates. This will be done by applying genome-wide multivariate linkage analyses based on the variance components approach and utilizing clusters of traits correlated with measures of blood pressure and/or diagnostics category. The second aim is to develop exploratory diagnostic tools for linkage analysis of complex traits to further enhance our ability to localize genes influencing measures of blood pressure, diagnostic category and their correlates. This will be done by extending the diagnostic tools used in regression analysis to the variance components approach used for linkage analysis of quantitative traits. In this study for example, it can be used to identify outlier families since previous studies have shown that families with outlier values yield false-positive results. Tree-structure models will also be extended to pedigree data. Tree-based modeling is an exploratory technique for uncovering structure in the data. The use of tree-structure models is advantageous because no assumptions are necessary to explore the data structure or to derive parsimonious model. These models are accurate classifiers (binary outcome) and predictors (quantitative outcomes). All these tools will be incorporated in the S-Plus software as a function. S-Plus was selected due to its capability and flexibility for analyzing large data sets.

Conditions
-----------------
Cardiovascular Diseases, Heart Diseases, Hypertension

Participation Criteria
=================
Eligibility Criteria
-----------------
No eligibility criteria
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Post-Stroke Osteopathy

Study Overview
=================
Brief Summary
-----------------
The sudden biomechanical inactivation, direct neuro-humoral effects and sustained systemic stress reaction, which commonly occur after stroke or TIA, all may be of relevance in triggering alterations in bone metabolism and remodelling of bone microstructure. The objectives of this observational pilot study are to characterize falls and fractures and their circumstances (sex and age specific incidence, time course, risk conditions, localization) in ischemic stroke patients, study changes in the bone microstructure after ischemic stroke supported by high-resolution peripheral quantitative Computer Tomography, unravel a molecular mechanisms underlying the increased fracture risk (focus on Wnt-signaling and ß-adrenergic projection), establish risk factors to estimate the risk of falls based on information from gait analysis as well as construct deep learning algorithms to identify bone microstructure parameters for predicting fractures.

Official Title
-----------------
Post-Stroke Osteopathy: Characterization of Fractures and Changes in the Bone Microstructure After Ischemic Stroke or TIA

Conditions
-----------------
Stroke (CVA) or TIA, Fracture, Fall

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Inclusion in the STROKE-CARD Registry Study Modified Rankin Scale (mRS) < 5 Provision of signed and dated informed consent form Willingness to comply with all study procedures and ability to participate in the study over the complete study duration Exclusion Criteria: Persistent motor deficit before the onset event Not able to walk without walking aid or not able to put the full bodyweight on either leg before the onset event Medical history of stroke Premedication with Corticosteroids for more than 6 Weeks or Pioglitazone or Bisphosphonate within the last 12 months Limb amputation BMI < 18,5 kg/m2 or > 35 kg/m2 Present or previous fracture in the distal Radius or Tibia interfering with HR-pQCT Movement disorder interfering with HR-pQCT imaging Women of childbearing potential

Ages Eligible for Study
-----------------
Minimum Age: 60 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patients with and without fractures |  | 12 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Bone microstructure, high-resolution peripheral quantitative Computer Tomography
Optimal Endoscopic Suturing Pattern for Esophageal Stent Fixation

Study Overview
=================
Brief Summary
-----------------
Researchers are trying to determine which suturing pattern for esophageal stent placement is more effective in a randomized fashion as currently what suturing pattern to use is an arbitrary decision.

Detailed Description
-----------------
The participants who are receiving esophageal stent placement will be prospectively randomized to receive two suturing patterns (simple interrupted pattern and triangular pattern) for endoscopic esophageal stent fixation. We will investigate rate of the stent migration at 3-4 weeks by endoscopy after the stent placement as part of routine clinical care. Data of the duration of endoscopic suturing, adverse events, details of the stent used, indication for use will also be collected.

Official Title
-----------------
Suturing Pattern for Endolumenal Stenting Procedures

Conditions
-----------------
Stent Migration, Esophageal Stenosis, Suture, Complication

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Subjects aged 18 or above Subjects undergoing esophageal stent placement with any indication Exclusion Criteria: Imprisoned individuals, Institutionalized patients Inability or unwillingness of individual

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Simple interrupted suture group<br>Participants will have a simple interrupted suturing pattern, determined by care provider, at the time of esophageal stent placement for esophageal stent fixation as part of standard care and will have an endoscopy at 3-4 weeks after the stent placement as part of a routine follow-up. | |
| Triangular suture group<br>Participants will have a triangular suturing pattern, determined by care provider, at the time of esophageal stent placement for esophageal stent fixation as part of standard care and will have an endoscopy at 3-4 weeks after the stent placement as part of a routine follow-up. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Stent migration rate | Number of participants with stent migration as assessed by objective evidence of stent migration on endoscopy at 3-4 weeks after esophageal stent placement | 4 weeks post stent placement | 
| Adverse Events | Number of adverse events reported | 4 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Esophageal stenosis, Endoscopic suturing, Esophageal stent fixation, Stent migration
Carotid B-Mode Ultrasound Study to Compare Anti-Atherosclerotic Effect of Torcetrpib/Atorvastatin to Atorvastatin Alone.

Study Overview
=================
Brief Summary
-----------------
The Torcetrapib project was terminated on December 2, 2006 due to safety findings. To look at ultrasound images taken in the carotid arteries and to look at various lipids in the blood of people with heterozygous familial hypercholesterolemia

Detailed Description
-----------------
For additional information please call: 1-800-718-1021

Official Title
-----------------
Phase 3 Multi-Center, Double-Blind, Randomized, Parallel Group, Carotid B-Mode Ultrasound Evaluation of the Anti-Atherosclerotic Efficacy, Safety and Tolerability of Fixed Combination CP-529,414/Atorvastatin, Administered Orally, Once Daily (QD) for 24 Months, Compared With Maximally Tolerated Atorvastatin Therapy Alone, in Subjects With Heterozygous Familial Hypercholesterolemia.

Conditions
-----------------
Hypercholesterolemia, Familial, Hyperlipidemia

Intervention / Treatment
-----------------
* Drug: torcetrapib/atorvastatin
* Drug: atorvastatin


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosis of Heterozygous Familial Hypercholesterolemia At least 18 years of age Exclusion Criteria: Women who are pregnant or lactating, or planning to become pregnant. Subjects with a clinically indicated need for statin (HMG-CoA reductase inhibitor) therapy other than atorvastatin or other concomitant therapy with known lipid altering effects on LDL-C and HDL-C including fibrates and nicotinic acid (high doses) Subjects taking any drugs known to be associated with an increased risk of myositis in combination with HMG-CoA reductase inhibitors Subjects with any other medical condition or laboratory abnormality which could affect subject safety, preclude evaluationof response, or render unlikely that the subject would complete the study

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: torcetrapib/atorvastatin|nan|
|Drug: atorvastatin|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in intima media thickness as measures by carotid ultrasound |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in levels of lipids and other biomarkers. |  |  |
Innovative Smartphone Application of a New Behavioral Method to Quit Smoking: Pilot Trial (Smart Quit)

Study Overview
=================
Brief Summary
-----------------
This innovative study will compare a newly developed smartphone application for Acceptance and Commitment Therapy (ACT) to a smartphone application for traditional cognitive behavioral therapy (CBT).

Detailed Description
-----------------
The study matches these National Cancer Institute (NCI) research funding priorities: (1) increasing the dissemination of smoking cessation treatments and (2) new treatment approaches to boost the effectiveness of cessation interventions.

Official Title
-----------------
Innovative Smartphone Application of a New Behavioral Method to Quit Smoking: Pilot Randomized Trial

Conditions
-----------------
Smoking

Intervention / Treatment
-----------------
* Behavioral: ACT
* Behavioral: CBT


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age 18 or older smokes at least five cigarettes daily for at least past 12 months wants to quit in the next 30 days interested in learning skills to quit smoking willing to be randomly assigned to either smartphone application resides in US has at least daily access to their own personal Apple iPhone 4, 4s, or 5 knows how to login and download a smartphone application from Apple's App Store Store willing and able to read in English not participating in other smoking cessation interventions (including our other intervention studies) has never used the NCI's Quit Guide smartphone application.] willing to complete one follow-up survey provide email, phone, and mailing address. Exclusion Criteria: The exclusion criteria are the opposite of the inclusion criteria above.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: ACT<br>Acceptance & Commitment Therapy | Behavioral: ACT<br> <br> * Other names: Acceptance & Commitment Therapy;|
| Active Comparator: CBT<br>Cognitive Behavioral Therapy | Behavioral: CBT<br> <br> * Other names: Cognitive Behavioral Therapy (CBT);|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 7-day and 24-hour point prevalence quit rates |  | 2 months post randomization | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
smoking cessation, quit smoking
Management of Large Retained Products of Conception (> 4 cm): Need for an Standardized Procedure.

Study Overview
=================
Brief Summary
-----------------
Collection of relevant data form patients who were treated in the Ghent University Hospital in the context of a placental remnant lager than 4 cm, performing statistical analyzes on the collected data, reviewing the literature on the subject and formulation of a recommendation for treatment of these large placental remnants.

Official Title
-----------------
Management of Large Retained Products of Conception (> 4 cm): Need for an Standardized Procedure.

Conditions
-----------------
Placenta, Retained, Placenta; Retention, Fragments, Complicating Puerperium, Without Hemorrhage, Placenta; Retention, Fragments, Complicating Puerperium (Delayed Hemorrhage), Pregnancy Related, Hysteroscopy / Methods, Retrospective Studies, Vacuum Curettage

Intervention / Treatment
-----------------
* Procedure: kind of surgery


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: retained products of conception larger than 4 cm in largest dimension Exclusion Criteria: retained products of conception 4 cm or smaller in largest dimension

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with a placental remnant in medical history<br> | Procedure: kind of surgery<br>* hysteroscopy, curettage, other<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hysteroscopy | Kind of surgery to remove retained products of conception | time of surgery | 
| Vacuum Curettage | Kind of surgery to remove retained products of conception | time of curettage | 
| Polyp forceps | Surgical instrument to remove retained products of conception | time of surgery | 
| Prostaglandines | Pharmacological agent to remove retained products of conception | time of surgery |
Bundle Evaluation in Extra Renal Epuration, Incidence of Thrombosis

Study Overview
=================
Brief Summary
-----------------
This is a prospective observational clinical multicentric study in ICU with acute renal failure requiring renal replacement therapy.

Detailed Description
-----------------
Prospective before / after observational clinical multicentric study on ICU acute kidney injury during renal replacement therapy. Evaluation of incidence and exposure to hemofilter clotting. The after phase will consist in medical measures (help for prescription) and paramedical measures (stop the filtration flow during the patient's mobilization).

Official Title
-----------------
Bundle Evaluation in Extra Renal Epuration, Incidence of Thrombosis

Conditions
-----------------
Adults Receiving Renal Replacement Therapy

Intervention / Treatment
-----------------
* Other: renal replacement therapy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adult (age > 18 years) Renal replacement therapy (continuous veino-veinous hemofiltration or continuous veino-veinous hemodiafiltration) Consent of patients Exclusion Criteria: Use citrate anticoagulation Age below 18 years

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Hemofilter<br> | Other: renal replacement therapy<br>* Prospective observational clinical multicentric study in ICU with acute renal failure requiring renal replacement therapy.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hemofilter lifetime |  | at day 1 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hemofilter clotting risk factors |  | at day 1 | 
| hemofiltration duration |  | at day 1 | 
| down time value |  | at day 1 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Renal replacement therapy, Hemofilter clotting, Clotting risk factor, Hemofilter clotting prevention