linjc16/ctgov huggingface dataset:
Chinese FPD Registry

Study Overview
=================
Brief Summary
-----------------
The purpose of the Chinese Familial Parkinson's disease Registry (CFPDR) is to develop a database of patients with familial Parkinson's disease (PD) in China.

Detailed Description
-----------------
Parkinson's disease (PD) is the second most common disorder among degenerative neurological disease. Familial PD (FPD) has its unique clinical feature and genetic basis. We aim to establish a database of FPD,and characterize the clinical feature, genetic basis, environmental factors and their interactions FPD in China. Method: Clinical feature will be measured by scales and neurological tests.Standard scales includes: Unified Parkinson's Disease Rating Scale(UPDRS), Hoehn-Yahr stages, NMSS, MMSE, PDSS(Parkinson disease sleep scales),Rapid Eye Movement Sleep Behaviour Disorder Questionnaire(RBDQ-HK),ESS(Epworth Sleepiness Scale),Rome III functional constipation scale，SCOPA-AUT (the Scale for Outcomes in PD for Autonomic Symptoms)，PFS(Parkinson Fatigue Scale)，CH-RLSq，Hyposmia rating scale(HRS)HAMILT depression scale，the 39-item Parkinson's Disease Questionnaire(PDQ-39)，Freezing of gait scale(FOG)，dyskinesia related scales, Wearing-off scale(WO) Peripheral blood from patients and other members in family will be collected for familial PD genetic testing. The environmental factors are exploded by questionnaires including smoking,drinking, pesticide and heavy metals.

Official Title
-----------------
The Chinese Familial Parkinson's Disease Registry

Conditions
-----------------
Parkinson Disease

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Clinical diagnosis of Parkinson's disease, and either family history of Parkinson's disease (first or second degree family member affected by Parkinson's disease) AND/OR Clinical diagnosis of Parkinson's disease and their parents are close relatives(First or second degree family member of an Index Case, affected or unaffected by Parkinson's disease). Exclusion Criteria: Lack of capacity to consent to participate in the project
Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Database of Familial Parkinson's disease | To collect 1500 patients with familial Parkinson's disease and establish the database of Familial Parkinson's disease (FPD) in mainland China. | 10 years | 
| Risk Factors | To characterize clinical feature and environmental factors among Chinese familial parkinson's disease | 10 years | 
| Genetic Basis | To characterize the genetic basis of Chinese FPD and detect clinically relevant genetic variants in these cases | 10 years |
Community Web Health Portal for Diabetes Prevention

Study Overview
=================
Brief Summary
-----------------
This study supports the development of a diabetes prevention and control community web portal. The portal will feature an innovative personalized impediment profiling tool and reward program. The program, Nutrition Navigation on-Line Edge, or NnoLEDGE, will be used by community consortiums for weight loss and diabetic health interventions within their communities. The Specific Aims are: Recruitment of local community organizations to participate as a community health consortium Development of a comprehensive community health web portal consisting of a web portal, impediment profiler, community toolbox, and rewards system Final evaluation of the system with regard to participants' attitudes and perceptions of using NnoLEDGE as a tool for weight control and diabetes prevention to determine feasibility.

Official Title
-----------------
The Primary Goal of the Phase I Research Was to Demonstrate Feasibility of Creating and Running an Incentive-based Wellness Portal for a Local Community (Princeton, NJ) That Involved Designing the System, Building a Prototype, Testing the System, and Assessing User Acceptance.

Conditions
-----------------
Obesity, Health Knowledge

Intervention / Treatment
-----------------
* Behavioral: www.princetonlivingwell.com


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: can read and write English Exclusion Criteria: cannot read and write Engish

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years


Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: program feasibility<br> | Behavioral: www.princetonlivingwell.com<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| attitudes and perceptions re: feasibility of web portal | Subjects will complete surveys aimed at assessing their attitudes and perceptions of the feasibility of the use of the nNoledge tool for weight control and prevention of diabetes | 2 months |
Stakeholder Assessment of Implementing the Commission on Cancer Operative Standards for Cancer Surgery

Study Overview
=================
Brief Summary
-----------------
This study investigates the barriers to implementing breast Synoptic Operative Reports. Information from this study may help researchers identify performance objectives for the breast Synoptic Operative Reports to be adopted, implemented and continued.

Detailed Description
-----------------
PRIMARY OBJECTIVES: I. To identify and describe barriers to implementing breast Synoptic Operative Reports (SOR) from multiple constructs. Ia. Identify performance objectives - who must do what - for the breast SOR to be adopted, implemented, and continued. OUTLINE: Participants participate in interview over 30-60 minutes.

Official Title
-----------------
Stakeholder Assessment of Implementing the Commission on Cancer Operative Standards for Cancer Surgery

Conditions
-----------------
Breast Carcinoma

Intervention / Treatment
-----------------
* Other: Interview


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adults >= 18 years Available phone or device for contact English speaking Works at Commission on Cancer (CoC) - accredited cancer program Exclusion Criteria: none

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Observational (interview)<br>Participants participate in interview over 30-60 minutes. | Other: Interview<br>* Participate in interview<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Barriers to implementing breast Synoptic Operative Reports | This is a qualitative study in which we will conduct in-depth, semi-structured interviews with key stakeholders. A template analysis identifying priori themes will be used, then coding for impact and/or implementation strategy. | Up to 2 years | 
| Performance objectives for the breast Synoptic Operative Reports to be adopted, implemented, and continued | This is a qualitative study in which we will conduct in-depth, semi-structured interviews with key stakeholders.A template analysis identifying priori themes will be used, then coding for impact and/or implementation strategy. | Up to 2 years |
Phase II Study of Weekly Paclitaxel (BMS-181339) in Patient With Non-Small Cell Lung Cancer (NSCLC)

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate the efficacy and the safety of paclitaxel given weekly in patients with advanced or recurrent non-small cell lung cancer

Official Title
-----------------
Phase II Study of Weekly Paclitaxel (BMS-181339) in Patient With Non-Small Cell Lung Cancer (NSCLC)

Conditions
-----------------
Non-Small Cell Lung Cancer

Intervention / Treatment
-----------------
* Drug: Paclitaxel


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with no prior chemotherapy who meet either of the listed below: Patient with stage IIIB or IV disease Patients with recurrent disease following potentially curative surgical resection Patients with previous chemotherapy up to one regimen Exclusion Criteria: Patients with serious, uncontrolled medical illness Patients with previous therapy with taxanes

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 74 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Paclitaxel<br> | Drug: Paclitaxel<br>* Solution, IV, 100 mg/m², weekly for 6 of 7 weeks, until disease progression or unacceptable toxicity became apparent<br>* Other names: BMS-181339;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Response rate [defined as total number of patients with complete and partial response divided by number of response-evaluable patients] based on Response Evaluation Criteria in Solid Tumors (RECIST) in patients with no prior chemotherapy |  | Each 49 day course of treatment until withdrawal or unacceptable toxicity | 
| Safety: incidence and severity of adverse events, laboratory test abnormalities |  | Each 49 day course of treatment until withdrawal or unacceptable toxicity | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Duration of response, [measured from the time that measurement criteria are met for complete or partial response until the first date that recurrent or progressive disease is objectively documents] |  | Each 49 day course of treatment until withdrawal or unacceptable toxicity |
Traumatic Proximal Femoral Fractures in Adults

Study Overview
=================
Brief Summary
-----------------
Statistical analysis for adult patients who were admitted to Assiut university hospital within one year with proximal femoral fractures. Protocol of management include lines of treatment , hospital stay and results

Detailed Description
-----------------
Case series prospective study All adult patients who were admitted to AUH with proximal femoral fractures within one year. We will evaluate the real treatment protocol which was applied for those patients. Surgical procedures, as plating, Proximal Femoral Nail , Dynemic Hip screw and others procedures according to needed for each types. This epidemological study in proximal femoral fractures will provide an update on incidence, admission, hospital stay and surgical procedures. This information will assist health providers in planning hospital beds, surgical intervention, and risk prevention, moreover, this data can be use for farther clinical studies.

Official Title
-----------------
Traumatic Proximal Femoral Fractures in Adults

Conditions
-----------------
Proximal Humeral Fracture

Intervention / Treatment
-----------------
* Procedure: reduction and fixation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 1-Adult Age 2- Closed & Open fracture Exclusion Criteria: 1- Childern 2-pathological fractures

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 48 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: reduction and fixation|Surgical procedures, as plating, Proximal Femoral Nail , Dynemic Hip screw and others procedures according to needed for each types|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| • Statistical analysis for adult patients who were admitted to Assiut university hospital within one year with proximal femoral fractures | This epidemological study in proximal femoral fractures will provide an update on incidence, admission, hospital stay and surgical procedures | baseline |
Comparing the Use of Vitamin c (Ascorbic Acid) in Eye Burn in Subconjunctival Injection to Topical or Oral Treatment.

Study Overview
=================
Brief Summary
-----------------
Eye burns may cause a severe permanent damage. One kind of treatment is the use of vitamin C (Ascorbic acid). This study will compare between subconjunctival topical and/or systemic route of administration and topical and/or systemic administration.

Detailed Description
-----------------
In order to prevent permanent and severe damage to the eye after eye burn early treatment is mandatory. It is well known and published that the use of Vitamin c may contribute to the healing process of such burns, including burns from chemicals or heat. We believe that the route pf administration of the medicine is as important as the kind of medicine and that subconjunctival injection will have better effect and will influence in a favorable manner on the the end result as well as on the time of the healing. In order to be able to compare between cases we made a new definition of the severity of the burn according to the extension of the damage on the cornea, conjunctiva and limbus, and according to the severity and depth of the ischemia. In 3 medical centers 3 protocols of treatment and followup will be compared while only in Baruch Pade Medical Center the main route of administration will be subconjunctival on top of the topical treatment.

Official Title
-----------------
The Effect of Subconjunctival Vitamin c on Recovery Rate and End Result From Eye Burn.

Conditions
-----------------
Burn

Intervention / Treatment
-----------------
* Dietary Supplement: vitamin c
* Dietary Supplement: vitamin c
* Dietary Supplement: vitamin c


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Eyes clinic patients presented with acute chemical or thermal burn. Exclusion Criteria:other disease

Ages Eligible for Study
-----------------
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>Baruch Pade Medical Center | Dietary Supplement: vitamin c<br>* Subconjunctival daily or bid<br>* Other names: ascorbic acid;|
| Active Comparator: 2<br>Rambam Medical Center | Dietary Supplement: vitamin c<br>* topical and systemic<br>* Other names: ascorbic acid;|
| Active Comparator: 3<br>Soroka Medical Center | Dietary Supplement: vitamin c<br>* topical systemic<br>* Other names: burn;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| EXTENSION OF FLORSCEIN PAINT ON THE CORNEA AND CONJUNCTIVA |  | BID | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
BURN, EYE, VITAMIN C, ASCORBIC ACID
Navigation Guidance Gestures Carried Out Under CT

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to assess the contribution of navigation systems recently developed to guide the punction needle.

Official Title
-----------------
Interest of the Use of a Navigation Guidance Gestures Carried Out Under CT

Conditions
-----------------
Drainage, Biopsy, Punction

Intervention / Treatment
-----------------
* Device: navigation station


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: more or equal than 18 years old patient affiliated to social security or similarly regime patient sent to hospital for drain under CT Exclusion Criteria: Pregnant women and lactating mothers Ward of court or under guardianship Adult unable to express their consent Person deprived of freedom by judicial or administrative decision Person hospitalized without their consent Person under legal protection Person participating in another clinical study

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: navigation station|navigation station for gestures (carried out under CT) guidance|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Maximum distance between the planned trajectory and trajectory achieved, defined for the needle of local anesthesia. |  | 2 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Maximum distance between the planned trajectory and trajectory achieved by the needle puncture. |  | 2 hours | 
| Duration of intervention |  | 3 hours | 
| Dose irradiation and number of control scanners made |  | 3 hours | 
| overall satisfaction Score |  | 3 hours | 
| Success or failure of the final gesture made |  | 3 hours | 
| Number of attempts |  | 3 hours | 
| number of complications (per-operative, post-surgery) |  | 7 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
drain under scanner
Effects of Nonsteroidal Anti-inflammatory Drug (NSAID) on Inflammatory Lesion of Axial Spondyloarthritis

Study Overview
=================
Brief Summary
-----------------
Axial Spondyloarthritis (SpA) is a kind of inflammatory arthritis which includes ankylosing spondylitis. Common symptoms of axial SpA are inflammatory back pain, morning stiffness, peripheral arthritis, enthesitis. Controlling aforementioned symptoms are one of the goal in treatment, and another goal is preventing bony ankylosis of axial skeleton such as spine. Ankylosis can limit range of motion and lower the quality of life. Non-steroidal antiinflammatory drug (NSAID) and Tumor necrosis factor (TNF)-a inhibitor are the current treatment options for axial SpA. These medications can improve pain and stiffness of axial SpA patients, however preventing bony ankylosis is not proven. Current study showed attenuating inflammation at early stage could prevent further bony destruction and ankylosis in axial SpA. Present study is designed to discover the therapeutic effect of NSAID whether NSAID could recover the early inflammatory bony change (bone marrow edema at MRI) and prevent further bony change.

Official Title
-----------------
Effects of Nonsteroidal Anti-inflammatory Drug (NSAID) on Inflammatory Lesion of Axial Spondyloarthritis Results From MRI Finding

Conditions
-----------------
Spondylarthropathies, Magnetic Resonance Imaging

Intervention / Treatment
-----------------
* Drug: Celecoxib


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 2009 Assessment of SpondyloArthritis international Society (ASAS) classification criteria for axial spondyloarthritis Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) > 4 definite bone marrow edema on Sacroiliac joint MRI Exclusion Criteria: Patients who have underling cancer / infectious disease / kidney disease / liver disease / cardiovascular or cerebrovascular disease Patients who is using TNF-a inhibitor Patients with side effects of NSAID Patients with history of peptic ulcer Patients who can't keep NSAID treatment

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 30 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Sequential Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Celecoxib arm<br>Axial Spondyloarthritis patients who takes celecoxib 400mg for day | Drug: Celecoxib<br>* Continue celecoxib 400mg/day for 3months in axial spondyloarthritis patients.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Spondyloarthritis Research Consortium of Canada (SPARCC) MRI score of sacroiliac joint | Change from baseline SPARCC MRI score of sacroiliac joint at 6 weeks and 12 weeks | Baseline, 6 weeks after, 12 weeks after |