Evaluation of the Effects of Medicaments Used After Free Gingival Graft on Postoperative Complications.

Study Overview
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Brief Summary
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In our study, three different medicaments were evaluated in terms of postoperative complications after free gingival grafting (FGG).

Detailed Description
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In our study, three different medicaments were evaluated in terms of postoperative complications after free gingival grafting. The effectiveness of these 3 different commercially available agents containing flurbiprofen, hyaluronic acid, and hypochlorous acid, after use 2., 4.7. and on the 14th day, wound healing and pain perception was compared with the control group. primary observation was obtained by visual analog scale, wound healing index, bleeding of tissue, color match, and amount of painkiller used by the patient were also recorded

Official Title
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Evaluation of the Effects of Medicaments Used After Free Gingival Graft on Postoperative Complications.

Conditions
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Pain, Postoperative, Healing Wound, Hemorrhage, Analgesia

Intervention / Treatment
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* Drug: Majezik %0.25 oral spray
* Other: Aftamed oral spray
* Other: Crystalin oral spray
* Procedure: Free gingival graft harvesting


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria:- Patients with systematic conditions are classified as The American Society of Anesthesiologists Class I - Exclusion Criteria: Pregnancy, lactation, and taking contraceptive pills. Oversensitivity or anaphylactic reactions which contraindicate the intervention. Orofacial neurological symptoms. Infections at operation zone. Psychotropic medicine, sedative, or non-steroid anti-inflammatory drugs use which can alter the sense of pain. Pathological mental conditions (dementia, psychosis) and lack of cooperation. Smoking Excessive gag reflex Operations are carried out with conscious sedation. Patients who do not want to sign consent.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Control<br>Patients were not given anything after FGG. | Procedure: Free gingival graft harvesting<br>* Free gingival graft was taken from the palatal mucosa of the patients in order to increase the attached gingiva.<br>|
| Flurbiprofen<br>Oral spray containing 0.075 g flurbiprofen administered after FGG | Drug: Majezik %0.25 oral spray<br>* Free gingival graft was taken from the palatal mucosa of the patients in order to increase the attached gingiva. After FGG, the patients were asked to apply this spray to the palatal mucosa 3 times a day.<br>* Other names: Free gingival graft harvesting;Procedure: Free gingival graft harvesting<br>* Free gingival graft was taken from the palatal mucosa of the patients in order to increase the attached gingiva.<br>|
| Hypochlorous acid<br>Oral spray containing hypochlorous acid applied after FGG | Other: Crystalin oral spray<br>* Free gingival graft was taken from the palatal mucosa of the patients in order to increase the attached gingiva. After FGG, the patients were asked to apply this spray to the palatal mucosa 3 times a day.<br>* Other names: Free gingival graft harvesting;Procedure: Free gingival graft harvesting<br>* Free gingival graft was taken from the palatal mucosa of the patients in order to increase the attached gingiva.<br>|
| Hyaluronic acid<br>An oral spray containing the main component of the product is hyaluronic acid (sodium salt) with a high molecular weight of 30 mg / 100 g was given to patients after FGG | Other: Aftamed oral spray<br>* Free gingival graft was taken from the palatal mucosa of the patients in order to increase the attached gingiva. After FGG, the patients were asked to apply this spray to the palatal mucosa 3 times a day.<br>* Other names: Free gingival graft harvesting;Procedure: Free gingival graft harvesting<br>* Free gingival graft was taken from the palatal mucosa of the patients in order to increase the attached gingiva.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Landry's Wound Healing Index (WHI) | WHI was performed on the basis of postoperative healing characteristics categorized as tissue color, response to palpation, incision margins, and suppuration. | 21 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Visual Analogue Scale | Recording the pain perception of the patients on a scale from 0 to 10. 0 - no pain 10 - worst pain | 21 days | 
| Color match | scoring the color match of the healed tissue area with the patient's remaining tissue | 21 days | 
| delayed bleeding | examining the patient whether there is postoperative bleeding, if there is a positive, if not, it should be recorded as negative. | 21 days | 
| burning sensation | Evaluation of the burning sensation felt in the healing area of the patient's palate from 0 to 10. 0-no burning sensation 10- excessive burning | 21 days | 
| complete epithelization | Examination of epithelialization with 3% oxygenated water. keeping records according to the foaming rate in the tissue | 21 days |