DECT Ventilation Imaging

Study Overview
=================
Brief Summary
-----------------
Demonstrate the feasibility of dual energy computed tomography using Krypton as a gaseous contrast media in order to study the in vivo ventilation. Two different clinical situations will be tested : Prediction of postoperative pulmonary function for oncologic patients Detection of Bronchiolitis Obliterans in lung transplant recipients.

Official Title
-----------------
Quantitative Ventilation Imaging With Dual Energy Computed Tomography

Conditions
-----------------
For Oncologic Patients, Potentially Operable Lung Tumor, With a Recent (Less Than 1 Month) VQ Scan, For Lung Transplant Recipients, Single of Bilateral Lung Transplant, From 5 Months Onwards, With Recent (Less Than 1 Month) Respiratory Functional Explorations

Intervention / Treatment
-----------------
* Radiation: Single source dual energy compted tomography (CT750HD, General Electric, USA) with Krypton as a gaseous contrast media


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: For oncologic patients : Potentially operable lung tumor With a recent (less than 1 month) V/Q scan For lung transplant recipients : Single of bilateral lung transplant From 5 months onwards With recent (less than 1 month) respiratory functional explorations Exclusion criteria: Impossibility to follow simple orders or control one's respiration Known Krypton hypersensitivity History of malignant hyperthermia Increased intracranial pressure Minors Pregnant Women

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: oncologic patients<br>Prediction of postoperative pulmonary function. Patients with an operable lung cancer: dual energy computed tomography with Krypton will be tested to estimate the postoperative FEV1 | Radiation: Single source dual energy compted tomography (CT750HD, General Electric, USA) with Krypton as a gaseous contrast media<br> <br> |
| Experimental: lung transplant recipients<br>Detection of BOS 6 months+ lung transplant recipients will be tested using dual energy computed tomography with Krypton, with acquisition in the end-inspiratory and end-expiratory phase, in search of regional air trapping. | Radiation: Single source dual energy compted tomography (CT750HD, General Electric, USA) with Krypton as a gaseous contrast media<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Image quality on a qualitative 5 levels scale |  | 1 day of DECT ventilation imaging | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Radiation dose |  | 1 day of DECT ventilation imaging | 
| Image noise with measurement of signal to noise and contrast to noise ratios |  | 1 day of DECT ventilation imaging | 
| Total examination time |  | 1 day of DECT ventilation imaging |