Immune Response Following COVID-19 in Hemodialysis Patients

Study Overview
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Brief Summary
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Patients with chronic kidney disease (CKD), particularly those undergoing hemodialysis (HD), are at high risk of a severe form of COVID-19. This study aims to characterize the inflammatory and antiviral response during SarsCov2 infection in adult

Detailed Description
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Inclusion criteria were (1) Adult (>18 years old) patient on HD > 6 months, and (2) infection by SARS-CoV-2. Diagnosis of COVID-19 was assessed by Reverse-Transcriptase-Polymerase Chain Reaction (RT-PCR) for SARS-CoV-2 in nasopharyngeal swab or by typical COVID-19 radiological images on thoracic computerized tomography (CT scan). Severe forms of COVID-19 were defined as requiring oxygen therapy, admission in intensive care unit (ICU) or death Primary end point : * Characterization the cytokine's profile at the early (day 7) and inflammatory (day 14) phase of COViD-19 in HD patient Secondary End points : Analyse the kinetic of the antiviral response (type I and III interferon ) between the early (day 7) and inflammatory (day 14) phase of COViD-19. Analyse the kinetic of proinflammatory cytokine response between the early (day 7) and inflammatory (day 14) phase of COViD-19. Define an antiviral signature associated with severe form of COVID-19 Define an anti inflammatory signature associated with severe form of COVID-19 Cytokine's profile is define by the measure of 28 cytokines by Luminex technology

Official Title
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Evaluation of the Cytokine 's Profile Following SarsCov 2 Infection (COVID-19) in Hemodialysis Patients

Conditions
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Dialysis; Complications, COVID-19, Cytokine Storm

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adult (>18 years old) patient on HD > 6 months, and Infection by SARS-CoV-2. Diagnosis of COVID-19 was assessed by Reverse-Transcriptase-Polymerase Chain Reaction (RT-PCR) for SARS-CoV-2 in nasopharyngeal swab or by typical COVID-19 radiological images on thoracic computerized tomography (CT scan). The date of diagnosis was defined as the day when RT-PCR or CT-scan confirmed the diagnosis. Exclusion Criteria: Inability to give consent

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Characterization of the cytokine profile during the early phase of COVID-19 | Measurement of 29 cytokines by Luminex including type I and Type III Interferon | Measurement at Day 7 of COVID-19 | 
| Characterization of the cytokine profile during the inflammatory phase of COVID-19 | Measurement of 29 cytokines by Luminex including type I and Type III Interferon | Measurement at Day 14 of COVID-19] | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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dialysis, cytokine, COVID-19