Study of Motexafin Gadolinium and Docetaxel for Advanced Solid Tumors

Study Overview
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Brief Summary
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The primary purpose of this study is to evaluate the safety, toxicities, and dosage for investigational drug Motexafin Gadolinium administered with docetaxel to patients with advanced solid tumors. Secondly, tumor response to the combined treatment will be evaluated.

Official Title
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Phase I Trial of Motexafin Gadolinium (MGd) and Docetaxel Administered at 3-Week Intervals for Advanced Solid Tumors

Conditions
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Breast Neoplasms, Ovarian Neoplasms, Prostatic Neoplasms, Lung Neoplasms

Intervention / Treatment
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* Drug: Motexafin Gadolinium Injection


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ≥ 18 years old Histologically or cytologically confirmed diagnosis of cancer (i.e., Unresectable locally advanced or metastatic non-small-cell lung carcinoma (NSCLC) that had progressed during or after one or more chemotherapy regimens; Metastatic breast cancer; Hormone-refractory prostate cancer; Recurrent or refractory ovarian cancer; Sarcoma) ECOG performance status score either 0 or 1 Willing and able to provide written informed consent Exclusion Criteria: Laboratory Values of: Absolute neutrophil count < 2000/µL Platelet count < 100,00/µL AST or ALT > 1.5 x the upper limit of normal Alkaline phosphatase > 5 x the upper limit of normal Bilirubin > ULN Creatinine > 2.0 mg/dL and Peripheral neuropathy NCI CTC Grade 3 or higher Chemotherapy, radiation therapy, immunotherapy, or systemic biologic anticancer therapy within 21 days before beginning study treatment Known history of brain metastases or spinal cord compression Uncontrolled hypertension Myocardial infarction within 6 months before beginning study treatment Unstable angina pectoris, uncontrolled congestive heart failure, or uncontrolled serious arrhythmias Known sensitivity to or intolerable adverse effects from taxanes or polysorbate 80 Known history of porphyria (testing not required at screening) Known history of glucose-6-phosphate dehydrogenase (G6PD) deficiency (testing not required at screening) Known history of HIV infection (testing not required at screening) Female who is pregnant or lactating (pregnancy test is required for all female patients of childbearing potential) Female of childbearing potential or sexually active male unwilling to use adequate contraceptive protection Physical or mental condition that makes patient unable to complete specified follow-up assessments

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Motexafin Gadolinium Injection|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Determine the Dose Limiting Toxicity at 3 weeks (1 cycle), and the Maximum Tolerated Dose at 24 weeks (6 cycles). |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Frequency of tumor responses at weeks 6, 12 and 18. |  |  | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Antineoplastic Combined Chemotherapy Protocols