The PROspective German NOn-CF bronchiectaSIS Patient Registry

Study Overview
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Brief Summary
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The purpose of this study is to study the epidemiology of non-CF bronchiectasis (NCFB) and to provide an estimate of the distribution (prevalence) of NCFB etiologies across all different levels of health care as well as real-life data regarding the current management of NCFB in Germany.

Detailed Description
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To study the epidemiology of non-CF bronchiectasis (NCFB) and to provide an estimate of the distribution (prevalence) of NCFB etiologies across all different levels of health care as well as real-life data regarding the current management of NCFB in Germany To establish feasible investigational strategies in order to establish the etiology of NCFB To perform observational research into bronchiectasis, particularly in areas where single center datasets are underpowered, such as in rare etiologies or determining markers of prognosis To promote collaborative clinical, basic and translational research in NCFB between German (and European) centers To provide a registry of well phenotyped patients with NCFB in clinical centers potentially eligible for enrolment into clinical trials To track access to healthcare and cost of caring for patients with NCFB over time

Official Title
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The PROspective German NOn-CF bronchiectaSIS Patient Registry

Conditions
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Bronchiectasis

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: A clinical history consistent with bronchiectasis (High resolution) computed tomography (CT) scan of the chest demonstrating bronchiectasis affecting 1 or more lobes Exclusion Criteria: Bronchiectasis due to known cystic fibrosis (CF) Age <18 years Interstitial lung disease Prior lung or heart-lung transplantation

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of participants with non-CF bronchiectasis (NCFB) across all different levels of health care regarding the current management of NCFB in Germany | To establish a national, representative, prospective, observational and longitudinal NCFB database and collaborative research network with a database including a minimum of 750 patients from a minimum of 25 centers from all levels of healthcare across Germany after a period of 3 years. | three years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prevalence of non-CF bronchiectasis (NCFB) etiologies (composite outcome measures) across all different levels of health care | Distribution (prevalence) of underlying conditions/etiologies Clinical presentation of NCFB Predictors of lung function decline in patients with NCFB Diagnostics employed in determining the etiology of NCFB Microbiology of NCFB Radiology of NCFB Comorbidity in patients with NCFB Impact of exacerbations and hospitalizations on the clinical course of NCFB Prescription patterns of pharmacological respiratory treatments for NCFB Usage and benefit of surgical procedures in NCFB Physical therapy and rehabilitation Healthcare utilization and associated costs in NCFB QOL(Questions of Life) among patients with NCFB survival/mortality of NCFB | three years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Prognosis, Prospective Study, Quality of Life, Radiology, Rehabilitation, Registry;, Signs and Symptoms, Therapy, Bronchiectiasis, Diagnosis, Epidemiology, Etiology, Longitudinal Study, Microbiology