Quadratus Lumborum Block : Effect on Acute Pain and Quality of Recovery After Laparoscopic Adrenalectomy

Study Overview
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Brief Summary
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This prospective, randomized ,control study aims to compare the analgesic effect,quality of recovery, length of hospital stay ,et al. between single-injection QLB(quadratus lumborum block)+general anesthesia (GA) and general anesthesia (GA) alone in patients undergoing laparoscopic adrenalectomy.

Official Title
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Quadratus Lumborum Block : Effect on Acute Pain and Quality of Recovery After Laparoscopic Adrenalectomy

Conditions
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Pain Management, Nerve Block, Laparoscopic Adrenalectomy

Intervention / Treatment
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* Procedure: single-injection QLB(quadratus lumborum block)
* Procedure: Placebo control


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 18-70 yrs American Society of Anesthesiologists physical statusⅠ-Ⅲ Undergo laparoscopic adrenalectomy Informed consent Exclusion Criteria: A known allergy to the drugs being used Coagulopathy, on anticoagulants Analgesics intake, history of substance abuse Participating in the investigation of another experimental agent Inability to properly describe postoperative pain to investigators (eg, language barrier, neuropsychiatric disorder)

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: single-injection QLB(quadratus lumborum block)<br>Single-injection of QLB with local anesthetic is given preoperatively | Procedure: single-injection QLB(quadratus lumborum block)<br>* Inject 0.4ml/kg 0.5% ropivacaine between quadratus lumborum and psoas major without continuous local infusion Device: Ultrasound Scanner The curved (C1-5) probe of Ultrasound Scanner is used for scan Device: PAJUNK StimuLong Drug: single dose ropivacaine 0.4ml/kg 0.5% ropivacaine given immediately after the correct position of the tip of the needle has been verified.<br>|
| Placebo Comparator: Placebo control<br>Single-injection of QLB with NS is given preoperatively | Procedure: Placebo control<br>* Inject 0.4ml/kg saline between quadratus lumborum and psoas major without continuous local infusion Device: Ultrasound Scanner The curved (C1-5) probe of Ultrasound Scanner is used for scan Device: PAJUNK StimuLong Drug: single dose 0.4ml/kg 0.9% NS. given immediately after the correct position of the tip of the needle has been verified.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| pain numeric rating scale (NRS, 0-10)pain score at activity at 12 hours after surgery |  | At 12hours after the surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The pain scores at rest determined by the numeric rating scale (NRS, 0-10) |  | At 2,4, 8, 12,24 ,48,72hours after the surgery | 
| incidence of postoperative nausea and vomiting (PONV) |  | within 24 postoperative hours | 
| ambulation time |  | within5 days after surgery | 
| time of restart anal exhaust |  | within 5 days after surgery | 
| Postoperative length of hospital stay |  | up to2 weeks after surgery | 
| patient's satisfaction with anesthesia and analgesia | use the Chinese version Bauer questionnaire to assess the patient satisfaction with anesthesia and analgesia | 48 hours after surgery | 
| The pain scores at activity determined by the numeric rating scale (NRS, 0-10) |  | At 2,4, 8, 24 ,48,72hours after the surgery |