2nd_Computerized Asthma Specific Quality of Life(cAQOL)

Study Overview
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Brief Summary
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Comparison of the responsiveness of two different asthma-specific QOL measures (AQLQ and cAQOL) in Korean patients with persistent asthma

Official Title
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Comparison of the Responsiveness of Two Different Asthma-specific QOL Measures (AQLQ and cAQOL) in Korean Patients With Persistent Asthma

Conditions
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Persistent Asthma Patient

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient aged 20-70 years Patient diagnosed with asthma over six months ago Asthma diagnosis Airway reversibility, FEV1 ≥ 12% and 200mL or Airway hyper-responsiveness, PC20 < 16 mg/mL or More than two weeks, more than 2 times a day in excess of 20% PEFR diurnal variability patient FEV1 55-100% of predicted value patient Inhaled corticosteroids alone or inhaled corticosteroids and beta agonists used patient Currently, at least if you have one or more asthma symptoms, asthma control test (ACT • Asthma Control Test) score of less than 19 characters Patients who sufficiently listen to the purpose and content of this trial and the properties of investigational products and voluntarily agree with the participation to sign a written consent approved by IRB of Ajou University Medical Center before the participation in this trial Exclusion Criteria: Current smoking or smoking in the past 15packyears Patients who show a symptom of an acute disease within 14 days before the beginning of this trial (administration of trial medication) Recent changes in asthma treatment for 28days Chronic diseases that affect the quality of life

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>Asthma control test check AQLQ(Asthma Quality of Life Questionnaire)after being cAQOL(Computerized Asthma specific quality of life) | |
| 2<br>Asthma control test check cAQOL(Computerized Asthma specific quality of life)after being AQLQ(Asthma Quality of Life Questionnaire) | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Two asthma quality of life measurement tool | Two asthma quality of life measurement tool (cAQOL, AQLQ) and the correlation between ACT | 24 weeks treatment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between cAQOL/AQLQ | -Correlation between cAQOL/AQLQ and other clinical parameters including FEV1, and asthma exacerbation. | treatment screening, week1,week12,week24 | 
| Association of asthma control therapy and a questionnaire | -The proportion of subjects with achieving well controlled asthma within ACT & cAQOL-guided management strategy with ICS or ICS/LABA based on GINA 2006 guidelines during 24 weeks. | 24 weeks treatment | 
| asthma patient genotypes | Sub-group of ADRB2 and NK2R genotypes | Screening | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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AQLQ and cAQOL