FACEFI : Cardiac Fatigue During Intense Exercises - Pilot Study

Study Overview
=================
Brief Summary
-----------------
To attest if a cardiac fatigue appears (and to measure it if it does) during intense physical exercises in two groups of subjects: Canoeists from a training center of the French canoeing team during an intensive session of three weeks of endurance training; Young recruits in military school of officers in ground forces of the French army during an intensive.

Official Title
-----------------
FACEFI : Cardiac Fatigue During Intense Exercises - Pilot Study

Conditions
-----------------
Muscle; Fatigue, Heart

Intervention / Treatment
-----------------
* Procedure: Tests


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy men between 18 and 35 years old; Giving their writing informed consent; And affiliated to the French social security. Exclusion Criteria: To be a smoker. To present any known pathology that forbids the realisation of any test, or that can alter the measurements: cardiovascular risk factors treated or not (diabetes, dyslipidaemia, arterial hypertension, obesity), cardiac arrhythmia, coronary disease, heart failure, cardiac pacemaker or defibrillator, valvular disease after surgery or not, kidneys failure with dialyse or not, kidney pulmonary cardiac or liver transplantation, chronic bronchopneumopathy, asthma, etc. To take any medication that could alter autonomic nervous system or cardiovascular adaptation to maximal exercise (anti-arrhythmia, anti-hypertensive, anti-inflammatory,…). Drinking exciting drinks (coffee or tee for example) in the 12h before the tests. To be under legal protection (trusteeship, guardianship) or to be deprived of liberty.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Canoeists<br>13 canoeists from a training center of the French canoeing team | Procedure: Tests<br>* Individual parameters of echocardiography and heart rate variability<br>|
| Experimental: Military<br>10 young recruits in military school of officers in ground forces of the French army | Procedure: Tests<br>* Individual parameters of echocardiography and heart rate variability<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measure of classical echocardiographic parameters to attest systolic and diastolic functions | Speckle tracking will also be used to get strain parameters of the left ventricle. Measure will by recording daily before, during, and after a period of intensive training, in order to attest possible cardiovascular effects of such periods. Echocardiographic data will be recorded at rest and during a submaximal exercise. | day 8 (canoeists) / day 5 (military) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measure of classical heart rate variability parameters | Measure will by recording daily before, during, and after a period of intensive training, in order to attest possible cardiovascular effects of such periods. Measure will be recorded during 5 min resting and 5 min standing. | day 8 (canoeists) / day 5 (military) | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Senior athletes, Cardiac functions, Endurance training