Effects of Total Intravenous Anesthesia With Propofol-remifentanil Versus Inhalational Anesthesia With Sevoflurane on Quality of Recovery in Patients Undergoing Transsphenoidal Surgery for Pituitary Tumor

Study Overview
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Brief Summary
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A number of studies have compared the effects of total intravenous anesthesia(TIVA) versus inhalational anesthesia on perioperative period during transsphenoidal surgery. However, they have limitations especially for the phase of recovery after anesthesia: a fragmentary assessment. Quality of Recovery 40 (QoR-40) questionnaire was multi-dimensionally designed to assess the degree of recovery, specially after anesthesia and surgery. In this study, the investigators aim to compare the quality of recovery after inhalational anesthesia and after TIVA through QoR-40 questionnaire in patients undergoing transsphenoidal surgery for pituitary tumor under general anesthesia.

Conditions
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Pituitary Tumor

Intervention / Treatment
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* Drug: total intravenous anesthesia (TIVA)
* Drug: inhalation anesthesia group


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients over age 19 Scheduled to undergo transsphenoidal surgery for pituitary tumor ASA class I and II Exclusion Criteria: Left ventricular ejection fraction < 55% Third-degree atrioventricular block Second-degree atrioventricular block (P:QRS ratio of 3:1 or higher) Fever History of myocardial infarction, stroke or cardiac surgery within the previous 1 year Severe neurological disease Use of sedative, opioid or sleep-inducing drugs Allergic history of any study drug Pregnancy

Ages Eligible for Study
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Minimum Age: 19 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: TIVA group<br>Anesthesia is maintained with propofol during surgery | Drug: total intravenous anesthesia (TIVA)<br>* In the TIVA group,anesthesia is induced and maintained by effect-site target controlled infusion of propofol and remifentanil.<br>|
| Active Comparator: inhalation anesthesia group<br>Anesthesia is maintained with sevoflurane during surgery | Drug: inhalation anesthesia group<br>* In the inhalation anesthesia group, anesthesia is induced by pentothal sodium 4-6mg/kg and remifentanil 1 μg/kg, and then maintained with end-tidal sevoflurane concentration of 0.8 to 1 MAC and continuous infusion of remifentanil at 0.1-0.3μg/kg/min.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| QoR-40 score | We compare the QoR-40 scores of two groups 1 day after the operation. | 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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anesthesia, intravenous, neurosurgery, pituitary neoplasm, postoperative period