The Effect of Aronia Melanocarpa Extract on Cognitive Function

Study Overview
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Brief Summary
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There is a great interest in improving cognitive performance, including memory and attention. Improved attention is desirable for a large group of people because it is linked to improved performance . Students and professionals can benefit from improved attention and thus performance in academic and other work environments. In addition, cognitive functioning also plays an important role in sports. Various cognitive skills, including attention, reaction time and motor function, have shown that they can influence sport performance. A completely natural supplement with aronia melanocarpa extract could be a promising way to naturally improve cognitive performance.

Detailed Description
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There is a great interest in improving cognitive performance, including memory and attention. Improved attention is desirable for a large group of people because it is linked to improved performance. Students and professionals can benefit from improved attention and thus performance in academic and other work environments. In addition, cognitive functioning also plays an important role in sports. Various cognitive skills, including attention, reaction time and motor function, have shown that they can influence sport performance. A completely natural supplement with aronia melanocarpa extract could be a promising way to naturally improve cognitive performance. The product in this study is aronia melanocarpa which contains polyphenols. A limited number of clinical studies have already been carried out to see the effect of similar products on cognitive functioning. However, these studies have often been done in older study populations or over a longer period of time. In this study, in healthy adolescents (ages between the 18-35 and with a BMI between 18.5 and 30), the investigators want to test the short term (7 days) effect of aronia melanocarpa extract on cognitive functioning. The investigators will also test the effect of supplementation on the particpant's mood, vascular function, blood biomarkers, retinal vasculature, and subjective cognition.

Official Title
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The Effect of Short-term Aronia Melanocarpa Extract Supplementation on Cognitive Function in Healthy Young Adults

Conditions
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Cognitive Function

Intervention / Treatment
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* Dietary Supplement: Aronia
* Dietary Supplement: Placebo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy young adults: ages between 18 and 35 BM between 18.5-30 kg/m2 Exclusion Criteria: Current use of (antioxidant) dietary supplements and not willing to quit for the duration of the study duration Pre-existing or history of neurological illness High blood pressure (>140 systolic and/or >90 diastolic mmHg) Use of medication that might have influence on endpoints (e.g. antidepressant) Known pregnancy or lactation Food allergy to the study product Administration of investigational drugs or participation in any scientific intervention study which may interfere with this study, to be decided by the principle investigator, in the 180 days prior to the study Abuse of products (> 20 alcoholic consumptions per week and drug usage) Participation in a scientific intervention study which may interfere with this study in the 180 days prior to this study

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Crossover Assignment
Interventional Model Description: Cross-over study with 2 intervention conditions
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: placebo<br>microcrystalline cellulose supplementation | Dietary Supplement: Placebo<br>* daily supplementation<br>|
| Experimental: Aronia<br>aronia melanocarpa supplementation | Dietary Supplement: Aronia<br>* daily supplementation<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cognitive function | CANTAB | After 7 days of supplementation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mood | VAMS | After 7 days of supplementation | 
| Biomarkers in blood and saliva | BDNF & cortisol | After 7 days of supplementation | 
| Vascular function | SBP & DBP, PWA & PWV | After 7 days of supplementation | 
| Microvasculature | Fundus photography | After 7 days of supplementation | 
| Subjective cognition | Cognitive Failures Questionnaire | After 7 days of supplementation | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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supplementation, cognition, cognitive function, vascular function, microvasculature