Sensory Properties of Bowel Cleansing Solutions

Study Overview
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Brief Summary
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Samples of 4 commercially available bowel cleansing solutions, namely PEG-electrolyte + ascorbic acid (PEG-Asc, Moviprep®, Norgine, UK), PEG-electrolyte (PEG, Fortrans® Ibsen, France), sodium picosulfate/magnesium citrate (SPS, Picoprep®, Ferring, Switzerland), and oral sodium sulfate (OSS, Izinova®, Ibsen, France) were prepared according to the manufacturer's instructions. Descriptive analysis was conducted with trained panelists (N= 14) to create a sensory profile for the solutions and generated attributes were rated on an unstructured 15-cm line scale using the Compusense at-hand® (Guelph, Canada) sensory evaluation software. Acceptability testing was carried out with untrained participants (N=80) and samples were rated on the 9-point hedonic scale. Moreover, a Just-About-Right (JAR) scale was included for the four basic tastes to determine their compatibility with optimum taste/acceptability levels in the products.

Official Title
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Sensory Evaluation of Laxative Bowel Solutions Used Prior to Colonoscopy

Conditions
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Laxative Bowel Cleansing Solutions

Intervention / Treatment
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* Behavioral: Descriptive analysis
* Behavioral: acceptability test


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age between 18 and 50 years Exclusion Criteria: allergies to polyethelene glycol (PEG), artificial sweeteners

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Descriptive analysis<br>panelists were asked to rate different sensory attributes for different laxative bowel cleansing solutions on a 15 cm line scale. | Behavioral: Descriptive analysis<br>* subjects were asked to assess the sensory profile by tasting the laxative bowel cleansing solutions, namely: Moviprep, picoprep, fortrans and isinova<br>|
| Other: Acceptability test<br>panelists were asked to rate the acceptability of different laxative bowel cleansing solutions using the 9-point hedonic scale. | Behavioral: acceptability test<br>* subjects were asked to assess the acceptability of the laxative bowel cleansing solutions, namely: Moviprep, picoprep, fortrans and isinova<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| rating of sensory attributes | participants attended 4 training sessions during which they generated sensory descriptive attributes specific for the tasted laxative solutions. In addition, they evaluated the laxative samples by rating generated attributes on a 15-cm unstructured line scale using compusense at-hand sensory evaluation software. | 3 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Acceptability Score | untrained participants evaluated the laxative samples for acceptability testing using the 9-point hedonic scale. | 1 week | 
| Just about right score | Participants evaluated the laxative samples for the 4 basic tastes (saltiness, sourness, sweetness and bitterness) to determine their compatibility with optimum taste levels in the products. | 1 week | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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laxatives, sensory evaluation, acceptability, colonoscopy