linjc16/ctgov huggingface dataset:
Effects of Respiratory Physiotherapy in Critically Ill Patients Ventilated for More Than 48 Hours

Study Overview
=================
Brief Summary
-----------------
This study aimed to determine the impact of providing chest physiotherapy on the duration of mechanical ventilation, intensive care length of stay, intensive care and hospital mortality in mechanically ventilated patients.

Conditions
-----------------
Mechanical Ventilation

Intervention / Treatment
-----------------
* Procedure: Chest physiotherapy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients aged more than 18 years, admitted to the ICU needing mechanical ventilation for longer than 48 hours Exclusion Criteria: Patients with ventilatory failure due to neuromuscular dysfunction

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Physiotherpy<br> | Procedure: Chest physiotherapy<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| intensive care mortality |  |  | 
| 120-day mortality |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| duration of mechanical ventilation |  |  | 
| intensive care length of stay |  |  |
Assessment of the Number of Umbilical Cord Vessels at the Time of Nuchal Translucency Screening

Study Overview
=================
Brief Summary
-----------------
The primary objective of this study is to determine the detection rate of two- or three-vessel umbilical cord at the time of nuchal translucency screening between 11 and 13 6/7 weeks gestation. Hypothesis: Detection rate of the number of vessels during first trimester will be as accurate as the detection of vessels during the second trimester.

Official Title
-----------------
Assessment of the Number of Umbilical Cord Vessels at the Time of Nuchal Translucency Screening

Conditions
-----------------
Umbilical Cord

Intervention / Treatment
-----------------
* Procedure: Doppler ultrasound


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Singleton or multiple-gestation pregnancies in patients presenting for NT screening between 11 and 13 6/7 weeks gestation and CRL between 45-84mm as determined at the time of the ultrasound Age 18 and older Exclusion Criteria: Patients who are incapable of informed consent or minors

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Doppler ultrasound|Ultrasound using Doppler mode to detect blood flow in umbilical cord vasculature and determine the number of vessels present|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Detection of the number of vessels in the umbilical cord between 11 and 13 6/7 weeks. |  | 11-13+6 weeks | 
| Detection of the number of vessels in the umbilical cord between 18 and 23 6/7 weeks. |  | 18 - 23 6/7 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sensitivity and specificity of transabdominal sonography at detecting vasculature of the cord between 11 and 13 6/7 weeks. |  | 11-13+6 weeks gestational age | 
| Sensitivity and specificity of transabdominal sonography at detecting vasculature of the cord during the second trimester. |  | 18-24 weeks gestation | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
ultrasound, first trimester, umbilical cord
Capnography During Colonoscopy

Study Overview
=================
Brief Summary
-----------------
In the study the value of capnography for avoiding complications during sedation for colonoscopy is evaluated.

Detailed Description
-----------------
In this randomized controlled trial the utility of capnography gets evaluated. Hypoxemia may occur during sedation with midazolam and propofol. Whether hypoxemia may be prevented by an additional capnographic monitoring is subject of the study.

Official Title
-----------------
Capnography as an Adjunct to Standard Monitoring During Midazolam and Propofol Sedation for Colonoscopy

Conditions
-----------------
Hypoxemia, Complications

Intervention / Treatment
-----------------
* Procedure: Capnography


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age>=18 Scheduled for colonoscopy with midazolam and propofol sedation Exclusion Criteria: No informed consent ASA IV or V Pregnancy Prexisting hypotension, bradycardia or hypoxemia

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Capnography<br>Arm with capnographic monitoring | Procedure: Capnography<br>* Monitoring of the capnography curve for early detection of apnea<br>|
| No Intervention: Standard<br>Standard monitoring. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hypoxemia |  | From the start to the end of colonoscopy, i.e. from 0 h to approximately 2 h | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Further complications |  | From the start to the end of colonoscopy, i.e. from 0 h to approximately 2 h | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Safety, Sedation, Gastrointestinal endoscopy, Colonoscopy
Micrometastasis in Gastrointestinal Cancer

Study Overview
=================
Brief Summary
-----------------
Prognostic and predictive value of assessing the patients micrometastasis status in blood and bone marrow when diagnosed GI cancer. 2 different patient subgroups are currently studied, patients with cancer of the pancreas and patients with liver metastasis secondary to colorectal cancer. Our hypothesis is that patients with detective circulating tumor cells in the blood or disseminated tumour cells in their bone marrow at diagnosis have a more advanced disease than negative patients. This information may be of therapeutic interest.

Detailed Description
-----------------
Oncological and overall outcome of the included patients are consecutively registrated at the out-patient clinic. At end of follow-up these survival data are analysed according to the presence of tumor cells in blood and bone marrow, and the prognostic impact of their presence are assessed.

Official Title
-----------------
The Process of Metastasis in Colorectal Cancer Tumour Biology and Prognostic Factors in Pancreatic Cancer

Conditions
-----------------
Pancreatic Adenocarcinoma, Colorectal Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Histological proven adenocarcinoma of the pancreas Histological/radiological verified colorectal liver metastases Consent capable patient Signed written, informed consent Exclusion Criteria: 1. Patient'history of other malignancy
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Gastrointestinal cancer patients<br>Patients with radiological suspected cancer in the pancreas Patients with radiological suspected colorectal liver metastasis | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Survival |  | 5 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
survival
NIRS and Doppler to Predict NEC in Risk Neonates

Study Overview
=================
Brief Summary
-----------------
The main objective is to evaluate the interest of cerebro-splanchnic oxygenation ratio (CSOR) for early diagnosis of necrotizing enterocolitis (NEC) in neonates with rectal bleeding and/or abdominal distension. CSOR will be determined using near infrared spectroscopy (NIRS).

Official Title
-----------------
Assessment of Splanchnic Oxygenation and Circulation in Neonates at Risk for Necrotizing Enterocolitis Using NIRS and Doppler

Conditions
-----------------
Necrotizing Enterolitis

Intervention / Treatment
-----------------
* Device: Cerebral and splanchnic ear infrared spectroscopy (NIRS) and mesenteric Doppler


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: less than 28 days neonates hospitalised in neonatology care unit presenting rectal bledding and/or abdominal distension signed authorization by the parents (consent form) Exclusion Criteria: - cutaneous lesions in the regions of monitoring emergency for NEC

Ages Eligible for Study
-----------------
Maximum Age: 28 Days

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: newborn suspected to suffer from necrotizing enterolitis<br>Cerebral and splanchnic ear infrared spectroscopy (NIRS) and mesenteric Doppler | Device: Cerebral and splanchnic ear infrared spectroscopy (NIRS) and mesenteric Doppler<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cerebro-splanchnic oxygenation ratio | NIRS assessment | up to 48h | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mesenteric Doppler flow |  | up to 48h | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
rectal bleeding, necrotizing enterolitis, splanchnic oxygenation, mesenteric doppler
Probing Neural Circuitry for the Control of Movement

Study Overview
=================
Brief Summary
-----------------
The investigators are interested in examining 1) the basic organization of spinal and cortical circuitry for the control of movement and 2) the influence of injury of these circuits. To investigate the neuronal circuitry, the investigators use various types of mechanical or electrical stimulation of the limbs, transcranial magnetic stimulation of the cortex and galvanic vestibular stimulation in both uninjured human subjects and subjects with a neurological injury (such as spinal cord injury, or Parkinsons's disease).

Conditions
-----------------
Neurological Movement Disorders

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: control subjects: no neurological movement disorder patients: neurological movement disorder Exclusion Criteria: patients and control subjects: presence of any central psychiatric disorder that precludes subject from giving informed and voluntary consent presence of any cardiovascular conditions or limitations that restrict the ability to walk on a treadmill continuously for more than 20 minutes for the electrical stimulation examination, subjects with metal implants are also excluded for the TMS and GVS examination, subjects with the following conditions are excluded: metal implants in the head, cardiac pacemakers, history of migraine headaches, history of major head injury, history of stroke, history of seizures, previous brain neurosurgery, unstable medical conditions, major psychiatric disorders, pregnancy -

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Neurological Injury<br> | |
| No Neurological Injury<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Spinal reflex activity | Spinal reflex activity will be assessed by electrical nerve stimulation | one day |
Risk Factors of Cat Scratch Colon Developing.

Study Overview
=================
Brief Summary
-----------------
This study was designed to: estimate the incidence of cat scratch colon in the investigators environment; explore the diseases associated to its development; identify the factors related to its development; and assess its clinical repercussions.

Detailed Description
-----------------
All of the ambulatory colonoscopies performed at the investigators University Hospital from September 2007 were prospectively included in the study. Data recorded for each patient included: age, sex, disease background, reason for the examination, hematological data and the endoscopic diagnosis. Every patient presenting CSC lesions had colon biopsies taken. These were studied by a single anatomic pathologist specializing in gastrointestinal pathologies. The characteristics (age, sex, disease background, indication for surgery, age at the time of surgery, time elapsed since surgery, hematological data and pathoanatomical study of the colon biopsies) of diversion colitis patients with and without CSC lesions will bi compared.

Official Title
-----------------
Risk Factors of Cat Scratch Colon Developing.

Conditions
-----------------
Mucosal Erosion

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All of the ambulatory colonoscopies performed at our University Hospita Exclusion Criteria: Patients thats refused.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cat Scratch Colon<br>Patients with mucosal tears during colonoscopy | |
| Control group<br>Patients without mucosal tears during the colonoscopy | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Presence of cat scratch colon during the endoscopy | Cat Scratch Colon: spontaneous tears appearing in the colon mucosa during colonoscopy | at the moment of colonoscopy | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Cat Scratch Colon., Mucosal tears., Mucosal erosion., Colonoscopy.
Clinical Evaluation of a Wearable Sleep Diagnosis Technology

Study Overview
=================
Brief Summary
-----------------
The primary endpoint is to evaluate the sensitivities and specificities for diagnosis of sleep apnoea of a wearable sleep diagnosis technology vs. existing gold standard.

Detailed Description
-----------------
The clinical investigation will be performed at the Royal Free London Hospital. Physiological signals will be pseudo-anonymized and only viewed by the research team. The Study will involve patients who will have been referred for diagnosis of sleep apnoea, will aim to determine AcuPebble's positive and negative predictive ratios, sensitivities as specificities. Likelihood ratios for diagnosis of sleep apnoea. Clinical experts will determine patients' diagnostic information using the current diagnostic standards. AcuPebble will also generate diagnostic results independently and automatically. Both set of results will be subsequently compared and the relevant performance metrics listed above will be determined. Consecutive patients referred for sleep study will be recruited to the study. Patients that are willing to participate will be consented on the day of their sleep study and sent home with both - the Trusts usual multichannel polygraphy and the Acupebble.

Official Title
-----------------
Clinical Evaluation of a Wearable Sleep Diagnosis Technology

Conditions
-----------------
Obstructive Sleep Apnea

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients who have been referred to a sleep clinic due to suspicion of sleep apnoea. Exclusion Criteria: Age under 18 or over 70 years. Subjects who are not fluent in English, or who have special communication needs. Known allergy to the adhesive dressing. Subjects with physical or mental impairments who would not be able to use the new technology on their own. Subjects with very loose/saggy skin in the neck area which would unavoidably result on - AcuPebble swinging if moving the neck. Subjects with pacemakers. exclude patients who have any type of implanted electronic devices (these include patients in ICDs and left ventricular assist devices and loop recorders).

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| test group<br>First group is the first 10 patients | |
| study group<br>following 150 patients | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sensitivities and Specificities for diagnosis of sleep apnoea studies | Sensitivities and Specificities for diagnosis of sleep apnoea studies | 6 months |
Hull Airway Reflux Questionnaire Scores Following Cough Treatment

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to have those patients taking part in the Clinical trial-: A Multicentre, Double-Blind, Placebo-Controlled, Pivotal Study of the Efficacy and Safety of Oral Theobromine in the Management of Cough. Complete the Hull Airway Reflux Questionnaire (HARQ) at randomisation and repeat the questionnaire at the end of the 14 day treatment period. The investigators hope to demonstrate a clinically significant change in HARQ scores of at least 16 points from before and after treatment. Furthermore the investigators would hope to show a significantly improved HARQ score in patients on the BC036 arm of the study compared to the placebo arm.

Official Title
-----------------
Supplementary Study of Hull Airway Reflux Questionnaire Scores Before and After Treatment Study: A Multicentre, Double-Blind, Placebo-Controlled, Pivotal Study of the Efficacy and Safety of Oral Theobromine in the Management of Cough.

Conditions
-----------------
Cough

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Male/females meeting eligibility criteria for study: - A Multi-centre, Double-Blind, Placebo-Controlled, Pivotal Study of the Efficacy and Safety of Oral BC1036 in the Management of Cough. Willing and able to comply with study procedures Able to provide written informed consent to participate Exclusion Criteria: 1. Any subject meeting any exclusion criteria on the study A Multi-centre, Double-Blind, Placebo-Controlled, Pivotal Study of the Efficacy and Safety of Oral BC1036 in the Management of Cough. Will be excluded from this study.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Chronic cough<br>Patients taking part in supplementary study must be randomised to main study which includes a placebo arm and treatment arm | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hull Airway Reflux Questionnaire score | The primary objective is to evaluate the effectiveness of HARQ in measuring a clinically significant change in HARQ score from baseline following 14 days treatment. | baseline and 2 weeks later | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| HARQ SCORES | The Key secondary endpoint will be to evaluate ability of HARQ in demonstrating a clinically significant change in score from baseline in the BC036 arm compared to Placebo arm of main study. | baseline and 14 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
chronic cough