Double Blind Randomized, Monocentric, Cross-over, Placebo-controlled Study to Evaluate the Effect of Citalopram on Motivation

Study Overview
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Brief Summary
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The aim of the current study is to examine the role of serotonin on the cognitive parameters of motivation. They are embedded in a conceptual framework of motivation that merges decision-making and reinforcement learning theories. Every action is conceived as path from one state to another. The different states are associated to different values (positive for rewards and negative for punishments), and the different actions to different costs (risk, effort and delay). The tasks are designed such that the sensitivity to the state and action parameters can be inferred by fitting computational models.The primary objective is to characterize the effect of Citalopram 30mg on reward sensitivity, assessed in an incentive force task, in which participants are asked to squeeze a hand grip to win monetary rewards. Secondary objectives are to characterize the effect of Citalopram 30mg on other cognitive parameters of motivation (assessed with a motivational battery that includes rating, choice and learning tasks).

Official Title
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Etude Comparative Monocentrique, randomisée, en Cross-over, en Double Aveugle, Contre Placebo, de l'Action du Citalopram Sur Les paramètres Cognitifs de la Motivation

Conditions
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Normal Volunteers

Intervention / Treatment
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* Drug: Citalopram 30mg


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Man or woman, age ≥ 18 and < 50 Weight between 50 kg and 90 kg. No contraindication to effort No evolutive pathology that could interfere with the current study signed consent medical insurance (sécurité sociale) Exclusion Criteria: Age < 18 or > 50 Smokers Person under curatorship, or guardianship, or with civil rights deprivation History of neurologic or psychiatric pathology Presence of any psychotropic treatment Chronic or actual consumption of alcohol, or psychotropic drugs pregnancy, breastfeeding Woman of childbearing potential without effective contraception Hypersensitivity to atomoxetine or other constituents of the product Pheochromocytoma Narrow angle Glaucoma Liver failure Severe Cardiovascular Disorders Severe Cerebrovascular Discorders Treatment with non-selective Monoamine Oxidase Inhibitor (MAOI) : iproniazide. Treatment with Linezoline, Lithium, Milleperthuis, Tramadol, tryptans. Treatment with Pimozide, or treatment that can induce a QT prolongation (neuroleptics, class IA and III antiarrythmic, moxifloxacine, erythromicine, methadone, mefloquine, tricyclic antidepressants, lithium, cisapride), or treatment that can induce an hydroelectrolytic inbalance (thiazide diuretics). Treatment with Anticoagulants Treatment that can decrease seizure threshold: antidepressants, neuroleptics, mefloquine, buproprione, tramadol Enzyme inducers, (rifampicine, …) Treatment that can interfere with the performance of the subject: beta2 adrenergic agonists, analgesics, corticosteroïds, anti-inflammatory drugs, …

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Intervention Model: Crossover Assignment
Masking: Triple


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Citalopram 30mg|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Reward sensitivity | Apathy will be assessed as the sensitivity to rewards in an incentive force task. The primary Outcome measure is the change in this parameter between the placebo condition and the Citalopram condition. | Multiple Time Frame: 2h after placebo, 2h after Citalopram 30mg |