Conflict Detection Development During the Reasoning

Study Overview
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Brief Summary
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The study to explore the development of these abilities with age, and called Development of the conflict detection during the reasoning - Decor will take place at CYCERON center and will include two groups of 22 participants: adolescents and young adults (N = 44). More specifically, this study aims to compare the changes in the brain of adolescents and young adults when conducting reasoning tasks for which there may be a cognitive conflict. Both groups of participants then spend an MRI (Magnetic Resonance Imaging) focused on the brain and in which they will carry out two classic tasks covering the main areas of reasoning (probabilistic and economic). Each of these tasks will be manipulated to include, or not, of making information call intuition to create or not a conflict between the correct answer (logic, normative) and biased response (intuitive, heuristic). Because of the major implication of this brain region in cognitive inhibition processes [of intuitive answer], measured brain activity in the anterior cingulate cortex (ACC) during both tasks version with or no conflict will be compared between groups. To better understand the links between the development of the CCA from adolescence to adulthood and conflict detection, activity measurements will be correlated with a part in morphometric measurements taken from the same area (volume Substance Grise - SG; characteristics of cortical sulci) and secondly to cognitive measures (executive functions - inhibitory control). This cross-sectional study focused on two age groups: 11-15 years and 19-25 years. For each age group, the participation of men / boys and women / girls will be balanced up.

Official Title
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Conflict Detection Development During the Reasoning

Conditions
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Healthy Volunteers

Intervention / Treatment
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* Other: MRI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy and educated adolescents aged 11-15 years boy or girl French mother tongue Handedness : right Having been informed by the teen booklet and given its written consent, and whose parents or legal guardian will be ( a) signed the informed consent sheet of the protocol Medical examinations , neurological, neuroradiological norma or All healthy young adults aged 19-25 years at university level or in the workforce man or woman Level ≥ 12 years of study (bachelor level ) Native language: French Handedness : right Signing of the informed consent of the protocol Medical examinations , neurological, neuroradiological norma Exclusion Criteria: Does not meet the targeted age groups Presents against -indications to MRI (severe claustrophobia , foreign bodies cons -indicated ) This chronic intake of alcohol or drugs Cognitive disorders who could testify sudden onset of a stroke ; a history of head injury with loss of consciousness for more than 1 hour , or encephalitis A neurological chronic condition , psychiatric, endocrine , hepatic and infectious Major disease history (diabetes, chronic lung disease, heart disorder, metabolic , hematologic , endocrine or immunological severe, cancer) A medication that may interfere with brain imaging measures ( psychotropics, hypnotics, anxiolytics , neuroleptics, anti -Parkinson , benzodiazepines, anti-inflammatory drugs , antiepileptics, antihistamines , analgesics and muscle relaxants central ) . Manual predominantly left (after the first phone call with the contact person of CYCERON ; see section 9.1) Color Blindness Inability to submit the study for geographical or psychiatric reasons Pregnant and lactating women The following criteria are specific to the adolescent group : Has pervasive developmental disorders and / or acquisitions identified by parents or legal guardian and (or ) the teachers Parents or legal guardian are not affiliated to a system of social security Unaccompanied by parent (s) (s) or legal guardian during the visit to CYCERON center The following criteria are specific to the group of young adults : Non- affiliated to a social security scheme Be protected adult

Ages Eligible for Study
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Minimum Age: 11 Years
Maximum Age: 25 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Adolescents<br>MRI 11-15 years | Other: MRI<br>* Conventional reasoning tasks in both  with and without cognitive conflict and realized during an MRI<br>|
| Experimental: Young adults<br>MRI 19-25 years | Other: MRI<br>* Conventional reasoning tasks in both  with and without cognitive conflict and realized during an MRI<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| brain activity in the anterior cingulate cortex (ACC ) | measured brain activity in the anterior cingulate cortex (ACC ) of healthy volunteers aged 11 to 15 participants , and from 19 to 25 years over two classic version reasoning tasks with and without cognitive conflict and realized on an MRI | Day 1 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the activity recorded in the whole brain | the activity recorded in the whole brain of healthy volunteers aged 11 to 15 participants , and 19 to 25 years in two classic version reasoning tasks with and without cognitive conflict and carried out during the examination MRI | Day 1 | 
| response time | response time recorded version with versus without cognitive conflict , participants in healthy volunteers aged 11-15 and 19-25 years in two classic reasoning tasks performed during an MRI | Day 1 | 
| brain activity measured in the CSF in two classic reasoning tasks | Compare brain activity measured in the CSF in two classic reasoning tasks in both  with and without conflict for each of the healthy volunteers participating groups | Day 1 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Psychology and Cognitive Neuroscience of development, Adolescent and young adult healthy volunteers, Anatomical and functionally Magnetic Resonance Imaging (MRI), Conflict detection, Reasoning