Efficacy of Blue Wavelength in Managing Dry Eye

Study Overview
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Brief Summary
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The study is conducted to evaluate the efficacy of digital blue light blocking filter in improvement of clinical indices of dry eye and ocular symptoms related to dry eye. Introduction: Dry eye disease is a multifactorial disease of the ocular surface caused by loss of tear film homeostasis resulting damage to the ocular surface and neurosensory abnormalities.

Detailed Description
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60 subjects aged 20-35 years with ocular surface disease index score greater than 13 will be taken from the University of Faisalabad. After taking consent, procedure starts from history then Schirmer test 1 will be performed to measure the tear deficient dry eye. Tear break up time will be done to assess the evaporative dry eye. Corneal surface staining will be used to measure corneal erosions. OSDI questionnaire will be used for the evaluation of ocular symptoms related to dry eye. The digital blue light blocking filter will be randomly installed in digital devices of the 80 subjects and rest of 80 will be without filter. After baseline data follow ups will be after 3 weeks and second after 8 weeks of filter use. Schirmer test 1, tear break up time corneal surface staining and OSDI will be performed on both groups (filter users and non-filter users) for the evaluation of dry eye. Data will be analyzed using SPSS version 21. Result of this study will give knowledge that use of digital blue light blocking filters are useful in the management of dry eye disease.

Official Title
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Efficacy of Blue Wavelength in Managing Dry Eye

Conditions
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Dry Eye Disease

Intervention / Treatment
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* Device: Digital blue light blocking filter


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Females with age 20-35years using digital devices androids and laptops Ametropia of up to 1.0 Diopter sphere(DS) and astigmatism of less than 0.5 Emmetropes. Exclusion Criteria: Subjects using topical drugs Smokers Subjects undergoing dry eye treatment History of contact lens wear within the past three months Corneal surface disease other than dry eye Corneal or eyelid infections Corneal surgeries Refractive error of more than 1 DS of SE and astigmatism of greater than0.5DC Age <18 and >3 years Subjects already using blue light blocking filters I phone users Pregnant women Males

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: The digital blue light blocking filter will be randomly installed in digital devices of the 80 subjects and rest of 80 will be without filter.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1 blue light blocking filter group<br>digital blue light blocking filter is installed laptops and mobile phones of 80 individual using digital devices more than 4 hours. asked them to use the filter continuously while using digital devices. | Device: Digital blue light blocking filter<br>* digital blue light blocking filter will be given to 80 dry eye subjects in mobile phones and laptops and 80 individuals will be without filters digital devices users<br>* Other names: F.lux and blue light filter Night mode,Night shift;|
| Experimental: 2 non filter users<br>Effect of time duration of digital screen on the dry eyes is checked. | Device: Digital blue light blocking filter<br>* digital blue light blocking filter will be given to 80 dry eye subjects in mobile phones and laptops and 80 individuals will be without filters digital devices users<br>* Other names: F.lux and blue light filter Night mode,Night shift;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| tear break up time | improvement in evaporative dry eye will be assessed by improvement in tear break up time in seconds after filter use. | 8 weeks | 
| Schirmer test values | improvement in aqueous deficient dry eye by Schirmer test values in mm . | 8 weeks | 
| corneal surface staining | 'corneal surface staining grade scale' assess the improvement corneal surface erosions after filter use | 8 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| ocular surface disease index questionnaire | improvement in ocular surface disease index score.13-22ocular surface disease index score mild dry eye ,23-32 score means moderate dry eye and ocular surface disease index greater than 33 indicate severe dry eye . | 8 weeks |