The Influence of Different At-home Exercise Strategies on 24h Glycemic Control

Study Overview
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Brief Summary
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This study will determine how different at-home exercise strategies influence 24hr glycemic control in women with metabolic dysfunction.

Detailed Description
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Elevations in blood glucose concentration increase risk for cardiometabolic diseases including type 2 diabetes and cardiovascular diseases. Exercise can improve glycemic control, but there is limited research comparing the effectiveness of different exercise strategies in women. The aim of this study is to examine, under free-living conditions, how performing either walking and bodyweight interval exercise after dinner influences glycemic control in women with or at risk for type 2 diabetes. Glycemic control will be measured with continuous glucose monitors.

Official Title
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The Influence of Different At-home Exercise Strategies on 24h Glycemic Control in Women at Risk for With Metabolic Disease

Conditions
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Metabolic Disturbance

Intervention / Treatment
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* Behavioral: Bodyweight interval exercise
* Behavioral: Walking


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Females no cancer history ≥50 years old Have metabolic dysfunction (defined as self-reported diagnosis of pre-diabetes, type 2 diabetes, or at least moderate Canadian diabetes risk (CANRISK) score) Owns a smartphone with Bluetooth capability with Apple or Android operating system deemed safe to exercise as per the CSEP Get Active Questionnaire Enrolled in NCT05454943 Exclusion Criteria: Type 1 diabetes Taking exogenous insulin, sulfonylureas, or GLP-1 receptor agonists Self-reported history of an eating disorder BMI <18.5 kg/m Working night or rotating shifts Eating window <12 hours or consistently eating less than 3 meals/day in the past 3 months Major dietary changes within the past 3 months (i.e. calorie counting, ketogenic diet)

Ages Eligible for Study
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Minimum Age: 50 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Bodyweight interval exercise<br>Performing 15 minutes of bodyweight interval exercise after dinner | Behavioral: Bodyweight interval exercise<br>* Performing 15 minutes of bodyweight interval exercise after dinner at home by following a video<br>|
| Experimental: Walking<br>Performing a 30 minute walk after dinner | Behavioral: Walking<br>* Performing a 30 minute minute walk after dinner at home<br>|
| No Intervention: Non exercise control<br>Performing no exercise after dinner | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 24hr Glucose area under the curve | Glucose area under the curve over 24hr | 24 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 24hr Average glucose concentration | Average glucose concentration over 24 hr | 24 hours | 
| Postprandial dinner glucose response | Measured as the 2hr postprandial glucose incremental area under the curve (iAUC), average glucose and peak glucose | 2 hours | 
| Postprandial breakfast glucose response | Measured as the 2hr postprandial iAUC, average glucose and peak glucose | 2 hours | 
| Postprandial lunch glucose response | Measured as the 2hr postprandial glucose iAUC, average glucose and peak glucose | 2 hours | 
| Nocturnal glucose | Measured as the overnight glucose average and AUC |  6-8 hours | 
| Time in hyperglycemia | Time (minutes and percent per day) above 10mmol/L over 24hr | 24 hours | 
| Time in hypoglycemia | Time (minutes and percent per day) under 3.9mmol/L over 24 hr | 24 hours | 
| Time in range | Time (minutes and percent per day) above 3.9 but under 10mmol/L | 24 hours | 
| Continuous overall net glycemic action (CONGA) | Calculated measure of glycemic variability | 24 hours | 
| Change in glucose during exercise | Post vs. pre glucose concentration around exercise | 15-30 minutes | 
| Mean amplitude glycemic excursion (MAGE) | Calculated measure of glycemic variability | 24 hours | 
| Standard deviation (SD) | Calculated measure of glycemic variability | 24 hours | 
| % coefficient of variation (CV) | Calculated measure of glycemic variability | 24 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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women, glycemic control, exercise