ACToR-study : Angiographic CT of Renal Transplantation Candidate - Study

Study Overview
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Brief Summary
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This study hypothesizes that renal transplantation candidates are diagnosed with significant Coronary Artery Disease (CAD) equal with non-invasive modalities as with invasive modalities. Therefore the investigators are investigating the ability of coronary computed tomographic angiography (cCTA), myocardial perfusion scintigraphy (MPS), acoustic CAD Patch and combination hereof to detect CAD as defined by invasive Coronary angiography (CAG).

Detailed Description
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Chronic kidney disease is a known risk factor for cardiovascular disease and cardiovascular disease is the leading cause of mortality in end-stage renal disease (ESRD) patients. After renal transplantation one-half of all deaths are cardiac, usually in the first 5 years in the presence of a functional graft. Because of this renal transplantation candidates are undergoing cardiac pre-transplant risk stratification. There is no consensus regarding which modality should be use for detection of CAD in this cardiac pre-transplant risk stratification. CAG is known as gold standard but is a invasive procedure with risk of complication. The investigators wish to investigate the ability of detecting CAD as defined by invasive Coronary angiography (CAG) by clinical examination, blood test and non-invasive test (cCTA, MPS and acoustic CAD Patch). The investigators hypothesize that a single modality or combination of these with high sensitivity and specificity could diagnose significant CAD without the need of further invasive procedures. This study will include 150 renal transplantations candidate.

Official Title
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Angiographic CT of Renal Transplantation Candidate - Study

Conditions
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Renal Transplant Candidate for Right Kidney, Renal Transplant Candidate for Left Kidney

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Endstage renal disease Preparing for renal transplantation Indication for CAG Exclusion Criteria: Known allergy to iodinated contrast Women who are pregnant or nursing Severe mental illness

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To investigate the ability of non-invasive tests to detect CAD as defined by invasive angiography in renal transplantation candidates. | Baseline results of coronary computed tomographic angiography (cCTA), myocardial perfusion scintigraphy (MPS), acoustic CAD Patch and combination hereof to detect CAD as defined by invasive Coronary angiography (CAG). | 2013 october | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To investigate the risk of Contrast-Induced Nephropathy (CIN) after cCTA and CAG. | Blood sample of creatinine after contrast exposure. | 2013 october |