Surface Treatment of the Dental Implant on the Osseointegration

Study Overview
=================
Brief Summary
-----------------
Dental implants have become a widely accepted treatment modality for the replacement of missing single or multiple teeth in the recent years. In order to meet patients' needs for shorter treatment times and the necessity of dealing with more challenging clinical situations, implants and implant therapies have undergone continuous improvement to improve the function and longevity of the implants. Recently the constant search for improvements in modern implant have been focused on surface modifications so a new era of surface treatment have been showed up; the chemically modified hydrophilic surfaces.

Official Title
-----------------
The Effect of Surface Treatment of the Dental Implant on the Osseointegration in Mandibular Posterior Missing Teeth

Conditions
-----------------
Dental Implants, Surface Treatment

Intervention / Treatment
-----------------
* Other: Aqua alvim CM, neodent implant (Test)
* Other: Neoporous alvim CM, neodent implant (Control)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Missing mandibular posterior teeth. Good oral hygiene (plaque index less than 10 %) Good compliance to the treatment. Participants are free from local or systemic disease Willingness and ability to commit to follow-up placement. Adequate bone height and width to accommodate implant placement and sufficient keratinzed mucosa. At least 3months after tooth extraction Sufficient interocclusal distance Exclusion criteria Presence of persistent and unresolved infection in the implant site Parafunctional habits. Heavy Smokers. Uncontrolled systemic disease that impedes bone healing

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Hydrophilic sandblasted and acid-etched dental implants<br> | Other: Aqua alvim CM, neodent implant (Test)<br>* Acqua, Hydrophilic sandblasted, and acid-etched dental implants<br>|
| Active Comparator: Conventional hydrophobic sandblasted and acid-etched dental implant<br> | Other: Neoporous alvim CM, neodent implant (Control)<br>* Neoporous, Hydrophilic sandblasted, and acid-etched dental implants<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in implant stability | The implant stability measurement was examined at the time of insertion of the implants (primary stability) and 6 months (secondary stability) for the two groups of patients using the resonance Frequency Analysis (RFA) via the Osstell ISQ system | at baseline and 6 months | 
| Change in bone density | Cone beam Computerized tomography was used to assess bone denisty | at baseline and 6 months | 
| Change in ridge height | Cone beam Computerized tomography was used to assess ridge height | at baseline and 6 months | 
| Biochemical assessment of bone formation | Done by measuring of Runt-related transcription factor 2 (RUNX2) as a bone marker by Enzyme-Linked Immunosorbent Assay | at 3 months |