The Effect of HFNC on Exercise Capacity Compared to VM in COPD Patients Recovering From Acute Evacerbation

Study Overview
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Brief Summary
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Early PR is thought to be effective in COPD patients recovering from acute exacerbation, while the effect of HFNC during exercise training in these patients remains unclear. The study may provide evidence of early PR in COPD patients recovering from acute exacerbation.

Detailed Description
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We hypothesize that HFNC may increases exercise time in COPD patients recovering from acute exacerbation compare to VM. A randomized, cross-over clinical trial in which either HFNC or VM may be used as an adjunct in 10-MST in random order, respectively, will be performed to compare the endurance time. The physiological effect of HFNC and VM during exercise will also be measured to explore the mechanism.

Official Title
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The Effect of High Flow Nasal Cannula on Exercise Capacity Compared to Venturi Mask in COPD Patients Recovering From Acute Evacerbation

Conditions
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COPD

Intervention / Treatment
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* Device: high flow nasal cannula
* Device: Venturi mask


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: hospitalized AECOPD patients be ambulatory by 48h after admission for AECOPD requires oxygen by screening exercise test Exclusion Criteria: active coronary ischemia respiratory diseases other than COPD unstable vital signs unstable psychological status

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: HFNC group<br>Set FiO2 28% Titrate the flow of HFNC at the highest tolerated value up to 60 L/min | Device: high flow nasal cannula<br>* HFNC provides humidified, heated, oxygen-enriched air at constant concentration with a flow up to 60L/min through a nasal cannula. It washouts the anatomical dead space and decreases the work of breathing.<br>|
| Active Comparator: VM group<br>- Keep FiO2 constant with VM and HFNC during the two trial | Device: Venturi mask<br>* VM is commonly used by COPD patients during exercise training.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Endurance time | Endurance time for 10 minute steping test | 10 minute | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Respiratory pattern | Respiratory pattern is calculated by the flow and time | 10 minute | 
| Work of breathing | Work of breathing is calculated by the transdiaphragmatic pressure | 10 minute | 
| Neural respiratory drive | Neural respiratory drive is calculated by diaphragm electromyogram | 10 minute | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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HFNC, PR