Fenretinide in Treating Patients With Recurrent or Metastatic Head and Neck Cancer

Study Overview
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Brief Summary
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RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of fenretinide in treating patients who have recurrent or metastatic head and neck cancer.

Detailed Description
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OBJECTIVES: Determine the response rate, time to progression, median survival, and percent of 1-year survival in patients with recurrent or metastatic squamous cell carcinoma of the head and neck treated with fenretinide. Determine the pharmacokinetics and safety of this drug in these patients. OUTLINE: Patients receive oral fenretinide every 12 hours on days 1-7. Treatment repeats every 3 weeks for at least 3 courses in the absence of disease progression or unacceptable toxicity. Patients who achieve complete response continue treatment for 1 year. PROJECTED ACCRUAL: A total of 16-35 patients will be accrued for this study.

Official Title
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A Phase II Study of Fenretinide in Recurrent and Metastatic Squamous Cell Carcinoma of the Head and Neck

Conditions
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Head and Neck Cancer

Intervention / Treatment
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* Drug: Fenretinide


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Biopsy-proven recurrent squamous cell carcinoma of the head and neck Stage 4 disease, either at initial presentation or at recurrence. Patients with metastatic disease at initial presentation must have received at least one prior course of cytotoxic chemotherapy. Patients who present with metastatic disease should have received no more than one prior regimen of chemotherapy or biologic therapy to be eligible. Patients who initially received adjuvant or induction chemotherapy and then recurred may have received one additional cycle of chemotherapy or biologic therapy at the time of recurrence. Patients may have received any number of cycles of a particular regimen of chemotherapy. Patients must have a life expectancy of at least 3 months Biopsy of the recurrent lesion(s) is encouraged but not mandatory for enrollment. Performance status grade 0-2. Serum creatinine <= 1.5 mg/dL. Serum transaminases and bilirubin <= 1.5 time normal. Age >= 18 years. White blood cell count >= 3,000; platelets >= 100,000; hemoglobin >= 9mg/dl. Signed informed consent. Women of childbearing potential must agree to utilize two methods of effective birth control, one barrier, one hormonal, or should abstain from sexual intercourse that could result in pregnancy. Contraceptive measures should be continued for at least one month after fenretinide administration has been discontinued. It is recommended that male patients with female partners of childbearing potential use barrier contraception while on fenretinide. Exclusion Criteria: Pregnant women (women of childbearing potential must have a negative pregnancy test within 24 hours prior to enrollment in the study); women who are currently breast-feeding. Grade 2 or greater peripheral neuropathy Concurrent treatment with cytotoxic chemotherapy or radiation Serious infection or other intercurrent illness requiring immediate therapy. Inability to take oral medications, or other medical or social factors interfering with compliance. Patients on high dose synthetic or natural Vitamin A derivatives (>= 10,000 per day). Patients should not take any anti-oxidants such as Vitamin C or E.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Fenretinide<br> | Drug: Fenretinide<br>* 1800 mg/m2 per day for seven consecutive days, in two divided doses of 900 mg/m2 12 hours apart, repeated every 3 weeks.<br>* Other names: 4-HPR;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To determine the response rate, time to progression, median survival, and percent one-year survival | To determine the response rate, time to progression, median survival, and percent one-year survival. | one-year survival | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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untreated metastatic squamous neck cancer with occult primary, recurrent metastatic squamous neck cancer with occult primary, metastatic squamous neck cancer with occult primary squamous cell carcinoma, stage IV squamous cell carcinoma of the lip and oral cavity, recurrent squamous cell carcinoma of the lip and oral cavity, stage IV squamous cell carcinoma of the oropharynx, recurrent squamous cell carcinoma of the oropharynx, recurrent squamous cell carcinoma of the nasopharynx, stage IV squamous cell carcinoma of the hypopharynx, recurrent squamous cell carcinoma of the hypopharynx, stage IV squamous cell carcinoma of the larynx, recurrent squamous cell carcinoma of the larynx, stage IV squamous cell carcinoma of the paranasal sinus and nasal cavity, recurrent squamous cell carcinoma of the paranasal sinus and nasal cavity, stage IV squamous cell carcinoma of the nasopharynx