Computerized Training for Individuals Diagnosed With Obsessive-Compulsive and Related Disorders

Study Overview
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Brief Summary
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Obsessive-Compulsive Disorder (OCD) is a chronic and disabling disorder that costs the economy over $2 billion annually and represents a significant public health problem. This study aims to build on our understanding of aberrant emotional processing in OCD. The proposed project tests whether a computerized training aimed to alter emotional processes, can relieve repetitive thoughts and behaviors.

Official Title
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Emotional Reactivity Training for Obsessive-Compulsive and Related Disorders

Conditions
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Obsessive Compulsive Disorder

Intervention / Treatment
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* Behavioral: Computerized Training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age 18 years old and older primary diagnosis of OCD sufficient severity of OCD symptoms Stable on psychotropic or other medication capacity to provide informed consent Exclusion criteria: psychiatric or medical conditions that make participation unsafe concurrent use of any medications that might increase the risk of participation concurrent Cognitive-Behavioral therapy for OCD

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Active Training<br>OCD participants will receive active emotional reactivity training (14 sessions) via computer. | Behavioral: Computerized Training<br>* OCD participants will receive 14 sessions of training via computer within 3 weeks.<br>|
| Sham Comparator: Passive Training<br>OCD participants will receive passive computerized training (14 sessions) via computer. | Behavioral: Computerized Training<br>* OCD participants will receive 14 sessions of training via computer within 3 weeks.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Yale-Brown Obsessive Compulsive Scale (for participants diagnosed with OCD) | Improvement in OCD severity is measured by the YBOCS (Yale Brown Obsessive-Compulsive Scale), a gold standard measure of obsessions and compulsions. For the YBOCS the minimum units are 0 and Maximum units on the total scale are 40. The higher the number on the YBOCS, the more severe the symptoms. Response is defined as at least a 35% reduction on the YBOCS. | up to 2 months | 
| Savings Inventory Revised Scale (for participants diagnosed with hoarding disorder) | The SI-R is a 23-item questionnaire with 3 factor-analytically defined sub-scales for difficulty discarding, excessive clutter, and compulsive acquisition. | up to 2 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Obsessive-Compulsive Disorder, OCD, Obsessive Personality Disorder, Compulsive Behavior, Personality Disorders, Mental Disorders, Anxiety Disorders, Impulsive Behavior, Cognition, Emotion, Emotional Regulation