Prognostic Value of P30 After Cardiac Arrest

Study Overview
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Brief Summary
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This study aims to examine whether P30 wave of somatosensory evoked potentials (SEP) is related with outcome after cardiac arrest. The study design is a prospective, multicenter-observational study. Patients survived after out-of-hospital cardiac arrest undergoing hypothermic-targeted temperature management will participate in the study. Relationship of P30 wave of SEP with the neurologic outcome on hospital discharge will be evaluated.

Detailed Description
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The absence of N20 of the somatosensory evoked potentials (SEP) is recommended as a valuable predictor of poor neurologic outcome in post-cardiac arrest patients. However, interpretation of N20 is affected by the background noise levels. Reliable analysis of N20 is limited with high noise levels and artifacts. Moreover, presence of N20 does not guarantee good neurologic outcome. P30 is a positive deflection of N20 occurring on 25-35 msec. According to our pilot study, N20 without following P30 is related with poor outcome, while N20 followed by P30 is highly related with good outcome. P30 is evident even when the N20 is ambiguous in patients with good outcome. We hypothesized that the negative-positive deflection of N20-P30 components is more valuable predictor than the N20 alone. In this observational study, we will identify whether presence of P30 checked on 24 and 72 hours after cardiac arrest predicts neurologic outcome more accurately than the presence of N20 alone.

Official Title
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Characteristics of the Somatosensory Evoked Potentials Indicating Poor Neurologic Outcome After Cardiac Arrest

Conditions
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Out-Of-Hospital Cardiac Arrest

Intervention / Treatment
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* Device: Somatosensory evoked potential


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Comatose survivors after out-of-hospital cardiac arrest Exclusion Criteria: Not treated by hypothermic-targeted temperature management

Ages Eligible for Study
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Minimum Age: 19 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: Somatosensory evoked potential|Somatosensory evoked potential on 24, 72 hours after cardiac arrest.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Association of abscence of P30 with poor outcome without under the influence of hypothermia and sedation | SEP under the normothermic-TTM without sedation | 72 hours after ROSC | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Association of abscence of P30 with poor outcome under the influence of hypothermia and sedation | SEP under the hypothermic-TTM with sedation | 24 hours after ROSC | 
| Association of N20 with high amplitude with poor outcome without under the influence of hypothermia and sedation | SEP under the normothermic-TTM without sedation | 72 hours after ROSC | 
| Association of N20 with high amplitude with poor outcome under the influence of hypothermia and sedation | SEP under the hypothermic-TTM with sedation | 24 hours after ROSC | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Heart arrest, hypothermia, SEP, prognosis