Follow up for Patients With Thyroid Cancer Planed for Radioiodine Scan or Treatment

Study Overview
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Brief Summary
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The prevalence of thyroid cancer has increased in recent decades. Patients with thyroid cancer need to choose between Thyrogen® injection and Eltroxin® withdrawal before radioiodine therapy or scan. This is a prospective, observational study, aiming to observe the difference of metabolic profiles between patients choose Thyrogen® injection and Eltroxin® withdrawal.

Detailed Description
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Objective： To observe the difference between Thyogen® injection or Eltroxin® withdrawal on metabolic profile. Background and method:： The prevalence of thyroid cancer has increased in recent decades. Patients with thyroid cancer need to choose between Thyrogen® injection and Eltroxin® withdrawal before radioiodine therapy or scan. This is a prospective, observational study, aiming to observe the difference of metabolic profiles between patients choose Thyrogen® injection and Eltroxin® withdrawal. Inclusion ： Patient number: 500人 Inclusion criteria : Patients with diagnosis of thyroid cancer。 Patients who need radioiodine therapy or scan。 Exclusion criteria: Patients cannot cooperate with blood test.。 Patients cannot cooperate with radioiodine therapy。 Study design： Prospective, observational study。 Method： We will collect 20cc blood and 20 cc urine before and after radioiodine therapy during each visit (total 3 visits) and check lipid profiles, glucose profiles and inflammation markers. We will compare the difference between results of patients undergoing Thyrogen® injection and Eltroxin® withdrawal.

Official Title
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Follow up for Patients With Thyroid Cancer Planed for Radioiodine Scan or Treatment

Conditions
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Thyroid Cancer

Intervention / Treatment
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* Radiation: radioiodine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with diagnosis of thyroid cancer。 Patients who need radioiodine therapy or scan。 Exclusion Criteria: Patients cannot cooperate with blood test.。 Patients cannot cooperate with radioiodine therapy。

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Radiation: radioiodine|Patients with thyroid cancer need to choose between Thyrogen® injection and Eltroxin® withdrawal before radioiodine therapy or scan.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Zung's Self-reported depression scale | Depression symtpoms | 1 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Brain-derived neurotrophic factor | BDNF | 1 month | 
| orexin | An associated factor for depression | 1 month | 
| Body composition | Fat component percentage to lean mass percentage ratio | 1 months | 
| VCAM-1 | adhesion molecules | 1 months | 
| CRP | inflammation marker | 1 months | 
| Metabolic syndrome | The number of conponents for metabolic syndrome | 1 months |