The Correlation Between Degeneration of Paraspinal Muscle and Outcome of Patients With Lumbar Spinal Stenosis

Study Overview
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Brief Summary
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The photographical and functional parameters of paravertebral muscle in patients with lumbar spinal stenosis will be measured to investigate the correlation between paravertebral muscle degeneration and symptoms and prognosis of patients.By measuring the parameters of paravertebral muscle with normal people, the differences between the patients and normal people will be compared to establish an appropriate paravertebral muscle evaluation method.

Detailed Description
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It is a prospective observational study. This study will recruit 200 patients with lumbar spinal stenosis who will undertake posterior lumbar decompression and fusion surgery in our hospital.They all take preoperative lumbar mri examination and waist and back muscle strength test as well as recording their preoperative visual analogue scale,oswestry disability index, lumbar stiffness disability index score.All patients will receive a follow-up lasting for 1 year,and we will record patients outcomes,such as visual analogue scale,oswestry disability index and lumbar stiffness disability index score at each follow-up time. At the same time,we will recruit 100 healthy subjects without lumbar diseases or chronic lumbar pain. The difference of their age with patients was less than 5 years. Meanwhile, lumbar dorsal muscle strength test and lumbar mri examination were conducted, and visual analogue scale as well as oswestry disability index and lumbar stiffness disability index score was recorded in healthy subjects.

Official Title
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The Correlation Between Degeneration of Paraspinal Muscle and Outcome of Patients With Lumbar Spinal Stenosis

Conditions
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Lumbar Spinal Stenosis, Paraspinal Muscle

Intervention / Treatment
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* Other: observation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients with lumbar spinal stenosis age>45 years old without other spinal disease without history of former spinal surgery Exclusion Criteria: With neuromuscular diseases With hip joint or knee joint disease Acute or severe chronic back pain of spinal stenosis that could interfere with the evaluation of endurance Other serious diseases impacting the evaluation of endurance

Ages Eligible for Study
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Minimum Age: 45 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| patients<br>(1) age ≥ 45 years, (2) diagnosed LSS through a combination of clinical history, physical examination and radiological changes showing spinal canal stenosis on magnetic resonance imaging | Other: observation<br>* observation the difference between two groups<br>|
| healthy people<br>(1) age ≥ 45 years; (2) without chronic low back pain (LBP) | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| cross-sectional area of paraspinal muscles | the cross-sectional area of paraspinal muscles reflects the quantity of paraspinal muscles. Higher cross-sectional area of paraspinal muscles means larger paraspinal muscle. | Baseline | 
| functional cross-sectional area of paraspinal muscles | functional cross-sectional area of paraspinal muscles reflects the quality of paraspinal muscles. It means the lean paraspinal muscle. | Baseline | 
| Performance time of paraspinal muscle endurance test | Participants were asked to lie prone on a plinth and lift their sternum from the plinth, raising their upper body.While maintaining this position, participants were asked to keep their arms in line with the body axis and not in contact with the plinth. Task failure was determined by a drop in the angle of trunk of greater than 10°at any point. The time was recorded until task failure or until the maximum contraction duration was reached (300 s). | Baseine | 
| lumbar stiffness disability index | The lumbar stiffness disability index ranges from 0 to 100. Higher scores mean a worse outcome | the follow-up time of 3 months | 
| lumbar stiffness disability index | The lumbar stiffness disability index ranges from 0 to 100. Higher scores mean a worse outcome. | the follow-up time of 6 months | 
| lumbar stiffness disability index | The lumbar stiffness disability index ranges from 0 to 100. Higher scores mean a worse outcome. | the follow-up time of 12 months | 
| lumbar stiffness disability index | The lumbar stiffness disability index ranges from 0 to 100. Higher scores mean a worse outcome. | Baseline | 
| The Oswestry Disability Index | The Oswestry Disability Index ranges from 0 to 100.Higher scores mean a worse outcome. | Baseline | 
| The Oswestry Disability Index | The Oswestry Disability Index ranges from 0 to 100.Higher scores mean a worse outcome. | the follow-up time of 3 months | 
| The Oswestry Disability Index | The Oswestry Disability Index ranges from 0 to 100.Higher scores mean a worse outcome. | the follow-up time of 6 months | 
| The Oswestry Disability Index | The Oswestry Disability Index ranges from 0 to 100.Higher scores mean a worse outcome. | the follow-up time of 12 months | 
| Visual Analog Score | Visual Analog Score is used to evaluate pain,ranging from 0 to 10.Higher scores mean a worse outcome. | Baseline | 
| Visual Analog Score | Visual Analog Score is used to evaluate pain,ranging from 0 to 10.Higher scores mean a worse outcome. | the follow-up time of 3 months | 
| Visual Analog Score | Visual Analog Score is used to evaluate pain,ranging from 0 to 10.Higher scores mean a worse outcome. | the follow-up time of 6 months | 
| Visual Analog Score | Visual Analog Score is used to evaluate pain,ranging from 0 to 10.Higher scores mean a worse outcome. | the follow-up time of 12 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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degeneration of paraspinal muscle, lumbar spinal stenosis