Imatinib Mesylate in Combination With Docetaxel for Advanced, Platinum-Refractory Ovarian Cancer

Study Overview
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Brief Summary
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Imatinib mesylate is an inhibitor of the receptor tyrosine kinases for platelet-derived growth factor (PDGF) and stem cell factor (SCF), c-Kit, and inhibits PDGF- and SCF-mediated cellular events. Docetaxel promotes cell growth arrest by inhibiting the deassembly of tubulin and by promoting at the same time microtubule assembly. Docetaxel has single agent activity in ovarian cancer with response rates of 30-40% in the platinum refractory setting. The combination of imatinib mesylate and docetaxel has potential synergistic effects, based on previous reports showing synergy in-vitro and in-vivo between PDGFR inhibitors or PI3K inhibitors and taxane chemotherapy. This trial will investigate the efficacy the combination of imatinib mesylate and docetaxel in treating patients with advanced, platinum-refractory ovarian cancer and primary peritoneal carcinomatosis.

Detailed Description
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OUTLINE: This is a multi-center study. Submit tumor and serum samples for central review Imatinib 600 mg (orally qd); Docetaxel 30mg/m2 (4 of 6 weeks);1 cycle = 6 weeks Evaluate every other cycle Each cycle will begin only when the granulocyte count is > 1,500/mm3 and the platelet count is > 100,000/mm3 and any other treatment-related toxicities are < grade 1. If the toxicity is not resolved to grade 0 or 1 after three weeks, the patient will be withdrawn from the study. For days 8, 15, and 22 patients must have an absolute neutrophil count > 1,000/mm3 or greater and platelet count > 75,000/mm3. Imatinib mesylate can be administered if platelets >20,000 and ANC >500. ECOG performance status 0 or 1 Hematopoietic:· ANC > 1,500/mm3· Platelets > 100,000 mm3· Hgb > 8g/dl Hepatic:· Albumin>3gm/dL· Total bilirubin < ULN· Maximum Alk Phos: >2.5x but < 5x ULN Renal:· Creatinine < 1.5 x ULN·(by Cockroft and Gault) Cardiovascular:· No grade III/IV cardiac problems as defined by the New York Heart Association Criteria. (i.e., congestive heart failure, myocardial infarction within 6 months prior to beginning protocol therapy) Pulmonary:· Not specified

Official Title
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Imatinib Mesylate (Gleevec®, STI571) in Combination With Docetaxel (Taxotere) for the Treatment of Advanced, Platinum-Refractory Ovarian Cancer and Primary Peritoneal Carcinomatosis: Hoosier Oncology Group GYN03-62

Conditions
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Ovarian Cancer

Intervention / Treatment
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* Drug: Imatinib Mesylate
* Drug: Docetaxel


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Histologically documented diagnosis of ovarian cancer, primary peritoneal carcinomatosis or fallopian tube cancer· Immunohistochemical documentation of c-Kit or PDGFR expression by tumor At least one measurable site of disease as defined by RECIST or evidence of disease progression by CA125 measurement Platinum-refractory or platinum-resistant Exclusion Criteria: No prior exposure to imatinib (Gleevec®) as single agent or in combination No chemotherapy within 28 days (42 days for nitrosourea or mitomycin-C) prior to being registered to protocol therapy. No prior radiotherapy to ³ 25 % of the bone marrow No known brain metastases. Negative pregnancy test No current breastfeeding No investigational agents within 28 days prior to protocol therapy No prior malignancy in the past 5 years unless the other primary malignancy is not currently clinically significant, nor requiring active intervention, or if other primary malignancy is a basal cell skin cancer or a cervical carcinoma in situ No severe and/or uncontrolled medical disease (i.e., uncontrolled diabetes, chronic renal disease, or active uncontrolled infection) No known diagnosis of human immunodeficiency virus (HIV) infection. No major surgery within 28 days prior to being registered to protocol therapy. No refractory ascites requiring drainage more frequently than once a month No presence of clinically significant small bowel obstruction No prior exposure to docetaxel (exposure to paclitaxel is allowed) No parenteral nutrition within 28 days prior to being registered to protocol therapy. No concomitant treatment with potent CYP 3A4 inhibitors (i.e., ketoconazole) is permitted during therapy on this protocol. No therapeutic anticoagulation with warfarin while on study (use of low molecular weight heparin is allowed, if necessary). No peripheral neuropathy > grade 1 No history of severe hypersensitivity reaction to docetaxel or other drugs formulated with polysorbate 80. No serious concomitant systemic disorders incompatible with the study No prior malignancies with the exception of curatively treated basal or squamous carcinoma of the skin, carcinoma in-situ of the cervix, or any other cancer for which the patient has been disease-free for < 5 years.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Investigational Treatment<br>Imatinib Mesylate + Docetaxel | Drug: Imatinib Mesylate<br>* Imatinib mesylate 600 mg po qd<br>Drug: Docetaxel<br>* Docetaxel 30 mg/m2 (4 of 6 weeks); 1 cycle = 6 weeks<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| · To determine response rate (CR, PR and SD) of patients with advanced, platinum-refractory ovarian cancer, whose tumors over-express PDGFR or c-kit receiving imatinib mesylate in combination with docetaxel. |  | 24 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| · To assess the safety and tolerability of imatinib mesylate in combination with docetaxel in patients with advanced, platinum-refractory ovarian cancer, whose tumors over-express PDGFR or c-kit. |  | 24 months | 
| · To determine progression free survival and overall survival in patients with advanced, platinum-refractory ovarian cancer, whose tumors over-express PDGFR or c-kit, receiving imatinib mesylate in combination with docetaxel. |  | 24 months | 
| · To determine whether basal level of Akt expression or Akt activation (phospho-Akt) in ovarian tumors impacts response to treatment with imatinib and docetaxel. |  | 24 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Ovarian Cancer