Incidence Rate of Heart Failure After Acute Myocardial Infarction With Optimal Treatment

Study Overview
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Brief Summary
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The main purpose of this study is to build a multi-center, prospective and regionally representative acute myocardial infarction(AMI) cohort，and build a study platform for heart failure caused by AMI; To explore the 1 year incidence rate of heart failure after AMI given the optimized treatment and the treatment model affecting the incidence rate of heart failure, and finally to reduce the incidence rate of heart failure by 5%.

Detailed Description
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the study aim to enroll 12000 acute myocardial infartion (AMI) patients, including ST-segment elevation myocardial infarction (STEMI) and non ST-segment elevation myocardial infarction (NSETMI), Patients were divided into two groups(optimized group and un-optimized group) according to treatment models they accepted in 20 reginally representative hosptials of China. whether optimizaed or not is judged by 4 four aspects,including emergency treatment procedure, pre-infusion medication, reperfusion strategy selection, and early rehabilitation after reperfusion.Patients were followed at 1 month, 6 months and 12 months. The physical condition and clinical events(heart failure, death, re-infarction, revascularization, apoplexy, malignant arrhythmias, bleeding events, other adverse events)were collected at follow up.

Official Title
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One Year Incidence Rate of Heart Failure After Acute Myocardial Infarction With Optimal Treatment-A Prospective,Multicenter,Cohort Study

Conditions
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Acute Myocardial Infarction, Heart Failure

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age≥18 years diagnosed acute myocardial infarction signed the informed consent form Exclusion Criteria: AMI is caused by surgery, trauma, gastrointestinal bleeding or complications of PCI; AMI occurred in patients who have been hospitalized for other reasons; patients with previous history of chronic heart failure; researchers judging that patient's compliance was poor and could not complete the study according to the requirements. life expectancy is less than 12 months; heart transplant patients; patients with tumors;

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| optimized group<br>the patients in this group have been given the suggestive treatment from guideline. | |
| un-optimized group<br>the patients in this group have not been given the suggestive treatment from guideline. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| incidence rate of heart failure | incidence rate of heart failure of acute myocardial infarction at 12th month | 12th month after diacharge | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| MACCE rate | the major adverse cardiac celebral events including death,reinfarction, | 12th month after diacharge | 
| bleeding rate | the incidence rate of bleeding | 12th month after diacharge | 
| severe adverse drug reactions | severe adverse drug reactions at 12th month | 12th month after diacharge | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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acute myocardial infarction, heart failure, optimized treatment