Interest of Pulse Wave Velocity Measurement as a Predictor of Severity of Aortic Stenosis

Study Overview
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Brief Summary
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Aortic valve pathology is the third most common cardiovascular disease after coronary artery disease and hypertension, which is responsible for severe morbidity and mortality in elderly patients and requires surgical treatment in its most severe form of progression. The purpose of this study is to find a link between arterial stiffness and degenerative aortic stenosis. If this link is established, arterial stiffness may become a medical therapeutic target in order to delay the evolution of the disease.

Official Title
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Interest of Pulse Wave Velocity Measurement as a Predictor of Severity of Aortic Stenosis

Conditions
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Pulse Wave, Aortic Stenosis

Intervention / Treatment
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* Other: Study the relationship between the arterial rigidity of large vessels and the presence and severity of degenerative aortic constriction
* Other: Control group without heart disease


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients over 18 years of age, without legal protection (guardianship or curatorship), Stable hemodynamic status. Affiliation to a social security scheme Exclusion Criteria: Hemodynamically unstable patients: Systolic PA <10 cmHg, rapid peripheral pulse and spinning, mottling, obnubilation, oliguria, sweating, coma History of significant valvulopathy other than an aortic stenosis, Pregnancy. Patient under tutelage or curatelle or deprived of public right.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Control group of 150 heart disease-free individuals<br> | Other: Control group without heart disease<br>* Control group without heart disease<br>|
| Other: Patients with aortic sclerosis<br> | Other: Study the relationship between the arterial rigidity of large vessels and the presence and severity of degenerative aortic constriction<br>* Study the relationship between the arterial rigidity of large vessels and the presence and severity of degenerative aortic constriction<br>|
| Other: Patients with moderate aortic stenting (RA)<br> | Other: Study the relationship between the arterial rigidity of large vessels and the presence and severity of degenerative aortic constriction<br>* Study the relationship between the arterial rigidity of large vessels and the presence and severity of degenerative aortic constriction<br>|
| Other: Patients with Serious Aortic Retention<br> | Other: Study the relationship between the arterial rigidity of large vessels and the presence and severity of degenerative aortic constriction<br>* Study the relationship between the arterial rigidity of large vessels and the presence and severity of degenerative aortic constriction<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Analysis of echocardiographic measurements of possible differences between average VOP and Sao i in terms of RA severities | Analysis of echocardiographic measurements of possible differences between average VOP and Sao i in terms of RA severities | 10 years |