Association Between Metabolic Syndrome and Serum Nerve Growth Factor Levels in Women With Overactive Bladder

Study Overview
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Brief Summary
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Nerve growth factor (NGF-R) receptors are between the detrusor muscle fibers and can cause afferent signals. Metabolic syndrome and obesity have been advocated to be risk factors for the development of overactive bladder.

Detailed Description
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Overactive bladder is a clinical syndrome characterized urgency, frequency and nocturia. Infection or other obvious causes must be excluded. The overactive bladder is loss of inhibition of the detrusor muscle during the filling or emptying of the bladder. Specific receptors and neurotransmitters have role in development of overactive bladder. These includes adrenergic, cholinergic, non-adrenergic, non-cholinergic receptors and interstitial cells. Nerve growth factor (NGF-R) receptors are between the detrusor muscle fibers and can cause afferent signals. Metabolic syndrome and obesity have been advocated to be risk factors for the development of overactive bladder. The investigators believe that our findings will shed light on treatment.

Official Title
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Association Between Metabolic Syndrome and Serum Nerve Growth Factor Levels in Women With Overactive Bladder

Conditions
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Overactive Bladder

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: women with urgency, nocturia and frequency Abdominal obesity, defined as a waist circumference in men ≥88 cm Serum triglycerides ≥150 mg/dL (1.7 mmol/L) or drug treatment for elevated triglycerides Serum HDL cholesterol <40 mg/dL (1 mmol/L) in men and <50 mg/dL (1.3 mmol/L) in women or drug treatment for low HDL-C Blood pressure ≥130/85 mmHg or drug treatment for elevated blood pressure Fasting plasma glucose (FPG) ≥100 mg/dL (5.6 mmol/L) or drug treatment for elevated blood glucose Exclusion Criteria: Chronic obstructive pulmonary disease allergy Psychiatric disorders Urinary tract infection Neurological diseases Metabolic diseases Pure stress or mixed urinary incontinence History of pelvic surgery Diabetes mellitus

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| women with metabolic syndrome and overactive bladder<br>women with urinary urgency+frequency+nocturia and current ATP III criteria define the metabolic syndrome as the presence of any three of the following five traits: Abdominal obesity, defined as a waist circumference in men ≥88 cm Serum triglycerides ≥150 mg/dL (1.7 mmol/L) or drug treatment for elevated triglycerides Serum HDL cholesterol <40 mg/dL (1 mmol/L) in men and <50 mg/dL (1.3 mmol/L) in women or drug treatment for low HDL-C Blood pressure ≥130/85 mmHg or drug treatment for elevated blood pressure Fasting plasma glucose (FPG) ≥100 mg/dL (5.6 mmol/L) or drug treatment for elevated blood glucose | |
| women with overactive bladder<br>women with urinary urgency+frequency+nocturia | |
| healthy control group<br>women not overactive bladder and metabolic syndrome | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| nerve growth factor levels | association between nerve growth factor levels and overactive bladder | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| urge incontinence | number of urge incontinence | 3 months | 
| overactive bladder symptoms | number of nocturia,urgency,frequency | 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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urinary bladder, nerve growth factor, overactive bladder