Effect of Protein Blend Supplementation During Exercise Training on Muscle Growth and Strength

Study Overview
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Brief Summary
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This study will investigate the effects of a soy/dairy protein blend on muscle growth and strength. In sports nutrition and in aging it is important to have healthy muscles. This can be achieved with exercise and nutrition. Consumption of protein following resistance exercise can promote healthy muscle growth and help improve strength. Young healthy men will be studied during a 12 week resistance exercise training program and be given protein supplements every day during the study. The hypothesis is that a blend of soy, whey and casein will induce a greater muscle gain and strength increase than the control.

Official Title
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A Randomized, Controlled Double Blind Longitudinal Study: Effect of Protein Blend Supplementation During Exercise Training on Muscle Growth and Strength

Conditions
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Muscle

Intervention / Treatment
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* Dietary Supplement: Blend
* Dietary Supplement: Whey
* Dietary Supplement: Placebo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Stable body weight, healthy, males aged 18-35 Exclusion Criteria: Exercise training (>2 weekly sessions of moderate to high intensity aerobic or resistance exercise) Resistance Training (>2 weekly sessions of moderate to high intensity) within the past six months Any orthopedic injury that prohibits participation in the exercise training Significant heart, liver, kidney, blood, or respiratory disease Peripheral vascular disease Diabetes mellitus or other untreated endocrine disease Active cancer (all groups) and history of cancer Acute infectious disease or history of chronic infections (e.g. TB, hepatitis, HIV, herpes) Recent (within 6 months) treatment with anabolic steroids, or corticosteroids. Alcohol or drug abuse Tobacco use (smoking or chewing) BMI range will be (20-29.9 kg/m2) to exclude for Malnutrition (hypoalbuminemia, and/or hypotransferrinemia) and Obesity Low hemoglobin levels (below normal values) Food allergies (including milk and soy) Individuals on a Vegetarian Diet Females Average protein intake < 0.6 or >1.8 g/kg per day Taking dietary supplements such as green tea, creatine, ribose, whey or soy protein, etc. within the past 6 months Currently on a high-soy diet or high dairy diet (consuming >2 servings of soy per day or >6 servings of dairy)

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Placebo<br>Placebo dry blended beverage (carbohydrate) | Dietary Supplement: Placebo<br>* 22 grams of carbohydrate/day<br>|
| Experimental: Blend<br>A dry blended beverage containing a protein blend of soy, whey and casein | Dietary Supplement: Blend<br>* 22 grams of protein/day<br>|
| Active Comparator: Whey<br>A dry blended beverage containing Whey protein | Dietary Supplement: Whey<br>* 22 grams of protein/day<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Muscle Mass | Muscle Mass will be determined by DEXA | Baseline, 6 weeks, 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Muscle Strength | Knee Extensor | Baseline, 6 weeks, 12 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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soy, whey, casein, muscle, strength, protein