Developing Mouse Models of Breast Cancer Using Tissue Samples From Women With Breast Cancer

Study Overview
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Brief Summary
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RATIONALE: Changing the genes in laboratory mice to create a living model of human breast cancer may help doctors learn more about breast cancer. PURPOSE: This research study is developing mouse models of breast cancer using tissue samples that were previously collected from women with breast cancer.

Detailed Description
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OBJECTIVES: To develop new in vivo models of human breast cancer. To correlate response in this model to actual treatment outcome in patients, if the in vivo model is proven feasible. OUTLINE: Previously collected breast tumor fragments are implanted into the renal capsule site of SCID mouse hosts (mouse with severe combined immune deficiency) to establish metastatic spread patterns, and both histologic and molecular tumor characteristics. Patients' medical charts are reviewed to obtain relevant information, including general demographics, smoking and alcohol use, as well as outcome data such as survival and response to treatment.

Official Title
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Developing In-Vivo Models of Human Breast Cancer

Conditions
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Breast Cancer

Intervention / Treatment
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* Other: laboratory biomarker analysis
* Other: medical chart review


Participation Criteria
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Eligibility Criteria
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DISEASE CHARACTERISTICS: Diagnosis of breast cancer Any stage of disease Primary or metastatic disease Human breast tumor tissues available after the diagnoses have been made Enrolled on the ongoing Breast Tissue Repository trial VU-VICC-BRE-03103 Have consented to the use of their tissues for research purpose Hormone receptor status not specified PATIENT CHARACTERISTICS: Menopausal status not specified PRIOR CONCURRENT THERAPY: Not specified

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| breast cancer patients<br> | Other: laboratory biomarker analysis<br>* Tissue samples will either be collected at the time of medically indicated surgical procedures or through research core biopsies. A sample of urine will also be obtained. Blood will be collected via venipuncture and lymphocytes (mononuclear cells) separated and processed as a source of normal DNA and normal cells.<br>Other: medical chart review<br>* patient chart review will occur in conjunction with patient data collection for final analyses.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Development of new in vivo models of human breast cancer |  | 1 year | 
| Correlation of response in this model to actual treatment outcome in patients, if the in vivo model proven feasible |  | 5 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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breast cancer