Laser Assisted Nonsurgical Periodontal Treatment

Study Overview
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Brief Summary
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Periodontitis is a chronic inflammatory disease caused by mixed infections with the subgingival microbiota being organized as a biofilm that, if untreated, may result in breakdown of the periodontal tissues in susceptible individuals. Evidence from intervention studies shows that mechanical root debridement significantly improves periodontal health by halting the progression of periodontal tissue breakdown. In order to improve effectiveness and efficacy of the removal of the subgingival biofilm, Er:YAG laser therapy has recently been recommended as an alternative to conventional scaling procedures.

Official Title
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Clinical and Microbiologic Effects of Nonsurgical Periodontal Treatment Combined With an Erbium: Yttrium Aluminium Garnet Laser

Conditions
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Chronic Periodontitis

Intervention / Treatment
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* Device: Ultrasonics
* Device: Gracey Curettes
* Device: Er:YAG Laser


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Greater than 25 years, Clinical diagnosis of moderate to advanced chronic periodontitis, Pocket depth ≥ 5 mm or clinic attachment level ≥ 4 mm at least in two interproximal areas (not on the same tooth), Along with very good oral hygiene scores (GI≤1and PI≤1), At least 4 teeth in each quadrant, Teeth with subgingival plaque sample is collected has no restoration or prothesis Exclusion Criteria: Periodontal treatment ( root planning or surgical periodontal treatment) had done before, Systemic disease that could influence the outcome of periodontal therapy, Prophylaxis regime mandatory during periodontal treatment, Use of any drug that could influence the outcome of periodontal therapy, Use of antibiotics within the last 3 months, Use of anti-inflammatory drugs within the last 3 months, Use of removable prothesis Pregnancy, lactation or use of hormone contraceptives, Smoking

Ages Eligible for Study
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Minimum Age: 28 Years
Maximum Age: 58 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Ultrasonics & Gracey Curettes<br>Scaling and root planning is done with ultrasonics and gracey curettes in 24 hours with two visits. | Device: Ultrasonics<br>* ultrasonic scalers<br>Device: Gracey Curettes<br>* Spesific gracey curettes<br>|
| Experimental: Ultrasonics & Gracey Curettes & Laser<br>Scaling and root planning is done with ultrasonics, gracey curettes and Er:YAG laser in 24 hours with two visits. | Device: Gracey Curettes<br>* Spesific gracey curettes<br>Device: Er:YAG Laser<br>* 2940 nm wavelenght Er:YAG laser<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Probing Pocket Depth 3 | to measure the probing pocket depth of all teeth | 3. month | 
| Clinic Attachment Level 3 | to measure the Clinic Attachment Level of all teeth | 3. month | 
| Subgingival Plak Sample 1 | quantitative changes on red complex bacterias | 1. month | 
| Probing Pocket Depth 6 | to measure theProbing Pocket Depth of all teeth | 6. month | 
| Clinic Attachment Level 6 | to measure the Clinic Attachment Level of all teeth | 6. month | 
| Subgingival Plak Sample 3 | quantitative changes on red complex bacterias | 3. month | 
| Subgingival Plak Sample 6 | quantitative changes on red complex bacterias | 6. month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Bleeding On Probing 3 | to record the Bleeding On Probing of all teeth | 3. month | 
| Bleeding On Probing 6 | to record the Bleeding On Probing of all teeth | 6. month | 
| Plak Index 3 | to record the plak index of all teeth | 3. month | 
| Plak Index 6 | to record the plak index of all teeth | 6. month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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chronic periodontitis, laser