Computed Tomography Perfusion Colorectal Cancer With Tumor Grade

Study Overview
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Brief Summary
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Colorectal cancer is the third most commonly diagnosed cancer in the world. The 5-years survival rate depends on the tumor stage and grade at patient presentation. Individual treatment strategy based on the tumor stage and grade should be applied to improve the prognosis, So the pre-operative diagnostic evaluation and grading of colorectal cancer are important.

Detailed Description
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Diagnosis of cancer colon is usually based on colonoscopy which provides direct visualization of the lesions and allows for biopsies. However the pre-operative specimens from endoscopic biopsies sometimes fail to grade tumor because of the lack of sufficient tissue. Recent improvements in computed tomography have allowed for minimally invasive evaluation of cancer colon. Quantitative iodine density measurement can be used to differentiate low and high grade colorectal cancer. However, debate continues regarding the correlation between tumor grade and computed tomography perfusion parameters of colorectal cancer demonstrating the need for further investigation in this area of research.

Official Title
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Computed Tomography Perfusion of Colorectal Cancer in Correlation With Tumor Grade

Conditions
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Colo-rectal Cancer

Intervention / Treatment
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* Radiation: Computed tomography perfusion


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Any patient with primary colorectal mass Exclusion Criteria: Colorectal mass pathologically proved to be benign Female patient at child bearing period with suspected pregnancy Raised renal chemistry Hypersensitivity to contrast.
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with colorectal adenocarcinoma<br>The patients will undergo computed tomography perfusion | Radiation: Computed tomography perfusion<br>* Pre-contrast images will be obtained to identify the colorectal tumor location. Then Fifty milliliters of iopromide (Ultravist ) will be injected intra-venously at rate of 5 milliliter per second via an automatic pump injector for computed tomography perfusion scans. Computed tomography perfusion scans will be performed at the mid-portion of the tumor for 60seconds beginning 5 seconds after contrast injection. Then arterial input will be defined by using the mouse to place a circular region of interest and the tumor region of interest will be placed on the most enhanced area of the tumor. Tumor blood flow, blood volume, mean transient time & permeability surface measurements will be obtained.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood flow of tumor | Accuracy of blood flow of the tumor in prediction of tumor grade in correlation with histopathological results | One month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood volume of the tumor | Accuracy of blood volume of the tumor in prediction of tumor grade in correlation with histopathological results | One month | 
| Mean transient time of the tumor | transient time of the tumor in prediction of tumor grade in correlation with histopathological results | One month | 
| Permeability surface of the tumor | Accuracy of permeability surface of the tumor in prediction of tumor grade in correlation with histopathological results | One month |