Impact of Hospitalization on High-sensitivity Cardiac Troponin T Concentrations Depending on Disease Severity

Study Overview
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Brief Summary
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We aim to examine, whether hospitalization is associated with higher high-sensitivity cardiac troponin T (hs-cTnT) serum concentrations in patients without a cardiac disease.

Detailed Description
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High-sensitivity cardiac troponin T (hs-cTnT) values will be obtained in hospitalized patients a) without a diagnosed or suspected cardiac disease, and b) with an acute medical condition that is not commonly associated with an increase of hs-cTnT concentrations. As a reference, a second sampling of blood for an analysis of the hs-cTnT serum concentration will be obtained in the same patients after discharge (60 days after hospitalization).

Official Title
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Impact of Hospitalization on High-sensitivity Cardiac Troponin T Concentrations Depending on Disease Severity (Inpatient Troponin T)

Conditions
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Non-cardiac Disease

Intervention / Treatment
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* Diagnostic Test: Analysis of hs-cTnT serum concentration at hospitalization
* Diagnostic Test: Analysis of hs-cTnT serum concentration after discharge


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: hospitalization due to a non-cardiac disease age ≥ 50 years Exclusion Criteria: diagnosed or suspected cardiac disease acute medical conditions commonly associated with a myocardial injury (e.g. circulatory shock, sepsis, pulmonary embolism, cerebral infarction, acute renal failure)

Ages Eligible for Study
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Minimum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with low disease severity<br>Hospitalized patients without a diagnosed or suspected cardiac disease and with an acute medical condition of low severity (e.g. patients with retinal detachment) | Diagnostic Test: Analysis of hs-cTnT serum concentration at hospitalization<br>* Analysis of the hs-cTnT serum concentration in the blood drawn at the day of hospitalization<br>Diagnostic Test: Analysis of hs-cTnT serum concentration after discharge<br>* Analysis of the hs-cTnT serum concentration in the blood drawn after discharge (60 days after hospitalization)<br>|
| Patients with medium disease severity<br>Hospitalized patients without a diagnosed or suspected cardiac disease and with an acute medical condition of medium severity (e.g. patients with an uncomplicated acute pancreatitis oder an acute exacerbation of a chronic inflammatory bowel disease) | Diagnostic Test: Analysis of hs-cTnT serum concentration at hospitalization<br>* Analysis of the hs-cTnT serum concentration in the blood drawn at the day of hospitalization<br>Diagnostic Test: Analysis of hs-cTnT serum concentration after discharge<br>* Analysis of the hs-cTnT serum concentration in the blood drawn after discharge (60 days after hospitalization)<br>|
| Patients with high disease severity<br>Hospitalized patients without a diagnosed or suspected cardiac disease and with an acute medical condition of high severity (e.g. patients with a proximal femoral fracture) | Diagnostic Test: Analysis of hs-cTnT serum concentration at hospitalization<br>* Analysis of the hs-cTnT serum concentration in the blood drawn at the day of hospitalization<br>Diagnostic Test: Analysis of hs-cTnT serum concentration after discharge<br>* Analysis of the hs-cTnT serum concentration in the blood drawn after discharge (60 days after hospitalization)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Difference of the hs-cTnT concentration at hospitalization and after discharge |  | 60 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Difference of the hs-cTnT concentration at hospitalization and after discharge in acute medical conditions of low severity |  | 60 days | 
| Difference of the hs-cTnT concentration at hospitalization and after discharge in acute medical conditions of medium severity |  | 60 days | 
| Difference of the hs-cTnT concentration at hospitalization and after discharge in acute medical conditions of high severity |  | 60 days | 
| Prediction of 1-year-mortality by hs-cTnT concentration |  | 1 year | 
| Prediction of 1-year-hospitalization rate due to a cardiovascular disease by hs-cTnT concentration |  | 1 year |