Risk Factors for Major Complications After Liver Resection

Study Overview
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Brief Summary
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The aim of this study is to determine the risk factors for major complications following liver resection in the setting of a general surgery-teaching department in Morocco, North Africa

Detailed Description
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Over the past 20 years, the refinement of liver surgery techniques, anesthesiology and perioperative management has dramatically improved the safety of liver resection patients. It has also led to a concomitant extension of indications for a growing number of patients with complex benign or malignant hepatobiliary diseases and/or high risk surgeries. Published complication rates and risk prediction models and recommendations for patients undergoing liver resection primarily stem from far East or Western high-volume specialized centers. In developing countries, including those in North Africa, specific constraints (e.g., endemic indications, such as liver cystic hydatidosis, blood shortage, and the scarcity of liver surgeons and intensive care providers) may impact liver resection outcomes but they are rarely addressed in the literature. The aim of this study was to determine the risk factors for major complications following liver resection in the setting of a general surgery-teaching department in Morocco, North Africa

Official Title
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Risk Factors for Major Complications After Liver Resection: Audit of a Non-Eastern/Non-Western Experience

Conditions
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Liver Diseases

Intervention / Treatment
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* Procedure: liver resection


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: all patients who underwent an hepatectomy between january 2010 and December 2015 Exclusion Criteria: All patient who only underwent liver biopsy with no resection Patients non operated

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: liver resection|Open or laparoscopic, major or minor hepatectomy performed using the clamp-crush technique and intermittent clamping of hepatic pedicle|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 90-day Mortality rate | Death within 90 days of surgical procedure | 90 days from surgery | 
| 90-day Complication rate | Defined by Clavien-Dindo grade I to IV within90 days of surgical procedure | 90 days from surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Risk factor of major complication at 90-day | defined by multivariate logistic regression of 90 day complication with Clavien-Dindo more than grade III | 90 days from surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Audit, Liver resection, Surgical complications, non-Eastern/non-Western, Quality improvement