The Effect of Hypercapnia on Physiological Parameters During Short-term Breathing

Study Overview
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Brief Summary
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The aim of the project is to evaluate the effect of hypercapnia on physiological parameters in a healthy person during short-term hypoxia and hypercapnia.

Detailed Description
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Hypercapnia causes changes in physiological parameters at various levels throughout the body. The study aims to evaluate the effect of hypercapnia on physiological parameters in a healthy person during short-term hypoxia and hypercapnia. It is an intervention prospective study that will be conducted at the Faculty of Biomedical Engineering on healthy volunteers. All the volunteers undergo three different phases in random order. The individual phases differ in the breathed mixture of oxygen, nitrogen and carbon dioxide gases. Non-invasive measurements of physiological parameters, especially blood oxygen saturation, perfusion index and cardiac output, will be performed continuously during the experiment.

Official Title
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The Effect of Hypercapnia and Hypoxia on Physiological Parameters During Short-term Breathing Experiment

Conditions
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Hypoxia, Hypercapnia, Cardiac Output, High

Intervention / Treatment
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* Other: Hypoxic
* Other: Hypercapnic
* Other: Hypoxic and Hypercapnic


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy volunteers Exclusion Criteria: pregnancy severe cardiovascular conditions severe asthma or other severe respiratory conditions injury to the upper limbs or hands that could affect the peripheral perfusion diabetes hypotension or hypertension

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Crossover Assignment
Interventional Model Description: Interventional single blinded randomized crossover prospective study. All participants go through all study arms, in random order.
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Hypoxic<br>Participants inhale ambient air, the hypoxic gas mixture, and ambient air. | Other: Hypoxic<br>* Hypoxic gas mixture Gas mixture of 10% O2 and 90% N2 for six minutes.<br>|
| Experimental: Hypercapnic<br>Participants inhale ambient air, the hypercapnic gas mixture, and ambient air. | Other: Hypercapnic<br>* Hypercapnic gas mixture Gas mixture of 21% O2, 5% CO2 74% N2 for six minutes.<br>|
| Experimental: Hypoxic and Hypercapnic<br>Participants inhale ambient air, the hypoxic and hypercapnic gas mixture, and ambient air. | Other: Hypoxic and Hypercapnic<br>* Hypoxic and Hypercapnic gas mixture Gas mixture of 10% O2, 5% CO2 85% N2 for six minutes.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in Cardiac output due to the induced hypoxia and hypercapnia | Based on the induced hypoxia, hypercapnia or combination of hypoxia and hypercapnia, Cardiac output will change | 1 hour | 
| Changes in Perfusion index due to the induced hypoxia and hypercapnia | Based on the induced hypoxia, hypercapnia or combination of hypoxia and hypercapnia, Perfusion index will change | 1 hour | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cardiac Output, Perfusion index, Pulse oximetry