Ridge Splitting With Simultaneous Implant Placement Using i-PRF

Study Overview
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Brief Summary
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Sohn introduced the concept of sticky bone in which i-PRF is mixed with the granules of bone graft, leading to fabrication of growth factors-enriched bone graft matrix using autologous fibrin glue. This minimizes bone loss and accelerates tissue healing during healing period. The present study was conducted to evaluate the clinical and radiographic outcomes following the application of the alveolar ridge splitting in combination with the use of guided bone regeneration (GBR) with or without i-PRF (sticky bone), associated with immediate implant placement in patients with horizontally atrophic jaw bones.

Official Title
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Ridge Splitting With Simultaneous Implant Placement Using i-PRF With Guided Bone Regeneration: a Randomized Clinical Trial

Conditions
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Ridge Splitting, i-PRF, Dental Implant

Intervention / Treatment
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* Procedure: Immediate implant placement and alveolar ridge splitting with GBR and i-PRF
* Procedure: Immediate implant placement and alveolar ridge splitting with GBR


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: good general health at the time of surgery. at least 3 months of healing after tooth extraction. horizontally compromised alveolar ridges at least 10 mm high and 3 mm wide. Exclusion Criteria: a vertical bone defect in the edentulous ridge. thick cortex in the labial/buccal with less cancellous bone inside obvious undercut on the labial/buccal side. uncontrolled periodontal conditions or other oral disorders. history of radiotherapy in the head and neck region. uncontrolled diabetes mellitus or other systematic disorders. smokers. Pregnancy. non-compliant patients. allergic reaction to the medications used

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: alveolar ridge splitting with GBR and i-PRF<br>alveolar ridge splitting in combination with the use of GBR with i-PRF (sticky bone) with immediate implant placement | Procedure: Immediate implant placement and alveolar ridge splitting with GBR and i-PRF<br>* Implant insertion and GBR for augmentation of the gap between buccal and lingual plate using bone graft mixed with i-PRF<br>|
| Active Comparator: alveolar ridge splitting with GBR<br>alveolar ridge splitting in combination with the use of GBR without i-PRF (sticky bone) with immediate implant placement | Procedure: Immediate implant placement and alveolar ridge splitting with GBR<br>* Implant insertion and GBR for augmentation of the gap between buccal and lingual plate<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measurements of the amount of bone formation in millimeters around immediately placed dental implants | Measurements of the amount of bone formation in millimeters using GBR with or without the combined effect of i-PRF in the ridge splitting following immediate implant placement. | 9 months |