Effect of Mannitol on Optic Nerve Sheath Diameter in Patients Undergoing Robotic Prostatectomy

Study Overview
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Brief Summary
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We aim to evaluate the change in optic nerve sheath diameters as a surrogate of intracranial pressure before and after mannitol administration in patients who undergo robot assisted laparoscopic radical prostatectomy with pneumoperitoneum and Trendelenburg position.

Detailed Description
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Mannitol has been frequently used for renal protection during surgery. Optic nerve sheath diameter is used to evaluate intracranial pressure noninvasively. Robot-assisted laparoscopic radical prostatectomy can induce an increase in optic nerve sheath diameter due to Trendelenburg position and carbon dioxide insufflation. We therefore aim to evaluate the change in optic nerve sheath diameters before and after mannitol administration in patients who undergo robot assisted laparoscopic radical prostatectomy.

Official Title
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Effect of Mannitol on Optic Nerve Sheath Diameter in Patients Undergoing Robot-assisted Laparoscopic Radical Prostatectomy: a Prospective Observational Study

Conditions
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Prostate Cancer

Intervention / Treatment
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* Drug: Mannitol


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: prostate cancer patients undergoing robot assisted laparoscopic radical prostatectomy. 20 year old or above, 79 year old or below. agreed to participate this study. Exclusion Criteria: history of cerebrovascular accident. history of congestive heart failure. history of pulmonary edema. history of anaphylaxis to mannitol. conversion to open prostatectomy. combined with other operation. inability to measure optic nerve sheath diameter.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 79 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Mannitol|The mannitol has been administered routinely to prevent renal dysfunction in patients undergoing robot-assisted laparoscopic radical prostatectomy. Participants will receive the mannitol as part of routine medical care, and we will evaluate the change in optic nerve sheath diameters before and after mannitol administration.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in optic nerve sheath diameters | Change in optic nerve sheath diameters before and after mannitol administration | 5 minutes after pneumoperitoneum and Trendelenburg position, 90 minutes after mannitol administration during pneumoperitoneum and Trendelenburg position | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in optic nerve sheath diameters | Change in optic nerve sheath diameters before and after mannitol administration | 5 minutes after pneumoperitoneum and Trendelenburg position, 60 minutes after mannitol administration during pneumoperitoneum and Trendelenburg position | 
| Change in optic nerve sheath diameters | Change in optic nerve sheath diameters before and after mannitol administration | 5 minutes after pneumoperitoneum and Trendelenburg position, 30 minutes after mannitol administration during pneumoperitoneum and Trendelenburg position | 
| Optic nerve sheath diameter | Optic nerve sheath diameter before mannitol administration | 10 minutes after induction of anesthesia | 
| Optic nerve sheath diameter | Optic nerve sheath diameter after mannitol administration | Intraoperative (during skin closure) |