Krill Oil Study Compared to Fish Oil

Study Overview
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Brief Summary
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The main purpose of the study is to evaluate the absorption of omega-3 fatty acids into the blood following consumption of krill oil compared with fish oil and placebo.

Detailed Description
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The main purpose of the study is to evaluate the absorption of omega-3 fatty acids into the blood following consumption of krill oil compared with fish oil and placebo. An additional purpose is to evaluate the lipid-lowering efficacy and safety of consumption of Krill Oil and Fish Oil to a placebo product. It has been shown that the ingestion of Krill Oil leads to better absorption of omega-3 fatty acids compared to ingestion of Fish Oil. It was also shown that consumption of krill oil and fish oil result in a favorable modification of lipid profiles. Therefore, it is anticipated that consumption of these krill oil and fish oil will improve lipid profile, as well as other health-related markers and will be safe and well tolerated.

Official Title
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Assessment of Bioavailability of Krill Oil Compared to Fish Oil in Healthy Volunteers

Conditions
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Healthy Volunteers

Intervention / Treatment
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* Dietary Supplement: Krill oil
* Dietary Supplement: Fish Oil


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: healthy men and premenopausal not pregnant or nursing women between 18 and 49 years old. Exclusion Criteria: smokers rheumatoid arthritis chronic illness cardiovascular problems dyslipidemia liver and kidney disease diabetes endocrine or metabolic disease inflammatory bowel disease pancreatitis gallbladder or biliary disease neurological/psychological disease bleeding disorders experienced platelet abnormalities gastrointestinal disorders that could interfere with fat absorption hypertension history of cancer an intention to lose weight use of anticoagulant serum triglycerides (TG) >200 mg/dL, and/or total cholesterol (TC) >240 mg/dL, and/or LDL-cholesterol (LDL-C) >160 mg/dL hypertension or lipid lowering medications consumption of more than one alcoholic drinks/day Consumption of more than one fish or seafood serving one month prior to the start of the study omega-6 fatty acids in the past 6 months planned to consume seafood products or fish or to use any omega-3 or omega-6 fatty acids nutritional supplements at anytime in the duration of the study planned to to become pregnant during the study period BMI>28 allergies to fish seafood or corn

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 49 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Krill Oil<br> | Dietary Supplement: Krill oil<br>* Krill oil:Total omega-3 fatty acids: 560-660 mg and Astaxanthin: 1800 µg<br>|
| Experimental: Fish Oil<br> | Dietary Supplement: Fish Oil<br>* Fish oil: Total omega-3 fatty acids: 560-660 mg<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Bioavailability |  | 1 month |