The Effectiveness and Safety of Resective Epilepsy Surgery for TRE

Study Overview
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Brief Summary
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Prospective controlled studies to identify clinical epilepsy control, cognitive changes, and safety in resective epilepsy surgery of tuberculosis-related epilepsy.

Detailed Description
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Control group: clear epilepsy focus in the brain, and medication has been continued. Surgery group: clear epilepsy focus in the brain, and resective epilepsy surgery for tuberculosis-related epilepsy. In order to ensure the follow-up of the study and 3 years after the end of the study, 100 cases were collected from each group of the study.

Official Title
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Clinical Evaluation of the Effectiveness and Safety of Resective Epilepsy Surgery for Tuberous Sclerosis Complex Related Epilepsy

Conditions
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Tuberous Sclerosis Complex, Epilepsy

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 2 years old and above, no gender restriction, TSC gene monitoring with or without abnormality Diagnosis of nodular sclerosis and epilepsy Epilepsy course for more than 1 year Patients who have taken 3 or more reasonable choices with appropriate and tolerable antiepileptic drugs (excluding mTOR inhibitors and traditional Chinese medicine and prescriptions) had seizures more than 12 times in the 3 months before enrollment The family members agreed to enroll and signed the informed consent. Exclusion Criteria： Obvious renal angiomyolipoma, pulmonary lymphoma leiomyomatosis, and subventricular giant cell astrocytoma Abnormal heart, lung, liver, and kidney functions and coagulation function The family did not sign the informed consent Preoperative evaluation, it is considered that no surgical treatment is needed The patient received other craniocerebral surgical treatment within 1 year during the follow-up period

Ages Eligible for Study
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Minimum Age: 2 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| % of patients with ILAE grading | The grading made by ILAE for the classification of outcome with respect to epileptic seizures following epilepsy surgery. It contains a total of 6 levels. The higher the level, the worse the result. We will count the percentage of patients at each level. | 3 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| IQ | Wechsler Preschool and Primary Scale of Intelligence（WPPSI-III），Wechsler Intelligence Scale for Children (WISC-IV) and Wechsler Adult Intelligence Scale (WAIS-IV)，3 scales will be used for different ages to measure IQ. Higher scores mean better outcomes. | 3 years | 
| Quality of Life: QOLIE-31 | QOLIE-31 is suitable for patients 14 years and older. QOLCE-76 is applied to patients aged 2-13 by parents. | 3 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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tuberous sclerosis complex, epilepsy, resective epilepsy surgery