Hemodynamic Repercussions of Noninvasive Ventilation

Study Overview
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Brief Summary
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The noninvasive ventilation (NIV) is a method of ventilatory support that does not require artificial airway. Its application is associated with complex hemodynamic repercussions, therefore is important to identify them for safety and effectiveness of the technique application. The main objective of this research is to evaluate the hemodynamic repercussions using doppler echocardiography in healthy volunteers submitted a different values of positive end expiratory pressure (PEEP) by the following ventilatory modes: Continuous positive airway pressure (CPAP) and Bilevel. The study hypothesis is that the positive end expiratory pressure (PEEP) may cause hemodynamic repercussions as: reduction of the ventricles pre-load, left ventricle after load, cardiac output and reduction in the diameter of the superior vena cava, due to the increase in the intrathoracic pressure and pulmonary volumes.

Official Title
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Evaluation of the Hemodynamic Repercussions of Non Invasive Ventilation in Healthy Individuals by Doppler Echocardiography

Conditions
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Haemodynamic Rebound

Intervention / Treatment
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* Other: Noninvasive ventilation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy individuals Age between 18 and 40 years old Non smoker Exclusion Criteria: Clinical signs or symptoms of any disease decompensation History of blood pressure variations by autonomic dysfunction Sense of claustrophobia Smoker

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Healthy volunteers<br>The volunteers initially underwent a clinical examination, spirometry and echocardiography to prove the health state. Then, different levels of positive end expiratory pressure (PEEP) is applied by the noninvasive ventilation in all individuals and the hemodynamic repercussions are evaluated by the doppler echocardiography | Other: Noninvasive ventilation<br>* Assess the hemodynamic repercussions of the positive end expiratory pressure applied noninvasively<br>* Other names: Positive end expiratory pressure;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hemodynamic repercussions of different levels of positive end expiratory pressure applied noninvasively, measured by echocardiography | The hemodynamic variables evaluated are: ventricular preload, left ventricle afterload, cardiac output, blood pressure and the vena cava's diameter. All variables will be assessed by echocardiography | 5 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measurement of cardiac output as a predictor of cardiopulmonary adaptation to different pressures. |  | 5 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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hemodynamic, mechanical ventilation, respiration with positive pressure