The Association of Protein-Energy Adequacy With Mortality in Critically Ill Patients With Acute Kidney Injury.

Study Overview
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Brief Summary
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This is a prospective observational single-center study in which the association of Protein-Energy Adequacy and 28-Days of Mortality among critically ill patients with Acute Kidney Injury, AKI will be investigated. The association of Protein-Energy adequacy with a length of ICU and hospital stay, total ventilator, and inotropic drug days among critically ill patients with AKI also will be investigated.

Detailed Description
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Patients with Acute Kidney Injury, AKI are probably more exposed to the risk of malnutrition especially if they undergo Renal Replacement Therapy, RRT. Optimization of nutrients especially energy and protein can ensure a better health outcome for critically ill patients with AKI. Moreover, there is no research on the association of Protein- Energy adequacy with mortality among critically ill patients with AKI in Malaysia. So, the main purpose of this study is to investigate the relationship of Protein-Energy adequacy with mortality among critically ill patients with AKI Subjects will be recruited upon admission in ICU after fulfilling the inclusion and exclusion criteria. They will be follow up from day 1 until day 14 or until ICU Discharge. Data including Demographic, Clinical, Laboratory, and Nutritional Status will be recorded. On Day 28, the outcome data including Mortality, length of ICU Stay, and Length of Ventilator day will be recorded.

Official Title
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The Association of Protein-Energy Adequacy With Mortality in Critically Ill Patients With Acute Kidney Injury. A Prospective Observational Single- Centre Study.

Conditions
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Critical Illness, Acute Kidney Injury

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients who are 18 years old and older Patients who are admitted to the participating ICU. Patients who are mechanically ventilated. Exclusion Criteria: Patients who are less than 18 years old End-stage renal disease patients Patients undergo kidney transplantation within 3 months before ICU admission Pregnant patients The patient is moribund with expected death within 24 hour or whom survival to 28 days is unlikely due to uncontrollable comorbidity (cardiac, pulmonary or hepatic end-stage disease; hepatorenal syndrome; poorly controlled cancer; severe post-anoxic encephalopathy and others) Prior treatment with RRT within 30 days Anticipated alive ICU discharge within 24 hours Readmission to the ICU during the same hospitalization episode.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 28-Days Mortality | Mortality status of subjects on day 28 from recruitment. | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Length of ICU Stay | Duration of ICU Stay from ICU admission until ICU discharge | 1 day | 
| Length of Ventilator Day | Duration of ventilator used by subjects from ICU admission until ICU discharge | 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Protein, Energy, Adequacy, Mortality