Comparison of Analgesic Effect of Volatile Anesthetics

Study Overview
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Brief Summary
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The purpose of this clinical trial is to compare analgesic effect of sevoflurane and desflurane at equal minimum alveolar concentrations using surgical pleth index.

Detailed Description
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Volatile anesthetics vary in their relative hypnotic potency. Recent studies demonstrated that equi-minimum alveolar concentration of various volatile anesthetic agents may produce different bispectral index values. However, the difference between analgesic effects of volatile anesthetics have not yet been investigated. The purpose of this clinical trial is to compare analgesic effect of sevoflurane and desflurane at equal minimum alveolar concentrations using surgical pleth index-guided remifentanil infusion.

Official Title
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The Comparison of Analgesic Effect of Volatile Anesthetics Using Surgical Pleth Index

Conditions
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Anesthesia

Intervention / Treatment
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* Drug: Sevoflurane
* Drug: Desflurane


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients undergoing balanced general anesthesia using volatile anesthetics and remifentanil patients with american society of anesthesiologist physical status I, II patients aged 19-65 years patients obtaining written informed consent Exclusion Criteria: patients with a history of any psychiatric or neurological disease patients who had received any medication affecting the central nervous system patients who had received medication affecting the sympathetic or parasympathetic nervous systems patients undergoing tracheal intubation for airway management pregnant women

Ages Eligible for Study
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Minimum Age: 19 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Sevoflurane<br>Anesthesia was maintained with sevoflurane. | Drug: Sevoflurane<br>* End-tidal concentration of sevoflurane was maintained at age-corrected 1 minimum alveolar concentration throughout the study period. The remifentanil infusion rate was adjusted using TCI pump to achieve surgical pleth index between 20 and 50.<br>* Other names: SEVO;|
| Experimental: Desflurane<br>Anesthesia was maintained with desflurane. | Drug: Desflurane<br>* End-tidal concentration of desflurane was maintained at age-corrected 1 minimum alveolar concentration throughout the study period. The remifentanil infusion rate was adjusted using TCI pump to achieve surgical pleth index between 20 and 50.<br>* Other names: DES;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Remifentanil consumption (µg/kg/min) |  | During the intraoperative period | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Target effective site concentration of remifentanil (ng/ml) |  | After at least 10 min of stable surgical pleth index values |