Sevoflurane Versus Desflurane for Catheter-related Bladder Discomfort

Study Overview
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Brief Summary
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We want to evaluate the efficacy of the sevoflurane and desflurane for the prevention of catheter-related bladder discomfort.

Detailed Description
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The mechanism of catheter-related bladder discomfort is thought to be related to the muscarinic receptor. The volatile anesthetics such as sevoflurane and desflurane are known to block the muscarinic receptor in different ways. We want to evaluate the efficacy of the sevoflurane and desflurane for the prevention of catheter-related bladder discomfort.

Official Title
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Comparison of the Effects of Sevoflurane and Desflurane on Prevention of Catheter-related Bladder Discomfort

Conditions
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Catheter Site Discomfort, Complications, Anesthesia, Urinary Bladder Neoplasms

Intervention / Treatment
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* Drug: Sevoflurane
* Drug: Desflurane


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients scheduled for transurethral bladder excision under general anesthesia ASA I-III Exclusion Criteria: Bladder outflow obstruction Overactive bladder End-stage renal disease Neurogenic bladder Heart failure Arrhythmia Morbid obesity Use of chronic analgesic medication Hepatic disease Pulmonary disease Psychiatric disease

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Sevoflurane<br>Sevoflurane will be administered as the maintenance agent of general anesthesia. | Drug: Sevoflurane<br>* Sevoflurane will be used.<br>|
| Active Comparator: Desflurane<br>Desflurane will be administered as the maintenance agent of general anesthesia. | Drug: Desflurane<br>* Desflurane will be used<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Catheter-related bladder discomfort | Catheter-related bladder discomfort will be measured for 24 hour postoperatively (0:none, 1:mild, 2:moderate, 3:severe). | 24 hour postoperatively | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Catheter-related bladder discomfort | Catheter-related bladder discomfort will be measured at 0, 1, 6 and 24 hour postoperatively (0:none, 1:mild, 2:moderate, 3:severe). | 0, 1, 6 and 24 hour postoperatively | 
| Nausea | The degree of nausea will be assessed as none, mild, moderate and severe at 0, 1, 6 and 24 hour postoperatively. | 0, 1, 6 and 24 hour postoperatively | 
| Vomiting | The degree of vomiting will be assessed as none, mild, moderate and severe at 0, 1, 6 and 24 hour postoperatively. | 0, 1, 6 and 24 hour postoperatively | 
| Dry mouth | Dry mouth after the admission of operating room will be assessed. (score:0-10) | 0 houe after admission of operating room |