NEURodevelopmental Outcome After Persistent Pulmonary Hypertension Of the Newborn

Study Overview
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Brief Summary
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Neonatal pulmonary hypertension is a rare but serious condition resulting from a lack of adaptation to extra-uterine life in some newborns. In the short term, the risk of death requires rapid and appropriate management of this transient pathology. In the long term, these newborns present a greater brain vulnerability, a consequence of the pathology itself with cerebral hypoxia but also invasive and aggressive therapies. Although current scientific evidence indicates a correlation with the existence of neurological developmental disorders, the understanding of the long-term neurological outcome of these babies remains poorly documented. Better knowledge of remote neuro-psychomotor development of the critical period

Official Title
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NEURodevelopmental Outcome in Children Between One and Five Years After Persistent Pulmonary Hypertension Of the Newborn

Conditions
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Persistent Pulmonary Hypertension of the Newborn

Intervention / Treatment
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* Other: Ages & Stages Questionnaires®, Third Edition (ASQ3)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All parenting authority holders of children aged 1 to 5 years, born after 34 weeks of amenorrhea and having been cared for neonatal PAH in paediatric resuscitation Exclusion Criteria: Holders of parental authority who cannot answer the questionnaire because they do not speak French. Opposition of one of the two holders of parental authority Minor parental authority holders Holders of parental authority under safeguarding of justice, guardianship or guardianship Newborns with neonatal PAH with an associated diagnosis of diaphragmatic hernia or cyanogenic congenital heart disease Newborns with neonatal PAH not treated with nitrogen monoxide

Ages Eligible for Study
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Minimum Age: 1 Year
Maximum Age: 5 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Persistent pulmonary hypertension of the newborn.<br>Children aged 1 to 5 years who have been hospitalized in pediatric resuscitation service for the treatment of persistent pulmonary hypertension of the newborn. | Other: Ages & Stages Questionnaires®, Third Edition (ASQ3)<br>* Investigators will propose to parents of children hospitalized for the treatment of persistent pulmonary hypertension of the newborn a hetero-evaluation via the validated ASQ questionnaire to analyze neuro-psychomotor development.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Describe the association between the occurrence of neuro-psychomotor developmental disorders and initial management in resuscitation. | Parents will complete ASQ3. The investigators will consider neuro-psychomotor developmental disorders in children with pathological ASQ questionnaire on at least 2 items. | Between one and 5 years after hospitalization in resuscitation. |