Contrastive Study for Minimally Invasive Cholecystolithotomy With Gallbladder Reservation and Laparoscopic Cholecystectomy

Study Overview
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Brief Summary
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To explore the therapeutic effects for treatment of cholecystolithiasis by minimally invasive cholecystolithotomy with gallbladder reservation and laparoscopic cholecystectomy. Method： patients with cholecystolithiasis who received minimally invasive Cholecystolithotomy with gallbladder reservation and patients with cholecystolithiasis who received laparoscopic cholecystectomy(LC) in The Affiliated Hospital of Guiyang Medical College from May 2011 to December 2013. Patients who received minimally invasive cholecystolithotomy with gallbladder reservation as trial group, patients who received LC as control group.the overall follow-up period is 1 year. Then the investigators statistically analyze improvement of cholecystolithiasis symptoms in every group, thickness of gall bladder wall, the gallbladder function and the rate of the recurrence of cholesterol gallstone in trial group.

Detailed Description
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The investigators Prospect： Minimally invasive cholecystolithotomy with gallbladder reservation is meaningful for recovering the function of gallbladder.

Official Title
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All the Phases Study Will be Operated by the Department of Hepatobiliary Surgery, The Affiliated Hospital of Guiyang Medical College

Conditions
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Gallstones

Intervention / Treatment
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* Procedure: minimally invasive cholecystolithotomy with gallbladder reservation
* Procedure: laparoscopic cholecystectomy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Clinical diagnosis of calculous cholecystitis. Exclusion Criteria: Gallbladder's wall >3mm, atrophied gallbladder,gallstone obstruct the Hartmann's pouch. Abdominal ultrasound display the contractibility of gallbladder is poor. The aged patients with bad heart and lung function. Patients who has acute cholecystitis,pancreatitis,pancreaticobiliary diseases, especially choledocholithiasis. Pregnant or lactational women.

Ages Eligible for Study
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Minimum Age: 12 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: gallbladder reservation<br>Patients in trial group all took minimally invasive cholecystolithotomy with gallbladder reservation | Procedure: minimally invasive cholecystolithotomy with gallbladder reservation<br> <br> |
| Experimental: laparoscopiccholecystectomy<br>Patients in control group all received LC. | Procedure: laparoscopic cholecystectomy<br> <br> * Other names: LC;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The contraction function of the gallbladder | Measure the participants' contraction function of gallbladder by the trial for contraction function of gallbladder | Participants will be followed for overall 1 year after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The thickness of gallbladder wall | Measure the participants' thickness of gallbladder wall by abdominal ultrasonography after surgery | Participants will be followed for overall 1 year after surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cholecystolithotomy with gallbladder reservation, cholecystolithiasis