Role of Basal Ganglia and Thalamus in Perceptual Consciousness and Metacognition

Study Overview
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Brief Summary
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The term perceptual awareness refers to subjective experience... or the phenomenology associated with the processing of a sensory stimulus. The term metacognition refers to our ability of introspection, knowledge and control of our own cognitive processes. The objective of this research is to establish the contribution of the basal ganglia and thalamus to the perceptual awareness and meta-cognition, using deep brain stimulation coupled with electroencephalography.

Official Title
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Role of Basal Ganglia and Thalamus in Perceptual Consciousness and Metacognition

Conditions
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Dystonia, OCD, Parkinson Disease

Intervention / Treatment
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* Device: deep brain stimulation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Major patient in need of brain stimulation therapy for motor disorders (Parkinson's disease, tremor, dystonia) or psychiatric disorders (OCD). Outpatient or inpatient follow-up Fluent in French and able to understand the study procedures informed consent Patient affiliated to social security Written agreement to participate in the patient's study Intellectual abilities compatible with the performance of cognitive or motor tasks Exclusion Criteria: Persons referred to in Articles L1121-5 to L1121-8 of the CSP (pregnant women, parturient women, mothers, etc.) who is breastfeeding, person deprived of liberty by judicial or administrative decision, person subject to a legal protection measure Patients in whom transient cessation of stimulation is not tolerated Subject in period of exclusion from another study Subject cannot be contacted in case of emergency Subject under administrative or judicial supervision

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Parkinson disease<br> | Device: deep brain stimulation<br>* Behavioral and electroencephalographic responses will be compared on and off deep brain stimulation<br>|
| essential tremor<br> | Device: deep brain stimulation<br>* Behavioral and electroencephalographic responses will be compared on and off deep brain stimulation<br>|
| dystonia<br> | Device: deep brain stimulation<br>* Behavioral and electroencephalographic responses will be compared on and off deep brain stimulation<br>|
| OCD<br> | Device: deep brain stimulation<br>* Behavioral and electroencephalographic responses will be compared on and off deep brain stimulation<br>|
| healthy volunteers<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Behavioral effect of DBS on confidence | Confidence in correct and incorrect responses will be compared on and off stimulation | by fall 2024 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Effect of DBS on EEG markers of confidence | EEG correlates of confidence in correct and incorrect responses will be compared on and off stimulation | by fall 2024 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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metacognition, consciousness, deep brain stimulation