Urinary Incontinence and Endocrine Factors. A Part of Lolland-Falster Health Study (LOFUS).

Study Overview
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Brief Summary
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Previous studies have shown an increase in the prevalence of urgency and urgency incontinence in women with diabetes. Regarding the condition urinary stress incontinence, the literature is diverted. The purpose of the PhD project is investigate the prevalence of urinary incontinence and the association to diabetes and thyroid disease in a mainly rual population in Lolland and Falster. Further to investigate if there is any difference in the bladder function in incontinent women with and without diabetes. Psychometric validation of the questionnaire used to assess urinary incontinence was also performed.

Official Title
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Urinary Incontinence and Endocrine Factors.

Conditions
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Urinary Incontinence, Diabetes, Thyroid Diseases

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: woman 18 years or above participating i The Lolland-Falster Health Study (NCT02482896) Exclusion Criteria: male below 18 years non-participating i The Lolland-Falster Health Study

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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Female

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prevalence of urinary incontinence | Assess by self-administered questionnaire and register data. Cross-sectional, measure once. The questionnaire International Consultation on Incontinence Questionnaire - Urinary Incontinence Short form (ICIQ-UI SF) was used to assess urinary incontinence (UI). It consist of six questions, and the score of three of the questions (assessing frequency of UI, volume of leak and bother) sums up to a total score. It ranges between 0-21 where 0 is no incontinence and a higher score indicates more severe symptoms of UI. The inclusion of participants are over a period of four years. | 4 years | 
| Psychometric validation of ICIQ-UI SF (questionnaire used to assess urinary incontinence) | We investigated the predictive validity, internal consistency, patient-interview agreement, construct validity, test-retest reliability, and sensitivity to change for the ICIQ-UI SF. | 2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Association between urinary incontinence and diabetes | Assess by self-administered questionnaire and register data. Cross-sectional, measure once. The inclusion of participants are over a period of four years. | 4 years | 
| Participants demographics | Assess by self-administered questionnaire and register data. Cross-sectional, measure once. The inclusion of participants are over a period of four years. | 4 years | 
| Objective characterization of urinary incontinence in women with and without diabetes | Assess by urodynamics studies. Description of type of urinary incontinence, first sensation (ml), normal desire (ml), urgency (ml), max capacity (ml) and PVR (ml). Measured once for each participants. Data collected over a period of two years. | 2 years |