linjc16/ctgov huggingface dataset:
Attention Deficit Disorder and Exposure to Lead

Study Overview
=================
Brief Summary
-----------------
We are examining the past exposure to lead in 250 well characterized children with ADHD, and a suitable group of controls. Our measure of past exposure is bone lead levels obtained by XRay fluorescence spectroscopy, a relatively new way of estimating bone lead concentrations, and by inference, body lead burdens. By comparing the lead concentrations in these two groups, controlling for other factors which could confound, we will estimate odds ratios for ADHD given elevated bone lead, and estimate the contribution of lead to this disease of childhood.

Conditions
-----------------
Attention Deficit Disorder

Participation Criteria
=================
Eligibility Criteria
-----------------
Case subjects are drawn from adolescents aged 10 to 18 previously seen at Western Psychiatric Institute and Clinic for evaluation, and meet the DSM-IIIR criteria for diagnosis of ADHD based on a structured parent interview and standardized parent and teacher rating scales. Cases were also systematically observed and evaluated in the summer treatment program between 1987 and 1996 at WPIC. Controls are demographically matched non-ADHD adolescents, recruited from surrounding communities and pediatric practices.

Ages Eligible for Study
-----------------
Minimum Age: 10 Years
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Lead exposure, Bone lead, Attention deficit
Collection Of Tissue, Blood, and Other Specimens From Patients With Head and Neck Tumors To Study the Causes, Diagnosis, Prevention and Treatment of Cancers

Study Overview
=================
Brief Summary
-----------------
This is a protocol to collect tissues, blood, and other specimens from patients with malignant or nonmalignant diseases of the head and neck. Collected specimens will be used in laboratory studies to investigate the growth, development, and transformation of normal and abnormal cells in the future.

Detailed Description
-----------------
This is a protocol to collect tissues, blood, and other specimens from patients with malignant or nonmalignant diseases of the head and neck. Collected specimens will be used in laboratory studies to investigate the growth, development, and transformation of normal and abnormal cells in the future.

Official Title
-----------------
Collection of Tissue, Blood, and Other Specimens From Patients With Head and Neck Diseases to Study the Causes, Diagnosis, Prevention and Treatment of Cancers

Conditions
-----------------
Head and Neck Cancers

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with head and neck diseases are eligible if they have had tissue, serum, urine, or other specimens removed or collected for diagnostic or therapeutic purposes. Patients will be entered onto this protocol without preference for any racial or ethnic group. Patients may have received prior chemotherapy, radiation, surgical therapy, immunotherapy, or differentiation therapy. The specimen collected must be large enough to allow conventional testing necessary for patient care, with the portion of the specimen reserved for research laboratory analysis excised from residual tissue that would otherwise have been discarded. Exclusion Criteria: Patients not giving informed consent will be excluded.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>Patients with head and neck cancers | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Collect tissues, blood, and other specimens from patients with malignant or nonmalignant diseases of the head and neck. Specimens will be used to investigate growth, development, and transformation of normal and abnormal cells in the future. |  | 36 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
HEENT cancers, larynx, thyroid, sarcoma, specimen analysis
Atorvastatin in Myeloma

Study Overview
=================
Brief Summary
-----------------
The purpose of this trial is to study the effects of a medication already widely used to treat cardiovascular disease and diabetes, in reducing the progression of myeloma.

Conditions
-----------------
Myeloma

Intervention / Treatment
-----------------
* Drug: atorvastatin


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Myeloma in remission Exclusion Criteria: Adverse events (AEs) to statin, already on a statin, or contraindication to statin

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: atorvastatin|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Screening in Myocardial Perfusion Patients

Study Overview
=================
Brief Summary
-----------------
To expand the understanding of the uptake and distribution of Tc-99m sestamibi in the breast in a normal female population undergoing myocardial perfusion imaging using Molecular Breast Imaging (MBI).

Detailed Description
-----------------
You are being asked to take part in this research study because you have been scheduled to have a scan of your heart. The radioactive dye used to image your heart is also taken up by many types of breast cancer. The investigators have developed a new method for detecting breast cancer, called Molecular Breast Imaging that uses this dye. The purpose of this study is to see how well this new method works in normal subjects with no known breast cancer and to see if we can detect breast cancer at an earlier stage than mammography. As you read this form describing the study, ask any questions you have. Take your time to decide. Feel free to discuss the study with your family, friends, and healthcare provider before you decide. You may stop participating at any time during the study. You may decide not to participate. If so, none of your current benefits or normal health care will be affected in any way. When you feel comfortable that all your questions have been answered, and you wish to take part in this study, sign this form in order to begin your participation. Your signature means you have been told about the study and what the risks are. Your signature on this form also means that you want to take part in this study.

Official Title
-----------------
Screening for Breast Cancer in Patients Undergoing Myocardial Perfusion Imaging

Conditions
-----------------
Breast Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: They have had a mammogram at Mayo Clinic Rochester within the last 12 months Undergoing myocardial perfusion imaging Exclusion Criteria: They are unable to understand and sign the consent form They are physically unable to sit upright and still for 20 minutes They have undergone breast surgery or breast biopsy within the last 12 months. They have had trauma to the breast tissue or undergone radiation treatment to the breast within the last 12 months.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Biopsy-proven breast cancer |  | 12 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Breast, Breast Cancer, MBI, Molecular Breast Imaging, Molecular Imaging
Efficacy Study of Fine Needle Technique on Calcific Tendinitis

Study Overview
=================
Brief Summary
-----------------
Background: Calcific tendinitis of the rotator cuff may cause chronic pain at the shoulder. Sometimes the pain can lead to a serious impairment in the daily life. One of the most efficient treatments is percutaneous needle aspiration using ultrasound guidance. This treatment includes identification the tendonitis with US or screening , local anesthesia and then puncturing the calcium in the rotator cuff many times. The treatment is short 5-10 minutes, relatively cheap ,safe and usually with good outcomes. However in the literature there is a lack of controlled prospective trials. Our goal is to set a study that will evaluate this treatment between two groups: Puncturing the calcium in the rotator cuff 15 times (the experiment group) Puncturing the calcium in the rotator cuff twice (the controlled group)

Official Title
-----------------
Phase 2 Study of the Fine Needle Technique on Calcific Tendinitis

Conditions
-----------------
Tendinitis

Intervention / Treatment
-----------------
* Procedure: fine needle technique


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age 18 and above. 6 months of pain in the shoulder. Positive IMPING and sensitivity on SST. Calcification above 1 cm in one of the dimensions by US or aray of the shoulder. Completed conservative treatment: physiotherapy or analgesics. Exclusion Criteria: Diabetes, Nephrological diseases RC tear according to US. Prior operation in this shoulder Steroids injection in the last three months. A patient that is in the absorption phase of the tendinitis Pregnancy Coagulation System impairments

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: fine needle technique|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Calcific Tendinitis
The Effect on Function of Increasing Activity for Nursing Home Residents

Study Overview
=================
Brief Summary
-----------------
As designs of existing outcome studies are disparate and do not always relate well to a Swedish context, the need for further studies is obvious. Also, an empirical theory drawn from the best practice supporting autonomy and wellbeing for clients in a nursing home setting has not yet been fully depicted. The study described below intends to fill a gap in knowledge related to the effect of enhanced activities of daily living (ADL)-training, physical, and daily activities and staff education in a nursing home setting, based on a theory- and evidence-based intervention programme in a Swedish as well as a Nordic health care context. The aims of the study are to describe the impact of an individually tailored intervention program, in a nursing home setting, on: Physical capacity Degree of dependence in ADL Long-term participation in physical and/or daily activities Self-rated wellbeing

Detailed Description
-----------------
The Trondheim study has additional aims to assess the impact of intervention on: Urinary incontinence Falls

Official Title
-----------------
Physical and Daily Activity for Residents in a Nursing Home Setting. -A Nordic Multi-Centre Study

Conditions
-----------------
Frailty, Nursing Home Residents

Intervention / Treatment
-----------------
* Behavioral: Individualized exercise


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: > 65 years of age Expected stay in the nursing home > 3 months Able to take instruction Exclusion Criteria: Persons in a terminal phase

Ages Eligible for Study
-----------------
Minimum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: exercise group<br>individualized exercise | Behavioral: Individualized exercise<br>* individualized exercise, physical activity and training in daily life situations given by trained physical therapists and occupational therapists<br>|
| No Intervention: control group<br>care as usal | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Physical function |  | baseline, three and six months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Falls |  | during six months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
exercise, functioning, frail elderly
Hepatitis C Screening in the Primary Care Setting

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine whether patient education improves Hepatitis C screening in the primary care setting.

Detailed Description
-----------------
Hepatitis C is a chronic, asymptomatic infection that progresses to liver cirrhosis and cancer in the later stages if left untreated. The Centers for Disease Control (CDC) recommends a one-time screening for high risk birth cohort between the years 1945-1965. Prior studies have evaluated methods to improve screening for hepatitis c with focus on increasing awareness in health professionals. Targets included nursing staff and electronic medical records. This study targets providing patients with education resources to see if screening rates improve.

Official Title
-----------------
Prospective Cohort Study: Hepatitis C Screening in the Primary Care Setting

Conditions
-----------------
Hepatitis C

Intervention / Treatment
-----------------
* Diagnostic Test: Hepatitis C Antibody


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All patients born between the years 1945 and 1965. Exclusion Criteria: Patients who had already received a prior screening test for Hepatitis C before the office visit.

Ages Eligible for Study
-----------------
Minimum Age: 50 Years
Maximum Age: 71 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Date of birth<br>Those people born within the years 1945-1965 | Diagnostic Test: Hepatitis C Antibody<br>* Patients who received a blood test to screen for the Hepatitis C virus.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of Patients Screened for Hepatitis C | Change from baseline in number of patients from high-risk birth cohort screened for Hepatitis C during intervention period. | June 2016 to October 2016. | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Public Health, Patient Education as Topic, Hepatitis C
Non-invasive Nerve Stimulation for PTSD and Sleep

Study Overview
=================
Brief Summary
-----------------
In this study, our objective is to determine the effect of two different nerve stimulation types in changing sleep architecture.

Detailed Description
-----------------
Persons suffering from PTSD or mild TBI may suffer from sleep deprivation. The purpose of this study is to explore options to improve sleep quality.

Official Title
-----------------
Non-invasive Vagal Nerve Stimulation and Sleep

Conditions
-----------------
Post Traumatic Stress Disorder, Traumatic Brain Injury

Intervention / Treatment
-----------------
* Other: Transcutaneous nerve stimulation location 1
* Other: Transcutaneous nerve stimulation location 2


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: veterans with history of PTSD with and without history of mild TBI Exclusion Criteria with: history of severe psychiatric illness unrelated to PTSD or TBI other medical conditions of severity that may impair cognition current illicit or prescription drug abuse breathing disorder requiring constant use of oxygen

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Noninvasive nerve stimulation type I<br>This group will receive one type of nerve stimulation | Other: Transcutaneous nerve stimulation location 1<br>* Non-invasive stimulation by transcutaneous electrical nerve stimulation device in test location<br>Other: Transcutaneous nerve stimulation location 2<br>* Stimulation will be performed using electrodes placed in alternate location.<br>|
| Active Comparator: Noninvasive nerve stimulation type II<br>This group will receive second type of nerve stimulation | Other: Transcutaneous nerve stimulation location 1<br>* Non-invasive stimulation by transcutaneous electrical nerve stimulation device in test location<br>Other: Transcutaneous nerve stimulation location 2<br>* Stimulation will be performed using electrodes placed in alternate location.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Physiological sleep architectural quality | Polysomnography | up to 8 hours | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Nerve stimulation, sleep deprivation
Socket Preservation With Er:YAG and Nd:YAG Lasers

Study Overview
=================
Brief Summary
-----------------
Alveolar bone regeneration after laser-assisted extraction will be compared with bone regeneration after standard extraction procedure.

Official Title
-----------------
Post-extraction Treatment With Er:YAG and Nd:YAG Lasers - Socket Preservation

Conditions
-----------------
Post-extraction Bone Regeneration

Intervention / Treatment
-----------------
* Device: Er:YAG and Nd:YAG lasers
* Procedure: Standard extraction


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patient requires at least one simple extraction Voluntary informed consent to participate in the study Exclusion Criteria: Pregnancy Use of photosensitizing medication Refuse participation Require complicated extraction

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Patients will be randomly assigned to either laser or control group.
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Laser<br>After extraction, Er:YAG and Nd:YAG lasers used for degranulation, disinfection, deepithelialization, clot stabilization and photobiomodulation. | Device: Er:YAG and Nd:YAG lasers<br>* Extraction followed by Er:YAG laser degranulation, Nd:YAG laser disinfection, Er:YAG deepithelialization, Nd:YAG blood clot stabilization and photobiomodulation. The photobiomodulation step repeated on day 3, 5, and 7.<br>* Other names: Fotona;|
| Active Comparator: Control<br>Standard extraction procedure. | Procedure: Standard extraction<br>* Standard extraction procedure<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in bone density from immediate post-extraction | Cone Beam Computed Tomography (CBCT) | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Bone density | Cone Beam Computed Tomography (CBCT) | 3 months | 
| Bone thickness | Cone Beam Computed Tomography (CBCT) | 3 months | 
| Treatment pain | On a pain scale from 0 (no pain) to 10 (intolerable pain) | day 1 | 
| Treatment pain | On a pain scale from 0 (no pain) to 10 (intolerable pain) | day 3 | 
| Treatment pain | On a pain scale from 0 (no pain) to 10 (intolerable pain) | day 5 | 
| Treatment pain | On a pain scale from 0 (no pain) to 10 (intolerable pain) | day 7 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
tooth extraction, alveolar bone, bone regeneration, laser