A Comparison of Temperature Measurement During Living Donor Liver Transplantation

Study Overview
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Brief Summary
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The purpose of this study is to compare the temperature measured from the cuff surface of the endotracheal tube and core temperature measured at the esophagus in living donor liver transplantation recipients.

Detailed Description
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Hypothermia occurs frequently in patients undergoing surgery and is known to be related with many postoperative complications. Patients undergoing living donor liver transplantation are usually monitored using an esophageal stethoscope. However, because patients with liver cirrhosis have the risk of variceal bleeding, placement of an esophageal stethoscope can increase the risk of bleeding. There have been previous reports that temperature monitoring at the cuff surface of an endotracheal tube is not only safe but also provides accurate and reliable data during mild hypothermia after cardiac arrest. This study compares the temperature measured from the cuff surface of the endotracheal tube and core temperature measured at the esophagus and additionally core temperature measured by a pulmonary artery catheter. The study participants are intubated with an endotracheal tube that has a temperature sensor at the cuff surface of the tube. The rest of the procedure is done according to Seoul National University Hospital's protocol for liver transplantation: an esophageal stethoscope is placed for temperature monitoring and a central line is placed with a Multi-Access lumen Catheter and a pulmonary artery catheter is placed. The temperature measurements from the endotracheal tube and measurements from the esophageal stethoscope are compared at the following 5 phases: 1. preanhepatic phase, 2. anhepatic phase 1 (recipient hepatectomy - IVC clamping), 3. anhepatic phase 2 (IVC clamping - reperfusion), 4. Reperfusion phase, 5. Neohepatic phase.

Official Title
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A Comparison of Body Temperature Measured From the Cuff Surface of the Endotracheal Tube and Core Temperature in Living Donor Liver Transplantation

Conditions
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Living Donor Liver Transplantation

Intervention / Treatment
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* Other: Tracheal Temperature


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: routine living donor liver transplantation recipients needing pulmonary artery catheterization who have been informed and given consent Exclusion Criteria: -

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Tracheal Temperature<br>Intubation done with a temperature sensor located on the cuff surface of the endotracheal tube | Other: Tracheal Temperature<br>* Temperature measured from the endotracheal tube compared with the esophageal temperature<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of temperature from the cuff surface of the endotracheal tube and esophageal temperature | temperature | Phase 1 (preanhepatic): 60 minutes after the anesthetic induction | 
| Comparison of temperature from the cuff surface of the endotracheal tube and esophageal temperature | temperature | Phase 2 (anhepatic 1): 10 minutes after recipient hepatectomy | 
| Comparison of temperature from the cuff surface of the endotracheal tube and esophageal temperature | temperature | Phase 3 (anhepatic 2): 10 minutes after IVC clamping | 
| Comparison of temperature from the cuff surface of the endotracheal tube and esophageal temperature | temperature | Phase 4 (Reperfusion): 5 minutes after Reperfusion | 
| Comparison of temperature from the cuff surface of the endotracheal tube and esophageal temperature | temperature | Phase 5 (neohepatic): 1 hour after Reperfusion | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of temperature from the cuff surface of the endotracheal tube and temperature measured at the pulmonary artery catheter | temperature | Phase 1 (preanhepatic): 60 minutes after the anesthetic induction | 
| Comparison of temperature from the cuff surface of the endotracheal tube and temperature measured at the pulmonary artery catheter | temperature | Phase 2 (anhepatic 1): 10 minutes after recipient hepatectomy | 
| Comparison of temperature from the cuff surface of the endotracheal tube and temperature measured at the pulmonary artery catheter | temperature | Phase 3 (anhepatic 2): 10 minutes after IVC clamping | 
| Comparison of temperature from the cuff surface of the endotracheal tube and temperature measured at the pulmonary artery catheter | temperature | Phase 4 (Reperfusion): 5 minutes after Reperfusion | 
| Comparison of temperature from the cuff surface of the endotracheal tube and temperature measured at the pulmonary artery catheter | temperature | Phase 5 (neohepatic): 1 hour after Reperfusion | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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core temperature, esophageal temperature, tracheal temperature