Combination of Preoperative Gabapentin and TAP Blocks in Decreasing Postoperative Pain

Study Overview
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Brief Summary
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There is an increasing trend on decreasing narcotic use and maximizing efficiency in the perioperative care. There are no studies that have compared a TAP block versus a TAP block plus gabapentin for laparoscopic procures.This study will investigate if taking gabapentin and receiving a TAP block decrease post-operative morphine consumption. It will be a randomized controlled, double blind study, with 130 patients between 18-60 years; that will undergo laparoscopic GYN procedures. Secondary outcomes will look at the incidence of nausea, vomiting, and VAS (verbal analog scale) scores. This combination may be helpful because gabapentin will be used to decrease visceral and central pain, and TAP block will decrease somatic pain. Performing a multimodal approach may decrease narcotic consumption, adverse effects and improve pain management.

Official Title
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Combination of Preoperative Gabapentin and TAP Blocks in Decreasing Postoperative Pain

Conditions
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Postoperative Pain

Intervention / Treatment
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* Drug: Gabapentin
* Procedure: TAP Block


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: female receiving laparoscopic GYN procedure between 18-60 Exclusion Criteria: are already taking gabapentin have diabetic neuropathy have a chronic pain syndrome take opioids at home are pregnant have kidney disease have an allergy to morphine

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: TAP Block plus placebo<br>Patients will only receive a TAP block procedure and then morphine consumption will be recorded. | Procedure: TAP Block<br>* a procedure done anesthetize the anterior abdominal wall<br>|
| Experimental: TAP Block plus gabapentin<br>Patients will receive a TAP block procedure and take pre-operative oral Gabapentin and morphine consumption will me recorded after surgery. | Drug: Gabapentin<br>* anticonvulsant drug that is used for neuropathic pain.<br>* Other names: Neurontin;Procedure: TAP Block<br>* a procedure done anesthetize the anterior abdominal wall<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Post-operative morphine consumption | Total amount of morphine the patient need to control post-operative pain | 24 hours after surgery. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| VAS Scores | Visual analog scale that rates a patient's pain | 24 hours after surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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gabapentin, TAP block