A Prospective Randomized Trial Comparing Partial Hepatectomy and TACE Plus PEI for Small Hepatocellular Carcinoma

Study Overview
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Brief Summary
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Presently,the diagnostic method of small hepatocellular carcinoma has been greatly elevated in China.The treatment is being from simplification to diversification,from entirety to individualization.Confronting small hepatocellular carcinoma,we not select simple operation treatment but select a treatment that have more predominance and more fitting with patients in various kinds of treatment methods;including operation ,TACE,PEI,et al.which is better ? There are many arguments.

Detailed Description
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randomly put in group standard: via clinical diagnosis and confirm it is primary liver cancer, and not accept any anticancer treatment. age: 18-70 years. early hepatocyte cancer，which is single focus of infection diameter ≤ 3 cm. estimate tumor can gain treatment of curing operation or TACE plus PEI. better liver function (Child-Pugh，class A or B). Case loads: 160 residents with small hepatocellular carcinoma in China Therapeutic regimen: under normal rules, the operation group open abdomen to perform operation through subtotal incision while the patient has been general anesthesia with trachea cannula. The operation range on hepatic tissue of un-tumor tissue around tumor should maintain at least 1cm. As for the micro-create treatment combination group, taking TACE all through arteria cruralies super-elect arteria hepatica and injecting MITO、FUDR、iodipin. By B transonogram guiding to nyxis liver biopsy,and perform per cutem absolute alcohol injection treatment. Research end-point: ensemble life span.To compare 1、2 and 3 year overall survival rate in hepatectomy and TACE plus PEI for small hepatocellular carcinoma intraliver recurrence rate; distant metastasis rate; non-tumor life span; band tumor life span Telephone call at any time

Official Title
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A Prospective Randomized Trial Comparing Partial Hepatectomy and TACE Plus PEI for Small Hepatocellular Carcinoma

Conditions
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Hepatocellular Carcinoma

Intervention / Treatment
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* Other: operation;TACE plus PEI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: via clinical diagnosis and confirm it is primary liver cancer, and not accept any anticancer treatment. age:18-70years early hepatocyte cancer，which is single focus of infection diameter ≤3cm. estimate tumor can gain treatment of curing operation or micro-create treatment combineation better liver function (Child-Pugh，class A or B) Exclusion Criteria: reject to attend； impossible to come to our hospital for physical examination regularly. cancer epitome、seed focus、lymph node or distant metastasis Blood clotting function hindrance; serious heart、lung、kidney disease.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: survival rate<br>therapeutic effect of partial hepatectomy or TACE plus PEI for small hepatocellular carcinoma | Other: operation;TACE plus PEI<br>* Under normal rules, the operation group open abdomen to perform operation through subtotal incision while the patient has been general anesthesia with trachea cannula. The operation range on hepatic tissue of un-tumor tissue around tumor should maintain at least 1cm. As for the micro-create treatment combination group, taking TACE all through arteria cruralies super-elect arteria hepatica and injecting MITO、FUDR、iodipin. By B transonogram guiding to nyxis liver biopsy,and perform per cutem absolute alcohol injection treatment.<br>* Other names: surgical resection;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| overall survival |  | 2010 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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small hepatocellular carcinoma, partial hepatectomy, TACE plus PEI