A Study of Cirmtuzumab and Ibrutinib in Patients With B-Cell Lymphoid Malignancies

Study Overview
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Brief Summary
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This is Phase 1b/2 study to investigate the safety and effectiveness of the investigational drug, cirmtuzumab, when given in combination with ibrutinib in patients with B-cell lymphoid malignancies. Cirmtuzumab is a monoclonal antibody that attaches to a protein (called ROR 1) that is found on hematologic tumor cells. ROR1 has been shown to play a role in cell signaling that cause leukemia and lymphoma cells to grow and survive. ROR1 is rarely found on healthy cells.

Detailed Description
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This is a Phase 1b/2 study to investigate the safety and effectiveness of the investigational drug, cirmtuzumab (INN:zilovertamab), when given in combination with ibrutinib in patients with B-cell lymphoid malignancies. The Phase 1b will be conducted in two parts (Part 1 and Part 2). Part 1 is a dose-finding evaluation of the sequential administration of cirmtuzumab monotherapy followed by cirmtuzumab and ibrutinib combination therapy in chronic lymphocytic leukemia /small lymphocytic leukemia (CLL/SLL), previously treated mantle cell lymphoma (MCL) subjects that are BTKI naiive or have received a prior Bruton tyrosine kinase (BTK) inhibitor therapy, unless they demonstrated primary or acquired resistance to BTKi. Up to 48 subjects will be enrolled in Part 1 to determine the recommended dosing regimen (RDR). In Part 2, up to 60 subjects (CLL/SLL, MCL and MZL (marginal zone lymphoma) will be enrolled to further evaluate the safety and pharmacology of the cirmtuzumab and ibrutinib combination given at the RDR determined in Part 1 of the study. MZL subjects that have been previously treated and have relapsed after or progressed during at least one prior anti-CD20 -based therapy will be evaluated. In the Phase 2 (Part 3) portion of the study, approximately 30 subjects with CLL/SLL who may have received minimal prior BTK inhibitor therapy will be randomized to either Arm 1 (cirmtuzumab and ibrutinib) at the RDR or Arm 2 (ibrutinib alone) to evaluate the clinical activity and safety of the two arms.

Official Title
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A Phase 1b/2 Study of the ROR1-Targeting Monoclonal Antibody, Cirmtuzumab (UC-961), and the Bruton Tyrosine Kinase Inhibitor, Ibrutinib, in Patients With B-Cell Lymphoid Malignancies

Conditions
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B-cell Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Mantle Cell Lymphoma, Marginal Zone Lymphoma

Intervention / Treatment
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* Drug: Cirmtuzumab (2-16 kg/mg) plus Ibrutinib
* Drug: Cirmtuzumab (300mg) plus Ibrutinib
* Drug: Cirmtuzumab (600 mg) plus ibrutinib
* Drug: Cirmtuzumab (RDR) plus ibrutinib
* Drug: Cirmtuzumab plus ibrutinib
* Drug: Ibrutinib alone


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Men and women of age ≥18 years. ECOG performance status of 0, 1, or 2 Histological diagnosis of CLL/SLL, MCL or MZL (including splenic,nodal and extranodal subtypes) as documented in medical records (pathology reports and slides or blocks should be available for review or additional testing). MCL has been previously treated and has relapsed after or progressed during prior therapy. CLL/SLL may have been previously treated or are treatment naïve but now require therapy. MZL has been previously treated and has relapsed after or progressed during at least one prior anti-CD20 -based therapy A medically appropriate candidate for ibrutinib treatment (based on the judgement of the clinical investigator). Patients who have received prior BTK inhibitor therapy are eligible, unless they demonstrated primary or acquired resistance to a BTK inhibitor or experienced a serious or severe adverse event attributed to BTK inhibitor therapy. Presence of radiographically measurable lymphadenopathy or extranodal lymphoid malignancy (defined as the presence of ≥1 non-biopsied, non-irradiated lesion that measures >1.5 cm in the longest dimension [LD] and ≥1.0 cm in the longest perpendicular dimension [LPD] as assessed by computed tomography [CT] or magnetic resonance imaging [MRI]). Current medical need for therapy due to disease-related symptoms, lymphadenopathy, organomegaly, extranodal organ involvement, or progressive disease. Completion of all previous therapy (including any Bcl-2 or PI3K inhibitor therapy, surgery, radiotherapy, chemotherapy, immunotherapy, or investigational therapy) for the treatment of cancer ≥1 week (or ≥3 half-lives of the previous drug) before the start of study therapy. All acute toxic effects of any prior antitumor therapy resolved to Grade ≤1 before the start of study therapy (with the exceptions of alopecia, or neurotoxicity [Grade 1 or 2 permitted], or selected laboratory parameters [Grade 1 or Grade 2 permitted with exceptions as noted below]). Adequate bone marrow function: Absolute neutrophil count (ANC) ≥1.0 × 109/L. Platelet count ≥50 × 109/L. Hemoglobin ≥8.0 g/dL maintained for ≥1 week from any prior transfusion. Adequate hepatic profile: Serum alanine aminotransferase (ALT) ≤3 × upper limit of normal (ULN). Serum aspartate aminotransferase (AST) ≤3 × ULN. Serum bilirubin ≤1.5 × ULN unless elevated due to Gilbert syndrome. Adequate renal function: Estimated creatinine clearance (eClCR) >30 mL/minute (with eClCR to be calculated by the Cockcroft-Gault formula [see Appendix 12.2]), or Measured creatinine clearance >30 mL/minute (as assessed with a 24-hour urine collection). Adequate coagulation profile: Prothrombin time (PT) ≤1.5 × ULN. Activated partial thromboplastin time (aPTT) ≤1.5 × ULN. Negative viral serology: Negative human immunodeficiency virus (HIV) antibody. Negative hepatitis B surface antigen (HBsAg) and negative hepatitis B core (HBc) antibody or undetectable hepatitis B (HBV) deoxyribonucleic acid (DNA) by quantitative polymerase chain reaction (PCR) testing. Negative hepatitis C virus (HCV) antibody or negative HCV RNA by quantitative PCR. For female patients of childbearing potential, a negative urine or serum pregnancy test prior to the start of study therapy. For female patients of childbearing potential, willingness to use a highly effective method of contraception from the start of the screening period until ≥3 months after the last dose of cirmtuzumab and ≥1 month after the last dose of ibrutinib, whichever is later. Note: A female patient is considered to be of childbearing potential unless she has had a hysterectomy, bilateral tubal ligation, or bilateral oophorectomy; has medically documented ovarian failure (with serum estradiol and follicle-stimulating hormone [FSH] levels within the institutional laboratory postmenopausal range and a negative serum or urine beta human chorionic gonadotropin [βHCG]); or is menopausal (age ≥50 years with amenorrhea for ≥6 months). For male patients who can father a child and are having intercourse with females of childbearing potential who are not using adequate contraception, willingness to use an effective method of contraception from the start of study therapy until ≥3 months after the last dose of cirmtuzumab and ≥3 months after the last dose of ibrutinib, whichever is later and to refrain from sperm donation from the start of study therapy until ≥3 months after administration of the final dose of either of the study drugs. Note: A male patient is considered able to father a child unless he has had a bilateral vasectomy with documented aspermia or a bilateral orchiectomy. In the judgment of the investigator, participation in the protocol offers an acceptable benefit-to-risk ratio when considering current disease status, medical condition, and the potential benefits and risks of alternative treatments for the patient's cancer. Willingness and ability of the patient to comply with scheduled visits, drug administration plan, protocol-specified laboratory tests, other study procedures, and study restrictions. Evidence of a personally signed informed consent indicating that the patient is aware of the neoplastic nature of the disease and has been informed of the procedures to be followed, the experimental nature of the therapy, alternatives, potential risks and discomforts, potential benefits, and other pertinent aspects of study participation. Exclusion Criteria: Known histological transformation to an aggressive lymphoma (ie, Richter transformation). Known central nervous system malignancy. Presence of another cancer with disease manifestations or therapy that could adversely affect subject safety or longevity, create the potential for drug-drug interactions, or compromise the interpretation of study results. Significant cardiovascular disease (eg, myocardial infarction, arterial thromboembolism, cerebrovascular thromboembolism) within 3 months prior to start of study therapy; angina requiring therapy; symptomatic peripheral vascular disease; New York Heart Association Class 3 or 4 congestive heart failure; or uncontrolled Grade ≥3 hypertension (diastolic blood pressure ≥100 mmHg or systolic blood pressure ≥160 mmHg) despite antihypertensive therapy. Significant screening ECG abnormalities, including unstable cardiac arrhythmia requiring medication, atrial fibrillation/flutter, left bundle branch block, 2nd-degree atrioventricular (AV) block type II, 3rd-degree AV block, or Grade ≥2 bradycardia. Gastrointestinal disease (eg, gastric or intestinal bypass surgery, pancreatic enzyme insufficiency, malabsorption syndrome, symptomatic inflammatory bowel disease, chronic diarrheal illness, bowel obstruction) that might interfere with drug absorption or with interpretation of gastrointestinal AEs. Contraindication for ibrutinib use because of bleeding diathesis. Evidence of an ongoing systemic bacterial, fungal, or viral infection (including upper respiratory tract infections) at the time of start of study therapy. Note: Patients with localized fungal infections of skin or nails are not precluded from participation. In patients with prior hematopoietic progenitor cell transplantation, evidence of ongoing graft-versus-host disease (GVHD). Pregnancy or breastfeeding. Major surgery within 4 weeks before the start of study therapy. Prior solid organ transplantation. Prior anti-ROR1 therapy within 12 weeks prior to the start of study therapy. Use of a moderate or strong inhibitor or inducer of cytochrome P450 (CYP) 3A4 within 7 days prior to the expected start of ibrutinib therapy. Concurrent participation in another therapeutic or imaging clinical trial. Any illness, medical condition, organ system dysfunction, or social situation, including mental illness or substance abuse, deemed by the investigator to be likely to interfere with a subject's ability to provide informed consent, adversely affect the subject's ability to cooperate and participate in the study, or compromise the interpretation of study results.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Sequential Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Part 1<br>Cirmtuzumab followed by Cirmtuzumab plus ibrutinib | Drug: Cirmtuzumab (2-16 kg/mg) plus Ibrutinib<br>* Participants will receive escalating doses of cirmtuzumab (2-16 mg/kg) administered IV every 2 weeks for 5 administrations and then every 4 weeks thereafter, plus ibrutinib (420 or 560 mg) orally once daily, starting at week 4.<br>* Other names: Imbruvica;Drug: Cirmtuzumab (300mg) plus Ibrutinib<br>* Participants will receive cirmtuzumab (300 mg) administered IV every 2 weeks for 5 administrations and then every 4 weeks thereafter, plus ibrutinib (420 mg) orally once daily.<br>* Other names: Imbruvica;Drug: Cirmtuzumab (600 mg) plus ibrutinib<br>* Participants will receive cirmtuzumab (600 mg) administered IV every 2 weeks for 5 administrations and then every 4 weeks thereafter, plus ibrutinib (420 mg) orally once daily.<br>* Other names: Imbruvica;|
| Experimental: Part 2<br>Cirmtuzumab plus ibrutinib | Drug: Cirmtuzumab (RDR) plus ibrutinib<br>* Participants will receive cirmtuzumab (600 mg) administered IV every 2 weeks for 3 administrations and then every 4 weeks thereafter, plus ibrutinib (420 or 560 mg) orally once daily<br>* Other names: Imbruvica;|
| Experimental: Part 3 - Arm A<br>Cirmtuzumab plus ibrutinib | Drug: Cirmtuzumab plus ibrutinib<br>* Arm A: Participants will receive cirmtuzumab (600 mg) administered IV every 2 weeks for 3 administrations and then every 4 weeks thereafter, plus ibrutinib (420 mg) orally once daily.<br>* Other names: Imbruvica;|
| Active Comparator: Part 3 - Arm B<br>Ibrutinib only | Drug: Ibrutinib alone<br>* Arm B: Participants will receive ibrutinib (420 mg) orally once daily<br>* Other names: Imbruvica;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Part 1:To determine the Recommended dosing regimen (RDR) of cirmtuzumab within the tested dose range in combination of ibrutinib |  | From first dose of study drug to completion of study drug treatment and have been followed for > 30 days | 
| Part 2: To determine the Recommended dosing regimen (RDR) of cirmtuzumab in combination with ibrutinib |  | From first dose of study drug to completion of study drug treatment and have been followed for > 30 days | 
| Parts 1-2: Treatment-emergent adverse events (TEAEs) as assessed by CTCAE v4.03 | Defined as type, frequency, severity, timing of onset, duration, and relationship to study drugs of any treatment-emergent adverse events (TEAEs); SAEs; or AEs leading to interruption, modification, or discontinuation of study treatment | From first dose of study drug to 30 days after the last dose of study drug or 72 weeks after accrual of the final subject | 
| Parts 1-3: To evaluate Complete Response Rate | Defined as the proportion of subjects that achieve CR for those with CLL/SLL; and the achievement of a CR for those with MCL or MZL | From randomization to end of follow up or 72 weeks after accrual of the final subject | 
| Parts 1-3: To evaluate Overall Response | Defined as achievement of complete response (CR), complete response with incomplete blood count recovery (CRi), partial response (PR), or partial response with lymphocytosis (PR-L) for those with CLL/SLL; and the achievement of a CR or PR for those with MCL or MZL. | From randomization to end of follow up or 72 weeks after accrual of the final subject | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Part 3: Treatment-emergent adverse events (TEAEs) as assessed by CTCAE v4.03 | Defined as type, frequency, severity, timing of onset, duration, and relationship to study drugs of any treatment-emergent adverse events (TEAEs); laboratory abnormalities; vital sign abnormalities; adverse electrocardiogram (ECG) findings; SAEs; or AEs leading to interruption, modification, or discontinuation of study treatment | From first dose of study drug to 30 days after the last dose of study drug or 72 weeks after accrual of the final subject | 
| Parts 1-2: Area under the serum concentration-time curve [AUC] | To determine the pharmacokinetic profile of cirmtuzumab alone and in combination with ibrutinib | From first dose of study drug to 30 days after the last dose of study drug | 
| Parts 1-3: Changes in ROR1 cell surface expression and receptor occupancy | To determine the effects of cirmtuzumab and cirmtuzumab + ibrutinib on exploratory biomarkers | From first dose of study drug to completion of study drug treatment and have been followed for > 12 weeks | 
| Parts 1-3: To evaluate the Immunogenicity | Immunogenicity as measured by neutralizing anti-drug antibodies (NAbs) to CIRM over time in seronegative and seropositive participants (based on central lab test) | From randomization to 30 days after the last dose of study drug or 72 weeks after accrual of the final subject | 
| Parts 1-3:To evaluate Overall Response (OR) | Defined as achievement of complete response (CR), complete response with incomplete blood count recovery (CRi), partial response (PR), or partial response with lymphocytosis (PR-L) for those with CLL/SLL; and the achievement of a CR or PR for those with MCL or MZL | From randomization to 30 days after the last dose of study drug or 72 weeks after accrual of the final subject | 
| Parts 1, 2, 3:To evaluate Complete Response (CR) | Defined as achievement of CR or CRi for those with CLL/SLL; and the achievement of a CR for those with MCL or MZL | From randomization to 30 days after the last dose of study drug or 72 weeks after accrual of the final subject | 
| Parts 1-3:To evaluate percent change in tumor dimensions | Defined as the best (most negative) percent change from baseline in the sum of the products of the diameters (SPD) of index lesions | From randomization to end of follow up or 72 weeks after accrual of the final subject | 
| Parts 1-3: To evaluate Time to Response (TTR) | Defined as the interval from the start of study therapy to the first documentation of an objective response | From randomization to end of follow up or 72 weeks after accrual of the final subject | 
| Parts 1-3:To evaluate Duration of Response (DOR) | Defined as the interval from the first documentation of objective response to the earlier of the first documentation of disease progression or death from any cause | From randomization to end of follow up or 72 weeks after accrual of the final subject | 
| Parts 1-3: To evaluate Progression-free Survival (PFS) | Defined as the interval from the start of study therapy to the earlier of the first documentation of disease progression or death from any cause | From randomization to end of follow up or 72 weeks after accrual of the final subject | 
| Parts 1-3: To evaluate Time to Progression (TTP) | Defined as the time from the start of study therapy until objective tumor progression; TTP does not include deaths | From randomization to end of follow up or 72 weeks after accrual of the final subject | 
| Parts 1-3: To evaluate Time to Treatment Failure (TTF) | Defined as the interval from start of study therapy to the earliest of the first documentation of disease progression, the permanent cessation of study drug due to an AE, or death from any cause | From randomization to end of follow up or 72 weeks after accrual of the final subject | 
| Parts 1-3:To evaluate Time to Next Treatment (TNT) | Defined as the interval from start of study therapy to the earliest of the start of a new regimen for CLL/SLL, MCL or MZL due to study treatment failure | From randomization to end of follow up or 72 weeks after accrual of the final subject | 
| Parts 1-3: To evaluate Overall Survival (OS) | Defined as the interval from the start of study therapy to death from any cause | From randomization to end of follow up or 72 weeks after accrual of the final subject | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Chronic lymphocytic leukemia, Small lymphocytic lymphoma, Mantle cell lymphoma, Receptor Tyrosine Kinase-like Orphan Receptor 1 (ROR1), Bruton Tyrosine Kinase (BTK), Ibrutinib, Marginal zone lymphoma