Clinical Study on Endometrial Receptivity

Study Overview
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Brief Summary
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to explore the differential expression of miRNA in the implantation window of patients with endometriosis and the time of progesterone and route of administration on planting window

Official Title
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Clinical Study on the Impact of Route of Administration of Progesterone and Endometriosis on Endometrial Receptivity

Conditions
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Endometrial Receptivity;RNA; Progesterone

Intervention / Treatment
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* Drug: Progesterone


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: The endometriosis group treatment group: Previous laparoscopy or laparotomy confirmed endometriosis;Regular menstruation, no rule vaginal bleeding;Ovarian reserve function is normal. control group: Laparoscopic bilateral salpingectomy was performed due to ectopic pregnancy, benign ovarian changes and other reasons, with the exception of endometriosis during the operation.Regular menstruation, no rule vaginal bleeding;Ovarian reserve function is normal progesterone group Women with hypothalamic amenorrhea or premature ovarian failure;Ages 18-40 Exclusion Criteria: Patients with medical complications

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: endometriosis<br>tissue biopsy from patients (n=10) with endometriosis | |
| No Intervention: without endometriosis<br>tissue biopsy from patients (n=10) without endometriosis | |
| Experimental: Intramuscular progesterone<br>Intramuscular progestin(20mg) | Drug: Progesterone<br>* Different routes of administration of progesterone; Whether there is endometriosis<br>|
| Experimental: vaginal progesterone<br>vaginal progestin (90mg) | Drug: Progesterone<br>* Different routes of administration of progesterone; Whether there is endometriosis<br>|
| Experimental: oral progesterone<br>oral progestin(40mg) | Drug: Progesterone<br>* Different routes of administration of progesterone; Whether there is endometriosis<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| endometrial receptivity measured by pathology | 35 samples will be measured. | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| endometrial receptivity measured by immunohisochemistry | 35 samples will be measured | 3 months | 
| endometrial receptivity measured by Ribose Nucleic Acid （RNA） | 35 samples will be measured | 3 months | 
| endometrial receptivity measured by scanning electron microscope | 35 samples will be measured | 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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endometrial receptivity, RNA, progesterone