Comparison of Different Materials Contribution to Implants Stability

Study Overview
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Brief Summary
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The investigators will use two types of material(PRF-Xenograft) in the buccal gap after immediate dental implant placement. The study design has three groups PRF, graft, and control group. The patients will randomly be assigned to groups by envelop method. The resonance frequency analysis device(Osstell) will be used to measure primary and secondary stabilization. Then the investigators will evaluate each materials' contribution to stability. Pre-op and 9th month Post-op CBCTs will evaluate about bone loss in mesial-distal and horizontal dimensions.

Official Title
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Comparison of Different Materials Contribution to Immediate Implants Stability With Resonance Frequency Analysis

Conditions
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Dental Implant Failure Nos

Intervention / Treatment
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* Other: platelet-rich fibrin placement
* Other: xenogenic graft placement
* Other: no extra material
* Procedure: tooth extraction
* Procedure: immediate implant placement
* Other: collagen membran placement
* Procedure: raising flap


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: medically healthy, only one maxillary aesthetic region(incisors or premolars) tooth which has two adjacent teeth is indicated for extraction. intact buccal socket walls the gap between buccal socket wall to implant sholder at least 2 mm. Exclusion Criteria: relevant tooth has more than one root, smoking, alcohol abuse, pregnancy, immune-suppressive patients, any systemic disease.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: PRF Group<br>PRF is will be used in immediate dental implant placement. | Other: platelet-rich fibrin placement<br>* filling the buccal gap with platelet-rich fibrin after immediate dental implant placement<br>Procedure: tooth extraction<br>* extraction of tooth which is unrestorable<br>Procedure: immediate implant placement<br>* putting dental implant into a socket which has been prepared with compatible drills<br>Other: collagen membran placement<br>* placing collagen membran on extraction socket after dental implant placement to cover all<br>Procedure: raising flap<br>* raising the buccal flap with two vertical incision to cover extraction socket for primary closure<br>|
| Experimental: Graft Group<br>The xenogenic graft is will be used in immediate dental implant placement. | Other: xenogenic graft placement<br>* filling the buccal gap with xenogenic graft after immediate dental implant placement<br>Procedure: tooth extraction<br>* extraction of tooth which is unrestorable<br>Procedure: immediate implant placement<br>* putting dental implant into a socket which has been prepared with compatible drills<br>Other: collagen membran placement<br>* placing collagen membran on extraction socket after dental implant placement to cover all<br>Procedure: raising flap<br>* raising the buccal flap with two vertical incision to cover extraction socket for primary closure<br>|
| Experimental: Control Group<br>No extra material is will be used in immediate dental implant placement. | Other: no extra material<br>* filling the buccal gap with no material after immediate dental implant placement<br>Procedure: tooth extraction<br>* extraction of tooth which is unrestorable<br>Procedure: immediate implant placement<br>* putting dental implant into a socket which has been prepared with compatible drills<br>Other: collagen membran placement<br>* placing collagen membran on extraction socket after dental implant placement to cover all<br>Procedure: raising flap<br>* raising the buccal flap with two vertical incision to cover extraction socket for primary closure<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Primer Stabilization-Resonance Frequency Analysis | initial measurement after placement by Osstell device | at 0 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Seconder Stabilization-Resonance Frequency Analysis | secondary measurement after placement by Osstell device | 120th day | 
| Mesial-Distal and Horizontal Bone Loss | The alveolar bone loss between first day to 9th month | 9th month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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immediate implant placement