linjc16/ctgov huggingface dataset:
The Identification of Novel Prognostic Markers in Melanoma

Study Overview
=================
Brief Summary
-----------------
The purpose of this project is to analyze tumour tissue from a group of subjects with malignant melanoma, who have been treated at the Royal Marsden Hospital.

Detailed Description
-----------------
Background - The Royal Marsden Hospital and the Institute of Cancer Research constitute the largest comprehensive cancer centre in Europe. In addition to an in-house drug development program, phase I - phase III clinical trials of novel anti-cancer agents are hosted. In order to investigate the optimal use of novel molecularly targeted agents, access to clinical tumour samples is needed in order to determine which particular cancer type expresses a molecular signature that may indicate potential therapeutic utility. Understanding such signatures should accelerate the registration of new drugs for routine cancer therapy; offering the potential of selecting those patients with tumour types most likely to benefit from therapy. Furthermore, new insights into disease biology may be gained. Main research question/ objective - Are there features of primary melanoma or lymph node metastases that predict subsequent clinical outcome better than existing markers?

Official Title
-----------------
Novel Prognostic Markers in Melanoma: a Protocol for the Analysis of Paraffin-embedded Tumour Samples

Conditions
-----------------
Malignant Melanoma

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosis of melanoma Adequate paraffin-embedded material available for analysis. Adequate clinical follow-up information Written informed consent where applicable Exclusion Criteria: Inadequate paraffin-embedded material available Inadequate clinical follow-up information.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Malignant melanoma tumour tissue<br> | |
| Benign pigmented lesions & other skin cancers<br>Normal skin, benign melanocytic tumours, and skin cancers from lineages other than melanocytic, to be used as negative controls | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Given that the nature of the research is qualitative, there is no primary outcome measure. |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Melanoma, Novel Prognostic Markers
Surgical Outcome and Predictors of Overall Survival of Stage I-III Appendiceal Adenocarcinoma

Study Overview
=================
Brief Summary
-----------------
A few studies investigated the predictors of overall survival in appendiceal adenocarcinoma. A SEER database analysis of 1404 patients with appendiceal adenocarcinoma found that older age, T4 tumors, N1-2 stage, poorly differentiated carcinoma, and distant metastasis were significantly predictive of poorer survival. Another small single-center study including 49 appendiceal cancer patients reported female gender and low-grade adenocarcinoma to be associated with increased overall survival. However, these previous analyses did not take into account some important prognosticators of survival such as patients' comorbidities and functional status, pathologic parameters such as lymphovascular invasion, and adjuvant systemic treatment. Therefore, we used the National Cancer Database (NCDB) to conduct a comprehensive analysis of the predictors of overall survival after surgical treatment of stage I-III appendiceal adenocarcinoma.

Official Title
-----------------
Surgical Outcome and Predictors of Overall Survival of Stage I-III Appendiceal Adenocarcinoma; a National Cancer Database Analysis

Conditions
-----------------
Appendiceal Cancer

Intervention / Treatment
-----------------
* Procedure: Partial colecctomy
* Procedure: Hemicolectomy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients with non-metastatic appendiceal adenocarcinoma who underwent surgical resection Exclusion Criteria: Patients with other pathologic types of appendiceal cancer Patients with clinical stage IV or unknown stage Patients who did not undergo surgery, underwent local excision, or had unknown/non-specified surgery
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Partial colectomy<br>Patients with appendiceal cancer who underwent segmental resection of appendiceal adenocarcinoma | Procedure: Partial colecctomy<br>* Segmental resection of appendiceal adenocarcinoma including terminal ileum and cecum<br>|
| Hemicolectomy<br>Patients with appendiceal cancer who underwent formal right hemicolectomy of appendiceal adenocarcinoma | Procedure: Hemicolectomy<br>* Formal right hemicolectomy including terminal ileum, cecum, and ascending colon<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overall survival | Percent of patients who were alive at five years of follow-up | 60 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Positive resection margins | the rate of surgical margins infiltrated by malignancy | Immediate postoperative |
Effectiveness of a Cancer Center Based Physical Activity Intervention

Study Overview
=================
Brief Summary
-----------------
Purpose: Examine the effectiveness of cancer center-based physical activity counseling on physical activity rates and quality of life in breast cancer survivors. Hypothesis: Participants in the intervention group will indicate greater step counts and quality of life at the end of the intervention compared to the control group

Official Title
-----------------
Effectiveness of a Cancer Center Based Physical Activity Intervention

Conditions
-----------------
Breast Cancer, Quality of Life, Physical Activity

Intervention / Treatment
-----------------
* Behavioral: Physical activity counseling


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosis of breast cancer within the last 5 years Over the age of 18 years female Exclusion Criteria: Non-ambulatory Poor cognitive function Contraindications for exercise as determined by the PAR-Q

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Physical activity counseling<br>Group receives face-to-face physical activity counseling. | Behavioral: Physical activity counseling<br>* 20-30 minutes of face-to-face physical activity counseling using motivational interviewing followed by 3 20 minute telephone counseling sessions.<br>|
| Active Comparator: Manual<br>Group receives physical activity manual. | Behavioral: Physical activity counseling<br>* 20-30 minutes of face-to-face physical activity counseling using motivational interviewing followed by 3 20 minute telephone counseling sessions.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Effectiveness of a cancer center based physical activity intervention for increasing physical activity in breast cancer survivors. | The primary outcome is to examine the effectiveness of a cancer center based physical activity intervention on increasing physical activity as measured by step counts on a pedometer. | 8 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Effectiveness of a cancer center based physical activity counseling intervention on increasing quality of life in breast cancer survivors. | The secondary outcome is to examine the effectiveness of a cancer center based physical activity counseling intervention on improving quality of life in breast cancer survivors. | 8 weeks |
Study of Sublingual Versus Oral Misoprostol Administration Following Mifepristone 200 mg for Abortion up to 63 Days Gestation

Study Overview
=================
Brief Summary
-----------------
This open-label, randomized study is being conducted to determine whether a dose of 400 mcg of sublingual misoprostol (i.e., under the tongue) taken 24 hours following administration of mifepristone 200 mg is effective and acceptable at inducing an abortion compared with misoprostol taken orally. The goal of this study is to provide answers to the following four questions: Is a regimen of medical abortion with mifepristone using sublingual misoprostol at least as effective as using oral misoprostol up to 63 days since the last menstrual period (LMP)? Are the side effects with sublingual use tolerable for women? Is sublingual administration of misoprostol acceptable to women? Is one of the regimens (sublingual or oral) superior in terms of efficacy, safety (side-effects) or acceptability?

Official Title
-----------------
A Randomized Study of Sublingual Versus Oral Misoprostol Administration Following Mifepristone 200 mg for Abortion up to 63 Days Gestation

Conditions
-----------------
Induced Abortion

Intervention / Treatment
-----------------
* Drug: Mifepristone, misoprostol


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Women presenting for medical abortion who consent to participate Possibility of final gestational age of less than or equal to 63 days General good health Willing to provide contact information for purposes of follow-up Exclusion Criteria: Conditions which contraindicate the use of mifepristone or misoprostol Women presenting for medical abortion who do not consent to participate
Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Sublingual Misoprostol<br>400 mcg of sublingual misoprostol | Drug: Mifepristone, misoprostol<br> <br> |
| Active Comparator: Oral Misoprostol<br>Misoprostol administered orally | Drug: Mifepristone, misoprostol<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Need for surgical completion for incomplete abortions or ongoing viable pregnancies at follow up visit Study day 15. |  | 2 weeks after mifepristone administration | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Side effects |  | 48 hours | 
| Acceptability for women |  | 2 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Medical abortion, mifepristone, misoprostol
Laparotomy Closure Techniques: do Surgeons Follow the Latest Guidelines? Results of a Questionnaire.

Study Overview
=================
Brief Summary
-----------------
Incisional hernias after laparotomy are associated with significant morbidity and increased costs. Research is focused on development of new techniques to prevent incisional hernia. Little is known about application of this evidence in daily practice. Therefore, a survey was performed among Dutch surgeons.

Detailed Description
-----------------
Incisional hernias after laparotomy are associated with significant morbidity and increased costs. Research is focused on development of new techniques to prevent incisional hernia. Little is known about application of this evidence in daily practice. Therefore, a survey was performed among Dutch surgeons. All members of the Dutch Surgical Society were invited to participate in a 24-question online survey on techniques and materials used for abdominal wall closure after midline laparotomy. Subgroup analysis based on surgical subspecialty, hospital and experience was performed.

Official Title
-----------------
Laparotomy Closure Techniques: do Surgeons Follow the Latest Guidelines? Results of a Questionnaire.

Conditions
-----------------
Incisional Hernia, Laparotomy Closure Technique

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: surgeon in the Netherlands Exclusion Criteria: not practicing surgery not practicing in the Netherlands
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| opinions on and current technique used for laparotomy closure | multiple choice questions | July till August 2016 at survey completion; snapshot measurement | 
| knowledge of incisional hernia development | multiple choice questions | July till August 2016 at survey completion; ; snapshot measurement | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
incisional hernia, prevention, laparotomy closure, quality improvement, survey, guideline
The Effect of Guided Imagery on the Third Stage of Labor

Study Overview
=================
Brief Summary
-----------------
The purpose of this study was to evaluate the effect of guided imagery on the third stage of labor. Blood loss from hemorrhage during childbirth, most commonly due to uterine atony, is one of the leading causes of maternal mortality in the United States and the leading cause of maternal death worldwide. The hypothesis was that the use of physiologic guided imagery would reduce the amount of bleeding during the third stage of labor.

Official Title
-----------------
The Effect of Guided Imagery on the Third Stage of Labor

Conditions
-----------------
Third Stage of Labor, Bleeding, Guided Imagery, Childbirth

Intervention / Treatment
-----------------
* Behavioral: Guided imagery


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 18 years of age or older but less than 35 years English as her primary language fetus in a cephalic presentation singleton pregnancy 36 to 38 estimated gestational weeks no contraindications to vaginal delivery maternal weight less than 200 pounds prior to pregnancy Exclusion Criteria: more than four previous children a history of postpartum hemorrhage bleeding disorder seizure disorder polyhydramnios diabetes (including gestational) hypertension cardiac disease uterine fibroids anemia (hematocrit less than 30) intrauterine fetal demise or tobacco use

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 34 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Guided imagery<br>The experimental group received a relaxation focused guided imagery intervention to use through the remainder of pregnancy plus a physiologic guided imagery intervention during the third stage of labor. These interventions were scripted and prerecorded on CDs. | Behavioral: Guided imagery<br>* A relaxation focused guided imagery intervention was used through the remainder of pregnancy plus a physiologic guided imagery intervention was used during the third stage of labor.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood Loss |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Length of third stage of labor |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
third stage of labor, bleeding, guided imagery, childbirth
Rewarding Feedback in Motor Learning and Rehabilitation

Study Overview
=================
Brief Summary
-----------------
The effect of rewarding vs. non-rewarding feedback on acquisition of a motor skill is investigated in a single blinded parallel group design. Reward consists of performance dependent monetary reward, or of knowledge of performance in selected (above average) trials. The investigators hypothesize improved motor skill learning and higher involvement of the dopaminsrgic system under rewarding vs. non-rewarding conditions.

Official Title
-----------------
Die Auswirkung Von Dopaminergen Belohnungsreizen Auf Das Lernen Einer Motorischen Fertikgeit Bei Gesunden Probanden Effects of Dopaminergic Reward on Motor Skill Learning in Healthy Subjects

Conditions
-----------------
Motor Performance, Motor Learning

Intervention / Treatment
-----------------
* Behavioral: Feedback about good performance
* Behavioral: Feedback about good performance + money
* Behavioral: Feedback about average performance


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: neurologically healthy right handed Exclusion Criteria: Contraindications against magnetic resonance imaging pregnancy

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 35 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Intrinsic reward<br>Feedback about good performance | Behavioral: Feedback about good performance<br> <br> |
| Experimental: Intrinsic and extrinsic reward<br>Feedback about good performance + money | Behavioral: Feedback about good performance + money<br> <br> |
| Experimental: Intrinsic reward (average performance)<br>Feedback about random selection of trials | Behavioral: Feedback about average performance<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Motor skill learning using an arc pointing task | temporal and spacial precision in an arc pointing task will be assessed using 5 different movement speeds during the above mentioned time periods before and after a specific motor learning programm. Learning will be assessed as change from pre-training to post training | about 10 minutes pre-training, about 10 min post training, about 24h post training |
The Use of Gastrografin in Chronic Radiation Enteropathy With Small Bowel Obstruction

Study Overview
=================
Brief Summary
-----------------
Chronic radiation enteropathy (CRE) is a major issue for long-term cancer survivors. The aim of this study was to clarify the diagnostic and therapeutic effect of the Gastrografin (GG) challenge for patients with CRE induced small bowel obstruction SBO.

Official Title
-----------------
The Use of Gastrografin in Chronic Radiation Enteropathy With Small Bowel Obstruction：A Retrospective Study

Conditions
-----------------
CRE-induced SBO

Intervention / Treatment
-----------------
* Drug: Gastrografin


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: with a first diagnosis of CRE combined with SBO and ASBO that was determined by clinical history, computed tomography (CT) manifestation, and conﬁrmed by intraoperative and histologic ﬁndings. radiation therapy completed at least 6 months before enrolment. Exclusion Criteria: a colostomy or ileostomy; large bowel obstruction; with a known history of either allergy or hypersensitivity to iodinated contrast agents; with signs of strangulation; metastatic disease; obstruction within 4 weeks after a recent operation or serious comorbidity.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: CRE-induced SBO<br>Patients with CRE-induced SBO received GG challenge. | Drug: Gastrografin<br>* Patients with CRE-induced SBO or ASBO both received GG challenge.<br>|
| Active Comparator: ASBO<br>Patients with adhesive SBO (ASBO) received GG challenge. | Drug: Gastrografin<br>* Patients with CRE-induced SBO or ASBO both received GG challenge.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The rate of successful conservative treatment | The rate of patients who need for operative intervention within 48 hours of randomization. | 5 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The time to resolution | The time to resolution of ASIO (flatus and bowel motion). | 2 weeks | 
| The length of hospital stays | The length of hospital stays (in hours, calculated from the hospital admission to resolution of intestinal obstruction). | 2 weeks |