Affective Processing in Depression and Epilepsy

Study Overview
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Brief Summary
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The goal of this study is to determine whether there are unique markers on neuroimaging that are associated with depression in epilepsy.

Detailed Description
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Symptoms of depression is commonly seen in patients with epilepsy. There are similarities and differences between depressive symptoms in epilepsy when compared with primary depression. Through the use of fMRI (Functional MRI), we hope to determine whether there are unique markers on neuroimaging that are associated with depression in epilepsy.

Official Title
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Affective Processing in Depression and Epilepsy; An fMRI Study

Conditions
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Epilepsy, Depression, Healthy

Intervention / Treatment
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* Other: fMRI
* Other: Hamilton Depression Rating Scale
* Other: Beck's Depressive Inventory
* Other: Interictal Dysphoric Disorder Inventory (IDDI)


Participation Criteria
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Eligibility Criteria
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For Control Group Inclusion Criteria: Healthy adults of 18 years of age or older. Exclusion Criteria: Subject has no history of affective disorders Subject scores higher than 5 on Hamilton Depression Rating Scale Subject with prior primary diagnosis of any psychotic disorder, bipolar disorder, anxiety disorder, or any other serious medical or neurological disorder Subject is pregnant Subject is unable to undergo a MRI Epilepsy Only Group Inclusion Criteria: Subject is at least 18 years of age Subject has confirmed temporal lobe epilepsy (TLE) Exclusion Criteria: Subject has a history of depression Subject scores higher then 5 on Hamilton Depression Rating Scale Subject with prior primary diagnosis of any psychotic disorder, bipolar disorder, anxiety disorder, or any other serious medical or neurological disorder Subject is pregnant Subject is unable to undergo a MRI Depression Only Group Inclusion Criteria: Subject is at least 18 years of age Subject scores between 12 and 18 on Hamilton Depression Rating Scale Exclusion Criteria: Subject scores higher than 18 on Hamilton Depression Rating Scale Subject is currently being medicated for depression Subject has history of major depression or dysthymia Subject with prior primary diagnosis of any psychotic disorder, bipolar disorder, anxiety disorder, or any other serious medical or neurological disorder Subject is pregnant Subject is unable to undergo a MRI Depression and Epilepsy Group Inclusion Criteria: Subject has confirmed temporal lobe epilepsy (TLE) Subject scores between 12 and 18 on Hamilton Depression Rating Scale Exclusion Criteria: Subject has history of major depression or dysthymia Subject is currently on medication for depression Subject with prior primary diagnosis of any psychotic disorder, bipolar disorder, anxiety disorder, or any other serious medical or neurological disorder Subject is pregnant Subject is unable to undergo a MRI

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: fMRI|Subjects will undergo MRI scanning to gather data about cognetive functions.|
|Other: Hamilton Depression Rating Scale|Investigator will evalute the subject during a one on one interview for depression using the Hamilton Depression Rating Scale.|
|Other: Beck's Depressive Inventory|Subjects will complete self assessment to evaluate their level of depression.|
|Other: Interictal Dysphoric Disorder Inventory (IDDI)|Subject will complete self assessment to determine if there have been any changes in mood, emotions and or feelings from time to time.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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fMRI, Epilepsy, Depression, Neurology, Healthy Controls