Pilot Study of Functional and Morphometric Brain Abnormalities Related to Adolescent Idiopathic Scoliosis (MOR-FO-SIA)

Study Overview
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Brief Summary
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Adolescent idiopathic scoliosis (AIS) is a complex deformity with different curves. These different curves may be distinguished by different physiopathologic mechanisms. Without fully convincing model of the emergence and development of AIS, their multifactorial nature seems evident. Several pathophysiological theories involving the central nervous system have been proposed: the AIS would be associated with disturbances of proprioceptive or sensory perception, and/or with integration of this information. This would result in an abnormal body image, responsible for sensorimotor asymmetry that may promote or cause the deformation. The Main aim of this study is to find cortical and subcortical morphometric differences in the most common population of AIS (right thoracic AIS) compared to healthy adolescent control girls. Secondary Objectives are to study the cerebral white matter of the same groups (fractional anisotropy in the main white matter tracts), and activation of sensorimotor neural networks (fMRI activation and functional brain connectivity). Abnormalities of the studied parameters may be used as biomarkers for AIS diagnosis and classification.

Official Title
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Pilot Study of Functional and Morphometric Brain Abnormalities Related to Adolescent Idiopathic Scoliosis (MOR-FO-SIA)

Conditions
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Adolescent Idiopathic Scoliosis

Intervention / Treatment
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* Device: MRI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: female between 14 and 16 years old normal neurological examination right handed informed consent informed consent form signed by a parent or a holder of parental authority affiliated to medical insurance negative urine pregnancy test For patients (A-STD) : right thoracic scoliosis with a Cobb angle between 20 and 40° For healthy volunteers (A-N) : no clinical scoliosis Exclusion Criteria: pregnant or lactating woman antecedents of cranial trauma or cranial intervention, of migraine, of spinal trauma, of scoliosis intervention no idiopathic scoliosis contraindications to MRI patient with a legal protection measure

Ages Eligible for Study
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Minimum Age: 14 Years
Maximum Age: 16 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: patients<br>2 groups with MRI : - 8 right thoracic AIS participants (Cobb angle between 20 and 40°) | Device: MRI<br>* MRI<br>|
| Experimental: controls subjects<br>- 8 healthy controls (no clinical scoliosis) | Device: MRI<br>* MRI<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Variation in regional cortical and subcortical volume, as measured by MRI |  | One day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Variation in fractional anisotropy in the main white matter tracts, as measured by MRI |  | one day | 
| Variation in activation of sensorimotor neural networks, as measured by MRI |  | one day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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scoliosis, MRI (Magnetic Resonance Imaging)