linjc16/ctgov huggingface dataset:
Retrospective Study in Sarcoma Patients

Study Overview
=================
Brief Summary
-----------------
The objectives of this trial is to evaluate efficacy and safety of treatment with Trabectedin in a large cohort of German patients with soft tissue and bone sarcomas.

Official Title
-----------------
Retrospective Study to Evaluate Efficacy and Safety of Trabectedin (Yondelis®) in Sarcoma Patients

Conditions
-----------------
Sarcoma of Bone, Sarcoma of Soft Tissue

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with histologically confirmed soft tissue or bone sarcomas treated with at least one cycle of Trabectedin in any line of therapy. Age ≥18years at start of therapy with Trabectedin Informed Consent Patients already deceased may be included when the treating physician is able to determine the presumptive consent Exclusion Criteria: No follow-up data available

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| - Progression free survival (PFS) |  | At the time of every treatment documentation up to the end of treatment, approximately 2 years | 
| - Overall survival (OS) |  | At the time of every treatment documentation up to the end of treatment, approximately 2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| CTCAE (Common Terminology Criteria for Adverse Events) 4.03 | Safety Evaluation according to toxitiy | At the time of every treatment documentation up to the end of treatment, approximately 2 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Drug therapy, Treatment outcome, Adult
Cervical Stairstep and Effects on Range of Motion (ROM)

Study Overview
=================
Brief Summary
-----------------
Observe the effects of Cervical Stairstep on Cervical Spine Range of Motion

Detailed Description
-----------------
The cervical spine can be affected in a number of ways due to its vulnerability to injury. These injuries can result from poor posture, sports or occupation and can lead to degenerative changes. Cervical range of motion (ROM) is also affected by these injuries. When active ROM is restricted, the injury is of muscular origin. Pain with passive ROM indicates ligamentous injury whereas restricted passive ROM indicates blockage within bone or soft tissue. The normal range of motion in the cervical spine is 80-90 degrees flexion, 70 degrees extension, 20-45 degrees lateral flexion and 90 degrees of rotation. A common mechanism of cervical spine injury is axial loading. Axial loading can create a buckling effect within the cervical spine and decrease its ability to move normally, creating a limited ROM.

Official Title
-----------------
The Effects of Cervical Stairstep on Cervical Range of Motion

Conditions
-----------------
Range of Motion, Articular

Intervention / Treatment
-----------------
* Procedure: Cervical Stairstep


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: students and faculty between ages 18 and 50 Exclusion Criteria: current neck pain (as measured by the Neck Disability Index (NDI) and utilizing Jackson's and maximal foraminal compression tests to assess for radiating symptoms) severe recent head trauma acute exacerbations within the past 3 months known cervical disc problems surgical fusions within the cervical spine highly acute symptoms a positive valsalva test seizure disorder analgesics muscle relaxants medications with effects on the musculoskeletal system chiropractic manipulation within 48 hours of the study Other exclusions can be made based on investigator judgment

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Experimental<br>Cervical low force mobilization procedure. | Procedure: Cervical Stairstep<br>* Cervical low force mobilization procedure.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cervical Range of Motion |  | Pre and post treatment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Neck Disability Index |  | pre and post treatment |
Tilt Cardiopulmonary Resuscitation With a Feedback Device

Study Overview
=================
Brief Summary
-----------------
According to the European Resuscitation Council (ERC) Guidelines for patient to a depth of approximately 5-6 cm on a firm and flat surface when possible. However, Cardiopulmonary resuscitation (CPR) performers may need to continue the chest Resuscitation 2010, CPR performers should compress the sternum of a compression in an oblique direction, such as in elevators. For a pregnant patient in cardiac arrest, the 2010 ERC Guidelines recommend that the performer place the patient in a left-lateral tilt of 15 - 30° using a firm wedge to support the pelvis and thorax because the pregnant uterus can compress the inferior vena cava. We hypothesized Smartphone based chest compression feedback app would improves quality of CPR in an angulated surface.

Conditions
-----------------
Cardiopulmonary Resuscitation, Basic Cardiac Life Support

Intervention / Treatment
-----------------
* Device: Audiovisual feedback from smartphone based app


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy person > 18 years old Basic life support educated person Exclusion Criteria: Cardiovascular disease Musculoskeletal disease Psychiatric disease Pregnant > 65 years old

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Without feedback<br>Participants compress the chest of the manikin without smartphone based feedback app. | |
| Experimental: With feedback<br>Participants compress the chest of the manikin with a smartphone based feedback app. | Device: Audiovisual feedback from smartphone based app<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Chest compression depth | To measure chest compression depth during 2 minutes | within the first 30 days after the end of recording | 
| Chest compression rate | To measure the chest compression rate during 2 minutes | within the first 30 days after the end of recording | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Accurate chest compression | To measure the percentage of accurate chest compressions (i.e. correct depth, hand position, and recoil) of total chest compressions during 2 minutes | within the first 30 days after the end of recording | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Chest, Compression
Qualitative Pain Measurement at Patients With Degenerative Low Back Pain

Study Overview
=================
Brief Summary
-----------------
The purpose of the study is: to measure sensitization of the nociceptive system at patients with low back pain in order to carry out a necessary surgical procedure to examine a possible association between low back pain and degenerative changes to analyse if low back pain is related to the clinical result 6 months after surgery to set up a model for pre-operative measurement of pain.

Official Title
-----------------
Qualitative Pain Measurement and Sensitization at Patients With Degenerative Low Back Pain With Indication for Lumbar Intervertebral Disc

Conditions
-----------------
Degeneration of Lumbar Intervertebral Disc

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients who are going to be treated surgically for spondylitis ability to understand Danish in order to filling in a questionnaire a written signed statement of consent Exclusion Criteria: removal of implants diabetic neuropathy or another neuropathic disease neurological diseases unability to read or understand Danish

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Pre-operative pain measurement<br>Patients with low back pain | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain measured at lumbar area, hip and ankle by an algometer | On basis of the extended examinations of low back pain, we expect to achieve a better knowledge to measure pain at this category of patients before a possible surgical procedure. | 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Pain, Sensitization, Spondylitis
Infliximab and Methotrexate in Ankylosing Spondylitis

Study Overview
=================
Brief Summary
-----------------
There is a great individual variability of pharmacokinetic of infliximab in patients treated for ankylosing spondylitis (AS). Moreover, some patients have a treatment with methotrexate (MTX), others have not. Thus, the aim of this study is to assess the effect of MTX on the pharmacokinetic properties of infliximab in 30 patients treated for AS, 15 with MTX, 15 without.

Official Title
-----------------
Effect of Methotrexate on the Relation Dose-effect of Infliximab in Ankylosing Spondylitis

Conditions
-----------------
Ankylosing Spondylitis

Intervention / Treatment
-----------------
* Drug: infliximab


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Ankylosing spondylitis Needing anti-TNF drugs Exclusion Criteria: Contra-indications to anti-TNF drugs

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Infliximab<br>Infliximab | Drug: infliximab<br> <br> |
| Experimental: Infliximab +methotrexate<br>Infliximab +methotrexate | Drug: infliximab<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pharmacokinetic properties of infliximab in AS patients with or without methotrexate |  | 16 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Individual pharmacokinetic modelisation of infliximab |  | 16 weeks |
Roy Adaptation Model in People With Type 1 Diabetes

Study Overview
=================
Brief Summary
-----------------
The study was conducted to determine the effect of Roy adaptation model-based education on disease compliance and metabolic control in adolescents with Type 1 diabetes.

Detailed Description
-----------------
This study was designed as a randomized controlled study. A total of 60 adolescents, training (n=30) and control (n=30) that meet the research criteria were divided by random method. Pre-training data of the groups were collected using the Sociodemographic Form, Diabetes Information Evaluation Form and Roy Adaptation Model Interview Form and HbA1c values were recorded. The training group was trained on the Roy Adaptation Model by a month break, in two sessions. After the training, the adolescents in the training group were given a curvature booklet based on the Roy Adaptation model. The control group was not intervened. After the training, the diabetes Information Assessment Form and the Roy Adaptation Model Discussion Form have applied to both groups again and the values of HbA1c were recorded.

Official Title
-----------------
Effect of Roy Adaptation Model on Metabolic Control in Adolescents With Type 1 Diabetes: Randomized Controlled Trial

Conditions
-----------------
Type 1 Diabetes, Adolescent

Intervention / Treatment
-----------------
* Other: Roy adaptation model-based nursing education


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: Having type 1 diabetes Must be between the ages of 11-18 volunteering for research Exclusion criteria Presence of mental disability To have received training on the content of the study

Ages Eligible for Study
-----------------
Minimum Age: 11 Years
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: education arm (n=30)<br>Roy adaptation model-based training was given to the training arm. | Other: Roy adaptation model-based nursing education<br> <br> |
| No Intervention: control arm (n=30)<br>Roy adaptation model-based training not given to the training arm | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| HbA1c values | change from baseline in HbA1c value at 3 months | 3 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diabetes Knowledge Level | change from baseline in diabetes knowledge level on the 32 points diabetes knowledge level form at month 2 | baseline and 2nd month |
Retrospective Observational Study on the Epidemiological Characteristics of Influenza Patients

Study Overview
=================
Brief Summary
-----------------
Seasonal influenza outbreaks contribute to the saturation of emergency services. Better knowledge of the epidemiology and clinical presentation of this pathology would optimize the organization of emergency reception services and provide better care for patients, disseminate educational elements to the population more appropriate as well as optimal recommendations for health professionals.

Official Title
-----------------
Retrospective Observational Study on the Epidemiological Characteristics of Influenza Patients Who Consulted in the Emergency Services of the University Hospitals of Strasbourg From September 2018 to March 2019

Conditions
-----------------
Influenza

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: Major subject ((≥18 years old) Subject who consulted the Emergency Department of the Adult Emergencies of the Strasbourg University Hospitals between September 2018 and March 2019 Subject for which the flu smear is positive Subject not expressing opposition to the use of his data for research purposes Exclusion criteria: Subject having expressed his opposition to participating in the study Subject for which the flu smear is negative Subject under the protection of justice Subject under guardianship or curators

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Retrospectively study of the epidemiological characteristics of influenza patients consulted at the Adult Emergencies of Strasbourg University Hospitals |  | Files analyzed retrospectily from September 1st, 2018 to March 30, 2019 will be examined | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Influenza, Grippe, Emergency Services, Influenza, Human
Acute Phase Proteins as Early Markers in Sepsis

Study Overview
=================
Brief Summary
-----------------
Monitoring of different serumproteins after severe trauma and during trauma-induced sepsis. Trial with surgical intervention

Official Title
-----------------
Acute Phase Proteins as Early Markers in Sepsis

Conditions
-----------------
Sepsis

Intervention / Treatment
-----------------
* Procedure: No intervention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: Patients with severe trauma (ISS score > 16), both genders, patients on ICU Exclusion criteria: Moribund patients (pH <7,1, lactate >15mmol, Basedeficit > 15mEq/L, severe heart or liver injuries, GCS never over 5 after trauma) Severe head injuries (AIS head >4) Patient with severe infectious diseases, or diseases which severely affect the immune system (diabetes, Alkohol or nicotine abuse) Non-german speaking patients

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: No intervention|No intervention|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Advanced XLIF Monitoring Pilot Study

Study Overview
=================
Brief Summary
-----------------
Though the utility of NVM5 neuromonitoring by stimulating within the surgical site during XLIF has been demonstrated, it is hypothesized that more information may be gathered if a greater section of the motor neural pathway was monitored (i.e., stimulation above the surgical site and recording the subsequent muscle response in the lower limbs). Currently, there has not been demonstrated a practical method of stimulating the lumbosacral nerve roots locally, but well-above the surgical site in this fashion. This protocol is intended to evaluate the feasibility and reproducibility of using surface stimulation and return (anode) electrodes to stimulate the lumbosacral nerve roots, and record responses from the relevant innervated muscle groups of the lower limbs.

Official Title
-----------------
Evaluation of Transcutaneous Stimulation of Lumbosacral Nerve Roots: A Pilot Study

Conditions
-----------------
Degenerative Lumbar Disc Disease

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Male and female spine surgery patients who are at least 18 years of age Surgical candidates for lateral approach lumbar spine surgery at spinal levels L2 to L5, inclusive of L4-5 Patients who understand the conditions of enrollment and are willing to sign an informed consent to participate in the evaluation Exclusion Criteria: Currently undergoing surgical treatment at any spinal level other than L2 to L5, including S1 Pregnant women Implanted pacemaker, defibrillator, or other electronic devices Involved in active litigation relating to the spine (worker's compensation claim is allowed if it is not contested) Underlying neurological disease or neurological deficit that is not associated with the condition for which he/she is seeking surgical intervention (e.g., diabetic peripheral neuropathy)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Reproducibility of obtaining reliable responses and response thresholds monitored over the course of surgery. |  | Intraoperative | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation of any observed changes in the response or response thresholds with surgical events. |  | Intraoperative | 
| Correlation between patient characteristics and the ability to generate and reliably record responses and response thresholds. |  | Intraoperative | 
| Correlation between observed changes in the response or response threshold and postoperative neural status. |  | 6 weeks postoperative |