Glypican4 and CTRP5 in Metabolic Syndrome and the Effect of Exercise on These Adipokines

Study Overview
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Brief Summary
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Glypican4, CTRP3, CTRP5 are emerging novel adipokines mediating obesity and inflammation related disorders. RBP4 and adiponectin are well known important adipokines. Therefore, we examine the circulating levels of theses adipokines in the subjects with or without metabolic syndrome. Furthermore, we tried to clarify the effect of exercise on the circulating these adipokines.

Official Title
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Effects of Exercise on Glypican4,CTRP3,5 and RBP4 Levels and Circulating Levels of These Adipokines in the Subjects With or Without Metabolic Syndrome

Conditions
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Metabolic Syndrome, Obesity

Intervention / Treatment
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* Behavioral: 3months Exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Women between 30 and 60 years of age who had a body mass index (BMI) more than 25 kg/m2 The subjects of metabolic syndrome and age, gender matched non metabolic syndrome among the participants of Korean SO Study (KSOS) study, which is an ongoing epidemiologic study supported by the Korea Science and Engineering Foundation Exclusion Criteria: participants had a history of cardiovascular disease any type of diabetes stage 2 hypertension malignant disease, severe renal, or hepatic disease Subjects taking medications that might affect body weight or body composition

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Exercise<br>obese women who are volunteers for the 3 months exercise programs | Behavioral: 3months Exercise<br>* training session consisting of a brief warm-up, followed by an approximately 45-min session of aerobic exercise at an intensity of 60-75% of the age-predicted maximum heart rate (approximately 300 kcal/day) and a 20-min muscle strength train- ing programme (approximately 100 kcal/day), followed by a brief cool-down period.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The changes of circulating glypican4 levels after 3 months exercise |  | baseline and 12weeks | 
| The changes of circulating CTRP3 levels after 3 months exercise |  | baseline and 12weeks | 
| The changes of circulating CTRP5 levels after 3 months exercise |  | baseline and 12weeks | 
| The changes of circulating RBP4 levels after 3 months exercise |  | baseline and 12weeks | 
| The changes of circulating adiponectin levels after 3 months exercise |  | baseline and 12weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Circulating glypican4 levels in the subjects with or without metabolic syndrome |  | baseline | 
| Circulating CTRP3 levels in the subjects with or without metabolic syndrome |  | baseline | 
| Circulating CTRP5 levels in the subjects with or without metabolic syndrome |  | baseline | 
| Circulating RBP4 levels in the subjects with or without metabolic syndrome |  | baseline | 
| Circulating adiponectin levels in the subjects with or without metabolic syndrome |  | baseline |