Verification of Computerized Sleep-wake Analysis in Sleep Disorders

Study Overview
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Brief Summary
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Objective: Computerized sleep staging has been verified in a normal population. This study attempts to investigate and verify the interpretation of this computerized sleep staging program in patients with sleep disorders, and improve the accuracy of actigraphy algorithm for sleep duration and postures. Compare the accuracy of computerized sleep-wake analysis with current sleep quality indicators: through actigraphy and heart rate sensors, compare the computerized sleep-wake analysis program with polysomnography, and verify its clinical reliability and validity in sleep disorder patients. Establish the sleep posture detection system: through three-axis accelerometer, develop algorithms for position recording and monitoring during sleep, and upgrade its accuracy according to photography. Methods: Patients ranged from age 20-50 with primary insomnia, periodic limb movement in sleep, simple snores, and obstructive sleep apnea will be enrolled in our study. Routine polysomnography will be applied in sleep center at Chang Gung Memorial Hospital, Taoyuan, as well as sleep-related questionnaires. At the same time, actigraphy and heart rate sensor patch will be used for sleep posture detection and further computerized sleep-wake analysis. Results will be verified the consistency by comparison with sleep-wake analysis from polysomnographic data and sleep-related questionnaires.

Conditions
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Sleep-wake Analysis

Intervention / Treatment
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* Other: Patch III heart rate sensor


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age 20-50 diagnosed as primary insomnia, periodic limb movement in sleep, simple snores, and obstructive sleep apnea Exclusion Criteria: arrhythmia sleep efficiency<50% combined other sleep disorders

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Primary insomnia<br>Primary insomnia patients, without combined any other sleep disorders | Other: Patch III heart rate sensor<br> <br> |
| Periodic limb movement in sleep<br>Patients have periodic limb movement in sleep, without combined any other sleep disorders | Other: Patch III heart rate sensor<br> <br> |
| Simple snores<br>Simple snore patients, without combined any other sleep disorders | Other: Patch III heart rate sensor<br> <br> |
| Obstructive sleep apnea<br>Obstructive sleep apnea patients, including mild, moderate and severe types, without combined any other sleep disorders or CPAP treatment during PSG study | Other: Patch III heart rate sensor<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Electrocardiogram and body position signals | Computerized sleep-wake analysis from electrocardiogram and body position signals from Patch III heart rate sensor, and calibrated the sleep staging with AASM sleep scoring reports. | Data recruited during one-night (PSG study) from Patch III heart rate sensor |