Global Non-interventional Heart Failure Disease Registry

Study Overview
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Brief Summary
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The clinical characteristics, initial presentation, management, and outcomes of patients hospitalized with new-onset (first diagnosis) heart failure (HF) or decompensation of chronic HF are poorly understood worldwide. REPORT-HF is a global, prospective, and observational HF disease registry designed to characterize patient trajectories longitudinally during and following an index hospitalization for acute HF.

Official Title
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International Registry to Assess mEdical Practice With lOngitudinal obseRvation for Treatment of Heart Failure

Conditions
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Acute Heart Failure

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients at least 18 years old, or older for those countries where the adult age is above 18 years of age, hospitalized with a primary diagnosis of acute heart failure. Exclusion Criteria: 1-Concomitant participation in any/a clinical trial with any investigational treatment (for any sponsor). 2. Use of investigational drugs within 5 half-lives of enrollment, or until the expected pharmacodynamic effect has returned to baseline, whichever is longer.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patients with different characteristics of heart faliure (HF) at hospitalization |  | From admission to discharge of the patient's index hospitalization (minimum 24 hours) | 
| Percentage of patients who die during the index hospitalization |  | From admission to discharge of the patient's index hospitalization (minimum 24 hours) | 
| Percentage of patients who die during the follow-up period post-discharge |  | up to 3 years | 
| Percentage of patients who are re-hospitalized by primary re-hospitalization reason (Cardiovascular and non-Cardiovascular) |  | up to 3 years | 
| Number of patients with different characteristics of post-discharge patient management |  | up to 3 years | 
| Healthcare Resource Utilization assessed by number of patients with re-hospitalizations |  | up to 3 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Health-related Quality of life (HRQoL) based on patient reported data as measured by EQ-5D and the Kansas City Cardiomyopathy Questionnaire (KCCQ) questionnaires |  | up to 3 years | 
| Caregiver burden based on Caregiver Burden Questionnaire -Heart Failure (CBQ-HF) and Work Productivity and Activity Impairment (WPAI) questionnaires |  | up to 3 years | 
| Correlation ratio between practice patterns and outcomes |  | up to 3 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Registry, Heart failure, Hospitalized, Global, Morbidity, Mortality, Quality of life, AHF