Very Long Term Results After Laparoscopic Retrocolic Antegastric Gastric Bypass

Study Overview
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Brief Summary
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The main aim of this study is to analyze and report the very long-term outcomes after primary laparoscopic proximal Roux-en-Y gastric bypass surgery for clinically severe obesity.

Detailed Description
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There is lack of very-long term outcomes after bariatric surgery; A few series have been reported. However, most of them analyze medium-term outcomes. For RYGB, there are just two retrospective cohort studies reporting very long-term outcomes. Both studies have an open approach and a proximal Roux-en-Y configuration with different pouch orientation and size. MacLean´s series, with a better follow-up rate (83.4%), had a 67.6%EWL at a mean of 11.4 years; Failure rates were 20 and 35% for the morbidly obese and super obese, respectively. We will analyze our own series with a laparoscopic approach, vertically, lesser-curve base < 10-15ml pouch and proximal Roux limb. The main end-points for our study are 1) Morbidity including status of specific biochemical markers & Mortality, 2) Weight loss expressed as BMI or %EWL, 3) Trends in major comorbidities and 4) Assessment of Quality of Life.

Official Title
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Very Long Term Results After Laparoscopic Retrocolic Antegastric Gastric Bypass

Conditions
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Clinically Severe Obesity

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients who met NIH criteria for recommendation of a bariatric procedure with a combination of the following characteristics status post primary laparoscopic proximal RYGB surgery with or without subsequent open or laparoscopic revisions or re-operations follow up > 10.0 years (Very long term outcome) Exclusion Criteria: patients who had a previous gastric or bariatric procedure patients who underwent primary laparoscopic RYGB somewhere else by other surgical group missing records and/or unreachable patients with scant information for analysis

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| primary laparoscopic gastric bypass<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Weight loss expressed as Body Mass Index and Percentage excess weight loss |  | throughout follow-up | 
| Comorbidity status |  | throughout follow-up | 
| Health-related Quality of Life (HR-QoL) |  | at last follow-up | 
| Subjective satisfaction |  | at the last follow-up | 
| Morbidity and mortality |  | throughout follow-up | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Nutritional and metabolic status |  | throughout follow-up | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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severe obesity, morbid obesity, gastric bypass, efficacy of gastric bypass