Stress in Couples Undergoing Assisted Reproduction Technology With Different Cycles and Its Impact on Pregnancy Outcomes

Study Overview
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Brief Summary
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With the development of assisted reproductive technology (ART), more and more infertile women are obtaining their offspring through assisted reproductive technology. However, a growing number of national and international studies have shown that infertility patients are prone to negative emotions such as anxiety and depression during ART treatment, which not only affects their physical and mental health, but also affects the embryo implantation rate and pregnancy rate of ART. The purpose of this study is to investigate the stress faced by participants undergoing ART with different cycles and to further investigate its impact on pregnancy outcomes.

Detailed Description
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With the rapid social and economic development in recent years, the incidence of infertility has increased significantly due to environmental pollution, poor lifestyle habits and increasing stress in various areas. According to global statistics, one in six married couples suffers from infertility. With the development of assisted reproductive technology (ART), more and more infertile women are obtaining their offspring. In clinical practice, however, a significant proportion of patients undergoing ART have low embryo implantation and pregnancy rates and experience recurrent implantation failure (RIF). A growing number of national and international studies have shown that infertility patients are prone to negative emotions such as anxiety and depression during ART treatment, which not only affects their physical and mental health, but also affects the embryo implantation rate and pregnancy rate of ART. This effect is more pronounced in patients with multiple failed transfers. In this study, investigators intend to investigate the stress faced by participants undergoing assisted reproduction with different cycles to provide a reliable basis for future psychological interventions and health education for this group of patients and improve the quality of life of infertility patients.

Official Title
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Stress in Couples Undergoing Assisted Reproduction Technology With Different Cycles and Its Impact on Pregnancy Outcomes

Conditions
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Infertility

Intervention / Treatment
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* Other: cycles


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Female partners' >18< 40 years Patients undergoing assisted reproductive technology Exclusion Criteria: Female partners with polycystic ovary Female partners with insufficiency or premature ovarian failure Female partners with endometriosis Female partners with abnormal profile of thyroid hormones Chromosomal abnormalities of either spouse Mental disorder of either spouse

Ages Eligible for Study
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Minimum Age: 16 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients undergoing assisted reproductive technology<br>Patients undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) | Other: cycles<br>* Patients are grouped according to the number of IVF/ICSI cycles.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Implantation rate | Implantation rate is defined as number of sacs per embryo transferred. | 6 months | 
| clinical pregnancy rate | presence of at least one gestational sac on ultrasound of 6 weeks | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| fertilization rate | No. of fertilized oocyte divided by No. of inseminated cumulus-oocyte complexes (COCs) | 6 months | 
| cleavage rate | No. of cleaved embryo divided by No. of fertilized oocyte | 6 months | 
| Total gonadotropin use | Total gonadotropin use of each participant | 6 months | 
| Ovarian hyperstimulation syndrome (OHSS) rates | OHSS rates in both study groups | 6 months | 
| Number of oocytes retrieved |  | 6 months | 
| Metaphase II (MII) oocytes | the number of mature oocytes | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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infertility, cycle