linjc16/ctgov huggingface dataset:
Early Markers of Radiation-Induced Cardiac Injury in Hodgkin Lymphoma Treated With Radiation Therapy

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate if radiation and chemotherapy treatment cause cardiac abnormalities among survivors of Hodgkin's lymphoma.

Official Title
-----------------
UFPTI 1431 - HL02: Investigating Early Markers of Radiation-Induced Cardiac Injury in Hodgkin Lymphoma Survivors Treated With Either Photon or Proton Radiation

Conditions
-----------------
Hodgkin's Lymphoma

Intervention / Treatment
-----------------
* Procedure: Cardiac Magnetic Resonance Imaging
* Procedure: Echocardiogram


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Completed radiation and chemotherapy treatment for Hodgkin lymphoma involving the mediastinum. Patient must be ≥ 18 years at time of consent. Exclusion Criteria: Pregnant women at time of Cardiac MRI Contraindications to Cardiac MRI (contrast allergy, metal implants, medical devices) Glomerular filtration rate (GFR) < 30, unless approved by Radiologist (UF Health Jacksonville Radiology Policy: Administration of Gadolinium-Based Contrast Agents).

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Survivors of Hodgkin's lymphoma<br>Cardiac Magnetic Resonance Imaging and Echocardiogram | Procedure: Cardiac Magnetic Resonance Imaging<br>* A cardiac MRI will be performed.<br>Procedure: Echocardiogram<br>* An echocardiogram will be performed for the following information: M-mode, two-dimensional, Doppler blood flow measurements, and longitudinal strain and strain rate imaging<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cardiac Abnormalities As Measured By Cardiac MRI |  | Day 1 | 
| Cardiac Abnormalities As Measured By Echocardiogram |  | Day 1 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Radiation, Cardiac, Hodgkin's lymphoma
Minimally Invasive Techniques Or Surgery In the Diagnosis of Sarcoidosis

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate the yield of endoscopic guided fine needle aspirations (by means of transoesophageal endoscopic ultrasound : EUS-FNA or transbronchial endoscopic ultrasound : EBUS-TBNA) in patients with a clinical suspicion for sarcoidosis stage I-II; but in whom the preceding bronchoscopy did not result in a qualifying diagnosis.

Official Title
-----------------
Minimally Invasive Techniques Or Surgery In the Diagnosis of Sarcoidosis (MITOSIS-Trial)

Conditions
-----------------
Sarcoidosis

Intervention / Treatment
-----------------
* Procedure: Bronchoscopy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age ≥ 18 y Suspicion of thoracic sarcoidosis and need for tissue confirmation Recent (<6 weeks) RX and CT-thorax (HRCT not compulsory) Fit for bronchoscopy (with or without EBB, TBB, TBNA), esophagoscopy and surgery Written informed consent Exclusion Criteria: Patients with obvious other organ involvement allowing simple and safe biopsy Lofgren syndrome Pregnancy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Bronchoscopy<br>Bronchoscopy, only if no diagnosis is obtained, patients go for EUS-FNA or EBUS-TBNA, only if no diagnosis is obtained, patients go for surgical biopsy | Procedure: Bronchoscopy<br>* Bronchoscopy, only if no diagnosis is obtained, patients go for EUS-FNA or EBUS-TBNA, only if no diagnosis is obtained, patients go for surgical biopsy<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The diagnostic yield of state-of-the art bronchoscopy (including TBB, EBB and TBNA) |  | At the end of study | 
| The role of endosonography (EUS-FNA or EBUS-TBNA) in demonstrating non-caseating granulomas after a non-qualifying bronchoscopy |  | At the end of study | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prevalence of sarcoidosis and alternate diagnosis |  | At the end of study | 
| Stage distribution |  | At the end of study | 
| Complication rate of each type of procedure |  | At the end of study | 
| Cost to obtain a qualifying diagnosis with this strategy in this population |  | At the end of study |
Magnetic Resonance Imaging Evaluation of Lateral Ankle Instability

Study Overview
=================
Brief Summary
-----------------
Lateral ankle instability may be acute or chronic. Acute instability usually occurs due to extreme rear foot supination with planter-flexion trauma leads to injury of lateral collateral ligament complex especially the anterior talofibular ligament. Most ankle ligamentous injuries are treated conservatively. However, 20% to 40% of patients complain of chronic instability and persistent discomfort. Structural instability, loss of proprioceptive capabilities, and the weakness of peroneal muscles seem to induce chronic instability

Official Title
-----------------
Magnetic Resonance Imaging Evaluation of Lateral Ankle Instability

Conditions
-----------------
Ankle Injuries

Intervention / Treatment
-----------------
* Procedure: magnetic resonance imaging.


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: - Patients with any sex, age, complaining of chronic lateral ankle pain. Exclusion Criteria: Tumors at ankle region. Postoperative status around the ankle. Rheumatoid arthritis. Comminuted fracture at the ankle. Congenital anomalies of the ankle.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| study group<br>patients with history of ankle trauma or chronic lateral ankle pain | Procedure: magnetic resonance imaging.<br>* 1.5 Tesla magnet system is going to be utilized for ankle imaging. A dedicated extremity surface coil (Foot/Ankle 16-Channel Coil; Siemens Medical Solution) is used to enhance spatial resolution.<br>* Other names: MRI.;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The percentage of patients with ankle or ligaments abnormalities by examination | Magnetic resonance imaging examination will be the method for diagnosis | 30 minutes |
Biomarker Expression in Samples From Young Patients With Anaplastic Large Cell Lymphoma

Study Overview
=================
Brief Summary
-----------------
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer. it may also help doctors predict how patients will respond to treatment. PURPOSE: This research trial studies biomarker expression in tissue samples from young patients with anaplastic large cell lymphoma.

Detailed Description
-----------------
OBJECTIVES: To determine the expression of immunoregulatory proteins including CD4, FOXP3 and CD276 in anaplastic large cell lymphoma (ALCL). To correlate the expression of these proteins with the levels of anaplastic lymphoma kinase (ALK) autoantibodies in patient of ANHL0131. OUTLINE: Archived tissue microarray samples are analyzed by mass spectrometry and validated by Western blotting, flow cytometry, and IHC.

Official Title
-----------------
Expression of T Immunoregulatory Proteins in ALK+ Anaplastic Large Cell Lymphoma (ALCL)

Conditions
-----------------
Lymphoma

Intervention / Treatment
-----------------
* Genetic: microarray analysis
* Genetic: protein expression analysis
* Genetic: western blotting
* Other: flow cytometry
* Other: immunohistochemistry staining method
* Other: laboratory biomarker analysis
* Other: mass spectrometry


Participation Criteria
=================
Eligibility Criteria
-----------------
DISEASE CHARACTERISTICS: Diagnosis of anaplastic large cell lymphoma Tissue microarray samples available from the Cooperative Human Tissue Network (CHTN) PATIENT CHARACTERISTICS: Not specified PRIOR CONCURRENT THERAPY: Not specified

Ages Eligible for Study
-----------------
Maximum Age: 20 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Genetic: microarray analysis|nan|
|Genetic: protein expression analysis|nan|
|Genetic: western blotting|nan|
|Other: flow cytometry|nan|
|Other: immunohistochemistry staining method|nan|
|Other: laboratory biomarker analysis|nan|
|Other: mass spectrometry|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Expression of immunoregulatory proteins including CD4, FOXP3 and CD276 in ALCL |  |  | 
| Correlation of CD4, FOXP3, and CD276 with ALK autoantibody response in patients enrolled in ANHL0131 |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
childhood anaplastic large cell lymphoma
Lipid Profile of Tenon's Capsule

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to provide data on the lipid profile of the Tenon's capsule in Human glaucomatous eyes and to establish possible relationships with the short term outcome of filtration surgery.

Official Title
-----------------
Lipid Profile of Tenon's Capsule in Glaucoma Patients

Conditions
-----------------
Glaucoma

Intervention / Treatment
-----------------
* Procedure: trabeculectomies, non penetrating deep sclerectomies


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Glaucoma Eligibility for surgery Exclusion Criteria: Patients without Glaucoma

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Glaucoma<br> | Procedure: trabeculectomies, non penetrating deep sclerectomies<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To provide data on the lipid profile of the Tenon's capsule in Human glaucomatous eyes and to establish possible relationships with the short term outcome of filtration surgery. |  | 6 month later | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Glaucoma, Tenon's Capsule, Lipid profile, Assessment of lipid profile in Tenon's capsule in patients with Glaucoma
Telerehabilitation in Multiple Sclerosis

Study Overview
=================
Brief Summary
-----------------
Patients with multiple sclerosis will be randomized into two groups. One group will receive live telerehabilitation sessions 3 times a week over a course of three months. The other group will receive video instructions for aerobic and strengthening exercises. Patients fatigue, sleep quality and quality of life will be measured.

Official Title
-----------------
The Effect on Telerehabilitation on Fatigue and Sleep Quality in Patients With Multiple Sclerosis

Conditions
-----------------
Multiple Sclerosis

Intervention / Treatment
-----------------
* Other: Telerehabilitation
* Other: Video exercise


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosis of multiple scleroisis Exclusion Criteria: Any musculoskeletal condition preventing patients to actively participate in exercise sessions

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Telerehabilitation<br> | Other: Telerehabilitation<br>* Patients will receive telerehabilitation sessions for 12 weeks including aerobic and strengthening exercises<br>|
| Active Comparator: Video exercise<br> | Other: Video exercise<br>* Patients will receive video instructions for home based exercises<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pittsburgh Sleep Quality Scale |  | 3 months |
Biventricular Pacing After Coronary Artery Bypass Grafting (BIVAC)

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine which pacing mode after coronary artery bypass grafting in patients with reduced left ventricular function is hemodynamically favorable.

Detailed Description
-----------------
Patients with severely reduced left ventricular function undergoing coronary artery bypass grafting (CABG) are at an increased perioperative risk and often need prolonged postoperative treatment on intensive care units. A significant portion of these patients require postoperative pacing. Right ventricular pacing has been shown to be hemodynamically deleterious whereas biventricular pacing improves cardiac output in patients with severely reduced left ventricular function and bundle branch block. The purpose of this study is to compare DDD-right ventricular, DDD-biventricular and AAI pacing in CABG patients with an ejection fraction less than 40% in a prospective randomized setting.

Conditions
-----------------
Cardiac Pacing,Artificial, Coronary Artery Bypass, Ventricular Function, Left

Intervention / Treatment
-----------------
* Procedure: Postoperative Pacing


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Elective or urgent coronary artery bypass grafting Preoperative ejection fraction less than 40% Exclusion Criteria: Existing permanent pacemaker or ICD Concomitant valve surgery Preoperative cardiovascular instability requiring intubation or IABP use Chronic renal failure requiring dialysis Failure to provide informed consent

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Postoperative Pacing|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Duration of Intensive Care Treatment |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 30 day mortality |  |  | 
| Major adverse events |  |  | 
| Duration of Hospital Stay |  |  | 
| Hemodynamic parameters |  |  | 
| Inotrope use |  |  | 
| Atrial fibrillation |  |  | 
| Ventricular tachycardia / ventricular fibrillation |  |  | 
| Renal function |  |  | 
| Stability of pacing wires |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
coronary artery bypass grafting, reduced left ventricular function, postoperative pacing, cardiac resynchronization
International Registry on Cardioversion of Atrial Fibrillation (MK-6621-051)

Study Overview
=================
Brief Summary
-----------------
This study will create a prospective registry of consecutive patients with Atrial Fibrillation (Afib) considered for cardioversion treatment to document up-to-date practice of in-hospital treatment, with a focus on the characterization of type of Afib, as well as on treatments applied (drugs, devices, interventions and their combinations), and associated complications within 60 days after enrollment.

Official Title
-----------------
International Registry on Cardioversion of Atrial Fibrillation

Conditions
-----------------
Atrial Fibrillation

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Participant with documented atrial fibrillation (confirmed by electrocardiogram) in the hospital setting at the time of enrollment Planned cardioversion (of atrial fibrillation) Exclusion Criteria: Already enrolled in this or any other clinical trial Atrial flutter

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| All Enrolled Participants<br>Participants with documented atrial fibrillation in the hospital setting for whom a cardioversion is one of the planned therapeutic options | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cardiovascular Disease History of Participants Presenting With Atrial Fibrillation at Baseline (Admission) |  | Baseline (time of admission) | 
| Co-Morbidity in Participants Presenting With Atrial Fibrillation at Baseline (Admission) |  | Baseline (time of admission) | 
| Clinical Type of Atrial Fibrillation at Baseline (Admission) |  | Baseline (time of admission) | 
| Treatments Utilized for Participants for Atrial Fibrillation |  | At time of Treatment (up to 1 day from admission) | 
| Percentage of Participants Who Had a Successful Electrical or Pharmacological Cardioversion | Pharmacological cardioversion was considered successful if sinus rhythm or atrial rhythm was obtained within 24 hours after its initiation. Electrical cardioversion was considered successful if sinus rhythm was obtained and maintained for at least 10 minutes after the last shock was administered. | At time of treatment (up to 1 day from admission) | 
| Complications Experienced by Participants Who Underwent a Cardioversion for Treatment of Atrial Fibrillation |  | up to 60 days from day of treatment (cardioversion) | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
cardioversion, AF, Atrial Fibrillation, Afib, normal sinus rhythm, arrhythmia
Quality of Life (QOL), Coping and Psychological Symptoms in Children and Adolescents With Cyclic Vomiting Syndrome

Study Overview
=================
Brief Summary
-----------------
Characterize the quality of life of young children with CVS (i.e., psychological, social, physical, school functioning) and the impact of the child's illness on the parent's and family's quality of life (i.e., emotional, social, cognitive functioning, communication, worry, daily activities and family relationships). Assess symptoms of depression, anxiety, ADHD and behavioral problems in what our preliminary data suggests is a psychiatrically vulnerable population. Evaluate the associations between quality of life and psychiatric symptoms and the frequency and intensity of CVS attacks. Use the data generated from this study to develop a psychosocial intervention targeted at young children with CVS and their families who evidence risk for functional disability, with the aim of intervening as early as possible to limit the psychological and social morbidity experienced by children with CVS and their and families.

Official Title
-----------------
Quality of Life, Coping and Psychological Symptoms in Children and Adolescents With Cyclic Vomiting Syndrome

Conditions
-----------------
Vomiting Syndrome

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosis of CVS Exclusion Criteria: Children and parents who are not English speaking Youth with significant developmental delay, mental retardation, psychotic symptoms, or other significant mental impairments and those with other major medical disorders such as IDDM, congenital heart disease, cystic fibrosis, etc.

Ages Eligible for Study
-----------------
Minimum Age: 9 Years
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Characterize the quality of life of youth with CVS as well as the strategies they use to cope with stress, their strengths and vulnerabilities, and to assess symptoms of depression and anxiety in these at risk youth. |  | Two years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluate the associations among coping strategies the frequency and intensity of CVS attacks to determine if particular coping styles and personal characteristics are associated illness severity, psychiatric co-morbidity and quality of life. |  | Two years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Youth, Consensus, Criteria, CVS
Feasibility of the Latella Implant System for Medial Osteoarthritis (OA)

Study Overview
=================
Brief Summary
-----------------
The objective of this study is to evaluate the safety and technical feasibility of implanting the Latella Implant System in the treatment of patients with medial osteoarthritis of the knee.

Official Title
-----------------
Evaluation of the Latella Implant System for Lateralization of the Iliotibial Band to Offload the Medial Condyle for Pain Relief in Patients With Medial Osteoarthritis - A Safety Study

Conditions
-----------------
Osteoarthritis

Intervention / Treatment
-----------------
* Device: Latella Knee Implant System


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: History of pain as due to medial osteoarthritis Exclusion Criteria: Rheumatoid arthritis Joint or ligament instability Metal ion allergy

Ages Eligible for Study
-----------------
Minimum Age: 30 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Device Feasibility
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Latella Knee Implant System<br> | Device: Latella Knee Implant System<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Freedom from unanticipated serious adverse device effects |  | 12 Months |