Cord Blood Nesfatin-1 and Irisin in the Intrauterine Growth Restricted Fetuses

Study Overview
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Brief Summary
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: The aim of this study is to investigate Cord blood irisin and nesfatin-1 levels in pregnancies with intrauterine growth retardation and to determine whether they are associated with abnormal fetal doppler findings or not.

Detailed Description
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This study was conducted at Yüzüncü Yıl University Medical Faculty Obstetrics and Gynecology Clinic. The study group included 34 pregnant women ranged from 18 to 45 years old who have intrauterine growth retardation and underwent ceseraen section. 32 pregnant women who had no abnormality on prenatal follow-up and underwent elective ceserean seciton served as control group. The maternal age, height, weight, body mass index (BMI), systolic and diastolic blood pressures were recorded in both groups of patients. Maternal serum total blood count and biochemical parameters were obtained from the laboratory parameters. Gestational week at birth, birth weight, sex, 1st and 5th minute APGAR scores were recorded. Blood samples were collected from all the cases during the cesarean section for measurmenet of nesfatin-1 and irisin by doubly clamped umbilical cord. Blood samples were immediately centrifuged in sterile tubes and maintained at -80 ° C until assessed.

Official Title
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The Association of Cord Blood Nesfatin-1 and Irisin Level With Fetal Doppler Parameters in Pregnancies Complicated With Intrauterine Growth Restricted Fetuses

Conditions
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Nesfatin-1, Irisin, Intrauterine Growth Restriction

Intervention / Treatment
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* Other: cord blood specimen during the delivery


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Pregnant women with intrauterine grwoth rectricted fetuses. Healthy pregnancies Exclusion Criteria: Pregnant women with chronic medical conditions multiple pregnancies fetuses with fetal malfomations or genetic syndromes pregnant women older than 45 years old

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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Female

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Study group<br>Pregnancies complicated with intrauterine growth restricted fetuses | Other: cord blood specimen during the delivery<br>* The cord blood will be taken during the delivery of baby.<br>|
| Control group<br>Healthy pregnancies | Other: cord blood specimen during the delivery<br>* The cord blood will be taken during the delivery of baby.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| cord blood nesfatn-1 level measurement | cord blood levels of nesfatin-1 in pregnancies with intrauterine growth restricted fetuses and healthy pregnancies. | 9 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cord blood irisin level measurement | ord blood levels of irisin in pregnancies with intrauterine growth restricted fetuses and healthy pregnancies. | 9 months |