Feasibility Study and Preliminary Application Study on Iris OCTA

Study Overview
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Brief Summary
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All participants will underwent imaging using the OCTA system (Zeiss) with the anterior segment optical adaptor lens. The main outcomes are iris blood flow density and vascular density.

Detailed Description
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Feasibility study of iris OCTA technology Establishment of iris OCTA database in normal population and analysis of related factors: (1) different sex; (2) different age; (3) different myopic diopter; (4) 24-hour diurnal changes from morning to night; (5) before and after mydriasis; (6) different blood pressure; (7) different intraocular pressure; (8) different blood glucose; (9) before and after exercise. (10) drinking water, tea, coffee and red wine. Analysis of iris OCTA data related to eye diseases:(1) conjunctivitis; (2) glaucoma; (3) childhood myopia; (4) uveitis; (5) diabetic retinopathy; (6) retinal detachment; (7) fundus neovascularization. Influence of commonly used ophthalmic drops on iris OCTA data. Observe the difference of iris OCTA test data before and after treatment: (1) conjunctivitis treated with levofloxacin antibiotics; (2) glaucoma treated with prostaglandins, adrenalines and receptor blockers; (3) childhood myopia treated with atropine drugs (4) uveitis treated with hormonal drugs. (5) diabetic retinopathy treated with vasodilator. Effect on iris OCTA data before and after ophthalmic surgery. (1) cataract, phacoemulsification + intraocular lens implantation; (2) glaucoma, iridectomy; (3) fundus neovascularization, intraocular injection of anti-VEGF; (4) diabetic retinopathy, vitreous surgery.

Official Title
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Feasibility Study and Preliminary Application Study on Noninvasive Iris Optical Coherence Tomography Angiography (OCTA)

Conditions
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Conjunctivitis, Glaucoma, Myopia, Diabetic Retinopathy, Retinal Detachment, Retinal Neovascularization, Unspecified, Uveitis

Intervention / Treatment
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* Diagnostic Test: OCTA (ZEISS)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy volunteers and ophthalmological patients who can understand and agree to cooperate this study will be included. Exclusion Criteria: Patients who can not cooperate with the examination.
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Normal Population<br>Normal population with different gender, different age different, different blood pressure, different ocular pressure, etc. All participants will underwent imaging using the OCTA system (Zeiss) with the anterior segment optical adaptor lens. | |
| Patients with common ophthalmic diseases<br>(1) conjunctivitis; (2) glaucoma; (3) childhood myopia; (4) uveitis; (5) diabetic retinopathy; (6) retinal detachment; (7) fundus neovascularization. All patients will underwent imaging using the OCTA system (Zeiss) with the anterior segment optical adaptor lens. | |
| Patients using eye drops<br>(1) conjunctivitis patients treated with levofloxacin antibiotics; (2) glaucoma patients treated with prostaglandins, adrenaline or receptor blockers drugs; (3) childhood myopia patients treated with atropine drugs; (4) uveitis patients treated with hormones treatment. (5) diabetic retinopathy patients treated with vasodilator. All patients will underwent imaging using the OCTA system (Zeiss) with the anterior segment optical adaptor lens before and after eyedrops. | Diagnostic Test: OCTA (ZEISS)<br>* All participants will underwent imaging using the OCTA system (Zeiss) with the anterior segment optical adaptor lens.<br>|
| Ocular surgery patients<br>(1) cataract, phacoemulsification + intraocular lens implantation; (2) glaucoma, iridectomy; (3) fundus neovascularization, intraocular injection of anti-VEGF; (4) diabetic retinopathy, vitrectomy. All patients will underwent imaging using the OCTA system (Zeiss) with the anterior segment optical adaptor lens before and after surgery. | Diagnostic Test: OCTA (ZEISS)<br>* All participants will underwent imaging using the OCTA system (Zeiss) with the anterior segment optical adaptor lens.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Iris Vessel Geometric Characteristics | Iris vascular density and neovascular density | 0:00 8:00 14:00 20:00 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Iris Vessel, OCTA