COVID-19 Patient Cohort: Retinal Damage in Non-invasive Retinal Imaging (OCTA)

Study Overview
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Brief Summary
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The objective of this research is to build a collection of non-invasive retinal imaging (OCT and OCTA) in order to investigate the incidence and impact of retinal damage in patients who have or have had COVID-19.

Detailed Description
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This monocentric study is aimed at 3 types of patients: Those who have been hospitalized for Covid-19 during the epidemic Newly infected and diagnosed patients Covid-19 Those with paucisymptomatic Covid-19 who did not require hospitalisation At the patient's inclusion, an ophthalmologic assessment will be performed including : visual acuity, SD-OCT + multicolor, OCT-A, color retinography, Fundus examination, optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) in all COVID-19 patients may detect retinal lesions. In addition, if a correlation is demonstrated between clinical and paraclinical parameters and between disease severity and retinal vascular damage in non-invasive imaging (OCT and OCTA), this would allow a better understanding of the pathophysiology of the disease, as well as factors that may influence disease severity and the mechanisms potentially responsible for the observed disorders.

Official Title
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COVID-19 Patient Cohort: Retinal Damage in Non-invasive Retinal Imaging (OCTA)

Conditions
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Covid19, Retina Injury

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age ≥ 18 years old Diagnosis of COVID-19 proven on RT-PCR, antigenic test or chest CT scan Affiliation to the general social security system A consent signed by the patient Exclusion Criteria: - Refusal of patient participation

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Retinal damage at inclusion after Covid-19 infection | Comparison of retinal damage in patients with patients with severe forms of Covid-19 versus patients with mild forms of the disease | Up to one week after inclusion | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of retinal vascular density at inclusion after Covid-19 infection | Comparison of retinal damage in patients with severe forms of Covid-19 versus patients with mild forms of the disease | Up to one week after inclusion | 
| Impact of retinal vascular density changes on visual acuity at inclusion | Severity and impact of retinal damage | Up to one week after inclusion | 
| Presence of Retinal toxicity (atrophy) on multimodal retinal imagery | Correlation between the presence of changes in multimodal imaging (fundus autofluorescence, multicolor and OCTA) and the associated antiviral treatment for Covid-19. | Up to one week after inclusion | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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OCT, OCT-A