Relationship of PNI and Clinical Outcome in Patients Undergoing Brain Tumor Surgery

Study Overview
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Brief Summary
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There are several predictors of clinical outcome in patients undergoing brain tumor surgery. Among those, nutritional parameters and calculated nutritional index are known to have ability to predict mortality and clinical outcomes in some patients with brain tumor. However, there are lack of consistent results on predictability of nutritional index and clinical outcome in patients undergoing brain tumor surgery.

Detailed Description
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In this retrospective study, we evaluated the relationship between prognostic nutritional index, which was calculated from laboratory parameters, and clinical outcome including mortality in patients undergoing brain tumor surgery.

Official Title
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Relationship of PNI and Clinical Outcome in Patients Undergoing Brain Tumor Surgery

Conditions
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Clinical Outcome

Intervention / Treatment
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* Diagnostic Test: prognostic nutritional index calculated from laboratory parameters


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: adult patients undergoing brain tumor surgery at Seoul National University Hospital, South Korea Exclusion Criteria: Lack of results of laboratory parameters, such as serum albumin, lymphocyte count, cholesterol Lack of data on clinical outcome, including mortality, acute kidney injury, renal replacement therapy, length of hospital stay, and other major adverse outcome

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| brain tumor surgery<br>adult patients undergoing brain tumor surgery | Diagnostic Test: prognostic nutritional index calculated from laboratory parameters<br>* Calculated nutritional index using laboratory results of serum albumin, lymphocyte count, and cholesterol<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| predictability of prognostic nutritional index for mortality after brain tumor surgery | Odds ratio of prognostic nutritional index for postoperative mortality | From date of surgery until the date of death from any cause, whichever came first, assessed up to 50 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| predictability of prognostic nutritional index for acute kidney injury after brain tumor surgery | Odds ratio of prognostic nutritional index for postoperative acute kidney injury | From date of surgery until the date of acute kidney injury from any cause, whichever came first, assessed up to 50 years | 
| predictability of prognostic nutritional index for renal replacement therapy after brain tumor surgery | Odds ratio of prognostic nutritional index for postoperative renal replacement therapy | From date of surgery until the date of renal replacement therapy from any cause, whichever came first, assessed up to 50 years | 
| relationship of prognostic nutritional index for length of hospital stay after brain tumor surgery | Odds ratio of prognostic nutritional index for length of hospital stay | From date of surgery until the date of hospital discharge | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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nutritional index, brain tumor surgery, mortality