Molecular and Imaging Studies of Cardiovascular Health and Disease

Study Overview
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Brief Summary
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Biobank is a program which collects biological samples, health information and imaging data from consented patients and stored them at the core facility. These information would be used to study the molecular, imaging and outcome studies of cardiovascular health and disease.

Detailed Description
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This program recruits patient from National Heart Centre Singapore and collects their biological sample, health information and imaging data.The donated biospecimens will be stored indefinitely and used for any future research on molecular, imaging and outcome studies of cardiovascular health and disease.The same biological samples and imaging data will be obtained from consented healthy volunteers for comparison.

Official Title
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Molecular and Imaging Studies of Cardiovascular Health and Disease

Conditions
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Healthy, Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy, Ischemic Heart Disease

Intervention / Treatment
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* Other: Cardiovascular Magnetic Resonance
* Other: Fatmass measurement


Participation Criteria
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Eligibility Criteria
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There is no inclusion/exclusion criteria except for the age limit as this is a repository program. Inclusion Criteria: •Subject aged ≥ 16 years and ≤ 90 years. Exclusion Criteria: •No

Ages Eligible for Study
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Minimum Age: 16 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Healthy Volunteer<br>Subjects will undergo the following study procedure: Cardiovascular Magnetic Resonance Imaging and fatmass measurement | Other: Cardiovascular Magnetic Resonance<br>* For the evaluation of heart function and structure of the cardiovascular system.<br>Other: Fatmass measurement<br>* It utilizes a scale machine to measure the body fat and skeletal muscle percentage<br>|
| Dilated Cardiomyopathy<br>Subjects will undergo the following study procedure: Cardiovascular Magnetic Resonance Imaging and fatmass measurement | Other: Cardiovascular Magnetic Resonance<br>* For the evaluation of heart function and structure of the cardiovascular system.<br>Other: Fatmass measurement<br>* It utilizes a scale machine to measure the body fat and skeletal muscle percentage<br>|
| Hypertrophic cardiomyopathy<br>Subjects will undergo the following study procedure: Cardiovascular Magnetic Resonance Imaging and fatmass measurement | Other: Cardiovascular Magnetic Resonance<br>* For the evaluation of heart function and structure of the cardiovascular system.<br>Other: Fatmass measurement<br>* It utilizes a scale machine to measure the body fat and skeletal muscle percentage<br>|
| Ischemic heart disease with reduced EF<br>Subjects will undergo the following study procedure: Cardiovascular Magnetic Resonance Imaging and fatmass measurement | Other: Cardiovascular Magnetic Resonance<br>* For the evaluation of heart function and structure of the cardiovascular system.<br>Other: Fatmass measurement<br>* It utilizes a scale machine to measure the body fat and skeletal muscle percentage<br>|
| Ischemic heart disease with normal EF<br>Subjects will undergo the following study procedure: Cardiovascular Magnetic Resonance Imaging and fatmass measurement | Other: Cardiovascular Magnetic Resonance<br>* For the evaluation of heart function and structure of the cardiovascular system.<br>Other: Fatmass measurement<br>* It utilizes a scale machine to measure the body fat and skeletal muscle percentage<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Numbers of genetic variation in genes known to cause inherited cardiac condition and circulating biomarkers which are linked with DNA changes using advanced sequencing and informatics approaches |  | 10 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Healthy Volunteer, Dilated cardiomyopathy, Hypertrophic cardiomyopathy, ischemic heart disease, Cardiovascular Magnetic Resonance Imaging