Personalized Computerized Inhibitory Control Training for OCD

Study Overview
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Brief Summary
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This study will evaluate the effects of a computerized training program coupled with cognitive behavioral therapy (CBT) for OCD.

Detailed Description
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This study will evaluate the effectiveness of a computerized training program (called Personalized Computerized Inhibitory Training, or PCIT) coupled with cognitive behavioral therapies (CBT) consisting of Exposures and Response Prevention in treating obsessive compulsive disorder (OCD) in patients who previously underwent CBT, but still have residual symptoms.

Official Title
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Personalized Computerized Inhibitory Control Training for OCD

Conditions
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Obsessive-Compulsive Disorder

Intervention / Treatment
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* Behavioral: Personalized Computer Program
* Behavioral: Cognitive Behavioral Therapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Principal diagnosis of OCD (assessed by SCID). Clinically significant OCD symptoms (Y-BOCS score of at least 16). Have a history of completing a trial of at least 1 EX/RP sessions. Have access to a computer or laptop. Exclusion Criteria: Individuals with the following disorders will excluded: bipolar, psychosis, current major depressive disorder (assessed by SCID). Patients with head injury and loss of consciousness of more than five minutes or a neurological condition affecting the central nervous system. Patients taking a psychiatric medication will be asked to maintain a stable dose for 6 weeks prior to study entry. Vision or hearing loss (although individuals with vision corrected by glasses or contacts will not be excluded). Active suicidality warranting immediate clinical care.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: CBT + Personalized Computer Program<br>Cognitive Behavioral Therapy (CBT), consisting of Exposure and Ritual Prevention Therapy and training with a personalized computerized inhibitory training program | Behavioral: Personalized Computer Program<br>* Training with a personalized computerized inhibitory training program<br>Behavioral: Cognitive Behavioral Therapy<br>* Cognitive Behavioral Therapy (CBT), consisting of Exposure and Ritual Prevention Therapy<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Obsessive-compulsive symptoms measured after 3 weeks of treatment | measured by Yale Brown Obsessive Compulsive Scale (YBOCS) | 3 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cognitive Behavioral Therapy