Brisk Walking Study in Nursing Home Residents

Study Overview
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Brief Summary
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It is well established that physical activity reduces the physiological effects of ageing. Among them, the decrease of the autonomic nervous system activity (ANS) is associated with the increase of cardiovascular events and sleep disorders occurence. It has been shown that high intensity cycle training can enhance the ANS activity by 30% in people aged of 70 years old. However, such trainings were done by old athletes used to train at intensities that could not be handled by nursing home elderly. Thus, an adapted activity such as brisk walking shall be defined to make it practicable for the many in convalescent homes. The investigators hypothesize that long term brisk walking training could lead to reactivate ANS in people living in convalescent homes.

Detailed Description
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The investigators aim to compare the effects of a 9 month brisk walking training (1 time a week or 3 times a week) on the ANS of nursing home residents.

Official Title
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Effects of Brisk Walking on Autonomic Nervous System Reactivation in Nursing Home Residents.

Conditions
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Physical Activity, Autonomic Nervous System Imbalance

Intervention / Treatment
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* Behavioral: Brisk walking


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Being over 60 years old Living in a nursing home of Mutualité Française de la Loire, France Being able to walk without human aid Being able to speak and write French Being inactive (less than 1 hours of physical activity per week) Having a normal sinus rhythm Being affiliated to the social welfare system Signing the informed consent form Exclusion Criteria: Having serious balance disorders Suffering from cardiac or respiratory pathologies that contraindicate physical activity Serious comorbidities contraindicating physical activity Diagnosed cardiac pathologies that prevent heart rate variability analysis: congestive heart failure, cardiac pacemaker, implantable cardioverter defibrillator, serious ventricular rhythm troubles, atrial fibrillation, atrial flutter. Persons under legal protection

Ages Eligible for Study
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Minimum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Brisk walking 1<br>1 time a week of 9 months brisk walking | Behavioral: Brisk walking<br>* Prospective randomized clinical trial with 2 intervention groups and 1 control group.<br>|
| Experimental: Brisk walking 3<br>3 times a week of 9 months brisk walking | Behavioral: Brisk walking<br>* Prospective randomized clinical trial with 2 intervention groups and 1 control group.<br>|
| No Intervention: Control group<br>No brisk walking session | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| SDNN value | Standard deviation of all normal nocturnal RR intervals | 9 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Heart rate variability parameters | Autonomic nervous system balance (RMSSD) | 9 months | 
| Heart rate variability parameters | Autonomic nervous system balance (LF/HF) | 9 months | 
| Heart rate variability parameters | Autonomic nervous system balance (Ptot) | 9 months | 
| Baroreflex sensitivity (BRS) | BRS slope variation measured at rest | 9 months | 
| Maximum oxygen uptake (VO2max) | Cardiopulmonary exercise testing | 9 months | 
| Daily physical activity | Actimetry (Actigraph-GT3X) | 9 months | 
| Daily physical activity | Adult physical activity questionnaire (APAQ) | 9 months | 
| Sedentary periods | Actimetry (Actigraph GT3X) | 9 months | 
| Sedentary periods | Adult physical activity questionnaire (APAQ) | 9 months | 
| Muscular force | Lower limbs maximum voluntary force test measured on force chair | 9 months | 
| Muscular endurance | Lower limbs endurance test measured on force chair | 9 months | 
| Muscular volume gains | Lower limbs muscular magnetic resonance imaging (MRI) | 9 months | 
| Plasmatic dosages of inflammatory molecules | CRP | 9 months | 
| Plasmatic dosages of inflammatory molecules | TNF alpha | 9 months | 
| Plasmatic dosages of inflammatory molecules | IL 17 | 9 months | 
| Cognitive improvements | Neuropsychological evaluation with a neuropsychologist. | 9 months | 
| Quality of life | SF-36 questionnaire | 9 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Nursing home residents, Brisk walking