Dual-task Performance in Young-onset PD

Study Overview
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Brief Summary
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This study aimed to investigate the effects of Game based dual-task training with treadmill on executive function and dual-task performance in individuals with early-onset PD and discuss the correlation between the change values of executive function and dual-task performance after training. Besides, investigate cortical activation after training.

Official Title
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Decrement of the Dual-task Performance in Individuals With Young-onset Parkinson's Disease and the Training Effects

Conditions
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Early Onset Parkinson Disease, Early Stage Parkinson Disease

Intervention / Treatment
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* Other: Game based dual-task training
* Other: Treadmill training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosed as PD and Hoehn and Yahr stage between 1 3 Age between 20 to 80 Able to walk 10 m independently without an assistive device A score of greater than or equal to 24 on the mini-mental state examination (MMSE) In stable medical condition allowing participation in the testing protocol and intervention Exclusion Criteria: Any comorbidity or disability other than PD that would preclude gait training Any uncontrolled health condition for which exercise was contraindicated Any neurological or orthopedic disease that might interfere with the study Server freezing of gait, FOG questionnaire > 15

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Game based dual-task training group<br>Participants in dual-task training group will execute game based dual-task training with treadmill, 3 times per week for 8 weeks | Other: Game based dual-task training<br>* Participants in the experimental group will receive game based dual-task training with a treadmill<br>|
| Active Comparator: Treadmill training group<br>Participants in treadmill training group will do treadmill training, 3 times per week for 8 weeks | Other: Treadmill training<br>* Participants in the control group will receive treadmill training<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Dual-task walking performance | To evaluate gait parameters while doing dual-task walking | Change from baseline at 8 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Single walking performance | To evaluate gait parameters while doing single walking | Change from baseline at 8 weeks | 
| Timed up and go test | To evaluate functional walking ability | Change from baseline at 8 weeks | 
| Parkinson's Disease Questionnaire 39 | To evaluate the quality of life | Change from baseline at 8 weeks | 
| Frontal lobe battery test-Chinese version | To evaluate executive function | Change from baseline at 8 weeks | 
| Trail-making test | To evaluate executive function | Change from baseline at 8 weeks | 
| Stroop color and word test-Chinese version | To evaluate executive function | Change from baseline at 8 weeks | 
| Verbal fluency test-Chinese version | To evaluate executive function | Change from baseline at 8 weeks | 
| Digit span test | To evaluate executive function | Change from baseline at 8 weeks | 
| Dual-task costs | To compare the cost between doing dual task and single task | Change from baseline at 8 weeks | 
| Functional near-infrared spectroscopy | To evaluate the changes of blood perfusion in frontal lobe | Change from baseline at 8 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Executive function, Dual-task performance, Dual-task training