The Effect of Neuromuscular Electrical Stimulation (NMES) on the Renal Function and Renal Blood Flow

Study Overview
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Brief Summary
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A randomized prospective controlled study aims to evaluate the effect of neuromuscular electrical stimulation on the renal function and renal blood flow of post partum women with acute kidney injury.

Official Title
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The Effect of Neuromuscular Electrical Stimulation (NMES) on the Renal Function and Renal Blood Flow for Patients With Pregnancy Related- Acute Kidney Injury

Conditions
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Renal Injury

Intervention / Treatment
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* Procedure: neuromuscular electrical stimulation (NMES) in addition to routine hospital care
* Procedure: routine hospital care without NMES


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients aged 18 or old and hemodynamically stable. Post-partum women who developed AKI. Exclusion Criteria: Pregnant women . Patients who required any emergency or elective surgery during the study; those who presented acute heart or lung disease, skin rashes, tumors, infections, diabetes mellitus or hypoesthesia in the region that the neuromuscular electrical stimulation would be applied. Patients with a Pacemaker. Epileptic Patients. Patients with recent effects of stroke (less than 3 months). Uncontrolled hypertension (systolic blood pressure > 230 mm Hg and diastolic blood pressure > 120 mm Hg).

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: NMES group<br> | Procedure: neuromuscular electrical stimulation (NMES) in addition to routine hospital care<br>* Patients in the NMES group will receive NMES sessions as the electrodes will be placed around the bilateral femoral quadriceps muscles and at the site of renal arteries. NMES(>100 Hz, 50-80 μ sec) will be performed for 55 min including 5 minutes for warm up and 5 minutes for recovery . The intensity of electrical stimulation will be adjusted to suit the comfort level of each individual patient without producing discomfort or pain.<br>|
| Experimental: control group<br> | Procedure: routine hospital care without NMES<br>* routine hospital care include all the routine intervention done for post partum women with AKI including fluid resuscitation, diuretics, hemodialysis<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| renal function change | serum creatinine level will be assessed and it will show improvement | for 7 days | 
| renal blood flow change | urine output will be assessed and it will show improvement | for 7 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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neuromuscular electrical stimulation, renal function, renal blood flow, Acute kidney injury