Remineralization of Dentine Caries Using Two Remineralizing Agents Which Are Nanosilver Fluoride and Casein phosphopeptides_amorphous Calcium Phosphate

Study Overview
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Brief Summary
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The study is randomized controlled trial ...The null hypothesis suggests that there is no significant difference between nanosilver fluoride and sodium fluoride with Casein phosphopeptides_amorphous calcium phosphate in the remineralization of dental caries.

Detailed Description
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the patients will be randomly assigned to one of three study groups the first group is nanosilver fluoride,the second is casein phosphopeptides_amorphous calcium phosphate and the third is sodium fluoride as positive control..the three material will be applied in single application with no repetition ..follow up after one and three month ..the patient should have at least one carious lesion(ICDASII code 5)

Official Title
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Remineralization of Dentine Caries Using Nanosilver Fluoride and Casein Phosphopeptides-amorphous Calcium Phosphate (A Randomized Clinical Trial)

Conditions
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Dental Caries

Intervention / Treatment
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* Other: Nanosilver fluoride
* Other: Sodium fluoride with casein phosphopeptides amorphous calcium phosphate
* Other: Sodium fluoride varnish


Participation Criteria
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Eligibility Criteria
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Clinical diagnosis of carious lesion participants should be free of any systemic diseases. Exclusion Criteria: sensitivity to Silver or other heavy-metal ions or any milk-related allergies and medical conditions involving the kidneys. The tooth was excluded if it had pulp exposure, abscess/fistula, sensitivity to percussion

Ages Eligible for Study
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Minimum Age: 6 Years
Maximum Age: 12 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Nanosilver fluoride group<br>Nanosilver fluoride will be applied on carious lesion | Other: Nanosilver fluoride<br>* Nanosilver fluoride will be applied to the affected tooth in single application and then follow up after one and three months<br>|
| Active Comparator: Sodium fluoride with casein phosphopeptides_Amorphous calcium phosphate group<br>Sodium fluoride with casein phosphopeptides_Amorphous calcium phosphate will be applied on carios lesion | Other: Sodium fluoride with casein phosphopeptides amorphous calcium phosphate<br>* Sodium fluoride with casein phosphopeptides amorphous calcium phosphatewill be applied to the affected tooth in single application and then follow up after one and three months<br>|
| Active Comparator: Sodium fluoride varnish group<br>Sodium fluoride varnish will be applied on carios lesion | Other: Sodium fluoride varnish<br>* Sodium fluoride varnish will be applied to the affected tooth in single application and then follow up after one and three months<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The incidence of patient with arrested dental caries using international caries detection and assessment system II(ICDAS II) | The measure will be done using international caries detection and assessment system II (ICDAS II) criteria for diagnosing active and arrested caries by blunt probe. | Change in the state of dental caries after one and 3 months after topical application of nanosilver fluoride and sodium fluoride with casein phosphopeptides amorphous calcium phosphate | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Dental caries remineralization, Nanosilver fluoride