Evaluation of the Containment Impact Linked to the Covid-19 Pandemic in a Population of Parkinson Patients

Study Overview
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Brief Summary
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The consequences of COVID-19 in these already fragile patients should be evaluated. It will be important to appreciate the confinement consequences imposed on the patient on the course and impact of the disease. These consequences can be assessed by the end of confinement and 6 months after the latter is lifted.

Detailed Description
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Adaptation capacities are necessary to cope with the brutal and drastic changes imposed by the pandemic and its consequences. In Parkinson's disease, where there are routine situations with difficulties adjusting to newness, patients in the current situation may be particularly affected and present anxiety due to great difficulties in adaptation. The repercussions in terms of symptoms (motor and non-motor) of the disease could be very significant. In this population already widely exposed to anxio-depressive symptoms (depression being a common symptom of Parkinson's disease, affecting up to 30 to 40% of patients outside of crisis periods), we can expect a risk increased psychiatric decompensation. The psychiatric consequences could not be limited to the current period but also concern long-term patients, in particular if there is decompensation of other symptoms of the disease (motors, complications linked to treatment, etc.). The consequences of COVID-19 in these already fragile patients should be evaluated. It will be important to appreciate the confinement consequences imposed on the patient on the course and impact of the disease. These consequences can be assessed by the end of confinement and 6 months after the latter is lifted. This is an observational, French multicenter study, of an uncontrolled cohort of parkinsonian patients followed by doctors from Parkinson Expert Centers in hospitals.

Official Title
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Evaluation of the Containment Impact Linked to the Covid-19 Pandemic in a Population of Parkinson Patients

Conditions
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Parkinson Disease, COVID

Intervention / Treatment
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* Other: Questionnaire and interview


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient followed by a doctor from the Parkinson Expert Center of the Toulouse University Hospital, Lille, Paris, Rouen, Nimes, Reims, Besancon, Marseille And with idiopathic Parkinson's disease Patients hospitalized or in consultation between 16/03/2020 and 16/05/2020. Exclusion Criteria: Atypical parkinsonian syndrome Patient subject to a legal protection order (tutorship) Patient not wishing to answer questions
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| parkinsonian patients<br>Cohort of parkinsonian patients followed by doctors from the Parkinson Expert Centers in teaching hospitals. | Other: Questionnaire and interview<br>* The questionnaires are Parkinson Disease Questionnaire-8 Items (PDQ-8) Visual Analog Scale (VAS) is visual analog scale visual numeric from 0 to 100, Neuropsychiatric Inventory-Questionnaire-Reduced (NPI-R) and Clinical Global Impression-Impairment (CGI-I).<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Impact of containment related to the Covid-19 pandemic. | To compare quality of life using Parkinson Disease Questionnaire-8 Items (PDQ-8 ), during the period of confinement linked to the Covid-19 pandemic and 6 months after the end of the pandemic in patients with idiopathic Parkinson's disease. The minimum value is never and maximum value is always | 6 months after the end of the pandemic | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Conditions of containment during the Covid-19 pandemic. | Describe in a cohort of Parkinson's patients the conditions of confinement during the confinement period linked to the Covid-19 pandemic such as lifestyle (patient living alone, patient living with a caregiver, patient living in nursing home) and continuing paramedical care (physiotherapist, speech therapist), thanks to a psychosocial assessment | Day 1 | 
| The number of patients infected or possibly infected with Covid-19 | Infected patients will be defined as having had a positive polymerase chain reaction (PCR) or compatible chest scanner. Patients potentially infected: patients who presented symptoms during the period which could suggest an infection by the Covid-19 virus: cough, fever and dyspnea | 6 months after the end of the pandemic | 
| Symptoms modifications | Patients will be asked to list the 3 main symptoms that have changed during the confinement period | 6 months after the end of the pandemic | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Parkinson Disease,, COVID-19, Confinement