Comparison Between Coolprep and Picolyte for Bowel Cleansing

Study Overview
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Brief Summary
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The investigators will compare with PEG+ascorbic acid and picosulfate+magnesium citrate about bowel preparation, patient's satisfaction, side effects to identify effectiveness of new bowel preparation drug.

Detailed Description
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The investigators can find easily colon cancer and poly by colonoscopy, but bowel preparation is very important to find the lesion. Desirable bowel preparation drug must be clearly removed stool, effective on colonoscopic finding and pathologic finding, quickly administrated agent and eliminated stool, comfort for patient, and less side effects. PEG is very safe osmotic laxative. New agent(coolprep) which add ascorbic acid is less salty and less volume. Picosulfate+magnesium citrate(picolyte) taste orange, can be easily prepared bowel for colonoscopy by good taste and small volume. Magnesium with citrate acts like osmotic agent, picosulfate acts irritant agent. The investigators will compare with PEG+ascorbic acid and picosulfate+magnesium citrate about bowel preparation, patient's satisfaction, side effects to identify effectiveness of new bowel preparation drug.

Official Title
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A Randomised Controlled Trial of a 2 Litre Polyethylene Glycol Solution + Ascorbic Acid Versus Sodium Picosulphate + Magnesium Citrate Solution for Bowel Cleansing Prior to Colonoscopy

Conditions
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Stasis; Colon

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age : over 19 years Who will be done colonoscopy Who accepted informed consent Exclusion Criteria: Age : over 80 years Electrolyte imbalance Liver function test abnormality, ascites(over 2 times, >Child class B) ARF or CRF(GFS<30) Recent MI(< 6months) or Unstable angina pectoris Congestive heart failure(NYHA > 2) Inflammatory bowel disease Abdominal minor surgery

Ages Eligible for Study
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Minimum Age: 19 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Coolprep<br>A total of 2L A : NaCl 5.382g KCl 2.03g Sodium sulfate 15g Polyethylene glycol 3350 200.0g B : Ascorbic acid 9.4g Sodium ascorbate 11.8g | |
| Picolyte<br>Sodium picosulfate 30.0mg Magnesium citrate 10.5g + 36.0g | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ottawa scale | * Ottawa scale Individual evaluation of right, mid, and left colon: No liquid - 0 Minimal liquid, no suctioning required - 1 Suction required to see mucosa - 2 Wash and suction - 3 Solid stool,not washable - 4 Evaluation of the entire colon: Overall quantity of fluid 0-2 minimal -0 moderate - 1 Large - 2 * Aronchick score scale Minimal liquid, visible more than 95% of colon mucosa - excellent Clear liquid covered 5 25% of mucosa, visible more than 90% of colon mucosa - good Solid stool, washable, visible more than 90% of colon mucosa - Fair Solid stool, not washable, visible less than 90% of colon mucosa not washable - Poor Bowel preparation is needed - Inadequate | Ottawa scale will be checked at the end of the colonoscopy. Participants won't be followed up because of this study. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patient satisfaction | Taste, Comfort | Questionnaires related with satisfaction and side effects will be written just befor colonoscopy. Participants won't be followed up because of this study. | 
| Symptoms related with bowel preparation | Nausea, Vomiting, Abdominal discomfort, Abdominal distension, Headache, Dizziness, Numbness | Questionnaires related with side effects will be written just befor colonoscopy. Participants won't be followed up because of this study. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Bowel preparation, PEG with ascorbic acid, Picosulfate