Impact of Intermittent Hypoxia on the Function of the Phagocytes

Study Overview
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Brief Summary
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Patients with treatment-naive obstructive sleep apnea (OSA) who need continuous positive airway pressure (CPAP) therapy on clinical basis are included as well as healthy controls without OSA. 15 cc peripheral venous blood is drawn on the date of diagnosis of OSA and 3-6 months after CPAP therapy. Granulocytes are harvested and tested for its function, such as phagocytosis, reactive oxygen species (ROS) production and bacteria-killing ability.

Detailed Description
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Patients with treatment-naive obstructive sleep apnea (OSA) who need continuous positive airway pressure (CPAP) therapy on clinical basis are included. Healthy controls without OSA are enrolled, too. 15 cc peripheral venous blood is drawn on the date of diagnosis of OSA and 3-6 months after CPAP therapy (not given to controls). Granulocytes are harvested and tested for its function, such as phagocytosis, reactive oxygen species (ROS) production and bacteria-killing ability.

Official Title
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Impact of Intermittent Hypoxia on Phagocytosis and Sepsis Outcomes: the Potential Role of Statin (Part III: Human Study in 2018-2019)

Conditions
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Obstructive Sleep Apnea of Adult

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: <OSA group> 1. Patients with treatment-naive obstructive sleep apnea (OSA) who need continuous positive airway pressure (CPAP) therapy on clinical basis 2. aged 20 years or older 3. Apnea-hypopnea index (AHI) at least 15/hour 4. Willing to participate this study <Control group> Healthy controls without OSA aged 20 years or older AHI less than 5/hour Exclusion Criteria: <OSA group> OSA patients who do not need continuous positive airway pressure (CPAP) therapy OSA Patients have ever received CPAP or other treatment aged less than 20 years AHI at least 15/hour Not willing to participate this study <Control group> 1. Apnea-hypopnea index (AHI) equals to or more than 5/hour 2. aged less than 20 years 3. Not willing to participate this study

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Obstructive sleep apnea<br>Patients with treatment-naive obstructive sleep apnea (OSA) who need continuous positive airway pressure (CPAP) therapy on clinical basis | |
| Control<br>Healthy controls without OSA | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Granuolocyte function | Granuolocyte function, such as such as phagocytosis, reactive oxygen species (ROS) production and bacteria-killing ability. | On enrollment | 
| Granuolocyte function | Granuolocyte function, such as such as phagocytosis, reactive oxygen species (ROS) production and bacteria-killing ability. | 3-month | 
| Granuolocyte function | Granuolocyte function, such as such as phagocytosis, reactive oxygen species (ROS) | 6-month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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obstructive sleep apnea, intermittent hypoxia, granulocyte function, continuous positive airway pressure (CPAP) therapy