Effects of Sage Extracts on Cognitive Function During Aerobic Exercise

Study Overview
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Brief Summary
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Extracts of sage have been reported to interact with central nervous system (CNS) mechanisms relevant to cognitive performance but, to date, no trial has clearly demonstrated the possible effects in healthy individuals in fatiguing conditions. The current study investigates the effects of this supplementation in healthy males and females versus placebo on cognition, heart rate and perceived exertion, during a fatiguing cycling exercise.

Detailed Description
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Healthy males and females will be tested in fresh and fatiguing conditions to mimic individuals at the beginning or during a competition where cognitive function are important for decision making for example. Tests will be conducted during the warm-up (fresh), during fatiguing situations (during two consecutive 10-minutes pedaling exercises) and during recovery. Tests will include a reverse digit memory test (from 3 to 7 digits), a stroop test, a simple reaction time test. Moreover, heart rate and rating of perceived exertion will be quantified.

Official Title
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Effects of Sage Extracts on Cognitive Function During Aerobic Exercise in Healthy Individuals

Conditions
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Healthy

Intervention / Treatment
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* Dietary Supplement: Sage extracts Cognivia
* Dietary Supplement: Placebo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Body mass index lower than 27 and waist size lower than 94 cm physical activity higher than 3 hours a week written informed consent Exclusion Criteria: more than 12 hours training a week asthmatic, smokers or under medicinal drugs dietary supplement, sports drink, special dietary food or functional food, of any kind, liable or presented as liable to enhance physical performances

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Sage extract<br>Two hours before the endurance test, participants were asked to absorb two capsules of sage extracts (600mg each - cognivia™) | Dietary Supplement: Sage extracts Cognivia<br>* Cognivia is composed of 400 mg of aqueous extract from Salvia officinalis and the remaining 200 mg contained 50 µL of Salvia lavandulaefolia essential oil and encapsulated with gum acacia. It will be administrated the the morning before the endurance test (oral administration).<br>|
| Placebo Comparator: placebo<br>Two hours before the endurance test, participants were asked to absorb two capsules of placebo (similar appearance than active comparator). | Dietary Supplement: Placebo<br>* Made with maltodextrin. It will be administrated the the morning before the endurance test (oral administration).<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Memory | Changes in percent number of correct answers during a reverse digit immediate memory test | During the 10-minutes warm-up, immediately after the first 10-minutes fatiguing exercise, after the second 10-minutes fatiguing exercise and after a five minutes recovery period | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Heart rate | Changes in heart rate using a polar belt (in beats per minutes) | At rest, at the end of the 10-minutes warm-up, at the end of the first 10-minutes fatiguing exercise, at the end of the second 10-minutes fatiguing exercise, after 5 minutes of recovery | 
| Rating of perceived exertion | Changes in rating of perceived exertion using a visual analogic scale (1-10) | At rest, at the end of the 10-minutes warm-up, at the end of the first 10-minutes fatiguing exercise, at the end of the second 10-minutes fatiguing exercise, after 5 minutes of recovery | 
| Reaction time | Changes in reaction time between a visual signal and manual action | During the 10-minutes warm-up, immediately after the first 10-minutes fatiguing exercise, after the second 10-minutes fatiguing exercise and after a five minutes recovery period | 
| Stroop performance | Changes in percent number of correct answers during a stroop test | During the 10-minutes warm-up, immediately after the first 10-minutes fatiguing exercise, after the second 10-minutes fatiguing exercise and after a five minutes recovery period | 
| Stroop reaction time | Changes in reaction time during the stroop test | During the 10-minutes warm-up, immediately after the first 10-minutes fatiguing exercise, after the second 10-minutes fatiguing exercise and after a five minutes recovery period | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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cycling, cognition, sage, memory, fatigue