Post-Operative Therapy for Nausea or Vomiting

Study Overview
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Brief Summary
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This is a single site, prospective, randomized controlled study designed to evaluate the impact of acupressure when used as an initial treatment before rescue medications in the treatment of post-operative nausea and/or vomiting at UCD.

Detailed Description
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Each individual will only participate in the post anesthetic care unit starting from when the patient's nurse or anesthesiology team deems that the patient needs treatment for PONV. It ends when the patient is discharged from anesthesiology care. Patients will be asked to score nausea before randomized treatment of acupressure or medication, and to score nausea after treatment.

Official Title
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Optimization of Post-Operative Therapy for Nausea or Vomiting

Conditions
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Nausea, Vomiting

Intervention / Treatment
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* Procedure: Acupressure
* Drug: Ondansetron


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: - Patients scheduled for elective surgery requiring general anesthesia Exclusion Criteria: Age less than 18 years Adults unable to give primary consent Pregnancy Prisoners Unable to access pericardial 6 acupressure point bilaterally post procedure Allergy to Ondansetron

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Acupressure<br>Manual pressure will be applied on the wrists bilaterally. | Procedure: Acupressure<br>* Specifically trained personnel will apply pressure on the wrists bilaterally at the P6 point for up to 3 minutes. The P6 point is located three fingerbreadths from the wrist crease on the volar surface of the arm between the palmaris longus and flexor carpi radialis. In the event of failure in the acupressure group, further treatments will be identical to the control group. Since Ondansetron is the standard Post Anesthetic Care Unit treatment, it will be first line rescue therapy except in the case that the patient has received 8mg in the past 6 hours. If needed, further antiemetic pharmacologic treatments may include, but are not limited to, phenergan, metoclopramide, haloperidol, diphenhydramine or propofol at the clinical discretion of the patient's anesthesiology care team.<br>|
| Active Comparator: Ondansetron<br>Ondansetron (Zofran) is used for the treatment of nausea and vomiting. | Drug: Ondansetron<br>* Ondansetron is a medication that belongs to the drug class known as antiemetic and selective 5-HT3 receptor antagonist. Ondansetron is prescribed for the treatment of nausea and vomiting due to cancer chemotherapy and also used to prevent and treat nausea and vomiting after surgery.<br>* Other names: Zofran;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Nausea Score | Difference in the nausea score before and after treatment. Nausea is scored on a scale from 1 to 10 with 1 being no nausea and 10 being severe nausea with impending vomiting. A greater difference is indicative of a better outcome | Time to discharge from post anesthetic care unit | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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PONV, Nausea, Vomiting, Acupressure