Epidemiology Non-cholera Vibrio Infections

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to identify the epidemiological and clinical characteristics of patients diagnosed with non-cholera Vibrio infection in Western France from 2000 to 2019.

Detailed Description
-----------------
Vibrios are gram-negative, ubiquitous bacteria of the marine flora and are found particularly in warm waters. For example, the incidence is high in Florida and Vibrio infections are now reportable in the United States. Different species of Vibrio are described. A distinction is made between choleric vibrios belonging to serogroups O1 and O139, responsible for cholera epidemics, and non-choleric vibrios. Our study will focus on non-cholera vibrios. Vibrio infections can occur by eating contaminated raw seafood or by exposure of a wound to the marine environment. They occur mainly during the hot summer months. This can be explained on the one hand by higher water temperature and on the other hand by increased beach use. With global warming, it is possible that Vibrio infections may increase in number and location.

Official Title
-----------------
Multicentre Retrospective Study on the Clinical and Epidemiological Characteristics and Therapeutic Management of Non-cholera Vibrio Infections

Conditions
-----------------
Vibrio Infections

Intervention / Treatment
-----------------
* Other: non-cholera Vibrio infection


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: non-cholera Vibrio infection Exclusion Criteria: vibriosis to Vibrio cholerae O1 and O139

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| non-cholera Vibrio infection<br>Patients diagnosed with non-cholera Vibrio infection in Western France from 2000 to 2019 | Other: non-cholera Vibrio infection<br>* Epidemiology of patients diagnosed with non-cholera Vibrio infection<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of Participants With Diagnosed Non-cholerae or Non-O1/O139 Vibrio Infection | A non-cholerae or non-O1/O139 Vibrio infection was defined by a biological sample (blood, superficial sample, deep sample, and ear sample) positive to a Vibrio species other than Vibrio cholerae O1-O139. | Up to 20 years, from 2000-2019 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of Patients Per Clinical History | Clinical history: diabetes, heart failure, hepatopathy, neoplasia, alcohol use disorder, Immunosuppressive drug, Pre-existing wound, Digestive surgery, Hemopathy, Kidney Disease | at inclusion | 
| Number of Participants Associated With Environmental Factors | environmental factors : seafood consumption, bathing/water activity, Injury in the aquatic environment, Walk to the beach, Handling of seafood products, returning from a trip abroad | at inclusion | 
| Number of Participants Per Identified Species | Species: Vibrio alginolyticus, Vibrio cholerae Non-O1/Non-O139 Non toxinogenic, Vibrio parahaemolyticus, Vibrio vulnificus, Vibrio sp or other | at inclusion | 
| Number of Participants by Month of the Years |  | at inclusion | 
| Number of Participants Treated by Antibiotics |  | through study completion, an average of 1 month | 
| Number of Participants Per Outcome | outcome :cure, cure with amputation, and deceased due to the infection | through study completion, an average of 1 month |