Observational Prospective Study of the Predicted Value of Immature Thrombocytes Counts in Three Different Groups of Critically Ill Patients

Study Overview
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Brief Summary
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Immature Platelet Fraction (IPF) is a new value in CBC blood tests Recent Studies showed that this value may be another prognostic factor in critically ill patients such as those admitted to ICU, or those with neutropenic Fever. The purpose of the study is to check if the IPF may be used as a prognostic Factor in these patients

Detailed Description
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In this study we have 3 groups of patients Patients admitted to ICU Patients admitted with neutropenic fever Patients admitted with hip fractures it is a prospective study, not interventional, we'll take blood samples of these patients including CBC count eith IPF and other inflammation markers such as CRP and we'll compare CRP to IPF in addition to clinical follow-up of the patient till discharge. At the end of this study we'll compare the efficacy of IPF as a prognostic Factor in these patients

Conditions
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Critically Ill Patients, Neutropenic Fever Patients, Patients With Hip Fractures

Intervention / Treatment
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* Other: Immature Platelet Fraction


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: - Admission to hospital blood sample is taken between 24:00 pm till 15:00 pm Exclusion Criteria: blood sample is taken after 15:00 pm in the first day of admission during the week blood sample is taken on weekend: thursday 15:00 pm till saturday 24:00 pm

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Critically ill patients admitted to ICU<br>those patients who are admitted to ICU with multiorgan failure/injury | Other: Immature Platelet Fraction<br> <br> |
| Neutropinc Fever patients<br>admitted to ER, haemato-oncology or oncology | Other: Immature Platelet Fraction<br> <br> |
| Patients of Hip's Fracture<br>admitted to orthopedic departement | Other: Immature Platelet Fraction<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time to recovery from sepsis or time to death | the primary outcome is the result of the patient's admission on which data analysis will be based | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Predicting value of IPF for prognosis | after the analysis of the data we'll may ba able to assess the predicting value of the IPF in predicting severity of infection and prediciting prognosis of infection in the three groups described | baeline 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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IPF Immature platelet fraction, ICU neutropenic fever, hip fracture, critically ill