linjc16/ctgov huggingface dataset:
Management of Pain Associated With Failed Back Surgery Syndrome

Study Overview
=================
Brief Summary
-----------------
Neuropathic pain is a common complication following different types of spine surgery making negative impact on health, along with life style changes and management, many neurologist prescribed either Pregabalin or Gabapentin to manage this condition with overall good results. our study aims to evaluate the efficacy of Pregabalin and Gabapentin in the management of this condition and to compare between them

Official Title
-----------------
Pregabalin Versus Gabapentin Efficacy in the Management of Neuropathic Pain Associated With Failed Back Surgery Syndrome

Conditions
-----------------
Failed Back Surgery Syndrome

Intervention / Treatment
-----------------
* Drug: Pregabalin 75mg
* Drug: Gabapentin 300mg


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with Previous spine surgery and subsequent chronic back pain Exclusion Criteria: Patients with connective tissue diseases Patients with psychiatric illnesses

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Pregabalin<br>A dose of 75 mg of Pregabalin twice daily for one month will be prescribed to each patient enrolled this study arm | Drug: Pregabalin 75mg<br>* Each patient complaining of pain associated with spine surgery who is randomly enrolled this arm of the study and start the specific medication of the arm with the recommended dose and duration for a period of one month, patient will be followed regularly regarding compliance to doses and to register any side effect.<br>|
| Active Comparator: Gabapentin<br>A dose of 300 mg of Gabapentin twice daily for one month will be prescribed to each patient enrolled this study arm | Drug: Gabapentin 300mg<br>* Each patient complaining of pain associated with spine surgery who is randomly enrolled this arm of the study and start the specific medication of the arm with the recommended dose and duration for a period of one month, patient will be followed regularly regarding compliance to doses and to register any side effect.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Efficacy in Neuropathic pain management | Visual analogue scale pain, minimum score is 0, maximum is 10, the higher ther score the more severe pain | outcome will be assessed one month after the initiation of medication | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Pregabalin, Gabapentin, neuropathic pain, spine surgery
Gene Expression Profiles in Patients With Metastatic Pancreatic Cancer

Study Overview
=================
Brief Summary
-----------------
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer. PURPOSE: This laboratory study uses gene expression profiling to compare primary tumor cells with metastatic tumor cells in patients with metastatic pancreatic cancer.

Detailed Description
-----------------
OBJECTIVES: Compare the gene expression profiles of pancreatic cancer cells from the primary and metastatic sites in patients with metastatic pancreatic cancer. Characterize the function of the differentially upregulated and downregulated genes identified by comparing the gene expression profiles of primary and metastatic cells in these patients. OUTLINE: Fresh biopsy samples are collected for gene expression profiling and other biomarker/laboratory analyses. PROJECTED ACCRUAL: A total of 10 patients will be accrued for this study.

Official Title
-----------------
Gene Expression Profiles in Primary and Metastatic Pancreatic Cancer

Conditions
-----------------
Pancreatic Cancer

Intervention / Treatment
-----------------
* Genetic: microarray analysis
* Other: laboratory biomarker analysis


Participation Criteria
=================
Eligibility Criteria
-----------------
DISEASE CHARACTERISTICS: Diagnosis of pancreatic adenocarcinoma of exocrine origin Metastatic disease Fresh biopsy material available from primary site of disease and a metastatic focus, including liver, peritoneum, or lymph node PATIENT CHARACTERISTICS: Not specified PRIOR CONCURRENT THERAPY: No prior chemotherapy or radiotherapy for pancreatic cancer
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Genetic: microarray analysis|nan|
|Other: laboratory biomarker analysis|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Gene expression profiles |  | at time of biopsy | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
recurrent pancreatic cancer, stage IV pancreatic cancer
Prevalence Assessment and Characterization of Psychological Disorders Associated With Hypobetalipoproteinemia

Study Overview
=================
Brief Summary
-----------------
Familial hypobetalipoproteinemia (FHBL, OMIM # 1707730) is a genetic disorder heterozygotic of LDL-C metabolism. Clinical manifestation range from asymptomatic patients to metabolic (fatty liver, diabetes) or psychiatric disorders still unrecognized. HYPOPSY research, aims to evaluate prevalence of hypobetalipoproteinemia, and to characterize specific related psychiatric disorders.

Detailed Description
-----------------
Familial hypobetalipoproteinemia (FHBL, OMIM # 1707730) is a genetic disorder heterozygotic of LDL-C metabolism (Low Density Lipoprotein - Cholesterol) whose incidence is measured from 1: 500 to 1: 1000. These heterozygous individuals may be asymptomatic or present some clinical (fatty liver, diabetes) or psychiatric manifestations still unrecognized. Moreover, these individuals have mostly a longevity syndrome and cardiovascular protection. The FHBL is often due to mutations of the APOB (APOlipoprotein B), major component of LDL, VLDL (Very Low Density Lipoprotein) and chylomicrons, and in some cases, loss-of-function mutations of the serine protease PCSK9, endogenous inhibitor of the LDL receptor. HYPOPSY research, aims to evaluate, in a population with psychiatric disorders, the prevalence of hypobetalipoproteinemia, and to characterize specific related psychiatric disorders.

Official Title
-----------------
Prevalence Assessment and Characterization of Psychological Disorders Associated With Hypobetalipoproteinemia

Conditions
-----------------
Hypobetalipoproteinemia

Intervention / Treatment
-----------------
* Other: Hypobetalipoproteinemia diagnosis (LDL-C ≤ 50 mg/dL without hypolipidemic treatment)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients admitted in mental Disorders Unit in Nantes University Hospital Exclusion Criteria: Minor patient

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 100 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Hypobetalipoproteinemia diagnosis (LDL-C ≤ 50 mg/dL without hypolipidemic treatment)|LDL-C dosage.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Frequency of hypobetalipoproteinemia (LDL-C ≤ 50 mg/dL without hypolipidemic treatment) among psychiatric patients managed in Nantes University Hospital | Dosage of LDL-C | Inclusion. |
Repeatability of Electroretinogram and Visual Evoked Potential

Study Overview
=================
Brief Summary
-----------------
To assess repeatability of electroretinogram and visual evoked potential in clinical practice

Detailed Description
-----------------
To assess repeatability of electroretinogram in evaluation of retinal function and visual evoked potential in evaluation of visual pathway in clinical practice.

Official Title
-----------------
Repeatability of Electroretinogram and Visual Evoked Potential in Clinical Practice

Conditions
-----------------
Retinal Disease, Visual Impairment, Vision Disorders

Intervention / Treatment
-----------------
* Diagnostic Test: Electroretinogram (ERG)
* Diagnostic Test: Visual evoked potential (VEP)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Normal subjects visit banha university hospital seeking regular checkup and subjects asked for ERG and VEP as a pre-occupational examination. Exclusion Criteria: Patients previously diagnosed with any retinal disease or visual pathway disease that may affect ERG and VEP tests.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Electroretinogram test (ERG)<br>ERG test will be done for each subject twice and compare the results to assess repeatability of the test. | Diagnostic Test: Electroretinogram (ERG)<br>* Applying electrodes to assess retinal function<br>|
| Active Comparator: Visual evoked potential test (VEP)<br>VEP test will be done for each subject twice and compare the results to assess repeatability of the test. | Diagnostic Test: Visual evoked potential (VEP)<br>* Applying electrodes to assess visual pathway function<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Repeatability of ERG amplitude. | ERG amplitude measured in nano volt (nV). | Changes from baseline measurements and at one week. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Repeatability of ERG latency. | Latency of ERG measured by millisecond (msec). | Changes from baseline measurements and at one week. | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Electroretinogram, Visual evoked potential
Goalsetting in Patients With Chronic Pain: a European Survey

Study Overview
=================
Brief Summary
-----------------
The aim of this survey is to get insight in the individual goals of chronic pain patients according to the ICF framework.

Official Title
-----------------
Goalsetting in Patients With Chronic Pain: a European Survey

Conditions
-----------------
Chronic Pain

Intervention / Treatment
-----------------
* Other: Filling in an online survey regarding goalsettings


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients who are suffering from chronic pain Exclusion Criteria: healthy participants or patients with acute pain
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| patients with chronic pain<br> | Other: Filling in an online survey regarding goalsettings<br>* Patients are asked to fill in an online survey regarding their individual goalsettings.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Individual goalsettings | Individual goals that patients want to achieve with their treatment. | at the moment of filling in the survey (cross-sectional) |
Endovenous Radiofrequency Versus Laser Ablation for the Treatment of Great Saphenous Vein Reflux

Study Overview
=================
Brief Summary
-----------------
our aim is to compare early outcomes following EVL 1320 nm and segmental RF in a randomized study.

Detailed Description
-----------------
Endovenous Radiofrequency versus Laser Ablation for the Treatment of Great Saphenous Vein Reflux

Official Title
-----------------
Prospective, Randomized Study of Endovenous Segmental Radiofrequency Versus 1320 nm Laser Ablation for the Treatment of Great Saphenous Vein Reflux (RVLAb Study)

Conditions
-----------------
Varicose Veins

Intervention / Treatment
-----------------
* Other: radiofrequency


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients between the ages of 18 and 60 years with incompetent GSVs documented on duplex ultrasound (US; B-mode and color Doppler imaging) were eligible Exclusion Criteria: Exclusion criteria consisted of: Current deep vein thrombosis (DVT) Thrombus in the vein of interest Previous GSV treatment Pregnancy Known malignancy Significant arterial disease (ankle : brachial pressure index below 0•8) Use of anticoagulant medication.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Sham Comparator: ClosureFast group<br>Radiofrequency Ablation for the Treatment of Great Saphenous Vein Reflux | Other: radiofrequency<br>* ClosureFAST<br>* Other names: ClosureFAST;|
| Sham Comparator: group 1<br>EVL group Endovenous Laser Ablation for the Treatment of Great Saphenous Vein Reflux | Other: radiofrequency<br>* ClosureFAST<br>* Other names: ClosureFAST;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of Participants with Adverse Events as a Measure of Safety and Tolerability |  | 30 days |
Development of Real-time Image-guided Radiotherapy

Study Overview
=================
Brief Summary
-----------------
The goal is to achieve the maximal radiotherapy tumor dose while sparing the health tissue and critical structures. On-board cone-beam CT (CBCT) scans are routinely acquired prior to dose delivery and matched with simulation CT at the planned treatment positions. Thus, setup or motion errors can be detected and corrected. However, CBCT is not available for situations with gantry collisions such as WBI and TSEB. More importantly, CBCT cannot reveal any irregular respiration or body movement during beam-on time. Thus, it is essential to develop a real-time image system that can detect organ/body motion during beam-on time, and correlate simulation-planning images with prior treatment CBCT images.In this proposed clinical trial, we will cooperate with a 3D camera company (Xigen LLC) to develop novel 4D video imaging techniques and validate the feasibility and accuracy of 4D video image guidance in correlation with 4D CT/CBCT useful for advanced IGRT.

Official Title
-----------------
Development of Real-time Image-guided Radiotherapy

Conditions
-----------------
Breast Cancer, Lung Cancer, Skin Cancer

Intervention / Treatment
-----------------
* Radiation: Image guided radiation therapy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All patients benefit from advanced IGRT can participate to the study except for those emergent and pediatric patients (age <18 years) who require special care or there is no time for the setup the 4D video systems The patient population would be selected according to the technical progress and clinical needs Exclusion Criteria: None

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Radiation: Image guided radiation therapy|Real-time 4D video imaging guidance with combination use of cone-beam computerized tomography (CBCT) useful for daily setup and target motion tracking in advanced image-guided radiotherapy (IGRT).|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Develop real-time 4D video imaging guidance with combination use of cone-beam computerized tomography (CBCT) useful for daily setup and target motion tracking in advanced image-guided radiotherapy (IGRT). | Real time 4-D video imaging in combination with CBCT to detect appropriate delivery of radiotherapy | 12 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To correlate real-time 4D surface images with the internal structures shown in daily XVI volumetric images | Align 4D surface images with internal structures | 12 years |
Endogenous Endophthalmitis in the Inpatient Setting

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine the rate of endogenous endophthalmitis in patients admitted to Stanford Hospital with a systemic infection and positive blood cultures, as this may improve the clinical care of this population of patients.

Detailed Description
-----------------
Some patients admitted to the hospital have blood-borne infections. Occasionally, these blood infections can end up inside the eye and cause an infection inside the eye (called endogenous endophthalmitis). Prior to modern and rapid treatment of systemic infections, the rate of endogenous endophthalmitis was reported to be 37% in 1982. By 1997, the rate was reported to be 2.8%. This study aims to determine the rate of endogenous endophthalmitis at Stanford Hospital in the modern medical era in that our rates may be different as those reported in the literature. This potential difference may be a reflection of treatment protocols and antibiotics currently in use at Stanford Hospital.

Official Title
-----------------
Endogenous Endophthalmitis Rates, Clinical Course, and Outcomes

Conditions
-----------------
Endophthalmitis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria:All patients admitted to Stanford Hospital that have a systemic blood-borne infection and on which an Ophthalmology consult to rule out endogenous endophthalmitis is performed will be included in the study. Exclusion Criteria:None
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Positive intraocular infection |  | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Visual acuity |  | 2 wk |
Dominican Republic Mission Cost Analysis

Study Overview
=================
Brief Summary
-----------------
Expenditures on material supplies and medications constitute the greatest per capita costs for surgical missions. We hypothesized that supply acquisition at nonprofit organization cost would lead to significant cost-savings compared to supply acquisition at US academic institution costs from the provider perspective for hernia repairs and minor procedures during a surgical mission in the Dominican Republic.

Official Title
-----------------
A Material Cost-Minimization Analysis for Hernia Repairs and Minor Procedures During a Surgical Mission in the Dominican Republic

Conditions
-----------------
Hernia, Hydrocele

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients presenting to the Institute of Latin American Concern Center for surgical procedure, previously screened by local healthcare workers. Require hernia surgery, hydrocelectomy, excision of benign cutaneous mass. Exclusion Criteria: Did not require hernia surgery, hydrocelectomy, excision of benign cutaneous mass.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Dominican Republic patients at NPO Outpatient Surgery Center<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Expenditure on material supplies and medications | Using quick response (QR) codes for accurate consumption accounting, non-profit and US academic institution unit costs are associated with each item in an electronic inventory system. Medication doses are recorded and QR codes for consumed items are scanned into a record for each sampled procedure. | within 2 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Hernia repair, Hydrocelectomy, Global Health, Global Disease Burden, Surgical Mission, Dominican Republic, Cost-minimization, Procedural cost, Material cost, Item utilization, Excision of benign cutaneous mass, Minor procedure