Drug-drug Interaction Study Between Edaravone and 2-Aminoethanesulfonic Acid in Compound Edaravone Injection

Study Overview
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Brief Summary
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An experiment to evaluate the drug-drug interaction of formula edaravone and formula 2-aminoethanesulfonic acid in compound edaravone injection.

Official Title
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An Experiment to Evaluate the Drug-drug Interaction of Formula Edaravone and Formula 2-Aminoethanesulfonic Acid in Compound Edaravone Injection

Conditions
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Drug-drug Interaction

Intervention / Treatment
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* Drug: Compound Edaravone Injection
* Drug: Edaravone Injection
* Drug: 2-Aminoethanesulfonic Acid Injection


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age: 18-65 years old (including upper and lower limits); Weight ≥50 kg, body mass index (BMI) between 18-28 kg / m2 (including upper and lower limits); Understand and sign the informed consent voluntarily, and volunteer to participate in this research. Exclusion Criteria: A history of diseases of the heart, liver, lung, kidney, digestive tract, blood, or neuropsychiatric system judged by the investigator as clinically significant; A comprehensive physical examination, neurological examination, laboratory examination, ECG examination, or cognitive assessment indicates that the subject has an abnormality that the researcher has determined to be clinically significant; Have taken any drug within two weeks before the study administration, and the researcher believes that this situation may affect the evaluation results of this study; There is a history of food or drug allergy or allergies that the researcher judges to be clinically significant; Those with positive results of serological examination (HBsAg, anti-HCV, anti-HIV, TP-Ab); A history of alcohol or drug abuse that the investigator believes may affect the evaluation results of this study within one year before the study administration; Cannot quit smoking or drinking during the study period or the carbon monoxide breath test> 7 ppm during the screening period CO breath test, so if the subject's CO breath is> 7ppm, but the urine cotinine test is negative, it means that the CO breath test result may be false positive, the subject can be enrolled; As a subject who has participated in any drug clinical trial within 3 months before the first administration of the study; Those who donated blood or blood products ≥400 mL or 2 units within three months of the study; Do not agree to avoid the use of tobacco, alcohol or caffeinated beverages, or vigorous exercise, or other factors that affect drug absorption, distribution, metabolism, excretion, etc. during the 24 hours before and during the test; Pregnant or lactating women, or those who tested positive for serum HCG before the test administration, or those who were unable or unwilling to take researcher-approved contraception during the study according to the researcher's instructions; Subjects with poor compliance or unable to comply with the relevant provisions of the research protocol due to personal reasons, the investigator judges that the subjects are not suitable to participate in this clinical study.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Interventional Model Description: Three-cycle crossover study
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Compound Edaravone<br>30 mL (containing edaravone 30 mg and 2-aminoethanesulfonic acid 600 mg) | Drug: Compound Edaravone Injection<br>* 30 min intravenous infusion<br>|
| Experimental: Edaravone<br>30 mL (containing edaravone 30 mg) | Drug: Edaravone Injection<br>* 30 min intravenous infusion<br>|
| Experimental: 2-Aminoethanesulfonic Acid<br>30 mL (containing 2-aminoethanesulfonic acid 600 mg) | Drug: 2-Aminoethanesulfonic Acid Injection<br>* 30 min intravenous infusion<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cmax of edaravone with and without coIntravenous with 2-Aminoethanesulfonic Acid |  | 24 hours | 
| AUC0-t of edaravone with and without coIntravenous with 2-Aminoethanesulfonic Acid |  | 24 hours | 
| AUC0-∞ of edaravone with and without coIntravenous with 2-Aminoethanesulfonic Acid |  | 24 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Drug-drug Interaction, Edaravone, 2-Aminoethanesulfonic Acid, Compound Edaravone Injection