Photomotor Reflex to Evaluate the Role of the Non-visual Effects of Light in Neurological, Psychiatric and Ophthalmological Pathologies

Study Overview
=================
Brief Summary
-----------------
The light has visual and non-visual effects on organism and can act on the behavior, the mood, the cognition and the sleep. These effects are mediated by classical retina photoreceptors which allow vision (rods, cones) but also melanopsin cells. The non-visual effects of light seems to be altered in many neurological, psychiatric or ophtalmological conditions but their exact role in the pathogenesis remains poorly understand. The purpose of the study is to increase our knowledge of the non-visual effects of light and establish new therapeutic applications

Official Title
-----------------
Study of the Photomotor Reflex to Evaluate the Role of the Non-visual Effects of Light in Neurological, Psychiatric and Ophthalmological Pathologies

Conditions
-----------------
Sleep Disorders, Neurological Pathologies, Psychiatric Pathologies, Ophthalmological Pathologies

Intervention / Treatment
-----------------
* Other: Specific light exposures


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Man or woman Aged 18 years or older Subject having signed a free and informed consent Subject affiliated to a social protection scheme Arm 1 :Subjects with primary sleep-wake disorder Arm 2 : subjects presenting a neurological pathology with disorder of the controls of the wake and the sleep Arm 3 : subject presenting a psychiatric pathology pathology with disorder of the controls of the wake and the sleep Arm 4 : subject presenting an ophthalmological pathology with possible alteration of the photoreception and / or phototransduction Arm 5 : subjects with photosensitivity with regulation disorder of sleep and wake Arm 6 : healthy subject Exclusion Criteria: Age-Related Macular Degeneration (AMD) and all maculopathies (retinopathies pigmentosa, macular involvement of diabetes) Cataract with significant vision loss <5/10 Chorioretinal neovascularization Subject in exclusion period determined by previous or current study Impossibility to give the subject information enlightened (subject in emergency situation, difficulties of understanding the subject, ...) Subject under the protection of justice Subject under guardianship or curatorship Pregnancy / Breastfeeding

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: primary sleep-wake disorder<br>Subjects with primary sleep-wake disorder | Other: Specific light exposures<br>* Specific light exposures using light in a wide range of intensities or different light/dark regimens<br>|
| Other: neurological pathology<br>subjects presenting a neurological pathology with disorder of the controls of the wake and the sleep | Other: Specific light exposures<br>* Specific light exposures using light in a wide range of intensities or different light/dark regimens<br>|
| Other: psychiatric pathology<br>subject presenting a psychiatric pathology with disorder of the controls of the wake and the sleep | Other: Specific light exposures<br>* Specific light exposures using light in a wide range of intensities or different light/dark regimens<br>|
| Other: ophthalmological pathology<br>subject presenting an ophthalmological pathology with possible alteration of the photoreception and / or phototransduction | Other: Specific light exposures<br>* Specific light exposures using light in a wide range of intensities or different light/dark regimens<br>|
| Other: photosensitivity<br>subjects with photosensitivity with regulation disorder of sleep and wake | Other: Specific light exposures<br>* Specific light exposures using light in a wide range of intensities or different light/dark regimens<br>|
| Other: group control<br>healthy subject | Other: Specific light exposures<br>* Specific light exposures using light in a wide range of intensities or different light/dark regimens<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| PIPR : Post-Illumination Pupil Response | 1 measurement per subject is performed after exposure to monochromatic light exposure | 1 day |