The Effects of Smoking Withdrawal On Resting State Functional Connectivity

Study Overview
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Brief Summary
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The purpose of this study is to see how the brain differs between smoking regularly and after not smoking for 24 hours. The investigators will be using an MRI machine to get the information from adult smokers and non-smokers while they lie in the scanner with their eyes closed. Smokers will be scanned when they have not smoked for 24 hrs and shortly after smoking. It is our hypothesis that brain activity will be altered after not smoking for 24 hours.

Detailed Description
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The broad objective of this proposal is to identify functional neuroanatomical correlates of changes in brain functional connectivity during smoking abstinence. The investigators will measure changes in regional blood oxygenation levels using fMRI while adult smokers and non-smokers lie in the scanner with their eyes closed. Smokers will be scanned when they are abstinent from smoking for 24 hrs and shortly after smoking. Our primary hypothesis is that smoking abstinence will alter resting state brain activity (or resting state functional connectivity; RSFC) across widely distributed neural networks and that high-resolution fMRI will help in resolving the exact nature of such changes. Data will be analyzed using methods developed in our laboratory and applied to other resting state datasets. All of the procedures used in the study are well validated and introduce only minor risk to participants (e.g. blood draw; MRI).

Official Title
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The Effects of Smoking Withdrawal on Resting State Functional Connectivity

Conditions
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Smoking

Intervention / Treatment
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* Behavioral: Abstain from smoking for 24 hours


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Right handed Drug free No known health problems Currently not taking any medication Uninterested in quitting smoking long term Exclusion Criteria: Left handed/ambidextrous Currently taking medication Interested in quitting long term

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: Abstain from smoking for 24 hours|Compare smoking satiation to 24 hour smoking abstinence|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood-oxygen-level-dependent (BOLD) signal | Smokers will be scanned after smoking to satiety. In order to be considered satiated, smokers will have to be regular smokers (smoking daily for at least 2 years). | following smoking cigarette 30 minutes prior to scan | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood-oxygen-level-dependent (BOLD) signal | Smokers will be asked to stop smoking 24 hours prior to the scan without the aid of nicotine replacement therapies. They will resume smoking as usual 24 hours after the scan. | 24 hours abstinence | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Smoker, Non-Smoker, Healthy, Drug free, MRI