Effect of Phosphorus Supplementation on Body Weight

Study Overview
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Brief Summary
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Phosphorus is a mineral that is naturally present in our foods and is required by our bodies for normal function. It has been found that phosphorus supplementation taken before meals has the potential to reduce meal size. However its long term effect has not been measured yet. It is well accepted that changes in body weight require about 3 months. Using body weight as the outcome, which is the ultimate outcome of weight loss approaches, would provide robust information on the role of phosphorus.

Detailed Description
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A double-blind, randomised, placebo-controlled trial of 63 adults aged 18 to 45 years with a body mass index (BMI) of 25 kg/m2 or higher and normal kidney function at the American University of Beirut. Participants were randomly assigned to the placebo or phosphorus group where daily placebo or phosphorus supplements were ingested with three main meals (breakfast, lunch, and dinner) for a period of 12 weeks. Primary outcomes were changes in anthropometric measures, blood metabolites (including lipid profile, glucose, and insulin), and subjective appetite scores.

Official Title
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Premeal Phosphorus Supplementation for Reducing Energy Intake and Body Weight

Conditions
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Body Weight

Intervention / Treatment
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* Dietary Supplement: phosphorus


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: BMI>25 CR>1mg/dl for women; Cr >1.2 mg/dl for men GFR >60ml/min/1.73m2 Exclusion Criteria: BMI<25 presence of any significant medical disease, pregnancy or lactation, regular administration of drugs that affect body weight, and weight loss of 3% or more within 3 months of study entry.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: phosphorus<br>phosphorus ingestion (375mg) with each main meal ( breakfast, lunch, dinner) | Dietary Supplement: phosphorus<br>* phosphorus supplement<br>|
| Placebo Comparator: placebo<br>ingestion of placebo tablets with each meal ( breakfast, lunch, dinner) | Dietary Supplement: phosphorus<br>* phosphorus supplement<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Body Weight |  | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Waist Circumference |  | 3 months | 
| Appetite Score on the Visual Analog Scale |  | 6 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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phosphorus intake