Role of the Chemical Environment in the Pathogenesis of Inflammatory Bowel Disease

Study Overview
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Brief Summary
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Inflammatory Bowel Diseases (IBD) including Crohn's disease and ulcerative colitis are multifactorial diseases leading to chronic inflammation of intestinal mucosa. Their etiology is still unknown. Recently, major advances in the understanding of their pathophysiology have allowed to define them as heterogenic polygenic diseases, occurring in genetically susceptible patients. However, the whole genetic susceptibility does not explain the development of IBD and several data argue in favor of the involvement of environmental factors, which remain to be identified. The aims of this clinical trial are: As main objective: To determine the effects of environmental pollutants on intestinal homeostasis and particularly on inflammatory process and endoplasmic reticulum stress. As secondary objective, to assess in human the genetic susceptibility of intestinal mucosa to environmental chemical compounds (I.e. xenobiotics), its interindividual variability, and its potential involvement in the pathogenesis of IBD.

Official Title
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Role of the Chemical Environment in the Pathogenesis of Inflammatory Bowel Disease

Conditions
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Inflammatory Bowel Diseases

Intervention / Treatment
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* Other: Collect of blood, urines, and intestinal biopsies


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients who are at least 18 years old Has Crohn's disease or ulcerative colitis, diagnosed, confirmed by radiological and / or endoscopic examination within 4 years or Control patient not suffering from inflammatory bowel disease (patient with abdominal pain and / or persistent diarrhea, or patient requiring coloscopy for cancer of the digestive tract diagnosis) Patients requiring coloscopy as part of their medical follow-up Social insured. Exclusion Criteria: Pregnant women Breastfeeding women People in emergency Persons unable to understand, read and / or sign informed consent Patients who recently had an intercurrent episode (eg recent diarrhea ...) Persons deprived of their liberty Persons protected by a legal protection status

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Control patients<br> | Other: Collect of blood, urines, and intestinal biopsies<br> <br> |
| Crohn's disease patients<br> | Other: Collect of blood, urines, and intestinal biopsies<br> <br> |
| Ulcerative colitis patients<br> | Other: Collect of blood, urines, and intestinal biopsies<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of inflammatory response of biopsies to pollutants between the 3 groups of patients. |  | Baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of expression pattern of genes involved in xenobiotics detoxification in intestinal mucosa in between the 3 groups of patients. |  | Baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Environmental risk factors, Xenobiotic detoxification