Spectrum of Bacterial Infections in Rheumatology

Study Overview
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Brief Summary
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Retrospective study of patients with a proved non-tuberculous osteoarticular infection (OAI) diagnosed in a rheumatology department during the years 2010-2020. The objectives are : To describe sites, type of micro-organism, clinical data, origin of infection, therapeutic modalities et outcome To compare OAI of urinary origin with those with another origin

Detailed Description
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This retrospective study will be conducted on medical files. Patients will be mainly selected on : A proved osteoarticular infection (OAI) diagnosed in the department of rheumatology of the René Dubos hospital from 1° January 2010 to 31 December 2020. Adult patients 18 year's old or older Infection proved by positive culture in the osteoarticular site and/or blood (with typical clinical and imaging features) The followed OAI are not included : Infection on prosthetic joint, materiel ; post-operative OAI ; osteomyelitis Brucellosis ; Lyme disease Patients are selected from the codification of the hospitalization ; medical files are reviewed by the investigators. OAI of urinary origin is defined either by the same micro-organism in urine and osteo-articular sample (or blood) or a bacteria in the osteo-articular sample in conjunction with : urologic pathology, recurrent urinary tract infection, urologic surgery, antibiotic therapy. Characteristics of three populations will be compared : - OAI of urinary origin - OAI of another origin (skin, etc) - OAI without known origin Characteristics include : gender, age, risk factors, site of osteo-articular infection, type of micro-organism, type of positive sample(s), blood cultures, urinary cultures, duration of symptoms, site of primary infection and/or type of contamination, biological results, echocardiography, imaging results, type of treatment (medical, surgical), outcome, duration of hospitalization, intensive unit care stay, death at hospital.

Official Title
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Spectrum of Bacterial Infections in Rheumatology and the Role of Urinary Tract Infection

Conditions
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Articular Disease

Intervention / Treatment
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* Other: Groups/Cohortes


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Subject aged 18 years and over at the time of diagnosis Osteoarticular infection (septic arthritis, spondylodiscitis), by a bacterium or a fungus, proven by a bacteriological sample in situ or in the blood by positive blood culture (with an unequivocal clinical, biological and imaging feature), Diagnosed between 01/01/2010 and 12/31/2020 (11 years) Hospitalization in the rheumatology department of CH René Dubos, Pontoise Exclusion Criteria: Bacterial infection due to the following germs: mycobacteria, brucella, Borrelia Early infection on joint prosthesis Peripheral osteomyelitis Osteoarticular infection without bacteriological proof

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Osteoarticular infections<br>Retrospective study on medical file of patients with osteoarticular infections diagnose (date of the positive bacteriological sample) between January 1, 2010 and December 31, 2020 | Other: Groups/Cohortes<br>* Retrospective study on medical file of patients with osteoarticular infections diagnose (date of the positive bacteriological sample) between January 1, 2010 and December 31, 2020<br>* Other names: Osteoarticular infections;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Identification of the spectrum of osteoarticular infections in adult, in a rheumatology department | The purpose of this database is to describe the spectrum of osteoarticular infections in adults, non-tuberculosis germs, in a rheumatology department of a CHG during the 2010s | Through study completion, an average of 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prevalence of urinary origin in osteoarticular infections in adults, compared with other origins | The second purpose of this database is to identify the characteristics of osteo-articular infections of urinary origin | Through study completion, an average of 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Osteoarticular infection, Bacteria, Urinary tract infections