Analgesic Effect of the QLB-3 for Patients Undergoing a Total Hip Surgery

Study Overview
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Brief Summary
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Total hip arthroplasty (THA) is one of the main elective orthopedic surgery. Recent studies have proven that patients undergoing an elective THA who are part of a fast track surgery program including an opioid free anesthesia (OFA) presented a decrease of mortality and a reduced in-hospital length of stay. Based on the anatomical knowledges, the Quadratus Lumborum Block seems to be an interesting locoregional technique for patients undergoing THA. So far, there is no recommanded locoregional aesthesia in this indication. The investigators hypothezised that QLB would give an efficient analgesia in the 24h following a THA. Therefor, the study performed a prospective, randomized, double blind trial in the Nice Universitary hospital of Pasteur 2 and in Arnault Tzanck Institute among all patients who underwent THA, comparing a QLB using ropivacaïne 2mg/ml 20ml vs isotonic saline solution 20 ml.The main end-point is the decrease opiod consumption in the 24h following THA.

Official Title
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Analgesic Efficiency of the Type 3 Quadratum Lumborum Block in Patients Undergoing Total Hip Arthroplasty : a Randomized Double Blinded Trial

Conditions
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Total Hip Arthroplasty

Intervention / Treatment
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* Drug: Ropivacaine injection
* Other: NACL


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: • All adult patients with unilateral programmed total hip prosthesis surgery are included in the absence of inclusion criteria. Obligation for all patients to be affiliated with social security Patient Informed Consent Signature Exclusion Criteria: chronic opiod consumption pregnancy mental disorder that prevents the usage of the numeric analog scale Contra indications of the realization of QLB Local infection Allergic to the local anesthesia Hemostasis disorder Incapacity of giving the consent : individuals under guardianship by court order, or under judicial protection

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Drug Ropivacaïne 2 mg/ml<br>Realization of the quadratum lumborum block type 3, ultrasounds' guided by the injection of 20 ml of ropivacaïne 2 mg/ml | Drug: Ropivacaine injection<br>* Realization of the quadratum lumborum block type 3, ultrasounds' guided by the injection of 20 ml of ropivacaïne 2 mg/ml<br>|
| Placebo Comparator: NACL<br>Realization of the quadratum lumborum block type 3, ultrasounds' guided by the injection of 20 ml of NACL | Other: NACL<br>* Realization of the quadratum lumborum block type 3, ultrasounds' guided by the injection of 20 ml of NACL<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Opoïd consumption | The main end point of this study is the decrease of opiod consumption in the 24h following THA. | At 24 Hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| morphine equivalent dose | following surgery at rest and in motion | At 48 Hours |