New Prognostic Kidney Function Markers in Emergency Patients New Markers of Kidney Function in ED Patients

Study Overview
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Brief Summary
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NephroCheck is measuring the concentration of a certain protein combination in the urine of patients. In elevated values there is a probability of renal failure (already proven in intensive care patients). The investigators would like to investigate whether the investigators can predict renal failure in patients receiving contrast enhanced CT's in the emergency department. That would lead to an earlier nephrologist consult in those patients.

Detailed Description
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The use of contrast agents can - especially in already in impaired renal function - lead to a decline in real function. The contrast enhanced CT is especially in emergency patients an important diagnostic tool for example in the detection of pulmonary embolism or mesenteric ischemia. Creatinine has been used as a marker for real function so far. But the investigators all know that creatinine is not a perfect marker especially as it is influenced by age, sex, weight and muscle mass. Especially in the diagnosis of acute renal failure creatinine does not allow and recent change in the kidney function. This prospective, unicentric study should therefore investigate two new markers in emergency patients who need an emergency contrast enhanced CT to early predict pending kidney function decline.

Official Title
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New Prognostic Kidney Function Markers in Emergency Patients

Conditions
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Acute Kidney Injury, Contrast Media

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients in the emergency department who have the indication for contrast enhanced CT and a predicted hospital admission time of 48 hours or longer. Exclusion Criteria: children, pregnant women dialysis patients with kidney transplants patients on steroids or further immunocompromised

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| normal creatinine<br>pts receiving an iv-contrast enhanced CT with normal baseline renal function | |
| elevated creatinine<br>pts receiving an iv-contrast enhanced CT with abnormal baseline renal function | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Renal function | renal function at discharge from hospital (creatinine and BUN measured at day of discharge) | participants will be followed for the duration of hospital stay, an expected average of 7 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Requirement for dialysis | dialysis required throughout hospital stay | participants will be followed for the duration of hospital stay, an expected average of 7 days | 
| Admission to ICU | admission to ICU required throughout hospital stay | participants will be followed for the duration of hospital stay, an expected average of 7 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Emergency Medicine, diagnosis