Effect of Physical Activity an Stress in Children

Study Overview
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Brief Summary
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The objective of the study is to evaluate the impact of physical activity in obese and nonobese prepubertal children on: biological stress responses during a psychosocial stress test snacking and feeling of hunger in response to the same psychosocial stress test the moderating factor of attachment on the biological stress responses and on snacking Children will be investigated on one study day during 3.5 hours.

Detailed Description
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Hypotheses In this study, 3 primary hypotheses will be tested. Moderate physical activity during 25 min in children decreases the cortisol levels in response to the Trier Social Stress Test TSST-C (for children). Moderate physical activity during 25 min in children decreases the snacking (calorie consumption when corrected for expenditure and switch in quality of food intake) in response to the Trier Social Stress Test TSST-C (for children). A secure attachment will be a moderating factor for the general increase in cortisol and the snacking in response to the psychosocial stress test (Trier Social Stress Test TSST-C). Secondary objectives: To test if the impact of physical activity on stress responses and snacking differs between obese and non-obese children To test the impact of physical activity on the cardiovascular stress reactivity (blood pressure, heart rate) and the perceived stress (scale) in response to the Trier Social Stress Test TSST-C? To test if the stress reactivity and its modulation by physical activity is different in anxious and in impulsives/labile children To test if serious life events and parental worries and parental educational style influence the stress reactivity

Official Title
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Effect of Physical Activity an Stress in Children

Conditions
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Snacking, Obesity, Children, Physical Activity, Stress

Intervention / Treatment
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* Behavioral: Acute physical activity intervention
* Behavioral: placebo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 7-10 year old children Exclusion Criteria: Severe illness Medications interfering with study

Ages Eligible for Study
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Minimum Age: 7 Years
Maximum Age: 10 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Acute physical activity intervention<br>25 min of moderate physical activity | Behavioral: Acute physical activity intervention<br>* 25 min of physical activity. The placebo arm will have 25 min of reading.<br>|
| Placebo Comparator: Placebo<br>25 min of reading (instead of physical activity) | Behavioral: placebo<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in salivary Cortisol and maximal levels of salivary cortisol in response to the TSST stress test over 2 hours |  | 9 months | 
| Snacking (Caloric intake, corrected for energy expenditure) | Measure of caloric intake and measure of choice of high-caloric vs low-caloric food snacking after the TSST stress test | 9 months | 
| Moderator effect of attachment (4 different attachment categories), i.e. children with a secure attachment will have lower rises in cortisol compared with children in the other 3 attachment categories | Cortisol levels after the TSST stress test will be lower in children with secure attachment compared to detached, disorganized or preoccupied children (i.e. the 3 other attachment categories). | 9 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Moderator effect of obesity (WHO criteria) |  | 9 months | 
| Cardiovascular reactivity (changes and maximal levels of blood pressure, heart rate) |  | 9 months | 
| Perceived stress (stress scale from 1-7) |  | 9 months | 
| Moderator role of serious life events and parental worries |  | 9 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Obesity, Children, Physical activity, Stress, Snacking