Clinical Values of Automated Electronic Alert for Acute Kidney Injury

Study Overview
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Brief Summary
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Acute kidney injury (AKI) is common, serious and expensive.It is associated with significant mortality, morbidity and increased length of hospital stay.To improve clinical outcomes of AKI by early detection and timely referral to the renal,the investigators developed an electronic alert system which identifies all cases of AKI occurring in patients over 18 years.The system was also designed to collect data on AKI incidence one of the biggest tertiary hospital in China.

Detailed Description
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A prospective, randomly controlled cohort study will be conducted agmong the patients with AKI who are detected by the use of AKI sniffer. The investigators chose to assess all inpatient serum creatinine results using a combination of KDIGO criteria. The investigators randomly divided the patients into two groups: Usual care : patients will receive standard clinical care by the primary physicians AKI alert : an AKI alert will be sent to the the doctor in charge. Our team of kidney experts would give a suggestion if the the doctor in charge issue consultation applications.

Official Title
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Clinical Values of Automated Electronic Alert for Acute Kidney injury-a Prospective ,Randomly Controlled Cohort Study

Conditions
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Acute Kidney Injury

Intervention / Treatment
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* Device: AKI alert


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: adult patients with an Alert for AKI(based on KDIGO guidelines) Exclusion Criteria: patients already on dialysis for AKI at the time of alert patients with End stage renal disease patients <18 years of age patients dissenting from participation according to the Ethics application

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Usual care<br>patients will receive standard clinical care by the doctor in charge. | |
| Experimental: AKI alert<br>an AKI alert will send to the the doctor in charge.Our team of nephrologists would give suggestions if the doctor in charge issue consultation application. | Device: AKI alert<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Adverse events during hospitalization | cardiac shock/ need for intensive care/ cardiopulmonary resuscitation/ cardiac death/ death | from start of AKI to discharge,up to 4 weeks | 
| Incidence of cardiovascular disease and its occurrence time followed up for 1 years | heart failure/ acute coronary syndrome/ readmission/cardiac readmission/ cardiovascular intervention or surgery | One year after discharge | 
| The AKI outcome and its occurrence time followed up for 1 years | AKI recovery/stop renal replacement therapy | One year after discharge | 
| AKI recovery/stop renal replacement therapy | Glomerular filtration rate decreased/ new occurrence proteinuria/ original proteinuria aggravation | from start of AKI to discharge,up to 4 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Proportion of nephrology referral |  | from start of AKI to discharge,up to 4 weeks | 
| Diagnostic rate of AKI at discharge |  | from start of AKI to discharge,up to 4 weeks | 
| Follow-up rate after discharge |  | One year after discharge | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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acute kidney injury, medication alert systems