Glans Size in Hypospadias Compared to Normal

Study Overview
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Brief Summary
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The investigator will collect data on penile and glans size by age, weight and ethnicity in both patients undergoing routine urological surgery and hypospadias surgery.

Detailed Description
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After obtaining informed consent , the investigator will measure stretched penile length and glans size in 3 dimensions (length, width, height) in the office on patients with hypospadias, as well as at the time of operation, after the induction of anesthesia. Patients undergoing hypospadias surgery will be considered study subjects. If the patient was given pre-operative testosterone as part of the current standard of care, this will be noted and the measurements taken at each pre-operative office visit will be recorded. The investigator will also record corrected age, weight in kilograms and ethnicity as identified by the family. Control patients will be those male patients undergoing non-hypospadias urological surgery (hernia repair, orchiopexy, circumcision, re-circumcision) with a normal penis, the investigator will perform a single intra-operative measurement of the same glans and penile variables after induction of anesthesia and prior to the start of their genital surgery. Again, age, weight and ethnicity will be recorded.

Official Title
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Glans Size in Hypospadias Compared to Normal

Conditions
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Hypospadias, Surgery Non Hypospadias

Intervention / Treatment
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* Procedure: Measurement in Office
* Procedure: Measurement in OR


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients undergoing surgery for hypospadias Patients undergoing any urologic surgery other than hypospadias Exclusion Criteria: other penile abnormalities (Hidden penis, penoscrotal wedding/transposition, chordee without hypospadias, penile torsion, etc.) Undergoing other penile procedures (penoplasty, chordee repair, penile detorsion, etc.)
Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Hypospadias<br>Patients with hypospadias | Procedure: Measurement in Office<br>* Penile length and glans size in 3 dimensions<br>Procedure: Measurement in OR<br>* Penile length and glans size in 3 dimensions<br>|
| Control<br>Patients without hypospadias | Procedure: Measurement in OR<br>* Penile length and glans size in 3 dimensions<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Difference in glans size between hypospadias patients and those without hypospadias | The investigator will prospectively collect data on glans size by age, weight and ethnicity in both patients undergoing routine urological surgery and hypospadias surgery | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Difference in penile length between hypospadias patients and those without hypospadias | The investigator will prospectively collect data on penis length by age, weight and ethnicity in both patients undergoing routine urological surgery and hypospadias surgery | 6 months | 
| Track penile and glans growth curves in both cohorts | The investigator will prospectively track penile and glans growth over time to develop longitudinal growth curves in both cohorts | 24 months | 
| Determine the effect of testosterone on penile and glans growth in hypospadias | The investigator will measure the glans size and penile length of patients who receive testosterone for small glans size before and after administration in order to determine the effect of testosterone administration. | 24 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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hypaspadias