Serum Cytokine Levels in Patients With Lumbal Disc Herniation and Effectiveness of Exercise

Study Overview
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Brief Summary
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The aim of the study is to investigate serum cytokine levels and the efficacy of lumbar stabilization exercises in patients with lumbar disc herniation with and without neurological deficits. Patients who applied to Hacettepe University Hospitals Physical Medicine and Rehabilitation Department with low back pain complaints and were referred for treatment will be included in the study.

Detailed Description
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The aim of the study is to investigate serum cytokine levels and the efficacy of lumbar stabilization exercises in patients with lumbar disc herniation with and without neurological deficits. Patients who applied to Hacettepe University Hospitals Physical Medicine and Rehabilitation Department with low back pain complaints and were referred for treatment will be included in the study. Healthy individuals of similar age, height and weight will also be included for references to normal serum cytokine levels. All patients will be evaluated twice, before and 6 weeks after treatment. The treatment program will be applied 3 times a week for 6 weeks under the supervision of a physiotherapist.

Official Title
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Serum Cytokine Levels in Patients With Lumbal Disc Herniation With and Without Neurological Deficits and Effectiveness of Exercise

Conditions
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Low Back Pain

Intervention / Treatment
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* Other: Lumbal stabilization excercises
* Other: Conventional exercises


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria for patients with disc herniation: Diagnosis of disc herniation (protrusion, extrusion, sequestered disc) not an indication for lumbar disc herniation surgery for patients with neurological deficits, loss of strength, decrease in DTRs, loss of sensation and at least one positive SLR test and presence of radicular pain pain intensity of VAS ≥ 3 male and female patients between the ages of 20-55 Inclusion Criteria for heathy people not having low back pain complaints in the past female and male healthy individuals between the ages of 20-55 Exclusion Criteria: systemic or inflammatory disease pregnant or breastfeeding women surgery of lumbar region fracture of lumbar vertebrae lumbar scoliosis medication use for psychiatric disorders tumor allergy neurological disease alcohol-drug use generalized musculoskeletal pain

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 55 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: The stabilization group<br>The stabilization group will perform lumbal stabilization exercises in lying, sitting, standing and on a swisball 3 times a week during 6 weeks. | Other: Lumbal stabilization excercises<br>* The stabilization group will perform lumbal stabilization exercises in lying, sitting, standing and on a swisball 3 times a week during 6 weeks.<br>|
| Experimental: The general exercise group<br>The general exercise group will perform conventional exercises 3 times a week during 6 weeks. | Other: Conventional exercises<br>* The general exercise group will perform conventional exercises 3 times a week during 6 weeks.<br>|
| No Intervention: The control group<br>Individuals in the control group will not be treated. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| inflammatory cytokines | Tnf-alfa , IL-6, IL-4, IL-1β, Beta-endorphins, Anandamide, Arachidonoylgylycerol will be evaluated with ELISA kit. | 6 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Low back pain, Disc herniation, Stabilization exercises, General exercises, Cytokines, Inflammation