Long-Term Follow-up in Patients Included in the Meta-analysis Sleep Apnea Syndrome and Arterial Stiffness

Study Overview
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Brief Summary
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The meta-analysis sleep apnea syndrome and arterial stiffness includes data from 893 patients initially included in 9 studies conducted by the EFCR Department of the CHUGA between 2006 and 2015, presenting a sleep apnea syndrome (SAS) with exploration of their arterial stiffness via the measurement of pulse wave velocity (PWV). Currently, we do not have long-term follow-up data for these patients. The first objective of the PWV Follow-up project is to collect cardiovascular events in these patients through telephone interviews and a structured questionnaire to determine the prevalence of these events. The prevalence of metabolic events, incident cancers and deaths will be also determined as secondary objectives through the same questionnaire. Others secondary objectives are to evaluate the impact of continuous positive airway pressure (CPAP, the reference treatment for OSA) on the occurrence of cardiovascular and metabolic events and incident cancers, as this is still discussed in the literature.

Detailed Description
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The meta-analysis sleep apnea syndrome and arterial stiffness includes data from 893 patients initially included in 9 studies conducted by the EFCR Department of the CHUGA between 2006 and 2015, presenting a sleep apnea syndrome (SAS) with exploration of their arterial stiffness via the measurement of pulse wave velocity (PWV). The 9 studies were referred as : ADISAS (NCT011968), AGIRSASADOM (NCT010902), BPCO (NCT004044), BPCO-SAS (NCT01195064), DIAMETASAS, Aortic Dissection (NCT01068691), INFRASAS (NCT010892), VALSAS (NCT004094), NIV-OHS (NCT006030). The objective of this meta-analysis on individual data was to understand the relationship between the severity of the sleep apnea syndrome (measured by the apnea + hypopnea index) and arterial rigidity at the time of diagnosis of SAS. Currently, we do not have long-term follow-up data for these patients. The first objective of the PWV Follow-up project is to collect cardiovascular events in these patients through telephone interviews and a structured questionnaire to determine the prevalence of these events. The prevalence of metabolic events, incident cancers and deaths will be also determined as secondary objectives through the same questionnaire. Others secondary objectives are to evaluate the impact of continuous positive airway pressure (CPAP, the reference treatment for OSA) on the occurrence of cardiovascular and metabolic events and incident cancers, as this is still discussed in the literature.

Official Title
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Collection of Long-Term Follow-up Medical Events in Patients Included in the Meta-analysis Sleep Apnea Syndrome and Arterial Stiffness

Conditions
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Sleep Apnea

Intervention / Treatment
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* Other: Questionnaire


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: already included in the meta-analysis sleep apnea syndrome and arterial stiffness. Exclusion Criteria: refusal to participate family not reachable and death not identified in the Hospital medical base persons under judicial protection (article L1122-2 of the Public Health Code) and patients under guardianship or curatorship

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients PWV follow-up<br>Patients included in the meta-analysis sleep apnea syndrome and arterial stiffness and contacted by phone for the collection of cardiovascular and metabolic events, incident cancers and deaths, through a structured questionnaire. | Other: Questionnaire<br>* Structured questionnaire to collect cardiovascular and metabolic events, incident cancers and deaths that have occured, as weel as information on CPAP, through telephone interview.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prevalence of cardiovascular events | Prevalence of cardiovascular events during the follow-up of patients included in the meta-analysis sleep apnea syndrome and arterial stiffness, through a structured questionnaire. | up to 15 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prevalence of metabolic events | Prevalence of metabolic events during the follow-up of patients included in the meta-analysis sleep apnea syndrome and arterial stiffness, through a structured questionnaire. | up to 15 years | 
| Prevalence of incident cancers | Prevalence of incident cancers during the follow-up of patients included in the meta-analysis sleep apnea syndrome and arterial stiffness, through a structured questionnaire.. | up to 15 years | 
| Prevalence of deaths | Prevalence of deaths during the follow-up of patients included in the meta-analysis sleep apnea syndrome and arterial stiffness, through a structured questionnaire. | up to 15 years | 
| Effect of CPAP treatment on the cardiovascular events occurrence | Mean CPAP observance (h/night) of patients included in the meta-analysis sleep apnea syndrome and arterial stiffness to determine its impact on the cardiovascular events occurrence. | during 6 months | 
| Effect of CPAP treatment on the metabolic events occurrence | Mean CPAP observance (h/night) of patients included in the meta-analysis sleep apnea syndrome and arterial stiffness to determine its impact on the metabolic events occurrence. | during 6 months | 
| Effect of CPAP treatment on the incident cancers occurrence | Mean CPAP observance (h/night) of patients included in the meta-analysis sleep apnea syndrome and arterial stiffness to determine its impact on the incident cancers occurrence. | during 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Sleep apnea, Follow-up, Cardiovascular event, Metabolic event, incident cancer, Death