Study of Dysarthria, Swallowing Disorders and Respiratory in Parkinson's Disease

Study Overview
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Brief Summary
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The investigators prospectively enrolled 64 early PD patients (less than 3 years after the first symptom) in order to prospectively assess the natural history of non-dopaminergic symptoms.

Detailed Description
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Patients were evaluated at baseline and after 2 years in off drug condition. Clinical, psychological, neuropsychological evaluations, functional respiratory evaluation, swallowing video fluoroscopy, dysarthria, gait and axial disorders.

Official Title
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Prospective Study of Dysarthria, Swallowing Disorders and Respiratory in Parkinson's Disease

Conditions
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Parkinson's Disease

Intervention / Treatment
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* Other: observational study


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: idiopathic parkinson's disease Exclusion Criteria: dementia severe axial gait disorders respiratory or ENT pathology Pregnancy

Ages Eligible for Study
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Minimum Age: 35 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| observational study<br>natural history of non dopaminergic signs | Other: observational study<br>* natural history of non dopaminergic signs<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| dysarthria severity assessed by the BECD scale | BECD (French battery of clinical evaluation of the dysarthria) is a validated scale for qualitative assessment of dysarthria severity in neurological disorders, especially PD | 2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| respiratory insufficiency detection | pulmonary function tests include spirometry with standard spirometer and maximal inspiratory and expiratory flow volume curves . At least 3 reproductible F-V curves are necessary. Values of FCV, FEV, peak expiratory flow, peak inspiratory flow, forced expiratory flow, SNIP were measured 12 hours after last levodopa intake (off drug) | 2 years | 
| swallowing function | 150 mL glass of water test video fluoroscopy of swallow in off drug condition face and profile incidences: qualitative analysis of oral, pharyngeal, aspiration if necessary blindly assessed by 2 ENT experts in PD | 2 years | 
| gait axial function (freezing) | SWS test rhythmic tests for differens imposed frequencies (upper lower limb and facial) kinematic analysis of gait parameters by VICON (oxford metrics) | 2 years | 
| Mattis scale |  | 2 years | 
| LARS scale |  | 2 years | 
| MADRS scale |  | 2 years | 
| PAS scale |  | 2 years | 
| MoCA |  | 2 years | 
| Genetic Polymorphisme | To evaluate of cognitive and profile correlation to the polymorphisms of COMT (catechol-O-methyltransferase: Val158Met COMT) of MAPT H1 / H2 (microtubule associated tau protein) and ApoE (Apolipoprotein-E-ε2, 3, 4 ) | 2 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Idiopathic early, Parkinson's Disease