Effect of Frankincense Extract Gel on Non-Surgical Treatment of Chronic Periodontitis

Study Overview
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Brief Summary
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This study will evaluate the effect of the subgingival application of Frankincense extract gel as an adjunct to scaling and root planning (SRP) in chronic periodontitis.

Detailed Description
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: twenty patients will be randomly selected and equally divided into Group I: will receive SRP only, group II: will receive SRP and Frankincense extract the gel. Subgingival application of Frankincense extract gel will be performed following initial SRP )day 1) and at 7, and 14 days. Clinical measurements included pocket depth (PD), bleeding on probing (BOP), and clinical attachment level (CAL). Real-time PCR was carried out to determine the effect of the treatment on Porphyromonas gingivalis (Pg). Clinical measurements and Plaque samples for PCR were recorded at baseline (before treatment), one, and three months after treatment.

Official Title
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The Adjunctive Effect of Frankincense Extract Gel on Non-Surgical Treatment of Chronic Periodontitis: Clinical and Microbiological Study.

Conditions
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Chronic Periodontitis

Intervention / Treatment
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* Procedure: scaling and root planing
* Procedure: Frankincense extract gel natural herbal product


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: systemically healthy patients were selected patients who had not received any medications for the previous six months that may interfere with periodontal tissue health or healing. Patients should demonstrate their ability to maintain good oral hygiene Exclusion Criteria: Smokers and pregnant patients. Medically compromised patients and systemic conditions precluding periodontal surgery.

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: twenty patients will be randomly be selected and equally divided into Group I: will receive SRP only, group II: will receive SRP and Frankincense extract the gel. Subgingival application of Frankincense extract gel will be performed following initial SRP )day 1) and at 7, and 14 days.
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Placebo group<br>ten patients with sites suffering from mild chronic periodontitis sites will be treated with scaling and root planing (SRP) only | Procedure: scaling and root planing<br>* will receive scaling and root planing only<br>|
| Active Comparator: test group<br>Ten patients with sites suffering from mild chronic periodontitis. sites will be treated with scaling and root planing (SRP) and subgingival application of Frankincense extract gel | Procedure: scaling and root planing<br>* will receive scaling and root planing only<br>Procedure: Frankincense extract gel natural herbal product<br>* will receive Scaling and root planing then. Subgingival application of Frankincense extract gel<br>* Other names: Scaling and root planing;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| probing pocket depth | probing pocket depth will be recorded at baseline, at site that will be treated | baseline | 
| probing pocket depth | probing pocket depth will be recorded at 1 month at the site to be treated | 1 month | 
| probing pocket depth | probing pocket depth will be recorded at 3 month at the site to be treated | 3 month | 
| clinical attachment level | clinical attachment level will be recorded at baseline, | baseline | 
| clinical attachment level | clinical attachment level will be recorded at , 1 month at the site to be treated | 1 month | 
| clinical attachment level | clinical attachment level will be recorded at 3 months at the site to be treated | 3 month | 
| bleeding on probing | bleeding on probingwill be recorded at baseline, at the site to be treated | baseline | 
| bleeding on probing | bleeding on probingwill be recorded at 1, month at the site to be treated | 1 month | 
| bleeding on probing | bleeding on probingwill be recorded at 3 months at the site to be treated | 3 month | 
| PCR for Porphyromonas gingivalis count | PCR for Porphyromonas gingivalis count be recorded at baseline, at the site to be treated | baseline | 
| PCR for Porphyromonas gingivalis count | PCR for Porphyromonas gingivalis count be recorded at 1, and month at the site to be treated | 1 month | 
| PCR for Porphyromonas gingivalis count | PCR for Porphyromonas gingivalis count be recorded at 3 months at the site to be treated | 3 month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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chronic periodontitis., Frankincense, non surgical treatment