Biomarkers in Saliva in Children With Juvenil Idiopathic Arthritis

Study Overview
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Brief Summary
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Purpose and aims This as a pilot study that aims to investigate which inflammatory biomarkers can be found in saliva in children with Juvenile Idiopathic Arthritis (JIA). The hypothesis is that children with JIA will show a different pattern of inflammatory biomarkers in saliva than healthy Children. The null hypothesis is that there are no differences.

Detailed Description
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This is a comparison between 100 children with JIA and 100 healthy children. Saliva will be collected and analyzed with respect to biomarkers. One-hundred consecutive patients with active JIA, as diagnosed by the Department of Pediatric Rheumatology, Astrid Lindgrens Barnsjukhus, Karolinska University Hospital will be included. Inclusion criteria are: age between 7 and 14 years a diagnosis of JIA according to the International League of Associations for rheumatology Exclusion criteria are: current malignancies TMJ surgery or trauma within two years recent intra-articular glucocorticoid injection in TMJ (within 1 month) other conditions or diseases than JIA that may cause orofacial pain. The parents of the patients and/or the patients will give their verbal and written informed consent to participate in the study according to the permission from the regional ethical committee 2011/2:1. The control group of 100 age and sex matched healthy children will be included at Folktandvården Stockholms Län AB. Inclusion criteria are: • age between 7 and 14 years Exclusion criteria are: current malignancies TMJ surgery or trauma within two years recent intra-articular glucocorticoid injection in TMJ (within 1 month) A diagnosis of JIA other conditions or diseases than JIA that may cause orofacial pain. The parents of the patients and/or the patients will give their verbal and written informed consent to participate in the study according to the permission from the regional ethical committee 2011/2:1.

Official Title
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Biomarkers in Saliva in Children With Juvenil Idiopathic Arthritis

Conditions
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Juvenile Idiopathic Arthritis

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 1. A diagnosis of JIA according to the International League of Associations for rheumatology (ILAR) The parents of the patients and/or the patients will give their verbal and written informed consent to participate in the study according to the permission from the regional ethical committee 2011/2:1 Exclusion Criteria: current malignancies TMJ surgery or trauma within two years Recent intra-articular glucocorticoid injection in TMJ (within 1 month) Other conditions or diseases than JIA that may cause orofacial pain. Fore the controllgroup JIA are excluded

Ages Eligible for Study
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Minimum Age: 7 Years
Maximum Age: 14 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Biomarkers in saliva, a comparison between healthy children and children with juvenile idiopathic arthritis. | Saliva sampels will be colleceted and analysed | one day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Juvenile Idiopathic Arthritis, Saliva