Acute Medium Chain Triglycerides (MCT) Intake in Young and Older Participants

Study Overview
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Brief Summary
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Compare plasma metabolites following different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol in young and older participants.

Official Title
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Optimisation of Acute Medium Chain Triglycerides Intake Characteristics on Different Plasma Metabolites in Young and Older Participants

Conditions
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Ketonemia

Intervention / Treatment
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* Dietary Supplement: No MCT intake with breakfast, no lunch
* Dietary Supplement: No MCT intake with lunch, no breakfast
* Dietary Supplement: 10g of Betaquik
* Dietary Supplement: 10g of Betaquik with low-carbs breakfast
* Dietary Supplement: 20g of Betaquik
* Dietary Supplement: 10g of Betaquik with lunch, no breakfast


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 10 health young (20-40 y old) and 10 health older (> 60 y old) participants Men and women Exclusion Criteria: smoking diabetes (fasting glucose >7.0 mmol/l and glycated hemoglobin >6.9%) strenuous aerobic exercise more than three times a week untreated hypertension, dyslipidemia, and abnormal renal, liver, heart or thyroid function under medication known to affect triglycerides and carbohydrates metabolism (i.e. diuretics, beta-blockers, steroids, insulin sensitizing)

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: 10 young and 10 older participants undergoing six separate but identical metabolic visits (interventions)
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: MCT intake in young participants<br>Different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol in young participants. Interventions: No MCT intake with breakfast, no lunch (i.e. CTL) No MCT intake with lunch, no breakfast (i.e CTL inverted) 10g of Betaquik with breakfast, no lunch (i.e BQ10) 20g of Betaquik with breakfast, no lunch (i.e BQ20) 10g of Betaquik with low-carbs breakfast, no lunch (i.e BQ10LC) 10g of Betaquik with lunch, no breakfast (i.e BQ10 inverted) | Dietary Supplement: No MCT intake with breakfast, no lunch<br>* Water given with a regular standardize breakfast and water given at noon without lunch.<br>* Other names: CTL;Dietary Supplement: No MCT intake with lunch, no breakfast<br>* Water given in the beginning of the metabolic study day without breakfast and water given at noon with a regular standardize lunch.<br>* Other names: CTL inverted;Dietary Supplement: 10g of Betaquik<br>* BQ10 given with a regular standardize breakfast and BQ10 given at noon without lunch.<br>* Other names: BQ10;Dietary Supplement: 10g of Betaquik with low-carbs breakfast<br>* BQ10 given with a low-carbs standardize breakfast and BQ10 given at noon without lunch.<br>* Other names: BQ10LC;Dietary Supplement: 20g of Betaquik<br>* BQ20 given with a regular standardize breakfast and BQ20 given at noon without lunch.<br>* Other names: BQ20;Dietary Supplement: 10g of Betaquik with lunch, no breakfast<br>* BQ10 given in the beginning of the metabolic study day without breakfast and BQ10 given at noon with a regular standardize lunch.<br>* Other names: BQ10 inverted;|
| Experimental: MCT intake in older participants<br>Different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol in older participants. Interventions: No MCT intake with breakfast, no lunch (i.e. CTL) No MCT intake with lunch, no breakfast (i.e CTL inverted) 10g of Betaquik with breakfast, no lunch (i.e BQ10) 20g of Betaquik with breakfast, no lunch (i.e BQ20) 10g of Betaquik with low-carbs breakfast, no lunch (i.e BQ10LC) 10g of Betaquik with lunch, no breakfast (i.e BQ10 inverted) | Dietary Supplement: 10g of Betaquik<br>* BQ10 given with a regular standardize breakfast and BQ10 given at noon without lunch.<br>* Other names: BQ10;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Concentration of plasma ketones (acetoacetate and B-hydroxybutyrate) | To compare acute ketonemia following different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol. | 8 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Concentration of plasma glucose | To compare acute glucose following different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol. | 8 hours | 
| Concentration of plasma insulin | To compare acute insulin following different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol. | 8 hours | 
| Concentration of plasma free fatty acids | To compare acute free fatty acids following different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol. | 8 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Ketones, Medium Chain Triglycerides, Glucose, Insulin, Free fatty acids