Power Production in Older Adults With Knee Osteoarthritis

Study Overview
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Brief Summary
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Knee osteoarthritis is an important cause of functional disabilities at old age. Previous research has demonstrated that individuals with knee osteoarthritis have reduced knee-extensor strength in comparison to healthy individuals. However, rapid power production declines more than strength as a consequence of ageing and is more predictive of functional capacity. However, limited research has investigated whether individuals with knee osteoarthritis have reduced ability to develop strength and power rapidly on top of reduced maximal strength capacities, which is the primary aim of the current study.

Official Title
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Power Production in Older Adults With Knee Osteoarthritis Compared to Healthy Counterparts

Conditions
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Osteo Arthritis Knee

Intervention / Treatment
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* Diagnostic Test: Muscle function test


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Group with knee osteoarthritis: - Diagnosed with knee osteoarthritis based on RX. Exclusion Criteria: Healthy group: Systematic engagement in (resistance) exercise in the 12-months prior to participation Cardiovascular disease Neurological disorders Cognitive malfunctioning Severe knee or hip problems Group with knee osteoarthritis: Systematic engagement in (resistance) exercise in the 12-months prior to participation Cardiovascular disease Neurological disorders Cognitive malfunctioning Severe hip problems

Ages Eligible for Study
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Minimum Age: 50 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Older adults with knee osteoarthritis (>50 years)<br> | Diagnostic Test: Muscle function test<br>* Power and strength tests of the knee-extensor muscles, handgrip strength, functional capacity tests<br>|
| Healthy older adults (> 50 years)<br> | Diagnostic Test: Muscle function test<br>* Power and strength tests of the knee-extensor muscles, handgrip strength, functional capacity tests<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of power development | Subjects perform a test protocol on a Biodex dynamometer, consisting of isotonic contractions of the leg-extensor muscles. Subjects are instructed to kick as fast as possible against different (relative) loads. The rate of power development (watt/s) is defined as the linear slope of the power-time curve and is measured from the onset of movement till peak power. | up to 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Maximal isometric strength | Maximal strength (Nm) is measured by means of unilateral isometric knee-extensor tests on a Biodex dynamometer. | up to 3 months | 
| Maximal isokinetic strength | Maximal strength (Nm) is measured by means of unilateral isokinetic knee-extensor tests on a Biodex dynamometer. | up to 3 months | 
| Stair Climbing performance | Stair ascent duration (in s), the time needed to ascent a flight of stairs. | up to 3 months | 
| Gait speed | The average speed to walk 10m as fast as possible (in m/s). | up to 3 months | 
| 5 repetition sit-to-stand test | The time needed to perform 5 sit-to-stand transitions (in s). | up to 3 months | 
| Timed-up-and-go | The time needed to stand up from a chair, walk 3m, turn, walk back and sit down. | up to 3 months | 
| Handgrip strength | Handgrip strength (kg) evaluated with Jamar dynamometer. | up to 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Knee osteoarthritis, power production, functional capacity