Imaging of Cognition, Learning, and Memory in Aging

Study Overview
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Brief Summary
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This investigation is designed to study how the brain functions when it is performing explicit memory tasks, and furthermore how the brain systems supporting performance on these tests change as a function of aging. Implicit memory tasks may be distinguished from explicit memory tests in that explicit memory characterizes the directed or intentional recollection of previously learned information or events. In contrast, implicit (or nonconscious) memory is expressed in the facilitation of performance on some task or judgment on a stimulus owing to a prior presentation of that stimulus, without any necessary conscious awareness of the prior presentation. The investigators propose to use functional Magnetic resonance Imaging (fMRI) to measure brain activity during the performance of carefully designed explicit memory tasks. Comparison of brain activity during the different test conditions will provide information about the brain areas that are involved in mediating specific aspects of performance. Both older and younger individuals will be tested in order to understand age related changes in the brain activity. In order to examine the interactions between participants' differential levels of amyloid burden and their performance on cognitive tasks and fMRI neural activation, the investigators also propose PET imaging of older participants.

Detailed Description
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The basic approach to measuring the brain activity associated with a given cognitive process (or processes) is as follows: It is known that increases in brain neuronal activity are associated with local increases in energy metabolism. Under normal circumstances, increases in brain metabolism lead to local changes in blood oxygenation in venules and larger veins. This change in blood oxygenation can be detected imaging methods which are sensitive to the differences in magnetic state between oxygenated and deoxygenated hemoglobin. The ultimate benefit of this research is to better understand how changes in both performance and the brain organization underlying that performance are affected by aging.

Official Title
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Imaging of Cognition, Learning, and Memory in Aging

Conditions
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Alzheimer's Disease

Intervention / Treatment
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* Drug: Florbetaben


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Aged 20-30 or 60-70 Residing near Columbia University Medical Center Must be willing and able to participate Exclusion Criteria: Have a contraindication to PET (e.g, metallic implants, pacemaker, claustrophobia, or cannot lie flat for one hour) Pregnancy Lactating Women Current, past, or anticipated exposure to radiation Significant active physical illness

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Participants aged 60-70<br>Participants age 60-70 will receive Florbetaben PET tracer to identify presence of amyloid burden. | Drug: Florbetaben<br>* This is a purely observational study. Results of the Florbetaben PET scan will be correlated with other observations.<br>* Other names: F-18 BAY;|
| Participants aged 20-30<br>Younger participants will not undergo PET scanning that will be studied with other methods. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cognition as measured with cognitive evaluations | We will assess the relationship between the presence of amyloid and cognition as measured with standard cognitive and neuropsychological tests | cross sectional |