Proflaxis Using Hydroxychloroquine Plus Vitamins-Zinc During COVID-19 Pandemia

Study Overview
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Brief Summary
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Healthcare professionals mainly doctors, nurses and their first degree relatives (spouse, father, mother, sister, brother, child) who have been started hydroxychloroquine(plaquenil) 200mg single dose repeated every three weeks plus vitaminC including zinc once a day were included in the study. Study has conducted on 20th of march. Main purpose of the study was to cover participants those who are facing or treating COVID19 infected patients in Ankara.

Detailed Description
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Healthcare professionals mainly doctors, nurses and their first degree relatives (spouse, father, mother, sister, brother, child) who have been started hydroxychloroquine(plaquenil) 200mg single dose repeated every three weeks plus vitaminC including zinc once a day were included in the study. Study has conducted on 20th of march. Main purpose of the study was to cover participants those who are facing or treating COVID19 infected patients.PArticipants, age, sex, BMI, smoking history, comorbid disease were also registered.

Official Title
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Proflaxis for Healthcare Professionals Using Hydroxychloroquine Plus Vitamin Combining Vitamins C, D and Zinc During COVID-19 Pandemia: An Observational Study

Conditions
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Pneumonitis, Coronavirus Infection

Intervention / Treatment
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* Drug: Plaquenil 200Mg Tablet


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: person who are working as health professional with contact to known COVID positive case Their first degree relatives (child, spouse or parents) must be able to swallow tablets Exclusion Criteria: Already using plaquenil for other reasons (RA etc) person with the diagnosis of COVID infection Person with the condition may cause complications with this medication (severe CVD, av block, already has ophtalmological complications, organ failure of any degree etc). Documented allergic history to chloroquine; Documented history of hematological system diseases; Documented history of chronic liver and kidney diseases; Documented history of cardiac arrhythmia or chronic heart diseases; Documented history of retina or hearing dysfunction; Documented history of mental illnesses; 10. Use of digitalis due to the previous disease.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Hydroxychloroquine<br>Subjects with prophylaxis | Drug: Plaquenil 200Mg Tablet<br>* health workers under risk who took this medications<br>* Other names: Redoxan;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Protection against COVID-19 | persons who took this medication should not have an infection | 4 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Hydroxychloroquine, coronavirus, prophylaxis, healthcare professional, outbreak