The Influence of Type of Anesthesia on Postoperative Pain

Study Overview
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Brief Summary
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The investigators designed a multi-center prospective randomized controlled trial to study the influence of the type of anesthesia on postoperative pain after laparoscopic colorectal cancer surgery. Half of the participants will be anesthetized with propofol and remifentanil, while the other half will be anesthetized with sevoflurane and remifentanil during the surgery. The investigators will measure opioid consumption and pain score in the acute postoperative phase.

Detailed Description
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Previous studies showed that patients receiving total intravenous anesthesia (TIVA) with propofol are associated with less postoperative pain and less opioid consumption compared with inhalation anesthesia. However, some studies showed conflicting results. In colorectal surgery, there are only retrospective studies that showed the analgesic effect of TIVA and inhalation anesthesia. The investigators designed a multi-center prospective randomized controlled trial and hypothesized that TIVA with propofol would be associated with reduced postoperative opioid consumption and less postoperative pain compared with sevoflurane in laparoscopic colorectal cancer surgery.

Official Title
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The Influence of Type of Anesthesia on Postoperative Pain After Laparoscopic Colorectal Cancer Surgery: Multi-center Prospective Randomized Controlled Study

Conditions
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Colo-rectal Cancer, Anesthesia

Intervention / Treatment
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* Drug: Propofol
* Drug: Sevoflurane


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adult patient scheduled for elective laparoscopic colorectal cancer surgery Exclusion Criteria: Pregnant Conversion from laparoscopic to open surgery Allergy to anesthetics and analgesics Previous abdominal surgery Chronic pain Chronic analgesic usage

Ages Eligible for Study
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Minimum Age: 19 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Inhalation anesthesia<br>Patients are anesthetized with sevoflurane and remifentanil infusion for maintenance of anesthesia during the surgery | Drug: Sevoflurane<br>* General anesthesia during the laparoscopic colorectal surgery is achieved by using an inhalation agent (Sevoflurane).<br>* Other names: Sevoflurane inhalant product;|
| Experimental: Total intravenous anesthesia<br>Patients are anesthetized with target-controlled intravenous infusion of propofol and remifentanil infusion for maintenance of anesthesia during the surgery | Drug: Propofol<br>* General anesthesia during the laparoscopic colorectal surgery is achieved by using a target-controlled intravenous infusion of propofol.<br>* Other names: Propofol 2%;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative 24 h opioid consumption | Cumulative opioid consumption for pain control 24 hours after the surgery | 24 hours after the surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative 48 h opioid consumption | Cumulative opioid consumption for pain control 48 hours after the surgery | 48 hours after the surgery | 
| Numerical rating scale (NRS) | Numerical rating scale (NRS) pain score 24 and 48 hours after the surgery. NRS is an 11-point scale for patient self-reporting of pain; 0-10 where 0 is no pain and 10 is the worst pain imaginable. | 24 and 48 hours after the surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Postoperative pain, Opioid consumption, Intraoperative anesthesia