Establishment of a Tumor Bank for Blood Samples

Study Overview
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Brief Summary
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Establishment of a tumor bank, consisting of blood samples of tumor patients and healthy people as controls. The blood samples will be collected systematically together with the corresponding clinical data. The biological samples, the clinical date together with prospective experimental date constitute the entity of the tumor bank.

Detailed Description
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Recent progress in diagnosis and therapy of cancer diseases can be ascribed mainly to translational research. The relevance of translational oncology will only increase in the future -From bench to bedside - the swift implementation of new science research results in clinical studies in order to expedite progress in clinical cancer therapy for the benefit of the patient. Its almost a matter of course in the medical science today to collect biological samples together with clinical information thereby creating the foundation for future excellent fundamental research. The aim of this tumor bank is to consist of biological samples (together with a tissue bank - see EK 260/2003) and isolates of tumor patients and healthy people as controls. The biological samples, the clinical date together with prospective experimental date constitute the entity of the tumor bank. The content of the tumor bank can provide essential material for current and future research (e.g. analyses of prognostic or predictive tumor markers; genetically analysis (polymorphism, mutation, hypermethylation; verification and characterisation of disseminated tumor cells).

Official Title
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Establishment of a Blood Sample Bank in the Field of Gynaecological Oncology.

Conditions
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Ovarian Neoplasms, Breast Neoplasms, Colorectal Neoplasms, Neoplasms of the Female Genitalia, Lung Neoplasms, Endocrine Gland Neoplasms

Intervention / Treatment
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* Other: Blood collection


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Male/Female Age 18 to 90 years max. Just one current known malignant disease or Just one current inflammatory disease Exclusion Criteria: Inflammatory disease and malignant disease multiple malignancies multiple diseases underage

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Malignant tumors<br>Patients who have one of the Neoplasms stated above under conditions. Blood samples will be taken. | Other: Blood collection<br>* Blood sample is collected during routine blood collection by a medical doctor. No more than 60ml (max.) at one timepoint.<br>|
| Benign controls<br>Patients with a benign tumor or an inflammatory disease - to be matched by age and affected organ with a patient with a malignant disease. Blood samples will be taken. | Other: Blood collection<br>* Blood sample is collected during routine blood collection by a medical doctor. No more than 60ml (max.) at one timepoint.<br>|
| Healthy controls<br>People/patients who have no known disease at time of blood sampling or are admitted to the hospital for minor interventions and have no inflammatory disease. Blood samples will be taken. | Other: Blood collection<br>* Blood sample is collected during routine blood collection by a medical doctor. No more than 60ml (max.) at one timepoint.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Establishment of blood/tissue bank consisting of oncological samples from cancer patients and benign and healthy controls. |  | 14 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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circulating tumor cells, CTC, tumor marker