Maternal Serum Amyloid A Levels in Pregnancies Complicated With Preterm Labour.

Study Overview
=================
Brief Summary
-----------------
The aim of the current study is to assess the accuracy of maternal serum amyloid A for prediction of preterm labor in women with threatened preterm labor.

Official Title
-----------------
Maternal Serum Amyloid A Levels in Pregnancies Complicated With Preterm Labour.

Conditions
-----------------
Preterm Labor

Intervention / Treatment
-----------------
* Diagnostic Test: serum amyloid a test


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Pregnant women, age 18 - 35. Gestational age: 28 - 36+6 weeks. Singleton pregnancy. No past history of any medical disorder and with no other medical complications during pregnancy Nonsmoker. Diagnosis of preterm labor is based on the American College of Obstetricians and Gynecologists Guidelines Criteria of preterm delivery: Gestational age: 28 - 36+6 weeks Presence of uterine contractions (at least 4 in 20 minutes or 8 in 60 minutes) cervical dilation ≥ 4 cm Cervical effacement ≥ 80%. Exclusion Criteria: Of any patient with the following risk factors for preterm labor: Over distended uterus . hemorrhage Uterine anomalies

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| women with preterm labor<br> | Diagnostic Test: serum amyloid a test<br>* Women who are diagnosed with preterm labor (28-36 weeks) will be enrolled in this study. Serum samples will be collected from all women before any intervention. All women will be sampled once at the time of admission. Venous blood sample (5 c.c) will be taken from each participant for examination of serum amyloid A. The collected blood will be centrifuging and serum will be stored to measure the level of amyloid A by (ELISA) technique in clinical pathology department- Ain shams University<br>|
| women delivered at full term<br> | Diagnostic Test: serum amyloid a test<br>* Women who are diagnosed with preterm labor (28-36 weeks) will be enrolled in this study. Serum samples will be collected from all women before any intervention. All women will be sampled once at the time of admission. Venous blood sample (5 c.c) will be taken from each participant for examination of serum amyloid A. The collected blood will be centrifuging and serum will be stored to measure the level of amyloid A by (ELISA) technique in clinical pathology department- Ain shams University<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| prevalence of Amyloid A level in women with preterm labour | venous sample will be taken from each participant from onset of labour, Amyloid a level will be calculated | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| neonatal complications | preterm baby will be examined at neonatal intensive care unit by neonatologist. • Admission to Neonates intensive care unit. | 6 months |