Ablative Radiotherapy to Restrain Every Metastasis Safely Treatable (ARREST-2): A Randomized Phase II/III Trial

Study Overview
=================
Brief Summary
-----------------
This is a phase II/III international multicentre randomized trial. Patients will be randomized in a 1:2 ratio between the standard of care (Arm 1) and SABR (Arm 2) to all sites of disease. The study will start as a phase II trial with an opportunity to convert to a phase III trial. The objective of this trial is to determine the impact of SABR on overall survival, progression-free survival, quality of life, and toxicity in patients with polymetastatic disease.

Detailed Description
-----------------
A defining hallmark of cancer is its capability to metastasize. With few exceptions, patients with metastatic disease are considered incurable, and when offered treatment, the intent is to palliate symptoms and delay the inevitable morbidity and mortality that accompanies disease progression. Systemic therapy has been and remains the mainstay of treatment for metastatic disease, however the decision to initiate or continue systemic therapy is a balance of the anticipated benefits and the adverse effects of treatment. Virtually all patients eventually reach a point where systemic therapy will be ceased. Therapeutic radiotherapy in cancer care can be prescribed with curative or palliative intent. Palliative radiotherapy has long held a role in improving or stabilizing symptoms such as pain, bleeding, or neurologic dysfunction by delivering relatively low radiation doses to metastatic tumours. While palliating symptoms continues to be an important indication, the use of high dose, conformal radiotherapy, termed stereotactic ablative radiotherapy (SABR), has gained traction as an alternative treatment option for select metastatic patients, primarily those with oligometastatic disease. The objective of this trial is to determine the impact of SABR on overall survival, progression-free survival, quality of life, and toxicity in patients with polymetastatic disease.

Official Title
-----------------
Ablative Radiotherapy to Restrain Every Metastasis Safely Treatable (ARREST-2): A Randomized Phase II/III Trial

Conditions
-----------------
Metastatic Cancer

Intervention / Treatment
-----------------
* Radiation: Arm 2: SABR
* Radiation: Arm 1: Standard of Care


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age 18 or older willing and able to provide informed consent ECOG performance status 0-2 Life expectancy > or equal to 6 months Histologically confirmed malignancy with evidence of metastatic disease on imaging All sites of disease can be safely treated on a preliminary radiation plan > or equal to 11 metastases (the primary tumor does not have to be controlled and can be included as a target if it can feasibly and safely be treated with SABR. If the primary tumor is treated, a minimum of 12 targets are required0 at least 11 metastases are required in addition to the primary tumor.) Investigations required within 12 weeks of enrollment: Brain: MRI is required for all patients with known untreated or previously treated brain metastases. MRI is strongly recommended for all tumor sites with a propensity to develop brian metastases. Body: 18-FDG PET/CT imaging is recommended, except for tumors where FDG uptake is not expected (e.g. prostate, renal cell carcinoma). PSMA-PET or choline-PET is recommended for prostate cancer. In situations where a PET scan is unavailable, or for tumors that do not take up radiotracer, a CT neck/chest/abdomen/pelvis and bone scan are required. Liver: For patients with liver metastases, a diagnostic or simulation MRI is required to confirm the total number of metastases. No plans for systemic therapy (i.e. chemotherapy, targeted agent, immunotherapy) for 3 months from the time of enrolment. Reasons may include: a break from systemic therapy is desired by the patient and medical oncologist, the patient declines next line of systemic therapy, or no further systemic therapy options are available. Exceptions include hormone therapy for breast cancer or prostate cancer, which may be continued. SABR or palliative radiotherapy should commence no later than 2 weeks after randomization. For patients with brain metastases that are going to be treated regardless of the study arm, there must be additional extracranial disease present that will be treated with SABR on Arm 2 and not treated with SABR on Arm 1. Exclusion Criteria: Serious medical comorbidities precluding radiotherapy. These include interstitial lung disease in patients requiring thoracic radiation, Chrohn's disease in patients where the GI tract will receive radiotherapy, ulcerative colitis where the bowel will receive radiotherapy and connective tissue disorders such as lupus or scleroderma. For patients with liver metastases, moderate/severe liver dysfunction (Child-Pugh B or C) Substantial overlap with a previously treated radiation volume. Prior radiotherapy is allowed, as long as the composite plan meets dose constraints herein. For patients treated with radiation previously, biologically effective dose calculations should be used to equate previous doses to the tolerance doses listed in Appendix 1. All such cases must be discussed with the study PI. Inability to treat all sites of disease. Any brain metastasis >3 cm in size or a total volume of brain metastases greater than 30 cc. Solitary or dominant brian metastasis requiring surgical decompression. Radiologic evidence of spinal cord compression. Disseminated disease, including leptomeningeal metastases, peritoneal metastases/carcinomatosis, malignant pleural effusion, and lymphangitis carcinomatosis. Pregnant or lactating women.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Standard of Care<br>Standard or care palliative radiotherapy (includes the option for no treatment) | Radiation: Arm 1: Standard of Care<br>* Standard of care palliative radiotherapy<br>|
| Active Comparator: SABR<br>SABR to all tumors 6Gy x 5 over 3 weeks | Radiation: Arm 2: SABR<br>* SABR to all tumors 6 Gy x 5 over three weeks<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overall Survival | Defined as the time form randomization to death from any cause. | Time from randomization to death from any cause, patients followed for 5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Progression-free survival | Defined as the time from randomization to disease progression at any site or death. | Time from randomization to disease progression at any disease site, or death. Up to 5 years | 
| Quality of life- An individuals perception of their position in life in the context of the culture and value systems in which they live and in relation to their goals, expectations, standards and concerns. | Measured using the Functional Assessment of Cancer Therapy: General (FACT-G) | Measured at baseline, then every 3 months from randomization until 2 years, then every 6 months until 5 years. | 
| Quality of life- An individuals perception of their position in life in the context of the culture and value systems in which they live and in relation to their goals, expectations, standards and concerns. | Measured using the Functional Assessment of Cancer Therapy: EQ-5D-5L | Measured at baseline, then every 3 months from randomization until 2 years, then every 6 months until 5 years. | 
| Toxicity of Ablative Radiotherapy | Will be assessed using the National Cancer Institute Common Toxicity Criteria (NCI-CTC) version 5 for each relevant organ site treated. | Measured at baseline, on treatment, 6 weeks post treatment, every 3 months from randomization until 2 years, then every 6 months until 5 years. |