Study of Psychosexual Impact of Cancer-Related Infertility in Women: Third Party Reproductive Assistance

Study Overview
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Brief Summary
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This study aims to learn about the needs and feelings of women who are infertile. Being infertile means not being able to have a child without the help of a third party. There are other options for building a family. The researchers are interested in the participants' thoughts about these options and want to learn about the experiences of infertile women due to cancer treatment as well as women who are infertile due to other causes. The researchers hope that what they learn will allow them to better care for infertile women in the future.

Detailed Description
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As part of this study, you will be asked to fill out a series of questionnaires. These questions will ask about your feelings, sexual function, quality of life, and ideas about reproductive options. We will also ask some questions about you, your health, and your medical history. You can choose to answer these questions either at one of your doctor visits or over the telephone. You can decide the best way to complete this assessment.

Official Title
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Cross-Sectional Study of Psychosexual Impact of Cancer-Related Infertility in Women: Third Party Reproductive Assistance

Conditions
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Leukemia, Non-Hodgkin's Lymphoma, Uterine Cancer, Vaginal Cancer, Infertility, Cervical Cancer, Endometrial Cancer

Intervention / Treatment
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* Behavioral: survey instrument


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Study group of gynecologic cancer survivors and BMT/SMT cancer survivors: History of a primary diagnosis of gynecologic cancer or history of any primary malignancy treated with BMT/SCT No evidence of disease for at least one year At least 18 years of age not greater than 49 years of age at time of study recruitment No other cancer history Have impaired fertility: lack of uterus but intact ovaries or lack of ovaries or lack of ovarian function based on the FSH determination but intact uterus Have not started or have not completed childbearing Able and willing to provide informed consent Ability to comprehend and complete questionnaire in English Comparison Group of non-cancer infertile women awaiting egg (oocyte) donation: No cancer history At least 18 years of age not greater than 49 years of age at time of study recruitment In ovarian failure and on a waiting list for egg (oocyte) donation Have not started or have not completed childbearing Able and willing to provide informed consent Ability to comprehend and complete questionnaire in English Exclusion Criteria: Inability to participate in an informed consent process Patients with a psychiatric disorder precluding response to the survey

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 49 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>gynecologic cancer survivors | Behavioral: survey instrument<br>* Participants will be mailed or given a one time survey instrument and data will be collected either in person or by telephone. We expect the study survey to take approximately 35-45 minutes to complete. The domains assessed will include psychological functioning, reproductive knowledge, perception of third party reproduction and concerns, sexual functioning, and quality of life.<br>|
| 2<br>survivors of any type of malignancy with history of BMT/SCT | Behavioral: survey instrument<br>* Participants will be mailed or given a one time survey instrument and data will be collected either in person or by telephone. We expect the study survey to take approximately 35-45 minutes to complete. The domains assessed will include psychological functioning, reproductive knowledge, perception of third party reproduction and concerns, sexual functioning, and quality of life.<br>|
| 3<br>non-cancer infertile women awaiting third party reproduction | Behavioral: survey instrument<br>* Participants will be mailed or given a one time survey instrument and data will be collected either in person or by telephone. We expect the study survey to take approximately 35-45 minutes to complete. The domains assessed will include psychological functioning, reproductive knowledge, perception of third party reproduction and concerns, sexual functioning, and quality of life.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Investigate emotional, sexual functioning, reproductive concerns and QOL experience of 3 groups of infertile women: gynecologic cancer survivors, survivors of hematological malignancies, & the non-cancer infertile women awaiting 3rd party reproduction |  | 2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Assess and describe the attitudes towards, knowledge of, and utilization of third party reproduction of the study participants (cancer and non-cancer infertile groups) |  | 2 years | 
| Compare the main domains of depression, distress, sexual functioning and overall QOL of the gynecologic cancer survivors and survivors of a hematological malignancy with history of BMT/SCT to non-cancer infertile women awaiting third party reproduction |  | 2 years |