Study of Genetic and Cellular Immunological Parameters Predictive of Disease-free Survival in Patients With Metastatic Cancer

Study Overview
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Brief Summary
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The aim of this study is to characterize the genetic and cellular immunological parameters of metastatic digestive cancer patients having short and long responses to chemotherapy.

Official Title
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Study of Genetic and Cellular Immunological Parameters Predictive of Disease-free Survival in Patients With Metastatic Cancer

Conditions
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Metastatic Cancer

Intervention / Treatment
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* Other: Additional biological samples


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: For all patients: signed written informed consent For cohort A: patient with metastatic colorectal cancer with first-line therapy by chemotherapy +/- surgery and with a disease-free survival > or = at 20 months Ct-scan realized in the previous 4 weeks and showing no progression according to the Recist criteria v1.1 For cohort B: patient treated for metastatic colorectal cancer and chemotherapy responder (obtention of an objective response according to the Recist criteria V1.1 in first-line therapy), with a disease-free survival < 10 months (disease progression must be confirmed by CT scan evaluation according to Recist v1.1 criteria) For cohort C: patients with no metastatic rectum cancer in complete remission after chemotherapy and/or radiotherapy For cohort D: patients with metastatic or locally advanced cancer in complete remission after treatment, non eligible in the other cohorts Exclusion Criteria: For all patients: patient with any medical or psychiatric condition or disease which would make the patient inappropriate for entry into this study patient with a neurodegenerative disease patient under guardianship, curator or under the protection of justice

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Additional biological samples<br>Additional blood samples will be realized at the inclusion of patients. Two optional blood samples could be realized if necessary with at least 3 months apart. Peripheral Blood Mononuclear Cells (PBMC) will be collected. Tissue tumor will be collected if available. | Other: Additional biological samples<br>* blood and tissue samples<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| frequency of peripheral T cell immune responses in the presence of antigenic peptides associated with digestive cancer |  | at inclusion | 
| progression-free survival | time interval between the date of inclusion and the date of first progression or death from any cause. | within 5 years after the inclusion |