Clinical Evaluation of Different Universal Adhesive Systems in Non-carious Cervical Lesions.

Study Overview
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Brief Summary
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The aim of the study is to compare the performance of universal adhesives containing different-solvent-based in the restoration of non-carious cervical lesions (NCCLs).

Detailed Description
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The study was approved by the Ethics Committee of the Istanbul University Faculty of Dentistry in accordance with protocol no. 2019/37-Rev/2. All participants will be informed about the study and will sign the written informed consent prior to the first treatment. The tested materials are the universal adhesive systems: Single Bond Universal (3M ESPE, St. Paul, MN, USA) and G-Premio Bond (GC Corporation, Tokyo, Japan). Both adhesive systems will be used in selective-etch approach. All restorations will replaced by a single experienced dentist. In this study PASS 11 Software was used to calculate the sample size. At least 230 restorations (n=115) will be included for this study. The patients will be given local anesthesia if required to prevent discomfort during the intervention. Prior to the restorative procedure the teeth will be cleaned with a pumice water slurry, using a rubber cup. The walls of the lesions are gently and superficially roughened using a round coarse diamond bur before adhesive procedures. Isolation of the tooth will be achieved by the use of cotton rolls and a saliva aspirator, a retraction cord (Ultrapak, Ultradent Products, Inc., South Jordan, USA). Both adhesives will be applied in manufacturer' s instructions with random order, by which the first randomly selected adhesive will be used to restore the tooth with the lowest tooth number (according to the FDI system), and the alternative adhesive will be used for the tooth with the second lowest tooth number. This method will be used for every other tooth requiring a cervical restoration. After adhesive procedures, resin composite will be placed and each increment light cured for 20 seconds (Elipar S10, 3M ESPE, St.Paul, MN, USA). The restorations are then finished and polished. Restorations will be assessed 7 days after placement (baseline) and after 6, 12, 18, and 24months. Clinical examination will be performed by two blinded examiners, who were not involved in the treatments. Each restoration will be evaluated clinically using a dental loupe according to FDI World Dental Federation criteria. Three main groups- esthetic, functional, biological properties- and their sub-categorizes of FDI World Dental Federation criteria will be scored on a scale of 1 to 5. Esthetic properties: Surface lustre, surface staining, marginal staining, color match and translucency, esthetical anatomical form Functional properties: Fracture of material and retention, marginal adaptation, wear, approximal anatomical form, patient's view. Biological properties: Post-operative sensitivity, recurrence of caries, erosion, abfraction, tooth integrity, periodontal response, adjacent mucosa, oral and general health. Statistical analysis will be performed using IBM SPSS V23 Software. The data is analyzed with Chi- Square, Friedman Test, Bonferroni Test adjustment, Wilcoxon Tests (p < 0.05).

Official Title
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Clinical Evaluation of Different Solvent-based Universal Adhesive Systems in Non-carious Cervical Lesions.

Conditions
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Non-carious Cervical Lesions

Intervention / Treatment
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* Device: Single Bond Universal
* Device: G-Premio Bond


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Participant age should be 18-65 years. Good general health condition Good oral hygiene Should have at least 4 noncarious cervical lesion Must not have rampant caries At least 20 teeth in occlusion Exclusion Criteria: Serious medical problems, allergies to product ingredients Poor oral hygiene Severe periodontal problems Caries or restorative treatment on teeth included in the study Parafunctional behavior Abutment of tested teeth to a removable prosthesis.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: A randomized controlled clinical trial
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Group Single Bond Universal<br>Single Bond Universal adhesive system with selective-etch approach following the manufacturer's instruction | Device: Single Bond Universal<br>* Adhesive system<br>|
| Experimental: Group G-Premio Bond<br>G-Premio Bond Adhesive System with selective-etch approach following the manufacturer's instruction | Device: G-Premio Bond<br>* Adhesive system<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| FDI World Dental Federation criteria | Retention and marginal adaptation | 24-months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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universal adhesive, non-carious lesions, randomized clinical trial