Transcranial Magnetic Stimulation and Bulimic Craving

Study Overview
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Brief Summary
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Bulimic patients suffering from binge eating or craving a pressing need to eat, with a sense of unease and anxiety, relieved by food intake. The phenomenon of craving bulimia may be considered appropriately by using paradigms developed in the framework of embodied cognition theories. In bulimic, a study with 20 bulimic patients proved an automatic attraction (unconscious) for food in these patients, as measured by reaction time. Moreover, a therapeutic explored in bulimia (particularly on reducing craving), is repeated transcranial magnetic stimulation (rTMS). Studies have shown that a single session of rTMS to the dorsolateral prefrontal cortex left (DLPFC) reduces significantly the food craving among bulimics, 24 hours after stimulation. But the therapeutic efficacy of TMS on bulimia to more than 24 hours has not yet been demonstrated, and the psycho-cognitive underlying mechanisms have not yet been explored.

Detailed Description
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The exams / treatments of the study include: a 20 minute session of rTMS at a frequency of 10 Hz. cognitive testing and attention, which will be made on the computer before and 24 hours after the session of rTMS. Cognitive test consist in , on a computer screen: Is first displayed, food and non-food words. The patient must pull a lever to it if the letter A is present in the word and push the lever if the letter A is missing the word. Then presents a series of food and non-food words. The patient must pull a lever to it if it deems that the word has a positive meaning and push the lever if it determines that the word has a negative meaning

Official Title
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Transcranial Magnetic Stimulation, Embodied Cognition and Bulimic Craving

Conditions
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Bulimia

Intervention / Treatment
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* Device: rTMS session
* Device: rTMS Placebo (SHAM)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: right-handed patient Patients without psychotropic treatment or treatment with a stable and unchanged for over a month. Normal BMI Exclusion Criteria: Previous history of seizures or epilepsy. Participants with a somatic problem restricted movement or an uncorrected visual acuity problem. History of head trauma, neurological disease or unstabilized serious physical illness. Major Depressive Episode at the time of the study

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: rTMS session<br>Patients will have a 20 minute session of rTMS at a frequency of 10 Hz. | Device: rTMS session<br>* One session of rTMS at a frequency of 10 Hz during 20 minutes<br>|
| Placebo Comparator: rTMS placebo (SHAM) session<br>Patients will have a 20 minute session of placebo rTMS | Device: rTMS Placebo (SHAM)<br>* One session of placebo (SHAM) rTMS during 20 minutes<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Motor response time | time taken to pull or push the lever in cognitive tests (composite measure) | 24h after rTMS session | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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bulimia, repetitive transcranial magnetic stimulation (rTMS)