Avenanthramides and Exercise

Study Overview
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Brief Summary
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The aim of the proposed study is to examine whether long-term dietary supplementation (8 weeks) of an oat flour cookie rich in avenanthramides (AVA) could enhance blood antioxidant capacity and reduce blood inflammatory markers after a downhill running (DR) protocol among human subjects.

Official Title
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Effect of Avenanthramides Supplement on Exercise-induced Physiological and Psychological Changes

Conditions
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Avenanthramides

Intervention / Treatment
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* Other: Avenanthramides


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 1. Male and female non-obese subjects (18kg/M2<BMI<28kg/M2) (age 20-45 years) will be recruited from the Twin Cities community. All participants will sign informed consent approved by UMN-IRB and are willing to avoid oat consumption and rigorous physical activity the day prior to and through test and to consume a low-polyphenol diet for 1 week prior to the study. The foods rich in polyphenols include all berries, apples, pears, citrus fruits, fruit juices, onions, chocolate, wine, coffee, tea, beans, nuts, soy products and most spices Exclusion Criteria: Presence of GI conditions that interfere with absorption; Clinically significant endocrine, cardiovascular, pulmonary, renal, hepatic, pancreatic, biliary or neurologic disorders; Major trauma or surgery within 3 months of visit; Cancer in the prior 2 years; Allergic to oat products; Women who are pregnant or lactating; Smoking; Drinking alcohol >5 drinks/week; Using nutraceuticals; Blood pressure medication; NSAID (>800 mg ibuprofen/week) Vitamin supplementation Anticoagulants or hypoglycemic drugs Oat products consumption and rigorous physical activity the day before the test and consumption of a high-polyphenol diet in week prior to the test. Moderate-intensity cardiorespiratory exercise training for ≥30 min•d-1 on ≥5 d•wk-1 for a total of ≥150 min•wk-1, vigorous-intensity cardiorespiratory exercise training for ≥20 min•d-1 on ≥3 d•wk-1 (≥75 min•wk-1), or a combination of moderate- and vigorous-intensity exercise to achieve a total energy expenditure of ≥500-1000 MET•min•wk-1

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Low-AVA oat flour cookies<br> | Other: Avenanthramides<br>* AVAs are a group of diphenolic acids that are found only in oats (Avena sativa).<br>|
| Experimental: High-AVA oat flour cookies<br> | Other: Avenanthramides<br>* AVAs are a group of diphenolic acids that are found only in oats (Avena sativa).<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mean and SD of plasma concentrations of Creatine Kinase |  | 0-72 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mean and SD of plasma concentrations of TNF-α |  | 0-72 hours | 
| Mean and SD of plasma concentrations of IL-6 |  | 0-72 hours | 
| Mean and SD of plasma concentrations of ICAM-1, VCAM-1, NF-κB (P65), NRB, NF-κB binding to DNA, 4-Hydroxynenenol, F2-isoprostane |  | 0-72 hours |