Transversus Abdominis Plane(TAP) Block, Local Infiltration and Intravenous Dexketoprofen in Inguinal Hernia Repair

Study Overview
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Brief Summary
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This study evaluates the compare the effects of ultrasound guided TAP block, local anesthetic infiltration to the incision line and intravenous dexketoprofen on postoperative analgesic efficacy and rescue tramadol consumption in inguinal hernia repairs.

Detailed Description
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Currently, multimodal techniques are used in inguinal hernia repairs in addition to pharmacological and regional techniques for postoperative analgesia.TAP block is performed on the principle of hydrodissection of the fascia between the internal oblique and transversus abdominis muscles of the abdominal wall muscles with local anesthetic drugs. Local anesthetic drugs provide analgesic effect up to 24 hours in the postoperative period by blocking the T6-L1 nerves in the facial plane. Local anesthetic infiltration which is one of the regional anesthetic techniques, is another method of postoperative analgesia. intravenous analgesic drug is also used as pharmacological postoperative analgesia method in most clinics.

Official Title
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Comparison of Postoperative Analgesic Efficacy of Preemptive Ultrasound-guided Transversus Abdominis Plane Block, Ultrasound-guided Local Infiltration and Intravenous Dexketoprofen in Inguinal Hernia Repair

Conditions
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Inguinal Hernia

Intervention / Treatment
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* Other: Transversus abdominis plane block
* Other: Local anesthetic infiltration
* Other: Intravenous dexketoprofen


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Subject who aged 18-75 years American Society of Anesthesiologist (ASA) I-III Subject undergoing unilateral or bilateral inguinal hernia repair Exclusion Criteria: Subject under 18 and over 75 years of age ASA IV History of allergy to agents Analgesic drug use in the last 48 hours Morbid obese (BMI> 35) Confusion Coagulopathy Local infection at the injection site Subject with heart, lung, hematologic, metabolic and endocrine disease Subject who did not want to be included in the study Subject who refused the spinal anesthesia Subject who failed the spinal anesthesia

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Group TAP<br>Ultrasound-guided TAP Block | Other: Transversus abdominis plane block<br>* Before surgery, Ultrasound-guided TAP block was performed preemptively to Group TAP patients.<br>|
| Active Comparator: Group Local<br>Ultrasound-guided Local Infiltration | Other: Local anesthetic infiltration<br>* Before surgery, Ultrasound-guided Local anesthetic infiltration to the surgical incision line was performed preemptively to Group Local patients.<br>|
| Active Comparator: Group Dexketoprofen<br>Intravenous Dexketoprofen | Other: Intravenous dexketoprofen<br>* Before surgery, 50 mg intravenous dexketoprofen was performed preemptively to Group dexketoprofen patients.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative rescue tramadol consumption | The mean tramadol consumption in the first 24 post-operative hours | 24 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Analgesic efficacy | Postoperative visual analog scale score recorded 0-10 (0 = no pain, 10 = severe pain) at 30. min, 1, 2, 4, 8, 12, 16 and 24 hours postoperatively | 24 hours | 
| Postoperative nausea-vomiting | Postoperative nausea-vomiting was evaluated with a 3-point system (0: no nausea and vomiting, 1: nausea, but no vomiting, 2: nausea with or without nausea) 24 hours postoperatively. | 24 hours |