Study of Motor Slowing in Parkinson's Disease by a Computerized Mental Chronometry Paradigm

Study Overview
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Brief Summary
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Action slowing has been demonstrated in many diseases. Parkinson's disease (PD) and Huntington's disease (HD) are two neurodegenerative diseases affecting the basal ganglia, particularly the medial globus pallidus, and the clinical expression of these two diseases is characterized by a combination of motor and cognitive disorders, but with two opposing patterns of dysfunction. Action slowing has been demonstrated in both of these diseases and has been extensively studied in Parkinson's disease, suggesting a perceptive-cognitive origin. Far fewer studies have been conducted in Huntington's disease. However, all of these studies were performed with different methodologies in small cohorts and the value of the proposed study is to use a validated and standardized computerized mental chronometry paradigm, providing a better understanding of the mechanisms of action slowing in these two diseases and to more clearly define a disease-specific profile.

Official Title
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Study of Motor Slowing in Parkinson's Disease by a Computerized Mental Chronometry Paradigm

Conditions
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Parkinson Disease, Huntington Disease

Intervention / Treatment
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* Behavioral: SRT


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Agreeing to participate in the study French mother tongue MMSE > 20/30 Specific to the MP and MH: Parkinson's disease: defined by the criteria of the UKPDSBB stage 1 , 2 or 3 Hoehn and Yahr (ON) age of onset of the disease known brain MRI performed during follow-up Huntington disease : genetically defined (CAG > 35) weaning neuroleptic ( Tercian® and Solian® : 2 days; Haldol® : 5 days ; Tiapridal® and Xenazine : 1 day ; Zyprexa® : 4 days) Early stage : Fahn and Shoulson I and II is a CFT score between 7 and 13 Exclusion Criteria: Illiteracy, writing or reading difficulties Visual perceptual auditory deficit or preventing reading, drawing, writing or understanding instructions Visual hallucinations Significant history may sound on cognition (unbalanced thyroid dysfunction, ischemic heart disease or embolic unstabilized or symptomatic, progressive neoplasia, chronic alcoholism weaned or not) Current or previous neurological diseases other than MH or MP: ischemic cerebral vascular accident or bleeding, head injuries (loss of higher knowledge in 15 minutes), epilepsy requiring treatment. Psychiatric disorders depression unless treated (stable treatment for 1 month) Psychotropic treatment (except anxiolytic, antidepressant steady since 1 month) Inability to achieve an autonomous operation without technical assistance over a distance of 20 meters. Inability to stand without technical assistance for 30 seconds.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Parkinson best-On<br>two hours after taking two tablets of 125 mg dispersible Modopar® | Behavioral: SRT<br>* simple reaction time ( SRT) defined as the fastest response time to a target stimulus ( phase worst -off at the Parkinson's patient )<br>|
| Parkinson worst-off<br>after a drug withdrawal period ( morning fasting all dopaminergic treatment since the day before midnight) | Behavioral: SRT<br>* simple reaction time ( SRT) defined as the fastest response time to a target stimulus ( phase worst -off at the Parkinson's patient )<br>|
| Huntington<br> | Behavioral: SRT<br>* simple reaction time ( SRT) defined as the fastest response time to a target stimulus ( phase worst -off at the Parkinson's patient )<br>|
| Control<br>Data collected from the existing database | Behavioral: SRT<br>* simple reaction time ( SRT) defined as the fastest response time to a target stimulus ( phase worst -off at the Parkinson's patient )<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| SRT | simple reaction time ( SRT) defined as the fastest response time to a target stimulus ( phase worst -off at the Parkinson's patient ) | Day 0 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Motor slowing, Computerized mental chronometry paradigm