Diagnostic Study of Transthoracic Echocardiography for Coronary Heart Disease

Study Overview
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Brief Summary
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This study is a prospective, single-center clinical trial，Comparison of transthoracic echocardiography and coronary angiography in coronary heart disease using a paired-analysis clinical trial.This study is based on the basis of clinical screening for coronary heart disease.

Detailed Description
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Patients who were hospitalized in our department of cardiology during the period of 2011.08-2019.01 will be consecutively enrolled.Thorough cardiac ultrasound and coronary angiography were performed to assess coronary stenosis after admission.To evaluate the sensitivity, specificity, misdiagnosis rate, and missed diagnosis rate of coronary heart disease by echocardiography as the gold standard for diagnosis of coronary angiography.

Official Title
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Diagnostic Study of Transthoracic Echocardiography for Coronary Heart Disease

Conditions
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Coronary Heart Disease

Intervention / Treatment
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* Diagnostic Test: Echocardiography test


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: First admitted to hospital for chest pain and considered for diagnosis of coronary heart disease. Patients with relatively stable disease who can withstand elective coronary angiography. Cardiac ultrasound assessment before coronary angiography during hospitalization. Exclusion Criteria: No coronary angiography record. No cardiac ultrasound record. Cardiac ultrasonography is completed after coronary angiography. Severe heart valve disease. Severe congenital heart disease. Hyperdynamic heart disease such as hyperthyroidism and anemia. Pulmonary heart disease. Hypertrophic obstructive cardiomyopathy. According to the guidelines for coronary heart disease diagnosis, patients do not need coronary angiography. Malignant tumor. Acute coronary syndrome. Pericardial disease. Previously diagnosed as coronary heart disease or PCI. Mental or legal incapacity.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Observation group<br> | Diagnostic Test: Echocardiography test<br>* Contrast echocardiography and coronary angiography<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| sensitivity, specificity, misdiagnosis rate and missed diagnosis | The sensitivity, specificity, misdiagnosis rate and missed diagnosis rate of echocardiography in diagnosis of coronary heart disease | 10 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Factors related to missed diagnosis and misdiagnosis in the diagnosis | Factors related to missed diagnosis and misdiagnosis in the diagnosis of CAD | 10 days | 
| Characteristics of coronary blood flow | Characteristics of coronary blood flow under echocardiography in patients with coronary heart disease | 10days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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coronary heart disease, echocardiography, coronary angiography