Cerebral Hemodynamics in Sleep Disorders

Study Overview
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Brief Summary
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The purpose of this study is to determine the relationship between sleep disorders and cerebral hemodynamics.

Detailed Description
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Sleep disorders continue to be the most unrecognized modifiable risk factor for stroke. The relationship between sleep disorders and vascular risk factors and stroke has been well-documented but not fully understood. The investigators hypothesize hemodynamics impairment to be its potential mechanism. It has been reported that sleep-related breathing disorder, a type of sleep disorders, contributed as a risk factor for stroke through hemodynamic and hematologic changes. The purpose of this study is to determine the relationship between different kind of sleep disorders and cerebral hemodynamics, including OSHAS, RLS, RBD, narcolepsy, etc. The dynamic cerebral auto-regulation (dCA) and Transcranial Doppler (TCD) will be used to evaluate cerebral hemodynamics.

Official Title
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Cerebral Hemodynamics in Sleep Disorders

Conditions
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Sleep Disorders, Intrinsic

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients with sleep disorders meet the Diagnostic Criteria for Sleep Dyssomnias sufficient bilateral temporal bone windows for insonation of the MCA Exclusion Criteria: middle cerebral artery (MCA) and/or other intracranial and/or extracranial major vascular 4 stenosis/occlusion, as diagnosed by a transcranial Doppler having a prior symptomatic cerebral vascular disease current arrhythmia, hyperthyroidism, anemia and unstable blood pressure, which may undermine hemodynamic stability inability to cooperate sufficiently to complete the dCA examination

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| patients with sleep disorders<br> | |
| normal individuals without sleep disorders<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| phase difference(PD) in degree | A dynamic cerebral auto-regulation parameter derived from transfer function analysis.Continuous cerebral blood flow velocities of bilateral middle cerebral artery will be assessed noninvasively using transcranial Doppler. Spontaneous arterial blood pressure will be simultaneously recorded using a servo-controlled plethysmograph on the left or right middle finger with an appropriate finger cuff size. Transfer function analysis will be used to derive the autoregulatory parameters. | 6 months | 
| the rate of recovery of cerebral blood flow velocity | A dynamic cerebral auto-regulation parameter derived from transfer function analysis.The details are same as outcome 1 | 6 months | 
| gain in cm/s/mmHg | A dynamic cerebral auto-regulation parameter derived from transfer function analysis.The details are same as outcome 1 | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| mean MCA blood flow velocity (mCBFV) changes from supine to upright position |  | 6 months | 
| pulsatility index (PI) changes from supine to upright position |  | 6 months | 
| resistance index (RI) changes from supine to upright position |  | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Sleep Disorders, Cerebral Hemodynamics, Dynamic Cerebral Auto-Regulation, Stroke