The Effect of Periodontal Treatment on Stress and Pregnancy Relationship

Study Overview
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Brief Summary
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There is a relationship between stress and pregnancy gingivitis. This relationship may be double-sided.

Detailed Description
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The aim of this clinical study was to determine the effect of non-surgical mechanical periodontal treatment on sex steroid and stress markers at pregnancy gingivitis. A total of 84 subjects; 22 pregnant women with gingivitis (group 1) and 25 pregnant women with periodontal healthy (pregnant group), group 2), 22 non-pregnant women with gingivitis (group 3) and 15 non-pregnant women with periodontal healthy (non-pregnant group), group 4) participated in this study. Clinically, plaque index, gingival index, and probing pocket depth were measured at baseline and after therapy.

Official Title
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Relationship of Sex Steroid and Stress Markers in Saliva and Gingival Crevicular Fluid With Pregnancy

Conditions
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Pregnancy Gingivitis

Intervention / Treatment
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* Other: Non-surgical periodontal treatment
* Other: Saliva samples
* Other: GCF samples


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: being between the ages of 24-50 being pregnant for 23-30 weeks (for pregnant individuals) not smoking. Exclusion Criteria: using antimicrobial or anti-inflammatory therapy within the previous 3 months, having systemic disease, having periodontitis, having deep caries lesions, and remnant roots and having lactation

Ages Eligible for Study
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Minimum Age: 24 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Pregnancy Group<br>GCF and saliva samples were taken from pregnant gingivitis patients before treatment and after 8 weeks. GCF and saliva samples were taken from pregnant periodontal healty individuals baseline and after 8 weeks. Intervention: Non-surgical periodontal treatment was performed for pregnant gingivitis patients. Gingival crevicular fluid (GCF) and saliva samples were taken. | Other: Non-surgical periodontal treatment<br>* Non-surgical periodontal treatment was performed for pregnant and non-pregnant gingivitis patients. Gingival crevicular fluid (GCF) and saliva samples were taken from all patients baseline and after 8 weeks.<br>Other: Saliva samples<br>* Saliva samples were taken from patients for the evaluation of sex steroid and stress markers baseline and after 8 weeks.<br>Other: GCF samples<br>* GCF samples were taken from patients for the evaluation of stress markers baseline and after 8 weeks.<br>|
| Active Comparator: Non-Pregnancy Group<br>GCF and saliva samples were taken from non-pregnant gingivitis patients before treatment and after 8 weeks. GCF and saliva samples were taken from periodontal healty individuals baseline and after 8 weeks. Intervention: Non-surgical periodontal treatment was performed for non-pregnant gingivitis patients. Gingival crevicular fluid (GCF) and saliva samples were taken. | Other: Non-surgical periodontal treatment<br>* Non-surgical periodontal treatment was performed for pregnant and non-pregnant gingivitis patients. Gingival crevicular fluid (GCF) and saliva samples were taken from all patients baseline and after 8 weeks.<br>Other: Saliva samples<br>* Saliva samples were taken from patients for the evaluation of sex steroid and stress markers baseline and after 8 weeks.<br>Other: GCF samples<br>* GCF samples were taken from patients for the evaluation of stress markers baseline and after 8 weeks.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Dehydroepiandrosterone (DHEA) | The changes in DHEA levels within 8 weeks. Higher values represent a worse outcome. The decrease in DHEA levels is expected after periodontal treatment. | Baseline and after 8 weeks | 
| estrogen | The changes in estrogen levels within 8 weeks. Higher values represent a worse outcome. The decrease in estrogen levels is expected after periodontal treatment. | Baseline and after 8 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Gingival index | The changes in gingival index level after periodontal treatment. Gingival index was measured for determining the severity of disease and clinical outcome. Higher values represent a worse outcome. After periodontal treatment, a reduction in gingival index value is expected. | Baseline and after 8 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Stress