The Impact of E-liquid Nicotine Content on Reinforcement in Current Smokers

Study Overview
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Brief Summary
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Participants will complete a phone screen and then one laboratory session. After completing in-person screening assessments, eligible participants will complete additional questionnaires. Participants will then choose an e-liquid flavor to use for the rest of the session. Participants will then sample two e-liquids that vary in nicotine content from little or no nicotine to a moderate level of nicotine, and questionnaires evaluating the subjective effects of each one. Participants will then complete a preference assessment where they choose between the two e-liquids. Participants will be blind to the nicotine contents.

Official Title
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The Impact of E-liquid Nicotine Content on Reinforcement in Current Smokers

Conditions
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Tobacco Use

Intervention / Treatment
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* Behavioral: E-liquid sampling and preference assessment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: At least 18 years old Daily cigarette smoking Have tried vaping devices on a minimum of one lifetime occasion Exclusion Criteria: Unwilling to use a vaping device during the session Break alcohol level > 0.01 (g/dL) Pregnant, trying to become pregnant, or breastfeeding Systolic BP greater than or equal to 160 mm/Hg or below 90 mm/Hg Diastolic BP greater than or equal to 100 mm/Hg or below 50 mm/Hg Heart rate greater than or equal to 105 bpm or lower than 45 bpm A current upper respiratory infection, recent cardiac event (in the last year), Buerger disease, irregular heartbeat or arrhythmia within the last year, previous allergic or adverse reaction to nicotine

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: E-liquid Group<br>Participants will sample two different e-liquids. | Behavioral: E-liquid sampling and preference assessment<br>* Participants will sample two different e-liquids that vary in nicotine content, complete questionnaires about each one, and then choose between the two e-liquids in a preference assessment task.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Product Evaluation Questionnaire | Ratings of the two e-liquids on a self-report questionnaire | One Day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Preference Assessment | Choices of each of the two e-liquids on a preference assessment | One Day | 
| Perceived Health Risk Questionnaire | Personal Health Risk Ratings about each of the two e-liquids | One Day | 
| Vaping Purchase Task | Hypothetical estimates of consumption of each of the e-liquids across a variety of prices | One Day |