Non-invasive Assessment of Pulmonary Vascular Resistance in Elderly Patients With Chronic Obstructive Pulmonary Disease

Study Overview
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Brief Summary
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Many studies have evaluated the viability of measuring the pulmonary vascular resistance (PVR) by non-invasive methods in patients with pulmonary hypertension, pulmonary thromboembolism, ischemic cardiopathy and valvular disease. The investigators have not found other studies which evaluate the PVR in elderly patients with COPD. The hypothesis is that in patients with COPD, the severity of obstruction, expressed by GOLD class, is associated with an increase of PVR.

Official Title
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Observational Study of Comparison of Echocardiographic Markers of Right Ventricular Function and Electrocardiographic Signs of Chronic Cor Pulmonale in Elderly Patient With COPD

Conditions
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Chronic Obstructive Pulmonary Disease, Pulmonary Hypertension, Cor Pulmonale

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: diagnosis of COPD stage II, III or IV according to the GOLD guidelines signed the informed consent Exclusion Criteria: ischemic cardiopathy severe valvular disease atrial fibrillation left bundle branch block

Ages Eligible for Study
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Minimum Age: 50 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| GOLD II<br>Will be included in this group the patients with COPD stage II | |
| GOLD III<br>Will be included in this group the patients with COPD stage III | |
| GOLD IV<br>Will be included in this group the patients with COPD stage VI. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| right ventricular function and GOLD stages | To compare right ventricular function, evaluated by a non-invasive method such as echocardiography, with the GOLD stages in chronic obstructive pulmonary disease (COPD) patients. | cross sectional | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Right ventricular function and FEV1. | Compare right ventricular function, evaluated by a non-invasive method such as echocardiography, tricuspid annulus plane systolic excursion (TAPSE),pulmonary artery systolic pressure (PAPs) and fractional area change (FAC), with the GOLD stages in chronic obstructive pulmonary disease (COPD) patients. | cross sectional | 
| ECG and echocardiography parameters of cor pulmonale | The correlation between right ventricular function and the electrocardiographic parameters of cor pulmonale. | cross sectional | 
| Right ventricle function and 6M-WT. | Evaluate the correlation between the hemodynamic indices of right ventricle and the six minute walking test (6M-WT). | cross sectional | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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COPD, PVR