Transvaginal Ultrasonography Guided Embryo Transfer

Study Overview
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Brief Summary
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to evaluate the value of using transvaginal ultrasound guided embryo transfer in obese patients undergoing in vitro fertilization.

Detailed Description
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The 800 participants with body mass index more than 30kg/m2 were randomly allocated to two groups of equal size using an automated web-based randomization system. The first group 400 patient undergoing the transabdominal-guided embryo transfer, the second group 400 patient undergoing transvaginal-guided embryo transfer.

Official Title
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Could Transvaginal Ultrasonography Guided Embryo Transfer Improves Pregnancy Outcome in Obese Patients Undergoing Intracytoplasmic Sperm Inoculation? Randomized Controlled Study

Conditions
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Infertility, Female

Intervention / Treatment
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* Procedure: transabdominal ultrasound guided embryo transfer
* Procedure: transvaginal ultrasound guided embryo transfer


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: BMI more than 35, good ovarian reserve, unexplained infertility more than 3 years. Exclusion Criteria: severe male factor of infertility,uterine factor of infertility excluded by ultrasonography and hysteroscopy ,ovarian endometrioma or patients with poly cystic ovary syndrome, obesity caused by abnormal endocrine function (thyroid or adrenal disorder)

Ages Eligible for Study
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Minimum Age: 25 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: randomized controlled trial
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: transabdominal ultrasound<br>400 obese female undergo transabdominal ultrasound guided embryo transfer | Procedure: transabdominal ultrasound guided embryo transfer<br>* 400 female with body mass index more than 30undergo transabdominal ultrasound guided embryo transfer<br>|
| Active Comparator: transvaginal group<br>400 obese female undergo transvaginal ultrasound guided embryo transfer | Procedure: transvaginal ultrasound guided embryo transfer<br>* 400 female with body mass index more than 30 undergo transvaginal ultrasound guided embryo transfer<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| clinical pregnancy rate' | the presence of at least one intrauterine gestational sac with viable fetus. | 4 weeks following embryo transfer | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| live birth rate | delivery of a living baby | immediately following delivery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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obesity, embryo transfer, invitro fertilization