Compliance and Tolerance to Oral AntiBiotherapy in Osteoarticular Infections (OTABIO)

Study Overview
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Brief Summary
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Bone and joint infections (BJI) are most often bacterial infections that can occur after surgery or de novo. They are rarely fatal in the short term, but are associated with significant morbidity, impaired quality of life and significant costs. Treatment of BJI is based on antibiotic therapy, often combined with surgery. Antibiotic therapy, at high doses, lasts a minimum of 6 weeks. It can be responsible for severe adverse effects. These characteristics (prolonged duration, multiple daily doses, and adverse effects) are known to negatively affect treatment adherence in general.

Official Title
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Compliance and Tolerance to Oral AntiBiotherapy in Osteoarticular Infections

Conditions
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Drug-Related Side Effects and Adverse Reactions, Treatment Adherence and Compliance

Intervention / Treatment
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* Other: Tolerance and adherence to oral antibiotics in patients managed for BJI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ≥ 18 years Diagnosis of osteoarticular infection Treatment with at least one oral antibiotic for a minimum expected duration ≥ 6 weeks with an expected end of treatment date Patient who was informed and did not object to participate in the study Exclusion Criteria: Treatment for BJI with oral antibiotic without end of treatment date treatment for BJI with parenteral antibiotic only patient who doesn't have a telephone number or who doesn't want to give it Adults subject to a legal protection measure Pregnant or breastfeeding women

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Tolerance and adherence to oral antibiotics in patients managed for BJI<br>Patients having a BJI treated by surgery and taking at least one oral antibiotic after the surgery | Other: Tolerance and adherence to oral antibiotics in patients managed for BJI<br>* Adherence and tolerance will be measured 6 weeks (S6) and 3 months (M3) after the surgery. The compliance data collected will be compared by two methods (electronic pill dispensers and questionnaire) Responses to the compliance questionnaire will be collected during a telephone interview by a member of the Croix-Rousse pharmacy at S6 and M3. The pill organizer data from S6 and M3 will be transferred to the software by a nurse. Patients will respond to a questionnaire about the tolerance on the consultation at S6 and M3.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percentage of doses taken at 6 weeks | Ratio of the number of doses taken over the theoretical number of doses to be taken over the period | At 6 weeks after surgery | 
| Percentage of doses taken at 3 months | Ratio of the number of doses taken over the theoretical number of doses to be taken over the period | at 3 months after surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Tolerance, Adherence, Antibiotic, BJI, adverse effect