Hangzhou Hospital Staff Cohort

Study Overview
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Brief Summary
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The Hangzhou Hospital Staff Cohort (HHSC) is a prospective cohort study among staffs from three hospitals located in Hangzhou, China, including the Hangzhou First People's Hospital, Hangzhou Women's Hospital, and Hangzhou Red Cross Hospital. Participants recruitment and baseline survey including anthropometric, lifestyle and clinical measurement, as well as biological samples collection are initiated in January 2021. Recruited hospital staff are followed up every year during the medical examination organized by their employer. The primary aim of the HHSC study is to investigate the prospective associations of diet, physical activities, sleep, and other lifestyle factors with the long-term metabolic health of the hospital staffs. The secondary aim of the HHSC study is to integrate multi-omics data including genomics, metabolomics, proteomics and microbiome by a machine learning algorithm, to probe into the complex mediating roles of gene, metabolism and gut microbiota linking lifestyle factors with metabolic health.

Official Title
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Hangzhou Hospital Staff Cohort

Conditions
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Diabetes Mellitus, Cardiovascular Diseases, Metabolic Syndrome

Intervention / Treatment
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* Other: diet, physical activities, sleep


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Participants aged 18 years or older Serving staffs of designated hospitals Exclusion Criteria: Participants with cancer Participants with other serious medical disorders

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: diet, physical activities, sleep|lifestyle factors|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of type 2 diabetes diagnosed as fasting blood glucose larger than 7.0 mmol/L | Fasting blood glucose is measured every year during follow-up | 3 years after enrollment | 
| Incidence of type 2 diabetes diagnosed as fasting blood glucose larger than 7.0 mmol/L | Fasting blood glucose is measured every year during follow-up | 6 years after enrollment | 
| Incidence of type 2 diabetes diagnosed as fasting blood glucose larger than 7.0 mmol/L | Fasting blood glucose is measured every year during follow-up | 9 years after enrollment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of body mass index | Participants' body weight and height was measured to calculate body mass index every year during follow-up | Change from baseline at 3 years | 
| Change of body mass index | Participants' body weight and height was measured to calculate body mass index every year during follow-up | Change from baseline at 6 years | 
| Change of body mass index | Participants' body weight and height was measured to calculate body mass index every year during follow-up | Change from baseline at 9 years |