CTO Registry From Insight of IVUS in Fuwai Hospital

Study Overview
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Brief Summary
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To evaluate the long-term outcome of chronic total occlusion (CTO) patients underwent contemporary percutaneous coronary intervention (PCI) techniques, we design this single-center, large-sample, prospective registry with five-year clinical follow-up, based on the intravascular ultrasound (IVUS) finding.

Detailed Description
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The study plan to include the patients with a CTO lesion in one of the three main epicardial coronary artery (diameter more than 2.5 mm) as the only target lesion. The CTO lesion is defined as 0 grade of thrombolysis in myocardial infarction (TIMI) flow with evidence of occlusion duration more than 3 months. All the PCI procedure will be performed by a group of certified operators in Fuwai Hospital, Beijing, China. All patients evaluate IVUS with automatic pullback (Opticross, Boston Scientific, US) performed after wire crossing. All the included patients are planned for five-year follow-up.

Official Title
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Contemporary Chronic Total Occlusion Percutaneous Coronary Intervention Registry From Insight of Intravascular Ultrasound in Fuwai Hospital

Conditions
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Coronary Heart Disease, Chronic Total Occlusion of Coronary Artery, Percutaneous Coronary Intervention, Intravascular Ultrasound

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Male or female patient >18 years old Thrombolysis in myocardial infarction trial (TIMI) 0 grade. Evidence of occlusion period more than 3 months. Patients eligible for PCI. Patients eligible for coronary artery bypass graft (CABG). Target vessel is one of the three main epicardial coronary arteries. Exclusion Criteria: Acute myocardial infarction with ongoing ST-elevation Target vessel is left main or graft vessel. Target vessel diameter < 2.5 mm. Other situations ineligible for PCI judged in clinical practice. Left ventricular ejection fraction <30%

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Target vessel revascularization | Any ischemic driven revascularization of the target vessel | 5-year follow-up after index PCI | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| All-cause death | Any cause of death | Within the first 1 month after PCI and during the 5-year follow-up | 
| Cardiac death | Cardiac death | Within the first 1 month after PCI and during the 5-year follow-up | 
| Myocardial infarction | Any myocardial infarction including perioperative MI | Within the first 1 month after PCI and during the 5-year follow-up | 
| Stroke | Ischemic or hemorrhagic stroke | Within the first 1 month after PCI and during the 5-year follow-up | 
| Major adverse cardiac and cerebrovascular events (MACCE) | Including all-cause death, myocardial infarction, stroke or any target vessel revascularization | Within the first 1 month after PCI and during the 5-year follow-up |