Visfatin Levels Before and After Periodontal Treatment

Study Overview
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Brief Summary
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The purpose of this study was to evaluate visfatin levels in different stages of periodontal diseases and health, moreover the effect of non-surgical periodontal therapy on visfatin levels in Gingival Crevicular Fluid (GCF) and Serum.

Detailed Description
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Total of 45 patients were divided into three groups based on their clinical and radiographical examination. Group 1 chronic periodontitis (n: 15), group 2 plaque induced gingivitis (n: 15) and group 3 Periodontal health (n: 15). GCF and serum samples were collected before treatment and 1, 3, 6 months after treatment and were assayed using enzyme linked immunosorbent assay kit.

Official Title
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Gingival Crevicular Fluid and Serum Levels of Visfatin in Periodontal Diseases Before and After Non-surgical Periodontal Treatment

Conditions
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Periodontal Diseases

Intervention / Treatment
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* Procedure: Non-surgical Periodontal Treatment.


Participation Criteria
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Eligibility Criteria
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Group 1 Inclusion Criteria: GI>1, PPD≥5mm, CAL≥5mm with alveolar bone loss radiographically. Systematically healthy patients Group 2 Inclusion Criteria: No alveolar bone and attachment loss Inflammation signs such as redness, edema and increased BOP levels, GI≥2, PPD≤3mm, CAL≤3mm. Systematically healthy patients Group 3 Inclusion Criteria: No bone and attachment loss, GI=0, PPD≤3mm, CAL≤3mm Systematically healthy patients Exclusion Criteria for all groups: Aggressive Periodontitis, Oral pathologies, Patients with any other systemic diseases, Pregnant women and those in the lactation period, Patients with smoking habit and taking medication Patients received periodontal therapy in last 6 months

Ages Eligible for Study
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Minimum Age: 25 Years
Maximum Age: 49 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group 1<br>Periodontal healthy | Procedure: Non-surgical Periodontal Treatment.<br>* Non-surgical periodontal therapy is an anti-infective therapy which includes both mechanical and chemotherapeutic approaches to minimize or eliminate microbial biofilm, the primary etiology of gingivitis and periodontitis<br>|
| Group 2<br>Gingivitis, Non-surgical Periodontal Treatment | Procedure: Non-surgical Periodontal Treatment.<br>* Non-surgical periodontal therapy is an anti-infective therapy which includes both mechanical and chemotherapeutic approaches to minimize or eliminate microbial biofilm, the primary etiology of gingivitis and periodontitis<br>|
| Group 3<br>Chronic Periodontitis, Non-surgical Periodontal Treatment | Procedure: Non-surgical Periodontal Treatment.<br>* Non-surgical periodontal therapy is an anti-infective therapy which includes both mechanical and chemotherapeutic approaches to minimize or eliminate microbial biofilm, the primary etiology of gingivitis and periodontitis<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Visfatin levels: Change after periodontal treatment both in serum and GCF |  | baseline, 1, 3 and 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Visfatin, GCF, serum, Non-surgical Periodontal Treatment.