Analgesic Effect of Intra-articular Dexamethasone and Dexamethasone Added to Bupivacaine in Interscalene Brachial Plexus

Study Overview
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Brief Summary
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the aim of this study was to investigate the analgesic efficacy of intra articular dexamethasone administration for arthroscopic shoulder surgery.

Detailed Description
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shoulder surgery can be very painful and interscalene brachial plexus block is the gold standard in the management of acute pain after shoulder surgery. various local anaesthetic mixtures can be used to prolong local anaesthesia duration and epinephrine , opioids and dexamethasone are frequently used for this purpose. dexamethasone has also been found the prolong the duration of lidocaine axillary blocks and intravenous regional anaesthesia. intraarticular administration of medicines can be used for management of joint pain and opioids , local anaesthetics and dexamethasone are used for this purpose.In addition, there are no studies available to compare the different treatment methods used in clinical practice directly.

Official Title
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Phase 4 Study of Comparison of Postoperative Analgesic Effect of Intra-articular Dexamethasone and Dexamethasone Added to Bupivacaine in Interscalene Brachial Plexus Blockade for Arthroscopic Shoulder Surgery

Conditions
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Postoperative Pain

Intervention / Treatment
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* Procedure: intraarticular dexamethasone
* Procedure: interscalene dexamethasone
* Procedure: serum phsyologic


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: between 18-65 years arthroscopic shoulder surgery no known allergies to drugs ASA 1-2 patients Exclusion Criteria: history of diabetes history of chronic pain treatment pregnancy severe bronchopulmonary disease systemic glucocorticoid use

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: intraarticular dexamethasone<br>interscalene brachial plexus block was preoperative performed 30 ml 0.5 % bupivacaine+ 2 ml serum phsyologic and after surgery 2 ml 8 mg dexamethasone+ 8 ml serum phsyologic administration for intraarticular | Procedure: intraarticular dexamethasone<br>* 2ml 8 mg dexamethasone administration for intraarticular<br>* Other names: dekort;|
| Active Comparator: interscalene dexamethasone<br>interscalene brachial plexus was preoperative performed 30 ml 0.5 % bupivacaine added 2 ml 8mg dexamethasone and after surgery 10 ml serum phsyologic administration for intraarticular | Procedure: interscalene dexamethasone<br>* 2ml 8 mg dexamethasone administration interscalene brachial plexus added 30 ml 0.5 % bupivacaine<br>* Other names: dekort;|
| Placebo Comparator: serum phsyologic<br>interscalene brachial plexus block was preoperative performed 30 ml 0.5 % bupivacaine+ 2ml serum phsyologic and after surgery 10 ml serum phsyologic administration for intraarticular | Procedure: serum phsyologic<br>* interscalene brachial plexus block was preoperative performed 30 ml 0.5 % bupivacaine+ 2ml serum phsyologic and after surgery 10 ml serum phsyologic administration for intraarticular<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| analgesic consumption | morphine consumption (patient controlled analgesia procedure) was recorded | postoperative 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| visual analog scale | Visual analog scale on rest and movement was recorded | postoperative 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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dexamethasone, intraarticular injection, interscalene brachial plexus block