Effect of Oral Collagen Tripeptide on Skin Moisture and Wrinkles in Adult Women

Study Overview
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Brief Summary
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Comparison of a randomized, double-blind, and control-group study for the effect of oral ingestion of collagen tripeptides derived from fish on dermal moistures and wrinkles body fat reduction in participants

Detailed Description
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The aim is to investigate the effect of oral ingestion of collagen tripeptides derived from fish on dermal moistures and wrinkles body fat reduction in participants by a randomized, double-blind, and control-group study.

Official Title
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Effect of Oral Collagen Tripeptide on Skin Moisture and Wrinkles in Adult Women

Conditions
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Skin Manifestations, Skin Wrinkling

Intervention / Treatment
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* Dietary Supplement: CTP
* Dietary Supplement: placebo (starch)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: - > = 4 of Tewameter Exclusion Criteria: Within the last 6 months, took skin surgery including cosmetic purpose Diabetic patients with poor glycemic control with a fasting blood glucose of 160 mg/dl or more Creatinine levels: more than twice the normal upper limit AST (GOT) or ALT (GPT) levels: more than twice the normal upper limit Uncontrolled hypertension sun allergy or sensitive skin functional cosmetics that affect dermal moistures and wrinkles within the last 3 months. If you have participated or are planning to participate in another clinical trial within the past month Alcohol abuser If they are pregnant or lactating or have a pregnancy plan during the clinical trial Those with allergic reactions to the constituent food Any person deemed inappropriate by the researcher for other reasons

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: CTP group<br>1,000 mg of collagen tripeptide (CTP) was orally administered per day for 12 weeks. | Dietary Supplement: CTP<br>* 1,000 mg of CTP was orally administered per day for 12 weeks.<br>|
| Placebo Comparator: Control group<br>1,000 mg of placebo (starch) was orally administered per day for 12 weeks | Dietary Supplement: placebo (starch)<br>* placebo (starch)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| changes in Transepidermal Waterloss by Tewameter | comparison between baseline, after 6 weeks, and after 12 weeks | baseline, after 6 weeks, and after 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| changes in skin wrinkling indices by Visiometer | comparison between baseline, after 6 weeks, and after 12 weeks | baseline, after 6 weeks, and after 12 weeks | 
| skin elasticity by Cutometer | comparison between baseline, after 6 weeks, and after 12 weeks | baseline, after 6 weeks, and after 12 weeks | 
| changes in hydration level of the skin surface by Corneometer | comparison between baseline, after 6 weeks, and after 12 weeks | baseline, after 6 weeks, and after 12 weeks |