DNI Values After Periodontal Treatment

Study Overview
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Brief Summary
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The study included 70 systemically healthy individuals, as a test group of 35 patients with Stage 3, Grade A periodontitis and a control group of 35 individuals with no periodontal disease. Blood samples were taken for the examination of DNI, white blood cells (WBC), immature granulocytes (IG), procalcitonin, C-reactive protein (CRP), lymphocyte count and neutrophil count. For the patients with periodontitis, blood sample assays were repeated 3 months after NSPT.

Detailed Description
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The role of the Delta Neutrophil Index (DNI) in the pathogenesis and follow-up of periodontal disease has not been comprehensively documented. The study included 70 systemically healthy individuals, as a test group of 35 patients with Stage 3, Grade A periodontitis and a control group of 35 individuals with no periodontal disease. Blood samples were taken for the examination of DNI, white blood cells (WBC), immature granulocytes (IG), procalcitonin, C-reactive protein (CRP), lymphocyte count and neutrophil count. For the patients with periodontitis, blood sample assays were repeated 3 months after NSPT.

Official Title
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Can Delta Neutrophil Index Values Predict the Success of Periodontal Treatment in Patients With Periodontitis?

Conditions
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Periodontitis, Periodontal Inflammation, Inflammatory Response

Intervention / Treatment
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* Other: Only routine non-surgical periodontal treatment was applied to the patients.


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients diagnosed with periodontitis, Must have more than 20 teeth in the mouth, be between the ages of 18-65 Exclusion Criteria: Patients were excluded from the study if they had any systemic disease, were active smokers, were pregnant or breastfeeding, had used any antibiotic or anti-inflammatory drug in the last 6 months, had received any periodontal treatment in the last 6 months.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Kahramanmaraş Sütçü İmam University<br>Only routine non-surgical periodontal treatment was applied to the patients. | Other: Only routine non-surgical periodontal treatment was applied to the patients.<br>* The study included 70 systemically healthy individuals, as a test group of 35 patients with Stage 3, Grade A periodontitis and a control group of 35 individuals with no periodontal disease. Blood samples were taken for the examination of DNI, white blood cells (WBC), immature granulocytes (IG), procalcitonin, C-reactive protein (CRP), lymphocyte count and neutrophil count. For the patients with periodontitis, blood sample assays were repeated 3 months after non-surgical periodontal treatment<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Can Delta Neutrophil Index values predict the success of periodontal treatment in patients with periodontitis | We expect a decrease in the Delta Neutrophil Index values after non-surgical periodontal treatment. | 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Neutrophil-lymphocyte ratio (NLR) values after non-surgical periodontal treatment. | We expect a decrease in the neutrophil-lymphocyte ratio (NLR) values after non-surgical periodontal treatment. | 12 weeks |