Follow-up of Long-term Renal Function After Acute Kidney Injury in ICU

Study Overview
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Brief Summary
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Acute kidney injury (AKI) involves poor prognosis in ICU patients. The renal prognosis at long term is unknown. The study will determine chronic kidney injury incidence and quality of life, five years after AK during ICU stay.

Detailed Description
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Prospective study. All patients who participated ELVIS study (clinical trials: 00875069) can be enrolled in SURIA. Patients are contacted by telephone. Investigator delivery objective and honest information. If patients accepts the study, answers will be collected. Collected data are: creatinine serum, two surveys (quality of life and activities of daily living), date of onset of renal replacement therapy.

Official Title
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A Study on the Follow-up of Long-term Renal Function After Acute Kidney Injury in ICU

Conditions
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Acute Kidney Injuries, Quality of Life, Chronic Kidney Disease, Renal Replacement Therapy

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ICU Patients included in ELVIS study, AKI requiring renal replacement therapy Length of ICU stay ≥ 48h Exclusion Criteria: Pregnant or nursing woman's job

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients who were included in ELVIS study<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| incidence of chronic kidney disease | incidence of chronic kidney disease in patients who had an acute kidney injury during their ICU stay and requiring an renal replacement therapy | 5 years after the first acute kidney injury requiring renal replacement therapy | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| severity of CKD according to the International Classification of Chronic Kidney Disease | Kidney function will be measured by creatinine serum or chronic dialysis or kidney transplantation | 5 years after the first acute kidney injury requiring renal replacement therapy | 
| impact of the renal replacement therapy on long-term renal function | Intermittent or continuous renal replacement therapy. Data collected in the database from ELVIS study. Kidney function will be measured by creatinine serum or chronic dialysis | 5 years after the first acute kidney injury requiring renal replacement therapy | 
| quality of life | Quality of life will be assessed with the Q5D score | 5 years after the first acute kidney injury requiring renal replacement therapy | 
| Activities of daily living | Activities of daily living will be assessed with the Katz adjustment scales | 5 years after the first acute kidney injury requiring renal replacement therapy | 
| Mortality | Mortality | 5 years after the first acute kidney injury requiring renal replacement therapy | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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acute kidney injury, quality of life, Renal replacement therapy, Intensive care unit