Tissue Characterization With Hyperspectral Imaging (HSI)

Study Overview
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Brief Summary
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Hyperspectral Imaging (HSI) is a contact free method to analyse the from the tissue reflected light in the range of 500-1000nm. Aim of the study is to identify special reflex patterns to identify special tissue

Detailed Description
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This HSI-camera provides hyperspectral images with a high spectral resolution (5 nm) in the visible and near infrared range (500-1000 nm). A RGB image and 4 false color images that represent physiologic parameters are intraoperatively provided by an analysis software. But after the procedure all spectral datasets could be investigated. To analyse and differentiate the different tissues, a catalog database is needed of all tissues including Tumors.

Official Title
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Tissue Characterisation With Hyperspectral Imaging Methods

Conditions
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Tissue Perfusion, Tumor, Inflammation, Inflammatory Bowel Diseases

Intervention / Treatment
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* Procedure: Hyperspectral imaging
* Diagnostic Test: Lactate acid measurement
* Diagnostic Test: pathological examination


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All patients with surgical procedure Exclusion Criteria: inability to consent

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Hyperspectral imaging<br>diagnostic hyperspectral imaging of the human tissue an correlation with local blood parameters and local pathological examination | Procedure: Hyperspectral imaging<br>* Photos were taken with the hyperspectral camera of the human tissue<br>* Other names: Marking of the target region (Suture/Clip/ink);Diagnostic Test: Lactate acid measurement<br>* At the marked regions of the specimen, a lactate acid measurement was performed.<br>Diagnostic Test: pathological examination<br>* At the marked regions of the specimen, the pathological examination was performed.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Tumor detection with HSI | Due to the non-invasive diagnostics with the HSI camera, tumor tissue can be distinguished from healthy tissue. | direct during the Operation (ca. 15-20 Minutes) | 
| Tissue recognition with HSI | different tissues can be differentiated from each other with HSI | after the operation within 24 hours | 
| Inflammatory classification with HSI | Classification of the grade of the inflammation e.g. in IBD | after the operation within 24 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Tissue perfusion | Tissue perfusion in the upper and lower tissue layers measured with the HSI Camera | direct during the Operation (ca. 10-15 Minutes) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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hyperspectral imaging, tissue detection, tumor detection, infammatory bowel disease, colorectal cancer