PET Imaging and Bariatric Surgery

Study Overview
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Brief Summary
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The purpose of this study is to look at certain areas of the brain that are related to addictive behaviors, such as overeating. These areas are called 'dopamine type 2 receptors' (DRD2/3) and other studies have shown that obese people have less of these. We propose that low DRD2/3 availability seen in morbidly obese subjects will change with weight loss associated with bariatric surgery.

Detailed Description
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The purpose of this study is to look at certain areas of the brain that are related to addictive behaviors, such as overeating. These areas are called 'dopamine type 2 receptors' (DRD2/3) and other studies have shown that obese people have less of these. We propose that low DRD2/3 availability seen in morbidly obese subjects will change with weight loss associated with bariatric surgery.

Official Title
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PET Imaging and Bariatric Surgery

Conditions
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Obesity, Morbid

Intervention / Treatment
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* Drug: F-18 (fallypride)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Ages 18-60 years BMI equal to or greater than 40, or equal to or greater than 35 if there are 2 or more co-morbidities Weight less than 350 pounds Exclusion Criteria: History of substance abuse,including but not limited to alcohol, cocaine, marijuana, heroin, nicotine History of psychiatric disorders Use of any antidepressants or psychotropics in the past 12 months Diabetes Mellitis Positive pregnancy test Any condition felt by the PI or co-investigators to interfere with the individual's ability to complete the study Subjects on medications for the last 3 months, such as sibutramine, which could affect the quality of the study, as determined by the PI Inability to travel to Nashville, TN four times

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: F-18 (fallypride)<br>Subjects undergoing bariatric surgery will have Positron Emission Tomography (PET) scans of their brains using F-18 (fallypride), a dopamine type 2/3 (DA D2/3) receptor radioligand whose binding is sensitive to competition with endogenous dopamine, before and after the operation. | Drug: F-18 (fallypride)<br>* Subjects undergoing bariatric surgery will have Positron Emission Tomography (PET)scans of their brains using the radioligand fallypride before and after the operation.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Regional DRD2/3 Binding Percent Changes After Bariatric Surgery |  |  7 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Obesity, Addiction, PET imaging