Effects of Essence of Chicken on Physical Fatigue, Working Memory and Attention

Study Overview
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Brief Summary
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In Southeast Asia, Essence of Chicken, a chicken-meat-extract, is a popular beverage and is consumed as a traditional remedy for several ailments, including the use as a nutritional supplement for sickness, enhancement of mental efficiency, and recovery from mental fatigue. While the elderly use it as a nutritional supplement, students use it for relief from anxiety during exam times. The present study is conducted in order to assess the effects of BEC on various physical and mental parameters including physical fatigue, working memory and attention, mood and stress, in comparison to placebo.

Official Title
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Effects of the Supplementation of Essence of Chicken on Physical Fatigue and Brain Functions Such as Working Memory and Attention Among Healthy Adults

Conditions
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Healthy Subjects, Fatigue

Intervention / Treatment
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* Dietary Supplement: Essence of Chicken
* Dietary Supplement: Placebo (Energy matched)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Normal BMI Not continuously taken Essence of Chicken for the last 3 months Physical and psychological fatigue inclusion criteria/test/cutoff using CFQ (where individuals' CFQ scores 4 or above) Exclusion Criteria: Suffering from chronic or malignant diseases e.g. cancer, heart, liver, renal or other metabolic diseases. Any psychiatric or neurological disease Pregnant and lactating women Subjects participated in any investigational drug trial within 4 weeks before screening Consumption of food supplement in the previous 2 weeks Professional athletes Subjects with recent lifestyle changes in the past 4 weeks History of allergy to chicken meat and seafood

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: 1 bottle<br> | Dietary Supplement: Essence of Chicken<br>* Brand's Essence of Chicken (BEC) is produced via a water extraction process from chicken meat for several hours under high-temperature, followed by centrifugation to remove fat and cholesterol, vacuum concentration to 3- to 4-fold, sterilization by high temperature and pressure before bottling. This kind of chicken essence is rich in protein, and low in sugar and fat, conveniently available and consumable, and easy for household storage.<br>|
| Active Comparator: 2 bottles<br> | Dietary Supplement: Essence of Chicken<br>* Brand's Essence of Chicken (BEC) is produced via a water extraction process from chicken meat for several hours under high-temperature, followed by centrifugation to remove fat and cholesterol, vacuum concentration to 3- to 4-fold, sterilization by high temperature and pressure before bottling. This kind of chicken essence is rich in protein, and low in sugar and fat, conveniently available and consumable, and easy for household storage.<br>|
| Placebo Comparator: Placebo<br> | Dietary Supplement: Placebo (Energy matched)<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fatigue-vitality | Psychometric tests SF-36 (score 100%) | 4 weeks | 
| Physical fatigue | Chalder Fatigue Questionnaire (score 0-33) | 4 weeks | 
| Attention | Stroop (mean latency and proportion correct) | 4 weeks | 
| Sustained attention | Sustained Attention to Response Task (mean latency and % of correct trials) | 4 weeks | 
| Working memory | Digit Span test (Maximal FORWARD digit span and Maximal BACKWARD digit span, etc) | 4 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mood | POMS brief is used as a psychometric test to measure mood (6 domains). | 4 weeks | 
| Stress | DASS is used as a psychometric test to measure stress (score 0-42). | 4 weeks | 
| Adverse effects | Comparison of adverse events on IP and placebo groups. | 4 weeks |