Power Spectral Analysis of EEG During Equi-MAC Inhalation Anesthesia

Study Overview
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Brief Summary
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The purpose of this clinical trial is to compare hypnotic effect of sevoflurane and desflurane at equal minimum alveolar concentrations using power spectral analysis of the electroencephalogram.

Detailed Description
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Volatile anesthetics vary in their relative hypnotic potency. Recent studies demonstrated that equi-minimum alveolar concentration of various volatile anesthetic agents may produce different spectral entropy or bispectral index values. However, there were no studies that demonstrate the difference of hypnotic potency using power spectral analysis of electroencephalographic signals (e.g., spectral edge frequency 95%, total power, % value of each bandage). The purpose of this clinical trial is to compare hypnotic effect of sevoflurane and desflurane at equal minimum alveolar concentrations using power spectral analysis of the electroencephalogram.

Official Title
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Power Spectral Analysis of the Electroencephalogram During Equi-MAC Sevoflurane vs. Desflurane Anesthesia: A Randomized Controlled Trial

Conditions
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Anesthesia

Intervention / Treatment
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* Drug: Sevoflurane
* Drug: Desflurane


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients undergoing arthroscopic knee surgery under general anesthesia using volatile anesthetics patients with american society of anesthesiologist physical status I, II patients aged 19-65 years patients obtaining written informed consent Exclusion Criteria: patients with a history of any psychiatric or neurological disease patients who had received any medication affecting the central nervous system patients who had received medication affecting the sympathetic or parasympathetic nervous systems patients undergoing tracheal intubation for airway management pregnant women

Ages Eligible for Study
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Minimum Age: 19 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Sevoflurane<br>Anesthesia was maintained with sevoflurane. | Drug: Sevoflurane<br>* Anesthesia was maintained with sevoflurane in patients undergoing arthroscopic knee surgery under general anesthesia. End-tidal concentration of sevoflurane was maintained at age-corrected 1 minimum alveolar concentration throughout the study period.<br>* Other names: SEVO;|
| Experimental: Desflurane<br>Anesthesia was maintained with desflurane. | Drug: Desflurane<br>* Anesthesia was maintained with desflurane in patients undergoing arthroscopic knee surgery under general anesthesia. End-tidal concentration of desflurane was maintained at age-corrected 1 minimum alveolar concentration throughout the study period.<br>* Other names: DES;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Spectral edge frequency 95% value | EEG variables were measured after meeting steady-state anesthesia of 1 MAC. | During about 30 min study period | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Bispectral index | Bispectral index measurements were made after meeting steady-state anesthesia of 1 MAC. | During about 30 min study period |