A Training of the Rhythmic Skills With a Serious Game to Improve Gait and Cognitive Abilities in Parkinson's Disease

Study Overview
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Brief Summary
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This project aims at assessing the opposite relation, namely the effect of a training of the general timing abilities on gait in Parkinson's disease. Timing rehabilitation will be done by the means of a serious game. Serious games are more and more used to improve the compliance and the efficacy of reeducaiton programs. Overall, we propose to test a low-cost tool for rehabilitation.

Detailed Description
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Auditory rythmic cueing is a method consisting in presenting a regular auditory stimulus (metronom or music) when someone is walking. It is known to improve gait in pathologies such as Parkinson's disease. It has also an effect on general timing abilities (e.g. tapping the beat of the music). This project aims at assessing the opposite relation, namely the effect of a training of the general timing abilities on gait in Parkinson's disease. Timing rehabilitation will be done by the means of a serious game. Serious games are more and more used to improve the compliance and the efficacy of reeducaiton programs. Overal, we propose to test a low-cost tool for rehabilitation.

Official Title
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Rhythm Game Park: a Training of the Rhythmic Skills With a Serious Game to Improve Gait and Cognitive Abilities in Parkinson's Disease

Conditions
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Parkinson Disease

Intervention / Treatment
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* Other: Rhythm workers training Perceptive timing
* Other: Rhythm workers training sensorimotor timing
* Other: No Rhythm workers training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age < 18 good understanding of the nature, the goal and the methodology of the study signing of the informed consent being insured with a social security Diagnostic of idiopathic Parkinson's disease following the Queen Square Brain Bank (Hughes, 1992) Hoehn et Yahr between 2 and 3 mild to moderate walk and speech deficits (Item MDS-UPDRS) stable therapy one month before inclusion for all the duration of the study Exclusion Criteria: Atypic Parkinson Syndrom (oculomotor troubles, early falls, hallucinations, MoCA<20, early dysautonomy) dystonia ou dyskinesia preventing from using a tablet (item MDS-UPDRS4.2 >2) Unable to move without help (walking stick, walker, wheelchair) (item MDS-UPDRS 2.12 >2) adult protected by law deprivation of liberty High propability of non compliance to the protocol pregnant women, nursing women moderate to severe auditory trouble Severe walk fluctuations item MDS-UPDRS 4.4 >2) Pacemaker or neurosensorial device or heart defebrillator Cochlear implants ferromagnetic external bodies claose to the brain Metallic prothesis agitated, non cooperative patient claustrophobic patient neuro-surgical shunt valves dental appliance

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: No training<br>Parkinsonian Patients with no Rhythm Workers training perceptive timing and senrorimotor timing | Other: No Rhythm workers training<br>* No training<br>|
| Other: Perceptive timing training<br>Parkinsonian Patients with Rhythm Workers training perceptive timing | Other: Rhythm workers training Perceptive timing<br>* Perceptive timing training<br>|
| Other: Sensorimotor timing training<br>Parkinsonian Patients with Rhythm Workers training sensorimotor timing | Other: Rhythm workers training sensorimotor timing<br>* Sensorimotor timing training<br>|
| Other: Healthy volunteers<br>Healthy people with Rhythm Workers training perceptive timing | Other: Rhythm workers training Perceptive timing<br>* Perceptive timing training<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rythmic capacities | Evaluate the effect of the training of the rythmic capacities (Sensorimotor timing abilities) on the walk and the speak | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| cognitive functions | Evaluate the cognitive functions by Neurospsychologic tests | 3 months | 
| Mesure of the neural reorganisation | Evaluate the structure et connectivity by MRI | 3 months |