Effect of Volume and Type of Fluid on Postoperative Incidence of Respiratory Complications and Outcome (CRC-Study)

Study Overview
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Brief Summary
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Intraoperative intravenous fluid management practice varies greatly between anesthesiologists. Postoperative fluid based weight gain is associated with major morbidity. Postoperative respiratory complications are associated with increased morbidity, mortality and hospital costs. The literature shows conflicting data regarding intraoperative fluid resuscitation volume. No large-scale studies have focused on intraoperative fluid management and postoperative respiratory dysfunction. Hypotheses: Primary - Liberal intraoperative fluid resuscitation is associated with an increased risk of 30 day mortality Secondary - Liberal intraoperative fluid resuscitation is associated with increased likelihood of postoperative respiratory failure, pulmonary edema, reintubation, atelectasis, acute kidney injury and peri-extubation oxygen desaturation.

Official Title
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Effect of Volume and Type of Fluid on Postoperative Incidence of Respiratory Complications and Outcome (CRC-Study)

Conditions
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Pneumonia, Hypoxia, Acute Kidney Injury, Respiratory Failure, Acute Respiratory Failure Requiring Reintubation, Pulmonary Edema

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Ages 18 upwards Tracheally intubated at the beginning of the procedure and extubated at the end of the procedure Exclusion Criteria: Cases where the subject had additional surgeries within the previous four weeks Ages under 18

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality | Mortality within 30 days of surgery | within 30 days after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative pulmonary complications | The incidence of a diagnosis of pneumonia, respiratory failure, atelectasis or pulmonary edema within 3 days after extubation in the operating room. Cases where these diagnoses were present on the day before surgery were not counted. | 3 days after surgery | 
| Acute Kidney Injury | A Creatinine increase of >0.3mg/dl or 50% from baseline (Creatinine value closest recorded to surgery but within 30 days of surgery) to maximum value measured within 48 hours postoperatively or an ICD-9 diagnosis of AKI within 7 days of surgery but not within 30 days prior to surgery | within 48 hours of surgery | 
| Post-extubation oxygen desaturation | One or more minutes with a blood oxygen saturation below 90% during the first ten minutes after extubation | within the first 10 minutes after extubation | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Fluids, Intraoperative, Respiratory, Outcomes, Surgery, Anesthesia