Effect of Paravertebral Muscle Fat Infiltration on Rocuronium Use in Lumbar Surgery

Study Overview
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Brief Summary
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To investigate the effect of different degrees of fat infiltration on rocuronium use in lumbar surgery was monitored by trapezius muscle relaxation.

Detailed Description
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Select the patients who will receive posterior lumbar surgery in the Second Hospital of Shanxi Medical University. According to the classification criteria of fat infiltration, it will be divided into three groups: mild, moderate and severe. This study will pump and titrate rocuronium bromide under the monitoring of muscle relaxation during the operation, record the dosage of rocuronium bromide and the duration of pump injection, and evaluate its clinical effect. Postoperative results include the use and clinical effect of rocuronium, which will be counted after the trial.

Official Title
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Effect of Paravertebral Muscle Fat Infiltration on Rocuronium Use in Lumbar Surgery

Conditions
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Spinal Stenosis Lumbar

Intervention / Treatment
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* Drug: Rocuronium Bromide


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age: 18-65; ASA grade I-II; no significant cardiopulmonary disease; no history of surgery in the corresponding surgical area; no coagulopathy. Exclusion Criteria: refusal to participate by the present experimenter; those with severe cardio-cerebrovascular disease, severe hepatic and renal dysfunction; taking medications affecting the neuromuscular junction; area of monitoring site for skin breakers; patients with intraoperative bleeding, anaphylactic shock, or other serious complications; patients requiring intraoperative neurophysiological monitoring (including sensory, motor evoked potentials).

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Mild fat infiltration<br>Fat infiltration rate is less than 30% | Drug: Rocuronium Bromide<br>* 0.6 mg/kg rocuronium was injected intravenously, and rocuronium was pumped during operation to maintain deep muscle relaxation<br>* Other names: Midazolam, propofol, etomidate and remifentanil;|
| Experimental: Moderate fat infiltration<br>Fat infiltration rate is 30% 50% | Drug: Rocuronium Bromide<br>* 0.6 mg/kg rocuronium was injected intravenously, and rocuronium was pumped during operation to maintain deep muscle relaxation<br>* Other names: Midazolam, propofol, etomidate and remifentanil;|
| Experimental: Server fat infiltration<br>Fat infiltration rate is greater than 50% | Drug: Rocuronium Bromide<br>* 0.6 mg/kg rocuronium was injected intravenously, and rocuronium was pumped during operation to maintain deep muscle relaxation<br>* Other names: Midazolam, propofol, etomidate and remifentanil;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| use of rocuronium bromide | average dosage | Perioperative period | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The general condition of the paraspinal muscle | Fat infiltration rate | Perioperative period |