Impact of Periodontal Bacteria at Baseline on the Effectiveness of Periodontal Therapy

Study Overview
=================
Brief Summary
-----------------
In light of the controversy that are already approved but that however still exists regarding the efficacy and influence of the protocols for the management of Periodontitis, the aim of this study was to evaluate, at 6 months follow-up, the post-treatment clinical parameters and immunological and gingival microbial profiles in patients with periodontitis, treated by either SRP in addition to full mouth scaling or quadrant scaling

Detailed Description
-----------------
This trial was conducted in accordance with the World Medical Association's Declaration of Helsinki of 1975, and reviewed in 2008. The local ethical committee of the University of Messina approved the study protocol and each patient was carefully informed about the possible inherent risks of the study and provided their informed written consent 102 patients, , aged 27 to 65 (mean age 44.2) were assessed for eligibility. In all subjects, subgingival plaque was acquired from 4 separate proximal sites at 180 days after therapy.

Official Title
-----------------
Impact of Periodontal Bacteria at Baseline on the Effectiveness of Periodontal Therapy Outcomes in Patients With Periodontitis: A Prospective Clinical and Microbial Study

Conditions
-----------------
Periodontitis

Intervention / Treatment
-----------------
* Procedure: Scaling and root planing


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: good condition of general health, a minimum of 2 teeth for each quadrant with a Pocket Depth (PD) ranging from 4-6 mm, no involvement of the furcation, a minimum of a six teeth per quadrant, respectively. Exclusion Criteria: periodontal therapy during the last 12 months, assumption of antibiotics during the last 6 months, pregnancy, any systemic condition which might affect the effects of the study treatment, previous or current radiation or immunosuppressive therapies, use of mouthwash containing antimicrobials during the previous 3 months, no use of hormonal contraceptives, medication by anti-inflammatory and immunosuppressive drugs, previous history of hard-drinking, smoking, class II and III tooth mobility.

Ages Eligible for Study
-----------------
Minimum Age: 30 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Periodontitis quadrant<br>Patients undergo non surgical quadrant scaling and root planing | Procedure: Scaling and root planing<br>* Full mouth or quadrant SRP<br>|
| Active Comparator: Periodontitis full mouth<br>Patients undergo non surgical full mouth scaling and root planing | Procedure: Scaling and root planing<br>* Full mouth or quadrant SRP<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical Attachment level | Analysis of reduction of clinical attachment level | 180 days |