Can Diffusion Tensor Imaging (DTI) of the Optic Ways Contributes to Predict the 6 Months Prognosis of Optic Neuritis (ON)?

Study Overview
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Brief Summary
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Can diffusion tensor imaging (DTI) of the optic ways contributes to predict the 6 months prognosis of Optic Neuritis (ON)?

Official Title
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Can Diffusion Tensor Imaging (DTI) of the Optic Ways Contributes to Predict the 6 Months Prognosis of Optic Neuritis (ON)?

Conditions
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Optic Neuritis

Intervention / Treatment
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* Device: MRI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age from 18 to 55 years old Clinically suspected optic neuritis defined as a sudden decrease of the visual acuity and/or a damage to the field of vision and/or a defect of the colour vision and/or retro-orbital pain with a relative afferent pupillary defect (except if the optic neuropathy is bilateral or symmetrical), in the absence of a severe retinal macular pathology, and in the absence of a toxic or iatrogenic intake (ethambutol, vfend) Clinical optic neuritis duration < 15 days First episode of an inflammatory ON No corticosteroids in the month before Indication to a corticosteroid therapy at high dose to cure the felt symptomatology Retinal nerve fibre layer (RNFL) thickness upper 75 µm at initial stage Isolated ON, multiple sclerosis or NMO (Neuro Myelitis Optica) - SD (Spectrum Disorder) context Having signed informed consent for participating in the study Exclusion Criteria: Contra-indication to MRI Cardiac pacemaker or defibrillator implant Neurosurgical clips Cochlear implants Intra-orbital or encephalic foreign bodies Stents implanted since less than 4 weeks and osteosynthesis equipment implanted since less than 6 weeks Claustrophobia Persons subject to major legal protection (safeguarding justice, guardianship, trusteeship), persons deprived of liberty Eye examination suggests a pre-existing eye abnormality that could affect the visual function (amblyopia, strong myopia…) Pregnant or breastfeeding women

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Interventional Model Description: Interventional pilot study with minimal risks and constraints, descriptive, prospective, monocentric
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Patient with Optic Neuritis<br> | Device: MRI<br>* MRI in diffusion tensor (DTI : Diffusion Tensor Imaging)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Study of DTI markers in the assessment of the visual prognosis at 6 months of an inflammatory NO based on RNFL thickness (< ou > 75 µm) | MRI | Month 6 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Study of DTI markers in the assessment of the visual prognosis at 6 months of an inflammatory NO based on visual acuity and/or sensible damage to the field of vision | MRI | Month 6 | 
| Comparison of the structural anomalies detected in DTI to the standard morphological MRI (Coronal T2 Fat-Sat MRI and T1 Gadolinium) for ON | MRI | Month 6 |