Risk Prediction for Alzheimer Dementia With Brain Imaging and Genetics

Study Overview
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Brief Summary
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The purpose of this study is to learn about how trauma, posttraumatic stress disorder (PTSD), and mild traumatic brain injury that can occur during deployment affect the brain. The investigators also want to learn how PTSD and mild traumatic brain injury can affect the chance of developing Alzheimer disease later in life. The investigators will study this by using magnetic resonance imaging and positron emission tomography scans to obtain pictures of the brain.

Official Title
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Risk Prediction for Alzheimer Dementia With Brain Imaging and Genetics

Conditions
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Alzheimer Dementia, Posttraumatic Stress Disorder, Traumatic Brain Injury

Intervention / Treatment
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* Device: MRI
* Device: PET
* Device: 18F-Florbetapir
* Device: Radioligand 18F-AV-1451


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 18 to 65 Previously enrolled in studies of OEF/OIF veterans by the same investigators Free of implanted metal objects or mental shards in eyes Fluent in English and capable of consenting Exclusion Criteria: Axis I disorders other than Major Depressive Disorder or PTSD Current substance abuse or lifetime substance dependence (other than nicotine) High risk for suicide Claustrophobia Neurological disorders Learning disability or developmental delay Major medical conditions

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Healthy volunteers<br>Volunteers with no trauma history | Device: MRI<br>* You will be asked to undergo a scan of your brain called an MRI. The MRI scan can measure the functioning of your brain.<br>Device: PET<br>* You will be asked to undergo a scan of brain called a positron emission tomography (PET) scan. The PET scan is a test that uses radioactive glucose (sugar) and a computer to create images of how your brain is functioning. Abnormal cells in the body use glucose at a different rate than normal cells and this allows the scanner to create a detailed picture of how your body is working.<br>Device: 18F-Florbetapir<br>* At the Duke University PET Center you will be in a quiet dimly lit space with only ambient room sound, with your eyes open and ears unplugged. Your safety will be monitored by a physician and nurse. 18F-florbetapir will be administered to you as a bolus injection through a peripheral vein followed by a flush and 10 minute continuous brain PET imaging will begin 50 minutes post-injection.<br>* Other names: PET tracer for Amyloid-beta;Device: Radioligand 18F-AV-1451<br>* At the Duke University PET Center you will be in a quiet dimly lit space with only ambient room sound, with your eyes open and ears unplugged. Your safety will be monitored by a physician and nurse. 18F-florbetapir will be administered to you as a bolus injection through a peripheral vein followed by a flush and 10 minute continuous brain PET imaging will begin 50 minutes post-injection.<br>* Other names: PET tracer for Tau protein;|
| Active Comparator: Trauma only<br>Volunteers that do not have PTSD but have had similar trauma to those with PTSD | Device: MRI<br>* You will be asked to undergo a scan of your brain called an MRI. The MRI scan can measure the functioning of your brain.<br>Device: PET<br>* You will be asked to undergo a scan of brain called a positron emission tomography (PET) scan. The PET scan is a test that uses radioactive glucose (sugar) and a computer to create images of how your brain is functioning. Abnormal cells in the body use glucose at a different rate than normal cells and this allows the scanner to create a detailed picture of how your body is working.<br>Device: 18F-Florbetapir<br>* At the Duke University PET Center you will be in a quiet dimly lit space with only ambient room sound, with your eyes open and ears unplugged. Your safety will be monitored by a physician and nurse. 18F-florbetapir will be administered to you as a bolus injection through a peripheral vein followed by a flush and 10 minute continuous brain PET imaging will begin 50 minutes post-injection.<br>* Other names: PET tracer for Amyloid-beta;Device: Radioligand 18F-AV-1451<br>* At the Duke University PET Center you will be in a quiet dimly lit space with only ambient room sound, with your eyes open and ears unplugged. Your safety will be monitored by a physician and nurse. 18F-florbetapir will be administered to you as a bolus injection through a peripheral vein followed by a flush and 10 minute continuous brain PET imaging will begin 50 minutes post-injection.<br>* Other names: PET tracer for Tau protein;|
| Active Comparator: PTSD only<br>Volunteers with PTSD but no traumatic brain injury | Device: MRI<br>* You will be asked to undergo a scan of your brain called an MRI. The MRI scan can measure the functioning of your brain.<br>Device: PET<br>* You will be asked to undergo a scan of brain called a positron emission tomography (PET) scan. The PET scan is a test that uses radioactive glucose (sugar) and a computer to create images of how your brain is functioning. Abnormal cells in the body use glucose at a different rate than normal cells and this allows the scanner to create a detailed picture of how your body is working.<br>Device: 18F-Florbetapir<br>* At the Duke University PET Center you will be in a quiet dimly lit space with only ambient room sound, with your eyes open and ears unplugged. Your safety will be monitored by a physician and nurse. 18F-florbetapir will be administered to you as a bolus injection through a peripheral vein followed by a flush and 10 minute continuous brain PET imaging will begin 50 minutes post-injection.<br>* Other names: PET tracer for Amyloid-beta;Device: Radioligand 18F-AV-1451<br>* At the Duke University PET Center you will be in a quiet dimly lit space with only ambient room sound, with your eyes open and ears unplugged. Your safety will be monitored by a physician and nurse. 18F-florbetapir will be administered to you as a bolus injection through a peripheral vein followed by a flush and 10 minute continuous brain PET imaging will begin 50 minutes post-injection.<br>* Other names: PET tracer for Tau protein;|
| Active Comparator: PTSD and TBI<br>Volunteers with PTSD and mild traumatic brain injury | Device: MRI<br>* You will be asked to undergo a scan of your brain called an MRI. The MRI scan can measure the functioning of your brain.<br>Device: PET<br>* You will be asked to undergo a scan of brain called a positron emission tomography (PET) scan. The PET scan is a test that uses radioactive glucose (sugar) and a computer to create images of how your brain is functioning. Abnormal cells in the body use glucose at a different rate than normal cells and this allows the scanner to create a detailed picture of how your body is working.<br>Device: 18F-Florbetapir<br>* At the Duke University PET Center you will be in a quiet dimly lit space with only ambient room sound, with your eyes open and ears unplugged. Your safety will be monitored by a physician and nurse. 18F-florbetapir will be administered to you as a bolus injection through a peripheral vein followed by a flush and 10 minute continuous brain PET imaging will begin 50 minutes post-injection.<br>* Other names: PET tracer for Amyloid-beta;Device: Radioligand 18F-AV-1451<br>* At the Duke University PET Center you will be in a quiet dimly lit space with only ambient room sound, with your eyes open and ears unplugged. Your safety will be monitored by a physician and nurse. 18F-florbetapir will be administered to you as a bolus injection through a peripheral vein followed by a flush and 10 minute continuous brain PET imaging will begin 50 minutes post-injection.<br>* Other names: PET tracer for Tau protein;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cortical thickness as measured by MRI scans |  | Baseline | 
| Beta amyloid plaques as measured by PET scans |  | Baseline | 
| Tau proteins as measured by PET scans |  | Baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Alzheimer Dementia, PTSD, MRI