Opioid System Cerebral Activity in Endurance Sportswomen - Addiction or Denutrition ? [11C]Diprenorphine PET Study

Study Overview
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Brief Summary
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Abnormal opioid system have been identified in addictive behavior and activity of the opioid system has also shown a strong link with the nutritional balance. A significant increase in endorphin levels was noticed after exercise, proportional to the duration and intensity of this activity. One brain imaging study showed an increase in opioid activity in athletes after endurance training. However , a decrease in opioid tone related to receptor desensitization in the brain has been raised in the sport and it is possible to feel like , the subject must perform physical exercise more frequently . Consequently, in order to deepen the hypothesis of addiction in high-level sport , the brain opioid activity should be assessed pre- training compared to a group of sedentary control subjects . Preliminary results of a previous study the investigators are conducting on anorexia nervosa (AN ) show abnormalities that appear to be involved in self addiction anorexia nervosa and the regulation of gonadal function. However, the relation of cause and effect between these anomalies and undernutrition remains to be determined . Given the addictive component in the endurance sport and the variability of the nutritional status of its practitioners , evaluation of brain activity in these subjects could provide additional answers.

Official Title
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Opioid System Cerebral Activity in Endurance Sportswomen - Addiction or Denutrition ? [11C]Diprenorphine PET Study

Conditions
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Sports Nutritional Sciences

Intervention / Treatment
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* Other: [11C]diprenorphine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: For High-level sportswomen : 18-35-year-old High-level sportswomen BMI>19kg/m2 Absence of eating disorders In pre-competition period Signature of written consent For controls : 18-35-year-old Sedentary normal weight women BMI>19kg/m2 Normal nutritional markers Absence of eating disorders or other psychiatric or organic diseases Exclusion Criteria: Oral contraception Heart failure Neuroleptics, antiparkinson drugs, alpha-methyl-dopa, beta blockers, inhibitors of monoamine oxidase-A or MOA-B, tricyclic antidepressants, selective serotonin reuptake inhibitor, thyme-regulators (lithium), anticonvulsant drugs, codeine, morphine, drugs containing tramadol, dopaminergic drugs

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: sportswomen<br>3 micrograms [11C]diprenorphine | Other: [11C]diprenorphine<br>* 3 micrograms [11C]diprenorphine - intravenous use - 1 time<br>* Other names: radiopharmacentical precursor solution;|
| Experimental: control subjects<br>3 micrgrams [11C]diprenorphine | Other: [11C]diprenorphine<br>* 3 micrograms [11C]diprenorphine - intravenous use - 1 time<br>* Other names: radiopharmacentical precursor solution;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| [11C]diprenorphine binding potential | Value of [11C]diprenorphin binding potential in predifined brains regions. [11C]diprenorphin BP will be evaluated by brain positron emission tomography and MRI exam | 2 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| correlation [11C]diprenorphine BP | Correlation between [11C]Diprenorphine binding potential and plasma endogenous opioid levels | 2 weeks | 
| correlation [11C]diprenorphine BP | Correlation between [11C]Diprenorphine binding potential and psychometric score evaluating addictive behavior, reward and positive reinforcement | 2 weeks | 
| correlation [11C]diprenorphine BP | Correlation between [11C]Diprenorphine binding potential and appetite regulating hormones | 2 weeks | 
| correlation [11C]diprenorphine BP | Correlation between [11C]Diprenorphine binding potential and LH response during GnRH test | 2 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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endurance sportswomen, addiction, undernutrition, [11C]diprenorphine Pet, pituitary region