Sex-unique Disparities in Survival and Resuscitation After Out-of-hospital Cardiac Arrest - a Danish Analysis

Study Overview
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Brief Summary
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The goal of this observational study is to investigate characteristics in out-of-hospital cardiac arrests (OHCA) related to sex differences. The main questions it aims to answer are: are there possible differences in help provision by bystanders, cardiopulmonary resuscitation (CPR), pre-hospital treatment by emergency medical services (EMS)? are there differences in the presence of shockable initial rhythm (SIR) and survival rates after OHCA at successive stages of treatment? Researchers will compare all emergency medical services treated resuscitations in Denmark between 2016 and 2021 to see if there are possible differences between sexes.

Detailed Description
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This analysis will be based on data from the national electronic based Danish OHCA registry. Data on OHCAs with resuscitative attempts in Denmark have been collected in the electronic based Danish Medical Service report system since 2016. The registry covers detailed data including the EMS report, executive entries, and advanced text searches of prehospital charts. All cases go through an elaborate validation process where all identified events are read through manually by an external verification team. This ensures high quality of data, collected according to the Utstein recommendations, throughout the approximately 5400 cases of OHCA in Denmark annually. During this verification process, supplementary sources of data are linked to each OHCA, among others information about survival, localization, initiation of bystander CPR and EMS personnel operation.

Official Title
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Sex-unique Disparities in Survival and Resuscitation After Out-of-hospital Cardiac Arrest - a Danish Analysis

Conditions
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Out-Of-Hospital Cardiac Arrest

Intervention / Treatment
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* Other: Investigation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: - All emergency medical services treated resuscitations in Denmark between 2016 and 2021 Exclusion Criteria: - Patients that are found dead at emergency medical service arrival, with sure death indicators such as rigor mortis or livores.
Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Investigation|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 30-days survival | Records on survival after 30 days from cardiac arrest | 30 days from OHCA | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cardiopulmonary Resuscitation (CPR) | Whether or not CPR was performed on the patient | 2016-2021 | 
| Presence of shockable initial rhythm (SIR) | Whether or not a schockable intial rhythm was recorded | 2016-2021 | 
| Return of spontaneous circulation (ROSC) at any time | Whether or not there was return of spontaneous circulation at any time | 2016-2021 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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SIR, sex differences, ohca, women, CPR