Hip Fracture Impact on Vascular Events In Noncardiac Surgery patIents: a cOhort evaluatioN (Hip VISION): Pilot Study

Study Overview
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Brief Summary
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Hip VISION (Pilot Study) is a Prospective Observational Cohort Study to evaluate the incidence of overall and cause-specific mortality among consecutive patients aged ≥ 18 years presenting with hip fracture to the Juravinski Hospital of the Hamilton Health Sciences. This pilot study will assess the feasibility of a larger prospective international cohort study. After eligibility has been confirmed and informed consent has been obtained, participants will be registered in the study. Troponin level, complete blood counts and serum creatinine level will be collected at day 1 through day 10 post admission. CAM instrument will be employed at admission and once daily post admission day 1 through day 10. FIM Instrument will be administered within 72 hours of admission to establish pre-fracture functional independence and disability. Patients will be contacted by research personnel by telephone 30 days after study registration.

Official Title
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Hip Fracture Impact on Vascular Events In Noncardiac Surgery patIents: a cOhort evaluatioN (Hip VISION): Pilot Study

Conditions
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Hip Fractures

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients aged ≥ 18 years with hip fractures (i.e. fractures involving the subcapital, femoral neck, or intertrochanteric regions), treated either operatively or non-operatively Mechanism of injury consistent with either: A fall from a standing height or; Another mechanism of injury which, in the clinical judgment of an orthopedic surgeon, would impart the same or less traumatic energy as a fall from a standing height Exclusion Criteria: Patients with fractures isolated to the proximal femoral shaft, with no involvement of the intertrochanteric, femoral neck, or subcapital region Patients with hip fractures resulting from high energy mechanisms, such as motor vehicle accidents or falls from a substantial height Patient who refuse 30-day or 6-month follow up Patients who refuse to consent either by themselves or through a substitute decision-maker (for patients unable to consent, we will use a deferred consent process, as described below).

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with a hip fracture<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Total and cause specific mortality in hip fracture patients at 30 days |  | 30 days | 
| Major complications within 30 days. | Composite of vascular mortality, nonfatal MI, nonfatal stroke, nonfatal PE, sepsis, and life-threatening bleeding. | 30 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Nonfatal myocardial infarction |  | 30 days | 
| Nonfatal myocardial injury after noncardiac surgery |  | 30 days | 
| Nonfatal pulmonary embolism |  | 30 days | 
| Nonfatal infection |  | 30 days | 
| Nonfatal bleeding |  | 30 days | 
| Nonfatal stroke |  | 30 days | 
| New congestive heart failure |  | 30 days | 
| New atrial fibrillation |  | 30 days | 
| Nonfatal cardiac arrest |  | 30 days | 
| Deep vein thrombosis |  | 30 days | 
| New acute renal failure requiring dialysis |  | 30 days | 
| Cardiac catheterization |  | 30 days | 
| PCI |  | 30 days | 
| CABG |  | 30 days | 
| CAM days 1-7 post-op |  | 1-7 days post-op | 
| Implant failure or periprosthetic fracture |  | 30 days | 
| Re-operation |  | 30 days | 
| Length of hospital stay |  | 30 days | 
| New nursing home residence |  | 30 days | 
| First mobilization |  | 30 days | 
| FIM (motor function) |  | 30 days |