linjc16/ctgov huggingface dataset:
Self-Assessment of Medical Abortion Outcome Using Serial Multi-level Pregnancy Tests

Study Overview
=================
Brief Summary
-----------------
This study aims to investigate the effectiveness and acceptability of the multi-level pregnancy test for self-assessment of abortion outcomes, without a routine provider contact.

Official Title
-----------------
Self-Assessment of Medical Abortion Outcome Using Serial Multi-level Pregnancy Tests

Conditions
-----------------
Medical Abortion

Intervention / Treatment
-----------------
* Behavioral: Self-assessment


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Gestational age of less than or equal to 63 days Determined by the site investigator or designee to be fully eligible for medical abortion with mifepristone followed by misoprostol according to the site's standard criteria Willing to use the MLPT at home 11-56 years old Willing and able to comply with study procedures In the judgement of the site investigator, she is capable of giving informed consent and she has signed the study informed consent or assent form Exclusion Criteria: -

Ages Eligible for Study
-----------------
Minimum Age: 11 Years
Maximum Age: 56 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Self-assessment of abortion outcome<br>Patients enrolled in the study will self-assess the outcomes of their medical abortion with the aid of a multi-level pregnancy test (MLPT) which they will perform at home. | Behavioral: Self-assessment<br>* Patients enrolled into the study will do a multi-level pregnancy test (MLPT) at enrollment, and will receive one MLPT to do at home one week after taking mifepristone and misoprostol. They will be instructed to call the study site if the at-home MLPT result do not decline, or if they experience any abortion complications.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Proportion of subjects who fail to contact the clinic when indicated within two weeks after taking the mifepristone |  | One month |
The Effect of Glyceryl Trinitate and Diamox on Cerebral Haemodynamics.

Study Overview
=================
Brief Summary
-----------------
After infusion / injection of Glyceryl trinitrate and Diamox it is wished to study the effect of drugs on the cerebral haemodynamics such as Cerebral blod flow and cerebral blod volume.

Detailed Description
-----------------
Experimental headache model open a unike opportunity to study the pathophysiological mechanisms behind headache in general and migrane in particular. Previous studies have used various techniques to study the cerebral haemodynamics as a basis for the headache pathophysiology. We wish to use a 3-Tesa MRI so study the cerebral haemodynamics after application of various pharmacological substances. The most used experimental headache model is the glyceryl trinitrate model (GTN). Where infusion of the NO donor GTN induces headache and changes in the cerebral arteries. On the other hand injection of Diamox (Acetazolamide) apparently causes increase of the cerebral blod flow with out dilation of the arteries. We wish to study the precise effect of GTN and diamox on the cerebral haemodynamics such as Cerebral blod flow (CBF) and Cerebral blod volume (CBV) via a 3-Tesla MRI.

Official Title
-----------------
The Effect of Glyceryl Trinitrate (GTN) and Diamox on Cerebral Haemodynamics Judged With the Help of 3-Tesla MRI.

Conditions
-----------------
Migraine

Intervention / Treatment
-----------------
* Drug: GTN, Diamox


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: healthy volunteers; men and women age 18-50 years. weight 50-100 kg Exclusion Criteria: Tension type headache more then once per month during the last year. Other primary headache types. Daily use of medication. Pregnant or lactating women. Headache on the trail day or 24 hours prior to the trial. Contraindications to MRI. Hypotension og hypertension. Other significant medical conditions judged by the doctor in charge.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Educational/Counseling/Training
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: GTN, Diamox|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Effect of Vitamin D on Offspring Obesity

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to observe the effect of lack or excess of Vitamin D in the first, second and third trimester on child birth weight, fat content and the secretion of metabolism related hormone, and clinical follow-up their offspring obesity.

Official Title
-----------------
Mechanism of Vitamin D in Influencing Offspring Obesity During Pregnancy

Conditions
-----------------
Pediatric Obesity

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Pregnancy women children Chinese Exclusion Criteria: -

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The level of Vitamin D of pregnancy women at second trimester |  | 20-24 weeks of pregnancy | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The level of Vitamin D of pregnancy women at first trimester |  | 12 weeks of pregnancy | 
| The level of Vitamin D of pregnancy women at third trimester |  | 28-40 weeks of pregnancy | 
| The birth weight, fat content and metabolism related hormone secretion of their offspring |  | At birth | 
| The weight, fat content and metabolism related hormone secretion of their offspring at one year old |  | One years old | 
| The weight, fat content and metabolism related hormone secretion of their offspring at 3 years old |  | 3 years old | 
| The weight, fat content and metabolism related hormone secretion of their offspring at 5-7 years old |  | 5-7 years old | 
| The weight, fat content and the secretion of metabolism related hormone of offspring at 18 years old |  | 18 years old |
Prevention and Control of Obesity in Primary School Children in Tehran

Study Overview
=================
Brief Summary
-----------------
This study evaluates the effect of an interventional model for preventing and controlling overweight and obesity in male and female fifth-graders. First, based on WHO (World Health Organization) references obese (BMI-Z score ≥ 2) and overweight (BMI-Z score ≥ 1) students from 12 primary schools (randomly allocated to 6 intervention and 6 comparison) will be screened. Then from the screened students 30 students with the following inclusion criteria will be recruited: not metabolically ill, not on a weight losing diet and not professionally athlete. For selected students BMI-Z score as primary outcome will be calculated. Demographic data, as well as data on waist and hip circumference, triceps skin-fold thickness, food intake for 3 days (2 ordinary week days and 1 weekend) and physical activity will be collected at the beginning and at end of the 6-month intervention. The approach of the study will be Health Promoting Schools. The intervention includes three components, i.e., nutrition education (students and parents), increased physical activity, and changing environment (food items offered in schools' canteens). Nutrition education will be imparted (a 30-minute session per week) by health instructors; physical activity will be done under the supervision of the school coaches (2 one-hour sessions per week). Parents' education (a 1.5-hour session) will be monthly. Finally the efficacy of the intervention will be determined and reported.

Conditions
-----------------
Childhood Obesity Prevention

Intervention / Treatment
-----------------
* Other: Education
* Other: Social support


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: BMI-Z-Score> or =1 (WHO) Students in the fifth or sixth grades Exclusion Criteria: Metabolic disorders (hypo or hyperthyroidism) Any disease which interfere with adherence to the intervention Intake of any appetite-reducing drug Doing professional sports Being on a weight reduction diet

Ages Eligible for Study
-----------------
Minimum Age: 9 Years
Maximum Age: 14 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Obese and overweight children, education<br>Overweight and obese school children in grades 5 and 6 | Other: Education<br> <br> Other: Social support<br> <br> |
| No Intervention: Obese and overweight children<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from baseline in pain on the 11-point Short Pain Scale (SPS-11) at week 24 Change from baseline BMI (Body Mass Index) at 6 months |  | Baseline, month 6 |
Readmission Risk of Patients With Heart Failure.

Study Overview
=================
Brief Summary
-----------------
Heart failure (HF) is a frequent, serious, and costly chronic disease: it leads to 150,000 hospitalizations each year in France at a cost of 525 million Euros. It is estimated that 20-40% of these hospitalizations are preventable by known interventions: home telemonitoring, care coordination, therapeutic intensification and therapeutic education. But these interventions only work if patients at high risk of rehospitalization are targeted to individualize management. In these patients, the risk of rehospitalization depends on clinical, biological, socioeconomic, care pathway, and location-related data. Existing predictive tools perform poorly due to three important limitations: non-use of unstructured clinical data, lack of integration of multimodal data, and weakness of the algorithmic approach. The objective is to design and validate a predictive algorithm for the risk of rehospitalization in heart failure patients, using multiple data sources

Official Title
-----------------
Predicting the Risk of Readmission in Patients With Chronic Heart Failure

Conditions
-----------------
Chronic Heart Failure

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: All consecutive adults Admitted to Montpellier University Hospital in 2017-2020 For heart failure Exclusion criteria: - age < 18 years

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 30 days all cause readmission rate | 30 days all cause readmission rate | day 30 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 90 days all cause readmission rate | 90 days all cause readmission rate | day 90 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Heart failure, Prediction, Personnalized medicine
5 Years of Eye Screening for ARF in Children Aged <3 Years in Flanders

Study Overview
=================
Brief Summary
-----------------
In this research we will investigate the distribution and evolution of amblyopia risk factors and other refractive errors in children younger than 3 years of age. The significance and magnitude of current global evolutions in ARF and refractive errors will be verified to update current guidelines and practices. Better insight in associated factors of amblyopia risk factors will contribute to current understanding of amblyopia.

Detailed Description
-----------------
The eye screening program of the Flemish governmental agency 'Kind en Gezin' is a well-implemented screening program for detection of ARF in children under the age of 3 years. This screening covers almost 85% of all children born in the Flemish community. Valuable information about distribution and determinants of refractive errors and ARF are collected at 'Kind en Gezin', but remain unstudied until today. Our aim is to analyze the distribution and evolution of refractive errors in children under the age of 3 years in Flanders. We suppose that identification of patterns in this distribution, and identification of determinants that influence ARF, will lead to improved knowledge about amblyopia (risk factors) and on their turn help optimize the ARF screening program. Evaluation of the distribution and evolution of refractive errors over time, and comparison with global results, will also give us insight in the significance of the myopia epidemic in Flanders.

Official Title
-----------------
Five Years of Eye Screening for Amblyopia Risk Factors in Children Aged <3 Years in Flanders: Epidemiological Retrospective Study

Conditions
-----------------
Amblyopia

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: We include all children with a PlusOptix screening between 2013 and 2018 with the age of 12±1 months or 30±1 months. Children who were screened twice, can be included twice with both screening results. Exclusion Criteria: none

Ages Eligible for Study
-----------------
Minimum Age: 13 Months
Maximum Age: 31 Months

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Refractive error per eye | Sphere, cylinder, spherical equivalent | during single-visit screening | 
| Difference in refractive error between both eyes | Sphere OD-OS, cylinder OD-OS, spherical equivalent OD-OS | during single-visit screening |
Tolerability & Safety of Premarin Vaginal Cream in Indian Postmenopausal Women

Study Overview
=================
Brief Summary
-----------------
This post-marketing study will provide local safety and tolerance data on the use of Premarin® vaginal cream.

Official Title
-----------------
A Postmarketing Surveillance Study Evaluating the Tolerability and Safety of PREMARIN VAGINAL CREAM in Indian Postmenopausal Women

Conditions
-----------------
Postmenopause

Intervention / Treatment
-----------------
* Drug: Conjugated Estrogen Cream (Premarin®)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients in whom Premarin vaginal cream is indicated. In the opinion of the investigator, sufficient intelligence and motivation for the patient to continue throughout the study. Provide signed informed consent. Exclusion Criteria: Patients not willing to give informed consent.

Ages Eligible for Study
-----------------
Minimum Age: 40 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Conjugated Estrogen Cream (Premarin®)|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Psychological Symptom Change in Veterans After Six Sessions of EFT (Emotional Freedom Techniques)

Study Overview
=================
Brief Summary
-----------------
EFT (Emotional Freedom Techniques) has been shown to significantly reduce post-traumatic stress disorder (PTSD) and other psychological symptoms such as anxiety and depression in a variety of clinical trials. This study examines the effect of a six session EFT protocol on the symptoms of veterans with clinical scores on the PTSD Checklist-Military (PCL-M). Subjects in the experimental group receive EFT coaching supplemental to, and supportive of, the usual care treatment provided by their primary care provider. Subjects in the wait list control group receive usual care for a month, with pre and posttests, after which they also receive the EFT coaching protocol. Subjects are followed at three month intervals to determine if gains are maintained, and whether the symptom reductions are similar to those observed in other trials of EFT.

Official Title
-----------------
Psychological Symptom Change in Veterans After Six Sessions of EFT (Emotional Freedom Techniques): A Randomized Controlled Trial

Conditions
-----------------
Stress Disorders, Post-Traumatic

Intervention / Treatment
-----------------
* Behavioral: EFT (Emotional Freedom Techniques)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Military Service The ability to follow instructions, complete written forms, and provide informed consent. Remaining under the care of a primary care provider such as a VA hospital throughout the entire period of the study Between 18 and 90 years old Exclusion Criteria: Participants with a score of more than 3 on questions 34 and 35 of the Symptom Assessment-45 Questionnaire (SA-45) will receive phone/skype sessions, not office visits

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: EFT<br>Six sessions of EFT (Emotional Freedom Techniques) | Behavioral: EFT (Emotional Freedom Techniques)<br>* Six sessions of EFT<br>|
| No Intervention: Wait List<br>One month wait period | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| PTSD Scores on the PCL-M Assessment |  | One Month Before, At Start, After 3 and 6 Sessions, After 3 and 6 Months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
veterans,, PTSD,, EFT (Emotional Freedom Techniques),, depression,, anxiety
Forensic Dental Age Estimation : Validation of Computed Tomography for Third Molar Demirjian's Staging

Study Overview
=================
Brief Summary
-----------------
Age can be estimated in different ways by using skeletal age and dental age. Currently, bone age is determine thanks to the wrist x-rayed, and the dental age using variation in mineralization (Demirjian's score) on the dental panoramic (Mincer 1993). More recently, reviews indicate the Computed tomography (CT) scan of the medial clavicular epiphysics can contribute to improve the accuracy of individual's age estimation (Houpert, 2016). Furthermore, with the recent advances, the very low dose CT scan acquisitions can be perform with sufficient quality for the teeth analysis. The goal of this study is to validate the use of dental CT for Demirjdian's staging method.

Official Title
-----------------
Forensic Dental Age Estimation : Validation of Computed Tomography for Third Mandibular Molar Demirjian's Staging Method in a 0- 25 Years French Living Population

Conditions
-----------------
Mandible Fracture

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: Patient aged between 0 and 25 years old Complete dental panoramic CT scan including mandible and maxilla Maximum of 2 months between CT scan and dental panoramic Medical imaging available on the PACS Exclusion criteria: Medical imaging missing on the PACS Patient refuses to participate

Ages Eligible for Study
-----------------
Minimum Age: 0 Years
Maximum Age: 25 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| weighted Kappa test between CT scan | weighted Kappa test between CT scan and dental panoramic assessment of Demirjian's staging of third mandibular molar | day 1 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mineralization difference | Mineralization difference between mandibular and maxillar third molar | day 1 | 
| Dental age estimation in a south french population | Dental age estimation in a south french population | day 1 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Validation CT scan, Radiography, Dental age estimation, CT scan, dental panoramic