RNFL Thickness Measurements Obtained Using SD-OCT and SLP Using GDx Variable Corneal Compensation

Study Overview
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Brief Summary
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The aim of this study is to evaluate the correlation of retinal nerve fiber layer (RNFL) thickness measured using spectral domain optical coherence tomography (SD-OCT) and scanning laser polarimetry (SLP) in uveitic eyes compared to healthy eyes. A descriptive, observational, prospective, consecutive, cross-sectional, controlled, mono-center case series was conducted from May to October 2015. Clinical characteristics, best-corrected visual acuity, intra-ocular pressure, RNFL thickness measurement with SD-OCT and SLP using GDx variable corneal compensation (GDx VCC) were performed for each patient. An evaluation of anterior chamber inflammation with laser flare cell meter was also carried out. Correlations between SD-OCT and GDx VCC RNFL measurement were evaluated by linear regression analysis.

Official Title
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Correlation in Retinal Nerve Fiber Layer Thickness in Uveitis and Healthy Eyes Using Scanning Laser Polarimetry and Optical Coherence Tomography

Conditions
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Uveitis

Intervention / Treatment
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* Device: SD-OCT and SLP using GDx variable corneal compensation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age ≥18 years, best-corrected visual acuity better than or equal to 20/40, spherical refraction between -6.00 and +3.00 diopters, no retinal disease or non-glaucomatous neuropathy, and no ophthalmic surgery in the past 6 months. Exclusion Criteria: Healthy eye were excluded in case of consecutive and reliable abnormal standard automated perimetry with abnormal Glaucoma Hemifield Test and pattern standard deviation outside 95% of normal limits, and optic nerve damage (asymmetric cup-to-disc ratio ≥ 0.2, rim thinning, notching, excavation, or retinal nerve fiber layer defect). any history of ophthalmic disease.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| healthy eyes<br> | Device: SD-OCT and SLP using GDx variable corneal compensation<br>* RNFL thickness measurements obtained using SD-OCT and SLP using GDx variable corneal compensation<br>|
| uveitis eyes<br> | Device: SD-OCT and SLP using GDx variable corneal compensation<br>* RNFL thickness measurements obtained using SD-OCT and SLP using GDx variable corneal compensation<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Retinal nerve fiber thickness (RNFL) | measures are made with spectral domain optical coherence tomography (SD-OCT) in micrometer | at inclusion | 
| Retinal nerve fiber thickness (RNFL) | measures are made with scanning laser polarimetry (SLP) in micrometer | at inclusion | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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retinal nerve fiber layer thickness, uveitis, SD-OCT, GDx VCC