Effectiveness of Permethrin Impregnated Underwear in Preventing Louse Proliferation in Infected Homeless

Study Overview
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Brief Summary
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Homelessness, also name the fourth world, is a growing public health problem worldwide. Previous studies showed that up to 30% of the homeless people reported pruritus that often results in itchy lesions, which expose them to bacterial skin infections. The investigators therefore conducted a randomized, double-blind, placebo-controlled trial to test the hypothesis that a single oral dose of ivermectin was effective in significantly reducing the prevalence of pruritus in a sheltered homeless population.

Official Title
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Effectiveness of Permethrin Impregnated Underwear in Preventing Louse Proliferation in Infected Homeless

Conditions
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Body's Louses

Intervention / Treatment
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* Drug: Permethrin impregnated
* Drug: no Permethrin impregnated


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient HOMELESS PERSON  individual who has no regular access to a conventional residence , appearing during the period of study at reception centers (Forbin or Madrague Ville) and being in the habit of wearing there (at least 4 times a week), Male genital organ and feminine, Of more than 18 years old, Presenting of the prurit, hurts of scratching or the louses Wishing to change his underwear, Having given his lit(enlightened) consent Exclusion Criteria: Woman presenting a sexually transmitted infection (infection with gonococcus, with Chlamydia trachomatis, with Trichomonas vaginalis) revealing on the takings realized during the consultation of inclusion but the bacteriological results of which will be known only secondarily. Pregnant Woman presenting to the consultation of inclusion of métrorragies either a break of the pocket of waters or an infectious complication of the pregnancy. Woman removing her consent during the study. Lost sight Woman. Woman deprived of freedom, judicial or administrative; Woman hospitalized for quite other reason that looks for her(it); Woman hospitalized in a sanitary establishment or social in the other purposes that the research; Major Woman except state to express its consent

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: no permethrin<br> | Drug: no Permethrin impregnated<br> <br> |
| Experimental: permethrin<br> | Drug: Permethrin impregnated<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Show that underwear soaked with permethrine in 8 % allow to reduce in a long-lasting way (J90 and J365) of 50 % the index of infestation and prevalency of the louses in the group treated with regard to the group placebo. |  | 2 YEARS | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Show that underwear soaked with permethrine in 8 % allow to reduce in a long-lasting way (J90 and J365) of 50 % the index of infestation and prevalency of the louses in the group treated with regard to the group placebo. |  | 2 years |