Obstetric Outcomes After Double Embryo Transfer

Study Overview
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Brief Summary
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Aim ; to compare live birth after single embryo transfer versus double embryo transfer

Detailed Description
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Assisted reproductive technology with intracytoplasmic sperm injection (ICSI) and IVF is becoming an international direction for couples struggling with infertility. The increasing popularity and frequency of these techniques and the data generated from it has given us a better overview of the efficacy, consequences and costs of these techniques. The aim of assisted reproductive technology (ART) is to achieve pregnancy while decreasing the risk of multiple gestations. When compared with elective single embryo transfer (SET), double embryo transfer (DET) demonstrates a superior pregnancy and live birth rate with a significantly higher risk of multiple gestations. The high frequency of multiple births is the main factor which leads to adverse outcome in IVF/intracytoplasmic sperm injection (ICSI) treatment. Transfer of two embryos does not diminish the chance of a birth when compared with three embryo transfer. How would be the obstetric outcome in pregnancies resulting from DET in IVF/ICSI cycles. Despite achieving a higher pregnancy rates, DET in ART leads to an increase in multiple gestation pregnancies, which are associated with increased both maternal and neonatal morbidity and mortality. Twin pregnancies have a higher incidence of preterm cesarean sections , admissions to the neonatal intensive care unit (NICU), and other maternal complications, when compared with singleton pregnancies. Twin pregnancies have a higher incidence of preterm cesarean sections , admissions to the neonatal intensive care unit (NICU), and other maternal complications, when compared with singleton pregnancies. Most patients prefer to have two embryos transferred, due to financial considerations being the main reason. Studies demonstrate that patients are more likely prefer to choose SET when educated about the risks of multiple gestation pregnancy, but select two embryos for transfer if they have a lower pregnancy rate when compared with transferring one embryo . Cost effectiveness research comparing single versus DET after in vitro fertilization (IVF) has previously been performed, with most studies taking place in areas with mandated IVF insurance coverage, and few incorporating hospital costs linked to obstetrical and neonatal outcomes.

Official Title
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Obstetric Outcomes After Double Embryo Transfer in Intracytoplasmic Sperm Injection

Conditions
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Double-Embryo Transfer in ICSI

Intervention / Treatment
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* Other: Data collection


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: all patients subjected with ICSI pregnancy after consented Exclusion Criteria: patients refuse consent Poor responders
Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Double-Embryo transfer in ICSI<br> | Other: Data collection<br>* No interventions<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To compare live births after double embryo transfer and single embryo transfer in assisted reproductive technology | Comparison | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Compare clinical evidence after single embryo transfer versus double embryo transfer Neonatal morbidities and mortalities and rate of Rate of admission to NICU in SET vs DET | Comparison | 1 year | 
| Rate of miscarriage in single embryo transfer versus double embryo transfer | Comparison | 1 year | 
| Obstetric complications in single embryo transfer versus double embryo transfer | Comparison | 1 year | 
| Rate of preeclampsia , DM and preterm labour in single embryo transfer versus double embryo transfer | Comparison | 1 year | 
| Rate of neonatal morbidities and mortalities in single embryo transfer versus double embryo transfer | Comparison | 1 year | 
| Rate of admission to NICU in single embryo transfer versus double embryo transfer | Comparison | 1 year |