Program for the Introduction Into Clinical Practice of the Principles of Personalized and Preventive Medicine Based on the Isolation of Gene Polymorphism in Schizophrenia in People of the Kazakh Ethnic Group

Study Overview
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Brief Summary
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This is a GWAS study that aims to identify possible candidate genes associate to schizophrenia by exploring single nucleotide polymorphism (SNP) in a group of schizophrenia, in the Kazakh population. The investigators hypothesize that the careful phenotyping of the subject sand matching with increase the power to find SNP significantly associated with schizophrenia

Detailed Description
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A genome-wide association study (GWAS) is an approach used in genetics research to associate specific genetic variations with particular diseases. The method involves scanning the genomes from many different people and looking for genetic markers that can be used to predict the presence of a disease. Once such genetic markers are identified, they can be used to understand how genes contribute to the disease and develop better prevention and treatment strategies.

Official Title
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Preventive and Personalized Medicine (2021-2023)

Conditions
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Schizophrenia

Intervention / Treatment
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* Genetic: DNA analysis


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: persons of Kazakh nationality having this ethnicity in the 3rd generation age from 18 to 65 years old; the dispensary in a psychiatric institution at the place of residence with a diagnosis of Paranoid schizophrenia; the duration of the disease is at least 1 year (from the moment of taking under dispensary supervision): absence of severe and chronic somatic diseases; absence of severe and chronic neurological diseases; absence of comorbid drug addiction pathology; signed informed consent to conduct this study Exclusion Criteria: persons of non-Kazakh nationality and Kazakh nationality, not confirmed until the 3rd generation age less than 18 years old and over 65 years old; those who are on dispensary registration in a psychiatric institution at the place of residence with a diagnosis not related to ICD-10 under the heading F20.0 Paranoid schizophrenia; having a disease duration of less than 1 year (from the moment of taking under dispensary supervision): having severe and chronic somatic diseases; having severe and chronic neurological diseases; having comorbid narcological pathology; not signed informed consent to conduct this study

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental group:<br>Patients with schizophrenia | Genetic: DNA analysis<br>* GWAS<br>|
| Control group<br>Patients without schizophrenia | Genetic: DNA analysis<br>* GWAS<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| number of SNPs associated with schizophrenia | Using GWAS to identify candidate genes associate with schizophrenia | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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GWAS