Neuroimaging Studies of Chronic Primary Headaches Using Positron Emission Tomography and Magnetic Resonance Imaging

Study Overview
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Brief Summary
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Investigators hypothesize that chronic primary headaches are accompanied by a discrete pattern of brain metabolism and activity involving brain structures related to the development of acute exacerbations as well as pain modulation. Such structures include the brainstem, hypothalamus, and orbitofrontal cortex and can be defined using functional brain imaging.

Detailed Description
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Specific aims of the study include: To determine the pattern of brain metabolism using positron emission tomography (PET) found in chronic migraine, episodic migraine and control patients. To determine changes of resting state brain networks using magnetic resonance imaging (MRI) between patients with chronic or episodic headache and healthy volunteers.

Official Title
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Neuroimaging Studies of Chronic Primary Headaches Using Positron Emission Tomography and Magnetic Resonance Imaging

Conditions
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Migraine, Chronic Migraine

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients aged 18-65 No medical contraindication. Chronic headache group: Patients with chronic primary headaches who are experiencing phases with background pain as well as habitual pain exacerbations. Able to provide informed consent. Not pregnant or planning to become so, with a pregnancy test prior to scanning. Control group and Episodic migraine group: Patients with episodic migraine Able to provide informed consent. Not pregnant or planning to become so, with a pregnancy test prior to scanning. Exclusion Criteria: Taking a migraine preventive currently or in the last fifteen days. Known claustrophobia Patient is pregnant, planning to be pregnant, or becomes pregnant. Patients with metal implants. Patients who have had a study involving radiation within the one year prior to enrolling in this study

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Control<br>Headache-free subjects. | |
| Episodic migraine<br>Patients with less that 15 headache days per month that fulfill International Classification of Headache Disorders 2R (ICHD-2nd edition Revised)- criteria for Episodic Migraine. | |
| Chronic migraine<br>Patients that fulfill International Classification of Headache Disorders (ICHD)-2R criteria for chronic migraine (more than 15 days per month). | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pattern of brain metabolism using positron emission tomography(PET). | Neuroimaging Studies of Chronic Primary Headaches Using Positron Emission Tomography and Magnetic Resonance Imaging to determine the pattern of brain metabolism. | Estimated to be approximately three years post baseline | 
| Changes of resting state brain networks using magnetic resonance imaging (MRI) | Neuroimaging Studies of Chronic Primary Headaches Using Positron Emission Tomography and Magnetic Resonance Imaging (MRI) To determine any changes of resting state brain networks | Estimated to be approximately three years post baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Episodic migraine, Chronic migraine, Magnetic resonance imaging, Positron emission tomography