Serum Free Fatty Acid Metabolite Biomarkers of Lung Cancer

Study Overview
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Brief Summary
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This study aims to evaluate the performance of serum free fatty acids as biomarkers for the identification of lung cancer.

Detailed Description
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We will compare the concentration of free fatty acids and their metabolites between patients with lung cancer and control pulmonary patients without known cancer. The diagnostic accuracy will be assessed for potential predictors.

Official Title
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Serum Free Fatty Acid Metabolite Biomarkers of Lung Cancer

Conditions
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Lung Cancer, Biomarkers, Fatty Acids

Intervention / Treatment
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* Other: serum sample


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age from 40 to 80 Lung adenocarcinoma with pathological diagnosis Lung squamous cell carcinoma with pathological diagnosis Control patients should have at least one of the following criteria: (1) current or ex-smoker with at least a 10 pack-year history, (2) a first-degree relative with a history of lung cancer, or (3) a clinical diagnosis of COPD. Exclusion Criteria: - Lung cancer patient without serum sample before the initiation of treatment

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Lung adenocarcinoma patients<br>Serum samples were collected from patients with lung cancer at the time of their diagnosis, prior to the initiation of treatment. Diagnosis of lung adenocarcinoma was based on pathologic analysis. | Other: serum sample<br>* Serum samples from lung cancer patients were collected at the time of their diagnosis, prior to the initiation of treatment. Serum samples of control subjects were collected from a biobank<br>|
| Control matched to adenocarcinoma<br>Control subjects without known cancer and aged from 40 to 75 years should meet at least one of the following criteria: (1) current or ex-smoker with at least a 10 pack-year history, (2) a first-degree relative with a history of lung cancer, or (3) a clinical diagnosis of COPD. | Other: serum sample<br>* Serum samples from lung cancer patients were collected at the time of their diagnosis, prior to the initiation of treatment. Serum samples of control subjects were collected from a biobank<br>|
| Lung squamous cell carcinoma patients<br>Serum samples were collected from patients with lung cancer at the time of their diagnosis, prior to the initiation of treatment. Diagnosis of lung squamous cell carcinoma was based on pathologic analysis. | Other: serum sample<br>* Serum samples from lung cancer patients were collected at the time of their diagnosis, prior to the initiation of treatment. Serum samples of control subjects were collected from a biobank<br>|
| Control matched to squamous cell<br>Control subjects without known cancer and aged from 40 to 75 years should meet at least one of the following criteria: (1) current or ex-smoker with at least a 10 pack-year history, (2) a first-degree relative with a history of lung cancer, or (3) a clinical diagnosis of COPD. | Other: serum sample<br>* Serum samples from lung cancer patients were collected at the time of their diagnosis, prior to the initiation of treatment. Serum samples of control subjects were collected from a biobank<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Compare Concentration of Fatty Acids and Their Metabolites | Biochemical analysis of serum sample was conducted by an investigator who was strictly blinded to cancer status and patient characteristics. | At the time of diagnosis, prior to the initiation of lung cancer treatment |