Nanocrystalline Hydroxyapatite Bone Substitute for Treating Periodontal Intrabony Defects

Study Overview
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Brief Summary
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The present clinical trial included 20 patients (11 females and 9 males, aged 36 to 56 years) suffering from moderate or advanced chronic periodontitis. Subjects were recruited from the outpatient clinic, Department of Oral Medicine and Periodontology, Faculty of Dentistry, Cairo University. This clinical trial was meant to assess clinically and radiographically the possible predictable results regarding the use of nanocrystalline hydroxyapatite bone graft substitute together with open flap debridement versus open flap debridement alone in the treatment of periodontal intrabony defects.

Detailed Description
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periodontal intrabony defects in patients with moderate or advanced chronic periodontitis were treated with open flap debridement only in the control group while open flap debridement and Nanocrystalline Hydroxyapatite bone graft substitute was performed for the intervention group. probing pocket depth, clinical attachment level, gingival index, plaque index, gingival recession and bone defect area were assessed at baseline and six months post surgically to evaluate the possible improvement in the clinical and radiographic outcomes.

Official Title
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Clinical and Radiographic Evaluation of Open Flap Debridement With or Without Nanocrystalline Hydroxyapatite Bone Graft in Management of Periodontal Intrabony Defects

Conditions
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Chronic Periodontitis

Intervention / Treatment
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* Procedure: open flap debridement
* Procedure: n-HA bone graft


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: systemically healthy patients diagnosed with moderate to advanced chronic periodontitis periodontal defects with at least one site with probing pocket depth (PPD) ≥ 5mm, clinical attachment loss (CAL) ≥ 4mm and two or three-walled intra-bony defects ≥ 3mm evidence of intrabony defects using periapical radiographs Exclusion Criteria: teeth with suprabony defects or 1-wall intrabony defects pregnant or lactating women patients taking any medication 3 months prior to the study patients receiving any periodontal treatment 6 months prior to study initiation former or current smokers.

Ages Eligible for Study
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Minimum Age: 35 Years
Maximum Age: 56 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: OFD control group<br>open flap debridement for periodontal intrabony defects | Procedure: open flap debridement<br>* open flap debridement for managing two and three walls intrabony periodontal defects<br>|
| Experimental: n-HA bone graft intervention group<br>Nanocrystalline Hydroxyapatite (n-HA) bone graft substitute was added to periodontal intrabony defects | Procedure: open flap debridement<br>* open flap debridement for managing two and three walls intrabony periodontal defects<br>Procedure: n-HA bone graft<br>* Nanocrystalline Hydroxyapatite bone graft substitute for managing two and three walls intrabony periodontal defects<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change in probing pocket depth | William's graduated periodontal probe used to measure probing pocket depth from the gingival margin to the base of the sulcus | baseline and after six months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change in clinical attachment level | William's graduated periodontal probe used to measure clinical attachment level from the cementoenamel junction to the base of the sulcus | baseline and after six months | 
| change in the bone defect area | periodical digital radiographs using Digora software to measure the bone defect area | baseline and after six months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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periodontal intrabony defects