Efficacy Study of Clinical Nutrition to Treat Lung Neoplasms And Breast Carcinoma

Study Overview
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Brief Summary
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This study evaluates the efficacy of clinical nutrition to treat lung neoplasms and breast carcinoma.We estimate there will be 480 patients accepted.120 patients will receive GLSE compound,120 patients will recrive Maitake mushroom extract compound,120 patients will recrive Rinseng compound,and 120 patients will be as blank countrol group.Efficacy Study of Clinical Nutrition to Treat Lung Neoplasms And Breast Carcinoma

Detailed Description
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GLSE compound、Maitake mushroom extract compound and Rinseng compound have different mechanism on enhancing immunity.This clinicaltrial compare them the immune effect in the progress of treating lung neoplasms and breast carcinoma.Within the 42 days,we will abide by the plan to evaluate the immunity enhancement by monitoring mmune effector molecules.

Official Title
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Phase 1 Study of Clinical Nutrition That Research Safty and Efficacy in Lung Neoplasms And Breast Carcinoma

Conditions
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Lung Neoplasms, Breast Neoplasms

Intervention / Treatment
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* Drug: GLSE compound
* Drug: Maitake mushroom extract compound
* Drug: Ginseng compound


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: lung cancer and breast cancer patients confirmed by surgery pathology; ECOG physical stamina score of 0 3 points; Expected lifetime > 3 months; Need to receive radiation and chemotherapy; Heart, liver and kidney function and blood picture is normal,WBC≥4×109/L, neutrophil count≥ 2 x 109 / L,platelet count≥100×109/L, hemoglobin≥100 g/L; To follow-up, good adherence Exclusion Criteria: Allergic to text drug; Pregnancy or lactation women; Suffering from mental illness of not easy to control, Have serious mental or cognitive dysfunction; Can not comply with the experimental scheme or can't cooperate with the follow-up; The patients who are unfavorable to the subject.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: GLSE compound group<br>GLSE compound 2g each time by mouth,twice a day for 42 days. | Drug: GLSE compound<br> <br> |
| Experimental: Maitake mushroom extract compound group<br>Maitake mushroom extract compound 2 tables each time by mouth,twice a day for 42 days. | Drug: Maitake mushroom extract compound<br> <br> |
| Experimental: Ginseng compound group<br>Ginseng compound 2 tables each time by mouth,twice a day for 42 days. | Drug: Ginseng compound<br> <br> |
| No Intervention: blank control group<br>Take nothing. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| T-lymphocyte cell subsets | T-lymphocyte cell subsets contains CD3+、CD4+、CD8+、CD28-、CD28+、CD4+CD25+、HLADR+、HLADR-,measured these cells concentration level | three mouths | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Clinical Nutrition