Influence of PBM on Anaerobic Capacity Under Normoxia and Hypoxia

Study Overview
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Brief Summary
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The photobiomodulation (PBM) shows positive results in muscle performance, fatigue reduction, management of blood lactate production, analgesia and in the increase of VO2 maximal, favoring the increase of ATP production and thus the energy metabolism. The association of PBM applied before high-intensity treadmill training shows physiological improvements both in normoxic (Nor) and hypoxic (Hip) conditions. Anaerobic capacity (AC) is the maximum amount of ATP that can be resynthesized by anaerobic metabolism and is an important predictor of high-intensity exercise since an athlete's ability to perform efforts to increase maximal oxygen consumption (VO2max) depends on AL. In view of the above information the main objective of the present research project will be to investigate the effects of PBM on AC under normoxic and hypoxic conditions in amateur runners. To test the effects of exercise training on anaerobic capacity under normoxic and hypoxic conditions, 7 individuals will be randomly submitted to four maximal efforts to exhaustion with intensity corresponding to 110% of VO2max in Hip, Nor, Hip+Ebio and Nor+Ebio conditions. These efforts will be used to estimate the AC, that is, the maximum accumulated deficit of alternative oxygen (MAODRED), from the sum of the energy contribution of the anaerobic and lactic metabolisms.

Official Title
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Influence of Photobiomodulation on Anaerobic Capacity Under Normoxia and Hypoxia Conditions in Treadmill Runners

Conditions
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Low Level Laser Therapy, Photobiomodulation, Performance, Sport

Intervention / Treatment
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* Device: Photobiomodulation therapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: healthy individuals VO2 maximal equal to or greater than 34 ml/kg.min capacity for physical activity according to the PAR-Q questionnaire Exclusion Criteria: musculoskeletal injury in the last three months; cardiovascular diseases; use of anabolic, anti-inflammatory and analgesic drugs 72 hours before the evaluations; use of alcohol and illicit drugs during the collection period;

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 29 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Hypoxia<br>Participant developed running activity on a treadmill in hypoxic condition, submitted or not to photobiomodulation therapy. | Device: Photobiomodulation therapy<br>* A previous application of photobiomodulation therapy was offered or not, for possible performance enhancement.<br>|
| Active Comparator: Normoxia<br>Participant developed treadmill running activity in normoxic condition, submitted or not to photobiomodulation therapy. | Device: Photobiomodulation therapy<br>* A previous application of photobiomodulation therapy was offered or not, for possible performance enhancement.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Analysis of excess oxygen consumption observed after exercise and blood lactate | To investigate the effects of photobiomodulation on anaerobic capacity in normoxia and hypoxia conditions in amateur runners | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Analysis of V02 max by a single supramaximal effort performed to exhaustion | To determine the alactic and lactic anaerobic and lactic anaerobic participation during exhaustive effort performed at 120% of VO2max in normoxia, hypoxia and with intervention of photobiomodulation | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Physical Therapy, Photobiomodulation, Athletic Performance, Hypoxia