Investigation of Neurophysiological Markers, Possibly Specific of Two Subforms of Psychotic Disorders

Study Overview
=================
Brief Summary
-----------------
The current diagnostic criteria for schizophrenia and other psychotic disorders are relatively broad and lack precision. Therefore, distinct diseases may be grouped together under the same diagnostic category, although these diseases may differ according to their clinical expression, prognosis and perhaps their physiopathological causes. We think that identifying subforms of psychotic disorders that are more homogeneous will better enable to understand their respective physiopathological causes and find personalized treatments. This study will compare two subforms of psychotic disorders that have been clinically distinguished in the 1970s. These phenotypes have however not been validated yet using scientific investigations. Using clinical assessments, cognitive evaluations and neurophysiological measures (fMRI) investigating the domains of affect and psychomotoricity , we expect that these two subforms will differ on their clinical, cognitive and neurophysiological characteristics, namely: hebephrenia will be associated with deficits on the affect markers , and respect psychomotoricity (catatonia scales, tests assessing movement planification) whereas the opposite pattern will be observed for periodic catatonia.

Official Title
-----------------
Investigation of Clinical, Cognitive and Neurophysiological Markers, Possibly Specific of Two Subforms of Psychotic Disorders

Conditions
-----------------
Schizophrenia

Intervention / Treatment
-----------------
* Other: compare the two groups of schizophrenic patients
* Other: compare the two groups of schizophrenic patients versus volunteers


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: for both patients and controls male or female willing to participate and who have signed up the legal document under the protection of health insurance for patients only schizophrenia or schizo-affective disorder according to the DSM-5 criteria periodic catatonia or hebephrenia accordin to WKL classification clinically stable for at least 2 months in or out patients for controls only no psychiatric history Exclusion Criteria: for both patients and controls current severe or unstable somatic illness neurological history (epilepsia, brain injury, brain surgery…) current substance use disorder (DSM-5) current major depressive disorder (DSM-5) mental retardation (IQ < 70) pregnancy, breast feeding current legal control contra-indication for fMRI for controls only psychotropic intake during the last 3 weeks

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: patient with schizophrenia and periodic catatonia<br> | Other: compare the two groups of schizophrenic patients<br>* Compare two groups of markers relating respectively to psychomotricity and affectivity in two subforms of schizophrenia: periodic catatonia and hebephrenia in order to highlight a possible double dissociation: abnormalities of markers related to affectivity in Hebephrenia (with preservation of these markers in periodic catatonia), abnormalities of markers related to psychomotricity in periodic catatonia (with markers of these tests in Hebephrenia).<br>Other: compare the two groups of schizophrenic patients versus volunteers<br>* compare the results of the schizophrenic patient group with healthy volunteers<br>|
| Experimental: patient with schizophrenia and hebephrenia<br> | Other: compare the two groups of schizophrenic patients<br>* Compare two groups of markers relating respectively to psychomotricity and affectivity in two subforms of schizophrenia: periodic catatonia and hebephrenia in order to highlight a possible double dissociation: abnormalities of markers related to affectivity in Hebephrenia (with preservation of these markers in periodic catatonia), abnormalities of markers related to psychomotricity in periodic catatonia (with markers of these tests in Hebephrenia).<br>Other: compare the two groups of schizophrenic patients versus volunteers<br>* compare the results of the schizophrenic patient group with healthy volunteers<br>|
| Active Comparator: healthy volunteers<br> | Other: compare the two groups of schizophrenic patients<br>* Compare two groups of markers relating respectively to psychomotricity and affectivity in two subforms of schizophrenia: periodic catatonia and hebephrenia in order to highlight a possible double dissociation: abnormalities of markers related to affectivity in Hebephrenia (with preservation of these markers in periodic catatonia), abnormalities of markers related to psychomotricity in periodic catatonia (with markers of these tests in Hebephrenia).<br>Other: compare the two groups of schizophrenic patients versus volunteers<br>* compare the results of the schizophrenic patient group with healthy volunteers<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Index of affect | Compare two groups of markers relating respectively to affectivity in two subforms of schizophrenia: periodic catatonia and hebephrenia in order to highlight a possible double dissociation | 6 months after inclusion | 
| Index of psychomotoricity | Compare two groups of markers relating to psychomotricity in two subforms of schizophrenia: periodic catatonia and hebephrenia in order to highlight a possible double dissociation | 6 months after inclusion |