Dental Care and Initiation of Anti-osteoporotic Therapy

Study Overview
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Brief Summary
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The initiation of bisphosphonate therapy for osteoporosis requires an assessment of the oral status to prevent the risk of osteonecrosis of the jaw. This recommendation is sometimes a hindrance to the initiation of treatment or may be responsible for a delay in treatment or even the failure to initiate treatment. However, in the case of a severe osteoporotic fracture (femoral or humeral neck fracture, vertebral fracture or pelvic fracture), treatment must be rapid because of the major risk of refracture in the short term (multiplied by 5 in the 2 years following the fracture). In the rheumatology department of the Nice University Hospital, the investigator team take care of patients with osteoporotic fractures either directly in hospital or referred by the orthopedics department as part of a care program. For these patients, the team perform an etiological assessment, bone densitometry and evaluation of the oral status with dental panoramic and tele-expertise to determine if there is an indication to perform surgical care before starting the treatment. Therefore, the investigator aimed to describe the number of patients requiring dental surgery befor the initiation of bisphosphonate or denosumab treatment before to introduce treatment for osteoporosis

Official Title
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Dental Care and Initiation of Anti-osteoporotic Therapy

Conditions
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Dental Condition, Osteoporosis

Intervention / Treatment
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* Drug: biphosphonates
* Procedure: Dental care


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: osteoporotic fracture requiring treatment with bisphosphonate or denosumab Exclusion Criteria: osteoporotic fracture requiring teriparatide treatment

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Treatment initiation<br>patients with a satisfactory oral assessment authorizing the immediate prescription of treatment. | Drug: biphosphonates<br>* Initiation of bisphosphonate therapy<br>|
| Surgical dental care<br>patients requiring surgical dental care before treatment initaition. | Procedure: Dental care<br>* Surgical dental care<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patients requiring surgical dental care | describe the number of patients requiring surgical dental care before to start osteoporosis treatment vs the number of patients with a satisfactory oral assessment authorizing the immediate prescription of treatment | 15 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Impact of dental care on osteoporosis treatment | Delay of treatment implementation (in days) | Change from baseline | 
| Impact of dental care on osteoporosis treatment | New osteoportic fracture occurence (in day since treatment start) | Change from baseline | 
| Impact of dental care on osteoporosis treatment | Dental complications apperance | Change from baseline |