The Relation Between Thyroid , Parathyroid Hormones and eGFR in CKD Patients in Assiut

Study Overview
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Brief Summary
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To evaluate the relation between thyroid, parathyroid hormones and estimated glomerular filtration rate in chronic kidney disease .

Detailed Description
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CKD is defined as abnormalities of kidney structure or function, present for >3 months, with implications for health. CKD is classified based on Cause, GFR category (G1-G5), and Albuminuria category (A1-A3) . The global prevalence of CKD is 13.4%, with 10.6% being stages 3-5 ,Over the past 10 years, the death rate due to CKD has increased by 31.7% . CKD patients remain sometimes asymptomatic, presenting the complications typical of renal dysfunction only in more advanced stages. Its treatment can be conservative usually in patients with glomerular filtration rate above 15 ml/minute without indications of dialysis or replacement therapy . In CKD patients the changes of endocrine system levels may arise from several causes as the kidney is the site of degradation & synthesis of many different hormones . So thyroid and parathyroid hormones dysfunction has been recognized as common co-morbidity that is often diagnosed with CKD . Thyroid hormone is one of the most important hormones in the human body as it regulates majority of the body's physiological actions . Parathyroid hormone (PTH) is one of the most important hormones required for the maintenance of calcium and phosphate homeostasis . Chronic kidney disease metabolic bone disorder (CKD-MBD) among patients with end stage renal disease ranges from 33% to 67%, and its severity tends to increase with the progression of the kidney damage & high mortality rates . CKD-MBD causes bone abnormalities that affect turnover, volume, mineralization, vascular, linear growth, and density, and soft tissue calcification .

Official Title
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The Relation Between Thyroid , Parathyroid Hormones and Estimated Glomerular Filtration Rate in Chronic Kidney Disease Patients in Assiut

Conditions
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Thyroid, Parathyroid Diseases, CKD

Intervention / Treatment
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* Radiation: DEXA scan


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 1. CKD patients 2. Age (18-80 years) 3. Diabetic nephropathy 4. Hypertensive nephropathy 5. Chronic pyelonephritis 6. Obstructive nephropathy 7. Polycystic kidney 8. Gout nephropathy 9. Nephrosclerosis Exclusion Criteria: 1. Patients underage of 18 and above 80 2. Patients with history of thyroidectomy and parathyroidectomy 3. Patients with history of thyroid and parathyroid disease before diagnosis of CKD 4. Malignancy

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group (A)<br>40 patients with CKD (1-3) not on renal replacement therapy. | Radiation: DEXA scan<br>* bone study<br>|
| Group (B)<br>40 persons with normal kidney function and GFR ( control ). | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The Relation between thyroid , parathyroid hormones and estimated glomerular filtration rate in chronic kidney disease patients in Assiut | To evaluate the relation between thyroid, parathyroid hormones and estimated glomerular filtration rate in chronic kidney disease different stages | Baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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CKD, Thyroid, Parathyroid Diseases