Rhythmic Auditory Stimulation Optimalization for Gait Improvement in Parkinson's Disease - BeatPark Study

Study Overview
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Brief Summary
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The beneficial effects of rhythmical auditory stimulation (RAS) on spatio-temporal gait characteristics in Parkinson's disease (PD) are attested by clinical research. Nonetheless, it is still unclear which auditory information parameters (i.e. complexity, temporal regularity or adaptability to gait) maximize the effectiveness of RAS. Objectives: To evaluate the beneficial effects of RAS on spatio-temporal gait characteristics in PD patients with gait disorders according to: RAS complexity (i.e. metronome, amplitude modulated noise, music) RAS variability (i.e fixed, random, semi-random) RAS adapted in real-time to gait Variability study: To study the impact of RAS variability (i.e fixed, random, semi-random) in 20 PD patients and 20 healthy controls on spatio-temporal gait characteristics with metronome, amplitude noise and music. Adaptability studyTo study the impact of RAS adaptability (i.e fixed, random, adapted in real-time to gait) in 20 PD patients and 20 healthy controls on spatio-temporal gait characteristics with metronome, amplitude noise and music.

Official Title
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Rhythmic Auditory Stimulation Optimalization for Gait Improvement in Parkinson's

Conditions
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Parkinson's Disease

Intervention / Treatment
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* Behavioral: Neuropsychological evaluation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 18 y.o. to be able to understand the study aims and to agree to participate to have signed the consent form to be registered to social security system to reach the diagnosis criteria of idiopathic PD (Queen Square Brain Bank) gait disorder clinically observable Exclusion Criteria: pregnant or lactating woman high probability of non-compliance curators , authorship or advisers to person of full age Specific exclusion criteria for PD patients clinical signs of parkinsonian syndrome Mini Mental State Examination < 24/30 Specific exclusion criteria for controls neurological disease gait disorder

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Patient<br>Patient with Parkinson's Disease with walking test and neuropsychological evaluation | Behavioral: Neuropsychological evaluation<br>* The subjects are submitted in one hearing stimulus while they realize a walking test<br>|
| Experimental: Contrôle<br>normal control with walking test and neuropsychological evaluation | Behavioral: Neuropsychological evaluation<br>* The subjects are submitted in one hearing stimulus while they realize a walking test<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| gait velocity | evaluation of walking speed between the different conditions | 2 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| spatio-temporal gait characteristics | evaluation of other walking parameters between the different conditions | 2 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Parkinson's disease, Rhythmic auditory stimulation, Gait