Effect of High-Intensity Interval Training Compared to Hydrochlorothiazide on Ambulatory Blood Pressure

Study Overview
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Brief Summary
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The number of persons with hypertension is increasing and with it the number of related cardiovascular events and related functional or cognitive declines. While studies have suggested that physical activity, in particular, high-intensity interval training (HIIT), could be as efficient as the commonly used antihypertensive medications, no studies have actually compared their effects in the same population. This protocol will determine if HIIT is at least as efficient as hydrochlorothiazide in order to lower 24h-ambulatory blood pressure (BP) in prehypertensive older adults.

Official Title
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Effect of High-Intensity Interval Training Compared to Hydrochlorothiazide on Ambulatory Blood Pressure, Cardiovascular Health, Cognition and Mobility in Pre-Hypertensive Older Adults.

Conditions
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Hypertension,Essential, Exercise Activity

Intervention / Treatment
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* Other: 24h-Ambulatory Blood Pressure


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age at consent ≥ 60 years; Systolic Blood pressure measured through BPtru™ between SBP ≥ 120 mmHg and < 140 and or DBP ≥ 80 mmHg Being able to sign the informed consent form Exclusion Criteria: Considered highly active according to the International Physical Activity Questionnaire Practicing more than 20 min per week of High-Intensity Interval Training Use of antihypertensive medication Contraindication for the practice of intense physical activity Functional limitations related to the exercise test and to intensive training Cardiovascular pathology Atrial fibrillation Psychiatric or neurological disorder Renal failure MMSE score < 26 Persons benefiting of enhanced protection: persons deprived of their liberty by a judicial or administrative decision, persons staying in a health or social institution, adults under legal protection and patients in emergency situations. Diabetes

Ages Eligible for Study
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Minimum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: High Intensity Interval Training (HIIT)<br>For the twelve weeks of intervention, participants will have three training sessions per week. Each session will be done on a cycle ergometer and will last approximately 40 minutes. Participants will be supervised by certified kinesiologists and their training programs will be revised every four weeks. | Other: 24h-Ambulatory Blood Pressure<br>* Effect of High Intensity Interval Training compared to Hydrochlorothiazide on ambulatory Blood Pressure.<br>* Other names: Mobility;|
| Active Comparator: HydroChloroThiazide<br>For this group, participants have to take a diuretic (12,5 mg of Hydrochlorothiazide) daily prescribed by the doctor of this study, for twelve weeks. Participants should also maintain the same lifestyle habits that they had before the study. | Other: 24h-Ambulatory Blood Pressure<br>* Effect of High Intensity Interval Training compared to Hydrochlorothiazide on ambulatory Blood Pressure.<br>* Other names: Mobility;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 24h-Ambulatory Blood Pressure | The 24-hour ambulatory measure of the blood pressure (AMBP) | At baseline and after twelve weeks of intervention | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cardiovascular evaluation | Maximum incremental cardiopulmonary exercise test (VO2MAX) | Before and after twelve weeks of intervention | 
| Cognitive functions | Cognitive functions will be measured at rest with a pen-paper battery test by a neuropsychologist. The investigators will measure change of score to the cognitive tests. | Before and after twelve weeks of intervention | 
| Flow Mediated Dilatation (FMD) | Percentage of dilatation of the brachial artery | Before and after twelve weeks of intervention |