Treatment of Panic Disorder Among Individuals Consulting Emergency Departments for Non Cardiac Chest Pain

Study Overview
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Brief Summary
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The purpose of this study is to assess the impact of three different treatment modalities on panic symptoms, quality of life and use of health services among individuals consulting an emergency department for non cardiac chest pain and having Panic Disorder.

Official Title
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Efficacy of Three Treatment Modalities for Panic Disorder Among Individuals Consulting Emergency Departments for Non Cardiac Chest Pain

Conditions
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Panic Disorder, Anxiety Disorder, Mental Disorder

Intervention / Treatment
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* Behavioral: Brief cognitive-behavioral treatment for Panic Disorder
* Behavioral: Cognitive-Behavior Therapy for Panic Disorder
* Drug: paroxetine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Aged 18 and over Mastered oral and written French Consulted an emergency department for chest pain with very low risk of coronary disease (normal ECG and blood tests) Met criteria for Panic Disorder Exclusion Criteria: Chest pain with an obvious medical origin (obvious trauma or abnormal pulmonary x-rays) Had received cognitive-behavior therapy for Panic Disorder in the last six months Cognitive impairment preventing the completion of psychological assessment Past or present psychotic episode, Bipolar Disorder, or organic mental disorder Current Abuse or Dependence Disorder If another Mental Disorder is present, its severity was equal or inferior to the severity of Panic Disorder Current medical condition preventing the participant from receiving pharmacological of cognitive-behavior treatment

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: 1<br> | Behavioral: Brief cognitive-behavioral treatment for Panic Disorder<br>* One two-hour session of cognitive-behavior therapy for panic disorder<br>|
| Active Comparator: 2<br> | Behavioral: Cognitive-Behavior Therapy for Panic Disorder<br>* Seven one-hour sessions of cognitive-behavior therapy for panic disorder<br>|
| Active Comparator: 3<br> | Drug: paroxetine<br>* 40 mg die, for 6 months<br>|
| No Intervention: 4<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Panic Disorder diagnosis |  | Pre and posttreatment, and 3, 6 and 12 months after treament | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Panic symptomatology, psychological distress, quality of life, and use of health services |  | Pre and posttreatment, and 3, 6 and 12 months after treatment | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Panic Disorder, anxiety, chest pain, emergency department, cognitive-behavioral treatment