Combined Resistance and Aerobic Exercise Training on Obesity in Adolescent Girls

Study Overview
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Brief Summary
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The purpose of the study was to observe therapeutic effects of combined resistance and aerobic exercise training (CRAE) on hyperinsulemia in obese adolescent girls. Forty obese adolescent girls (14±1 years) participated in this study. The participants were randomly separated into two groups; no-exercise group (n=20) and exercise group (n=20). The exercise group performed 12 weeks of CRAE.

Official Title
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Effectiveness of Combined Resistance and Aerobic Exercise Training on Obesity in Adolescent Girls

Conditions
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Obesity

Intervention / Treatment
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* Behavioral: Combined Exercise Training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Obese with Hyperinsulinemia Obese with Abdominal obesity Exclusion Criteria: Hypertension Pregnancy Chronic diseases Weight loss diet within the last 6 months

Ages Eligible for Study
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Minimum Age: 14 Years
Maximum Age: 16 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: No Exercise (CON)<br>Twenty obese adolescent girls. This arm did not perform any exercise training for 12 weeks. Caloric intake: 1921.7 kcal/day | |
| Experimental: Exercise (EX)<br>Twenty obese adolescent girls. This arm performed combined exercise training 5 times a week for 12 weeks. Caloric intake: 1921.7 kcal/day | Behavioral: Combined Exercise Training<br>* The combined exercise training were consisted with 5 minutes of warm-up, 20 minutes of resistant band exercises (Upper: seated rows, biceps curl, shoulder flexion, elbow flexion, pushup; Lower: hip flexion, hip extension, calf raise, leg press, squat), 30 minutes of treadmill walking, and 5 minutes of cool-down. Intensity of the training was gradually increased from 40-50% heart rate reserve in 1-4 weeks to 60-70% HRR in 9-12 weeks.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Height in Meters | Height was measured before and after 12 weeks. | 12 weeks | 
| Weight in Kilograms | Weight was measured before and after 12 weeks. | 12 weeks | 
| BMI in Weight (Kilograms)/Height (Meters)^2 | BMI was calculated with weight and height before and after 12 weeks. | 12 weeks | 
| Body Fat in Percents | Body fat was measured before and after 12 weeks. | 12 weeks | 
| Lean Body Mass in Percents | Lean body mass was measured before and after 12 weeks. | 12 weeks | 
| Waist Circumference in Centimeters | Waist circumference was measured before and after 12 weeks. | 12 weeks | 
| Glucose Levels in Millimole Per Liter | Glucose levels were measured before and after 12 weeks. | 12 weeks | 
| Insulin Levels in Micro Unit Per Milliliter | Insulin levels were measured before and after 12 weeks. | 12 weeks | 
| Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) | Homeostasis model assessment of Insulin Resistance (HOMA-IR) was calculated before and after 12 weeks | 12 weeks | 
| Leptin Levels in Nano Grams Per Milliliter | Leptin levels were measured before and after 12 weeks. | 12 weeks | 
| Adiponectin Levels in Micro Grams Per Milliliter | Adiponectin levels were measured before and after the training. | 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Volume of Maximal Oxygen Consumption (VO2max) | Volume of maximal oxygen consumption (VO2max) was determined using a maximal treadmill test before and after 12 weeks. | 12 weeks | 
| Arterial Stiffness | Brachial-ankle Pulse Wave Velocity (m/s) was measured using applanation tonometry before and after 12 weeks. | 12 weeks | 
| Systolic Blood Pressure | Systolic blood pressure was measured before and after 12 weeks. | 12 weeks | 
| Diastolic Blood Pressure | Diastolic blood pressure was measured before and after 12 weeks. | 12 weeks | 
| Maximal Heart Rate |  | 12 weeks |