Effectiveness of Binge Eating Disorder Treatments

Study Overview
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Brief Summary
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This study will evaluate the long-term effectiveness of interpersonal psychotherapy, behavioral weight loss interventions, and guided self help treatments in treating binge eating disorder (BED).

Detailed Description
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BED is a serious condition that is associated with psychiatric comorbidity, psychosocial impairment, and obesity. Interpersonal psychotherapy (IPT), behavioral weight loss (BWL) interventions, and guided self help (GSH) treatments for BED have been evaluated, but the safest and most effective treatment has not yet been identified. This study will determine which of these three treatments is most effective in treating BED. Participants are stratified by negative affect subtype and are randomly assigned for 6 months to one of three treatment groups: IPT, BWL, or GSH. IPT focuses on current interpersonal problems which are hypothesized to increase negative affect and lead to binge eating. BWL interventions involve the adoption of weight loss inducing behaviors. GSH is a shortened version of cognitive behavioral therapy that focuses directly on eating behavior. IPT and BWL patients have 20 treatment sessions; those receiving GSH have 10 sessions. Assessments are made pre-treatment, post-treatment, and at 6, 12, 18, and 24 months after treatment is complete.

Official Title
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Effectiveness of Psychological Treatments for BED

Conditions
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Eating Disorders

Intervention / Treatment
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* Behavioral: Interpersonal Therapy
* Behavioral: Behavioral Weight Loss Treatment
* Behavioral: Guided Self Help


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: DSM-IV criteria for Binge Eating Disorder Body Mass Index (BMI) between 27 and 45 Exclusion criteria: Body Mass index > 45 Current psychosis Current bipolar disorder Alcohol or drug dependence within last 6-months

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Interpersonal Therapy<br>Interpersonal Therapy is a psychotherapy aimed at resolving interpersonal difficulties | Behavioral: Interpersonal Therapy<br>* 20 sessions of interpersonal therapy were provided over a 6-month period<br>* Other names: IPT;|
| Active Comparator: Behavioral Weight Loss Treatment<br>Behavioral Weight Loss Treatment is aimed solely at weight loss, however it has been shown to decrease binge eating | Behavioral: Behavioral Weight Loss Treatment<br>* 20 sessions of behavioral weight loss treatment were provided over a 6-month period<br>* Other names: BWL; Weight loss treatment;|
| Active Comparator: Guided Self Help<br>Guided Self-Help is a brief psychotherapy based on cognitive-behavioral treatment | Behavioral: Guided Self Help<br>* 10 sessions of guided self help were provided over a 6-month period<br>* Other names: GSH;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Binge eating | Rate of binge eating | Pre-treatment, 6, 12, and 24-months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Eating disorder psychopathology | Assessed by the Eating Disorder Examination | pre-treatment, 6, 12, 24 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Weight Loss