Efficacy Testing of Crassocephalum Rabens Extract Capsules

Study Overview
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Brief Summary
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This study is to investigate the improveing effects of the Crassocephalum rebens extract on skin conditions in normal people.

Official Title
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Efficacy Testing of Crassocephalum Rabens Extract Capsules

Conditions
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Aging

Intervention / Treatment
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* Dietary Supplement: Crassocephalum rabens extract


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age over 20 years Healthy people Exclusion Criteria: Non-volunteer Pregnant and lactating women Hypersensitivity to the assigned product Diagnosed with skin diseases, liver diseases, kinedy disease, and other severe diseases Cosmetic, drug, or food allergies Concurrent aesthetic treatments (e.g., intense pulse light, medical peelings, or laser therapy) Aceepted aesthetic treatments one month ago before the study Chronic sun exposure (over 3 hours/day) The members of the research team

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: A group (placebo)<br>Placebo | Dietary Supplement: Crassocephalum rabens extract<br>* dosage: a capsule (180 mg)/day; duration: 1 month<br>|
| Active Comparator: B group (experimental)<br>Crassocephalum rabens extract | Dietary Supplement: Crassocephalum rabens extract<br>* dosage: a capsule (180 mg)/day; duration: 1 month<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measurement of skin hydration | Corneometer CM825 is used to measure the moisture of upper cheek (unit: Corneometer® unit) | Week 0 | 
| Measurement of skin hydration | Corneometer CM825 is used to measure the moisture of upper cheek (unit: Corneometer® unit) | Week 4 | 
| Measurement of skin brightness | Chroma Meter MM500 is employed to measure the brightness of upper cheek (unit: L* value (L* range: 0-100)). | Week 0 | 
| Measurement of skin brightness | Chroma Meter MM500 is employed to measure the brightness of upper cheek (unit: L* value (L* range: 0-100)). | Week 4 | 
| Measurement of skin texture | Visia® skin analysis system is used to measure the skin texture of full face (unit: number of fine lines) | Week 0 | 
| Measurement of skin texture | Visia® skin analysis system is used to measure the skin texture of full face (unit: number of fine lines) | Week 4 | 
| Measurement of skin spots | Visia® skin analysis system is used to measure the skin spots of full face (unit: number of spots) | Week 0 | 
| Measurement of skin spots | Visia® skin analysis system is used to measure the skin spots of full face (unit: number of spots) | Week 4 | 
| Measurement of collagen content | DermaLab® Series SkinLab Combo (Cortex) is employed to measure skin collagen content of upper cheek (unit: collagen density) | Week 0 | 
| Measurement of collagen content | DermaLab® Series SkinLab Combo (Cortex) is employed to measure skin collagen content of upper cheek (unit: collagen density) | Week 4 | 
| Measurement of Crow's feet | Visia® skin analysis system is used to measure the skin spots of full face (unit: number of Visia® skin analysis system is used to measure the skin spots of full face (unit: number of fine lines around eyes) | Week 0 | 
| Measurement of Crow's feet | Visia® skin analysis system is used to measure the skin spots of full face (unit: number of Visia® skin analysis system is used to measure the skin spots of full face (unit: number of fine lines around eyes) | Week 4 | 
| Measurement of skin elasticity | Cutometer® is used to measure the skin elasticity of upper cheek (unit: mm) | Week 0 | 
| Measurement of skin elasticity | Cutometer® is used to measure the skin elasticity of upper cheek (unit: mm) | Week 4 | 
| Measurement of skin wrinkles | Visia® skin analysis system is used to measure the skin wrinkles of full face (unit: number of wrinkles) | Week 0 | 
| Measurement of skin wrinkles | Visia® skin analysis system is used to measure the skin wrinkles of full face (unit: number of wrinkles) | Weeks 4 | 
| Measurement of skin pores | Visia® skin analysis system is used to measure the skin spots of full face (unit: number of pores) | Week 0 | 
| Measurement of skin pores | Visia® skin analysis system is used to measure the skin spots of full face (unit: number of pores) | Week 4 |