Effects of Autologous Blood Injection Versus Platelet Rich Plasma on Chronic Plantar Fasciitis

Study Overview
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Brief Summary
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To explore effects of Autologous Blood Injection versus Platelet Rich plasma injection for treatment of chronic plantar fasciitis

Detailed Description
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After clinical diagnosis of patients with plantar fasciitis. Patients were divided into two groups. Group A (PRP injection group) and Group B (ABI group) were randomized according to web based block group randomization. Patients were evaluated prior to injection in terms of Health related quality of life scores related to foot and ankle diseases (AOFAS and FADI) and VAS. After injection at 1st, 3rd and 6th months HRQoL were compared between groups. Intra group evaluation for HRQoL were performed at f/up visits. Independent t test and repeated measure ANOVA test used for statistical analysis

Official Title
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Is There Any Advantage of PRP Over Autologous Blood Injection in the Treatment of Chronic Plantar Fasciitis? A Prospective Randomized Double Blinded Study

Conditions
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Plantar Fascitis

Intervention / Treatment
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* Biological: PRP injection
* Biological: ABI injection


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Participants who were diagnosed with chronic plantar fasciitis Nonresponded to o conservative treatment (stretching exercises, nonsteroidal anti-inflammatory drugs, and heel pads) for at least 6 weeks Patient should be able to understand the informed consent about type of treatment and blindness and randomization Visual analog scale pain higher than 5 (on a 10-point visual analog scale) Exclusion Criteria: previous history of any type of local injection treatment for heel pain history of surgery for heel pain, foot and ankle disorders, fractures Associated pathology involving the lower limb such as tarsal tunnel syndrome effusion of the ankle indicating an intra-articular disease Peroneal/Achilles/tibialis tendons pathology any obvious deformity of foot and ankle, Patients with systemic disorder like diabetes mellitus, ankylosing spondylitis rheumatoid arthritis, hematological disease, or gout Pregnancy Use of antiocoagulation -

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Group A<br>Platelet Rich Plasm (PRP) injection group | Biological: PRP injection<br>* Plantar fascia injection therapy with PRP<br>|
| Active Comparator: Group B<br>Autologous Blood injection (ABI) group | Biological: ABI injection<br>* ABI injection<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in Visual Analogue Scale (VAS) | Visual Analogue Scale 10 worst 0-1 best in terms of pain outcome | 0,1 st 3rd and 6th month; changes between time points will be assessed | 
| Changes in American Orthopaedic Foot & Ankle Society (AOFAS ) Score | American Orthopaedic Foot & Ankle Society (AOFAS) Clinical rating systems for the ankle-hindfoot, midfoot, hallux, and lesser toes Evaluation:0 worst 100 best | 0,1 st 3rd and 6th month; changes between time points will be assessed | 
| Changes in Foot and Ankle Disability Index (FADI) | Foot and Ankle Disability Index Evaluation:0 worst 100 best | 0,1 st 3rd and 6th month; changes between time points will be assessed | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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heel pain, platelet rich plasm, autologous blood injection