An Observational Study on the Relationship Between Tear Metabolomics and POD

Study Overview
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Brief Summary
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To explore the correlation between tear metabolomics and POD. The purpose of this study was to compare the results of tear metabolomics between POD and non-POD elderly patients undergoing abdominal surgery, to clarify the correlation between tear metabolomics and POD, and to find tear markers related to POD.

Official Title
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An Observational Study on the Relationship Between Tear Metabolomics and POD

Conditions
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Postoperative Delirium

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age 65-90 years old; ASA I-III; patients who plan to undergo elective abdominal surgery under general anesthesia; Volunteer to participate in this study and sign informed consent. Exclusion Criteria: patients with known mental illness or lack of communication or cognitive impairment before operation; severe vision, hearing, language impairment or other reasons unable to communicate with visitors; severe dysfunction of important organs such as heart, brain, lung, liver, kidney, etc.; long-term use of sedatives, antidepressants or alcoholism; patients with severe postoperative complications and admitted to intensive care unit; patients who refused or failed to complete the cognitive function test. patients who could not cooperate with the study for any other reason

Ages Eligible for Study
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Minimum Age: 65 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative delirium during the 3 adys-follow-up after anesthetic resuscitation | Postoperative delirium was tested with 3D-Confusion Assessment Method or Confusion Assessment Method-intensive care unit (0-4, higher scores means worse). The patient is determined to be postoperative delirium (ie, Confusion Assessment Method positive) if he/she fall ill quickly with confusion disorder, and with mental disorder or consciousness disorder. | From ending of the surgery to 3 days after anesthetic resuscitation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative delirium in the postanesthesia care unit | Postoperative delirium was tested with Confusion Assessment Method-intensive care unit. Postoperative delirium was tested with Confusion Assessment Method-intensive care unit (0-4, higher scores means worse outcome). The patient is determined to be postoperative delirium (ie, Confusion Assessment Method positive) if he/she fall ill quickly with confusion disorder, and with mental disorder or consciousness disorder. | From ending of the surgery to the time when discharge from postanesthesia care unit, an average of 30 minutes. | 
| Postoperative delirium on the first day after operation | Postoperative delirium was tested with 3D-Confusion Assessment Method (0-4, higher scores means worse outcome). The patient is determined to be postoperative delirium (ie, Confusion Assessment Method positive) if he/she fall ill quickly with confusion disorder, and with mental disorder or consciousness disorder. | 9：00-10：00 and 15：00-16：00 on The first day after operation | 
| Postoperative delirium on the second day after operation | Postoperative delirium was tested with 3D-Confusion Assessment Method (0-4, higher scores means worse outcome). The patient is determined to be postoperative delirium (ie, Confusion Assessment Method positive) if he/she fall ill quickly with confusion disorder, and with mental disorder or consciousness disorder. | 9：00-10：00 and 15：00-16：00 on The second day after operation | 
| Postoperative delirium on the third day after operation | Postoperative delirium was tested with 3D-Confusion Assessment Method (0-4, higher scores means worse outcome). The patient is determined to be postoperative delirium (ie, Confusion Assessment Method positive) if he/she fall ill quickly with confusion disorder, and with mental disorder or consciousness disorder. | 9：00-10：00 and 15：00-16：00 on The third day after operation |