linjc16/ctgov huggingface dataset:
Comparison of Translocator Protein Expression and Binding Activity in Normal Tissue Versus Non Melanotic Malignancy

Study Overview
=================
Brief Summary
-----------------
Translocator protein (TSPO) is a intracellular protein that is found primarily in the outer membrane of the mitochondria that is encoded by the TSPO gene. It has been found that TSPO expression in the skin correlates with cell proliferation and differentiation. Many studies have shown that TSPO overexpression in solid malignancies such as in ovarian cancer, colon cancer, and others, was also found to correlate with more aggressive cancer behavior. Working Hypothesis and Aims: Previous studies described an aberrant expression of TSPO levels in solid malignancies as compared to normal tissues. It is assumed that this aberration can be found in cuntaneous malignancies as well. The occurrence of this aberration may lead to the understanding of the mechanism of TSPO involment in the cutaneous malignancy, and in malignancies in general. Methods: The study will be carried out on surgically resected skin lesions suspected to SCC or BCC, which will be removed as part of the surgical routine treatment. The excision will be made in elliptic shape including the lesion and a part of normal skin surrounding it. A sample will be taken from the central part of the lesion and from the external extremity of the normal tissue. Western Blot will be conducted to detect the expression of TSPO. Binding activity with the TSPO specific ligandwill also be determined. Expected Results: We expect to observe either (a) a higher level of TSPO expression and a lower binding activity in malignant tissue compared with healthy control tissue or (b) a higher level of TSPO expression and a lower binding activity in malignant tissue compared with healthy control tissue. Importance: Until today, only a very small number of studies have examined TSPO in cutaneous malignancies, and these only examined TSPO expression. Our study will also measure the binding activity of TSPO in cutaneous malignant tissues compared to normal tissues

Official Title
-----------------
Comparison of the Expression Level of Translocator Protein (TSPO) and Binding Activity in Normal Cutaneous Tissue Versus Non Melanotic Cutaneous Malignancy.

Conditions
-----------------
Squamous Cell Carcinoma, Basal Cell Carcinoma

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Clinical diagnosis of Basal Cell Carcinoma or Squamous Cell Carcinoma Exclusion Criteria: Non-compliance with inclusion criteria
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Translocator Protein, Basal Cell Carcinoma, Squamous Cell Carcinoma, Malignancy
Analgesic Effects of Intravenous Paracetamol on Labor Pain

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine whether intravenous paracetamol is effective in treating labor pain.

Official Title
-----------------
Analgesic Effects of Intravenous Acetaminophen on Labor Pain

Conditions
-----------------
Labor Pain

Intervention / Treatment
-----------------
* Drug: Acetaminophen
* Drug: Meperidine


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: American Society of Anesthesiologists physical class I-II term patients (≥ 37 weeks of gestation) Exclusion Criteria: previous cesarean section hypertension, pre-eclampsia, eclampsia intra-uterine growth retardation intrauterine fetal death morbid obesity (body mass index ≥ 35) allergy to any of the study drugs

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Paracetamol 1<br> | Drug: Acetaminophen<br> <br> |
| Experimental: Paraceatmol 2<br> | Drug: Acetaminophen<br> <br> |
| Active Comparator: Meperidine<br> | Drug: Meperidine<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Visual analogue scale (VAS) score for pain | Patients who give written informed consent to participate will be entered into the study. Their VAS score will be determined every hour from the time of randomization until delivery of the baby. This time will vary from one patient to another depending on the duration of labor. | Up to 24 hours |
Muscle Activity and Sensation During Upright Partitioned Leg Exercise in COPD

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to determine if: the large muscles of the leg, activated during walking, are also active during scooting; whether scooting alters the relationship between leg and breathing heaviness; whether there is evidence of leg fatigue during scooting.

Official Title
-----------------
Leg Muscle Activity and Sensation During Upright Partitioned Exercise Compared to Walking: Propulsion of a 3-wheeled Scooter by Patients With Chronic Obstructive Pulmonary Disease

Conditions
-----------------
Chronic Obstructive Pulmonary Disease

Intervention / Treatment
-----------------
* Device: scooting


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosis of COPD: FEV1 < 80 % and FEV1/FVC < 0.7; Able to communicate in English Clinically stable Exclusion Criteria: predominant co-morbidities or treatments that might influence the results of exercise testing

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: scooting<br>incremental test to establish the relationship between leg and breathing heaviness with increasing demand (speed) during scooting | Device: scooting<br>* three-wheeled scooter (Monark 662, Monark Exercise AB Sweden) comprised of a single front wheel that provides steering and two rear wheels that create a wide base of support.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| slope of the relationship between self-reported breathing and leg heaviness using Borg scale | Borg scale ratings of breathing and leg heaviness will be measured during stepwise incremental speed exercise tests. The relationship between leg and breathing heaviness with increasing demand (speed) is quantified by the slope of the relationship between self-reported breathing and leg heaviness under each condition of customary walking and scooting. | 1 week | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Exercise Tolerance, Lung Diseases, Obstructive
Preterm Labor Prediction by Cervical Contour in Ultrasound

Study Overview
=================
Brief Summary
-----------------
Cervical length is a already known predictor for preterm labor. In this study the investigators want to examining the hypothesis that cervical curvature is also a predictor for preterm labor and that moderate transducer pressure influence cervical length. study population: 200 consecutive pregnant women between 14-34w, visiting in the ultrasound unit ether for routine screening or because of preterm labor. During their examination cervical length and curvature measurements will be taken. Another measurement will be taken after applying moderate cervical pressure. The investigators will compere cervical contour and pressure influence between groups and according to cervical length Demographic data will be taken at the time of recruitment and pregnancy outcome measures in a later telephone interview.

Conditions
-----------------
Preterm Labor

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: pregnancy Exclusion Criteria: cervical cerclage pre term rupture on membrane in current pregnancy unknown dating of pregnancy

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| preterm labor<br>pregnant women with signs of preterm labor: uterine contractions or cervical shortening | |
| control<br>pregnant women with no signs or symptoms of preterm labor | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| cervical curvature |  | 12 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
cervical length, cervical curvature
Pediatric Atorvastatin in Diabetes Intervention Trial (PADIT)

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine if Atorvastatin can improve blood vessel stiffness and blood vessel function in children 10-18 years old with Type 1 and Type 2 diabetes. Subjects will receive atorvastatin 20mg or placebo daily for 3 months and will then switch therapies for the next 3 months. Hypothesis: Atorvastatin will improve blood vessel function by decreasing arterial stiffness and improving blood flow.

Official Title
-----------------
Pediatric Atorvastatin in Diabetes Intervention Trial (PADIT)

Conditions
-----------------
Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus

Intervention / Treatment
-----------------
* Drug: Atorvastatin 20 mg daily for 3 months


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Type 1 Diabetes Mellitus (T1DM) or Type 2 Diabetes Mellitus (T2DM) for more than 1 year Age 10-18 years. Exclusion Criteria: Cardiovascular disease (CVD) Liver disease Pregnancy Use of cholesterol or triglyceride lowering drugs Perceived inability to comply with the study protocol Endocrinopathy other than diabetes

Ages Eligible for Study
-----------------
Minimum Age: 10 Years
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Atorvastatin 20 mg daily for 3 months|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Augmentation Index (arterial stiffness) |  |  | 
| ENDO-PAT (Peripheral Arterial Tone) score (endothelial function) |  |  | 
| Low density lipoprotein |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Urine microalbumin |  |  | 
| Pubertal stage |  |  | 
| Body mass index (BMI) |  |  | 
| Blood pressure |  |  | 
| Glycated hemoglobin (HbA1c) |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Diabetes, Children, Adolescents, Arterial Compliance, Physiology Cardiovascular Endothelium
Assessment of Changes in Renal Cortical and Medullary Blood Flow by Contrast Ultrasound

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine if contrast enhanced ultrasound (CEU) using microbubbles, is useful in assessing changes in kidney blood flow.

Official Title
-----------------
Assessment of Changes in Renal Cortical and Medullary Blood Flow by Contrast Ultrasound

Conditions
-----------------
Kidney

Intervention / Treatment
-----------------
* Drug: perflutren lipid microspheres


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy adults Males and females Ages 18-65 years old Exclusion Criteria: Pregnancy or lactation H/o kidney disease H/o congestive heart failure, ischemic heart disease, severe pulmonary disease or allergy to the drug H/o any cardiovascular disease Abnormal liver function (liver function tests out of specified ranges) Screening urinalysis which indicates infection or inflammation Taking regular medications (except for over-the-counter vitamins or hormonal contraceptives.) Taking supplements, like protein shakes Unwilling or unable to eat chicken (used as protein meal)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: perflutren lipid microspheres|1.3 ml in 30 ml of saline, infused into vein at 2ml / min and titrated for optimal image quality (not to exceed 10 ml/ min at any time).|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Efficacy of Lung Ultrasound in Monitoring Fluid Resuscitation in Chest Trauma Patients

Study Overview
=================
Brief Summary
-----------------
Efficacy of Lung ultrasound in monitoring fluid resuscitation in chest trauma patients with lung contusions

Detailed Description
-----------------
Trauma is a public health problem, associated to high morbidity and mortality, In Egypt the mortality from road traffic crashes is about 12000 victims per year. Chest trauma represents from 10% to 15% of the total number of traumas worldwide. According to ATLS protocol , early diagnosis and management of Chest trauma are essential. *Pulmonary contusion is found in 30-75% of cases of chest injury. point of care Ultrasound (POCUS) is Now a corner stone in Emergency management it can predict lung contusions within the first 72 hours after trauma. Recently, LUS Play a major role in assessment of the volume status in Trauma patients. B-lines score (BLS) has been validated as a lung ultrasound quantification of pulmonary congestion.The sum of all B-lines yields a score, B-lines score (BLS), which assess the degree of lung contusion. So that LUS may provide a valuable safety threshold to conduct fluid therapy.

Official Title
-----------------
Efficacy of Lung Ultrasound in Monitoring Fluid Resuscitation in Trauma Patients

Conditions
-----------------
Contusions Pulmonary, Lung Injury, Chest Trauma, Fluid Overload Pulmonary Edema

Intervention / Treatment
-----------------
* Other: Chest examination with Ultrasound device


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age > 18 years. chest trauma patients either with or without other injuries. Any patient with either blunt or penetrating chest trauma. Exclusion Criteria: - Patients in cardiac arrest. Patient refusal to participate Pregnant females.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Chest examination with Ultrasound device|Chest examination with Ultrasound device|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patients with lung contusion | Pulmonary edema will be detected by B_lines trauma patients with lung contusions | Upto 24 hours after trauma | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical correlation between Type & volume of Fluid & occurance of pulmonary edema. Correlation between severity of pulmonary lung contusion & The final disposition of the patients whatever (OR _another department _death….. etc) upto 24hr. | Follow up on degree of contusions after fluid resuscitation | For first 24 hours after trauma |
Embryo Developmental Capacity After Egg Banking in an Ovum Donation Program

Study Overview
=================
Brief Summary
-----------------
For an efficient egg banking system, an equally efficient cryopreservation strategy that ensures the viability of the oocytes is required. Very recently, improved and new methods are yielding satisfactory results. In particular, vitrification is providing excellent results for both survival and clinical outcomes. However, to evaluate the over all out come there are other parameters to be considered. In this sense, capacity development of embryos generated after oocyte vitrification is a major factor when assessing the viability of vitrified oocytes. Accordingly, the evaluation of the capacity of vitrified oocytes to reach the blastocyst stage will be highly valuable to fully assess the effectiveness of the egg banking and its contribution to ovum donation programs. The aim of this study is to evaluate the developmental capacity of vitrified oocytes by their ability to reach the blastocyst stage. The study includes oocyte donation cycles conducted with vitrified versus fresh oocytes.

Conditions
-----------------
Infertility

Intervention / Treatment
-----------------
* Other: IVF
* Other: Oocyte Vitrification


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 18-35 year old Normal response (8-15 follicles) to long protocol of ovarian stimulation with hCG Donors with normal menstrual cycles (21-35 day duration) Donors with BMI between 18-25 Kg/m2 Exclusion Criteria: Donors with two or more previous miscarriages Polycystic ovary syndrome Donors with antecedents of poor embrionary quality not attributed to masculine factor Donors with drop of estradiol of more than 10% or estradiol plateau. Donors with a high response>20 oocytes and or levels above 3000pg/ml of estradiol the day of the administration of chorionic gonadotrophin (hCG)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: fresh<br>Embryo transfer with fresh oocytes | Other: IVF<br> <br> |
| Experimental: Frozen<br>Embryo transfer with vitrified oocytes | Other: Oocyte Vitrification<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mean outcome measures will be survival, fertilization and blastocyst rates and clinical outcome. |  | 10 months |
Effects of the Intensity and the Timing of the Physical Activity in a Primary School

Study Overview
=================
Brief Summary
-----------------
In natural environment, the moderate-intensity break will allow a reduction of the caloric intake at the dinner more important than for the light-intensity break In natural environment, the break taken juste before dinner will allow a reduction of the caloric intake at the diner more important than earlier in the day.

Conditions
-----------------
Energy Intake

Intervention / Treatment
-----------------
* Behavioral: Intensity and timing of exercise


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Children aged of approximately 5 years old of a of a nursery class of the school Jacques-Barclay, St-Mathieu Exclusion Criteria: Present allergy of the foods in the lunch having a handicap or a limitation that avoid walking, running or tkaing part of the physcial activity courses at the school. Having a potential surgery Having a metabolic disease or taking drugs that could have an impact on the results of the study Be vegetarian Having intestinal disorders

Ages Eligible for Study
-----------------
Minimum Age: 4 Years
Maximum Age: 6 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Lifestyle counseling<br> | Behavioral: Intensity and timing of exercise<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Caloric intake at the breakfast, lunch and diner (kj) |  | 3 days per condition | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Anthropometric measures |  | At preliminary visit |