REward SYSTem in Autism Spectrum Disorder and Addictive Disorder

Study Overview
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Brief Summary
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An MRI Study in Subjects with Autism Spectrum Disorder and Subjects with Food Addictive Disorder compared to healthy volunteers.

Detailed Description
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An MRI Study in Subjects with Autism Spectrum Disorder and Subjects with Food Addictive Disorder compared to healthy volunteers, where pathophysiology common to both disorders, based on a dysfunction of the reward system. The project we propose aims to explore the neural networks underlying these alterations in patients suffering from autism or addictive disorder.

Official Title
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Stimuli Sociaux et Non-sociaux du système de récompense : Une étude en IRM Chez Des Sujets Avec Trouble du Spectre de l'Autisme et Des Sujets Avec un Trouble Addictif à l'Alimentation. - RESYSTAA

Conditions
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Autism Spectrum Disorder

Intervention / Treatment
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* Diagnostic Test: MRI
* Diagnostic Test: EEG


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Arm A ˗ Concerning ASD patients: Adult carrying the diagnosis of ASD (DSM-5, ADOS, ADI-R criteria) Arm B ˗ Concerning FAD patients: Adult diagnosed with FA presenting with food addiction (DSM-5, YFAS 2.0, BES >= 18 criteria). Arm C ˗ Concerning healthy volunteers : Adult with no neurological and psychiatric history , absence of progressive somatic pathologies or with vital risk. For all participants: Age greater than or equal to 18 years old Without intellectual delay (IQ > 70). Able to understand and apply the instruction when an active task is proposed, according to the estimate of the investigator. Free, express, informed and written consent of the participant. Participant affiliated to a social security scheme Exclusion Criteria: Neuromotor disorders. Visual disturbances not corrected or incompatible with MRI. Known epilepsy. Current substance use disorder with emotional distress/significant impact on functional outcome Rare genetic syndrome. Contraindications to MRI (other than body circumference) For women of childbearing age: negative urine or blood pregnancy test Person subject to a measure of judicial protection (safeguard of justice, curatorship, guardianship or family authorization)

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Pilot study, monocentric open in three parallel groups (ASD, AD and healthy volunteers).
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Autism Spectrum Disorder<br>Characterized by two main diagnostic criteria: a socio-emotional deficit via a defect in communication and social reciprocity, and a behavioral deficit which manifests itself in repetitive behavioral patterns (stereotypes), restricted interests and/or activities. | Diagnostic Test: MRI<br>* an fMRI measurement of the BOLD physiological signal for sensory responses<br>* Other names: Functionnal MRI;Diagnostic Test: EEG<br>* These tests, through videos with a social or non-social content (human presence or absence on the stereoscopic projection), will allow us to study two types of sensorialities (visual and interoceptive). Thus, it will be possible to obtain inter- and exteroceptive profiles of the participants, a direct reflection of the processing of the internal bodily sensations of the body.<br>* Other names: Electro Encephalography;|
| Active Comparator: Food Addictive Disorders<br>Characterized by regroup substance use disorders and behavioral addictions, are characterized in particular by the repeated occurrence of compulsive behavior and impaired social functioning | Diagnostic Test: MRI<br>* an fMRI measurement of the BOLD physiological signal for sensory responses<br>* Other names: Functionnal MRI;Diagnostic Test: EEG<br>* These tests, through videos with a social or non-social content (human presence or absence on the stereoscopic projection), will allow us to study two types of sensorialities (visual and interoceptive). Thus, it will be possible to obtain inter- and exteroceptive profiles of the participants, a direct reflection of the processing of the internal bodily sensations of the body.<br>* Other names: Electro Encephalography;|
| Placebo Comparator: Healthy volonteers<br>Adult without neurological and psychiatric history, absence of progressive somatic pathologies or with vital risk. | Diagnostic Test: MRI<br>* an fMRI measurement of the BOLD physiological signal for sensory responses<br>* Other names: Functionnal MRI;Diagnostic Test: EEG<br>* These tests, through videos with a social or non-social content (human presence or absence on the stereoscopic projection), will allow us to study two types of sensorialities (visual and interoceptive). Thus, it will be possible to obtain inter- and exteroceptive profiles of the participants, a direct reflection of the processing of the internal bodily sensations of the body.<br>* Other names: Electro Encephalography;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood Oxygene Level Dependent (BOLD) MRI signal | Measurement in fMRI of the BOLD signal for each condition (interest, addiction, social) will be carried out in order to highlight the possible alterations of the reward system, in particular at the level of the striatum in terms of cerebral activation for each of the groups of subjects. (FAD, ASD and HV). | At inclusion | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Tolerance to an MRI examination for FAD with overweight or obesity | For the tolerance to an MRI examination for FAD with overweight or obesity: feedback on their experience in MRI. | At inclusion | 
| Regulation of sensory, an fMRI measurement of the BOLD physiological signal for sensory responses (sensory block) in terms of brain activation in patients | Regulation of sensory, an fMRI measurement of the BOLD physiological signal for sensory responses (sensory block) in terms of brain activation in patients with FAD compared to ASD subjects and healthy volunteers. | At inclusion | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Autism; MRI;Addictive disorders