Split Wound Comparison of Trichophytic Closure Techniques for Donor Site in Hair Transplantation

Study Overview
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Brief Summary
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This study aim to compare cosmetic results between 3 trichophytic closure techniques for donor site (the trimming of upper, lower and both edge of linear incision) in hair transplantation.

Detailed Description
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Strip harvesting technique, a conventional hair transplantation procedure, is widely used in the treatment of androgenetic alopecia for more than half a century. It provides less time-consuming, more feasible and more cost-effective comparing with follicular unit extraction (FUE) technique. However, linear scar at the donor site is also introduced. The latest method to fine the scar at the donor site was invented and known as 'Trichophytic closure technique'. It can be done by trimming upper or lower wound edge for about 1 millimeter (as Fig.1) before wound closure. Then the linear scar will be less visible after hair growth. Anyway, there is no exactly wound edge (upper, lower or both) that recommended for the excellent cosmetic results without any severe side effects. Therefore, this study was designed to determine which is the best trichophytic closure technique. This research is a pilot, split-wound comparison study of trichophytic closure techniques for donor site in hair transplantation.10 males, aged ≥ 25 years, who require strip harvesting follicular unit transplantation in the treatment of androgenetic alopecia will be enrolled. Preoperative and perioperative process will be conducted as standard procedure except wound closure technique. Each incision wound of donor site will be equally divided into 3 parts (marked with tattoos as Fig.2) and each part will be randomly treated with different trichophytic closure techniques as below. The 1-millimetre trimming of upper edge of linear incision before wound closure The 1-millimetre trimming of lower edge of linear incision before wound closure The 0.5-millimetre trimming of both edge of linear incision before wound closure For evaluation, we have planned to assess both cosmetic results and side effects as shown in the table. ( Table 1 - image file ) After data collecting process, we have planned to analyze the demographic data, rate of infection and other side effects in a descriptive manner. However, the evaluation for cosmetic results will be analyzed by paired t-test in the same technique at different follow up period and by one-way ANOVA between each technique at the same follow up period.

Official Title
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Split Wound Comparison of Trichophytic Closure Techniques for Donor Site in Hair Transplantation

Conditions
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Androgenetic Alopecia

Intervention / Treatment
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* Procedure: Trichophytic closure upper edge trimming
* Procedure: Trichophytic closure lower edge trimming
* Procedure: Trichophytic closure both edge trimming


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Male Age of 25 or more Diagnosis of androgenetic alopecia Do not response to conventional treatment and undergo hair transplantation surgery Exclusion Criteria: Have skin lesion at donor site Psychological disturbance including trichotillomania Anti-HIV positive

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: upper edge trimming<br>Surgery: trichophytic closure The 1-millimetre trimming of upper edge of linear incision before wound closure | Procedure: Trichophytic closure upper edge trimming<br>* 'Trichophytic closure technique' can be done by trimming upper or lower wound edge for about 1 millimeter (as Fig.1) before wound closure. Then the linear scar will be less visible after hair growth. Anyway, there is no exactly wound edge (upper, lower or both) that recommended for the excellent cosmetic results without any severe side effects. Therefore, this study was designed to determine which is the best trichophytic closure technique.<br>* Other names: upper edge trimming;|
| Experimental: lower edge trimming<br>Surgery: trichophytic closure The 1-millimetre trimming of lower edge of linear incision before wound closure | Procedure: Trichophytic closure lower edge trimming<br>* 'Trichophytic closure technique' can be done by trimming upper or lower wound edge for about 1 millimeter (as Fig.1) before wound closure. Then the linear scar will be less visible after hair growth. Anyway, there is no exactly wound edge (upper, lower or both) that recommended for the excellent cosmetic results without any severe side effects. Therefore, this study was designed to determine which is the best trichophytic closure technique.<br>* Other names: lower edge trimming;|
| Experimental: Both edge trimming<br>Surgery: trichophytic closure The 0.5-millimetre trimming of both edge of linear incision before wound closure | Procedure: Trichophytic closure both edge trimming<br>* 'Trichophytic closure technique' can be done by trimming upper and lower wound edge for about 0.5 millimeter (as Fig.1) before wound closure. Then the linear scar will be less visible after hair growth. Anyway, there is no exactly wound edge (upper, lower or both) that recommended for the excellent cosmetic results without any severe side effects. Therefore, this study was designed to determine which is the best trichophytic closure technique.<br>* Other names: both edge trimming;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changing of scar on the donor site during time courses | Hair density Width of scar Global photographic view (taken with Cannon 60D 18.0 Megapixels 100 mm macro lens) Uninvolved dermatologist's assessment * Self assessment* | 1 week, 4 week, 12 week, 24 week | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of Participants with wound complication | Record number of patient who have wound problem example Hematoma, Wound separation, wound Infection, etc. | immediate, 1week, 4week, 12week, 24week | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Trichophytic closure, hair transplantation, donor site, Androgenetic alopecia