Causes of Visual Loss in Retinal Disease

Study Overview
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Brief Summary
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This is a study of visual outcomes in retinal disease that seeks to identify the causes of visual loss. This data will be used to predict which patients are at risk of losing vision and how they can be better treated.

Detailed Description
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This is a study of visual outcomes in retinal disease. It is an observational study of patients who have been seen in the retinal clinic, and involves a retrospective casenotes analysis to identify patients who have suffered visual loss and the reason for that visual loss. These data will be analysed to enable the identification of factors that predict visual loss in patients who present earlier in the course of their disease.

Official Title
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Observational Study of Visual Outcomes in Retinal Disease

Conditions
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Uveitis, Scleritis

Intervention / Treatment
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* Drug: Immunosuppressive Agents


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients with a diagnosis of ocular inflammation patients with at least 6 months of follow-up Exclusion Criteria: patients without a diagnosis of ocular inflammation patients with less than 6 months of follow-up

Ages Eligible for Study
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Minimum Age: 16 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with ocular inflammation<br>Patients with ocular inflammation | Drug: Immunosuppressive Agents<br>* Treatment with systemic corticosteroids and/or immunosuppressive agents Treatment with local corticosteroids and other drugs<br>* Other names: Rituximab;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Visual acuity at 5 years | Best-corrected visual acuity at 5 years | 5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Visual acuity at 10 years | Best corrected visual acuity at 10 years | 10 years | 
| Source of referral | Categorised as A&E/GP referral/Optician referral/Tertiary referral | Baseline | 
| Laterality | Categorised as: Right eye/Left eye/Bilateral | Baseline | 
| Anatomical diagnosis | Cateogorised as: Acute anterior uveitis / Chronic anterior uveitis / Fuchs heterochromic cyclitis / Intermediate uveitis / Pars planitis / Posterior Uveitis / Panuveitis / Episcleritis / Scleritis | Baseline | 
| Aetiological diagnosis | Diagnosed as: Viral / Bacterial / Fungal / Parasitic / Inflammatory / Malignant | Baseline | 
| Associated systemic disease | Any associated systemic disease, e.g. HLA-B27 associated disease, Behcet's disease, multiple sclerosis, Vogt-Koyanagi-Harada syndrome, rheumatoid arthritis, collagen vascular disease, tuberculosis, granulomatosis with polyangiitis | Baseline | 
| Complications of disease and causes of visual loss at 5 years | Categorised into: Corneal clarity problems / cataract / vitreous debris / retinal detachment / cystoid macular edema / retinal pigment epithelium atrophy / macular scarring / epiretinal membrane / macular hole / steroid response / glaucoma / other optic neuropathy / hypotony & phthisis / other | 5 years | 
| Complications of disease and causes of visual loss at 10 years | Categorised into: Corneal clarity problems / cataract / vitreous debris / retinal detachment / cystoid macular edema / retinal pigment epithelium atrophy / macular scarring / epiretinal membrane / macular hole / steroid response / glaucoma / other optic neuropathy / hypotony & phthisis / other | 10 years | 
| Complications of disease and causes of visual loss | Categorised into: Corneal clarity problems / cataract / vitreous debris / retinal detachment / cystoid macular edema / retinal pigment epithelium atrophy / macular scarring / epiretinal membrane / macular hole / steroid response / glaucoma / other optic neuropathy / hypotony & phthisis / other | Up to 10 years | 
| Treatment measures employed | Categorised into: Topical treatment / periocular steroid / intraocular steroid / intraocular other agent / Glaucoma treatment / systemic immunosuppressive agents | Up to 10 years | 
| Complications of disease and treatment | Categorised into: Local complications: Raised intraocular pressure / cataract / endophthalmitis / other Systemic complications: Diabetes / hypertension / cholesterol / liver function / bone density loss / other | Up to 10 years | 
| Surgical procedures | List and dates of any intraocular surgery performed during the study | Up to 10 years | 
| Burden of disease - appointments | Number of outpatient appointments over the course of the study | Up to 10 years | 
| Burden of disease - outpatient procedures | Number of outpatient procedures over the course of the study | Up to 10 years | 
| Burden of disease - inpatient procedures | Number of inpatient procedures over the course of the study | Up to 10 years | 
| Blind registration | Year of any registration as partially sighted or blind | Up to 10 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Scleritis, Uveitis