Exercise Testing in Diseases and Health

Study Overview
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Brief Summary
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Cardiopulmonary exercise test (CPET) is a helpful tool for evaluation of aerobic exercise capacity and tolerance for variety of population. CPET provides a full assessment of the physiologic responses of the pulmonary, cardiovascular, muscular, and cellular oxidative systems to exercise. The test progression include a incremental stepwise (on treadmill) or ramp control protocol (on bike ergometer ) to exhaustion. Measurement of respiratory gas exchange i.e. oxygen uptake, carbon dioxide, minute ventilation, other variables while monitoring ECG, blood pressure, pulse oximetry and exertion perceived (Borg Scale) during an incremental test . Aim: To compere exercise responses for maximal exercise testing with different population.

Detailed Description
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Each participants will conducted an exercise test on treadmill using Modified Bruce Protocol) or cycle ergometer. Quark CPET metabolic cart (Cosmed, Rome, Italy) will be use to collect and analysis gas exchange. 10 minute after the graded exercise test Supra maximal exercise test (SMT) will be done for 2 minutes one stage (treadmill protocol) or 10% at cycle protocol higher than highest load achieved in the incremental test. all outcome measurement will be collected. Exercise tolerance and responses will be assess using the data of : pulmonary gas exchange; cardiovascular performance, and skeletal muscle metabolism.

Official Title
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Cardio Pulmonary Exercise Testing (CPET) in Diseases and Health

Conditions
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Exercise Test

Intervention / Treatment
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* Diagnostic Test: Maximal exercise test


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: *Patient who invited to the clinic to do incremental maximal exercise test or healthy *Participants with no known significant health problems. Exclusion Criteria: Acute fever Acute myocardial infarction within 2 to 3 days. Unstable angina not previously stabilized by medical therapy. Uncontrolled cardiac arrhythmias causing symptoms or hemodynamic compromise. Symptomatic severe aortic stenosis. Uncontrolled symptomatic heart failure. Inability to perform exercise Orthopedic impairment severely compromising exercise performance.

Ages Eligible for Study
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Minimum Age: 4 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Exercise Test<br>maximal and anaerobic threshold cardiopulmonary parameters | Diagnostic Test: Maximal exercise test<br>* Each participants will conduct a spirometry test and exercise test on treadmill (using Modified Bruce Protocol) or cycle ergometer. Quark CPET metabolic cart (Cosmed, Rome, Italy) will be used to collect and analysis gas exchange, ECG, gas volume in addition rating of perceived exertion will be asked.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Maximal Oxygen consumption | the maximum amount of oxygen that an individual can utilize during intense or maximal exercise. | through study completion, an average of 1 year | 
| Maximal Heart rate | the maximum heart rate achieved during intense or maximal exercise. | through study completion, an average of 1 year | 
| Maximal Blood pressure | the blood pressure in the end of intense or maximal exercise. | through study completion, an average of 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ventilation Anaerobic Threshold | Ventilatory Threshold (VT) describes the inflection point for ventilation during an incremental exercise test. | through study completion, an average of 1 year |