Visual Perception in Preterm Infants

Study Overview
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Brief Summary
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We aim to increase our knowledge of the impact of preterm birth on the maturation of the visual and auditory systems and on the development of multisensory perception Specifically, we aim to evaluate the preterm infants' capabilities of detection and discrimination of different visual and auditory stimuli according to gestational age, post menstrual age and the duration of the postnatal life. A secondary aim is to compare this competencies in preterm and full term control art term equivalent age. The final aim is to optimize the hospital environment in order to make it correspond to the expectations and sensory abilities of very preterm infants. Our hypothesis is that preterm birth exposes the infants to numerous atypical stimuli which could accelerate the processes of sensory maturation

Official Title
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Sensory Maturation of Preterm Infants: From Visual Sensitivity to Multisensory Perception

Conditions
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Pediatrics

Intervention / Treatment
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* Behavioral: collection data
* Behavioral: IRM


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Newborn less than 32 weeks PMA hospitalized in the Hospital of Hautepierre, Strasbourg, France) Consent obtained from both parents Social insurance coverage Exclusion Criteria: Any known malformation Brain lesions discovered on brain ultrasound (Intra-Ventricular hemorrhage grade III or IV periventricular Leukomalacia). Unstable clinical State Retinopathy Of Prematurity stage> 2 or in zone 1 Family history of abnormal color vision. Abnormalities in auditory testing Transfer to another hospital expected before 40 week PMA

Ages Eligible for Study
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Minimum Age: 23 Weeks
Maximum Age: 42 Weeks

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: preterm infants<br>physiological data collection, behavioral, cerebral hemodynamics, physical environmental newborns studied in response to visual stimuli / auditory or visual-auditory calibrated | Behavioral: collection data<br> <br> Behavioral: IRM<br> <br> |
| Other: term infants<br>physiological data collection, behavioral, cerebral hemodynamics, physical environmental newborns studied in response to visual stimuli / auditory or visual-auditory calibrated | Behavioral: collection data<br> <br> Behavioral: IRM<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| visual stimulus detection with luminance | in green condition in hospital, luminance ( 100 and 300 lux ) and color (blue- red-yellow- white) variables | 3 months | 
| auditory stimulus detection with parents voice | use parents voice, pure sound of 500 Hz | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| behavioral responsiveness to visual stimuli calibrated collected from video recordings | Evaluate the facial expression of the imitation abilities in preterm and term neonates at term. The interpretation of the behavioral responses of newborns to mimic presented by the experimenter will be working independently by two observers with a coding grid | 3 months |