Retrospective and Prospective Observational Study of MRI Changes in Bone and Visceral Lesions of Patients With Type 1 Gaucher Disease Treated With VPRIV® (Velaglucerase Alfa)

Study Overview
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Brief Summary
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This study with standardized reading MRIs, will provide for the first time objective and quantified data on organomegaly (liver and spleen volumes) as well as bone alteration (Bone Marrow Burden11) of French patients treated with VPRIV®. These data will help to better assess the impact of this treatment on these parameters. The result of this study will also answer in part to the request of the French Transparency Commission (CT: Commission de Transparence) of the French National Health Authority to provide them with data of French patients treated with VPRIV®.

Detailed Description
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All data entered will be used for analysis purposes and results will be submitted to inform regulatory agencies. Patient care and management is freely determined by the participating physician, in the framework of an observational study reflecting the daily medical practice. The clinical data, the results of routine clinical and laboratory testing that are part of standard medical care for patients with Gaucher disease will be collected from the medical record of the patient : Socio-demographic characteristics History of the disease and context of diagnosis Medical background MRI: abdominal and bone, as defined below Clinical data available in the range from 3 months before or after each MRI Biological data available in the range from 3 months before or after each MRI Treatment with VPRIV® (velaglucerase alfa), including the doses and regimens. The MRI images collected during the study: The MRIs performed in the patient's usual medical follow-up for its Gaucher disease (abdominal MRI (liver and spleen) and bone MRI (back injury pelvis, lower limbs) and / or whole-body MRI) will be collected. Among the MRIs available in the patient's medical records, MRIs will be collected as following: Reference MRI: MRI closest to the date of initiation of VPRIV® in the five years preceding the start of treatment or within three months after initiation of VPRIV®. MRIs of the retrospective phase of the study: All MRIs available between the reference MRI and the inclusion date of the patient. MRIs of the prospective phase of the study: all the MRIs that will be realized during the prospective phase of the study, that is to say during the year following the date patient inclusion in the study Second reading of the MRI The collected MRIs will be subject to a second reading, which will be conducted centrally by a medical image processing center (BioClinica). This second reading of MRIs will particularly provide quantitative data not available initially in the patient records, such as Bone Marrow Burden (BMB) score at the lumbar spine and femur, and liver and spleen volumes. In case the second reading provides additional data to the first reading, as any new comments or discordant diagnosis, the investigating doctor will integrate these data as soon as he has knowledge of them in the medical care of the patient. MRI collection and transmission Except the data from the second reading of MRIs by BioClinica, all data defined above, will be collected in the case report of the study, from the patient's medical record. For the second centralized reading of the MRIs, the MRIs will be transmitted as follows: the investigation center will make a copy on Compact Disc - Read Only Memory (CD-ROM) of each MRI collected for the study needs, and will replace the identity the patient by an identification number whose correspondence with the patient's identity is only known by the investigation center. This patient identification number will be predefined and attributed to the patient's MRI when the patient is included in the study. Copies of MRIs and coded will be sent securely at BioClinica center for analysis. In case of connection failure from the participating centers, MRI scans will be sent by post. Data from this second reading by BioClinica will be retrieved for analysis. The results of the second reading by BioClinica will be forwarded to investigation center, which will include them in the patient's record.

Official Title
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Retrospective and Prospective Observational Study of MRI Changes in Bone and Visceral Lesions of Patients With Type 1 Gaucher Disease Treated With VPRIV® (Velaglucerase Alfa)

Conditions
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MRI, Gaucher Disease, Type 1

Intervention / Treatment
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* Other: MRI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients of any age or gender with confirmed diagnosis of type 1 Gaucher disease, Patients treated with VPRIV® at the beginning of the study. Prior starting VPRIV® patients could be either treatment naïve or previously treated with any other Gaucher treatment than VPRIV® Patients should have one MRI data in the 5 previous years before starting VPRIV® Treatment (up to 3 months after initiation of VPRIV® Informed written consent obtained from the patient, and/or patient's parent(s), and/or legal representative. Assent, if old enough to grant, will be obtained from all patients under the age of 18 years Exclusion Criteria: Patients for whom MRI is contra-indicated Patients who did not had an MRI during the five years prior to the initiation of treatment with VPRIV® or within three months after initiation of VPRIV®. Patients included in an ongoing clinical trial where the product is blinded
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Study Population<br>Patients of any age or gender with confirmed diagnosis of type 1 Gaucher disease, treated with VPRIV® at the beginning of the study. Patients should have one MRI data in the 5 previous years before starting VPRIV® treatment (up to 3 months after initiation of VPRIV®. | Other: MRI<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The change over time between the baseline MRI and the follow-up MRIs, of the BMB score weighted at T1 measured at the femur. | To describe changes in bone disease in femur in Gaucher's disease patients treated with Velaglucerase alfa measured by MRI. The primary endpoint is the change over time between the baseline MRI and the follow-up MRIs, of the BMB score weighted at T1 measured at the femur. | 2 YEARS | 
| The change over time between the baseline MRI and the follow-up MRIs, of the BMB score weighted at T2 measured at the femur. | To describe changes in bone disease in femur in Gaucher's disease patients treated with Velaglucerase alfa measured by MRI. The primary endpoint is the change over time between the baseline MRI and the follow-up MRIs, of the BMB score weighted at T2 measured at the femur. | 2 YEARS | 
| The change over time between the baseline MRI and the follow-up MRIs, of the BMB score weighted at T1 measured at the lumbar spine. | To describe changes in bone disease in lumbar spine in Gaucher's disease patients treated with Velaglucerase alfa measured by MRI. The primary endpoint is the change over time between the baseline MRI and the follow-up MRIs, of the BMB score weighted at T1 measured at the lumbar spine. | 2 YEARS | 
| The change over time between the baseline MRI and the follow-up MRIs, of the BMB score weighted at T2 measured at the lumbar spine. | To describe changes in bone disease in lumbar spine in Gaucher's disease patients treated with Velaglucerase alfa measured by MRI. The primary endpoint is the change over time between the baseline MRI and the follow-up MRIs, of the BMB score weighted at T2 measured at the lumbar spine. | 2 YEARS | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Describe socio-demographic characteristics of patients : age | To describe the socio-demographic of patients : age | 2 YEARS | 
| Describe socio-demographic characteristics of patients : sex | To describe the socio-demographic of patients : sex | 2 YEARS | 
| Describe socio-demographic characteristics of patients : occupation | To describe the socio-demographic of patients : occupation | 2 YEARS | 
| Clinical evolution of patients :weight (kg) | To describe the clinical evolution of patients : weight (kg) | 2 YEARS | 
| Clinical evolution of patients : height (cm) | To describe the clinical evolution of patients : height (cm) | 2 YEARS | 
| Clinical evolution of patients : absence or presence (mild, moderate or severe) asthenia | To describe the clinical evolution of patients : absence or presence (mild, moderate or severe) asthenia | 2 YEARS | 
| Clinical evolution of patients : abdominal pain | To describe the clinical evolution of patients : abdominal pain | 2 YEARS | 
| Clinical evolution of patients : chronic bone pain | To describe the clinical evolution of patients : chronic bone pain | 2 YEARS | 
| Clinical evolution of patients : bone crises | To describe the clinical evolution of patients : bone crises | 2 YEARS | 
| Clinical evolution of patients : bleeding and hemorrhagic syndrome | To describe the clinical evolution of patients : bleeding and hemorrhagic syndrome | 2 YEARS | 
| Clinical evolution of patients : pulmonary impairment | To describe the clinical evolution of patients : pulmonary impairment | 2 YEARS | 
| Clinical evolution of patients : neurological impairment | To describe the clinical evolution of patients : neurological impairment | 2 YEARS | 
| Clinical evolution of patient : absence or presence of hepatomegaly | To describe the clinical evolution of patients : absence or presence of hepatomegaly, with the extent of the arrow (medio-clavicular line) (cm) | 2 YEARS | 
| Clinical evolution of patients : absence or presence of splenomegaly | To describe the clinical evolution of patients : absence or presence of splenomegaly, with the extent of the costal overhang (cm) | 2 YEARS | 
| Evolution of the parameters measured by MRI : Bone alterations | To describe the evolution of the parameters measured by MRI : bone alterations (spine, pelvis, femurs, tibias and other symptomatic localization). Absence or presence of bone lesions and their locations: bone infiltration, cortical thinning, osteonecrosis, bone infarction, stroke sequelae, vertebral compression, fracture or other bone disease. If possible, compare the evolution of MRI parameters between treatment-naive patients and patients previously treated with another specific treatment for Gaucher disease at the baseline MRI. | 2 YEARS | 
| Evolution of the parameters measured by MRI : Liver evaluation : absence or presence of hepatomegaly with the extent of the arrow (medio-clavicular line) (cm). | To describe the evolution of the parameters measured by MRI : Visceral involvement : Liver evaluation criteria MRI : absence or presence of hepatomegaly, with the extent of the arrow (medio-clavicular line) (cm). If possible, compare the evolution of this MRI parameters between treatment-naive patients and patients previously treated with another specific treatment for Gaucher disease at the baseline MRI. | 2 YEARS | 
| Evolution of the parameters measured by MRI : Liver evaluation : evolution of the liver volume (m3). | To describe the evolution of the parameters measured by MRI : Liver evaluation criteria MRI : evolution of the liver volume (m3). If possible, compare the evolution of this MRI parameters between treatment-naive patients and patients previously treated with another specific treatment for Gaucher disease at the baseline MRI. | 2 YEARS | 
| Evolution of the parameters measured by MRI : Spleen evaluation : absence or presence of splenomegaly | To describe the evolution of the parameters measured by MRI : Spleen evaluation MRI : absence or presence of splenomegaly. If possible, compare the evolution of this MRI parameters between treatment-naive patients and patients previously treated with another specific treatment for Gaucher disease at the baseline MRI. | 2 YEARS | 
| Evolution of the parameters measured by MRI : Spleen evaluation : evolution of the extent of the costal overhang (cm) | To describe the evolution of the parameters measured by MRI : Spleen evaluation MRI : evolution of the extent of the costal overhang (cm). If possible, compare the evolution of this MRI parameters between treatment-naive patients and patients previously treated with another specific treatment for Gaucher disease at the baseline MRI. | 2 YEARS | 
| Evolution of the parameters measured by MRI : Spleen evaluation : absence or presence of splenomegaly. | To describe the evolution of the parameters measured by MRI : Spleen evaluation MRI : absence or presence of splenomegaly. If possible, compare the evolution of this MRI parameters between treatment-naive patients and patients previously treated with another specific treatment for Gaucher disease at the baseline MRI. | 2 YEARS | 
| Evolution of the parameters measured by MRI : Spleen evaluation : evolution of the spleen volume (m3) | To describe the evolution of the parameters measured by MRI : Spleen evaluation MRI : evolution of the spleen volume (m3). If possible, compare the evolution of this MRI parameters between treatment-naive patients and patients previously treated with another specific treatment for Gaucher disease at the baseline MRI. | 2 YEARS | 
| Evolution of the parameters measured by MRI : Presence or absence of myocardia alterations | To describe the evolution of the parameters measured by MRI : Presence or absence of myocardial, nodules, fibrosis, vesicular stones or other alterations. If possible, compare the evolution of MRI parameters between treatment-naive patients and patients previously treated with another specific treatment for Gaucher disease at the baseline MRI. | 2 YEARS | 
| Evolution of Biological parameters : hemoglobin (g/dl) | To describe the evolution of biological parameters : hemoglobin (g/dl) | 2 YEARS | 
| Evolution of Biological parameters : leukocytes (cells/mm3) | To describe the evolution of biological parameters : leukocytes (cells/mm3) | 2 YEARS | 
| Evolution of Biological parameters : platelets (mm3) | To describe the evolution of biological parameters : platelets (mm3) | 2 YEARS | 
| Evolution of Biological parameters : Angiotensin Converting Enzyme (ACE) (U/l) | To describe the evolution of biological parameters : ACE (angiotensin converting enzyme (U/l) | 2 YEARS | 
| Evolution of Biological parameters: ferritin (mg/l) | To describe the evolution of biological parameters : ferritin (mg/l) | 2 YEARS | 
| Evolution of Biological parameters : chitotriosidase (nmol/h/ml) | To describe the evolution of biological parameters : chitotriosidase (nmol/h/ml) | 2 YEARS | 
| Evolution of Biological parameters : CCL18 (ng/ml) | To describe the evolution of biological parameters : CCL18 (ng/ml) | 2 YEARS | 
| Evolution of Biological parameters : vitamin D (nmol/L) | To describe the evolution of biological parameters : vitamin D (nmol/L) | 2 YEARS | 
| Evolution of Biological parameters : vitamin B12 (pmol/l) | To describe the evolution of biological parameters : vitamin B12 (pmol/l) | 2 YEARS | 
| Evolution of Biological parameters : serum glutamate oxaloacetate transaminase (SGOT) (U/l) | To describe the evolution of biological parameters : SGOT (U/l) | 2 YEARS | 
| Evolution of Biological parameters : Aspartate aminotransferase (AST) (U/l) | To describe the evolution of biological parameters : AST (U/l) | 2 YEARS | 
| Evolution of Biological parameters : serum glutamate pyruvate transaminase (SGPT) (U/l) | To describe the evolution of biological parameters : SGPT (U/l) | 2 YEARS | 
| Evolution of Biological parameters : Alanine Aminotransferase (ALT) (U/l) | To describe the evolution of biological parameters : ALT (U/l) | 2 YEARS | 
| Evolution of Biological parameters : Gamma-glutamyltransferase (GGT) (U/l) | To describe the evolution of biological parameters : GGT (U/l) | 2 YEARS | 
| Evolution of Biological parameters : alkaline phosphatase (U/l) | To describe the evolution of biological parameters : alkaline phosphatase (U/l) | 2 YEARS | 
| Evolution of Biological parameters : triglycerides (mmol/l) | To describe the evolution of biological parameters : triglycerides (mmol/l) | 2 YEARS | 
| Evolution of Biological parameters : total cholesterol (mmol/l) | To describe the evolution of biological parameters : total cholesterol (mmol/l) | 2 YEARS | 
| Evolution of Biological parameters : gamma globulin (g/l) | To describe the evolution of biological parameters : gamma globulin (g/l). | 2 YEARS | 
| Evolution of Biological parameters : serum calcium (mmol/l) | To describe the evolution of biological parameters : serum calcium (mmol/l) | 2 YEARS | 
| Evolution of Biological parameters : presence or absence of a monoclonal peak and the type if any. | To describe the evolution of biological parameters : presence or absence of a monoclonal peak and the type if any. | 2 YEARS |