Minimal Flow Application in One Lung Ventilation

Study Overview
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Brief Summary
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Interest in low fresh gas flow anesthesia has increased in recent years. The high standard of anesthesia machines, the presence of monitors that continuously and thoroughly analyze the anesthetic gas composition, and the increased knowledge of the pharmacodynamics and pharmacokinetics of inhalation anesthetics greatly facilitated the safe administration of low-flow anesthesia.Low-flow anesthesia can be mentioned for most patients if modern re-breathing systems are used but only if the fresh gas flow rate is reduced below 2 lt / min. In 1974, Virtue was defined as a technique called minimal flow, in which the fresh gas flow was not exceeded 0.5 lt / min. Although there are too many applications for low current in the literature, there is little literature for use in one lung.

Detailed Description
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Our research is planned prospectively. During the preoperative examination, patients will be informed about the study and their written consent will be obtained. On the morning of the operation, anesthesia gas monitor calibration and leak test will be started with automatic tests of the anesthesia device (Drager-Perseus A500).The leak test for the ventilator and breathing circuit for the patient will be repeated in all operations. The carbon dioxide trap will be evaluated in terms of its dryness and color and will be replaced at appropriate times. The patients who were taken to the operation table were venously opened with a 20-gauge cannula from the back of the hand, and perfusion of 10 ml / kg / h 0.9% sodium chloride was started. ECG, SPO2, NIBP monitoring (Siemens SC-7700), starting before anesthesia (basal), after induction, after intubation 1.min and 5., 10., 15., 20., 25., 30., 40 ., 50th, 60th, 75th, 90th, 105th, 120th minutes and preoperative arterial blood gas (AKG) will be taken.1μg / kg fentanyl (Fentanyl Citrate, Abbott Lab. North Chicago, USA), 5-7 mg / kg thiopental (Pental) for anesthesia induction after preoxygenation in 100% O2 and fresh gas flow 4L / min with spontaneous breathing for 3 minutes with mask sodium, IE Ulagay, Istanbul, Turkey) and 0.1 mg / kg vecuronium (Norcuro, Organon, Oss. the Netherlands) was administered iv. When muscle relaxation was observed, orotracheal intubation was performed and the patient (Dräger Perseus) was adjusted with an anesthesia device to have a tidal volume of 7-10 ml / kg, respiratory frequency 12 / min, and the ratio of I: E 1: 2. The tube was placed by selective intubation with the help of fiberoptic bronchoscopy. MAC values will be kept between 4-6%. Alarm limits FiO2 30% lower limit, desflurane 10% vol upper limit, EtCO2 45mmhg upper limit Paw 5cmh20 six lower limit, 30cmh2o upper limit set. co2 absorbent, as sodalime (Sorbo-lime, Berk, Turkey) were used. Arterial Blood Gas (ABG) analysis will be performed at zero and then half hour intervals of single lung ventilation. Special attention will be paid not to open the system. Muscle relaxant antagonism will be achieved in all patients with 0.01mg / kg of atropine and 0.03mg / kg of neostigmine. At the end of the operation, the recovery period characteristics of all patients at the 1st, 5th, and 10th minutes before and after extubation were evaluated with Aldrete Kraulik's post-anesthesia evaluation system. Gas consumption amounts will be monitored on the monitor and recorded.

Official Title
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The Effects of Minimal Flow Anesthesia on Hemodynamic Parameters, Compilation and Gas Consumption in Single Lung Ventilation

Conditions
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Ventilator Lung, Anesthesia; Functional

Intervention / Treatment
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* Procedure: minimal flow anesthesia


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ASA 1-3 Patients Single lung ventilation during the operation Age>18 Exclusion Criteria: Age<18 ASA 4 pregnancy COPD patients

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Interventional Model Description: prospectice randomized
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: minimal flow anesthesia<br>the patiennts who have thoracic sugery with one lung ventilaiton | Procedure: minimal flow anesthesia<br>* Investigators will use minimal flow anesthesia (0,5 lt/min) during surgery with one lung ventilation<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Age | Years | during surgery | 
| Gender | Male/Female | during surgery | 
| ASA : | I, II, III, IV | during surgery | 
| Height: | centimeter | during surgery | 
| Weight | kilogram | during surgery | 
| BMI: | kg/m2 | during surgery | 
| Side of surgery | left /right | during surgery | 
| Side of double lumen tube | left/right | during surgery | 
| Desfluran consumption | ml | during surgery | 
| Heart Rate | beats /minute | during surgery | 
| SpO2 | percent | during surgery | 
| Systolic Blood Pressure | mmHg/min | during surgery | 
| Diastolic Blood Pressure | mmHg/min | during surgery | 
| Respiratory Rate | frequency/ min | during surgery | 
| Intubation tube size | french | during surgery | 
| duration of anesthesia | minutes | during surgery | 
| Duration of single lung ventilation | minutes | during surgery | 
| Operation time | minutes | during surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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one lung ventilation, low flow anesthesia, gas consumption