Sebum Collection and Skin Barrier Function Analysis

Study Overview
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Brief Summary
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The goal is this study is to evaluate how the skin surface lipid composition is correlated with overall sebum production, barrier function, and inflammatory disease status. We hypothesize that there will be differences in the skin surface composition among subjects of various groups: Young vs older healthy population Atopic dermatitis vs Acne vs Healthy controls Active smokers vs non-smoker controls

Detailed Description
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This study will be conducted through the use of painless tapes to collect lipid. These will be applied to the skin and removed. Secondly, the barrier function will be evaluated through the use of non-invasive painless devices that measure sebum, skin water loss, and skin hydration.

Official Title
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Sebum Collection for Analysis and Correlation to Sebum Production, Barrier Function, and With Cutaneous and Internal Inflammatory Disease

Conditions
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Smoking, Acne, Atopic Dermatitis, Aging

Intervention / Treatment
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* Other: Skin Surface Lipid Collection and Skin Barrier Function


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Subjects that are 12 years of age or older Exclusion Criteria: None

Ages Eligible for Study
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Minimum Age: 12 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Young Age - Healthy<br>These subjects are between the age of 12 and 35 years. This group will undergo the following intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices. | Other: Skin Surface Lipid Collection and Skin Barrier Function<br>* All five groups will undergo the same study intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.<br>* Other names: skin hydration;|
| Old Age -Healthy<br>These subjects are 55 years of age and older. This group will undergo the following intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices. | Other: Skin Surface Lipid Collection and Skin Barrier Function<br>* All five groups will undergo the same study intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.<br>* Other names: skin hydration;|
| Active Smoker<br>These subjects are active smokers who smoke often. This group will undergo the following intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices. | Other: Skin Surface Lipid Collection and Skin Barrier Function<br>* All five groups will undergo the same study intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.<br>* Other names: skin hydration;|
| Dermatological skin condition: Acne vulgaris<br>These subjects have acne vulgaris. This group will undergo the following intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices. | Other: Skin Surface Lipid Collection and Skin Barrier Function<br>* All five groups will undergo the same study intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.<br>* Other names: skin hydration;|
| Dermatological skin condition: Atopic dermatitis<br>These subjects have atopic dermatitis. This group will undergo the following intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices. | Other: Skin Surface Lipid Collection and Skin Barrier Function<br>* All five groups will undergo the same study intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.<br>* Other names: skin hydration;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Lipid Profile-aging | The lipid profile of the subject group will be evaluated through the use of painless tapes that will be applied to the skin. | 1 day | 
| Lipid Profile-acne | The lipid profile of the subject group will be evaluated through the use of painless tapes that will be applied to the skin. | 1 day | 
| Lipid Profile-atopic dermatitis | The lipid profile of the subject group will be evaluated through the use of painless tapes that will be applied to the skin. | 1 day | 
| Lipid Profile-smoking | The lipid profile of the subject group will be evaluated through the use of painless tapes that will be applied to the skin. | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Skin Barrier Function- aging | The skin barrier function will be evaluated for this group through the use of non-invasive handheld devices. These devices provide information about sebum secretion rate, skin water loss, and skin hydration. | 1 day | 
| Skin Barrier Function- acne | The skin barrier function will be evaluated for this group through the use of non-invasive handheld devices. These devices provide information about sebum secretion rate, skin water loss, and skin hydration. | 1 day | 
| Skin Barrier Function- atopic dermatitis | The skin barrier function will be evaluated for this group through the use of non-invasive handheld devices. These devices provide information about sebum secretion rate, skin water loss, and skin hydration. | 1 day | 
| Skin Barrier Function- smoking | The skin barrier function will be evaluated for this group through the use of non-invasive handheld devices. These devices provide information about sebum secretion rate, skin water loss, and skin hydration. | 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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acne, younger age, older age, atopic dermatitis, smoker