Autogenous Bone Mixed With Xenograft Versus Xenograft Alone Versus Absorbent Gelatin Sponge

Study Overview
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Brief Summary
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Alveolar bone atrophy post-extraction has been well documented in the past years. normal healing event results in a minimal loss of vertical height (around 1 mm), but a substantial loss of width in the buccal-lingual plane (4-6 mm). Alveolar socket preservation is thought to deal with this issue as to prevent the loss of alveolar bone dimensions post extraction in the case of delayed implant placement

Official Title
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Alveolar Ridge Preservation in Mandibular Molars Using Mixture of Autogenous Bone & Anorganic Bovine Bone (ABB) Versus Anorganic Bovine Bone Alone Versus Absorbent Gelatin Sponge

Conditions
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Bone Resorption, Alveolar Bone Loss, Alveolar Bone Resorption, Bone Graft Failure

Intervention / Treatment
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* Procedure: Mixture of Autogenous bone & Anorganic Bovine Bone (ABB)
* Procedure: Anorganic Bovine Bone (ABB)
* Procedure: Absorbable gelatin sponge


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adult patients with hopeless mandibular molars indicated for extraction and implant placement in two stages that indicate socket preservation. Both sexes. No intraoral soft and hard tissue pathology. No systemic condition that contraindicate implant placement. Exclusion Criteria: Presence of fenestrations or dehiscence of the residual bony Walls after extraction. Heavy smokers more than 20 cigarettes per day .(24) Patients with systemic disease that may affect normal healing. Psychiatric problems Disorders to implant are related to a history of radiation therapy to the head and neck neoplasia, or bone augmentation to implant site. Patients that refuse to be called back for implant placement post extraction. Patients that have exceeded bone resorption surrounding the tooth prior to extraction and require guided bone regeneration. Pregnant Females.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Mixture of Autogenous bone & Anorganic Bovine Bone (ABB)<br>socket preservation with a mixture of autogenous bone graft acquired at the time of extraction mixed with a 50:50 ratio of Anorganic bovine bone | Procedure: Mixture of Autogenous bone & Anorganic Bovine Bone (ABB)<br>* Filling the socket with Mixing of autogenous bone graft and anorganic bovine bone in a 50:50 ratio<br>|
| Active Comparator: Anorganic bovine bone graft (ABB)<br>filling the extraction socket with ABB graft | Procedure: Anorganic Bovine Bone (ABB)<br>* Filling the socket with Anorganic bovine bone graft material only<br>|
| Active Comparator: Absorbable gelatin Sponge<br>Filling the socket with an absorbable gelatin sponge | Procedure: Absorbable gelatin sponge<br>* Filling the socket with an absorbable gelatin sponge foam pack<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Histomorphometrical bone analysis | histological bone core analysis | 6 month post primary surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Alveolar Bone marginal loss | CBCT measurements of marginal bone dimensional difference | 6 month post primary surgery |