Role of Dopamine on Loss Aversion Behaviour: Study on Parkinsonian Patients

Study Overview
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Brief Summary
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Use lay language. Many decisions involve the possibility of gaining or losing relative to the status quo. The loss aversion behaviour is a cognitive concept explaining that people are more sensitive to the possibility of losing objects or money than they are to the possibility of gaining the same objects or amounts of money. We hypothesised that dopamine could be involved in the loss aversion behaviour. To highlight this, we have chosen a model of dopaminergic depletion : the Parkinson's disease The primary purpose of this protocol is to study the role of dopamine in the loss aversion phenomenon by comparing brain activity in parkinsonian patient with and without treatment with L Dopa, when they are exposed to mixed (gain/loss) gambles using money. The second purpose is to highlight the role of a dopamine depletion by comparing patient without treatment vs healthy paired control. 2 groups : 20 parkinsonian patients (tested two times : with and without treatment by L dopa) 20 healthy paired control Description of the protocol for patients : J0 : Inclusion visit (duration : 4h): motor assessment (UPDRS) neuropsychological and psychiatric assessment (MMS, MATTIS, BREF, Stroop, Ardouin scale, UPPS, MADRS, Hamilton, LARS). J0+1 day and J0 +2 days : 2 visits of MRI (magnetic resonance imaging) acquisition (with or without treatment) : Each acquisition was composed by an orientation sequence+ an anatomic sequence + a functional sequence. For healthy subjects, they have only one visit of 2 hours including a MMS, a MADRS and the MRI acquisitions.

Detailed Description
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Use lay language. Many decisions involve the possibility of gaining or losing relative to the status quo. The loss aversion behaviour is a cognitive concept explaining that people are more sensitive to the possibility of losing objects or money than they are to the possibility of gaining the same objects or amounts of money. We hypothesised that dopamine could be involved in the loss aversion behaviour. To highlight this, we have chosen a model of dopaminergic depletion : the Parkinson's disease The primary purpose of this protocol is to study the role of dopamine in the loss aversion phenomenon by comparing brain activity in parkinsonian patient with and without treatment with L Dopa, when they are exposed to mixed (gain/loss) gambles using money. The second purpose is to highlight the role of a dopamine depletion by comparing patient without treatment vs healthy paired control. 2 groups : 20 parkinsonian patients (tested two times : with and without treatment by L dopa) 20 healthy paired control Description of the protocol for patients : J0 : Inclusion visit (duration : 4h): motor assessment (UPDRS) neuropsychological and psychiatric assessment (MMS, MATTIS, BREF, Stroop, Ardouin scale, UPPS, MADRS, Hamilton, LARS). J0+1 day and J0 +2 days : 2 visits of MRI (magnetic resonance imaging) acquisition (with or without treatment) : Each acquisition was composed by an orientation sequence+ an anatomic sequence + a functional sequence. For healthy subjects, they have only one visit of 2 hours including a MMS, a MADRS and the MRI acquisitions.

Official Title
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Role of Dopamine on Loss Aversion Behaviour: Study on Parkinsonian Patients.

Conditions
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Parkinson's Disease

Intervention / Treatment
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* Behavioral: Role of dopamine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients : Men or women aged between 35 -75 years Patients with an idiopathic Parkinson's disease according to UKPDSBB criterias with a disease evolution duration : 5-10 years) With fluctuations in end of doses + morning akinesia. Non dement (MMS>24 ; Mattis > 130) Affiliated to National Health system Having given their informed consent Healthy controls Men or women aged between 35 to 75 years Non dement (MMS>24 ) Affiliated to National Health system Having given their informed consent Exclusion Criteria: Patients : Patients suffering of an atypical Parkinson syndrome Psychiatric pathology Tremor form (≥ 3 (item tremor of UPDRS)) Patients with Impulsive control disorders Depression, dementia Pregnant Under guardianship In excluding period for another study Any contra-indication to MRI Healthy subject Subject with neurological, psychiatric diseases Depression, dementia Pregnant Under guardianship In excluding period for another study Any contra-indication to MRI

Ages Eligible for Study
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Minimum Age: 35 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: patients with and without treatment by L dopa)<br>to study the role of dopamine in the loss aversion phenomenon by comparing brain activity in parkinsonian patient with and without treatment with L Dopa, when they are exposed to mixed (gain/loss) gambles using money. | Behavioral: Role of dopamine<br> <br> |
| Other: healthy paired control<br>to highlight the role of a dopamine depletion by comparing patient without treatment vs healthy paired control. | Behavioral: Role of dopamine<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| percentage of signal modification |  | From day 1 (without L Dopa) to day 2 (with L Dopa) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cluster activation size |  | from day 1 (without L Dopa) to day 2 (with LDopa) | 
| Brain activity indicators |  | from day 1 (without L Dopa) to day 2 (with L Dopa) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Loss aversion, Dopamine, Parkinson's disease