Outcome of Specific IgE Level in Children With IgE-mediated Wheat Allergy After Stop Using Wheat Containing Skin Care

Study Overview
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Brief Summary
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Wheat allergy is increasing in Thailand. Some studies show that cutaneous exposure of allergen may cause allergy and there are many wheat containing skin care products that are over-the-counter. So the purpose of our study is to determine level of specific immunoglobulin E antibodies to wheat and omega-5 gliadin in wheat allergy patients after stop using wheat containing skin care products.

Detailed Description
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All children in this study were sensitized to wheat. Each patient was clinically evaluated, with focus on wheat allergy by medical history, medical examination included skin status (suspected atopic dermatitis or not). Blood sample was taken for baseline determination of immunoglobulin E antibodies to wheat and to omega-5 gliadin. Transepidermal water loss was examined in case with atopic dermatitis. The primary outcome was the specific immunoglobulin E antibodies to wheat and omega-5 gliadin in case that stop using wheat containing skin care product and case that continue using products.

Official Title
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Outcome of Specific IgE Level in Children With IgE-mediated Wheat Allergy After Stop Using Wheat Containing Skin Care

Conditions
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Wheat Allergy, Children

Intervention / Treatment
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* Other: wheat containing skin care products


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: children age 1 to 18 years History of IgE-mediated wheat allergy Exclusion Criteria: Parents refused to sign the consent severe atopic dermatitis on oral immunothery severe IgE mediated reaction after using wheat containing skin care product

Ages Eligible for Study
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Minimum Age: 1 Year
Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Atopic dermatitis with stop using product<br>case wheat allergy with atopic dermatitis and stop using wheat containing skin care products | Other: wheat containing skin care products<br>* stop or continue using wheat containing skin care products<br>|
| Experimental: Atopic dermatitis with containing using product<br>case wheat allergy with atopic dermatitis and continue using wheat containing skin care products | Other: wheat containing skin care products<br>* stop or continue using wheat containing skin care products<br>|
| Experimental: Non atopic dermatitis with stop using product<br>case wheat allergy with normal skin and stop using wheat containing skin care products | Other: wheat containing skin care products<br>* stop or continue using wheat containing skin care products<br>|
| Experimental: Non atopic dermatitis with continue using product<br>case wheat allergy with normal skin and continue using wheat containing skin care products | Other: wheat containing skin care products<br>* stop or continue using wheat containing skin care products<br>|
| No Intervention: Atopic dermatitis with no product use<br>case wheat allergy who does not use wheat containing skin care products and has atopic dermatitis | |
| No Intervention: Non atopic dermatitis with no product use<br>case wheat allergy who does not use wheat containing skin care products and no atopic dermatitis | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Specific IgE to wheat and omega-5 gliadin level | To follow-up the level of wheat and omega5 gliadin specificIgE after stop using the wheat containing skin care product compare to patients who continue using the product. | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| level of transepidermal water loss | To follow up the transepidermal water loss in patients with atopic dermatitis, comparing the group that continue using the product to the group that stop using the product. | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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wheat allergy, skin sensitization, specific IgE, wheat containing skin care