The Effect of (L-PRF) Membrane in The Treatment of Gingival Recession

Study Overview
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Brief Summary
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evaluation of the use of L-PRF membrane with coronally repositioned flap in treatment of localized gingival recession (Class I & II) in comparison with the use of connective tissue graft

Detailed Description
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Twenty patients, who are candidates for gingival recession coverage, will participate in this prospective clinical trial. Group 1(10 patients) : Coronally repositioned flap will be done and L PRF membrane will be placed into the tissues Group 2 (Control group)(10 patients) : Coronally repositioned flap will be done with sub epithelial connective tissue Parameters Clinical evaluation of percentage of root coverage and keratinized tissue width Esthetic outcome evaluation Will be done using the root coverage esthetic score (Cairo et al. 2009) that include Both evaluations will be done at 3, 6 and 9 months

Official Title
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The Effect of Leukocyte Platelet Rich Fibrin(L-PRF) Membrane in The Treatment of Localized Gingival Recession (Randomized Controlled Clinical Trial)

Conditions
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Localized Gingival Recession

Intervention / Treatment
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* Procedure: Leukocyte Platelet rich fibrin membrane


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Systemically free patients (American Society of Anesthesiologists I; ASA I). Age range (20 -40) years. Good compliance with the plaque control instructions following initial therapy. Patients diagnosed with Miller class I or II in anterior and premolar teeth Availability for follow up and maintenance program. Exclusion Criteria: Patient suffering from periodontitis Presence of smoking habit. Presence of occlusion interference. Pregnant and lactating females. Vulnerable group of patients (handicapped, mentally retarded and prisoners).

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Leukocyte Platelet Rich Fibrin<br>Leukocyte Platelet Rich Fibrin will be used | Procedure: Leukocyte Platelet rich fibrin membrane<br>* the use of Leukocyte Platelet rich fibrin as grafting materials for treatment of recession<br>* Other names: sub epithelial connective tissue;|
| Active Comparator: connective tissue<br>connective tissue will be used | Procedure: Leukocyte Platelet rich fibrin membrane<br>* the use of Leukocyte Platelet rich fibrin as grafting materials for treatment of recession<br>* Other names: sub epithelial connective tissue;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| recession treatment | 2-Esthetic outcome evaluation was done using Root coverage esthetic score (RES) system ( Cairo et al. 2009) the RES include the following parameters • Level of the gingival margin (GM):(minimum) Zero points = failure of root coverage (gingival margin apical or equal to the baseline recession); 3 points = partial root coverage;(maximum) 6 points = CRC. | 9 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| soft tissue thickness (Volumetric assessment) | Preoperatively a cast was made and scanned. At 9 months after surgical procedure the same procedure was done to determine the soft tissue thickness after the surgery. The difference between the tissue thickness before and after was used to determine the efficacy of the different surgical grafting materials used. | 9 months |