Effect of Fasting Versus Feeding on the Bone Metabolic Response to Running

Study Overview
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Brief Summary
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This study examined changes in bone metabolism (markers of bone turnover, calcium metabolism) with a bout of acute treadmill running preceded by either a single, mixed meal or an overnight fast.

Detailed Description
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Ten physically active males aged 28 ± 4 y (mean ± 1SD) completed two, counterbalanced, 8 d trials. After 3 d on a standardised diet, participants performed 60 min of treadmill running at 65% VO2max on Day 4 following an overnight fast (FAST) or a standardised breakfast (FED). Blood samples were collected at baseline, before exercise, during exercise, for 3h after exercise and on four consecutive follow-up days (FU1-FU4). Plasma/serum were analysed for β CTX, P1NP, OC, bone ALP, PTH, ACa, PO4, OPG, cortisol, leptin and ghrelin.

Official Title
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Effect of Fasting Versus Feeding on the Bone Metabolic Response to Running

Conditions
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Feeding Patterns, Bone Resorption

Intervention / Treatment
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* Other: Overnight fast


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: history of weight bearing exercise fasting vitamin D concentration of >30 nmol•L-1 and/or a fasting parathyroid hormone (PTH) concentration of <6.9 pmol•L-1. Exclusion Criteria: smokers suffered a bone fracture in the previous 12 months musculoskeletal injury condition/medication known to affect bone metabolism

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Fasting<br>Overnight fast | Other: Overnight fast<br>* Overnight fast from 21:00 h<br>* Other names: Fasting;|
| No Intervention: Feeding<br>Normal breakfast | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in C-terminal telopeptide region of collagen type 1 (B-CTX) concentration from baseline | B-CTX is a specific marker of bone resorption. It's circulating concentration is altered by both exercise and feeding | At 08:00 h (Baseline), 09:00 h, 09:30 h, and 10:15 h (Pre-exercise), after 30 and 60 min of exercise, after 1, 2, and 3 h of recovery and at 1, 2, 3 and 4 day post-exercise | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in parathyroid hormone (PTH) concentration from baseline | PTH is reported to induce both bone resorption and bone formation. It's circulating concentration is altered by both exercise and feeding. | At 08:00 h (Baseline), 09:00 h, 09:30 h, and 10:15 h (Pre-exercise), after 30 and 60 min of exercise, after 1, 2, and 3 h of recovery and at 1, 2, 3 and 4 day post-exercise | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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feeding patterns, aerobic exercise, osteoclasts