Neutrophil, Lymphocyte and Platelet as a Predictor for AKI and Mortality

Study Overview
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Brief Summary
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Cell-count related risk factors for acute kidney injury after cardiovascular surgery have been reported. The authors attempted to investigate whether the perioperative cell counts of neutrophil, lymphocyte, platelet are associated with the postoperative acute kidney injury and long-term mortality after cardiovascular surgery using cardiopulmonary bypass.

Detailed Description
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Acute kidney injury (AKI) after cardiovascular surgery remains a serious complication associated with increased mortality for up to 10 years. The incidence of AKI after cardiovascular surgery is as high as 55% and the incidence of renal replacement therapy (RRT) to be up to 8 %. Cell-count related risk factors for acute kidney injury after cardiovascular surgery have been reported. The authors attempted to investigate whether the perioperative cell counts of neutrophil, lymphocyte, platelet are associated with the postoperative acute kidney injury and long-term mortality after cardiovascular surgery using cardiopulmonary bypass.

Official Title
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Risk Factor of Acute Kidney Injury After Open Heart Surgery With Cardiopulmonary Bypass

Conditions
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Acute Kidney Injury

Intervention / Treatment
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* Procedure: Cardiovascular surgery with cardiopulmonary bypass


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adult patients who underwent cardiovascular surgeries with cardiopulmonary bypass (CPB), including valve replacement and surgery on the thoracic aorta at the Seoul National University Hospital between 2007 and 2015 Exclusion Criteria: Missing preoperative serum creatinine (sCr) values Missing preoperative platelet, neutrophil and lymphocyte counts Patients who underwent preoperative hemodialysis

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cardiovascular surgery with cardiopulmonary bypass<br>Cardiovascular surgery with cardiopulmonary bypass | Procedure: Cardiovascular surgery with cardiopulmonary bypass<br>* Patients who underwent cardiovascular surgery including valve replacement or thoracic aortic surgery with cardiopulmonary bypass<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Acute kidney injury | acute kidney injury during postoperative seven days defined by Kidney Disease Improving Global Outcomes (KDIGO) criteria | postoperative day seven | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| All-cause mortality | all-cause mortality after cardiovascular surgery after postoperative seven years | postoperative seven years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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acute kidney injury, cardiovascular surgery, mortality