Hyaluronic Acid Effect on Xenogenic Bone Healing

Study Overview
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Brief Summary
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The aim of this study is to test the hyaluronic acid hydrogel impact on the healing acceleration of xenogenic bone substitutes used in ridge preservation. Following tooth extraction, bone particles are mixed with the hyaluronic acid gel and grafted in the tooth socket. at the implant placement phase, a cone beam computer assisted tomography file is recorded in order to compare it with the baseline and a biopsy to evaluate the histological consequences.

Official Title
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Hyaluronic Acid Effect on Xenogenic Bone Substitutes Healing During Ridge Preservations: A Radiological and Histomorphometric Study

Conditions
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Bone Resorption, Tooth Loss

Intervention / Treatment
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* Procedure: Ridge preservation: Tooth extration and immediat bone grafting in the socket


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients in need of tooth extraction and willing to receive dental implants in the extraction site Presence of two mono radicular teeth in need of extraction Exclusion Criteria: Patients with systemic diseases Patients under 8 years and above 60 years. Presence of endodontic or periodontal lesion in the extraction sites

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Radiological assessement<br>Two CBCTs were recorded and compared, one at the baseline and the other at 4 months post-op. The bone resorption was quantified and analyzed using ITK-SNAP software | Procedure: Ridge preservation: Tooth extration and immediat bone grafting in the socket<br>* Following the tooth extraction, the socket is filled with a mixture of xenogenic bone and hyaluronic acid and sealed with an epithelio-connective arrested from the maxillary palate<br>|
| Experimental: Histomorphometric analysis<br>During implant placement (4 months after the bone grafting), a bone biopsy is collected and stained with several colorants to analyze the biological bone healing | Procedure: Ridge preservation: Tooth extration and immediat bone grafting in the socket<br>* Following the tooth extraction, the socket is filled with a mixture of xenogenic bone and hyaluronic acid and sealed with an epithelio-connective arrested from the maxillary palate<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Radiological assessement of the boe resorption | the baseline if the CBCT is compared to the 4 months post-op to assess the bone resorption | 4 months | 
| Histomorphometric analysis | During implant placement, a bone biopsy is harvested and stained with different colorants to assess microscopically the biological healing | 4 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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dental implant, tooth extraction, ridge preservation, hyaluronic acid