Treatment of Suicidal Women With Borderline Personality Disorder

Study Overview
=================
Brief Summary
-----------------
This study is a component analysis of dialectical behavior therapy (DBT) to determine the importance of DBT skills training and DBT individual therapy in treating suicidal women with borderline personality disorder.

Detailed Description
-----------------
People with borderline personality disorder have limited behavioral skills and react abnormally to emotional stimulation. Standard dialectical behavior therapy (SDBT) has been shown to be an effective treatment for borderline personality disorder. This treatment combines weekly group sessions, at which patients learn new ways of dealing with their emotions, with weekly individual sessions with a therapist to discuss their emotions. The study compares SDBT to both individual DBT with no skills training and DBT skills training with no individual therapy. The study will determine whether efficacy of standard DBT is reduced when either DBT skills training or individual DBT therapy is removed. Participants are randomly assigned to receive 1 year of SDBT, DBT with group sessions but no individual sessions, and DBT with individual sessions with no group sessions. Participants are monitored for 1 year after completing their assigned therapy. Throughout the 1-year study and during the 1-year follow-up period, self-report scales and questionnaires are used to assess participants every 4 months. These scales and questionnaires measure participants' suicidal thoughts and attempts, treatment compliance, emotional coping skills, social functioning, and overall well-being.

Official Title
-----------------
Assessment and Treatment of Parasuicidal Patients

Conditions
-----------------
Borderline Personality Disorder, Suicide

Intervention / Treatment
-----------------
* Behavioral: Standard dialectical behavior therapy (SDBT)
* Behavioral: Individual DBT with no DBT group sessions (DBT-I)
* Behavioral: Group Skills DBT with no DBT individual sessions (DBT-S)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosis of BPD At least one suicide attempt in the year prior to study entry AND at least one intentional self-injury within the 8 weeks prior to study entry Willing and able to comply with all study requirements Exclusion Criteria: IQ less than 70 Life-threatening anorexia Street homelessness with no contact information Admittance to a hospital with no expectation of discharge within 3 weeks prior to study entry OR sentenced to a jail or prison term that will last for more than 3 weeks Ordered by the court to receive psychological treatment Meet DSM-IV criteria for schizophrenia, bipolar disorder, or seizure disorder Medical conditions other than BPD that may interfere with the study

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: S-DBT<br>Participants receive standard dialectical behavior therapy | Behavioral: Standard dialectical behavior therapy (SDBT)<br>* Standard DBT includes: 1) individual DBT therapy (1 hour per week), 2) DBT group skills training (2.5 hours per week), 3) telephone consultation (as needed), and 4) therapist consultation team (1 hour per week).<br>* Other names: DBT, SDBT;|
| Active Comparator: DBT-I<br>Participants receive individual dialectical behavior therapy plus activities group | Behavioral: Individual DBT with no DBT group sessions (DBT-I)<br>* Individual DBT (DBT-I) is 1 hour per week of individual therapy and 2.5 hours per week with the psychosocial activities group.<br>* Other names: DBT, DBT-I;|
| Active Comparator: DBT-S<br>Participants receive dialectical behavior therapy group skills plus case management | Behavioral: Group Skills DBT with no DBT individual sessions (DBT-S)<br>* DBT group skills training is 2.5 hours per week and includes individual case management.<br>* Other names: DBT, DBT-S;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Suicidal thoughts or attempts |  | Measured at Year 2 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Coping skills |  | Measured at Year 2 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Suicide, Women, Emotions, Psychotherapy, Group