Mobile-based Games for Cognitive Training in Children With Neurodevelopmental Disorders

Study Overview
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Brief Summary
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Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with characteristic deficits in social functioning and presence of stereotypic behavior. Several research studies have examined potential deficits in cognitive skills, such as working memory, in this condition. A meta-analysis of the studies aimed at evaluating working memory (WM) in autistic population suggested deficits in visual and verbal aspects of WM. Working memory training has also been studied in other neurodevelopmental disorders such as Attention Deficit Hyperactivity Disorder (ADHD). The study includes development of mobile-based games for training WM and other cognitive skills in patients and the evaluation of such training in reducing symptoms of ASD. These games may also be useful for other neurodevelopmental disorders.

Official Title
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Mobile-based Games for Cognitive Training in Children With Neurodevelopmental Disorders

Conditions
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Autism Spectrum Disorder

Intervention / Treatment
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* Behavioral: Game-based cognitive training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosis of Autism Spectrum Disorder or another related neurodevelopmental disorder with symptoms of ASD Exclusion Criteria: Inability to use smartphones/tablets Serious intellectual disabilities. Sensory impairment

Ages Eligible for Study
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Minimum Age: 5 Years
Maximum Age: 16 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Game-based training<br>Participants play games for cognitive training | Behavioral: Game-based cognitive training<br>* A suite of 5 games is presented to the participants for training working memory<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Corsi Task Block Span | It is an indicator of working memory. The value ranges between 0 and 9. Higher values mean better outcome. | change from baseline to program completion or last usage (up to 30 days of usage within 56-day trial period from the first day of data collection) | 
| Corsi Task Total Score | It is an indicator of working memory. The minimum value is 0, the maximum value has no limit. Higher values mean better outcome. | change from baseline to program completion or last usage (up to 30 days of usage within 56-day trial period from the first day of data collection) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Autism Treatment Evaluation Checklist Total Score | Autism Treatment Evaluation Checklist is a measure to evaluate treatments for Autism. The total score ranges between 0 and 179. Higher values mean better outcome. | change from baseline to program completion or last usage (up to 30 days of usage within 56-day trial period from the first day of data collection) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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digital intervention, serious games