Structural and Molecular Neuroplasticity in Migraine

Study Overview
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Brief Summary
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The main purpose of this study is to integrate novel MRI techniques with positron emission tomography(PET) for the study of structural and molecular neuroplasticity in the brain of migraineurs, and its clinical association with changes in pain perception and modulation (e.g. allodynia). We will attempt to acquire images of the brain that may, in the future, assist doctors in better understanding how pain is felt and regulated in migraine sufferers.

Detailed Description
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To investigate interictal opioid receptor (MOR) binding potential (BPND) changes in migraineurs as compared to age/gender-matched healthy controls. To demonstrate that frequency of the headache attacks and severity of cutaneous allodynia levels in migraineurs experienced over multiple attacks are correlated with levels of MOR BPND in specific brain regions. To investigate whether dysfunction of the pain regulatory endogenous opioid system of migraineurs is correlated with changes in the gray matter thickness in cortical areas associated with pain perception and modulation.

Official Title
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Structural and Molecular Neuroplasticity in Migraine

Conditions
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Migraine

Intervention / Treatment
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* Procedure: Pet Scan
* Procedure: MRI scan
* Procedure: Quantitative Sensory Testing (QST)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Between 18-45 years of age Between 1-14 migraine attacks per month or healthy Exclusion Criteria: Cannot be taking daily migraine medication Healthy subjects cannot be taking hormonal birth control pills or other medication Cannot have chronic pain or a neurologic/psychiatric disorder such as: multiple sclerosis and bipolar disorder.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Migraine<br>20 subjects experiencing 1-14 migraines per month will undergo the following: Blood and urine samples will be collected Complete a series of questionnaires; some of which will be completed daily Quantitative Sensory Test (QST)will be performed Magnetic Resonance Imaging (MRI) PET imaging (during and outside of a migraine attack) | Procedure: Pet Scan<br>* Subjects will undergo Pet Scanning for 90 minutes<br>Procedure: MRI scan<br> <br> Procedure: Quantitative Sensory Testing (QST)<br> <br> |
| Active Comparator: Healthy<br>20 healthy subjects will undergo the following: Blood and urine samples will be collected Complete a series of questionnaires; some of which will be completed daily Quantitative Sensory Test (QST)will be performed Magnetic Resonance Imaging (MRI) PET imaging | Procedure: Pet Scan<br>* Subjects will undergo Pet Scanning for 90 minutes<br>Procedure: MRI scan<br> <br> Procedure: Quantitative Sensory Testing (QST)<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Level of mu-opioid receptor binding potential in the brain of episodic migraineurs during and outside the headache attack and compared to healthy controls. |  | 90 min PET scan | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation of migraine attack severity in migraineurs with mu-opioid receptor binding potential |  | 90 min PET scan | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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migraine