Computer Modelling of the Cervical Spine Movements in Cervical Dystonia

Study Overview
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Brief Summary
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Cervical dystonia (CD) is a syndrome characterized by sustained and/or phasic involuntary neck muscle activity causing abnormal head postures and movements. It is the most frequent form of adult focal dystonia. The distribution of dystonic muscles is unique for each patient, explaining the variety of patterns encountered. The therapeutic management of CD is essentially local and symptomatic: Botulinum Neurotoxin injections and/or specific retraining therapy programmes. Therefore, analyzing the characteristics of abnormal head movements and identifying the dystonic muscles are the key points of these treatments. To a better understanding of the posture and movement disorders of head and neck, we wish to establish a three-dimensional (3-D) computer model of cervical spine movements of ten healthy subjects built from images obtained with the Cone Beam  system. Then we will compare the cervical posture and movements for each of ten CD patients matched in age and genre to the computer model. Comparison with patients' images in the axial plane reconstructed by computer with the 3-D computer model will lead to the description of various patterns of CD. Analysis of the musculoskeletal disturbances in CD should be a help to improve the localization of Botulinum Neurotoxin injection sites as well as retraining programmes.

Conditions
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Cervical Dystonia, Primary

Intervention / Treatment
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* Device: cone beam imagery of cervical spine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Tonic form of focal or segmental cervical dystonia (diagnostic confirmed by a neurologist specialized in movement disorders) for CD patients, or absence of CD for control subjects absence of treatment by botulinum neurotoxin, or last injection > 3 months age > 18 and < 71 years informed consent medical insurance coverage Exclusion Criteria: CD mobile (clonic) and/or head tremor patient unable to sit without moving the head during the examination (x-ray pictures with cone beam) Other neurological disease with effect on the posture and/or movement of the cervical region Pain or traumatism of the cervical region requiring medical or surgical treatment in the preceding 6 months Pregnant or breast feeding patient Participation in another research with a potential impact on evaluation criteria patient under judiciary protection

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| CD patients<br>10 patients with a cervical dystonia | Device: cone beam imagery of cervical spine<br> <br> |
| control subjects<br>10 healthy patients | Device: cone beam imagery of cervical spine<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| comparison of bone marks positions (degrees) in patients ans control motions | positions measured in degrees with computerized imaging | baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cervical spine, Musculoskeletal imagery, computer modelling of cervical spine, ConeBeam.