Acute Vascular Response To Meals Varying In Glycemic Index And Glycemic Load

Study Overview
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Brief Summary
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This study examines the effects of carbohydrate type (high- or low-Glycemic Index (GI)) and amount (high- or low-Glycemic Load (GL)) have on blood glucose levels, blood pressure and arterial stiffness in healthy individuals. It will also determine whether subjective ratings such as test meal palatability and hunger are related to changes in blood glucose. The investigators hypothesize that: (1) High-GI meals, regardless of GL, will increase arterial stiffness; low-GI meals, regardless of GL, will have a neutral or lowering effect on arterial stiffness (augmentation index). (2) High-GI meals, regardless of GL, will have an elevating effect on both central and peripheral blood pressures. (3) The incremental area under the curve for blood glucose will show most significant differences between high-GI, high-GL and low-GI, low-GL meals at 30 and 90 min.

Official Title
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Variability of Acute Response to Equicaloric Test Meals Varying in Glycemic Index and Glycemic Load on Postprandial Glycemia, Arterial Stiffness and Blood Pressure in Healthy Adults

Conditions
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Healthy

Intervention / Treatment
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* Other: Boiled Pasta
* Other: Boiled Chickpeas with Oil
* Other: Instant Mashed Potatoes
* Other: Instant Mashed Potatoes with Egg Whites


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: healthy age 18 - 75 years BMI 18 - 25 kg/m2 brachial systolic blood pressure < 140 mmHg brachial diastolic blood pressure < 90 mmHg Exclusion Criteria: primary hypertension diabetes allergy or sensitivity to any foods to be used in the study gastrointestinal disorders chronic kidney disease liver disease hepatitis estrogen-sensitive cancer heavy alcohol use sleep apnea bleeding disorders planned surgery (within time frame of study) angina Congestive Heart Failure coronary revascularization peripheral vascular disease and/or coronary/cerebrovascular events within the previous 6 months positive HIV diagnosis prescription of anti-depressants, anti-hypertensives, anti-coagulant medications, diuretics, sympathomimetics, herbal therapies, vitamin or K supplementation, medication affecting NO synthesis chronic use or prescription of NSAIDs women of childbearing potential must not be pregnant or breastfeeding

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Low-GI, High-GL Meal<br>Boiled Pasta | Other: Boiled Pasta<br> <br> * Other names: Italpasta Fusilli;|
| Experimental: Low-GI, High GL Meal<br>Boiled Chickpeas with Oil | Other: Boiled Chickpeas with Oil<br> <br> * Other names: Irresistibles Life Smart Chick Peas;|
| Experimental: High-GI, High-GL Meal<br>Instant Mashed Potatoes | Other: Instant Mashed Potatoes<br> <br> * Other names: Betty Crocker Mashed Potatoes Homestyle;|
| Experimental: High-GI, Low-GL Meal<br>Instant Mashed Potatoes with Egg Whites | Other: Instant Mashed Potatoes with Egg Whites<br> <br> * Other names: Naturegg Simply Egg Whites 100% Pure Liquid Egg Whites;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To measure postprandial changes in augmentation index (AIx) to determine the acute effect of high- and low-GI and high- and low-GL meals on arterial stiffness. |  | 4 separate mornings, measurements taken at baseline and at 60, 120, 180 and 240 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To determine the acute effect of high- and low-GI and high- and low- GL meals on central and peripheral blood pressure |  | 4 separate mornings, measurements taken at baseline, 60, 120, 180 and 240 minutes. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Healthy, Glycemic Index, Glycemic Load, Blood Glucose, Arterial Stiffness