Effects of Knee-extensor Exercise Training in Chronic Obstructive Pulmonary Disease (COPD) Patients

Study Overview
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Brief Summary
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COPD patients have a reduced exercise tolerance due to a ventilatory limitation. Several studies have shown altered skeletal muscle function. The investigator will study the physiological response to knee-extensor exercise in COPD patients.

Detailed Description
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Reduced exercise tolerance is one of the hallmarks of COPD. The principal causes for exercise intolerance are ventilatory limitation leading to deconditioning and inactivity. However the weak correlation between exercise capacity and FEV1 implies that other factors than reduced pulmonary function contribute to this impairment as well. Several studies have found changes in skeletal muscle, with fibre shift, increased oxidative stress, increased inflammatory cytokines and impaired mitochondrial function, suggesting a lower limb dysfunction. Numerous exercise studies in COPD patients have shown physiological and physiological benefits of training and endurance training is now regarded as an important part in pulmonary rehabilitation. In this study we investigate training effects in patients with moderate to severe COPD with special focus on skeletal muscle. COPD patients will perform high intensity aerobic interval knee-extensor exercise training 3 days/week for six weeks . At baseline and follow-up, muscle oxygen consumption and mitochondrial respiration will be measured.

Official Title
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Effects of Knee-extensor Exercise Training in Chronic Obstructive Pulmonary Disease (COPD) Patients

Conditions
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Chronic Obstructive Pulmonary Disease

Intervention / Treatment
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* Behavioral: High intensity knee-extensor training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: COPD diagnosis with FEV1<70% exp, FEV1%FVC <70 % Age> 50 years Exclusion Criteria: Heart failure Symptomatic coronary artery disease Cancer Alcohol and drug abuse Severe mental illness Lower respiratory illness Participation in exercise- or lung rehabilitation program last 3 months pregnancy oral steroid use

Ages Eligible for Study
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Minimum Age: 50 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Knee extensor exercise training<br>High intensity aerobic knee-extensor exercise training | Behavioral: High intensity knee-extensor training<br>* High intensity aerobic knee-extensor exercise training, 4x 3 minutes interval training at < 90 % of peak power, 3 days/week for 6 weeks<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Peak power |  | At inclusion and after 6 weeks of training | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mitochondrial respiration, Vmax |  | At inclusion and after 6 weeks of training | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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exercise, Knee extensor