Attentional Bias Modification Treatment in OCD

Study Overview
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Brief Summary
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Obsessive-compulsive disorder is a chronic condition. Even with proper treatment, no significant improvement is reached in about 30% to 40% of patients. Thus, the development of new treatment strategies is necessary. The attentional bias - ability to aversive stimuli in capturing the attention of an individual compared to a neutral stimulus - has been extensively studied. Already training attentional bias modification has been shown effective in reducing anxiety present in other anxiety disorders.This project aims to: 1 - generate knowledge on attentional bias in individuals with OCD through the use of a standardized protocol developed for OCD; 2 - available to the scientific community the first specific paradigm for the study of attentional bias in OCD patients, 3 - test the effectiveness of a training protocol for reversing attentional bias in individuals with OCD.

Official Title
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Attentional Bias and Attentional Bias Modification Treatment in Obsessive-compulsive Disorder

Conditions
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Obsessive-compulsive Disorder

Intervention / Treatment
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* Behavioral: attentional bias modification treatment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: - 30 patients with obsessive-compulsive diagnosis according to DSM-V (with cleaning and or symmetry dimensions) 30 health controls Exclusion Criteria: - doing any kind of behavioral therapy in the moment

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: attentional bias modification, placebo<br>Measure of attentional bias modification treatment after 10 sessions of attentional bias modification (two arms). There are two arms with 15 OCD patients each one. | Behavioral: attentional bias modification treatment<br>* The attentional bias modification treatment is a behavioral computerized program (software e-prime)<br>|
| Active Comparator: attentional bias modification, active group<br>Measure of attentional bias modification treatment after 10 sessions of attentional bias modification (two arms). | Behavioral: attentional bias modification treatment<br>* The attentional bias modification treatment is a behavioral computerized program (software e-prime)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percentage of reduction of attentional bias |  | Patients will be followed an expected average of 7 weeks (baseline, 2 sessions per week - totalizing 5 weeks, 10 sessions and a session after end of treatment). Measures of attentional bias will be assessed in baseline, session 5 and after session 10. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Reduction of anxiety symptoms |  | Baseline, session 5 and end of treatment (after session 10) (expected average of 7 weeks) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Attentional Bias, Attentional Bias modification treatment