Screening Strategy for Early Diagnosis of Silicosis in At-Risk Populations in Oklahoma

Study Overview
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Brief Summary
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Silicosis, a preventable yet irreversible occupational lung disease, has an insidious onset with a latency period for diagnosis extending beyond 10 years from the initial exposure. The central hypothesis of this study is that silicosis cases may currently be going undetected. The long-term goal of this research is to determine the current prevalence and forecast the future prevalence of silicosis and other pneumoconiosis among working populations in Oklahoma and to assist the public health and the healthcare system in planning for a potential resurgence of silicosis.

Official Title
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Screening Strategy for Early Diagnosis of Silicosis in At-Risk Populations in Oklahoma

Conditions
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Silicosis, Pneumoconiosis; Silica

Intervention / Treatment
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* Diagnostic Test: Tuberculosis test
* Diagnostic Test: Chest X-ray
* Diagnostic Test: Pulmonary Function Test


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Male 30 years or older Past or present employment in dusty environment, exposed to dust at work Ability to consent and answer the questionnaire Exclusion Criteria: Female Never exposed to dusty environment or never exposed to dust at work Inability to consent and answer the questionnaire Age 29 years or younger

Ages Eligible for Study
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Minimum Age: 30 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: Tuberculosis test|Tuberculosis (TB) test: A blood sample is collected for lab testing to determine if you have tuberculosis (QuantiFeron test). Alternatively, the test is done by injecting a small amount of fluid (called tuberculin) into the skin on the lower part of the arm. A person given the tuberculin skin test must return within 48 to 72 hours to have a trained health care worker look for a reaction on the arm.|
|Diagnostic Test: Chest X-ray|Chest X ray: non-invasive medical test that helps physicians diagnose and treat medical conditions of the lungs and chest. The Chest X-ray will be done to check for abnormalities on the lungs. The test is non-invasive.|
|Diagnostic Test: Pulmonary Function Test|A pulmonary function test (PFT, spirometry) is a breathing test that measures how much air your lungs can hold as well as how hard and fast you can blow air out of your lungs. The test is not invasive and involves blowing into a machine.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Estimate of average cumulative respirable crystalline silica exposure (semi-quantitative) | Estimate of average cumulative respirable crystalline silica exposure (semi-quantitative) | Single point assessment at baseline survey | 
| Percentage of participants who report any exposure to silica | Percentage of participants who report any exposure to silica | Single point assessment at baseline survey | 
| Prevalence of silicosis among study group | Percentage of participants with confirmed diagnosis of silicosis | Single point assessment at clinic visit | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Analysis to determine if any demographic, work history, or other trait correlates with increased silica exposure | Analysis to determine if any demographic, work history, or other trait correlates with increased silica exposure | Single point assessment at baseline survey | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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silica, public health, early prevention, silicosis, screening, Oklahoma, lung disease, pulmonology, Pneumoconiosis, lung, dust exposure, occupational health, community health