Stroke Recovery Research Based on EEG-fMRI

Study Overview
=================
Brief Summary
-----------------
This study is aimed to investigate the post-stroke motor recovery of patients with ischemic stroke based on their neural features extracted from EEG-fMRI data.

Detailed Description
-----------------
A group of patients with ischemic stroke and age/gender matched healthy controls would be enrolled in this study. Their features of neural activities based on EEG-fMRI fusion scan would be extracted to investigate the mechanisms of motor recovery after stroke. Particularly, the correlations of their features of neural networks or local activities to their motor function (defined as their Fugl-Meyer scores) at enrollment and their recovery time courses consisted of Fugl-Meyer scores in follow-up time points.

Official Title
-----------------
Motor Recovery of Stroke Patients Based on Electroencephalogram-functional Magnetic Resonance Imaging

Conditions
-----------------
Motor Neuropathy

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age above 18 and below 75 years Motor impairment in National Institutes of Health Stroke Scale 7-14 days since stroke attack First-ever ischemic stroke Exclusion Criteria: Motor impairment induced by non-stroke aetiology Claustrophobia; recognition disorder History of other severe central nervous system diseases Any signs unfit for MRI/EEG scan

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Recovery<br>We would use recovery rate defined as difference between Fugl-meyer scores in the end of follow-up(eF) and in the enrollment (sF) normalized by sf to indicate the recovery Level of a patients, i.e., (eF-sF)/sF. A previously reported recovery rate, i.e., proportional recovery((eF-sF)/sF=0.7) was chosen as a standard of recovery. Hierarchial cluster method would be used to divide patients into Recovery and Non-recovery group. The Recovery group indicates that patients showed proportional Recovery determined by hierarchial cluster. | |
| Non-Recovery<br>The Non-Recovery group indicates that patients fail to show proportional recovery. | |
| Healthy Control<br>Age/sex matched healthy subjects enrolled to compare with group of patients. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fugl-Meyer scores (T0) | a scale widely used to evaluate one's motor impairment | 7-14 days since stroke | 
| Fugl-Meyer scores (T1) | a scale widely used to evaluate one's motor impairment | 6 weeks since stroke | 
| Fugl-Meyer scores (T2) | a scale widely used to evaluate one's motor impairment | 12 weeks since stroke | 
| Fugl-Meyer scores (T3) | a scale widely used to evaluate one's motor impairment | 72 weeks since stroke | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Neuroimage features based on EEG-fMRI (T0) | Neuroimage features extracted from EEG-fMRI data | 7-14 days since stroke | 
| Neuroimage features based on EEG-fMRI (T1) | Neuroimage features extracted from EEG-fMRI data | 6 weeks since stroke | 
| Neuroimage features based on EEG-fMRI (T2) | Neuroimage features extracted from EEG-fMRI data | 12 weeks since stroke | 
| Neuroimage features based on EEG-fMRI (T3) | Neuroimage features extracted from EEG-fMRI data | 72 weeks since stroke | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
motor function recovery, ischemic stroke, EEG-fMRI, neural plasticity