Laparoscopic Management of Gastrointestinal Stromal Tumor of Stomach

Study Overview
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Brief Summary
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Gastric GISTs are rare neoplasms that require excision for cure. Although the feasibility of laparoscopic resection of gastric GIST less than 2cms has been established, the feasibility, safety and long-term efficacy of these techniques for larger lesions are unclear. Investigators hypothesized that laparoscopic resection of gastric GISTs even for larger lesions is feasible & results in low perioperative morbidity and an effective long-term control of the disease.

Detailed Description
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Open surgical resection was the standard of treatment until two decades ago, but with advent laparoscopy and experienced gained over the years, the safety & feasibility of laparoscopic resections of gastric GISTs has been proven but for tumors less than 2 cm. However, with gain of experience and skill in laparoscopic surgery, many surgeons have reported a safety & feasibility excision of tumors greater than 5 cm. Our current study demonstrates the oncologic safety of the laparoscopic approach even with tumour size range up to 12cm, with efficacy and recurrence rates similar or superior to historical open surgical controls, however, it requires considerable expertise for safe manipulation of the tumour. All these resections were accomplished with minimal morbidity, no perioperative mortality, and short post-operative stay and comparable long term oncological outcomes.

Official Title
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Gastrointestinal Stromal Tumor of Stomach: Feasibility of Laparoscopic Resection in Large Lesions and Its Long Term Outcomes- A Case Series

Conditions
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Gastric GIST, Submucosal Tumor of Stomach

Intervention / Treatment
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* Procedure: Laparoscopic resection


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Gastric GIST>2cm size Exclusion Criteria: Metastatic GIST, not fit for GA

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| gastric GIST<br>patients with suspected gastric GIST with size > 2cm are subjected for laparoscopic resection. | Procedure: Laparoscopic resection<br>* all patients with suspected Gastric GIST undergoes laparoscopic resection. Tumour location decides the approach used for resection. Therefore, a variety of options such as local resections, wedge resections, transgastric resections, intragastric resection and partial gastrectomies were performed.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| rates of intraoperative tumour rupture | Any instances of tumour rupture during surgery is noted. | intraoperative | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Gastric GISTs, Submucosal tumours, Benign gastric lesions, Laparoscopic wedge resection