Preventing HIV/Aids in Drug Abusing Youth

Study Overview
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Brief Summary
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This project involves two studies focusing on the engagement and treatment of adolescents diagnosed with substance use disorders. Study 1 will evaluate a promising parent-based engagement intervention, Community Reinforcement Training, designed to facilitate the entry of resistant drug-abusing adolescents in treatment. The approach will be compared with an Engagement As Usual intervention condition. Study 2 involves a controlled clinical trial evaluating the efficacy of an HIV/AIDS prevention intervention embedded in family-based drug abuse treatment for reducing HIV/AIDS risk behaviors and substance use. Adolescents who are successfully engaged in treatment through Study 1 will be randomly assigned to receive either family therapy alone or family therapy with the integrated HIV/AIDS prevention intervention. Both studies are being conducted in Portland, Oregon.

Official Title
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Preventing HIV/Aids in Tx-Resistant Drug-Abusing Youth

Conditions
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HIV Infections

Intervention / Treatment
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* Behavioral: IBFT /HIV prevention
* Behavioral: IBFT


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Parents have an adolescent in the ages of 15-20 years. Have had contact with the adolescent on at least 40% of the past 90 days. Have some knowledge or evidence that the adolescent would meet DSM-IV diagnostic criteria for a substance abuse disorder. Adolescent has explicitly refused to attend any intake or therapy sessions. All parents' efforts to enter adolescent into treatment have failed, despite therapist's assistance. Residence in Portland vicinity. Sufficient residential stability to permit probable contact at follow-up. (e.g. not homeless at time of intake) Exclusion Criteria: Evidence of psychotic or organic state of sufficient severity to interfere with understanding of study instruments and procedures. Adolescent has received residential drug treatment longer than a 2-week period in the past 90 days.

Ages Eligible for Study
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Minimum Age: 15 Years
Maximum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: 1<br>Family Therapy plus HIV prevention | Behavioral: IBFT /HIV prevention<br>* Integrated Behavioral and Family Therapy (IBGT) with HIV prevention.<br>|
| Active Comparator: 2<br>Family Therapy only. | Behavioral: IBFT<br>* Integrated Behavioral and Family Therapy (IBFT).<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in adolescent's substance use. |  | 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in HIV risk behaviors. |  | 12 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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substance abuse, HIV risk, Behavior and Mental Disorders, HIV Seronegativity