Ultraviolet Radiation Forecasting Based Heliotherapy For Psoriasis in Bangkok, Thailand

Study Overview
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Brief Summary
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Due to limited number of phototherapy centres and shortage of qualified phototherapy practitioners, heliotherapy has become a promising treatment alternative in Thailand where patients effortlessly receive supervised sun-bathing treatments from their homes whenever they are convenient. We used newly designed deep neural network UV forecasting model developed by using our 10 year-retrospective Solar UV irradiance (280-400 nm) retrieved from a ground based platform at Atmosperic laboratory, Silpakorn University, Nakhon Pathom, Thailand (13.82N 100.04E, 30 m above mean sea level). This model achieved a next-day forecast error of less than 12% which has been the most accurate prediction to date. We designed our 10week heliotherapy regimen based on the predicted anti psoriasis effective irradiance values. We studied efficacy and safety of the 12-week heliotherapy regimen for psoriasis on only ruled acceptable clear sky days in Bangkok, Thailand

Detailed Description
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We studied efficacy and safety of the 16-week heliotherapy regimen for psoriasis on only ruled acceptable clear sky days in Bangkok, Thailand

Official Title
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The Study of Efficacy and Safety of UV Forecasting Based Heliotherapy For Psoriasis in Bangkok, Thailand: A Split-side Pilot Study

Conditions
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Psoriasis Vulgaris

Intervention / Treatment
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* Other: Heliotherapy (a sole sun-bathing)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: A psoriasis patient who indicate to have phototherapy and have lesional plagues systemically either on the front-back or left-right. A participant is based in Bangkok A participant is capable to understand and learn how to use our in-house assembled UV metre and web-based heliotherapy platform. Exclusion Criteria: A participant has any sun-sensitive conditions including photo-aggravated photodermatoses and on photosentisitive drug treatments. Breast-feeding, pregnant individuals.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Heliotherapy<br>will receive 16-week heliotherapy regimen based on the predicted anti psoriasis effective irradiance values along with olive oil (in-house formulation) | Other: Heliotherapy (a sole sun-bathing)<br>* 16-week heliotherapy regimen based on the predicted anti psoriasis effective irradiance values.<br>|
| No Intervention: Control<br>only will receive olive oil (in-house formulation) | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes of Targeted PASI score | PASI score for targeted plagues will be evaluated by two independent dermatologists (EB, PA) from standard digital photographs. | 16 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of possible acute side effects after sun bathing | Potential acute effects of the exposure of full-spectrum solar radiation | 16 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Heliotherapy, sun-bathing, psoriasis, ultraviolet radiation, forecasting, Thailand