How Astigmatism Influences Corneal Biomechanics and Intraocular Pressure

Study Overview
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Brief Summary
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The aim of the study was to identify whether preoperative corneal astigmatism can influence corneal biomechanics and the assessment of intraocular pressure (IOP) following micro-incision phacoemulsification.

Official Title
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Impact of Preoperative Astigmatism on Corneal Biomechanics and Accurate Intraocular Pressure Measurement After Micro-incision Phacoemulsification

Conditions
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Cataract Senile, Corneal Astigmatism, Intraocular Pressure

Intervention / Treatment
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* Diagnostic Test: non-contact measurement of intraocular pressure


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: diagnosis and qualification for cataract surgery, corneal astigmatism of equal to or less than 2.25 Dcyl Exclusion Criteria: corneal astigmatism higher than 2.25 Dcyl, history of any other corneal disease (infection, trauma, ulceration, autoimmune inflammation, Fuchs Dystrophy, keratoconus, corneal scars, preoperative insufficiency of corneal endothelium), glaucoma and chronic use of non-glaucoma eye drops, blepharitis, dry eye, use of contact lenses diabetes or a history of corneal refractive surgery

Ages Eligible for Study
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Minimum Age: 52 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: non-contact measurement of intraocular pressure|Non-contact measurement of corneal biomechanical properties and intraocular pressure with an Ocular Response Analyzer. Parameters measured: corneal hysteresis (CH), corneal resistance factor (CRF), Goldman-correlated IOP (IOPg), corneal compensated IOP (IOPcc) and waveform score (WS).|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change of corneal compensated IOP (IOPcc) | Intraocular pressure and corneal biomechanical properties were measured using an Ocular Response Analyzer. | Parameter measured preoperatively and one day, one week, one month postoperatively | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change of corneal hysteresis (CH) | Intraocular pressure and corneal biomechanical properties were measured using an Ocular Response Analyzer. | Parameter measured preoperatively and one day, one week, one month postoperatively | 
| change of corneal resistance factor (CRF) | Intraocular pressure and corneal biomechanical properties were measured using an Ocular Response Analyzer. | Parameter measured preoperatively and one day, one week, one month postoperatively | 
| change of Goldman-correlated IOP (IOPg) | Intraocular pressure and corneal biomechanical properties were measured using an Ocular Response Analyzer. | Parameter measured preoperatively and one day, one week, one month postoperatively | 
| change of waveform score (WS) | Intraocular pressure and corneal biomechanical properties were measured using an Ocular Response Analyzer. | Parameter measured preoperatively and one day, one week, one month postoperatively | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Corneal astigmatism, Cataract surgery, Corneal hysteresis, Corneal resistance factor, Intraocular pressure