The Feasibility of a Prehabilitation Program in the Liver Transplant Population at Barnes-Jewish Hospital

Study Overview
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Brief Summary
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The primary outcome of this study is to demonstrate the feasibility of a prehabilitation program at Barnes Jewish Hospital for liver transplant candidates. Those patients who consent to participate in the study and are placed on the transplant list will be randomized into either the control or intervention group. The intervention group receives a personalized home exercise program along with weekly phone calls to provide coaching, mentoring and motivation. Data collected at baseline, post-transplant and, post-transplant follow up will be compared among the two study groups. The secondary outcomes include: normative data of functional measures for patients with end stage liver disease and to determine the effect size for future research on prehabilitation in the patient population.

Official Title
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The Feasibility of a Prehabilitation Program in the Liver Transplant Population at Barnes-Jewish Hospital

Conditions
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End Stage Liver Disease, Physical Activity

Intervention / Treatment
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* Procedure: Exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Being evaluated for liver transplantation by Barnes Jewish Hospital medical team Exclusion Criteria: Non-english speaking Medical contraindications to exercise as determined by the medical team

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 99 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Control Group<br>Subjects will receive standard care both pre and post transplant. | |
| Experimental: Exercise Group<br>Subjects will receive a personalized home exercise program and regular phone calls from a therapist to monitor and promote activity. | Procedure: Exercise<br>* Subjects will be given and individualized exercise program.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Feasibility of a prehabilitation program. | Feasibility will be measured by participation and outcome assessment measures. | 2 Years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Normative data on Timed Up and Go for patients with end stage liver disease. |  | Baseline | 
| Normative data on 10 meter walk for patients with end stage liver disease. |  | Baseline | 
| Normative data on Modified Dynamic Gait Index for patients with end stage liver disease. |  | Baseline | 
| Normative data on Five Time Sit to Stand for patients with end stage liver disease. |  | Baseline | 
| Normative data on 6 Minute Walk Test for patients with end stage liver disease. |  | Baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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liver diseases, liver transplantation, preoperative care, physical therapy