Intensive Care Unit Activity in France From the National Database Between 2013 and 2019

Study Overview
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Brief Summary
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Using data from the French National Uniform Hospital Discharge Database (systematically collecting administrative and medical information related to all hospitalized patients in France for care reimbursement purposes), the present study retrospectively assesses the activity of the French Intensive Care Unit (ICU)(1,594,801 ICU admissions): In-ICU and in-hospital mortality rates Length of stay in ICU and hospital Mortality-associated factors during the study period. Number of organ failures Bed occupancy, Regional variations in previous indicators

Official Title
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Intensive Care Unit Activity in France From the National Database Between 2013 and 2019: More Critically Ill Patients, Shorter Stay and Lower Mortality Rate

Conditions
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Critical Illness, Intensive Care Unit

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All adults patients admitted in French ICU between January 1st, 2013, to December 31st, 2019

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| ICU ADMISSION<br>All patients admitted in a French intensive care unit over a 7-year period (2013 to 2019) using the French National Uniform Hospital Discharge Database (PMSI) | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evolution in mortality rate | evolution of the mortality rate of ICU patients over the study period (2013-19) | from January 1st, 2013, to December 31st, 2019 | 
| Evolution in organ failure rate | evolution of the organ failure rate of ICU patients over the study period (2013-19) | from January 1st, 2013, to December 31st, 2019 | 
| Evolution in ICU stay | evolution of the ICU stay of ICU patients over the study period (2013-19) | from January 1st, 2013, to December 31st, 2019 | 
| Evolution in SAPS (Simplified Acute Physiology Score) II score at admission | evolution of the SAPS II score at admission of ICU patients over the study period (2013-19) | from January 1st, 2013, to December 31st, 2019 | 
| Evolution in age at admission | evolution of the age at admission of ICU patients over the study period (2013-19) | from January 1st, 2013, to December 31st, 2019 | 
| Evolution in sex ratio | evolution of the sex ratio of ICU patients over the study period (2013-19) | from January 1st, 2013, to December 31st, 2019 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Proportion of patients admitted in ICU with at least 2 different organ failures | evolution of the proportion of patients admitted in ICU with at least 2 different organ failures corresponding to the definition of ICU in France. | from January 1st, 2013, to December 31st, 2019 | 
| - Proportion of patients admitted in ICU with a SAPS II score over 15 and with a specific ICU supportive therapy | Evolution of the proportion of patients admitted in ICU with a SAPS II score over 15 and with a specific ICU supportive therapy leading to a reimbursement by the French national health insurance. | from January 1st, 2013, to December 31st, 2019 | 
| Factors Associated with in-ICU mortality | Effect of year-time on in-ICU mortality | from January 1st, 2013, to December 31st, 2019 | 
| Regional variations | Evolution and potential differences between French regions in admission level | from January 1st, 2013, to December 31st, 2019 |