High-Field MRI Characterization of Wrist and Hand Cartilage Abnormalities in Inflammatory and Chronic Rheumatisms

Study Overview
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Brief Summary
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The present project aims at evaluating the diagnostic potential of high-field MRI (3 Teslas) for joint disease. At this field, given that isotropic image resolution of 400 microns can be obtained, one could expect an early detection of joint abnormalities. The additional aim of this project will be to develop a quantitative analyse of the corresponding high-resolution images.

Official Title
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High-Field MRI Characterization of Wrist and Hand Cartilage Abnormalities in Inflammatory and Chronic Rheumatisms

Conditions
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Abnormality, Inflammation, Rheumatism

Intervention / Treatment
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* Other: high-field MRI (3 Teslas)
* Other: high-field MRI (3 Teslas)
* Other: high-field MRI (3 Teslas)
* Other: high-field MRI (3 Teslas)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: gp Suspects or affected by rheumatoid polyarthritis Morning articular Stiffness of at least 15 minutes. Arthalgias or Arthritises of at least three joints(articulations), among which those of the hand. Possible rheumatoid Presence of a factor(mailman) and\or Antibody anti peptides positive citrullinés. Typical possible radiological Hurts on the standard clichés(pictures) of the reached(affected) joints(articulations). gp Affected by stiffening spondylitis with axial and peripheral infringement : . Lumbago and steepness lumbar vertebra inflammatory. 2. Arthralgias and\or peripheral arthritises 3. Possible presence of an allèle HLA 4. Possible presence of a sacro-illite 5. Absence of the other rheumatic markers gp Affected by connectivity with anti-nuclear antibody positive and / or specific antibodies, suffering of polyarthralgias with or without arthritis gp Healthy control gp Presenting a degenerative osteoarthritis of the wrist traumatic comment, noticed radiologically, which will serve as not inflammatory control. Exclusion Criteria: Claustrophobia, metallic foreign bodies, pacemakers The pregnant women, parturients or who breast-feed are excluded from the study

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Suspects or affected by rheumatoid polyarthritis<br> | Other: high-field MRI (3 Teslas)<br>* high-field MRI (3 Teslas)<br>|
| Other: stiffening spondylitis with axial and peripheral infringement<br> | Other: high-field MRI (3 Teslas)<br>* high-field MRI (3 Teslas)<br>Other: high-field MRI (3 Teslas)<br>* high-field MRI (3 Teslas)<br>|
| Other: polyarthralgies with or without arthritis<br>Affected by connectivity with anti-nuclear antibody positive and / or specific antibodies, suffering of polyarthralgias with or without arthritis | Other: high-field MRI (3 Teslas)<br>* high-field MRI (3 Teslas)<br>Other: high-field MRI (3 Teslas)<br>* high-field MRI (3 Teslas)<br>|
| Other: Healthy control<br> | Other: high-field MRI (3 Teslas)<br>* high-field MRI (3 Teslas)<br>Other: high-field MRI (3 Teslas)<br>* high-field MRI (3 Teslas)<br>|
| Other: not inflammatory control<br>Presenting a degenerative osteoarthritis of the wrist traumatic comment, noticed radiologically, which will serve as not inflammatory control. | Other: high-field MRI (3 Teslas)<br>* high-field MRI (3 Teslas)<br>Other: high-field MRI (3 Teslas)<br>* high-field MRI (3 Teslas)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| can be obtained, one could expect an early detection of joint abnormalities |  | 24 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| will be to develop a quantitative analyse of the corresponding high-resolution images. |  | 24 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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wrist and hand cartilage abnormalities in inflammatory and chronic rheumatisms