The Role of Genetic Factors in the Development of Myocardial Infarction in the Kazakh Population

Study Overview
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Brief Summary
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This is a GWAS study that aims to identify possible candidate genes associate to heart attack by exploring single nucleotide polymorphism (SNP) in a group of heart attack, in the Kazakh population. The investigators hypothesize that the careful phenotyping of the subject sand matching with increase the power to find SNP significantly associate with heart attack

Detailed Description
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A genome-wide association study (GWAS) is an approach used in genetics research to associate specific genetic variations with particular diseases. The method involves scanning the genomes from many different people and looking for genetic markers that can be used to predict the presence of a disease. Once such genetic markers are identified, they can be used to understand how genes contribute to the disease and develop better prevention and treatment strategies.

Official Title
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Preventive and Personalized Medicine (2021-2023)

Conditions
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Heart Attack

Intervention / Treatment
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* Genetic: DNA analysis


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Persons of Kazakh nationality Age up to 59 years inclusive at the time of primary myocardial infarction Myocardial infarction was established in accordance with the EOC criteria: An increase and / or decrease in the level of cardiac troponin must be combined with at least one of the following: • Symptoms of myocardial ischemia • Newly occurring ischemic changes on the ECG • The appearance of a pathological Q wave • Identification according to imaging data methods of new areas of non-viable myocardium, or new areas of local contractility disorders of presumably ischemic etiology • Detection of a thrombus in the coronary arteries according to coronary angiography Presence of coronary angiography Persons able and willing to provide written informed consent; Exclusion Criteria: Age at primary myocardial infarction 60 years and older Heart defects, congenital and acquired Non-ischemic cardiomyopathies Autoimmune diseases Diabetes mellitus at the time of development of primary myocardial infarction Terminal stages of renal and hepatic failure

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental group:<br>Patients with Heart Attack | Genetic: DNA analysis<br>* GWAS<br>|
| Control group<br>Patients without Heart Attack | Genetic: DNA analysis<br>* GWAS<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| number of SNPs associated with Heart Attack | Using GWAS to identify candidate genes associate with Heart Attack | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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GWAS