Minimum Effective Volume of Lidocaine Costoclavicular Brachial Plexus Block

Study Overview
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Brief Summary
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The aim of this study is to determine the minimum effective volume of lidocaine in 90% of patients (ED90) required for single-injection US-guided costoclavicular infraclavicular.

Detailed Description
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The aim of this study is to determine the minimum effective volume of lidocaine in 90% of patients (ED90) required for single-injection US-guided costoclavicular ICB. Determination of the minimum effective volume of LA is important because it prevents the administration of an unnecessarily large (and potentially toxic) dose. Furthermore, when multiple blocks need to be performed at the same time in the same patient, knowledge of the minimum effective volume allows to the operator to preserve efficacy without sacrificing safety for each block.

Official Title
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Minimum Effective Volume of Lidocaine for Ultrasound-Guided Costoclavicular Infraclavicular Brachial Plexus Block

Conditions
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Upper Extremity Surgery

Intervention / Treatment
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* Other: costoclavicular nerve block


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age between 18 and 70 years American Society of Anesthesiologists classification 1-3 body mass index between 20 and 30 Exclusion Criteria: adults who are unable to give their own consent pre-existing neuropathy (assessed by history and physical examination) coagulopathy (assessed by history and physical examination and, if deemed clinically necessary, by blood work up i.e. platelets≤ 100, International Normalized Ratio≥ 1.4 or partial prothrombin time ≥ 50) renal failure (assessed by history and physical examination and, if deemed clinically necessary, by blood work up i.e. creatinine≥ 100) hepatic failure (assessed by history and physical examination and, if deemed clinically necessary, by blood work up i.e. transaminases≥ 100) allergy to local anesthetics pregnancy prior surgery in the infraclavicular region chronic pain syndromes requiring opioid intake at home

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: costoclavicular inflaclavicular block<br>costoclavicular block with similar volume | Other: costoclavicular nerve block<br>* ultrasound-guided costoclavicular nerve block<br>|
| Experimental: costoclavicular block<br>costoclavicular block with decreasing volume | Other: costoclavicular nerve block<br>* ultrasound-guided costoclavicular nerve block<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| success rate | minimal composite score of 14 out of 16 | 0-30 min |