S0718 Pazopanib and Temsirolimus in Treating Patients With Advanced Solid Tumors

Study Overview
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Brief Summary
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RATIONALE: Pazopanib and temsirolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Pazopanib may also blocking blood flow to the tumor. Giving pazopanib together with temsirolimus may be an effective treatment for advanced solid tumors. PURPOSE: This phase I trial is studying the side effects and best dose of temsirolimus when given together with pazopanib in treating patients with advanced solid tumors.

Detailed Description
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OBJECTIVES: To investigate the safety and feasibility of temsirolimus and pazopanib when given in combination in patients with advanced solid tumors. To recommend the maximum tolerated dose of this regimen in these patients. To investigate the pharmacokinetics of temsirolimus alone and in combination with pazopanib in these patients. To investigate the effects of this regimen on relevant biological markers. To preliminarily report objective response in patients treated with this regimen. OUTLINE: This is a multicenter study. Patients receive temsirolimus IV over 30 minutes on days 1, 8,15, and 22 and oral pazopanib hydrochloride once daily on days 4-28 in course 1 and days 1-28 in all subsequent courses. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity. Blood samples are obtained periodically for evaluation of the pharmacokinetics of temsirolimus and pazopanib, plasma and serum angiogenic and cachectic factors (e.g., VEGF, bFGF, PlGF and SDF-1) by enzyme-linked immunosorbent assay, and biological markers in the mTOR/PI3/Akt, Ras/MAPK, VEGFR, PDGFR, and HIF-1 pathways. After completion of study therapy, patients are followed for 28 days.

Official Title
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S0718: Phase I Study Evaluating The Combination of GW786034 (Pazopanib; NSC-737754; IND-XXXX) and CCI-779 (Temsirolimus; NSC-683864; IND-XXXX) in Patients With Advanced Solid Tumors

Conditions
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Unspecified Adult Solid Tumor, Protocol Specific

Intervention / Treatment
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* Drug: pazopanib hydrochloride
* Drug: temsirolimus
* Procedure: immunoenzyme technique
* Procedure: laboratory biomarker analysis
* Procedure: pharmacological study


Participation Criteria
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Eligibility Criteria
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DISEASE CHARACTERISTICS: Cytologically or pathologically verified cancer that is of advanced stage and for which there is no effective therapy No lymphoma Measurable or nonmeasurable disease Previously irradiated (whole brain or gamma knife) brain metastases allowed provided there is no requirement for corticosteroids or anticonvulsants PATIENT CHARACTERISTICS: Zubrod performance status 0-2 ANC ≥ 1,500/mm³ Platelet count ≥ 100,000/mm³ Hemoglobin ≥ 9 g/dL (without transfusions) AST and ALT ≤ 2.5 times upper limit of normal (ULN) (≤ 5 times ULN if liver metastases present) Bilirubin normal Serum creatinine ≤ 1.5 times ULN OR measured creatinine clearance OR calculated creatinine clearance ≥ 60 mL/min QTC interval < 480 msec on baseline ECG OR average QTC < 480 msec on baseline plus 2 additional screening ECG's Fasting cholesterol < 350 mg/dL Fasting triglycerides < 400 mg/dL No uncontrolled hypertension, arterial thrombotic event, or bleeding on therapeutic anticoagulation with warfarin or heparin (including low molecular weight heparin) within the past 6 months Able to swallow enteral medications No feeding tubes No intractable nausea or vomiting No gastrointestinal (GI) tract disease resulting in an inability to take oral medication, malabsorption syndrome, a requirement for IV alimentation, prior surgical procedures affecting absorption, or uncontrolled inflammatory GI disease (e.g., Crohn, ulcerative colitis) No history of allergic reactions attributed to compounds of similar chemical or biologic composition to rapamycin analogs (e.g., sirolimus and everolimus) No known HIV positivity No uncontrolled intercurrent illness including, but not limited to, the following: Ongoing or serious active infection Symptomatic congestive heart failure Unstable angina pectoris Serious cardiac arrhythmia History of myocardial infarction Cerebrovascular accident within 3 months of study entry Uncontrolled diarrhea Psychiatric illness or social situation that would limit compliance with study requirements Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception, including barrier methods Willing to undergo pharmacokinetic (PK) sampling and blood submission for PK and translational medicine studies PRIOR CONCURRENT THERAPY: Recovered from all prior therapy No prior pazopanib hydrochloride or temsirolimus More than 28 days since prior major surgery, chemotherapy, biologic therapy, or immunotherapy More than 28 days since prior investigational agents At least 14 days since prior radiotherapy No concurrent rapamycin (sirolimus) No concurrent enzyme-inducing antiepileptic drugs (e.g., phenytoin, carbamazepine, or phenobarbital), CYP3A4 inducers (e.g., rifampin or St. John's wort), or CYP3A4 inhibiting agents or substrates (e.g., ketoconazole, diltiazem, or verapamil) No concurrent chemotherapy, hormonal therapy, radiotherapy, immunotherapy, or any other type of therapy for treatment of this cancer while on this protocol No live vaccines Luteinizing-hormone releasing-hormone agonists allowed Concurrent prophylactic warfarin (≤ 1 mg/day) allowed Concurrent bisphosphonate or erythropoietin or its analogue allowed, if deemed appropriate by the treating physician

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: pazopanib hydrochloride|nan|
|Drug: temsirolimus|nan|
|Procedure: immunoenzyme technique|nan|
|Procedure: laboratory biomarker analysis|nan|
|Procedure: pharmacological study|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Safety as assessed by NCI CTCAE v3.0 |  |  | 
| Feasibility of the drug combination |  |  | 
| Maximum tolerated dose of temsirolimus in combination with pazopanib |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pharmacokinetics of temsirolimus alone and in combination with pazopanib |  |  | 
| Relevant biological markers |  |  | 
| Objective response as assessed by RECIST criteria |  |  | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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unspecified adult solid tumor, protocol specific