Adaptive Treatment for Adolescent Cannabis Use Disorders

Study Overview
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Brief Summary
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The purpose of this study is to examine an Adaptive Treatment approach in order to improve outcomes of youth with Cannabis Use Disorders who are poor responders to treatment.

Detailed Description
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The study will address the current contrasts in youth response to treatment, the problem of poor response to treatment and the prevention of relapse. Results from the study may support Adaptive Treatment as an efficacious approach for youth with Cannabis Use Disorder who are poor responders to treatment. Poor responders fall into two categories, those who failed to achieve a negative drug urinalysis during the last session of the initial MET/CBT-7 treatment they attended, and those who either dropped out or were administratively discharged at any time during the initial MET/CBT-7 treatment.

Official Title
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Adaptive Treatment for Adolescent Cannabis Use Disorders

Conditions
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Mental Disorders, Addictive Behaviors, Cannabis Use Disorder

Intervention / Treatment
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* Behavioral: ACRA
* Behavioral: CBT


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 13-18 years of age at the time of intake assessment Current diagnosis of DSM-IV Cannabis Abuse or Dependence Able to read and comprehend English at a 5th grade level Residence within 45 minutes drive from the UCHC Farmington treatment site Participant and a parent/legal guardian responsible for providing collateral information agree to sign an IRB approved consent form Participant and a parent/legal guardian responsible for providing collateral information agree to provide locator information The family is not planning to move from the area during the next six months Exclusion Criteria: Meet criteria for dependence of any other substance of abuse other than nicotine or alcohol Report suicidal ideation with a plan, suicidal behavior, a plan to hurt oneself or other, or a history of self-injurious behavior all occurring in the last 30 days Meet a lifetime diagnosis of schizophrenia Has any current health (i.e. medical, psychiatric) condition that will compromise the participant's ability to regularly attend treatment Demonstrate an inability or unwillingness to provide locator information

Ages Eligible for Study
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Minimum Age: 13 Years
Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: ACRA<br>Ten weekly 60-minute sessions of Adolescent Community Reinforcement Approach (ACRA) will be provided as an Adaptive treatment condition. | Behavioral: ACRA<br>* Ten weekly,60-minute therapy sessions including six individual, two parent/guardian and two joint (individual and parent/guardian).<br>* Other names: Adolescent Community Reinforcement Approach;|
| Experimental: Cognitive Behavioral Therapy (CBT)<br>Ten weekly, 60-minute sessions of augmented individualized Cognitive Behavioral Therapy (CBT)will be provided as an Adaptive Treatment condition | Behavioral: CBT<br>* 10 weekly, 60-minute sessions of augmented individualized CBT<br>* Other names: Cogntive Behavioral Therapy;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 1.) To evaluate the efficacy of AT for youth who have been defined as poor responders to an evidence-based practice intervention such as the initial MET/CBT-7. | Each participant will serve as his/her own control. The outcomes will include the T-ASI, T-ASI-P, and drug urinalyses. | one year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To assess outcomes as a function of mediator variables such as self-efficacy, coping skills, readiness to change, and environmental support (i.e., family and peer), within each of the AT interventions. | The secondary outcome measures will include the SCQ, CRI, PRQ, and SSQ. | one year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Adolescents, Substance Use Disorders