Biological Consequences of an Ultra Endurance Race

Study Overview
=================
Brief Summary
-----------------
The aim is to study per and post-exertion variations of biological markers during an ultra-endurance race

Detailed Description
-----------------
25 healthy adult volunteers participating in the 100 miles South of France 2017© race recruited electronically by an announcement on the race website

Official Title
-----------------
Per Effort Study of Biological Consequences of an Ultra Endurance Race (165km)

Conditions
-----------------
Exertion; Excess

Intervention / Treatment
-----------------
* Other: Blood sample


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age greater 18 years. Subject having already completed an ultra-endurance race (distance greater than 50 kilometers) during the 24 months preceding the race. Affiliation of a social security. Exclusion Criteria: Age lower than 18 years Subjects with a medical history (pulmonary pathology, cardiac, hypertension) or having a significant chronic inflammatory disease known at the time of the inclusion visit the day before the race. Female

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Blood sample|measurement of electrolytes and blood count|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Per and post-exertion evolution of sodium blood level | Change of sodium blood level during and after the race will be measured. | Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race | 
| Per and post-exertion evolution of lactatemia | Change of lactatemia during and after the race will be measured. | Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race | 
| Per and post-exertion evolution of myoglobin blood level | Change of myoglobin blood level will be measured during and after the race | Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race | 
| Per and post-exertion evolution of creatinine phosphokinase blood level | Change of myoglobin blood level will be measured during and after the race | Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race | 
| Per and post-exertion evolution of potassium blood level | Change of potassium blood level during and after the race will be measured. | Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race | 
| Per and post-exertion evolution of chlorine blood level | Change of chlorine blood level during and after the race will be measured. | Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race | 
| Per and post-exertion evolution of glucose blood level | Change of glucose blood level during and after the race will be measured. | Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race | 
| Per and post-exertion evolution of calcium blood level | Change of calcium blood level during and after the race will be measured. | Change measures : departure, 15, 50, 65, 90, 130 and 165 kilometers then at day 1 and 2 after the completion of the race |