linjc16/ctgov huggingface dataset:
Lymphocytes Subpopulation in Cancer Patients

Study Overview
=================
Brief Summary
-----------------
This study aims to exam the subpopulation of lymphocytes and evaluate the clinico-pathologic correlations.

Detailed Description
-----------------
The host's inflammatory response in the tumor microenvironment could effect cancer progression and prognosis. As components of systemic inflammatory response, lymphocytes, neutrophils, and platelets are being recognised to have an important role in carcinogenesis and tumor progression. To date, a number of peripheral blood-derived inflammation-based scores such as the neutrophil-lymphocyte ratio (NLR), platelet- lymphocyte ratio (PLR) and so on have been proposed as prognostic markers in numerous types of cancers. But, very little is known of their impact in subpopulation of lymphocytes. The investigators try to evaluate the activity of lymphocytes in peripheral blood and find out the relationship among clinical prognosis.

Official Title
-----------------
Lymphocytes Subpopulation and Its Relevance With Tumor Grade and Prognosis in Cancer Patients

Conditions
-----------------
Cancer

Intervention / Treatment
-----------------
* Other: lymphocyte


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: cancer patients of Uijeongbu St. Mary's Hospital never treated with chemotherapy Age between 20 80 years- Exclusion Criteria: treated with chemotherapy before No informed consent form

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: lymphocytes<br>To evaluate the subpopulation of lymphocytes in cancer patients | Other: lymphocyte<br>* To evaluate the subpopulation of lymphocytes in cancer patients<br>* Other names: subpopulation of lymphocytes in cancer patients;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| response rate after cancer treatment with chemotherapy |  | 6 months after chemotherapy |
Prognostic Value of Progesterone on Oocyte Retrieval Day for In Vitro Fertilization Outcome

Study Overview
=================
Brief Summary
-----------------
This observational study aims the potential role of serum progesterone levels on the day of oocyte pick-up on the probability of pregnancy, in patients undergoing antagonist IVF cycles. There has been evidence, that increased serum levels of progesterone on triggering day are associated with a decreased probability of pregnancy after IVF. There is no study that investigate assocation between serum progesterone levels on the day of oocyte pick-up and IVF outcomes. This study will be the first in this case.

Official Title
-----------------
Prognostic Value of Progesterone Levels on Oocyte Retrieval Day for Outcome of Intracytoplasmic Sperm Injection

Conditions
-----------------
Infertility, Assisted Reproductive Technology

Intervention / Treatment
-----------------
* Other: Serum Progesterone Levels


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age < 40 years Basal FSH < 12 IU/L Basal P < 1.6 ng/mL Exclusion Criteria: Women with polycystic ovaries syndrome (PCOS) Women with Stage III-IV Endometriosis Women with a pathological condition of the adrenal glands

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 39 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Serum Progesteron Levels<br> | Other: Serum Progesterone Levels<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical pregnancy | Clinical pregnancy, defined as ultrasound evidence of gestational sac at 6 weeks of gestation | At 6-8 weeks of gestation |
A Study to Validate the Safety and Feasibility of ArtiSential in Colorectal Cancer Surgery Using Prospectively Constructed Multi-center Registry

Study Overview
=================
Brief Summary
-----------------
This study is to validate the safety and feasibility of ArtiSential (Articulating laparoscopic instrument) colorectal surgery and compare it with robotic surgery for patients with rectal cancer and rectosigmoid junction cancer.

Official Title
-----------------
A Study to Validate the Safety and Feasibility of ArtiSential in Colorectal Cancer Surgery Using Prospectively Constructed Multi-center Registry

Conditions
-----------------
Rectosigmoid Cancer, Rectosigmoid Junction Cancer, Rectal Cancer

Intervention / Treatment
-----------------
* Device: ArtiSential


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age : 18   80 year old male or female Biopsy-proven adenocarcinoma Rectal cancer or Rectosigmoid junction cancer Primary cancer Non-metastatic cancer Planned (or elective) curative resection Low anterior resection with double-stapled technique Exclusion Criteria: Preoperative systemic chemotherapy Distant metastasis at initial diagnosis Palliative surgery Emergent surgery Lynch syndrome or FAP-associated cancer

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| ArtiSential group<br>Patients undergoing laparoscopic surgery using ArtiSential | Device: ArtiSential<br>* Articulating laparoscopic instrument<br>|
| Robot group<br>Patients undergoing robotic surgery | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Surgical failure | conversion, postoperative complications, or less than 12 harvested lymph nodes | 1 month | 
| Cost | Total medical cost during hospital stay for surgery | 1 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Oncologic outcomes | 5-year Disease-free Survival | 5-year | 
| Oncologic outcomes | 5-year Overall Survival | 5-year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
laparoscopic surgery, minimally invasive surgery, robotic-assisted surgery, robotic surgery, Da Vinci system, ArtiSential, Articulating laparoscopic instrument
Community Approach to Reduce the Risks of Diabetes After Gestational Diabetes Mellitus

Study Overview
=================
Brief Summary
-----------------
Objective: The current study examined the effectiveness of a culturally-appropriate adaptation of the diabetes prevention program (DPP) curriculum in reducing type 2 diabetes risk in Latinas with a history of gestational diabetes mellitus (GDM). Research Design and Methods: Seventy-six Latinas aged 18-45 years with GDM in the past 3 years participated in an 8-week group-based, peer-educator led lifestyle intervention based on the DPP, with adaptations appropriate to Latino culture and recent mothers. Clinical and self-report indicators were assessed at baseline, post-intervention (month-3), and follow-up (month-6). Hypothesis-The modified culturally tailored DPP will improve risk factors associated with the development of type 2 DM.

Official Title
-----------------
Dulce Mothers: A Community Approach to Reduce the Risks of Developing Diabetes After Gestational Diabetes

Conditions
-----------------
Diabetes

Intervention / Treatment
-----------------
* Behavioral: Dulce Mother lifestyle training program


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 18-45 years old Latina GDM within the last 3 years able and willing to participate in physical activity sessions Exclusion Criteria: current diabetes severe illness that would preclude them from coming to the sessions

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Lifestyle<br>12 once weekly Lifestyle training program | Behavioral: Dulce Mother lifestyle training program<br>* 12 once weekly culturally tailored lifestyle management sessions<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| HbA1c |  | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| weight |  | 6 months | 
| lipids |  | 6 months | 
| blood pressure |  | 6 months | 
| composition of dietary intake at all time points |  | 6 months | 
| hours of physical activity per week at all time points |  | 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Gestational Diabetes, Prevention, Latinas
Immune Response to Hepatitis B Virus Booster Vaccination After 20-23 Years

Study Overview
=================
Brief Summary
-----------------
This study will evaluate the humoral and cellular immune responses to a hepatitis B vaccine booster in healthy adults which received a full course of neonatal hepatitis B vaccination 20-23 years ago.

Official Title
-----------------
Humoral and Cellular Immune Responses to a Hepatitis B Vaccine Booster 20-23 Years After Neonatal Immunization

Conditions
-----------------
Hepatitis B Vaccination

Intervention / Treatment
-----------------
* Biological: HBV booster vaccination 1dose


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: healthy adults 20-25 years old Exclusion Criteria: Hepatitis B surface antigen (+) Hepatitis B core antibody (+) any history of liver disorders including hepatitis HIV Ag or Ab(+)

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 25 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: HBV booster vaccination<br> | Biological: HBV booster vaccination 1dose<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change of HBsAb titer |  | 28 days after HBV booster vaccination | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| HBsAg-specific cell mediated immunity |  | 28 days after HBV booster vaccination |
Quick Recognition of Aortic Dissection

Study Overview
=================
Brief Summary
-----------------
This is an observational study that establishes a cohort of patients with high risk chest pain who have been identified by CTA for aortic dissection. We then used this cohort to validate the accuracy of identifying aortic dissection based on extremity oximetry and Doppler waveforms.

Official Title
-----------------
Identification of Aortic Dissection Based on Pulse Oxygen and Ultrasound Doppler Waveforms

Conditions
-----------------
Aortic Dissection

Intervention / Treatment
-----------------
* Diagnostic Test: Non interventional


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: High risk chest pain with CTA Exclusion Criteria: shock coma severe peripheral vascular diseases

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Aortic Dissection<br> | Diagnostic Test: Non interventional<br>* No intervention<br>|
| Non Aortic Dissection<br> | Diagnostic Test: Non interventional<br>* No intervention<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diagnosis of aortic dissection | aortic dissection confirmed by CTA | First 24-hours during emergency dapartment stay |
Determination of Optimum Age for DXA Screening for Osteoporosis in HIV - The Probono 1 Study

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine the bone mineral density in male and female patients with HIV infection according to age groups. This will enable a practical approach to screening for osteoporosis and the management and prevention of fragility fractures in people with HIV. In addition, all risk factors commonly associated with fragility fractures and osteoporosis are collected, as is HIV drug history. Hence, as secondary outcomes, the associations with reduced bone mineral density can be ascertained.

Official Title
-----------------
Prospective Study to Determine the Optimum Age for Routine DEXA Screening for Osteopenia/Osteoporosis in People With HIV Infection

Conditions
-----------------
Osteoporosis, Fractures, HIV Infection

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 18 years or above Not pregnant Able to comply with study observations and procedures Able to give fully informed consent Exclusion Criteria: Pregnant Less than 18 years of age Unable to comply with study procedures

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Controls, females<br>Controls who are presumed HIV uninfected, females, aged 18 or above | |
| Controls, males<br>Controls presumed HIV uninfected, males, aged 18 or above | |
| HIV infected patients, males<br>HIV patients, males, aged 18 or above | |
| HIV patients,<br>HIV patients, females, aged 18 or above | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Bone mineral density at Hip | Bone mineral density as determined by DXA scanning | The outcome is measured within 6 months (0-6 months) after entry to the study. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Bone mineral density at spine (L4) | As determined by DXA scan | The outcome is measured within 6 months (0-6 months) after entry to the study. | 
| Any lifetime fractures reported by subjects | Self-reported fractures of any type | At any stage during persons life up to and including the last visit for the volunteer to the study. | 
| Vitamin D levels | Plasma vitamin D | The outcome is measured within 6 months (0-6 months) after entry to the study. | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
HIV, Bone mineral density, Osteoporosis, Vitamin D, Fractures
Evaluation of Methods to Asses Visual Prosthesis Systems Using Sighted Volunteers and Visual Reality Simulator

Study Overview
=================
Brief Summary
-----------------
A basic requirement for every therapeutic procedure is that there be an objective and validated method to assess the benefit of the treatment for the patient. Currently, there is no acceptable procedure to quantify the benefit obtained from visual prostheses. The goal of the proposed research is to evaluate visual tasks and tests that will be given to a very large number of volunteers with normal vision who will be using a novel virtual prosthesis simulator. This device will simulate the realistic visual information that a visual implant can provide and will be used to measure implants in current clinical trials.

Official Title
-----------------
Evaluation of Methods to Asses Visual Prosthesis Systems Using Sighted Volunteers and Visual Reality Simulator

Conditions
-----------------
Focus of Study: Finding Ways to Evaluate Visual Prosthesis Systems

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Normal or corrected to normal sight (up to +/- 3.5 D) - Healthy Age 18 to 45 Exclusion Criteria: Had any incident of dizziness from video or computer game Minors or special population

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| quantitative comparison with standard visual acuity test (ETDRS) |  | December 1, 2012 |
Physical Functioning Following Total Hip Arthroplasty

Study Overview
=================
Brief Summary
-----------------
Adults suffer from Osteoarthrosis of hip joint that willing to participate in the study will be tested with well-established measuring techniques of Balance control using force plate before 3 month and 6 month after Total Knee Arthroplasty (THA) in the movement and Rehabilitation Laboratory at BGU. An automated algorithm will be used to extract standardized stabilogram-diffusion parameters from each of the COP data sets collected during quiet standing. These parameters include diffusion coefficients, critical displacement, critical time and scaling exponents for both lateral and anterior-posterior sway directions (Collins & De Luca, 1993). Each of the Times (before 3 month and 6 month after the THA) in two task conditions (eyes closed and eyes close conditions). Participants will be required to stand on the platform 10 times for 30 s For each trial, they will be instructed to sway as little as possible. In addition step execution test and Late life function and disability questionnaires will be also examined.

Official Title
-----------------
Step Execution, Stability, Quality of Life, Fear of Falling and Their Association Following Total Hip Arthroplasty

Conditions
-----------------
Osteoarthrosis, Balance Control, Voluntary Movement Control

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Able to stand safely for 30 seconds Able to walk independently Hip OA prior THA Exclusion Criteria: Stroke or other neurological diseases Minimal score 24 or higher Blindness

Ages Eligible for Study
-----------------
Minimum Age: 40 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| A<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| SDF parameters |  | before, 3 month and 6 month after the THA | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Late Life Function and disability, Fall efficacy scale, step execution test |  | before 3 month and 6 month after | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Balance, Voluntary stepping, function, disability, fear of falls, Total Hip Arthroplasty
Retrospective Study of Patients With Spasticity in the Spanish Population

Study Overview
=================
Brief Summary
-----------------
This is a retrospective study of patients with spasticity in the Spanish population.

Official Title
-----------------
Observational Study To Establish The Methodology Used In The Evaluation, Treatment And Assessment Of Progression Of Spasticity In The Spanish Population

Conditions
-----------------
Muscle Spasticity

Intervention / Treatment
-----------------
* Other: No treatment


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosis of spasticity Exclusion Criteria: Current enrollment in a clinical trial

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| All Participants<br>This was a retrospective chart review in patients with spasticity in the Spanish population. There was no treatment in this study. | Other: No treatment<br>* There was no treatment in this study.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Physician Assessment of Spasticity | The physician assessed spasticity as per local standard practice. Not enough data was collected for analysis of this outcome measure. | Baseline | 
| Physician Assessment of Spasticity | The physician assessed spasticity as per local standard practice. Not enough data was collected for analysis of this outcome measure. | Month 12 |