Evolution of Aqueous Flare in Rhegmatogenous Retinal Detachments Treated With Gas or Silicone Oil Tamponade.

Study Overview
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Brief Summary
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To examine and to compare the evolution of aqueous flare from presentation until the third postoperative month in a series of consecutive patients who underwent primary vitrectomy for rhegmatogenous retinal detachment (RRD), in 4 groups of patients : Group 1 : 48 eyes primarily treated with gas tamponade Group 2 : 11 eyes primarily treated with silicone oil tamponade Sub-Group G1RG : 8 eyes among Group 1 treated with gas after relapse Sub-Group G1RS : 3 eyes among Group 1 treated with silicone oil after relapse

Official Title
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Evolution of Aqueous Flare in Rhegmatogenous Retinal Detachments Treated With Gas or Silicone Oil Tamponade.

Conditions
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Retinal Detachment

Intervention / Treatment
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* Other: Aqueous flare measurement


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: adult patients patients who underwent surgery for rhegmatogenous retinal detachment (silicone or gas tamponade) aqueous flare measurement carried out preoperatively and postoperatively at 2-4 weeks and 3 months Exclusion Criteria: diabetic retinopathy glaucoma non rhegmatogenous retinal detachment active uveitis pseudoexfoliation syndrome.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Initial gas tamponade<br>Primary vitrectomy and fluid-air exchange with SF6 or C2F6 gas tamponade | Other: Aqueous flare measurement<br>* Aqueous flare was measured preoperatively and postoperatively with a laser flare-cell meter (LFCM ; Kowa FM-500, Kowa Company Ltd, Tokyo, Japan).<br>|
| Initial silicone oil tamponade<br>Primary vitrectomy and fluid-air exchange with silicone oil tamponade | Other: Aqueous flare measurement<br>* Aqueous flare was measured preoperatively and postoperatively with a laser flare-cell meter (LFCM ; Kowa FM-500, Kowa Company Ltd, Tokyo, Japan).<br>|
| Relapse treated with gas tamponade<br>Secondary vitrectomy and fluid-air exchange with SF6 or C2F6 or C3F8 gas tamponade | Other: Aqueous flare measurement<br>* Aqueous flare was measured preoperatively and postoperatively with a laser flare-cell meter (LFCM ; Kowa FM-500, Kowa Company Ltd, Tokyo, Japan).<br>|
| Relapse treated with silicone oil tamponade<br>Secondary vitrectomy and fluid-air exchange with silicone oil tamponade | Other: Aqueous flare measurement<br>* Aqueous flare was measured preoperatively and postoperatively with a laser flare-cell meter (LFCM ; Kowa FM-500, Kowa Company Ltd, Tokyo, Japan).<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in aqueous flare measurement (expressed as photon counts per millisecond and measured with a laser flare-cell meter) | Aqueous flare was measured preoperatively and postoperatively at 2 weeks, 4 weeks and 3 months with a laser flare-cell meter, in patients treated for RRD | preoperatively and postoperatively at 2 weeks and 3 months after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in aqueous flare measurement (measured with a laser flare-cell meter) | To describe the evolution of the aqueous humor flare between the postoperative visits at 2 weeks and at 3 months after retinal detachment surgery in each groups of patients. | postoperatively at 2 weeks and 3 months after surgery | 
| Comparison of aqueous flare values (measured with a laser flare-cell meter) between patients who relapsed and patients who didn't relapse | To compare the preoperative flare measurements between patients without versus with recurrence among those treated with gas | preoperative | 
| Evolution of measures of visual acuity | The best-corrected visual acuity (BCVA) was measured with projected-light Snellen charts and expressed in logMAR. | preoperatively and postoperatively at 3 months | 
| Evolution of macular status | Evaluation of macular status with macular imaging by optical coherence tomography (Heidelberg Engineering) | preoperatively and postoperatively at 3 months | 
| Relapsing status (yes or not) | Determined by careful fundus and peripheral retina examination. | at 3 months postoperative | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Aqueous Flare, Retinal Detachment