A Study to Compare Genetic Variations of IGF-I and IGF-II

Study Overview
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Brief Summary
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The purpose of this study is to determine if insulin-like growth factors (IGF) play a role in the development of dementia, specifically Alzheimer's disease (AD). The study will compare results from genetic testing between patients with AD and two other groups: younger biological family members of the AD patients and individuals without AD matched by age to the AD patients.

Official Title
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A Non-Randomized Controlled Cross-Sectional Study to Compare Genetic Variations of IGF-I and IGF-II in Patients With Moderate to Severe Dementia and Younger Family Members, in Relation to Age-Matched Unaffected Controls

Conditions
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Dementia

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Men and women between the ages of 50 and 81 years old who have a diagnosis of dementia Men and women who are at least 18 years old and are biologically related to the study subject with dementia Control subjects must not have a diagnosis of dementia and must be matched in age to the study subjects with dementia Exclusion Criteria: Biological family members of the dementia patient who are either younger than 17 years of age or older than the patient with dementia Biological family members with a diagnosis of dementia Age-matched control subjects with a diagnosis of dementia

Ages Eligible for Study
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Minimum Age: 50 Years
Maximum Age: 81 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Subjects with AD<br>Subjects with a diagnosis of dementia | |
| Family Members<br>Younger biological family members of the patients with dementia | |
| Control Group<br>Individuals without dementia matched in age to the patients with a dementia diagnosis | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Genetic polymorphisms of insulin-like growth factors | This study consists of a single clinic visit. After subject has completed the informed consent process and meets eligibility criteria, a blood sample and a saliva sample will be collected. Genetic results from this one-time specimen collection will be evaluated and compared with results from participants in the other two study groups. Outcomes will be measured comparatively. | Single clinic visit (day 1) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Genetic testing of Apolipoprotein (APO) E4 | This study consists of a single clinic visit. After subject has completed the informed consent process and meets eligibility criteria, a blood sample and a saliva sample will be collected. Genetic results from this one-time specimen collection will be evaluated and compared with results from participants in the other two study groups. Outcomes will be measured comparatively. | Single clinic visit (day 1) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Dementia, Insulin-like growth factor, IGF, APO E4, Genetics