Study to Investigate TIVA With Propofol on Postoperative Pain and Side Effects

Study Overview
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Brief Summary
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Propofol is a commonly used anaesthetic with rapid recovery and less side effects and total intravenous anaesthesia (TIVA) with propofol is a common technique now. The reduction on certain serum pro- inflammatory cytokines may lead to more smooth post- surgical recovery. Recent case report proved the analgesic effect of propofol infusion. However other animal and clinical studies showed controversial result. The aim of this retrospective study is to investigate the postoperative analgesic effects and side effects of intraoperative TIVA with propofol in patient undergoing surgery at Queen Mary Hospital, Hong Kong between 2014 to 2016.

Detailed Description
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Objectives: To investigate the analgesic effects of propofol. To evaluate the effect of propofol on postoperative adverse events. Methods: Retrospective audit. Data Collection: Demographic data; Types of analgesic techniques; Type of pain relief modalities; Pain score up to 72 hours postoperatively; Postoperative opioid consumption; Incidence of adverse events during APS care; Patients' satisfaction on pain relief.

Official Title
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Retrospective Study to Investigate Total Intravenous Anaesthesia (TIVA) With Propofol on Postoperative Pain and Side Effects After Surgery

Conditions
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Postoperative Pain

Intervention / Treatment
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* Drug: Propofol
* Procedure: general anaesthesia


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Anaesthetic records and acute pain service records of patient undergone surgery between 2014 to 2016 in Queen Mary Hospital would be retrieved from the computer. Exclusion Criteria: Essential data were missing. Patient participating in other research projects. Changes in postoperative pain management technique. Patients could not be assessed post-operatively for pain (i.e. post-operative IPPV)
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group TIVA<br>Patient undergoing surgery at Queen Mary Hospital, Hong Kong between 2014 to 2016 using intraoperative TIVA with propofol. | Drug: Propofol<br>* Patient undergoing surgery at Queen Mary Hospital, Hong Kong between 2014 to 2016 using intraoperative TIVA with propofol.<br>|
| Group GA<br>Patient undergoing surgery at Queen Mary Hospital, Hong Kong between 2014 to 2016 using general anaesthesia methods other than intraoperative TIVA with propofol. | Procedure: general anaesthesia<br>* Patient undergoing surgery at Queen Mary Hospital, Hong Kong between 2014 to 2016 using general anaesthesia methods other than intraoperative TIVA with propofol.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| pain score | pain score using numeral rating scale | up to postoperative day 3 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| analgesic consumption | analgesic consumption base on patient drug record | up to postoperative day 3 |