Effect of Non-surgical Periodontal Treatment on Cardiovascular Risk Markers

Study Overview
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Brief Summary
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The research question was to investigate whether non-surgical periodontal therapy could reduce cardiovascular risk markers in Coronary heart disease (CHD) patients.

Detailed Description
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CHD patients or non-CHD with or without periodontitis were included. They were provided with non-surgical periodontal therapy (NSPT). Periodontal parameters and cardiovascular risk markers were measured at baseline and 3 months and 6 months after NSPT.

Official Title
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Effect of Non-surgical Periodontal Treatment on Plasma Fibrinogen, Plasminogen Activator Inhibitor 1 and C-reactive Protein Levels in Cardiovascular Disease Patients With Periodontitis

Conditions
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Coronary Heart Disease, Periodontitis

Intervention / Treatment
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* Procedure: non-surgical periodontal treatment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: non-CHD or CHD (at least 50% diameter stenosis in at least one coronary artery and clinically stable with absence of any potentially confounding inflammatory conditions for at least 6 months) had at least 14 natural teeth excluding third molars Exclusion Criteria: received anticoagulant drugs had chronic conditions (e.g. diabetes mellitus, rheumatoid arthritis, malignancy, autoimmune disease) or acute conditions (e.g. trauma, surgery) or medications known to affect systemic inflammatory markers (e.g. antibiotics, immunosuppressive, contraceptives) within 3 months pregnancy or lactation presence or history of other infections periodontal treatment within 6 months tooth extractions within 2 months prior to the study.

Ages Eligible for Study
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Minimum Age: 35 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| coronary heart disease patients with periodontitis<br>Coronary heart disease patients confirmed through coronary angiography as having at least 50% diameter stenosis in at least one coronary artery and clinically stable with the absence of any potentially confounding inflammatory conditions for at least 6 months. Periodontitis classified as havingbleeding on probing (BOP), pocket depth (PD) > 4 mm, clinical attachment level (CAL) ≥ 5 mm and radiographic evidence of bone loss were presented at the same site of at least 4 teeth. | Procedure: non-surgical periodontal treatment<br>* scaling and root planing, home care instruction<br>|
| coronary heart disease patients without periodontitisHD<br>Coronary heart disease patients confirmed through coronary angiography as having at least 50% diameter stenosis in at least one coronary artery and clinically stable with the absence of any potentially confounding inflammatory conditions for at least 6 months. Non-periodontitis classified as having PD ≤ 3 mm. | Procedure: non-surgical periodontal treatment<br>* scaling and root planing, home care instruction<br>|
| non-coronary heart disease patients with periodontitis<br>Periodontitis classified as havingbleeding on probing (BOP), pocket depth (PD) > 4 mm, clinical attachment level (CAL) ≥ 5 mm and radiographic evidence of bone loss were presented at the same site of at least 4 teeth. | Procedure: non-surgical periodontal treatment<br>* scaling and root planing, home care instruction<br>|
| non-coronary heart disease patients without periodontitis<br>Non-periodontitis classified as having PD ≤ 3 mm. | Procedure: non-surgical periodontal treatment<br>* scaling and root planing, home care instruction<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change in fibrinogen level between baseline and 3 months after non-surgical periodontal treatment | change in plasma fibrinogen level (pg/mL) | 3 months after non-surgical periodontal treatment | 
| change in activator inhibitor 1 between baseline and 3 months after non-surgical periodontal treatment | change in activator inhibitor 1 level (pg/mL) | 3 months after non-surgical periodontal treatment | 
| change in C-reactive protein between baseline and 3 months after non-surgical periodontal treatment | change in C-reactive protein level (mg/L) | 3 months after non-surgical periodontal treatment | 
| change in fibrinogen level between baseline and 6 months after non-surgical periodontal treatment | change in plasma fibrinogen level (pg/mL) | 6 months after non-surgical periodontal treatment | 
| change in activator inhibitor 1 between baseline and 6 months after non-surgical periodontal treatment | change in activator inhibitor 1 level (pg/mL) | 6 months after non-surgical periodontal treatment | 
| change in C-reactive protein between baseline and 6 months after non-surgical periodontal treatment | change in C-reactive protein level (mg/L) | 6 months after non-surgical periodontal treatment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change of bleeding on probing between baseline and 3 months after non-surgical periodontal treatment | percetage of sites with bleeding on probing | 3 months after non-surgical periodontal treatment | 
| change of pocket depth between baseline and 3 months after non-surgical periodontal treatment | Depth of periodontal pocket in millimeters | 3 months after non-surgical periodontal treatment | 
| change of clinical attachment level between baseline and 3 months after non-surgical periodontal treatment | Level of clinical attachment in millimeters | 3 months after non-surgical periodontal treatment | 
| change of bleeding on probing between baseline and 6 months after non-surgical periodontal treatment | percetage of sites with bleeding on probing | 6 months after non-surgical periodontal treatment | 
| change of pocket depth between baseline and 6 months after non-surgical periodontal treatment | Depth of periodontal pocket in millimeters | 6 months after non-surgical periodontal treatment | 
| change of clinical attachment level between baseline and 6 months after non-surgical periodontal treatment | Level of clinical attachment in millimeters | 6 months after non-surgical periodontal treatment | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Coronary heart disease, peridontitis,