Joint Pain Occurring During Anti-TNF Therapy in Chronic Inflammatory Bowel Disease

Study Overview
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Brief Summary
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IBD (inflammatory bowel disease) are associated with various types of joint manifestations, especially inflammatory. Patients with IBD treated with anti-TNF commonly report joint symptoms, with variable expressions and aetiologies, possibly responsible for impaired quality of life, and possibly leading to discontinuation of an effective and validated treatment.

Official Title
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Joint Pain Occurring During Anti-TNF Therapy in Chronic Inflammatory Bowel Disease

Conditions
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Inflammatory Bowel Diseases

Intervention / Treatment
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* Other: diagnosis of joint


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Males or females over the age of 18 years at the time of inclusion Patients with IBD (Crohn's disease or ulcerative colitis), diagnosed by a set of compatible clinical (chronic diarrhoea, haematochezia, anoperineal lesions, etc.), laboratory, histological and endoscopic arguments. Patients will be included regardless of the severity of their disease, its clinical course, the type of lesions, and the presence or absence of associated manifestations. Patients treated with anti-TNF: infliximab or adalimumab. Informed patients not refusing to participate. Patients covered by French national health insurance. Exclusion Criteria: Patients under the age of 18 years at the time of inclusion. Patients previously treated with anti-TNF, but no longer treated with anti-TNF at the time of inclusion. Protected majors (under permanent or temporary guardianship).

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Control<br>patients treated with anti-TNF not presenting any joint symptoms. | Other: diagnosis of joint<br>* The diagnosis of joint pain will be established by a rheumatologist and completed: If necessary, by a clinically guided radiological assessment (plain x-rays, joint ultrasound, bone and joint MRI). serum assays of the anti-TNF administered, as well as screening for associated antibodies.<br>|
| case<br>aetiology of joint symptoms | Other: diagnosis of joint<br>* The diagnosis of joint pain will be established by a rheumatologist and completed: If necessary, by a clinically guided radiological assessment (plain x-rays, joint ultrasound, bone and joint MRI). serum assays of the anti-TNF administered, as well as screening for associated antibodies.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diagnosis of joint pain | presence or absence : The diagnosis of joint pain will be established by a rheumatologist and completed: If necessary, by a clinically guided radiological assessment (plain x-rays, joint ultrasound, bone and joint MRI). serum assays of the anti-TNF administered, as well as screening for associated antibodies. | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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joint pain