Evaluation of HbA1c Levels and Ovarian Reserve and Type 1 Diabetes

Study Overview
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Brief Summary
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The human ovary is the target of an autoimmune attack, usually in organ or non-specific autoimmune disorders. Serum anti-Müllerian hormone (AMH) levels decrease early in menopause and menopause is seen in women with type 1 diabetes mellitus (DM1) at a young age. DM1 is aimed to show DM1 relationship with ovarian reserve based on the assumption that it will have lower AMH levels than controls, secondary to bad glycemic control and autoimmune attack in women.

Detailed Description
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The study was designed prospectively. Ovarian functions in healthy volunteer women and patients who use DM1 diagnosed between 18-40 years old will be examined. Gonadotropin and AMH levels will be measured in follicular phase. To calculate the number of antral follicles (AFC) and ovarian volume, ultrasound will be looked at. Fasting and satiety blood glucose, HbA1c and C-peptide levels will be evaluated.

Official Title
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Evaluation of HbA1c Levels and Ovarian Reserve in Patients With Type 1 Diabetes Diagnosis

Conditions
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Diabetes, Ovarian Failure

Intervention / Treatment
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* Diagnostic Test: ovarian reserve


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: female patients between 18 and 40 years of age who had consent and had gynecological examination in our polyclinic; study group for patients with type 1 diabetes mellitus healthy volunteers control group Exclusion Criteria: Other endocrine and / or autoimmune disorders, polycystic ovary syndrome (PCOS) and previous surgery, which may reduce ovarian reserves; medical and / or radiotherapy

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group 1 diagnosed with Diabetes Mellitus<br>Patients with Type 1 Diabetes Mellitus aged 18-40 years who had ovarian reserve with gynecological examination | Diagnostic Test: ovarian reserve<br>* To assess ovarian reserve in patients with Type 1 Diabetes Mellitus aged 18-40 years; ultrasonographic and laboratory parameters will be looked at.<br>|
| group 2 control group<br>Healthy volunteer patients aged 18-40 years who have no diagnosis of Type 1 Diabetes Mellitus and whose ovarian reserve is evaluated by gynecological examination | Diagnostic Test: ovarian reserve<br>* To assess ovarian reserve in patients with Type 1 Diabetes Mellitus aged 18-40 years; ultrasonographic and laboratory parameters will be looked at.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Antral follicle count (AFC) | AFC was calculated by counting 2-10 mm diameter follicles in both ovaries with a standard systematic approach.Recorded as a number. | On the 3rd day of the menstrual cycle | 
| Anti müllerian hormone (AMH) | AMH concentrations were measured by an enzymatically enhanced bilaterally immunoassay. AMH (pmol / l) saved as. | On the 3rd day of the menstrual cycle | 
| HbA1c | HBA1C concentrations were measured by taking venous blood samples in the early morning hours. HBA1C (mmol / mol) saved as. | On the 3rd day of the menstrual cycle | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Antral follicle count, Anti müllerian hormone, Ovarian reserve, HbA1c, type 1 diabetes mellitus