Meta-Analysis Accidental Hypothermia in Trauma

Study Overview
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Brief Summary
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This is a systematic literature review and meta-analysis investigating the effect of accidental hypothermia on mortality in trauma patients overall and patients with TBI specifically. Literature search will be performed using the Ovid Medline/PubMed database. Studies comparing the effect of hypothermia vs. normothermia at hospital admission on in-hospital mortality will be included in meta-analysis.

Detailed Description
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Accidental hypothermia is a known predictor for worse outcomes in trauma patients, but has not been comprehensively assessed in meta-analysis so far. The aim of this systematic review and meta-analysis is to investigate the impact of accidental hypothermia on mortality in trauma patients overall and patients with traumatic brain injury (TBI) specifically. Literature search will be conducted using the Ovid Medline/PubMed database. The search strategy will be based on the PICOS strategy. Scientific articles reporting (1) accidental hypothermia in trauma patients overall or patients with TBI specifically, (2) body temperature and time of measurement, and (3) the impact of accidental hypothermia on outcomes will be included in the qualitative review. Two meta-analyses will be performed including (1) trauma patients overall and (2) patients with TBI specifically. Studies reporting in-hospital mortality of hypothermic and normothermic trauma patients overall or patients with TBI specifically, based on the temperature measured at Emergency Department admission, will be included in meta-analysis. Meta-analysis will be performed using a Mantel-Haenszel random-effects model. The estimated effect size for mortality will be reported as odds ratio (OR) and 95% confidence interval (CI) for each study as well as for the overall cohort.

Official Title
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The Impact of Accidental Hypothermia on Mortality in Trauma Patients Overall and Patients With Traumatic Brain Injury Specifically: A Systematic Review and Meta-Analysis

Conditions
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Hypothermia, Trauma, Brain Injuries, Traumatic, Morality

Participation Criteria
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Eligibility Criteria
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Inclusion criteria: Original scientific articles English language Study in trauma patients Reported body temperature and time of temperature measurement Reported impact of accidental hypothermia on outcomes Exclusion criteria: Case reports Systematic reviews Articles on therapeutic hypothermia
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Hypothermia group<br>Hypothermic trauma patients or hypothermic patients with traumatic brain injury specifically. | |
| Normothermia group<br>Normothermic trauma patients or normothermic patients with traumatic brain injury specifically. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| In-hospital mortality | Death occurring during the hospital stay | From hospital admission to discharge, expected to be up to 4 weeks |