Satiety Response of Short Chain Fructooligosaccharide

Study Overview
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Brief Summary
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Populations that report high fiber consumption demonstrate lower rates of obesity. Enhanced satiety may play a key role in this relationship. The colonic fermentation of fibers is theorized to influence satiety and food intake. Short chain fructooligosaccharide (scFOS) are rapidly fermentable fibers that can easily be added to foods to impact these parameters. The objective of this study was to evaluate the satiety response of scFOS and its ability to decrease food intake.

Detailed Description
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Intervention study with fiber added to beverages and acute effects on satiety measured.

Official Title
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Satiety Response of Short Chain Fructooligosaccharide

Conditions
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Healthy

Intervention / Treatment
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* Dietary Supplement: Short chain fructo-oligosaccharide (scFOS) 5 g
* Other: Placebo
* Dietary Supplement: Short chain fructooligosaccharide (scFOS) 8 g


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy men and women Age 18-64 years Non-smoking Not taking medication Non-dieting (weight stable in prior 3 months) BMI 18-27 English literacy Exclusion Criteria: Do not regularly consume breakfast Food allergies to ingredients found in study products BMI <18 or >27 Diagnosed cardiovascular, renal, or hepatic disease diabetes mellitus Cancer in previous 5 years (except basal cell carcinoma of the skin) Any gastrointestinal disease or condition Recent bacterial infection (< 3 months) Recent or concurrent participation in an intervention research study History of drug or alcohol abuse in prior 6 months Use of lipid-lowering, anti-hypertensive, or anti-inflammatory steroid medication Eating disorder Vegetarians People who eat more than approximately 15 grams of fiber per day Women who are pregnant or lactating Women with irregular menstrual cycles

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 64 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Placebo<br>No treatment | Other: Placebo<br>* Treatment without scFOS fiber<br>|
| Experimental: scFOS 5 g<br>5 g scFOS | Dietary Supplement: Short chain fructo-oligosaccharide (scFOS) 5 g<br>* Dietary Supplement: scFOS 5 g Novel fiber administered in two 5 g doses--the first in a beverage and the second in a solid chew.<br>* Other names: fructo-oligosaccharide;|
| Experimental: scFOS 8 g<br>8 g scFOS | Dietary Supplement: Short chain fructooligosaccharide (scFOS) 8 g<br>* Novel fiber administered in two 8 g doses--the first in a beverage and the second in a solid chew.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Satiety response using visual analogue scales | Satiety response was measured using subjective perceptions of hunger, fullness, satisfaction, and prospective food intake evaluated by previously validated visual analogue scales (VAS). | 0, 15, 30, 45, 60, 90, 120, 180, 240 minutes postprandially | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ad libitum food intake |  | 240 minutes postprandially and over 24 hours | 
| Breath hydrogen response |  | 0, 240 minutes | 
| Gastrointestinal tolerance using visual analogue scales (VAS) | Subjective ratings of bloating, stool consistency, and flatulence on VAS. A stool count was also recorded. | 24 hours |