Preterm Infants' Weight Gain Following Massage Therapy

Study Overview
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Brief Summary
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The specific aims of this study are: 1) to replicate the data that following ten days of massage therapy, preterm infants show greater daily weight gain and are discharged from the hospital earlier than the controls, thus demonstrating the cost-effectiveness of the intervention; 2) to test a model on two potential underlying mechanisms for weight gain including a) enhanced vagal activity leading to greater gastric motility, higher levels of insulin, IGF-1, and oxytocin and lower cortisol levels in the massage versus the control infants at the end of the study; and/or b) increased physical activity and its associated increase in heart rate oxygen consumption and temperature leading to greater weight gain. These pathways (vagal activity and physical activity) will be tested by path analyses. Determining underlying mechanisms for the massage therapy/weight gain relationship is a critical process required by the neonatology community for massage therapy to be adopted as a standard neonatal intensive care unit.

Detailed Description
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A number of studies have documented an average of 47% greater weight gain in preterm neonates following massage therapy. Our currently funded study suggests that massage therapy increases vagal activity, oxytocin, and IGF-1. In the proposed continuation of this study preemies would be provided daily massages three times a day for 10 days, as in our previously successful protocol. To determine potential mechanisms that may underlie the massage therapy/weight gain relationship we will continue to assess vagal activity and assay insulin, oxytocin, IGF-1 and cortisol as well as gastric motility. We have added an alternative potential pathway for the massage therapy/weight gain relationship. In this expanded model, activity level and the related measures of heart rate, oxygen consumption (based on a formula calculated from heart rate) and temperature mediate the effects of massage therapy on weight gain. A larger sample will be recruited so that we can have the power needed to test our model of the potential mechanisms underlying the weight gain from preterm infant massage. For the current application, 120 preterm infants with common medical complications of prematurity, who are medically stable and residing in the intermediate care (grower) nursery, will be assigned to groups based on a random stratification on the following variables: gender, gestational age, birthweight, days in the NICU, and study entry weight. One hundred twenty infants will be randomly assigned to one of two groups: 1) ten days of massage therapy (n=60), or 2) standard treatment (n=60). Within-subjects and between-groups analyses will focus on physiological (heart rate, vagal tone, gastric motility, and temperature), biochemical (insulin, oxytocin, IGF-1 and cortisol) and behavioral variables (activity level).

Official Title
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Preterm Infants' Weight Gain Following Massage Therapy

Conditions
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Premature Birth

Intervention / Treatment
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* Procedure: massage
* Procedure: Sham massage


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Gestational age between 28 and 32 weeks Birthweight between 800 and 1,400 grams Birthweight, length, and head circumference appropriate for gestational age Scores on the Obstetric/Postnatal Complications scales are each below 80 NICU stay between 15 and 60 days Current weight between 1,000 and 1,500 grams Current daily intake is between 120 and 160 calories Exclusion Criteria: Genetic anomalies, congenital heart malformations, and/or central nervous system dysfunction HIV infection History of maternal alcohol or illicit drug use Syphilis Hepatitis B Require surgery

Ages Eligible for Study
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Minimum Age: 28 Weeks
Maximum Age: 32 Weeks

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>15 minute massage tid | Procedure: massage<br>* 15 massage given tid<br>|
| Sham Comparator: 2<br>non-massage touch | Procedure: Sham massage<br>* non-massage touch<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| weight gain |  | post-massage | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Massage Therapy, Preterm Infants, Weight Gain, Vagal Tone, IGF-1, Oxytocin, Brazelton