Febuxostat for Tumor Lysis Syndrome Prevention in Hematologic Malignancies

Study Overview
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Brief Summary
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The purpose of this study is to determine whether febuxostat is superior to allopurinol in the prevention of tumor lysis syndrome (TLS) in patients with hematological malignancies at intermediate or high risk of TLS (according to Cairo-Bishop classification) who undergo chemotherapy

Detailed Description
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This study is designed as a randomised, double-blind, active-controlled, parallel-group study to be conducted in approximately 80 sites. Approximately 340 male or female patients aged 18 or older suffering from hematologic malignancies (de novo patients or relapsing patients) at intermediate to high risk of TLS and scheduled for receiving the first cycle of cytotoxic chemotherapy, regardless of the line of treatment, will be randomized in this study. Eligible patients (as per screening visit) will be randomly allocated in a 1:1 ratio to Febuxostat or Allopurinol. The double-blind treatment period starts two days prior to the planned beginning of chemotherapy and continues for 7 to 9 consecutive days, according to Investigator judgment and on the basis of the actual duration of chemotherapy regimen administered to the patient. Along the study treatment, uric acid levels, creatinine levels, Laboratory TLS/Clinical TLS and Adverse Events represent the major clinical findings to be monitored on a daily basis. Overall the study encompasses 10 to 11 planned visits at site, including screening, randomisation, on treatment and final follow up visits.

Official Title
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Febuxostat for Tumor Lysis Syndrome Prevention in Hematologic Malignancies: a Randomized, Double Blind, Phase III Study Versus Allopurinol

Conditions
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Tumor Lysis Syndrome

Intervention / Treatment
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* Drug: Febuxostat
* Drug: Allopurinol


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients scheduled for first cytotoxic chemotherapy cycle, regardless of the line of treatment, because of hematologic malignancies at intermediate or high risk of TLS (according to the TLS risk stratification, Cairo M et al, British Journal of Haematology, 2010)candidate to Allopurinol treatment or have no access to Rasburicase Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 3 Life expectancy > 1 month Exclusion Criteria: Patients known to be hypersensitive to Febuxostat or Allopurinol or to any of the components of the formulations Patients with sUA levels ≥ 10 mg/dL at randomization Patients receiving Febuxostat, Allopurinol or any other urate lowering therapy (e.g. Rasburicase, probenecid) within 30 days prior to randomization Patients with severe renal and/or hepatic insufficiency Patients with diagnosis of LTLS or CTLS at randomization

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Febuxostat<br>Febuxostat for 7-9 days | Drug: Febuxostat<br>* Standard dose PO (per os) from Day 1 to Day 7 (can be continued up to DAY 9 at investigator's discretion)<br>* Other names: Adenuric;|
| Active Comparator: Allopurinol<br>Allopurinol for 7-9 days | Drug: Allopurinol<br>* Standard dose, low dose or high dose (as per investigator's judgement at the time of randomization) from DAY 1 to DAY 7 (can be continued up to DAY 9 at investigator's discretion)<br>* Other names: Zyloric;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Serum Uric Acid (sUA) Level Control | Area under the curve of sUA from baseline (Day 1) to the evaluation visit (Day 8) | 8 days | 
| Preservation of Renal Function | Change in serum creatinine level from baseline (Day 1) to the evaluation visit (Day 8) | 8 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Treatment Responder Rate | Assessment of treatment responder rate, where treatment response is defined as the maintenance of sUA ≤ 7.5 mg/dL from Day 3 to Day 8 | 6 days | 
| Assessment of Laboratory Tumor Lysis Syndrome (LTLS) | Assessment of LTLS, from Day 3 to Day 8. According to Cairo-Bishop definition LTLS is defined by the presence of 2 or more laboratory abnormalities including: a 25% increase or levels above normal for serum uric acid, potassium, and phosphate or a 25% decrease or levels below normal for calcium. | 6 days | 
| Assessment of Clinical Tumor Lysis Syndrome (CTLS) | Assessment of CTLS, from Day 3 to Day 8. According to Cairo-Bishop definition, CTLS is defined by the presence of LTLS in addition to 1 or more of the following significant clinical complications: renal insufficiency, cardiac arrhythmias, sudden death and seizures. The grade of CTLS is defined by the maximal grade of the clinical manifestation | 6 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Febuxostat, Tumor lysis syndrome, leukemia, lymphoma