Hepatitis C Infection in World Trade Center Responders

Study Overview
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Brief Summary
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This study provides Hepatitis C virus screening to the members of the World Trade Center Health Program followed at the Icahn School of Medicine at Mount Sinai born during 1945-1965, and linkage to care for those found infected. The study will also determine if exposure to human remains, blood and/or bodily fluids during the World Trade Center Health Program activities are associated with Hepatitis C virus infection. These findings would be relevant to the larger United States population, especially to persons born during 1945-1965 who are at high risk of Hepatitis C virus infection.

Detailed Description
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The purpose of the project is to determine if the World Trade Center Health Program cohort is at an increased risk of Hepatitis C virus infection, determine if human exposure to human remains, blood and/or body fluids during the World Trade Center recovery activities is associated with increased risk of Hepatitis C virus infection, and to determine if referral to a co-located site for Hepatitis C virus care is associated with improved linkage to Hepatitis C virus care in the members of the World Trade Center Health Program born during 1945 through 1965.

Official Title
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Hepatitis C Infection in World Trade Center Responders

Conditions
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Hepatitis C Infection

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Member of the World Trade Center Health Program at the Icahn School of Medicine at Mount Sinai Born during 1945-1965 Exclusion Criteria: None

Ages Eligible for Study
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Minimum Age: 51 Years
Maximum Age: 72 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| WTC responders participating in HCV infection study<br>Members of the World Trade Center Health Program cohort born from 1945 to 1965 who choose to participate in this research study on hepatitis C infection | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prevalence of Hepatitis C virus infection | The investigator will measure the prevalence of Hepatitis C virus infection in 3900 World Trade Center Health program members to test the hypothesis that World Trade Center Health program members have an increased risk of Hepatitis C virus infection. | 2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between the exposure to human remains, blood and/or bodily fluids to hepatitis C virus infection. | The investigator will test the measure of association between exposure to human remains, blood and / or bodily fluids and risk of hepatitis C virus infection, while adjusting for type of activity during work at World Trade Center site and use of personal protective equipment. | 2 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Baby Boomer, hepatitis C virus, linkage-to-care, World Trade Center Health Program cohort, risk factors for hepatitis C virus infection