Changes in Invitro and ex Vivo Lens Metrology With Daily Wear Contact Lenses

Study Overview
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Brief Summary
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The purpose of this study is to evaluate changes in contact lens geometry after lens wear

Detailed Description
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The purpose of this study is to evaluate changes invitro and ex vivo in contact lens geometry in daily lens wear

Official Title
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Changes in Invitro and ex Vivo Lens Metrology With Experienced Daily Wear Contact Lens Wearers

Conditions
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Myopia

Intervention / Treatment
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* Device: Air Optix Aqua
* Device: Biofinity
* Device: Proclear
* Device: Acuvue Oasys
* Device: Acuvue 2
* Device: Purevision


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: • Able to read and comprehend English and give informed consent as demonstrated by signing a record of informed consent; Be at least 18 years old; Willing to comply with the wearing and clinical trial visit schedule as directed by the investigator; Have ocular health findings considered to be normal and which would not prevent the participant from safely wearing contact lenses; Has vision correctable to at least 6/12 (20/40) or better at distance in each eye with contact lenses; Be experienced at wearing contact lenses. Exclusion Criteria: • Any pre-existing ocular irritation, injury or condition (including keratoconus and herpes keratitis) of the cornea, conjunctiva or eyelids that would preclude contact lens fitting and safe wearing of contact lenses; Any systemic disease that adversely affects ocular health An active corneal infection or any active ocular disease that would affect wearing of contact lenses; Use of any topical ocular medication during trial with the exception of saline drops ; Use of or a need for any systemic medication or topical medications which may alter normal ocular findings/are known to affect a participant's ocular health/physiology or contact lens performance Eye surgery within 12 weeks immediately prior to enrolment for this trial; Previous corneal refractive surgery; Contraindications to contact lens wear; Participated or currently enrolled in another clinical trial that may have affected vision or ocular physiology within the previous 2 weeks; Be pregnant (formal testing of pregnancy is not required. A participant's verbal report is sufficient); Worn soft contact lenses 2 calendar days or rigid gas permeable/ orthokeratology lenses 7 calendar days prior.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Air Optix Aqua<br>Contact lens material: Lotrafilcon A | Device: Air Optix Aqua<br>* Contact lens material: Lotrafilcon A<br>* Other names: Air Optix;|
| Active Comparator: Biofinity<br>Contact lens material: Comfilcon A | Device: Biofinity<br>* Contact lens material: Comfilcon A<br>* Other names: CV Biofininty;|
| Active Comparator: Proclear<br>Contact lens material: Omafilcon A | Device: Proclear<br>* Contact lens material: Omafilcon A<br>* Other names: Proclear Compatibles;|
| Active Comparator: Acuvue Oasys<br>Contact lens material: Senofilcon A | Device: Acuvue Oasys<br>* Contact lens material: Senofilcon A<br>* Other names: Oasys;|
| Active Comparator: Acuvue 2<br>Contact lens material: Etafilcon A | Device: Acuvue 2<br>* Contact lens material: Etafilcon A<br>* Other names: AV 2;|
| Active Comparator: Purevision<br>Contact lens material: Balafilcon A | Device: Purevision<br>* Contact lens material: Balafilcon A<br>* Other names: PV;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Lens Geometry |  | 1 week | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Corneal Shape |  | 1 week | 
| Conjunctival Staining | The conjunctival staining | 1 week | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Contact lenses, myopia, lens geometry