The Usefulness of Postprandial Triglyceride for Assessment of Cardiovascular Risk

Study Overview
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Brief Summary
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The hypertriglyceridemia at fasting status has been known to be an important risk factor for cardiovascular disease (CVD). Recently, postprandial triglyceride (TG) levels draw an attention as a superior predictor of CVD because of non-fasting state for more than 12 hours and importance of triglyceride-rich lipoprotein. We aim to investigate the relationship of postprandial triglyceride after fat tolerance test and intima-medial thickness and to suggest normal reference of postprandial triglyceride after fat tolerance test. In addition, we evaluate the correlation of postprandial triglyceride and incretin secretion after fat tolerance test Ultimately, we want to estimate clinical importance of postprandial triglyceride in assessment of cardiovascular risk.

Official Title
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The Usefulness of Postprandial Triglyceride for Assessment of Cardiovascular Risk in Healthy People, Impaired Glucose Tolerance and Type 2 Diabetes

Conditions
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Diabetes, Prediabetes

Intervention / Treatment
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* Dietary Supplement: Oral fat tolerance test


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age : 19   70 yrs Type 2 diabetes : HbA1c <10% Prediabetic state : HbA1c 5.7 6.4% Exclusion Criteria: Type 1 diabetes, secondary diabetes dipeptidyl peptidase-4 -inhibitor, glucagon-like peptide-1 agonist, thiazolidinediones users Thyroid disease with abnormal thyroid function test Liver disease with abnormal liver function test severe kidney disease pregnant or lactating women current smoker severe obesity

Ages Eligible for Study
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Minimum Age: 19 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Screening
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Type 2 DM<br>Intervention : Oral fat tolerance test well or moderately controlled type 2 diabetes mellitus (HbA1c < 10%) No dipeptidyl peptidase-4 -inhibitor, Glucagon-like peptide-1 agonist, thiazolidinediones | Dietary Supplement: Oral fat tolerance test<br> <br> |
| Active Comparator: Prediabetes<br>Intervention : Oral fat tolerance test Glucose 140-199 mg/dL after 75g oral glucose tolerance test HbA1c 5.7-6.4% | Dietary Supplement: Oral fat tolerance test<br> <br> |
| Sham Comparator: Normal glucose tolerance<br>Intervention : Oral fat tolerance test No impaired fasting glucose and impaired glucose tolerance | Dietary Supplement: Oral fat tolerance test<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes of Triglyceride | Blood sample : drawn by a catheter before the meal and every 1 hour after meal over the 8-hour period | 8 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes of incretin |  | 8 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Postprandial period, triglyceride, Diabetes mellitus, type 2, Prediabetic state