Blood Pressure Variability and the Prognosis of Ischemic Stroke With Intracranial Artery Stenosis

Study Overview
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Brief Summary
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Correlation study about Blood Pressure Variability and the prognosis of ischemic stroke with intracranial artery stenosis

Detailed Description
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Extracranial atherosclerotic stenosis is the main reason for the European and American white ischemic stroke and transient ischemic attack,while Atherosclerotic intracranial arterial stenosis is an important reason for Asian patients with stroke ,accounting for the 33% to 51% of a etiology ratio.The latest research suggests that varying degrees of blood pressure variability can affect the risk of stroke.This study observe the relationship between blood pressure variability and prognosis of ischemic stroke patients with intracranial arterial stenosis,with cranial magnetic resonance imaging (MRI + DWI),magnetic resonance angiography and Trans-cranial Doppler(TCD) .

Official Title
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The Correlation Study Between Blood Pressure Variability and the Prognosis of Ischemic Stroke With Intracranial Artery Stenosis

Conditions
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Blood Pressure Variability, Intracranial Artery Stenosis

Intervention / Treatment
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* Drug: Amlodipine
* Drug: ACEI / ARB
* Drug: Aspirin or Clopidogrel
* Drug: Atorvastatin


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age : ≥ 18 years of age , ≤ 75 years old with intracranial artery stenosis in ischemic stroke the diagnosis of ischemic cerebrovascular disease are in line with the diagnostic criteria developed by the Chinese Medical Association Fourth National Cerebrovascular Disease Conference the patient admitted to hospital receive at least one examination like cranial MRI + DWI, MRA and TCD examination, clearly associated with intracranial arterial stenosis MRS score ≤ 3 points Exclusion Criteria: vascular , cardiac , and unknown causes or other reasons lead to ischemic stroke associated with significant emotional disorders, cognitive impairment or other mental disorders can not be partners severe occlusion of Unilateral intracranial arteries ( over 90 % ) or bilateral stenosis more than 70% With extracranial artery stenosis, especially carotid and vertebral artery stenosis . patients with extracranial artery stenosis or patients previously done neck or intracranial artery balloon dilation , stent forming surgery or carotid endarterectomy Incomplete clinical data collection in patients

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: amlodipine<br>The amlodipine - based antihypertensive treatment group (you can add a diuretic or other ) | Drug: Amlodipine<br>* The amlodipine - based antihypertensive treatment group (you can add a diuretic or other )<br>Drug: Aspirin or Clopidogrel<br>* aspirin 100mg / d or Clopidogrel 75mg / d (anti-platelet agents)<br>Drug: Atorvastatin<br>* Atorvastatin 10 - 40mg / d ( statin therapy)<br>|
| Experimental: ACEI / ARB<br>ACEI / ARB -based antihypertensive treatment group ( you can add the B - blockers or other) | Drug: ACEI / ARB<br>* ACEI / ARB -based antihypertensive treatment group ( you can add the B - blockers or other)<br>Drug: Aspirin or Clopidogrel<br>* aspirin 100mg / d or Clopidogrel 75mg / d (anti-platelet agents)<br>Drug: Atorvastatin<br>* Atorvastatin 10 - 40mg / d ( statin therapy)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the incidence of stroke in a follow-up period |  | one year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| blood pressure during the compliance status in a follow-up |  | one year | 
| patients with blood pressure variability in a follow-up |  | one year | 
| Changes in intracranial arterial stenosis and stiffness before and after the follow-up |  | one year | 
| Other vascular events ( acute ischemic heart disease or vascular death ) |  | one year |