Treatment Decision-making in Patients With Recurrent High-grade Glioma

Study Overview
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Brief Summary
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This qualitative study explores the lived experience of high-grade glioma patients and their close relatives at time of recurrence. With focus on the decision-making about treatment and care..

Detailed Description
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High-Grade Glioma is a life-threatening disease that can cause the patient substantial physical, mentally and psychosocially impairment. The life expectancy is short, and a majority of patients experience recurrence of tumour growth. At time of recurrence, the treatment possibilities can include surgery, oncological treatment and/or palliative care. In this situation the patients and their close relatives need to make a difficult balancing between benefits and trade offs. Little is known about how the patients and their close relatives experience the recurrence and the decision-making process. The objective of this study is therefore to explore the perspectives, experiences and needs in patients and their close relatives in relation to the decision-making process at time of recurrence. Data will be generated through semi-structured interviews. Interviews will be analysed and interpreted using a Ricoeur inspired method of qualitative analysis. The study is part of a larger PhD-study.

Official Title
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Recurrent High-grade Glioma: Experiences of Patients and Their Close Relatives During the Treatment Decision-making Process.

Conditions
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Malignant Glioma, Life Experiences

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: The patient is offered surgical treatment (after an assesment done by the multidisciplinary team) Able to speak and understand danish Able to participate in an interview Able to give informed concent for participation Exclusion Criteria: Patients with severe cognitive impairment which prohibits them from either giving informed concent or participating in interview. Relatives are excluded if the patient do not give concent for the participation of relatives

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients<br>Patients with recurrent high-grade glioma | |
| Relatives<br>Close relatives of patients with recurrent high-grade glioma | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Experiences of patients and relatives | How patients and their close relatives experience the decision-making process | Interviews are performed 2-6 weeks after the decision-making | 
| Involvement preferences | The preferences of patients and relatives for being involved in the decision-making. | Interviews are performed 2-6 weeks after the decision-making | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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High-grade glioma, Patient experiences, Decision-making, Patient involvement