linjc16/ctgov huggingface dataset:
Effect of an Electronic Cognitive Aid Versus Static Cognitive Aid on the Management of a Simulated Crisis

Study Overview
=================
Brief Summary
-----------------
Clinical decision support tools with in the electronic medical record can improve clinical care processes. To date, there is little evidence evaluating crisis management with such decision support tools. The investigators aim to create an electronic cognitive aid with embedded decision support to aid clinicians during the management of a crisis. In order to test the effectiveness of this tool, investigators seek to compare the simulated medical management of a crisis (malignant hyperthermia) using a traditional cognitive aid (laminated card) versus a dynamic electronic visual aid with decision support.

Official Title
-----------------
The Effect of an Electronic Dynamic Cognitive Aid Versus a Static Cognitive Aid on the Management of a Simulated Crisis

Conditions
-----------------
Cognitive Aids

Intervention / Treatment
-----------------
* Other: Electronic Cognitive Aid
* Other: Static Cognitive Aid


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: resident physicians training in Anesthesia Exclusion Criteria: Non resident anesthesia providers
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Electronic aid<br>The dynamic aid will consist of a centralized electronic aid embedded within a simulated EMR. | Other: Electronic Cognitive Aid<br> <br> |
| Active Comparator: Static Cognitive aid<br>The static aid represents the standard algorithm put forth by a leading clinical care organization. | Other: Static Cognitive Aid<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Performance on Task Checklist | Number of tasks successfully performed as rated on video review | Time 0-30min | 
| Anesthesia Nontechnical skills score | Overall performance score; Video of management of crisis will be reviewed after completion of the scenario. | Time0-30min | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Randomization, cognitive aids types, aids
Cardiac, Pulmonary and Diaphragm Sonography for the Early Diagnosis of the Different Etiologies Underlying Failure of Weaning From Mechanical Ventilation

Study Overview
=================
Brief Summary
-----------------
Weaning patients off ventilation in an ICU is sometimes difficult, because of three major inter-related etiologies: impaired lung, heart and diaphragm function. In this context, ultrasonography during tests to wean patients off ventilation could make it possible to diagnose cardiac dysfunction, a loss of pulmonary aeration or diaphragm dysfunction and thus reduce the number of failures at extubation. The study will be carried out in 100 patients on mechanical ventilation following abdominal or heart surgery, who will have echocardiography, and pulmonary and diaphragm ultrasonography.

Official Title
-----------------
Combined Cardiac, Pulmonary and Diaphragm Sonography for the Evaluation of Failure in Ventilation Weaning

Conditions
-----------------
Mechanical Ventilation, Following Heart or Abdominal Surgery

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients on mechanical ventilation for at least 48 hours Age ≥ 60 years Patients who have undergone abdominal or heart surgery Exclusion Criteria: Patients with a known neuromuscular disease Patients younger than 60 years Duration of mechanical ventilation <48h Non-surgical patients Patients with severe COPD

Ages Eligible for Study
-----------------
Minimum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Echocardiography |  | At baseline | 
| Lung ultrasonography |  | At baseline | 
| Diaphragm ultrasonography |  | At baseline |
Comparison Between Two Endoscopic Treatments of Bleeding Internal Hemorrhoids:Band Ligation and Electrocoagulation Probe

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine which treatment, band ligation (placing rubber bands around the hemorrhoids) or BICAP electrocoagulation (using electricity to cauterize) is safer and more effective endoscopic treatment for bleeding internal hemorrhoids.

Official Title
-----------------
Randomized Study Of Endoscopic Band Ligation Versus Bipolar Probe Electrocoagulation Of Bleeding Internal Hemorrhoids

Conditions
-----------------
Hemorrhoids

Intervention / Treatment
-----------------
* Procedure: Rubber band ligation
* Procedure: Bipolar coagulation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Grade II or III internal hemorrhoids with chronic rectal bleeding, which failed at least 8 weeks of intensive medical therapy. Age over 18 years A life expectancy of at least 24 months A signed written informed consent Exclusion Criteria: The patient was uncooperative or could not return for routine outpatient follow-up Severe or end-stage co-morbid illness Prior endoscopic or surgical treatment of hemorrhoids within the past 6 months Ongoing need for anticoagulation therapy or high doses of aspirin or non-steroidal antiinflammatory agents Presence of severe rectal pain Recently thrombosed internal or external hemorrhoids Anal stricture,fissure, fistula,or abscess Rectal carcinoma or bleeding distal colonic polyp Rectal varices Acute or chronic colitis Rectal prolapse Radiation telangiectasia of the rectum Prothrombin time >3 seconds over control Platelet count <75,000

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: 1<br>Rubber band ligation | Procedure: Rubber band ligation<br>* placing rubber bands around the internal hemorrhoids<br>|
| Active Comparator: 2<br>Bipolar coagulation | Procedure: Bipolar coagulation<br>* using electricity to cauterize<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| treatment success rate |  | one year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| treatment complication rate |  | one year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Internal hemorrhoids, Rubber band ligation, Bipolar coagulation
Epidemiological Profile of Ophthalmological Care in the Public Service in Brazil

Study Overview
=================
Brief Summary
-----------------
Epidemiological study about eye discomfort complaints, comorbidities and diagnosis at a Brazil's ophthalmological public care service

Detailed Description
-----------------
1670 individuals underwent an ophthalmologic evaluation The data were obtained through the analysis of the medical records with the ICD-10 registration The studied variables were age and sex of patient, origin, eye discomfort complaints, comorbidities and diagnosis (ICD-10). The purpose was to evaluate epidemiological aspects of eye diseases in a public service

Official Title
-----------------
Epidemiological Profile of Ophthalmological Care in the Public Service in Brazil

Conditions
-----------------
Eye Abnormalities

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients assisted in public service Exclusion Criteria:
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Ocular diseases<br>Observational | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence and prevalence of visual conditions in the Public Service in Brazil | The ages ranged from 0 to 99 years The mean age was 56.9 years There was a predominance of females (58.1%) The main reason for the consultation was low visual acuity (70%), followed by burning (26%) and itchiness (24.4%) Among the abnormal tests there was a high prevalence of refractive errors (73.4%) and presbyopia (59.6%) The cause of refractive errors was astigmatism (70.5%), hypertrophy (58.6%) and myopia (15.1%) | 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Prevalence, Vision disorders, Eye diseases, Visual acuity, Primary health care
Pharmacodynamic Evaluation of PL2200 Versus Enteric-Coated and Immediate Release Aspirin in Diabetic Patients

Study Overview
=================
Brief Summary
-----------------
This study will determine if aspirin from PL2200, an investigational product, gets into the blood stream as quickly as plain aspirin and enteric coated aspirin, and to test whether PL2200 is able to prevent blood clots as effectively as these other products, when administered to patients with diabetes.

Official Title
-----------------
A Randomized, Actively Controlled, Crossover Pharmacodynamic Evaluation of PL2200 Versus Enteric-Coated and Immediate Release Aspirin in Patients With Type II Diabetes

Conditions
-----------------
Diabetes Mellitus, Type 2

Intervention / Treatment
-----------------
* Drug: PL2200 Aspirin Capsules
* Drug: Immediate-Release Aspirin Tablets
* Drug: Enteric-coated aspirin caplets


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adults 21-79 Body mass index (BMI) of 30-40 kg/m2 Non-insulin-dependent type-2 diabetics (as confirmed by hemoglobin A1c (HbA1c) of > 6.4% and/or fasting plasma glucose of >125 mg/dL or current anti-diabetic medication) AA-induced platelet aggregation response of >60% within 3 hours prior to initial dose of study drug administration Exclusion Criteria: Contraindications to aspirin Previous history of vascular disease Patient requires insulin Use of non-steroidal anti-inflammatory drugs, anti-secretory agents, antacids, and salicylate-containing nutritional supplements within 2 weeks of randomization

Ages Eligible for Study
-----------------
Minimum Age: 21 Years
Maximum Age: 79 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: PL2200 Aspirin Capsules<br>Investigational drug arm; crossover design | Drug: PL2200 Aspirin Capsules<br>* 325 mg aspirin; once per day for 3 days<br>|
| Active Comparator: Immediate-Release Aspirin Tablets<br>Active comparator; crossover design | Drug: Immediate-Release Aspirin Tablets<br>* 325 mg aspirin; once per day for 3 days<br>|
| Active Comparator: Enteric-coated aspirin caplets<br>Active comparator; crossover design | Drug: Enteric-coated aspirin caplets<br>* 325 mg aspirin; once per day for 3 days<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time to 99% Inhibition of Serum Thromboxane (TxB2) | Aspirin's antiplatelet activity is measured by the capacity of platelets to generate serum thromboxane (a surrogate marker for inhibition of COX-1 by aspirin). Inhibition of serum thromboxane is a key marker of antiplatelet efficacy. | 4 days |
Changes in the Distribution of Mitochondria During Oocyte Maturation

Study Overview
=================
Brief Summary
-----------------
Cytoplasmatic maturation is an important event in the general maturation of of the oocyte. Mitochondria is one of the major organelles involved in the process of cytoplasmatic maturation. The aim of this study is to investigate the presence and distribution of the mitochondria in the cytoplasma of immature oocytes that are retrieved in the routine in-vitro maturation cycle with intracytoplasmatic sperm injection (ICSI). These oocytes will not undergo ICSI because of their immaturity. Usually, they are discarded. In addition to these immature oocytes the investigators shall also investigate the mitochondria in mature oocytes that underwent ICSI but did not become fertilized and are discarded.

Conditions
-----------------
Infertility

Intervention / Treatment
-----------------
* Other: Fixation and staining
* Other: Observation by laser microscopy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Infertile patients needing IVF treatment Exclusion Criteria: Patients not requiring the ICSI procedure

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 44 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Immature oocytes (GV, M-I)<br> | Other: Fixation and staining<br>* Fixation and staining by MitiTracker Green FM<br>Other: Observation by laser microscopy<br>* Observation with Laser scanning confocal microscopy<br>|
| Mature oocytes (M-II)<br> | Other: Fixation and staining<br>* Fixation and staining by MitiTracker Green FM<br>Other: Observation by laser microscopy<br>* Observation with Laser scanning confocal microscopy<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The patterns of mitochondrial distribution within the cytoplasma of oocytes during nuclear maturation | Identification the different patterns of mitochondrial distribution in correlation with the 3 stages nuclear maturation in human oocytes | Three months |
The Crosstalk Between Calcium-sensing Receptor Signaling and Endocannabinoid System in Primary Hyperparathyroidism

Study Overview
=================
Brief Summary
-----------------
Despite the strong association of hyperparathyroidism with arachidonic acid related lipid signals, little research has been performed over the years. A better understanding of the link between arachidonic acid remodeling, prostaglandin and endocannabinoid production with primary hyperparathyroidism in primary tissue/cells might open up new avenues for biomarker and thus to a potential therapeutic target. Arachidonic acid remodeling might also have an impact on depression and elevated cytokines in patients with primary hyperparathyroidism. The investigators therefore will assess the correlation between postoperative improvement of PHQ-9 and cytokine levels with arachidonic acid remodeling.

Official Title
-----------------
The Crosstalk Between Calcium-sensing Receptor Signaling and Endocannabinoid System in Primary Hyperparathyroidism

Conditions
-----------------
Primary Hyperparathyroidism

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age ≥ 18 years Primary hyperparathyroidism with planned surgery Written informed consent Exclusion Criteria: Age <18 years Secondary/tertiary hyperparathyroidism Renal insufficiency Participant is pregnant Participant is incapable of giving an informed consent

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Activity-based protein profiling (ABPP) will be used to assess the enzymes involved in calcium induced stress signals and endocannabinoid activation |  | 2 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measurement of the level of parathyroid hormone |  | 2 months | 
| Measurement of the level of calcium |  | 2 months | 
| Measurement of the level of cortisol |  | 2 months | 
| Measurement of the level of 25-hydroxyvitamin D |  | 2 months | 
| Measurement of the levels of the enzymes involved in the endocannabinoid system activation (diacylglycerol lipase; monoacylglycerol lipase, phospholipases, cyclooxygenases) |  | 2 months | 
| Measurement of the level of endocannabinoids, arachidonic acid species, prostanoids and related anti-inflammatory lipids |  | 2 months | 
| Measurement of the level of IL-6 and TNF-α |  | 2 months | 
| Assessment of Patient Health Questionnaire - 9 | The Patient Health Questionnaire (PHQ-9) is described as a valid depression scale with good sensitivity and specificity for detecting depressive disorders, ranging from 1 to 27. Depression severity: 1 to 4: minimal; 5 to 9: mild; 10 to 14: moderate; 15 to 19: moderately severe; 20 to 27: severe | 2 months |
Amr's Maneuver and Postpartum Hemorrhage

Study Overview
=================
Brief Summary
-----------------
The impacts of using Amr's manoeuvre (cervical traction) on atonic postpartum hemorrhage is a randomized controlled, multi-centre study that aims to compare the incidence of post partum hemorrhage (PPH> 500 ml blood loss) within the first 24 hours of labor after using Amr's maneuver with active management of the third stage versus active management alone

Detailed Description
-----------------
Primary: Compare the incidence of post partum hemorrhage (PPH> 500 ml blood loss) within the first 24 hours of labor after using Amr's maneuver with active management of the third stage versus active management alone Secondary: Comparing: The amount of blood loss in each arm of the study Hematocrit before and after labor Duration from delivery of placenta till discharge from the delivery room

Official Title
-----------------
The Impacts of Using Amr's Maneuver (Cervical Traction) on Atonic Postpartum Hemorrhage; Multi-centre Randomized Controlled Study

Conditions
-----------------
Postpartum Hemorrhage

Intervention / Treatment
-----------------
* Procedure: Amr maneuver


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All pregnant females aged 18 years or more, candidate for normal vaginal delivery during the period of the study will be included Exclusion Criteria: Women presenting with pre-existing maternal hemorrhagic conditions such as factor 8 or 9 deficiency or Von Willebrand's disease or those who had assisted vaginal delivery

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Amr Maneuver<br>Active management of third stage plus Amr's maneuver | Procedure: Amr maneuver<br>* sustained traction of the anterior and posterior lips of the cervix by ovum forceps downwards and anteriorly until maximum yield for about 90 seconds<br>|
| No Intervention: Active management alone<br>Active management of third stage alone | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the incidence of postpartum hemorrhage | the incidence of post partum hemorrhage (PPH> 500 ml blood loss) within the first 24 hours of labor after using Amr's maneuver with active management of the third stage | 24 hour | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
postpartum hemorrhage, PPH, atonic, new maneuver
Use of Large Field of View During Image Acquisition for Coronary Angiography

Study Overview
=================
Brief Summary
-----------------
Coronary angiography exposes patients and physicians to ionizing radiation. The purpose of this study is to evaluate the routine use of large field of view during image acquisition for coronary angiography. Patients with indication of diagnostic coronary angiography will be randomized for the use of either large field of view during image acquisition or medium field of view. Patients, physician and nurse radiation exposure will be measured by digital dosimeter.

Official Title
-----------------
Preferential Use of Large Field of View During Image Acquisition for Coronary Angiography With Flat Detector Technology: a Simple Step to Reduce Radiation Exposure

Conditions
-----------------
Exposure to Ionizing Radiation, Occupational Exposure to Radiation, Radiation Injury

Intervention / Treatment
-----------------
* Radiation: Large field of view arm
* Radiation: Medium field of view


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Indication of diagnostic coronary angiography for suspected coronary artery disease Sign written consent form Exclusion Criteria: Therapeutics procedures Urgency/emergency procedures Previous CABG Severe valvular disease

Ages Eligible for Study
-----------------
Minimum Age: 21 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Large field of view<br>Patients will have coronary angiography performed with large field of view lens | Radiation: Large field of view arm<br>* Patients will be allocated in the large field of view arm. Coronary angiography will be performed with large field of view lens (25 cm)<br>|
| Active Comparator: Medium field of view<br>Patients will have coronary angiography performed with medium field of view lens | Radiation: Medium field of view<br>* Patients will be allocated in the medium field of view arm. Coronary angiography will be performed with medium field of view lens (20 cm)<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patient's radiation exposure | Patient's radiation exposure will be measured in mGy at the end of procedure | 24 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Physician and nurse radiation exposure | Physician and nurse radiation exposure will be measured in microSv at the end of procedure | 24 hours | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Exposure to Ionizing Radiation, Occupational Exposure to Radiation