Chronic Inflammation After Obesity Surgery

Study Overview
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Brief Summary
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To evaluate the impact of obesity surgery on chronic inflammation.

Detailed Description
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A retrospective study to compare the impact of laparoscopic sleeve gastrectomy (LSG), laparoscopic Roux-en Y- gastric bypass (LRYGB) and laparoscopic omega-loop gastric bypass (LOLGB) on chronic inflammation and metabolic syndrome.

Official Title
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Impact of Obesity and Metabolic Surgery on Chronic Inflammation

Conditions
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Obesity

Intervention / Treatment
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* Other: Laboratory Examination


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: BMI > 35kg/m² and obesity-related disease or BMI > 40kg/m² Exclusion Criteria: acute inflammation during laboratory examination

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| laparoscopic sleeve gastrectomy<br>patients who underwent laparoscopic sleeve gastrectomy (LSG) due to obesity and/or metabolic syndrome | Other: Laboratory Examination<br>* Laboratory Examination before, 1 month, 3 month, 6 month and up to 12 month after LSK, LRNYGB, LOLGB<br>|
| laparoscopic Roux-en-Y- gastric bypass<br>patients who underwent laparoscopic Roux-en-Y- gastric bypass (LRYGB) due to obesity and/or metabolic syndrome | Other: Laboratory Examination<br>* Laboratory Examination before, 1 month, 3 month, 6 month and up to 12 month after LSK, LRNYGB, LOLGB<br>|
| laparoscopic omega-loop gastric bypass<br>patients who underwent laparoscopic omega-loop gastric bypass (LOLGB) due to obesity and/or metabolic syndrome | Other: Laboratory Examination<br>* Laboratory Examination before, 1 month, 3 month, 6 month and up to 12 month after LSK, LRNYGB, LOLGB<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Chronic inflammation | the changing of leucocytes in /nl after obesity surgery | one day preoperatively, and 1 month, 3 month, 6 month and up to 12 month postoperatively | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fatty liver index | the changing of fatty liver index after obesity surgery | one day preoperatively and 1 month, 3 month, 6 month and up to 12 month postoperatively | 
| Liver enzymes | the changing of GOT in U/l, GPT in U/l, GGT in U/l, AP in U/l after obesity surgery | one day preoperatively and 1 month, 3 month, 6 month and up to 12 month postoperatively | 
| Body Mass Index (BMI) in kg/m² | the changing of BMI in kg/m² before and after obesity surgery | one day preoperatively and 1 month, 3 month, 6 month and up to 12 month postoperatively | 
| weight in kg | the changing of weight before and after obesity surgery | one day preoperatively and 1 month, 3 month, 6 month and up to 12 month postoperatively | 
| waist circumference | the changing of waist circumference in cm before and after obesity surgery | one day preoperatively and 1 month, 3 month, 6 month and up to 12 month postoperatively | 
| HbA1c | the changing of HbA1c in % and after obesity surgery | one day preoperatively and 1 month, 3 month, 6 month and up to 12 month postoperatively | 
| Chronic inflammation II | the changing of c-reactive protein in mg/l after obesity surgery | one day preoperatively and 1 month, 3 month, 6 month and up to 12 month postoperatively | 
| Acute inflammation | the changing of c-reactive protein in mg/l after obesity surgery | one day preoperatively and one and four days postoperatively | 
| Acute inflammation II | the changing of leucocytes in /nl after obesity surgery | one day preoperatively and one and four days postoperatively | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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chronic inflammation, fatty liver index