A Cohort of Patients With Chronic Pulmonary Disease

Study Overview
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Brief Summary
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This is a longitudinal study of following chronic pulmonary disease patients to observe and predict the clinical outcomes of these patients.

Detailed Description
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In patients with chronic pulmonary disease, impaired pulmonary function and limited exercise capacity, is a complex clinical syndrome with a wide range of underlying causes, which may result in worse quality of life and high economic burden. This is a longitudinal study of following chronic pulmonary disease patients, recording the clinical, pathophysiology, and psychological parameters, to observe and predict the clinical outcomes of these patients.

Official Title
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A Long-term, Prospective, Observational Cohort of Patients With Chronic Pulmonary Disease

Conditions
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Obstructive Pulmonary Disease

Intervention / Treatment
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* Other: observational cohort


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 18-80, males and females Patients are diagnosed as the obstructive pulmonary disease according to the clinical practice. Willing to participate in the study. Being able to provide informed consent. Exclusion Criteria: Subjects with severe heart failure, severe arrhythmias, unstable angina, and malignant comorbidities. Subjects with significantly impaired cognitive function and are unable to fulfill the study requirement (unable to provide informed consent) Subjects who participated in another trial within 30 days prior to the planned start of the study Subjects with cancer or have had cancer in the 5 years prior to study entry.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| CRD patients<br>Patients with chronic pulmonary disease like COPD, asthma, bronchiectasis, and etc. | Other: observational cohort<br>* Recording the clinical, pathophysiology, and psychological parameters, to observe and predict the clinical outcomes of these patients.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of acute exacerbations | The rate of exacerbations within 1 year of these patients will be tracked. | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Survival | The rate of survival within 1 year of these patients will be tracked. | 1 year | 
| Forced expiratory volume in 1 second | Forced expiratory volume in 1 second is a marker used to measure lung function and can help you monitor your lung diseases over time. | 1 year | 
| Health related quality of life: questionnaires | Using questionnaires to reflect the patients' health related quality of life. The questionnaires include: SF-36 (scores range between 0 and 100 and higher scores are attributed to better quality of life.) St. George's Respiratory Questionnaire (scores range between 0 and 100 and higher scores are attributed to worse quality of life.) Severe Respiratory Insufficiency Questionnaire (scores range between 0 and 100 and higher scores are attributed to better quality of life.) | 1 year | 
| 6-minute walk test | The 6-minute walk test plays a key role in evaluating functional exercise capacity, assessing prognosis and evaluating response to treatment across a wide range of respiratory diseases. | 1 year |