Inflammation and the Heart

Study Overview
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Brief Summary
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Studies have shown that people with rheumatoid arthritis (RA) have a higher rate of heart disease than people that do not have RA. we believe this is caused by the inflammation produced by RA.

Detailed Description
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Aim 1: We want to study people with RA to see if we can detect very early changes in their heart muscle and compare these results to people who do not have RA.

Official Title
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Inflammation and the Heart

Conditions
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Rheumatoid Arthritis

Intervention / Treatment
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* Other: cardiac Magnetic Resonance imaging


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Written informed consent Age >= 18 RA only: meet American College of Rheumatology(ACR)criteria for Diagnosis of RA Controls only: no evidence of RA or other inflammatory disease Exclusion Criteria: Previous or current heart failure or ischemic cardiovascular disease (eg stroke, myocardial infarction, angina, CABG, stent). Atrial fibrillation. Known structural or functional cardiac abnormality, including pulmonary htn. Glomerular filtration rate < 60 ml/min. Pregnancy or breastfeeding. Unable to perform MRI (claustrophobia, unable to fit in magnet,pacemaker,defibrillator or non-MR safe implant). Hypersensitivity to gadolinium.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: All participants underwent cardiac MRI(cMRI) using a 1.5 tesla Siemens Magnetom Avanto scanner to compare left ventricular structure and Left atrium size.
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: rheumatoid arthritis patients<br>People who have rheumatoid arthritis underwent cMRI | Other: cardiac Magnetic Resonance imaging<br> <br> |
| Other: controls<br>people who do not have RA or other inflammatory disease underwent cMRI | Other: cardiac Magnetic Resonance imaging<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Left Ventricular Mass Indexed to BSA, g/m^2 | Left Ventricular Mass (LVM) is known to increase in proportion to overall body size and differs by gender. To assess an individual's risk for a cardiovascular event based on LVM,an adjustment for the patient's body size should be done. LVM in grams was divided by body surface area in meters squared, to adjust for body size. Body surface area was calculated by square root (height (cm) X weight (kg)/3600). | one scan, cross sectional comparison | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Left Atrium Size, mm | left atrium size, measured in millimeters | one scan, cross sectional comparison | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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rheumatoid arthritis, inflammation