Abdominal Muscle Thickness in Mechanically Ventilated Patients

Study Overview
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Brief Summary
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The purpose of the study is to determine to what extent the abdominal muscles contribute to airway pressure, in order to investigate the correlation between muscles weakness and extubation outcome in mechanically ventilated patients. In addition the reliability of the sonographic measurements will be assessed.

Detailed Description
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The purpose of the study is to determine to what extent the abdominal muscles contribute to airway pressure, in order to investigate the correlation between muscles weakness and extubation outcome in mechanically ventilated patients. In addition the reliability of the sonographic measurements will be assessed.

Official Title
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Abdominal Muscle Thickness in Mechanically Ventilated Patients During Spontaneous Breathing Trials

Conditions
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Muscle Weakness, Weaning Failure

Intervention / Treatment
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* Diagnostic Test: Abdominal muscles ultrasound


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: greater than 18 years old Patients requiring invasive mechanical ventilation including patients with endotracheal tube and tracheotomies Exclusion Criteria: Patients with a previously diagnosed neuromuscular disorder (acute or chronic) Behavioural agitation Patients who are not awake and cooperative Previously enrolled in the study

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Mechanically ventilated patients<br>Abdominal muscles ultrasound | Diagnostic Test: Abdominal muscles ultrasound<br>* Abdominal muscles ultrasound during a spontaneous breathing trial using the M-mode to calculate the thickening fraction of the anterior and lateral abdominal muscles under multiple circumstances (tasks performed by the patients)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between thickening fraction and SBT outcome | Correlation between thickening fraction of each muscles evaluated by ultrasound before the SBT and the SBT outcome. | Measurements will be performed before SBT | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between the pressures generated by respiratory muscles and SBT outcome | Correlation between the pressures generated by respiratory muscles during the ultrasound measurements (Twice Transdiaphragmatic pressure, TwPdi; maximal inspiratory pressure, MIP) and SBT outcome | Measurements will be performed before SBT | 
| Inter-rater agreement | Concordance of measurements of abdominal muscle thickness and thickening fraction in mechanically ventilated patients performed by two different observers will be evaluated. | Measurements will be performed before SBT | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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abdominal muscles, spontaneous breathing trial, critically ill patients