Rosmarinus Officinalis Versus 2.5%Sodium Hypochlorite as Root Canal Irrigants

Study Overview
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Brief Summary
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To measure the Effect of Rosmarinus Officinalis versus 2.5%Sodium Hypochlorite as Root canal Irrigants on the Intensity of post-operative pain and Bacterial Reduction in asymptomatic necrotic Mandibular premolars.

Official Title
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Effect of Rosmarinus Officinalis Versus 2.5%Sodium Hypochlorite as Root Canal Irrigants on the Intensity of Post-operative Pain and Bacterial Reduction in Asymptomatic Necrotic Mandibular Premolars

Conditions
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Necrotic Pulp

Intervention / Treatment
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* Other: Rosmarinus Officinallis


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Systematically healthy patient (ASA I and II). Age between 20 and 45 years with no sex predilection Mandibular permanent premolar teeth: Diagnosed clinically with pulp necrosis. Absence of spontaneous pain. Radiographic evidence of root and root canal. Slight widening in the periodontal membrane space or with periapical radiolucency. No response to cold pulp tester (ethyl chloride spray) Patients who can understand and interpret Numerical rating scale (NRS). Patients' acceptance to participate in the trial Exclusion Criteria: 1- Medically compromised patients having significant systemic disorders. (ASA III or IV). 2- History of intolerance to NSAIDS. 3- If analgesics or antibiotics have been administrated by the patient during the past 24 hours preoperatively as it might alter their pain perception. 4- Pregnant women: Avoid radiation exposure, anesthesia, and medication. 5- Teeth with: i. Vital teeth. ii. Double canal mandibular premolar teeth iii. Association with swelling or fistulous tract. iv. Acute peri-apical abscess and swelling: Need special treatment steps which could involve additional visits with incision and drainage. Also, it could influence initiation and progression of postoperative pain. v. Mobility Grade II or III. vi. Pocket depth more than 5mm. vii. Previous root canal therapy. viii. Non-restorable teeth: Hopeless tooth Immature teeth. Radiographic evidence of external or internal root resorption vertical root fracture, perforation, calcification.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Experimental<br>Rosmarinus officinals will be used as root canal irrigant in treating aysymptomatic mandibular premolars. | Other: Rosmarinus Officinallis<br>* Root canal Irrigants<br>|
| No Intervention: Control Group<br>Sodium Hypochlorite used as control in root canal irrigations in treating a asymptomatic mandibular premoalrs. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative pain after root canal treatment. | The patient is asked to grade his degree of pain on the Numerical Rating Scale (NRS) chart which is an 11 points scale consisting of numbers from 0 to 10, where zero reading represents no pain , 1-3 readings represent mild pain, 4-6 readings represent moderate pain. 7-10 readings represent severe pain . | Up to 48 hours postoperative. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Intracanal bacterial load change. | The intracanal bacterial load change is calculated through using colony forming units per milliliter test before and after root canal preparation. | First as a base line and after 15 minutes ( End of the chemo-mechanical preparation). |