A Study of Topical Arnica & Ledum on Bruise Reduction in HNV

Study Overview
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Brief Summary
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Subjects will have a bruise induced. A pad containing either a placebo or active will be applied to the bruise. Photographs will be taken over the following days to record bruise healing.

Detailed Description
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This is a randomized, double-blind, placebo-controlled, crossover, multicenter study that will be used to evaluate the difference in bruise reduction efficacy between active remedy and placebo when a mechanical bruise is induced. The trial will be conducted at 5-8 sites with up to 150 subjects. Each subject will be injured two times using the same bruise-inducing mechanism, and the resulting bruises will be treated with active remedy or placebo-infused pads that will be identical in appearance. Subjects and study investigators will be blinded to the order of treatment assignment. Subjects will be asked to come to the clinic for photographic assessments of the bruise. Each subject will be randomly assigned to have a placebo or active remedy pad applied over each mechanically induced bruise on Day 1. The pad will be applied by study staff immediately after bruise induction (within 5 minutes). The pad will cover the bruised area completely, and then sealed with Tegaderm. All procedures, including bruise induction, treatment, and photography, will be administered by study staff who are blinded to treatment type. All photographs will be rated according to standardized criteria by blinded, trained study investigators after the completion of all subject data collection.

Official Title
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A Randomized, Double-Blind, Placebo-Controlled, Crossover Study of Arnica Montana and Ledum Palustre Formulation on Mechanically Induced Bruising in Healthy Normal Volunteers

Conditions
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Bruise, Contusion

Intervention / Treatment
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* Other: Arnica montana, Ledum palustre


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Fitzpatrick skin type 1-3 BMI 25 kg/m2 Self described bruisers Intact skin in the target area, free of markings, blemishes and hair Exclusion Criteria: Use of recreational drugs, steroids, pain medications, other homeopathic remedies, anticoagulant therapies, antiplatelet therapy Known history of dermal sensitivity, serious illness, hematological abnormality, impaired wound healing Inability to forego application of topical products in the target area Hair removal by laser, wax or chemicals within one week prior to Day 1 Avoid tanning beds History of allergy to topical gels, Arnica or Ledum Active wound or infection in the target area History of keloids or hypertrophic scarring History of collagen or vascular disease History of organ transplant

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Active<br>Arnica montana and Ledum palustre infused Pad | Other: Arnica montana, Ledum palustre<br>* Homeopathic<br>|
| Placebo Comparator: Placebo<br>Pad (Matching appearance with Active) | Other: Arnica montana, Ledum palustre<br>* Homeopathic<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Efficacy | Time to bruise healing in active vs. placebo | 11 days |