linjc16/ctgov huggingface dataset:
A Qualitative Study on CSII in Children and Adolescents Having Type 1 Diabetes

Study Overview
=================
Brief Summary
-----------------
Using qualitative method; a qualitative case study using semi-structured interviews to explore patients' experiences. Study population of insulin pump patients aged 11-18 years old will be recruited from pediatrics with T1D at Dasman Diabetes Institute; who started using CSII at least one year ago and their parents. Semi-structured interviews will be recorded and then transcribed word by word. Data analysis will be performed using an inductive thematic approach.

Detailed Description
-----------------
SPECIFIC AIMS To explore the experiences of adolescents and their parents and parents ofi children with type 1 diabetes in Kuwait about the use of Insulin Pump Therapy (IPT) in the context of their quality of life. To gain in-depth understanding of the perceptions of adolescents and their parents and parents of children with type 1 diabetes in Kuwait with T1DM about IPT and its use for diabetes management. Design A qualitative case study methodology will be adopted using semi-structured interviews for data gathering. Interviews will be conducted with a purposive sample including adolescents and their parents and parents of children with type 1 diabetes in Kuwait with T1D, who are on CSII therapy at least 12 months, along with their parents.

Official Title
-----------------
A Qualitative Study on the Experiences and Expectations of Children and Adolescents Having Type 1 Diabetes Towards Insulin Pump Therapy and Its Effect on Their Quality of Life in Kuwait

Conditions
-----------------
Type 1 Diabetes Mellitus

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosis of T1 D in Kuwait as specified by their Consultant and in line with the Kuwait Clinical Guidelines diagnosis of T1D (2006) criteria Adolescents between the age of 11 and 18 or children between 2 and 10 years old Kuwaiti or expats Duration of CSII (Insulin Pump Therapy) at least 12 months. Prior to starting Insulin Pump Therapy must have been on MDI for a minimum of 12 months Attend the Insulin Pump clinic at DDI Exclusion Criteria: Non-English & non-Arabic speakers Presence of a learning disability Diagnosis of any diabetes complication before starting the CSII therapy Diagnosis of psychological problem

Ages Eligible for Study
-----------------
Minimum Age: 4 Years
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Impact of IPT on QoL of children and adolescents from their perspective and their parents' perspective |  | 2 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Children, Adolescents, Parents, Insulin Pump Therapy
Alveolar Bone Loss Around 3 Different Designs of Dental Implant: Prospective Comparative Clinical Trail

Study Overview
=================
Brief Summary
-----------------
comparison of alveolar bone resorbtion/ changes for a period of 12 month post loading of different designs and brands of oral implants. in this study, a comparison between straumann SLA-active implants to MIS Mistral and Mistral -X implants.

Official Title
-----------------
Alveolar Bone Loss Around 3 Different Designs of Dental Implant: Prospective Comparative Clinical Trail

Conditions
-----------------
Alveolar Bone Loss

Intervention / Treatment
-----------------
* Device: oral implant


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: healthy >18Y consent posterior mandibular missing teeth Exclusion Criteria: chronic illness: diabetes, artheritis women: pregnancy, lactation non consent alcohol consumption smoking >10 p day

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single


Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: oral implant|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| radiographic changes in the alveolar bone height around the oral implant till 12 m post loading |  | 12 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
alveolar bone, radiographic alveolar bone changes around oral implants of various designs 12 m post loading
Sleep Spindles and Memory in Rolandic Epilepsy

Study Overview
=================
Brief Summary
-----------------
The investigators are recruiting children with Rolandic epilepsy and children without epilepsy (aged 4 years old and above) for a non-invasive brain imaging study using Magnetic Resonance Imaging (MRI), Magnetoencephalography/Electroencephalography (MEG/EEG), and experimental tasks. The investigators hope to determine the brain circuits and brain rhythms affected in these children and ultimately identify new treatment options for childhood epilepsy patients.

Detailed Description
-----------------
This is a prospective study of epilepsy biomarkers in a total of 100 subjects of ages 4-18. Participants will spend about 5 hours at the Massachusetts General Hospital (MGH) Athinoula A. Martinos Center for Biomedical Imaging. They will undergo training on a memory task concurrent with EEG/MEG recordings. During the EEG, subjects will wear headphones that will deliver a quiet pink noise stimulus intermittently during a nap. The auditory stimulus will be calibrated in volume to not cause arousals. After napping, subjects will undergo cognitive testing and memory task testing.

Official Title
-----------------
Auditory Stimulation Effect on Spindles and Sleep Dependent Learning in Rolandic Epilepsy

Conditions
-----------------
Rolandic Epilepsy, Rolandic Epilepsy, Benign, Centrotemporal Epilepsy, Centrotemporal; EEG Spikes, Epilepsy of Childhood, Epilepsy; Seizure, Epilepsy

Intervention / Treatment
-----------------
* Other: Auditory stimulation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Ages 4-18 years Diagnosed with childhood epilepsy with centrotemporal spikes (CECTS) or Rolandic epilepsy by child neurologist Has EEG with sleep activated centrotemporal spikes Has had at least 1 focal motor or generalized seizure Exclusion Criteria: Has abnormal brain MRI Has other unrelated neurological disease Unable to have an MRI/MEG Claustrophobic History of frequent vomiting Permanent metal in body, braces Over MRI weight limit: 350lbs

Ages Eligible for Study
-----------------
Minimum Age: 4 Years
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Children and adolescents with epilepsy and controls<br>Closed loop auditory stimulation during nap | Other: Auditory stimulation<br>* Quiet auditory stimulation timed with sleep physiology<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Spindle Density | Spindle count per minute during non-rapid eye movement (NREM) sleep | 1-5 hours | 
| Memory performance | Percent improvement in memory task performance | 1-5 hours |
Institutional Registry of Haemorrhagic Hereditary Telangiectasia

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to create an institutional and population-based registry of Haemorrhagic Hereditary Telangiectasia with a prospective survey based on epidemiological data, risk factors, diagnosis, prognosis, treatment, monitoring and survival. This study will also describe the occurrence of Haemorrhagic Hereditary Telangiectasia in the population of HIBA in the Central Hospital, as well as the characteristics of clinical presentation and evolution.

Detailed Description
-----------------
Haemorrhagic Hereditary Telangiectasia is a uncommon autosomic hereditary disorder caracterizad for recurrent epistaxis,cutaneomucous telangiectasias and arteriovenous malformations in diferent organs; brain, lung, liver and gastrointestinal are more often afected . Afect one in 5000-8000 individual in worldwide. HHT may produce important morbidity like brain absces, stroke, hemoptisis and cronic ferropenic anemia. Molecular mechanism of this disorder are complex and still no fully dilucidated. The genes mutated in HHT encode endothelial cell-expressed proteins that mediate signalling by the transforming growth factor (TGF)b superfamily. Endoglin (HHT type I) and ACVRL-1 (HHT type 2) mutations are responsible in more than 80% of the individuals. Mutation of SMAD 4 protein (MADH4)cause HHT in association with juvenile polyposis. HHT may associated with primary pulmonary hypertension en more rare cases. There arent HHT register in Argentina and Latinamerican population. This registry may gader valious information in order to generate a better diagnosis and treatment of our population and others.

Official Title
-----------------
Institutional Registry of Haemorrhagic Hereditary Telangiectasia

Conditions
-----------------
Haemorrhagic Hereditary Telangiectasia

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with HHT defined. Followed in Unidad HHT of Hospital Italiano de Buenos Aires. Exclusion Criteria: 1. Denied to participated in the registry or inform consent process.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| morbidity | Control visit every three month | 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Haemorrhagic Hereditary Telangiectasia, Rendu Osler Weber Syndrome, Osler Weber Rendu Syndrome, HHT
Radiofrequency (RF) Ablation Prospective Outcomes Study

Study Overview
=================
Brief Summary
-----------------
The objective of this study is to compile real-world outcomes of Boston Scientific commercially approved radiofrequency (RF) ablation systems in the treatment of patients diagnosed with pain and in use for central nervous system (CNS) applications for other disorders.

Official Title
-----------------
Radiofrequency (RF) Ablation Prospective Outcomes Study

Conditions
-----------------
Pain, Chronic

Intervention / Treatment
-----------------
* Device: Radiofrequency Ablation


Participation Criteria
=================
Eligibility Criteria
-----------------
Key Inclusion Criteria: Study candidate is scheduled to be treated with a commercially approved Boston Scientific RF system for pain or for CNS applications per local Directions for Use (DFU) Signed a valid, IRB/EC/REB-approved informed consent form Key Exclusion Criteria: Meets any contraindications per locally applicable Directions for Use (DFU) Currently diagnosed with cognitive impairment, or exhibits any characteristic, that would limit study candidate's ability to assess pain relief or to complete study assessments

Ages Eligible for Study
-----------------
Minimum Age: 0 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Boston Scientific Radiofrequency Ablation Systems<br>Subjects with pain or other disorders treated with a commercially approved Boston Scientific RF system | Device: Radiofrequency Ablation<br>* Radiofrequency Ablation for treatment of chronic pain or other disorders<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Responder rate | Proportion of subjects with a 30 percent or greater reduction from Baseline in targeted pain intensity | 1 month post-procedure | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Radiofrequency (RF)
The Bipolar Illness Onset Study (the BIO Study)

Study Overview
=================
Brief Summary
-----------------
This longitudinal study aims to identify 1) a composite blood-based biomarker, 2) a composite electronic Smartphone-based biomarker and 3) a neurocognitive signature for bipolar disorder

Detailed Description
-----------------
The study will include 300 patients with newly diagnosed/first episode bipolar disorder, 200 healthy siblings or child family members and 100 healthy individuals without a family history of affective disorder. All individuals will be investigated with repeated blood tests, Smartphone recordings, neuropsychological tests and brain imaging during a five to ten year study period.

Official Title
-----------------
The Bipolar Illness Onset Study (the BIO Study)

Conditions
-----------------
Bipolar Disorder

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Newly diagnosed/first episode bipolar patients, First-generation relatives (siblings and children aged 15 to 40 years) to the recruited newly diagnosed/first episode bipolar patients. Age- and gender matched sample of healthy individuals without a first-generation family history of effective disorders Exclusion Criteria: Significant physical disorders Schizophrenia or related disorders

Ages Eligible for Study
-----------------
Minimum Age: 16 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with bipolar disorder<br>Patients with newly diagnosed bipolar disorder | |
| Healthy first generation relatives<br>Healthy first generation relatives to the included patients | |
| Healthy individuals<br>Healthy individuals without a family history of psychiatric disorders | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Composite blood based biomarker |  | 5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Composite smartphone based biomarker including self reported and smartphone generated data | Composite smartphone based biomarker including 1) self reported data and 2) smartphone generated data on physical activity 3) social activity and 4) voice features collected during phone calls | 5 years | 
| Composite neurocognitive marker including Cold and Hot cognition. | Composite neurocognitive marker including Cold cognition assessed with neuropsychological tests probing verbal memory and executive function and Hot cognition assessed with a comprehensive computerized battery of cognitive tests probing (i) emotional processing (ii) reward processing and (iii) emotional regulation. | 5 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Bipolar disorder, Blood, Smartphone, Brain imaging, Cognition, Neuropsychology
Repeatability of X-Ray, MRI, and Gait Analysis

Study Overview
=================
Brief Summary
-----------------
The purpose of this preliminary substudy to the parent study Aerobic Exercise Intervention for Knee Osteoarthritis is to determine the repeatability and reproducibility of various measurement techniques.

Detailed Description
-----------------
The purpose of this preliminary substudy to the parent study Aerobic Exercise Intervention for Knee Osteoarthritis is to determine the repeatability and reproducibility of various measurement techniques. The study will enroll healthy volunteers. All participants will receive x-rays and MRI examinations of the knees. Walking characteristics will be evaluated in a Motion Analysis Lab; this will involve taping reflective markers to participants' skin and having them walk on a level surface and up and down stairs. All participants will be evaluated two times, with a 1-week period between evaluations.

Official Title
-----------------
Repeatability of X-Ray, MRI, and Gait Analysis

Conditions
-----------------
Healthy

Intervention / Treatment
-----------------
* Other: Gait analysis, knee x-ray, and knee MRI


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy adults Exclusion Criteria: Previous knee injury, knee pain, or knee osteoarthritis

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>Healthy adult participants with no history of knee injury or osteoarthritis. | Other: Gait analysis, knee x-ray, and knee MRI<br>* Gait analysis, knee x-rays, and knee MRIs will be done twice for each participant, 1 week apart.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Day-to-day and inter/intra examiner repeatability of the techniques to be used in NIH grant R01 AR48768 |  | Measured two times, with a 1-week period between evaluations | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Healthy adult normals
Molecular Imaging of Brain Inflammation in Depressive Disorders

Study Overview
=================
Brief Summary
-----------------
In a number of neuropsychiatric disorders such as depression, both brain inflammation and glutamate mediated excitotoxicity (cell death through over-activated stimulation) are suspected to play a key role. It is difficult, if not impossible, to determine the potential destructiveness of the inflammatory response seen in disease states by studying the brain's inflammatory cells (microglia) activity in isolation. The investigators are proposing to develop the means to concurrently study inflammatory response (i.e., microglial activity) and its potentially devastating consequence (i.e., glutamate excitotoxicity) across the entire brain in order to establish the importance of inflammation. In this study the investigators propose a phased clinical study whereby the early-phase involves the development of our capacity to study inflammation-mediated damage to brain cells, followed by a feasibility study in patients with clinical depression that tests whether concurrent inflammation and glutamate excess could be measured in key brain regions associated with a depressed mood state.

Official Title
-----------------
Molecular Imaging of Brain Inflammation in Depressive Disorders

Conditions
-----------------
Depressive Disorder, Major, Positron-Emission Tomography

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: screening form for MRI/PET is satisfactory after being reviewed by a radiologist diagnosed with depression or healthy control participants with no present mental health disorder Good general health with no diseases expected to interfere with the study Subject is not pregnant, lactating, or of childbearing potential (must be practicing effective form of birth control) Patient and healthy controls must not have an infection or an autoimmune disorder or persistent inflammation. Exclusion Criteria: Any significant systemic illness or unstable medical condition which could lead to difficulty complying with the protocol use of Investigational agents within last month

Ages Eligible for Study
-----------------
Minimum Age: 19 Years
Maximum Age: 105 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| PET/MRI using 18[F]EPPA ligand<br>given experimental ligand FEPPA during MRI/PET scan to identify glutamate activity in the brain using FEPPA ligand | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| inflammation-related excitotoxicity in the brain | Cross sectional MRI/PET scan will be used to identify inflammation related excitotoxicity in the brain in healthy individuals and those diagnosed with major depression. | single time. Data collected at baseline with no follow up. |
Hemodynamic Changes of Patients Receiving Atenolol/Bisoprolol

Study Overview
=================
Brief Summary
-----------------
At hemodynamic level, the greater affinity of bisoprolol by the beta 1 receptor in theory could improve the peripheral arterial perfusion and could have a greater antihypertensive effect. At the same time, this could carry objectifiable improvements in the vascular tree, such as the level of arterial stiffness. This study attempts to mark the hemodynamic differences in the same individual with hypertension and metabolic syndrome who will be exposed to both drugs at different moments. Parameters will be objectified with impedance cardiography, pulse wave velocity and central blood pressure assessment before and after taking each one of the drugs. The results will be compared to the baseline data and between themselves.

Official Title
-----------------
Comparison of the Hemodynamic Changes in Patients Under Treatment With Bisoprolol Versus Atenolol

Conditions
-----------------
Hypertension, Metabolic Syndrome

Intervention / Treatment
-----------------
* Drug: Atenolol
* Drug: Bisoprolol


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Hypertension Metabolic syndrome Exclusion Criteria: Severe hypertension >180/110 Secondary hypertension Contraindication for betablockers Prior treatment with betablockers (up to one month before inclusion) History of neoplastic disease Patients that do not sign informed consent

Ages Eligible for Study
-----------------
Minimum Age: 21 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Atenolol-Bisoprolol<br> | Drug: Atenolol<br>* Crossover (atenolol 25-50 mg, bisoprolol 2.5-5 mg)<br>Drug: Bisoprolol<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| central blood pressure |  | two months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| peripheral resistance |  | two months | 
| cardiac index |  | two months | 
| pulse wave velocity |  | two months |