Immersive Virtual Reality for Neuropathic Pain

Study Overview
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Brief Summary
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Investigating how neuropathic limb pain, including phantom limb pain or complex regional pain syndrome, is affected by virtual reality. While several studies have looked into virtual reality for treating this type of pain, few have used the latest immersive virtual reality hardware combined with motion control for an engaging virtual mirror therapy experience. The investigators are interested in studying the use of virtual reality as an alternative treatment option for these conditions.

Official Title
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Management of Pain in Limb Neuropathic Conditions Through Immersive Virtual Reality

Conditions
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Neuropathy, Phantom Limb Pain, Complex Regional Pain Syndromes, Neuropathic Pain

Intervention / Treatment
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* Other: Immersive Virtual Reality


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosis of complex regional pain syndrome or phantom limb pain in an upper or lower limb Exclusion Criteria: Cognitive impairment leading to inability to make own medical decisions Complete inability to utilize leg or arm muscles that are needed for motion controller tracking History of seizures within the last year

Ages Eligible for Study
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Minimum Age: 12 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Limb neuropathic conditions<br>Includes phantom limb pain, complex regional pain syndrome | Other: Immersive Virtual Reality<br>* Participants will engage in virtual visualization therapy in an immersive virtual reality environment<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Feasibility of Virtual Reality Environment Use Questionnaire | Using a questionnaire, feedback over participant self-reported tolerance of the virtual reality environment, participant likelihood of recommending this therapy to others with similar conditions, reported sense of presence in presented scenario(s), comfort of virtual reality devices, impact on self-reported functional ability outside of clinic, and overall impression of virtual reality therapy will be recorded. | Immediately following final virtual reality session | 
| Pain Relief with Virtual Reality Therapy: Wong-Baker Scale | Change in Wong-Baker Faces pain scale will be measured. This will be done by obtaining pain scale scores immediately prior to therapy session, immediately following therapy, and several weeks post last therapy session. | Change from initial scores prior to virtual reality exposure to immediately prior to and following virtual reality sessions, and up to 8 weeks following last sessions | 
| Pain Relief with Virtual Reality Therapy: Visual Analog Scale | Change in Visual Analog Pain Scale will be measured. This will be done by obtaining pain scale scores immediately prior to therapy session, immediately following therapy, and several weeks post last therapy session. | Change from initial scores prior to virtual reality exposure to immediately prior to and following virtual reality sessions, and up to 8 weeks following last sessions | 
| Pain Relief with Virtual Reality Therapy: Short-Form McGill Pain Scale | Change in Short-Form McGill Pain Questionnaire will be measured. This will be done by obtaining pain scale scores immediately prior to therapy session, immediately following therapy, and several weeks post last therapy session. | Change from initial scores prior to virtual reality exposure to immediately prior to and following virtual reality sessions, and up to 8 weeks following last sessions |