Evaluation of the Presence of Enthesitis in Patients With Acne Vulgaris

Study Overview
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Brief Summary
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Acne vulgaris is an inflammatory disease of the pilosebaceous unit, affecting about 85% of the young population. In the studies p. acne is a potent stimulator of the release of IFN-gamma (IFN-)) and IL-17 from CD4 + T cells, and the presence of IL-17 + cells in the perifollicular infiltrate has been shown in biopsies of inflammatory acne lesions. Therefore, acne is thought to be a Th17-related disease (1). This study was aimed to evaluate the presence of enthesitis in patients with acne vulgaris.

Detailed Description
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Patients with acne vulgaris and healthy controls aged between 18-25 who admitted to Hitit University Erol Olcok Education and Research Hostpital Dermatology policlinic will be icluded. Patients with rheumatic, neurological diseases, history of trauma and previous fractures will be excluded from the study. After all the participants were evaluated by the dermatologist and demographic data will be recorded, the participants will be examined by the physical medicine and rehabilitation specialist and the short form-36 (sf-36), hospital anxiety and depression scale will be completed. Bilateral lower extremity tendon thicknesses and the presence of erosion, bursitis, etc. will be evaluated according to the criteria of Guess (Glasgow Ultrasound Enthesitis Scoring System) and Guess score will be determined for all participants. A total of 48 participants, 24 patients with acne vulgaris and 24 healthy controls, will be included in the study (2).

Official Title
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Evaluation of the Presence of Enthesitis in Patients With Acne Vulgaris

Conditions
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Enthesitis, Acne Vulgaris, Ultrasonography

Intervention / Treatment
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* Diagnostic Test: ultrasonography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteira: Patients with acne vulgaris and healthy controls aged between 18-25 Exclusion Criteria: Participants with rheumatic and neurologic disease, history of trauma ,

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 25 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with acne vulgaris<br>patients with acne vulgaris aged between 18-25 year | Diagnostic Test: ultrasonography<br>* all participants will be determined by ultrasonography.<br>|
| Healthy controls<br>healthy controls aged between 18-25 year | Diagnostic Test: ultrasonography<br>* all participants will be determined by ultrasonography.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| patellar tendon thicknesses of patients with acne vulgaris and healthy controls |  | 3 months | 
| Ashilles tendon thicknesses of patients with acne vulgaris and healthy controls |  | 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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enthesitis, acne vulgaris, Guess