Prognostic and Clinical Impact of Cardiovascular Involvement in Patients With COVID-19

Study Overview
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Brief Summary
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COVID-19 infection has been associated with numerous cardiac manifestations. Indeed, SARS-CoV-2 may impact on cardiovascular system through a direct myocardial infection or a secondary cardiac involvement due to hypoxia or metabolic supply-demand imbalance or prothrombotic inflammatory state. As a consequence of and besides acute myocardial damages, COVID-19 could also determine chronic cardiovascular consequences, with a significant impact on long-term prognosis, quality of life and functional capacity of COVID-19 survivors. On this basis, we aim to define the clinical and prognostic effects of myocardial involvement in COVID-19 patients.

Detailed Description
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COVID-19 infection has been associated with numerous cardiac manifestations. Indeed, SARS-CoV-2 may impact on cardiovascular system through a direct myocardial infection or a secondary cardiac involvement due to hypoxia or metabolic supply-demand imbalance or prothrombotic inflammatory state. As a consequence of and besides acute myocardial damages, COVID-19 could also determine chronic cardiovascular consequences, with a significant impact on long-term prognosis, quality of life and functional capacity of COVID-19 survivors. On this basis, we aim to define the clinical and prognostic effects of myocardial involvement in COVID-19 patients, with a 1-month and 6-month follow-up composed of clinical evaluation, electrocardiogram, trans-thoracic echocardiogram, cardiovascular magnetic resonance, chest computerized tomography scan and cardiopulmonary exercise test.

Official Title
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Prognostic and Clinical Impact of Cardiovascular Involvement in Patients With COVID-19 (Rilevanza Clinica e Prognostica Del Coinvolgimento Cardiovascolare Nei Pazienti Affetti da COVID-19)

Conditions
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Covid19, Myocardial Injury, Cardiovascular Diseases, Heart Failure, Cardiovascular Morbidity

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients who were hospitalized for COVID-19 Exclusion Criteria: None.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cardiovascular mortality | Mortality due to cardiovascular causes at 1 month after hospitalization | 1 month | 
| Cardiovascular mortality | Mortality due to cardiovascular causes at 6 months after hospitalization | 6 months | 
| All-cause mortality | Mortality due to all causes at 1 month after hospitalization | 1 month | 
| All-cause mortality | Mortality due to all causes at 6 months after hospitalization | 6 months | 
| Major adverse cardiovascular events (myocardial infarction, cerebrovascular accident, hospitalizations due to heart failure, revascularizations, cardiovascular mortality) | Major adverse cardiovascular events at 1 month after hospitalization | 1 month | 
| Major adverse cardiovascular events (myocardial infarction, cerebrovascular accident, hospitalizations due to heart failure, revascularizations, cardiovascular mortality) | Major adverse cardiovascular events at 6 months after hospitalization | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| NYHA class | NYHA functional class: from I (no limitation of physical activity) to IV (severe limitation with symptoms at rest) | 6 months | 
| Left ventricular systolic function (cardiac magnetic resonance, echocardiography) | Left ventricular systolic function evaluated with multimodality imaging | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cardiovascular involvement, COVID-19