Ketamine Associated With Morphine PCA After Total Hip Arthroplasty

Study Overview
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Brief Summary
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Ketamine (an analgesic drug often associated with morphine in the treatment of Opioid Induced Hyperalgesia) is often mixed in Morphine PCA syringe. We make the hypothesis that ketamine administrated separately via a continuous infusion, could induced a better analgesic effect. We will perform a randomised double blind study to determine the best infusion mode of intravenous ketamine, associated with morphine in PCA syringe or alone in continuous infusion.

Detailed Description
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Double blind study to determine the best infusion mode of intravenous ketamine, associated with morphine in PCA syringe or alone in continuous infusion

Official Title
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Impact of the Route of Administration of Ketamine Associated With Morphine PCA on Analgesia After Total Hip Arthroplasty

Conditions
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Arthroplasty, Replacement, Hip

Intervention / Treatment
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* Drug: Ketamine-Morphine
* Drug: Morphine
* Drug: Postoperative PCA of Ketamine and morphine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: total hip arthroplasty Exclusion Criteria: pre operative opioid administration

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: A<br>Ketamine pre and per operative, and morphine postoperative | Drug: Ketamine-Morphine<br>* Ketamine bolus preoperative and syringe pump peroperative, and morphine postoperative (PCA)<br>* Other names: Ketamine pre and per operative, and morphine postoperative;|
| Active Comparator: B<br>NaCl pre and per operative, and morphine postoperative | Drug: Morphine<br>* Bolus preoperative of NaCl and syringe pump peroperative of NaCl, and morphine postoperative (PCA)<br>|
| Experimental: C<br>Ketamine and morphine postoperative | Drug: Postoperative PCA of Ketamine and morphine<br>* Bolus preoperative of NaCl and syringe pump peroperative of Ketamine, and morphine postoperative (PCA)<br>* Other names: Ketamine Morphine;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Morphine consumption in PACU and in hospitalisation room |  | at 24 and 48 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative Visual Analogic Score of pain |  | in Recovery Room, at 24 and 48 hours, in the ward | 
| Postoperative Measure of mechanical hyperalgesia by Von Frey filament device |  | 24 and 48 hours in the ward | 
| Postoperative measure Ketamine and Nor-Ketamine blood levels |  | at 24 and 48 hours in the ward | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Ketamine, Morphine, PCA, Hyperalgesia, Nor-ketamine