Continuous Glucose Monitoring of Late Preterm Birth After Corticosteroids

Study Overview
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Brief Summary
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Women undergoing late preterm birth are at high risk of delivering a newborn with neonatal hypoglycemia. The investigators plan to monitor interstitial glucose levels prior to delivery in these women in order to develop a better understanding of the relationship between maternal hyperglycemia and neonatal hypoglycemia.

Official Title
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An Observational Study to Predict Neonatal Hypoglycemia Using Antenatal Continuous Glucose Monitoring Among Late Preterm Parturients Receiving Corticosteroids

Conditions
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Pregnancy Preterm, Neonatal Hypoglycemia, Prematurity

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Pregnancy admitted to labor and delivery between 34w0d and 36w5d English speaking women High probability of delivery in late preterm period defined by any of the following: Membrane rupture by 2 criteria (pooling, positive nitrazine, or ferning) OR leaking amniotic fluid from the cervix Preterm labor with intact membrane, defined as at least 6 uterine contractions in 60 minutes and at least: cervical dilation greater than or equal to 3cm dilated OR 80% effaced OR planned delivery by induction of labor or cesarean in no less than 24 hrs and no more than 7 days, for any indication as deemed necessary by the provider Received at least one dose of corticosteroid within twelve hours of enrollment Exclusion Criteria: Any prior antenatal corticosteroid course in current pregnancy Systemic corticosteroid administration during current pregnancy Fetal demise or known major fetal anomaly, including cardiac anomaly or hydrops Maternal contraindication to betamethasone: hypersensitivity reaction to any component of the medication, idiopathic thrombocytopenic, purpura, systemic fungal infection, or current use of amphotericin B Diabetes, pregestational or gestational Preexisting plan for intrapartum monitoring of maternal glucose levels for any reason Delivery expected within 12 hours of randomization, because of insufficient time for corticosteroids to confer benefit, including: Ruptured membranes with cervical dilation ≥ 3cm or with more than 6 contractions per hour unless Pitocin is deferred for at least 12 hours Chorioamnionitis Cervical dilation ≥ 8cm Evidence of non-reassuring fetal status requiring immediate delivery To ensure that there is an adequate proportion of women presenting at 34 to 35 weeks gestation, enrollment will be restricted so that no more than 50% of the women in the trial present at 36 weeks.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Neonatal Hypoglycemia | Newborn glucose level less than 40mg/dL | 48 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Corticosteroid, Betamethasone, Preterm Birth, Steroid