Study on Whether Tart Cherry Juice Can Reduce Oxidative Stress and Inflammation

Study Overview
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Brief Summary
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Oxidative stress has been linked to many diseases associated with aging, including coronary heart disease and Alzheimer's disease. Antioxidants and special proteins in the body work together to help prevent damage by free radicals. Some studies have indicated that as people age, they are less able to fight off oxidative stress and have increased levels of inflammation. Tart cherries are known to be rich in antioxidants and plant-nutrients. The product we are using in this study is an all-natural tart cherry juice, mixed with apple juice concentrate and containing no additives and no preservatives. We hope to learn whether antioxidant supplementation, such as tart cherry juice, can measurably decrease oxidative damage and inflammation associated with aging.

Detailed Description
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Objectives The primary objective of this pilot study is to investigate whether tart cherry juice consumption can reduce oxidative stress in older adults as measured by attenuation of F2-isoprostane responses to a forearm ischemia-reperfusion, and a decrease in urinary excretion products of oxidative damage. The secondary objective is to examine whether age-sensitive markers of inflammation are reduced in response to the cherry juice consumption.

Official Title
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Effects of Tart Cherry Juice on Oxidative Stress and Inflammation in Older Men and Women

Conditions
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Oxidative Stress, Antioxidant Capacity, Inflammation

Intervention / Treatment
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* Dietary Supplement: Tart Cherry Juice


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: men and women, ages 55-80y, in good health, with >8 years of education non-smoker able to give informed consent Exclusion Criteria: use of anti-oxidant supplements, in excess of a standard multi-vitamins current hormone replacement therapy any history of significant chronic disease uncontrolled hypertension body mass index (BMI) > 30 kg/m2 high physical activity level, as determined by questions on the screening questionnaire use of anti-inflammatory medication

Ages Eligible for Study
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Minimum Age: 55 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Dietary Supplement: Tart Cherry Juice|8 fl.oz. twice per day|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| plasma F2-isoprostane response to a forearm ischemia-reperfusion challenge. |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Urinary markers of oxidative damage. |  |  | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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oxidative stress, aging, ischemia-reperfusion