Effect of Different Exercises on Quality of Life of Leukemia Patients.

Study Overview
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Brief Summary
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To compare between modified strength training program and aerobic exercises on quality of life on children with Acute Lymphoblastic Leukemia. To compare between modified strength training program and aerobic exercises on functional capacity on children with Acute Lymphoblastic Leukemia.

Detailed Description
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This study will be done to determine any exercise from aerobic exercises or modified strength training program will be more effective on quality of life and functional capacity on children with Acute Lymphoblastic Leukemia .Acute Lymphoblastic Leukemia is wide spread in the world and the children with this disease are fragile so must know the most program effect.

Official Title
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Aerobic Training Versus Strength Exercises on Quality of Life and Functional Capacity on Children With Leukemia.

Conditions
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Exercise, Quality of Life, Acute Lymphoblastic Leukemia

Intervention / Treatment
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* Behavioral: Aerobic exercises
* Behavioral: Modified strength training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age range from8-12years. Children during 3rd phase( maintenance phase of the treatment). According San et al(2007) who found children with Acute Lymphoblastic Leukemia in maintenance phase of treatment can safely perform both aerobic and resistance training . Time elapsed since the start of the maintenance phase >20weeks. Children with muscle weakness due to chemotherapy. The height , weight and body mass index of the child will take on standard scale. preserved cardiac structure and function as assisted by echo-cardiogram. The children have ability to walk. Exclusion Criteria: Children who have one or more of the following criteria will be excluded from the study: Receiving more intensive chemotherapy. Mental disabled. Sever cardiomyopathy (ejection fraction <40%, ECG will be used as a pretest as it might be a more sensitive tool to exclude angina pectoris). Low blood platelet levels (< 50.000 per µl). Marked anemia (hemoglobin < 8 g/dl). Severe cachexia (i.e., weight mass loss > 35%). Pain in bone. Inability to walk. Sensory disturbance. Peripheral neuropathy.

Ages Eligible for Study
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Minimum Age: 8 Years
Maximum Age: 12 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Experimental controlled randomization using Block Stratified Randomized Software program, after obtaining informed consent from illegible patient or his caregiver.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Control group<br>Twenty five children who will not receive any physical therapy treatment. | |
| Experimental: Study group A<br>Twenty five children who will receive physical therapy treatment which include aerobic exercises. | Behavioral: Aerobic exercises<br>* Aerobic exercises will do by using treadmill for children of study group A. it will consist of (max.incline15% - max. speed - heart rate grips and wireless chest strap - smooth virtual fitness trainer - smooth drop folding frame - impression shock absorption cushioning system).<br>|
| Experimental: Study group B<br>Twenty five children who will receive physical therapy treatment which include modified strength training program. | Behavioral: Modified strength training<br>* Dumbbells will be used to conduct the modified strength training program for children of group B. This exercises included five exercises for the main muscle groups: bench press, leg press, seat row, leg extension and lat pull down.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Improvement of quality of life | The pediatric quality of life inventory (PedsQL) is a modular approach to measure health-related quality of life in healthy children and adolescents and those with acute and chronic health conditions. | at week 20 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Improvement of functional capacity | 6 minute walk test is a test to measure functional capacity by using pulse oximeter to detect percentage of oxygen saturation at peripheral capillaries. | at week 20 |