Variability of Heart Rate as a Marker of Complication of Colorectal Surgery

Study Overview
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Brief Summary
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Heart rate variability reflects the autonomic nervous system on the intrinsic activity of sinus node cells. Sympathetic hyperactivity is an adaptation to stress, while parasympathetic hyperactivity is present at rest. Thus, any variability in the heart frequency rate reflects variations in sympathetic and parasympathetic components in the autonomic nervous system. Failure to return to normal or a reduction in the variability of the heart rate in the postoperative period is correlated with complications in colorectal surgery.

Official Title
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Variability of Heart Rate as a Marker of Complication of Colorectal Surgery

Conditions
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Surgery--Complications

Intervention / Treatment
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* Diagnostic Test: Heart Rate Variability


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients operated for a scheduled colorectal resection due to cancer, diverticulitis, or Chronic Inflammatory Bowel Disease, American Society of Anesthesiologists score 1-2 The patient must have given their free and informed consent and signed the consent form The patient must be a member or beneficiary of a health insurance plan Exclusion Criteria: Patient taking antidepressants, antipsychotics, antihypertensive beta blocker type, anti-arythmic or oral contraception Uncontrolled diabetes or associated with a neuropathy Arrhythmias and conduction disturbances, , coronaropathy and heart failure, kidney failure Neuropathies Pacemaker or defibrillator The subject is participating in another interventional study, or is in a period of exclusion determined by a previous study The subject refuses to sign the consent It is impossible to give the subject informed information The patient is under safeguard of justice or state guardianship

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients undergoing colorectal surgery<br> | Diagnostic Test: Heart Rate Variability<br>* Heart rate and RR interval Post-anonymized analysis of heart rate variability using the KUBIOS software<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of variability of the heart rate between Day-1 to Day 7 | Measured by power spectral density; ratio of the high to low frequencies | Day 7 | 
| Correlation between the rate of variability of the heart rate between Day-1 to Day 7and anastomotic fistula diagnosed according to Center for Diseases Control criteria after scheduled colorectal surgery | Abdominal-pelvic imagery | Hospital discharge (maximum Day 7) | 
| Correlation between the rate of variability of the heart rate between Day-1 to Day 7 and peri-anastomotic fluid collections after scheduled colorectal surgery | Abdominal-pelvic imagery | Hospital discharge (maximum Day 7) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between the rate of variability of the heart rate between Day-1 to Day 7 and presence of intra abdominal abscess | diagnosed on CT-scan | Hospital discharge (maximum Day 7) | 
| Correlation between the rate of variability of the heart rate between Day-1 to Day 7 and presence of gut wall abscess |  | Hospital discharge (maximum Day 7) | 
| Correlation between the rate of variability of the heart rate between Day-1 to Day 7 and presence of pneumonia |  | Hospital discharge (maximum Day 7) | 
| Correlation between the rate of variability of the heart rate between Day-1 to Day 7 and presence of urinary tract infection |  | Hospital discharge (maximum Day 7) | 
| Correlation between the rate of variability of the heart rate between Day-1 to Day 7 and presence of central venous catheter infection |  | Hospital discharge (maximum Day 7) | 
| Correlation between the rate of variability of the heart rate between Day-1 to Day 7 and presence of intra abdominal hematoma |  | Hospital discharge (maximum Day 7) | 
| Correlation between the rate of variability of the heart rate between Day-1 to Day 7 and presence of hemorrhagic shock |  | Hospital discharge (maximum Day 7) | 
| Correlation between the rate of variability of the heart rate between Day-1 to Day 7 and death rate |  | Hospital discharge (maximum Day 7) | 
| Correlation between the rate of variability of the heart rate between Day-1 to Day 7 and presence of deep vein thrombosis |  | Hospital discharge (maximum Day 7) | 
| Correlation between the rate of variability of the heart rate between Day-1 to Day 7 and presence of pulmonary embolism |  | Hospital discharge (maximum Day 7) | 
| Correlation between the rate of variability of the heart rate between Day-1 to Day 7 and presence of acute pulmonary edema |  | Hospital discharge (maximum Day 7) | 
| Correlation between the rate of variability of the heart rate between Day-1 to Day 7 and presence of heart disease |  | Hospital discharge (maximum Day 7) |