The Role of Whey and Lupin in Glycemic Control (Nutritional Pre-Study)

Study Overview
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Brief Summary
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The study compared the acute effects of the supplementation of a standardized meal with either lupin or whey protein or no protein on the whole-body glucose and insuline metabolism.

Detailed Description
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The nutritional pre-study had the following key objectives: Primary objective: - Lupin protein lowers the postprandial blood glucose level equivalent to or to a greater extent than whey protein. Secondary objective: - Lupin protein has an equivalent or a stronger insulinotropic effect than whey protein.

Official Title
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Short-term Effects of Lupin Versus Whey Protein on Glucose and Insulin Responses to a Standardized Meal in a Randomized Controlled Trial

Conditions
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Whole Body Glucose and Insulin Metabolism

Intervention / Treatment
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* Dietary Supplement: Lupin Protein
* Dietary Supplement: Whey Protein
* Other: Reference


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Female and male volunteers Age: between 20 and 45 years Body mass index (BMI): 20-28 kg/m² Fasting blood glucose within normal ranges (70-99 mg/dl; 29-42 mmol/mol Hb) Glycated hemoglobin HbA1c within normal ranges (4-6%) Agreement and signed informed consent before the study Exclusion Criteria: Diabetes mellitus Increased bleeding tendency (hemophilia, regular use of anticoagulants) Allergy to nuts, legume or milk protein Drug, medication or alcohol abuse (frequent consumption of more than 20-30g alcohol/day) Intake of medication during the study Smoker Competitive athletes Extreme eating habits (vegan, special diets) Any other condition classed as unsuitable by the executive medical director

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Lupin Protein<br>Subjects received a test meal rich in carbohydrates and supplemented with lupin protein. | Dietary Supplement: Lupin Protein<br>* Subjects received a standardized test meal rich in carbohydrates and supplemented with lupin protein.<br>|
| Other: Whey Protein<br>Subjects received a test meal rich in carbohydrates and supplemented with whey protein. | Dietary Supplement: Whey Protein<br>* Subjects received a standardized test meal rich in carbohydrates and supplemented with whey protein.<br>|
| Other: Reference<br>Subjects received a test meal rich in carbohydrates not supplemented with any protein. | Other: Reference<br>* Subjects received a standardized test meal rich in carbohydrates and not supplemented with any protein.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood Glucose Metabolism by Blood Glucose and Serum Insulin (composite) |  | up to 180 minutes after the test meal was finished |