Changing and Understanding Motivation to Increase Physical Activity Among Sedentary Older Adults: Daily Activity Study of Health

Study Overview
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Brief Summary
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In this six-week behavioral intervention, sedentary older adults will receive daily health messaging via their smart phone to better understand their daily activities and emotions. Participants undergo structural and functional brain imaging before and after the intervention along with measures of their behavioral, emotional and thinking functions.

Detailed Description
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This project will obtain data on the effects of a six week intervention designed to increase subjects' motivation to increase their physical activity. Subjects will be randomized into two different conditions to examine the efficacy of self-affirmation + positive messaging versus a control group that receives negative messaging only on changes in physical activity. We will also examine whether any differential physical activity or structured exercise engendered in the two groups is maintained at 3 months post-intervention. Secondary outcome measures will include a battery of cognitive, psychosocial, and neuroimaging measures that are designed to explicate the mechanisms that underlie motivation effects for physical activity in sedentary older adults.

Official Title
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Changing and Understanding Motivation to Increase Physical Activity Among Sedentary Older Adults

Conditions
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Aging

Intervention / Treatment
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* Behavioral: Motivational MRI and Behavioral Intervention
* Behavioral: Control MRI and Behavioral Intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age range 60-95 Not exercising more than 150 minutes of moderate/vigorous intensity per week AND sitting more than 8 hours per day No contraindications to MRI (if opting for MRI) Being able to speak English fluently Body Mass Index (BMI) between 20 and 40 Normal or corrected-normal vision based on the minimal 20/20 standard Ambulatory without severe pain or the assistance of walking devices No diagnosis of a neurological disease Regular access to a computer with internet or smartphone Exclusion Criteria: Primary care physician does not approve additional physical activity Inability to ambulate without assistive device Any unstable medical condition Current diagnosis of a Diagnostic and Statistical Manual of Mental Disorders (DSM-V) Axis I or II disorder including Major Depression History of major psychiatric illness including schizophrenia (not including general anxiety disorder or depression) Current treatment for cancer - except non-melanoma skin Neurological condition (multiple sclerosis, Parkinson's disease, dementia, mild cognitive impairment) or brain injury (traumatic or stroke) Current alcohol or substance abuse Current treatment for congestive heart failure, angina, uncontrolled arrhythmia, deep vein thrombosis or other cardiovascular event Myocardial infarction, coronary artery bypass grafting, angioplasty or other cardiac condition in the past year Not passing the Telephone Interview of Cognitive Status (TICS) as normal Use of any anti-psychotic, anti-depressant, anti-anxiety, and attention deficit disorder (ADD/ADHD) medications.

Ages Eligible for Study
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Minimum Age: 60 Years
Maximum Age: 95 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Intervention<br>Brain MRI and Motivational Behavioral Intervention | Behavioral: Motivational MRI and Behavioral Intervention<br>* Motivational messaging delivered during a functional brain MRI scan and with daily messaging<br>|
| Active Comparator: Active control<br>Brain MRI and Control Behavioral Intervention | Behavioral: Control MRI and Behavioral Intervention<br>* Control messaging delivered during a functional brain MRI scan and with daily messaging<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Total step count (average steps/day) | This metric quantifies the change in the average number of steps taken each day, from the baseline period to the 6-week and 3-month followup periods. It is a marker of change in habitual ambulatory activity. | Baseline; 6-week; 3-month follow-up | 
| Sedentary behavior (average min/day) | This metric quantifies the change in the average amount of time spent sedentary each day, from the baseline period to the 6-week and 3-month follow-up periods. It is a marker of time spent inactive. | Baseline; 6-week; 3-month follow-up | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cognitive functioning | Executive function, complex attention and processing speed | Baseline; 6-week; 3-month follow-up | 
| Affective processing | Measure of affect and mood (i.e., geriatric depression scale) | Baseline; 6-week; 3-month follow-up | 
| Structural and functional imaging | Structural brain imaging will be used to measure brain morphology including cortical thickness, hippocampal subfields, and white matter structure. Functional brain imaging will be used to measure changes in brain activity at rest. | Baseline; 6-week; 3-month follow-up | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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motivation