The Effects of Altering Physical Activity on Cardiometabolic Health

Study Overview
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Brief Summary
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The effects of physical inactivity on variations in blood glucose and vascular health are not fully understood. The purpose of this study is to determine if an acute transition from physical activity to inactivity alters vascular health. Specifically, the investigators wish to examine in healthy, lean physically active individuals (obtaining greater than 10,000 steps/day) if decreasing physical activity (obtaining less than 5,000 steps/day) will alter blood flow following a meal a marker of vascular health. Furthermore, the investigators wish to examine if a one day return to physical activity (obtaining >10,000 steps/day) can restore the detrimental effects on blood flow following a meal.

Detailed Description
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Herein, we tested the hypothesis that an acute reduction in daily activity (from >10,000 to <5,000 steps/day) for 5 days in healthy individuals reduced meal-stimulated blood flow and if a 1 day return to activity improved this outcomes.

Official Title
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The Effects of Altering Physical Activity on Endothelial Function, Glycemic Control, and the Blood Flow Response to an Oral Glucose Tolerance Test.

Conditions
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Insulin Resistance

Intervention / Treatment
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* Behavioral: Exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: BMI: less than 30 kg/m2 Physically active: exercise greater than 60mins per week Exclusion Criteria: smoking type 2 diabetes Underlying conditions that limit ability to exercise safely Recent weight gain or loss(> 5% of body weight in 3 months) Recent (< 3 mo) changes in medication use or dose Pregnancy

Ages Eligible for Study
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Minimum Age: 19 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Exercise<br>5 days of inactivity followed by a 1 day return to physical activity | Behavioral: Exercise<br>* short period of inactivity (5 days) followed by a return to physical activity (1 day)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Effects of Physical Inactivity on Post Prandial Blood Flow | There was a pre-measurement period of 3 days, then 5 days of inactivity, followed by 1.5-2 days of return to activity. A 10 day time frame overall. Blood flow measured by Doppler ultrasound during an oral glucose tolerance test before and after 5 days of inactivity. | 10 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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insulin resistance, exercise, continuous glucose monitoring, blood flow, endothelial function