A New and Innovative Method for CO2 Removal in Anesthetic Circuits: Replacing Chemical Granulate

Study Overview
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Brief Summary
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CO2 removal is a mandatory part of modern anesthesia systems. Current chemical absorbers pose problems as the chemical granulate reacts not only with the CO2 but also the anesthetic drugs, producing organ toxic substances. The proposed CO2 absorber provides a solution to the problem of organ-toxin production in anesthetic circuits.

Detailed Description
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CO2 removal is a mandatory part of modern anesthesia systems. Current chemical absorbers pose problems as the chemical granulate reacts not only with the CO2 but also the anesthetic drugs, producing organ toxic substances. The proposed CO2 absorber provides a solution to the problem of organ-toxin production in anesthetic circuits. This new absorber can be easily integrated into any anesthesia circuit, and can effectively remove CO2 without reacting with anesthetic drugs, thus eliminating organ-toxic by-products. It uses advanced membrane technology to separate gas flows within the circuit, separating the expensive anesthetic vapors from the CO2 (the main by-product of metabolism). Anesthetic vapors thus remain in the closed loop circuit, while CO2 is separated and exhausted to the atmosphere, rather than being absorbed through a chemical reaction.

Official Title
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A New and Innovative Method for CO2 Removal in Anesthetic Circuits: Replacing Chemical Granulate

Conditions
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End Tidal CO2, CO2 Removal

Intervention / Treatment
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* Device: memsorb


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: American Society of Anesthesiology Physical Status Class I, II, III (low-medium risk patient) English-speaking patients Scheduled for elective surgery Length of anesthesia ≥ 60 minutes Exclusion Criteria: Pregnant American Society of Anesthesiology Physical Status Class IV (high risk patient) Patients schedule for emergency surgery Known respiratory disease, including COPD and severe asthma Have elevated pressure in your brain (intra cranial pressure, ICP)
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Control<br>Control - Observational (non interventional) data is collected from current state of the art absorber devices. | |
| Experimental: memsorb<br>New CO2 filter - data is collected using the new CO2 absorber. | Device: memsorb<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| End tidal CO2 level | After completion of the surgery, the digital respiration records are exported from the hospital database. End tidal CO2 is assessed as either in range [4.1-5.6]% or out of range <4.1% or >5.6%. | Continuous (5min intervals) over duration of anesthesia. No data collection prior or post anesthesia. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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CO2 filter, anesthesia, device