Observational Study to Assess Natural History in Cockayne Syndrome Patients

Study Overview
=================
Brief Summary
-----------------
This is an Observational Study of children under the age of 11 diagnosed with Cockayne Syndrome to assess the natural progression of Cockayne Syndrome disease, with special attention to hearing and physical changes in length or height, weight, head circumference, and arm span during standard treatment. The primary analytical objective is to determine the rate of linear growth over a 6-month period in children < 2 years of age and over a 12-month period in children ≥ 2 years of age.

Official Title
-----------------
An Observational Study to Assess the Natural History Including Growth and Hearing in Patients With Cockayne Syndrome

Conditions
-----------------
Cockayne Syndrome

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Pediatric patients with a documented diagnosis of CS, as suggested by clinical features and possible confirmation by genetic consultation and analysis Age of participation: At least 12 months of age at the time of signing Informed Consent/Assent Female patient's age will not be greater than 10 years of age at the time of signing Informed Consent/Assent Male patient's age will not be greater than 11 years of age at the time of signing Informed Consent/Assent Exclusion Criteria: Severe contractures or physical deformities that in the opinion of the investigator would prevent accurate measurement of height, length and ulna length Patients that have taken growth hormone or growth hormone related medications within 12 months prior to the date of Informed Consent/Assent Known history of inborn error of hyperprolinemia (Type I or Type II) Clinical features present at the time of initial screening that are associated with the terminal phases of the natural progression of CS suggesting safe travel and completion of the study and its assessments to be unlikely as judged by the Investigator, including any of the following: Continuous or intermittent dependence on supplemental oxygen at home during the prior six months Two or more hospitalizations for pneumonia during the prior 12 months; A documented net weight loss of at least 10%, which has not been recovered and which includes a significant net weight loss (beyond the estimated error of the measurement) over the most recent 6 months, despite intensive nutritional support including the use of gastrostomy tube feedings Presence of scoliosis with a Cobb's angle of 30º or greater

Ages Eligible for Study
-----------------
Minimum Age: 1 Year
Maximum Age: 11 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The primary objective is to determine the rate of linear growth over a 6-month period in children < 2 years of age and over a 12-month period in children ≥ 2 years of age. |  | 6 -12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hearing Test Results tabulated and with the severity/deficits to be correlated with patient age, height velocity, and Pediatric Evaluation of Disabilities Inventory (PEDI)Score |  | 6-12 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Cockayne Syndrome, pediatrics, growth, hearing, Ageing