Comparing Brain Images Before and After MRI-upgrade - TimFit Upgrade Study

Study Overview
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Brief Summary
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In the Ghent University, an upgrade of the MRI-scanner used for research from Siemens Trio Tim to Siemens Prisma Fit is planned in the near future. As a change of MRI hard- and software might influence brain images, it is necessary to evaluate the images before and after the upgrade.

Official Title
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Brain Images Before and After Upgrade of the MRI-scanner (Siemens Tim TRIO vs Siemens PRISMA FIT) - The TimFit Study

Conditions
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Neuroimaging, Quality Control

Intervention / Treatment
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* Device: Magnetic Resonance Imaging


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy volunteer Exclusion Criteria: Protheses or artificial implants, no magnetic or metal parts in the body Being pregnant or breastfeeding Having claustrophobia

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Healthy volunteers<br>six healthy volunteers: 3 male (age 20-40; 40-60 and 60+) and 3 female (age 20-40; 40-60 and 60+) | Device: Magnetic Resonance Imaging<br>* Brain imaging using magnetic resonance imaging, using several MRI sequences: structural imaging (grey matter, using T1-imaging), cerebral perfusion using arterial spin labeling), functional and effective connectivity (using resting-state functional MRI), white matter tracts (using diffusion imaging), white matter lesions (using Fluid-attenuated inversion recovery MRI (FLAIR)) and microbleeds (using Susceptibility weighted imaging (SWI))<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in grey matter volume before versus after MRI-upgrade |  | 7 months, 4 scan sessions of max 1 hour | 
| Change in cerebral perfusion (ml/100g/min) using Arterial Spin Labeling before versus after MRI-upgrade |  | 7 months, 4 scan sessions of max 1 hour | 
| Change in arterial transit times before versus after MRI-upgrade |  | 7 months, 4 scan sessions of max 1 hour | 
| Change in functional connectivity (fc) using Resting State functional MRI before versus after MRI-upgrade |  | 7 months, 4 scan sessions of max 1 hour | 
| Change in effective connectivity using resting state functional MRI before versus after MRI-upgrade |  | 7 months, 4 scan sessions of max 1 hour | 
| Change in white matter diffusion before versus after MRI-upgrade |  | 7 months, 4 scan sessions of max 1 hour | 
| Difference in image quality of FLAIR image before versus after MRI-upgrade |  | 7 months, 4 scan sessions of max 1 hour | 
| Difference in image quality of SWI image before versus after MRI-upgrade |  | 7 months, 4 scan sessions of max 1 hour |