Effect of Whole-Body Vibration on Plasma Sclerostin Level

Study Overview
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Brief Summary
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The aim of this study is to investigate effect of whole-body vibration on plasma sclerostin level in healthy young adult women. Fifteen healthy young adult women are planned to include in this study. All cases will be trained on a whole-body vibration (WBV) platform (Power Plate) 5 times a week for one week period. Training duration will be short at the beginning but progressed slowly. The amplitude of vibration will be 2 mm and the frequency of the vibration will be 40 Hz. The subjects will be asked to report negative side effects or adverse reactions in their training diary. Previbration and postvibration (just after, 10.minute and 30.minute) levels of plasma sclerostin will be measured on first, second and fifth day of experiment. Sclerostin levels will be measured by human sclerostin ELISA kit.

Detailed Description
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Whole-body vibration has a strong osteogenic effect. The cyclic mechanical loading to the bone stimulates the osteocytes. Sclerostin, the protein product of the SOST gene, is an osteocyte-specific cysteine knot-secreted glycoprotein that is a potent inhibitor of bone formation. Sost/sclerostin levels have been reported to be reduced by mechanical stimulation. The aim of this study is to investigate effect of whole-body vibration on plasma sclerostin level in healthy young adult women.

Official Title
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Effect of Whole-Body Vibration on Plasma Sclerostin Level in Healthy Young Adult Women

Conditions
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Osteopenia

Intervention / Treatment
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* Device: whole-body vibration (WBV)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy women, Women with ages varying between 20 and 40 years Right-handed women Exclusion Criteria: Lower extremity problems Orthopedic problems: shortness of legs, congenital anomalies, etc. Joint disease (arthritis, joint prosthesis, etc.) Other painful pathologies in the lower extremities (fractures, tendinitis,bursitis, etc.) Circulation problems in the lower extremities Dorsolumbar diseases: Vertebral fract, disc hernias, spondylodiskitis, etc. Systemic disease cases Systemic bone disease: osteoporosis, osteomalacia, Paget's disease Hypertension (>135 mmHg systolic, >85 mmHg diastolic) Heart dis.(coronary dis, conduction/rhythm prob, cardiac pacemaker) Infectious diseases Endocrine diseases (Diabetes mellitus etc) Neurological diseases (CNS problems, peripheral neuropathy) Menstrual cycle disorders, amenorrhea, lactation, oral contraceptive use Cases during the ovulatory period (11-16th day of menses) Obesity (BMI >30 kg/m2) or low BMI (BMI <20 kg/m2) Vertigo Cognitive function disorders Women whose blood samples were not taken in the time planned Women whose blood samples hemolyzed

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Training<br>The whole-body vibration (WBV) training | Device: whole-body vibration (WBV)<br>* All cases will be trained on a whole-body vibration (WBV) platform (Power Plate) 5 times a week for one week period.<br>* Other names: Cyclic mechanical loading;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Plasma Sclerostin Level | Change of plasma sclerostin level with whole-body vibration | 1 month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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sclerostin, whole-body vibration