The Influence of Antiphospholipid Antibodies on the Relationship Between Hyperurecemia, Gout and Metabolic Syndrome

Study Overview
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Brief Summary
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Patients with hyperuricemia were confirmed to have higher risks of cardiovascular disease, but the exact mechanism remained to be elucidated. Many connective tissue diseases such as rheumatoid arthritis are often associated with antiphospholipid antibodies-associated endothelial impairment. In the present study, the investigators will analyze the presence of antiphospholipid antibodies in the serum of the patients with gout/asymptomatic hyperuricemia, with a comparison to the patients of osteoarthritis but without hyperuricemia and gout. The investigators expect to find a correlation between these pathogenic antibody and those cardiovascular co-morbidities.

Detailed Description
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Patients with hyperuricemia were confirmed to have higher risks of cardiovascular disease, but the exact mechanism remained to be elucidated. Many connective tissue diseases such as rheumatoid arthritis are often associated with antiphospholipid antibodies-associated endothelial impairment. In the present study, we'll analyze the presence of antiphospholipid antibodies in the serum of the patients with gout/ asymptomatic hyperuricemia, with a comparison to the patients of osteoarthritis but without hyperuricemia and gout. We expect to find a correlation between these pathogenic antibody and those cardiovascular co-morbidities. Patient eligibility： Patients with gout Patients with asymptomatic hyperuricemia Patients of osteoarthritis but without hyperuricemia and gout Exclusion Criteria： Patients younger than 20 years old

Official Title
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The Influence of Antiphospholipid Antibodies on the Relationship Between Hyperurecemia, Gout and Metabolic Syndrome

Conditions
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Antiphospholipid Syndrome, Endothelial Dysfunction, Hyperuricemia, Gout, Metabolic Syndrome

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient with gouty arthritis Patient with asymptomatic hyperurecemia Patient of osteoarthritis but without hyperuricemia and gout Exclusion Criteria: 1.Patient younger than 20 y/o.

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Gouty arthritis<br>Patient with gouty arthritis | |
| Asymptomatic hyperuricemia<br>Patient with asymptomatic hyperuricemia | |
| OA without hyperuricemia<br>Patient of osteoarthritis but without hyperuricemia and gout | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| development of metabolic syndrome or cardiovascular events |  | 36 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Acute myocardial infarct or stroke |  | 36 months or more | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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antiphospholipid syndrome, gouty arthritis, Hyperuricemia, metabolic syndrome, osteoarthritis, cardiovascular co-morbidities