Low Creatinine Level and Respiratory Failure

Study Overview
=================
Brief Summary
-----------------
Low creatinine levels may be a sign of muscle atrophy or weakness, and therefore predictive for respiratory insufficiency in the Intensive care unit (ICU) patients. The investigators compared the outcomes of participants with low creatinine levels with subsequent ICU participants admitted into ICU in the tertiary hospital.

Detailed Description
-----------------
The investigators have found a total of 46 participants with low creatinine levels and compared their outcome data with a group of participants with normal or high creatinine levels (control group, N=61). Low creatinine was defined as values of ≤40 μmol/L. Demographic data, type of admission (medical vs. surgical), hemoglobin values, CRP, and ventilator days were compared. A statistical analysis was performed using chi square and T-test.

Official Title
-----------------
A Correlation of Low Serum Creatinine Levels and Respiratory Function in the Mechanically Ventilated Patients in the Intensive Care Unit

Conditions
-----------------
Intensive Care Unit, Respiratory Insufficiency, Muscle Weakness

Intervention / Treatment
-----------------
* Diagnostic Test: Serum creatinine levels


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Inclusion criteria for study group was value of ≤40 µmol/L serume creatinine level during hospitalization in ICU from July 2015 to November 2016. Exclusion Criteria: Patients who were younger than 18 years

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Study group<br>Total of 46 patients with low serum creatinine levels whose values were obtained from the central laboratory with inclusion criteria (< 40mmol/L) | Diagnostic Test: Serum creatinine levels<br>* Comparison of treatment length using mechanical ventilaton, length of stay in ICU, survival between two groups<br>|
| Control group<br>A total of 61 consecutive patients were obtained who were treated in ICU CHC Osijek, according to the date of admission. | Diagnostic Test: Serum creatinine levels<br>* Comparison of treatment length using mechanical ventilaton, length of stay in ICU, survival between two groups<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Length of mechanical ventilation treatment in group with low serume creatinine level | The investigators compared length of mechanical ventilation treatment between group with low serume creatinine level and control group | Through study completion, an average of 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Length of stay in ICU in group with low serume creatinine level | The investigators compared length of stay in ICU between group with low serume creatinine level and control group | Through study completion, an average of 1 year | 
| White blood cell values in group with low creatinine level | The investigators compared white blood cell values between group with low creatinine level and control group | Through study completion, an average of 1 year | 
| Hemoglobine values in group with low creatinine level | The investigators compared hemoglobine values between group with low creatinine level and control group | Through study completion, an average of 1 year | 
| Number of patients who started nutrition in ICU | The investigators compared number of patients between group with low creatinine level and control group who started nutrition in ICU | Through study completion, an average of 1 year | 
| Platelets values in group with low creatinine level | The investigators compared platelet values between group with low creatinine level and control group | Through study completion, an average of 1 year | 
| Number of patients who receive blood products transfusion | The investigators compared number of patients who received blood products between group with low creatinine level and control group | Through study completion, an average of 1 year | 
| Number of patients discharged | The investigators compared number of patients who were discharged from intensive care unit to the ward between group with low creatinine level and control group | Through study completion, an average of 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Low serume creatinine levels, respiratory insufficiency, ICU