Brain and Cognitive Reserve

Study Overview
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Brief Summary
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Ischemic strokes are one of the leading causes of handicap and death in elderly people in France. Cognitive reserve (CR) is an active model, defined as a function of lifetime intellectual activities and other environmental factors that explain differential susceptibility to functional impairment in the presence of pathology or other neurological insult. CR is estimated using variables for cognitive activity: years of education, professional status, socioeconomic status… Furthermore, brain reverse (BR) is a passive and quantitative model that depend on brain size and other quantitative aspects of the brain that explain differential susceptibility to functional impairment in the presence of pathology. Firstly, volume and localization of ischemic strokes have a great impact on CR and BR due to brain injury. On the other hand, CR influences the severity and the expression of cognitive diseases. The investigators realize a prospective study in order to assess the impact of CR and BR on cognitive prognosis after a right middle cerebral artery ischemic stroke in elderly patients.

Official Title
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Neuro-anatomical Correlates on Volumetric MRI on the Impact of Brain Reserve and Cognitive Reserve on Ischemic Strokes in Elderly

Conditions
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Brain Ischemia

Intervention / Treatment
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* Other: neurologic and neuropsychological evaluation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ≥70 years old right middle cerebral artery ischemic stroke hospitalized in neurovascular unit of Pierre Wertheimer hospital between January 2015 to January 2016 Exclusion Criteria: Contraindication for MRI Hemorrhagic stroke Aphasia

Ages Eligible for Study
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Minimum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: neurologic and neuropsychological evaluation<br> | Other: neurologic and neuropsychological evaluation<br>* cognitive prognosis, cognitive reserve, brain volume will be studied on patients with scale, questionnaire, magnetic resonance imaging<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| evaluation of cognitive prognosis | measure will be performed with the Mattis dementia rating scale | one year post Ischemic stroke | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Volume of leucoencephalopathy | measure will be performed with a MRI | one year post Ischemic stroke | 
| volume of hippocampic | measure will be performed with a MRI | one year post Ischemic stroke | 
| brain injury | measure will be performed with a MRI | one year post Ischemic stroke | 
| volume of ischemic stroke | measure will be performed with a MRI | one year post Ischemic stroke | 
| evaluation of cognitive reserve | measure will be performed with the Cognitive reserve index questionnaire | one year post Ischemic stroke | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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ischemic stroke, brain reserve, cognitive reserve, cognitive prognosis