Screening of Specific Genes for Pigmented Villous Nodular Synovitis

Study Overview
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Brief Summary
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This study retrospectively analyzed the history of present illness of PVNS patients in our hospital. The enrolled patients were followed up by telephone to follow up their postoperative recovery and living conditions. Take the patient's pathological specimens for immunohistochemical testing, evaluate the relationship between the expression of different molecular targets, clinical manifestations and patient prognosis, and explore new molecular targets related to disease diagnosis and treatment.

Detailed Description
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This study retrospectively analyzed the symptoms, time of onset, injury history, laboratory examinations, imaging examinations, and intraoperative conditions of PVNS patients in our hospital. The enrolled patients were followed up by telephone to follow up their postoperative recovery and living conditions (VAS score, SF-36 score). Take the patient's pathological specimens for immunohistochemical testing, evaluate the relationship between the expression of different molecular targets, clinical manifestations and patient prognosis, and explore new molecular targets related to disease diagnosis and treatment.

Official Title
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Screening of Specific Genes for Pigmented Villous Nodular Synovitis

Conditions
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Pigmented Villonodular Synovitis

Intervention / Treatment
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* Procedure: Arthroscopic synovectomy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Clinical diagnosis of pigmented villonodular synovitis. Clinical diagnosis of giant cell tumor of tendon sheath Exclusion Criteria: No surgical treatment. There were no pathological specimens during the operation. The age of the patient is less than 18 years old or more than 60 years old. The operation record shows nodular type.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Arthroscopic synovectomy|Arthroscopic synovectomy|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Difference of scale score between immunohistochemistry positive group and negative group | Difference of Visual Analog Score for pain between CSF-1 immunohistochemistry positive group and negative group | One week after surgery | 
| Difference of Visual Analog Score for pain between TNF-α immunohistochemistry positive group and negative group | Difference of Visual Analog Score for pain between TNF-α immunohistochemistry positive group and negative group | One week after surgery | 
| Difference of Visual Analog Score for pain between IL-1B immunohistochemistry positive group and negative group | Difference of Visual Analog Score for pain between IL-1B immunohistochemistry positive group and negative group | One week after surgery | 
| Difference of SF-36 score between CSF-1 immunohistochemistry positive group and negative group | Difference of SF-36 score between CSF-1 immunohistochemistry positive group and negative group | One week after surgery | 
| Difference of SF-36 score between TNF-α immunohistochemistry positive group and negative group | Difference of SF-36 score between TNF-α immunohistochemistry positive group and negative group | One week after surgery | 
| Difference of SF-36 score between IL-1B immunohistochemistry positive group and negative group | Difference of SF-36 score between IL-1B immunohistochemistry positive group and negative group | One week after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between basic demographic characteristics and scale scores | Correlation between age, gender and scale score | One week after surgery |