Atorvastatin for Prevention of Postoperative Atrial Fibrillation After Off-Pump Coronary Artery Bypass Grafting Surgery

Study Overview
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Brief Summary
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The purpose of this study is to determine whether pretreatment with atorvastatin protects against atrial fibrillation following off-pump coronary artery bypass graft surgery.

Detailed Description
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Atrial fibrillation after cardiac surgery is the most common arrhythmic complication that may increase incidence of congestive heart failure, renal insufficiency, and stroke, which increase the length of hospital stay, the rates of re-hospitalization, and cost of care. Its pathogenesis is multifactorial, and its prevention and management remain suboptimal. Recently, observational evidence has suggested that patients who have undergone previous statin therapy have a lower incidence of postoperative atrial fibrillation. The purpose of this study is to determine whether pretreatment with atorvastatin protects against atrial fibrillation following off-pump coronary artery bypass graft surgery.

Official Title
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The Effects of Atorvastatin on the Occurrence of Postoperative Atrial Fibrillation After Off-Pump Coronary Artery Bypass Grafting Surgery

Conditions
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Coronary Artery Bypass

Intervention / Treatment
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* Drug: atorvastatin


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: consecutive patients scheduled for the elective off-pump CABG surgery Exclusion Criteria: prior statin use previous episodes of atrial fibrillation impaired renal function with serum creatinine >2mg/dL serum aspartate aminotransferase or alanine aminotransferase concentrations more than 3 times the upper limit of normal a malignancy or inflammatory disease
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>Atorvastatin group | Drug: atorvastatin<br>* atorvastatin 20 mg/d, started 3 days before surgery<br>|
| No Intervention: 2<br>Control group | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the development of postoperative in-hospital atrial fibrillation confirmed by 12-lead ECG |  | in-hospital period | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| major adverse cardiac and cerebrovascular events rate, including cardiovascular death, postoperative stroke, myocardial infarction, or persistent atrial fibrillation,and identification of predictive markers for postoperative atrial fibrillation |  | 30 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Off-pump coronary artery bypass graft, Atorvastatin, Postoperative atrial fibrillation