Effects of Peanut Consumption on Postprandial Inflammation, Glucose and Triglycerides

Study Overview
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Brief Summary
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This pilot study will investigate the effects of acute peanut consumption on markers of inflammation, triglycerides and glucose. The hypothesis is that a high glucose/SFA meal will increase postprandial production of the inflammatory marker, C-reactive protein (CRP), and that the addition of peanuts to the control meal will reduce the production of CRP, as well as triglycerides and glucose.

Detailed Description
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Previous research has demonstrated that a single meal high in saturated fatty acids (SFA) and glucose can induce increases in IL-6, TNF-α and CRP in abdominally obese and diabetic subjects. As over two-thirds of the U.S. population is overweight or obese, it is important to identify foods that can attenuate postprandial increases in lipids, glucose and inflammation in this population. Therefore, the purpose of the pilot study is to determine whether a high SFA / high glucose control meal will induce an acute inflammatory response in overweight individuals, and whether the addition of peanuts to this meal will ameliorate this response. To ensure that these effects are due to peanuts, and not to the increase in total fat, we will compare this response to another test meal that includes an oil blend with a similar fatty acid composition to peanuts.

Official Title
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Pilot Study of the Effect of Peanut Consumption on Postprandial Inflammatory Status, Glucose and Triglycerides

Conditions
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Cardiovascular Disease

Intervention / Treatment
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* Dietary Supplement: Peanuts
* Dietary Supplement: Glucose and whipping cream
* Dietary Supplement: Oil Blend


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: BMI >28 LDL_C below 130 mg/dl TG below 350 mg/dl Blood pressure within normal ranges (below 140/90 mmHg) Exclusion Criteria: Smoking Allergies to peanuts or dairy products Known intolerance for high fat meals History of CVD, kidney disease, diabetes or inflammatory disease Use of non-steroidal anti-inflammatories or immunosuppressants Conditions requiring the use of steroids Use of medication or supplements for elevated lipids, blood pressure or glucose

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Control<br>Shake containing heavy whipping cream, glucose and chocolate syrup | Dietary Supplement: Glucose and whipping cream<br>* An oral liquid glucose (75g) and fat (high saturated fat from 60g heavy whipping cream) load. Chocolate syrup is added for flavor.<br>|
| Experimental: Peanut<br>Shake containing control (whipping cream, glucose and chocolate syrup) + 3oz of peanuts | Dietary Supplement: Peanuts<br>* Shake containing 3.0oz of peanuts (including skin) + control (heavy whipping cream, glucose and chocolate syrup)<br>|
| Experimental: Oil blend<br>Shake containing control (heavy whipping cream, glucose and chocolate syrup) + oil blend (equivalent to fatty acids provided in 3oz peanuts) | Dietary Supplement: Oil Blend<br>* Shake containing an oil blend (sunflower, sesame, olive and palm oils) + control (heavy whipping cream, glucose and chocolate syrup). The amount of oil added to the control will provide an equivalent amount of fat to that provided in 3 oz (85g) of peanuts<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Serum C-reactive protein |  | 0min | 
| Serum C-reactive protein |  | 60 min | 
| Serum C-reactive protein |  | 120 min | 
| Serum C-reactive protein |  | 240 min | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Serum Glucose |  | 0 min | 
| Serum Insulin |  | 0 min | 
| Serum Triglycerides |  | 0 min | 
| Serum Glucose |  | 60 min | 
| Serum Glucose |  | 120 min | 
| Serum Glucose |  | 240 min | 
| Serum Insulin |  | 60 min | 
| Serum Insulin |  | 120 min | 
| Serum Insulin |  | 240 min | 
| Serum Triglycerides |  | 60 min | 
| Serum Triglycerides |  | 120 min | 
| Serum Triglycerides |  | 240 min | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Obese, Overweight