The Acute Effect of Interval-walking

Study Overview
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Brief Summary
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Four months of interval walking training (IWT) is superior to energy-expenditure matched continuous walking training (CWT) with regards to weight loss and improvements in glycemic control. The reason for this is unclear. One potential explanation for the differential outcome in weight loss is excess post-exercise oxygen consumption (EPOC), which is defined as the elevated oxygen consumption measured during the hours following an exercise bout. A large EPOC means greater energy expenditure which, if energy intake does not change, leads to a greater weight loss. This weight loss may subsequently improve glycemic control Aim 1: To assess the effect of an acute bout of IWT vs. an acute bout of CWT on glycemic control in type 2 diabetics and to assess mechanisms responsible for differences (if any). It is hypothesised that IWT will be more advantageous for improving glycemic control. Aim 2: To examine the effect of an acute bout of IWT vs. an acute bout of CWT on EPOC. It is hypothesised that IWT will produce an EPOC of larger magnitude than CWT.

Official Title
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The Acute Effect of Interval-walking

Conditions
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Type 2 Diabetes Mellitus

Intervention / Treatment
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* Behavioral: Interval Walking
* Behavioral: Continuous walking


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diabetes mellitus, type 2 Exclusion Criteria: Smoking Pregnancy insulin dependence Contraindication to physical activity (as judged by medical history and screening) Evidence of thyroid, liver, lung, kidney or heart disease

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Control<br>No exercise (control experiment) | |
| Experimental: Interval Walking<br>A one hour interval walking exercise bout | Behavioral: Interval Walking<br> <br> * Other names: Interval training;|
| Experimental: Continuous walking<br>A one hour continuous walking exercise bout | Behavioral: Continuous walking<br> <br> * Other names: Continuous training;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Glycemic control | Glycemic control will be assessed after a one hour specific exercise intervention (control/continuous walking/interval walking) in a controlled setting (a mixed meal tolerance test). Moreover, glycemic control will be assessed during the following 2 days in a free-living environment, using continuous glucose monitoring systems. | Will be assessed immediately after the intervention using a mixed meal tolerance test (duration: 5 hours) followed by continuous glucose monitoring (duration: 48 hours). | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Excess post-exercise oxygen consumption (EPOC) | EPOC will be assessed during the hours following the before-mentioned specific exercise bouts using the indirect calorimetry ventilated hood technique. | Will be assessed immediately after the intervention using a ventilated hood (duration: 5 hours). | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Glycemic control, excess post-exercise oxygen consumption