Laser Therapy on Orthodontic Tooth Movement

Study Overview
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Brief Summary
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The aims of this study will be to evaluate if a Lower Level Laser Therapy (LLLT): (1) enhances the levels of important pro-inflammatory chemokines involved in the bone remodeling process; (2) increases the rate of orthodontic tooth movement (OTM) on human subjects.

Official Title
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The Effects of Lower Level Laser Therapy on Orthodontic Tooth Movement

Conditions
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Laser Therapy, Orthodontic Tooth Movement, Bone Remodeling

Intervention / Treatment
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* Device: Low-level Laser Therapy
* Procedure: Orthodontic force


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Facial convexity Protrusion or biprotrusion of the incisors Dental crowding Healthy periodontal condition Satisfactory oral hygiene Exclusion Criteria: Patients under medications that may interfere with bone metabolism, such as anti-inflammatory, antibiotics and hormonal supplements in the previous three months Skeletal crossbite Parafunctional habits Occlusal interference

Ages Eligible for Study
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Minimum Age: 13 Years
Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Low-level laser therapy and no orthodontic force<br>No orthodontic force. Laser is applied on the first day and the premolars is extracted after 24 hours | Device: Low-level Laser Therapy<br>* Low-level laser therapy is applied on premolars that will be extracted for treatment plan reasons<br>|
| Experimental: Low-level laser therapy and application of orthodontic force<br>Orthodontic force and Laser is applied on the first day and the premolars is extracted after 24 hours | Device: Low-level Laser Therapy<br>* Low-level laser therapy is applied on premolars that will be extracted for treatment plan reasons<br>Procedure: Orthodontic force<br>* Mechanical loading is applied on premolars that will be extracted for treatment plan reasons and in canines for tooth movement<br>|
| Active Comparator: Orthodontic force only<br>Orthodontic force is applied and the premolars is extracted after 24 hours, with no laser therapy | Procedure: Orthodontic force<br>* Mechanical loading is applied on premolars that will be extracted for treatment plan reasons and in canines for tooth movement<br>|
| Experimental: Low-level laser therapy and orthodontic force<br>Orthodontic force and Laser is applied and the orthodontic tooth movement is evaluated | Device: Low-level Laser Therapy<br>* Low-level laser therapy is applied on premolars that will be extracted for treatment plan reasons<br>Procedure: Orthodontic force<br>* Mechanical loading is applied on premolars that will be extracted for treatment plan reasons and in canines for tooth movement<br>|
| Active Comparator: Orthodontic force with no laser therapy<br>Orthodontic force is applied and the orthodontic tooth movement is evaluated, with no laser therapy | Procedure: Orthodontic force<br>* Mechanical loading is applied on premolars that will be extracted for treatment plan reasons and in canines for tooth movement<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of orthodontic tooth movement, with and without low-level laser therapy | The canine retraction was measured with a digital dynamometer | The quantification of OTM was performed before canine retraction | 
| Rate of orthodontic tooth movement, with and without low-level laser therapy | The canine retraction was measured with a digital dynamometer | The quantification of OTM was performed after 1 month of canine retraction | 
| Rate of orthodontic tooth movement, with and without low-level laser therapy | The canine retraction was measured with a digital dynamometer | The quantification of OTM was performed after 2 months of canine retraction | 
| Rate of orthodontic tooth movement, with and without low-level laser therapy | The canine retraction was measured with a digital dynamometer | The quantification of OTM was performed after 3 months of canine retraction | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Chemokine levels in the periodontal tissue after LLLT and orthodontic force | The chemokine levels were measured in the periodontal tissue after LLLT and orthodontic force by means of a cytometric bead array (CBA) | The chemokine levels were assayed on days 0, 1, 7 and 14 after application of orthodontic force and low-level laser therapy | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Low-Level Light Therapy, Tooth Movement, Bone Remodeling