Atrial Fibrillation and Carotid Atherosclerosis in Ischemic Stroke Patients-(AFCAS)

Study Overview
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Brief Summary
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The main aim of the study is to investigate the prevalence and characteristics of ischemic stroke patients with atrial fibrillation and concurrent carotid atherosclerosis. Additionally, this study will investigate the effect of concurrent carotid atherosclerosis on the outcomes of recurrent stroke, myocardial infarction and death during follow-up

Official Title
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Carotid Artery Atherosclerosis in Ischemic Stroke Patients With Atrial Fibrillation.(Atrial Fibrillation and Carotid Atherosclerosis in Ischemic Stroke Patients- AFCAS)

Conditions
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Ischemic Stroke, Atrial Fibrillation, Carotid Stenosis

Intervention / Treatment
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* Biological: Carotid Stenosis


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Hospitalization due to ischemic stroke Atrial fibrillation Αny type of carotid vascular imaging Exclusion Criteria: Intracerebral haemorrhage on admission Haemorrhagic transformation on admission
Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with Carotid stenosis<br>Ischemic stroke patients with atrial fibrillation and carotid stenosis | Biological: Carotid Stenosis<br>* To investigate if the concurrent presence of carotid stenosis has any effect on future outcomes of patients with ischemic stroke and atrial fibrillation<br>|
| Patients without Carotid stenosis<br>Ischemic stroke patients with atrial fibrillation without carotid stenosis | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Stroke recurrence |  | From date of randomization until the date of stroke recurrence, assessed up to 60 months | 
| Myocardial infarction |  | From date of randomization until the date of myocardial infarction, assessed up to 60 months | 
| Death during follow-up |  | From date of randomization until the date of death from any cause, assessed up to 60 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| modified Rankin Scale at 3 months | mRS: modified Rankin Scale; 0=No symptoms at all; 1=No significant disability despite symptoms: able to carry out all usual duties and activities; 2=Slight disability: unable to carry out all previous activities, but able to look after own affairs without assistance; 3= Moderate disability: requiring some help, but able to walk without assistance; 4=Moderately severe disability: unable to walk without assistance and unable to attend to own bodily needs without assistance; 5=Severe disability: bedridden, incontinent and requiring constant nursing care and attention; 6=Dead | 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Ischemic Stroke, Atrial fibrillation, carotid stenosis, atherosclerosis