Anemia of Prematurity and Hemodynamics

Study Overview
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Brief Summary
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The aim of this work to study the hemodynamic changes accompanying anemia of prematurity in neonates with gestational age ≤32 weeks and the effect of its treatment on hemodynamics.

Detailed Description
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This prospective observational study aims to evaluate the hemodynamic changes provoked by anemia of prematurity and transfusion of packed red blood cells (RBCs). Nonanemic inpatient premature infants (Hematocrit>30%) will be compared with pretransfusional anemic inpatient premature infants. Anemic premature infants will be assessed before and 24 hours after the transfusion of pRBCs. Cerebral, intestinal and renal blood flow velocities, cardiac output parameters will be measured in premature neonates who will fulfill the eligibility criteria of the study.This study will be conducted at the neonatal intensive care units in Alexandria University Hospitals.

Official Title
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Effect of Anemia of Prematurity and Its Treatment on Hemodynamics of Preterm Infants

Conditions
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Premature

Intervention / Treatment
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* Radiation: Echocardiographic and Doppler studies


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Preterm infants ≤32 weeks gestational age, regardless their weight with postnatal age 3-6 weeks. Exclusion Criteria: -

Ages Eligible for Study
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Minimum Age: 3 Weeks
Maximum Age: 6 Weeks

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group I<br>(anemic group) | Radiation: Echocardiographic and Doppler studies<br>* Echographic and Doppler studies will be performed using machine: model GE Vivid iq premium,WUXI,China and we will measure: Cardiac output: Cerebral, intestinal and renal blood flow velocities:<br>|
| Group II<br>(non-anemic group) | Radiation: Echocardiographic and Doppler studies<br>* Echographic and Doppler studies will be performed using machine: model GE Vivid iq premium,WUXI,China and we will measure: Cardiac output: Cerebral, intestinal and renal blood flow velocities:<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 1. Cardiac output: | Probe: GE 12S-RS probe with a frequency range of 5 - 11 MHz. Cardiac output as the product of stroke volume and heart rate: actual body weight in mL/kg/min; Stroke volume (the product of velocity time integral at the level of aortic valve pulsed wave (PW) and cross-sectional area of the left ventricular outflow tract at the level of aortic valve using 2D.( | 3-6 weeks postnatal age | 
| 2. Cerebral blood flow velocities | in the anterior cerebral artery through the anterior fontanelle in the sagittal plane | 3-6 weeks postnatal age | 
| 3. Intestinal blood flow velocities | in the celiac artery from a longitudinal abdominal section, determined close to the origin of the artery from the abdominal aorta. | 3-6 weeks postnatal age | 
| 4.Renal blood flow velocities | Renal blood flow velocities in the right renal artery by placing the transducer below the right costal arch in the dorsolateral area of the flank in longitudinal axis. | 3-6 weeks postnatal age |