The Correlation Between Cotinine and Postoperative Acute and Chronic Pain After Hysterectomy

Study Overview
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Brief Summary
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It is known that there is an association between smoking and acute/chronic pain. But it is so difficult to assess this relation with asking questions to the patients in the preoperative period. Because of that we want to measure the levels of the cotinine in the urine and later assess the correlation with acute and chronic pain in hysterectomy patients.

Detailed Description
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It is well-known that smoking is very common in the public. The chronic pain after hysterectomy is 20-40%. The open abdominal hysterectomy ratio is 75% of all hysterectomy operations in our country. We know that the reasons of postoperative acute and chronic pain is multifactorial. One of them is smoking which affects the postoperative pain. The best way of measuring the level of cotinine is assesing the urine of the patient. We collect the first urine after induction. In this study, we aimed to investigate the correlation between the levels of urine cotinine and the acute and chronic postoperative pain in hysterectomy patents.

Official Title
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The Correlation Between the Cotinine Levels in Urine and Postoperative Acute and Chronic Pain in Open Abdominal Hysterectomy Patients

Conditions
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Chronic Pain, Acute Pain, Cotinine, Hysterectomy

Intervention / Treatment
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* Device: measuring cotinine level


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ASA I-II Open abdominal hysterectomy patients Exclusion Criteria: Chronic pain Chronic pain killer users Axis I psychiatric disease Liver disease Renal disease Drug allergy

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Screening
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: low (less 10ng/dl)<br>Patients who have low cotinine levels (less 10ng/dl) | Device: measuring cotinine level<br>* Measuring of the cotinine levels<br>|
| Other: medium (10-500ng/dl)<br>Patients who have medium cotinine levels (less 10-500ng/dl) | Device: measuring cotinine level<br>* Measuring of the cotinine levels<br>|
| Other: high (more 500ng/dl)<br>Patients who have high cotinine levels (less 10-500ng/dl) | Device: measuring cotinine level<br>* Measuring of the cotinine levels<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Chronic pain: VAS score | 3rd month pain after hysterectomy (VAS score) | Postoperative 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Acute pain: VAS score | Postoperative 24 hrs after hysterectomy (VAS score) | Postoperative 48 hours |