Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed By Surgery

Study Overview
=================
Brief Summary
-----------------
RATIONALE: Drugs used in chemotherapy, such as oxaliplatin, leucovorin, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. It is not yet known which combination chemotherapy regimen is more effective in treating colorectal cancer. PURPOSE: This randomized phase II/III trial is studying two combination chemotherapy regimens to compare how well they work in treating patients with metastatic colorectal cancer that cannot be removed by surgery.

Detailed Description
-----------------
OBJECTIVES: Primary Compare progression-free survival of patients with inoperable metastatic colorectal cancer treated with oxaliplatin, leucovorin calcium, and fluorouracil with vs without maintenance leucovorin calcium and fluorouracil. Demonstrate that time of disease control (TDC) can be increased by 15% at 9 months and that maintenance therapy can be avoided. Secondary Compare the overall survival and response rate in patients treated with these regimens. Compare the salvage surgery rate in patients treated with these regimens. Compare the tolerability of these regimens in these patients. Compare the quality of life in patients treated with these regimens. Compare the duration of chemotherapy-free intervals in patients treated with these regimens. Compare the pharmacoeconomy and pharmacogenetics of these regimens in these patients. OUTLINE: This is a randomized, controlled, open-label, multicenter study. Patients are stratified according to participating center, performance status (0-1 vs 2), number of metastatic sites (1 vs > 1), age (18-50 years vs 51-75 years vs 76-80 years), adjuvant chemotherapy, and baseline alkaline phosphatase (≤ 3 times upper limit of normal [ULN] vs > 3 times ULN). Patients are randomized to 1 of 2 treatment arms. Arm I FOLFOX chemotherapy: Patients receive oxaliplatin IV over 2 hours and leucovorin calcium IV over 2 hours on day 1 and fluorouracil IV continuously over 46 hours on days 1 and 2. Treatment repeats every 14 days for 6 courses in the absence of disease progression or unacceptable toxicity. Patients then proceed to maintenance chemotherapy. Maintenance chemotherapy: Patients receive leucovorin calcium IV over 2 hours on day 1 and fluorouracil IV continuously over 46 hours on days 1 and 2. Courses repeat every 14 days in the absence of disease progression or unacceptable toxicity. Patients with disease progression on maintenance chemotherapy receive 6 additional courses of FOLFOX as above. Patients with continued disease progression while receiving the additional courses of FOLFOX proceed to irinotecan-based chemotherapy off study. Arm II FOLFOX chemotherapy: Patients receive 6 courses of FOLFOX as in arm I. Patients with disease progression on FOLFOX receive 6 additional courses of FOLFOX. Patients with continued disease progression while receiving the additional courses of FOLFOX proceed to irinotecan-based chemotherapy off study. In both arms, patients with stable or responding disease may undergo surgical resection after completion of the initial 6 courses of FOLFOX. Quality of life is assessed at baseline, after courses 4 and 6, and then every 2-3 months thereafter. After completion of study treatment, patients are followed at 1 month and then every 3 months thereafter. PROJECTED ACCRUAL: A total of 600 patients will be accrued for this study.

Official Title
-----------------
Phase II-III Study of an Optimized LV-5FU-Oxaliplatin Strategy in Metastatic Colorectal Cancer. Optimox2 Study. C02-2

Conditions
-----------------
Colorectal Cancer

Intervention / Treatment
-----------------
* Drug: fluorouracil
* Drug: leucovorin calcium
* Drug: oxaliplatin


Participation Criteria
=================
Eligibility Criteria
-----------------
DISEASE CHARACTERISTICS: Histologically proven adenocarcinoma of the colon or rectum Metastatic disease No metastases involving only the bone Inoperable disease (i.e., not suitable for complete surgical resection) Measurable or evaluable disease Measurable disease defined as ≥ 1 unidimensionally measurable lesion ≥ 20 mm by conventional CT scan OR ≥ 10 mm by spiral CT scan No symptomatic ascites or pleural effusion that has not been evacuated No CNS metastasis PATIENT CHARACTERISTICS: WHO OR ECOG performance status 0-2 Absolute neutrophil count ≥ 1,500/mm^3 Platelets ≥ 100,000/mm^3 Creatinine < 3 times upper limit of normal (ULN) Alkaline phosphatase < 5 times ULN No peripheral neuropathy ≥ grade 1 No total or partial bowel obstruction Not pregnant or nursing Fertile patients must use effective contraception No uncontrolled hypercalcemia No other concurrent or prior malignancy, except adequately treated carcinoma in situ of the uterine cervix or basal or squamous cell carcinoma of the skin or cancer in complete remission for ≥ 5 years No uncontrolled congestive heart failure No angina pectoris No hypertension No arrhythmias No history of significant neurologic or psychiatric disorders No active infection No other serious nonmalignant disease PRIOR CONCURRENT THERAPY: No prior chemotherapy and/or immunotherapy for metastatic disease Prior adjuvant chemotherapy allowed provided progression-free interval after completion of adjuvant chemotherapy is > 6 months No other concurrent anticancer treatment No participation in another clinical trial with any investigational drug within 30 days prior to randomization No other concurrent investigational treatment No concurrent radiotherapy No concurrent cold cap for prevention of alopecia or iced mouth rinses for prevention of stomatitis

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: fluorouracil|nan|
|Drug: leucovorin calcium|nan|
|Drug: oxaliplatin|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overall survival |  |  | 
| Time to disease control |  |  | 
| Response as measured by RECIST criteria |  |  | 
| Toxicity |  |  | 
| Quality of life as assessed by EUROQOL- 5 Dimensional Instrument or Functional Assessment of Cancer Therapy-Neurotoxicity module version 4.0 at baseline and periodically during study treatment |  |  | 
| Pharmaco-economic evaluation |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
recurrent rectal cancer, stage IV rectal cancer, recurrent colon cancer, stage IV colon cancer, adenocarcinoma of the colon, adenocarcinoma of the rectum