Nutritional Supplementation in Cognitive Aging

Study Overview
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Brief Summary
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To evaluate the effect of supplemented berry fruit juice and whole fruit berry powder on memory performance and brain function in older adults

Detailed Description
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Randomized trials involving daily supplementation with berry fruits in older adults with early memory changes. The berry products include Concord grape juice, blueberry juice, and whole fruit blueberry powder. Supplementation periods are 12 and 16 weeks, depending on berry product. The Aims of the studies are to assess effects on cognitive performance and in a subset of participants, in brain activity.

Official Title
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Nutritional Supplementation in Cognitive Aging

Conditions
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Cognitive Aging

Intervention / Treatment
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* Dietary Supplement: Concord grape juice
* Dietary Supplement: placebo juice
* Dietary Supplement: blueberry juice
* Dietary Supplement: whole fruit blueberry powder
* Dietary Supplement: berry placebo powder


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Mild Cognitive Impairment Exclusion Criteria: Diabetes Weight of under 100 or over 210 pounds Chronic use of pain medication

Ages Eligible for Study
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Minimum Age: 66 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: grape juice active intervention<br>Concord grape juice administered daily for 12 or 16 weeks | Dietary Supplement: Concord grape juice<br>* Several ounces Concord grape juice administered 3 times a day for 12 or 16 weeks. Specific dosage determined by participant's weight.<br>* Other names: Welch's Concord Grape Juice;|
| Placebo Comparator: juice placebo<br>berry placebo juice administered daily for 12 or 16 weeks | Dietary Supplement: placebo juice<br>* several ounces placebo juice consumed three times a day for 12 or 16 weeks; dosage determined according to participant's weight<br>|
| Active Comparator: blueberry juice active intervention<br>wild blueberry juice administered daily for 12 weeks | Dietary Supplement: blueberry juice<br>* wild blueberry juice administered daily for 12 weeks, dosage determined according to participant's weight<br>|
| Active Comparator: blueberry powder intervention<br>whole fruit blueberry powder administered daily for 16 weeks | Dietary Supplement: whole fruit blueberry powder<br>* whole fruit, freeze dried blueberry powder derived from a blend of cultivated blueberries administered daily for 16 weeks<br>|
| Placebo Comparator: powder placebo<br>placebo powder administered daily for 16 weeks | Dietary Supplement: berry placebo powder<br>* berry placebo powder administered daily for 16 weeks<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| memory performance |  | at the end of the intervention | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| cortisol |  | at the end of the intervention | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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memory, aging