Time Prediction and Cerebellum: Magnetic Transcranial Stimulation (TMS) in Healthy Volunteers

Study Overview
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Brief Summary
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The aim of the study is to check the role of the cerebellum in time prediction in healthy volunteers, by means of magnetic transcranial stimulation targeted on the cerebellum, and recording of behavioural measures indexing time prediction

Official Title
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Effects of the Magnetic Transcranial Stimulation (TMS) in Healthy Volunteers

Conditions
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Schizophrenia

Intervention / Treatment
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* Device: TMS targeted on the cerebellum


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Participant, male or female, between 18 and 60 years old Subject affiliated to a social health insurance scheme (beneficiary or entitled person) Subject who has dated and signed an informed consent form For a woman of childbearing age, negative pregnancy test and effective contraception throughout the study Exclusion Criteria: - Participant with substance use disorders (as defined by DSM-V) Participants taking benzodiazepines and related substances (in the period before inclusion, for a duration equivalent to 5 half-lives of the product), cannabis (in the 2 months before inclusion) or hallucinogenic substances (in the period before inclusion, for a duration equivalent to 5 half-lives of the product). Participant with neurological pathology or sequelae Participant with Attention Deficit Hyperactivity Disorder (ADHD) Participant with a borderline personality disorder Participant with disabling sensory impairments, including visual acuity (corrected, if applicable) < 0.8 (due to use of visual material) (Freiburg Vision Test, Bach 1996) Participant deprived of liberty or subject to the safeguard of justice Participant under guardianship or curatorship Participant in a period of exclusion defined by another clinical study or participant in a study that may impact on research results Pregnant or breastfeeding woman Subject with a contraindication to performing an MRI or TMS: presence of non-removable ferromagnetic body, prosthesis, pacemaker, medication delivered by an implanted pump, vascular clip or stent, heart valve or ventricular lead, certain intracerebral clips, cochlear implants, history of epilepsy, skin pathology at the point of contact with the electrodes. Subject with a history of major neurological or psychiatric illness with current psychotropic medication (i.e., antidepressant, thyroid regulator, antipsychotic, benzodiazepine and related drugs, or hypnotic).

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| TMS on the cerebellum followed by placebo TMS<br>TMS preceding the time prediction and language tests | Device: TMS targeted on the cerebellum<br>* Impact on EEG performance (preparation wave in temporal tasks) of cerebellar stimulation by MSD in healthy subjects. The contrast between the post-stimulation effects of verrum stimulation and placebo stimulation will indicate the magnitude of the effect and will allow us to optimize the type of protocol that may be useful in schizophrenia.<br>|
| Placebo TMS followed by TMS on the cerebellum<br>TMS preceding the time prediction and language tests | Device: TMS targeted on the cerebellum<br>* Impact on EEG performance (preparation wave in temporal tasks) of cerebellar stimulation by MSD in healthy subjects. The contrast between the post-stimulation effects of verrum stimulation and placebo stimulation will indicate the magnitude of the effect and will allow us to optimize the type of protocol that may be useful in schizophrenia.<br>|
| TMS on the cerebellum set in time on waiting periods<br> | Device: TMS targeted on the cerebellum<br>* Impact on EEG performance (preparation wave in temporal tasks) of cerebellar stimulation by MSD in healthy subjects. The contrast between the post-stimulation effects of verrum stimulation and placebo stimulation will indicate the magnitude of the effect and will allow us to optimize the type of protocol that may be useful in schizophrenia.<br>|
| TMS on the cerebellum not set in time on waiting periods<br> | Device: TMS targeted on the cerebellum<br>* Impact on EEG performance (preparation wave in temporal tasks) of cerebellar stimulation by MSD in healthy subjects. The contrast between the post-stimulation effects of verrum stimulation and placebo stimulation will indicate the magnitude of the effect and will allow us to optimize the type of protocol that may be useful in schizophrenia.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| EEG index of time expectation | CNV | 40 minutes | 
| EEG index of time expectation | beta oscillation | 40 minutes |