Impact of the Severity of Pediatric Psoriasis on Childhood Body Mass Index

Study Overview
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Brief Summary
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The object of this research study is to examine these associations in children as very little is known about psoriasis and cardiovascular risk factors in the pediatric population.

Detailed Description
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Several environmental factors and comorbid conditions have been found to be associated with psoriasis in adults, including obesity, depression, smoking, and other cardiovascular risk factors such as high blood pressure. The object of this research study is to examine these associations in children as very little is known about psoriasis and cardiovascular risk factors in the pediatric population. This is a multi-center study with a planned total enrollment of about 200 subjects ages 2-17 years old with psoriasis and 100 aged-match controls. Patient and family history will be recorded. All subjects will undergo standard height, weight, blood pressure, and waist circumference (WC). For the obese and overweight subjects we will also obtain their growth charts to attempt to correlate weight gain with psoriasis onset and progression. All data will be compiled and then statistically analyzed.

Official Title
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Impact of the Severity of Pediatric Psoriasis on Childhood Body Mass Index and Comorbid Risk Factors: an Epidemiologic Analysis

Conditions
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Psoriasis, Atopic Dermatitis

Intervention / Treatment
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* Other: Blood pressure
* Other: Height
* Other: Weight
* Other: BMI
* Other: Waist Circumference


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Subjects must be between the ages of 5 and 17 years at the time of enrollment. Subjects of either sex. Subjects who have had psoriatic plaques for more than 6 months. Subjects and guardians of minors must sign the approved IRB consent form(s) prior to initiation of the study protocol. Subjects enrolled as non-inflammatory normal controls will carry a common non- systemic skin condition, such as acne, nevi, warts and molluscum as their main diagnosis. Subjects enrolled as inflammatory normal controls will carry a diagnosis of moderate to severe atopic dermatitis. Exclusion Criteria: Subjects who are unable to give informed consent or assent. Subjects who have had psoriasis for less than 6 months. Subjects whose condition is deemed unsafe or incapable by the study investigator for study participation.

Ages Eligible for Study
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Minimum Age: 5 Years
Maximum Age: 17 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Psoriasis<br>Children ages 5-17 years old with moderate or severe plaque type psoriasis. Blood pressure will be measured once while patient is seated Height will be measured in centimeters at the time of enrollment Weight will be measured in kilograms at enrollment Body Mass Index (BMI) will be calculated from a subject's height and weight Waist circumference will be measured midway between the lowest rib and the superior border of the iliac crest with an inelastic measuring tape at the end of normal expiration to the nearest 0.1cm | Other: Blood pressure<br>* Blood pressure will be measured once while patient is seated<br>Other: Height<br>* Height will be measured in centimeters at the time of enrollment<br>Other: Weight<br>* Weight will be measured in kilograms at enrollment<br>Other: BMI<br>* Body Mass Index (BMI) will be calculated from a subject's height and weight<br>Other: Waist Circumference<br>* Waist circumference will be measured midway between the lowest rib and the superior border of the iliac crest with an inelastic measuring tape at the end of normal expiration to the nearest 0.1cm<br>|
| Atopic Dermatitis Controls<br>Children ages 5 to 17 years old with moderate to severe atopic dermatitis. Blood pressure will be measured once while patient is seated Height will be measured in centimeters at the time of enrollment Weight will be measured in kilograms at enrollment Body Mass Index (BMI) will be calculated from a subject's height and weight Waist circumference will be measured midway between the lowest rib and the superior border of the iliac crest with an inelastic measuring tape at the end of normal expiration to the nearest 0.1cm | Other: Blood pressure<br>* Blood pressure will be measured once while patient is seated<br>Other: Height<br>* Height will be measured in centimeters at the time of enrollment<br>Other: Weight<br>* Weight will be measured in kilograms at enrollment<br>Other: BMI<br>* Body Mass Index (BMI) will be calculated from a subject's height and weight<br>Other: Waist Circumference<br>* Waist circumference will be measured midway between the lowest rib and the superior border of the iliac crest with an inelastic measuring tape at the end of normal expiration to the nearest 0.1cm<br>|
| Healthy Controls<br>Children 5-17 years of age who are healthy and seen in dermatology clinic for a non-systemic skin condition. Blood pressure will be measured once while patient is seated Height will be measured in centimeters at the time of enrollment Weight will be measured in kilograms at enrollment Body Mass Index (BMI) will be calculated from a subject's height and weight Waist circumference will be measured midway between the lowest rib and the superior border of the iliac crest with an inelastic measuring tape at the end of normal expiration to the nearest 0.1cm | Other: Blood pressure<br>* Blood pressure will be measured once while patient is seated<br>Other: Height<br>* Height will be measured in centimeters at the time of enrollment<br>Other: Weight<br>* Weight will be measured in kilograms at enrollment<br>Other: BMI<br>* Body Mass Index (BMI) will be calculated from a subject's height and weight<br>Other: Waist Circumference<br>* Waist circumference will be measured midway between the lowest rib and the superior border of the iliac crest with an inelastic measuring tape at the end of normal expiration to the nearest 0.1cm<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| BMI |  | 07/2010 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood Pressure |  | 07/2010 | 
| Waist circumference |  | 07/2010 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Psoriasis, Obesity, BMI, Atopic Dermatitis