High Versus Low Frequency rTMS on Motor Dysfunction in PD

Study Overview
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Brief Summary
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The aim of the study is to compare high versus low frequency rTMS on motor dysfunction in PD. Forty patients with PD participated in the study. The patients were randomly assigned into two groups; the first group received 1Hz and the 2nd one received 20 Hz rTMS daily for 10 days 5 sessions every week. The doctors who assess the patients clinically is blind for the frequency of rTMS, also patients don't know which type of stimulation they received. The patients were followed up before and after the 10 sessions and one month later.

Detailed Description
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The aim of the study is to compare high versus low frequency rTMS on motor dysfunction in PD. Forty patients with PD participated in the study. The patients were randomly assigned into two groups; the first group received 1Hz and the 2nd one received 20 Hz rTMS daily for 10 days 5 sessions every week and 2 days off per week. The doctors who assess the patients clinically is blind for the frequency of rTMS, also patients don't know which type of stimulation they received. The patients were followed up before and after the 10 sessions and one month later.

Official Title
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The Effect of High Versus Low Frequency Repetitive Transcranial Magnetic Stimulation on Motor Dysfunction in Parkinson's Disease; Which is More Beneficial?

Conditions
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Parkinson Disease

Intervention / Treatment
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* Device: rTMS


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All PD patients who were diagnosed according to UK bank criteria for PD. Exclusion Criteria: History of repeated head injury. History of repeated cerebrovascular strokes History of defined encephalitis Oculogyric crisis, supra nuclear gaze palsy. Family history of more than one relative severe dementia, MMSE < 23, severe depression Cerebellar signs Babiniski sign Hydrocephalus or intracranial lesion on neuroimaging Patients with intracranial on neuroimaging Patients with intracranial metallic device or pacemaker Patients who were unable to give informed consent because of severe anesthesia, or cognitive deficit

Ages Eligible for Study
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Minimum Age: 50 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: High Frequency rTMS in PD<br>The first group received 20 Hz rTMS on M1 daily for 10 days 5 sessions every week. | Device: rTMS<br>* the first group received 20 Hz and the 2nd group received 1 Hz rTMS daily for 10 days 5 sessions every week on M1.<br>|
| Active Comparator: Low Frequency rTMS in PD<br>The second group received 1 Hz rTMS on M1 daily for 10 days 5 sessions every week. | Device: rTMS<br>* the first group received 20 Hz and the 2nd group received 1 Hz rTMS daily for 10 days 5 sessions every week on M1.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change in motor disability | Measure the change in motor disability by using UPDRS and self assessment scale | one month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in Cortical excitability | Measure the changes in cortical excitability using magnetic stimulation appratus | Two weeks |