Pharmacokinetics and Pharmacodynamics of Fructose

Study Overview
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Brief Summary
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The purpose of this study is to determine whether sucrose vs high fructose corn syrup from a soft drink results in differences in various metabolic byproducts such as fructose, glucose, serum uric acid, triglyceride and lactate.

Detailed Description
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Fructose consumption has risen sharply during the past several decades. Since its introduction to the United States in 1967, high fructose corn syrup (HFCS) has overtaken sucrose as the main sweetener in manufactured foods and beverages, and thus, is responsible for the approximately 30% increase in fructose in our diet. Numerous studies have shown that excessive fructose consumption can cause a variety of harmful metabolic effects, suggesting that fructose may partially be responsible for the current epidemic in obesity, hypertension, metabolic syndrome, and diabetes. This preliminary study will investigate the pharmacokinetics and pharmacodynamics of fructose in a broad population. Specifically, the goal of our research are to compare the impact of the two main sources of dietary fructose, sucrose versus HFCS, on fructose bioavailability and acute metabolic changes by measuring response phenotypes, such as serum uric acid, lactate, and triglyceride levels.

Official Title
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Pharmacokinetics and Pharmacodynamics of Fructose Following Soft Drink Consumption: Sucrose vs High Fructose Corn Syrup

Conditions
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Healthy

Intervention / Treatment
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* Other: Dr Pepper sweetened with sucrose or high fructose corn syrup


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: adult subjects aged 18 years or older either gender any ethnicity willing to abstain from drinking any alcohol 3 days prior to a study visit Exclusion Criteria: history of liver or kidney disease history of diabetes mellitus or fasting blood glucose ≥ 126 mg/dl or random blood glucose ≥ 200 mg/dl currently taking any medication (except oral contraceptives) consume more than 1 alcoholic drink per day pregnant or breast-feeding blood donor in the previous 8 weeks history of gout

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Public<br>General public. Those who are not currently taking any medication besides birth control pills. | Other: Dr Pepper sweetened with sucrose or high fructose corn syrup<br>* Comparison of different formulations of fructose.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fructose |  | baseline, 15min, 30 min, 60 min, 90 min, 2 hr, 3 hr, 4.5 hr, 6 hr | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| serum uric acid |  | baseline, 15 min, 30 min, 60 min, 90 min, 2 hr, 3 hr, 4.5 hr, 6 hr | 
| glucose |  | baseline, 15 min, 30 min, 60 min, 90 min, 2 hr, 3 hr, 4.5 hr, 6 hr | 
| lactate |  | baseline, 15 min, 30 min, 60 min, 90 min, 2 hr, 3 hr, 4.5 hr, 6 hr | 
| triglycerides |  | baseline, 15 min, 30 min, 60 min, 90 min, 2 hr, 3 hr, 4.5 hr, 6 hr | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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fructose, sucrose, high fructose corn syrup, serum uric acid, lactate, glucose, triglycerides, Bioavailability of fructose from two formulations