linjc16/ctgov huggingface dataset:
A Trial to Investigate Hyperglycemic and Hypoglycemic Excursions in Subjects With Type 1 Diabetes

Study Overview
=================
Brief Summary
-----------------
This is a single center, double-blind, randomized trial in subjects with type 1 diabetes mellitus applying an adaptive design approach.

Detailed Description
-----------------
Subjects were be studied on two occasions, in randomized sequence, whereby glycemic excursions are assessed following an oral mixed meal challenge while treated with either insulin alone or co-administered insulin and glucagon.

Official Title
-----------------
A Randomized, Double-blinded Trial to Investigate Glycemic Excursions Following an Oral Mixed Meal Challenge in Subjects With Type 1 Diabetes When Concomitantly Treated With Insulin Alone or Co-administered Insulin and Glucagon

Conditions
-----------------
Type 1 Diabetes Mellitus With Hypoglycemia

Intervention / Treatment
-----------------
* Drug: Glucagon
* Drug: Insulin


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Male or female patients aged between 18 and 64 years (both inclusive) Type 1 diabetes mellitus (as diagnosed clinically) ≥ 12 months prior to the screening visit Treated with daily insulin for T1DM ≥ 12 months prior to the screening visit Exclusion Criteria: -

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 64 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Insulin IV<br>calculated insulin rate | Drug: Insulin<br>* calculated IV Insulin dose infused at a constant rate<br>* Other names: Human Insulin (Eli Lilly);|
| Experimental: Insulin and Glucagon IV<br>calculated molar ratio insulin:glucagon | Drug: Glucagon<br>* calculated IV insulin:Glucagon molar ratio<br>* Other names: Glucagen Hypokit;Drug: Insulin<br>* calculated IV Insulin dose infused at a constant rate<br>* Other names: Human Insulin (Eli Lilly);|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| hypoglycemic excursions | < 50mg/dl | 180-360 minutes post meal | 
| hyperglycemic excursions | >150mg/dl | 60-120 minutes post meal |
Statin With Palliative Therapy for HCC

Study Overview
=================
Brief Summary
-----------------
Statin is a preventive medicine for hepatitis B and hepatitis C which decreases the risk turning into liver cancer,however, the investigators also discovered that patients taking Statin live longer than patients who didn't take Statin in the incidence of liver cancer death cases.

Detailed Description
-----------------
Most liver cancer patients did not accept the cure as the main objective of the treatment after diagnosis because they choose alternative therapies palliative based, such as hepatic arterial chemoembolization, chemotherapy and radiation therapy. Statin is a preventive medicine for hepatitis B and hepatitis C which decreases the risk turning into liver cancer, yet the clinical effect for Statin is still unknown. In a previous study of 20,220 liver cancer patients in health care database, the investigators discovered that patients taking Statin live longer than patients who didn't take Statin in the incidence of liver cancer death cases. This study is a continuation of previous health insurance database studies for clinical trials to verify whether Statin could prolong disease-free survival role for palliative treatment of liver cancer.

Official Title
-----------------
Statin With Palliative Therapy for HCC

Conditions
-----------------
HCC

Intervention / Treatment
-----------------
* Drug: Statin


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: >20 years old. BCLC stage B , stage C and stage D Exclusion Criteria: Cancer diagnosis before HCC was conﬁrmed and incurable. <20 years old, > 90years old. Patients who are judged to be ineligible for study entry by the investigator or subinvestigator

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Statin(Crestor) taken<br>Subjects take Statin(Crestor) 10mg per day for a- year | Drug: Statin<br>* Divide HCC patients into two groups under randomization, one is with Statin and the other is without Statin to verify whether Statin could prolong disease-free survival<br>|
| No Intervention: non Statin(Crestor) taken<br>non Statin(Crestor) taken as a reference for experimental group. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overall Survival |  | Up to two year |
Fibromyalgia and Psychiatric Symptoms Among PMS and PMDD Patients

Study Overview
=================
Brief Summary
-----------------
Assessing FM and psychiatric disorder in patients suffering from PMS or PMDD

Conditions
-----------------
Premenstrual Syndrome

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: PMDD PMS Referral to gynecologist clinic without symptoms of PMS or PMDD

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
A Survey Exploring Health and Screening Tests in People Treated for Hodgkin Lymphoma

Study Overview
=================
Brief Summary
-----------------
A survey of health beliefs and cancer screening behaviour and intentions in Hodgkin lymphoma survivors

Detailed Description
-----------------
A survey of Hodgkin lymphoma survivors registered in a follow-up database, examining health beliefs (using Health Belief Model) around breast, bowel and lung cancer screening, previous screening uptake and future uptake intentions

Official Title
-----------------
A Study of Health Beliefs and Cancer Screening Behaviours and Intentions in Hodgkin Lymphoma Survivors

Conditions
-----------------
Hodgkin Lymphoma

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Details held in the ADAPT database at The Christie NHS Foundation trust Aged 18-80 Previously treated for Hodgkin lymphoma without evidence of relapse for at least 5 years Treated with radiotherapy and/or alkylating agent containing chemotherapy Exclusion Criteria: * Have previously stated they do not wish to be contacted for research

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The psychosocial factors predictive of uptake of breast, bowel and lung cancer screening in HL survivors | Questionnaires | At baseline visit |
Recovery Management Intervention in China

Study Overview
=================
Brief Summary
-----------------
The purpose of the study is to develop and pilot-test a Recovery Management Intervention (RMI) program for heroin addicts released from compulsory rehabilitation in China. The project has the following specific aims: Primary aims: Aim 1. To engage key stakeholders in the local communities involved in supporting the transition of heroin addicts released from compulsory rehabilitation to the community; Aim 2. To identify potential barriers for participating in MMT in China; Aim 3. To develop and deliver educational/training materials on HIV risks, relapse prevention, and MMT; Aim 4. To adapt and develop the Recovery Management Intervention (RMI) program for heroin addicts released from compulsory rehabilitation in China; Aim 5. To conduct a pilot trial and obtain preliminary outcome data associated with RMI, relative to enhanced standard care. Secondary aim: Aim 6. To explore predictors of relapse and HIV/AIDS risk behaviors. It is hypothesized that the intervention will reduce drug use relapse and the negative consequences associated with relapse, including HIV risk behaviors

Official Title
-----------------
Reducing HIV/AIDS and Drug Abuse Among Heroin Addicts Released From Compulsory Rehabilitation in China

Conditions
-----------------
Methadone, HIV Infections

Intervention / Treatment
-----------------
* Behavioral: Recovery management


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria:The study population will be drawn from all adult patients at participating compulsory rehabilitation facilities who: have been incarcerated for at least one year and would have been eligible for MMT at the time of incarceration, have at least 1 month remaining before release, met the DSM-IV criteria for heroin dependence at the time of incarceration, are willing to enroll in methadone maintenance treatment, and are Shanghai residents who reside in the areas of Shanghai targeted by the study. Exclusion Criteria: Individuals diagnosed with severe mental illness will not be eligible to participate.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Recovery management intervention<br> | Behavioral: Recovery management<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Comparison of McGrath and Macintosh Laryngoscopes for Insertion of a Double Lumen Tube by Residents

Study Overview
=================
Brief Summary
-----------------
The insertion of double lumen tube is difficult even more if it is a resident with no experience. we think that using videolaryngoscopes for novice ones would facilitate insertion of double lumen tube thanks to the visualization on a LCD screen of the laryngeal structure.

Official Title
-----------------
Comparison of McGrath and Macintosh Laryngoscopes for Insertion of a Double Lumen Tube by Residents

Conditions
-----------------
Thoracic Injuries

Intervention / Treatment
-----------------
* Device: macGrath
* Device: Macintosh's


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Thoracic Surgery Insertion of double lumen tube Exclusion Criteria: Emergency surgery Risk of inhalation Person unable to consent Persons deprived of liberty, under guardianship or trusteeship Pregnant or lactating woman Allergy to Tracrium, Propofol, Sufentanil

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Mac grath group<br> | Device: macGrath<br>* in the mac grath group we use the videolaryngoscope macGrath as first-line for the insertion of double lumen tube<br>|
| Active Comparator: Macintosh Group<br> | Device: Macintosh's<br>* in the macintosh group we use the laryngoscope with Macintosh's blade as first-line for the insertion of double lumen tube<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of success of intubation in both groups at the first attempt | the success is defined as a correct implementation of the probe endotracheal in double light by an internal of anesthesia in the 1st attempt. | Baseline: one session | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Individual Determination of Cormack Stage | scoring system for the grading of direct laryngoscopy in case of tracheal intubation is difficult | Baseline: one session | 
| Rate of good positioning of double lumen tube confirmed by fibroscopy |  | Baseline: one session | 
| The rate of patients with an increase in systolic blood pressure of more than 20% compared to the measurement before insertion of the probe |  | Baseline: one session | 
| Intubation time |  | Baseline: one session | 
| The rate of patients with pharyngeal pains upon awakening |  | Baseline: one session | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Mac Grath, Double lumen tube
Early Administration of Lactose-free Milk in Children Presenting With Acute Diarrhea

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine which nutritional regime is better for acute diarrhea in outcomes.

Detailed Description
-----------------
Diarrhea is still the most important cause of mortality and morbidity in children of the developing countries. We evaluated the effectiveness of early administration of lactose free milk in the management of acute diarrhea in children below two years old.

Official Title
-----------------
Study of Nutritional Regime for Acute Diarrhea

Conditions
-----------------
Acute Diarrhea

Intervention / Treatment
-----------------
* Dietary Supplement: lactose-free milk
* Dietary Supplement: conventional milk


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: children with acute non-bloody diarrhea (≤ 2 weeks) mild to moderate dehydration Exclusion Criteria: mucous bloody stools major systemic illness severe malnutrition (Weight for age <60% and Weight for height <70 %) history of antibiotics receiving

Ages Eligible for Study
-----------------
Minimum Age: 3 Months
Maximum Age: 14 Months

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: lactose-free milk<br>it is kind of nutritional regime | Dietary Supplement: lactose-free milk<br>* a milk without lactose<br>* Other names: nothing;|
| Other: conventional milk<br>it is kind of nutritional regime | Dietary Supplement: conventional milk<br>* a milk with lactose<br>* Other names: nothing;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| duration of diarrhea | Duration of diarrhea corresponded to the time from enrollment to the cessation of diarrhea, which was defined as the passage of the last watery or loose stool before passage of two consecutive formed stools or no stool in a 24-hour period. | at seven days after admission | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| changes in weight gaining | nude weight was measured with scale with an accuracy of 10 g at admission time and seven days after admission | at seven days after admission | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
diarrhea, lactose, milk, weight, acute.
Reshaping Exercise Habits and Beliefs (REHAB)

Study Overview
=================
Brief Summary
-----------------
Regular exercise has been demonstrated to improve muscle strength, balance, coordination as well as improve cardiovascular fitness levels and overall quality of life in stroke survivors. This study is designed to test the feasibility and effectiveness of a 12-week intervention to education and encourage stroke survivors to exercise following discharge from rehabilitation settings using a walking program and targeted functional activity homework.

Official Title
-----------------
Reshaping Exercise Habits and Beliefs (REHAB): Pilot Testing of a Behavioral Intervention to Improve Mobility After Stroke

Conditions
-----------------
Cerebrovascular Accident, Stroke

Intervention / Treatment
-----------------
* Behavioral: Exercise
* Other: Stroke education


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 40-85 years old ischemic Stroke patients, Stroke onset <90 days at enrollment, Hemiparetic gait disorder, Patients able to walk 30ft with or w/out assistive device, Sufficient English comprehension to understand instructions, provide consent, and answer questions, Lives within 30 miles of the Greater Baltimore area. Exclusion Criteria: Dementia (extended MMSE <85 or <80 if education level below 9th grade), Untreated major clinical depression (CES-D>16) and confirmed with clinical interview, Heavy alcohol use (<3 oz liquor, 3, 4-oz glasses of wine, or 3, 12- oz beers daily), Active cancer, or any illness with a life expectancy of less than 6 months, Any condition in which exercise activity would be contraindicated including, but not limited to: unstable angina, cardiac ischemic event within the past 6 months, congestive heart failure (Stage III or IV), major orthopedic chronic pain or non-stroke neuromuscular disorders restricting exercise, oxygen-dependent COPD or peripheral neuropathy.

Ages Eligible for Study
-----------------
Minimum Age: 40 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Arm 1<br>Home-based exercise prescriptions with weekly motivational telephone calls. | Behavioral: Exercise<br>* Home-based exercise prescriptions with weekly motivational telephone calls.<br>|
| Other: Arm 2<br>Stroke education program with matched attention phone calls | Other: Stroke education<br>* Stroke education program with matched attention phone calls<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ambulatory Activity Profile |  | 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Exercise, Rehabilitation, Stroke
The Ability of Perfusion Index and Positional Perfusion Index Variation to Predict Spinal Anesthesia-induced Hypotension in Elderly Patients

Study Overview
=================
Brief Summary
-----------------
In this study, we will test the ability of positional perfusion index variation to predict post-spinal anesthesia hypotension in elderly patients.

Official Title
-----------------
The Ability of Perfusion Index and Positional Perfusion Index Variation to Predict Spinal Anesthesia-induced Hypotension in Elderly Patients: A Prospective Observational Study

Conditions
-----------------
Spinal Anesthesia Induced Hypotension

Intervention / Treatment
-----------------
* Device: positional perfusion index variation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 65 years of age or more. ASA score I & II. Patients scheduled for surgeries under spinal anesthesia. Exclusion Criteria: Negative consent. pre-existing hypertension Diabetes mellitus or autonomic neuropathy. Emergency operations. Absolute contraindications or failure to perform spinal anesthesia.

Ages Eligible for Study
-----------------
Minimum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: positional perfusion index variation|positional perfusion index variation to predict spinal anesthesia-induced hypotension in elderly patients|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The sensitivity of perfusion index postural change in predicting spinal anesthesia-induced hypotension in elderly patients. | The sensitivity of incremental change of a measured perfusion index pre and post spinal anesthesia | 30 minutes after spinal anesthesia | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| incidence of spinal anesthesia induced hypotension in elderly | incidence of spinal anesthesia induced hypotension in elderly | 30 minutes after spinal anesthesia | 
| • The sensitivity of supine perfusion index to predict spinal anesthesia-induced hypotension in elderly patients. | • The sensitivity of supine perfusion index to predict spinal anesthesia-induced hypotension in elderly patients. | 30 minutes after spinal anesthesia | 
| • The sensitivity of sitting perfusion index to predict spinal anesthesia-induced hypotension in elderly patients. | • The sensitivity of sitting perfusion index to predict spinal anesthesia-induced hypotension in elderly patients. | 30 minutes after spinal anesthesia |
MobileMedMinder: A Networked Aide for Medication Compliances

Study Overview
=================
Brief Summary
-----------------
The main aim of this study is to conduct a randomized control trial to compare MobileMedMinder, a mobile phone based medication reminder software product, with currently accepted and empirically supported methods for increasing medication compliance through reminders and tracking.

Official Title
-----------------
MobileMedMinder: A Networked Aide for Medication Compliances

Conditions
-----------------
Heart Failure, Congestive

Intervention / Treatment
-----------------
* Behavioral: Use of MobileMedMinder


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Taking beta blockers, ACE or ARB, and hydralazine for treatment of HF. Exclusion Criteria: Inability to understand informed consent Inability to read and understand English

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Use of MobileMedMinder<br> | Behavioral: Use of MobileMedMinder<br>* Use of an intervention to remind patients to take their medications.<br>|
| No Intervention: Usual care<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Compliance | Pill counts will be used to assess compliance | 3 months |