Optic Nerve Sheath After Extracorporeal Circulation

Study Overview
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Brief Summary
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The purpose of this study is to assess the influence of extracorporeal circulation during cardiac surgery on the optic nerve sheath diameter (ONSD) after the surgery.

Detailed Description
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ONSD will be measured before and 1 hour after the surgery and in the morning of day 1 after the surgery. Fluid balance and lactate will be measured too. PONV will be assessed. Patients will be evaluated with MoCA test on the day before surgery and on the day 3 after the surgery for cognitive disfunction.

Official Title
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The Influence of Extracorporeal Circulation During Cardiac Surgery on Optic Nerve Sheath Diameter

Conditions
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Cardiac Disease, Cardiac Valve Disease

Intervention / Treatment
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* Diagnostic Test: ultrasound measurement of the optic nerve sheath diameter
* Diagnostic Test: MoCA test


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: heart surgery with use of cardiopulmonary bypass Exclusion Criteria: pregnancy and lactation neurologic disorders hyperthyroidism optic nerve disorders

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| standard cardiopulmonary bypass<br>patients 18 year or older undergoing heart surgery with standard cardiopulmonary bypass | Diagnostic Test: ultrasound measurement of the optic nerve sheath diameter<br>* ultrasound measurement of the optic nerve sheath diameter<br>Diagnostic Test: MoCA test<br>* MoCA test is a short bedside test for measuring cognitive disfunction<br>|
| mini-cardiopulmonary bypass<br>patients 18 year or older undergoing heart surgery with standard mini-cardiopulmonary bypass | Diagnostic Test: ultrasound measurement of the optic nerve sheath diameter<br>* ultrasound measurement of the optic nerve sheath diameter<br>Diagnostic Test: MoCA test<br>* MoCA test is a short bedside test for measuring cognitive disfunction<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ultrasound measuring of optic nerve sheath diameter baseline | Baseline optic nerve sheath diameter measurement before start of surgery with a linear ultrasound probe (Scan) in coronal and axial plane | Before start of surgery | 
| Ultrasound measuring of optic nerve sheath diameter end of surgery | Optic nerve sheath diameter measurement 1 hour after the end of surgery with a linear ultrasound probe in coronal and axial plane | 1 hour after the end of surgery | 
| Ultrasound measuring of optic nerve sheath diameter day 1 | Optic nerve sheath diameter measurement in the morning on day 1 after the surgery with a linear ultrasound probe in coronal and axial plane | day 1 after the surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| postoperative cognitive disfunction measured with the MoCA test | MoCA test is a validated test for cognitive disfunction, especially in patients who are elderly than 60 years, the study is comparing the MoCA test values on the day before surgery with the values on day 3 after the surgery | on the day before surgery, on day 3 after the surgery | 
| postoperative nausea and vomiting (PONV) | Postoperative nausea and vomiting is common after cardiac surgery, the occurrence of postoperative nausea and vomiting will be recorded | during the first 24 hours after surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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extracorporeal circulation, otpic nerve sheath diameter, postoperative cognitive disfunction, postoperative nausea and vomiting