Resting Postural Tremor in Multiple Sclerosis

Study Overview
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Brief Summary
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Early diagnosis is a key factor for effective treatment of multiple sclerosis. Accelerometer and gyroscope measurement of tremor could screen potential motor control dysfunction and predict a risk for development of multiple sclerosis.

Detailed Description
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The aim of this study is to test whether specially developed accelerometer and gyroscope can differentiate pattern of resting postural tremor in healthy and people with multiple sclerosis. Spectral analysis and the correlation of the average signal spectra will be computed. Moreover, categorization based on the tremor component according to the maximum likelihood estimation will be done.

Official Title
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Spectral Analyses of Resting Postural Tremor Measured by Accelerometer and Gyroscope as a Predictive Tool of Multiple Sclerosis

Conditions
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Multiple Sclerosis

Intervention / Treatment
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* Behavioral: Examination of tremor and upper hand functions


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Group 1: Definite diagnosis of MS prevailed motor deficit of upper extremities, but without visible tremor stable clinical status in the preceding 3 months Expanded Disability Status Scale score (EDSS) ≥ 2 ≤ 7.5, and no corticosteroid therapy in the preceding month Group 2: Healthy volunteers in the age of 20-70 years will be employed There will be defined as persons without any neurological disease diagnose at the time of the measurement. Exclusion Criteria (both groups): Patients with factors disturbing mobility (e.g. stroke, pregnancy, fractures) were excluded from the study.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with multiple sclerosis<br>MS patients will be chosen by an independent neurologist. | Behavioral: Examination of tremor and upper hand functions<br>* Participants will be only examined. They will not undergo any intervention.<br>|
| Healthy volunteers<br>Healthy controls will be paired by age and sex with MS patients. | Behavioral: Examination of tremor and upper hand functions<br>* Participants will be only examined. They will not undergo any intervention.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Tremor | accelerometer (1 m·s-2) | baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hand grip strength | Hand dynamometer JAMA | baseline | 
| Hand and arm function | Nine Hole Peg Test | baseline | 
| Psychomotor processing speed | Coin Rotation Task | baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Tremor, Accelerometer