The Effect of Loading Dose of Magnesium Sulfate on Uterine, Umbilical, and Fetal Middle Cerebral Arteries Doppler, Biophysical Profile, CTG, Maternal Vital Signs in Women With Severe Preeclampsia

Study Overview
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Brief Summary
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100 women with severe preeclanpsia received Magnesium sulfate 6 grams intravenous over 20 minutes as a loading dose. Resistance index [RI], pulsatility index [PI] and systolic/diastolic [S/D] ratio of the umbilical artery, uterine aryery and fetal middle cerebral artery before and repeated 20 minutes after intravenous administration of 6 grams of magnesium sulphate (loading dose) over 20 minutes . fetal breathing movements and fetal gross movements are counted within 20 minutes, before and after intravenous administration of 6 grams of magnesium sulphate (loading dose) over 20 minutes

Detailed Description
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100 women with severe preeclanpsia received Magnesium sulfate 6 grams intravenous over 20 minutes as a loading dose. Resistance index [RI], pulsatility index [PI] and systolic/diastolic [S/D] ratio of the umbilical artery, uterine aryery and fetal middle cerebral artery before and repeated 20 minutes after intravenous administration of 6 grams of magnesium sulphate (loading dose) over 20 minutes . fetal breathing movements and fetal gross movements are counted within 20 minutes, before and after intravenous administration of 6 grams of magnesium sulphate (loading dose) over 20 minutes

Official Title
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The Effect of Loading Dose of Magnesium Sulfate on Uterine, Umbilical, and Fetal Middle Cerebral Arteries Doppler, Biophysical Profile, CTG, Maternal Vital Signs in Women With Severe Preeclampsia

Conditions
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Preeclampsia

Intervention / Treatment
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* Drug: MgSO4


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Singleton pregnancy. Primigravida or Multigravida. Pregnant females ≥ 37 weeks of gestation. Diagnosed as severe preeclampsia by the following criteria: Sustained systolic blood pressure of ≥160 mmHg or a sustained diastolic blood pressure of ≥ 110 mmHg. Proteinuria measured as +1 or more by dipstick or 24 hours urine collection with proteinuria ≥ 0.3 grams. Oliguria or creatinine > 1.1 mg%. Laboratory findings characteristic of HELLP syndrome. Symptoms suggestive of severe preeclampsia ; severe headache, blurring of vision, epigastric pain. Exclusion Criteria: Multifetal pregnancy. History of epilepsy. Patients with diabetes. Patients with renal disease. Fetuses with congenital anomalies. Patients receiving anticoagulants e.g. heparin (unfractionated or low molecular weight). Patients with severe IUGR. Patients with accidental hemorrhage.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: MgSO4<br>The magnesium sulfate will be given according to the regimen of 6 grams intravenous over 20 minutes as a loading dose. | Drug: MgSO4<br>* The magnesium sulfate will be given according to the regimen of 6 grams intravenous over 20 minutes as a loading dose.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in uterine artery resistance index | Doppler assessment of uterine artey RI | 15 minutes after the loading dose of MgSO4 |