Assessment of Executive Functions After Covid-19

Study Overview
=================
Brief Summary
-----------------
As it is evident that Covid-19 may have some impacts on cognition, the primary aim of this study is to investigate -if any- deficits of attention, working memory and executive functions after Covid-19.

Detailed Description
-----------------
Since Covid-19 (Coronavirus Disease-2019) was declared as a pandemic by the World Health Organization (WHO) on December 31, 2019, it is still widespread and deadly. As an ongoing pandemic, it has led to a panic and then a controlled fear in societies. In many studies, neuropsychological deficits were observed in Covid-19 patients both during the illness and after recovery. A recent study found that impairment in cognitive functions continued after recovery of Covid-19, and it was associated with peripherical inflammatory markers, such as C-Reactive Protein (CRP). CRP, as a peripherical inflammatory marker, has been proven to be inversely related to serum levels of the brain-derived neurotrophic factor (BDNF), an important neurotrophin in the growth and differentiation of neurons. In this study, attention, working memory and executive functions of Covid-19 patients at post-covid period and its relation with the severity of the disease will be investigated.

Official Title
-----------------
May Covid-19 Impair Executive Functions? A Crossectional Study

Conditions
-----------------
Covid19, Cognitive Impairment

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Covid-19 patients: Diagnosed as Covid-19 by RT-PCR at least 60 days but not more than 90 days ago Asymptomatic at the moment Not having any other general medical, neurological or psychiatric conditions except Covid-19 at the time of acute infection Healthy subjects: Not having any of Covid-19 symptoms at the testing time point Not having any general medical, neurological or psychiatric condition Exclusion Criteria: Covid-19 patients: Diagnosed as Covid-19 by RT-PCR less than 60 days or more than 90 days ago Having any symptom of acute phase of Covid-19 Having any other general medical, neurlogical or psychiatric contidions Healthy subjects: Having any of Covid-19 symptoms at the testing time point Having any general medical, neurological or psychiatric condition

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients<br>Subjects who have been Covid positive by RT-PCR at least 60 days ago and not having any symptoms of Covid-19 at the moment | |
| Healthy<br>Subjects who do not have any general medical, neurological or psychiatric disorder | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Neuropsychological test scores | Neuropsychological test scores of Covid-19 patients in comparison with healthy control subjects | Up to 90 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Severity of the disease | Neuropsychological test score changes according to the disease severity of Covid-19 patients | Up to 90 days |