Effectiveness of Mulligan Mobilization Technique and Core Stabilization Exercise With Knee Osteoarthritis

Study Overview
=================
Brief Summary
-----------------
Osteoarthritis (OA) is a chronic disease process characterized by degeneration and inflammation in the joint cartilage and subchondral bone, synovial fluid and joint capsule. One of the most affected joints in OA is the knee joint, and the incidence of OA increases with age. Different treatment approaches are used in the treatment of osteoarthritis. The aim of the study is to examine the effectiveness of Mulligan technique and core exercises applied to female patients with knee osteoarthritis. In addition, the investigators did not find any study examining the effect of Mulligan technique on static balance in the treatment of OA. This is the secondary aim of the study.

Official Title
-----------------
Investigation of the Effectiveness of Mulligan Mobilization Technique and Core Stabilization Exercises in Female Patients With Knee Osteoarthritis: A Randomized Controlled Single-Blind Study.

Conditions
-----------------
Exercise

Intervention / Treatment
-----------------
* Other: Mulligan mobilization
* Other: Core stabilization
* Other: Conventional therapy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Being diagnosed with knee osteoarthritis To be in the age range of 40-70 No lower extremity surgery in the last 6 months. Agree to participate in the study Exclusion Criteria: Having had hip-knee replacement surgery Surgery planned in the last 6 months Having received physical therapy in the last 6 months Having uncontrollable hypertension and cardiac problems Having been diagnosed with rheumatoid arthritis

Ages Eligible for Study
-----------------
Minimum Age: 40 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Mulligan mobilization group<br>Painless movement | Other: Mulligan mobilization<br>* Mulligan mobilization technique will be apply.<br>|
| Experimental: Core stabilization group<br>Abdominal drawing-in maneuver | Other: Core stabilization<br>* Core stabilization technique will be apply.<br>|
| Active Comparator: conventional therapy group<br>Ultrasound TENS Hotpack | Other: Conventional therapy<br>* Conventional therapy exercise will be apply.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain assessment | Visual Analog Scale: This scale consists of a straight line with the end points defining extreme limits such as 'no pain at all', which is 0 cm, and 'pain as bad as it could be', which is 10cm. | 10 minutes | 
| Range of motion assessment | Goniometric measurement | 10 minutes | 
| muscle strength assessment | by handheld device (Commander Powertrack II brand) | 10 minutes | 
| functional level assessment | Western Ontario and McMaster Universities Arthritis Index (WOMAC) | 5 minutes | 
| aerobic endurance assessment | 6 minute walk test | 6 minutes | 
| balance assessment | Stand on one leg test | 5 minutes | 
| Timed Up& Go Test | Timed Up& Go Test | 5 minutes | 
| assessment of quality of life survey | Nottingham Health Profile | 5 minutes | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Pain, Joint, Mulligan, Core stabilization