Acute Effects of Propylene Glycol/Glycerol Intake on Blood Parameters

Study Overview
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Brief Summary
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The aim of this study is to evaluate the acute effect of propylene glycol and glycerol intake on cardiorespiratory blood parameters.

Detailed Description
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Background : Propylene glycol/glycerol intake is increasingly popular. Acute effect of propylene glycol and glycerol intake on cardiorespiratory blood parameters is unknown. The investigators postulate that intake of propylene glycol and glycerol could modifiy cardiorespiratory blood parameters. Aims of this study : to test the following hypotheses : 1) Acute intake of propylene glycol and glycerol modifies cardiorespiratory blood parameters. To test this hypothesis, we will perform blood samples before and after intake of propylene glycol and glycerol. Participants will be tobacco smoker between 18 and 70 years old, with multiple cardiovascular risk factors, and who will undergo a cardiac catherization. After the cardiac catherization, the catheter will be used to perform serial blood samples.

Official Title
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Acute Effects of Propylene Glycol/Glycerol Intake on Cardiorespiratory Blood Parameters

Conditions
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Metabolic Complication

Intervention / Treatment
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* Other: Propylene glycol and Glycerol intake
* Device: Mimicking intake


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Subject undergoing cardiac catherization Subject must be an active tobacco smoker Exclusion Criteria: Symptoms of infection or inflammation Acute disease including heart rhythm disorder, acute coronary syndrome or decompensation of a chronic disease (heart failure, COPD,...) Unexpected and undesirable effects during the cardiac catherization procedure Respiratory failure requiring supplementary oxygen

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Propylene glycol and Glycerol intake<br>One gram intake of a Propylene glycol/Glycerol mix (50:50) | Other: Propylene glycol and Glycerol intake<br>* Intake of 1 gram of propylene glycol/Glycerol mix (50:50). Blood sample before, 5 minutes and 20 minutes after intake.<br>|
| Placebo Comparator: Mimicking intake<br>Mimicking Propylene glycol/Glycerol intake with the device turns off | Device: Mimicking intake<br>* Mimicking propylene glycol/glycerol intake with the device turns off. Blood sample before, 5 minutes and 20 minutes after intake.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cardiorespiratory biological variables | Blood sample | 5 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cardiorespiratory biological variables | Blood sample | 20 minutes |