Lornoxicam With Low Dose Ketamine Versus Pethidine to Control Pain of Acute Renal Colic

Study Overview
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Brief Summary
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Patients with acute renal colic divided into 2 groups. Group L administered ornoxicam and Group P administered pethidine and VAS was recorded for both groups.

Detailed Description
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Prospective, randomized, double blind clinical study including 120 patients with acute renal pain admitted in emergency department. They were randomly assigned to one of two groups using a computer-generated table. Group L received lornoxicam 8 mg IV plus 0.15 mg.kg-1 ketamine and Group P received pethidine 50 mg IV. Parameters were observed at baseline and after 0, 15, 30, 45 and 1 hour of drug treatment. The efficacy of the drug was measured by observing: patient rated pain, time to pain relief, rate of pain recurrence, the need for rescue analgesia, adverse events and functional status.

Official Title
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Lornoxicam With Low Dose Ketamine Versus Pethidine to Control Pain of Acute Renal Colic

Conditions
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Renal Colic

Intervention / Treatment
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* Drug: Lornoxicam and mepridine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients, who did not administer any analgesics at least within the last two hours. - - Patients aged between 20-60 years. Exclusion Criteria: Patients with previous renal surgery liver and renal failure hypersensitivity to lornoxicam, ketamine and pethidine, history of peptic ulcer, gastrointestinal bleeding and perforation, hypertensive and history of cardiac diseases pregnancy and lactation and urine examination showing more than 5 leukocytes suggestive of pyuria. patients with hyperthyroidism are excluded

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Lornixicam<br>Patients received lornoxicam 8 mg intravenous to control pain | Drug: Lornoxicam and mepridine<br>* compare the effect of each to control pain<br>|
| Active Comparator: Pethidine<br>Patients received pethidine 50mg intravenous to control pain | Drug: Lornoxicam and mepridine<br>* compare the effect of each to control pain<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in pain feeling | We assess this through Visual analogue scale score to assess pain due to renal colic, number 10 means maximum pain feeling and 0 means no pain at all. | 0hours, 1hour,2hours,3hours,4hours after drug administration in both groups | 
| No need for more analgesics | Rescue analgesics administration | Registration of analgesic needed for 12h after the attack | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Renal pain, lornoxicam, pethidine, emergency room, ketamine