Effect of Different Infusion Volume on Perioperative Bladder and Blood Volume in Patients Undergoing Daytime Surgery.

Study Overview
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Brief Summary
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The objective of the trial was to explore the effect of different infusion volume on perioperative bladder and blood volume in patients undergoing daytime surgery assisted by bladder and vascular ultrasound and transthoracic echocardiography.

Detailed Description
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The objective of the trial was to evaluate the effects of different infusion volume of Ringer's solution acetate (2 ml/kg,8ml/kg, 16ml/kg) on bladder volume, hemodynamics,transthoracic echocardiography and vascular ultrasound including the inferior vena cava(IVC) and the right subclavian vein(SCV) diameter and the IVC and SCV collapsibility index in patients undergoing daytime surgery through a randomized controlled clinical study, so as to provide better guidance for clinical transfusion avoiding bladder catheterization . The patients in this trial were visited before induction and discharge from the postanaesthesia .We also collected the first time and times of micturition and whether the patients have the dysuria.

Official Title
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Effect of Different Infusion Volume on Perioperative Bladder and Blood Volume in Patients Undergoing Daytime Surgery.

Conditions
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Cholecystolithiasis and Thyroid Nodule

Intervention / Treatment
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* Drug: Ringer's solution acetate
* Drug: Ringer's solution acetate
* Drug: Ringer's solution acetate


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 1. ethnic Chinese; 2. age, 18 to 65 years old; 3. American Society of Anaesthesiologists (ASA) physical status I or II; 4. Daytime patients scheduled for general anesthesia Exclusion Criteria: Patients unwilling to cooperate with the experiment Body mass index exceeding 30 kg/m2; Patients with a history of heart ,liver and Renal failure ,hypertension,diabetes mellitus or arteriosclerosis; and any allergy to drugs used in the study. Patients with the urinary diseases, such as kidney, ureteral calculi and tumors, prostatic hypertrophy.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Doppler Ultrasonography Assessed Bladder and Blood Volume
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Group A: 2 ml/kg group<br> | Drug: Ringer's solution acetate<br>* Intravenous infusion of 2 ml/kg Ringer's solution acetate within 1 hour after induction.<br>|
| Experimental: Group B: 8 ml/kg group<br> | Drug: Ringer's solution acetate<br>* Intravenous infusion of 8ml/kg Ringer's solution acetate within 1 hour after induction.<br>|
| Experimental: Group C: 16 ml/kg group<br> | Drug: Ringer's solution acetate<br>* Intravenous infusion of 16ml/kg Ringer's solution acetate within 1 hour after induction.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 1. The change of bladder volume | bladder and blood volume in patients undergoing daytime surgery assisted by bladder and vascular ultrasound | baseline and 10 minutes before leaving the post-anesthesia care unite |