Exploration of Microcirculatory Alteration and Endothelial Dysfunction by Adaptive Optics in Multiple Sclerosis

Study Overview
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Brief Summary
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It's a pilot, interventional prospective monocentric study. It aims to compare the wall / lumen ratio (WLR) of retinal arterioles (common marker of microangiopathies) between patients with multiple sclerosis and controls using the technique of adaptive optics.

Official Title
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Exploration of Microcirculatory Alteration and Endothelial Dysfunction by Adaptive Optics in Multiple Sclerosis

Conditions
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Sclerosis, Multiple

Intervention / Treatment
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* Other: Ocular fundus on patient with Multiple Sclerosis
* Other: Ocular Fundus on voluntary person


Participation Criteria
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Eligibility Criteria
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Patient Inclusion Criteria Major patient between 18 and 50 years Patient with relapsing or remitting multiple sclerosis defined according to revised Mc Donald criteria 2010 Written, free and informed consent dated and signed Patient affiliated to a social security scheme Control Inclusion Criteria: Person between the ages of 18 and 50 Written, free and informed consent dated and signed Person affiliated to a social security scheme Person with multiple sclerosis Exclusion Criteria: Contraindication to the use oxygen (O2): Acute or chronic respiratory insufficiency Pregnant or lactating woman Inability to see fundus (cataract), retinopathy, glaucoma Use of vasoactive substances (eg nasal decongestants, triptans, alkaloids) in the last 48 hours Use of nonsteroidal anti-inflammatory drugs (ibuprofen, naproxen, ..) and steroids (corticosteroids) in the last 48 hours Known Diabetes or taking antidiabetics in the last 48 hours Use of statins in the last 48 hours Known hypertension or antihypertensive treatment in the last 48 hours Any cardiac pathology (valvulopathy, angina, ventricular arrhythmia or atrial fibrillation), vascular (arteritis obliterating the lower limbs, stenosis of the arteries with encephalic destiny, coronary artery disease) or significant respiratory (asthma, Chronic obstructive pulmonary disease, interstitial pathology) Alcohol consumption within 8 hours Ophthalmoparesis or incapacitating nystagmus (impossibility of correctly evaluating the fundus)

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Control Arm<br> | Other: Ocular Fundus on voluntary person<br>* Ocular Fundus on voluntary person<br>|
| Active Comparator: Multiple Sclerosis Arm<br> | Other: Ocular fundus on patient with Multiple Sclerosis<br>* Ocular fundus on patient with Multiple Sclerosis<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To compare the wall / lumen ratio (WLR) of retinal arterioles (common marker of microangiopathies) between multiple sclerosis patients and controls using the adaptive optics technique. |  | Day 0 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Compare between patients with multiple sclerosis and controls, retinal arteriolar gauges measured by external and internal diameter. |  | Day 0 | 
| Correlate possible changes in arteriolar WLR with internal and external diameter, smoking, age, blood pressure, fatigue (MFIS), cognition (MDT) and disability (EDSS) scores to ambient air and normobaric oxygen. |  | Day 0 |