Drug Reactions Sampling (COLLECTIONTOXIDERMIES)

Study Overview
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Brief Summary
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Intro: Dermatology department of Henri Mondor Hospital (Creteil, France), is a reference center for toxic bullous diseases and severe cutaneous drug reactions (Stevens-Johnson syndrome (SJS), Lyell syndrome (toxic epidermal necrolysis (TEN)), generalized bullous fixed drug reactions, AGEP, DRESS, drug induced immunoglobulin A (IgA) bullous dermatosis, and erythema multiforme). In order to conduct clinical and biological research studies in drug reactions, it is necessary for the investigator's department to implement a collection of clinical data and biological samples. Hypothesis/Objective: To collect clinical data and cutaneous and biological samples for immunological, biological and genetic studies to improve knowledge about pathophysiology of drug reactions. Method: The following samples will be performed in addition to the routine practice samples: one skin punch biopsy (6mm); 43 mL of blood; blister fluid aspiration; oral and nose mucous membrane and skin eSWABs, stool samples. These samples will be stored in a dedicated biological sampling department (Platform of biological resources). Conclusion: The implementation of this collection should allow us to conduct pathophysiological studies about drug reactions.

Official Title
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Adverse Cutaneous Drug Reactions Collection of Clinical Data and Biological Samples

Conditions
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Stevens-Johnson Syndrome, Lyell Syndrome, Drug Reactions, AGEP, DRESS, Bullous Dermatosis Caused by Drug Treatment (Disorder), Maculopapular Exanthem, Erythema Multiforme

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient ≥ 18 y-old Severe cutaneous drug reaction (AGEP, DRESS, SJS/TEN, generalized bullous fixed drug eruption), drug-induced IgA bullous dermatosis, maculopapular exanthema, erythema multiforme Signed consent Social security affiliation Exclusion Criteria: Patients law protection

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Implementation of a clinical data and biological samples collection for cutaneous adverse reactions | Implementation of a clinical data and biological samples collection for cutaneous adverse reactions | Day 0 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To conduct clinical and biological (immunological, histological, microbiological and genetic) studies in cutaneous adverse reactions. | To conduct clinical and biological (immunological, histological, microbiological and genetic) studies in cutaneous adverse reactions. | Day 0 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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AGEP, Drug reactions, severe cutaneous adverse reactions (SCARs, Stevens-Johnson syndrome, Lyell Syndrome, (generalized bullous) fixed drug reaction, DRESS, drug induced IgA bullous dermatosis, maculopapular exanthema, erythema multiforme, sampling, collection