linjc16/ctgov huggingface dataset:
Association Between Human Immunodeficiency Virus (HIV) Infection and Male Hypogonadism

Study Overview
=================
Brief Summary
-----------------
Cross-sectional study investigating the prevalence of hypogonadism in HIV-infected MSM population

Detailed Description
-----------------
In this study, we conduct a cross-sectional study investigating the prevalence of hypogonadism in HIV-infected MSM population. Age-matched non-HIV infected MSM group will be used as comparison group. We will also determine the risk factors associated with male hypogonadism (age, duration of HIV infection, comorbidities, BMI, ART use). Correlation will be made between serum testosterone levels and sexual function, vitality, exercise capacity, mood, and bone mineral density.

Official Title
-----------------
Association Between Human Immunodeficiency Virus (HIV) Infection and Male Hypogonadism

Conditions
-----------------
Hypogonadism; Ovarian

Intervention / Treatment
-----------------
* Diagnostic Test: Testosterone


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: HIV-infected men who have sex with men HIV non-infected men Exclusion Criteria: Use of testosterone supplement, anabolic steroid in the past one year. History of pituitary , adrenal or gonad diseases History of pituitary surgery or radiation therapy History of systemic chemotherapy Active opportunistic infection under treatment Cancer Severe hepatic, renal or cardiac impairment

Ages Eligible for Study
-----------------
Minimum Age: 20 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Case group<br>HIV infected men who have sex with men | Diagnostic Test: Testosterone<br>* Serum total testosterone and free testosterone level<br>|
| Control group<br>HIV non-infected men | Diagnostic Test: Testosterone<br>* Serum total testosterone and free testosterone level<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Symptoms of androgen deficiency | We use the score of Androgen Deficiency in Aging Males (ADAM) questionnaire to study the prevalence of hypogonadism in HIV-infected MSM population | 2021-2030 | 
| Serum free testosterone | We use serum free testosterone to study the prevalence of hypogonadism in HIV-infected MSM population | 2021-2030 |
Glucose, Activity, Diet, & Sleep Assessment Study

Study Overview
=================
Brief Summary
-----------------
GLADS is a cross-sectional, observational study assessing free-living diet, physical activity, sleep, and glucose profile over a 2-week period in healthy adult men and women.

Detailed Description
-----------------
Monitoring free-living lifestyle behaviors can provide important information on behavioral determinants of health. New technologies have improved accessibility of ambulatory assessment of diet, biomarkers, physical activity, and sleep. The study will assess the effects of free-living diet assessed by questionnaire and sleep and physical activity measured by actigraphy on interstitial glucose measured by continuous glucose monitoring in healthy adult men and women over a 2-week period.

Official Title
-----------------
GLADS Study: Glucose, Activity, Diet, & Sleep Assessment Study

Conditions
-----------------
Metabolism Disorder, Glucose

Intervention / Treatment
-----------------
* Other: Observational


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age: 18-75 y old In possession of a smartphone English speaking Live in New York City metro area Exclusion Criteria: Active food intake disorder

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Observational|Observation of diet, physical activity, sleep and interstitial glucose|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Glucose | Mean, fasting, post-prandial measured by continuous glucose monitoring | 2 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sleep duration | Measured by actigraphy | 2 weeks | 
| Sleep fragmentation | Measured by actigraphy | 2 weeks | 
| Diet composition | Carbohydrates, fats, proteins assessed by dietary recall | 2 weeks |
Ratio of the Cross Sectional Area of Median Nerve to Ulnar Nerve in Diagnosing Carpal Tunnel Syndrome

Study Overview
=================
Brief Summary
-----------------
An innovative diagnostic ultrasound method for carpal tunnel syndrome was proposed and compared between carpal tunnel syndrome patients and healthy volunteers.

Conditions
-----------------
An Innovative Diagnostic Method for Carpal Tunnel Syndrome

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: CTS patients were required to have subjective symptoms of numbness, tingling pain, or dysesthesia over the median nerve innervated area of the involved hand. Patients should have positive response in either Tinel's test or Phalen's test during physical examination Evidence of median neuropathy at wrist level in NCS. Control subjects should have neither symptoms nor signs of CTS along with no abnormal findings in electrodiagnostic study of the median nerve and the ulnar nerve across the wrist joint. Exclusion Criteria: Age younger than 20 years old Electrodiagnostic evidence of ulnar neuropathy at the wrist level Previous trauma or surgery history of hand Medical history of hypothyroidism, diabetes mellitus, uremia, rheumatoid arthritis, amyloidosis, and acromegaly Pregnancy

Ages Eligible for Study
-----------------
Minimum Age: 20 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| CTS group<br> | |
| Healthy subjects<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sonographical findings between hands with CTS and healthy hands |  | Within one week after ultrasound examination |
Endoscopic Preperitoneal Parastomal Hernia Repair (ePauli Repair)

Study Overview
=================
Brief Summary
-----------------
Observational study on laparoscopic and robotic extraperitoneal mesh repair of parastomal hernia, employing TAR.

Detailed Description
-----------------
Endoscopic trans-abdominal preperitoneal plasty (TAPP) for parastomal hernia employing transversus abdominis release component separation (TAR) and reinforcement with mesh after the Sugarbaker principle, but placing mesh extraabdominally, anteriorly to the transversalis fascia. Laparoscopic and robotic procedures. Repair of concomitant midline hernia with endoscopic enhanced-view Rives-Stoppa technique.

Official Title
-----------------
Endoscopic Preperitoneal Parastomal Hernia Repair (ePauli Repair)

Conditions
-----------------
Parastomal Hernia

Intervention / Treatment
-----------------
* Procedure: endoscopic preperitoneal repair of parastomal hernia


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: parastomal hernia with need of repair Exclusion Criteria: < 18 years
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: endoscopic preperitoneal repair of parastomal hernia|repair of parastomal hernia after the Sugarbaker principle with TAR and preperitoneal mesh reinforcement|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Adverse events | Per- and post-operative complications | 1 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Late complications | Stoma function, pain, mesh complications | 2 years | 
| Recurrence of hernia | Hernia recurrence | 2 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
hernia, parastomal, robotic, laparoscopic, transversus abdominis release, repair, incisional
Bioactive Glass Composite Implants in Cranial Bone Reconstruction

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to study composites of bioactive glass and methylmetacrylate with glass fibre reinforcement in cranial bone defect reconstruction.

Detailed Description
-----------------
Traditional skull and facial bone reconstructions with hard tissues have a long history with good clinical outcomes. However, they have certain disadvantages. The benefits of synthetic materials are the avoidance of donor-site morbidity and scars, but also shorter hospitalization time, lower expenses and known composition. Custom-made skull bone implant can produced based on patients clinical need utilizing rapid prototyping technologies. This will result in very high accuracy of the form of the skull defect. Polymethylmetacrylate (PMMA) is one of the most widely used alloplastic material in surgery. Bioactive glass S53P4 (BAG) particles have been used in various clinical indications. BAG was added to composite implant of PMMA with glass fibre reinforcement to enhance bone ingrowth to implant, and to utilize BAG's antimicrobial effects. Ten patients cranial defects are treated with composite implants.

Official Title
-----------------
Bioactive Glass Composite Implants in Cranial Bone Reconstruction

Conditions
-----------------
Bone Substitutes

Intervention / Treatment
-----------------
* Device: Composite Implant


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients with cranial bone defect larger than 4x4 cm after trauma or tumor surgery patient signs written study consent Exclusion Criteria: patient is unlikely to adhere to study procedures patient has a disease or condition that in the opinion of investigator is contraindicating participation patient is participating another medical device or drug trial

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Composite Implant<br>Subject receiving composite implant | Device: Composite Implant<br>* Subjects receiving composite implants<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical success | Clinical success is evaluated using clinical and radiographic examination, and blood count. | 3 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Cranial bone reconstruction, composite
Water Induced Thermogenesis in Obese Children

Study Overview
=================
Brief Summary
-----------------
Drinking water is largely advocated for obesity prevention and management. Recent studies have suggested that water has a thermogenic effect, this has not been examined in children. In this study, we will measure the resting metabolic rate of 21 obese children before, and during drinking cold (4 degrees centigrade)water for up to 60 minutes.

Official Title
-----------------
Water Induced Thermogenesis in Obese Children

Conditions
-----------------
Obesity

Intervention / Treatment
-----------------
* Other: Water


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: obesity agreement and informed consent Exclusion Criteria: non-agreement

Ages Eligible for Study
-----------------
Minimum Age: 6 Years
Maximum Age: 13 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Water<br>obese children (body mass index > 95th percentile for age and sex) that will drink cold water | Other: Water<br>* Children will drink 10 cc/kg of cold water(4 degrees centigrade)<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Post-drinking Metabolic Rate | resting metabolic rate after drinking water | 1 hour | 
| Baseline Metabolic Rate | baseline metabolic rate | baseline | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Resting metabolic rate
Effectiveness Registry to Study Therapies for Arthritis and Inflammatory Conditions: The Corrona CERTAIN Sub-study

Study Overview
=================
Brief Summary
-----------------
The CORRONA CERTAIN Sub-study of the Consortium of Rheumatology Researchers of North America, Inc. is a Sub-study of the CORRONA Data Collection Program. The CERTAIN Sub-study is designed to systematically collect and document use patterns, effectiveness, comparative effectiveness and safety of biologic agents used in the management of Rheumatoid Arthritis (RA).

Detailed Description
-----------------
Biologic therapies (including biologic medications like Enbrel, Humira, Remicade, Cimzia, Simponi, Actemra, Rituxan and Orencia) have changed the treatment of RA, but the differences in safety and/or effectiveness of each biologic therapy are not all known. We are doing this study in order to try to see if one or more of these treatments are better than the others. The use of databases like the CORRONA Organization database gives us information that helps us to understand why such drugs are used, reasons for starting or stopping drugs, for whom they are prescribed, and to monitor changes in patients' abilities to perform daily activities and gather information on family or social history.

Official Title
-----------------
The Corrona Effectiveness Registry to Study Therapies for Arthritis and Inflammatory Conditions Sub-study: The Corrona CERTAIN Sub-study

Conditions
-----------------
Rheumatoid Arthritis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: The CORRONA CERTAIN Sub-study is particularly focused on understanding the effectiveness and safety of biologic medications. Male and female patients, who are at least 18 years of age; have a documented diagnosis of RA by their treating rheumatologist; have at least moderate disease activity; and are initiating a biologic agent that has not be used for their treatment in the past are eligible to participate. Moderate disease activity is defined by a CDAI score greater than 10. Exclusion Criteria: Disease other than RA that do not meet the inclusion criteria

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Rheumatology<br>Patients who present at enrolling sites across the US are invited to enroll if eligible. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Rheumatoid Arthritis, Registry, RA, Biologic, Medications, Rheumatology
Yoga Efficacy and Bioactive Materials in the Blood of Korean Elderly

Study Overview
=================
Brief Summary
-----------------
This study is conducted to verify the relationships between yoga efficacy and bioactive materials in the blood of Korean elderly.

Detailed Description
-----------------
Glycoproteomics approach will be applied to verify the relationships between yoga efficacy and bioactive materials in the blood of Korean elderly.

Official Title
-----------------
The Studies of Yoga Efficacy and Bioactive Materials in the Blood of Korean Elderly

Conditions
-----------------
Yoga, Healthy Elderly

Intervention / Treatment
-----------------
* Behavioral: Participation in the elderly yoga program


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: The elderly group participant over 60 years old. The young group participant over 20 to 57 years old. Individual who can read and understand Korean. Participant is willing and able to give informed consent for participation in the study. Exclusion Criteria: Participant who was diagnosed with cancer in the last five years. In case of participants leaving the yoga program after the primary blood collecting, they will be excluded from the secondary blood collecting. Individuals who are judged inappropriate for the study.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Yoga participant groups<br>Yoga participant groups will practice elderly yoga for four months. We will collect their blood before and after their participation in the elderly yoga program. There will be two subgroups which are Advanced group and Beginner group. | Behavioral: Participation in the elderly yoga program<br>* Yoga participant groups will practice elderly yoga for four months.<br>|
| No Intervention: Non-Yoga participant groups<br>Non-Yoga participant groups will not practice yoga for four months and will be used as the control. We will collect their blood before and after the elderly yoga program. There will be two subgroups which are Elderly group and Young group. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measuring the number of glycoproteins in blood between before and after participation in an elderly yoga program for both the Advanced group and Beginner group | Glycoproteins in human plasma are known to be deeply associated with multiple diseases, cell differentiation, aging, and etc. The efficacy of elderly yoga will be assessed by identifying and comparing the number of glycoproteins in blood between before and after participation in an elderly yoga program for both the Advanced group and Beginner group. | 4 months |
Function and Structure Imaging in Different Retinal Diseases: Retinal Leakage Analyzer Versus Optical Coherence Tomography

Study Overview
=================
Brief Summary
-----------------
The main objective of this observational study is to characterize and correlate functional and structural changes at the retinal level using the Retinal Leakage Analyzer (RLA) and the Optical Coherence Tomograph (OCT). To show if it is possible to use OCT as an indirect measurement of leakage, this study will check, in a primary analysis, for OCT changes between fluorescein leaking and non-leaking areas (identified by Retinal Leakage Analyzer). As a secondary objective, changes in RLA and OCT over time (between two consecutive visits) will be analyzed and characterized. The results of this study will be used exclusively for scientific purposes.

Official Title
-----------------
Function and Structure Imaging in Different Retinal Diseases. Retinal Leakage Analyzer vs. Optical Coherence Tomography.

Conditions
-----------------
Diabetic Retinopathy, Age-Related Macular Degeneration, Macular Edema

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosis of DR, ARMD or ME Females or Males Age over 18 years Signed Informed Consent Form Exclusion Criteria: Cataract or other eye disease that may interfere with fundus examinations Vitreous syneresis or posterior vitreous detachment Dilatation of the pupil < 5 mm

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| DR<br>Diabetic Retinopathy | |
| ARMD<br>Age-Related Macular Degeneration | |
| ME<br>Macular Edema | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Retinal leakage and retinal thickness. |  | After the visit |
Dextroamphetamine as an Adjunct in Cocaine Treatment - 1

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate dextroamphetamine sulfate (sustained release) as an adjunct in cocaine treatment; an evaluation of the replacement strategy.

Official Title
-----------------
Dextroamphetamine as an Adjunct in Cocaine Treatment

Conditions
-----------------
Cocaine-Related Disorders, Substance-Related Disorders

Intervention / Treatment
-----------------
* Drug: Dextroamphetamine
* Drug: D-Amphetamine
* Drug: Placebo


Participation Criteria
=================
Eligibility Criteria
-----------------
Please contact site for information.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>15/30 mg d-amphetamine | Drug: Dextroamphetamine<br>* 15 mg for first 8 weeks and 30 mg for 2nd 8 weeks<br>|
| Experimental: 2<br>30/60 mg d-amphetamine | Drug: D-Amphetamine<br>* 30 mg for the first 8 weeks and 60 for the second 8 weeks (16 weeks total)<br>|
| Experimental: 3<br>placebo | Drug: Placebo<br>* Placebo<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| verifiable cocaine abstinence |  | 16 weeks of study | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
cocaine dependence