PRP Gel in Wound Closure in Recurrent CS

Study Overview
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Brief Summary
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There is limited application of the use of PRP in obstetrics, therefore there is a need for assessment if it is efficacy in improving skin wound healing in cesarean section.

Detailed Description
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This study aims to assess the efficacy of injection of platelet rich plasma into the wound of recurrent cesarean section for improving wound healing and enhancing the shape of the wound in women undergoing cesarean section.

Official Title
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Platelet Rich Plasma Gel in Wound Closure in Recurrent Cesarean Section:Randomized Controlled Trial

Conditions
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Previous Incision, Scar; Previous Cesarean Section

Intervention / Treatment
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* Biological: platelet rich plasma gel
* Biological: saline


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: elective cesarean section Body mass index 18:25 Hemoglobin more than 10.5 g/d Albumin within normal more than or equal 3.5 g/d Exclusion Criteria: medical disorders(Diabetes mellitus,heart disease,hypertension,systemic lupus erythematosus) high risk pregnancy as (placenta previa,placenta accreta) patient on corticosteroids medication primigravida subjected cesarean section complicated cesarean section (increased operation time,blood transfusion, drain, scrubbing of multiple surgeons) cesarean section due to chorioaminionitis postoperative complication such as:postpartum hemorrhage, paralytic ileus, sever distention..) will be dropped out from the study

Ages Eligible for Study
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Minimum Age: 25 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: platelet rich plasma gel<br>Injection of Platelet rich plasma (PRP) gel in 64 cases at time of wound closure in women undergoing cesarean section for improving wound healing after fullfit to all the inclusion and exclusion craiteria | Biological: platelet rich plasma gel<br>* Platelet rich plasma is prepared from fresh whole blood which is collected from a peripheral vein stored in acid citrare dextrose solution A (ACD-A)anticoagulant and processed to increase platelets by separating various components of blood<br>* Other names: platelete rich plasma (PRP);|
| Placebo Comparator: Saline<br>64 Controlled Women with recurrent cesarean section and fullfit to all the inclusion and exclusion craiteria will reseve saline injection at time of wound closure | Biological: saline<br>* 64 controlled women with recurrent cesarean section and fullfit to all inclusion and exclusion craiteria will reseve saline injection at time of wound closure<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Efficacy of PRP in Wound healing in cesarean section by 100 mm visual analog scale | Efficacy of PRP in Wound healing in cesarean section by 100 mm visual analog scale (VAS) for wound healing | one month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Assessment of the Cosmetic results of the wound by Modified Vancouver scar scale | Assessment of the Cosmetic results of the wound by Modified Vancouver scar scale | one month |