Autonomic Nervous System Activity, Aging and Sleep Apnea/Hypopnea

Study Overview
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Brief Summary
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The regulatory effects of the autonomic nervous system (ANS) concern almost all organs which permanently feed information back to this global biological vigilance system controlling allostasis. Heart rate fluctuations are highly dependent on ANS control, making the heart one of the best indicators of ANS activity. Low ANS activity level is associated with severe cardiac and cerebral events, as well as to death from any cause in the general population. It is even associated with sleep apnea/hypopnea.

Detailed Description
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The main goal of this SYNAPSE study is to evaluate, on a selected prospective cohort of subjects aged 67 years upon study entry, the incidence of sleep apnea/hypopnea and the prognostic values of ANS activity levels measured at preset times and of cardiovascular or cerebrovascular events.

Official Title
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Autonomic Nervous System Activity, Aging and Sleep Apnea/Hypopnea in a Prospective Cohort of Subjects Aged 67 Years

Conditions
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Healthy

Intervention / Treatment
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* Other: Sleep apnea/hypopnea detection


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: informed consent signed to participate in the PROOF study Exclusion Criteria: prior myocardiac infarction prior stroke hearth failure atrial fibrillation insulin-treated diabetes mellitus cardiac pacemaker disease limiting life expectancy to < 5 years contraindication to brain MRI living in an institution respiratory failure with oxygenotherapy sleep-related breathing disorders known and treated

Ages Eligible for Study
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Minimum Age: 67 Years
Maximum Age: 68 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| PROOF cohort<br>This cohort is the same than the PROOF study (NCT00759304). Subjects were recruited amongst the inhabitants of the city of Saint-Etienne, France, and were eligible if aged 65 at the inclusion date in the PROOF study | Other: Sleep apnea/hypopnea detection<br>* Simultaneous 24-hour ambulatory electrocardiogram and polygraphic recordings performed at home during a night.<br>* Other names: HypnoPTT, Tyco Healthcare, USA;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Composite criterion : fatal and non-fatal cardiovascular or cerebrovascular events |  | During all the study | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Presence and relationship of sleep apnea/hypopnea and clinically silent stroke revealed through brain MRI |  | Years 1, 3, 5, 7 and 9 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Aging, Autonomic nervous system, stroke, Myocardiac infarction, Prospective cohort, Sleep apnea/hypopnea