Effects of Nicotinamide Riboside on Metabolism and Vascular Function

Study Overview
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Brief Summary
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The purpose of this study is to determine the effects of Nicotinamide Riboside (NR) supplementation on metabolism and vascular function following high-fat meal. Differences between young (18-35) and older (60-75) adults will be determined.

Detailed Description
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The purpose of this study is to determine the effects of 7 days of Nicotinamide Riboside (NR) or placebo supplementation on metabolism and vascular function following high-fat meal. Differences between young (18-35) and older (60-75) adults will be determined.

Official Title
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Effects of Nicotinamide Riboside on Metabolism and Vascular Function

Conditions
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Aging, Lipemia

Intervention / Treatment
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* Dietary Supplement: Nicotinamide riboside chloride (Niagen)
* Dietary Supplement: Placebo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 18 to 35 (young) and 60 to 75 (older) Normo- or pre-hypertensive (blood pressure <140/90 mmHg) Non-smokers Able to give informed consent and participate in all laboratory visits Exclusion Criteria: Currently taking any medications that could interfere with cardiovascular or metabolic outcomes will be excluded from the study (e.g., beta-blockers) Known metabolic (e.g. Type I or Type II diabetes, cardiovascular disease, etc.) or immunologic (e.g. HIV, cancer, autoimmune, etc.) diseases Food allergies to egg, milk, soy or wheat Women who are pregnant or planning to become pregnant during the course of the study, Pacemaker or other implanted device Unwilling to participate in the experimental protocol or blood draws will be excluded

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Interventional Model Description: Randomized, cross-over
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Nicotinamide Riboside Chloride (Niagen)<br>7 days of nicotinamide riboside supplementation (250 mg/d x 2/day). | Dietary Supplement: Nicotinamide riboside chloride (Niagen)<br>* 250 mg capsules 2x/day for 7 days<br>* Other names: Nicotinamide Riboside, Niagen;|
| Placebo Comparator: Placebo<br>7 days of placebo supplementation (2/day) | Dietary Supplement: Placebo<br>* 2x/day for 7 days<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| NAD+ | Blood and peripheral blood mononuclear cell (PBMC) levels | 7 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Vasodilatory responsiveness | Post-Occlusion Reactive Hyperemia (PORH) | 7 days | 
| Lipdemia | Fasting and postprandial | 7 days | 
| Oxidative stress and inflammation | Plasma markers and expression in circulating PBMCs | 7 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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postpandial, lipemia, microvascular