Collecting and Storing Blood and Brain Tumor Tissue Samples From Children With Brain Tumors

Study Overview
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Brief Summary
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The purpose of this study is to collect and store brain tissue samples and blood from children with brain cancer that will be tested in the laboratory. Collecting and storing samples of tumor tissue and blood from patients to test in the laboratory may help the study of cancer in the future.

Detailed Description
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OBJECTIVES: I. Collect brain tumor tissue and an accompanying blood sample from pediatric patients with brain tumors treated at Children?s Oncology Group institutions. II. Provide a repository for long-term storage of specimens from these patients. III. Make these specimens available to qualified researchers to understand the biology of pediatric brain tumors. OUTLINE: This is a multicenter study. Brain tumor tissue and blood specimens are collected from patients and banked for future study.

Official Title
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A Children's Oncology Group Protocol for Collecting and Banking Pediatric Brain Tumor Research Specimens

Conditions
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Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Germ Cell Tumor, Childhood Cerebral Anaplastic Astrocytoma, Childhood Cerebral Astrocytoma, Childhood Choroid Plexus Neoplasm, Childhood Craniopharyngioma, Childhood Grade I Meningioma, Childhood Grade II Meningioma, Childhood Grade III Meningioma, Childhood Infratentorial Ependymoma, Childhood Oligodendroglioma, Childhood Supratentorial Ependymoma, Ependymoma, Newly Diagnosed Childhood Ependymoma, Recurrent Childhood Cerebellar Astrocytoma, Recurrent Childhood Cerebral Astrocytoma, Recurrent Childhood Ependymoma, Recurrent Childhood Medulloblastoma, Recurrent Childhood Supratentorial Embryonal Tumor, Not Otherwise Specified, Recurrent Childhood Visual Pathway Glioma

Intervention / Treatment
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* Other: Cytology Specimen Collection Procedure


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosis of brain tumor Previously treated at a Children?s Oncology Group (COG) institution Patients are eligible at time of diagnosis, second-look surgery, recurrence, or development of a second malignant neoplasm Must have brain tumor biological specimens derived from primary tumors of the CNS available for submission

Ages Eligible for Study
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Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Ancillary-Correlative (tissue and blood sample collection)<br>Brain tumor tissue and blood specimens are collected from patients and banked for future study. | Other: Cytology Specimen Collection Procedure<br>* Correlative studies<br>* Other names: Cytologic Sampling;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Collection of brain tumor tissue and an accompanying blood sample from pediatric patients with brain tumors treated at Children?s Oncology Group institutions |  | Up to 16 years | 
| Creation of a repository for long-term storage of these specimens |  | Up to 16 years | 
| Making these specimens available to qualified researchers to understand the biology of pediatric brain tumors |  | Up to 16 years |