linjc16/ctgov huggingface dataset:
The Pathogenesis of Human Senile Cataract

Study Overview
=================
Brief Summary
-----------------
To study the pathological mechanism of cataract by genomics, transcriptomics, and proteomics.

Detailed Description
-----------------
Tissue samples and aqueous humor samples will be collected from each individual patients by cataract surgery. After sample treatment, different techniques will be applied for analysis. And bioinformatics approach is applied for data treatment and analysis.The data of genomics, transcriptomics, and proteomics will be analyzed for study of pathological mechanism of cataract.

Official Title
-----------------
The Pathogenesis of Age-related Cataract

Conditions
-----------------
Cataract

Intervention / Treatment
-----------------
* Procedure: phacoemulsification


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with the explicit diagnosis of cataract (including senile cataract, congenital cataract, complicated cataract, metabolic cataract, traumatic cataract, etc.) in the operated eye are willing to undergo cataract surgery. Exclusion Criteria: Patients whose cataracts need not be operated Patients with any contraindications to cataract surgery Patients are unwilling to undergo cataract surgery

Ages Eligible for Study
-----------------
Minimum Age: 5 Years
Maximum Age: 94 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| cataract in old age<br> | Procedure: phacoemulsification<br> <br> |
| cataract in young age<br> | Procedure: phacoemulsification<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Characterization of miRNA in micro-scale human aqueous humor | method development for miRNA detection in aqueous humor | 12 month | 
| Favored amplification recovery via protection-chromatin immunoprecipitation-Seq of human eye tissue samples | low-cell-number epigenome profiling for study of cataract | 24 month | 
| Study of cataract by genomics, transcriptomics, and proteomics approaches | detect histone H3 lysine 4 trimethylation (H3K4me3) of aqueous humor of cataract patients by genomics, transcriptomics, and proteomics methods | 36 month |
Intestinal Dysmotility: Effect of Colonic Load

Study Overview
=================
Brief Summary
-----------------
Abnormal motility patterns in the jejunum can be detected in patients with prominent colonic distension, and it is not clear whether these abnormalities reflect a primary jejunal dysfunction or are due to a reflex distortion. The aim of the study is to determine the effect of colonic filling on jejunal postprandial motility using high-resolution manometry. Healthy subjects will be studied following a controlled, parallel, randomized, single-blind experimental design. On the study day, nutrients will be continuously infused in the proximal jejunum (2 Kcal/min) during a 2-h period to induce a steady-state postprandial motor pattern. Jejunal motility will be concomitantly recorded using a water-perfused, high-resolution manometry catheter. After 1 hour of postprandial recording (basal period), a gas mixture will be infused during 7.5 minutes via a rectal tube (720 mL or sham infusion), and jejunal motility will be recorded for another hour.

Official Title
-----------------
Intestinal Dysmotility in Patients With Functional Digestive Symptoms

Conditions
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Healthy Volunteers

Intervention / Treatment
-----------------
* Other: Colonic gas load
* Other: Sham load


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: No digestive symptoms Exclusion Criteria: Organic diseases

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Colonic gas load<br> | Other: Colonic gas load<br>* Colonic infusion of gas via an anal cannula<br>|
| Sham Comparator: Sham<br> | Other: Sham load<br>* Sham infusion of gas via an anal cannula<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Small bowel contractility | Number of contractions | 10 minutes |
Blood Loss Evaluation Using a Novel Device

Study Overview
=================
Brief Summary
-----------------
The study´s aim is to evaluate the clinical applicability of the Feature Extraction Technology (FET) during a simulated blood loss scenario.

Detailed Description
-----------------
In an operating theatre blood loss will be simulated in different scenarios. Expired whole blood donations (provided by the German Red Cross, Institute of Transfusions Medicine, Goethe University Frankfurt) will be used. Blood will be diluted by full electrolyte solutions . Sponges and canisters will be prepared with a predetermined amount of blood. Study participants will estimate total blood loss on sponges and canisters. Study members not knowing the correct amount of prepared blood will measure the blood loss in sponges and canisters by Feature Extraction Technology (FET) and by gravimetric method before and after estimation of the participants.

Official Title
-----------------
Quantification of Blood Loss Using a Novel Device in Comparison to Visually Estimated Blood Loss in a Simulated Blood Loss Scenario

Conditions
-----------------
Blood Loss, Surgical, Transfusion, Patient Blood Management

Intervention / Treatment
-----------------
* Diagnostic Test: Feature Extraction Technology


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Health care professionals Exclusion Criteria: None

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: Feature Extraction Technology|The study´s aim was evaluation of the clinical applicability of the Feature Extraction Technology (FET) during a simulated blood loss scenario in comparison to visual estimation.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Estimated blood loss | Visual versus novel device estimated blood loss | 02.05.2020 - 03.15.2020 |
Outcomes of 20 and 23-gauge Combined Transconjunctival Pars Plana Vitrectomy

Study Overview
=================
Brief Summary
-----------------
In a retrospective study, a combined 20 and 23-gauge pars plana vitrectomy procedure was performed in 21 eyes for various indications and proposed as a transition procedure to 23-gauge transconjunctival vitrectomy. Through use of combination of procedures postoperative complications, surgical trauma and healing time was decreased; operating time was reduced; costs were decreased.

Official Title
-----------------
Outcomes of 20 and 23-gauge Combined Transconjunctival Pars Plana Vitrectomy

Conditions
-----------------
Vitrectomy

Intervention / Treatment
-----------------
* Procedure: 20 and 23 gauge pars plana vitrectomy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: eyes requiring pars plana vitrectomy for various indications: such as dropped lens, intraocular blood, retinal detachments...etc. Exclusion Criteria: patients who did not observed periodically during postoperative period.

Ages Eligible for Study
-----------------
Minimum Age: 44 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| vitrectomy<br> | Procedure: 20 and 23 gauge pars plana vitrectomy<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| visual acuity |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| postoperative complications |  |  |
A Study to Evaluate the Efficacy and Safety of Renexin CR in Patients With Acute Non-cardioembolic Ischemic Stroke

Study Overview
=================
Brief Summary
-----------------
A study to Evaluate the Efficacy and Safety of Renexin CR in patients with Acute Non-cardioembolic Ischemic Stroke

Official Title
-----------------
A Prospective, Randomized, Active-controlled, Double-blind, Parallel, Multi-center, Phase IV, Exploratory Study to Evaluate the Efficacy and Safety of Renexin CR in Patients With Acute Non-cardioembolic Ischemic Stroke

Conditions
-----------------
Ischemic Stroke

Intervention / Treatment
-----------------
* Drug: Renexin CR 200/160mg
* Drug: Plavix 75mg


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 1) Patients identified as acute non-cardioembolic ischemic stroke on MRI within 72 hours of onset of symptoms of cerebral infarction. Exclusion Criteria: Patients with active cancer; vascular malformation, abscess, or other major non-ischemic brain disease (e.g., multiple sclerosis). With a modified Rankin Score (mRS) of 3 or higher before onset. Underwent intravenous thrombolytic therapy (intravenous rtPA) or mechanical thrombectomy within 24 hours of the screening visit. History of hypersensitivity to IP or components Not suitable for aspirin administration at the discretion of the investigator

Ages Eligible for Study
-----------------
Minimum Age: 20 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Renexin CR 200/160mg<br>Renexin CR 200/160mg will be added to Aspirin 100mg | Drug: Renexin CR 200/160mg<br>* Renexin CR 200/160mg will be added to Aspirin 100mg<br>|
| Active Comparator: Clopidogrel 75mg<br>Plavix 75mg will be added to Aspirin 100mg | Drug: Plavix 75mg<br>* Plavix 75mg will be added to Aspirin 100mg<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| - The sum of the rate of neurological deterioration during hospitalization after taking the IP and the rate of stroke up to 90 days |  | up to 90 days |
Procure Tumor and Initiate Melanoma Tumor-Reactive Tumor Infiltration

Study Overview
=================
Brief Summary
-----------------
Procure Tumor and Initiate Melanoma Tumor-Reactive Tumor Infiltration Lymphocytes (TIL)

Detailed Description
-----------------
The purpose of this study is to allow the collection of tissue from subjects to be used in future research studies by scientists and to isolate tumor fighting cells for the future treatment of Melanoma.

Official Title
-----------------
Procure Tumor and Initiate Melanoma Tumor-Reactive Tumor Infiltration

Conditions
-----------------
Melanoma

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients must have metastatic melanoma with a resectable metastasis who are undergoing resection for palliation, therapeutic or curative purpose. Patients must be > 15 years of age and must have metastatic melanoma. Patients must meet standard pre-operative requirements as determined by the surgeon to be candidates for surgery. Patients must be able to understand and sign the Informed Consent document. Patients must be able to complete the supplemental data form Exclusion Criteria: women who are pregnant or breastfeeding inability to give consent

Ages Eligible for Study
-----------------
Minimum Age: 15 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluate Feasibility of conducting TIL procurement in a single-site setting | Cell viability, viable number and TIL potency using standardized methods | 5 years | 
| Evaluate Safety of conducting TIL procurement in a single-site setting | lab personnel training during procurement, isolation, testing tumor reactivity and cryopreservation | 5 separate TIL procedures | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To determine whether TIL Procurement, isolation, testing tumor reactivity and cryopreservation can be performed at John Wayne Cancer Institute (JWCI) and Providence Saint John's Health Center (PSJHC) and infused into patients |  | 5 years |
Paramedic - Norwegian Acute Stroke Prehospital Project

Study Overview
=================
Brief Summary
-----------------
The main aim of the study is to show that patients with suspected acute stroke met by the emergency medical service and assessed using the eSTROKE model including prehospital NIHSS and a mobile application will identify a higher number of patients with stroke, than those who receive conventional prehospital care.

Detailed Description
-----------------
Primary aims: In patients with suspected stroke The proportion of patients hospitalized with a suspected acute stroke and discharged with a stroke diagnose is significantly increased using the ParaNASPP model compared with conventional prehospital care Time from onset to hospitalization is significantly reduced with the ParaNASPP model The ParaNASPP model identifies patients eligible for direct transportation for comprehensive stroke center

Official Title
-----------------
Diagnostics and Triage of Acute Stroke by the National Institute of Stroke Scale (NIHSS) by Paramedics, the ParaNASPP (Paramedic - Norwegian Acute Stroke Prehospital Project) Study

Conditions
-----------------
Stroke, Triage, Paramedic, Mobile Application

Intervention / Treatment
-----------------
* Diagnostic Test: eSTROKE model
* Other: Control


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All patients with suspected acute stroke met by emergency medical services (ambulance and rapid response car)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Single Group Assignment
Interventional Model Description: ParaNASPP is a stepped wedge cluster randomized controlled intervention trial (SW-RCT).
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: eSTROKE<br> | Diagnostic Test: eSTROKE model<br>* The eSTROKE model includes an electronic learning module, a full day course with practical teaching of National Institute of Health Stroke Scale and a mobile application which will be used for communication with in-hospital stroke physician<br>* Other names: ParaNASPP;|
| Active Comparator: Control<br>Conventional prehospital care | Other: Control<br>* Conventional prehospital care<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Positive predictive value (PPV) of the ParaNASPP model to identify patients suffering acute stroke. |  | On discharge from hospital - typically within 7 days. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patients in hospitalized within the first 4 hours after symptom onset |  | first 4 hours On admission |
The Association of Pelvic Organ Prolapse Severity and Urinary Symptoms/Sexual Function

Study Overview
=================
Brief Summary
-----------------
Women with pelvic organ prolapse often accompany with urinary symptoms or sexual dysfunction, and analyzing the association will be helpful to identify the indication of proper management. Therefore, the aim of this study is to identify the above associations.

Conditions
-----------------
Pelvic Organ Prolapse

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: all cases with with pelvic organ prolapse Exclusion Criteria: nil

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 99 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
pelvic organ prolapse, urinary symptoms, sexual function
Evaluation of Two Daily Disposable Contact Lenses for Wearers With Astigmatism

Study Overview
=================
Brief Summary
-----------------
The purpose of this trial is to compare the performance of two contact lenses for contact lens wearers with astigmatism.

Conditions
-----------------
Astigmatism, Myopia

Intervention / Treatment
-----------------
* Device: Nelfilcon A investigational contact lens
* Device: Nelfilcon A commercial contact lens


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Currently wearing soft contact lenses with astigmatism correction Other protocol inclusion criteria may apply Exclusion Criteria: Eye injury or surgery within twelve weeks prior to enrollment Currently enrolled in an ophthalmic clinical trial Strabismus Any use of medications for which contact lens wear could be contraindicated as determined by the investigator Other protocol exclusion criteria may apply
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Nelfilcon A invest'l / nelfilconA comm'l<br>Nelfilcon A investigational toric contact lenses worn first, with nelfilcon A commercial toric contact lenses worn second. Each product worn bilaterally on a daily disposable basis for one week. | Device: Nelfilcon A investigational contact lens<br>* Investigational, soft contact lens for astigmatism worn on a daily disposable basis.<br>Device: Nelfilcon A commercial contact lens<br>* Commercially marketed, soft contact lens for astigmatism worn on a daily disposable basis.<br>* Other names: Focus DAILIES Toric;|
| Other: Nelfilcon A comm'l / nelfilconA invest'l<br>Nelfilcon A commercial toric contact lenses worn first, with nelfilcon A investigational toric contact lenses worn second. Each product worn bilaterally on a daily disposable basis for one week. | Device: Nelfilcon A investigational contact lens<br>* Investigational, soft contact lens for astigmatism worn on a daily disposable basis.<br>Device: Nelfilcon A commercial contact lens<br>* Commercially marketed, soft contact lens for astigmatism worn on a daily disposable basis.<br>* Other names: Focus DAILIES Toric;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quality of Vision (Crisp and Clear) | Quality of vision (crisp and clear), as interpreted and reported by the participant by eye on a questionnaire as a single, retrospective evaluation of one week's wear time. Quality of vision was assessed on a 10-point scale, with 1 being poor and 10 being excellent. | 1 week of wear |
Placement of Permanent Pacemaker Study

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine the predictors for placement of permanent pacemakers soon after cardiac surgery. We will measure the following to see what influence, if any, they have on predicting the need for permanent pacemaker implantation. Type of cardiac surgery Gender of patient Patient's age Preoperative heart rhythm and rate Duration on cardiopulmonary bypass Immediate post cardiopulmonary bypass heart rhythm and rate. All heart rhythms and rates identified in the postoperative period prior to permanent pacemaker implantation. Underlying heart rhythm and rates when permanent pacemaker is placed. Ejection fraction before surgery Ejection fraction immediately post-cardiopulmonary bypass

Detailed Description
-----------------
The purpose of this study is to determine the predictors for placement of permanent pacemakers soon after cardiac surgery. We will measure the following to see what influence, if any, they have on predicting the need for permanent pacemaker implantation. Through investigation into the co-morbidities, diagnoses, or histories associated with an endpoint permanent pacemaker placement, it is possible that we will garner a better idea of who will require PPP.

Official Title
-----------------
A Retrospective Study to Determine the Frequency of Indications That Lead to the Placement of Permanent Pacemakers After Cardiac Surgery

Conditions
-----------------
Cardiac Surgical Procedures

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All patients between the ages of 18-99 years. All patients undergoing cardiac surgery requiring cardiopulmonary bypass. Exclusion Criteria: Patients who have permanent pacemakers in place.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Any patient undergoing elective cardiac surgery