Periodization of Exercise Training in Patients With Coronary Heart Disease.

Study Overview
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Brief Summary
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The research project includes two components that assess exercise physiology parameters, cerebrovascular reserve, cognitive functions and cardiac function in coronary heart disease patients at rest, during an acute exercise, and after two different periodized training programs.

Official Title
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The Effects of Periodization Training on Physiological Parameters, Cerebral Oxygenation, Cognitive Functions and Cardiac Remodelling in Coronary Patients.

Conditions
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Coronary Heart Disease, Healthy Control

Intervention / Treatment
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* Other: Exercise training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria for patients with coronary heart disease: Major Adequate physical and mental capacities Autonomy in daily activities Documented coronary artery disease Stable or recent coronary artery disease Exclusion Criteria for patients with coronary heart disease: Inability to complete the consent form Acute coronary syndrome < 3 months Heart failure Ejection fraction of the left ventricle <40% Coronary artery disease non revascularisable including left main coronary stenosis Waiting for a bridging of the coronary artery Chronic atrial fibrillation Malignant arrhythmias during exercise Restriction to non cardiopulmonary exercise Severe intolerance to exercise

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Linear training<br>Linear training consists to a progressive improvement of the training load during the 3 month-program. | Other: Exercise training<br>* Patients will undergo three weekly exercise training sessions with periodized high-intensity interval training and resistance training for a period of 12 weeks.<br>|
| Experimental: Non-linear training<br>Non-linear training consists to an undulating progressive improvement of the training load during the 3 month-program. | Other: Exercise training<br>* Patients will undergo three weekly exercise training sessions with periodized high-intensity interval training and resistance training for a period of 12 weeks.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Maximal oxygen uptake (VO2peak) with gas exchange | VO2peak will be measured during maximal exercise test with a gas exchange device. The highest value reached during the exercise phase of the maximal test (ergocycle) will be considered as the VO2peak. We will measure change of VO2peak before and after exercise training. | At baseline and following 12 weeks exercise training intervention | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cerebral hemodynamics | Cerebral hemodynamics will be measured using near-infrared spectroscopy (NIRS) system during maximal and submaximal exercise tests. We will measure change of cerebral hemodynamics before and after exercise training | At baseline and following 12 weeks exercise training intervention | 
| Cognitive functions at rest by a by standard pen-paper battery test | Cognitive functions will be measured at rest with a pen-paper battery test by a neuropsychologist. We will measure change of score to the cognitive tests before and after exercise training. | At baseline and following 12 weeks exercise training intervention | 
| Cardiac hemodynamics | Cardiac hemodynamics will be measured continuously during the maximal exercise test on bike using an impedance cardiography device. We will measure change of cardiac hemodynamics before and after exercise training. | At baseline and following 12 weeks exercise training intervention | 
| Standard echocardiographic parameter of left and right ventricular strain | global longitudinal strain (%) will be measued at rest for both ventricule | At baseline and following 12 weeks exercise training intervention | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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aerobic exercise training, periodization, cerebral oxygenation and perfusion, cognition