Effects of Adapated Physical Activity Program on Kynurenin Metabolism During Refeeding in Anorexia Nervosa : APANOR Study

Study Overview
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Brief Summary
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Physical hyperactivity is often associated to anorexia nervosa (AN). Data suggest common central pathways between hyperactivity and anorexia. Maintaining adapted physical activity (APA) during refeeding in AN is controversial. Many studies suggest beneficits of APA in AN on body composition (increase fat free mass and better distribution of fat mass), mood regulation, bone metabolism. We recently reported benefits of maintaining physical activity during refeeding in a mice model of anorexia (activity-based anorexia model). These benefits involved the tryptophan-kynurenin pathway. Thus, we aim in the APANOR study to assess effects of APA during refeeding in AN on kynurenin metabolism.

Official Title
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Effects of Adapated Physical Activity Program on Kynurenin Metabolism During Refeeding in Anorexia Nervosa : APANOR Study

Conditions
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Anorexia Nervosa

Intervention / Treatment
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* Other: physical activity program (APA)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Female Patient > 18 years Follow-up in the department of clinical Nutrition of Rouen BMI ≥15,0 and <18,5 kg/m² Diagnosis of anorexia nervosa according to DSM-V classification Exclusion Criteria: Physical activity contraindications : hemodynamic disorder, uncontrolled cardiovascular disease, intracranial hypertension Patients with poor understanding of spoken or written French Person deprived of their liberty by an administrative or judicial decision or person subject to a legal measure for the protection of adults Person subject to a safeguard of justice, guardianship or curatorship. Pregnant or breastfeeding woman

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Without adapted physical activity program (APA)<br> | Other: physical activity program (APA)<br>* adapted physical activity program (APA)<br>|
| Experimental: With adapted physical activity program (APA)<br> | Other: physical activity program (APA)<br>* adapted physical activity program (APA)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To evaluate the effects of adapated physical activity (APA) program on kynurenin metabolism | Variation of plasmatic kynurenin acid between V1 and V2 in patients undergoing APA during refeeding versus other patients (control group without APA) | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To evaluate the effects of adapated physical activity program on anthropometric data. | Anthropometric data | 3 months | 
| To evaluate the involving of gut microbiota composition and diversity | gut microbiota analyses | 3 months | 
| To evaluate the effects of adapated physical activity program on quality of life | Self-administered questionnaires assessing the quality of life | 3 months | 
| To evaluate the involving of auto-antibodies against neuropeptides involved in food intake regulation | Dosage of auto-antibodies against neuropeptides involved in food intake regulation using ELISA method (enzyme-linked immunosorbent assay) | 3 months | 
| To evaluate the effects of adapated physical activity program on Body composition (fat mass, fat free mass) | Mesaurement of fat and free mass | 3 months |