Internet-delivered Psychodynamic Therapy for Depression

Study Overview
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Brief Summary
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The overall aim of this study is to develop and test a psychodynamic Internet-delivered psychological treatment for patients with mild to moderate major depression and compare its efficacy to an active control group.

Official Title
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Internet-delivered Psychodynamic Therapy for Depression: a Randomized Controlled Trial

Conditions
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Depression

Intervention / Treatment
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* Behavioral: Internet-delivered psychodynamic therapy for depression
* Behavioral: Internet-delivered therapist support


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Clinical diagnosis of Major Depressive Disorder 15 or more on MADRS-S Exclusion Criteria: Severe depression (more than 35 on MADRS-S or based on interview) Severe psychiatric condition (e.g. psychosis or bipolar disorder) Suicidal (measured in diagnostic interview) Changed medication during the last three months

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Internet-based Psychodynamic Therapy<br> | Behavioral: Internet-delivered psychodynamic therapy for depression<br>* This intervention contains 9 text-based self-help modules. These modules contain material inspired by psychoanalytic theory about identifying reoccurring patterns in life among other things. In addition to the self-help modules, 10-15 minutes of therapist contact is given every week. In total, the intervention will last for 10 weeks.<br>|
| Active Comparator: Internet-delivered therapist support<br> | Behavioral: Internet-delivered therapist support<br>* This intervention contains 1 text-based self-help module, which is mainly based on information on depression. In addition to this text, the participants in this group gets 10-15 minutes of therapist contact every week. In the conversation with the therapist, the participant informs the therapist about the activities during the week. This intervention is considered to be a form of support. In total, the intervention will last for 10 weeks.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Beck Depression Inventory (BDI) |  | Two weeks before the treatment starts | 
| Beck Depression Inventory (BDI) |  | At treatment start (0 weeks) | 
| Beck Depression Inventory (BDI) |  | At treatment termination (10 weeks) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Beck Anxiety Inventory (BAI) |  | Two weeks before the treatment starts | 
| Beck Anxiety Inventory (BAI) |  | At treatment termination (10 weeks) | 
| Montgomery Åsberg Depression Rating Scale Self-report (MADRS-S) |  | Two weeks before treatment starts | 
| Montgomery Åsberg Depression Rating Scale Self-report (MADRS-S) |  | At treatment termination (10 weeks) | 
| Quality of Life Inventory (QOLI) |  | Two weeks before treatment starts | 
| Quality of Life Inventory (QOLI) |  | At treatment termination (10 weeks) | 
| Patient Health Questionnaire 9 (PHQ-9) |  | Two weeks before treatment starts | 
| Patient Health Questionnaire 9 (PHQ-9) |  | At treatment termination (10 weeks) | 
| Generalised Anxiety Disorder Assessment 7 (GAD-7) |  | Two weeks before treatment starts | 
| Generalised Anxiety Disorder Assessment 7 (GAD-7) |  | At treatment termination (10 weeks) |