Prospective Analysis of Eosinophilic Esophagitis in Patients Presenting With Dysphagia

Study Overview
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Brief Summary
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This is a prospective descriptive cross sectional study to determine the percentage of patients presenting with dysphagia who are found to have eosinophilic esophagitis (EoE) and to establish which presenting factors warrant esophageal biopsies. We hypothesize that a greater than expected percentage of patients who are biopsies will have histologic changes consistent with EE.

Detailed Description
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All patients presenting with dysphagia who do not already carry a previous diagnosis for their dysphagia will be asked to enroll. If patients have undergone previous work up for dysphagia such as manometry, 24-hour probe, or barium swallow they can still participate in this study. Informed consent will take place prior to enrollment. After patients present with dysphagia they will fill-out a questionnaire regarding their dysphagia symptoms. An EGD with biopsies will then be performed. Biopsies will be taken from 4 quadrants in the proximal and distal esophagus. The distal esophagus biopsies will be taken 5 cm proximal to the Z-line. Proximal biopsies will be taken anywhere proximal to 30 cm from the incisors.

Official Title
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Prospective Analysis of Eosinophilic Esophagitis in Patients Presenting With Dysphagia

Conditions
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Esophagitis

Intervention / Treatment
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* Procedure: EGD with biopsies


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients aged 18-90 presenting with dysphagia or food impaction Ability to undergo esophagogastroduodenoscopy and biopsies No significant cardiopulmonary disease, or other contraindication to EGD Exclusion Criteria: Contradiction to EGD and/or biopsies such as Boerhaave's syndrome, or history or bleeding disorder or elevated INR Inability to provide informed consent Esophageal varices

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| I<br>All subjects presenting in with dysphagia will be in this cohort. | Procedure: EGD with biopsies<br>* All subjects presenting with dysphagia will undergo an EGD with distal and proximal biopsies of the esophagus.<br>* Other names: Upper endoscopy;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To assess the percentage of patients who present with dysphagia who have EE by histologic criteria |  | December 2010 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To assess the demographics of the EE patients with dysphagia |  | December 2010 | 
| To measure the frequency, severity, and time course of dysphagia in patients with EE |  | December 2010 | 
| To assess percentage of EE patients with recurrent, versus acute dysphagia |  | December 2010 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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dysphagia, eosinophilic esophagitis