Addressing Origins of the Opioid Epidemic by Improving Prescribing for Opioid-Naive Patients

Study Overview
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Brief Summary
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Risk of long-term opioid dependence increases with initial opioid dose/duration, but despite recent Centers for Disease Control and Prevention (CDC)-endorsed minimum doses for initial opioid prescription, primary care providers are likely to overprescribe. In this quality improvement project, primary care departments at Weill Cornell and the Institute for Family Health (federally qualified health center in New York City) will implement an unobtrusive nudge in their electronic prescribing software to promote the CDC-endorsed low doses for all opioids. In the evaluation, we will employ a quasi-experimental design with rigorous interrupted time series analysis methods to assess the effect of the nudge on prescribing rates. The analysis will be performed at the provider level, with deidentified physician data and a limited data set (fully deidentified except for date of prescription) of patient-level data.

Detailed Description
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The two participating institutions, WCMC (Weill Cornell Medical College) and IFH (Institute for Family Health), intend to redesign the e-prescribing interface to create a minor nudge to encourage prescribers to prescribe the minimum dose set by the 2016 CDC guideline for opioid-naive patients in 2018. The change to the e-prescribing system is that after a prescriber chooses the drug they wish to prescribe, the minimum recommended dosage from the CDC guidelines will be displayed. The prescriber can choose to change the dosage by overwriting in the field box. The changes to the prescriber system will be implemented at two Weill Cornell clinical organizations: Weill Cornell Internal Medicine Associates (WCIMA) and Weill Cornell Medical Associates (CMA), and at all locations at our collaborating institution IFH (Institute for Family Health). Weill Cornell and IFH will provide data for the analysis, which will be conducted by the co-investigators on this protocol. The project will assess data pre- and post- implementation to study prescribing patterns.

Official Title
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Addressing Origins of the Opioid Epidemic by Improving Prescribing for Opioid-Naive Patients

Conditions
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Opioid Use, Opioid-Related Disorders, Opioid Abuse, Prescription Drug Abuse and Dependency

Intervention / Treatment
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* Other: Default Prescribing Change


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Prescriber - practices internal medicine at WCMC OR family practice at IFH and has prescribed opioids since 11/1/2015 Exclusion Criteria: Prescriber - has not written any opioid prescriptions during the study period

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 89 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Interventional Model Description: This is a interrupted time series study model with one study group.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Default Prescribing Change<br>In the e-prescribing system, the default opioid dosage/duration is changed to the minimum recommended dosage from the CDC guidelines for short acting opioids. | Other: Default Prescribing Change<br>* In the e-prescribing system, the default opioid dosage/duration is changed to the minimum recommended dosage from the CDC guidelines for short acting opioids.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in the proportion of opioid prescriptions for opioid-naïve patients that comply with CDC recommendations before and after the intervention | Change in the proportion of opioid prescriptions for opioid-naïve patients that comply with CDC recommendations before and after the intervention | Two years prior to and six months after implementation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in the average days of supply of opioids for opioid naive patients | Change in the average days of supply of opioids for opioid naive patients | Two years prior to and six months after implementation |