The Attenuating Effect of Soluble Fiber Consumption on Postprandial Glycemia in Humans

Study Overview
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Brief Summary
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The main objective of the current study is to investigate whether consumption of soluble fibers (isomaltodextrin [IMD], partially digestible maltodextrin) and RS4 starch will lower postprandial glycemia as well as postprandial insulin in human subjects with relatively high fasting blood glucose, when consumed with a specific amount of digestible carbohydrate (rice porridge). The primary outcome of the study is the effect of fibers on postprandial blood glucose, whereas the secondary outcome will be its effect on postprandial blood insulin.

Official Title
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The Attenuating Effect of Soluble Fiber Consumption on Postprandial Glycemia in Humans

Conditions
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Postprandial Hyperglycemia, Type2 Diabetes, Blood Sugar; High

Intervention / Treatment
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* Other: Control
* Other: Isomaltodextrin Low Dose
* Other: Isomaltodextrin High Dose
* Other: GPC partially digestible maltodextrin
* Other: Resistant Starch Type 4


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Body mass index (18.5 kg/m² ≤ BMI ≤ 29.9 kg/m²) No history of abnormal glucose metabolism No ongoing use of drugs affecting blood glucose levels Fasting blood glucose between 90-110 mg/dL Low dietary fiber intake (less than 15 g per day) Exclusion Criteria: Diabetic individuals Individuals with history of gastrointestinal disease Pregnant or nursing women

Ages Eligible for Study
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Minimum Age: 22 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Control<br> | Other: Control<br>* 300 g rice porridge + 150 ml drinking water<br>|
| Experimental: Isomaltodextrin Low Dose<br> | Other: Isomaltodextrin Low Dose<br>* 300 g rice porridge + (5 g IMD in 150 ml drinking water)<br>|
| Experimental: Isomaltodextrin High Dose<br> | Other: Isomaltodextrin High Dose<br>* 300 g rice porridge + (10 g IMD in 150 ml drinking water)<br>|
| Experimental: GPC partially digestible maltodextrin<br> | Other: GPC partially digestible maltodextrin<br>* 300 g rice porridge + (15 g GPC fiber in 150 ml drinking water)<br>|
| Experimental: Resistant Starch Type 4<br> | Other: Resistant Starch Type 4<br>* 300 g rice porridge + (15 g RS4 starch in 150 ml drinking water)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postprandial glycemic response | Blood glucose will be measured, (AUC) | Acute study: [3 hours of measurement after consumption of test food] | 
| Postprandial glycemic response | Blood glucose will be measured, (C max) | Acute study: [3 hours of measurement after consumption of test food] | 
| Postprandial glycemic response | Blood glucose will be measured, (t max) | Acute study: [3 hours of measurement after consumption of test food] | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postprandial insulin response | Blood insulin will be measured, (AUC) | Acute study: [3 hours of measurement after consumption of test food] | 
| Postprandial insulin response | Blood insulin will be measured, (C max) | Acute study: [3 hours of measurement after consumption of test food] | 
| Postprandial insulin response | Blood insulin will be measured, (t max) | Acute study: [3 hours of measurement after consumption of test food] |