Description and Modeling of Swallowing Disorders After a Stroke

Study Overview
=================
Brief Summary
-----------------
The oropharyngeal junction participates in 3 interpenetrating functions: Swallowing, Breathing and Speech. In the context of ischemic or hemorrhagic stroke, these are altered, isolated or associated manner, causing major disorders and representing a source of handicap for patients. Understanding the swallowing mechanisms is therefore a major challenge to guide the rehabilitation and improve the initial and long-term prognosis of patients with stroke. The main objective of this study is to describe and modeling, thanks to a clinical, physiological and radiological knowledge base, swallowing, speech and breathing, in patients with stroke and in healthy subjects.

Conditions
-----------------
Stroke, Swallowing Disorders

Intervention / Treatment
-----------------
* Other: Neurological evaluation
* Other: Laryngological evaluation
* Other: MRI evaluation
* Other: Breathing investigation
* Other: MRI and articulatory investigation
* Other: Postural investigation
* Other: Voice and soundscape investigation


Participation Criteria
=================
Eligibility Criteria
-----------------
For patients after stroke Inclusion Criteria: First stroke confirmed by MRI < 15 days No severe leukoaraiosis Swallowing disorders identified (GUSS scale < 20) Neurological deficit identified (NIHSS scale <15) Patient able to cooperate for investigations Informed consent signed Exclusion Criteria: Cerebral hemorrhage History of neurological disease that can lead to swallowing disorders History of laryngological disease such as previous surgery or radiation neck Tracheotomy Vigilance disorders Pregnant, parturient or nursing woman Protected adult Simultaneous participation in another study Non registered to the French social security system For healthy subjects Inclusion Criteria : Age between 18 and 40 years old French native speaker Normal hearing with or without corrective No oral or written language disorders No neurological or psychiatric disorders Informed consent signed Exclusion Criteria MRI contraindication Pregnant, parturient or nursing woman Simultaneous participation in another study Non registered to the French social security system

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Stroke population<br>Patient with stroke will be explored during their acute phase and in 6 months of diagnosis. | Other: Neurological evaluation<br> <br> Other: Laryngological evaluation<br> <br> Other: MRI evaluation<br> <br> Other: Breathing investigation<br> <br> Other: Postural investigation<br> <br> Other: Voice and soundscape investigation<br> <br> |
| Healthy population<br>Healthy subjects will be explored in Grenoble in research laboratory | Other: Breathing investigation<br> <br> Other: MRI and articulatory investigation<br> <br> Other: Postural investigation<br> <br> Other: Voice and soundscape investigation<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of Clinical severity score | NIHSS scale | At inclusion and 6 months after diagnosis | 
| Change of swallowing disorder | Test : GUgging Swallowing Screen | Within 15 days after diagnosis and 6 months after diagnosis | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of aphasia disorder | Questionnaire : Aphasia rapid test | Within 15 days after diagnosis and 6 months after diagnosis | 
| Change of state of depression and anxiety | Questionnaire : anxiety and depression scale | Within 15 days after diagnosis and 6 months after diagnosis | 
| Change of behavioural attention | Questionnaire : Catherine Bergego scale | Within 15 days after diagnosis and 6 months after diagnosis |