The 90% Effective Flow of High Flow Nasal Oxygenation (HFNO) During Sedated Bronchoscopy

Study Overview
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Brief Summary
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Patients undergoing sedated bronchoscopy were randomized into six groups (10 Liters/minute [L/min], 20 L/min, 30 L/min, 40 L/min, 50 L/min, 60 L/min). The primary outcome was the incidence of hypoxemia.

Detailed Description
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It's a double-blind, randomized trial. The patients'demographic information, such as sex, weight, height, smoking status, present illness and history of past illness, were collected. After successful peripheral intravenous access, all patients, before sedation, received 20 min nebulization with lidocaine via a nebuliser facemask. The basic oxygen saturation, heart rate, and blood pressure of the patients were recorded by the investigators.Patients in the HFNO group received humidified oxygen at different rates via a high-flow nasal cannula (AIRVO2, New Zealand). After sedation with propofol and sufentanil, continuous electrocardiography and pulse oximetry were recorded, and the blood pressure of the patients was monitored throughout the procedure. . After bronchoscopy, patients were transferred to the post anesthesia care unit (PACU) if their vital signs were stable.

Official Title
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The 90% Effective Flow of High Flow Nasal Oxygenation During Deeply Sedated Bronchoscopy

Conditions
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Hypoxia

Intervention / Treatment
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* Device: high flow nasal cannula


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: (1) undergoing sedated bronchoscopy (2) 18 to 70 years of age; (3) American Society of Anaesthesiologists (ASA) class: I-III Exclusion Criteria: (1) severe cardiac disease, including aortic stenosis, mitral stenosis, hemodynamic instability caused by severe arrhythmia, and acute myocardial infarction or cardiac surgery within the last 6 months; (2) severe hypoxemia (SpO2 < 90% without oxygen supply on admission), caused by interstitial lung disease, end-stage chronic obstructive pulmonary disease (COPD) or other diseases; (3) upper respiratory tract infection or lung infection; (4) refusal to participate in this study.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Group 1<br>10 L/min of oxygen flow | Device: high flow nasal cannula<br>* The patients were randomized into 6 groups, each group received different flow of oxygen, to observe the incidence of hypoxemia between different groups.<br>|
| Experimental: Group 2<br>20 L/min of oxygen flow | Device: high flow nasal cannula<br>* The patients were randomized into 6 groups, each group received different flow of oxygen, to observe the incidence of hypoxemia between different groups.<br>|
| Experimental: Group 3<br>30 L/min of oxygen flow | Device: high flow nasal cannula<br>* The patients were randomized into 6 groups, each group received different flow of oxygen, to observe the incidence of hypoxemia between different groups.<br>|
| Experimental: Group 4<br>40 L/min of oxygen flow | Device: high flow nasal cannula<br>* The patients were randomized into 6 groups, each group received different flow of oxygen, to observe the incidence of hypoxemia between different groups.<br>|
| Experimental: Group 5<br>50 L/min of oxygen flow | Device: high flow nasal cannula<br>* The patients were randomized into 6 groups, each group received different flow of oxygen, to observe the incidence of hypoxemia between different groups.<br>|
| Experimental: Group 6<br>60 L/min of oxygen flow | Device: high flow nasal cannula<br>* The patients were randomized into 6 groups, each group received different flow of oxygen, to observe the incidence of hypoxemia between different groups.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the incidence of hypoxemia | hypoxemia was defined as SpO2 < 90% | during bronchoscopy | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| jaw thrust maneuver | percentage of jaw thrust maneuver | during bronchoscopy | 
| increase of flow rate | percentage of increase of flow rate | during bronchoscopy | 
| bag-mask ventilation | percentage of bag-mask ventilation | during bronchoscopy | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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high flow nasal oxygenation, hypoxemia, bronchoscopy, effective flow