Developing a New MRI Technique to Understand Changes in Brain Tumors After Treatment

Study Overview
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Brief Summary
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The purpose of this study is to develop and test a new magnetic resonance imaging (MRI) technique to see if it can be used to tell the difference between tumor growth from worsening of cancer and growth from the effects of treatment in participants who have brain tumors treated with radiation therapy called stereotactic radiosurgery (SRS).

Official Title
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Development of a Clinical CEST MR Fingerprinting Method for Treatment Response Assessment in Brain Metastases

Conditions
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Brain Metastases, Brain Metastases, Adult, Metastatic Brain Tumor, Metastatic Brain Cancer

Intervention / Treatment
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* Diagnostic Test: CEST-MRF


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy volunteers [for Study Aim 1 (SA1)] will be entered into the study if they meet the following criteria: Age ≥ 18 years Able to understand and give informed consent No known cancer diagnosis Patients [for Study Aim 3 (SA3)] will be entered into the study if they meet the following criteria: Age ≥ 18 years Able to understand and give informed consent At least one untreated brain metastasis > 1cm (e.g., an enhancing lesion in the brain of a patient with known systemic cancer determined likely to represent metastasis by neuroradiologist) Planned SRS treatment Exclusion Criteria: Healthy volunteers (SA1) and patients (SA2) exclusion criteria: Pregnant or breastfeeding women Pre-existing medical conditions, including the likelihood of developing seizures or claustrophobic reactions, and any greater than normal potential for cardiac arrest Age < 18 years

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Participants with Brain Metastases<br>Participants will have at least one untreated brain metastasis > 1cm | Diagnostic Test: CEST-MRF<br>* CEST-MRF enables accurate quantification of both proton exchange rates and volume fractions in a fraction of the time required by conventional pulse sequences will be developed and optimized.<br>* Other names: chemical exchange saturation transfer magnetic resonance fingerprinting method;|
| Healthy participants<br>Participants will have no known cancer diagnosis | Diagnostic Test: CEST-MRF<br>* CEST-MRF enables accurate quantification of both proton exchange rates and volume fractions in a fraction of the time required by conventional pulse sequences will be developed and optimized.<br>* Other names: chemical exchange saturation transfer magnetic resonance fingerprinting method;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of Rapid chemical exchange saturation transfer (CEST) imaging with magnetic resonance fingerprinting (MRF)/CEST-MRF parameters with and without motion | Develop a rapid and robust 3D CEST-MRF pulse sequence for clinical scanners using our preclinical CEST-MRF pulse sequence as a basis by evaluating the changes of the 6 CEST-MRF parameters with and without motion. These parameters include the water T1 and T2 relaxation (T1w,T2w), amide exchange rate (ksw) and volume fraction (fs) and the semi-solid exchange rate (kssw) and volume fraction (fss). | Up to 3 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Brain Metastases, Healthy Volunteers, metastatic brain tumor, metastatic brain cancer, Brain Metastases, Adult, MRI, untreated brain metastasis, CEST-MRF, chemical exchange saturation transfer magnetic resonance fingerprinting, 22-191, Memorial Sloan Kettering Cancer Center