Technical Development of up to 7T Magnetic Field Strength

Study Overview
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Brief Summary
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The objective of this study is to determine whether these new image acquisition strategies and techniques using of up to 7T can produce meaningful structural and physiological information that can serve to improve our understanding of various disease processes in the clinical setting. 200 Control volunteers will be scanned for approximately one hour, without contrast, on up to 7T MRI scanner. 200 Study Participants will be scanned using newly developed imaging software or hardware that conforms to applicable FDA standards and recommendations. The data (images) for the Control and Experimental Group will be de-identified by the scan technologist and downloaded to a workstation within the Radiology Department for offline processing. These images will be reviewed by a trained Radiologist after the subject has departed.

Official Title
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Technical Development of up to 7T Magnetic Field Strength

Conditions
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Healthy

Intervention / Treatment
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* Other: Control Volunteers
* Other: Clinical Volunteers


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy control volunteers, male and female, ages 18 and older (no history of chronic illness, concussion, malignancies, etc.) Exclusion Criteria: Contraindications with MRI (e.g. pacemakers or ferromagnetic material near vital structures, etc.)

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Control Volunteers<br>MRI on up to a 7T scanner without contrast. | Other: Control Volunteers<br>* MRI on up to a 7T scanner without contrast.<br>|
| Experimental: Clinical Patients<br>MRI on up to a 7T scanner without contrast.+ 10 minutes of research development imaging added onto their clinical MRI scans. | Other: Clinical Volunteers<br>* One-hour MRI on up to a 7T scanner without contrast + 10 minutes of research development imaging using radio frequency (RF) coils<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in signal to noise ratio using statistical analysis |  | 25 minutes | 
| Change in spatial resolution using statistical analysis |  | 25 minutes | 
| Change in Temporal Resolution using statistical analysis |  | 25 minutes | 
| Change in Image Contrast using statistical analysis |  | 25 Minutes | 
| Change in image homogeneity using statistical analysis |  | 25 minutes | 
| Change in artifact reduction using statistical analysis |  | 25 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Magnetic Resonance Imaging (MRI)