The Effect of a Peat and Apple Extract on Muscle ATP and Exercise Performance

Study Overview
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Brief Summary
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A study to test the hypothesis that a combined peat and apple extract will increase blood and muscle ATP, which will increase cycling performance

Official Title
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The Effect of a Peat and Apple Extract on Muscle ATP and Exercise Performance

Conditions
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Caffeine and Endurance Performance

Intervention / Treatment
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* Dietary Supplement: ElevATP supplement
* Dietary Supplement: Placebo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 18 - 40 Healthy Recreationally active (i.e. Participants will be deemed as too trained if they are defined as participating in structured resistance exercise 3 or more times per week for >6 months or participating in structured endurance exercise for >6h per week for >6 months. Participants will be defined as too sedentary if they do not exceed the governments guidelines of 150 / 75 min per week of light / heavy exercise.) Exclusion Criteria: Allergy to Lidocaine Any diagnosed metabolic health condition Pregnant Non-habitual caffeine intake Smoker Diagnosed Cardiovascular disease Beta-Blockers Recent history of musculoskeletal injury

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: ElevATP supplement<br> | Dietary Supplement: ElevATP supplement<br>* ElevATP supplement containing apple and ancient peat extract<br>|
| Placebo Comparator: Maltodextrin placebo<br> | Dietary Supplement: Placebo<br>* Maltodextrin placebo<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Muscle ATP concentration | Concentration of ATP in skeletal muscle tissue (mmol/kg dry weight) | 4 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Total work performed during exercise | Work performed during glycogen depleting exercise on a cycle ergometer (J) | 2 hours | 
| Blood ATP concentration | Concentration of ATP in blood (mmol/L) | 4 hours | 
| Substrate oxidation | Substrate oxidation over 1 h steady state cycle (g/min) | 1 hour | 
| Blood glucose concentration | Concentration of glucose in blood (mmol/L) | 4 hours | 
| Blood lactate concentration | Concentration of lactate in blood (mmol/L) | 4 hours | 
| Muscle glycogen | Muscle glycogen concentration in skeletal muscle tissue (mmol/kg dry weight) | 4 hours | 
| Muscle ADP concentration | Concentration of muscle metabolites | 4 hours (mmol/kg dry weight) | 
| Muscle ATP concentration | Concentration of muscle metabolites | 4 hours (mmol/kg dry weight) | 
| Muscle creatine concentration | Concentration of muscle metabolites | 4 hours (mmol/kg dry weight) | 
| Muscle phosphocreatine concentration | Concentration of muscle metabolites | 4 hours (mmol/kg dry weight) |