May Noninvasive Mechanical Ventilation (NIV) and/or Continuous Positive Airway Pressure (CPAP) Increase the Bronchoalveolar Lavage (BAL) Salvage in Patients With Pulmonary Diseases?

Study Overview
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Brief Summary
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The objective of our project is to find procedures and/or parameters to predict the diagnostic recovery (≥ 60% of the administered fluid volume) of bronchoalveolar lavage (BAL) fluid before bronchoscopy and to assess the impact of using non-invasive mechanical ventilation (NMV) or continuous positive airway pressure (CPAP) to achieve diagnostic recovery in patients with chronic obstructive pulmonary disease (COPD) and interstinal lungs disease for whom BAL performed during ordinary bronchoscopy turns out to be non-diagnostic.

Official Title
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May Noninvasive Mechanical Ventilation (NIV) and/or Continuous Positive Airway Pressure (CPAP) Increase the Bronchoalveolar Lavage (BAL) Salvage in Patients With Pulmonary Diseases?

Conditions
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Chronic Obstructive Pulmonary Disease, Interstitial Lung Disease

Intervention / Treatment
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* Procedure: BAL + PAP


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with diagnosed stable COPD (Stages 1-3) - experimental group; Patients with interstitial lung disease - experimental group Former and current smokers with normal lung function - potential control group 1; Never-smokers with normal lung ventilation - potential control group 2. Exclusion Criteria: No written, informed consent to participate in the research project. Severe respiratory failure (SaO2 < 90%) The patient qualified for home oxygen treatment or home mechanical ventilation Severe heart failure (NYHA class IV) COPD mMRC IV Myocardial infarction in the last two weeks or unstable angina Severe, particularly ventricular arrhythmias Platelet count < 20,000/ul INR > 2 or APPT > 36 sec Very severe obstruction: forced expiratory volume in 1 second (FEV1) < 30% of predicted.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 100 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: BAL + NIV<br>Qualification for a specific type of ventilation (NIV or CPAP) will be carried out in a randomized manner by a specially created online platform. The procedure will be performed subsequently in the same segment of the opposite lung. Once the test is finished, the volume of BAL fluid that has been recovered will be measured. | Procedure: BAL + PAP<br>* May noninvasive mechanical ventilation (NIV) and/or continuous positive airway pressure (CPAP) increase the bronchoalveolar lavage (BAL) salvage in patients with pulmonary diseases?<br>|
| Experimental: BAL + CPAP<br>Qualification for a specific type of ventilation (NIV or CPAP) will be carried out in a randomized manner by a specially created online platform. The procedure will be performed subsequently in the same segment of the opposite lung. Once the test is finished, the volume of BAL fluid that has been recovered will be measured. | Procedure: BAL + PAP<br>* May noninvasive mechanical ventilation (NIV) and/or continuous positive airway pressure (CPAP) increase the bronchoalveolar lavage (BAL) salvage in patients with pulmonary diseases?<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| May noninvasive mechanical ventilation (NIV) and/or continuous positive airway pressure (CPAP) increase the bronchoalveolar lavage (BAL) salvage in patients with pulmonary diseases? | Comparison of fluid recovery with BAL with and without NIV connection | 3 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Bronchoalveolar Lavage, Noninvasive Mechanical Ventilation, Continuous Positive Airway Pressure, Bronchoscopy