Changes of Serum Orphanin FQ in Patients With Coronary Heart Disease in Different Courses of Diabetes Mellitus

Study Overview
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Brief Summary
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To explore the severity of diabetic patients with coronary heart disease and the change of serum orphanin FQ content in different diabetic courses

Detailed Description
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Methods: A retrospective case-control study was conducted. The control group was a patient who underwent coronary angiography at the same time and was definitely diagnosed as coronary heart disease but not diabetes. The study group was coronary heart disease complicated with diabetes, which was divided into group A (≤5 years), group B (5-10 years) and group C (10-20 years) according to the course of diabetes. (1) Review the electronic medical records and record the general information of the selected patients: age, sex, history of hypertension, history of myocardial infarction, family history of coronary heart disease, smoking history, chronic kidney disease; ② laboratory findings: HbA1C (glycosylated hemoglobin), SBP (systolic blood pressure), DBP (diastolic blood pressure), total cholesterol, HDL, LDL, triglyceride, BMI, creatinine and glomerular passing rate (EGFR); ③ Drug use: oral hypoglycemic agents, insulin, aspirin, statins, hypertension drugs, ACEI or ARB, β-blockers, CCB and diuretics. (ii) Taking coronary angiography as the gold standard, the grading index of severity of coronary heart disease was made, and the severity of coronary heart disease was evaluated by Gensini score.

Official Title
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Study on the Changes of Serum Orphanin FQ in Patients With Diabetes Mellitus and Coronary Heart Disease in Different Courses

Conditions
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Type2 Diabetes

Intervention / Treatment
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* Procedure: Coronary angiography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: The main discharge diagnosis is T2DM；; Age > 18 years old; No acute complications of diabetes; The previous diagnosis was coronary heart disease Exclusion Criteria: T1DM patients; EGFR < 60 ml/min/1.73 m or proteinuria (or both); Patients with history of acute cardiovascular events; Familial hypercholesterolemia or other hereditary lipid metabolism diseases; anti-HIV patients; Patients with serious mental health problems; Patients receiving drugs that can lead to dyslipidemia, such as antipsychotics, corticosteroids, or immunosuppressants; Patients with systemic inflammatory diseases, such as systemic lupus erythematosus; Pet-name ruby is quitting smoking and severe obesity (BMI>40).

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| control group<br>Coronary heart disease population: after coronary angiography, Gensini score was used to evaluate the severity of coronary artery occlusion, and then compared with the population of type 2 diabetes complicated with coronary heart disease | Procedure: Coronary angiography<br>* Coronary angiography was performed in patients with coronary heart disease complicated with type 2 diabetes mellitus<br>|
| experimental group (course of disease <5 years)<br>Type 2 diabetes complicated with coronary heart disease (course of disease 5-10 years).Retrospective examination of patients' data, recording patients' laboratory tests and drug use, taking blood to measure orphanin, and evaluating the severity of coronary artery occlusion with Gensini score. | Procedure: Coronary angiography<br>* Coronary angiography was performed in patients with coronary heart disease complicated with type 2 diabetes mellitus<br>|
| experimental group(course of disease 5-10 years)<br>Type 2 diabetes complicated with coronary heart disease (course of disease 5-10 years). | Procedure: Coronary angiography<br>* Coronary angiography was performed in patients with coronary heart disease complicated with type 2 diabetes mellitus<br>|
| experimental group(course of disease10-20 years)<br>Type 2 diabetes complicated with coronary heart disease (course of disease 10 -20years).Finally, the data were obtained to evaluate the relationship between the course of diabetes and the severity of coronary heart disease, as well as the relationship between the course of diabetes and OFQ in patients' blood. | Procedure: Coronary angiography<br>* Coronary angiography was performed in patients with coronary heart disease complicated with type 2 diabetes mellitus<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Gensini score | Gensini score was used to evaluate the severity of coronary artery occlusion, and then compared with the population of type 2 diabetes complicated with coronary heart disease | 1 week | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Type 2 diabetes