Hypotension Prediction Index in Living Donor Liver Transplantation

Study Overview
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Brief Summary
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The Hypotension Prediction Index via the Edwards Hemosphere advanced monitoring system is monitored in living donor liver transplantation recipients. The Hypotension Prediction Index is analyzed to verify the performance in predicting hypotensive events.

Detailed Description
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Hypotensive events during surgery and anesthesia occur frequently and are associated with complications such as myocardial infarction, acute kidney injury, and increase in mortality. Therefore predicting and preventing hypotension can lead to better outcomes. The Hypotension Prediction Index is monitored with the Edwards Hemosphere advanced monitoring system in living donor liver transplantation recipients via the radial artery. The monitor is blinded so that the anesthesiologist cannot see the index, and the anesthesiologist manages the blood pressure according to the institution's anesthetic protocol for liver transplantation. After the surgery is done, the Hypotension Prediction Index is analyzed to see how well the index predicted actual hypotension that occured during the liver transplantation surgery. Receiver operating characteristic curves are drawn to show the performance of the Hypotension Prediction Index in liver transplantation.

Official Title
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Performance of the Hypotension Prediction Index in Living Donor Liver Transplantation

Conditions
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Living Donor Liver Transplantation, Hypotension

Intervention / Treatment
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* Device: Hypotension Prediction Index


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients scheduled for living donor liver transplantation aged 20 years and older Patients who understand the trial and have given informed consent Exclusion Criteria: Patients with arrhythmia or pacemaker

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Hypotension prediction index<br>prediction of hypotension events | Device: Hypotension Prediction Index<br>* Hypotension Prediction Index monitored via radial arterial line<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prediction of Hypotension 5 Minutes Before the Event | Receiver operating characteristic curve for the Hypotension Prediction Index, Comparison of the hypotensive event and the Hypotension Prediction Index 5 minutes before the event | During the surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prediction of Hypotension 10 Minutes Before the Event | Receiver operating characteristic curve for the Hypotension Prediction Index, Comparison of the hypotensive event and the Hypotension Prediction Index 10 minutes before the event | During the surgery | 
| Prediction of Hypotension 15 Minutes Before the Event | Receiver operating characteristic curve for the Hypotension Prediction Index, Comparison of the hypotensive event and the Hypotension Prediction Index 15 minutes before the event | During the surgery |