Fecal Immunochemical Test for Advanced Adenoma Detection in Colorectal Cancer Screening

Study Overview
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Brief Summary
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Early detecting and removing of colorectal advanced adenomas can reduce incidence of colorectal cancer. In order to reduce the incidence of colorectal cancer, improve the early diagnosis of colorectal cancer, the investigators conducted this study to explore diagnostic accuracy of fecal immunochemical test in colorectal cancer screening population.

Detailed Description
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Colorectal cancer accounts for approximately 10% of all annually diagnosed cancers and cancer-related deaths worldwide. With progress of developing countries, it is predicted that the incidence of colorectal cancer worldwide will increase to 2.5 million new cases in 2035. The majority of colorectal cancer is thought to arise from precancerous lesions through the adenoma-carcinoma pathway. Detecting and removing of colorectal advanced adenomas can reduce incidence of colorectal cancer. In order to reduce the incidence of colorectal cancer, improve the early diagnosis of colorectal cancer, the investigators conducted this study to explore diagnostic accuracy of fecal immunochemical test in colorectal cancer screening population.

Official Title
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Application of Fecal Immunochemical Test for Improving Advanced Adenoma Detection in Colorectal Cancer Screening

Conditions
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Colorectal Cancer, Colorectal Neoplasms, Colorectal Adenoma

Intervention / Treatment
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* Diagnostic Test: Fecal Immunochemical Test


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adults 50-75 years old Exclusion Criteria: People with history of intestinal surgery; People with history of colorectal cancer; People with history of inflammatory bowel disease, ischemic enteritis, vascular malformation of intestine or other disease resulting in intestinal tract bleeding; People with symptoms including visible rectal bleeding, hematuria, severe and acute diarrhea; Pregnancy, lactation or menstrual phase; Severe congestive heart failure or other sever disease cause cannot tolerate colonoscopy.

Ages Eligible for Study
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Minimum Age: 50 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Fecal Immunochemical Test<br>People in this group with positive fecal immunochemical test results were further examined by colonoscopy. | Diagnostic Test: Fecal Immunochemical Test<br>* Participants with positive fecal immunochemical test results were further examined by colonoscopy.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The efficacy of fecal immunochemical test to detect advanced adenoma | The detection rate and positive predictive value of fecal immunochemical test to detect advanced adenoma | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The efficacy of fecal immunochemical test to detect colorectal cancer | The detection rate and positive predictive value of fecal immunochemical test to detect colorectal cancer | 6 month | 
| The efficacy of fecal immunochemical test to detect colorectal neoplasms | The detection rate and positive predictive value of fecal immunochemical test to detect colorectal neoplasms | 6 month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Colorectal Adenoma, Occult Bleeding, Quantitative fecal immunochemical test