Intravascular Volume Assessment Using Ultrasonography in Pediatrics Renal Transplant: A Prospective Cohort Study

Study Overview
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Brief Summary
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This study is designed for volume assessment in pediatrics during major surgery using non-invasive tools as ultrasonography without the need of invasive techniques avoiding its complications and as a guide for fluid therapy needed for maintaining adequate hemodynamics

Detailed Description
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Intravascular volume assessment during surgery is important for maintaining adequate hemodynamics. Methods approved for volume assessment include the use of echocardiography to measure left ventricular end diastolic area (LVEDA), central venous pressure (CVP) and pulmonary artery diastolic pressure (PAD). LVEDA is considered the good predictor for volume status assessment. CVP and PAD are invasive can potentially subject the patient to complications. Recently study performed an ultrasound assessment of the internal jugular vein (IJV) as a useful means of volume status assessment intraoperative under general anesthesia. In the pediatric population, only few studies are carried out to assess the use of ultrasound for intravascular volume assessment. This study will evaluate use of Ultrasonography of IJV in volume assessment in pediatrics will undergo renal transplant surgery and correlate IJV diameter, cross sectional area to CVP and LVEDA.

Official Title
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Intravascular Volume Assessment Using Ultrasonography in Pediatrics Renal Transplant: A Prospective Cohort Study

Conditions
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Chronic Kidney Failure

Intervention / Treatment
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* Device: ultrasonography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Pediatric patients with end stage renal disease Weight between: 12 to 30 kg Exclusion Criteria: Infection at the site of CVP or generalized infection. IJV thrombosis

Ages Eligible for Study
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Minimum Age: 3 Years
Maximum Age: 12 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Sixteen patients having end stage renal disease<br>Intravascular volume assessment in 16 pediatric patients under going renal transplant surgery using ultrasonography, CVP and echocardiography | Device: ultrasonography<br>* Intravascular volume assessment using ultrasonography, CVP and echocardiography<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Internal jugular vein diameter, cross sectional area and left ventricular end-diastolic area | Correlation of IJV diameter and cross sectional area to LVEDA. | 3months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Internal jugular vein diameter, cross sectional area and central venous pressure | Correlation of IJV diameter and cross sectional area to CVP. | 3months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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volume assessment