Computational Assessment of Hand Motor Skills in Stroke Patients

Study Overview
=================
Brief Summary
-----------------
This is a two phase prospective observational study that aims to validate the use of a motion capture software (Leap Motion) to measure and quantify functional deficits of the hand in stroke patients using a standard battery of exercises. The objectives of this study are: To compare the differences between results of hand kinematic computational analysis in patients with ischemic stroke and healthy subjects. To analyze the relation between hand kinematic computational analysis and clinical scales usually performed to evalutate neurologic deficits in stroke patients. To analyze the relation between hand kinematic computational analysis and stroke lesion on brain MRI. To analyze changes between results of hand kinematic computational analysis in the acute phase of stroke and at three months, and its relation with evolution of neurological evaluation clinical scales, functional clinical scales and quality of life.

Official Title
-----------------
Computational Assessment of Hand Motor Skills in Stroke Patients

Conditions
-----------------
Ischemic Stroke

Intervention / Treatment
-----------------
* Device: Kinematic computational analysis of the hand (Leap Motion device)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Stroke patients: clinically stable, with hand functional deficit at the momment they consent to participate in the study. Signed consent to participate. Healthy subjects: similar age to stroke patients, without previous clinical history of stroke or any disease that could affect hand motor skills. Signed consent to participate. Exclusion Criteria: Aphasia or cognitive impairment, confusional syndrome or other conditions that could prevent comprehension and acomplishment of the task. Plegia or severe paresis of the hand that could prevent adecuate performance of the task. Previous stroke. Previous dependance. Previous diagnosis of any other neurologic disease or condition that could affect hand motricity. Life expectancy below three months.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Ischemic stroke patients with functional deficit of the hand<br> | Device: Kinematic computational analysis of the hand (Leap Motion device)<br>* Kinematic computational analysis exercises: Finger extension Wrist extension Finger separation Finger clamp<br>|
| Healthy subjects<br> | Device: Kinematic computational analysis of the hand (Leap Motion device)<br>* Kinematic computational analysis exercises: Finger extension Wrist extension Finger separation Finger clamp<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hand kinematic computational analysis | o compare the differences between results of hand kinematic computational analysis in patients with ischemic stroke and healthy subjects. | First month | 
| Relation between hand kinematic computational analysis and clinical scales | To analyze the relation between hand kinematic computational analysis and clinical scales usually performed to evalutate neurologic deficits in stroke patients. | First month | 
| Relation between hand kinematic computational analysis and stroke lesion on brain MRI. | To analyze the relation between hand kinematic computational analysis and stroke lesion on brain MRI. | First month | 
| Results of hand kinematic computational analysis in the acute phase of stroke and at three months, and its relation with evolution of neurological evaluation clinical scales, functional clinical scales and quality of life. | Changes between results of hand kinematic computational analysis in the acute phase of stroke and at three months, and its relation with evolution of neurological evaluation clinical scales, functional clinical scales and quality of life. | 1 month and three months |