Effects of Exercise in Patients With Coronary Artery Disease Aged 80 Years or Older

Study Overview
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Brief Summary
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The purpose of this study is to investigate the effects of exercise for patients with coronary artery disease (CAD) aged 80 years and older, with special reference to maximum aerobic capacity, muscle endurance, physical functioning, level of physical activity, health related quality of life, anxiety, depression and endothelial function, compared to a control group.

Official Title
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Effects of Exercise in Patients With Coronary Artery Disease Aged 80 Years or Older - a Randomized Controlled Trial

Conditions
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Coronary Artery Disease

Intervention / Treatment
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* Other: Exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Clinical diagnosis of acute coronary artery disease Aged 80 years or older Exclusion Criteria: Inability to understand or speak the Swedish language Serious physical or psychological disease interfering with participation in an exercise intervention Patients are already exercising three times or more/week

Ages Eligible for Study
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Minimum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Exercise<br>Individually prescribed hospital based exercise in group two times a week, home-based exercise once a week. The exercise intervention consists of interval based aerobic exercise on a bicycle ergometer 30 minutes with intensity level at 13-17 at Borg scale, resistance exercises and balance exercises | Other: Exercise<br>* Individually prescribed hospital based exercise in group two times a week, home-based exercise once a week. The exercise intervention consists of interval based aerobic exercise on a bicycle ergometer 30 minutes with intensity level at 13-17 at Borg scale, resistance exercises and balance exercises<br>|
| No Intervention: Control<br>Patients are asked to live as usual. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in maximum aerobic capacity | A maximum exercise test on an electronically braked cycle ergometer, with watts as marker of maximum aerobic capacity. | At baseline and after 4 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in level of physical activity | Level of physical activity will be measured by an accelerometer and an activity diary | At baseline and after 4 months | 
| Change in muscular endurance | Will be measured by three clinical endurance tests including unilateral isotonic heel lift, unilateral isotonic shoulder flexion, bilateral isometric shoulder abduction | At baseline and after 4 months | 
| Change in physical functioning | Including tests of balance: short physical performance battery, one leg standing, timed up and go, and the activities specific balance confidence scale. | At baseline and after 4 months | 
| Change in health related quality of life | measured by a self-rated health questionnaire | At baselline and after 4 months | 
| Change in anxiety and depression | measured by the hospital anxiety and depression scale | At baseline and after 4 months | 
| Change in endothelial function | Evaluated with non-invasive ultrasound | At baseline and after 4 months | 
| Change in transthoracic evaluation of resting coronary flow velocity |  | At baseline and after 4 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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coronary artery disease, elderly, exercise, exercise-based cardiac rehabilitation