linjc16/ctgov huggingface dataset:
Proteomics in Multiple Trauma to Identify Organ Failure

Study Overview
=================
Brief Summary
-----------------
To analyse differences in protein expression in multiple trauma patients for identification of potential biomarkers to predict organ dysfunction.

Detailed Description
-----------------
The aim of the present study in humans is to analyse differences in protein expression after multiple trauma in patients for identification of potential biomarkers to predict organ dysfunction.

Official Title
-----------------
Analysis of Predictive Parameters by Proteomics for Early Diagnosis of Organ Dysfunction in Multiple Trauma Patients - A Pilot Study

Conditions
-----------------
Multiple Trauma

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: older than 18 years multiple trauma patients ISS >16 Exclusion Criteria: children ISS <16

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No trauma<br>n=5 patients | |
| trauma without organ dysfunction<br>n=40 patients | |
| trauma with organ dysfunction<br>n=40 patients | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patients with disease or death vs. healthy | Starting at day O, then every 24 hours until day 20 | Day 0 until day 20 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
proteomics, multiple trauma, organ dysfunction
Self-administered Questionnaire to Evaluate Salt and Potassium Diet of Patients Followed in Nephrology

Study Overview
=================
Brief Summary
-----------------
The aim of the study is to create a self-questionnaire to evaluate sodium and potassium diet in chronic kidney disease patients. Questionnaires will be compared to 24h sodium and potassium urinary excretion (reference) A Bayesian network and a multiple regression will be used to select the most relevant items

Official Title
-----------------
Self-administered Questionnaire to Evaluate Salt and Potassium Diet of Patients Followed in Nephrology - UniverSEL Study

Conditions
-----------------
Nephropathy, Chronic Tubulointerstitial

Intervention / Treatment
-----------------
* Other: Salt and potassium Diet


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adult consulting in nephrology and having a 24h sodium urinary excretion routinely determined Consent informed agreement Exclusion Criteria: Do not want to participate

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Salt and potassium Diet|Self-administration questionnary to evaluate the salt and potassium consumption|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The aim of the study is to create a self-administered questionnaire to evaluate sodium and potassium consumption in chronic kidney disease patients. | comparison of answers to the self-questionnaire about salt and potassium diet with natriuresis and kaliuresis urinary excretion during 24 hours | at inclusion |
Acupuncture and Pain Processing

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to test the hypothesis that acupuncture will reduce Fibromyalgia pain, via alterations in the processing of pain in the central nervous system.

Detailed Description
-----------------
Patients and healthy controls will be enrolled in the study for a total of 6 weeks. This includes a screening and baseline visit, 8 acupuncture treatments (2 per week for 4 weeks), and a follow-up visit and treatment 1 week after completion of the study treatment sessions. To determine the effects of acupuncture on pain, patients and healthy controls will undergo psychophysical pain testing at four points throughout the study: Baseline (appointment 1), post-treatment 1 (appointment2), post treatment 8 (appointment 9), and at the final follow-up session (1 week from last treatment - appointment 10).Participants will also fill out a brief report on pain, sleep, and functioning on a palm pilot. This is expected to take less than 2 minutes per day and will occur throughout the 6 week study period.

Official Title
-----------------
Acupuncture and Pain Processing

Conditions
-----------------
Fibromyalgia

Intervention / Treatment
-----------------
* Procedure: Acupuncture


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age 18-50 Fibromyalgia patient OR healthy control No current opioid use Patients: must have had Fibromyalgia for 6 months or longer Exclusion Criteria: Inflammatory disorder (lupus, rheumatoid arthritis) Current untreated depression Active infection Healthy controls: pain disorder or major medical condition that in the discretion of the investigator interfere with the validity of the study Heart disease or use of a cardiac pacemaker

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Acupuncture<br> | Procedure: Acupuncture<br>* Treatment given twice per week for 4 weeks<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain rating to Temporal Summation and Diffuse Noxious Inhibitory Control (DNIC) as measured by a visual analogue scale |  | Measured at last study acupuncture session (6 weeks post enrollment) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Fibromyalgia Impact Questionnaire |  | Change from first to last study treatment session (6 weeks) | 
| Change in Brief Pain Inventory |  | Change from first to last treatment session (6 weeks) |
The Improvement in Uroflow and Postvoid Residual Urine After Urethral Meatotomy in Children With Meatal Stenosis

Study Overview
=================
Brief Summary
-----------------
The improvement in uroflow and postvoid residual urine in children after urethral meatotomy for meatal stenosis. The hypothesis is that there is an improvement in both parameters, thus justifying the procedure.

Detailed Description
-----------------
Urethral meatal stenosis is a known complication of circumcision occuring in up to 3% of newborns undergoing circumcision. It is customary to perform a meatotomy in order to prevent bladder outlet obstruction, although bladder outlet obstruction has never been proven and improvement has only been proved in a single, small, retrospective study. Our intention is to evaluate the improvement in objective parameters (uroflow and postvoid residual urine) after urethral meatotomy by measuring these parameter before the procedure, one month after the procedure and one year after the procedure. Symptoms assessment will also be performed.

Official Title
-----------------
The Improvement in Uroflow and Postvoid Residual Urine After Urethral Meatotomy in Children With Meatal Stenosis

Conditions
-----------------
Urethral Meatal Stenosis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Toilet trained children Before puberty No other urologic disease that might affect the measurements Primary (first) repair Exclusion Criteria: Children unable to urinate on command Children that have started their sexual puberty Children with other urologic disease that might affect the study measurements Recurrent stenosis after previous repair

Ages Eligible for Study
-----------------
Minimum Age: 2 Years
Maximum Age: 12 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Meatotomy<br>Toilet trained children scheduled for urethral meatotomy for the treatment of urethral meatal stenosis. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Improved maximal urine flow |  | one month and one year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Improved (reduced) postvoid residual urine |  | One month and one year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Meatal stenosis, Meatotomy, Uroflow, Postvoid residual
The Effects of Cordyceps Sinensis and Lingzhi on Cardiovascular Fitness and Cognitive Function

Study Overview
=================
Brief Summary
-----------------
Cordyceps Sinensis (CS) and Lingzhi extracts have been used in Chinese Medicine for many years for treatment of a variety of conditions. The aim of this study is to evaluate the effects of oral ingestion of CS and Lingzhi extracts of a period of 28 days on cardiopulmonary fitness and cognitive functioning in young, healthy physical education students.

Conditions
-----------------
Physical Fitness, Executive Function

Intervention / Treatment
-----------------
* Dietary Supplement: Cordyceps Sinensis (CS) and Lingzhi
* Dietary Supplement: Tea and Flour


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Physical education students Exclusion Criteria: All others

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: CS and Lingzhi<br>CS liquid (each dosage is a bottle of liquid containing 30 ml: comprising 75% of CS, 6% Lingzhi, 6% shitake, 5% bamboo shoot, 2% honey, 0.1% potassium sorbet and 5.9% pure water) and Lingzhi capsule (each capsule contains 620mg of: 52.42% Lingzhi, 28.23% CS, and 19.35% soy gel ) ; one quarter bottle of CS to be ingested twice a day, and the Lingzhi capsule to be taken once a day, both for a period of 28 days. | Dietary Supplement: Cordyceps Sinensis (CS) and Lingzhi<br> <br> |
| Placebo Comparator: Placebo<br>Liquid tea ingested twice a day and flour-filled capsules ingested once a day over a period of 28 days | Dietary Supplement: Tea and Flour<br>* Placebo<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Improvement in Cardiopulmonary Fitness after Ingestion of CS and Lingzhi Extracts | Before and after 28-day ingestion of CS and Lingzhi extracts, subjects will undergo a graded exercise test on a treadmill and results will be compared. | 28 days |
Rate Control in Atrial Fibrillation

Study Overview
=================
Brief Summary
-----------------
This study will evaluate the efficacy of metoprolol tartrate compared to carvedilol on heart rate control in patients with atrial fibrillation and a rapid ventricular rate.

Official Title
-----------------
Rate Control in Atrial Fibrillation: A Randomized, Double-Blind, Crossover Comparison of Carvedilol and Metoprolol Tartrate

Conditions
-----------------
Atrial Fibrillation

Intervention / Treatment
-----------------
* Drug: Carvedilol
* Drug: Metoprolol tartrate


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Permanent atrial fibrillation Baseline ventricular rate (prior to treatment) > 110 bpm Exclusion Criteria: History of accessory tract re-entry tachycardia Ejection fraction < 35% or history of NYHA Class III/IV stage C/D heart failure Acute coronary syndrome, percutaneous coronary intervention, or cardiac surgery in the past 2 months Child-Pugh class B or C hepatic dysfunction Uncontrolled hypertension Thyroid disease Intolerance to beta-blockers History of lung disease resulting in hospitalization in the past year

Ages Eligible for Study
-----------------
Minimum Age: 19 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Carvedilol<br>carvedilol BID for 2 weeks | Drug: Carvedilol<br> <br> * Other names: Coreg;|
| Experimental: Metoprolol tartrate<br>Metoprolol tartrate BID for 2 weeks | Drug: Metoprolol tartrate<br> <br> * Other names: Lopressor;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Resting heart rate | Resting heart rate less than 80 bpm | 2 weeks |
A Registry Study on Biomarkers of Pulmonary Embolism

Study Overview
=================
Brief Summary
-----------------
The purpose of the study is to evaluate the value of biomarkers in the diagnosis and risk stratification of patients with suspected pulmonary embolism.

Detailed Description
-----------------
Management of patients with acute pulmonary embolism is a serious problem. The rapid and accurate diagnosis and risk stratification of these patients is an important unmet clinical need. The aim of the study is to evaluate the value of biomarkers, alone or in combination, in the diagnosis and risk stratification of patients with suspected pulmonary embolism presenting to the emergency department.

Official Title
-----------------
Evaluation of Performances of Biomarkers in Pulmonary Embolism

Conditions
-----------------
Pulmonary Embolism

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patient aged ≥ 18 years that presents to an emergency department With suspected PE defined as new onset of or worsening of shortness of breath or chest pain Exclusion Criteria: Hemodynamic instability Life expectancy less than 3 months First symptoms 15 day or more before inclusion Inability to the follow-up visits Therapeutic anticoagulation for any indication

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group with PE<br>The criteria for confirmation of PE are: PE on spiral computed tomography (CT) proximal deep vein thrombosis on ultrasound (US) thromboembolic events objectively confirmed during the follow up | |
| Group without PE<br>The criteria for exclusion of PE are: low or moderate clinical probability and D-dimer ELISA <0.50 µg/mL or <10xage in patients older than 50 years and negative follow up low and moderate clinical probability and negative CT and negative follow up high clinical probability and negative CT, US and follow up. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Area under the ROC curve of biomarkers for the diagnosis of PE | The ROC curve will be built, the area under the curve will be calculated with its confidence interval. | 2 years | 
| PE related death | Number of PE related death | 7 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Symptomatic recurrent venous thromboembolic events | Number of symptomatic recurrent venous thromboembolic event | 2 years |
The Application of Invivo Microscopy Imaging in the Early Diagnosis of Cervical Cancer

Study Overview
=================
Brief Summary
-----------------
This study intends to carry out a prospective, randomized controlled trial to research and development a new invivo microscopy based on the technology which is combined with high-definition microscopy and colposcopy，so as to diagnose cervical lesion directly and non-invasively by observing cervical tissues and cells, which makes it possible to diagnose cervical cancer without wounds.

Official Title
-----------------
The Application of Invivo Microscopy Imaging in the Early Diagnosis of Cervical Cancer

Conditions
-----------------
Cervical Cancer, Cervical Precancer

Intervention / Treatment
-----------------
* Procedure: invivo microscopy group
* Procedure: normal group


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: cervical cytologic test result is HSIL persistent infection with high-risk HPV cervical pathological diagnosis is LSIL or HSIL Exclusion Criteria: acute infection of lower genital tract the wound in lower genital tract active bleeding in lower genital tract

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: invivo microscopy group<br>patients receive invivo micro-colposcopy examination and do not have to receive the biopsies | Procedure: invivo microscopy group<br>* patients receive invivo micro-colposcopy examination<br>|
| Other: normal group<br>patients receive normal colposcopy examination and the biopsy specimens are sent for pathological HE staining and analysis | Procedure: normal group<br>* patients receive normal colposcopy examination and the biopsy specimens are sent for pathological HE staining and analysis<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| diagnostic accuracy rate |  | 1 day (time of the examination) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| image accordance rate |  | 1 day (time of the examination) | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
invivo microscopy, colposcopy, cervical precancer and cancer
Treatment of Malignant Strictures in Esophagus and Gastroesophageal Junction With Covered or Partially Covered Stent.

Study Overview
=================
Brief Summary
-----------------
Self expandable stent (SEMS) constitutes the main palliative treatment in advanced esophageal cancer. The palliative effect of SEMS is immediate when it comes to relief of dysphagia. The duration of this effect is however questionable. The design of SEMS can be of importance since the device can dislodge and as a consequence of that dysphagia recur. The hypothesis has therefore been formulated that a partially covered SEMS is associated with less tendency to dislocate as compared to those SEMS, recently developed, which are covered through their entire length.

Official Title
-----------------
The Importance of Stent Design

Conditions
-----------------
Esophageal Cancer, Cancer of Gastro Esophageal Junction, Palliative Treatment

Intervention / Treatment
-----------------
* Device: Partially covered SEMS
* Device: Fully covered SEMS


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Verified Squamous Cell Carcinoma or Adenocarcinoma of esophagus or Gastro Esophageal Junction (GEJ) Age above 18 years. Dysphagia scoring grade two or worse Not amenable for curative treatment Informed consent to participate Exclusion Criteria: Concomitant cancer disease Inability to comply with study protocol Previous stent treatment Proximal location of the tumour in the esophagus. Need for more than one stent deployment.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Partially covered SEMS<br>Boston Scientific Ultraflex SEMS | Device: Partially covered SEMS<br> <br> |
| Experimental: Fully covered SEMS<br>Boston Scientific Wallflex Esophageal SEMS. | Device: Fully covered SEMS<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| SEMS dislocation in cm during first thirty days after stent insertion. |  | Thirty days from stent deployment. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Health Related Quality of Life (HRQOL) |  | Within three months of SEMS deployment. | 
| Need for reintervention |  | Within three months after SEMS | 
| Grade of dysphagia within three months of SEMS. |  | Three months after insertion. |