Validation of Combined PET-MR Quantitative Parameters for Cardiac Applications

Study Overview
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Brief Summary
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The purpose of this study is to understand how simultaneous PET/MR acquisition can provide novel qualitative and quantitative biomarkers to guide clinical intervention and predict prognosis of patients with cardiovascular disease.

Detailed Description
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To compare regional myocardial uptake of FDG on images obtained on a standard PET camera with the new PET/MR camera, in patients with coronary artery disease. To compare viability maps obtained with cardiac MR images and FDG-PET for delineation of myocardial infarct core and border zone, in patients with coronary artery disease. To correlate MRI myocardial strain with relative myocardial FDG uptake in patients with a previous myocardial infarction. To interrogate if simultaneous acquisition of cardiac PET and viability cardiac MR differ from acquisitions obtained independently, with special focus on attenuation correction methods To combined MRI scar map with FDG-PET uptake in patients with cardiac sarcoidosis and myocarditis. To correlate morphologic characteristics of atherosclerotic disease in the thoracic and abdominal aorta with FDG uptake and ferumoxytol enhancement, as a marker of inflammation. To evaluate cardiac strain and myocardial scar burden in obese patients with and without diabetes.

Official Title
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Validation of Combined PET-MR Quantitative Parameters for Cardiac Applications

Conditions
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Cardiac Disease

Intervention / Treatment
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* Device: PET-MRI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Subjects with ischemic and non-ischemic cardiac disease referred for cardiac PET for viability imaging. Exclusion Criteria: Contraindications for MRI, including cardiac pacemaker, claustrophobia, retained metallic foreign body, cochlear implant, Aneurysm clip in the brain, pregnancy and eGFR less than 45%.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Cardiac patients receiving PET/MR<br>PET-MRI with intravenous Gadolinium and FDG. The entire study will take approximately one hour. | Device: PET-MRI<br>* PET-MRI with intravenous Gadolinium and FDG. The entire study will take approximately one hour.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of Quality PET and PET/MR Images With Regional Myocardial Uptake of 18F-Fluorodeoxyglucose (FDG) in Participants Without Overt Diagnosis of Ischemic Coronary Artery Disease. | Visual analysis of collected image pairs. Evaluated by experienced imaging providers as yes or no. | 2 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Positron Emission Tomography-Magnetic Resonance Imaging, Cardiac Disease