Risk Factors and Impact of Anesthesia Techniques on Myocardial Infarction Following Transurethral Resection of the Prostate

Study Overview
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Brief Summary
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This study examined the risk factors and the influence of the type of anesthetic used during transurethral resection of the prostate (TURP) on subsequent incidence of myocardial infarction (MI).

Detailed Description
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This study utilized a population-based, nationwide dataset to evaluate the risk factors of MI for patients with benign prostate hypertrophy (BPH) who received TURP. Besides, The study also compared the different effects of general anesthesia (GA) and neuraxial anesthesia (NA) on the incidence of MI within 6 and 12 months after TURP.

Official Title
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Risk Factors and Impact of Anesthesia Techniques on Myocardial Infarction Following Transurethral Resection of the Prostate: a Nationwide Database Case Control Study

Conditions
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Anesthesia, Transurethral Resection of Prostate Syndrome, Myocardial Infarction

Intervention / Treatment
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* Other: general anesthesia or neuraxial anesthesia


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients receiving TURP surgery (1998-2012) Exclusion Criteria: Patients without anesthesia records Patients receiving both general and neuraxial anesthesia Mortality within 12 months of TURP
Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Without post-operative myocardial infarction<br>Patients without post-operative myocardial infarction after first admission for transurethral resection of the prostate | Other: general anesthesia or neuraxial anesthesia<br> <br> |
| With post-operative myocardial infarction<br>Patients with post-operative myocardial infarction after first admission for transurethral resection of the prostate | Other: general anesthesia or neuraxial anesthesia<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative myocardial infarction | Patients experienced myocardial infarction after transurethral resection of the prostate (TURP) | within 6 months after the first admission for TURP | 
| Postoperative myocardial infarction | Patients experienced myocardial infarction after transurethral resection of the prostate (TURP) | within 12 months after the first admission for TURP | 
| Patient's age (year-old) that developed post-TURP myocardial infarction | We analyze age distribution of patients with post-TURP myocardial infarction | within 6 months after the first admission for TURP | 
| Patient's age (year-old) that developed post-TURP myocardial infarction | We analyze age distribution of patients with post-TURP myocardial infarction | within 12 months after the first admission for TURP | 
| Number of patients with pre-operative diagnosed Diabetes Mellitus developing post-TURP myocardial infarction | We analyze pre-operative diagnosed Diabetes Mellitus rate in patients who had myocardial infarction after the surgery of TURP. | within 6 months after the first admission for TURP | 
| Number of patients with pre-operative diagnosed Diabetes Mellitus developing post-TURP myocardial infarction | We analyze pre-operative diagnosed Diabetes Mellitus rate in patients who had myocardial infarction after the surgery of TURP. | within 12 months after the first admission for TURP | 
| Number of patients with pre-operative diagnosed disorders of lipoid metabolism developing post-TURP myocardial infarction | We analyze pre-operative diagnosed disorders of lipoid metabolism rate in patients who had myocardial infarction after the surgery of TURP. | within 6 months after the first admission for TURP | 
| Number of patients with pre-operative diagnosed disorders of lipoid metabolism developing post-TURP myocardial infarction | We analyze pre-operative diagnosed disorders of lipoid metabolism rate in patients who had myocardial infarction after the surgery of TURP. | within 12 months after the first admission for TURP | 
| Number of patients with pre-operative diagnosed gout developing post-TURP myocardial infarction | We analyze pre-operative diagnosed gout rate in patients who had myocardial infarction after the surgery of TURP. | within 6 months after the first admission for TURP | 
| Number of patients with pre-operative diagnosed gout developing post-TURP myocardial infarction | We analyze pre-operative diagnosed gout rate in patients who had myocardial infarction after the surgery of TURP. | within 12 months after the first admission for TURP | 
| Number of patients with pre-operative diagnosed hypertension developing post-TURP myocardial infarction | We analyze pre-operative diagnosed hypertension rate in patients who had myocardial infarction after the surgery of TURP. | within 6 months after the first admission for TURP | 
| Number of patients with pre-operative diagnosed hypertension developing post-TURP myocardial infarction | We analyze pre-operative diagnosed hypertension rate in patients who had myocardial infarction after the surgery of TURP. | within 12 months after the first admission for TURP | 
| Number of patients with pre-operative diagnosed heart disease history developing post-TURP myocardial infarction | We analyze pre-operative diagnosed heart disease rate in patients who had myocardial infarction after the surgery of TURP. | within 6 months after the first admission for TURP | 
| Number of patients with pre-operative diagnosed heart disease history developing post-TURP myocardial infarction | We analyze pre-operative diagnosed heart disease rate in patients who had myocardial infarction after the surgery of TURP. | within 12 months after the first admission for TURP | 
| Number of patients with pre-operative diagnosed stroke history developing post-TURP myocardial infarction | We analyze pre-operative diagnosed stroke rate in patients who had myocardial infarction after the surgery of TURP. | within 6 months after the first admission for TURP | 
| Number of patients with pre-operative diagnosed stroke history developing post-TURP myocardial infarction | We analyze pre-operative diagnosed stroke rate in patients who had myocardial infarction after the surgery of TURP. | within 12 months after the first admission for TURP | 
| Number of patients with pre-operative diagnosed liver cirrhosis history developing post-TURP myocardial infarction | We analyze pre-operative diagnosed liver cirrhosis rate in patients who had myocardial infarction after the surgery of TURP. | within 6 months after the first admission for TURP | 
| Number of patients with pre-operative diagnosed liver cirrhosis history developing post-TURP myocardial infarction | We analyze pre-operative diagnosed liver cirrhosis rate in patients who had myocardial infarction after the surgery of TURP. | within 12 months after the first admission for TURP | 
| Number of patients with pre-operative diagnosed chronic obstructive pulmonary disease developing post-TURP myocardial infarction | We analyze pre-operative diagnosed chronic obstructive pulmonary disease rate in patients who had myocardial infarction after the surgery of TURP. | within 6 months after the first admission for TURP | 
| Number of patients with pre-operative diagnosed chronic obstructive pulmonary disease developing post-TURP myocardial infarction | We analyze pre-operative diagnosed chronic obstructive pulmonary disease rate in patients who had myocardial infarction after the surgery of TURP. | within 12 months after the first admission for TURP | 
| Number of patients with pre-operative diagnosed asthma developing post-TURP myocardial infarction | We analyze pre-operative diagnosed asthma rate in patients who had myocardial infarction after the surgery of TURP. | within 6 months after the first admission for TURP | 
| Number of patients with pre-operative diagnosed asthma developing post-TURP myocardial infarction | We analyze pre-operative diagnosed asthma rate in patients who had myocardial infarction after the surgery of TURP. | within 12 months after the first admission for TURP | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patients who had post-operative myocardial infarction after receiving general anesthesia for TURP | Number of patients who had post-operative myocardial infarction after receiving general anesthesia for TURP | within 6 months after the first admission for TURP | 
| Number of patients who had post-operative myocardial infarction after receiving neuraxial anesthesia for TURP | Number of patients who had post-operative myocardial infarction after receiving neuraxial anesthesia for TURP | within 6 months after the first admission for TURP | 
| Number of patients who did not have post-operative myocardial infarction after receiving general anesthesia for TURP | Number of patients who did not have post-operative myocardial infarction after receiving general anesthesia for TURP | within 12 months after the first admission for TURP | 
| Number of patients who did not have post-operative myocardial infarction after receiving neuraxial anesthesia for TURP | Number of patients who did not have post-operative myocardial infarction after receiving neuraxial anesthesia for TURP | within 12 months after the first admission for TURP |