Comparative Analysis of Serum Lipid Profiles in Patients With and Without Gallstones

Study Overview
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Brief Summary
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Gallbladder disease is one of the most common diseases of the gastrointestinal tract. Various studies have shown an association between gallstones and an alteration in the serum lipids. The objective of this study will be to compare serum lipid profile of gallstone patients with the controls.

Detailed Description
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This prospective cross-sectional study will be conducted in the Surgical Department of the Services Institute of Medical Sciences. A total of 50 patients will beincluded in the study after screening through the inclusion criteria. A control group of 50 inpatients with no personal or family history of gallstones will be also recruited for comparison. Results will be expressed as mean with standard deviation. Students t- test will be used to compare the data between the patients and the control groups (p<0.05 will be considered statistically significant). SPSS software, version 20 will be used for statistical analysis.

Official Title
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Comparative Analysis of Serum Lipid Profiles in Patients With and Without Gallstones: A Prospective Cross-Sectional Study

Conditions
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Gallstone, Dyslipidemias

Intervention / Treatment
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* Diagnostic Test: Serum lipid profile


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Male or female patients with the gall stone disease Age from 20 to 70 years Gallstones were diagnosed through the ultrasound Exclusion Criteria: Patients with acalculous gallbladder disease on ultrasound, Patients with terminal ileal resection, Patients with hemolytic diseases (hereditary spherocytosis, sickle cell anemia on history and CBC film), Patients with liver cirrhosis (on abdominal ultrasound) and Patients on antihyperlipidemic drugs

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| case group<br>patients presenting with gallstone disease | Diagnostic Test: Serum lipid profile<br>* Blood samples drawn from the patients and controls will be analyzed for serum cholesterol, serum triglycerides, serum LDLs and serum HDL levels. All the results will be recorded on a performa<br>|
| control group<br>inpatients with no history of gallstones | Diagnostic Test: Serum lipid profile<br>* Blood samples drawn from the patients and controls will be analyzed for serum cholesterol, serum triglycerides, serum LDLs and serum HDL levels. All the results will be recorded on a performa<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| serum cholesterol levels | serum cholesterol levels of patients and case group will be compared with Students t- test was (p<0.05 will be considered statistically significant) | 1 week | 
| serum triglyceride levels | serum triglyceride levels of gallstone patients and control group will be compared via student t-test (p<0.05 was considered statistically significant) | 1 week | 
| serum HDL levels | serum HDL levels of patients and contoled will be compared with student t-test (p<0.05 was considered statistically significant) | 1 week | 
| serum LDL leves | serum LDL leves of patients and control will be compared through student t-test (p<0.05 was considered statistically significant) | 1 week |