Comparison of Changes of ONSD Between Groups of Laparoscopic Surgery With and Without Epidural Saline Injection

Study Overview
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Brief Summary
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This study targets patients undergoing laparoscopic gastric cancer surgery. The investigators would like to compare two factors that influence intracranial pressure through optic nerve sheath diameter measurement. First factor is intraperitoneal pressure. Second factor is epidural pressure. The investigators divided the patients into three groups. Group A is patients with laparoscopic gastric surgery who received epidural injection through an thoracic epidural catheter. Group B is patients with laparoscopic gastric surgery who don't received epidural injection through an thoracic epidural catheter. Group C is patients with open gastric surgery.

Official Title
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Comparison of Changes of ONSD Between Groups of Laparoscopic Surgery With and Without Epidural Saline Injection

Conditions
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Optic Nerve Sheath Diameter, Pneumoperitoneum, Epidural

Intervention / Treatment
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* Procedure: Epidural injection through thoracic epidural catheter
* Procedure: Without epidural injection


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Gastric surgery due to cancer Exclusion Criteria: Coagulopathy Infection Previous history of thoracic spine surgery Ophthalmic diseases History of increased Intracranial Pressure

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Laparoscopic gastric surgery with Epidural injection<br>Patients with laparoscopic gastric surgery who received epidural injection through an thoracic epidural catheter. | Procedure: Epidural injection through thoracic epidural catheter<br>* The investigators inject drugs through a catheter inserted into the thoracic epidural space to control pain after surgery in patients undergoing gastric surgery by laparoscopy.<br>|
| Experimental: Laparoscopic gastric surgery without Epidural injection<br>Patients with laparoscopic gastric surgery who don't received epidural injection through an thoracic epidural catheter. | Procedure: Without epidural injection<br>* The investigators don't epidural injection to find out the effect of only inter-abdominal pressure on intracranial pressure.<br>|
| No Intervention: Open gastric surgery<br>Patients with open gastric surgery. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| T0 : Optic nerve sheath diameter | The investigator measures Optic nerve sheath diameter by ultrasonography. | 10 minutes after anesthesia induction | 
| T1 : Optic nerve sheath diameter | The investigator measures Optic nerve sheath diameter. | 10min after entering the laparoscope | 
| T2 : Optic nerve sheath diameter | The investigator measures Optic nerve sheath diameter. | 1hour after entering the laparoscope | 
| T3 : Optic nerve sheath diameter | The investigator measures Optic nerve sheath diameter. | 10min after the laparoscopy comes out | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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ONSD, pneumoperitoneum, epidural