Inspiratory Muscle Training in Patients With Interstitial Lung Disease

Study Overview
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Brief Summary
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The aim of this study is to evaluate the effects of inspiratory muscle training program in inspiratory muscle endurance, breathlessness, inspiratory muscle strength, functional capacity and quality of life in patients with interstitial lung disease. Patients are evaluated before the inspiratory muscle training and after 8 weeks of training.

Detailed Description
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Inspiratory Muscle Training has been described as an effective intervention and contribute to the improvement of inspiratory muscle function and breathlessness in patients with chronic lung disease. The aim of this study is to evaluate, the effects of inspiratory muscle endurance, breathlessness, inspiratory muscle strength, functional capacity and quality of life in patients with interstitial lung disease. It is a quasi-experimental study. Patients with interstitial lung disease are recruited from interstitial disease ambulatory. In each session patients performs two times 30 breaths with a minute rest between them. The load is set according with 50% of actual PImax, the Borg score should be between 4 and 6, otherwise the load will decrease (if Borg more than 6) or increase (if Borg less than 4). New PImax is measured weekly and the new load is defined following the same protocol for 8 weeks. Patients are evaluated before the inspiratory muscle training and after 8 weeks of training.

Official Title
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Effects of Inspiratory Muscle Training in Inspiratory Muscle Endurance, Breathlessness, Inspiratory Muscle Strength, Functional Capacity and Quality of Life in Patients With Interstitial Lung Disease

Conditions
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Interstitial Fibrosis, Pulmonary Disease, Interstitial Lung Disease, Sarcoidosis, Idiopathic Pulmonary Fibrosis, Pneumonia, Interstitial

Intervention / Treatment
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* Other: Inspiratory muscle training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Clinical and radiological diagnosis of interstitial lung disease established by a pulmonologist; Absence of clinical exacerbations of the disease in the four weeks prior to the initial data collection; Present medical research council scale more than 2; Absence of a associated or self reported cardiac, orthopedic and psychiatric diseases, Not participating in pulmonary rehabilitation programs; Do not use supplemental oxygen therapy while resting. Exclusion Criteria: - Inability of the participant to understand or perform the procedures proposed during the evaluations and training program.

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Interventional Model Description: Quasi-experimental
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Inspiratory muscle training group<br>Group intervention: home-based interval inspiratory muscle training during 8 weeks, two sessions with two sets of 30 breaths with one minute rest between them. Load set is determinated weekly, aiming 50% of actual PImax and according to Borg Score. | Other: Inspiratory muscle training<br>* Inspiratory muscle training will be performed using the tapered flow-resistive loading trainer (POWERbreathe®).<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Inspiratory muscle endurance | Endurance time in seconds | At baseline and after 8 weeks of training | 
| Change in Breathlessness | Medical Research Council (1-5) | At baseline and after 8 weeks of training | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Inspiratory muscle strength | Maximal inspiratory pressure in cmH20 | At baseline and after 8 weeks of training | 
| Change in Functional capacity | Maximal distance in 6 minute walk test | At baseline and after 8 weeks of training | 
| Change in Quality of life | King's Brief Interstitial Lung Disease Questionnaire. It is a 15 questions questionnaire. Total score can go from 0 - 100, 100 is the better quality of life. | At baseline and after 8 weeks of training | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Inspiratory muscle training, Interstitial lung disease, Inspiratory muscle endurance, Breathless