Early Prone Position on Coronavirus Disease 2019 Pneumonia

Study Overview
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Brief Summary
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the purpose of this study to evaluate the effect of early awake PP (prone position)application on oxygenation and intubation requirement in patients with acute respiratory failure due to coronavirus disease 2019 pneumonia.

Detailed Description
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The first group (early prone position-EPP) created for our study was composed of patients who received PP at least 12 hours early (with the first 48 hours) with the oxygen support of the reservoir mask, and the second group (non-EPP ) patients who received oxygen with the reservoir mask but could not be applied early PP due to the patient's incompatibility or rejection. Conventional oxygen therapy applied to all patients was given with a reservoir mask, aiming at oxygen saturation 93% and above, at a flow rate of 6-15 L / min. Despite all the treatments, the patients who have a follow-up with a respiratory acidosis , oxygen saturation value below 93%, applied non invasive mechanical ventilation, in case of insufficient patient intubated and have invasive mechanical ventilation. In patients who had regression of glasgow coma scale during follow-up, orotracheal intubation was performed and invasive mechanical ventilation was performed.

Official Title
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The Effect of Early Prone Position on Prognosis in Acute Respiratory Failure Due to Coronavirus Disease 2019 Pneumonia

Conditions
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Coronavirus Infection, Acute Respiratory Failure

Intervention / Treatment
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* Behavioral: prone position


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients who developed acute respiratory failure due to coronavirus disease 2019 pneumonia received conventional oxygen therapy with reservoir mask oxygen at the stage of admission to the intensive care unit older than 18 years old Exclusion Criteria: patients with respiratory acidosis, partial oxygen pressure/fraction of inspired oxygen ratio below 150, Glasgow Coma Score (GKS) below 12 points, hemodynamic instability, primary pulmonary pathologies other than pneumonia (lung cancer, cardiopulmonary edema, carcinogen syndrome, etc.) patients who underwent non-invasive mechanical ventilation(NIMV) or intubated from admission to intensive care, those who underwent self prone position under 12 hours were not included in the study.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| EPP<br>patients who applied early awake prone position for treatment with conventional oxygen supply | Behavioral: prone position<br>* to lay in prone position at least 12 hour in a day at ICU<br>|
| non-EPP<br>patient who only get conventional oxygen therapy as respiratory supply | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| intensive care unit stay | the duration of icu stay day | up to 28 days | 
| short term mortality | mortality percent | up to 28 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| blood gases | partial oxygen pressure: mmhg , partial carbondiocsit pressure mmhg | up to 24 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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coronavirus disease 2019, prone position