Feasibility Study of Phase-contrast MRI for Flow in the External Carotid Branches Arteries

Study Overview
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Brief Summary
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The phase-contrast MRI offers the advantage to combine precisely vascular flow measurements data with morphological images. Even if the anatomy of the external carotid artery is well known, data obtained through Phase contrast MRI could permit to progress in several fields of cranio-maxillofacial surgery as for example arteriovenous malformations,radionecrosis, head and neck micro-reconstructive surgery. The aim of this study is to establish and develop Phase-contrast MRI sequences for vascular flow characterization branches of the external carotid artery in healthy patients and in pathological cases.

Official Title
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Feasibility Study of Phase-contrast MRI for Flow in the External Carotid Branches Arteries in Normal and Pathological Cases

Conditions
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Carotid Artery, External

Intervention / Treatment
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* Device: Magnetic Resonance Imaging (MRI),


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: group 1 : healthy volunteer group 2 : X-Ray treatment antecedent (at least 50 grays and older than one year) group 3 : antecedent of embolization of branches of external carotid artery group 4 : antecedent of muscular free flap surgery (older than one month) free and informed consent Exclusion Criteria: group 1 : facial pathology, antecedent of facial injury, antecedent of X-Ray treatment in head and neck localisation, antecedent of head and neck cancer group 2 : antecedent of surgery for head and neck cancer or for vascular disease group 3 : antecedent of surgery for head and neck cancer or for vascular disease ; antecedent of X-Ray treatment. group 4 : antecedent of surgery for head and neck cancer or for vascular disease ; antecedent of X-Ray treatment or embolization patient with guardianship or trusteeship MRI cons-indications pregnancy and lactation

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Healthy volunteers<br>Magnetic Resonance Imaging (MRI) | Device: Magnetic Resonance Imaging (MRI),<br>* Magnetic Resonance Imaging (MRI) of flow using phase contrast (PC) methods<br>|
| Experimental: Patients treated by radiotherapy<br>Magnetic Resonance Imaging (MRI) | Device: Magnetic Resonance Imaging (MRI),<br>* Magnetic Resonance Imaging (MRI) of flow using phase contrast (PC) methods<br>|
| Experimental: Patients treated by embolization<br>Magnetic Resonance Imaging (MRI) | Device: Magnetic Resonance Imaging (MRI),<br>* Magnetic Resonance Imaging (MRI) of flow using phase contrast (PC) methods<br>|
| Experimental: Patient operated on with free flap<br>Magnetic Resonance Imaging (MRI) | Device: Magnetic Resonance Imaging (MRI),<br>* Magnetic Resonance Imaging (MRI) of flow using phase contrast (PC) methods<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| measurability of flow 1 | flow data in the branches of external carotid artery in every 4 groups, characterized by measuring the maximum speed | 1 hour | 
| measurability of flow 2 | flow data in the branches of external carotid artery in every 4 groups, characterized by measuring the minimum speed | 1 hour | 
| measurability of flow 3 | flow data in the branches of external carotid artery in every 4 groups, characterized by measuring the average speed | 1 hour | 
| measurability of flow 4 | flow data in the branches of external carotid artery in every 4 groups, characterized by measuring the maximum flow rates | 1 hour | 
| measurability of flow 5 | flow data in the branches of external carotid artery in every 4 groups, characterized by measuring the minimal flow rates | 1 hour | 
| measurability of flow 6 | flow data in the branches of external carotid artery in every 4 groups, characterized by measuring the medium flow rates | 1 hour | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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External carotid artery, Facial artery, Lingual artery, Superior thyroid artery, Internal maxillary artery, Phase-contrast MRI, Rate of flow, Superficial temporal artery