Patients At Risk for Sensory Screening (HPARSS) to Enhance Sensory Deficit Screening in Childhood Cancer Survivors

Study Overview
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Brief Summary
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The overall goal of this study is to attempt to overcome the organizational barriers that impede prompt screening for at-risk sensory deficits in childhood cancer survivors (CCS). Using a cross sectional design study, collaborators in the Informatics Research branch of the Institute of Informatics at the Washington University School of Medicine will identify CCS at risk for sensory deficits based upon their therapy exposure to generate the highlighting patients at risk for sensory screening (HPARSS) document. The investigators will utilize the HPARSS that will link therapy related risks for sensory deficits to specific screening procedures prompting the primary oncology provider to implement screening, diagnostic testing, and therapy.

Official Title
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Highlighting Patients At Risk for Sensory Screening (HPARSS) to Enhance Sensory Deficit Screening in Childhood Cancer Survivors

Conditions
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Childhood Cancer

Intervention / Treatment
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* Other: Highlighting Patients at Risk for Sensory Screening (HPARSS)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with a diagnosis of pediatric cancer (diagnosis at <18 years of age) Treatment including chemotherapy and/or radiation therapy Completion of all cancer therapy for at least 6 months and less than 2 years Followed in the Division of Pediatric Hematology/Oncology Program at the Washington University School of Medicine Current age between 7 and 17 years of age (age where all of the screening tests are both valid and have been successfully performed by our group) English speaking Exclusion Criteria: Undergoing active cancer treatment Patient under the care of the Late Effects Program at St. Louis Children's Hospital Received previous diagnostic testing or rehabilitative therapy for a secondary deficit eligible for screening. Parents and/or patient illiteracy No contact with treatment team in the past two years In foster care or without a legal guardian

Ages Eligible for Study
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Minimum Age: 7 Years
Maximum Age: 17 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Health Services Research
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Patients: Highlighting Patients at Risk for Sensory Screening (HPARSS)<br>The primary oncology team will utilize the HPARSS to identify patients who are at risk for sensory deficits based on prior treatment. The HPARSS will constitute a file of that will contain eligible patients based upon their past treatment and their corresponding risk for a particular sensory deficit based upon that treatment. The patient and parent/guardian will be approached to participate in the study. Sensory deficit screening will be completed in the clinic and any screening results that indicate the need for referral for diagnostic testing or therapy will be scheduled by the primary treatment team staff. | Other: Highlighting Patients at Risk for Sensory Screening (HPARSS)<br>* Collaborators in the Informatics Research branch of the Institute of Informatics at the Washington University School of Medicine will identify CCS at risk for sensory deficits based upon their therapy exposure to generate the HPARSS document.<br>|
| No Intervention: Providers: Highlighting Patients at Risk for Sensory Screening (HPARSS)<br>-Providers will complete a survey regarding their views of the HPARSS. The Acceptability of Intervention Measure has 4 questions and the Feasibility of Intervention Measure has 4 questions. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percentage of patients with at risk for sensory deficits identified by HPARSS |  | Through completion of enrollment for all patients (estimated to be 9 months) | 
| Percentage of at risk patients who fail the assigned screening test |  | Through completion of enrollment for all patients (estimated to be 9 months) | 
| Percentage of patients in need of referral for screen test results who participate in formal diagnostic testing and/or treatment |  | Through 1 year after the completion of screening test for all participants (estimated to be 1 year and 9 months) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number and types of barriers to participation in formal diagnostic testing and therapy in CCS failing to engage in sensory screening |  | At approximately 2 months following the patient's screening | 
| Number and types of facilitators to participation in formal diagnostic testing and therapy in CCS failing to engage in sensory screening |  | At approximately 2 months following the patient's screening | 
| Acceptability of HPARSS as measured by the Acceptability of Intervention Measure (AIM) | -4 questions inquiring about the acceptability of HPARSS with answers ranging from completely disagree=1 to completely agree=5. The higher the score indicates higher acceptability of the HPARSS. | To be completed at the time of enrollment completion (approximately 9 months) | 
| Feasibility of intervention as measured by Feasibility of Intervention Measure (FIM) | -4 questions inquiring about the feasibility of HPARSS with answers ranging from completely disagree=1 to completely agree=5. The higher the score indicates higher feasibility of the HPARSS. | To be completed at the time of enrollment completion (approximately 9 months) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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childhood cancer survivors, electronic medical record, sensory deficit screening, hearing loss, peripheral neuropathy, vestibular, vision