Preemptive Analgesia for Primary Dysmenorrhoea

Study Overview
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Brief Summary
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Preemptive analgesia before the release of pain mediators

Detailed Description
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spasmodic dysmenorrhea is one of the most distressing symptoms in women. adolescents shows a usual absence from school . prostaglandin release is one of the most accepted theory responsible for spasmodic dysmenorrhea. Non steroidal anti inflammatory Drugs were proved to be one of the alternative medications for spasmodic dysmenorrhea. Getting the idea of what is called preemptive anesthesia by blocking the receptors before catching pain mediators the study participants will be divided randomly into 2 group group 1 receiving ttt 2 days before the anticipated menstruation and group 2 receiving ttt only during menstruation as analgesia

Official Title
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Preemptive Analgesia for Primary Dysmenorrhoea: a Randomized Controlled Trial

Conditions
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Primary Dysmenorrhea

Intervention / Treatment
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* Drug: preemptive mefenamic acid
* Drug: mefenamic acid


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: nulliparous ladies with regular menstrual cycle pattern those experienced history of dysmenorrhea (primary or spasmodic) patients able to sallow tables Exclusion Criteria: irregular cycles any associated local causes( pelvic infection, endometriosis, fibroid or others) patients with familial Mediterranean fever or other intermenstrual attacks of abdominal pain gastric or duodenal ulcers or gastritis other contraindications to non steroidal anti-inflammatory drugs patients with severe diminution of vision or color discrimination patients with any depressive or mood disorders patients receiving any hormonal treatment

Ages Eligible for Study
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Minimum Age: 15 Years
Maximum Age: 25 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: premenstruation group<br>preemptive mefenamic acid 500mg tablets every 8 hours starting 2 days before anticipated menstruation and during the first 2 days of the cycle | Drug: preemptive mefenamic acid<br>* preemptive analgesia before menstrual pain<br>* Other names: ponstan forte;|
| Experimental: menstruation group<br>mefenamic acid 500mg tablets every 8 hours during the first 2 days of the cycle | Drug: mefenamic acid<br>* mefenamic acid given only during menstruation<br>* Other names: ponstan forte;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change in the Degree of pain | severity of pain according to visual pain analog scale | 4 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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primary dysmenorrhea, preemptive analgesia