Prehospital Prediction of Large Anterior Vessel Occlusion

Study Overview
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Brief Summary
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For the clinical benefit of intravenous thrombolysis IVT or intra-arterial thrombectomy IAT time is the most crucial factor. Reducing the time between stroke onset en treatment is therefore a major goal. Since IAT is only suitable for stroke due to large anterior vessel occlusion LAVO which is only performed in specialized comprehensive stroke centers CSC, triage of LAVO-patients in the prehospital phase (i.e. in the ambulance) in order to directly allocate them to such a specialized CSC will save vital time (time=brain!). Several LAVO-prediction scales for clinical triage have been developed but most were tested in- hospital by experienced neurologists. Consequently, there is a great need for validation of these scales in the prehospital setting by Emergency Medical Services EMS personnel. Objective: to recalibrate, validate performance and assess feasibility of several existing LAVO-prediction scales in the prehospital phase (i.e. assessment by EMS personnel). Study design: multiregional, multicenter observational cohort study to investigate performance and feasibility of LAVO-prediction scales a. Study population: all patients potentially eligible for IVTIAT according to the protocol used by EMS personnel except for when younger than 18 years.

Detailed Description
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The study will be conducted in two EMS regions: Hollands Midden and Haaglanden. In addition, all hospitals in these regions that treat over 30 patients per year with IVT will participate, including at least 1 CSC with IAT-availability per region. These hospitals are: Leiden University Medical Center LUMC; Alrijne hospital (location Leiderdorp); Haaglanden Medical Center (HMC+); Haga hospital; LangeLand hospital (LLZ) and Reinier de Graaf hospital (RdGG). The observational design is pragmatic and reflects standard practice for acute stroke care. inclusion: All patients with suspected stroke potentially eligible for IVT/IAT as estimated by the on-site EMS nurse. A web based application is used that merely structures observations that are currently noted on transport charts. EMS personnel will have access to the web-based application via the iPad/tablet/smartphone/computer on which the EMS transport chart is already filled out as part of standard care. Or via their patient record as used in the ambulance. The application will consist of the following items: EMS transport number time of symptom onset probability of LAVO estimated by EMS nurse 9-12 questions to structure clinical observations made by the EMS nurse. The application will be straightforward and designed in close co-operation with EMS personnel. With the items acquired all prediction scales can be reconstructed. Data of the application will be retrieved retrospectively and coupled with retrospectively collected data from the participating hospitals by a trusted third party

Official Title
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Prediction of Large Anterior Vessel Occlusion: a Prospective Observational Study Comparing Prehospital Prediction Scales

Conditions
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Stroke, Acute

Intervention / Treatment
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* Diagnostic Test: pre hospital triage tool


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Acute stroke code activated by EMS personnel Exclusion Criteria: Age <18 years

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: pre hospital triage tool|EMS workers fill in an application containing 10-13 vclinical items|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| symptomatic Large Anterior Vessel Occlusion | TICI score | on admission | 
| Feasibility outcome | reconstruction rate of cuttoff and/or full scale | within first hour | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| final diagnosis | diagnosis after discharge and/or after three months. | Three months | 
| Endovascular therpay | EVT | within first 24 hours of admission | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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large vessel occlusion, Endovascular trombectomy, pre-hospital stroke triage