Predicting MRI Abnormalities With Longitudinal Data of the Whitehall II Substudy

Study Overview
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Brief Summary
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Follow-up study within the Whitehall II study, selecting 800 participants for further neuropsychological, clinical and imaging (MRI) examinations to examine brain structure and function in relation to age-related diseases and the modifiable and non-modifiable factors affecting resilience against and vulnerability to adverse brain changes.

Detailed Description
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A total of 6035 civil servants participated in the WHII Phase 11 clinical examination in 2012-2013. A random sample of 800 of these participants was included in a sub-study comprising an MRI brain scan, a detailed clinical and cognitive assessment, and collection of blood and buccal mucosal samples for the characterisation of immune function and associated measures. Data collection for this sub-study started in 2012 and was completed by in 2016. The participants, for whom social and health records have been collected since 1985, were between 60-85 years of age at the time the MRI study started. The pre-specified clinical and cognitive assessment protocols, the state-of-the-art MRI sequences and latest pipelines for analyses of this sub-study have been published and are attached to this application.

Official Title
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Predicting MRI Abnormalities With Longitudinal Data of the Whitehall II Substudy

Conditions
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Cognitive Impairment, Dementia, Affective Disorders

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Member of Whitehall II cohort attending at UCL for phase 11 Exclusion Criteria: Not suitable for MRI, travelling to Oxford, seriously physically ill
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Neuropsychological measure 1 | National Adult Reading Test (premorbid intellectual ability) | 2012-2016 | 
| Neuropsychological measure 2 | Montreal Cognitive Assessment (MoCA) | 2012-2016 | 
| Neuropsychological measure 3 | Rey Complex Figure copy and delayed recall (visual episodic memory) | 2012-2016 | 
| Neuropsychological measure 4 | Hopkins Verbal Learning Test Revised (verbal episodic memory) | 2012-2016 | 
| Neuropsychological measure 5 | CANTAB Simple and Choice Reaction Time (processing speed) | 2012-2016 | 
| Neuropsychological measure 6 | WAIS-R Digit Symbol Test (processing speed) | 2012-2016 | 
| Neuropsychological measure 7 | Trail Making Test A and B (processing speed/executive functioning) | 2012-2016 | 
| Neuropsychological measure 8 | WAIS-R Digit Span forward and backwards (executive functioning) | 2012-2016 | 
| Neuropsychological measure 9 | Graded Naming Test (semantic memory) | 2012-2016 | 
| MRI Measures 1 | Siemens 3T - T1-weighted scan (MPRAGE) using FSL FIRST, FAST, and Freesurfer Volume extractions | 2012-2016 | 
| MRI Measures 2 | Siemens 3T - T1-weighted scan (MPRAGE) using FSL GLM Voxel based analysis for grey matter density analysis | 2012-2016 | 
| MRI Measures 3 | Siemens 3T - T2-weighted scan, clinical and FSL (BIANCA)-based rating of white matter changes | 2012-2016 | 
| MRI Measures 4 | Siemens 3T Diffusion Tensor Images analyzed with Tract Based Spatial Statistics (TBSS) | 2012-2016 | 
| MRI Measures 5 | Siemens 3T rs-fMRI analyzed with Multivariate Exploratory Linear Optimized Decomposition into Independent Components: MELODIC) | 2012-2016 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Epidemiology, Magnetic resonance imaging, Diffusion tensor imaging, White matter, Functional MRI, Connectome, Resting state brain networks, Neuropsychology