Management of Spontaneous Ruptured Hepatocellular Carcinoma

Study Overview
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Brief Summary
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To investigate the best treatment for hepatocellular carcinoma rupture

Detailed Description
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To investigate the best treatment for hepatocellular carcinoma rupture, transcatheter arterial embolization or partial hepatectomy. Furthermore, to discuss the choice of emergency or staged hepatectomy.

Official Title
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Management of Spontaneous Ruptured Hepatocellular Carcinoma - Partial Hepatectomy and Prognosis: A Retrospective Study

Conditions
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Rupture, Spontaneous, Rupture Liver, Hepatocellular Carcinoma

Intervention / Treatment
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* Procedure: Partial hepatectomy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Being diagnosed as hepatocellular carcinoma with tumor rupture; with complete data and without loss of follow-up Exclusion Criteria: Without complete data; with loss of follow-up; not hepatocellular carcinoma based on pathological diagnosis

Ages Eligible for Study
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Minimum Age: 15 Years
Maximum Age: 76 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Partial hepatectomy|Partial hepatectomy was comprised of single or multiple liver resections aiming to excise all macroscopic tumors.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overall survival of all patients | Overall survival difference between the partial hepatectomy group and the non-surgical group | 5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative peritoneal dissemination | Postoperative peritoneal dissemination diagnosed by imaging examination | 5 years | 
| Recurrence-free survival of all patients | Recurrence-free survival difference between the partial hepatectomy group and the non-surgical group | 5 years | 
| Overall survival of partial hepatectomy patients | Overall survival difference between the emergency partial hepatectomy group and the staged partial hepatectomy group | 5 years | 
| Recurrence-free survival of partial hepatectomy patients | Recurrence-free survival difference between the emergency partial hepatectomy group and the staged partial hepatectomy group | 5 years | 
| Overall survival of staged partial hepatectomy patients | Overall survival difference between the staged early partial hepatectomy group and the staged late partial hepatectomy group | 5 years | 
| Recurrence-free of staged partial hepatectomy patients | Recurrence-free survival difference between the staged early partial hepatectomy group and the staged late partial hepatectomy group | 5 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Emergency, Partial hepatectomy, Staged, Peritoneal dissemination, Propensity score matching