The Effect of neutrophil-to Lymphocyte Ratio in Preeclampsia- Eclampsia

Study Overview
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Brief Summary
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Neutrophil/lymphocyte ratio (NLR) is a marker of systemic inflammation and endothelial dysfunction. In recent years, it has been reported that the individual components of the differential white cell count, specifically the neutrophil and lymphocyte counts,may have clinical utility in predicting diseases. An elevated NLR has been shown to be a prognostic indicator in various malignancies. İn the literature, many studies have been shown that NLR have predictive value in determining the prognosis of various diseases (cardiac or noncardiac diseases ). However, little is known about the predictive values of NLR in pregnancy complications. This study aimed to evaluate the potential predictive value of NLR in preeclampsia- eclampsia.

Detailed Description
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In recent years, have been reported that the individual components of the differential white cell count, specifically the neutrophil and lymphocyte counts, may have clinical utility in predicting diseases. An elevated NLR has been shown to be a prognostic indicator in various malignancies. İn the literatüre have been shown that NLR have predictive value in determining the prognosis of various diseases (cardiac or noncardiac diseases.However, little is known about the predictive values of NLR and PLR in gestational DM, preeclampsia and the other pregnancy complications. Retrospective data were collected for patients who was diagnosed with , preeclampsia- eclampsia, The NLR was defined as the absolute neutrophil count divided by the absolute lymphocyte count.

Official Title
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the Predictive Value of neutrophil-to Lymphocyte Ratio on Preeclampsia- Eclampsia

Conditions
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Preeclampsia, Eclampsia

Intervention / Treatment
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* Biological: high neutrophil to lymphocyte ratio
* Other: normal neutrophil-to Lymphocyte ratio


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: pregnant women who developing preeclampsia eclampsia at pregnancy Exclusion Criteria: Known chronically maternal disease multiple pregnancy older than 40 years old

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| normal pregnancy outcomes<br>do not expect poor pregnancy outcomes on normal patients | Biological: high neutrophil to lymphocyte ratio<br> <br> Other: normal neutrophil-to Lymphocyte ratio<br> <br> |
| adverse pregnancy outcome<br>high ratio of Neutrophil / lymphocyte ratio may predict preeclampsia eclampsia | Biological: high neutrophil to lymphocyte ratio<br> <br> Other: normal neutrophil-to Lymphocyte ratio<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the effect of neutrophil lymphocyte ratio in preeclampsia eclampsia | during 6 months ,the patients who was recorded with preeclampsi/eclampsia at our hospital ,first trimester whole blood count was taken and neutrophil lymphocyte ratio was calculated and recorded | up to 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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preeclampsia, eclampsia, prediction, neutrophil-to Lymphocyte ratio