linjc16/ctgov huggingface dataset:
Immunophenotyping of Acute b Cell Lymphoblstic Leukemia

Study Overview
=================
Brief Summary
-----------------
To study the immunophenotyping pattern of acute B lymphoblastic leukemia in south Egypt Cancer Institute iand its correlation with disease outcome

Detailed Description
-----------------
study the immunophenotyping pattern of acute B lymphoblastic leukemia in south Egypt Cancer Institute from 2009 -2019 and its correlation with disease outcome

Official Title
-----------------
Immunophenotyping of Acute b Cell Lymphoblastic Leukemia

Conditions
-----------------
Acute Leukemia

Intervention / Treatment
-----------------
* Other: stastical analysis


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: New cases admitted to SECI Who didn't receive treatment.Age above 1 years old. Exclusion Criteria: Cases who received treatment Patients below 1 years old.Patients diagnosed as AML or T-ALL

Ages Eligible for Study
-----------------
Minimum Age: 12 Months
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: stastical analysis|1-Clinical examination data-Complete Blood Count (CBC).Bone Marrow Aspiration (BMA)-Bone Marrow Biopsy (BMB). (if available)-Immunophenotyping results (IPT).Cytogenetic results|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| overall survival outcome | overall survival outcome | 10 years | 
| Disease-free survival outcome | Disease-free survival outcome | 10 years | 
| association of novel CD markers with old markers for assessment of disease outcome | association of novel CD markers with old markers for assessment of disease outcome | 10 years |
Preoperative Pulmonary Systolic Pressure and Outcome After Non-cardiac Surgery:Threshold Analysis

Study Overview
=================
Brief Summary
-----------------
The linear or nonlinear relationship of pulmonary systolic pressure and cardiovascular and kidney outcome after non-cardiac surgery is unknown. This study is to explore the relationship of the two and try to identify the possible threshold of pulmonary systolic pressure for major cardio-vascular events after non-cardiac surgery.

Detailed Description
-----------------
The linear or nonlinear relationship of pulmonary systolic pressure and cardiovascular and kidney outcome after non-cardiac surgery is unknown. This study is to explore the relationship of the two and try to identify the possible threshold of pulmonary systolic pressure for major cardio-vascular events after non-cardiac surgery. Patients with preoperative cardio-echogram under going non-cardiac surgery were collected. The postoperative major cardiovascular, cerebral and kidney events were also identified and collected. Other data including peri-operative information and surgeries and anesthesia data were gathered. Logistic regression models were built and selected. Independent risk factors relative to postoperative major cardiovascular and cerebral events were screened and identified. Odds ratio, relative risk and relative risk ratio of varies dichomitus cut points were calculated, trend breakpoint were identified, propensity score analysis were also done for causal inference.

Official Title
-----------------
Preoperative Pulmonary Systolic Pressure and Outcome After Non-Cardiac Surgery:Threshold Analysis

Conditions
-----------------
Pulmonary Hypertension

Intervention / Treatment
-----------------
* Other: NO intervention required


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: non-cardiac surgery patients with preoperative echocardiography records Exclusion Criteria: electronic records missing or peri-operative data missing

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: NO intervention required|NO intervention required|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| major adverse events | cardiac infarction, heart failure, cardiac death, stroke, acute kidney injury | 30 days postoperatively in hospital | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Pulmonary Hypertension, major cardiovascular event, non-cardiac surgery,threshold
Health Related Quality of Life and Cognitive Function Among Norwegian Dialysis Patients

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to assess health related quality of life and its predictors among chronic dialysis patients and to assess cognitive function using 3 different tests. (undergraduate medical student research project; not published)

Official Title
-----------------
Health Related Quality of Life and Cognitive Function Among Norwegian Dialysis Patients, a Cross-sectional Study

Conditions
-----------------
Chronic Kidney Failure, Renal Dialysis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Chronic kidney failure Active dialysis treatment Aged over 18 years Able to read and answer the quality of life questionaire Exclusion Criteria: -

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 105 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Glucose and Lipid Metabolism in Adolescents

Study Overview
=================
Brief Summary
-----------------
A 12 wk aerobic exercise program will reduce visceral, hepatic and intramyocellular fat accumulation and improve insulin sensitivity and glucose metabolism in obese sedentary Hispanic adolescents.

Detailed Description
-----------------
Lean and Obese post pubertal adolescents perform an aerobic exercise program 30 minx4/week at a heart rate corresponding to at least 70% of that obtained at VO2 peak. The exercise program is preceded and followed by a 7 d diet delivered by the metabolic research kitchen (identical on both study occasions); metabolic studies (identical on both study occasions) including 24h calorimetry, measurements of glucose and lipid metabolism and insulin sensitivity and secretion using compounds labelled with stable i.e. non radioactive isotopes and gas chromatography-mass spectrometry.Fat mass and lean body mass are measured by DXA and visceral/subcutaneous, hepatic and intramyocellular fat by MRI/MRS. Since we want to specifically determine the effects of exercise, there is no intent of weight loss. The subjects are weighed twice a week to assure weight stability.

Official Title
-----------------
Glucose and Lipid Metabolism in Adolescents

Conditions
-----------------
Exercise, Obesity, Insulin Sensitivity

Intervention / Treatment
-----------------
* Behavioral: Exercise


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy No medication Sedentary No first degree relative with diabetes, Hispanic BMI >30 or <25 kg/m2. Exclusion Criteria: Any medication including birth control pills Performing more than >45 min of moderate to light physical activity/week Chronic illness

Ages Eligible for Study
-----------------
Minimum Age: 13 Years
Maximum Age: 17 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Adolescents<br>Post pubertal, sedentary lean and obese Hispanic adolescents | Behavioral: Exercise<br>* 12 wk aerobic or/ resistance exercise program<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fat distribution, insulin sensitivity, glucose production, gluconeogenesis, glycogenolysis |  | In response to a 12 wk exercise program. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Lipolysis, blood lipids, adiponectin, leptin and CRP |  | In response to a 12 wk exercise program | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Exercise in obesity
Angiotensinogen Gene and Hypertension

Study Overview
=================
Brief Summary
-----------------
Genetic studies of hypertension, focusing on renin-angiotensin system genes and other interacting genes

Conditions
-----------------
Hypertension

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with hypertension Exclusion Criteria: Patients with hypertension and reluctant for the study

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Impact of Alarm Reduction on Delirium in ICU

Study Overview
=================
Brief Summary
-----------------
Delirium is an acute and fluctuating disturbance of consciousness and can occur in 80% of critically ill patients. Delirium is more frequent in mecanically ventilated patients and is associated with longer hospital stay, increased cognitive impairment and mortality. On the occasion of the change of the monitors in the ICU ward, allowing a total withdrawal of alarms in patients room, this study evaluates the prevalence of delirium before and after the alarm withdrawal. During the first period the patients will be monitored as usual, and during the second period patients will be monitored without alarms ringing in patients room. Delirium will be screened with a validated, clinical tool.

Official Title
-----------------
Impact of Alarm Reduction on Delirium in ICU

Conditions
-----------------
Delirium

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age>18 years, admission to ICU Exclusion Criteria: length of stay in ICU<24 hours, moribund patient, deafness, dementia, psychiatric pathology, delirium at admission, acute neurological pathology at admission (stroke, epilepsy, neuro-infection), hepatic encephalopathy, admission for cardiac arrest, admission for voluntary drug intoxication, pregnancy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| group before alarm withdrawal<br> | |
| groupe after alarm withdrawal<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| prevalence of delirium, according to a ICDSC score>3 | prevalence of delirium in each group | at the end on the ICU stay, an average of 6 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| prevalence of sub-syndromic delirium in each group, according to a ICDSC score<4 and absence of delirium |  | at the end on the ICU stay, an average of 6 days | 
| length of mecanical ventilation (days) |  | at the end on the ICU stay, an average of 6 days | 
| length of stay in ICU (days) |  | at the end on the ICU stay, an average of 6 days | 
| in patients presenting a delirium, duration of delirium (days) defined by the number of days with a ICDSC score>3 |  | at the end on the ICU stay, an average of 6 days |
Prospective Study of Dietary Factors, BMI, and Risk of Asthma in Children

Study Overview
=================
Brief Summary
-----------------
Asthma is a common illness among children in the United States. While there are many known causes of asthma, including tobacco smoke, pollen, dust, or other allergens, the exact cause of asthma in some individuals remains unknown. This study will examine the role that specific dietary factors and body mass index (BMI) play in the development of childhood asthma.

Detailed Description
-----------------
Asthma prevalence has steadily increased in the United States since the early 1980s, but the exact cause of this increase remains unknown. It is estimated that at least 8% of Americans have asthma. Although anti-inflammatory medications have proven effective for decreasing asthma exacerbations, there are few treatment options available to prevent the initial onset of the disease. Dietary factors and BMI may play a role in the development of asthma. Specifically, individuals who eat foods containing antioxidants (e.g., vitamin C, vitamin E, and carotenoids), n-3 polyunsaturated fatty acids (e.g., fish oils), and vitamin D may have a decreased risk of developing asthma, while individuals with higher BMI ratios may have an increased asthma risk. The purpose of this study is to evaluate the relationship among dietary factors, BMI, and the incidence of asthma among children. This study will enroll children participating in the Growing Up Today study and children of nurses who are participating in the Nurses Health Study II. Researchers will analyze participants' previously completed questionnaires on dietary intake, physical activity, height, weight, and the presence of physician-diagnosed asthma. All participants with physician-diagnosed asthma will receive an additional asthma questionnaire. A small portion of these participants will also have their medical records reviewed by study researchers, and mothers of these children will be asked to complete a questionnaire. Additionally, a questionnaire will be sent to and completed by children who do not have asthma and their mothers.

Official Title
-----------------
Prospective Study of Dietary Factors, BMI, and Risk of Asthma in Children

Conditions
-----------------
Asthma

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Children of women in the Nurses Health Study II (NHS2) Participated in the Growing Up Today study Exclusion Criteria: None

Ages Eligible for Study
-----------------
Minimum Age: 9 Years
Maximum Age: 14 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| incident asthma |  | childhood | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Diet, Body Mass Index, BMI
Zyvox (Linezolid) Special Investigation For Vancomycin-Resistant Enterococci (VRE)

Study Overview
=================
Brief Summary
-----------------
To collect the efficacy and safety information in subjects who have been treated with Zyvox (linezolid) for vancomycin resistance Enterococcus faecium infection for their appropriate use in daily practice.

Official Title
-----------------
Zyvox (Linezolid) Special Investigation For Vancomycin-Resistant Enterococci (VRE)(Regulatory Post Marketing Commitment Plan)

Conditions
-----------------
Vancomycin Resistance Enterococcus Faecium

Intervention / Treatment
-----------------
* Drug: Zyvox (linezolid)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Subject to whom Zyvox (linezolid) was administered. Infected subject with Vancomycin resistance Enterococcus faecium. Exclusion Criteria: Infected subject with MRSA and other organism.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Zyvox (linezolid)<br>Patients who have been treated with Zyvox (linezolid). | Drug: Zyvox (linezolid)<br>* Patients should be treated with Zyvox (linezolid) 600 mg every twelve hours.<br>* Other names: linezolid, Zyvox;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of Participants With Adverse Drug Reactions. | All observed or volunteered adverse events and the investigator's opinion of the causal relationship to the study treatment were reported as adverse events. Definition of adverse drug reaction was treatment related adverse events which were evaluated in company with the causal relationship to the investigational product. | Baseline to 8 weeks | 
| Number of Participants Categorized as Responders (Cure and Improved) to Zyvox (Linezolid) Treatment. | Clinical overall effectiveness was evaluated by investigators based on clinical symptoms, laboratory test and investigator judgement, at the end of observation period. Clinical rating (cure/improved/not cured/unable to evaluate) was carried out. Definition of cured was disappearance of clinical symptom and/or Laboratory test abnormality. Definition of improved was improvement in clinical symptoms and/or laboratory test abnormality. | Baseline to 8 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Adverse Drug Reactions Unlisted in Japanese Package Insert. | The adverse drug reactions that have not been included in Japanese package insert. | Baseline to 8 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
VRE, Japanese, Post Marketing Surveillance
Clinical Score Usefulness and EHR Integration

Study Overview
=================
Brief Summary
-----------------
The SOFA score is a severity of illness and prognostic score used in the ICU. It has also recently been adopted as part of the definition of sepsis. This study will prospectively evaluate the usability of automated SOFA scoring for ICU patients within an electronic patient monitoring dashboard. It will also assess for changes in physician ordering (volume and types of orders) after automatic scoring is implemented.

Official Title
-----------------
Evaluation of Clinical Score Usefulness and Feasibility of Integration Into Electronic Health Record Interfaces

Conditions
-----------------
Sepsis

Intervention / Treatment
-----------------
* Other: Automated SOFA scoring calculator


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients admitted to the medical intensive care unit within 2 months of automated SOFA scoring module activation. Exclusion Criteria: Refusal to allow medical records to be used for clinical research.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Prospective cohort<br>This group will include ICU patients for the two month period after the automated SOFA score has been activated within the electronic patient care dashboard. | Other: Automated SOFA scoring calculator<br>* Automated SOFA scoring will be activated within an existing electronic patient care dashboard for ICU patients.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| SOFA related laboratory order volume | The total number of SOFA related laboratory orders on all patients in the ICU during the intervention period | 2 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Module usability | Providers will be surveyed on the usability of the automated scoring module | 2 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Sepsis, SOFA score, Automated calculation
Evaluation of Esophageal Injuries in Corrosives in Assiut Governorate - Experimental Comparison Between Different Treatments

Study Overview
=================
Brief Summary
-----------------
Esophageal stricture is one of the most common sequelae of caustic injury. Up to 70% of patients with grade IIB and more than 90% of patients with grade III injury are likely to develop esophageal stricture. Stricture formation can be prevented by suppressing fibrosis and scar formation therefore; many agents are explored for treatment on various models in this subject.

Detailed Description
-----------------
In spite of the multiple efforts to educate the public, Caustic ingestion maintains its place as an important public health issue due to the availability of caustic agents and the loose regulatory control on its production. All the cases will be evaluated by detailed history and thorough physical examination and necessary investigations. Patient's sheet will include; name, age, sex, occupation, residence, type of administrated substance, route and mode of exposure, symptoms and sighs (pain , vomiting , diarrhea) and any received treatment.

Official Title
-----------------
Evaluation of Esophageal Injuries in Corrosives in Assiut Governorate - Experimental Comparison Between Different Treatments

Conditions
-----------------
Clinico-epidemiological Characteristics of Corrosive Patients Presenting at Assiut Governorate

Intervention / Treatment
-----------------
* Behavioral: development of complications or not


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: -1- All the cases with the primary diagnosis of acute caustic injury will be included in the study. 2- Willing and able to comply with the study procedures and provide written informed consent to participate in the study. Exclusion Criteria: 1- Caustic substance ingested patient with any chronic disease. 2- Patients with history of congenital esophageal stricture. 3- Unable to provide informed consent. 4- Unlikely to return at 8 weeks. 5- Ingestion of substances other than corrosive (co-ingestion).

Ages Eligible for Study
-----------------
Minimum Age: 6 Months
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| corrosive patients<br> | Behavioral: development of complications or not<br>* assessment of development of complications<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| fate of cases | development of esophageal stricture or not | 6 months |