linjc16/ctgov huggingface dataset:
Detection of Amplification of Her2 Fluorescent in Situ Hybridization (FISH) in Breast Tissue Sections

Study Overview
=================
Brief Summary
-----------------
The purpose of the study is the identification of amplification level in human breast tissue. The imaging system is intended for diagnostic use as an aid to the pathologist in the detection, counting and classification of Her2 FISH stained tissue samples.

Official Title
-----------------
Concordance Study for Amplification Detection of Her2 FISH in Breast Tissue Sections

Conditions
-----------------
Breast Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Well stained breast tissue slides with bright Her2 signals Exclusion Criteria: Very old slides that were already bleached

Ages Eligible for Study
-----------------
Minimum Age: 21 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Breast cancer<br>Slides containing breast cancer paraffin embedded tissue sections. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Her2, FISH, Breast cancer, Amplification
Using Rapid Cycle Trials to Increase Patient Engagement in the Community Health Worker Program in the Emergency Department

Study Overview
=================
Brief Summary
-----------------
This study is evaluating the effectiveness of the post-discharge program facilitated by the Community Health Worker program in the Emergency Department at NYU Langone Health Hospital - Brooklyn and testing different strategies to increase patient engagement in the program.

Official Title
-----------------
Using Rapid Cycle Trials to Increase Patient Engagement in the Community Health Worker Program in the Emergency Department at NYU Langone Health Hospital-Brooklyn

Conditions
-----------------
Patient Engagement; Community Health Workers

Intervention / Treatment
-----------------
* Other: Community Health Worker Assessment


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients who present for a visit at the Emergency Department at NYU Langone Brooklyn Hospital and who qualify for the Community Health Worker program assessment and enrollment. Exclusion Criteria: N/A
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No intervention<br>Patients in this arm will not be approached by community health workers during their visit to the Emergency Department. | |
| Community Health Worker Program<br>Participants in this group will be approached by a community health worker during their visit to the Emergency Department with the goal of enrolling them in a comprehensive post-discharge program. | Other: Community Health Worker Assessment<br>* Participants will be approached by a community health worker who will ask them to complete an assessment of needs and offer to enroll them in post-discharge services to help address the needs identified.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Service utilization | Number of services (emergency department visits, etc.) utilized by the patient. | 1 year | 
| Post-discharge program enrollment rate | Total number of patients who agree to enroll in the post-discharge program/total number of patients approached by community health workers. | 1 year |
Conventional Mechanical Ventilation and High Frequency Percussive Ventilation: Comparison of Their Effects on Alveolar Recruitment and Distension by CT-scan in Early ARDS Patients

Study Overview
=================
Brief Summary
-----------------
High frequency percussive ventilation (HFPV) is a high frequency ventilation mode in which high frequency pulses accumulate to generate a low frequency tidal volume at a controlled airway pressure. Previous studies have suggested a protective effect of HFPV on lung injury. The goal of our study is to compare, in early ARDS patients, the effects of conventional mechanical ventilation and of high frequency percussive ventilation on alveolar recruitment and distension evaluated by CT-scan

Conditions
-----------------
ARDS

Intervention / Treatment
-----------------
* Device: High frequency percussive ventilation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patient undergoing invasive ventilation for more than 24h ARDS patient Exclusion Criteria: Pneumothorax drained or not Patient undergoing extracorporel mechanical oxygenation Patient who had a pneumonectomy partiel or total

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Transpulmonary pressure controlled mechanical ventilation<br>transpulmonary pressure will be used for ventilation settings | Device: High frequency percussive ventilation<br> <br> |
| No Intervention: Conventional pressure-controlled mechanical ventilation<br>transpulmonary pressure will not be used for ventilation settings | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percent of patients exhibiting under HFPV an increase of at least 15% of normally aerated end-expiratory lung volume |  | 4 hours | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Mechanical ventilation
Cardiac Rhythm Disturbances in Hard-to-treat Epilepsy Patients Using Loop ECG Recorders

Study Overview
=================
Brief Summary
-----------------
Seizure-related cardiac arrhythmias are one of the possible causes of sudden unexpected death in epilepsy (SUDEP). Identification of these patients is challenging because cardiac rhythm disturbances could emerge only during seizures. Furthermore, patients could have transitioned sinus or AV node blocks which could cause syncopes with brady-related seizures which could be treated as epilepsy-related seizures. Implantable loop recorders have an ability to recording single-channel ECG for up to 36 months which give an ability to detect these heart disturbances. The purpose of this study is to look the incidence and types of arrhythmias which occur in 150 patients with hard-to-treat partial seizures and secondarily generalized seizures

Official Title
-----------------
Cardiac Rhythm Disturbances in Hard-to-treat Epilepsy Patients Using Loop ECG Recorders

Conditions
-----------------
Epilepsy

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Hard-to-treat focal epilepsy Aged 18 to 60 years If female not pregnant Exclusion Criteria: Known clinical relevant structural cardiac disease Implanted pacemaker, including cardiac resynchronisation device, or defibrillator Use of beta blockers or other antiarrhythmic medication Diagnosis of psychogenic non-epileptic seizures

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Identification of a dysrhythmia | A dysrhythmia will be defined as either asystole of ≥6 s sinus bradycardia of ≤40 bpm during physical activity 2nd or 3rd-degree AV-block sinus tachycardia of ≥120 bpm nonsustained and sustained monomorphic VT of ≥170 bpm polymorphic VT atrial fibrillation/flutter | 3 years or until the end-of-battery life of Reveal XT, whichever came first | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The number of patients who will have receive the permanent pacemaker at the end of the study. |  | 3 years or until the end-of-battery life of Reveal XT, whichever came first | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Epilepsy, heart block, sudden cardiac death, loop recorder
Features and Outcomes of Patients With Reactive Arthritis

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to assess the incidence and the clinical and therapeutic characteristics of reactive arthritis and to compare them with those of a historical cohort. We hypothesised that improved hygiene together with prevention and treatment of sexually transmitted infections may have decreased the incidence of reactive arthritis.

Official Title
-----------------
A Bicentre Retrospective Study of Features and Outcomes of Patients With Reactive Arthritis

Conditions
-----------------
Arthritis

Intervention / Treatment
-----------------
* Other: Standardised data collection


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: reactive arthritis diagnosed in one of the two rheumatology departments from Centre Hospitalier Lyon Sud or Besançon Exclusion Criteria: presence of other known causes of arthritis, such as other defined spondyloarthritides, septic arthritis, Lyme disease, microcrystalline arthritis or rheumatoid arthritis

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patient with reactive arthritis<br> | Other: Standardised data collection<br>* The following variables will be retrospectively assessed by medical record review using a standardised data collection form:demographics; gender, age; family or personal history of spondyloarthritis, psoriasis, uveitis, inflammatory bowel disease; clinical presentation; mono, oligo or polyarthritis, dactylitis, inflammatory joint pain, enthesopathy, axial symptoms, fever, extra-articular manifestations (conjunctivitis, anterior uveitis, circinate balanitis, skin rash); time interval between infection and musculoskeletal manifestations; causal microorganism if known, or triggering event; HLA-B27; radiographic sacroiliitis; treatments and outcomes (complete recovery at one year follow-up, relapse within 6 months after onset, or spondyloarthritis according to the ASAS criteria).<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To determine the incidence of reactive arthritis in patients hospitalised in the rheumatology department | Incidence of reactive arthritis in patients hospitalised in the rheumatology department | December 2014 |
An Evaluation of the Onset and Duration of Action of AKF-1 Ophthalmic Solution in Treating Acute Allergic Conjunctivitis

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate the onset and duration of action of two concentrations of AKF-1 Ophthalmic Solution compared to vehicle in the conjunctival allergen challenge (CAC) model of acute allergic conjunctivitis.

Conditions
-----------------
Allergic Conjunctivitis

Intervention / Treatment
-----------------
* Drug: AKF-1
* Drug: AKF-1
* Drug: AKF-1


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: positive bilateral conjunctival allergen challenge (CAC) reaction Exclusion Criteria: known contraindications or sensitivities to the study medication or its components any ocular condition that, in the opinion of the investigator, could affect the subjects safety or trial parameters use of disallowed medication during the period indicated prior to the enrollment or during the study

Ages Eligible for Study
-----------------
Minimum Age: 10 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: AKF-1 0.025%<br> | Drug: AKF-1<br>* 1 drop AKF-1 0.025% in each eye at 2 separate times during a 14 day period<br>|
| Experimental: AKF-1 0.035%<br> | Drug: AKF-1<br>* 1 drop AKF-1 0.035% in each eye at 2 separate times during a 14 day period<br>|
| Placebo Comparator: AKF-1 0%<br> | Drug: AKF-1<br>* 1 drop 0% in each eye at 2 separate times during a 14 day period<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ocular Itching at defined time points up to 2 weeks |  | Baseline to day 14 | 
| Ocular Redness at defined time points up to 2 weeks |  | Baseline to day 14 |
Effects of Group Vs. Home-Based Combined Exercise-Diet Program In Childhood Obesity: A Randomised Controlled Trial

Study Overview
=================
Brief Summary
-----------------
The aim of this study was to compare the effect of a hospital group-based vs. home-based combined exercise-diet program for the treatment of childhood obesity.

Official Title
-----------------
Effects of Group Vs. Home-Based Combined Exercise-Diet Program In Childhood Obesity: A Randomised Controlled Trial

Conditions
-----------------
Obesity

Intervention / Treatment
-----------------
* Other: Circuit training


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: caucasian overweight/obese Exclusion Criteria: Subjects with severe obesity (z-score above 2.5)

Ages Eligible for Study
-----------------
Minimum Age: 6 Years
Maximum Age: 16 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Hospital-based exercise program<br>Exercise monitored at the hospital | Other: Circuit training<br>* Aerobic and resistance training exercises + Mediterranean diet<br>|
| Experimental: Home-based exercise program<br>Participants perform exercise at home | Other: Circuit training<br>* Aerobic and resistance training exercises + Mediterranean diet<br>|
| No Intervention: Control<br>Control Group participants maintained their usual levels of daily activity, with no additional exercise components. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Body composition | body mass index (BMI), BMI-Z score | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| waist circumference |  | 6 months | 
| Percentage body fat |  | 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Children, Physical activity, Home-based treatment, Body mass index (z-BMI), Percentage body fat, Waist circumference
Pronostic Value of Endothelial Dysfunction in Heart Failure

Study Overview
=================
Brief Summary
-----------------
The main objective is to evaluate the pronostic value of endothelial dysfonction in acute heart failure on a combined criteria associating cardiovascular mortality, nex hospitalisation for decompensated heart failure, cardiac graft or ventricular assistance 2 month and 1 year before acute heart failure.

Official Title
-----------------
Pronostic Value of Endothelial Dysfunction in Heart Failure

Conditions
-----------------
Heart Decompensation, Cardiac Failure

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients hospitalized for acute heart fialure with Left Ventricular Ejection Fraction (LVEF) < 45 % on echocardiography Exclusion Criteria: Informed consent form not signed Cardiogenic, septic or hemorragic shock Acute coronary syndrom with elevated troponin valvular surgery or aorto-coronary graft during next 3 months Cancer Pregnancy life expectancy over than 1 year chronic renal impairment

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 81 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| MR Proadrenomedulline |  | 6 months | 
| catecholamins |  | 6 months | 
|  |  | 6 months | 
| late endothelial progenitors |  | 6 months | 
| Peripheral tissular perfusion | Near infra-red spectroscopy | 6 months | 
| mortality |  | 6 months | 
| hospitalisation |  | 6 months |
Cardiac Elastography to Determine Strain and Strain Rates in the Heart

Study Overview
=================
Brief Summary
-----------------
Cardiac elastography is a new technique to analyze strain and strain rates in many organ systems, including the heart. In this study, cardiac elastography derived from the analysis of raw radiofrequency data obtained from a conventional clinical echocardiograph system will be compared to processed information that comes from the same echocardiograph system. The purpose of this study is to determine if cardiac elastography can accurately determine strain and strain rates as compared to more conventional means.

Official Title
-----------------
Cardiac Elastography

Conditions
-----------------
Heart Disease

Intervention / Treatment
-----------------
* Procedure: cardiac elastography and echocardiography


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy normal volunteers between the ages of 18-70 Patients scheduled for clinical echocardiogram between the ages of 18-70 who have known heart disease caused by myocardial infarction or cardiomyopathy Exclusion Criteria: Patients less than 18 years old, or greater than 70 years old Patients who do not have adequate quality echocardiographic images.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: cardiac elastography and echocardiography|standard echocardiogram|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
echocardiography, cardiac elastography, Normal volunteers
Immediate Decrease of Muscle Biomechanical Stiffness Following Dry Needling in Asymptomatic Participants

Study Overview
=================
Brief Summary
-----------------
60 healthy participants were randomized into infraspinatus, erector spinae, or gastrocnemius groups. One session of dry needling DN was applied to the muscle in standardized location. Stiffness was assessed using a MyotonPRO at baseline, immediately post DN, and 24 hours later. The presence of a localized twitch response (LTR) during DN was used to subgroup participants.

Official Title
-----------------
Immediate Decrease of Muscle Biomechanical Stiffness Following Dry Needling in Asymptomatic Participants

Conditions
-----------------
Healthy

Intervention / Treatment
-----------------
* Other: dry needling


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: men and women ages 18 to 65 years reported good general health tenderness or palpable trigger point in the muscle (infraspinatus, gastrocnemius, or erector spinae) Exclusion Criteria: BMI > 30kg/m2 surgery in the prior 12 months current pain in the shoulder, low back, and lower leg precautions to dry needling treatment (anticoagulant medications, bleeding disorders, known pregnancy)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Infraspinatus<br>Subjects infraspinatus stiffness was measured and observed | Other: dry needling<br>* Physical therapy<br>|
| Active Comparator: Erector spinae<br>Subjects erector spinae stiffness was measured and observed | Other: dry needling<br>* Physical therapy<br>|
| Active Comparator: Gastrocnemius<br>Subjects gastrocnemius stiffness was measured and observed | Other: dry needling<br>* Physical therapy<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Stiffness | Biomechanical stiffness of the muscle measured, non-invasively using a MyotonPRO. Stiffness (N/m) | Change from baseline and immediately post intervention |