Does Benign Prostatic Obstruction Cause Hypertension?

Study Overview
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Brief Summary
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The known correlation between benign prostatic hypertrophy (BPH) and hypertension could be explained by 3 theoretical pathway models. Whether hypertension causes BPH, BPH causes hypertension or the two are caused by a common factor is currently unknown. In this study it will be investigated whether hypertension is due to the direct effects of infravesical obstruction to urinary outflow in patients with benign prostatic hyperplasia. The approach will be blood pressure measurement in patients who will have a resection of the prostate.

Official Title
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Effect of Transurethral Prostate Resection on 24 Hour Blood Pressure Measurement

Conditions
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Prostatic Hyperplasia, Hypertension

Intervention / Treatment
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* Procedure: 24-hr ambulatory blood pressure measurement


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Listed for inguinal hernia repair or hydrocele repair or transurethral resection of the prostate signed informed consent Exclusion Criteria: Treatment with antihypertensive medication that has been started within 3 months of inclusion. Treatment with antihypertensive medication that has been started after inclusion and before final blood pressure measurements have been obtained 6 months after operation. Any reason that the investigator deems that the participant will not comply with follow-up.

Ages Eligible for Study
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Maximum Age: 65 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| benign prostatic hypertrophy<br>patients who are diagnosed with lower urinary tract symptoms caused by prostatic hypertrophy, undergo transurethral resection of the prostate, and post-surgery 24-hr ambulatory blood pressure measurement. | Procedure: 24-hr ambulatory blood pressure measurement<br> <br> |
| inguinal hernia or hydrocele<br>patients who are diagnosed with lower urinary tract symptoms caused by inguinal hernia or hydrocele, undergo surgical inguinal hernia repair or hydrocele repair, and post-surgery 24-hr ambulatory blood pressure measurement | Procedure: 24-hr ambulatory blood pressure measurement<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change in blood pressure | one measurement 6 weeks pre-surgery, and ambulatory measurement during 6 months post-surgery | 7,5 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| prostate symptom severity assessed by 'International prostate severity score' (questionnaire) | assessed by 'International prostate severity score' (questionnaire) | 7,5 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Transurethral Resection of Prostate