Sound and Music for Mild Cognitive Impairment

Study Overview
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Brief Summary
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Emerging studies in humans found that 40 Hz sound induces neural gamma oscillation and enhanced cognitive function in older adults with and without Alzheimer's Disease. We will compare a 40 Hz music intervention to both 40 Hz sound and music alone in a clinical cohort of older adults with mild cognitive impairment.

Official Title
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The Power of Sound and Music Interventions for Older Adults With Mild Cognitive Impairment

Conditions
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Mild Cognitive Impairment

Intervention / Treatment
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* Behavioral: A: 40 Hz music
* Behavioral: B: 40 Hz sound
* Behavioral: C: Preferred music


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Community-dwelling amnesia mild cognitive impairment Preserved function No dementia Exclusion Criteria: known diagnosis of schizophrenia or Parkinson's disease; severe hearing impairment; presence of an acute medical or psychiatric condition which would interfere with the subject's ability to follow the study protocol realistically

Ages Eligible for Study
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Minimum Age: 50 Years
Maximum Age: 95 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>this group will be exposed to condition A first, then B, and C | Behavioral: A: 40 Hz music<br>* The participant will listen to the 40 Hz music playlist one hour each day, 5 days a week for 4 weeks<br>Behavioral: B: 40 Hz sound<br>* The participant will listen to the 40 Hz sound playlist one hour each day, 5 days a week for 4 weeks<br>Behavioral: C: Preferred music<br>* The participant will listen to the preferred music playlist one hour each day, 5 days a week for 4 weeks<br>|
| Experimental: 2<br>this group will be exposed to condition B first, then C, and A | Behavioral: A: 40 Hz music<br>* The participant will listen to the 40 Hz music playlist one hour each day, 5 days a week for 4 weeks<br>Behavioral: B: 40 Hz sound<br>* The participant will listen to the 40 Hz sound playlist one hour each day, 5 days a week for 4 weeks<br>Behavioral: C: Preferred music<br>* The participant will listen to the preferred music playlist one hour each day, 5 days a week for 4 weeks<br>|
| Experimental: 3<br>this group will be exposed to condition C first, then A, and B | Behavioral: A: 40 Hz music<br>* The participant will listen to the 40 Hz music playlist one hour each day, 5 days a week for 4 weeks<br>Behavioral: B: 40 Hz sound<br>* The participant will listen to the 40 Hz sound playlist one hour each day, 5 days a week for 4 weeks<br>Behavioral: C: Preferred music<br>* The participant will listen to the preferred music playlist one hour each day, 5 days a week for 4 weeks<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Cognitive function | Cogstate computerized assessment will be used to measure cognitive function. Higher score represents better cognitive function | Baseline and immediately after the 4-week intervention |