Detecting the Influence of Cataract Surgery on the Development of Diabetic Retinopathy in Patients With Diabetes Mellitus Type 2 With and Without Diabetic Retinopathy Using OCT Angiography

Study Overview
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Brief Summary
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Detecting the influence of cataract surgery on the development of diabetic retinopathy in patients with diabetes mellitus type 2 with and without diabetic retinopathy using OCT angiography.

Detailed Description
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Patients with diabetes mellitus type 2 with and without without diabetic retinopathy (on biomicroscopy examination) who need cataract surgery, will undergo OCT angiography examination prior to their cataract surgery. Average vessel density (%) in superficial capillary plexus, deep capillary plexus and choriocapillaris, parafoveal vessel density (%) in the superficial and deep plexuses, FAZ area (mm2) in the superficial capillary plexus, FAZ circularity, retinal thickness, microaneurysms and capillary non-perfusion will be taken into analysis. Patients will be examined on the first day after the cataract surgery with phacoemulsification and in the bag posterior chamber lens implantation. All patients will undergo OCT angiography examination four weeks after their cataract surgery.

Official Title
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OCT Angiography Changes in Patients With Diabetes Mellitus Type 2 With and Without Diabetic Retinopathy Undergoing Phacoemulsification

Conditions
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Diabetic Retinopathy

Intervention / Treatment
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* Device: Phacoemulsification


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with diabetes mellitus type 2 with and without diabetic retinopathy who needs cataract surgery. Patients who need cataract surgery without any intravitreal injections. Absence of any ocular disease other than diabetes mellitus. Cataract density allowing good visualization of the fundus by OCT angiography. Patients with uneventful cataract surgery with phacoemulsification. Exclusion Criteria: Patients who fail to comply with the follow-up schedule. Very dense cataract not allowing good visualization of the fundus by OCT angiography. Patients with complicated cataract surgery with phacoemulsification. Patients who need cataract surgery with any intravitreal injection.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Diabetics type 2 with and without diabetic retinopathy<br>Patients with diabetes mellitus type 2 with and without diabetic retinopathy who needs cataract surgery by phacoemulsification. All patients will undergo OCT angiography examination prior to their cataract surgery and 4 weeks after the cataract surgery. | Device: Phacoemulsification<br>* Cataract surgery and in the bag posterior chamber lens implantation<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Detecting changes in the retinal vascular plexuses and choriocapillaris after cataract surgery in type 2 diabetes mellitus patients with and without diabetic retinopathy using OCT angiography. | Changes in the retinal vascular plexus, superficial and deep vessel density, foveal avascular zone area, circularity and any developing microaneurysms and areas of retinal ischemia will be measured to see the influence of cataract surgery on diabetic retinopathy. | 1 month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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OCT angiography, Diabetic retinopathy, Cataract surgery