Aerobic Exercises for Multiple Sclerosis

Study Overview
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Brief Summary
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Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) .It is the most common neurological disorders affecting young adults.Multiple sclerosis is an autoimmune disease that results in progressive neural degeneration. Cytokines play an important role in the pathogenesis and treatment of MS.

Detailed Description
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This research aims to evaluate the effect of aerobic exercises on the immune system anti-inflammatory (IL-10) and pro inflammatory (IL-17) cytokines and its consequences on the functional status in the Multiple Sclerosis patients. Aerobic exercises are a term to describe planned, structured and repetitive physical activity undertaken over a prolonged period to maintain or improve physical fitness and functional capacity .

Official Title
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Effect of Aerobic Exercises on Immune System in Patients With Multiple Sclerosis

Conditions
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Multiple Sclerosis, Primary Progressive

Intervention / Treatment
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* Other: aerobic exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age ranged from 25 to 45 years. All the patients were remitting relapsing MS according to (revised McDonald criteria. Duration of MS disease was one to two years before starting of the study. Last attack occurred three months ago. All patients were able to ambulate Exclusion Criteria: Patients with other neurological deficits , patient with significant orthopedic abnormalities for both lower limbs, patient with contracture , patient with deformities, pregnant females

Ages Eligible for Study
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Minimum Age: 25 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: study group (GA) and control group (GB) in addition to normal matched subjects (GC).The control group (GB)was treated by the disease modifying drug (interferon beta-1a) Rebif, (GA) treated by the same drug in addition to a physical therapy program of aerobic exercises for 40 min included bicycle ergometry training
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: the study group<br>the study group (GA) was treated only by the disease modifying drug (interferon beta-1a) in addition to aerobic exercise. | Other: aerobic exercise<br> <br> |
| No Intervention: the control group<br>control group (GB)was treated only by the disease modifying drug (interferon beta-1a) | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| blood analysis | serum anti inflammatory cytokine IL-10, | serum anti inflammatory cytokine IL-10, will be assessed at 0 day | 
| blood analysis | serum anti inflammatory cytokine IL-10, | serum anti inflammatory cytokine IL-10, wil lbe assessed at 90 day | 
| blood analysis | pro inflammatory cytokine IL-17 | pro inflammatory cytokine IL-17 will be assessed at 0 day | 
| blood analysis | pro inflammatory cytokine IL-17 | pro inflammatory cytokine IL-17 will be assessed at 90 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Multiple Sclerosis, Aerobic exercises, cytokine IL-10, cytokine IL-17