Analysis of Postural Control of COPD Patients (ATTRACTION)

Study Overview
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Brief Summary
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Chronic Obstructive Pulmonary Disease (COPD) is a common chronic respiratory disease, causing disabling respiratory symptoms and impairing patients' quality of life. Currently one of the leading causes of death worldwide, COPD is a major socio-economic concern. It is also accompanied by extremely frequent extra-respiratory manifestations (or co-morbidities). Among these secondary manifestations, the equilibrium of these patients is subject to modifications: thus, numerous studies have shown that the equilibrium of COPD patients was altered compared to healthy age-matched subjects. This alteration is associated with a greater functional limitation and a higher risk of falling. Although this impairment has been demonstrated clinically, the balance of these patients has never been analysed using quantified movement analysis tools during tasks similar to those performed in daily life. Moreover, the underlying mechanisms remain unknown and the possible associations with several clinical factors of interest (pain, dyspnea, muscle function...) have not yet been assessed. The hypotheses of this project are that (1) the postural control of COPD patients is altered compared to healthy subjects during tasks of daily living and these changes can be characterised. (2) Several clinical factors are associated with these changes.

Official Title
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Quantified Analysis of Postural Control of COPD Patients During Tasks of Daily Living

Conditions
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Chronic Obstructive Pulmonary Disease

Intervention / Treatment
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* Other: quantified analysis of postural control during activities of daily living


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: COPD patients GOLD stage 2 and 3 (A-D) In accordance with Article L1121-8-1 of the Public Health Code, participants must be affiliated to a social security scheme or benefit from such a scheme. Exclusion Criteria: the presence of long-term or exercise-based oxygen therapy, the presence of a medically diagnosed pathology causing manifest disorders of balance, the inability to walk 150 m without stopping and to climb or descend stairs, a history of pneumonectomy or lobectomy within the last six months, the existence of an acute respiratory exacerbation within the last two months, the presence of obvious cognitive impairment that impairs comprehension of instructions, body mass index less than 21 or more than 35 kg/m². Person referred to in articles L. 1121-5 to L. 1121-8 and L. 1121-12 of the public health code: Pregnant woman, woman in labour or nursing mother Person deprived of liberty by judicial or administrative decision Person hospitalised without consent and not subject to a legal protection measure, and person admitted to a health or social establishment for purposes other than research Minor Person subject to a period of exclusion for other research Person of full age subject to a legal protection measure (guardianship, curatorship or safeguard of justice), person of full age unable to express their consent and not subject to a protection measure Person under psychiatric care
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| COPD patients<br> | Other: quantified analysis of postural control during activities of daily living<br>* functional tests that reproduce tasks of daily living (timed up and go test with and without dual cognitive task, modified Glittre ADL test)<br>|
| Healthy controls<br> | Other: quantified analysis of postural control during activities of daily living<br>* functional tests that reproduce tasks of daily living (timed up and go test with and without dual cognitive task, modified Glittre ADL test)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Margins of stability | Postural control parameter related to the centre of mass (CoM) and the base of support of the participant, assessed during the functional tests | Clinical assessment at baseline | 
| Margins of stability variability | Coefficient of variation of a postural control parameter related to the centre of mass (CoM) and the base of support of the participant, assessed during the functional tests | Clinical assessment at baseline | 
| Center of Mass velocity | Parameter of participant's Centre of Mass (CoM) during the functional tests | Clinical assessment at baseline | 
| Center of mass displacement | Parameter of participant's Centre of Mass (CoM) during the functional tests | Clinical assessment at baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evolution of articular angulations | Articular angulations assessed at the ankle, knee, hip, spine and thoracic level during the functional tests | Clinical assessment at baseline | 
| Centre of pressure (CoP) Area | Parameter of participant's Centre of Pressure (CoP) during the sit to stand and stand to sit tasks of the Glittre-ADL test | Clinical assessment at baseline | 
| Centre of pressure (CoP) velocity | Parameter of participant's Centre of Pressure (CoP) during the sit to stand and stand to sit tasks of the Glittre-ADL test | Clinical assessment at baseline | 
| Centre of pressure (CoP) variability | Coefficient of variation of participant's Centre of Pressure (CoP) during the sit to stand and stand to sit tasks of the Glittre-ADL test | Clinical assessment at baseline | 
| Gait Cadence | spatio-temporal parameter of gait assessed during the walking part of the Glittre-ADL test | Clinical assessment at baseline | 
| Gait velocity | spatio-temporal parameter of gait assessed during the walking part of the Glittre-ADL test | Clinical assessment at baseline | 
| Gait phases duration | spatio-temporal parameter of gait assessed during the walking part of the Glittre-ADL test | Clinical assessment at baseline | 
| Step width | spatio-temporal parameter of gait assessed during the walking part of the Glittre-ADL test | Clinical assessment at baseline | 
| Step length | spatio-temporal parameter of gait assessed during the walking part of the Glittre-ADL test | Clinical assessment at baseline | 
| Completion time of the Modified Glittre ADL | Time to complete the modified Glittre-ADL test | Clinical assessment at baseline | 
| Completion time of the timed up and go test | Time to complete the timed up and go test test | Clinical assessment at baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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chronic obstructive pulmonary disease, postural balance, activities of daily living