Cognitive Dysfunction in COPD Patients : Role in the Performance of Cognitive-motor Dual Task Situation?

Study Overview
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Brief Summary
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Chronic Obstructive Pulmonary Disease (COPD) is a respiratory disease starting point characterized by multiple systemic effects as cognitive dysfunction. This one seems to have an impact in activity daily living, considered mainly as a cognitive-motor dual task situations. Yet to date, no study has specifically focused in the cognitive-motor performance in patients with COPD or on the effects during a rehabilitation program. The main objective of this work was to evaluate the impact of cognitive dysfunction in COPD, comparing performance between COPD patients and healthy subjects in a single and dual task cognitive-motor situation. The secondary objective was to assess the impact of a rehabilitation program on these performances.

Official Title
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Impact of Cognitive Dysfunction in Chronic Obstructive Pulmonary Disease on Performance in Cognitive-motor Dual Task Situation

Conditions
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Chronic Obstructive Pulmonary Disease

Intervention / Treatment
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* Other: Cognitive and motor performances


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Male or female about 40 to 80 years old COPD patient (Tiffeneau <70%); stage moderate to severe (Stage 2,3 and 4) with or without oxygen therapy (>15h/day) Written and informed consent of the subject Authorization to physical activity referring doctor in the clinic Comorbidities no dominating Exclusion Criteria: Subject with neurological pathology, cognitive or psychiatric Subject with pain and / or plantar injuries Subject has a prosthetic knee and / or hip. Subject requiring walking aid (cane, walker, etc.)

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Volunteers<br>Cognitive and motor performances were measured in a single and dual task situations. | Other: Cognitive and motor performances<br> <br> |
| COPD patients<br>Cognitive and motor performances were measured in a single and dual task situations, before rehabilitation, and compared to those of healthy subjects. Then, Chronic Obstructive Pulmonary Disease patients were re-evaluated after rehabilitation. | Other: Cognitive and motor performances<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Variability of Cognitive performances in a single and dual task situations | Cognitive performance were determined by error count and number of substraction during a counting task. | 3 months | 
| Variability of motor performances in a single and dual task situations | Motor performance were determined by variability of length and surface of postural condition and by step variability in locomotion condition | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Effect of rehabilitation program on Cognitive performances in a single and dual task | Comparison before and after rehabilitation program of counting task (number of substraction and error count) | 3 months | 
| Effect of rehabilitation program on motor performances in a single and dual task | Comparison before and after rehabilitation program of variability of length and surface of postural condition and step variability in locomotion condition | 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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cognitive dysfunction, Activity of Daily Living, interference, rehabilitation, cognitive-motor dual task