linjc16/ctgov huggingface dataset:
Zirconia and Metal-based Single Crown Posterior Restorations.

Study Overview
=================
Brief Summary
-----------------
The objective of this study was to compare the 5-year survival and clinical behavior of single posterior ceramic crowns made with pressable ceramic on zirconia or on a metal framework. If failures occurred, the further aim of the study was to delineate the factors contributing to the failure. The null hypothesis stated that the survival of zirconia-based restorations would be no worse that those made with metal-based material.

Official Title
-----------------
Zirconia-based and Metal-based Single Crown Posterior Restorations: 5-year Results of a Randomized Controlled Clinical Study.

Conditions
-----------------
Dental Crowns, Dental Prosthesis, Prosthodontics

Intervention / Treatment
-----------------
* Device: dental crowns


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Informed Consent as documented by signature Male and female patients from 18-70 years of age Need for a single crown restoration Presence of antagonist minimum of 20 teeth moderate to good oral hygiene with the ability to perform mechanical oral hygiene techniques including tooth brushing low to moderate caries risk, and no active periodontal disease. Exclusion Criteria: Women who are pregnant at the date of inclusion Known or suspected non-compliance, drug or alcohol abuse Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant Smoking more than 15 cigarettes a day Poor oral hygiene (Plaque Index over 30%) Bruxism vital teeth allergic reaction or hypersensitivity to ingredients of the adhesive or restorative material

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: metal-based restorations<br>single crown with a metal framework and pressed ceramic | Device: dental crowns<br> <br> |
| Experimental: zirconia-based restorations<br>single crown with a zirconia framework and pressed ceramic | Device: dental crowns<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Technical complication rate | assessed by USPHS-criteria | 5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Survival rate | assessed by bleeding on probing | 1, 3, 5 years | 
| Survival rate | pocket probing depth | 1, 3, 5 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
cad/cam, dental porcelain, zirconia, press on metal
Study to Evaluate the Product Performance of a New Silicone Hydrogel Contact Lens

Study Overview
=================
Brief Summary
-----------------
This will be a randomized non-dispensing study comparing the overnight corneal swelling of an eye while wearing no contact lens to the Ultra contract lens.

Official Title
-----------------
The Study to Evaluate the Product Performance of a New Silicone Hydrogel Contact Lens

Conditions
-----------------
Corneal Deformity

Intervention / Treatment
-----------------
* Device: B&L Investigational Contact Lens


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Be between 18 and 40 years of age (inclusive) Not a current contact lens wearer (have not worn extended wear, and not worn in lenses in 6 months) Able to read, comprehend and sign an informed consent Willing to comply with the wear and study visit schedule Monocular best-corrected distance visual acuity >/-20/25 in each eye Exclusion Criteria: Any active corneal infection, disease, injury, inflammation, past surgery, or ocular abnormality which may interfere with contact lens wear Systemic or ocular allergies, which might interfere with contact lens wear Systemic disease or condition, which might interfere with contact lens wear Use of prescription sleep aids or alcohol within 24 hours of study appointment Inability to wear contact lenses Under 18 years of age

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Study Group 1<br>1st overnight visit with no contact lens; 2nd overnight visit randomized to either left or right eye for B&L Investigational Contact Lens | Device: B&L Investigational Contact Lens<br>* The lens used in this study will be supplied by the Sponsor. All subjects will wear a -3.00D lens.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percent Change in Central Corneal Thickness | Percent change in central corneal thickness from evening to morning (after 8 hours with lid closed) | 8 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time to Restore Central Corneal Thickness | Time (hours) to restore central corneal thickness to its baseline value after lens removal | 48 hours |
Comparison of Laparoscopic Cornuostomy and Wedge Resection for Interstitial Pregnancy

Study Overview
=================
Brief Summary
-----------------
This retrospective study is to find out the best way to treat patient with cornual pregnancy in the aspect of further pregnancy outcome.

Detailed Description
-----------------
To find out the best way to treat patient with cornual pregnancy in the aspect of further pregnancy outcome, the investigators compared the outcomes of laparoscopic wedge resection (LWR) and laparoscopic cornuostomy (LC) by the retrospective chart review.

Official Title
-----------------
Comparison of Laparoscopic Cornuostomy and Wedge Resection for Interstitial Pregnancy

Conditions
-----------------
Cornual Pregnancy

Intervention / Treatment
-----------------
* Procedure: Cornual pregnancy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All women with cornual pregnancy who were admitted to the Department of Obstetrics and Gynecology of the Far Eastern Memorial Hospital for laparoscopic surgeries between January 2008 and June 2016 were enrolled Exclusion Criteria: The person who was pregnant at the time of the operation After receiving IVF course of treatment Patients with uterine horns undergoing open surgery

Ages Eligible for Study
-----------------
Minimum Age: 20 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| cornuostomy<br>cornuostomy | Procedure: Cornual pregnancy<br>* we will get the information of operative time, blood loss and postoperative pregnancy and delivery rate.<br>|
| wedge resection<br>wedge resection | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| pregnancy rate | Comparison of pregnancy rates between the cornuostomy and wedge resection groups | 9 years |
Visceral Leishmaniasis and Malnutrition in Amhara Regional State, Ethiopia

Study Overview
=================
Brief Summary
-----------------
The project Visceral Leishmaniasis and Malnutrition is a cohort study that aimed to assess the association between malnutrition and visceral leishmaniasis (VL). It was conducted in Libo Kemkem and Fogera districts of the Amhara Regional State in Ethiopia. Clinical, anthropometric, biochemical, immunological, parasitological and sociodemographic data of school age children from VL high prevalence communities were collected in December 2009, May 2010 and February 2011.

Official Title
-----------------
Visceral Leishmaniasis and Malnutrition in Amhara Regional State, Ethiopia

Conditions
-----------------
Malnutrition, Visceral Leishmaniasis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Reported age between 4 and 15 years of age Currently living in the selected household Exclusion Criteria: To be ill of visceral leishmaniasis at the time of the survey To be positive to visceral leishmaniasis infection tests at the time of the first survey To be under treatment for visceral leishmaniasis at the time of the survey To be extremely ill of any other condition

Ages Eligible for Study
-----------------
Minimum Age: 4 Years
Maximum Age: 15 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Malnourished<br>Children with either height for age z score or body mass index for age z score below 2 standard deviations according to the World Health Organization Growth Standards for children younger than 5 years and the 2007 WHO Growth Reference for children of 5 years or older. | |
| Not malnourished<br>Children with either height for age z score or body mass index for age z score equal or higher than 2 standard deviations according to the World Health Organization Growth Standards for children younger than 5 years and the 2007 WHO Growth Reference for children of 5 years or older. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| visceral leishmaniasis disease |  | December 2009, May 2010 and February 2011 (up to 14 months) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| visceral leishmaniasis infection |  | December 2009, May 2010 and February 2011 (up to 14 months) | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Visceral leishmaniasis, kala azar, malnutrition, stunting, thinness, Leishmania donovani
Healing of Persistent Epithelial Defects

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to compare the relative efficacy of four different treatment modalities (i.e. aggressive lubrication, bandage contact lens, Ambiodisk amniotic membrane, Prokera amniotic membrane) in the healing of persistent corneal epithelial defects following retina surgery.

Official Title
-----------------
Comparison of Standard of Care Treatments for Post-operative Non-healing Epithelial Defects

Conditions
-----------------
Cornea

Intervention / Treatment
-----------------
* Drug: carboxymethylcellulose sodium
* Device: Acuvue Oasys Bandage Contact Lens
* Device: Ambiodisk
* Device: Prokera


Participation Criteria
=================
Eligibility Criteria
-----------------
3.1 Inclusion Criteria Adults aged 18 and older (inclusive) at the time of study enrollment Recent history of retina surgery Presence of persistent epithelial defect 7 days or later after surgery English speaking 3.2 Exclusion Criteria Non-English speaking patients Inability to incapacity to provide consent for the study History of corneal epithelial or limbal stem cell disease

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Lubrication<br> | Drug: carboxymethylcellulose sodium<br>* frequent topical lubrication with artificial tears<br>|
| Active Comparator: Bandage Contact Lens<br>Acuvue Oasys Contact Lens | Device: Acuvue Oasys Bandage Contact Lens<br> <br> |
| Active Comparator: Prokera<br>Wet amniotic membrane mounted on plastic retaining ring | Device: Prokera<br> <br> |
| Active Comparator: Ambiodisk<br>Freeze dried amniotic membrane | Device: Ambiodisk<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Abscence of persistent epithelial defect |  | 22 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of epithelial healing in mm2/day |  | 22 days | 
| Infection |  | 22 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
epithelial defect, amniotic membrane, cornea
Accuracy of BabySat V3 With Profound Hypoxia and Motion

Study Overview
=================
Brief Summary
-----------------
Performance testing of pulse oximeters. The protocol involves brief stable arterial oxygen desaturation in healthy volunteers and sampling arterial blood when a stable level of hypoxia has been attained and during different motion scenarios. The blood sample is analyzed for oxygen saturation with a gold standard bench CO-oximeter. This protocol is aligned with the latest ISO and FDA guidance documents for pulse oximeter testing.

Official Title
-----------------
Accuracy of BabySat V3 With Profound Hypoxia and Motion

Conditions
-----------------
Hypoxia

Intervention / Treatment
-----------------
* Device: BabySat V3


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: The subject is male or female, aged ≥18 and <50 The subject is in good general health with no evidence of any medical problems The subject is fluent in both written and spoken English The subject has provided informed consent and is willing to comply with the study procedures Exclusion Criteria: The subject is obese (BMI>30). The subject has a known history of heart disease, lung disease, kidney or liver disease. Diagnosis of asthma, sleep apnea, or use of CPAP. Subject has diabetes. Subject has a clotting disorder. The subject a hemoglobinopathy or history of anemia, per subject report or the first blood sample, that in the opinion of the investigator, would make them unsuitable for study participation. The subject has any other serious systemic illness. The subject is a current smoker. Any injury, deformity, or abnormality at the sensor sites that in the opinion of the investigators' would interfere with the sensors working correctly. The subject has a history of fainting or vasovagal response. The subject has a history of sensitivity to local anesthesia. The subject has a diagnosis of Raynaud's disease. The subject has unacceptable collateral circulation based on exam by the investigator (Allen's test). The subject is pregnant, lactating or trying to get pregnant. The subject is unable or unwilling to provide informed consent, or is unable or unwilling to comply with study procedures. The subject has any other condition, which in the opinion of the investigators' would make them unsuitable for the study.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 49 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: BabySat V3|Evaluation of Accuracy of BabySat V3|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluation of accuracy during motion | Determine the accuracy during varying degrees of motion and oxygen saturation | During the oxygen desaturation assessment |
Assessment of Efficiency and Safety of an Infant Formula Containing a Probiotic in Children

Study Overview
=================
Brief Summary
-----------------
Evaluate the effect of probiotics on stool output in children 1 - 18 months old.

Detailed Description
-----------------
Evaluate the effect of probiotics on stool output in children 1 - 18 months old.

Official Title
-----------------
Assessment of Efficiency and Safety of an Infant Formula Containing a Probiotic in Children

Conditions
-----------------
Stool Output

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: children 1 - 18 months of age acute diarrhea adequately hydrated signed informed consent Exclusion Criteria: exclusively or predominantly breast-feeding bloody diarrhea intercurrent illnesses that may affect study parameters use of systemic antibiotics during the 72 hours prior to enrollment use of anti-diarrheal medications at the time of enrollment use of supplement or infant formula with Lactobacillus rhamnosus 10 days prior to enrollment

Ages Eligible for Study
-----------------
Minimum Age: 1 Month
Maximum Age: 18 Months

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Control<br>Routine cow milk-based infant formula | |
| Investigational<br>Cow milk-based infant formula containing probiotics | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Enumeration and Molecular Characterization of Circulating Tumour Cells in Women With Metastatic Breast Cancer

Study Overview
=================
Brief Summary
-----------------
Women with metastatic breast cancer, receiving first line treatment of any kind (chemotherapy, endocrine treatment or treatment with antibodies) will be included in this trial. In connection to treatment, blood samples for determination and enumeration of circulating tumour cells will be collected at different time points. Serum and plasma will be collected and stored for future analysis of RNA and DNA.

Official Title
-----------------
Enumeration and Molecular Characterization of Circulating Tumour Cells in Women With Metastatic Breast Cancer

Conditions
-----------------
Metastatic Breast Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Women with metastatic breast cancer ECOG performance status 0-2 Age over18 years Signed informed concent Predicted life expectancy over 2 months Planned for first line systemic treatment for metastatic disease (chemotherapy, antibody treatment or endocrine treatment) Standard imaging evaluation within 4 weeks of inclusion Planned for standard imaging within 16 weeks after start of therapy Exclusion Criteria: Prior medical therapy for metastatic disease (prior adjuvant chemotherapy, radiotherapy or endocrine therapy is permitted) Inability to understand information about the study Other malignant disease with the exception of curatively treated basal cell or squamous cell cancer of the skin and cancer in situ of the cervix

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Blood sampling.<br>Blood samples will be taken before start of treatment, at month 1, month 3, month 4 and month 6. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To determine whether numbers of circulating tumour cells in peripheral blood can give information of prognosis, and to evaluate if the numbers of circulating tumour cells can give information of the efficacy of given treatment |  | Blood samples will be taken before start of treatment, at month 1, month 3, month 4 and month 6. | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
CTC, Metastatic breast cancer, Circulating tumour cells, Prognostic factors, Treatment response
Review of the Pathological Results of Appendectomy Specimens

Study Overview
=================
Brief Summary
-----------------
This is a retrospective review study to evaluate the histopathological findings post appendectomy

Detailed Description
-----------------
In this study, 940 cases will be reviewed. Patient demographics, accuracy of imaging modalities, and histopathological findings will be described.

Official Title
-----------------
Histopathological Examination of Cases With Acute Appendicitis, A Retrospective Study at King Abdulaziz University Hospital, Jeddah, Saudi Arabia

Conditions
-----------------
Appendicitis, Pathology, Acute Appendicitis, Appendicitis (Diagnosis)

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients underwent an appendectomy in king Abdulaziz university hospital in the period between 2010-2017 Exclusion Criteria: Any other patients will be excluded from the study
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Description of histopathological findings post appendectomy | Description of histopathological findings post appendectomy | 2010-2017 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Relation between disease age, and gender | Relation between disease age, and gender | 2010-2017 | 
| Assessment for accuracy of imagining modalities | Assessment for accuracy of imagining modalities | 2010-2017 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Appendix, Pathology, Appendicitis diagnosis, Acute appendicitis