Effects of ASMR on the Default Mode Network

Study Overview
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Brief Summary
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This study investigates the effects of Autonomous Sensory Meridian Response (ASMR) stimulation on resting-state brain networks. Therefore, two resting-state fMRI scans are measured in healthy adults. Before each fMRI scan, subjects listen either to ASMR typical sounds or an audio-book (randomized cross-over-design). It is expected to find changes in the functional connectivity of the Default Mode Network caused by passive listening to ASMR.

Detailed Description
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ASMR describes a phenomenon of a perceived tingling caused by visual or auditory stimulation. This sensation can spread from the neck to the scalp and further to the back and the extremities. The triggering sound often consists of acoustic sounds (crackle, whisper, light nail-tapping) or visual images (e.g., someone is combing their hair), leading to a calm and relaxing feeling. Although ASMR is ubiquitous in platforms like YouTube, there are just a few studies investigating the effects of ASMR. In one of those studies, Smith and colleagues examined the Default Mode Network of 11 subjects with ASMR stimulation and compared the outcome with a control group consisting of 11 subjects. They found reduced functional connectivity in the ASMR group compared to the control group. Furthermore, the connectivity between the occipital, frontal and temporal cortex was increased. In the present study, fMRI is used to examine the effects of ASMR stimulation in a randomized cross-over design. Half of the subjects (n=14) receive the ASMR stimulation first, and then the control stimulation (audiobook). The other half of the subjects (n=14) listens to the control stimulation (audiobook) first and afterward to the ASMR stimulation. Typical tingling triggering sounds are presented via MRI-compatible headphones. Those sounds can consist of different noises (e.g., whisper, scratching, and knocking). The primary outcome measure is a change in the functional connectivity of the Default Mode Network as a response to the ASMR stimulation.

Official Title
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Investigating the Effects of Autonomous Sensory Meridian Response (ASMR) Stimulation on the Functional Connectivity of the Default Mode Network

Conditions
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Autonomous Sensory Meridian Response, Audiobook

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: adults aged 18 to 99 Exclusion Criteria: mental disorders (dementia, depression) MRI contraindications claustrophobia

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 99 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changed functional connectivity | Functional connectivity is measured using resting-state fMRI | 45 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Autonomous Sensory Meridian Response, Resting-state fMRI, Default Mode Network