Quadratus Lumborum Block Versus Transversus Abdominus Plane Block for Pain Management After Donor Nephrectomy

Study Overview
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Brief Summary
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To evaluate quadratus lumborum block effect on post operative pain scores during the first 24 hours after surgery as compared to transversus abdominis plane block after laparoscopic donor nephrectomy patients.

Official Title
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Quadratus Lumborum Block Versus Transversus Abdominus Plane Block for Pain Management After Donor Nephrectomy

Conditions
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Kidney Donor

Intervention / Treatment
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* Procedure: QL Block
* Procedure: TAP Block


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients undergoing laparoscopic assisted donor nephrectomy Patients that have elected to have a nerve block 18 years of age or older Patients of ASA status I - III Exclusion Criteria: Chronic pain or narcotic usage during the preceding 30 days Infection at or near the intended needle insertion site Complex or altered abdominal wall anatomy Weight <45kg

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: QL Block<br>Blocks will be performed under the supervision of a regional anesthesia attending experienced in the performance QL blocks. QL block will be performed using ropivacaine 0.375% 20ml each side for a total volume of 40cc. | Procedure: QL Block<br>* Blocks will be performed under the supervision of a regional anesthesia attending experienced in the performance QL blocks. QL block will be performed using ropivacaine 0.375% 20ml each side for a total volume of 40cc.<br>|
| Active Comparator: TAP Block<br>Blocks will be performed under the supervision of a regional anesthesia attending experienced in the performance TAP blocks. TAP block will be performed using ropivacaine 0.375% 20ml each side for a total volume of 40cc. | Procedure: TAP Block<br>* Blocks will be performed under the supervision of a regional anesthesia attending experienced in the performance TAP blocks. TAP block will be performed using ropivacaine 0.375% 20ml each side for a total volume of 40cc.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Average Pain Score | NRS patient reported (number rated pain score, 0=no pain - 10=highest pain) over the first 24 hours post operative. | 24 hours post operative | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Total Cumulative Opioids | opiate consumption first 72 hours post operatively | 72 hours | 
| Number of Participants With Nausea or Emesis Requiring Antiemetic Medication | Antiemetics given in PACU. Occurrence of nausea or emesis requiring antiemetic medication administration in PACU. | 24 hours | 
| Number of Participants With Block Related Complications |  | 24 hours | 
| Length of Stay in Post Anesthesia Care Unit (PACU) | Duration of PACU stay. | 24 hours | 
| Length of Hospital Stay | The time from surgery completion to subject meeting discharge criterion. | 3 days |