Evaluation of Kidney Graft's Fibrosis With Real Time Shear-wave Elastography

Study Overview
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Brief Summary
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Kidney graft's fibrosis is correlated with prognostic of kidney's graft, wathever the initial etiology. Actually, that evaluation is based on histologic score of Banff FI/AT (0 to III). It is obtained thanks to punction-biopsy, which is invasive and can lead complications. This exam is systematic on M3 of the transplantation. Tissue's fibrosis is a proliferation of extracellular matrix, leading to an increase of fibrosed tissue rigidity. Elastography is an ultrasound technique allowing evaluation of tissues' rigidity. The purpose is the validation of elastograhpy, innovative and non -invasive technique, and more specifically Shear Wave Elastography (SWE). For this, strain ratio (SR) could improve intra-operator variability and estimate fibrosis' degree of kidney's graft.

Detailed Description
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Kidney graft's fibrosis is correlated with prognostic of kidney's graft, wathever the initial etiology. Actually, that evaluation is based on histologic score of Banff FI/AT (0 to III). It is obtained thanks to punction-biopsy, which is invasive and can lead complications. This exam is systematic on M3 of the transplantation. Tissue's fibrosis is a proliferation of extracellular matrix, leading to an increase of fibrosed tissue rigidity. Elastography is an ultrasound technique allowing evaluation of tissues' rigidity. The purpose is the validation of elastograhpy, innovative and non -invasive technique, and more specifically Shear Wave Elastography (SWE). For this, strain ratio (SR) could improve intra-operator variability and estimate fibrosis' degree of kidney's graft.

Official Title
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Evaluation of Kidney Graft's Fibrosis With Real Time Shear-wave Elastography

Conditions
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Kidney Graft

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Kidney-transplanted patient, whatever kind of organ donation ( alive donor, deceased donor included extended criteria Maastricht 2 or 3) More than 18 years-old Exclusion Criteria: Dual kidney graft Hydronephrosis / urinary obstacle Pathologies with an intrinsic compression on the graft Stenosis hemodynamically significant of graft artery (lengthening of Systolic Ascent Time > 70 ms) Contra-indication to systematical punction-biopsy on Month 3 : Ischemia of post-transplanted graft Alive donor HLA identical Hemostasis disorder or unable to stop antiaggregant or anticoagulant Hydronephrosis / urinary obstacle Opposition to use the data

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| measure of shear wave elastography | Evaluation of shear wave elastography real time as biomarker of kidney graft's fibrosis | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Strain Ratio measure | - Intra-operator variability of Strain Ratio measure | 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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fibrosis, kidney graft, elastography