linjc16/ctgov huggingface dataset:
Clinical Efficacy of Conservative Treatment in Female Patients With Plevic Congestion Syndrome

Study Overview
=================
Brief Summary
-----------------
The article presents the results of a randomized, placebo-controlled study of the conservative treatment with Daflon (Detralex) in female patients with Pelvic congestion syndrome .

Official Title
-----------------
Clinical Efficacy of Conservative Treatment in Female Patients With Plevic Congestion Syndrome

Conditions
-----------------
Pelvic Congestion Syndrome

Intervention / Treatment
-----------------
* Drug: Daflon


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: •The presence of pelvic varicose veins verified by transvaginal and transabdominal duplex ultrasound scanning Exclusion Criteria: Severe disease of the gastrointestinal tract or hematopoietic system Terminal stage of cardiovascular, respiratory, renal or hepatic failure Grade IV malignancy Peripheral artery disease (PAD) of the lower extremities, any type of diabetes, or mental disease. Pregnant women at any gestational age, women who gave birth less than 12 months ago, and breastfeeding mothers.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>42 women (treated with Daflon 1000 mg (study group)) | Drug: Daflon<br>* All consecutive patients were randomly allocated into 2 groups to receive Daflon (Detralex) at a dose of 1000 mg once daily (study group) or placebo (control group).<br>|
| 2<br>41 women (placebo (control group)) | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pelvic Varicose Veins Questionnaire | Assessment of quality of life according to the questionnaire before and after treatment | 2 months |
Hemodilution and Coagulopathy With 3 Colloids

Study Overview
=================
Brief Summary
-----------------
Aim of this in vitro trial is to assess the effect on blood coagulation after 60 % dilution with different colloids (HES 130/0.42, Gelatin and Gelatin balanced) and investigate reversibility by replacement of fibrinogen (FBG), factor XIII (F XIII), and the combination of FBG and FXIII. In blood of 12 volunteers the following measurements are performed at baseline and 60% dilution with HES 130/0.42, Gelatin or Gelatin balanced: Blood gas analyses, coagulation factor concentrations (F II,F VII,F VIII,F XIII), impedance aggregometry and rotational thrombelastometry (ROTEM®). Then FBG, F XIII and a combination of both was added, in concentrations corresponding to 6 g FBG and 1250 IU F XIII in adults. ROTEM® measurements and determination of factor concentrations are again performed. Trial with medical device

Official Title
-----------------
Influence of Hemodilution on Coagulation, pH, Platelet Function, Laboratory Values and ROTEM in Volunteers Using HES 6%, Gelatine and Balanced Gelatine and the Reversal of Coagulopathy With F XIII and Fibrinogen

Conditions
-----------------
Dilutional Coagulopathy

Intervention / Treatment
-----------------
* Other: Induced Coagulopathy by HES (Tetraspan), Gelatin (Physiogel), Gelatin balanced (Physiogel balanced)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: signed informed consent from before blood withdrawal Exclusion criteria: known coagulation disorders, any form of anticoagulation therapy, use of acetyl-salicylic acid within the past five days, use of non-steroidal anti-inflammatory agents within the past 24 hours, known renal disease or plasma concentrations of aspartate aminotransferase (>50 U l -1) or alanine aminotransferase (>50 U l-1) patients incapable of understanding the German language

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Induced Coagulopathy by HES (Tetraspan), Gelatin (Physiogel), Gelatin balanced (Physiogel balanced)|Blood drawn from volunteers|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Reversibility of in vitro induced coagulopathy | Coagulopathy in vitro measured after 60 % dilution with HES, Gelatin and Gelatin balanced. Addition of fibrinogen and factor XIII as well as their combination and measurement if the coagulopathy was corrected. | Same day when blood was drawn |
Beneficial Effects of Microsurgical Varicocelectomy on Semen Parameters for Causes Other Than Infertility

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate whether clinical varicoceles are associated with abnormal semen parameters and whether varicocelectomy could improve the semen parameter in patients unrelated with infertility.

Detailed Description
-----------------
While most studies are continued to validate the observations of significant improvements in sperm density and motility after varicocele ligation in infertile patients, there have been few studies to investigate the effects of varicocelectomy on semen parameters in adult men unrelated with infertility. The purpose of this study was to determine whether varicocelectomy could improve the semen parameter of these patients as well as whether clinical varicoceles are associated with abnormal semen parameters in patients unrelated with infertility.

Official Title
-----------------
Beneficial Effects of Microsurgical Varicocelectomy on Semen Parameters in Patients Who Underwent Surgery for Causes Other Than Infertility

Conditions
-----------------
Varicocele

Intervention / Treatment
-----------------
* Procedure: Microsurgical subinguinal varicocelectomy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: men with clinical varicoceles underwent microsurgical varicocelectomy due to causes other than infertility such as testicular pain, discomfort or scrotal mass Exclusion Criteria: adolescents men with proven fertility or azoospermia men with preoperative normal sperm analysis available data to compare between preoperative and postoperative semen analyses

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| varicoceles<br>men with clinical varicoceles underwent microsurgical varicocelectomy due to causes other than infertility such as testicular pain, discomfort or scrotal mass | Procedure: Microsurgical subinguinal varicocelectomy<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sperm concentration, motility, and morphology | To observe the change of sperm concentration, motility, and morphology pre and postoperatively in the patients of inclusion criteria | at postoperative 4months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| whether semen analysis should be done in men with clinical varicocele regardless of the chief complaint | this result would show the need of performing semen analysis even in the patients with clinical varicocels due to causes other than infertility | at postoperative 4months |
Dose Ranging and Dose Frequency of LIPO-102

Study Overview
=================
Brief Summary
-----------------
Dose Ranging and Dose Frequency of LIPO-102

Official Title
-----------------
A Dose-Ranging and Dose Frequency Study Evaluating the Safety and Efficacy of LIPO-102 for the Reduction of Abdominal Subcutaneous Adipose Tissue

Conditions
-----------------
Subcutaneous Adipose Tissue Reduction

Intervention / Treatment
-----------------
* Drug: LIPO-102
* Drug: Placebo


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Male or non pregnant female Good general health Sufficient abdominal fat for injections Signed informed consent Exclusion Criteria: Known hypersensitivity to study drugs Treatment with an investigational agent within 30 days of first dose

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: LIPO-102<br>LIPO-102 | Drug: LIPO-102<br>* Subcutaneous Injection<br>|
| Experimental: Placebo<br>Placebo | Drug: Placebo<br>* Placebo<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Safety: physical examinations, laboratory tests, AE assessment |  | 4 weeks treatment and 4 weeks follow up | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Efficacy: change in subcutaneous abdominal adipose tissue thickness |  | 4 weeks treatment and 4 weeks follow up |
Moral Judgements and Choices of Caregivers in the Time of COVID-19 Pandemic

Study Overview
=================
Brief Summary
-----------------
The XPHI-COVID19 randomized study aims to investigate the mechanisms of moral judgements in a population of caregivers, using a survey, with the results to the Oxford Utilitarianism Scale as primary outcome.

Official Title
-----------------
Moral Judgements and Choices of Caregivers in the Time of COVID-19 Pandemic: a Randomized Experimental Study

Conditions
-----------------
Morals

Intervention / Treatment
-----------------
* Behavioral: Choices and judgements


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All caregivers from french public healthcare center with Intensive Care Unit Agreement Exclusion Criteria: Refuse to participate or withdraw agreement

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 99 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Choices then judgements<br> | |
| Active Comparator: Judgements then choices<br>Switch in the order of clinical cases in the survey | Behavioral: Choices and judgements<br>* In the intervention arm, the participant is asked to answer clinical cases in a reverse order from the control group (control has to make moral choices then judge somebody else's choices ; intervention has to judge moral choices first, then make his own)<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Oxford Utilitarianism Scale | Two-Dimensional Model of Utilitarian Psychology | Up to one year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
morals, ethics, moral judgements, moral choices, covid 19, survey, utilitarianism, deontology, oxford utilitarianism scale
Evaluation of Feconomics for Diagnosis of Intestinal Parasitic Infections

Study Overview
=================
Brief Summary
-----------------
People of all ages are affected by intestinal parasitic infections(IPIs) ; however, children are the most commonly affected, which is linked to their poor hygienic practices, and weak immune status. In children, IPIs are associated with malabsorption, weight loss, anemia, poor growth rate, learning difficulties, mental retardation and intellectual problems . The difficulty of diagnosis is the main problem in the control of intestinal parasitic infections. The choice of a particular technique is usually influenced by affordability, simplicity, cost, sensitivity in addition to the level of technical skills involved. Microscopic examination remains the cornerstone of parasitological diagnosis which is time consuming and requires an experienced observer to identify the organism. Formalin-ether sedimentation technique is commonly used in laboratories owing to its ability to isolate a large variety of parasites. However, it's a labor intensive procedure and is usually associated with hazards of using the inflammable lipid solvents. The drawbacks of the previous techniques have encouraged the development of commercial products such as Feconomics which is a new ready to use kit for concentration of stool samples in parasitological diagnosis. The aim of the study is : evaluation of the efficacy of Feconomics technique in comparison to traditional techniques i.e., direct smear and formalin ethyl acetate sedimentation technique for the diagnosis of intestinal parasites in school children.

Official Title
-----------------
Evaluation of Feconomics Versus Traditional Techniques for Diagnosis of Intestinal Parasitic Infections

Conditions
-----------------
Intestinal Parasitic Infection

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: school children whose age is between 6-12 years Exclusion Criteria: children taking anti-parasitic drugs within the previous two weeks of stool sample collection .

Ages Eligible for Study
-----------------
Minimum Age: 6 Years
Maximum Age: 12 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluation of the efficacy of Feconomics technique which is a new ready to use kit for concentration of stool samples , for diagnosis of intestinal parasitic infections in children | Comparing the sensitivity and specificity with traditional techniques i.e., direct smear and formalin ethyl acetate sedimentation technique for diagnosis of intestinal parasitic infections by examining stool samples from 100 patients, the number of cases with any intestinal parasite will be recorded. | 6 months following the startpoint of the study |
SVC Occlusion in Subjects With Acute Decompensated Heart Failure

Study Overview
=================
Brief Summary
-----------------
Safety and performance evaluation of the preCARDIA System for patients with ADHF.

Detailed Description
-----------------
The objective of this early feasibility study is to evaluate the safety and performance of the preCARDIA System for Superior Vena Caval (SVC) intermittent mechanical occlusion as a therapeutic approach in significantly congested subjects with Acute Decompensated Heart Failure (ADHF), who are not diuresing adequately.

Official Title
-----------------
Superior Vena Caval Occlusion in Subjects With Acute Decompensated Heart Failure

Conditions
-----------------
Acute Decompensated Heart Failure, Acute Heart Failure, Congestive Heart Failure, Heart Diseases

Intervention / Treatment
-----------------
* Device: preCARDIA system


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: NYHA Class III-IV heart failure Subjects with inadequate diuresis Stage C-D systolic heart failure Exclusion Criteria: Active myocardial ischemia or acute coronary syndrome (ACS) Severe aortic or mitral valve insufficiency Severe peripheral vascular disease

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Device Feasibility
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: ADHF Patients<br>Treatment with preCARDIA System | Device: preCARDIA system<br>* Intermittent occlusion of the SVC<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Freedom from Major Adverse Events through 90 days post-discharge. | MAE is defined as death, myocardial infarction, major thromboembolic event, vascular damage requiring surgical intervention, hemorrhagic stroke or prolongation of heart failure- related hospitalization attributable to the preCARDIA device or procedure. | 90 days post-discharge |
Evaluation of Intra Axial Brain Masses Based on Magnetic Resonance in Adults

Study Overview
=================
Brief Summary
-----------------
Although the Magnetic resonance imaging with contrast is the gold standard for diagnosis of intra axial brain masses. The conventional Magnetic resonance imaging appearances of intra axial brain masses can be non-specific and even the use of contrast agent is of limited benefit. Contrast enhancement reflects only disruption of blood brain barrier. One third of high-grade malignancies are non-enhanced and may non-neoplastic lesions show contrast enhancement. Reliable differentiation of neoplastic from non-neoplastic brain masses, or of high grade from low grade tumor, is difficult with conventional Magnetic resonance imaging

Official Title
-----------------
Impact of Advanced Neuroimaging Techniques in Evaluation of Intra Axial Brain Masses Based on Magnetic Resonance Diagnostic Strategy in Adults

Conditions
-----------------
Brain Tumor

Intervention / Treatment
-----------------
* Device: Magnetic resonance imaging with contrast


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: * An intra axial space occupying lesion/lesions detected on conventional structural imaging Exclusion criteria: MRI contraindications (as pace maker or claustrophobia). Contrast hypersensitivity Impaired renal function. Pediatric age group

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: Magnetic resonance imaging with contrast|injection of gadolinium contrast then acquisition of images with magnetic resonance imaging then spectroscopy|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patients with malignant masses | sensitivity of the magnetic resonance spectroscopy in diagnosis of brain malignant masses | 1 hour |
The Effect of Square Dance on Rheumatoid Arthritis

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to observe the effect of square dance on rheumatoid arthritis.

Conditions
-----------------
Rheumatoid Arthritis

Intervention / Treatment
-----------------
* Other: SQ
* Other: Control


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: had wrist and/or MCP involvement aged 18 years diagnosed by rheumatology consultants with RA Exclusion Criteria: severe psychological difficulties currently receiving mental health care any medical condition that might prevent them from safely exercising (e.g. history of more severe heart, lung or cerebrovascular disease) previously attended an education programme had a Modified Health Assessment Questionnaire score above 2 (0-3)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: SQ<br>Patients with rheumatoid arthritis exercise square dance | Other: SQ<br> <br> Other: Control<br> <br> |
| Sham Comparator: Control<br>Patients with rheumatoid arthritis listen to accompany music of square dance at home | Other: SQ<br> <br> Other: Control<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes from baseline Arthritis Helplessness Index (AHI) at 24 weeks |  | At 0 week, 12 weeks, 24 weeks |