Development of a Musculoskeletal Model of the PIP Joint

Study Overview
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Brief Summary
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The proximal interphalangeal (PIP) joint is the second joint in the finger from the finger tip. The outcome following replacement surgery of this joint is considered unsatisfactory. In order to improve these outcomes, it would be helpful to understand the geometry of the joint, how it moves and the forces that are involved. This can be achieved using computer models that model the bones and the soft tissues - musculoskeletal models. In order to make these models as representative as possible, they should be generated using anatomical data. Data will initially be extracted from patients' existing magnetic resonance imaging (MRI) and computed tomography (CT) scans. This will enable the computer model to begin being constructed. In parallel to the model initialisation, anatomical and motion data of the PIP joint of healthy volunteers will be collected. The necessary data will be collected using CT and MRI scans, as well as optical motion tracking methods. These data will then be used to populate the musculoskeletal model. Once the model is constructed, it will be used to simulate the motion of the joint and look at the effect of a simulated PIP joint replacement. This information should then provide insight as to how PIP joint replacements might be improved in future.

Official Title
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Development of Parametric Musculoskeletal Models to Investigate the Anatomy and the Function of the PIP

Conditions
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Patient Specific Computational Modeling

Intervention / Treatment
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* Other: Motion capture
* Diagnostic Test: MR scan
* Diagnostic Test: CT scan


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: In general good health University of Southampton members of staff Over 18 years old and able to provide informed consent No known problems relating to the PIP joint Exclusion Criteria: Volunteers involved in other studies concerned with the function and anatomy of the PIP joint which would have adverse effects on this study and/or the study in which they are currently involved. Those undergoing treatment related to the PIP joint No metallic object should be present in the scanner and therefore those with any implanted metallic devices, or other devices which may cause or be caused adverse effects (e.g. metal plate, pacemaker)

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Motion capture, MR scan, CT scan<br>All volunteers will go through the same data collection process | Other: Motion capture<br>* Capture kinematics of finger movements<br>Diagnostic Test: MR scan<br>* Capture MR images of hand and fingers in three postures<br>Diagnostic Test: CT scan<br>* Capture CT images of hand and fingers in three postures<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Capturing hand kinematics using Vicon optical motion capture | Capture hand kinematics of 10 healthy volunteers | 3 years | 
| Capturing images of the soft tissue in the hand using MR imaging | Capture MR images of the hand for same 10 healthy volunteers as Outcome 1 | 3 years | 
| Capturing images of the bony structures in the hand using CT scanning | Capture CT images of the hand for same 10 healthy volunteers as Outcome 1 | 3 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Kinematics, MRI Scans, CT Scan, Single-Photon Emission, finger interphalangeal joint