Evaluation of Pediatric Measles Cases in 2019: Single-Center Experience

Study Overview
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Brief Summary
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Measles, can be prevented and eliminated by vaccination, is a highly contagious viral disease that can lead to serious complications, disability, and death. As a result of the World Health Organization (WHO) and United Nations International Children's Emergency Fund (UNICEF) strategic plans, the annual global incidence of measles decreased by 75% over the period 2000-2015, and the estimated global mortality rate fell by 73%. For the current 2019 period, the European and the Eastern Mediterranean Region has recorded respectively more than two-fold and 1.5-fold increase in reported measles cases. As it is known, no specific antiviral treatment exists for the measles virus therefore, vaccination is still the most effective method of preventing disease. The aim of this study was to evaluate the measles cases in districts where the refugees live quite intensely.

Detailed Description
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Measles, can be prevented and eliminated by vaccination, is a highly contagious viral disease that can lead to serious complications, disability, and death. As a result of the World Health Organization (WHO) and United Nations International Children's Emergency Fund (UNICEF) strategic plans, the annual global incidence of measles decreased by 75% over the period 2000-2015, and the estimated global mortality rate fell by 73%. For the current 2019 period, the European and the Eastern Mediterranean Region has recorded respectively more than two-fold and 1.5-fold increase in reported measles cases. As it is known, no specific antiviral treatment exists for the measles virus therefore, vaccination is still the most effective method of preventing disease. The aim of this study was to evaluate the measles cases in districts where the refugees live quite intensely. This retrospective study was consecutively enrolled children who were considered as suspicious measles case according to with clinical features and attended in Esenler Gynecology and Pediatrics Hospital Pediatric Clinic between 01 January-30 June 2019.

Official Title
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Evaluation of Pediatric Measles Cases in 2019: Single-Center Experience

Conditions
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Measles

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: The suspicious case of measles Measles/Rubella Case Notification and Laboratory request and result form and Measles/ Rubella Case Study form must be filled Accept the informed consent form Positive Measles Ig M and Measles Ig G laboratory test Exclusion Criteria: Rejected the informed consent form

Ages Eligible for Study
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Minimum Age: 1 Month
Maximum Age: 18 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluate the effect of measles vaccination status on symptom duration | compare the groups symptom durations (day) who fully, partly or not vaccinated | baseline | 
| Evaluate the effect of vitamin A treatment on symptom duration | compare the groups symptom durations (day) who get or not get vitamin A treatment | in the first month after the first symptom observed | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluate the effect of measles vaccination status on leucocyte count | compare the groups leucocyte count who fully, partly or not vaccinated | baseline | 
| Evaluate the effect of vitamin A treatment on leucocyte count | compare the groups leucocyte count who get or not get vitamin A treatment | baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Children, Vaccine, Vitamin A, Measles