Arithmetic Abilities in Children With 22q11.2DS

Study Overview
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Brief Summary
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The study ARITH22 will investigate the role of visuo-spatial attention on arithmetic abilities of children with 22q11.2 deletion syndrome.

Detailed Description
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Children with 22q11.2 deletion syndrome often have arithmetic learning disability because of magnitude representation impairment. Previous works suggested that magnitude representation impairment could be a result of endogenous visuo-spatial attention dysfunction in 22q11.2DS. Nevertheless this relationship is still poor explored. The influence of visuo-spatial abilities on arithmetic achievement could also be modulated by developmental age. The study ARITH22 will test these hypotheses thanks to magnitude comparisons tasks, in children with 22q11.2 deletion syndrome and matched children without developmental disease.

Official Title
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Study of Arithmetic Abilities of Children With 22q11.2 Deletion Syndrome Aged From 4 to 11 Years Old

Conditions
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22q11.2 Deletion Syndrome

Intervention / Treatment
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* Behavioral: Magnitude comparison tasks and neuropsychological testing


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosis of 22q11.2 deletion syndrome or no developmental disease Aged from 4 to 11 years old French language Exclusion Criteria: Diagnosis of intellectual deficiency according to DSM 5 criteria Drug prescribed for somatic condition that could influence cerebral functioning

Ages Eligible for Study
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Minimum Age: 4 Years
Maximum Age: 11 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Monocentric study with two parallel groups
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 22q11.2DS<br>Children aged from 4 to 11 years old with 22q11.2 deletion syndrome | Behavioral: Magnitude comparison tasks and neuropsychological testing<br>* neuropsychological testing (ZAREKI-R) and magnitude comparison tasks with stimuli of different types (visual, visuo-spatial)<br>|
| Active Comparator: NON22q11.2DS<br>Children aged from 4 to 11 years old without developmental disease | Behavioral: Magnitude comparison tasks and neuropsychological testing<br>* neuropsychological testing (ZAREKI-R) and magnitude comparison tasks with stimuli of different types (visual, visuo-spatial)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percentage of impaired scaled score | percentage of impaired scaled score at ZAREKI-R | single day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percentage of correct responses | percentage of correct responses in magnitude comparisons tasks | single day | 
| Mean reaction time | mean reaction time in magnitude comparison tasks | single day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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children, 22q11.2 deletion syndrome, arithmetic, magnitude representation