Adipogenic Capacity as a Mediator of Weight Gain

Study Overview
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Brief Summary
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To demonstrate differences in response of subjects with a high, low or medium predisposition for weight regain after weight reduction in terms of: body composition; energy expenditure; physical activity; and adipogenic capacity.

Detailed Description
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The risk for weight regain after weight loss is a major problem for the current obesity treatments, and is largely genetically determined. It is believed that an elucidation of the genetic component in the prognosis of weight management could assist in the development of more effective and individually tailored treatments. However, current research on the genetic component of weight management, and in particular weight regain, is still limited and data available are sometimes inconsistent. The current research proposal aims to identify groups with a high, low or medium predisposition for weight regain, based on a genetic profile and to demonstrate differences in the response of these subjects to a weight maintenance period after weight reduction in terms of body composition, physical activity, adipogenic capacity and energy expenditure.

Official Title
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The Role of the Genetic Background Involved in Weight Regain Through Mechanisms Including Energy Expenditure, Physical Activity and Adipogenic Capacity

Conditions
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Obesity

Intervention / Treatment
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* Other: Very Low Energy Diet (VLED)
* Other: Weight maintenance


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: BMI 28-35 healthy, no medication no smoking stable weight (no weight loss/gain > 5kg in 3 months prior to study) Exclusion Criteria: 28< BMI >35 use of medication smoking weight loss/gain > 5kg in 3 months prior to study

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: High predisposition<br>High predisposition for weight regain | Other: Very Low Energy Diet (VLED)<br>* a VLED (Modifast) for 2 months in order to reduce body weight<br>* Other names: Modifast;Other: Weight maintenance<br>* 10 months<br>|
| Other: low predisposition<br>low predisposition for weight regain | Other: Very Low Energy Diet (VLED)<br>* a VLED (Modifast) for 2 months in order to reduce body weight<br>* Other names: Modifast;Other: Weight maintenance<br>* 10 months<br>|
| Other: Medium predisposition<br>Medium predisposition for weight regain | Other: Very Low Energy Diet (VLED)<br>* a VLED (Modifast) for 2 months in order to reduce body weight<br>* Other names: Modifast;Other: Weight maintenance<br>* 10 months<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Energy expenditure |  | 0, 2 and 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Adipogenic capacity, Physical activity and body composition |  | 0, 2 and 12 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Weight loss and maintenance, body composition, energy expenditure, adipogenic capacity, physical activity