Taurine as a Possible Anti-aging Therapy?

Study Overview
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Brief Summary
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Among the strategies that can improve the body's ability to counteract oxidative stress, the use of nutritional antioxidants has been investigated. Taurine is a semi-essential amino acid, also called a nitrogen compound, which has been used as an effective antioxidant due to its ability to neutralize hypochlorous acid, an extremely toxic oxidant produced by leukocytes in the inflammatory process in humans.

Detailed Description
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Objective: To evaluate the oxidative parameters of women aged 55 to 70 years after 16 weeks of taurine supplementation. Methods: Twenty-four women age 55 to 70 will be randomly assigned to two groups: control group (GC), supplemented with placebo (1.5 g of starch); and taurine group (GTAU), supplemented with taurine (1.5 g), for 16 weeks. Anthropometry, functional capacity test, taurine, and levels of oxidative stress markers will be determined in pre and post intervention plasma samples. Food consumption will be assessed before, during, and after the intervention. The results will be analyzed by an ANOVA two-way repeated measures mixed model, with the Sidak post hoc (p < 0.05).

Official Title
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Taurine as a Possible Anti-aging Therapy? A Controlled Clinical Trial on Taurine Antioxidant Activity in Women Aged 55 to 70 Years

Conditions
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Oxidative Stress

Intervention / Treatment
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* Dietary Supplement: Taurine
* Dietary Supplement: Placebo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Had being aged 55-70 years; Female; Post-menopausal; Sedentary (not practicing physical exercise for at least 6 months). Exclusion Criteria: Chronic kidney diseases; Infectious contagious diseases; Coronary heart disease; Smokers Alcoholics.

Ages Eligible for Study
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Minimum Age: 55 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Double-blind placebo controlled study
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Taurine supplementation<br>Taurine supplementation composed of capsules of taurine powder. Dosage: 1.5 gram/day Frequency: 1 time/day Duration: 16 weeks | Dietary Supplement: Taurine<br>* Taurine supplementation in capsules of 500 grams of taurine powder, total dosage: 1.5 gram/day<br>* Other names: Taurine supplementation in capsules of 500 grams of taurine powder, total dosage: 1.5 grams/day;|
| Placebo Comparator: Placebo supplementation<br>Placebo supplementation composed of capsules of starch powder. Dosage: 1.5 gram/day Frequency: 1 time/day Duration: 16 weeks | Dietary Supplement: Placebo<br>* Placebo supplementation in capsules of 500 grams of starch powder, total dosage: 1.5 gram/day<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from baseline in blood oxidative stress marker measurement - Superoxide Dismutase (SOD). | The superoxide dismutase (SOD) activity in erythrocytes was evaluated by the spectrophotometric method, and were calculated at 16 weeks in comparision to the baseline. | sixteen weeks | 
| Change from baseline in blood oxidative stress marker measurement - Glutathione reductase (GR). | Glutathione reductase (GR) activity was determined by the spectrophotometric method at 37 ºC/340nm after the oxidation of NADPH in the presence of oxidized glutathione, and were calculated at 16 weeks in comparision to the baseline. | sixteen weeks | 
| Change from baseline in blood oxidative stress marker measurement - Malondialdehyde (MDA). | The malondialdehyde (MDA) were calculated at 16 weeks in comparision to the baseline. | sixteen weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Therapeutic Strategy, Aging, Oxidative Stress, Taurine, Nutritional Supplementation