Effect of Anesthetics on Microcirculation in Patients Undergoing Off-pump Coronary Artery Bypass Surgery

Study Overview
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Brief Summary
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Volatile anesthetics, such as sevoflurane and desflurane, are commonly used in patients undergoing cardiac surgeries including off-pump coronary artery bypass. However, the effect of volatile anesthetics on microcirculation in patients undergoing off-pump coronary artery bypass has not been well conducted.

Detailed Description
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This is a prospective randomized clinical trial investigating the effect of sevoflurane vs. desflurane on tissue microcirculation in patients undergoing off-pump coronary artery bypass surgery. Eligible patients are going to be randomized to receive sevoflurane or desflurane, as a maintenance anesthetic, during the surgery. Tissue oxygen saturation and microcirculatory changes, such as an occlusion and recovery slope, during vascular occlusion test will be recorded during the surgery. The primary end point of the study is the difference in tissue oxygen saturation between the groups.

Official Title
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Effect of Anesthetics on Microcirculation in Patients Undergoing Off-pump Coronary Artery Bypass Surgery

Conditions
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Microcirculation, Anesthetic Complication Spinal

Intervention / Treatment
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* Drug: Sevoflurane
* Drug: Desflurane


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: scheduled for off-pump coronary artery bypass surgery Exclusion Criteria: any deformity or vascular abnormalities on upper arms cannot receive sevoflurane or desflurane for any reason (muscular diseases, etc) uncontrolled diabetes peripheral vascular disease severe renal dysfunction (end-stage renal disease) refuse to enroll pregnant

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Sevoflurane<br>Sevoflurane (2 vol%) use as a maintenance volatile anesthetic drug during the surgery | Drug: Sevoflurane<br>* Sevoflurane use as main anesthetic drug during the surgery<br>|
| Experimental: Desflurane<br>Desflurane (6 vol%) use as a maintenance volatile anesthetic drug during the surgery | Drug: Desflurane<br>* Desflurane use as main anesthetic drug during the surgery<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Tissue oxygen saturation measured at thenar eminence by Hutchinson(R) tissue oximeter during off-pump coronary artery bypass surgery | Tissue oxygen saturation measured at thenar eminence by tissue oximeter during surgery in patients receiving sevoflurane or desflurane | Before induction of anesthesia to the end of the surgery, an average 8 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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sevoflurane, off-pump coronary artery bypass, desflurane, tissue oxygen saturation