Development, Implementation and Initiation of Normative Database Quantitative Ultra High Field MRI Paramaters

Study Overview
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Brief Summary
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The Centre for Magnetic Resonance in Biology and Medicine (CRMBM, UMR-CNRS 7339 AMU) obtained funding for a whole body NMR imaging at 7. It is the only MRI at 7T installed in a hospital in France (only two 7T MRI in France) and therefore a unique opportunity to develop new diagnostic approaches. The purpose of this study is to develop, implement and validate new MRI quantitative parameters derived from ultra high field MRI in order to characterize non-invasively with an unprecedented resolution and sensitivity, anatomy as well as certain physiological, hemodynamic and metabolic function of brain, spinal cord, musculoskeletal system, and heart in healthy subjects

Detailed Description
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The key is that the goal of our projects is not only producing images of better quality than using a 3T scanner but also making images differently, by highlighting new contrasts and features of theses organs in order to improve the diagnosis and prognosis of neurological, psychiatric, cardiovascular and rheumatologic diseases.

Official Title
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Development, Implementation and Initiation of Normative Database Quantitative Ultra High Field MRI Paramaters

Conditions
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Healthy

Intervention / Treatment
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* Procedure: acquisition of normative database with ultra high field MRI
* Device: MRI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: People not presenting contraindications to the MRI (pacemaker, agitation, metallic brightness, claustrophobia etc.) People having no intra-physical object potentially conductive. People having no affection after detailed interrogation Exclusion Criteria: People staying in a sanitary or social establishment People in emergency situation People not wishing to be informed about anomalies in the MRI Pregnancy

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Acquisition of normative database<br>Development, implementation and initiation of normative database (image and data) quantitative ultra high field MRI paramaters | Procedure: acquisition of normative database with ultra high field MRI<br>* characterize non-invasively with an unprecedented resolution and sensitivity (high field MRI), anatomy as well as certain physiological, hemodynamic and metabolic function of brain, spinal cord, musculoskeletal system, and heart<br>Device: MRI<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| qualitative validation concerning structure visible with high field MRI | the validation criteria are qualitative (contrast and visibility of anatomical structures usually visible 7T but not visible at 3T will be used to assess the sensitivity of images for each modality) and quantitative (signal to noise ratio (SNR), spatial and temporal resolution). | 4 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| acquisition of normative data and verification of the quality criteria obtained during the first phase | During the second phase, we will acquire normative data and verify the quality criteria of the first phase. Each quantitative variable will be extracted. After the acquisition of the first 30 volunteers for each parameter, the variance will be analyzed to assess the population distribution. Depending on the results, and issues raised by clinical research studies, other populations will be acquired | 4 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Volunteers