linjc16/ctgov huggingface dataset:
Normal Prostate: Oxygenation of the Prostate Gland in Men Undergoing Prostate Biopsy

Study Overview
=================
Brief Summary
-----------------
This study is based on previous observation that, in men with localized prostate cancer, non-cancerous prostate tissue is hypoxic, and on the known contribution of hypoxia to the progression of cancer. Patients undergoing diagnostic prostate biopsy with serum prostate specific antigen (PSA) less than 10ng/ml and who have given informed consent will have oxygen measurements of the prostate and peri-prostatic tissue taken with the Eppendorf electrode at the time of biopsy. The oxygenation of normal prostate tissue will be compared to that of cancerous prostate tissue. In men with negative biopsies, the prostate tissue oxygen measurements will be compared with the peri-prostatic tissue oxygen measurements.

Official Title
-----------------
Oxygenation of the Prostate Gland: a Polarographic Electrode Study in Men Undergoing Prostate Biopsy.

Conditions
-----------------
Prostatic Neoplasms

Intervention / Treatment
-----------------
* Procedure: Oxygen measurement - Eppendorf machine


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Men due to undergo sextant prostate biopsy Serum PSA <10 ng/ml Exclusion Criteria: Previous diagnosis of prostate cancer Inability to give informed consent

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Oxygen measurement - Eppendorf machine|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Median pO2 and HP5 will be analyzed according to the presence or absence of tumour on biopsy |  | 7 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Median pO2 and HP5 for the prostate gland in each patient with negative biopsy result will be compared with the median pO2 and HP5 for peri-prostatic tissue. |  | 7 years |
The Applications and Influences of Transthoracic Echocardiography in Stroke Patients

Study Overview
=================
Brief Summary
-----------------
Transthoracic echocardiography (TTE) is known to be an effective modality in assessing cardiac function as well as the structure of the heart. It was estimated that between 15% and 30% of ischemic strokes were due to a cardioembolic source, Therefore, TTE has been assumed as an important screening tool in patients with ischemic stroke, as atrial fibrillation is one of the leading risk factors. However, current guidelines have little evidence in whether performing TTE can alter clinical management and prevent a future stroke. We aim to present the association of performing TTE and clinical outcomes in stroke patients.

Official Title
-----------------
The Applications and Influences of Transthoracic Echocardiography in Stroke Patients

Conditions
-----------------
the Impact of Echocardiography on the Recurrence of Stroke

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients with acute stroke and receiving echocardiography Exclusion Criteria: patients with acute stroke and not receiving echocardiography

Ages Eligible for Study
-----------------
Minimum Age: 20 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| recurrent stroke | the correlation between the echocardiography and recurrence of stroke | one year |
Effect of Dexmedetomidine on QT Interval in Pediatric Patients Under General Anesthesia

Study Overview
=================
Brief Summary
-----------------
Various medications used in anesthesia have been implicated in the prolongation of QT interval. Recently, there has been an increase in the use of dexmedetomidine in patients presenting for surgeries given its beneficial sedative, anxiolytic, and analgesic properties. It has several desirable properties including minimal respiratory side effects as well as the ability to decrease intraoperative and postoperative analgesic requirements. In many of the patients who present for routine surgical procedures, dexmedetomidine is a common component of their anesthetic care. This is a study to assess the effects of dexmedetomidine on the QT interval in children presenting for surgery.

Conditions
-----------------
Surgery

Intervention / Treatment
-----------------
* Device: ECG


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: ASA grade 1 or 2. Scheduled to receive dexmedetomidine. Exclusion Criteria: Known allergy to dexmedetomidine.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Dexmedetomidine patients<br>Surgical patients receiving dexmedetomidine. | Device: ECG<br> <br> |
| Control patients<br>Surgical patients not receiving dexmedetomidine. | Device: ECG<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in QT interval | ECG will be done to assess QT interval prior to induction (baseline), after induction (5 mins.) and after dexmedetomidine (10 mins.) | Baseline, 5 mins., 10 mins. |
ICU Cell Saver to Reduce Blood Transfusions in Cardiac

Study Overview
=================
Brief Summary
-----------------
PURPOSE: Autotransfusion devices may be employed in cardiac surgery to decrease allogenic blood requirements. Limitations of previous trials include the use of cell saver systems in selected high risk patients only or the lack of blood transfusion-sparing strategies. The aim of this prospective randomized study is to evaluate the efficacy of cell salvage CardioPAT routinely used in cardiac surgery. METHODS: The investigators will randomize 350 patients in two groups: group 1 receives a CardioPAT cell saver device (175 patients), group 2 doesn't receive any cell saver device. The incidence of allogenic blood transfusion and clinical outcome in both groups are evaluated.

Official Title
-----------------
Routinely Use of CardioPAT Cell Saver in Cardiac Surgery: A Prospective Randomized Study Focused on Allogenic Blood Transfusion and Clinical Outcome

Conditions
-----------------
Blood Transfusion, Cardiac Surgery

Intervention / Treatment
-----------------
* Device: CARDIOPAT
* Device: Traditional Chest Drains


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All patients presenting for cardiac Surgery Exclusion Criteria: None
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Control<br>Traditional Chest drains | Device: Traditional Chest Drains<br>* Chest drains as usual with no possibility to reinfuse lost blood<br>|
| Experimental: CARDIOPAT<br>CARDIOPAT Cell Saver after Surgery | Device: CARDIOPAT<br>* Cell Saver System at bedside for ICU stay<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of Transfusions per patient |  | 10 days after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality |  | 30 days after surgery | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Blood Transfusion, Cell Saver, Cardiac Surgery, Evaluate the efficacy of cell salvage CardioPAT routinely used in cardiac surgery in reducing blood transfusions.
Lung Function and Airway Inflammation in Portland Cement Workers

Study Overview
=================
Brief Summary
-----------------
The aim of the study is to examine inflammation in the airways and in peripheral blood, in workers in a cement plant i Norway.

Detailed Description
-----------------
OBJECTIVE: Former studies have presented conflicting data on the association between exposure to Portland cement dust and respiratory effects. Our goal is to examine inflammation in the airways and in peripheral blood in subjects exposed to cement-dust. METHODS: All non smoking, dust exposed, workers from one department in the largest cement plant in Norway, are invited to participate. The workers will perform spirometry and induced sputum (IS) after a period of regular work with cement dust exposure, and again after a minimum of 5 days without exposure. Information on respiratory symptoms, allergy and former respiratory disease will be given on a self-reported questionnaire. IS was performed and processed as described by Pin et al. Differential cell counts will be carried out. Inflammatory markers in induced sputum and in peripheral blood will be measured. We want to use a crossover design were the cases are used as their own controls, but we will also include external controls.

Official Title
-----------------
Airway Inflammation in Cement Dust Exposed Workers

Conditions
-----------------
Airway Inflammation, Peripheral Blood Inflammation Markers, Cement Dust Exposure

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Cement dust exposure Non-smoker or ex-smoker >3 years Exclusion Criteria: Infectious disease during the last 3 weeks Chronic airway disease

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 67 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percentage of neutrophile cells in induced sputum | A significantly higher percentage of neutrophils was observed in induced sputum samples from cement production workers collected during an exposed period compared with a nonexposed period and compared with external controls. | Before and after a period of exposure | 
| Concentration of Interleukin 1beta in induced sputum | The concentration of Interleukin 1beta was higher in the sputum of workers during an exposed period than that of the office workers or the external controls. | Before and after a period of exposure to cement production dust | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Cement dust exposure, Induced sputum, Airway inflammation, Peripheral blood inflammation markers
Short-Term Alpha Lipoic Acid Therapy for Prevention of Contrast-induced Acute Kidney Injury and Endothelial Dysfunction in Type 2 Diabetes

Study Overview
=================
Brief Summary
-----------------
Contrast-induced acute kidney injury (CIAKI) is a major complication with adverse outcomes after contrast media injection. Although the risk of developing CIAKI is low in patients with normal renal function, it is dramatically higher in patients with conditions such as diabetes mellitus (DM) or chronic kidney disease (CKD). More recently, our data showed that contrast agents can induce endothelial dysfunction partially via free radicals in diabetes. Therefore, strategies to prevent CIAKI and endothelial dysfunction in DM patients with CKD are urgently needed. Alpha-lipoic acid and its reduced form, dihydrolipoate, are potent antioxidants. We hypothesized that alpha lipoic acid can prevent the contrast-induced acute kidney injury and endothelial dysfunction in type 2 diabetes.

Official Title
-----------------
Short-Term Alpha Lipoic Acid Therapy for Prevention of Contrast-induced Acute Kidney Injury and Endothelial Dysfunction in Type 2 Diabetes

Conditions
-----------------
Acute Kidney Injury, The Changes of Plasma Creatinine, The Changes of Plasma Free Radicals, The Changes of Endothelium-dependent Arterial Dilation

Intervention / Treatment
-----------------
* Drug: Alpha lipoic acid


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: type 2 diabetes nephropathy (stage 3 and 4) Exclusion Criteria: recive alpha lipoic acid type 1 diabetes nephropathy (stagte 1, 2 and 5) hypersensitivity to contrast media IV heart failure lactic acidosis

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: alpha-lipoic acid group<br>Alpha lipoic acid 600 mg in 0.9% sodium chloride 250 ml was given before and after contrast agent was administrated. | Drug: Alpha lipoic acid<br> <br> |
| Placebo Comparator: Placebo intervention group<br>Only 0.9% sodium chloride 250 ml was given for this group. | Drug: Alpha lipoic acid<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Contrast induced acte kidney injury |  | 6 months | 
| The changes of endothelium-dependent arterial dilation before and after contrast administrated |  | 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Type 2 diabetes, Nephropathy, Contrast medium, Alpha lipoic acid
The Effect of Fat on Vitamin D Absorption

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate the absorption of dietary supplement of vitamin D3 (cholecalciferol), through the variation of 25 (OH) D levels, as the fat content of the meal associated with the administration of the supplement.

Official Title
-----------------
The Effect of Fat on Vitamin D Absorption After a Single Oral Dose

Conditions
-----------------
Vitamin D Deficiency

Intervention / Treatment
-----------------
* Dietary Supplement: Vitamin D3
* Dietary Supplement: Placebo


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Residents of the hospital clinics of Porto Alegre Exclusion Criteria: Don't drink milk Obesity Malnutrition Liver disease Kidney disease or diabetes Use of dietary supplements containing calcium and vitamin D Medications Anticonvulsants Barbiturates, or steroids. Having performed a journey the last four months to locations near the Earth's equatorial plane, due to sun exposure that may have occurred during this period, or vacations planned during the study period.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Low fat Meal<br>50,000 UI vitamin D3 with low fat meal | Dietary Supplement: Vitamin D3<br>* Supplement of vitamin D3<br>Dietary Supplement: Placebo<br>* Placebo<br>|
| Experimental: Medium fat meal<br>50,000 UI vitamin D3 with medium fat meal | Dietary Supplement: Vitamin D3<br>* Supplement of vitamin D3<br>Dietary Supplement: Placebo<br>* Placebo<br>|
| Experimental: High fat meal<br>50,000 UI vitamin D3 with high fat meal | Dietary Supplement: Vitamin D3<br>* Supplement of vitamin D3<br>Dietary Supplement: Placebo<br>* Placebo<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from baseline in serum 25(OH)D at 14 day after intervention | 25(OH)D response to supplemental vitamin D3 | Change from baseline in serum 25(OH)D at 14 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from baseline in Parathyroid hormone at 14 days after intervention | Parathyroid hormone response to supplemental vitamin D3 | Change from baseline in Parathyroid hormone at 14 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Vitamin D, Cholecalciferol, Supplementation, Dietary Supplements, Dietary Fats, 25-hydroxyvitamin D
Quantitative Evaluation of Muscle Tone Using Elastic Ultrasound

Study Overview
=================
Brief Summary
-----------------
The test subjects were selected from patients with clinical manifestations in muscle tone and healthy volunteers. Elbow flexor is the main target muscle. Fifty patients and 50 healthy subjects were given three assessment methods to measure muscle tension: modified Ashworth rating scale, elastic ultrasound technology and surface electromyography, and the data obtained by these three methods will be statistically analyzed and discussed.

Official Title
-----------------
Study on Quantitative Evaluation of Muscle Tone Using Elastic Ultrasound

Conditions
-----------------
Muscle Tone Increased, Ultrasonography

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: There are clinical manifestations of changes in muscle tension of the elbow flexor group; Subject's diagnosis is clear; The degree of joint mobility meets the method of muscle tension assessment. Exclusion Criteria: Has serious diseases such as heart, lung, liver, kidney, etc., cardiac function grade is greater than Grade I (NYHA), has symptoms and signs or examination results such as respiratory failure; History of muscle disorders; Recent (within 6 months) history of external injury, fracture or surgery of the limb; Are using drugs that affect muscle tone; Severe osteoporosis; Acute phase of inflammation Acute limb thrombosis of the subject; Pregnancy.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| patients<br>patients with clinical presentions of change in muscle tone | |
| volunteers<br>healthy volunteers with normal muscle tone | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Modified Ashworth Scale | Modified Ashworth Scale of the target muscles | through study completion, an average of 1 year | 
| shear wave elastography | use shear wave elastography to evaluate Young's modules of target muscles at each angle of the joint during the passive movement | through study completion, an average of 1 year | 
| surface electromyography | use surface electromyography to evaluate average EMG, integrated electromyogram and root mean square of the target muscles | through study completion, an average of 1 year |
Khon Kaen University's Thyroidectomy Registry

Study Overview
=================
Brief Summary
-----------------
The endoscopic thyroidectomy approach is gaining popularity in the surgical field. This registry tries to collect the outcomes including quality of life and complication for both endoscopic and conventional thyroidectomy methods.

Official Title
-----------------
Khon Kaen University's Thyroidectomy Registry

Conditions
-----------------
Thyroid Nodule, Thyroid Neoplasms, Thyroid Cancer

Intervention / Treatment
-----------------
* Procedure: Endoscopic approach thyroidectomy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: The patients who underwent thyroidectomy at Khon Kaen University Exclusion Criteria: None
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Endoscopic<br>This group is the patients who underwent endoscopic approaches thyroidectomy. | Procedure: Endoscopic approach thyroidectomy<br>* Thyroid surgery using endoscopy.<br>|
| Conventional<br>This group is the patients who underwent conventional approach thyroidectomy | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from Baseline of QOL Score at 6 months | Validated quality of life score(SF-36) will be measure at baseline and 6 months | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of the symptoms score | The questionnaire for pain, numbness, voice, swallowing and neck movement function will be given and the patient needs to rate from 0 to 10. | At 2, 6, 12, and 24 weeks after surgery | 
| Complication rate | Complications after surgery | At 2, 6, 12, and 24 weeks after surgery | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
endoscopic, thyroidectomy