The Role of Oxytocin in Modulating the Effects of Social Feedback on Achieving Personal Goals

Study Overview
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Brief Summary
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To examine potential differential effects of receiving various social feedback on achieving personal goals,and whether oxytocin would modulate these effects.

Detailed Description
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In the present study, 62 healthy male participants participated in the double-blind, placebo-controlled experiment. Investigators aimed to test the idea that whether oxytocin would modulate subjective responses during receiving various social reward and social punishment about the future outcomes of pursuing personal goals.

Conditions
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Healthy

Intervention / Treatment
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* Drug: oxytocin treatment
* Drug: placebo treatment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy subjects without past or current psychiatric or neurological disorders. Exclusion Criteria: Taking oral contraceptives; No history of head injury and medical or psychiatric illness.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 30 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: oxytocin nasal spray<br>subjects administrating oxytocin were divided into experimental group | Drug: oxytocin treatment<br>* intranasal administration of oxytocin (40 IU)<br>|
| Placebo Comparator: placebo nasal spray<br>subjects administrating placebo were divided into controlled group | Drug: placebo treatment<br>* intranasal administration of placebo (40 IU)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rating of Encouragement after receiving specific social feedback | There're 96 different social feedback totally for four goals which were divided into four runs consisting of 24 different feedback separately for each goal video.Therefore,subjects were instructed to complete the encouragement rating after receiving each specific feedback. To measure the rating,the investigators used the 9-point likert scale in which one refers to the minimum encouragement while nine refers to maximum encouragement. | one hour | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rating of Likeability after receiving specific social feedback | There're 96 social feedback totally for four goals which were divided into four runs consisting of 24 feedback separately for each goal video.Therefore,subjects were instructed to complete the likeability rating after receiving each specific feedback. To measure the rating,the investigators used the 9-point likert scale in which one refers to the minimum likeability while nine refers to maximum likeability. | one hour | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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oxytocin, social reward, social punishment