Clinical and Biological Database in Colon Cancer and Colic Tumors

Study Overview
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Brief Summary
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Developement of a clinical and biological database in colon cancer and colic tumors in order to better understand tumor invasion and metastatic scattering processes. The investigators hope that a better understanding of tumoral invasion process will lead to the discovery of new biomarkers and new drugs.

Detailed Description
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As the second leading cause of cancer-related death in France, colorectal cancer is a major public health problem. Each year, 37 000 cases are newly diagnosed in France and 17 000 patients die of the disease. Colorectal cancer is due to molecular and genetic damages involved in all tumorigenesis steps, transition from healthy tissue to adenoma and finally to invasive carcinoma stage. The investigators hope that a to better understand tumor invasion and metastatic scattering processes will allow therapeutic innovation and the emergence of new biomarkers. However, the study of early tumorigenesis phases as well as advanced stages of the disease is currently limited due to a lack of tissue samples. In this context, the Montpellier Cancer Institute (ICM) decided to initiate a biological collection dedicated to the tissular and blood samples of patients with colorectal cancer.

Official Title
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Prospective, Multicenter, Clinical and Biological Database Set-up in Colon Cancer and Colic Tumors

Conditions
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Cancer Colon

Intervention / Treatment
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* Other: Biological collection


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient undergoing colon cancer surgery (stage I, II, III and IV) Patient operated for liver or lung or peritoneal carcinomatosis metastases originating from colon cancer Patient operated for pre-neoplastic lesion (adenomatous polyp /villous adenoma polyp), Patient with familial polyposis eligible for colectomy Age > 18 years Signed informed consent Exclusion Criteria: Patient not affiliated to Social Protection system Patient unable to understand or comply with study instructions or requirements for psychological, family, social or geographical reasons Patient under guardianship Minor patient

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Biological collection<br>For all the patients include in the study : samples of blood samples collected before or after surgery but also samples in paraffin-embedded tissue sections. In parallel to this biological collection, standardized clinical data will be entered into a database | Other: Biological collection<br>* The biological collection will also include samples of blood samples collected before or after surgery but also samples frozen and/or paraffin-embedded tissue sections.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of clinical risk factors for colorectal cancer |  | Until the study completion : 6 years | 
| Number of biological risk factors for colorectal cancer |  | Until the study completion : 6 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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cancer, colon, tumor, colic