Hospital Management and 1-year Outcome of Patients Aged 70 Years and Older With Severe COVID-19

Study Overview
=================
Brief Summary
-----------------
SARS-COV-2 infection can progress to acute respiratory distress syndrome and require hospitalization in the ICU in 5-20% of affected patients. Age is a major risk factor for developing a severe form and for death. ARDS related to SARS-COV-2 has specific features, including the need for long mechanical ventilation and length of stay and the use of corticosteroid therapy. These specificities are responsible for significant morbidity (neuromyopathy, delirium, post-resuscitation syndrome) and mortality during the first wave (46% at 3 months for the population of patients aged 70 years and over). To investigator's knowledge, no study has evaluated the prognosis in the ICU and the long-term functional outcome of elderly people admitted for a severe or critical form of COVID-19 since the major changes in management (dexamethasone, screening for thrombo-embolic complications, use of high-flow oxygen therapy as first-line treatment...). Investigator therefore propose a 1-year follow-up of a cohort of patients aged 70 and over hospitalised in a conventional service or in intensive care for a severe or critical form of COVID-19. The objectives are to describe the prognosis and functional outcome of hospitalized elderly patients with severe COVID-19.

Official Title
-----------------
Hospital Management and 1-year Outcome of Patients Aged 70 Years and Older With Severe COVID-19

Conditions
-----------------
COVID-19, Elderly Patient

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age ≥ 70 years on admission to hospital diagnosis of SARS-CoV-2 infection defined by a positive RT-PCR test medical or critical care hospitalisation between 1 July 2020 and 31 August 2021 who experienced severe hypoxaemic acute respiratory failure defined as at least 4L/min of oxygen during hospitalisation Exclusion Criteria: Oxygen therapy < 4L/min during hospitalisation Mc Cabe score 3 (chronic disease fatal at 1 year such as stage IV heart failure, ventilated respiratory failure, metastatic cancer, Child C cirrhosis) dementia or cognitive disorders before hospitalisation reported in the medical record patient GIR 1 to 4 before hospitalisation reported in the medical file or deduced from the description of the lifestyle patient with an ADL score < 4 before hospitalisation reported in the medical record or deduced from the description of lifestyle patient living in EHPAD before hospitalisation non-French speaking patient patient under guardianship or curatorship refusal to participate in the study for patients surviving 1 year or refusal by a family member or trusted person

Ages Eligible for Study
-----------------
Minimum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality of patients aged 70 years and over 1 year after diagnosis of SAR-COV2 infection | The mortality was evaluated by the proportion of patients aged 70 years and over who died 1 year after diagnosis of SARS-CoV-2 infection who had severe acute respiratory failure defined by at least 4 L/min of oxygen therapy | 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
COVID-19, ELDERLY PATIENT