The Effect of Ingesting or Rinsing Sucrose and Sucralose on Self-control, Cognitive Performance, and Blood Glucose

Study Overview
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Brief Summary
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The purpose of this study is to examine the effects of ingesting or mouth rinsing a sucrose (carbohydrate) versus a sucralose (carbohydrate-free) drink on self control, cognitive performance, and blood glucose level.

Official Title
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The Effects of Ingesting or Rinsing Sucrose and Sucralose Solutions on Self-control, Cognitive Performance, and Blood Glucose Level

Conditions
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Self-control, Cognitive Performance, Blood Glucose Response

Intervention / Treatment
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* Dietary Supplement: Ingestion of solution
* Dietary Supplement: Rinising of solution


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: BMI 18 - 29 kg/m2 Exclusion Criteria: Dementia Depression Type 2 diabetes Phenylketonuria Intake of medication known to affect glucose metabolism Fasting blood glucose > 7.8 mmol/L

Ages Eligible for Study
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Minimum Age: 50 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Sucrose (50g)<br>A 381g blackcurrant drink (cordial and water) providing 50g of sucrose | Dietary Supplement: Ingestion of solution<br>* Participants will ingest the solution<br>Dietary Supplement: Rinising of solution<br>* Participants rinse the solution in the oral cavity<br>|
| Placebo Comparator: Sucralose (0.92 g sugars)<br>A 381g blackcurrant drink (cordial and water) providing 0.92g of natural sugars | Dietary Supplement: Ingestion of solution<br>* Participants will ingest the solution<br>Dietary Supplement: Rinising of solution<br>* Participants rinse the solution in the oral cavity<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Capillary blood glucose change from baseline following rinsing or ingesting sucrose or sucralose solutions | Change from baseline in capillary blood glucose (assessed by lancet fingerprick and YSI blood glucose analyser) | - 30, -15, - 5, + 5, + 10, + 20, + 30, + 40 minutes relative to rinsing or ingestion of sucrose or sucralose solutions (each separated by 7 days in crossover manner) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Visual verbal learning and memory performance following self-control depletion | Visual verbal learning performance will be assessed by the Visual Verbal Learning Test (Rey, 1964) following a self-control depletion task and ingestion or rinsing of a sucrose or sucralose solution | + 35 minutes post ingestion or rinsing of sucrose or sucralose solutions (each separated by 7 days in crossover manner) | 
| Attention switching performance following self-control depletion | Attention switching performance will be assessed by a switch task (Rogers and Monsell, 1995) following a self-control depletion task and ingestion or rinsing of a sucrose or sucralose solution | + 20 minutes post ingestion or rinsing of sucrose or sucralose solutions (each separated by 7 days in crossover manner) | 
| Continuous blood glucose change from baseline following rinsing or ingesting sucrose or sucralose solutions | A subgroup of 10 participants recruited into the study will be fitted with a continuous glucose monitoring device (CGMS, iPRO) the day preceding each of the test days to measure continuous interstitial blood glucose levels | 24 hours preceding and during ingestion or rinsing of sucrose or sucralose solutions (each separated by 7 days in a crossover manner) |