EVALUATION OF RESPIRATORY MECHANICS AND FUNCTIONALITY IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Study Overview
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Brief Summary
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To associate a lean mass, peripheral muscle strength, kinematic thoracic-abdominal, respiratory metabolic response, mobility and diaphragmatic thickness, verifying its relation with the obstruction level of COPD

Detailed Description
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Individuals with COPD present restriction in their daily lives due to changes and bodily disorders promoted by the disease, such as changes in types of muscle fibers and chronic inflammatory process, causing a low level of physical activity and quality of life, besides being closely Related to the need for hospitalizations and increased mortality. A cross-sectional study with a convenience sample was performed at the Laboratory of Cardiopulmonary Physiotherapy of the Federal University of Pernambuco during the period from December 2016 to February 2018. As measurements of body composition were performed with a bio-balance scale, Evaluation of the peripheral muscle strength will be used the dynamometer, a load cell and electromyography, a kinematic thoracic-abdominal will be measured by optoelectronic plethysmography, a respiratory metabolic response will be verified during the 6-minute walk test using the gas analyzer, and for evaluation of mobility and diaphragmatic thickness are used on ultrasound associated with pneumotachograph.

Official Title
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BODY COMPOSITION, PERIPHERAL MUSCULAR FORCE, KINEMATIC THORACIC-ABDOMINAL, VENTILATORY METABOLIC RESPONSE, DIAPHRAGM MOBILITY AND THICKNESS PREDICTION OF OBSTRUCTION LEVEL OF COPD?

Conditions
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Pulmonary Disease, Chronic Obstructive

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Young adults, adults and elderly subjects Exclusion Criteria: Others respiratory diseases; Heart diseases; Those who are in some previous training program or rehabilitation;

Ages Eligible for Study
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Minimum Age: 21 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group 1<br>COPD mild. The individuals allocated to this group have FEV1 ≥ 80% predicted. | |
| Group 2<br>COPD Moderate. The individuals allocated to this group have 50% ≤ FEV1 < 80% predicted. | |
| Group 3<br>COPD Severe. The individuals allocated to this group have 30% ≤ FEV1 < 50% predicted. | |
| Group 4<br>COPD Very severe. The individuals allocated to this group have FEV1 < 30% predicted. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fat-free mass | Mass of the human body disregarding fat. | Baseline | 
| Quadriceps Force | Quadriceps muscle strength measured during maximum voluntary contraction. | Baseline | 
| Handgrip strength | Maximum voluntary manual holding force. | Baseline | 
| Total chest wall volume | Total volume resulting from the sum of the volume of the pulmonary compartment of the costal, abdominal gradient of the costal and abdominal beds. | Baseline | 
| Oxygen uptake | Consumption of oxygen during an effort. | Baseline | 
| Diaphragm mobility | It is the diaphragmatic movement from the end of the expiration until the end of the inspiration, being able to be realized in tidal volume or starting from the total pulmonary capacity. | Baseline | 
| Diaphragm thickness | Defined as a corpulence of the diaphragm muscle | Baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Body composition, Ultrasound, Chronic Pulmonary Obstructive Disease, Respiratory muscles