Evaluating the Response of the Immune System of People With Long COVID

Study Overview
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Brief Summary
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Many people who have had COVID 19 continue to experience symptoms long after they have recovered from the acute infection. This study will examine the clinical symptoms of people with Long COVID and measure various markers of inflammation in their blood.

Detailed Description
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Patients who attend the Long Covid Recovery Clinic at Huntington Hospital will be offered participation in the study. After giving written informed consent, their medical history along with a description of clinical symptoms given through an extensive questionnaire will be accessed. Venous blood will be collected as a baseline and then at follow up visits (as dictated by changes in clinical symptomatology) for evaluation of corollary immune parameters. Patients will be followed at a minimum of every 2 months for 2 years.

Official Title
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Immune Response to Post Acute Sequelae of SARSCoV2: A Correlation of Clinical Symptoms and Inflammatory Pathways

Conditions
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COVID-19

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Enrolled in Huntington Hospital's Long Covid Recovery Clinic Documented previous infection with SARS-CoV2 Symptoms suggestive of post-acute sequelae of SARS-CoV2 (including but not limited to chronic fatigue, brain fog, muscle and joint pain, cardiac and pulmonary issues, or other factors related to their acute COVID-19 event) Signed Informed Consent Form Exclusion Criteria: No documented positive SARS-CoV2 serologies No post-acute sequelae of SARS-CoV2 symptomatology Incarcerated

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation of symptomatology with inflammatory profiles in patients with Post-Acute Sequelae of SARS-CoV2 (PASC) | Do patient symptoms correlate with abnormalities in inflammatory profiles? | From onset of infection to 24 months | 
| Identification of immunologic and inflammatory features of PASC based on results of immunologic and inflammatory assays | Are there abnormalities in immunologic and inflammatory assays unique to PASC? | From onset of infection to 24 months | 
| Evaluation and delineation of the pathologic pathways and long-term effects of SARS-CoV2 infection | What are the pathological pathways and long-term effects of SARS-CoV2? | From onset of infection to 60 months | 
| Identification of risks factor for PASC | What are the risk factors for PASC? | From onset of infection to 24 months | 
| Identification of potential sites of therapeutic intervention to ameliorate symptomatology of PASC | Are there potential sites of therapeutic intervention to relieve the symptoms of PASC? | From onset of infection to 60 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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post-acute sequelae of SARS-CoV2, post-acute COVID-19 syndrome, long COVID