Effects Of Walnut-Enriched Diet On Blood Lipids And Glucose Profiles In Hyperlipidemic Subjects

Study Overview
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Brief Summary
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Walnuts have been shown to reduce serum lipids in hyperlipidemic individuals with a well-controlled feeding trials. Current study have been determined the effects of daily walnut consumption on serum lipids, fasting glucose and insulin levels in hyperlipidemic individuals.

Detailed Description
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In this, randomized controlled trial, mild to moderate hyperlipidemic subjects were randomly divided into 2 groups as walnut-enriched (n=20) and control (n=17) groups for 6 weeks. All subjects adhered to a medical nutrition therapy as low-fat and low-cholesterol diet. The walnut-enriched group was supplemented with 40 g/day of walnuts added to their diets. In order to follow nutritional status of subjects, they were visited every 15 days (in total 4 times). Anthropometric measurements of the subjects were taken and were monitored at each visit during the study. Blood samples were measured at the beginning and again at the end of the study.

Official Title
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Effects Of Walnut-Enriched Diet On Blood Lipids And Glucose Profiles In Hyperlipidemic Subjects: A Randomized-Controlled Trial: A Randomized-Controlled Trial

Conditions
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Hyperlipidemias

Intervention / Treatment
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* Dietary Supplement: Walnut-enriched Group


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Hyperlipidemic patients who are not using any lipid lowering medications Non-smoker No alcohol consumption Individuals who are having ≤30kg/m2 Individuals who do not have any allergy for nut consumption Female participants who are not pregnant or breastfeeding Individuals should not be in a weight loss programme Having not consumed regular nuts for the last 1 month, Except hypertension, they should not have other chronic diseases (such as diabetes, chronic renal failure) No intense exercise Exclusion Criteria: Failure to meet the criteria for inclusion criteria.

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Control Group<br>In 'Control group' participants had 6 week follow-up without any intervention. | |
| Experimental: Interventional Group<br>In 'Interventional group' participants had 6 week follow-up and during that period of time, they were asked to consume 40g/day walnut. Participants in intervention group was ensured to consume all 40g of walnut every day, during their snack times for 6 weeks. | Dietary Supplement: Walnut-enriched Group<br>* All subjects supplemented with 40 g/day of walnuts for 6 weeks.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Reduction in serum lipids and fasting glucose levels | In both group, participants have decreased serum total cholesterol and LDL-cholesterol.However especially walnut-enrcihed group significantly changed fasting glucose and insulin levels. | Six weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Serum lipids, Hyperlipidemia, Walnut