New Treatment of Alopecia Areata

Study Overview
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Brief Summary
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Abstract: Alopecia areata is believed to be an autoimmune disease resulting from a breach in the immune privilege of the hair follicles causing non scarring hair loss. Methods: our study included 40 patients from may 2019 to july 2022 diagnosed clinically, dermatoscopically and pathologically as alopecia areata Data were enrolled from department of dermatology and venereology, Al-Hussein hospital.

Detailed Description
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For each patient the following will be done : History taking including ( age, sex, disease duration, family history, history of drug intake, smoking and history of any associated disease ). All patients will give a written, informed consent for induction. Basic photographs will be taken to assess site, size (by cm), number, Extent of the patch using D5300 camera with lens (18-55). Patients will be subjected to 3 session of trichloroacetic acid (TCA) 35% one month apart. serial photographs and dermoscopic examination every month will be done and patient will be score. Efficacy will be assessed using prognostic scoring system for density, pigmentation, and texture of growing hair. histopathological examination will be done before the first session and one month after third session.

Official Title
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Efficacy of Trichloroacetic Acid in Patients of Alopecia Areata : Clinico-histopathological Study

Conditions
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Alopecia Areata

Intervention / Treatment
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* Drug: Trichloroacetic acid


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Alopecia areata multilocularis and alopecia totalis. Age from 16-60 years old. Ophiasis pattern alopecia areata. Exclusion Criteria: Age less than 16 and more than 60years old. Alopecia areata of the face. Patient under treatment.

Ages Eligible for Study
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Minimum Age: 16 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: single group<br>Trichloroacetic acid | Drug: Trichloroacetic acid<br>* 5. Patients will be subjected to 3 session of trichloroacetic acid 35% one month apart.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mac Donald Hull and Norris grading system | regrowth of vellus hair, regrowth of sparse pigmented terminal hair, regrowth of terminal hair with patches of alopecia and regrowth of terminal hair on scalp. | 4 weeks after the end of treatment | 
| Scoring of texture of regrown hair | Fine vellus hair, Intermediate hair,Normal coarse hair | after each session and 4 weeks after the end of treatment | 
| Scoring of pigmentation of regrown hair | Partially pigmented, Moderately pigmented, Normally pigmented | after each session and 4 weeks after the end of treatment | 
| Scoring for density of hair regrowth | No hair growth, 1%-25% growth, 26%-50% growth, 51%-75% growth and 76%-100% growth | after each session and 4 weeks after the end of treatment | 
| Scoring of overall response at the end of the study | No response, Minimal response, Moderate response, Good response and Excellent response | after each session and 4 weeks after the end of treatment | 
| histopathological changes | appearance of lymphocytes around hair follicle, appearance of new blood vessels and size of thickness of hair follicles | after each session and 4 weeks after the end of treatment | 
| trichoscopic parameters | determine exclamation mark hairs, black dots, yellow dots and broken hairs | after each session and 4 weeks after the end of treatment | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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alopecia areata AA