Effects on Experimental Dyspnea of High Flow Nasal Cannula

Study Overview
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Brief Summary
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To develop an experimental model of dyspnea by external thoraco-abdominal elastic strapping at rest in order to study the mechanisms involved in the relief of dyspnea by the administration of high flow by nasal cannula (HFNC).

Detailed Description
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This study will measure the effect of HFNC on an experimental model of dyspnea induced by thoraco-abdominal elastic strapping on healthy subjects at rest. The study will also compare the effects on dyspnea of the administration of high flow nasal cannula with and without oxygen added.

Official Title
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Effects on an Experimental Dyspnea by Thoraco-abdominal Elastic Strapping of the High Flow Nasal Cannula

Conditions
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Dyspnea, Healthy Volunteers

Intervention / Treatment
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* Device: Optiflow with an inspired fraction of oxygen of 100%
* Device: Optiflow with an inspired fraction of oxygen of 21%


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy volunteers Exclusion Criteria: chronic pathology active smokers anxiety disorder allergy to latex protected adult woman declared herself pregnant

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Oxygen first<br>Optiflow with an inspired fraction of oxygen of 100% in the first seance Optiflow with an inspired fraction of oxygen of 21 % in the second seance | Device: Optiflow with an inspired fraction of oxygen of 100%<br>* Respiratory gaz heated and humidified system of delivery with a fraction of oxygen inspired of 100%<br>* Other names: High flow nasal cannula with oxygen added;Device: Optiflow with an inspired fraction of oxygen of 21%<br>* Respiratory gaz heated and humidified system of delivery with a fraction of oxygen inspired of 21%<br>* Other names: High flow nasal cannula without oxygen added;|
| Experimental: Air first<br>Optiflow with an inspired fraction of oxygen of 21 % in the first seance Optiflow with an inspired fraction of oxygen of 100 % in the second seance | Device: Optiflow with an inspired fraction of oxygen of 100%<br>* Respiratory gaz heated and humidified system of delivery with a fraction of oxygen inspired of 100%<br>* Other names: High flow nasal cannula with oxygen added;Device: Optiflow with an inspired fraction of oxygen of 21%<br>* Respiratory gaz heated and humidified system of delivery with a fraction of oxygen inspired of 21%<br>* Other names: High flow nasal cannula without oxygen added;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Effects of high flow nasal cannula on strapping induced type of dyspnea | Evaluated by visual annylogic scale | One hour | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Compare the effect of the high flow by nasal cannula with and without oxygen on an experimental dyspnea, evaluated by the differences of changes in the visual analogic scale | Evaluated by visual annylogic scale | One hour | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Dyspnea, High flow nasal cannula