linjc16/ctgov huggingface dataset:
How NAVA Works in Preterm Infants With Irregular Respiratory Efforts

Study Overview
=================
Brief Summary
-----------------
For the infant participating the study, ventilator settings and respiratory variables will be recorded every day and exported to a specific computer using the Servo Record Viewer version 1.0 (Maquet Critical Care AB, Getinge, Gothenburg, Sweden). Collected data gives the value for peak inspiratory pressure (PIP), expiratory tidal volume (Vt), peak Edi, minimum Edi, measured respiratory rate (RR), neural respiratory rate (nRR) and percentage of backup breaths for each minute. All the ventilator data will be inspected and compared with the event logs recorded automatically from the ventilator, which includes all the alarm notification, mode and setting changes, cables connection and disconnection data. Data during disconnection of the Edi cable, malfunction or dislocation of Edi catheter will be excluded from the analysis. The mean values during each day will be computed for each ventilatory variables. If there is a change in the ventilatory setting parameters, we will choose the one which was applied for longer duration in the 24-hour time period. The following clinical characteristics will be collected from medical records: gestational age at birth, birth weight, gender, the time and amount of feeding, medication during the study days, desaturation events, bradycardia events, suction time and methods.

Official Title
-----------------
How NAVA Works in Preterm Infants With Irregular Respiratory Efforts

Conditions
-----------------
Premature Infants, Neurally Adjusted Ventilatory Assist, Ventilator Lung; Newborn, Mechanical Ventilation

Intervention / Treatment
-----------------
* Device: Neurally adjusted ventilatory assist ventilation mode


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: babies who receiving respiratory support with neurally adjusted ventilatory assist babies with informed consents from their parents Exclusion Criteria: babies using anesthetic agents

Ages Eligible for Study
-----------------
Minimum Age: 0 Days
Maximum Age: 36 Weeks

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: Neurally adjusted ventilatory assist ventilation mode|This technique uses the electrical activity of the diaphragm (Edi) to control respiratory support and the NAVA level as an amplification factor that converts the Edi signal into a proportional pressure.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the amount of backup breaths by the ventilator | % time of backup/min according to babies' weight, postmenstrual age and postnatal age | during the respiratory support using NAVA, from day 1 until the end of 36 weeks of postmenstrual age |
Autobiographical Memory

Study Overview
=================
Brief Summary
-----------------
This study aims at the assessment of eye movement during autobiographical retrieval (i.e., retrieval of personal memories) in patients with Alzheimer's Disease.

Detailed Description
-----------------
There is an increased interest in the study of eye movements during the retrieval of autobiographical memories and recent research has demonstrated how retrieval of autobiographical memory can activate eye movement. This research has been however mainly concerned with young adults and, until now, little is known about the relationship between eye movement and autobiographical memory in patients with Alzheimer's Disease. The aim of the current study is therefore to evaluate eye movements during the retrieval of autobiographical memories in patients with Alzheimer's Disease.

Official Title
-----------------
Eye Movement During Autobiographical Memory in Alzheimer's Disease

Conditions
-----------------
Alzheimer's Disease, Autobiographical Memory, Eye Movement, Memory

Intervention / Treatment
-----------------
* Behavioral: Study of eye movements


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria : Diagnosis of Alzheimer's Disease at the mild stage Exclusion Criteria : Neurological/psychiatric disorders (other than Alzheimer's Disease)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 100 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: Study of eye movements|The assessment of eye movement during autobiographical retrieval (i.e., retrieval of personal memories) in patients with Alzheimer's Disease.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of fixations and saccades | Number | Four weeks (from assessment till analysis) | 
| Duration of fixations and saccades | Duration in milliseconds | Four weeks (from assessment till analysis) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pupil size | In millimeter | Four weeks (from assessment till analysis) |
Preoperative Transhepatic Arterial Chemotherapy (TAC) in the Treatment of Liver Metastasis of Resectable Colorectal Cancer

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to investigate whether preoperative TAC is able to improve progression free survival and overall survival in patients receiving liver metastasis resection of colorectal cancer.

Detailed Description
-----------------
We administered TAC(oxaliplatin,FUDR and MMC) 7 days before liver metastasis resection of colorectal cancer. The study endpoints were progression free survival and overall survival as evaluated by intent-to-treat analysis.

Official Title
-----------------
Preoperative Transhepatic Arterial Chemotherapy in the Treatment of Liver Metastasis of Resectable Colorectal Cancer

Conditions
-----------------
Colorectal Cancer

Intervention / Treatment
-----------------
* Drug: tac + folfox4
* Drug: folfox4


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age <= 75 years resectable liver metastasis remnant liver volume >= 70% without other organ metastasis or peritoneum metastasis without contradiction of cardiac and pulmonary diseases Exclusion Criteria: age > 75 years unresectable liver metastasis remnant liver volume < 50% with other organ metastasis or peritoneum metastasis with contradiction of cardiac and pulmonary diseases

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>transhepatic arterial chemotherapy (TAC) were given 7 days before liver metastasis resection. Adjuvant folfox4 chemotherapy was done within 28 days after surgery. | Drug: tac + folfox4<br>* tac: oxaliplatin 100mg + fudr 1g + mmc 10mg 7 days later： operation within 28 days after operation: folfox4<br>|
| Active Comparator: 2<br>Liver metastasis resection was done without TAC. Adjuvant folfox4 chemotherapy was done within 28 days after surgery. | Drug: folfox4<br>* folfox4 will be done within 28 days after liver resection<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| progression free survival |  | 5 years after operation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| overall survival |  | 5 years after operation | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
colorectal cancer, liver metastasis, neoadjuvant chemotherapy
A Double-blind, Group-comparison P-III Study With Zolpidem MR Using Placebo and Nitrazepam in Insomnia Patients

Study Overview
=================
Brief Summary
-----------------
A multicenter, randomized, double-blind, triple-dummy, group-comparison study using placebo and nitrazepam as a comparative drug.

Official Title
-----------------
FK199B (Zolpidem MR Tablet) Phase III Clinical Study -A Double-Blind, Placebo- and Nitrazepam-Controlled, Group-Comparison Study in Patients With Insomnia Associated With Schizophrenia and Manic-Depressive Psychosis

Conditions
-----------------
Sleep Initiation and Maintenance Disorders

Intervention / Treatment
-----------------
* Drug: zolpidem MR
* Drug: nitrazepam
* Drug: placebo


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Nonorganic insomnia associated with schizophrenia and manic-depressive psychosis. Exclusion Criteria: Patients with allergic reactions to zolpidem or nitrazepam; Patients with serious cardiac disorders; serious hepatic impairment; serious renal diseases.

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 64 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br> | Drug: zolpidem MR<br>* oral<br>* Other names: FK199B;|
| Experimental: 2<br> | Drug: zolpidem MR<br>* oral<br>* Other names: FK199B;|
| Active Comparator: 3<br> | Drug: nitrazepam<br>* oral<br>|
| Placebo Comparator: 4<br> | Drug: placebo<br>* oral<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mean wake time after sleep onset during the double-blind period |  | 2 Weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mean total sleep time during the double-blind period |  | 2 Weeks | 
| Mean number of nightly awakenings during the double-blind period |  | 2 Weeks | 
| Mean sleep latency during the double-blind period |  | 2 Weeks | 
| Patient impression during the double-blind period |  | 2 Weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Insomnia, schizophrenia, manic-depressive psychosis, zolpidem
Developing an Imaging-Based Tool to Identify Areas for Prostate Cancer Biopsy

Study Overview
=================
Brief Summary
-----------------
The purpose of the proposed research is to test and validate a Risk Map decision-support system (DSS) for prostate cancer Magnetic Resonance Imaging (MRI) interpretation and identification of clinically significant tumor site(s).

Official Title
-----------------
MRI Derived Quantitative Risk Maps for Prostate Cancer Diagnosis Using Targeted Biopsy

Conditions
-----------------
Prostate Cancer

Intervention / Treatment
-----------------
* Procedure: Diagnostic MRI
* Procedure: Diagnostic Prostate Biopsy
* Device: Risk Map DSS tool


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with known or suspected prostate cancer who have been referred to the Department of Radiology at the University of Chicago Medical Center for a diagnostic MRI exam of the prostate, to be followed by an MRI-guided fusion biopsy of the prostate. Written informed consent. Exclusion Criteria: Patients incapable of giving informed written consent; Patients who cannot adhere to the experimental protocols for any reason, or have an inability to communicate with the researcher; Patients with psychiatric disorders that affect their ability to consent for themselves will be excluded and not the entire population of patients with psychiatric disorders. Prisoners; Minor children (under the age of 18 years old).

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Interventional Arm<br>Participants will undergo diagnostic MRI exam followed by clinical biopsies of suspected prostate cancer tumors. | Procedure: Diagnostic MRI<br>* Participants will be scanned using a standard clinical prostate MRI protocol.<br>Procedure: Diagnostic Prostate Biopsy<br>* Participants will undergo a prostate biopsy as their standard of care treatment. The provider performing biopsy will select areas to be biopsies as part of normal clinical judgment.<br>Device: Risk Map DSS tool<br>* The Risk Map DSS tool will select up to 2 additional areas to be biopsied based on analysis of MRI images. The clinical provider will make final decision on areas to be biopsied.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of biopsy samples positive for prostate cancer versus those that are negative as assessed by receiver operating characteristic curve |  | 12 months | 
| Rate of biopsy samples positive for prostate cancer versus those that are negative as assessed by area under the curve |  | 12 months |
COVID-19 And Lingering Symptoms In Primary Care Patients

Study Overview
=================
Brief Summary
-----------------
The ongoing corona virus disease 2019 (COVID-19) is a viral acute respiratory tract infection caused by server acute respiratory syndrom coronavirus typ 2 (SARS-CoV-2). The signs and symptom of SARS-CoV-2 infection vary and most people with COVID-19 experience illness of mild or moderate severity and recover with symptomatic treatment outside of hospital. Studies have found that some people experience lingering/long-lasting symptoms and only a minority of patients were completely free from COVID-19 related symptoms after two months. About one third still had up to two residual symptoms and 55% had three or more. As far as we know no study on lingering symptoms has been published in patients after a mild or moderate infection managed in primary care settings. The aim of this study is to explore the course of disease over a one year period and describe lingering symptoms and their impact on well-being and daily activities in adult non-hospitalized patients with previous established COVID-19 infection.

Official Title
-----------------
COVID-19 And Lingering Symptoms In Primary Care Patients

Conditions
-----------------
Covid19, Symptoms and Signs

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Confirmed SARS-CoV-2 infection, either by polymeras chain reaction (PCR), or by antigen testing (if authorized/recommended/used by national/local governments) Symptoms consistent with mild to moderate COVID-19 Maximum of 2 weeks since positive SARS-CoV-2 test Aged 18 years and older Patient able and willing to comply with monthly phone calls. Exclusion Criteria: Hospitalisation due to COVID-19

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time to full recovery symptoms | Number of weeks until back to normal | through study completion, a maximum of 1 year |
The Internal Thoracic Artery Skeletonization Study: A Paired, Within-Patient Comparison

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine whether skeletonization of the internal thoracic artery leads to improved flow, increased length, improved sternal perfusion, and decreased pain and dysesthesia in patients undergoing coronary artery bypass surgery

Detailed Description
-----------------
Traditional harvesting of the internal thoracic artery (ITA) for use as a conduit in coronary bypass surgery involves the dissection of a rim of tissue surrounding the artery on either side. Although the benefits of ITA use are well established, there are certain limitations to its routine use. Recent studies, primarily observational, have suggested that skeletonization of the ITA (i.e. harvesting of the ITA alone) may overcome some of these limitations by improving conduit flow, increasing length, and reducing the risk of deep sternal infection in high risk patients. Furthermore, skeletonization of the ITA can potentially preserve intercostal nerves and reduce post-operative pain and dysesthesias associated with ITA harvesting. In order to assess the effects of ITA skeletonization, this is a prospective, randomized, within-patient study design in patients undergoing coronary artery bypass grafting.

Official Title
-----------------
Skeletonized Versus Non-Skeletonized Internal Thoracic Artery Harvest for Coronary Artery Bypass Grafting

Conditions
-----------------
Coronary Artery Disease

Intervention / Treatment
-----------------
* Procedure: Skeletonization of the internal thoracic artery


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients undergoing bilateral internal thoracic artery harvest for coronary artery bypass surgery Exclusion Criteria: Inability to speak English or French Inability to complete follow-up visits

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Skeletonization of the internal thoracic artery|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Intra-operative Internal Thoracic Artery Flow measure prior to coronary anastomoses |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| - Internal Thoracic Artery length |  |  | 
| - Sternal Perfusion (SPECT imaging) |  |  | 
| - Post-operative pain and dysesthesia |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Coronary Artery Bypass, Skeletonization, Internal Thoracic Artery, Flow, Length, Pain
The Effect of a Scratch Off Prompt on Health Engagement

Study Overview
=================
Brief Summary
-----------------
The goal of this project is to determine whether prompting the recipient of a health reminder mailing to scratch off targeted area.

Detailed Description
-----------------
The investigators will randomly assign individuals with different scratch off messages to 3 groups. The investigators are interested in whether the scratch off message will result in an increase in compliance with the recommended health behavior.

Official Title
-----------------
The Effect of a Scratch Off Prompt on Health Engagement

Conditions
-----------------
Blood Pressure Check (Hypertension Screening), Cholesterol Test (Lipid Disorder Screening)

Intervention / Treatment
-----------------
* Behavioral: Scratchoff Prompt: Name of Test
* Behavioral: Scratchoff Prompt: Call to Action
* Behavioral: Control


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Indications according to Spring 2011 CDC criteria for a blood pressure check Indications according to Spring 2011 CDC criteria for a cholesterol test Employee at partner corporation that implemented the study

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Scratch-Off Test Name Condition<br>The name of the test the recipient needs is hidden behind a scratchoff on the reminder | Behavioral: Scratchoff Prompt: Name of Test<br>* A prompt will have the recipient scratch off the message that reveals the name of the test that the recipient needs<br>|
| Experimental: Scratch-Off Call to Action Condition<br>The recipient will be prompted to scratch-off the paper in order to find out how to follow the recommendation that the test be received. | Behavioral: Scratchoff Prompt: Call to Action<br>* A prompt will have the recipient scratch off the message to find out how to follow the recommendation that the test be received.<br>|
| Experimental: Control Condition<br>A control condition with no scratch-off element. | Behavioral: Control<br>* No scratch-off element<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of Participants that schedule an appointment for receipt of the relevant test |  | up to 52 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
behavioral economics, nudge, scratch off, blood pressure check, cholesterol test