Prevalence of Acromegaly in a Diagnostic Consultation for Sleep Apnea Syndrome

Study Overview
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Brief Summary
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Prevalence of sleep apnea syndrome in patients with acromegaly is about 70%. It seems that comorbidities of arterial hypertension or type 2 diabetes are more severe in patients with acromegaly and sleep apnea syndrome. Besides sleep apnea syndrome associated to acromegaly gives rise to few symptoms, that explains it is under diagnosed. The mechanisms of the association are based on maxillofacial modifications linked to acromegaly, a thickening of soft tissues with deposits of glyco-aminoglycanes but probably also because of the associated obesity, of the potential existence of a goiter and a muscular dystrophy of the dilatative muscles of the pharynx. At present, no study clearly documented prevalence of acromegaly in a diagnostic consultation for sleep apnea syndrome.

Detailed Description
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60 investigators will participate to this study. They will be chosen among those participating to the sleep observatory of the federation of pneumology (www.osfp.fr). All participating pneumologists would have to fill in the questionnaire (co-morbidities, concomitant treatments, biological analysis) directly online and also clinical signs and symptoms of acromegaly. A blood test for the insulin-like growth factor (IGF-1) dosage will be systematically prescribed to the patient. Pneumologists will have to include all consecutive patients presenting with sleep apnea syndrome suspicion. According to first IGF-1 results, patients may have to do a second blood test in a referenced laboratory to confirm the dosage.

Official Title
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Prevalence of Acromegaly in a Diagnostic Consultation for Sleep Apnea Syndrome: A Prospective, National and Multicentric Study

Conditions
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Sleep Apnea Syndrome

Intervention / Treatment
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* Other: Diagnosis of acromegaly


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Body mass index < 40 kg/m2 Patient consulting for sleep breathing disorder Informed consent signed patient covered by french health insurance Exclusion Criteria: Other sleep disorder already diagnosed Pregnant women Patients participating in an other study

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Acromegaly<br>Diagnosis of acromegaly | Other: Diagnosis of acromegaly<br>* Biological analysis of IGF-1<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| determination of acromegaly prevalence | IGF-1 (insulin-like growth factor-1) quantification in blood punction | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| description of clinical signs of acromegaly associated to sleep apnea syndrome (Epworth scale) | Score to Epworth scale will be compared between patients with sleep apnea syndrome with acromegaly and patients with sleep apnea syndrome only. | 1 year |