Association of Long-term Conditions With Survival Following Heart Attack in England and Wales

Study Overview
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Brief Summary
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This study aims to determine the extent to which pre-existing long-term conditions are associated with survival following a heart attack (acute myocardial infarction) using observational data from the UK's national heart attack register.

Detailed Description
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Using observational data from the Myocardial Ischaemia National Audit Project (MINAP) of all hospitalisations for acute myocardial infarction in all acute hospitals in England and Wales, this study aims to determine the extent to which pre-existing long-term conditions are associated with survival following acute myocardial infarction. The study will include an investigation of individual long term conditions for patients with acute myocardial infarction, including chronic heart failure, cerebrovascular disease, diabetes mellitus, chronic obstructive pulmonary disease, chronic renal failure or peripheral vascular disease as well as the combination of such conditions and their resulting impact on long term all-cause mortality (up to 8.4 years). In addition, an investigation of the association of receipt of guideline recommended care for acute myocardial infarction patients with pre-existing long term conditions will be made.

Official Title
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Association of Long-term Conditions With Survival Following Acute Myocardial Infarction in England and Wales

Conditions
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Chronic Renal Failure, Acute Myocardial Infarction, Diabetes Mellitus, Peripheral Vascular Disease, Chronic Heart Failure, Cerebrovascular Disease, Chronic Obstructive Pulmonary Disease

Intervention / Treatment
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* Other: long term conditions


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients must be 18 years or older Exclusion Criteria: Patients for which mortality data are missing

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: long term conditions|Long term conditions including diabetes mellitus, chronic obstructive pulmonary disease or asthma, chronic heart failure, chronic renal failure, cerebrovascular disease or peripheral vascular disease.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patients who died from any cause by the end of the study censoring period | Death data was obtained from national death records from the Office for National Statistics | 8.4 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patients who received guideline recommended therapy during the study period | All guideline recommended therapies for acute myocardial infarction relevant to the duration of the study period (2003 to 2013) will be assessed. | Any guideline therapy administered during the patients hospital admission for acute myocardial infarction, an average of 4 days |