Seoul National University Pituitary Disease Cohort Study

Study Overview
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Brief Summary
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The purpose of this study is to investigate the treatment and natural history of pituitary disease. We have a longstanding interest in pituitary disease including acromegaly, central diabetes insipidus, and nonfunctioning pituitary adenoma. We will continue to follow patients and recruit new patients for treatment and follow-up. Blood and pituitary tumor tissue (when available through clinical care) will be saved for future analyses related to pituitary disease.

Detailed Description
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Subjects for this study will be recruited if they are: Adults, male or female aged 18 years or older Have been diagnosed with pituitary diseases

Official Title
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Seoul National University Pituitary Disease Cohort Study

Conditions
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Pituitary Incidentaloma, Acromegaly, Central Diabetes Insipidus, Pituitary Stalk Compression Hyperprolactinaemia, Cushing's Disease, Pituitary Disease, Pituitary Tumor, Prolactinoma

Intervention / Treatment
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* Other: Dynamic hormone study and Magnetic resonance imaging


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Subjects for this study will be recruited if they are: Adults, male or female aged 18 years or older diagnosed with pituitary diseases such as acromegaly, Cushing's disease, hyperprolactinemia, nonfunctioning pituitary adenoma, pituitary stalk lesions, central diabetes insipidus, and craniopharyngiomas Exclusion Criteria: Patients who do not agree with the study

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Acromegaly<br>Patients diagnosed with acromegaly | Other: Dynamic hormone study and Magnetic resonance imaging<br>* Medical history Imaging examination including brain magnetic resonance imaging Blood (Basal hormone study and follow-up study) and pituitary tumor tissue<br>|
| Cushing's disease<br>Patients diagnosed with Cushing's disease | Other: Dynamic hormone study and Magnetic resonance imaging<br>* Medical history Imaging examination including brain magnetic resonance imaging Blood (Basal hormone study and follow-up study) and pituitary tumor tissue<br>|
| Hyperprolactinemia/prolactinomas<br>Patients diagnosed with hyperprolactinemia/prolactinoma | Other: Dynamic hormone study and Magnetic resonance imaging<br>* Medical history Imaging examination including brain magnetic resonance imaging Blood (Basal hormone study and follow-up study) and pituitary tumor tissue<br>|
| Pituitary stalk lesions<br>Patients diagnosed with pituitary stalk lesions | Other: Dynamic hormone study and Magnetic resonance imaging<br>* Medical history Imaging examination including brain magnetic resonance imaging Blood (Basal hormone study and follow-up study) and pituitary tumor tissue<br>|
| Nonfunctioning pituitary adenomas<br>Patients diagnosed with nonfunctioning pituitary adenomas | Other: Dynamic hormone study and Magnetic resonance imaging<br>* Medical history Imaging examination including brain magnetic resonance imaging Blood (Basal hormone study and follow-up study) and pituitary tumor tissue<br>|
| Central diabetes insipidus<br>Patients diagnosed with central diabetes insipidus | Other: Dynamic hormone study and Magnetic resonance imaging<br>* Medical history Imaging examination including brain magnetic resonance imaging Blood (Basal hormone study and follow-up study) and pituitary tumor tissue<br>|
| Craniopharyngioma<br>Patients diagnosed with craniopharyngiomas | Other: Dynamic hormone study and Magnetic resonance imaging<br>* Medical history Imaging examination including brain magnetic resonance imaging Blood (Basal hormone study and follow-up study) and pituitary tumor tissue<br>|
| Others<br>Patients diagnosed with other suprasellar/parasellar lesions | Other: Dynamic hormone study and Magnetic resonance imaging<br>* Medical history Imaging examination including brain magnetic resonance imaging Blood (Basal hormone study and follow-up study) and pituitary tumor tissue<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Treatment outcome of pituitary diseases | Remission rate | Up to 10 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Complications of pituitary disease | Visual field defect or hypopituitarism, hormone hyperfunction-related complications | Up to 10 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Pituitary Diseases, Pituitary incidentaloma, Central Diabetes Insipidus, Pituitary Neoplasms