Changes in Muscle Morphology Resulting From Anterior Cruciate Ligament Reconstruction

Study Overview
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Brief Summary
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The aim of this study is to gain new knowledge on the impact of hamstring tendon harvest and apply that knowledge to the treatment and management of patients who undergo anterior cruciate ligament (ACL) reconstruction. There are three main components of this study: How do muscle shape, size, strength, and ability to function change following hamstring grafting for ACL reconstruction; How does physical activity change following ACL reconstruction; Is there a difference in outcome if graft harvest is done from the injured versus uninjured limbs

Official Title
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Changes in Muscle Morphology Resulting From ACL Reconstruction: Impact on Strength and Function

Conditions
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Isolated Anterior Cruciate Ligament Rupture

Intervention / Treatment
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* Other: Autograft STG harvest from ACL-deficient leg
* Other: Autograft harvest contralateral to ACL-deficient leg


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: between 18 and 50 years old; isolated ACL rupture confirmed on MRI Exclusion Criteria: other physical or mental health issues that affect ability to complete rehabilitation and/or study follow-ups

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Standard<br>ACL reconstruction with autograft harvest of STG from ACL-deficient leg | Other: Autograft STG harvest from ACL-deficient leg<br>* Semitendinosus-gracilis graft harvest is undertaken on same limb that is undergoing ACL reconstruction<br>|
| Experimental: Autograft harvest of STG from ACL-deficient leg<br>Autograft harvest of STG from leg contralateral to ACL-deficient leg | Other: Autograft harvest contralateral to ACL-deficient leg<br>* Semitendinosus-gracilis graft harvest is undertaken on limb contralateral to that undergoing ACL reconstruction<br>|
| No Intervention: Normal matched<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Muscle cross sectional area | Measured on bilateral MRI taken from ischial tuberosity to 10 cm below knee joint line | 12 months post-surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Knee flexion and extension isokinetic strength | Eccentric anc concentric strength measured at 60, 150, and 270 degrees/second on dynamometer in sitting and in 5 degrees hip flexion | 12-months post-surgery | 
| Physical activity | 7-day record of activity using accelerometer. | 12 months post-surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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anterior cruciate ligament, hamstring, semitendinosus, gracilis, graft