Effect of 3 Years of Exercise in Patients With Atrial Fibrillation

Study Overview
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Brief Summary
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This is a substudy of Generation 100. The investigators will follow the persons with atrial fibrillation to see if 3 years of interval or moderate exercise affects the burden of atrial fibrillation, symptoms, use of health services or echocardiographic findings.

Official Title
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Effect of 3 Years of Exercise in Patients With Atrial Fibrillation - A Generation 100 Substudy

Conditions
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Atrial Fibrillation

Intervention / Treatment
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* Behavioral: Interval exercise
* Behavioral: Moderate exercise
* Behavioral: Control


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Included in the Generation 100 study Atrial fibrillation diagnosis verified by ECG Exclusion Criteria: -

Ages Eligible for Study
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Minimum Age: 70 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Moderate exercise<br>Moderate exercise | Behavioral: Moderate exercise<br>* Moderate exercise with pulse about 70% of max pulse; 3 times a week for 3 years.<br>|
| Experimental: Control<br>Control group | Behavioral: Control<br>* Given information on recommendations for physical activity.<br>|
| Experimental: Interval exercise<br>interval exercise | Behavioral: Interval exercise<br>* 4 times of 4 minutes intervals at an intensity of 90-95% of maximum heart rate and active pauses of 3 minutes between intervals. 3 times a week for 3 years.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in burden of atrial fibrillation | Burden of atrial fibrillation; measured by Holter monitor and the patient. | At baseline and 3 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Size of left ventricle | Echocardiographic measures | At baseline and 3 years | 
| Quality of life | Measured with SF-36 | At baseline and 3 years | 
| Endothelial function | Diameter of brachial artery measured by ultrasound. | At baseline and 3 years | 
| Maximal oxygen uptake |  | At baseline and 3 years | 
| Atrial extrasystoles | Measured with Holter monitor | At baseline and 3 years | 
| Number of hospitalisations with atrial fibrillation as main diagnosis |  | Total number during the 3 year intervention period | 
| Total number of electrical cardioversions | Number of electrical cardioversions because og atrial fibrillation | During the 3 years of intervention | 
| Change in burden of atrial fibrillation | Measured by Holter and the patient. | Baseline and 1 year | 
| Size of left atrium | Echocardiography | Baseline and 1 year | 
| Function of left atrium | Echocardiographic measures | At baseline and 3 years | 
| Function of left ventricle | Echocardiographic measures | At baseline and 3 years | 
| Size of left atrium | Echocardiographic measures | At baseline and 3 years | 
| Symptom burden | Measured with Symptom and Severity Checklist. | At baseline and 3 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Atrial fibrillation, Exercise