Effects of Different Deflation Methods on Coughing Response and Hemodynamics During Extubation

Study Overview
=================
Brief Summary
-----------------
Patients with endotracheal intubation and general anesthesia often have severe choking and hemodynamic fluctuations during the extubation period, which increases the risk of cerebrovascular accident, arrhythmia, incision bleeding and so on . This study aimed to observe the effects of different methods of deflating of endotracheal tube cuffs on cough response and hemodynamics during periextubation in patients undergoing general anesthesia surgery.

Official Title
-----------------
Effects of Different Deflation Methods on Coughing Response and Hemodynamics During Extubation

Conditions
-----------------
Deflating Method

Intervention / Treatment
-----------------
* Behavioral: Tracheal tube cuffs differ in deflation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Elective endotracheal intubation under general anesthesia. Operation time < 3 h. ASA grade I or II. Age 18 65 years old. Exclusion Criteria: Throat and neck surgery. Those assessed to have a high risk of reflux aspiration. Difficulty intubation. History of snoring before surgery. Recent respiratory illness such as chronic cough. Previous airway hyperresponsiveness, such as asthma. recent use of cough suppressants. Patients with severe heart, liver and kidney diseases.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Slowly and evenly draw the gas in the cuff<br> | Behavioral: Tracheal tube cuffs differ in deflation<br>* When removing the endotracheal tube, the gas in the cuff is drawn at a uniform and slow pace<br>|
| No Intervention: One-time aspiration of tracheal catheter cuff gas<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Grading of cough reaction | Grading of cough reactions | During extubation procedure | 
| Change in Blood pressure | Hemodynamics | Preoperatively, immediately before extubation, immediately after extubation, 1 minute after extubation, 3 minutes after extubation, 10 minutes after extubation | 
| Change in Heart rate | Hemodynamics | Preoperatively, immediately before extubation, immediately after extubation, 1 minute after extubation, 3 minutes after extubation, 10 minutes after extubation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Adverse reactions | Hypoventilation, pharyngeal discomfort, hoarseness | Within 24 hours after removal of the endotracheal tube | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Deflating method, Extubation phase, Coughing reaction