Multicentre Registry of Patients With Spontaneous Acute Intracerebral Hemorrhage in Catalonia (HIC-CAT).

Study Overview
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Brief Summary
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A population-based registry in Catalonia of patients with acute spontaneous Intracerebral Hemorrhage, to investigate whether type of center and time from onset to admission is associated with functional outcome and mortality.

Detailed Description
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Introduction. Recent studies show that there are potentially beneficial therapeutic measures for the patient with acute intracerebral hemorrhage (ICH), which should be applied urgently and that some would only be available in tertiary stroke centers (TSC). However, the transportation criteria for ICH patients are not well defined. Objectives: Design and implementation of a registry (HIC-CAT) of patients with HIC in the healthcare network of public hospitals in Catalonia, which does not modify the current logistics but collects data related to patients and TSC, interhospital transfers and non-TSC centers. The registry will allow us to evaluate the hypothesis that: 1) Patient care in TSC decreases the probability of death or dependence in patients with spontaneous ICH compared to non-TSC; and 2) The shorter the time until admission to a TSC, the better the survival and functional outcome. This will be due to the application of diagnostic, therapeutic and structural measures at the TSC. In addition, organ donation will be more frequent in a TSC. Methods: Observational, prospective, multicentre, population study of 2500 consecutive patients with spontaneous ICH of less than 24 hours from the onset of symptoms and Rankin scale score 0-3. We will collect times, clinical and radiological variables, vital and functional outcome at 3 months follow-up. Number of organ donations. Primary variable: Functional outcome at 3 months (Rankin 0-3). Statistics: Multivariate analysis with logistic regression, propensity matching scores.

Official Title
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Multicentre Registry of Patients With Spontaneous Acute Intracerebral Hemorrhage in Catalonia

Conditions
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Intracerebral Hemorrhage

Intervention / Treatment
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* Other: Type of center


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient with a diagnosis of spontaneous intracerebral hemorrhage who is diagnosed in any of the participant hospitals Exclusion Criteria: Traumatic intracerebral hemorrhage >24 hours from onset to admission Prior Rankin scale score >3

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Type of center|Tertiary versus non-tertiary|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Functional outcome | Rankin scale score, favourable if 0,1, 2 or 3 | 3 months after onset | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality | mortality within the first 3 months after onset | 3 months | 
| Hematoma expansion | increase in hematoma volume (>33% and/or 6 ml) from baseline CT to follow-up CT | 72 hours | 
| Stroke Unit admission | Percentage of patients admitted to a stroke unit | 3 months | 
| Neurological worsening | increase in 4 or more points in the NIHSS score and/or decrease >1 point in the Glasgow coma scale score | During admission | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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intracerebral hemorrhage, outcome, transportation, transfer, prognosis