To Explore the Related Factors of Cough After Thoracoscopic Pneumonectomy

Study Overview
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Brief Summary
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To explore the related factors of cough after Uniport video-assisted thoracoscopic surgery pneumonectomy, and to provide theoretical basis and social accumulation of new knowledge for the diagnosis and treatment of cough after pneumonectomy in the future.

Detailed Description
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Intractable cough after thoracoscopic pneumonectomy is one of the common complications after pneumonectomy. The incidence of cough can reach 25% ≤ 50%. Cough after operation can aggravate the pain of incision, prolong the hospitalization time, increase the cost of hospitalization, affect the conversation and even sleep of the patients, increase the psychological burden of the patients, and reduce the quality of life of the patients accordingly. Therefore, through this study, the investigators hope to understand the related factors of cough after thoracoscopic pneumonectomy and whether there are predictable risk factors, so as to provide theoretical basis for reducing the occurrence of cough after pneumonectomy.

Official Title
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Multivariate Analysis of Cough After Uniport Video-assisted Thoracoscopic Surgery Pneumonectomy

Conditions
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Cough

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age ≥ 18 years old, male and female Uniport video-assisted thoracoscopic surgery No cough symptoms within two weeks before operation Informed consent form was signed before operation Exclusion Criteria: Diabetes , heart, brain, liver and kidney diseases Chest radiographs / CT in recent months indicate pneumonia Pulmonary function cannot tolerate lobectomy / segmental / cuneiform resection Distant metastasis patients Before operation, there were internal causes of cough (including respiratory tract infectious diseases, pharyngitis, allergic rhinitis, posterior nasal drip syndrome, etc.)

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Clinical characteristics of the patients<br>including sex,age,smoking history,tumor location and tumor diameter | |
| Logistic regression analysis of influencing factors of c<br>The Leicester Cough Questionnaire in Mandarin Chinese (LCQ-MC) was used to evaluate the degree of cough in patients. The LCQ-MC is divided into three dimensions: physical, psychological and social. There are a total of 19 questions, and each question has seven options (positive scoring, grades 1-7; the higher the score is, the lighter the cough). | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The mean Leicester Cough Questionnaire in Mandarin Chinese (LCQ-MC) score before and after surgery | The Leicester Cough Questionnaire in Mandarin Chinese (LCQ-MC), which assesses the cough-related quality of life, consists of 19 items divided into three domains: the physical (8 items), psychological (7 items) and social (4 items) domains. A 7-point Likert scale was used to score individual domains. The total scores ranged from 3 to 21, with a higher score indicative of a better health status | The day before surgery,two weeks after surgery,one month after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hospitalization days | The numbers of days of patients stay in the hospital after surgery | From the first days after surgery to discharge,up to 4 weeks | 
| Drainage | The total volume of fluid | Measure the volume every 24 hours,up to 4 weeks | 
| Anesthesia time | Time from patient anesthesia to extubation | Record total anesthesia during surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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postoperative cough, Multivariate analysis, non-small cell lung cancer (NSCLC), Uniport Video-assisted Thoracoscopic Surgery