Corneal Biomechanics During Pregnancy

Study Overview
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Brief Summary
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It is known that intraocular pressure changes during pregnancy. Collagen structure changes during pregnancy to enable softening of the symphysis, whitening of the birth chanel, and, thus, ultimately to enable delivery of a child. The cornea consists of highly structured collagen fibers. Hence, it seams logically that corneal biomechanics also change during pregnancy.

Detailed Description
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It is known that intraocular pressure changes during pregnancy. Collagen structure changes during pregnancy to enable softening of the symphysis, whitening of the birth chanel, and, thus, ultimately to enable delivery of a child. The cornea consists of highly structured collagen fibers. Hence, it seams logically that corneal biomechanics also change during pregnancy. Measurement of intraocular pressure is highly dependant on corneal properties. With the Corvis ST device by Ocular Inc. it is possible to measure intraocular pressure and investigated corneal biomechanics. The aim of this study is therefore to compare corneal biomechanical properties during the third trimester with corneal biomechanical properties at 3 months after delivery.

Official Title
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Change in Corneal Biomechanics During Pregnancy

Conditions
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Pregnancy

Intervention / Treatment
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* Device: Non-Contact measurement of corneal properties


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: females pregnant age 18 to 38 yo uncomplicated singleton pregnancy Exclusion Criteria: any history of ocular disease or surgery other than conjunctivitis, especially no history of glaucoma or corneal disease systemic diseases, i.e. diabetes, hypertension, collagenase current contact lens wear before pregnancy taking any systemic or ocular medications

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 38 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Pregnant women<br>Pregnant woman, age 18 to 38 yo, with uncomplicated singleton pregnancy and no ocular diseases. | Device: Non-Contact measurement of corneal properties<br>* Corneal Properties will be measurement with the non-contact Corvis ST Air-Puff Tonometer by Oculus Inc.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Deformation Amplitude | Change in Deformation Amplitude (in millimeters) at 3 month post delivery compared to during third trimester will be assessed. | at 3 month post delivery compared to during third trimester | 
| Change in Applanation Length | Change in Applanation Length (in millimeters) at 3 month post delivery compared to during third trimester of the pregnancy will be assessed. | at 3 month post delivery compared to during third trimester of the pregnancy | 
| Change in Corneal Velocity | Change in Corneal Velocity (in meters/second) at 3 month post delivery compared to during third trimester of the pregnancy will be assessed. | at 3 month post delivery compared to during third trimester of the pregnancy | 
| Change in corneal thickness | Change in corneal thickness (in millimeters) at 3 month post delivery compared to during third trimester of the pregnancy will be assessed. | at 3 month post delivery compared to during third trimester of the pregnancy | 
| Change in Intraocular pressure | Change in intraocular pressure (in millimeters of mercury, mmHg) at 3 month post delivery compared to during third trimester of the pregnancy will be assessed. | at 3 month post delivery compared to during third trimester of the pregnancy | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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pregnancy, corneal biomechanical properties, intraocular pressure