tDCS Response Prediction Using EEG in Stroke

Study Overview
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Brief Summary
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Patients with chronic stroke (>6 months after stroke) having unilateral upper limb hemiparesis will be recruited. Patients will maintain their usual inpatient rehabilitation including occupational therapy. At baseline (T0) and after 2weeks of enrollment (T1), Fugl-Meyer assessment (FMA) will be assessed at each time. And patients with the changes of FMA between T0 and T1 less than 3 points will be finally recruited. The enrolled patients will receive additional 30-min cathodal transcranial direct current stimulation (tDCS) over the contralesional motor cortex for 10 consecutive weekdays, with maintaining their usual conventional rehabilitation. At T1 and immediately after 10-seessions of tDCS (T2) and 1 month after completing 10-tDCS session (T3), FMA, Actional Research Arm Test (ARAT), Box and Block Test (BBT) and electroencephalography (EEG) were measured.

Official Title
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Prediction of Transcranial Direct Current Stimulation (tDCS) Responses Using Electroencephalography (EEG )in Patients With Chronic Stroke

Conditions
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Stroke, Rehabilitation, Transcranial Direct Current Stimulation, Motor Recovery

Intervention / Treatment
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* Device: Cathodal transcranial direct current stimulation (tDCS) over the contralesional motor cortex


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age ranges from 19 to 85 yrs old stroke patients with unilateral hemiparesis 1st ever stroke chronic stroke (>6 months after stroke) Exclusion Criteria: recurrent stroke history of traumatic brain injury Minimental state examination score is 15 or less. Unstable medical conditions Severe delirium, disorders of consciousness pregnancy can not attach tDCS electrode on the scalp due to skin conditions can not maintain the sitting position intracranial metals

Ages Eligible for Study
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Minimum Age: 19 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: Cathodal transcranial direct current stimulation (tDCS) over the contralesional motor cortex|Cathodal tDCS will be applied to the contralesional motor cortex with 2mA intesntisy for 30 mins/day. Total 10 sessions will be applied.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in Fugl-Meyer Assesment Score 1 |  | Between T1 (before tDCS) and T2 (immediately after completing 10 sessions of tDCS) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in Fugl-Meyer Assesment Score 2 |  | Between T2 (immediately after completing 10 sessions of tDCS) and T3 (1 month after completing 10 sessions of tDCS) | 
| Changes in Action Research Arm Test Score 1 |  | Between T1 (before tDCS) and T2 (immediately after completing 10 sessions of tDCS) | 
| Changes in Action Research Arm Test Score 2 |  | Between T2 (immediately after completing 10 sessions of tDCS) and T3 (1 month after completing 10 sessions of tDCS) | 
| Changes in Box and Block Test Score 1 |  | Between T1 (before tDCS) and T2 (immediately after completing 10 sessions of tDCS) | 
| Changes in Box and Block Test Score 2 |  | Between T2 (immediately after completing 10 sessions of tDCS) and T3 (1 month after completing 10 sessions of tDCS) | 
| Changes in EEG index1 | Various kinds of EEG indexe.g., network indexes, event-related dysynchronization, mu suppression) will be surveyed. | Between T1 (before tDCS) and T2 (immediately after completing 10 sessions of tDCS) | 
| Changes in EEG index 2 | Various kinds of EEG indexe.g., network indexes, event-related dysynchronization, mu suppression) will be surveyed. | Between T2 (immediately after completing 10 sessions of tDCS) and T3 (1 month after completing 10 sessions of tDCS) |