linjc16/ctgov huggingface dataset:
Evaluation of TAR Technique in the Treatment of Huge Abdominal Wall Hernia and Large Abdominal Wall Defect With or Without Botox Injection .

Study Overview
=================
Brief Summary
-----------------
Aim of the work In this study, we will evaluate posterior component separation (TAR) technique with or without Botox injection for open huge ventral hernia and large abdominal wall defect repair. The primary outcome will be recurrence while the secondary outcome will be infection, postoperative complications (bleeding and dehiscence), pain score, operative time, hospitalization, need for drain, time for drain removal and pulmonary function test before and after surgery. This prospective clinical study will be performed on 40 eligible patients admitted to general surgery department at Mansoura University Hospi

Official Title
-----------------
Evaluation of TAR Technique in the Treatment of Huge Abdominal Wall Hernia and Large Abdominal Wall Defect With or Without Botox Injection .

Conditions
-----------------
TAR Technique

Intervention / Treatment
-----------------
* Procedure: Tar with Botox


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adult patient fit for general anesthesia with huge ventral hernia (primary, incisional or recurrent).Any patient with large abdominal wall defect secondary to abdominal wall tumor excision or burst after surgery Exclusion Criteria: Patients who are unfit for general anaesthesia. Poor pulmonary function tests. Pregnant females. Patient younger than 18 years. Immunodeficiency. Patient with psychiatric disease disabling surgical intervention. Patients who refuse to participate in our study.

Ages Eligible for Study
-----------------
Minimum Age: 12 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: TAR with Botox<br>Evaluation of TAR technique in the treatment of huge abdominal wall hernia and large abdominal wall defect Botox injection . | Procedure: Tar with Botox<br>* Evaluation of TAR technique in the treatment of huge abdominal wall hernia and large abdominal wall defect with Botox injection .<br>|
| Active Comparator: TAR without Botox<br>Evaluation of TAR technique in the treatment of huge abdominal wall hernia and large abdominal wall defect without Botox injection . | Procedure: Tar with Botox<br>* Evaluation of TAR technique in the treatment of huge abdominal wall hernia and large abdominal wall defect with Botox injection .<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Recurrence | Recurrence of the ventral hernia | one year |
Effect of Some Drugs on Liver Fibrosis

Study Overview
=================
Brief Summary
-----------------
Effect of Some Drugs on Liver Fibrosis

Detailed Description
-----------------
The study aimed at evaluating the effect of Some Drugs on Liver Fibrosis

Official Title
-----------------
Clinical Study Evaluating the Efficacy of Renin Angiotensin System Inhibitors on the Extent of Liver Fibrosis in Patients With Chronic Hepatitis C

Conditions
-----------------
Liver Fibroses

Intervention / Treatment
-----------------
* Drug: Candesartan
* Drug: Ramipril


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: chronic hepatitis C Exclusion Criteria: Acute hepatitis Thalassemia

Ages Eligible for Study
-----------------
Minimum Age: 20 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Control group<br>No intervention | |
| Active Comparator: Candesartan<br>Candesartan 8 mg/day | Drug: Candesartan<br>* Candesartan 8 mg/day<br>* Other names: Cansartan;|
| Active Comparator: Ramipril<br>Ramipril 1.25 mg/day | Drug: Ramipril<br>* ramipril 1.25 mg/day<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Fibroscan or APRI score | Change in Fibroscan or APRI score | 6 months |
Evaluation of the Safety of Lubiprostone in Pediatric Participants Aged ≥ 6 Years to < 18 Years With Functional Constipation

Study Overview
=================
Brief Summary
-----------------
A study of the safety of lubiprostone in pediatric participants aged ≥ 6 Years to < 18 years diagnosed with functional constipation.

Detailed Description
-----------------
To assess the long-term safety and tolerability of oral lubiprostone 12 or 24mcg capsules dosed twice daily (BID) when administered orally for 24 weeks in pediatric participants with functional constipation. Evaluation of lubiprostone safety and tolerability is the primary objective in this study.

Official Title
-----------------
A Multicenter, 6-month, Open-label Safety Study of Lubiprostone in Pediatric Subjects Aged ≥ 6 Years to < 18 Years With Functional Constipation

Conditions
-----------------
Constipation - Functional

Intervention / Treatment
-----------------
* Drug: Lubiprostone


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Medically-confirmed diagnosis of Functional Constipation per Rome III Diagnostic Criteria for Childhood Functional Constipation At least 6 years of age but less than 18 years of age at the time of randomisation Only stable dose of selective serotonin re-uptake inhibitors (SSRIs), serotonin-specific reuptake inhibitor (SNRIs), or monoamine oxidase inhibitors (MAO) inhibitors are allowed if participant is taking antidepressants Exclusion Criteria: Any gastrointestinal (GI) condition, other than constipation, affecting GI motility or defecation Untreated faecal impaction at the time of screening Medical/surgical condition that might interfere with the absorption, distribution, metabolism, or excretion of the study medication

Ages Eligible for Study
-----------------
Minimum Age: 6 Years
Maximum Age: 17 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Lubiprostone<br>Participants received lubiprostone twice daily (BID). Participants received either lubiprostone 12 mcg BID, lubiprostone 24 mcg BID (dose based on participant's weight) up to 24 weeks. | Drug: Lubiprostone<br>* 12 or 24 mcg soft capsules for oral administration.<br>* Other names: Amitiza;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of Participants With at Least One Treatment-emergent Adverse Event (TEAE) | Adverse events with onset dates after the administration of the first dose of study medication or prior to the last day of treatment plus 7 days are considered treatment-emergent. | within 25 weeks |
Gum Chewing and Postoperative Intestinal Function After Gynecolgic Operations

Study Overview
=================
Brief Summary
-----------------
The investigators aimed to assess whether postoperative gum chewing improve intestinal functions.

Detailed Description
-----------------
We will randomize patients into two groups after gynecologic operations. One group will chew gum, the other group not and we will assess the gastrointestinal function functions.

Official Title
-----------------
Effect of Gum Chewing on Intestinal Functions After Gynecologic Operations

Conditions
-----------------
Gastrointestinal Disorder Postoperative

Intervention / Treatment
-----------------
* Other: chewing gum


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Women underwent gynecologic operation Women who are eligible for gum chewing Exclusion Criteria: Women with previous gastrointestinal intervantion Women with previous abdominal surgery

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: chewing gum positive<br>chewing gum group will chew gum | Other: chewing gum<br>* postoperative gum chewing to improve gastrointestinal function<br>|
| No Intervention: chewing gum negative<br>chewing gum group will not chew gum | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Gastrointesitinal function | Gastrointesitinal function will be assess by bowel sound for every 2 hours and time of flatulence will be recorded | postoperative first 48 hours | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
intestinal function, chewing gum
Comparison of Conventional and Custom Photorefractive Keratectomy (PRK)

Study Overview
=================
Brief Summary
-----------------
The study objective is to compare the clinical outcomes using wavefront guided PRK with iris registration and conventional laser PRK using FDA-approved laser technology on the same patient.

Detailed Description
-----------------
Patients undergoing bilateral PRK on the same day will have one eye randomly assigned to custom wavefront guided PRK and the fellow eye treated with conventional PRK.

Official Title
-----------------
Comparison of Conventional and Custom With Iris Registration PRK Ablations: Assessment of Visual Function and Patient Satisfaction

Conditions
-----------------
Myopia

Intervention / Treatment
-----------------
* Procedure: Custom PRK with iris registration
* Procedure: Conventional PRK


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients deemed to be suitable candidates for bilateral PRK Exclusion Criteria: Patients desiring monovision correction rather than bilateral distance correction

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: 1<br> | Procedure: Custom PRK with iris registration<br>* PRK<br>|
| Active Comparator: 2<br> | Procedure: Conventional PRK<br>* PRK<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Visual acuity |  | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Manifest refraction |  | 6 months | 
| Wavefront aberration value |  | 6 months |
School Intervention Study of Nutrition, Wellbeing and Dental Health

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate the effects of an intervention programme on dietary intake and dental health of 8th grade students.

Official Title
-----------------
School Intervention Study of Nutrition, Wellbeing and Dental Health

Conditions
-----------------
Oral Health, Eating

Intervention / Treatment
-----------------
* Behavioral: dietary counseling
* Dietary Supplement: xylitol


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 7th grade students from the participating schools, written informed consent both from the student and the parent

Ages Eligible for Study
-----------------
Minimum Age: 13 Years
Maximum Age: 14 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: dietary counseling|Various activities and materials for teachers, students, parents and school catering personnel aiming at increasing their awareness and knowledge of good nutrition.|
|Dietary Supplement: xylitol|Delivery of xylitol lozenges (about 1 g xylitol/student/school day) and guidance on tooth brushing.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Dietary intake (eg. sugar, fibre). The presence of active initial caries lesions. |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Nutritional quality of school meals and snacks. Laser fluorescence values of the occlusal surfaces of permanent molar and premolar teeth. |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Eating, Food Habits, Adolescent, Dental Research
Influence of Corticoids on Renal Function in Cardiac Surgery

Study Overview
=================
Brief Summary
-----------------
Hypothesis: Corticoid treatment in cardiac surgery works renal protective. Study design: Randomized, double blind trial in which one group of patients will receive methylprednisolone and the other group (control) will receive placebo NaCl 0.9%.

Official Title
-----------------
Influence of Corticoids on Renal Function in Cardiac Surgery

Conditions
-----------------
Elective Cardiac Surgery

Intervention / Treatment
-----------------
* Drug: Methylprednisolone
* Drug: Placebo


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age between 20-80 year patients scheduled for elective cardiac surgery. preoperative creatinine levels of < 2mg/dl no corticoid treatment Exclusion Criteria: non-elective surgery patiënts with renal dysfunction: creatinine > 2mg/dl patiënts treated with corticoids

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>methylprednisolone | Drug: Methylprednisolone<br>* Methylprednisolone<br>|
| Placebo Comparator: 2<br>Placebo (NaCl 0.9%) | Drug: Placebo<br>* Placebo (NaCl 0.9%)<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Renal dysfunction and renal failure postoperatively in cardiac surgery |  | within 48 hours after cardiac surgery |
The Association of Gut Microbiota With COVID 19 Infection in Children

Study Overview
=================
Brief Summary
-----------------
Although COVID-19 infects gastrointestinal tissues, little is known about the roles of gut commensal microbes in susceptibility to and severity of infection. The investigators will analyze the alterations in fecal microbiomes of patients with COVID-19 infection during hospitalization.

Official Title
-----------------
The Association of Gut Microbiota With Early Infection Stages of COVID-19 in Children

Conditions
-----------------
Coronavirus Infections, Gut Microbiome, Childhood ALL

Intervention / Treatment
-----------------
* Diagnostic Test: 16S rRNA sequencing


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients infected with COVID 19 Exclusion Criteria: congenital heart, renal, intestinal disease malignancy immunologic disease

Ages Eligible for Study
-----------------
Minimum Age: 3 Months
Maximum Age: 15 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patient with COVID 19<br>Pediatric patient infected by COVID 19 | Diagnostic Test: 16S rRNA sequencing<br>* Fecal microbiome analysis using 16S rRNA sequencing<br>|
| Pediatric patient without infection of COVID 19<br>Pediatric patient without infection of COVID 19 | Diagnostic Test: 16S rRNA sequencing<br>* Fecal microbiome analysis using 16S rRNA sequencing<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The analysis of fecal microbiome of patient with COVID 19 | The analysis of fecal microbiome of patient with COVID 19, using 16S rRNA sequencing | through study completion, an average of 1 year |
NGS for Non-unions

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to investigate the role of genetic testing to look for possible infection as a cause for failure of non-healing fractures. The study aims to compare the results of genetic testing known as NGS to standardized clinical laboratory tests for diagnosing infections to see if NGS may be a better diagnostic tool.

Official Title
-----------------
What is the Role of Next-generation Sequencing in Non-union of Orthopaedic Cases

Conditions
-----------------
Nonunion of Fracture

Intervention / Treatment
-----------------
* Diagnostic Test: Next-generation sequencing of swabs collected during surgery


Participation Criteria
=================
Eligibility Criteria
-----------------
Investigational group: Inclusion: Patients undergoing open biopsy / surgical intervention for nonunion following a traumatic (open or closed) long bone fracture (femur shaft, tibia, humerus) which was initially treated operatively.Inclusion Criteria: Nonunions will be defined as a failure to progress towards expected union within an anticipated timeframe, and this judgment will be made by the attending caring for each patient. No specific timeframe or arbitrary cut points will be defined to allow for the considerable variation in fracture healing and different anatomical sites. Presumed Septic and Aseptic nonunions >18 years old and able to provide informed consent Exclusion Criteria: Exclusion: Pathological fractures at index injury Patients on antibiotic therapy <2 weeks prior to surgery INCLUSION/ EXCLUSION CRITERIA FOR CONTROL GROUP: Inclusion: Patients undergoing surgical intervention for nonunion following a traumatic closed long bone fractures (femur shaft, tibia, humerus) >18 years old and able to provide informed consent Exclusion: Pathological fractures at index injury Patients on antibiotic therapy <2 weeks prior to surgery

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Surgical intervention for non-union<br>The investigation group will consist of cases undergoing surgical intervention for non-union | Diagnostic Test: Next-generation sequencing of swabs collected during surgery<br>* Traditional swabs for culturing as well as swabs for NGS testing will be collected<br>|
| Acute fracture fixation<br>The control group will consist of cases undergoing acute fracture fixation | Diagnostic Test: Next-generation sequencing of swabs collected during surgery<br>* Traditional swabs for culturing as well as swabs for NGS testing will be collected<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Treatment failure | Need for additional re-operation or intervention within follow-up period | 6 months post-op |
Relationship Between Central Corneal Thickness and Intraocular Pressure Measures Instruments.

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate the relationship between intraocular pressure and central corneal thickness using various instruments in ocular hypertension, normal-tension glaucoma, primary open angle glaucoma, keratoconus and normal eyes.

Detailed Description
-----------------
The purpose of this study is to evaluate the relationship between intraocular pressure and ultrasound pachymetry measured central corneal thickness using Goldman tonometry and PASCAL instruments. Patient groups examined include: ocular hypertensives normal-tension glaucoma primary open angle glaucoma keratoconus control normal eyes

Official Title
-----------------
Phase 4 Study Evaluating the Relationship Between Intraocular Pressure and Central Corneal Thickness Using Various Instruments in Ocular Hypertension, Normal-tension Glaucoma, Primary Open Angle Glaucoma, Keratoconus and Normal Eyes.

Conditions
-----------------
Glaucoma, Glaucoma, Open Angle, Ocular Hypertension, Keratoconus

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adults over the age of 18 years Clinical diagnosis of glaucoma, open angle; ocular hypertension; glaucoma (low-tension); keratoconus and other healthy volunteers. Exclusion Criteria: Children under the age of 18 years Adults with learning disabilities Adults who are unconscious or severely ill Adults who have known terminal illness Adults in emergency situations Adults with dementia Prisoners Young offenders Those who could be considered to have a dependant relationship with the investigator (i.e. those in care homes or medical students) Other vulnerable groups

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Corneal thickness, Intraocular pressure, Instrumentation, Glaucoma, Keratoconus