Evaluation of Periodontal Diseases and Obesity in Women

Study Overview
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Brief Summary
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The aim of this study was to evaluate the effect of obesity and exercise on periodontal and biochemical parameters [serum, saliva and gingival crevicular fluid (GCF) adipokines (interleukin-1β, tumor necrosis factor-α, leptin, resistin and adiponectin)].

Detailed Description
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It is thought that adipokines may play a role on periodontal disease in obese subjects, periodontal disease may also aggravate the existing systemic disease by changing the inflammatory parameters in the body. The aim of this study was to evaluate the effect of obesity and exercise on periodontal and biochemical parameters [serum, saliva and gingival crevicular fluid (GCF) adipokines (interleukin-1β, tumor necrosis factor-α, leptin, resistin and adiponectin)].

Official Title
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The Effects of Obesity and Periodontitis on Biochemical Parameters in Women Subjects

Conditions
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Periodontal Diseases, Obesity

Intervention / Treatment
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* Other: Exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Being women, Older than 18 yrs old, Not being pregnant, Not being disabled, For study group; being obese, not for healthy group being systemically health and in normal weight Not treated periodontological in the last 6 months Exclusion Criteria: Younger than 18 yrs old, Smokers who smokes more than 10 cigarettes in a day, Uncontrolled systemic diseases, Having periodontal treatment who needs antibiotic prophylaxis
Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Obese women<br>Obese women who participated exercise programme. | Other: Exercise<br>* This group made exercise for 12 week/3 times a week.<br>|
| No Intervention: Normal weighted<br>Normal weighted women with non-periodontitis | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Biochemical variables GCF | TNF-A, IL-1B,concentrations levels (pg/µl) | 12 week | 
| Biochemical variables GCF | Leptin, adiponectin, resistin concentrations levels (ng/µl) | 12 week | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Biochemical variables_Saliva | TNF-A, IL-1B,concentrations levels (pg/µl) | 12 week | 
| Biochemical variables_Saliva | leptin, adiponectin, resistin concentrations levels (ng/µl) | 12 week | 
| Biochemical variables_Serum | TNF-A, IL-1B,concentrations levels (pg/µl) | 12 week | 
| Biochemical variables_Serum | leptin, adiponectin, resistin concentrations levels (ng/µl) | 12 week | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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obesity, periodontal diseases, gingival crevicular fluid, saliva, serum