Comparing Effectiveness of Merocel and Packing With Tranexamic Acid in the Management of Anterior Epistaxis

Study Overview
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Brief Summary
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Aim of this study is evaluate whether superior nasal compression with tranexamic acid to simple nasal compression and Merocel packing. In this study, patients who presented with non-traumatic anterior epistaxis to emergency departments will be included in this study. Three different therapy option are created; first, nasal compression with tranexamic acid, second, simple nasal compression without any drugs. And third, packing with Merocel.

Official Title
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The Evaluation of Effectiveness of Nasal Compression With Tranexamic Acid Compared to Simple Nasal Compression and Merocel Packing

Conditions
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Tranexamic Acid, Epistaxis, Nasal Packing

Intervention / Treatment
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* Drug: Tranexamic Acid
* Drug: Normal saline
* Device: Merocel


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with anterior epistaxis older than 18 year and accept to participate in the study Exclusion Criteria: Patients younger than 18 years Patients who used anticoagulation therapy Patients who have hemodynamically instability Traumatic epistaxis Patients who have known bleeding disorder

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Tranexamic acid group<br>500mg tranexamic acid is sprayed in the nose by atomizer spray, and then is applied nasal compression by manually. | Drug: Tranexamic Acid<br>* 500mg tranexamic acid is sprayed in the nose by atomizer spray, and then is applied nasal compression by manually.<br>|
| Placebo Comparator: Placebo group<br>5ml normal saline is sprayed in the nose by atomizer spray, and then is applied nasal compression by manually. | Drug: Normal saline<br>* 5 cc normal saline is sprayed in the nose by atomizer spray, and then is applied nasal compression by manually.<br>|
| Active Comparator: Merocel Group<br>Merocel packing is applied. | Device: Merocel<br>* Merocel packing is applied.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Success rate of interventions to stop bleeding | Percentages of numbers of patients who have stopped bleeding within first 15 minutes after nasal compression or Merocel packing | First 15 minutes | 
| Numbers of patients who needs rescue treatment | In patients who have unstoppable epistaxis within 15 minutes, Merocel packing will be applied as a rescue treatment. Numbers of these patients will be recorded. | After 15 minutes first intervention method. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Re-bleeding | Frequency of re-bleeding within first 24 hours. | 24 hour |