Effect of Esophageal Contractile Reserve on Changes in Esophageal Motility and Symptoms After ARS in Patients With GERD

Study Overview
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Brief Summary
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rapid swallow (MRS) can assess the contractile reserve capacity of the oesophageal body and identify and diagnose oesophageal motility disorders, but the impact of preoperative oesophageal reserve capacity on postoperative symptoms and motility in patients with GERD remains unclear. The aim of this study was to assess the effect of pre-operative oesophageal reserve capacity on post-reflux symptoms and motility in patients with GERD by using a high-resolution oesophageal manometry-based provocation test, MRS, to track pre-operative ineffective oesophageal motility (IEM).

Detailed Description
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Lower oesophageal sphincter relaxation is an important cause of GERD and ineffective oesophageal motility may be associated with GERD, but the mechanism of oesophageal corporal motility disorders is unclear. High-resolution manometry (HRM) has shown to be more accurate than conventional manometry in assessing oesophageal motility, and can provide guidance for GERD surgery. The aim was to conduct a cohort study to investigate the yu'h of patients with preoperative esophageal motility disorders with or without esophageal reserve, based on the assessment of esophageal motility by high-resolution esophageal manometry to follow up changes in esophageal motility and symptoms in patients after anti-reflux surgery.

Official Title
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Effect of Esophageal Contractile Reserve on Changes in Esophageal Motility and Symptoms After Anti-reflux Surgery in Patients With Gastroesophageal Reflux Disease

Conditions
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Esophageal Motility Disorders

Intervention / Treatment
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* Other: Follow-up visits


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age over 18 years old Patients to be treated surgically for gastroesophageal reflux disease Ineffective esophageal motility diagnosed by high resolution esophageal manometry according to Chicago Classification version 4.0 Obtaining Informed Consent Exclusion Criteria: Previous other upper gastrointestinal surgery Pregnant women and other people with contraindications to surgery and tests Other specifically defined esophageal motility disorders, such as nutcracker esophagus

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| IEM in patients with GERD with normal MRS contraction<br>Esophageal motility determined by high resolution esophageal manometry and multiple rapid swallow (MRS) tests | Other: Follow-up visits<br>* Regular follow-up visits to record information about the patient's surgery and routine post-operative examinations<br>* Other names: Questionnaire to assess symptoms and quality of life etc.;|
| IEM in patients with GERD with abnormal MRS contraction<br>Esophageal motility determined by high resolution esophageal manometry and multiple rapid swallow (MRS) tests | Other: Follow-up visits<br>* Regular follow-up visits to record information about the patient's surgery and routine post-operative examinations<br>* Other names: Questionnaire to assess symptoms and quality of life etc.;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Effect of changes in oesophageal motility after anti-reflux surgery compared to pre-surgery | Using high resolution manometry to assess changes in oesophageal motility after anti-reflux surgery, compared to pre-surgery. | 2 year follow-up after anti-reflux surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Effect of changes of post-anti-reflux surgery symptoms | Reflux Symptom Questionnaire Assessment to assess the changes of symptoms | 2 year follow-up after anti-reflux surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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contraction reserve