Follow up After Survived Therapy With Mild Induced Hypothermia (MIH) After Restoration of Spontaneous Circulation (ROSC)

Study Overview
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Brief Summary
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Sudden cardiac arrest (SCA) remains one of the major leading causes of death. Cognitive deficits are common in survivors of SCA. Postresuscitative mild induced hypothermia (MIH) lowers mortality and reduces neurologic damage after cardiac arrest. The investigators evaluated the long term neurological outcome after mild hypothermia after restoration of spontaneous circulation.

Detailed Description
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Consecutive patients with restoration of spontaneous circulation (ROSC) after resuscitation due to out-of-hospital SCA, admitted to our intensive care unit, underwent MIH. Hypothermia was induced by infusion of cold saline and whole-body-cooling methods (electronic randomization: invasive Coolgard or non-invasive ArcticSun). The core body temperature was operated at 32 to 34 °C over a period of 24 hours followed by active rewarming. Neurological status was evaluated at hospital discharge and 6 months after discharge using the Pittsburgh Cerebral Performance Category (CPC).

Official Title
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Neurological Outcome After Mild Induced Hypothermia (MIH) After Restoration of Spontaneous Circulation

Conditions
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Cardiac Arrest, Hypothermia

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: survived cardiac arrest voluntary consent Exclusion Criteria: no voluntary consent

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| COOL<br>Patients after therapy with mild hypothermia | |
| UnCool<br>Patients without therapy with mild hypothermia due to non-operational cooling-devices | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Neurological outcome after 6 month after MIH, Quality of life-survey | Neurological outcome after 6 month after MIH measured by questionnaire. | 6 Month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Managing daily activities | Managing daily activities after 6 month after tMIH measured with a questionnaire. | 6 Month | 
| Surviving after hospitalization | Surviving after hospitalization after MIH | 6 Month | 
| Neurological outcome depending of the beginning of MIH | Neurological outcome depending of the beginning of MIH | 6 month | 
| Neurological Outcome in consideration of the practice of the treating instances. | Neurological outcome in consideration of the practice of the treating instances after restoration of spontanous circulation measured with a questionnaire. | 6 month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Sudden cardiac arrest, hypothermia, neurological outcome