POCD: Correlations With the Gene Polymorphism and the Concentrations of Plasma Homocysteine, Folic Acid and Vitamin B12.

Study Overview
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Brief Summary
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To study on the Postoperative Cognitive Dysfunction: Correlations With the Gene Polymorphism and the Concentrations of Plasma Homocysteine, Folic Acid and Vitamin B12. To explore whether the gene polymorphism and the concentrations of plasma homocysteine, folic acid and vitamin B12 could be used as predictor(s) of POCD and to provide reference for POCD prevention, early detection and timely diagnosis and treatment.

Official Title
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Postoperative Cognitive Dysfunction: Correlations With the Gene Polymorphism and the Concentrations of Plasma Homocysteine, Folic Acid and Vitamin B12.

Conditions
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Postoperative Cognitive Dysfunction

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Non-cardiac surgery patients; Age is greater than or equal to 60 years old; Han Nationality, mother tongue is chinese; The MMSE score: Illiteracy is greater than or equal to 17 points, primary school is greater than or equal to 20 points, higher secondary school is more than 24 points; The Geriatric Depression Scale (GDS) grade 1 or 2; The important function without serious heart, brain, liver, kidney, lung and other organs; The ASA class I or II; The people signed informed consent. Exclusion Criteria: The diagnosis of neurological and psychiatric disorders, such as Alzheimer's disease, Parkinson's syndrome, multiple sclerosis, schizophrenia, depression, etc.; Had severe head and face disease, trauma history or history of surgery; The serious body disease and tobacco, wine and other substance abuse history; The presence of malignant tumor with shorter survival disease.

Ages Eligible for Study
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Minimum Age: 60 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| study group<br>215 Male and female patients undergoing non-cardiac surgery at the Affiliated Hospital of Xuzhou Medical University [Jiangsu China]. The investigators do the Mini-Mental score examination (MMSE) and neuropsychological tests 1 day before (baseline) and 1 week after surgery without safety issue. Patients will be divided into POCD and non-POCD groups according to the two times tests. | |
| non-surgical group<br>The investigators enroll 30 healthy volunteers and do the Mini-Mental score examination (MMSE) and neuropsychological tests at 1 day (baseline) and1 week without safety issue. The exclusive purpose of the non-surgical group is to aid in the POCD calculation according to the ISPOCD 1 study definition. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the neuropsychological tests | the neuropsychological tests to measure cognitive function, including the Trail Making Test, the Grooved Pegboard Test, the Digit Span Test, the Number-Symbol Replacement Test,the Finger Tapping Test, the Word Fluency Test and the Building Block Test. | 1 day before surgery(baseline) | 
| Mini-Mental score examination [MMSE] | Mini-Mental score examination [MMSE] used for screening of dementia | 1 day before surgery(baseline) | 
| the neuropsychological tests | the neuropsychological tests to measure cognitive function, including the Trail Making Test, the Grooved Pegboard Test, the Digit Span Test, the Number-Symbol Replacement,the Test Finger Tapping Test, the Word Fluency Test and the Building Block Test. | within the first 7 days (plus or minus 2 days) after surgery | 
| Mini-Mental score examination [MMSE] | Mini-Mental score examination [MMSE] used for screening of dementia | within the first 7 days (plus or minus 2 days) after surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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non-cardiac surgery, Postoperative Cognitive Dysfunction