Effects of Combined Grape Seed Extract and L-citrulline Supplementation on Hemodynamic Responses in Young Males

Study Overview
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Brief Summary
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This study was to examine the additive benefits with combined grape seed extract (GSE) and L-citrulline supplementation on hemodynamic responses to dynamic exercise, 11 young, healthy males were recruited for this study.

Detailed Description
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The investigators aimed the additive effects of combined grape seed extract (GSE) and L-citrulline supplementation on hemodynamic responses to dynamic exercise, 11 young, healthy males were recruited for this study. Effects of 7 days of combined GSE with L-citrulline supplementation on systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial blood pressure (MAP), cardiac output (CO), total vascular conductance (TVC), and oxygen consumption (O2) were examined at rest and during cycling exercise.

Official Title
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Effects of Combined Grape Seed Extract and L-citrulline Supplementation on Hemodynamic Responses in Young Males

Conditions
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Dietary Supplementation

Intervention / Treatment
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* Dietary Supplement: Grape seed extract
* Dietary Supplement: Placebo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: healthy males Exclusion Criteria: cardiovascular and/or pulmonary disease, musculoskeletal disorders, or medications that prevent the safe completion of the exercise protocol

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 30 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Randomized double blind grape seed extract design<br>Grape see extract | Dietary Supplement: Grape seed extract<br>* Effects of 7 days of combined GSE with L-citrulline supplementation on hemodynamic responses at rest and during cycling exercise.<br>Dietary Supplement: Placebo<br>* Effects of 7 days of placebo supplementation on hemodynamic responses at rest and during cycling exercise.<br>|
| Placebo Comparator: Randomized double blind placebo design<br>Placebo | Dietary Supplement: Grape seed extract<br>* Effects of 7 days of combined GSE with L-citrulline supplementation on hemodynamic responses at rest and during cycling exercise.<br>Dietary Supplement: Placebo<br>* Effects of 7 days of placebo supplementation on hemodynamic responses at rest and during cycling exercise.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Systolic blood pressure (mmHg) | by sphygmomanometer | 7 days | 
| Diastolic blood pressure (mmHg) | by sphygmomanometer | 7 days | 
| Mean arterial pressure (mmHg) | calculated (MAP = (SBP-DBP)/3 + DBP | 7 days | 
| Heart rate (bpm) | measured using Physio Flow (non-invasive device) | 7 days | 
| Stroke volume (ml) | measured using Physio Flow (non-invasive device) | 7 days | 
| Cardiac output (l/min) | calculated: HR (bpm) x SV (ml) | 7 days | 
| Total vascular conductance (ml/min/mmHg) | calculated: CO (ml/min) / MAP (mmHg) | 7 days |