Integrating Systematic Data of Geriatric Medicine to Explore the Solution for Health Aging

Study Overview
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Brief Summary
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This project aims to build up the comprehensive database of geriatric medicine for local Taiwanese.

Detailed Description
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This project is the pilot for the basis of establishing the schema of database and efficient procedures including subject recruitment, specimen collection, management, and measurement of samples obtained from multiple sources. We will focus on deciphering the correlation of sleep quality and the integrity of brain structure by integrating the holistic health data, socio-demographic characteristics, MRI, wearable technique, and laboratory technology including clinical lab, genotyping, metabolomics, gut microbiome, to unravel the clinical feature of which the age will effect on the frequency of sleep disturbance. This project will not only systematically study the aging effect on the sleep quality and brain structure integrity, but pave the way for exploring a variety of aging-related indications.

Official Title
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Integrating Systematic Data of Geriatric Medicine to Explore the Solution for Health Aging

Conditions
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Sleep Disturbance, Cognitive Change, Aging

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Participants of annual health checkup conducted by either Taipei city or Chang Gung Health and Culture Village. aged ≧ 60 years old. have medical record in Chang Gung Memorial Hospital. resided in the Taiwan area over 180 days in past one year. Exclusion Criteria: Participants with the medical history of severe organ disorders, severe autoimmune disease, or cancer under treatment. Contraindications or previously failure for receiving brain computerized tomography or magnetic resonance imaging scan. Participants who had receive outpatient clinic follow-ups with diseases that may affect the cognitive evaluation or presentation. Depression with ongoing diagnosis and treatment, suicide idea or suicide behavior in the past 6 months. Difficulty in communication or disabilities

Ages Eligible for Study
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Minimum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The brain volume of local Taiwanese aged over 60 years old | Measure the volume of cerebrum, cerebellum, and skin of skull (unit in mm3) by magnetic resonance imaging (MRI) | one hour | 
| The monitoring of sleep-related events of local Taiwanese aged over 60 years old | Measure the sleep stages (unit in minute), apnea-hypopnea index (unit in counts/hour), and respiratory events by polysomnography | one night | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The actigraphy of local Taiwanese aged over 60 years old | Measure the circadian rhythm (unit in minute) by Actiwatch | two weeks | 
| The neurocognitive questionnaire of local Taiwanese aged over 60 years old | Measure the neurocognitive condition and sleep quality as assessed by GDS-15, UCLA-LS, HAM-A, HAM-D, AES, TSII, CTQ, AD8, MMSE, ECog, CERAD-NAB, PSQI, ESS, SOS, and STOP-Bang | one day | 
| The gut microbiota of local Taiwanese aged over 60 years old | Assess the gut bacterial diversity and profile by stool analysis | one day | 
| The metabolism of local Taiwanese aged over 60 years old | Measure the metabolites as biomarkers by urine and blood analysis | one day | 
| The polysomnographic recording for elderly with obstructive sleep apnea (OSA) | Subjects with OSA will undergo continuous positive airway pressure (CPAP) and evaluate the improvement rate (unit in percent) by polysomnography and sleepiness questionnaire | three months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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dementia, depression, brain structure, system biology