The Effect of Age on the Hemodynamic Response During Rest and Exercise in Healthy Humans

Study Overview
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Brief Summary
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Primary: To observe how hemodynamic parameters are affected by age during rest and exercise in healthy humans. Furthermore, how an acute fluid challenge changes hemodynamic parameters. Secondary: To thoroughly examine this population with regard to cardiac performance and function, anthropometrics, metabolic status, exercise capability, constitution, pulmonary status, and humoral markers of organ functions. This population will serve as a healthy control group, to which different populations can be compared, hence the need for a comprehensive characterization. Hypotheses: Diastolic function and parameters associated with diastolic function gradually deteriorate with increasing age. The gradual deterioration is unmasked at an earlier age during exercise and fluid challenge, compared to measurements made at rest.

Official Title
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The Effect of Age on the Hemodynamic Response During Rest and Exercise in Healthy Humans

Conditions
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Hemodynamics

Intervention / Treatment
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* Other: Exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age over 18 years No acute or chronic diseases that can influence hemodynamics Pause in medication with effect on hemodynamics 24h before experimental day Echocardiography, with no structural abnormalities with an impact on hemodynamics. ECG without any pathological findings, including arrhythmia Normal red and white blood count, normal renal, liver, thyroid, immune, and hematological function as well as normal electrolytes, HbA1c and natriuretic peptides Ability to perform graded bicycle exercise testing BMI in the range of 20-30 kg/m2 Height within population mean ±2 standard deviations VO2-max within population mean ±2 standard deviations (age corrected) Acceptable sonographic conditions Informed consent Exclusion Criteria: History of heart failure (verified or suspected), or heart failure verified by pathological left and right systolic and diastolic measurements of the heart Hypotension (systolic blood pressure < 100 mmHg) Inability to participate Pregnant women Diabetes

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Exercise|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Composite of hemodynamic parameters | Invasive measurements using Swan-Ganz catheters and echocardiography will provide the data needed. | minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Composite of humoral markers | Blood samples will be analysed with regard to humoral peptides and hormones that may affect hemodynamics. | up to 1 hour | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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fluid challenge, Cardiac physiology, ageing, gender differences, diastole