Effect of Nanotechnology Structured Water Magnalife for the Prevention of Recurrent Urinary Tract Infections.

Study Overview
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Brief Summary
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This study investigates nanotechnology structured water magnalife in urology and to test its effects against lower urinary tract infections (UTI) in females.

Detailed Description
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This study represents the first time to use nanotechnology structured water magnalife in urology and to test its effects against lower urinary tract infections (UTI) in females. Urinary tract infection (UTI ) is the second most common bacterial infection, affecting women at a much higher frequency than men. There is a higher rate of recurrence of UTI, and a recurrent infection will follow 25-35% of initial UTI episodes within 3-6 months. Intermittent or prolonged low dose antibiotic therapy has been used to treat and prevent recurrent UTI. Emerging of resistance to antimicrobial agents, enormous economic burden, and the side effects of antibiotics have led to the search for an alternative non-antibiotic prophylaxis of recurrent UTI. Nanotechnology structured water is a new type of drinking water that has been prepared using different types of energy fields and electromagnetic fields to produce this structured water, which has new and different characteristics from the ordinary water. In the current study, the efficacy of nanotechnology structured water magnalife was compared with low-dose Trimethoprim and bottled drinking water for the prevention of recurrent UTI.

Official Title
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A Randomized, Double-blind, Placebo-controlled Clinical Study to Assess the Use of Nanotechnology Structured Water Magnalife for the Prevention of Recurrent Urinary Tract Infections.

Conditions
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Recurrent Urinary Tract Infection

Intervention / Treatment
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* Dietary Supplement: Nanotechnology Structured water Magnalife
* Drug: Trimethoprim
* Dietary Supplement: Ordinary bottled drinking water


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ≥ 2 (two or more than two) UTI in the last 6 months ≥ 3 (three or more than three) UTI in the last 12 months Exclusion Criteria: immunotherapy radiotherapy malignancy steroids chronic infections chemotherapy immunosuppressive drugs anatomical abnormality of the urinary tract surgical operation the urinary tract

Ages Eligible for Study
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Minimum Age: 24 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Interventional (Group M)<br>The group of patients given nanotechnology structured water magnalife | Dietary Supplement: Nanotechnology Structured water Magnalife<br>* Nanotechnology Structured water Magnalife is drinking water that has been modified using nanotechnology to change the structuring of water molecules<br>* Other names: 5200250040466;|
| Active Comparator: Control (Group T)<br>The group of patients given Trimethoprim | Drug: Trimethoprim<br>* Antibiotic<br>* Other names: Proloprim;|
| Placebo Comparator: Placebo (Group O)<br>The group of patients given ordinary bottled drinking water | Dietary Supplement: Ordinary bottled drinking water<br>* Placebo<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Recurrent Urinary Tract Infection | Urinalysis by GUE (>10 white blood cells (WBC)/mm3 per high-power field (HPF) Urine culture (urinary pathogen of ≥105 colony-forming units (CFU) per mL) | Twelve months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time to first recurrent UTI | The time since the beginning of the study until the first recurrent UTI (days) | Twelve months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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nanotechnology water, antibiotic prophylaxis, recurrent UTI.