Yoga Intervention for the Improvement of Cancer-Related Stress in Cancer Survivors

Study Overview
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Brief Summary
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This clinical trial develops and test a yoga intervention in improving cancer-related stress in cancer survivors. The online hatha yoga intervention of breathing and movement incorporates both restorative poses, breathing techniques, guided meditation and may reduce stress levels and improve overall quality of health in cancer survivors.

Detailed Description
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PRIMARY OBJECTIVE: I. To develop and test the feasibility of a standardized 12-week online hatha yoga intervention (n=30) of breathing and movement incorporating both restorative poses, breathing techniques, guided meditation. SECONDARY OBJECTIVES: I. To evaluate the yoga intervention in relation to self-reported levels of stress and quality of life in cancer survivors (n=30). II. Feasibility of collecting blood and saliva at baseline and post-intervention for stress biomarkers, including cortisol and norepinephrine. EXPLORATORY OBJECTIVE: I. To determine how behavior change, quality of life (QoL), and biomarkers of adrenergic stress, inflammation, and immunosuppression are affected by a 12-week online yoga program completed by cancer survivors. OUTLINE: Patients receive online yoga intervention once a week (QW) for 12 weeks. After completion of study, patients are followed up at 3 months.

Official Title
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Influence of Yoga on Cancer-Related Stress in Cancer Survivors

Conditions
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Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm

Intervention / Treatment
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* Other: Quality-of-Life Assessment
* Other: Survey Administration
* Other: Yoga


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age >= 18 years of age Have been diagnosed with a cancer and have finished treatment Have been cleared for physical activity by a physician or nurse practitioner (physician or nurse practitioner name and date clearance received) Participant must understand the investigational nature of this study and sign an Independent Ethics Committee/Institutional Review Board approved written informed consent form prior to receiving any study related procedure Exclusion Criteria: Unwilling or unable to complete the assessment in English Are pregnant or nursing Are unwilling or unable to follow protocol requirements Have skeletal instabilities and/or cardio-pulmonary comorbidities Have any condition which in the investigator's opinion deems the subject an unsuitable candidate to participate in this study

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Supportive care (yoga)<br>Patients receive online yoga intervention QW for 12 weeks. | Other: Quality-of-Life Assessment<br>* Ancillary studies<br>* Other names: Quality of Life Assessment;Other: Survey Administration<br>* Ancillary studies<br>Other: Yoga<br>* Receive yoga intervention<br>* Other names: Yoga Therapy;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Proportion of subjects who participate or show high adherence to the intervention | Will be presented as observed proportion and 95% Clopper-Pearson confidence intervals (CIs). | Up to 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Efficacy of the intervention in stress-reduction | Serum cortisol and norepinephrine levels will be measured by blood collection | Up to 3 months post-intervention | 
| Efficacy of the intervention in stress-reduction | Self report stress | Up to 3 months post intervention | 
| Efficacy of the intervention in stress reduction | salivary cortisol will be measured by saliva collection | Up to 3 months post intervention |