Physical Recovery After Laparoscopic vs. Open Liver Resection

Study Overview
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Brief Summary
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The role of laparoscopic liver surgery with respect to clinical outcome remains unclear.

Detailed Description
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The role of laparoscopic liver surgery with respect to clinical outcome remains unclear. The investigators hypothesized that laparoscopic liver resection (LLR) is associated with better postoperative recovery than open liver resection (OLR). Twenty-one patients who underwent LR were included in this study (11 OLR (52.4%) and 10 LLR (47.6%), respectively). Postoperative recovery was measured by bicycle stress testing at months 1 and 6 after surgery and compared to preoperative stress testing. Standardized performance for bicycle stress testing was calculated based on age, sex, height and weight. Postoperative recovery was compared between groups as change of performance (%).

Official Title
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Physical Recovery After Laparoscopic vs. Open Liver Resection - a Pilot Trial

Conditions
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Postoperative Complications, Liver Diseases, Physical Stress, Surgery

Intervention / Treatment
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* Other: Ergometry


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: all patients undergoing liver resection (open vs. laparoscopic) all patients willing participate and gave written informed consent Exclusion Criteria: pregnancy significant traumatic injury within 30 days prior to study enrolment inability or unwillingness to comply to the protocol or to perform bicycle ergometry
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: non-randomized cohort study, 2 parallel groups
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: laparoscopic liver resection<br>Patients undergoing laparoscopic liver resection | Other: Ergometry<br>* Patients underwent a preoperative ergometry to assess their physical fitness prior to their planned liver resection. Bicycle stress testing was performed preoperatively and 1 and 6 months postoperatively.<br>|
| Active Comparator: open liver resection<br>Patients undergoing open liver resection | Other: Ergometry<br>* Patients underwent a preoperative ergometry to assess their physical fitness prior to their planned liver resection. Bicycle stress testing was performed preoperatively and 1 and 6 months postoperatively.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overall change in performance | The change in performance after 1 and 6 months postoperatively in comparison to preoperative ergometry. | 1, 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative Complications | Secondary endpoints included postoperative complications (wound healing, liver failure, adverse events) | 1 months | 
| Liver resection and effect on postoperative fitness | patients were divided into two groups ( major (>2 segments) vs. minor (≤2segments) liver resection) and postoperative performance was evaluated | 2 years | 
| length of stay | Length of postoperative hospital stay | 1 month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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laparoscopic, minimal invasive, physical recovery, liver surgery