Two- Dimensional Speckle Tracking Echocardiography After Primary Percutaneous Coronary Intervention

Study Overview
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Brief Summary
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ST-segment elevation myocardial infarction (STEMI) is a major cause of morbidity and mortality worldwide. In spite of decrease in acute and long-term mortality following STEMI in parallel with more use of reperfusion therapy, such as primary percutaneous coronary intervention (PPCI), modern antithrombotic therapy, and secondary prevention, mortality remains considerable. Reduced EF is a well-known predictor of increased short and long term major adverse cardiovascular events MACE :( heart failure, stroke and death)

Official Title
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The Role of Two- Dimensional Speckle Tracking Echocardiography in Prediction of Remodeling and Major Adverse Cardiovascular Events in ST Elevation Myocardial Infarction After Primary Percutaneous Coronary Intervention

Conditions
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Myocardial Infarction

Intervention / Treatment
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* Procedure: 2D speckle tracking echocardiography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ST elevation myocardial infarction patients after primary percutaneous coronary intervention Exclusion Criteria: Previous myocardial infarction. Sever or haemodynamically significant (associated with chamber dilation) valvular heart diseases. Previous heart failure. Previous cerebrovascular strokes. Atrial fibrillation. Severe comorbidities as severe renal impairment, hepatic or respiratory failure. Bad equality views which affects accurate speckle tracking imaging.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Study group<br>ST elevation myocardial infarction (STEMI) patients after primary percutaneous coronary intervention who will be followed up in Assiut University hospital. | Procedure: 2D speckle tracking echocardiography<br>* Global and segmental strain and strain rate in longitudinal and circumferential directions will be detected after PPCI; before discharge. The LV circumferential strains and strain rates will be determined from the short-axis views at the basal, middle, and apical levels, and longitudinal strains and strain rates will be determined from the apical 2-, 3-, and 4-chamber views of the LV. Segmental longitudinal strains equal to -15% or closer to 0 will be considered abnormal (injured segments). The average segmental longitudinal strain and strain rate of the abnormal segments is defined as the injury longitudinal strain (InjLS) and injury longitudinal systolic strain rate (InjLSRs).<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The Incidence of major adverse cardiovascular events | the rate of Acute coronary syndrome, Heart failure, Stroke and all-cause mortality | 1 year |