Emotion and Cognitive Function and Brain Imaging Change in HD Patients

Study Overview
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Brief Summary
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Observe the influence of entering hemodialysis treatment on the emotional and cognitive functions of ESRD patients. Observe the influence of entering hemodialysis treatment on the brain structure imaging of ESRD patients. Analyze and study the relevant clinical risk factors of the above-mentioned effects, and find targets for therapeutic intervention.

Detailed Description
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Select uremic patients and maintenance hemodialysis patients admitted to the Central Dialysis Room of Beijing Friendship Hospital, Capital Medical University from 2021, to collect and sort out the demographic characteristics of the patients: gender, age, clinical characteristics: primary disease, complications and Complications, body mass index (BMI), residual renal function, etc., clinical examination indicators: hemoglobin, blood calcium, blood phosphorus, blood PTH, blood albumin, URR, etc., hemodialysis treatment parameters: dialysis mode, dialyzer model, vascular access , Blood flow, etc., record the patient's emotional and cognitive function status, various clinical indicators and changes in the patient's quality of life before and after the start of treatment, and use multimodal magnetic resonance neuroimaging research sequences to analyze the changes in the patient's brain structure and function.

Official Title
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Study on the Changes of Emotion and Cognitive Function and Brain Imaging in Uremic Patients Before and After Entering Dialysis

Conditions
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Kidney Failure, Chronic, Cognitive Dysfunction, Magnetic Resonance Imaging

Intervention / Treatment
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* Other: This is an observational study


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients who are new to hemodialysis treatment, and those who are on regular hemodialysis treatment for ≥6 months. Age ≥ 18 years old. Exclusion Criteria: There was already a severe central nervous system disease before dialysis. Hearing and visual impairment cannot communicate or cooperate. Mental illness and incapacity. The magnetic resonance examination could not be completed for various reasons. Life expectancy with serious diseases is less than 6 months.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Newly HD patients<br>Newly admitted patients with uremia who started hemodialysis treatment | Other: This is an observational study<br>* This is an observational study<br>|
| MHD patients<br>Maintenance hemodialysis patients | Other: This is an observational study<br>* This is an observational study<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Appears obvious emotional and cognitive decline, or abnormal head MRI | Appears obvious emotional and cognitive decline, or abnormal head MRI | 2 years |