Evaluation of Cerebral Oxygenation and Hemodynamics in Patients With Cerebral Venous Thrombosis

Study Overview
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Brief Summary
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Cerebral hypoperfusion and hypoxia are the major determinants of neurological outcomes following acute brain injury as proved in Traumatic Brain Injury/Sub Arachnoid Haemhorrhage literature. How the brain injury affects cerebral oxygenation in patients with CVT is not currently known. Some of the factors that can affect cerebral oxygenation in patients with CVT are Hemoglobin, PO2, PCO2, Cerebral Perfusion Pressure (or MAP) and change in Intracranial Pressure after Decompressive Craniectomy. This study is designed to study how these factors affect cerebral oxygenation and impact of Decompressive Craniectomy on the cerebral oxygenation.

Official Title
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Evaluation of Cerebral Oxygenation and Hemodynamics in Patients With Cerebral Venous Thrombosis

Conditions
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Cerebral Venous Thrombosis

Intervention / Treatment
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* Device: NIRS based Cerebral Oximetry


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: -Patients diagnosed with cerebral venous thrombosis, undergoing decompressive craniectomy. Exclusion Criteria: Patients on inotropic support Systolic blood pressure < 90 mmHg Haemoglobin oxygen saturation <95% Refusal of consent Age <16 and > 65 years Known history of diabetes or hypertension Pregnancy Any contraindication for application of cerebral oximetry sensors

Ages Eligible for Study
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Minimum Age: 16 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: NIRS based Cerebral Oximetry|Cerebral Oximetric measurement before and after decompressive craniectomy|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ipsilateral Regional Cerebral Oxygen Saturation | Measurement of regional cerebral oxygen saturation over ipsilateral frontal lobe before and after decompressive craniectomy with follow up at postoperative 24 and 48 hours. | From Recruitment till 48 hours postoperative (end of study) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Contralateral Regional Cerebral Oxygen Saturation | Measurement of regional cerebral oxygen saturation over contralateral frontal lobe before and after decompressive craniectomy with follow up at postoperative 24 and 48 hours. | From Recruitment till 48 hours postoperative (end of study) | 
| Systolic Blood Pressure | Measurement of systolic blood pressure before and after decompressive craniectomy with follow up at postoperative 24 and 48 hours. | From Recruitment till 48 hours postoperative (end of study) | 
| Glasgow coma scale score | Measurement of Glasgow coma scale score before and after decompressive craniectomy with follow up at postoperative 24 and 48 hours. | From Recruitment till 48 hours postoperative (end of study) | 
| Arterial blood gas measurement | Arterial blood gas measurement before and after decompressive craniectomy with follow up at postoperative 24 and 48 hours. | From Recruitment till 48 hours postoperative (end of study) | 
| Haemoglobin | Haemoglobin measurement before and after decompressive craniectomy with follow up at postoperative 24 and 48 hours. | From Recruitment till 48 hours postoperative (end of study) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cerebral Oximetry, Cerebral Venous Thrombosis, Decompressive Craniectomy