Bupivacaine Liposome Suspension Versus a Concentrated Multi Drug Periarticular Injection

Study Overview
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Brief Summary
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Despite a robust multimodal pain management regimen, patients undergoing total knee arthroplasty (TKA) continue to report low satisfaction with postoperative pain management. Patient satisfaction further declines with any adverse event such as a drug reaction to neuroleptic medications or a patient fall due to a femoral nerve block. A new method of pain management throughout the hospital experience is warranted to improve patient satisfaction and the possibility of related adverse events. The purpose of this study is to examine if there is a difference in post operative pain and morphine (MSO4) total consumption for hospitalized TKA patients without femoral nerve block receiving an intra-operative periarticular injection of bupivacaine liposome suspension versus a concentrated multi drug.

Detailed Description
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The void in the literature is that while multimodal pain management reduces postoperative pain in the majority of TKA patients6-14, too many are still dissatisfied with overall pain control13 and adverse drug reactions (dizziness and somnolence) to neuroleptic medications15. Additionally, postoperative falls are greater with femoral nerve blocks16, and new neurological symptoms are associated with the block17. Bupivacaine liposome suspension periarticular injection has large scale national anecdotal support for TKA pain control with avoidance of regional block adversity. There is one recent randomized control trial in TKA patients favorably comparing periarticular injection with bupivacaine liposome suspension versus bupivacaine hydrochloride (HCL)5. To date the clinical use and published evidence most robustly supports bupivacaine liposome suspension in patients undergoing bunionectomy or hemorrhoidectomy. Additionally, in preparation for shorter hospital stays for total joint arthroplasty, a more effective and better tolerated pain management solution is needed. Hypothesis Statement: Hospitalized TKA patients without a pre-operative femoral nerve block will experience improved postoperative pain control and less MSO4 equivalence consumption when receiving an injection of bupivacaine liposome suspension versus concentrated multi drug.

Official Title
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Bupivacaine Liposome Suspension Versus a Concentrated Multi Drug Periarticular Injection in 70 Patients Undergoing Total Knee Arthroplasty Without Femoral Nerve Block: a Double-blinded, Randomized Clinical Trial

Conditions
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Total Knee Arthroplasty

Intervention / Treatment
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* Drug: bupivacaine liposome suspension
* Drug: concentrated multi drug Ketorlac, Morphine PF, Epinephrine, Ropivicaine, 0.9% NaCL


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: TKA candidacy Osteoarthritis Failure of non-operative treatments to control knee pain Patients able to understand and agree to study inclusion Exclusion Criteria: Subjects have orthopaedic and medical co-morbidities that would thwart postoperative pain control such as extra-articular pathology with referred pain to the knee (spinal stenosis, neuropathy,ipsilateral hip disease) Severe knee deformity Post-traumatic and inflammatory arthritis BMI above 40 Patients unable to receive multimodal pain remitting agents Active knee sepsis Remote sites of active infection Diabetes with A1C > 7 ASA class > lll Cardiac disease failing medical clearance Severe liver disease PAD with AAI < 0.75 Seizure disorder Allergic to any pain remitting agent Alcohol abuse Smoking abuse

Ages Eligible for Study
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Minimum Age: 35 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: bupivacaine liposome suspension<br>bupivacaine liposome suspension periarticular injection | Drug: bupivacaine liposome suspension<br>* bupivacaine liposome suspension periarticular injection<br>* Other names: Exparel;|
| Active Comparator: concentrated multi drug injection<br>concentrated multi drug periarticular injection | Drug: concentrated multi drug Ketorlac, Morphine PF, Epinephrine, Ropivicaine, 0.9% NaCL<br>* Ketorolac 30 mg, Morphine PF 5 mg, Epinephrine 0.6 mg, Ropivacaine 400 mg, QS to 100ml with 0.9% NaCl<br>* Other names: Ketorlac, Morphine PF, Epinephrine, Ropivicaine, 0.9% NaCL;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain Scores (Visual Analog Pain Scores) | visual analog pain scores (scale 0=no pain; 10=worst pain imaginable) | 1 day following surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| MS04 Equivalent Consumption | in hospital total MS04 equivalent consumption | 1 day following surgery |