The Serum Angiotensin Converting Enzyme and Lysozyme Levels in Patients Non-infectious and Infectious Uveitis

Study Overview
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Brief Summary
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This study evaluates the significance of differences in serum angiotensin converting enzyme and lysozyme levels of patients with ocular involvement of other autoimmune inflammatory and infectious diseases.

Detailed Description
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Increased serum levels of angiotensin converting enzyme and lysozyme are considered as inflammatory markers for diagnosis of sarcoidosis which is an autoimmune inflammatory disease. Sarcoidosis, ankylosing spondylitis and Behcet's disease are the most common autoimmune inflammatory diseases involving the eye. Elevated serum angiotensin converting enzyme levels have also been reported in tuberculosis. Syphilis and tuberculosis are the most common infectious diseases involving the eye.

Official Title
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Non-infectious and Infectious Uveitis Diagnosis

Conditions
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Sarcoidosis, Tuberculosis

Intervention / Treatment
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* Other: spectrophotometric assay
* Other: radial immunodiffusion


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Subjects have ocular inflammation diagnosed as sarcoidosis, ankylosing spondylitis, behcet's disease Subjects have ocular infection diagnosed as tuberculosis and syphilis Subjects have refractive errors only Exclusion Criteria: Subjects using ACE inhibitors, systemic steroids, immunosuppressive or immunomodulatory therapies

Ages Eligible for Study
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Minimum Age: 9 Years
Maximum Age: 86 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: serum angiotensin converting enzyme<br>spectrophotometric assay | Other: spectrophotometric assay<br>* measurement of enzyme activity in the serum<br>Other: radial immunodiffusion<br>* measurement of the precipitated ring diameters showing enzyme activity in the serum<br>|
| Active Comparator: serum lysozyme<br>radial immunodiffusion | Other: spectrophotometric assay<br>* measurement of enzyme activity in the serum<br>Other: radial immunodiffusion<br>* measurement of the precipitated ring diameters showing enzyme activity in the serum<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Analysis of serum angiotensin converting enzyme level |  | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Analysis of serum lysozyme level |  | 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Angiotensin converting enzyme, Lysozyme, Ankylosing spondylitis, Behcet's disease, Sarcoidosis, Syphilis, Tuberculosis, Ocular inflammation