Health and Aging Brain Study: Health Disparities Tau Positron Emission Tomography (PET) Scan Study

Study Overview
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Brief Summary
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The purpose of this project is to study the aging brain among participants enrolled in the Health and Aging Brain Study: Health Disparities project . There are a number of things that can influence how people think as they age, including diabetes, depression, as well as our biology. In this study, the investigators seek to study the aging brain by using brain PET scans that create detailed pictures of the brain.

Detailed Description
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There are a number of things that can influence how we think as people age, including diabetes, depression, as well as our biology. In this study, the investigators are using PET scans with a tracer to create detailed pictures of the brain. This information will be used to help the investigators understand how the brain ages and in the future could be used to develop better diagnostics and treatments for Alzheimer's disease and memory loss in Mexican Americans, African Americans, and non-Hispanic whites. The goal of this study is to address this disparity by enrolling ethnically diverse participants in this study.

Official Title
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Health and Aging Brain Study: Health Disparities Tau PET Scan Study

Conditions
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Alzheimer Disease

Intervention / Treatment
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* Diagnostic Test: PI-2620 tracer for Tau PET scan


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Enrolled in the Health and Aging Brain Study HD: Health Disparities project Provided consent to re-contact Willing and capable of undergoing PET scan of the head Exclusion Criteria: Inability to provide informed consent by self or by proxy. Pregnant or breast feeding women* History of alcoholism or drug dependency/abuse within the last 2 years before screening Hypersensitivity to the active substance or to any of the following excipients is contraindicated: sodium dihydrogen phosphate, phosphoric acid, sodium ascorbate, ethanol (anhydrous), water for injection Participants may not be in this study if they do not meet the safety criteria to undergo imaging procedures.

Ages Eligible for Study
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Minimum Age: 50 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Health and Aging Brain Study Cohort<br>Health and Aging Brain Study participants age 50 and older. | Diagnostic Test: PI-2620 tracer for Tau PET scan<br>* Tau PET scans are obtained using PI-2620 tracer provided by Life Medical Imaging.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Health Disparities in Aging | Examine the prevalence of Tau burden among a multi ethnic cohort | Through study completion in 2 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Alzheimer's Disease, Tau PET Scan, Health Disparities, Brain Aging