linjc16/ctgov huggingface dataset:
Continuous Glucose Monitoring and Inflammation in Nondiabetic and Diabetic Patients Undergone Hemodialysis

Study Overview
=================
Brief Summary
-----------------
Evaluation of different glycemic variations between the dialysis period and non-dialysis period in two groups: nondiabetic and diabetic patients undergone two different hemodialysis methods. Thirty-six patients, males and females, aged 50-80 years, with end stage renal disease (ESRD) will undergo hemodialysis and continuous glucose monitoring (CGM). The investigators will evaluate also inflammation markers before and after the different hemodialysis methods.

Conditions
-----------------
Diabetes, End Stage Renal Disease

Intervention / Treatment
-----------------
* Device: Continuous Glucose Monitoring (CGM)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients with or without diabetes mellitus ESRD undergone hemodialysis males and females aged 50-80 Exclusion Criteria: tumors chronic inflammation diseases AMI acute pulmonary diseases

Ages Eligible for Study
-----------------
Minimum Age: 50 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| nondiabetic patients<br>nondiabetic patients with ESRD undergone hemodialysis | Device: Continuous Glucose Monitoring (CGM)<br>* CGM allocated one time for 3 days<br>|
| diabetic patients<br>diabetic patients with ESRD undergone hemodialysis | Device: Continuous Glucose Monitoring (CGM)<br>* CGM allocated one time for 3 days<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| -Hemodialysis tolerability -Hypoglycemia numbers -Hyperglycemia numbers -Inflammation markers |  | before and after each procedure | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| variations of glycemia during the night; insulin-sensitivity |  | at the beginning of the first hemodialysis and at the end of the second hemodialysis | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Diabetes mellitus, ESRD, CGM, Inflammation markers, Hemodialysis, Diabetic patients, Nondiabetic patients, All with ESRD, All undergone hemodialysis
Early Detection of Cardiac Damage by Two-Dimensional Speckle Tracking Echocardiography After Thoracic Radiation Therapy

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to detecte and predict early subclinical cardiac damage induced by thoracic radiation therapy based on two-dimensional speckle tracking echocardiography combined with multiple circulating biomarkers.

Detailed Description
-----------------
This is a monocentric prospective cohort study in which 100 patients treated for malignant tumors and with cardiac radiation exposure will be included.All patient will be followed for 12 months after radiotherapy. Echocardiography, 2D STE parameters and circulating biomarkers will be collected.

Official Title
-----------------
Early Detection of Cardiac Damage by Two-Dimensional Speckle Tracking Echocardiography After Thoracic Radiation Therapy

Conditions
-----------------
Radiation Therapy

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: with malignant tumors will receive radiotherapy with cardiac exposure during the radiotherapy process could receive regular follow-up for 12 months written informed consent Exclusion Criteria: satisfactory echocardiographic images could not be obtained moderate or severe valvular disease cardiomyopathy congenital heart disease refractory hypertension coronary artery disease* heart failure arrhythmia requiring intervention pericarditis acute myocarditis participating in other clinical studies of drug intervention severe liver and kidney dysfunction autoimmune disease pulmonary hypertension coronary artery disease: at least 50% stenosis besed on previous coronary angiography or CTA, or with a history of percutaneous coronary stent implantation. *: with LVEF<50%, unstable angina，or acute myocardial infarction within 3 months.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Early Detection of Cardiac Damage by Two-Dimensional Speckle Tracking Echocardiography After Thoracic Radiation Therapy | To detecte early subclinical cardiac damage induced by thoracic radiation therapy, based on two-dimensional speckle tracking echocardiography combined with multiple circulating biomarkers | 2020-2021 |
Study of Antenatal Care Intervention Directed to Pregnant Women With Obesity

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine whether a behavioural intervention focusing on diet and physical activity is cost-effective in decreasing weight gain during pregnancy among pregnant women with body mass index above 30, and has effect on the weight of offspring at birth and at 2.5 years of age

Detailed Description
-----------------
Obesity in relation to pregnancy is becoming an increasing public health issue and 48% of women assigned to antenatal care in Sweden have overweight (BMI≥25) or obesity (BMI≥30). Obesity is associated with adverse perinatal outcomes, the risks increase with increasing BMI and excessive gestational weight gain (GWG) further increases the risks of adverse pregnancy outcomes. Lifestyle intervention can help pregnant women with obesity to limit their GWG. This study evaluated whether a low-budget antenatal lifestyle intervention programme, with emphasis on nutrition and physical activity, influenced GWG and maternal and perinatal outcomes for pregnant women with obesity. The study also evaluated which specific components of the intervention that had effect.

Official Title
-----------------
Mighty Mums - a Lifestyle Intervention at Primary Care Level for Pregnant Women With Obesity

Conditions
-----------------
Obesity Complicating Childbirth

Intervention / Treatment
-----------------
* Behavioral: Lifestyle intervention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: pregnant BMI>30 Exclusion Criteria: first antenatal care visit after week 20 of the pregnancy abortion miscarriage
Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Open intervention study with 2 control arms
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Intervention<br>Lifestyle intervention | Behavioral: Lifestyle intervention<br> <br> |
| Experimental: Internal controls<br> | Behavioral: Lifestyle intervention<br> <br> |
| Experimental: External controls<br> | Behavioral: Lifestyle intervention<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Gestational weight gain < 7 kg | Weight gain measured from enrollment/first antenatal care visit to last visit before partum, measured in kg | 7 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
obesity, pregnancy, lifestyle, gestational weight gain, weight of offspring, antenatal care, health behavior, physical activity, diet, programme evaluation, costs and costs analysis
Multi-dimensional Signatures for Precisely Predicting the Response and Prognosis of Lung Cancer Patients

Study Overview
=================
Brief Summary
-----------------
This study aims to determine the clinical effectiveness of multi-dimensional signatures in predicting response and prognosis of lung cancer patients. The study is a multi-center perspective research of treatment planning for patients with lung cancer. To characterize clinical effectiveness, the progression-free survival (PFS) and overall survival (OS) impacts of multi-dimensional signatures will be estimated.

Detailed Description
-----------------
Multi-dimensional signatures, including NGS-based genotyping, and other essential detections such as immunohistochemistry (IHC), provides an opportunity to improve outcomes for patients by tailoring treatments to each individual's genomic profile. This is a multi-center single arm research study integrating multi-dimensional signatures into clinical decision-making for patients with lung cancer. The clinical effectiveness of multi-dimensional signatures is unknown in the real-world of clinics. To identify a counterfactual for Pred-lung approach, matching methods combined with administrative healthcare data will be used. The survival impacts of Pred-lung approach compared to usual care in matched controls will then be estimated.

Official Title
-----------------
Multi-dimensional Signatures for Precisely Predicting the Response and Prognosis of Lung Cancer Patients

Conditions
-----------------
Prognosis, Response

Intervention / Treatment
-----------------
* Other: real world treatment by doctors


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with locally-advanced or metastasis lung cancer Life expectancy > 3 months Exclusion Criteria: Age at diagnosis <18 refuse to enroll

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: real world treatment by doctors|real world treatment by doctors|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| PFS | Progression-free survival | through study completion, an average of 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| OS | Overall survival | through study completion, an average of 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Multi-dimensional Signatures, NGS, Lung Cancer
Minimal Invasive Treatment of Achilles Tendinopathy: Focus on Percutaneous Release (Maffulli)

Study Overview
=================
Brief Summary
-----------------
To evaluate the outcome of percutaneous paratenon release for chronic midportion Achilles tendinopathy.

Detailed Description
-----------------
Since 2011 the percutaneous procedure took the place of the open release of the paratenon for the surgical treatment for chronic midportion Achilles tendinopathy in the investigators' center. In this study the investigators re-evaluate the patients undergoing percutaneous surgery since then in order to compare the outcome with the excellent results cited in literature. The patients will be contacted and asked to participate completing a VAS-score, a VISA-A score and agreeing with a clinical examination. Approving by the Ethical Committee of UZLeuven is pending.

Official Title
-----------------
Minimal Invasive Treatment of Achilles Tendinopathy: Focus on Percutaneous Release (Maffulli)

Conditions
-----------------
Tendinopathy

Intervention / Treatment
-----------------
* Procedure: percutaneous paratenon release


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients that underwent percutaneous paratenon release for chronic midportion Achilles tendinopathy Exclusion Criteria: insertional tendinopathy open intervention (partial) Achilles tendon rupture
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| postoperative cases<br>patients that underwent percutaneous release of the paratenon for chronic midportion Achilles tendinopathy | Procedure: percutaneous paratenon release<br>* percutaneous paratenon release for chronic midportion Achilles tendinopathy<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| VISA-A-score | specific questionnaire about (mal-)function of Achilles tendon | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| SF-36-score | questionnaire about well-being | 3 months | 
| VAS-score | questionnaire about pain | 3 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
chronic midportion Achilles tendinopathy, percutaneous paratenon release
Patient Outcome After Cardiac Double Valve Replacement at University Hospital Basel/ Switzerland

Study Overview
=================
Brief Summary
-----------------
To compare patient outcome data after cardiac double valve replacement (aortic and mitral valve) with patient outcome data after aortic valve replacement and mitral valve reconstruction

Detailed Description
-----------------
To compare patient outcome data ( death, re-surgery, change in transvalvular gradient) after cardiac double valve replacement (aortic and mitral valve) with patient outcome data after aortic valve replacement and mitral valve reconstruction in patients with cardiac surgery at University Hospital Basel/ Switzerland since 2009.

Official Title
-----------------
Patient Outcome After Cardiac Double Valve Replacement at University Hospital Basel/ Switzerland

Conditions
-----------------
Cardiac Double Valve Replacement

Intervention / Treatment
-----------------
* Procedure: cardiac valve surgery


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients undergoing cardiac double valve surgery (aortic valve replacement, mitral valve replacement, mitral valve reconstruction) at University Hospital Basel/ Switzerland, starting 2009 Exclusion Criteria: denial of consent
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: cardiac valve surgery|cardiac double valve surgery (aortic and mitral valve)|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| death | death after cardiac valve surgery | time from hospitalisation for cardiac valve surgery and following 12 months | 
| re-surgery | re-surgery after cardiac valve surgery | time from hospitalisation for cardiac valve surgery and following 12 months | 
| change in transvalvular gradient | change in transvalvular Gradient after cardiac valve surgery | time from hospitalisation for cardiac valve surgery and following 12 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
aortic valve replacement, mitral valve reconstruction, mitral valve replacement
Effect of Releasing Quadratus Lumborum Muscle on Hip Joint Range of Motion in Asymptomatic Individuals

Study Overview
=================
Brief Summary
-----------------
The purpose of this study are to compare angles of hip joint between before and after releasing quadratus lumborum muscle.

Detailed Description
-----------------
The 1st physical therapist performed the modified Thomas test position. The participant was asked to lie supine over the edge of the couch. The participant hold one knee to the chest tightly while the other knee was bent over the end of the couch. The 2nd physical therapist measured angles of hip and knee using a standard goniometer at baseline. The quadratus lumborum muscle was released. Then the same measurement was repeated.

Official Title
-----------------
Effect of Releasing Quadratus Lumborum Muscle on Angles of Hip Joint in Asymptomatic Individuals

Conditions
-----------------
Muscle

Intervention / Treatment
-----------------
* Other: releasing muscle


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: asymptomatic male and female volunteers age 18-65 years Exclusion Criteria: having musculoskeletal symptoms (e.g. fibromyalgia, pain at any regions, instability of lower extremities caused by ligamentous injury, injury or trauma to lower extremities), endocrine disease, rheumatoid arthritis taking muscle relaxant or pain killer within 1 day prior to data collection having past history of low back and hip surgery pregnancy having menstruation on data collection day having joint deformities (e.g. knock knee, bow leg)

Ages Eligible for Study
-----------------
Minimum Age: 19 Years
Maximum Age: 23 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: releasing muscle<br>The physical therapist placed thumbs on the quadratus lumborum to release muscle. | Other: releasing muscle<br>* At baseline, hip and knee angles were measured. The quadratus lumborum muscle was released. After that, the hip and knee angles were re-measured.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hip abduction angle | Range of motion (ROM) of hip abduction | 5 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hip flexion angle | Range of motion (ROM) of hip flexion | 5 minutes | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
releasing muscle, quadratus lumborum, hip angle
Endoscopic Complications After Gastric Bypass

Study Overview
=================
Brief Summary
-----------------
Endoscopic complications such as gastro-esophageal reflux disease, ulcera, gastritis, bile reflux, anastomotic stricture and so on are described after gastric bypass surgery. The incidence of these complications after RYGB versus MGB/OAGB are getting observed.

Detailed Description
-----------------
All patients who were readmitted to our centre of excellence for obesity and metabolic surgery (October 2014 - March 2018) are observed regarding endoscopic complications in s.a. RYGB and MGB/OAGB.

Official Title
-----------------
Endoscopic Complications After Roux-en Y Gastric Bypass Versus Mini/One Anastomosis Gastric Bypass

Conditions
-----------------
Obesity, Morbid, Bariatric Surgery Candidate

Intervention / Treatment
-----------------
* Procedure: upper endoscopy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: all patients who underwent RYGB or MGB/OAGB as a primary surgery and were readmitted to tho hospital undergoing upper endoscopy are included Exclusion Criteria: -

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Interventional Model Description: All patients who underwent RYGB and MGB/OAGB readmitted for complications in our centre of excellence are getting observed
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: group 1: RYGB<br>All patients who underwent RYGB and were readmitted to upper endoscopy are getting observed | Procedure: upper endoscopy<br>* endoscopy of the gastrointestinal tract<br>|
| Other: group 2:MGB/OAGB<br>All patients who underwent MGB/OAGB and were readmitted to upper endoscopy are getting observed | Procedure: upper endoscopy<br>* endoscopy of the gastrointestinal tract<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Complication | Pathological finding during upper endoscopy | Up to 15 years post surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Weight Loss since Surgery | Weight Loss since Surgery: Total Weight Loss in % | Up to 15 years post surgery | 
| toxic status | toxic status (NSAID) | Up to 15 years post surgery | 
| toxic status II | toxic status (nicotin) | Up to 15 years post surgery | 
| Revisional Surgery | Revisional Surgery due to complication | Up to 15 years post surgery |