OKS for the Treatment of Hemispatial Neglect

Study Overview
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Brief Summary
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Hemispatial neglect is a disorder where the patient has difficulty attending to objects and information in the left side of space, which occurs following strokes to the right side of the brain. This project is designed to help us understand how optokinetic stimulation treats the symptoms of hemispatial neglect.

Official Title
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Optokinetic Stimulation for the Treatment of Hemispatial Neglect - Safety and Efficacy Studies

Conditions
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Neglect, Hemispatial, Neglect, Sensory, Neglect, Hemisensory

Intervention / Treatment
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* Device: OKS


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with right hemispheric lesions resulting in hemispatial neglect as confirmed by Behavioral Inattention Test or Center of Cancellation Test Exclusion Criteria: Reduced vision Documented vestibular disorder

Ages Eligible for Study
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Minimum Age: 21 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Optimization of OKS<br>Crossover study examining various OKS protocols on improving symptoms of hemispatial neglect | Device: OKS<br>* Optokinetic stimulation will be displayed on a see-through liquid crystal display lens placed in front of the subjects.<br>|
| Experimental: Safety and efficacy study<br>Randomized study assessing the safety and efficacy of OKS in treating hemispatial neglect | Device: OKS<br>* Optokinetic stimulation will be displayed on a see-through liquid crystal display lens placed in front of the subjects.<br>|
| Experimental: Effect of repetitive stimulation<br>Benefits of daily, repetitive OKS in treating hemispatial neglect | Device: OKS<br>* Optokinetic stimulation will be displayed on a see-through liquid crystal display lens placed in front of the subjects.<br>|
| Experimental: OKS and gait<br>Effect of OKS on gait and balance | Device: OKS<br>* Optokinetic stimulation will be displayed on a see-through liquid crystal display lens placed in front of the subjects.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Hemispatial neglect scores | Performance on Center of Cancellation Test | After 1 hour of OKS | 
| Change in Hemispatial neglect scores | Performance on Behavioral Inattention Test | After 1 hour of OKS | 
| Effect of OKS on vision | visual acuity | After 1 hour of OKS | 
| Effect of OKS on vision | reading speed | After 1 hour of OKS | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in secondary hemispatial neglect scores | Line bisection score | After 1 hour of OKS | 
| Changes in secondary hemispatial neglect scores | grip strength | After 1 hour of OKS | 
| Changes in secondary hemispatial neglect scores | extinction score | After 1 hour of OKS | 
| Effect of OKS on gait | Gait assessment | After 1 hour of OKS | 
| Effect of OKS on gait | Balance assessments | After 1 hour of OKS |