The Combination of Endometrial Injury and Freeze All Strategy in Women With a History of RIF

Study Overview
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Brief Summary
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The investigators checked the hypothesis whether endometrial injury performed during the cycle before a frozen embryo transfer in women with RIF can improve pregnancy rates

Detailed Description
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After a freeze all cycle, participants were divided in two groups: an intervention group (n=30), who underwent endometrial injury before the transfer, and a control group (n=30), who underwent no other intervention. The primary outcome was clinical pregnancy rate, while secondary clinical and laboratory parameters. Baseline and cycle characteristics were also compared between groups.

Official Title
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The Combination of Endometrial Injury and Freeze All Strategy in Women With a History of Repeated Implantation Failure.

Conditions
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Repeated Implantation Failures, Endometrial Injury, Hysteroscopy

Intervention / Treatment
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* Procedure: Endometrial injury


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Women with RIF under 42 years old BMI 20-30 Normal endometrial cavity FSH <15 IU/L Absence of immunological or hematological disorder Exclusion Criteria: women over 42 years old FSH>15 IU/L women with chronic immunological or hematological disorder stage III or IV of endometriosis women with pathology concerning the endometrial cavity women with a medical history of adnexectomy or oophorectomy

Ages Eligible for Study
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Minimum Age: 25 Years
Maximum Age: 42 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Interventional Model Description: Endometrial injury in RIF patients
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Endometrial injury<br>Endometrial injury before the embryo transfer of a frozen cycle | Procedure: Endometrial injury<br>* Endometrial injury was performed hysteroscopically after freeze all cycles and during the cycle before the frozen embryo transfer<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Physiological parameter - Live birth rate | The complete expulsion or extraction from a woman of a product of fertilization, after 22 completed weeks of gestational age | 22 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Physiological parameter -Clinical pregnancy rate | A pregnancy diagnosed by ultrasonographic visualization of one or more gestational sacs or definitive clinical signs of pregnancy | 7 weeks | 
| Adverse event - Miscarriage | Spontaneous loss of a clinical pregnancy before 22 completed weeks of gestational age | 22 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Endometrial injury, Hysteroscopy, RIF, IVF, ART