Effects of Phototherapy by Low-level Light-emitting Diode Therapy (LEDT) on Clinical, Biochemical, Biomechanical, Histologic and Genetic Responses of Muscle Performance of Young Males Submitted to Physical Strength Training

Study Overview
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Brief Summary
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Muscle performance is largely influenced by modulations in gene expressions of muscle tissue. In this context, light-emitting diode therapy (LEDT) has been used to improve muscle performance in experimental models and human researches. Thereby, the investigators examined modulations in gene expression of muscle tissue as well as biochemical, biomechanic and histologic adaptations influenced by exercise associated to LEDT.

Detailed Description
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This study assessed muscle performance in isokinetic dynamometry and led press device, gene expression by RT-PCR, lactate, creatine kinase and morphology of muscle tissue by immunohistochemical analysis

Official Title
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Effects of Phototherapy by Low-level Light-emitting Diode Therapy (LEDT) on Clinical, Biochemical, Biomechanical, Histologic and Genetic Responses of Muscle Performance of Young Males Submitted to Physical Strength Training

Conditions
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Healthy

Intervention / Treatment
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* Device: Effective light-emitting diode therapy
* Device: Placebo light-emitting diode therapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: healthy males aged between 18 and 28 years with a body mass index (BMI) equal to or less than 26 kg/m2, moderated pattern of physical activity Exclusion Criteria: previous injury to the femoral quadriceps or hamstring muscles (within 6 months prior to study), osseous or articular disorder in the lower limbs, cardiovascular system disorders, systemic disease, and taking prescription medicines or using dietary supplements such as muscle mass builders.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 28 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Effective light-emitting diode therapy and training<br>Effects of effective light-emitting diode therapy therapy on muscle performance of young males submitted to physical strength training | Device: Effective light-emitting diode therapy<br> <br> * Other names: Light-emitting diode therapy;|
| Placebo Comparator: Placebo light-emitting diode therapy and training<br>Effects of placebo light-emitting diode therapy on muscle performance of young males submitted to physical strength training | Device: Placebo light-emitting diode therapy<br> <br> * Other names: Light-emitting diode therapy;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Modulations on muscle gene expression by RT-PCR |  | 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Muscle performance in leg press device |  | 12 weeks | 
| Muscle performance in leg extension device |  | 12 weeks | 
| Muscle performance in isokinetic dynamometer |  | 12 weeks | 
| Gene expression | Gene expression of muscle tissue by RT-PCR | 12 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Light-emitting diode therapy, Muscle performance, Gene expression, Functional performance