Total-body 13N-NH3 PET/CT to Study the Blood Perfusion in Whole Body

Study Overview
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Brief Summary
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The aim of our study is to analyze and quantitate whole-body blood perfusion by total-body 13N-NH3 PET/CT(uEXPLORER), and evaluate the influence to other organs caused by the decreased cardiac function.

Detailed Description
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Participants are invited to participate in a research that seeks to understand the dynamic blood perfusion in human body. The investigators expect to have sixteen participants in this study at Renji Hospital, Shanghai. About thirteen of the participants will be patients who have been diagnosed with decreased cardiac function, three participants will be healthy individuals with no known vascular disease. These healthy subjects will allow researchers to compare blood perfusion difference with those of persons with decreased cardiac function. All the participants will undergo the same procedure. If participants agree to participate in this study, researchers will first interview participants and review the past medical record in order to document the medical history. When the screening procedures confirm that participants are eligible to participate in the study, participants will receive one dose of the non-therapeutic administration of a radioactive tracer called N-13 ammonia(13NH3) , then undergo one total body 13NH3 PET/CT Scan (uEXPLORER) to determine the blood flow value of the brain, kidney and other organs. The total body 13NH3 PET/CT Scan will allow investigators to observe and analyze the real-time blood flow differences between patients with between healthy controls and decreased cardiac function.

Official Title
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The Application of Total-body 13N-NH3 PET/CT to Study the Blood Perfusion System in the Whole Body

Conditions
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Cardiac Output

Intervention / Treatment
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* Device: total-body PET/CT(uEXPLORER , United Imaging Healthcare, China)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Three healthy volunteers with normal EF values Patients with decreased cardiac function, while their heart function grading above II(New York Heart Association,NYHA) Aged 18 75 years old Written informed consents will be offered and signed by all participants Exclusion Criteria: History of vascular-related diseases in other organs Severe liver and kidney dysfunctions Patients who are pregnant or breast feeding People under the age of 18 years old Heart function grading below II(NYHA) inability to lie or to maintain posture in the scanner for one hour

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Healthy controls<br>All healthy subjects will undergo the following intervention: 13N-NH3 PET/CT scan on the total-body uEXPLORER scanner. | Device: total-body PET/CT(uEXPLORER , United Imaging Healthcare, China)<br>* This prospective study will enroll sixteen patients, including three healthy volunteers, thirteen patients with decreased cardiac function . All of them will have a whole-body PET/CT(uEXPLORER , United Imaging Healthcare, China) in our department, Renji Hospital.<br>|
| Patients with decreased cardiac function<br>All patients will undergo the following intervention: 13N-NH3 PET/CT scan on the total-body uEXPLORER scanner. | Device: total-body PET/CT(uEXPLORER , United Imaging Healthcare, China)<br>* This prospective study will enroll sixteen patients, including three healthy volunteers, thirteen patients with decreased cardiac function . All of them will have a whole-body PET/CT(uEXPLORER , United Imaging Healthcare, China) in our department, Renji Hospital.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluation of Multi-Organ Blood Perfusion by Total Body Dynamic uEXPLORER PET/CT Scan | The total-body 13N-NH3 PET/CT will be adopted to evaluate the blood flow differences in whole body between healthy controls and patients with decreased cardiac function. | 4 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Total-body; PET/CT; N-13 ammonia; Blood perfusion