linjc16/ctgov huggingface dataset:
Iron Status and Lung Function in Pediatric Asthma

Study Overview
=================
Brief Summary
-----------------
Iron has a variable role regarding asthma and respiratory function. In addition, iron deficiency may affect spirometry results in asthmatic children. So, we aimed to assess the effect of ion status on lung function in childhood asthma

Detailed Description
-----------------
This cross-sectional study included fifty asthmatic children in the age group of 6-16 years. Asthmatic patients were classified according to their complete blood count and iron profile into 2 groups: group 1; asthmatic children without iron deficiency anemia (IDA), group 2; asthmatic children with IDA. All patients underwent full history taking, clinical examination, laboratory investigations, asthma control test, and pulmonary function tests. Pulmonary function testing was performed using standardized spirometry. Lung function was measured by forced expiratory volume in one second (FEV1), forced vital capacity (FVC), FEV1/FVC, and maximal mid-expiratory flow (MMEF 25-75%) of FVC. both patients' groups are compared.

Official Title
-----------------
Iron Status and Its Relation to Lung Function in Pediatric Asthmatics

Conditions
-----------------
Pulmonary Function Tests

Intervention / Treatment
-----------------
* Diagnostic Test: iron studies


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Confirmed diagnosis of bronchial asthma: The diagnosis of bronchial asthma in the studied children was based on clinical examination The diagnosis of iron deficiency anemia was supported by criteria provided and updated by the World Health Organization Exclusion Criteria: chronic lung diseases other than asthma Severe systemic illnesses such as liver, renal diseases, and nutritional disorders

Ages Eligible for Study
-----------------
Minimum Age: 6 Years
Maximum Age: 16 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: iron studies|Pulmonary function testing was performed using standardized spirometry for asthmatic patients with iron deficiency anemia and those without iron deficiency anemia|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| improved asthma control | higher asthma control test | 2 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
asthma, pediatric, iron deficiency anemia
A Survey of Psychological Status of Medical Workers and Residents in the Context of 2019 Novel Coronavirus Pneumonia

Study Overview
=================
Brief Summary
-----------------
Due to the outbreak of 2019 Novel Coronavirus Pneumonia in Wuhan, Hubei province, medical staff and residents are facing great psychological pressure, the investigator plan to use electronic questionnaire to carry out investigation research.

Detailed Description
-----------------
From December 2019, 12 cases of new coronavirus pneumonia broke out in Wuhan, and then the epidemic spread rapidly. Till February 1, 2020, there were 14446 confirmed cases in China, 19544 suspected cases, and 304 deaths. There were confirmed cases reported in 34 provincial administrative regions in China; 23 foreign countries reported new coronavirus pneumonia cases, 147 confirmed cases. In the face of the rapid spread of the epidemic, people's panic and anxiety have seriously affected the prevention and control of the epidemic. In the face of the occupational exposure risk and treatment brought by the sudden outbreak of the epidemic, the change of mental state of medical staff may affect the prevention and control of the epidemic. In order to help the epidemic prevention and control, the investigator plan to carry out investigation research.

Official Title
-----------------
A Survey of Psychological Status of Medical Workers and Residents in the Context of 2019 Novel Coronavirus Pneumonia in Wuhan, China

Conditions
-----------------
Virus; Pneumonia

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: can use mobil phone or computer volunteer to take part in the investigation Exclusion Criteria: can not use phone or computer unwilling to take part in the investigation
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| residents<br>Voluntary residents Can use mobile phone or computer | |
| medical staff<br>Voluntary residents Can use mobile phone or computer | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| GHQ-12(general health questionnaire-12) | GHQ-12(general health questionnaire-12): minimal score 0, maximal score 12, higher scores mean a better or worse outcome. | 2 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| IES-R(Impact of Event Scale-Revised) | IES-R(Impact of Event Scale-Revised):score range:0-88, the higher the worse | 2 weeks |
Measuring Depth of Unconsciousness at the End of Life Using Bispectral Index (BIS)

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to use the BIS monitor to assess the degree of consciousness in pre-terminal palliative patients admitted to our palliative care unit and to ascertain if this tool provides a more accurate assessment of consciousness in this specific group of patients than clinical observation of consciousness and the use of sedation scales. We hypothesize that the measured BIS results provide a more accurate assessment of the patient's level of consciousness than routine clinical observation or the use of sedation scales.

Official Title
-----------------
Measuring Depth of Unconsciousness at the End of Life: the Reliability of the BIS Monitoring as an Assessment Tool Versus Sedation Scales

Conditions
-----------------
Loss of Consciousness at End of Life

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Pre-terminal palliative patients with a life expectancy of 72 hours or less at the start of the observation. Exclusion Criteria: lack of consent of patient or representative

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measuring the accuracy of BIS monitoring in assessing the evolution of the level of consciousness in pre-terminal patients | Measuring the accuracy of BIS monitoring in assessing the evolution of the level of consciousness in pre-terminal patients with a life expectancy of 72 hours or less from the moment of the first clinical signs of dying and loss of consciousness until the moment of death. | 72 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Determining the evolution of BIS values, measured in pre-terminal patients | Determining the evolution of BIS values, measured in pre-terminal patients with a life expectancy of 72 hours or less from the moment of the first clinical signs of dying and loss of consciousness until the moment of death. | 72 hours |
Evaluate the Efficacy and Safety of LMT1-48 on Reducing Body Fat in Overweight Subject

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate the safety and efficacy of LMT1-48(Probiotics) compared to a placebo in reducing the body fat in overweight subjects

Official Title
-----------------
a Randomised, Double Blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of LMT1-48 on Reducing Body Fat in Overweight Subject

Conditions
-----------------
Overweight

Intervention / Treatment
-----------------
* Dietary Supplement: LMT1-48
* Dietary Supplement: Placebo


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age between 19 and 70 years Overweight (25 kg/m2 ≤ body mass index (BMI) < 30 kg/m2) Exclusion Criteria: Pregnancy or breast-feeding Unstable body weight (body weight change > 10% within 3 months before screening)

Ages Eligible for Study
-----------------
Minimum Age: 19 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Probiotics<br> | Dietary Supplement: LMT1-48<br>* capsules containing Probiotics<br>|
| Placebo Comparator: Placebo<br> | Dietary Supplement: Placebo<br>* capsules that did not contain any probiotics<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change from baseline fat percentage at 12 week | the body composition of the subjects was measured via dual-energy X-ray absorptiometry (DEXA) to determine | at baseline and 12-week follow-up |
Effect of Caudal Nalbuphine on Postoperative Emergence Agitation in Pediatrics Undergoing Infra-umbilical Surgeries

Study Overview
=================
Brief Summary
-----------------
Effect of caudal nalbuphine on postoperative emergence agitation in pediatrics undergoing infra-umbilical surgeries and pain assessment

Official Title
-----------------
Effect of Caudal Nalbuphine on Postoperative Emergence Agitation in Pediatrics Undergoing Infra-umbilical Surgeries

Conditions
-----------------
Post Operative Pain, Agitation, Emergence

Intervention / Treatment
-----------------
* Drug: Nalbuphine
* Drug: Bupivacain


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age 2_12 years Both genders ASA I_II Children undergoing infra-umbilical surgeries Exclusion Criteria: Guardians refusal congenital anomalies at the lower spine or meringues Increased intracranial pressure Skin infection at site of injection Bleeding diathesis Known allergy to any drugs used

Ages Eligible for Study
-----------------
Minimum Age: 2 Years
Maximum Age: 12 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Nalbuphine<br> | Drug: Nalbuphine<br>* Caudal nalbuphine injection in pediatrics undergoing infra-umbilical surgeries<br>Drug: Bupivacain<br>* Caudal bupivacaine in pediatrics undergoing infra-umbilical surgeries<br>|
| Active Comparator: Bupivacaine<br> | Drug: Bupivacain<br>* Caudal bupivacaine in pediatrics undergoing infra-umbilical surgeries<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Effect of caudal nalbuphine on postoperative emergence agitation according to Pediatric Anasthesia emergence delirium (PAED) | PAED ( The pediatric anesthesia emergence delirium scale) | Up to 2 hours postoperative | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative pain assessment according to Modified Children's Hospital of Eastern Ontario Pain Scale (modified CHEOPS) |  | For 24 hours postoperative |
Miglustat on Gaucher Disease Type IIIB

Study Overview
=================
Brief Summary
-----------------
evaluate the combination therapy with Miglustat and enzyme replacement therapy (ERT) on Gaucher disease

Detailed Description
-----------------
understand if Miglustat (glucosylceramide synthase inhibitor) could improve neuropathy in patients with Gaucher disease

Official Title
-----------------
Evaluation of Combination Therapy With Miglustat and Enzyme Replacement Therapy on Gaucher Disease Type IIIB

Conditions
-----------------
Gaucher Disease

Intervention / Treatment
-----------------
* Drug: Miglustat
* Drug: ERT


Participation Criteria
=================
Eligibility Criteria
-----------------
Case_Miglustat Inclusion Criteria: Confirmed diagnosis of Gaucher Disease: blood test shown lack of beta- glucocerebrosidase, and found L444P homozygous on GBA gene. Aged 6 years old or above. Already have regular ERT (30-120 IU/kg/ every 2 weeks) at least a year; dosage and frequency of ERT had not been changed in recent 3 months. Exclusion Criteria: History of tremor and abnormal extremities perception ( pain, numbness, tingle etc.) Abnormal kidney function. Pregnant or plan to have a baby ( potentially pregnant patient need to be transferred to gynecologist for the test and promise to have proper contraception measures). Allergic to Miglustat. Control_normal Inclusion Criteria Age 6-18 years No significant physical, mental, or psychiatric problems Exclusion criteria 1. Children with eye disease (not include myopia, hyperopia, Astigmatism)

Ages Eligible for Study
-----------------
Minimum Age: 6 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Case_Miglustat<br>Besides regular ERT, patients in this group also need to take Miglustat for 24 months. | Drug: Miglustat<br>* combine miglustat and ERT to see if neurologic manifestations can be improved<br>* Other names: Zavesca;Drug: ERT<br>* enzyme replacement therapy<br>|
| No Intervention: Control<br>Patients will be tested for their pupil cycle time. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Improve in Purdue Pegboard test speed |  | 24 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Enzyme Replacement Therapy, Miglustat, Gaucher Disease
Effects of Massage Therapy and Facial PNF in Early Bell's Palsy

Study Overview
=================
Brief Summary
-----------------
Effects of Massage therapy and Facial PNF in early Bell's palsy

Detailed Description
-----------------
It is an interventional study in which investigator will give massage therapy to one group of patients and facial PNF techniques to other group to evaluate the efficacy of these intervention on bell's palsy pateints

Official Title
-----------------
Effects of Massage Therapy and Facial PNF in Early Bell's Palsy

Conditions
-----------------
Bell Palsy

Intervention / Treatment
-----------------
* Other: Facial PNF technique
* Other: Massage therapy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Both males and females with age between 20 to 50 years All patients diagnosed with Bell's palsy Non traumatic onset Acute onset 1 to 3 weeks Either right or left side Exclusion Criteria: Subject who have other Neurological disorder Subjects who have impaired cognition Complete paralysis of face Open wound on face

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Randomized control trail
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: control group<br>massage therapy will be given to this group of participants | Other: Massage therapy<br>* frictional massage to stimulate the weak muscle groups<br>* Other names: Passive massage;|
| Experimental: experimental group<br>Facial PNFtechnique will be given to this group of participants | Other: Facial PNF technique<br>* Stimulation techniques used to facilitate the weak muscle groups<br>* Other names: Proprioceptive Neuromuscular Facilitation;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sunnybrook facial grading scale | complete tool for assessing facial movement outcomes. Lower score (Zero) means complete paralysis and higher (100) means normal | assessment will be done after 6 weeks | 
| Facial Clinimetric Evaluation Scale | to evaluate the impairment and disability associated with facial weakness. It is calculated ranging from 0 (worst) to 100 (best) | assessment will be done after 6 weeks |
Ectopic Lipid Deposition and Insulin Resistance in After Treatment of Acromegaly

Study Overview
=================
Brief Summary
-----------------
This study investigates fat distribution in people with acromegaly. The investigator is also investigating the change of fat distribution before and after treatment of acromegaly. The investigator will compare the results of people with acromegaly to the results of healthy volunteers.

Official Title
-----------------
Ectopic Lipid Deposition and Insulin Resistance in After Treatment of Acromegaly

Conditions
-----------------
Acromegaly

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Ages 18 - 75 yr (both groups) Study subjects with active acromegaly Healthy controls Exclusion Criteria: Serum creatinine or alanine aminotransferase (ALT) > 2 times the upper limit of normal, metastatic cancer. Controls will be receiving no medications and have no chronic diseases, including cancer, hypertension or diabetes mellitus. Contraindications to MRI imaging (both groups) like those with certain metal implants, surgical clips or pacemakers. Pregnant women

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Acromegaly<br>All study subjects with acromegaly will be studied twice - once during the active stage of their disease (pre-treatment) and a second time: 3 months after treatment of acromegaly. Controls will be studied at one time point. | |
| Healthy controls<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Liver Fat | Change in intrahepatic fat after biochemical control of acromegaly | Baseline and 3-month follow-up visit | 
| Change in Thigh Muscle Cross-sectional Area | Change in thigh muscle cross-sectional area after biochemical control of acromegaly | Baseline and 3-month follow-up visit |
MDA D-Dimer / Recurrent DVT Study

Study Overview
=================
Brief Summary
-----------------
To determine whether treatment and further investigation can be safely withheld in patients who present with suspected recurrent deep vein thrombosis (DVT) and have either a (i) negative D-Dimer or (ii) a positive D-Dimer with normal serial compression ultrasound.

Official Title
-----------------
A Cohort Study Evaluating the Safety of a Diagnostic Strategy Involving D-Dimer and Compression Ultrasonography in Patients With Suspected Recurrent Deep Vein Thrombosis

Conditions
-----------------
Deep Vein Thrombosis

Intervention / Treatment
-----------------
* Procedure: various diagnostic measures for DVT (e.g., CUS)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age 18 or older Currently suspected for recurrent DVT Has a prior history of objectively documented DVT or PE Exclusion Criteria: Comorbid condition limiting survival to less than 3 months History of hypersensitivity to contrast medium Renal dysfunction with a creatinine of > 150 mcmol/L Treatment with full-dose therapeutic unfractionated or low molecular weight heparin that was initiated 24 hours or more prior to eligibility assessment Pregnancy or lactation Symptomatic for pulmonary embolism Absence of symptoms within five days prior to presentation Participation in another trial precluding the use of the diagnostic algorithm in this study Geographically inaccessible for follow-up Compression ultrasound, venogram, IPG, or D-dimer performed PRIOR to assessment

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: various diagnostic measures for DVT (e.g., CUS)|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Suspected DVT during follow-up |  |  | 
| Suspected PE during follow-up |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
deep vein thrombosis, DVT
Effects of Open-label vs Double-blind Treatment in IBS

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to investigate placebo effects and peppermint oil in Irritable Bowel Syndrome.

Official Title
-----------------
Effects of Open-label vs Double-blind Treatment in IBS.

Conditions
-----------------
Irritable Bowel Syndrome, Placebo Effect, Placebos, Peppermint Oil

Intervention / Treatment
-----------------
* Drug: placebo
* Dietary Supplement: peppermint oil


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Meet Rome IV diagnostic criteria for IBS

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: open-label placebo<br> | Drug: placebo<br> <br> |
| Experimental: double-blind placebo<br> | Drug: placebo<br> <br> |
| Experimental: double-blind peppermint oil<br> | Dietary Supplement: peppermint oil<br> <br> |
| No Intervention: no additional treatment<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Irritable Bowel Syndrome - Symptom Severity Score (IBS-SSS) From Baseline to Six Weeks. | Score ranges from 0-500, 0 indicates no symptoms, 500 indicates worst possible symptoms | 6 weeks |