Correlation of Serum Adropin to Testosterone and Adiponectin in Obese Men

Study Overview
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Brief Summary
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Obesity is associated with low testosterone in men and with dyslipidemia. Adropin hormone is negatively correlated with body mass index and is associated with dyslipidemia. correlation between adropin and testosterone will be evaluated.

Detailed Description
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Obesity, a worldwide epidemic is associated with multiple adverse health outcome as diabetes mellitus, hypertension and cardiovascular diseases caused mainly by dyslipidemia linked to obesity. Low testosterone levels in obese men were found associated with dyslipidemia. Adropin is a new metabolic hormone that was first isolated in liver and brain tissues, It was observed that mice fed on a high-fat diet (HFD) had a rapid increase in adropin expression compared to control values. In human also, adropin levels were negatively correlated with body mass index (BMI) and were associated with dyslipidemia. Adiponectin is a protein that is mainly produced by white adipose tissue and has an important role in lipid metabolism. Serum adiponectin concentrations were decreased in obese compared to normal weight men and significantly correlated with testosterone level.

Official Title
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Correlation of Serum Adropin to Testosterone and Adiponectin in Obese Men

Conditions
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Obesity, Dyslipidemias

Intervention / Treatment
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* Diagnostic Test: lipid profile: Total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL) and high density lipoprotein (HDL))
* Diagnostic Test: Total testosterone
* Diagnostic Test: Adropin
* Diagnostic Test: Adiponectin


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age from 18 years to 50 years. Clinically free except from obesity Exclusion Criteria: Diabetes mellitus Hypertension Heart failure Kidney disease Smoking

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| obese men<br>Adult obese men (BMI ≥ 30 kg/m2) | Diagnostic Test: lipid profile: Total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL) and high density lipoprotein (HDL))<br>* blood samples will be collected after 10 hours fasting<br>Diagnostic Test: Total testosterone<br>* blood samples will be collected after 10 hours fasting<br>Diagnostic Test: Adropin<br>* blood samples will be collected after 10 hours fasting<br>Diagnostic Test: Adiponectin<br>* blood samples will be collected after 10 hours fasting<br>|
| normal men<br>normal weight men (18.5 ≤ BMI < 25 kg/m2 ) | Diagnostic Test: lipid profile: Total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL) and high density lipoprotein (HDL))<br>* blood samples will be collected after 10 hours fasting<br>Diagnostic Test: Total testosterone<br>* blood samples will be collected after 10 hours fasting<br>Diagnostic Test: Adropin<br>* blood samples will be collected after 10 hours fasting<br>Diagnostic Test: Adiponectin<br>* blood samples will be collected after 10 hours fasting<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| changes in lipid profile (TC, TG, LDL, HDL) levels | expected higher TC, TG, LDl levels and lower HDL levels in obese men compared to normal | 6 months | 
| changes in total testosterone levels | expected lower testosterone levels in obese men compared to normal men | 6 months | 
| changes in adropin level | expected lower adropin levels in obese men compared to normal men | 6 months | 
| changed in adiponectin levels | expected lower adiponectin level in obese men compared to normal men | 6 months | 
| correlation between adropin and testosterone |  | 6 months | 
| correlation between adropin and adiponectin |  | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Adropin, adiponectin, testosterone, obese men