Determination of Predictive Value of Echography Doppler Abnormalities

Study Overview
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Brief Summary
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In order to avoid to use a traumatic and iatrogenic examen (phlebography), the purpose of the study is to validate echography doppler in the diagnosis of asymptomatic related catheter related thrombosis.

Detailed Description
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Phlebography is the gold standard for the diagnosis of asymptomatic catheter related thrombosis but can not be performed in about 15% of patients because of arm swelling and lack of superficial veins. Echography doppler is an easy, cheap and atraumatic way to make the diagnosis of deep vein thrombosis. The value of echography doppler has been proven for the diagnosis of symptomatic deep venous thrombosis of lower and upper limbs and for the diagnosis of proximal asymptomatic lower limbs. To validate the echography doppler we intend to correlate asymptomatic findings to the occurrence symptomatic related catheter related thrombosis. Patients with localized breast cancer treated with chemotherapy will be enrolled in the study. An echography doppler will be performed on day 8, 30 and 90 after catheter insertion. Findings in asymptomatic patients (thrombus visualisation, lack of vein compressibility, variation of physiologic vein blood flow) will thereafter be correlated with the presence or absence of clinical signs of catheter related thrombosis. In order to assess if they are risk factors for catheter related thrombosis, we will determine the level D-Dimer, microparticles and the results of generation thrombin tests before and 2 days after catheter insertion.

Official Title
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CAVECCAS Value of Risk Factors for Symptomatic Catheter Related Thrombosis in Patients With Breast Cancer Treated With Adjuvant Chemotherapy

Conditions
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Breast Cancer, Upper Extremity Deep Vein Thrombosis, Secondary

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: women over 18 histologically proven breast cancer localized breast cancer without metastasis adjuvant or neo adjuvant chemotherapy insertion of central catheter with port for chemotherapy central catheter for more than three months inform consent follow up for three months Exclusion Criteria: ongoing anticoagulant therapy previous central catheter femoral catheter double lumen catheter central catheter without port platelets < 80G/L, TQ < 50%, fibrinogen < 1 g/L creatinin > 175mole/L

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Symptomatic catheter related thrombosis, as confirmed by echography doppler, phlebography or angiography scan |  | within 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Breast cancer, Catheter related thrombosis, Diagnosis, Echography doppler, Risk factors