Exercise Training and Inflammatory Mediators in COPD

Study Overview
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Brief Summary
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Chronic obstructive pulmonary disease (COPD) is widely spread all over the world. It is predicted to be the third leading cause of death by 2020[1]. COPD is a common, preventable treatable disease that is characterized by an airflow limitation which is not fully reversable[2].

Detailed Description
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Chronic obstructive pulmonary disease (COPD) is widely spread all over the world. It is predicted to be the third leading cause of death by 2020. COPD is a common, preventable treatable disease that is characterized by an airflow limitation which is not fully reversable.Not only the long-term exposition to noxious particles and gases contributes to the development of COPD, but also so many others factors such as genetics and cigarette smoking. It has been shown that cigarettes are harmful and contributed to different extra pulmonary disorders. Indeed, it induced a systemic inflammation that was considered as a key process in the pathogenesis of COPD and triggered the activation of inflammatory cells and an abnormal increase of circulating cytokines such as CRP, interleukin (IL6), IL8, tumor necrosis factor alpha (TNF alpha) and leptin.

Official Title
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Effect of Exercise Training on Inflammatory Mediators in COPD

Conditions
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COPD

Intervention / Treatment
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* Other: Endurance Training ET
* Other: Resistance Training RT


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: COPD diagnosed by pulmonary function testing Clinically stable Abscence of other obstructive diseases Signed written consent Exclusion Criteria: Neuromuscular diseases -Severe psychiatric, neurologic or musculoskeletal conditions and /or instable--- -- cardiovascular diseases. Contre-indications to physical therapy Acute exacerbations a month before the intervention

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: ET<br>Active Comparator: ET Endurance training were prformed. Intensity was gradually increased. | Other: Endurance Training ET<br>* Endurance training were prformed. Intensity was gradually increased.<br>|
| Other: RT<br>Resistance training were prformed. Intensity was gradually increased. | Other: Resistance Training RT<br>* Resistance training were prformed. Intensity was gradually increased.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Enzyme linked immunosorbent assay for serum cytokines levels change | The interleukines were determined by ELISA assays with commercial kits | Baseline, 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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COPD, Inflammation, exercise training