Effect of Dual Task on Upper and Lower Extremity Skills in Parkinson's Disease

Study Overview
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Brief Summary
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The aim of the study is to investigate the change of lower and upper extremity skills with dual task in Parkinson's disease patients and to determine the differences between Parkinson's disease patients with different stages of disease and the healthy controls regarding the change of lower and upper extremity skills with dual task.

Official Title
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Examining The Change of Upper and Lower Extremity Skills With The Effect of Dual Task in Parkinson's Disease Patients

Conditions
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Parkinson Disease, Movement Disorders

Intervention / Treatment
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* Other: Timed Up and Go Test
* Other: 10 Meter Walk Test
* Other: Purdue Pegboard Test


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Modified Hoehn & Yahr (H&Y) stages 1 to 3 at least 40 years of age 21 or more MoCA score. Exclusion Criteria: other neurologic disorder any orthopedic problem that could prevent to participate in the study severe dyskinesia or tremor visual or speech problems

Ages Eligible for Study
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Minimum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Mild Stage Parkinson's Disease Patients<br>Modified Hoehn and Yahr stage 1-2 | Other: Timed Up and Go Test<br>* It requires individual to stand up from an armed chair, walk 3m, turn around, walk back to the armed chair, and sit down again<br>Other: 10 Meter Walk Test<br>* 10 Meter Walk Test measures the time required to complete straight walk of 10 meters distance<br>Other: Purdue Pegboard Test<br>* Purdue Pegboard test evaluates the fine manuel dexterity<br>|
| Moderate Stage Parkinson's Disease Patients<br>Modified Hoehn and Yahr stage 2.5-3 | Other: Timed Up and Go Test<br>* It requires individual to stand up from an armed chair, walk 3m, turn around, walk back to the armed chair, and sit down again<br>Other: 10 Meter Walk Test<br>* 10 Meter Walk Test measures the time required to complete straight walk of 10 meters distance<br>Other: Purdue Pegboard Test<br>* Purdue Pegboard test evaluates the fine manuel dexterity<br>|
| Healthy Control<br>Healthy People | Other: Timed Up and Go Test<br>* It requires individual to stand up from an armed chair, walk 3m, turn around, walk back to the armed chair, and sit down again<br>Other: 10 Meter Walk Test<br>* 10 Meter Walk Test measures the time required to complete straight walk of 10 meters distance<br>Other: Purdue Pegboard Test<br>* Purdue Pegboard test evaluates the fine manuel dexterity<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Timed Up and Go Test | Functional mobility is assessed by using the timed up and go test. The timed up and go test measures the time that a patient needs to stand up from a chair, walk a 3-m distance, come back and sit back on the chair. | 10-15 seconds | 
| 10 Meter Walk Test | 10 Meter Walk Test measures the time required to complete straight walk of 10 meters distance. | 10-15 seconds | 
| Purdue Pegboard Test | Purdue Pegboard Test assesses the speed and motor dexterity of each hand and the manual dexterity using both hands at the same time. The PPT consists of a board with two columns with 25 holes each and a specific number of pins, washers and collars placed in four containers across the top of the board. | 3-5 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Modified Hoehn and Yahr Scale | Modified Hoehn and Yahr Scale allocates stages from 0 to 5 to indicate the relative level of disability and stage of disease. Higher level indicates worse physical condition. | 1 minute | 
| Montreal Cognitive Assessment (MoCA) | Montreal Cognitive Assessment (MoCA) will be used in order to evaluate cognition. It assesses different cognitive domains: attention and concentration, executive functions, memory, language, visuoconstructional skills, conceptual thinking, calculations, and orientation.It' score ranged from 0 to 30 and higher points indicates better cognitive outcomes. | 10-15 minutes | 
| Short-Form 8-Item Parkinson's Disease Questionnaire (PDQ-8) | The short-form 8-item Parkinson's disease Questionnaire (PDQ-8) is the most commonly used scale measuring health related quality of life (HRQoL) in PD patients. It includes 8 items, and each item has five options (never, occasionally, sometimes, often, always or cannot do at all). The total score ranges from 0 to 32. Higher scores indicates poorer quality of life. | 1-2 minutes |