linjc16/ctgov huggingface dataset:
Influence of Depressive Mood on Rehab Outcome

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine the effects of depressive mood on outcomes of an in-house rehabilitation program.

Official Title
-----------------
Influence of Depressive Mood on Short Term Rehab Outcome at an Acute Geriatrics Unit

Conditions
-----------------
Depressive Mood

Intervention / Treatment
-----------------
* Other: exercise


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 2-week in-house-rehab at an acute geriatric unit ability to take part in assessments understanding German language Informed Consent Exclusion Criteria: anti-depressive medication shorter than 4 weeks before enrollment In-house rehab < 14 days advanced stage of dementia

Ages Eligible for Study
-----------------
Minimum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Depressive Group<br>GDS 15 (Geriatric Depression Score) ≥5 at baseline | Other: exercise<br> <br> |
| Active Comparator: Non-depressive Group<br>GDS 15 (Geriatric Depression Score) <5 Points at baseline | Other: exercise<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Physical Performance Test |  | Change from baseline at day 14 +/-1 | 
| de Morton Mobility Index | The de Morton Mobility index is a method for measuring changes in mobility and enhancing the continuity of patient care across clinical settings | Change from baseline at day 14 +/-1 | 
| Performance Orientated Mobility Assessment (POMA) | Task-oriented outcome measure that assesses gait and balance ability | Change from baseline at day 14 +/-1 | 
| Barthel Index | The Barthel index is an ordinal scale used to measure performance in activities of daily living | Change from baseline at day 14 +/-1 | 
| Function Index Physiotherapy |  | Change from baseline at day 14 +/-1 | 
| Function Index Occupational Therapy |  | Change from baseline at day 14 +/-1 | 
| Grip strength measurement | measured with JAMAR dynamometer | Change from baseline at day 14 +/-1 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Charlson Comorbidity Index | Measure of comorbidity and multimorbidity | Day 1+/-1 | 
| Timed Test of Money Counting |  | Day 1+/-1 | 
| Geriatric Depression Scale (GDS-15) |  | Day 1+/-1 and day 14+/-1 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
rehabilitation, exercise, outcome measurement
Bivalirudin PCI Registry in Heparin Induced Thrombocytopenia/Heparin Induced Thrombocytopenia and Thrombosis Syndrome (HIT/HITTS) Patients

Study Overview
=================
Brief Summary
-----------------
To monitor the frequency of the development of thrombocytopenia in patients with Heparin Induced Thrombocytopenia/Heparin Induced Thrombocytopenia and Thrombosis Syndrome receiving bivalirudin during Percutaneous Coronary Intervention

Official Title
-----------------
Bivalirudin PCI Registry in HIT/HITTS Patients

Conditions
-----------------
Heparin-Induced Thrombocytopenia, Heparin-induced Thrombocytopenia and Thrombosis Syndrome

Intervention / Treatment
-----------------
* Drug: bivalirudin


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Clinically Documented History of HIT/HITTS Suspicion of HIT/HITTS Exclusion Criteria: Bleeding Diathesis Ischemic Stroke Chronic Thrombocytopenia Hematologic Malignancy Contraindication to bivalirudin Pregnant or nursing mothers

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>Patients with HIT/HITTS who require anticoagulation for PCI | Drug: bivalirudin<br>* Bivalirudin; 0.75mg/kg/h IV bolus followed immediately by 1.75 mg/kg/h infusion for the duration of the procedure<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Platelet counts |  | 6, 12, 24, 48 Hours | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
HIT, HITTS
Study of Cellular Impairments Involved in Diabetic Complications

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to examine if an early detectable dysfunction in a cellular component (mitochondria) may predict complications in diabetes mellitus.

Official Title
-----------------
Study of the Significance of Mitochondrial Dysfunction for Development of Diabetic Complications

Conditions
-----------------
Diabetes Mellitus

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diabetes mellitus Exclusion Criteria: Age below 18 yrs Psychiatric disease Other metabolic disease

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| diabetes no complications<br> | |
| diabetes with complications<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| endothelial damage |  | 3 times pr years |
Predictors of Patient Attitudes and Barriers to Skin Cancer Screening

Study Overview
=================
Brief Summary
-----------------
This is a cross-sectional survey distributed to a convenience sample of patients in a waiting room of an academic dermatology clinic. The survey assesses patient experiences with full body skin exams and attitudes towards full body skin exams. The survey is designed to help investigators better understand how many patients are not getting full body skin exams, why this may be occurring, and what types of interventions may be enacted to increase the number of patients getting full body skin exams.

Official Title
-----------------
Predictors of Patient Attitudes and Barriers to Skin Cancer Screening

Conditions
-----------------
Skin Cancer

Intervention / Treatment
-----------------
* Other: Survey


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 18 years old or older English-speaking Exclusion Criteria: previously completed the survey

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients who responded to the survey<br> | Other: Survey<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patients reporting ever having had a full body skin examination |  | 2 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Number of patients, full body skin exam, Survey, preferences
the Health Crisis at the Healthcare Professionals, Careers and Non-careers, a Month After the Containment Period

Study Overview
=================
Brief Summary
-----------------
The investigator wish to study, at a distance from the lifting of confinement (1 month), whether the psychological impact on professionals in nursing and non-nursing care establishments is associated with their living context (professional and personal situation) during confinement.

Detailed Description
-----------------
The context of confinement and of the global pandemic is a major source of stress for the entire population: separation of loved ones, loss of freedom, uncertainty about the infectious status, boredom. All of these factors can cause negative mental health consequences. Having little social contact was one of the factors increasing the negative psychological impact of confinement. People suffering from psychological disorders are particularly vulnerable during quarantine periods. On March 17, 2020, the French government implemented national containment measures due to the Covid-19 epidemic. Although the effects of containment have been studied for fragile populations, no study to date has focused on the specific population of healthcare facility staff. These caregivers have for the most part continued their professional activity, but they have been confronted with the fear of contracting or causing patients to contract Covid-19. At a distance from the lifting of confinement (1 month), the investigator wish to study whether the highlighting of anxiety or depression in these healthcare professionals is associated with their context of life (professional and personal situation) during confinement

Official Title
-----------------
Demonstration of the Level of Anxiety / Depression of Healthcare Professionals and Non-healthcare Professionals One Month After the Confinement Period

Conditions
-----------------
Psychology, Social

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Nursing and non-nursing care professionals Exclusion Criteria: Refusal to participate Subject included in an interventional study
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Demonstration of the level of anxiety / depression of healthcare professionals and non-healthcare professionals one month after the confinement period | Anxiety-depression will be assessed by the hospital anxiety and depression scalequestionnaire. The context of life during confinement will be assessed by a self-questionnaire collecting data relating to lifestyle and work. | 1 month |
AMG 701 Expanded Access Program

Study Overview
=================
Brief Summary
-----------------
Expanded access requests for AMG 701 may be considered for adult patients with relapsed and/or refractory multiple myeloma whose disease is in partial response or better after AMG 420 therapy. To request access, use Responsible Party contact information provided in this record.

Intervention / Treatment
-----------------
* Drug: AMG 701


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: - Exclusion Criteria: -

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: AMG 701|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Assessment of Nutritional Status and Role of Insulin-like Growth Factor-1 in Children

Study Overview
=================
Brief Summary
-----------------
Many studies done on children with thalassemia have shown a variable prevalence of defective IGF-I concentrations have been shown to be low in the majority of children, with or without GH deficiency. The Aim of this study to assess nutritional status and role of Insulin-like growth factor 1 (IGF-1) and its associating factors in children with thalassemia major

Official Title
-----------------
Assessment of Nutritional Status and Role of Insulin-like Growth Factor-1 in Children With Thalassemia Major

Conditions
-----------------
Thalassemia

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Children in the age group of 2-18 years with confirmed diagnosis of Beta thalassemia major. Exclusion Criteria: Children with other chronic diseases (cardiac, renal, vascular) Children with malignancy

Ages Eligible for Study
-----------------
Minimum Age: 1 Year
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients<br>67 children in the age group of 2-18 years with confirmed diagnosis of Beta thalassemia major. | |
| Healthy control<br>35 healthy children | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| IGF-1 | insulin-like growth factor-1 which measured by enzyme linked immunosorbent assay (ELISA). | at the time of recruitment | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Insulin-like growth factor 1
Effects of Ward Cats in Patients With Substance Abuse, Depression and Psychosis at UPK Basel

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to explore the relationship between ward cats and patient satisfaction and stations atmosphere in patients with substance abuse, depression and psychosis. Moreover, we wanted to investigate the patients perception of the ward cats and the relationship between station atmosphere perceived by the employees working wards with and without cat at UKP Basel.

Detailed Description
-----------------
The following tools were used to address these aims: Available MüPF data regarding patient satisfaction of 170 inpatients during 2016 was analyzed. Available MüPF data regarding patient satisfaction of 151 inpatients during 2017 was analyzed. 33 patients were interviewed regarding their perception of the cats 30 staff members at the wards filled in questionnaires regarding station atmosphere (EssenCES)

Official Title
-----------------
Effects of the Presence of Ward Cats on Patient Satisfaction and Ward Atmosphere for Patients With Substance Abuse, Depression and Psychosis at UPK Basel

Conditions
-----------------
Satisfaction, Station Atmosphere

Intervention / Treatment
-----------------
* Other: cat


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Inpatient of the 7 wards at UPK Basel diagnosed with substance abuse, depression and psychosis staff working at these wards Exclusion Criteria: none

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| ward cat<br>Patients and staff at wards that have a cat present | Other: cat<br>* Cat living at the ward<br>|
| no ward cat<br>Patients and staff at wards that have no cat present | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patient satisfaction (MüPF) | Questionnaire MüPF 27 | August - Sept 2017 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| station atmosphere | Questionnaire EssenCES filled out by staff members | August - Sept 2017 | 
| Patient satisfaction (interview) | Patients ratings of satisfaction is assessed in a semi-structured interview | August - Sept 2017 | 
| Patients perception of cats | Patients perception of cats is assessed in a semi-structured interview | August - Sept 2017 |
Effect of Vaginal Electrical Stimulation on Female Sexual Dysfunction

Study Overview
=================
Brief Summary
-----------------
vaginal electrical stimulation improves female sexual dysfunction

Conditions
-----------------
Female Sexual Dysfunction

Intervention / Treatment
-----------------
* Device: Vaginal Electrical Stimulation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: women with complaint of sexual dysfunction at any part of sexual cycle Exclusion Criteria: pregnancy previous gynecologic surgery pelvic organ prolapsus greater than stage 1 women with neurological disease and anatomical defect women with anatomical defect

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Vaginal Electrical Stimulation<br>A vaginal probe inserted, and a medium frequency (50 Hz) alternating current was administered for 5 seconds on, 5 seconds off the intensity of the current was started at 0 mA, and gradually increased until pelvic muscle contractions was observed, then increased according to patient tolerance. Each patient received a 20 minute session once a week for total 8 sessions | Device: Vaginal Electrical Stimulation<br>* A vaginal probe inserted, and a medium frequency (50 Hz) alternating current was administered for 5 seconds on, 5 seconds off. the intensity of the current was started at 0 mA, and gradually increased until pelvic muscle contractions was observed, then increased according to patient tolerance. each patient received a 20 minute session once a week for total 8 session<br>* Other names: MyoBravo Electrical Stimulation Device;|
| Placebo Comparator: plasebo<br>sham electrical stimulation | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from baseline in on domains and total score of Female Sexual Function Index (FSFI) at week 8 |  | Baseline, Week 8 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from baseline in power, endurance, dynamic endurance and fast contractions on the PERFECT scheme at week 8 |  | Baseline, Week 8 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Vaginal Electrical Stimulation
Breathing With a Facemask Exercise Performance

Study Overview
=================
Brief Summary
-----------------
This study will determine the dyspnea response in chronic lung disease volunteers during treadmill walking with and without added inspiratory resistance. This study will also determine the level of dyspnea and exercise sense of effort in individuals walking on a treadmill when elevations occur. Comparisons will be made of a participant's exercise response with and without increased inspiratory resistance. In this study, exercise performance will be analyzed based on physiological and perceptual measures. The participant will undergo two sessions: one session will be a standard exercise walking test without an inspiratory resistance; the other session will be the same standard exercise walking test while breathing with an inspiratory resistance equal to a N95 facemask (R=10-15 cmH2O/L/sec). Performance will be determined by physiological measures. Perception will be determined by scores based on numerical scales and automatically with the forehead Vitality remote monitoring sensor.

Official Title
-----------------
Measuring Exercise Performance and Perception With Facemask Resistance

Conditions
-----------------
Pulmonary Disease, Chronic Obstructive

Intervention / Treatment
-----------------
* Combination Product: CereVu Objective Dyspnea Score


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Former pulmonary rehabilitation patients that are now participating in maintenance exercise classes Males and females with an age range of 18 years or older Subjects must be able to walk on treadmill for multiple sessions Exclusion Criteria: The subjects in each experiment will be recruited for a distribution of gender, ethnicity and age

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Pulmonary Rehab Patients<br>Patients who attend respiratory therapy at John Muir Pulmonary Rehab facility | Combination Product: CereVu Objective Dyspnea Score<br>* Small forehead wearable and mobile app<br>|
| Control<br>Healthy adults, 18+ | Combination Product: CereVu Objective Dyspnea Score<br>* Small forehead wearable and mobile app<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between dyspnea as measured by the device and reported dyspnea by subjects |  | 2 hours |