Effect of Butyrogenic Fibers in IBS Patients

Study Overview
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Brief Summary
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Despite there being no clearcut advantages, one of the most common recommendations in IBS management is to increase the amount of dietary fibres. In some IBS patients fibres have a deleterious effect on pain and bloating. It has been shown that butyrate can increase colonic sensitivity in rats. Our purpose is to study whether butyrogenic fibres can modify rectal sensitivity and symptoms in IBS and healthy control through a modification of colonic flora.

Detailed Description
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Despite there being no clearcut advantages, one of the most common recommendations in IBS management is to increase the amount of dietary fibres. In some IBS patients fibres have a deleterious effect on pain and bloating. It has been shown that butyrate can increase colonic sensitivity in rats. Our purpose is to study whether butyrogenic fibres can modify rectal sensitivity and symptoms in IBS and healthy control through a modification of colonic flora.

Official Title
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Effect of an Enriched Butyrogenic Fibres Diet on Rectal Sensitivity in Healthy Control and IBS Patients.

Conditions
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Irritable Bowel Syndrome

Intervention / Treatment
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* Drug: Diet


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Female aged 18-60 years Normal volunteers and patients with IBS assessed by Rome II criteria Effective contraception Affiliated to National Health Service Having received oral and written information about the study Having provided her written informed consent Exclusion Criteria: Significant clinical or biological abnormality Organic gastrointestinal disease Subjects having lower than 15g/day or higher than 20g/day fibres intake Antibiotic treatment during the month preceding the pre inclusion day Antispasmodics, antidiarrheics, laxatives, and prokinetics during the week preceding the pre inclusion day and during all the study period. Digestive surgery tract except appendectomy and cholecystectomy Alcohol abuse Drug addiction Major psychiatric disorder

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Diet|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Discomfort threshold to rectal distension |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rectal sensitivity : first sensation and threshold for first sensation of the need to defecate. |  |  | 
| Intestinal discomfort (questionnaire) |  |  | 
| Quality of life (questionnaire) |  |  | 
| Taxonomic composition of colonic flora |  |  | 
| Functional composition of colonic flora |  |  | 
| Fermentation profile of ingested fibre |  |  | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Diet, Fiber, Irritable Bowel Syndrome, Colonic Flora