Automated 3D (SonoAVC) Versus 2D Ovarian Follicles Assessment in IVF Cycles: a Randomized Controlled Trial

Study Overview
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Brief Summary
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Accurate assessment of the size of follicles is important in IVF treatment.Timing of oocyte maturation and subsequent egg collection is largely based on follicle size. An accurate assessment of follicle size and appropriate timing of HCG result in retrieval of more mature oocytes, improved fertilization and higher pregnancy rates. in 3D technology- fter the capturing of a 3D image of an ovary, SonoAVC automatically analyzes the volume dataset, identifies the boundaries of hypoechoic follicles, and provides estimates of their absolute dimensions. These measurements include the largest diameters in three orthogonal planes, the mean follicular diameter (MFD), the volume of the follicle, and the volume-based diameter (d(V)) of the follicle. In the current study the investigators aim to evaluate the use of this automated technique of follicle measurement vs. standard 2D technology on the timing of oocyte maturation and subsequent oocyte retrieval. The investigators speculate that 3D assessment will increase the rate of mature oocyte collection, and eventually will improve other treatment outcomes such as fertilization rate.

Detailed Description
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Not desired

Official Title
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Automated 3D (SonoAVC) vs 2D Ovarian Follicles Assessment in IVF Cycles: a Randomized Controlled Trial

Conditions
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Infertility

Intervention / Treatment
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* Other: 3D follicles assessment
* Other: 2D follicles assessment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age:18-39, cycle number 1-4 Exclusion Criteria: PCOS Endometriosis Poor ovarian response TESA sperm

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 39 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: 3D follicles assessment<br>During IVF treatment all ultrasound examinations will use 3D- SonoAVC technology. Timing of hCG injection and oocyte collection will be based on follicle volume and 3D-volume based diameter. | Other: 3D follicles assessment<br>* 3D ultrasound evaluation in IVF treatment (vs 2D ultrasound)<br>|
| Active Comparator: 2D follicles assessment<br>During IVF treatment all ultrasound examinations will use standard 2D ultrasound. Timing of hCG injection and oocyte collection will be based on follicle diameter. | Other: 2D follicles assessment<br>* 2D ultrasound in IVF treatment (vs 3D ultrasound)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| percentage of matured oocytes |  | one IVF cycle (within two weeks) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fertilization rate in ICSI |  | one IVF cycle/ patient (within two weeks) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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IVF, 3D ultrasound, SonoAVC, patients in IVF treatment