Sugammadex Provide Better Surgical Condition Compared With Neostigmine in Laryngeal Microsurgery.

Study Overview
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Brief Summary
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This study aims to make a comparison of surgical condition and recovery time between rocuronium 0.45 mg/kg and neostigmine group and rocuronium 0.9 mg/kg and sugammadex group.

Detailed Description
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This study aims to make a comparison of surgical condition and recovery time between moderate neuromuscular bloackade with reversal using neostigmine group and deep neuromuscular bloackade with reversal using sugammadex group.

Official Title
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Comparison Sugammadex With Neostigmine in Laryngeal Microsurgery.

Conditions
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Neuromuscular Blockade

Intervention / Treatment
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* Other: Injection of neostigmine or sugammadex


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: American Society of Anesthesiologist Physical status classification 1 or 2 elective laryngeal microsurgery under general anesthesia Exclusion Criteria: BMI >25 or < 20 kg/m2 Patients taking intercurrent medication Glutamic Oxalacetate Transaminase or Glutamic Pyruvate Transaminase > 40 IU/L, Cr > 1.4 mg/dl

Ages Eligible for Study
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Minimum Age: 19 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: rocuronium 0.45 - neostigmine<br>when anesthetic induction, inrocuronium 0.45 mg/kg will be administered for muscle relaxation. When the end of operation, a injection of neostigmine or sugammadex will be administered. | Other: Injection of neostigmine or sugammadex<br>* At anesthetic induction, rocuronium 0.45 to rocuronium 0.45 - neostigmine group or rocuronium 0.9 mg/kg to rocuronium 0.9 - sugammadex group will be injected for muscle relaxation. During surgical procedure, we will monitor train of four (TOF) using nerve stimulator. After operation, neostigmine 50 mcg/kg or sugammadex 4 mg/kgl be injected.<br>* Other names: neostigmin or sugammadex;|
| Active Comparator: rocuronium 0.9 - sugammadex<br>When anesthetic induction, rocuronium 0.9 mg/kg will be injected to rocuronium 0.9 - sugammadex group for muscle relaxation. When the end of operation,, a injection of neostigmine or sugammadex be administered. | Other: Injection of neostigmine or sugammadex<br>* At anesthetic induction, rocuronium 0.45 to rocuronium 0.45 - neostigmine group or rocuronium 0.9 mg/kg to rocuronium 0.9 - sugammadex group will be injected for muscle relaxation. During surgical procedure, we will monitor train of four (TOF) using nerve stimulator. After operation, neostigmine 50 mcg/kg or sugammadex 4 mg/kgl be injected.<br>* Other names: neostigmin or sugammadex;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Laryngoscopic Score | Definitions for evaluation of Laryngoscopycondition. : Easy = jaw relaxed, no resistance to blade insertion, fair = jaw not fully relaxed, slight resistance to blade insertion, difficult = poor jaw relaxation, active resistance of the patient to laryngoscopy. Variables Excellent Good Poor | At the beginning of surgery, the surgeon rated the laryngoscopy condition | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Recovery Time From Neuromuscular Blockade | We measured recovery time ffrom the injection of neostigmine or sugammadex to TOF ratio 0.9 | from the injection of neostigmine or sugammadex up to 30 minutes |