Rapid Build of HIV Related Protective Barriers

Study Overview
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Brief Summary
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The purpose of the study is to screen the optimal intervention strategies to rapid establish the protective barriers against HIV-infection by maximally decreasing the viremia among HIV- infected patients.

Detailed Description
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Sexual transmission became the primary route of HIV transmission in China and heterosexual transmission also contributed greatly to HIV epidemic which was mostly reported in South-west rural areas. In past years, Yunnan has experienced powerful campaign of scaling-up the HIV identification as well as antrertroviral therapy. This study will investigate how to reach the last two of HIV'90-90-90 targets': to provide antiretroviral therapy (ART) for 90% of who diagnosed HIV infection and to achieve viral suppression for 90% of those treated. The study population consists of participants who received an newly diagnosed HIV infection within the study period. All rerolled participants will be randomized into different study group. In intervention group, medical institutions will provide patients personal involved intervention strategies which guided by frequent viral load detection, and providing of the dosage form of 400 mg EFV in their antiviral therapy. Main assessment measures are viral suppression rate of HIV-infected patients and treatment coverage .

Official Title
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Cohort Study on Appropriate Strategies of The Rapid Build of HIV Related Protective Barriers in Yunnan, China

Conditions
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Viral Suppression of HIV Infection

Intervention / Treatment
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* Behavioral: Personal involved intervention strategies
* Drug: The dosage of 400mg EFV


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: HIV-positive participants who received an newly diagnosed HIV infection within the study period Having a current residential address inside of pilot site limits Eighteen years old or above HIV transmission is heterosexual contact Exclusion Criteria: IDU Having severe mental disorder

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: routine care group<br>Medical institutions will provide patients routine care according to the national program standard. | |
| Experimental: medicine intervention group<br>The dosage of 400 mg EFV will be used in the antiviral therapy. | Drug: The dosage of 400mg EFV<br>* The dosage of 400mg EFV will be used in the antiviral therapy.<br>|
| Experimental: consolidated intervention group<br>Medical institutions will provide personal involved intervention strategies as well as the providing of dosage form of 400 mgEFV in their antiviral therapy. | Behavioral: Personal involved intervention strategies<br>* Medical institutions will provide personal involved intervention strategies for patients which guided by viral load testing monthly until viral load drop below the detection limit.<br>Drug: The dosage of 400mg EFV<br>* The dosage of 400mg EFV will be used in the antiviral therapy.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Viral suppression of HIV-infected patients |  | 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Treatment coverage |  | 12 months |