Urodynamics and Clinical Factors That Are Associated With Bladder Over-sensitivity

Study Overview
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Brief Summary
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Urodynamic examination evaluates storage and empting phases of the urinary bladder. It enables the clinician to correlate physiologic findings to patients' complains. The data gathered during the examination divided to storage and empting. During the storage phase, bladder sensation is measured while the bladder is filled with sterile water. During years of practice, we noticed that early sensation (bladder over-sensitivity) is occasionally associated with bladder outlet obstruction (as demonstrated in the emptying phase of the examination.

Detailed Description
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The study includes patients who were referred to Urodynamics examination due to lower urinary tract symptoms. There is no actual intervention during the examination. Though, patients are asked to fill an International prostate symptom score (IPSS-questionnaires).

Official Title
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Urodynamics and Clinical Factors That Are Associated With Bladder Over-sensitivity

Conditions
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Overactive Bladder Syndrome, Bladder Outlet Obstruction, Benign Prostate Enlargement, Stress Incontinence (Female) (Male), Bladder Disease

Intervention / Treatment
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* Other: IPSS questionnaire


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All patients refered to Asaf HaRofeh Medical Center for Urodynamic examination Exclusion Criteria: Inability to sign an informed concent Administration of analgesics 8 hours prior to the examination Known urethral stricture Chronic bladder or urethral pain Active cystitis Permanent urinary catheter

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients undergoing urodynamic<br>All patients older than 18 who are refered for Urodynamics examination | Other: IPSS questionnaire<br>* IPSS is an 8 question (7 symptom questions + 1 quality of life question) written screening tool used to screen for, rapidly diagnose, track the symptoms of, and suggest management of patients with lower urinary tract symptoms. It was validated for both genders.<br>* Other names: International Prostate Symptoms Score;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Early sensation during the filling phase | Bladder oversensitivity (early sensation), a diagnosis made by symptoms and urodynamic investigations. Defined as an increased perceived bladder sensation during bladder filling with specific cystometric findings of: (i) an early first desire to void; (ii) an early strong desire to void, which occurs at low bladder volume; (iii) a low maximum cystometric bladder capacity; no abnormal increases in detrusor pressure. | During the urodynamic examination | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Urodynamics, Bladder sensation, confounding factors