Alterations in Postprandial Glucose and Lipid Metabolism in Patients With Obstructive Sleep Apnea

Study Overview
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Brief Summary
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The purpose of this study is to examine postprandial glucose and lipid metabolism in patients with obstructive sleep apnea.

Detailed Description
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Obstructive sleep apnea (OSA) is an increasingly prevalent condition that is characterized by repetitive upper airway obstructions. OSA has been independently associated with insulin resistance, suggesting that OSA may contribute to the development of type 2 diabetes and the metabolic syndrome. Recently, postprandial glucose and lipid have been reported as excellent predictors for mortality and cardiovascular risk. However, the association between postprandial glucose, lipid metabolism and OSA are not clear. In addition, humoral factors such as ghrelin and leptin are associated with obesity and OSA, but postprandial changes of which in patients with OSA are not well known. The aim of present study is to examine postprandial glucose and lipid metabolism, humoral factors in OSA before and after 3 months of continuous positive airway pressure (CPAP) treatment.

Official Title
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Examination of Association Between Glucose, Lipid Metabolism and Obstructive Sleep Apnea

Conditions
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Obstructive Sleep Apnea

Intervention / Treatment
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* Device: CPAP treatment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Subjects on admission for sleep study under the Respiratory Care and Sleep Control Medicine, Kyoto University Hospital. Subjects diagnosed with OSA (apnea hypopnea index >=5/hour) by overnight polysomnography. Exclusion Criteria: Subjects treating for acute infections or malignancy. Subjects with severe anemia, diabetes,and renal failure.

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: CPAP<br> | Device: CPAP treatment<br>* maintains upper airway patency and minimizes the obstructive events<br>* Other names: REMstar (Respironics), Auto Set(Resmed), Goodnight (Tyco Healthcare);|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| postprandial metabolic markers including glucose, cholesterol, triglyceride, ghrelin, leptin |  | baseline and 3 months after CPAP | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| respiratory events (ie. apnea-hypopnea index) |  | baseline and 3 months after CPAP | 
| inflammatory biomarkers (ie. IL-6, CRP) |  | baseline and 3 months after CPAP | 
| quality of life |  | baseline and 3 months after CPAP | 
| sleep quality |  | baseline and 3 months after CPAP | 
| sympathetic activity in urine |  | baseline and 3 months after CPAP | 
| appetite |  | baseline and 3 months after CPAP | 
| endothelial function |  | baseline and 3months after CPAP | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Postprandial glucose, lipid metabolism, humoral factors