Efficacy of Twice Weekly Hemodialysis in Patients With Residual Kidney Function

Study Overview
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Brief Summary
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The study will determine the efficacy of twice weekly hemodialysis in patients with residual kidney function.

Detailed Description
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Hemodialysis patients who have residual kidney function will undergo two 4-week study (twice weekly versus thrice weekly hemodialysis). Blood, urine, and dialysate samples will be collected at the end of each study period to determine adequacy of treatment and to assess uremic solute levels. Participants will complete quality of life questionnaires and cognitive paper tests. Food records and medications may be monitored.

Official Title
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Efficacy of Twice Weekly Hemodialysis in Patients With Residual Kidney Function

Conditions
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Hemodialysis, Kidney Failure, Chronic

Intervention / Treatment
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* Other: Twice weekly hemodialysis
* Other: Thrice weekly hemodialysis


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Stable dialysis patients able to provide consent Exclusion Criteria: Use of antibiotics for last two months or expected antibiotic use Recent hospitalization or other event resulting in instability of food intake Residual kidney function < 2.5 mL/min

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Twice weekly hemodialysis<br>Participants will undergo hemodialysis twice per week. | Other: Twice weekly hemodialysis<br>* Effect of hemodialysis prescriptions of twice weekly versus thrice weekly on quality of life will be evaluated. All hemodialysis will be prescribed to achieve adequate treatment based on current National Kidney Foundation guidelines.<br>|
| Other: Thrice weekly hemodialysis<br>Participants will undergo hemodialysis three times per week. | Other: Thrice weekly hemodialysis<br>* Effect of hemodialysis prescriptions of twice weekly versus thrice weekly on quality of life will be evaluated. All hemodialysis will be prescribed to achieve adequate treatment based on current National Kidney Foundation guidelines.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| QOL: KDQOL36 | Kidney Disease Quality of Life: Health-related quality of life. Physical component and Mental Components are measured on a scale of 0 to 100, with higher scores being better. | 4 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Solute Concentration | mg/dl | 4 weeks | 
| Symptom | Dialysis Symptom Index: measures symptom burden on a scale of 0 to 150, with higher scores being worse. | 4 weeks | 
| Cognition | Trail B Making Test | 4 weeks | 
| Cognition | Digit Substitution Test | 4 weeks |