linjc16/ctgov huggingface dataset:
Safety and Efficacy Study of Transplantation of EPCs to Treat Idiopathic Pulmonary Arterial Hypertension

Study Overview
=================
Brief Summary
-----------------
Experimental data suggest that transplantation of endothelial progenitor cells (EPCs) attenuates monocrotaline-induced pulmonary hypertension in rats and dogs. In addition, clinical studies suggest that autogolous progenitor cells transplantation is feasible and safe in patients with ischemic disease. This study will investigate the feasibility, safety, and initial clinical outcome of intravenous infusion of autologous EPCs in patients with idiopathic pulmonary arterial hypertension.

Conditions
-----------------
Idiopathic Pulmonary Arterial Hypertension

Intervention / Treatment
-----------------
* Procedure: Transplantation of autologous endothelial progenitor cells


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Clinical diagnosis of idiopathic pulmonary arterial hypertension in New York Heart Association (NYHA) functional class II to III a mean pulmonary artery pressure more than 30 mmHg on right heart catheterization the ability to walk ≥50 m during a standardized 6-minute walk test Exclusion Criteria: Pulmonary hypertension as a result of heart disease, pulmonary disease, sleep-associated disorders, chronic thromboembolic disease, autoimmune or collagen vascular disease, HIV infection, liver disease, NYHA functional class IV, major bleeding requiring blood transfusion, diabetes, renal dysfunction, and evidence for malignant diseases were excluded

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Transplantation of autologous endothelial progenitor cells|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Study the Safety and Efficacy of Probiotics Use in Premature Infants

Study Overview
=================
Brief Summary
-----------------
Prophylactic enteral probiotics may enhance clinical markers and biomarkers of preterm infants' health, and may also play a role in reducing NEC and associated morbidity.

Official Title
-----------------
Study the Safety and Efficacy of Probiotics Use in Premature Infants

Conditions
-----------------
Infant, Premature, Diseases

Intervention / Treatment
-----------------
* Dietary Supplement: breast milk with Bifidobacterium Longum subp. Infantis R0033
* Dietary Supplement: breast milk


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: born with weight<1500 g hospitalized within 48 hours after birth Exclusion Criteria: present with evidence or suspicion of congenital intestinal obstruction perforation gastroschisis large omphalocele congenital diaphragmatic hernia major congenital heart defects

Ages Eligible for Study
-----------------
Maximum Age: 2 Days

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Intervention Model: Parallel Assignment


Arms and Interventions

| Intervention/Treatment |
| --- |
|Dietary Supplement: breast milk with Bifidobacterium Longum subp. Infantis R0033|nan|
|Dietary Supplement: breast milk|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Calprotectin will be used to determine the effect for probiotics |  | day1 and day30 of the observation |
Wrist-based Blood Pressure Monitoring Study

Study Overview
=================
Brief Summary
-----------------
To observe blood pressure variation in various real-world settings

Detailed Description
-----------------
This is an observational study, which will utilize a wrist-based blood pressure monitor to explore blood pressure variation in up to 75 participants in various real-world settings. There is no intervention in this study. The study will take place over a 4-week period. During this time, participants will be asked to sample their blood pressures 1) at random times, several times per day; 2) during specific periods of either emotional stress or relaxation; 3) during guided orthostatic testing. Study participants will utilize an application on their smartphones to log the device-measured blood pressures and flag selected blood pressure measurements as either being part of the orthostatic testing or during periods of emotional stress/relaxation. At the close of the study a post-study questionnaire will be sent electronically to each participant.

Official Title
-----------------
A Pilot Study to Explore the Feasibility and Operational Pathways of Incorporating a Wrist-based Blood Pressure Monitoring Device Into the All of Us Research Program

Conditions
-----------------
Blood Pressure

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Consortium members within the All of Us Research Program ≥18 years of age Own an iOS or Android device Exclusion Criteria: Inability to give informed consent <18 years of age Inability to understand written English language

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| All of Us Research Program (AoURP) consortium members<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood pressure measurements | The primary endpoint for this study is assessing variability in blood pressure measurements (both systolic and diastolic). Blood pressure measurements will be sought over the course of 4 weeks during the following activities: During waking hours (several times a day for at least 2 days out of the week) Orthostatic maneuvers (seated and then 1 minute after standing up) At times of stress and relaxation. | 4 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
blood pressure, mobile device
Impact of the COVID-19 Pandemic on the Quality of Psychological Life (COVID-PRO-IMPACT)

Study Overview
=================
Brief Summary
-----------------
The COVID-19 pandemic is profoundly changing the way people live and work. After the health impact, it is the mental and psychological impact that reaches varying degrees in the entire world population. The previous Asian epidemics have had a lasting impact on the health professionals concerned. In France, no study has yet assessed the psychological impact of this health crisis on the level of health professionals. Investigators propose to study prospectively the evolution of the state of stress and anxiety of all the professionals practicing within the gynecology-obstetrics departments of 18 French hospitals. Investigators also hypothesize that the mental repercussions in terms of stress and anxiety within the same service could be different depending on the professional status and the place of exercise (the French regions being impacted in different ways). In addition to the epidemiological interest, the results of this study may help us to target regions and professionals who will need psychological support during and after this serious health crisis.

Official Title
-----------------
Impact of the COVID-19 Pandemic on the Quality of Psychological Life of Healthcare Professionals

Conditions
-----------------
Covid 19, Stress, Psychological

Intervention / Treatment
-----------------
* Other: Questionnaires on psychological quality of life


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: person over 18 person exercising a profession in the health field person having expressed his non-opposition Exclusion Criteria: inability to understand the information given and the questionnaire person deprived of liberty, person under guardianship.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Questionnaires on psychological quality of life|Assessement of evolution of the psychological quality of life of health professionals during the confinement period linked to the COVID-19 pandemic by two questionnaires (one during the confinement period and the second one month after the end of the confinement period)|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Stress state score, during the confinement period | Stress state score, during the confinement period, established by a comparison VAS (visual analogue scale) compared to a period outside COVID-19 (from -5: considerable degradation to +5: considerable improvement, with 0: no change) | About 10 minutes ( Questionnaire filling time) |
Effect of Fentanyl With Topical Levobupivacaine With Nasal Packing in Endoscopic Nasal Surgery

Study Overview
=================
Brief Summary
-----------------
the Investigators aim to study the effect of fentanyl with topical levobupivacaine with nasal packing in endoscopic nasal surgery

Official Title
-----------------
Effect of Fentanyl With Topical Levobupivacaine With Nasal Packing in Endoscopic Nasal Surgery

Conditions
-----------------
Analgesia During Removal of Nasal Pack After Nasal Surgery

Intervention / Treatment
-----------------
* Drug: Fentanyl + Topical Levobupivacaine
* Drug: levobupivacaine


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria:1. All patients in the age of 18-60 year 2. ASA I-II 3. Undergoing elective nasal endoscopic surgery - Exclusion Criteria: Patients will also be excluded if any perioperative cardiovascular or respiratory event occurred which the anaesthetist with clinical responsibility for the patient thought would make the study intervention clinically unacceptable. unsatisfactory preoperative peripheral arterial oxygen saturation. Unsatisfactory preoperative hemoglobin level. Neurological or psychiatric disease.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: saline<br>saline for pain for nasal packing | |
| Active Comparator: levobupivacaine<br>levobupivacaine for pain of nasal packing | Drug: levobupivacaine<br>* in nasal packing<br>|
| Active Comparator: fentanyl +levobupivacaine<br>fentanyle with levobupivacaine for pain of nasal packing | Drug: Fentanyl + Topical Levobupivacaine<br>* in nasal packing<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| postoperative pain by visual analoge score | assessment of pain on removal of nasal packing after endoscopic nasal surgery by VAS score. The Visual Analogue Scale (VAS) (0, no discomfort and no pain; 10, a high level of discomfort and maximum pain) | 24 houres postoperative pain assessment |
Influencing Factors on Dry Eye Syndrome and Ocular Surface Disease

Study Overview
=================
Brief Summary
-----------------
Dry eye syndrome and ocular surface disease are very important ophthalmologic diseases. It is known that various inducers are involved. However, it is still necessary to study how influencing factors are related to dry eye syndrome and ocular surface disease and how treatment for dry eye syndrome and ocular surface disease is helpful.

Official Title
-----------------
Prospective Study for Influencing Factors on Dry Eye Syndrome, Ocular Surface Disease and Treatment

Conditions
-----------------
Dry Eye Syndrome, Ocular Surface Disease

Intervention / Treatment
-----------------
* Other: Observation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with ocular discomfort related to DED who visit the Hallym University Kangnam Sacred Heart Hospital between June 2016 and June 2017. Exclusion Criteria: Subjects who are elderly (≥80 years old) or have an autoimmune disease (e.g., Sjögren's syndrome and systemic lupus erythematosus) are excluded.

Ages Eligible for Study
-----------------
Minimum Age: 19 Years
Maximum Age: 79 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Dry eye syndrome<br> | Other: Observation<br>* Observation<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ocular surface disease index | The ocular surface disease index survey in completed at the time of the exam. This scale ranges from 0 to 100 higher scores representing greater disability. | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Tear break-up time |  | 1 day | 
| Schirmer tear secretion test | Schirmer tear secretion test (mm) without anesthesia was performed using strip (Color Bar; Eagle vision. Memphis, TN) | 1 day | 
| Corneal fluorescence staining | Corneal staining with fluorescein solution is graded at the time of the exam on a scale of 0 to 5 using the oxford scoring system with 5 being the most severe staining. | 1 day |
Effect of Exercise Training in Autonomic Modulation in Breast Cancer Patients

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to evaluate the effect of exercise training in the autonomic nervous system activity in breast cancer patients, who underwent doxorubicin medication.

Official Title
-----------------
Effect of Exercise Training in Autonomic Modulation in Breast Cancer Patients Treated With Doxorubicin

Conditions
-----------------
Breast Neoplasms, Autonomic Nervous System Diseases

Intervention / Treatment
-----------------
* Other: Combined Exercise Training


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Breast cancer patients at stages 1, 2 and 3; Sedentary; Currently at treatment; 4-6 months after surgery Exclusion Criteria: Musculoskeletal injuries or disorders; Mental illnesses Stage 4 (Metastasis) Enrolled in other exercise program

Ages Eligible for Study
-----------------
Minimum Age: 30 Years
Maximum Age: 59 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Control<br>This group do not participated in the intervention protocol (exercise training), and was followed throughout the entire process. Autonomic activity was assessed before and after 4 weeks. | |
| Active Comparator: Exercise Training<br>This group undergone exercise training intervention during 4 weeks. | Other: Combined Exercise Training<br>* This intervention consisted in 4 weeks of strength, flexibility and aerobic exercises made at the hospital and at home.<br>* Other names: Exercise;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Reduction in Low Frequency Heart rate variability component (LF) | This reduction is positive, indicating a reduction in sympathetic activity and thus the cardiovascular risk | 4 weeks | 
| Increase in High Frequency heart rate variability component (HF) | Means a increase in parasympathetic activity, which is correlated to reduction in cardiovascular risk | 4 weeks |
Study of Collagen Membrane in Guided Bone Regeneration

Study Overview
=================
Brief Summary
-----------------
The main purpose of this study is to investigate the efficacy of Hypro-Sorb® F, a bilayered bioabsorbable membrane in inducing bone regeneration in different dental procedures requiring GBR.

Detailed Description
-----------------
Guided bone regeneration is a procedure used in dentistry for the reconstruction of osseous defects around teeth, dental implants, and prior to implant placement. The main function of the membrane barrier in GBR is to mechanically prevent the undesirable penetration of epithelial cells and fibroblasts to the bone defect area, creating a secluded space where bone regeneration may occur. Resorbable and non-resorbable membranes have been used in GBR. While non resorbable membranes require another surgical procedure for removing the membrane after the healing period, the resorbable membranes have the advantage of transmitting tissue fluids, excluding undesirable cell penetration and sparing an additional unwanted surgical procedure. The aim of this study is to investigate the efficacy of Hypro-Sorb® F, a bilayered bioabsorbable membrane in inducing bone regeneration in different dental procedures requiring GBR.

Official Title
-----------------
Preliminary Study of Hypro-Sorb® F Bilayer Bioabsorbable Membrane for Guided Tissue and Bone Regeneration

Conditions
-----------------
Sinus Lift, Periimplantitis, Cystectomy, Segmental Growing of Alveolar Tissue, Root Amputation and Apicoectomy

Intervention / Treatment
-----------------
* Device: HYPRO SORB F


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Cystectomy Segmental growing of alveolar tissue Lifting of the sinus bottom Root amputation Apicoectomy Filling of the alveolus after resections in prosthetic surgical practice Periimplantitis Maxillofacial surgery Exclusion Criteria: Inside bone fractures when acrylate adhesives are applied.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: HYPRO SORB F|resorbable, double layered, collagen membrane|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| expected |  | 2 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
cystectomy, augmentation, sinus, amputation, implant
One Year Clinical Evaluation of IPS Empress CAD Versus Polished Celtra Duo Ceramic Laminate Veneers

Study Overview
=================
Brief Summary
-----------------
When restoring teeth with IPS Empress laminate veneers, fracture of restorations may occur. So, material with higher mechanical properties is required. Celtra Duo is a new material with glass ceramics infiltrated by 10% zirconia particles which increase the fracture resistance of the material.

Official Title
-----------------
One Year Clinical Evaluation of IPS Empress CAD Versus Polished Celtra Duo Ceramic Laminate Veneers

Conditions
-----------------
Diastema, Tooth Discoloration, Tooth Fractures

Intervention / Treatment
-----------------
* Other: IPS Empress CAD
* Other: polished Celtra Duo


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All subjects are required to be: From 18-50 years old, be able to read and sign the informed consent document. Have no active periodontal or pulpal diseases, have teeth with good restorations Psychologically and physically able to tolerate conventional dental procedures Patients with teeth problems indicated for laminate veneer: Discoloration Fracture not involving more than 50% enamel loss Mild malposition Diastema Enamel fluorosis Stained or defective restorations Able to return for follow-up examinations and evaluation Exclusion Criteria: Patient with post and core endodontically treated teeth Patient with fractured teeth of more than 50% enamel loss Patients with poor oral hygiene and motivation Pregnant women's Patients in the growth stage with partially erupted teeth Psychiatric problems or unrealistic expectations Lack of opposing dentition in the area of interest Patients involved in contact sports Teeth with deep discoloration

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: IPS Empress CAD<br>Leucite Based glass Ceramics which is etchable ceramics and proved to have good success rate if used for laminate veneers | Other: IPS Empress CAD<br>* standard etchable glass ceramics<br>* Other names: leucite based glass ceramics;|
| Experimental: polished Celtra Duo<br>Zirconia reinforced lithium silicate, it is a recent material with glass ceramics enriched with 10% zirconia that offers high strength properties | Other: polished Celtra Duo<br>* new glass ceramic material<br>* Other names: zirconia reinforced lithium silicate (ZLS);|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fracture | number of fractured laminates | 1 year |