Exercise Training in Patients With Rheumatoid Arthritis and Cryotherapy

Study Overview
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Brief Summary
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The main objective of this project is to study, in patients with rheumatoid arthritis, the effects of an intermittent type exercise associated with cryotherapy on the level of inflammation during its recovery.

Official Title
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Exercise Training in Patients With Rheumatoid Arthritis and Cryotherapy: Feasibility Study

Conditions
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Arthritis, Rheumatoid

Intervention / Treatment
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* Other: constant exercise
* Other: cryotherapy
* Other: intermittent exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Men and women >18 years old, < 80 years old Signature of informed consent for participation Affiliation to a social security scheme or French beneficiary of such a regime. confirmed rheumatoid arthritis and monitoring by the rheumatology department of the University Hospital of Besancon. If there is a corticosteroid therapy, it must be stable for at least 1 month and less than or equal to 10 mg of prednisone equivalent per day Clinical and biological activity will be moderate (ie not in remission and not severe based on Disease Activity Score 28 joints - DAS 28 - to be between 2 and 6 Patients could be treated with DMARDs (Disease-Modifying Drugs). Exclusion Criteria: Patient under guardianship, curatorship, under judicial protection, major incapable Patients whose body mass index (BMI) greater than 30, Pathology incompatible with the completion of a cycle ergometer exercise (heart, vascular, respiratory, orthopedic ...) Change in DAS28 greater than 1.2 in the previous 3 months Inclusion A patient with a DAS28 > 6 about the cold: Raynaud's syndrome, cold known allergy, sickle cell anemia, cryoglobulinemia, uncontrolled hypertension Patient unable to follow protocol because of cognitive, psychiatric or language difficulties. Inability to follow protocol for causes related to health problems (unrelated Rheumatoid Arthritis) or socio-professional.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: constant exercise without cryotherapy<br>constant exercise without cryotherapy | Other: constant exercise<br> <br> |
| Experimental: constant exercise with cryotherapy<br>constant exercise with cryotherapy | Other: constant exercise<br> <br> Other: cryotherapy<br> <br> |
| Experimental: intermittent exercise, no cryotherapy<br>intermittent exercise without cryotherapy | Other: intermittent exercise<br> <br> |
| Experimental: intermittent exercise and cryotherapy<br>intermittent exercise with cryotherapy | Other: cryotherapy<br> <br> Other: intermittent exercise<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| plasma concentration of C-reactive protein |  | 48 hours after the end of the exercise |