Evaluation of the Efficacy of Different Strategies to Treat Anemia in Mexican Children

Study Overview
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Brief Summary
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Anemia continues to be a major public health problem in many regions of the world and it is still not clear which strategy is more effective in children population in terms of adherence and efficacy. The objective was to evaluate the efficacy and acceptance of several strategies that have been recently recommended to treat anemia on anemic children (6 to 43 mo):Iron supplement, iron+folic acid supplement, a multiple micronutrients supplement a micronutrient fortified complementary food in the form of porridge powder or zinc+iron+ascorbic acid fortified water.

Official Title
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Evaluation of the Efficacy of Different Strategies to Treat Anemia in Mexican Children: A Randomized Clinical Trial

Conditions
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Anemia

Intervention / Treatment
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* Dietary Supplement: Iron
* Dietary Supplement: Multiple micronutrients supplement
* Dietary Supplement: micronutrient fortified porridge powder
* Dietary Supplement: Iron and ascorbic acid fortified water
* Dietary Supplement: Iron plus folic acid supplement


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Hemoglobin less than 11.7g/dL and above 7.0g/dL Exclusion Criteria: Breastfeeding Chronic gastroenteritis Any other severe illness

Ages Eligible for Study
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Minimum Age: 6 Months
Maximum Age: 42 Months

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Anemic children<br> | Dietary Supplement: Iron<br>* Daily 20mg of ferrous sulfate in liquid solution during 4 months<br>Dietary Supplement: Multiple micronutrients supplement<br>* Daily supplement with 10mg of iron plus several micronutrients following a formula designed to treat anemia in indigenous population in Mexico. During 4 months.<br>Dietary Supplement: micronutrient fortified porridge powder<br>* Daily powdered complementary food designed for a national program in Mexico with 10mg of iron plus several micronutrients during 4 months<br>Dietary Supplement: Iron and ascorbic acid fortified water<br>* A drink water product fortified with 6.7 mg ofiron, zinc and ascorbic acid. This product was asked to be used for drinking and for cooking for the child during 4 months.<br>Dietary Supplement: Iron plus folic acid supplement<br>* Daily liquid solution following the daily iron (12.5mg)and folic acid recommendation of UNICEF to treat anemia during 4 months<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Anemia, Iron, Children, Micronutrients