Perception of Baby's Painful Cry in fMRI

Study Overview
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Brief Summary
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Crying is the primary signaling strategy available to the human newborn for eliciting parental care. Yet, the investigators only have superficial understanding of the information carried by cries, and how this information is perceived by parents. Using modern tools of sound processing and functional Magnetic Resonance Imaging (fMRI) experiment, this study aims to investigate cry-induced brain activation in adult depending on the cry's acoustic properties expressing various degrees of stress and distress levels. For that, Adults will be tested inside a fMRI magnet to determine their brain activations elicited by different babies cries according to whether the cry was evoked in a pain situation or not. The cerebral activity will be investigated in relation to acoustic features of cries (e.g. with pitch and/or roughness variations). To test if the gender or parentally of adult listeners influence their perceptions and brain responses, the task will be applied to 2 different groups (men and women not-parents). The hypothesis is that the brain of adult listeners will be able to discriminate adequately the intensity of the pain mediated by the cries. This process should involve brain areas such as the insular and the orbito frontal cortex that are known to participate in the integration of pain intensity and pain controls. The experiment should also determine which one of the acoustic features is able to transmit pain and to recruit brain areas involved in pain processes.

Official Title
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Perception of Baby's Painful Cry: Investigation in fMRI to Neuronal Activity Related to Empathy in Adults

Conditions
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Magnetic Resonance Imaging, Neuronal Activity

Intervention / Treatment
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* Other: functional Magnetic Resonance Imaging (fMRI)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Man or woman aged between 18 and 50 Contact-less with children right-handed Giving their written informed consent Subject who agreed to communicate MRI results to their attending physician French Social Security affiliation Exclusion Criteria: any contraindications to pass an fMRI test Pregnant woman

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: 20 men and 20 women : group non parent 20 father and 20 mother : group parent
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Men contact-less with children<br>functional Magnetic Resonance Imaging (fMRI). | Other: functional Magnetic Resonance Imaging (fMRI)<br>* During fMRI, healthy volunteers will listen 80 baby's cry.<br>* Other names: fMRI;|
| Experimental: Women contact-less with children<br>functional Magnetic Resonance Imaging (fMRI). | Other: functional Magnetic Resonance Imaging (fMRI)<br>* During fMRI, healthy volunteers will listen 80 baby's cry.<br>* Other names: fMRI;|
| Experimental: Father contact-less with children<br>functional Magnetic Resonance Imaging (fMRI). | Other: functional Magnetic Resonance Imaging (fMRI)<br>* During fMRI, healthy volunteers will listen 80 baby's cry.<br>* Other names: fMRI;|
| Experimental: Mother contact-less with children<br>functional Magnetic Resonance Imaging (fMRI). | Other: functional Magnetic Resonance Imaging (fMRI)<br>* During fMRI, healthy volunteers will listen 80 baby's cry.<br>* Other names: fMRI;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| BOLD (blood-oxygen-level dependent) -contrast imaging | Measure of blood-oxygen-level dependent with fMRI during listening to natural crying. | at inclusion | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| BOLD (blood-oxygen-level dependent) -contrast imaging | Measure of blood-oxygen-level dependent with by fMRI during listening to artificial crying. | at inclusion | 
| impact of gender and parenting on perception of baby's cry | Measure of blood-oxygen-level dependent with by fMRI during listening to artificial crying. | at inclusion | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Baby cries, pain, brain responses, neuroimaging, fMRI