the Evaluation of the Efficacy of TCI66207 on the Skin.

Study Overview
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Brief Summary
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The purpose of this study is to explore the evaluation of the efficacy of TCI66207 deep-sea live-face bacteria on the skin.

Official Title
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Evaluation of Skin Efficacy of TCI66207

Conditions
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Skin Diseases

Intervention / Treatment
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* Dietary Supplement: TCI66207 Essence
* Dietary Supplement: Placebo Essence


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy volunteers aged above 20 years old Subject has dull skin. Exclusion Criteria: .Subject with diseases of the skin, heart, liver, kidney, endocrine and other organs and patients with mental illness (according to medical history). Subjects who have known cosmetic, drug or food allergies, difficulty in digestive tract absorption or disorder. Female who is pregnant or nursing or planning to become pregnant during the course of the study. Received facial laser therapy, chemical peeling or UV overexposure in the past 4 weeks. Subjects who have large spots (area >3 square centimeter) or abnormal acne.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: TCI66207 Essence<br>Essence | Dietary Supplement: TCI66207 Essence<br>* Use it twice a day after washing your face in the morning and evening for a total of 4 weeks.<br>|
| Placebo Comparator: Placebo Essence<br> | Dietary Supplement: Placebo Essence<br>* Use it twice a day after washing your face in the morning and evening for a total of 4 weeks.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The change of skin moisture | Corneometer® CM825 was utilized to measure skin moisture. Units: arbitrary Corneometer® units 0-120 | Subjects will be tested in the 4th week. | 
| The change of skin elasticity | Cutometer® dual MPA 580 was utilized to measure skin elasticity (parameter R2). Units: μm penetration depth into the probe opening, expressed as curvesCorneometer® units 0-120 | Subjects will be tested in the 4th week. | 
| The change of skin wrinkles | VISIA Complexion Analysis System was utilized to measure wrinkles. Units: arbitrary units | Subjects will be tested in the 4th week. | 
| The change of skin collagen density | DermaLab® USB - 20 MHz High Freq. Ultrasound probe was utilized to scan and analyze skin collagen density. Units: Intensity score | Subjects will be tested in the 4th week. | 
| The change of skin texture | VISIA Complexion Analysis System was utilized to measure skin texture. Units: arbitrary units | Subjects will be tested in the 4th week. | 
| The change of skin pores | VISIA Complexion Analysis System was utilized to measure skin texture. Units: arbitrary units | Subjects will be tested in the 4th week. |