Tracking of Upper Limb Sensory and Motor Recovery in Asian Stroke Survivors

Study Overview
=================
Brief Summary
-----------------
As Singapore's population is aging rapidly, the incidence rate of stroke has been increasing in the past years. Rehabilitation is essential for the resumption of daily activities, and with the appropriate care, it is possible for stroke-survivors to regain most of their functions. Hence, this study aims to better understand upper limb recovery covering different stages post-stroke in a representative cohort of Asian adults

Detailed Description
-----------------
Stroke is a leading contributor to disability in Singapore, partially driven by a reduced ability to use the upper limb in their daily lives. Reduced upper limb use commonly results from a variety of impairments such as motor, sensory and cognitive impairments. The aim of this longitudinal and observational study is to gather a rich multi-modal database on the time-course of upper limb recovery in a representative cohort after stroke and characterise the relationship between upper limb recovery, common post-stroke impairments and quality of life.

Official Title
-----------------
Deep Phenotyping of Upper Limb Sensori-motor Recovery in Asian Stroke Survivors: Concept, Development and Implementation of a Rehabilomics-driven Technology-assisted Data Platform

Conditions
-----------------
Stroke

Intervention / Treatment
-----------------
* Other: Clinical and technological-aided assessments and questionnaires


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Stroke confirmed by neurologists, neurosurgeons and brain imaging (CT, CT angiogram, MRI, MR angiogram) First ever confirmed stroke Asian ethnicity Age 21-90 years Montreal Cognitive Assessment (MOCA) scores 21/30 and above Admission to rehabilitation ward is within 8 weeks of stroke onset Exclusion Criteria: Recurrent stroke or transient ischaemic attack (TIA) Upper limb impairment not related to stroke: e.g., subarachnoid haemorrhage, traumatic brain injury or brain tumours Bilateral upper limb impairment. Uncontrolled medical conditions such as hypertension, hypotension, diabetes mellitus, unstable angina, cardiac failure or sepsis will be excluded. Active fractures or arthritis of upper limb joints/bones Visual Analogue Scale (VAS) pain > 5/10 MOCA < 21/30 Severe behavioural disturbance or agitation or epilepsy or untreated depression Life expectancy < 6 months End organ failures on replacements (renal dialysis or renal replacement therapies) Minimally responsive or unresponsive awareness (vegetative) states Pregnancy or lactation states Admission to rehab ward later than 8 weeks post-stroke (For TMS assessments only) History of epilepsy or seizures, or cranial surgeries, or have metal implants in body or head, or have implanted electronics, or have metallic valve, or skull fracture or brain injury, or head or brain surgeries.

Ages Eligible for Study
-----------------
Minimum Age: 21 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Intervention<br> | Other: Clinical and technological-aided assessments and questionnaires<br>* Assessments and questionnaires related to upper limb function and quality of life will be used<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fugl-Meyer Assessment (FMA) | The FMA-UE is a stroke-specific, performance-based impairment index. It is designed to assess motor functioning, balance, in patients with post-stroke hemiplegia. | Inpatient: week 1 of admission |