Evaluation of Liver Fibrosis With 2D-Shear Wave Elastography

Study Overview
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Brief Summary
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The aims of this study are to evaluate liver fibrosis with two-dimensional (2D) shear wave elastography (SWE) technique in inactive hepatitis B surface antigen (HBsAg) carriers and patients with active chronic hepatitis B (CHB), with the help of a propagation map, compare this method with histopathological results in patients with CHB and determine the suitability of 2D-SWE for use instead of liver biopsy by evaluating fibrosis before and after treatment.

Detailed Description
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A total of 253 patients with CHB and inactive HBsAg carriers as well as a control group of 30 healthy individuals were included in the study between January 2019 and October 2020. Liver stiffness measurements with 2D-SWE, fibrosis-4 (FIB-4) and aspartate aminotransferase to platelet ratio index (APRI) scoring and additional liver biopsy in patients with CHB were performed in all cases with the help of the propagation map. Depending on the degree of fibrosis, liver stiffness was measured again at 24 and 48 weeks in patients who received antiviral therapy. Spearman rank correlation test was used for analysing correlation between variables, and receiver operating curve analysis was used to evaluate diagnostic performance in terms of fibrosis.

Official Title
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Evaluation of Liver Fibrosis in Chronic Hepatitis B Patients With 2D Shear Wave Elastography With Propagation Map: A Single Center Study

Conditions
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Chronic Hepatitis B, Sonoelastography, Fibrosis, Liver

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Being infected with the hepatitis B virus, > 18 years old < 64 years old Exclusion Criteria: Co-infection with hepatitis C or D Have chronic or acute fulminant liver disease Have DM disease Hypertriglyceridemia, obesity, grade2 and higher hepatosteatosis, Long-term drug use, alcohol intake that may damage the liver Under the age of eighteen Over sixty-five years old Transplantation patients

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group 1<br>Inactive HBsAg carriers were patients with HBsAg positivity for more than 6 months | |
| Group 2<br>Patients diagnosed with chronic hepatitis B were patients with HBsAg positivity for more than 6 months | |
| Group 3<br>The control group was composed of healthy individuals who were not infected with hepatitis B virus and did not fit any exclusion criteria. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of liver stiffness levels of group 1 and group 2 patients | Liver stiffness levels of group 1 and group 2 patients were compared by measuring in kPa and m / s using 2D-SWE technique. Possible increase and decrease values in liver stiffness measurements were calculated at 24 and 48 weeks in subjects who received antiviral therapy. | 1st week, 24th week and 48th week | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Shear wave elastography, Propagation map, Chronic Hepatitis, Liver fibrosis