Schizophrenia Sensory Gating Deficit With Quetiapine

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is the use of magnetoencephalography or MEG (a machine that measures magnetic activity in your brain) and electroencephalography or EEG (a technique that measures electrical activity in your brain) to study how sounds are processed in individuals with schizophrenia after three months of taking the antipsychotic medication quetiapine.

Detailed Description
-----------------
.Problems with attention and perception are core features of schizophrenia and are hypothesized to result from defects in the filtering or gating of sensory input. Examination of this requires neuoimaging techniques with high temporal resolution. High-density EEG and MEG in combination with structural magnetic resonance imaging (sMRI) are used to map sensory gating. In a number of recent studies patient treated with novel antipsychotics have been shown to have P50 gating ratios resembling those of normal controls rather than that of schizophrenia subjects treatment with conventional antipsychotics. To date, there is no literature on the effects of quetiapine on sensory gating. Subjects who meet all inclusion criteria and have been on a stable dose of quetiapine for three months will receive a clinical interview, an MRI, MEG, and neuropsychological testing to determine if patients with schizophrenia who are treated with quetiapine will demonstrate a sensory gating ratio similar to normal controls, indicating no deficit in sensory gating.

Official Title
-----------------
Schizophrenia Sensory Gating Deficit With Quetiapine

Conditions
-----------------
Schizophrenia

Intervention / Treatment
-----------------
* Drug: Quetiapine


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patient Population Diagnosis of Schizophrenia as determine by the Structured Clinical Interview for DSM-IV No comorbid diagnosis of PTSD responders to quetiapine, determined by continuous treatment at the same dose of quetiapine and absence of psychiatric hospitalization for at least 3 months No history of drug dependency in their lifetime No history of alcohol or other substance abuse in the 6 months prior to entry into the study No history of head injury with loss of consciousness for more than 5 minutes No history of seizure disorder No mood stabilizing agents Between 18-65 and Able to sign informed consent Normal Controls Matched in age and gender to patient population No history of psychiatric dysfunction or alcohol or other substance dependence in their lifetime as determine by the SCID No history of alcohol or other substance abuse in the previous 6 months No family history of psychotic disorder in first degree relatives as assessed by the FH-RDC diagnostic interview No history of head injury with loss of consciousness for more than 5 minutes No history of seizure disorder Between 18-65 Able to sign informed consent Exclusion Criteria: Subjects will be excluded from participating in this study if they: Require treatment with a mood stabilizer Have had an inpatient hospitalization in the past 3 months Have a history of a neurological disorder Have any other axis I diagnosis besides schizophrenia

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Quetiapine|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Psychiatry, Antipsychotic, Psychopharmacology, Clinical Trial, Open Label, Schizophrenia, Sensory Gating, Attention, Memory