Epidemiological Multicohort Study of Latent COVID-19 Infections

Study Overview
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Brief Summary
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Cross-sectional study to detect latent COVID-19 infections in residents and staff of old people's and nursing homes in the city of Solingen with a prospective follow-up of 6 months in a subgroup.

Detailed Description
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Particular interest is being paid to old people's and nursing homes during the COVID-19 pandemic, as people at particular risk are to be found there. Therefore, the health department of the city of Solingen will carry out extensive testing of both staff and residents for COVID-19 in this sensitive area. The scientific institute Bethanien für Pneumologie e.V. would like to collect and evaluate the data and test results collected in the process in order to record the occurrence of infections in this area and to obtain information on possible routes of infection and the effectiveness of hygiene measures taken. The aims of the study are: Prevalence of latent COVID-19 infections at one point in time among residents and staff of old people's and nursing homes in Solingen. Prevalence of latent COVID-19 infections over a period of 6 months among staff of a single nursing home (=subgroup) Analysis of transmission pathways of the virus in a nursing home Analysis of the effectiveness of hygiene measures taken Analysis of risk factors (previous illnesses, medication, etc.)

Official Title
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Epidemiological Multicohort Study of Latent COVID-19 Infections in Residents and Staff of Nursing Homes in the City of Solingen

Conditions
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COVID-19

Intervention / Treatment
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* Diagnostic Test: COVID-19 nasal/pharyngeal swab


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: informed consent of the test person or the legally authorised guardian Exclusion Criteria: missing consent

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| residents and staff of all nursing homes in Solingen<br>each study participant receives a single nasal/pharyngeal swab | Diagnostic Test: COVID-19 nasal/pharyngeal swab<br>* each study participant receives a nasal/pharyngeal swab<br>|
| staff of one single nursing home in Solingen<br>each study participant receives a weekly nasal/pharyngeal swab for six months | Diagnostic Test: COVID-19 nasal/pharyngeal swab<br>* each study participant receives a nasal/pharyngeal swab<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prevalence of latent COVID-19 infections at one point in time among residents and staff of all old people's and nursing homes in Solingen. | number of positive COVID-19 tests | baseline | 
| Prevalence of latent COVID-19 infections over a follow-up period of 6 months among staff of one single nursing home | number of positive COVID-19 tests | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Analysis of risk factors (previous illnesses, medication...) | analysis of risk factors for a COVID-19 infection | 6 months |