PremCry Study : Study of Ontogeny of Crying in Preterm Infants.

Study Overview
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Brief Summary
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Crying is a survival mechanism for babies and their almost exclusive means of expression until the age of 4 months. Babies 'cry is mostly related to pain, a feeling of hunger, discomfort or separation following the departure of a parent around. Crying is a complex but essential means of communication and information between a baby and his parents that raises the question of their meaning. Very few longitudinal studies have been produced on preterm's crying. As the term approaches, the characteristics of preterm babies' crying are similar to those of term infants. But these studies date back more than 30 years and are obsolete in terms of the quality and performance of sound recording equipment and signal processing. No study has looked at the genesis of the cry itself and the varieties of the cry of the preterm baby, depending on whether it was in a situation of hunger, pain, discomfort (bath).

Detailed Description
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This longitudinal study recordings of crying babies from 26 amenorrhea week to 33 amenorrhea week, 24 hours per week, each week until the return home. In the same time, parents will be asked to know the situation of the baby (hunger, pain, bath).

Official Title
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PremCry Study : Study of Ontogeny of Crying in Preterm Infants.

Conditions
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Preterm Birth

Intervention / Treatment
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* Other: cries longitudinally registered


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Infant born between 26 and 33 amenorrhea week Live infant at birth Parent affiliated or entitled to a social security scheme Parent who received informed written information about the study Exclusion Criteria: - Intubated infant

Ages Eligible for Study
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Minimum Age: 1 Day
Maximum Age: 10 Days

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Preterm infant<br> | Other: cries longitudinally registered<br>* Their cries will be longitudinally registered from the age of birth to the return home using an automatic record device: Song Meter SM4.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Analysis fundamental frequency (f0) | Measured by PRAAT software for 24h every week | at the end of hospitalization (on average 2 months) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Analysis roughness of the cry (PC1) | Measured by PRAAT software for 24h every week | at the end of hospitalization (on average 2 months) | 
| Analysis pitch of the cry (PC2) | Measured by PRAAT software for 24h every week | at the end of hospitalization (on average 2 months) | 
| Analysis NIP∑ (neonatal index of parasympathetic activity) index | Measured by monitor MDoloris® for 24h every week | at the end of hospitalization (on average 2 months) | 
| Correlation between crying acoustic structures and parent's responses | Measured by completed questionnaire by parents (Linear Mixed Model) every week | at the end of hospitalization (on average 2 months) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Newborn, ontogeny of crying, preterm infants