Ultrasonography Guided Brain Lesions Resection:

Study Overview
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Brief Summary
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Evaluate the clinical value of intraoperative ultrasonography as a real-time guidance Combination of data of MRI Tractography and intra operative ultrasonography will be useful in good localization of lesions or not . Maximal safe resection .

Detailed Description
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Accurate pre and intraoperative localization of Brain lesions is a challenge in neurosurgery specially deep intra cerebral lesions. Stereotaxy and neuronavigator played a major role in preoperative and intraoperative evaluation of exact location of intra cerebral lesions, the main drawbacks of using steriotaxy and neuronavigator that they are time consuming, complicated and expensive.(1) Nowadays we use MRI Tractography as preoperative imaging to localize lesions and there relation to neural tracts specially in eloquent brain areas, and also intraoperative ultrasonography Which act as a real-time, unexpansive and relatively simple tool for intraoperative visualization of the lesion's location, size, extent and its relationship with the surrounding tissue, also it can reveal the lesion's blood supply, it can measure the rate and direction of arterial blood flow.(2,3,4) Intraoperative ultrasonic imaging was first applied as a real-time navigation system in neurosurgery in 1980. (5) In this research we will combine the use of preoperative MRI tractography with intra operative ultrasonography in accurate localization of brain lesions and its relation with important tracts and if this combination will be beneficial and add to the safety of excision of lesions or not.

Official Title
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Ultrasonography Guided Brain Lesions Resection: a Tool for a Real Time Intraoperative Neuronavigation

Conditions
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Patients Who Are Diagnosed to Have Intracranial Lesions

Intervention / Treatment
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* Device: use of intraoperative ultrasound


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients who are diagnosed to have Intracranial lesions Patients with recurrent lesions Exclusion Criteria: Patients who are unfit for surgery Patients who have multifocal lesions

Ages Eligible for Study
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Minimum Age: 1 Month
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: use of intraoperative ultrasound|Ultrasonography guided brain lesions resection intra operatively for good localization|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Extent of resection of the lesion | Extent of resection of the lesion evaluated by comparing pre operative and post operative MRI | 48 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| post operative complication | post operative complication evaluated by full neurological examination | one month |