Advanced Magnetic Resonance Imaging in Temporal Lobe Epilepsy

Study Overview
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Brief Summary
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We aim to o evaluate the role of conventional and advanced MRI sequences in diagnosis of idiopathic temporal lobe epilepsy including identification and lateralization of epileptogenic focus.

Detailed Description
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Patients with history of partial seizures with or without secondary generalization attending at outpatient clinic or admitted at Neurology department of Assuit University Hospital will be included in the study MRI study will be done for each patient. MR imaging will be performed on a 1.5-T MR imaging unit (Siemens, Sembra medical system,German). Prospectively completed data forms will be analyzed and compared. Statistical tests appropriate to the nature of the data will be used. All patients will not be subjected to risk of any kind during this study. All patients' data will be confidentially kept. Approval of the ethical committee of Faculty of Medicine, Assiut University. An informed consent will be taken from all patients included in this study. The research will be conducted only by scientifically qualified and trained personnel. The procedures included in this study have been already used in hospital and centers in and outside Egypt

Official Title
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Role of Advanced Magnetic Resonance Imaging in Diagnosis of Idiopathic Temporal Lobe Epilepsy

Conditions
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Temporal Lobe Epilepsy

Intervention / Treatment
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* Device: MRI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients with history of partial seizures with or without secondary generalization attending at outpatient clinic or admitted at Neurology department of Assuit University Hospital will be included in the study based on the following criteria: Clinical features consistent with seizures of temporal lobe origin. Focal ictal temporal lobe patterns recorded with EEG. No lesion detected by conventional MR imaging other than mesial temporal sclerosis. Exclusion Criteria: Any general contraindication of MRI in some cases as presence of para magnetic substance as pacemakers or in patients with claustrophobia. Subjects with age less than 12 year old. Patients with any structural lesion other than mesial temporal sclerosis identified on MR brain imaging.

Ages Eligible for Study
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Minimum Age: 12 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: MRI|Magnetic resonance imaging with advanced sequences including volumetry, spectroscopy and tractograpghy.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Calculating the sensitivity,specificity and accuracy of hippocampal volumetry , T2 relaxometry , MR spectroscopy and diffusion tensor imaging in identification and lataeralization of epileptogenic focus | Quantification of hippocampal volumes bilaterally by mean of hippocampal volumetry Change in metabolites ratio at the affected hippocampus by mean of MR spectroscopy | baseline |