Mother-infant Microbiota Transmission and Its Link to the Health of the Baby

Study Overview
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Brief Summary
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The human intestinal tract harbors a diverse and complex microbial community, known as gut microbiota, which is critical in sustaining physiology, metabolism, nutrition and immune function. Dysbiosis of gut microbiota has been linked with obesity, hyperglycemia, hyperlipidemia, inflammatory bowel disease and other chronic inflammatory diseases. Gut microbiota is affected by host genetic markup, diet and life style; and therefore varied by human races and geographical locations. The development of gut microbiota starts before birth. The infant's microbiome can impact on human health in later life. The microbiome of pregnant women are associated with early-life microbiota of their offspring as well as growth, neurodevelopment and the development of allergic and neurocognitive disorders. Early childhood, when the microbiota is less mature and more malleable, is a golden age for microbiota manipulation to prevent disease. Studying microbiota at this golden age also allow us to dissect the development of a faulty microbiota and identify therapeutic targets to reverse it and cure diseases that are already developed.

Official Title
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Mother-infant Microbiota Transmission and Its Link to the Health of the Baby

Conditions
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Gut Microbiome, Mother to Child Transmission

Participation Criteria
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Eligibility Criteria
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Pregnant women Inclusion Criteria: Being pregnant Plan to give birth in local hospital Competent to provide informed consent (no mental illness or dementia, etc. that will hinder their ability to undertake informed consent) Plan to stay in the same local area for at least 7 years post-delivery Exclusion Criteria: No New Born Baby Inclusion Criteria Be a new born baby of an enrolled pregnant woman One of the parents or legal guardian is competent to provide informed consent (no mental illness or dementia, etc. that will hinder their ability to undertake informed consent) Exclusion Criteria: No Father of new born baby Inclusion Criteria Biological father of an enrolled new born baby Competent to provide informed consent (no mental illness or dementia, etc. that will hinder their ability to undertake informed consent) Exclusion Criteria: No
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Pregnant women<br>Women who are being pregnant and plan to give birth in local hospital. Pregnant women who plan to stay in the same local area for at least 7 years post-delivery. | |
| New Born Baby<br>new born baby of an enrolled pregnant woman. | |
| Father of new born baby<br>Biological father of an enrolled new born baby. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Develop a 100,000 pair of mother-baby longitudinal cohort | Set up a large scale database to collect data such as comprehensive clinical data, such as mother's and father's demographic and clinical information (e.g. age, weight, gender, family medical history, dietary, drug usage etc.) | 8 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Dissect the important microbiome that maintain health | Study samples will be collected to characterize which microbiota will be transmitted from mother to baby by performing metagenomics of gut microbiome in stool and other samples | 8 year | 
| Seize the golden period of early life for prevention of human diseases | Study samples will be collected to characterize which microbiota induces disease by performing metagenomics of gut microbiome in stool and other samples and develop treatment with microbiota. | 8 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Mommy