Carboplatin and Paclitaxel With or Without Bevacizumab in Treating Patients With Newly Diagnosed Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cavity Cancer

Study Overview
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Brief Summary
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RATIONALE: Drugs used in chemotherapy, such as carboplatin and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or stopping them from dividing. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Bevacizumab may also stop the growth of tumor cells by blocking blood flow to the tumor. It is not yet known whether giving carboplatin and paclitaxel together with bevacizumab is more effective than carboplatin and paclitaxel alone in treating patients with ovarian epithelial cancer, fallopian tube cancer, or primary peritoneal cavity cancer. PURPOSE: This randomized phase III trial is studying carboplatin, paclitaxel, and bevacizumab to see how well they work compared with carboplatin and paclitaxel alone in treating patients with newly diagnosed ovarian epithelial cancer, fallopian tube cancer, or primary peritoneal cavity cancer.

Detailed Description
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OBJECTIVES: Primary Compare the progression-free survival and overall survival of patients with newly diagnosed ovarian epithelial, fallopian tube, or primary peritoneal cavity cancer treated with carboplatin and paclitaxel with vs without bevacizumab. Secondary Compare the response rate in patients treated with these regimens. Compare the duration of tumor response in patients treated with these regimens. Compare the biological progression-free interval, as measured by increasing CA 125 levels, in patients treated with these regimens. Compare the safety (e.g., adverse events, laboratory results, and performance status) of these regimens in these patients. Compare the quality of life of patients treated with these regimens. Compare the cost-effectiveness of these regimens in these patients. OUTLINE: This is a multicenter, open-label, randomized, controlled study. Patients are stratified according to FIGO stage (stage I-III with residual disease ≤ 1 cm vs stage I-III with residual disease > 1 cm vs stage IV disease), intended time to start chemotherapy after surgery (≤ 4 weeks vs > 4 weeks), and participating center. Patients are randomized to 1 of 2 treatment arms. Arm I (control): Patients receive paclitaxel IV over 3 hours followed by carboplatin IV over 30-60 minutes on day 1. Treatment repeats every 3 weeks for up to 6 courses in the absence of disease progression or unacceptable toxicity. Arm II: Patients receive bevacizumab IV over 30-90 minutes followed by paclitaxel IV over 3 hours and carboplatin IV over 30-60 minutes on day 1. Treatment repeats every 3 weeks for up to 6 courses in the absence of disease progression or unacceptable toxicity. Patients then continue to receive bevacizumab alone every 3 weeks for 12 courses. Quality of life is assessed at baseline, before every course, every 6 weeks for 1 year, every 3 months until disease progression or for up to 2 years, and then at 3 years. Health economic data is assessed periodically, including days of inpatient hospitalization visits, outpatient visits, and use of anticancer therapies. After completion of study treatment, patients are followed every 3-6 months for 5 years and then annually thereafter. Peer Reviewed and Funded or Endorsed by Cancer Research UK.

Official Title
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ICON7 - A Randomised, Two-Arm, Multi-Centre Gynaecologic Cancer InterGroup Trial of Adding Bevacizumab to Standard Chemotherapy (Carboplatin and Paclitaxel) in Patients With Epithelial Ovarian Cancer

Conditions
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Fallopian Tube Cancer, Ovarian Cancer, Primary Peritoneal Cavity Cancer

Intervention / Treatment
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* Biological: bevacizumab
* Drug: carboplatin
* Drug: paclitaxel
* Other: questionnaire administration
* Other: study of socioeconomic and demographic variables
* Procedure: quality-of-life assessment


Participation Criteria
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Eligibility Criteria
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DISEASE CHARACTERISTICS: Histologically confirmed ovarian epithelial, fallopian tube, or primary peritoneal cavity cancer Newly diagnosed disease Meets 1 of the following staging criteria: High-risk stage I or IIA disease (grade 3 disease or clear cell carcinoma only) Stage IIB-IV disease (all grades and all histological types) Must have undergone initial surgery (e.g., debulking cytoreductive surgery or a biopsy if the patient has stage IV disease) within the past 6 weeks Patients with stage IV disease for which initial surgical debulking was not appropriate are eligible provided the following criteria are met: Stage IV disease diagnosed by histology No planned surgery prior to disease progression, including interval debulking surgery Patients with prior early-stage ovarian epithelial or fallopian tube carcinoma treated with surgery alone are eligible at the time of diagnosis of abdominopelvic recurrence provided no further interval cytoreductive therapy is planned prior to disease progression Synchronous primary endometrial carcinoma or a past history of primary endometrial carcinoma allowed provided the following criteria are met: Disease ≤ stage IB No more than superficial myometrial invasion No lymphovascular invasion Not poorly differentiated (i.e., no grade 3, papillary serous, or clear cell disease) Measurable or nonmeasurable disease No ovarian nonepithelial cancer, including malignant mixed Müllerian tumors No borderline tumors (e.g., tumors of low malignant potential) No history or clinical suspicion of brain metastases or spinal cord compression CT scan or MRI of the brain is mandatory (within 4 weeks prior to randomization) in case of suspected brain metastases Spinal MRI is mandatory (within 4 weeks prior to randomization) in case of suspected spinal cord compression PATIENT CHARACTERISTICS: ECOG performance status 0-2 Life expectancy > 12 weeks ANC ≥ 1,500/mm^3 Platelet count ≥ 100,000/mm^3 Hemoglobin ≥ 9 g/dL (can be post-transfusion) INR ≤ 1.5 APTT ≤ 1.5 times upper limit of normal (ULN) Bilirubin ≤ 1.5 times ULN ALT and AST ≤ 2.5 times ULN Creatinine ≤ 2.0 mg/dL Proteinuria ≤ 1+ by urine dipstick OR ≤ 1 g by 24-hour urine collection Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception during and for ≥ 6 weeks after completion of study therapy No significant traumatic injury within the past 4 weeks No cerebrovascular accident, transient ischemic attack, or subarachnoid hemorrhage within the past 6 months No other malignancies within the past 5 years except for adequately treated carcinoma in situ of the cervix, and/or basal cell skin cancer, and/or early endometrial carcinoma No pre-existing sensory or motor neuropathy ≥ grade 2 No history or evidence of CNS disease (e.g., uncontrolled seizures) by neurological examination unless adequately treated with standard medical therapy No history or evidence of thrombotic or hemorrhagic disorders No uncontrolled hypertension (i.e., blood pressure > 150/100 mm Hg despite antihypertensive therapy) No known hypersensitivity to bevacizumab and its excipients, chemotherapy, or Cremophor EL No nonhealing wound, ulcer, or bone fracture Patients with granulating incisions healing by secondary intention with no evidence of facial dehiscence or infection are eligible but require three weekly wound examinations No clinically significant cardiovascular disease, including any of the following: Myocardial infarction or unstable angina within the past 6 months New York Heart Association class II-IV congestive heart failure Poorly controlled cardiac arrhythmia despite medication Rate-controlled atrial fibrillation allowed Peripheral vascular disease ≥ grade 3 (i.e., symptomatic and interfering with activities of daily living requiring repair or revision) No evidence of other disease or condition, metabolic dysfunction, physical examination findings, or laboratory findings that would contraindicate the use of an investigational drug or put the patient at high-risk for treatment-related complications PRIOR CONCURRENT THERAPY: See Disease Characteristics More than 4 weeks since other prior surgery or open biopsy No prior systemic therapy for ovarian cancer (e.g., chemotherapy, monoclonal antibody therapy, tyrosine kinase inhibitor therapy, or hormonal therapy) Prior adjuvant chemotherapy allowed for other malignancies (e.g., breast or colorectal carcinoma) if malignancy was diagnosed over 5 years ago with no evidence of subsequent recurrence No prior mouse CA 125 antibody No prior radiotherapy to the abdomen or pelvis More than 10 days since prior and no concurrent chronic use of acetylsalicylic acid (> 325 mg/day) Low-dose (< 325 mg/day) acetylsalicylic acid allowed More than 10 days since prior and no concurrent full-dose oral or parenteral anticoagulants or thrombolytic agents for therapeutic purposes Use of therapy for line patency allowed provided INR < 1.5 More than 30 days since prior and no other concurrent investigational agent or participation in another clinical trial No other concurrent systemic antitumor agents No concurrent surgery No concurrent maintenance chemotherapy or intraperitoneal chemotherapy (including cytotoxic chemotherapy)

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Biological: bevacizumab|nan|
|Drug: carboplatin|nan|
|Drug: paclitaxel|nan|
|Other: questionnaire administration|nan|
|Other: study of socioeconomic and demographic variables|nan|
|Procedure: quality-of-life assessment|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Progression-free survival |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Duration of overall survival |  |  | 
| Objective response rate |  |  | 
| Duration of response |  |  | 
| Biological progression-free interval as measured by increasing CA 125 levels |  |  | 
| Safety as measured by NCI CTAE version 3.0 |  |  | 
| Quality of life |  |  | 
| Health economics |  |  | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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stage IV ovarian epithelial cancer, Brenner tumor, ovarian carcinosarcoma, ovarian clear cell cystadenocarcinoma, ovarian endometrioid adenocarcinoma, ovarian mixed epithelial carcinoma, ovarian mucinous cystadenocarcinoma, ovarian serous cystadenocarcinoma, ovarian undifferentiated adenocarcinoma, stage IA ovarian epithelial cancer, stage IB ovarian epithelial cancer, stage IC ovarian epithelial cancer, stage IIA ovarian epithelial cancer, stage IIB ovarian epithelial cancer, stage IIC ovarian epithelial cancer, stage IIIA ovarian epithelial cancer, stage IIIB ovarian epithelial cancer, stage IIIC ovarian epithelial cancer, stage IA fallopian tube cancer, stage IB fallopian tube cancer, stage IC fallopian tube cancer, stage IIA fallopian tube cancer, stage IIB fallopian tube cancer, stage IIC fallopian tube cancer, stage IIIA fallopian tube cancer, stage IIIB fallopian tube cancer, stage IIIC fallopian tube cancer, stage IV fallopian tube cancer, stage IA primary peritoneal cavity cancer, stage IB primary peritoneal cavity cancer, stage IC primary peritoneal cavity cancer, stage IIA primary peritoneal cavity cancer, stage IIB primary peritoneal cavity cancer, stage IIC primary peritoneal cavity cancer, stage IIIA primary peritoneal cavity cancer, stage IIIB primary peritoneal cavity cancer, stage IIIC primary peritoneal cavity cancer, stage IV primary peritoneal cavity cancer