To Compare Intravenous and Oral Hydration of the Prevention for CIN in Elderly Patients Undergoing Intravenous CECT

Study Overview
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Brief Summary
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To Compare Intravenous and Oral Hydration of the Prevention for Contrast-induced Nephropathy in Elderly Patients Undergoing Intravenous Contrast-enhanced Computed Tomography.

Detailed Description
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The prospective multicenter randomized controlled clinical research discusses the comparison of oral and intravenous hydration for prevention of contrast-induced nephropathy in elderly patients with enhanced computed tomography, establishing a simple hydration proposal.

Official Title
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To Compare Intravenous and Oral Hydration of the Prevention for Contrast-induced Nephropathy in Elderly Patients Undergoing Intravenous Contrast-enhanced Computed Tomography： A Multi-center Randomized Control Trail

Conditions
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CIN

Intervention / Treatment
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* Procedure: enhanced computed tomography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age>21 informed consent Undergoing Intravenous Contrast-enhanced Computed Tomography Exclusion Criteria: CT enhancement was not performed; Dialysis treatment of patients with end-stage renal failure or heart, kidney transplantation; Exposure to radioactive contrast medium within 48 hours prior to or within 72 hours of examination; Acute decompensated heart failure; Allergic to radioactive contrast agent; Be subjected to life - threatening trauma; Severe infection; Surgery was performed within 2 days of CT examination. Combined with multiple myeloma, urinary obstruction, aortic dissection Can cause acute kidney injury disease; Use of aminoglycosides and other nephrotoxic drugs 2 weeks before.

Ages Eligible for Study
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Minimum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: distilled water<br>Oral distilled water at the rate of 3 mL/kg/h rate during undergoing enhanced computed tomography examination before 1-2 and after 4-6 hours | Procedure: enhanced computed tomography<br>* undergoing enhanced computed tomography<br>|
| Placebo Comparator: Saline<br>intravenous saline hydration at the rate of 1 mL/kg/h rate during undergoing enhanced computed tomography examination before and after 12 hours | Procedure: enhanced computed tomography<br>* undergoing enhanced computed tomography<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| CIN | Compared with before examination, the increase of serum creatinine conforms to the diagnostic criteria of contrast induced nephropathy. | 72hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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CIN, Hydration, enhanced computed tomography