Nabothian Cyst Protects or Facilitates Against Cervical Cancer

Study Overview
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Brief Summary
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Aim of the study to asses the realition between HPV infection, Nabothian Cyst and Cervical Intraepithelial lesions or Cervical Cancer

Detailed Description
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Nabothian cysts are one of the common gynecological pathologies. They rarely have clinical significance. Transvaginal ultrasonography and magnetic resonance imaging are the most useful imaging methods for cervical cystic lesions.HPV infection is the most important factor which can cause cervical malignancy and premalignant lesions. In women between 30-65 years of age HPV-DNA testing, is used as a screening test in Turkey. In this research, the aim is to examine whether there is a connection between Naboth cysts and HPV infection in the cervix. During the examination, the swab sample required for HPV PCR testing will be taken. The number and size of Naboth cysts with vaginal USG will be noted. If the patient had colposcopy / LEEP (Loop Electrosurgical Excision Procedure), the result will be investigated and noted.

Official Title
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Naboth Kisti ve HPV pozitifliği arasındaki ilişkinin araştırılması

Conditions
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HPV Infection, Nabothian Cyst, Cervical Cancer

Intervention / Treatment
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* Other: Cervical Cancer Rate


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: To have Naboth cyst and/or HPV positivity Must be willing and able to provide informed consent Comply with the study protocol Between 25-65 age range Exclusion Criteria: To Refuse participate in our research The age under 25 and over 65 Ovarian, endometrial and vulvar malignancies Without both Naboth's cyst and HPV positivity To have LEEP/Cervical Conization before History of Cervical Dysplasia

Ages Eligible for Study
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Minimum Age: 25 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| the woman who has just HPV infection<br>the woman who is between 30-65 years old, who is participate this research, and has just HPV infection in cervix. | Other: Cervical Cancer Rate<br>* In the end of the Research, we will compare cervical cancer rates between groups<br>|
| the woman who has just nabothian cyst<br>the woman who is between 30-65 years old, who is participate this research, and has just nabothian cyst in cervix. | Other: Cervical Cancer Rate<br>* In the end of the Research, we will compare cervical cancer rates between groups<br>|
| the woman who has both nabothian cyst and HPV infection<br>the woman who is between 30-65 years old, who is participate this research, and has both nabothian cyst in cervix. | Other: Cervical Cancer Rate<br>* In the end of the Research, we will compare cervical cancer rates between groups<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Nabothian cyst affects the HPV infection in cervix | in the research, results will be compared for to figure out the relation; nabothian cyst how affects HPV infection , how causes cervical dysplasia in cervix. | through study completion, an average of 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Does the other factors(like cigarette, birth number, vaginitis) affect HPV infection and Cervical Cancer | In the research Other factors(like cigarette, birth number, vaginitis) will be also noted. These datas will be used to understand correlation; the other factors increase or decreate the rate of HPV infection and cervical dysplasia. | through study completion, an average of 1 year |