A Study on Central Transport Characteristics of Flurbiprofen Axetil in Elderly Patients

Study Overview
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Brief Summary
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The project will apply the methods of clinical observation experiment to study the central transport characteristics of flurbiprofen axetil by detecting S-flurbiprofen and R-flurbiprofen concentrations in cerebral-spinal fluid(CSF) after intravenous injection of flurbiprofen axetil in elderly patients.

Detailed Description
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The patients undergoing spinal anesthesia for lower extremity surgery will be studied. Flurbiprofen axetil 100mg will be injected intravenously. CSF 1ml and blood 2ml will be obtained simultaneously every 5 minutes after intravenous injection in 50 min( T1 T10).CSF and blood samples will be used to detected S-flurbiprofen and R-flurbiprofen concentrations by using Liquid Chromatography-Mass Spectrometry. And the CSF/blood S-flurbiprofen and R-flurbiprofen concentrations ratio were calculated.

Official Title
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A Study on Central Transport Characteristics of Flurbiprofen Axetil in Elderly Patients

Conditions
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Flurbiprofen Axetil, Cerebrospinal Fluid, Anesthesia, Spinal, Aged

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients undergoing lower extremity surgery under spinal or combined spinal-epidural anesthesia will be selected. Exclusion Criteria: asthma, liver insufficiency, renal insufficiency, peptic ulcer, allergy to NSAIDs, and a history use of NSAIDs within two weeks before operation.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| T1<br>At 5 minutes after flurbiprofen axetil injected intravenously, 7 aged patients' samples were required to be collected | |
| T2<br>At 10 minutes after flurbiprofen axetil injected intravenously, 7 aged patients' samples were required to be collected | |
| T3<br>At 15 minutes after flurbiprofen axetil injected intravenously, 7 aged patients' samples were required to be collected | |
| T4<br>At 20 minutes after flurbiprofen axetil injected intravenously, 7 aged patients' samples were required to be collected | |
| T5<br>At 25 minutes after flurbiprofen axetil injected intravenously, 7 aged patients' samples were required to be collected | |
| T6<br>At 30 minutes after flurbiprofen axetil injected intravenously, 14 patients' samples were required to be collected,including 7 younger patients | |
| T7<br>At 35 minutes after flurbiprofen axetil injected intravenously, 7 aged patients' samples were required to be collected | |
| T8<br>At 40 minutes after flurbiprofen axetil injected intravenously, 7 aged patients' samples were required to be collected | |
| T9<br>At 45 minutes after flurbiprofen axetil injected intravenously, 7 aged patients' samples were required to be collected | |
| T10<br>At 50 minutes after flurbiprofen axetil injected intravenously, 7 aged patients' samples were required to be collected | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The concentrations of S-flurbiprofen and R-flurbiprofen in plasma and CSF of all patients. | The samples will be used to be determined plasma and CSF drug concentrations. | perioperation | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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S-flurbiprofen, R-flurbiprofen, cerebrospinal fluid, aged