KIDSHEART AND BRAIN : Early EEG Surgery Congenital Heart Disease Predict Onset of Neurodevelopmental Disorders

Study Overview
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Brief Summary
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Congenital cardiopathy are frequent malformations (1/100 birth). The progress of surgery permit a survival rate at the adult age of more than 90%. The long terms consequences must be taken in account and the nerodevelopmental disorders are in first place (intelectual deficiency, autism spectrum disorders, or attention disorders) and presents in 30 to 60% of the patients (Calmant, 2015). The impact can be important on the scolarity, the studies, the professional activity and finaly on the quality of life of the patients becomming adults. The identification of the risk factors on surgery period should permit to propose the most adapted follow-up to the specifics needs of each patients. On the scientific plans, the identification of early markers on brain dammage on EEG should permit to better apprehend the physiopathologic mecanisms involved.

Detailed Description
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Interest of early EEG on congenital cardiopathy surgery to predict the neurodevelopmental disorders occurence. Congenital cardiopathy are frequent malformations (1/100 birth). The progress of surgery permit a survival rate at the adult age of more than 90%. The long terms consequences must be taken in account and the nerodevelopmental disorders are in first place (intelectual deficiency, autism spectrum disorders, or attention disorders) and presents in 30 to 60% of the patients (Calmant, 2015). The impact can be important on the scolarity, the studies, the professional activity and finaly on the quality of life of the patients becomming adults. The identification of the risk factors on surgery period should permit to propose the most adapted follow-up to the specifics needs of each patients. On the scientific plans, the identification of early markers on brain dammage on EEG should permit to better apprehend the physiopathologic mecanisms involved.

Official Title
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Intérêt de l'électroencéphalogramme précoce en Chirurgie de Cardiopathie congénitale Pour prédire la Survenue de Troubles du neurodéveloppement

Conditions
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Neurodevelopmental Disorders, Congenital Cardiomyopathy

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Child of less than 1 year admitted for cardiac surgery on extracorporal circulation on the CHU of Lille during the study period. Child with congenital cardiopathy with necessity to be operated before 1 year old. Exclusion Criteria: Child with no necessity of surgery before 1 year old. Medical history of cardiac surgery. Refusal of consent by the parents. No social security. Child not operated on the CHU of LILLE.

Ages Eligible for Study
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Minimum Age: 1 Day
Maximum Age: 1 Year

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Interest of pre and post surgery EEG on neurodevelopmental disorders | Evaluation of the interest of pre and post surgery EEG in the prediction of neurodevelopmental disorders on patients operated of congenital cardiopathy before the age of 1 year old. | Age of patient : 24 Months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Association between orality disorders and neurodevelopmental disorders | Association between the presence of pre surgery and 1 year old orality disorder and occurence of neurodevelopmental disorders. | Age of patient : 24 Months | 
| Interest of post surgery EEG neurodevelopmental disorders at 24 months old | Evaluation of the interest of 24 months old post surgery EEG in the prediction of neurodevelopmental disorders on patients operated of congenital cardiopathy before the age of 1 year old, having a normal pre surgery EEG. | Age of patient : 24 Months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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EEG, Neurodevelopmental Disorders, Congenital Cardiomyopathy, Orality Disorders