Investigation of Clinical Feature and Brain Function in Narcoleptic Patients

Study Overview
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Brief Summary
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This study evaluates the PSG and cerebral metabolism and functions in narcolepsy with/without RBD

Detailed Description
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Polysomnographic (PSG) work-up one night to record nocturnal sleep condition in narcolepsy with /without RBD and control subjects including sleep macrostructure, occurrence of sleep onset rapid eye movement period(SOREMP), sleep stages distribution, and sleep arousle and leg movement and apnea hyponea index would be calculated. Functional magnetic resonance imaging (fMRI) has been used in human to nonivasiverlyn investigate the neural mechanisms. This technique also apply to measures the variations in brain perfusion, structure and morphology in narcolepsy patients by assessing the blood oxygen level-dependent (BOLD) signal diffusion tensor imaging (DTI and voxel-based morphometry(VBM) This study compare the feature of PSG and fMRI between narcolepsy with RBD, narcolepsy without RBD, control subject to evaluates the PSG and cerebral metabolism and functions in narcolepsy with/without RBD.

Official Title
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Feature of Polysomnography and Cerebral Metabolism and Function in Narcolepsy With/Without RBD and Control Subject

Conditions
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Narcolepsy, REM Sleep Behavior Disorder

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Narcolepsy meet to the international classification of sleep disorder,3rd edition (ICSD-3) , and RBD meet to the minimal diagnostic criteria according to the international Classification of Sleep, control subjects . Exclusion Criteria: History of heart disease History of central nervous system organic psychosis AHI>15次/h History of alcohol dependence and drug abuse

Ages Eligible for Study
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Minimum Age: 10 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Narcolepsy with RBD & Control<br>Narcolepsy with REM sleep disorder lable(20) and Control subjects lable(20) | |
| Narcolepsy with /without RBD<br>Narcolepsy with REM sleep disorder lable(20) and Narcolepsy without REM sleep disorderlable (20) | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| video-polysomnographic(PSG) | video-PSG monitor sleep from 9:00pm to 6:00am | up to 100 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| multiple sleep latency test (MSLT) | MSLT in the next day of PSG record daytime sleepiness | up to 100 weeks | 
| functional magnetic resonance imaging (fMRI) | All narcolepsy with or withoutRBD accepts fMRI | up to 100 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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multiple sleep latency test, fMRI, polysomnographic