Intraoperative Cerebral and Renal Tissue Oxygen Saturation and Pediatric Living Donor Liver Transplantation Prognosis.

Study Overview
=================
Brief Summary
-----------------
This rSO2 study is a prospective clinical study. The purpose of the rSO2 study is to investigate whether there is a correlation between the intraoperative cerebral and renal tissue oxygen saturation and the incidence of developmental and socioemotional delay after living donor liver transplantation for children. This study will also investigate whether intraoperative cerebral and renal tissue oxygen saturation are related to postoperative complications.

Detailed Description
-----------------
There is high incidence of developmental and socioemotional delay and postoperative complications in pediatric living donor liver transplantation patients. In this prospective observational clinical study, the investigators aim to investigate the correlation between the intraoperative cerebral and renal tissue oxygen saturation and the incidence of developmental and socioemotional delay and postoperative complications. This study will enroll patients aged from 6 to 36 months old who are scheduled for elective standard living-donor liver transplantation and have signed informed consent before the surgery.

Official Title
-----------------
Association of Intraoperative Cerebral and Renal Tissue Oxygen Saturation With Developmental and Socioemotional Delay and Postoperative Complications After Living Donor Liver Transplantation for Children: an Observational Study.

Conditions
-----------------
Pediatric Liver Transplantation, Developmental Delay, Postoperative Complications, Socioemotional Delay

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Pediatric patients (6 months< the Moon's age <36 months) who will receive standard living-donor liver transplantation (LDLT) in Renji Hospital. Exclusion Criteria: Forehead skin infection, A history of liver transplantation, Multivisceral transplantation, Refused to participate the study

Ages Eligible for Study
-----------------
Minimum Age: 6 Months
Maximum Age: 36 Months

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Developmental delay | Developmental delay will be measured using Age and Stage Questionnaire(ASQ) after surgery. | 10days | 
| Developmental delay | Developmental delay will be measured using Age and Stage Questionnaire(ASQ) after surgery. | 1 month | 
| Developmental delay | Developmental delay will be measured using Age and Stage Questionnaire(ASQ) after surgery. | 3 months | 
| Developmental delay | Developmental delay will be measured using Age and Stage Questionnaire(ASQ) after surgery. | 6 months | 
| Developmental delay | Developmental delay will be measured using Age and Stage Questionnaire(ASQ) after surgery. | 1 year | 
| Developmental delay | Developmental delay will be measured using Age and Stage Questionnaire(ASQ) after surgery. | 2 years | 
| Developmental delay | Developmental delay will be measured using Age and Stage Questionnaire(ASQ) after surgery. | 3 years | 
| Socioemotional Delay | Socioemotional Delay will be measured using Age and Stage Questionnaire: Social Emotional(ASQ-SE) after surgery. | 10days | 
| Socioemotional Delay | Socioemotional Delay will be measured using Age and Stage Questionnaire: Social Emotional(ASQ-SE) after surgery. | 1 month | 
| Socioemotional Delay | Socioemotional Delay will be measured using Age and Stage Questionnaire: Social Emotional(ASQ-SE) after surgery. | 3 months | 
| Socioemotional Delay | Socioemotional Delay will be measured using Age and Stage Questionnaire: Social Emotional(ASQ-SE) after surgery. | 6 months | 
| Socioemotional Delay | Socioemotional Delay will be measured using Age and Stage Questionnaire: Social Emotional(ASQ-SE) after surgery. | 1 year | 
| Socioemotional Delay | Socioemotional Delay will be measured using Age and Stage Questionnaire: Social Emotional(ASQ-SE) after surgery. | 2 years | 
| Socioemotional Delay | Socioemotional Delay will be measured using Age and Stage Questionnaire: Social Emotional(ASQ-SE) after surgery. | 3 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative complications | Postoperative complications including Cardiovascular system, respiratory system, digestive system, urinary system, blood system will be screened. | 30 days |