Impulsivity and Time Perception

Study Overview
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Brief Summary
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Cannabis smokers having begun prematurely their consumption (before 16 years) present a persistent impulsivity much later after have stopped their consumptions. The literature highlights that the impulsivity promotes the passage towards a compulsive consumption, and the loss of control. To explain this phenomenon, some authors hypothesized that impulsivity would lead the subjects to overestimate the duration of events and to choose immediate rewards than preferred but delayed rewards. This hypothesis questions the role of the temporal anticipation in the impulsive choices. In a first hypothesis, the temporal impulsivity could be an endogenous deficit bound to the reward, and would be responsible for disorders of the temporal anticipation. In this case, the disorders should be observed especially when the subject anticipates a reward. Alternately, a disorder of the temporal anticipation could provoke impulsivity, and in this case, would be present with or without reward. To separate these hypotheses, we propose to test the capacities of temporal anticipation of non-smokers and early smokers of cannabis by means of a behavioral task  Hazard function task , which allow to measure the capacity of a subject to anticipate the apparition of an event on the basis of a temporal cue. The neuronal correlates will be measured by a recording EEG of the wave ' CNV ' (fix a quota for denial of variation) which reflects the temporal accumulation and the processes of anticipation.

Official Title
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Link Between Impulsivity and Time Anticipation

Conditions
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Cannabis Use

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy volunteers Man or woman of age between 18 and 50 years-old Absence of consumption of cannabis and tobacco for 1 year and absence of substance use disorder in history Matching in age and sex to the group consumers of cannabis Early consumers of cannabis (at the beginning of the consumptions before 16 years) Man or woman of age between 18 and 50 years old Statement of more than three consumptions a day of cannabis for at least one year and consumption of cannabis having begun before the age of 16 years. Urinary analysis is positive for the presence of cannabis Positive auto-questionnaire CAST: 2 positive answers to CAST questionnaire Hospitalized or not Exclusion Criteria: Presence or history of a severe and invalidating somatic pathology (neurological, cardiovascular, lung, metabolic, renal, hepatic, gastro-intestinal) History of cranial trauma with loss of consciousness. substance use disorder except the substance tested in the protocol (cannabis). Invalidating sensory disorders in particular visual: glaucoma, any retinal pathology. Visual acuteness 0.8 History of general anesthesia in the previous 3 months the study Any evolutionary neurological or psychiatric pathology Subject under guardianship pregnancy Feeding

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| P<br>for cannabis | |
| C<br>for the control group | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measure the capacities of the subjects to anticipate the apparition of the target | on the basis of a temporal cue presented before the target, and give the response as quickly as possible after the presentation of a rewarding versus not rewarding target. | 8 days after inclusion in the study | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Early onset of cannabis use, Addiction, Time perception