Multimodal Quantified Analysis of Facial Movements: Comparison Between Pathological and Control Subjects

Study Overview
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Brief Summary
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The facial palsy is a frequent disease with a lot of etiologies. It has variable severities with sometimes heavy functional repercussions and different recovery potentials. The proposed treatments are based on surgery, physiotherapy and botulinum toxin injections. However, when recovery is incomplete, acceptance is more difficult, with an impacted quality of life. Thanks to Motion Capture and Electromyography, a quantification of the facial mimicry is now possible with a great precision. In addition with the quantification of the facial mimicry, eye-tracking, wich is widely used in the marketing field, but it also finds medical applications including head and neck lesions and facial palsy in particular, will be used to evaluate the visio of the patients on their pathology in function of the movement quantification measured with MoCap and Electromyography. The aim of this research is to measure in a combined way the action potentials by sEMG and the amplitudes of displacement of the markers in motion capture, for movements determined in a population of patients presenting a facial pathology, in order to compare them with reference values obtained in healthy subjects. In a second step, the aim will be to study if there is a link between the way the patient looks at his pathology and the results of his management (treatment, rehabilitation) which will be quantitatively evaluated thanks to MoCap and sEMG.

Official Title
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Multimodal Quantified Analysis of Facial Movements: Comparison Between Pathological

Conditions
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Electromyography, Eye-tracking, Facial Palsy

Intervention / Treatment
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* Other: dental impressions
* Other: Simultaneous MoCap and EMG acquisition
* Other: Eye-tracking acquisition for pathological subjects
* Other: Follow-up visit for pathological subjects


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Subjects with no known facial pathology (healthy volunteers) OR Patients with peripheral facial palsy, irrespective of grade, whether or not previously treated Subject with written informed consent Subject over 18 years of age Subject affiliated to a social security scheme Exclusion Criteria: Subjects with severe skin disorders that do not allow the application of electrodes or photo reflective markers Subjects with speech disorders making it impossible to pronounce the sounds [o] and [pu] Subject unable to provide written informed consent Subjects under guardianship, curators or safeguard of justice

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: patients with facial palsy<br> | Other: dental impressions<br>* dental impressions<br>Other: Simultaneous MoCap and EMG acquisition<br>* Simultaneous MoCap and EMG acquisition<br>Other: Eye-tracking acquisition for pathological subjects<br>* Eye-tracking acquisition for pathological subjects<br>Other: Follow-up visit for pathological subjects<br>* Follow-up visit for pathological subjects<br>|
| Active Comparator: healthy volunteers<br> | Other: dental impressions<br>* dental impressions<br>Other: Simultaneous MoCap and EMG acquisition<br>* Simultaneous MoCap and EMG acquisition<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| determination of baseline values of facial mimicry (in millimetres) in healthy volunteers | determination of baseline values of facial mimicry (in millimetres) in healthy volunteers | one month | 
| determination of baseline values of eye-tracking (in millimetres) in healthy volunteers | determination of baseline values of eye-tracking (in millimetres) in healthy volunteers | one month | 
| determination of the maximum range of motion of facial mimicry (in millimetres) in patients | determination of the maximum range of motion facial mimicry (in millimetres) in patients | one year | 
| determination of the maximum range of motion of eye-tracking (in millimetres) in patients | determination of the maximum range of motion of eye-tracking (in millimetres) in patients | one year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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facial mimics, motion capture, electromyography, eye-tracking, Facial Palsy