Acupuncture Treatment for Improving Alzheimer's Dementia

Study Overview
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Brief Summary
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Evaluate cognitive improvement pre amd post acupuncture treatment in patients with probable alzheimer's dementia as measured by MOCA score and also per form A( measure of patient's personal information). Also caregiver input.

Detailed Description
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Patient's with diagnosis of probable mild to moderate AD will be enrolled in this study. Patient will undergo neurological examination including MOCA. Examiner will also fill out Form A at the time of initial evaluation. Patient will then undergo series of acupuncture treatments 2 per week for 6 weeks(12 acupuncture treatment). At end of this intervention patients will be reassessed using same testing(MOCA and form A) Data collected will be assessed via statistical analysis to see if there is any statistically significant improvement. Acupuncture points used in this trial will stay the same for all subjects and throughout the course. The points will be Si Shen Chong, ST36, 37, LV 2,3,6, GB 34, 39, Xia San Huang, LI 11, LI 4.

Official Title
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Clinical Trial to Measure Efficacy of Acupuncture Treatment for Alzheimer's Dementia as Measured by MOCA(Montreal Cognitive Assessment)

Conditions
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Cognitive Deficits, Alzheimer Disease

Intervention / Treatment
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* Procedure: Acupunture


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Mild to moderate AD Exclusion Criteria: Severe AD

Ages Eligible for Study
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Minimum Age: 60 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Acupuncture<br>Acupuncture 12 sessions over 6 week to be given to pateints | Procedure: Acupunture<br>* Patient will receive 12 acupuncture treatments over 6 weeks (2x per week)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Improvement on Montreal Cognitive Assessment test of 5 points or more than baseline( total score is out of 30 points) | Subject will complete 3 MOCA assessment prior to study over 1 week time. Best score of three is used. After study is complete subject will also undergo 3 MOCA assessment over 1 week immediately after study. Again best score is used. | 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Improvement of Montreal Cognitive Assessment test by category than raw total score | performance on various subcategory will also be reviewed to see if one category improves over other category. (Example: Visual-spacial parameters improves over language) | 12 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Acupunture