Nutritional Status and Hidradenitis Suppurativa (Acne Inversa)

Study Overview
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Brief Summary
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Hidradenitis suppurativa (HS) is a chronic inflammatory, debilitating skin disorder. The exacerbating factors of HS include nutrition and adiposity. The objective of this study was to investigate the relationships between body composition and the adherence to the Mediterranean diet (MD) with the severity of HS in a sample of naïve-treatment patients with HS. In the wake of this evidence, in the study to investigate the relationships between nutritional status, the adherence to the MD, body composition, and the severity of HS in a sample of naïve-treatment patients with HS compared to control group matched for sex, age, and body weight.

Official Title
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Role of Nutritionist in the Multidisciplinary Approach of Hidradenitis Suppurativa (Acne Inversa)

Conditions
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Hidradenitis Suppurativa, Mediterranean Diet, Body Composition, Vitamin D Deficiency, Trimethylamine N-oxide (TMAO)

Intervention / Treatment
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* Dietary Supplement: Mediterranean Diet


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: healthy subjects of both gender treatment-naïve patients had HS diagnosed ≥6 months before study initiation wash out therapy for at least 3 months Exclusion Criteria: occasional or current of use of drugs for HS, including topical antibiotics and systemic treatments (such as clindamycin-rifampicin, tetracycline, Rifampicin-moxifloxacin-metronidazole, ertapenem, acitretin, cyclosporine A, dapsone, isotretinoin, biologics; hypocaloric diet in the last three months or specific nutritional regimens; vitamin/mineral or antioxidant supplementation; occasional or current of use of drugs that could influence fluid balance, including non-steroidal anti-inflammatory drugs, hormone replacement therapy.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Dietary Supplement: Mediterranean Diet|We aim to determine the effects of the traditional Mediterranean Diet on Hidradenitis suppurativa|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Adherence to Mediterranean Diet by Predimed Questionnaire | Validated 14-item tool of adherence to the Mediterranean diet, with three categories of adherence (≤5, low adherence, 6-9, average adherence and ≥10 points, high adherence) | April 2015 to April 2018 | 
| Phase angle | Phase angle was performed using a BIA phase-sensitive system by experienced observers (an 800-µA current at a frequency single-frequency of 50 kHz BIA 101 RJL, Akern Bioresearch, Florence, Italy). | April 2015 to April 2018 | 
| Trimethylamine N-oxide plasma levels | ultra high-performance liquid chromatography | April 2015 to April 2018 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Vitamin D | 25 OH vitamin D assay for the LIAISON automated analyzer | April 2015 to April 2018 |