The Comparison of Changes of QTc, Tp-e Interval, and Tp-e/QT Ratio, Tp-e/QTc Ratio on the ECG During Living Donor Liver Transplantation Under Desflurane and Total Intravenous Anesthesia -Randomized Controlled Trial

Study Overview
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Brief Summary
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Prolonged corrected QT interval (QTc) has been observed in about half of patients with liver cirrhosis. Marked prolongation of QTc (ie, 500 msec) has been considered to be a risk factor for fatal ventricular arrhythmia, such as torsade de pointes,7,8 which has been reported in liver transplantation (LT) surgery. In a previous study, prolonged QTc interval ( 500 msec) was frequently observed throughout the procedure of LT, even among patients with baseline QTc 440 msec. Therefore, it is important to optimize electrolyte balance and hemodynamic status to reduce greater risk of perioperative arrhythmias. The investigators hypothesized that the change of QTc interval might be differ according to method of general anesthesia (inhalation agent vs. intravenous agent).

Official Title
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The Comparison of Changes of QTc, Tp-e Interval, and Tp-e/QT Ratio, Tp-e/QTc Ratio on the ECG During Living Donor Liver Transplantation Under Desflurane and Total Intravenous Anesthesia -Randomized Controlled Trial

Conditions
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Liver Cirrhosis(Who Will Undergo Planed Liver Transplantation)

Intervention / Treatment
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* Drug: inhalation (desflurane) group
* Drug: total intravenous (propofol) anesthesia


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients with liver cirrhosis who will undergo planned liver transplantation Exclusion Criteria: 1. emergent liver transplantation 2. unstable angina 3. recent MI(Myocardial Infarction) 4. uncontrolled hypertension (diastolic BP > 110mmHg) 5. implantable cardiac defibrillator 6. severe obesity (BMI>30kg/m2) 7. allergy to propofol

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Arm 1: inhalation anesthesia (desflurane) group Arm 2: total intravenous anesthesia (propofol) group
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: inhalation anesthesia (desflurane) group<br>Anesthesia is induced and maintained with desflurane and sufentanil | Drug: inhalation (desflurane) group<br>* Anesthesia is induced and maintained with desflurane and sufentanil<br>|
| Experimental: Total intravenous anesthesia (propofol) group<br>Anesthesia is induced and maintained with propofol and sufentanil | Drug: total intravenous (propofol) anesthesia<br>* Anesthesia is induced and maintained with propofol and sufentanil<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| QTc interval | The investigator will assess the QTc interval 3 minutes after the reperfusion during liver transplantation. | 3 minutes after liver reperfusion | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| QTc interval | The investigator will assess the QTc interval at the end of liver transplantation. | at the end of the surgery |