Efficacy of Various Treatments for Acute Acoustic Trauma.

Study Overview
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Brief Summary
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Acute acoustic trauma is a growing concern in the IDF. there is currently no accepted treatment. The present retrospective study is intended to evaluate the efficacy of different treatment modalities in the IDF between 01/01/2010 and 15/06/2020.

Official Title
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Efficacy of Various Treatments for Acute Acoustic Trauma in the Israeli Defense Force.

Conditions
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Acute Acoustic Trauma

Intervention / Treatment
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* Other: No intervention - retrospective study


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Subjects diagnosed with acute acoustic trauma. Hearing exam performed at least 24 hours after acute acoustic trauma. There was a reduction of at least 30dB in the 3,000-8,000 Hz frequency range in the first hearing exam performed. Exclusion Criteria: A known hearing impairment prior to acute acoustic trauma. Subjects lost from follow up. Another diagnosis is more likely than hearing loss due to acute acoustic trauma.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Steroids only - early<br>treatment was initiated within 7 days of acoustic trauma. | Other: No intervention - retrospective study<br>* No intervention - retrospective study<br>|
| Early combined steroid and hyperbaric oxygen therapy<br>treatment was initiated within 7 days of acoustic trauma. | Other: No intervention - retrospective study<br>* No intervention - retrospective study<br>|
| Delayed combined steroid and hyperbaric oxygen therapy<br>treatment was initiated after 7 days of acoustic trauma. | Other: No intervention - retrospective study<br>* No intervention - retrospective study<br>|
| Early sequential steroid followed by HBO therapy<br>treatment was initiated within 7 days of acoustic trauma. | Other: No intervention - retrospective study<br>* No intervention - retrospective study<br>|
| Delayed sequential steroid followed by HBO therapy<br>treatment was initiated after 7 days of acoustic trauma. | Other: No intervention - retrospective study<br>* No intervention - retrospective study<br>|
| Hyperbaric oxygen therapy only<br> | Other: No intervention - retrospective study<br>* No intervention - retrospective study<br>|
| No treatment<br> | Other: No intervention - retrospective study<br>* No intervention - retrospective study<br>|
| Steroid only - delayed<br>treatment was initiated after 7 days of acoustic trauma. | Other: No intervention - retrospective study<br>* No intervention - retrospective study<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hearing improvement | dB | until 1 year of acoustic trauma. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Tinnitus | Qualitative - subjective | until 1 year of acoustic trauma. | 
| Otoacoustic Emissions (OAE) | dB | until 1 year of acoustic trauma. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Hyperbaric Oxygen Therapy, Acute Acoustic Trauma, Steroids