Absolute Quantification in Bone Scintigraphy

Study Overview
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Brief Summary
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While absolute quantification in 18F-FDG PET (Positon Emission Tomography) is widely used in clinical routine, absolute quantification in SPECT (Single Photon Emission Computed Tomography) is under development and its clinical interest remains to be demonstrated. Recent studies carried out on bone scan recordings show the potential interest of quantification indexes such as SUV (Standard Uptake Value).

Detailed Description
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In oncology, bone scan studies have reported significantly higher SUV values for secondary bone lesions compared with benign osteoarticular lesions , and some have even defined an SUVmax threshold value that points to prostatic bone metastases.

Official Title
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Absolute Quantification in Bone Scintigraphy: Phantom Evaluation and Clinical Application in Patients Undergoing Follow-up for Vertebral Fractures.

Conditions
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Scintigraphy Quantification

Intervention / Treatment
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* Device: SPECT CT


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with recent vertebral fractures: who have had at least two SPECT/CT scan scans of the spine as part of a pre-vertebroplasty check-up, for which fracture dates were known. Exclusion Criteria: Minor person Person opposing the use of their data (Posters in waiting rooms explaining that the patient must object if they do not wish their data to be used)

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patient for SPECT/CT scan<br>Patients referred for SPECT/CT scan of the spine as part of a vertebroplasty workup and selected retrospectively. | Device: SPECT CT<br>* SPECT/CT scan of the spine as part of a vertebroplasty<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To validate the absolute bone scan quantification in a retrospectively selected patient population | Analysis of SUV variation on at least 2 bone scans: Variation of the SUV over time on scans of patients with spinal fractures | After 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To calibrate the tomographic images from the gamma camera | Calibrate the tomographic images from the gamma camera to obtain a volume activity in Bq/mLand densities | 1 day | 
| To evaluate the attenuation correction on phantoms of different density | SUV absolute quantitation index (SUVmax, SUVpeak, SUVmean). | 1 day | 
| To evaluate absolute quantification on phantoms | Evaluate absolute quantification on phantoms with objects of different volumes | 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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absolute quantification, Standard Uptake Value, bone scintigraphy