Prospective Research for Elderly (≥65 Years Old) Early Breast Cancer Patients

Study Overview
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Brief Summary
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The elderly patients over 65 years old with breast cancer have concomitant diseases, poor tolerance to conventional treatment, and the specific prognosis of breast cancer is relatively good. Previous studies on breast cancer have almost excluded elderly breast cancer patients, and conventional treatment schemes cannot meet the clinical diagnosis and treatment needs of elderly breast cancer patients. The establishment of a prognosis model for elderly breast cancer patients can provide personalized treatment programs. This is important for prolonging the survival time of patients and improving the quality of life. This project plans to observe the relationship between prognosis and pathological staging, molecular typing, and concomitant diseases of elderly breast cancer patients in combination with immune genes, and establish a prognosis model of elderly breast cancer and verify it. This project is expected to establish a new prognostic model for elderly breast cancer patients, accurately judge the prognosis of patients, and provide a new basis for hierarchical and personalized treatment of elderly breast cancer.

Official Title
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Prospective Research for Elderly (≥65 Years Old) Early Breast Cancer Patients

Conditions
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Breast Cancer Female

Intervention / Treatment
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* Procedure: operation
* Drug: Bisphosphonate


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: female patients with breast cancer ≥65 Years Old patients with breast cancer received operation in Peking Union Medical College Hospital treatment regimen was made in Peking Union Medical College Hospital Exclusion Criteria: patients with metastasis patietns with recurrence patients without pathological information

Ages Eligible for Study
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Minimum Age: 65 Years
Maximum Age: 100 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: operation|operation methods: breast-conserving surgery, mastectomy, axillary lymph node dissection, sentinal lymphnodes biopsy; chemotherapy regimens: AC, TC, AC-T/P, TCrb, TAC, capecitabine; ovarian protection:GnRHa; endocrine therapy: Aromatase inhibitor, TAM, Fulvestrant, CDK4/6 inhibitors; target therapy: trastuzumab，patuzumab, Pyrotinib.|
|Drug: Bisphosphonate|Bisphosphonate|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 5-y DFS | 5-years of disease free survival | 5 year | 
| 5-y BCSS | 5-year of breast cancer-specific survival | 5 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 5-y OS | 5-year overall survival | 5 year | 
| 10-y DFS | 10-years of disease free survival | 10 year | 
| 10-y BCSS | 10-year of breast cancer-specific survival | 10 year | 
| 10-y OS | 10-year overall survival | 10 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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≥65 Years Old, early breast cancer