A Case Series on Incidentally Detected Gallbladder Malignancy

Study Overview
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Brief Summary
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A retrospective analysis of data, using the Hospital records of all the patients who underwent cholecystectomy for benign conditions at Osmania General Hospital in a year (2019).

Detailed Description
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A retrospective analysis of hospital records of patients who underwent Cholecystectomy in a year duration (2019) for any benign condition, diagnosed and confirmed histopathologically as Gallbladder Malignancy. There are a total of one hundred and eighty patients who underwent cholecystectomy at our hospital (Osmania General Hospital) in 2019, out of which seven patients' histopathological diagnosis was gall bladder malignancy. We reviewed all the case's history, cross-checked the histopathological slides, and confirmed the diagnosis. To avoid the bias of covid-19 pandemic in surgical practice we confined the patient records to the pre-pandemic period of one-year duration (2019). A total of 180 patients underwent cholecystectomy for various benign conditions in one year, out of which seven patients confirmed histopathologically with Gallbladder malignancy. Total no of patients : 180 Diagnosed with malignancy : 7 percentage 3.8% Among these seven, three patients converted from laparoscopic to open procedure for difficulty with resection, two patients are posted for surgery considering empyema of gall bladder preoperatively, one patient in view of gall bladder perforation, and for two patients preoperative diagnosis was gall bladder polyp. Converted from Lap to Open: 3 Pre-op GB Polyp : 2 Perforated GB : 1 Empyema GB : 2 Only one patient is 40 years old and others are more than 50 years, and two of them are males. Total : 7 100% Males : 2 28.5% Females : 5 71.5% Out of a total of 180 patients who underwent cholecystectomy, 117 are females and 63 are males Total : 180 Males : 63 Females : 117 Out of 180, the age distribution is as follows Age. Percentage 20 - 29 0 30 - 39 0 40 - 49 0.005 >50. 99.99 It implies that the malignancy rate increases with an increase in the patient's age more than 50years and also with gender (Females > males).

Official Title
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A Case Series On Incidentally Detected Gallbladder Malignancy

Conditions
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Gallbladder Malignant Neoplasm

Intervention / Treatment
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* Procedure: Cholecystectomy, extended cholecystectomy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All patients who underwent cholecystectomy for benign conditions - Exclusion Criteria: All those who already diagnosed with gallbladder malignancy -

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients who underwent cholecystectomy for benign conditions<br>In those who underwent cholecystectomy for benign conditions, the histopathological analysis showed the malignancy. | Procedure: Cholecystectomy, extended cholecystectomy<br>* Cholecystectomy and histopathological evaluation<br>* Other names: Histopathological evaluation of the specimen;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diagnosed with Gallbladder malignancy | Those who underwent cholecystectomy for benign conditions are diagnosed with gallbladder malignancy | For one year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Gallbladder,, Polyp, Gallstones, Malignancy, Perforation