linjc16/ctgov huggingface dataset:
Impact of Non-invasive Brain Stimulation on Motor Recuperation

Study Overview
=================
Brief Summary
-----------------
tDCS (transcranial direct current stimulation) will be used in chronic stroke patients to improve a variety of functions with superior or inferior limb.

Detailed Description
-----------------
tDCS will be used in chronic stroke patients to improve a variety of functions such as motor functions with superior or inferior limb. tDCS will be applied in a placebo-controlled, double-blind, randomised fashion. Behavioural data will be collected before and after tDCS, as well as brain functional imaging data.

Official Title
-----------------
Impact of Non-invasive Brain Stimulation on Motor Recuperation

Conditions
-----------------
Stroke

Intervention / Treatment
-----------------
* Device: tDCS (ELDITH)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: stroke with at least slight deficit in superior or inferior limb Exclusion Criteria: epilepsy contraindication to tDCS and/or to fMRI presence of metal in the head inability to understand/complete behavioural tasks chronic intake of alcohol or recreative drugs major health condition presence of pacemaker pregnancy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Interventional Model Description: no change
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Real stimulation<br>real tDCS (well, that's the way it is I am not gonna change it) | Device: tDCS (ELDITH)<br>* tdcs (ELDITH, Neuroconn, Ilmenau, Germany) transcranial direct current stimulation<br>|
| Sham Comparator: Sham<br>sham tDCS | Device: tDCS (ELDITH)<br>* tdcs (ELDITH, Neuroconn, Ilmenau, Germany) transcranial direct current stimulation<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change in motor function before/after tDCS | Motor performance improvement with inferior or superior limb | Baseline (>6 months after stroke), immediately after intervention (30min of tDCS), 10-20-30-40-50-60 min after intervention; long-term after intervention : 1-2-3-4 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
stroke
Prediction of Postoperative Visual Acuity in Cataract Patients Using a Macular Optical Coherence Tomography-based Deep Learning Method

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to collect the macular OCT images and preoperative and postoperative visual acuity of cataract patients who had been operated in the eye center of the Second Affiliated Hospital of Zhejiang University Medical College, and to train a model that can relatively accurately predict the postoperative visual acuity of patients by deep learing.

Official Title
-----------------
Prediction of Postoperative Visual Acuity in Cataract Patients Using a Macular Optical Coherence Tomography-based Deep Learning Method

Conditions
-----------------
Data Collecting

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Senile cataract patients, with or without macular disease, the impact of cataract on vision has affected the daily life of patients. Exclusion Criteria: Glasses can obviously improve eyesight In addition to macular disease, combined with other eye diseases that seriously affect vision, resulting in no significant improvement in postoperative vision Complicated cataract surgery due to trauma and other reasons Combined with other eye diseases not suitable for intraocular lens implantation Patients with systemic diseases who cannot tolerate surgery

Ages Eligible for Study
-----------------
Minimum Age: 50 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Uncorrected distance visual acuity | The UCVA was measured by the same optometrist at each visit | 1 month postoperatively | 
| Best Corrected Visual Acuity | The BCVA was measured by the same optometrist at each visit | 1 month postoperatively | 
| Macular optical coherence tomography | Macular oct was measured by the same doctor at each visit | 1 month postoperatively | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
artificial intelligence, deep learning, cataract surgery, acuity vision, optical coherence tomography, macular
Nuclear Factor Kappa-B (NFKB1) Polymorphism and Organ Injury After Cardiac Surgery

Study Overview
=================
Brief Summary
-----------------
NFKB1 -94ins/del polymorphism has been reported to be associated with reduced promoter activity of NFKB1 and several clinical diseases, but the clinical results cannot always be replicated. Besides, mutate allele is associated with alleviated inflammation in ulcerative colitis and some tumors, but aggravated inflammation in ARDS. The clinical value of this polymorphism remains controversial. This study was performed to investigate the association of NFKB1 -94ins/delATTG polymorphism with lung and/or kidney injury after cardiac surgery with CPB.

Official Title
-----------------
Association of NFKB1 -94 Polymorphism With Lung and/or Kidney Injury After Cardiac Surgery With Cardiopulmonary Bypass

Conditions
-----------------
Single Nucleotide Polymorphism, Acute Lung Injury, Kidney Injury

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Chinese Han unrelated population undergoing elective cardiac surgery with CPB Exclusion Criteria: malignant tumor autoimmune disease, immunodeficiency or immunosuppressive therapy chronic renal disease (glomerular filtration rate < 60ml/(min•1.73m2)) or liver dysfunction (Child Pugh classification>A) COPD, tuberculosis or other chronic pulmonary diseases anemia with hemoglobin lower than 90mmHg bleeding disorders postoperative pericardial tamponade requiring re-operation postoperative low cardiac output syndrome or acute pulmonary edema after left cardiac failure.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| PLI<br>patients with postoperative lung injury | |
| without PLI<br>patients without postoperative lung injury | |
| PLI/PKI<br>patients with at least one organ injury of lung or kidney after surgery | |
| without PLI/PKI<br>patients without lung or kidney injury after surgery | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| lung injury and/or kidney injury after cardiac surgery with cardiopulmonary bypass |  | 24h after cardiac surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| circulating level of CRP, TNF-alpha, IL-10; APACHE Ⅱ score; duration of ICU stay and hospitalization; death in 28 days |  | one month after cardiac surgery |
Assessment of Potential Interactions Between Methamphetamine and Bupropion - 1

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to assess potential interactions between intravenous (IV) methamphetamine and oral bupropion.

Detailed Description
-----------------
This is a human laboratory clinical pharmacology study to assess potential interactions between IV methamphetamine challenge and treatment with oral sustained-release bupropion.

Official Title
-----------------
Double-Blind, Placebo-Controlled Assessment of Potential Interactions Between IV Methamphetamine and Oral Bupropion

Conditions
-----------------
Amphetamine-Related Disorders

Intervention / Treatment
-----------------
* Drug: Bupropion


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Please contact site director for more details. Exclusion Criteria: Please contact site director for more details.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Bupropion|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Psychological effects |  |  | 
| BP, HR |  |  |
Prognosis Factors Associated With Convulsive Status Epilepticus in Adults

Study Overview
=================
Brief Summary
-----------------
The aim of the study is to evaluate, prospectively, prognosis factors associated with convulsive status epilepticus (CSE) in adults hospitalized in intensive care units.

Detailed Description
-----------------
Status epilepticus is a neurologic and medical emergency associated with high mortality and morbidity rates. According to the operational definition Convulsive Status Epilepticus (CSE) is defined as a single clinical seizure lasting more than 10 min, or two or more repeated seizures over a period of more than 10 minutes without intervening recovery of consciousness. There are a few to date in literature reporting prognosis factors associated with this condition and, at this time, there are no published data considering an operational definition of CSE. In a retrospective study considering an operational definition we identified a seizure duration of 15 min associated with poor outcome (not yet published). The principal goal of this study is to evaluate factors associated with outcome in CSE, in particular seizure duration of more than 15 minutes. The secondary goals are to evaluate the epidemiology and management at every stage of CSE thus redefined.

Official Title
-----------------
Prognosis Factors Associated With Convulsive Status Epilepticus in Adults: A Multicenter Cohort Study

Conditions
-----------------
Status Epilepticus

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: More than 18 years old Convulsive status epilepticus according to operational definition as any seizure lasting for 10 minutes or longer, or two or more intermittent seizures lasting for greater than 10 minutes from which the patient did not regain consciousness. Beginning of seizure less than 12 hours before intensive care unit admission Convulsive status epilepticus occurring during intensive care unit stay Exclusion Criteria: Less than 18 years old Patients that seized up to 9 minutes Beginning of seizure more than 12 hours before intensive care unit admission

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
convulsive status epilepticus, outcome, prognosis factors, seizure duration, adult, electroencephalogram, intensive care unit
Prolonged Exposure (PE) Treatment for Post Traumatic Stress Disorder (PTSD) 20 Minutes Versus 40 Minutes

Study Overview
=================
Brief Summary
-----------------
Comparing the efficacy of 40 minutes PE treatment to 20 minutes of the same treatment

Conditions
-----------------
PTSD

Intervention / Treatment
-----------------
* Behavioral: Prolonged Exposure (PE) therapy
* Behavioral: Prolonged Exposure (PE) therapy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: PTSD Exclusion Criteria: Psychotic symptoms Dissociation Drug or Alcohol dependence

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: 1<br> | Behavioral: Prolonged Exposure (PE) therapy<br>* 20 minutes exposure<br>|
| Active Comparator: 2<br> | Behavioral: Prolonged Exposure (PE) therapy<br>* 40 minutes exposure<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| PSS-i |  | 15 weeks and 1-year follow-up | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Post traumatic stress disorder
A Study to Evaluate Rapid Throughput Screening for Human COVID-19 Infection

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to assess the ability of an artificial intelligence smartphone-enabled point of care ECG to detect COVID-19.

Official Title
-----------------
Rapid Throughput Screening for Human COVID-19 Infection: A ECG Study

Conditions
-----------------
Covid19

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adult males and females age 18 or greater. Undergoing COVID-19 testing by PCR. Willing and able to provide informed consent. Pregnant females (minimal risk study, no risk from ECG). Exclusion Criteria: - Unwilling or unable to provide informed consent.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 89 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| COVID 19 Detection | Determine the safety and feasibility of the POC AI-ECG's ability to detect active SARS-Cov-2 infection in humans. | One time screening within 4 hours of PCR test |
External Validation of the Apfel Risk Score and Koivuranta Score to Predict Postoperative Nausea and Vomiting in Patients With Liver Cancer

Study Overview
=================
Brief Summary
-----------------
Postoperative nausea and vomiting (PONV) is a common complication among surgical patients. The incidence ranging from 20% to 50% depends on different population studied. Clinical practice guidelines recommend routine PONV screening before surgery using the Apfel simplified risk score OR Koivuranta score. However, these two scores haven't been translated into Chinese version and tested for psychometric qualities. Therefore, this study aim to externally validate two PONV prediction models in the Chinese hospital setting for PONV assessment.

Official Title
-----------------
External Validation of Two Models to Predict Postoperative Nausea and Vomiting (PONV) in Patients With Liver Cancer in Chinese Hospital Setting

Conditions
-----------------
Postoperative Nausea and Vomiting, Hepatobiliary Surgery, Prediction Model

Intervention / Treatment
-----------------
* Other: no intervention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients receiving hepatobiliary surgery Exclusion Criteria: patients receiving chemothreapy；patients with cognitive disorders; patients unwilling to participate.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with low risk of PONV<br> | |
| Patients with high risk of PONV<br> | Other: no intervention<br>* this is an abservational study and no intervention will be involved<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| postoperative nausea and vomiting | Postoperative nausea will be assessed at 24 hours after surgery on an 11-point numeric scale (0 -10) by a trained nurse. Patients will be asked to respond to the question, Have you felt nauseated since your discharge from the postanesthetic care unit and if so, what would be the average level of nausea you have felt until now on a 0 to 10 scale?. Patients will be considered nauseated if postoperative nausea is reported to be greater than zero on the 11-point scale with the question. For the same intervals the number of episodes of postoperative vomiting will be recorded. Again, patients will be considered to have vomited if postoperative vomiting occurs at least once within 24 hours. Patients who have either postoperative nausea or postoperative vomiting in 24h will be considered to have PONV. | 24 hours after surgery | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Postoperative Nausea and Vomiting, hepatobiliary surgery, assessment tool
Early Versus Delayed Oral Liquids and Soft Food After Elective Ceasarean Section

Study Overview
=================
Brief Summary
-----------------
To compare the safety of early versus delayed oral feeding after uncomplicated cesarean section under spinal anesthesia

Detailed Description
-----------------
Cesarean section is one of most common surgical procedures saving both for mother and newborn when medically indicated .traditionally patients are not given fluids or food afer abdominal surgery until bowel function return as evidenced by bowel sounds passage of flatus or stool or feeling of hunger the rationale of this practice is to prevent postoperative nausea , vomiting, distension and other complications

Official Title
-----------------
Early Versus Delayed Oral Liquids and Soft Food After Elective Ceasarean Section

Conditions
-----------------
Prevent Postopertive Nausea and Vomiting

Intervention / Treatment
-----------------
* Other: Oral liquids and soft food 2 hours postoperative


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: previous 1,2,3 cs Uncomplicated elective cs Singletone pregnancy Spinal anesthesia Exclusion Criteria: women with medical disorder HTN, DM History of bowel surgery or intraoprative complication Contraindication to spinal anesthesia

Ages Eligible for Study
-----------------
Minimum Age: 17 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
Female

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group A<br>Early feeding group | Other: Oral liquids and soft food 2 hours postoperative<br>* Early versus delayed oral liquid feeding after ceasarean section<br>|
| Group B<br>Delayed feeding group | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time of passage of flatus |  | 6 hrs |
Study for a Rational Management of Appendicitis in Children

Study Overview
=================
Brief Summary
-----------------
Despite the fact that appendicitis is one of the most frequent surgical pathology in children, its clinical management is still debated. Previous reports have shown rate of appendectomy in children without appendicitis up to 30 %. Morbidity, due to infectious complications or intestinal obstruction, is often between 5 and 10 % of published cases, and increase medical and social costs. Evidence-based medicine concept could therefore be worthwhile in that context, in order to promote rational diagnosis and treatment of that frequent medical condition.An algorithm describing management of children with suspicion of appendicitis was established, based on recent published data, in order to reduce delay between first clinical signs and confirmation of the diagnosis, and to define therapeutic indication such as conservative management and interval appendectomy or patient requiring laparoscopic approach. The main objective of the study is to decrease morbidity and unnecessary appendectomy rates, and secondly to decrease costs, by the use of that algorithm.

Official Title
-----------------
Multicenter Prospective Study for a Rational Management of Appendicitis in Children

Conditions
-----------------
Appendicitis

Intervention / Treatment
-----------------
* Procedure: appendectomy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: male and female children, between 4 and 15 years-old, with more than 37,5°C of body temperature during the 3 days before hospital admission, and with abdominal pain located in right or median lower quadrant Exclusion Criteria: children coming from another hospital, children with septic choc, children with co-morbidity in interaction with algorithm (antibiotics allergy, mellitus diabetes, haemostasis disturbance, …)

Ages Eligible for Study
-----------------
Minimum Age: 4 Years
Maximum Age: 15 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: appendectomy|Randomisation will apply to the 8 participating centers as follow: During a first survey period of 6 month, the algorithm is not applied; The six following months, 4 randomised centers applied the algorithm, the others being still survey; The six last month, all centers will apply the algorithm|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Appendicitis, children