Correlation Between Duration of Fasting and Response to Fluid Replenishment, Evaluated With Repeated Measures of VTI.

Study Overview
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Brief Summary
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The investigators will study the correlation between the lenght of the fasting before surgery and the need to replenish with intra-venous fluids in children, evaluated with 3 measures of the aortic Integral Time Velocity with transthoracic echocardiography.

Official Title
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Corrélation Entre la Longueur de jeûne et la réponse au Remplissage Vasculaire évaluée Par Des Mesures répétées de l'ITV.

Conditions
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Fluid and Electrolyte Imbalance, Fluid Therapy

Intervention / Treatment
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* Other: Plasmalyte A Viaflo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Children aged between 3 and 6 years with a normal ponderal evolution. Children with good general status (ASA 1) Children whose parents have given the informed authorization to do the study. Children seen in the consultation of anesthesiology. Children programed to have ambulatory surgery (Amygdalectomy, dental care, dental extraction). Exclusion Criteria: Children with more than 6 years of age. Children whose parents didn't agree with the study. Children enrolled in another study on the 3 months before. Children with hearth or lung conditions.

Ages Eligible for Study
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Minimum Age: 2 Years
Maximum Age: 6 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Patient<br>One-arm study, where all patients are given the same standard fluidotherapy and anesthetic conditions to compare measures of Aortic VTI before and after the IV fluid. | Other: Plasmalyte A Viaflo<br>* Fluid therapy to be given according to the principle of 4-2-1 (4 ml of crystalloid fluid for each of the first 10 kg of weight (0-10 kg), 2 ml of crystalloid fluid for each of the second 10 kg of weight (11-20 kg) and 1 ml of crystalloid fluid for each kg of weight over 20.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Aortic VTI change | Transthoracic echocardiography measures of the Time-Speed Interval in the aortic valve before fluid therapy (baseline) and after fluid therapy (20 ml/kg in 15 minutes). | From baseline analysis (t=5 min after anesthesia induction), to the end of fluid therapy (t=20 min). | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood pressure change | Analysis of the variation of Mean Arterial Blood pressure with fluid therapy | From baseline analysis (t=5 min after anesthesia induction), to the end of fluid therapy (t=20 min). | 
| Legs-up maneuver | Analysis of the variation of Mean Arterial Blood pressure with the legs up maneuver | From baseline analysis (t=5 min after anesthesia induction), to the end of legs-up maneuver (t = +/- 10 min). | 
| Post-operative nausea and vomiting | Comparisson of the incidence of post-operative nausea and vomiting in the fluid respondeurs group vs non respondeurs. | From arrival at PACU (end of surgery) until discharge from PACU (tipically after 1 to 2 hours after the arrival to the PACU) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Rehydration Solutions