Primary Headaches and Irritable Bowel Syndrome.

Study Overview
=================
Brief Summary
-----------------
To assess the relationship between primary headaches and irritable bowel syndrome

Detailed Description
-----------------
The association between primary headaches and functional gastrointestinal disorders has been confirmed by many clinical observations. In most patients during the attacks of headache, apart from various neurological and vascular symptoms, gastrointestinal disturbances occur . Functional gastrointestinal disorders, such as irritable bowel syndrome (IBS), are reported in primary headache patients in periods between the attacks as well. On the other hand 23-53% of IBS patients have frequent headaches. Migraine typically presents relapsing episodes of symptoms including headache, nausea, vomiting, sensory hypersensitivity and mood changes that last for hours to days . Similar to migraine, IBS is characterized by recurrent abdominal pain or discomfort with altered gastrointestinal motility and visceral hypersensitivity that returns to normal between attacks . Both pain disorders lack detectable organic causes . An emerging model of the brain-gut axis was proposed to explain migraine and IBS as a result of a genetically sensitive nervous system that develops hyperexcitability over time as a response to multiple environmental and immunological factors. Cluster headache (CH) characterized by its distinctive circadian and circannual periodicity, implicating the role of the hypothalamus in its underlying pathophysiology. CH and IBS are featuring recurrent attacks of pain that possess relationships with circadian rhythms and potentially hypothalamic derangements. Tension headache that's associated with pain in head described as feeling like a tight band around head, also show many similarities with IBS such causes for both are unknown, and some studies suggest a possible link that could shed light on shared genetics of both condition .

Official Title
-----------------
Association Between Primary Headaches and Irritable Bowel Syndrome.

Conditions
-----------------
Primary Headache Disorder

Intervention / Treatment
-----------------
* Other: a questionnaire based on Rome IV Diagnostic criteria of IBS


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age more than 18. both sex. history suggestive of any type of primary headaches. accept to participate in the study. Exclusion Criteria: Intake of medications that can aggravate Headache or IBS. Presence of neurological disease other than primary headaches. Presence of gastrointestinal disease other than IBS.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: a questionnaire based on Rome IV Diagnostic criteria of IBS|The Rome IV criteria for the diagnosis of IBS require that patients have had recurrent abdominal pain on average at least 1 day per week during the previous 3 months that is associated with two or more of the following Related to defecation (may be increased or unchanged by defecation) Associated with a change in stool frequency Associated with a change in stool form or appearance The Rome IV criteria (May 2016) only require abdominal pain in defining this condition; discomfort is no longer a requirement owing to its nonspecificity, and the recurrent abdominal pain. [2] Supporting symptoms include the following:Altered stool frequency Altered stool form Altered stool passage (straining and/or urgency) Mucorrhea Abdominal bloating or subjective distention.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Association between primary headaches and irritable bowel syndrome | To Detect the prevalence of IBS among patients with primary headaches | Basline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Subtypes of primary headachecs and IBS | Detect the intimate correlation between each type of primary headaches and IBS | Basline |