Rotating Frame Relaxation Imaging in Patients With Multiple Sclerosis

Study Overview
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Brief Summary
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The aim of this study is to develop novel magnetic resonance imaging (MRI) protocols suitable for patients with multiple sclerosis using advanced MRI such as rotating frame relaxation imaging. In addition, the investigators want to study the correlation between advanced MRI parameters and clinical disease progression.

Official Title
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Rotating Frame Relaxation Imaging in Patients With Multiple Sclerosis

Conditions
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Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Chronic Progressive

Intervention / Treatment
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* Other: Brain MRI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: The diagnosis of relapsing remitting MS made according to the Poser, McDonald's or revised McDonald's criteria (Group I) before participating in the study Initial MS diagnosis of relapsing remitting form of the disease according to the criteria as mentioned above, and conversion into the secondary progressive phase of the disease as evaluated by the referring neurologist according to the clinical evaluation and confirmed by the study physician (Group II). Mental status: Patients must be able to understand the meaning of the study Informed consent: The patient must sign the appropriate Ethical Committee (EC) approved informed consent documents in the presence of the designated staff Exclusion Criteria: Any other autoimmune disease than MS requiring immunomodulatory or immunosuppressive medication High-dose corticosteroid treatment within 30 days before participating in the study Prior medical history: Patient must have no history of serious cardiovascular, liver or kidney disease Any psychiatric condition that compromises the subject's ability to participate in the study Infections: Patient must not have an uncontrolled serious infection No contraindications for MRI (cardiac pacemaker, intracranial clips etc)

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Multiple Sclerosis<br>Brain MRI using advanced MR techniques | Other: Brain MRI<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| MR relaxation values 0 | Aim is to measure different quantitative MR relaxation values (e.g. Traff, T1rho) in different brain areas of patients with MS at baseline | Baseline | 
| MR relaxation values 1 | Aim is to measure different quantitative MR relaxation values (e.g. Traff, T1rho) in different brain areas of patients with MS after one year follow-up | One year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| MR relaxation values and clinical markers 0 | Aim is to study the correlation between MR relaxation values and clinical markers of MS at baseline | Baseline | 
| MR relaxation values and clinical markers 1 | Aim is to study the correlation between MR relaxation values and clinical markers of MS after one year follow up | One year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Multiple Sclerosis, MRI, rotating frame