Efficacy Testing of Collagen Drink on Skin Beauty and Sleep Aid

Study Overview
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Brief Summary
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To assess Collagen Drink on skin condition and sleep quality improvement

Official Title
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Efficacy Testing of Collagen Drink on Skin Beauty and Sleep Aid

Conditions
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Skin Condition, Sleep Disturbance

Intervention / Treatment
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* Dietary Supplement: Placebo drink
* Dietary Supplement: Collagen Juice Drink


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy adults aged above 20 years old Exclusion Criteria: Subject who is not willing to participate in this study. Patients with diseases of the skin, liver, kidney. Subjects who have known cosmetic, drug or food allergies, difficulty in digestive tract absorption or disorder. Female who is pregnant or nursing Constant drug use Received facial laser therapy, chemical peeling or UV overexposure (>3 hours everyday) in the past 4 weeks. Students taught by the PI

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Placebo drink<br> | Dietary Supplement: Placebo drink<br>* Blank<br>|
| Experimental: Collagen drink<br> | Dietary Supplement: Collagen Juice Drink<br>* Testing product<br>* Other names: LISAVEI® Collagen Juice Drink;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The change of skin wrinkles | VISIA Complexion Analysis System was utilized to measure skin wrinkles. Units: arbitrary units | Change from Baseline skin wrinkles at 8 weeks | 
| The change of skin texture | VISIA Complexion Analysis System was utilized to measure skin texture. Units: arbitrary units | Change from Baseline skin texture at 8 weeks | 
| The change of skin collagen density | DermaLab® Series SkinLab Combo was utilized to measure skin pores. Units: arbitrary units | Change from Baseline skin collagen density at 8 weeks | 
| The change of skin elasticity | Cutometer® MPA580 was utilized to measure skin elasticity. Units: arbitrary units | Change from Baseline skin elasticity at 8 weeks | 
| The change of skin L* value | Chroma Meter MM500 was utilized to measure skin L* value. Units: arbitrary units, 0-100 | Change from Baseline L* value at 8 weeks | 
| The change of sleep quality | Self-assessment questionnaire was utilized to survey sleep quality. | Change from Baseline sleep quality at 8 weeks | 
| The change of AGEs of blood | Venous blood was sampled to measure AGEs | Change from Baseline AGEs at 8 weeks | 
| The change of TIMP-1 of blood | Venous blood was sampled to measure TIMP-1 | Change from Baseline TIMP-1 at 8 weeks | 
| The change of desmosine of blood | Venous blood was sampled to measure desmosine | Change from Baseline desmosine at 8 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The change of skin melanin index | Soft Plus was utilized to measure skin melanin index. Units: arbitrary units | Change from Baseline skin melanin index at 8 weeks | 
| The change of skin pores | VISIA Complexion Analysis System was utilized to measure skin pores. Units: arbitrary units | Change from Baseline skin pores at 8 weeks | 
| The change of skin a* value | Chroma Meter MM500 was utilized to measure skin a* value. Units: arbitrary units | Change from Baseline skin a* value at 8 weeks | 
| The change of skin hydration | Corneometer® CM825 was utilized to measure skin hydration. Units: arbitrary Corneometer® units 0-120 | Change from Baseline skin hydration at 8 weeks | 
| The change of transepidermal water loss | Tewameter® TM300 was utilized to measure skin hydration. Units: g/hm² | Change from Baseline transepidermal water loss at 8 weeks |