Effectiveness of Supportive Psychotherapy Through Internet-Based Teleconsultation on Psychological and Somatic Symptoms, Neutrophil-Lymphocyte Ratio, and Heart Rate Variability in Post Covid-19 Syndrome Patients

Study Overview
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Brief Summary
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The goal of this clinical trial is to learn about the effectiveness of supportive psychotherapy in post covid-19 syndrome patients. The main questions it aims to answer are: What is the effect of supportive psychotherapy on psychological and somatic symptoms in post covid-19 syndrome patients? What is the effect of supportive psychotherapy on the neutrophil lymphocyte ratio in post covid-19 syndrome patients? What is the effect of supportive psychotherapy on heart rate variability in post covid-19 syndrome patients? Participants will be given supportive psychotherapy in the form of an online group for 3 times a week with a duration of psychotherapy ranging from 1 - 2 hours per session. Researchers will compare the supportive psychotherapy group to education group as control. The control group will be given education about Post Covid-19 syndrome in the form of an online group for 3 times a week with a duration of around 1 - 2 hours per session.

Official Title
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Effectiveness of Supportive Psychotherapy Through Internet-Based Teleconsultation on Psychological and Somatic Symptoms, Neutrophil-Lymphocyte Ratio, and Heart Rate Variability in Post Covid-19 Syndrome Patients

Conditions
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Post-COVID-19 Syndrome

Intervention / Treatment
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* Behavioral: Supportive Psychotherapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 18 years or over Patients confirmed positive for SARS CoV-2 by molecular testing (SARS CoV-2 RT-PCR, naso-oropharyngeal swab) at least 3 months before recruitment, with symptoms and effects lasting for at least 2 months and not explained by alternative diagnoses other Patients with or without comorbidities: diabetes mellitus, hypertension, tuberculosis, asthma, chronic obstructive pulmonary disease, chronic kidney disease, heart disease, chronic liver disease, malignancy, nervous system disease, patients with vulnerability, patients with disabilities. Patients can communicate and are willing to be interviewed, fill out questionnaires and psychotherapy. The patient is willing to fill out and sign an informed 1 sheet of consent to participate in the study Exclusion Criteria: Psychosis Can not access internet for psychotherapy Not willing to take part in the research

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Supportive Psychotherapy<br>supportive psychotherapy will be given in the form of an online group for 3 times a week with a duration of psychotherapy ranging from 1 - 2 hours per session | Behavioral: Supportive Psychotherapy<br>* Supportive psychotherapy is a treatment that uses direct measures to ameliorate symptoms and to maintain, restore or improve self-esteem, ego function, and adaptive skills<br>|
| Active Comparator: Education<br>education about post covid-19 syndrome will be given in the form of an online group for 3 times a week with a duration about 1 - 2 hours per session | Behavioral: Supportive Psychotherapy<br>* Supportive psychotherapy is a treatment that uses direct measures to ameliorate symptoms and to maintain, restore or improve self-esteem, ego function, and adaptive skills<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pyschological and somatic symptoms | Measured with SCL-90 questionnaire. Minimum score is 0, maximum score is 360. Higher scores mean worse outcome | Change from baseline SCL-90 questionnaire at 1 week | 
| Neutrophil Lymphocyte Ratio (NLR) | Measured by calculating the value of the ratio of neutrophils and lymphocytes based on blood sampling | Change from baseline NLR at 1 week | 
| Heart Rate Variability | Measured by assessing SDNN by using Photoplethysmograph SA-3000P | Change from baseline SDNN at 1 week |