Comparison of Outcomes Between Parenteral and Enteral Nutrition

Study Overview
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Brief Summary
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Short-term outcomes of parenteral and enteral nutrition for patients unable to eat normally were compared and analyzed.

Detailed Description
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Data were acquired from patients selected from a national inpatient database covering 1,057 hospitals in Japan. Participants had received artificial nutrition between April 2012 and March 2013, were 20 years or older, and did not have cancer. Participants were grouped into two groups: those receiving parenteral nutrition and those receiving enteral nutrition. The investigators performed one-to-one propensity-score matching between the groups. The primary outcome measurements were mortality rates at 30 and 90 days after the start of the procedure. The secondary outcomes were post-procedural complications, pneumonia, and sepsis. The investigators analyzed survival length of stay after the procedure using a Cox proportional hazards model.

Official Title
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Comparison of Short-term Mortality and Morbidity Between Parenteral and Enteral Nutrition for Adults Without Cancer: a Propensity-matched Analysis Using a National Inpatient Database

Conditions
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Deglutition Disorders

Intervention / Treatment
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* Device: Parenteral nutrition
* Device: Enteral nutrition


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: investigators selected participants aged 20 years or older who had undergone either parenteral nutrition by central venous port insertion or enteral nutrition by percutaneous endoscopic gastrostomy, percutaneous transesophageal gastrotubing, or ileostomy between April 1, 2012, and March 31, 2013. Patients who received both gastrostomy and central venous port insertion were assigned to the gastrostomy group. Exclusion Criteria: investigators excluded participants who had been diagnosed with cancer.

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Parenteral nutrition<br>investigators selected participants aged 20 years or older who had undergoneparenteral nutrition by central venous port insertion between April 1, 2012, and March 31, 2013. | Device: Parenteral nutrition<br>* Participants are retrospectively selected with propensity score matching<br>|
| Enteral nutrition<br>investigators selected participants aged 20 years or older who had undergone enteral nutrition by percutaneous endoscopic gastrostomy, percutaneous transesophageal gastrotubing, or ileostomy between April 1, 2012, and March 31, 2013. | Device: Enteral nutrition<br>* Participants are retrospectively selected with propensity score matching<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality Calculated From Outcome Section From DPC Database at 90 Days |  | 90 days after the start of the procedure | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Post-procedural Pneumonia |  | the incidence of post-procedural pneumonia occurring during hospitalization. Participants will be followed for the duration of hospital stay, an expected median of 3 weeks after procedure. | 
| Post-procedural Sepsis |  | the incidence of post-procedural sepsis occurring during hospitalization. Participants will be followed for the duration of hospital stay, an expected median of 3 weeks after procedure. | 
| Re-admission 30 Days |  | re-admission within 30 days of discharge. | 
| Mortality Calculated From Outcome Section From DPC Database at 14 Days |  | 14 days after the start of the procedure | 
| Mortality Calculated From Outcome Section From DPC Database at 30 Days |  | 30 days after the start of the procedure | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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parenteral nutrition, enteral nutrition