Treatment of Periodontal Intrabony Defects Using Autologous Platelet Rich Fibrin vs Titanium Platelet Rich Fibrin

Study Overview
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Brief Summary
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Background: To compare the effectiveness of open flap debridement (OFD) alone and OFD along with either Autologous Platelet Rich Fibrin (PRF) or Titanium Platelet Rich Fibrin (TPRF) in the treatment of intrabony defects (IBDs). Materials and methods: Study was conducted on subjects reporting to the Department of Periodontics, The Oxford Dental College and Hospital, Bangalore. 38 subjects with 90 periodontal IBDs of moderate to severe periodontitis were selected and assigned to OFD alone (group I) or OFD with Autologous PRF (group II) or OFD with TPRF (group III). In each subject, a minimum number of two sextants were present with probing pocket depths (PPD) ≥5mm in at least three teeth.

Official Title
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Treatment of Periodontal Intrabony Defects Using Autologous Platelet Rich Fibrin and Titanium Platelet Rich Fibrin: A Randomized Clinical Comparative Study

Conditions
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Periodontitis

Intervention / Treatment
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* Procedure: Open flap debridement (OFD)
* Procedure: OFD with Platelet rich fibrin (PRF)
* Procedure: OFD with Titanium Platelet rich fibrin (TPRF)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: presence of minimum 20 permanent teeth age group 20-55 years radiographic evidence of periodontal IBDs probing pocket depth (PPD) >5mm in minimum two sextants in at least three teeth clinical attachment (CA) loss of ≥ 3mm. Exclusion Criteria: Systemically compromised subjects those on medications (corticosteroids/ bisphosphonate therapy) that may interfere with wound healing grade III tooth mobility smokers and alcoholic subjects pregnant and lactating mothers subjects who underwent periodontal treatment within a period of 1 year.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 55 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Group 1<br>SRP with Open flap debridement (OFD) alone for treating periodontal pocket | Procedure: Open flap debridement (OFD)<br>* Oral prophylaxis followed by Open flap debridement (OFD)<br>|
| Active Comparator: Group 2<br>SRP with Open flap debridement (OFD) with Platelet rich fibrin (PRF) placement into bone defect | Procedure: OFD with Platelet rich fibrin (PRF)<br>* Oral prophylaxis followed by Open flap debridement (OFD) with Platelet rich fibrin (PRF) placement into the bone defect<br>|
| Active Comparator: Group 3<br>SRP with Open flap debridement (OFD) with Titanium Platelet rich fibrin (TPRF) placement into bone defect | Procedure: OFD with Titanium Platelet rich fibrin (TPRF)<br>* Oral prophylaxis followed by Open flap debridement (OFD) with Titanium Platelet rich fibrin (TPRF) placement into the bone defect<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| defect depth reduction (DDR) |  | Change from baseline to 9 months | 
| change in clinical attachment level (CAL) |  | Change from baseline to 9 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change in probing pocket depths (PPD) |  | Change from baseline to 9 months | 
| change in plaque index (PI) |  | Change from baseline to 9 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Periodontal regeneration, Growth factors