The Effect of Sleep Loss on Emotion Regulation

Study Overview
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Brief Summary
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The study is designed to investigate the impact of three nights of sleep restricted to 4 hours per night, on the processing and regulation of emotional information compared to Insomnia Disorder and control. The investigators will address and attempt to answer two questions. (i) How do three nights of reduced sleep or a diagnosis of Insomnia Disorder affect the processing and regulation of emotional information compared to typical, undisturbed sleep? (ii) What overlapping and distinct neural mechanisms are engaged and associated with behavioral effects when attempting to process and regulate emotions in a sleep restricted state or with a clinical diagnosis of Insomnia Disorder? This study will investigate sleep's role in emotion processing and regulation. The findings will help further understanding of the role of sleep in healthy emotional functioning.

Detailed Description
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Goal 1: How does sleep loss and clinical sleep disruption (i.e. Insomnia Disorder) impact emotion perception and emotion regulation? The investigators are interested in how chronic loss of sleep, either through artificially restricting sleep or clinically related sleep disturbance, impairs our ability to properly perceive and regulate our responses to emotional information using various emotion regulation strategies. There has been research on the effect of sleep loss on broad areas of cognition, such as attention, working memory, and reasoning ability, but the impact of long-term sleep loss on emotional processing and regulation remains largely unexplored. The investigators aim to characterize how sleep loss via experimentally reduced sleep in healthy control participants or clinical sleep disturbance in patients with Insomnia Disorder, affects the ability to accurately perceive emotion. Investigators will also investigate how it alters the intensity with which emotions are perceived, and the effect that these changes have on the ability to regulate emotional responses to these stimuli compared to healthy control participants that are allowed undisturbed sleep. Goal 2: How are changes in subjective emotional responses reflected in the neural signal and psychophysiological measures? The investigators will utilize fMRI and measures of autonomic reactivity (heart rate and skin conductance) to characterize the neural and psychophysiological responses that are associated with behavioral changes following sleep restriction or in patients with Insomnia disorder compared to healthy sleep control participants.

Official Title
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The Impact of Insufficient Sleep and Insomnia Disorder on Behavioral and Neural Markers of Emotion Regulation

Conditions
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Sleep, Insomnia, Sleep Deprivation

Intervention / Treatment
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* Behavioral: Sleep Restriction


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: willing and able to follow the protocol willing and able to meet inclusion criteria for fMRI scanning willing to refrain from alcohol and recreational drugs for the duration of the protocol normal or corrected to normal vision is required Exclusion Criteria: left-handedness or ambidexterity the use of any drugs that could affect either sleep or cognitive functioning (e.g., prescription sleeping pills or antidepressants)

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Independent Groups Comparison
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Normal Sleep<br>Normal Sleep - Healthy participants are permitted normal nights of polysomnography or actigraphy recorded sleep before participating in an emotion regulation task during functional Magnetic Resonance Imaging (fMRI) scanning | |
| Active Comparator: Sleep Restriction<br>Healthy Participants are sleep restricted to 4 hours of sleep for 3 consecutive days before participating in an emotion regulation task during functional Magnetic Resonance Imaging (fMRI) scanning | Behavioral: Sleep Restriction<br>* Three nights of sleep restricted to 4 hours per night.<br>|
| No Intervention: Patients with Insomnia Disorder<br>Patients with Insomnia Disorder will also be recruited and will be permitted normal nights of polysomnography or actigraphy recorded sleep before participating in an emotion regulation task during functional Magnetic Resonance Imaging (fMRI) scanning | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Baseline Emotional Regulation Task with Strategy | Baseline behavioral ratings to emotional stimuli with emotion regulation strategies | Day 1 | 
| Baseline Emotional Regulation Task without Strategy | Baseline behavioral ratings to emotional stimuli without emotion regulation strategies | Day 1 | 
| Reassessment of the Emotional Regulation Task with Strategy Baseline behavioral ratings to emotional stimuli with or without emotion regulation strategies | Behavioral ratings to emotional stimuli with emotion regulation strategies following normal sleep or sleep restriction | one test in a 3-6 day window | 
| Reassessment of the Emotional Regulation Task without Strategy Baseline behavioral ratings to emotional stimuli with or without emotion regulation strategies | Behavioral ratings to emotional stimuli without emotion regulation strategies following normal sleep or sleep restriction | one test in a 3-6 day window | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Functional Magnetic Resonance Imaging (fMRI) | fMRI measured neural reactivity (blood oxygen-level dependent signal) | one test in a 3-6 day window | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Emotion, Sleep Restriction, Insomnia Disorder, Sleep, Emotion Regulation, functional Magnetic Resonance Imaging (fMRI)