Nutritional Status and Prognosis in Heart Failure.

Study Overview
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Brief Summary
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The purpose of this study is to determine whether nutritional status or body composition influences the prognosis of heart failure patients.

Detailed Description
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Despite obesity is a cardiovascular risk factor, numerous studies have identified a better prognosis in overweight and obese heart failure (HF) patients. This paradox has been named the obesity paradox. However, this paradox has been criticized because the parameter used to classify obesity, the body mass index (BMI), has several limitations. Obesity is defined as an abnormal or excessive fat accumulation, and BMI does not always reflect real body fat. What is more, patients with HF can have their body composition altered with hyperhydration or undernourishment. A pilot study proved that BMI does not indicate true nutritional status in HF. Thus, a further assessment of body composition of HF patients, analyzing the nutritional status rather BMI, could shed light on the obesity paradox. The aim of this study was to assess the nutritional status of a cohort of HF patients, its correspondence with BMI, and its significance in terms of survival.

Official Title
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Nutrition Status and Body Composition in Ambulatory Patients With Heart Failure and Its Prognostic Significance (PLiegues en Insuficiencia Cardiaca-PLICA).

Conditions
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Heart Failure

Intervention / Treatment
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* Other: No intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Clinical diagnosis of heart failure according to the European Guidelines of Heart Failure. Depressed LVEF (< 45%) or ≥ 1 hospital admission due to HF decompensation Outpatients > 18 years of age, male or female, capable of giving an informed consent. Exclusion Criteria: Severe co-morbidity associated with a reduction in life expectancy of less than 1 year. Myopathy or other diseases that could cause significant sarcopenia beyond HF. Non-controlled hyperthyroidism

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Heart failure<br>Heart failure patients attending a HF clinic with depressed LVEF (< 45%) or ≥ 1 hospital admission due to HF decompensation. | Other: No intervention<br>* No intervention<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| All cause mortality |  | 3 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cardiac mortality and non-cardiac mortality |  | 3 years | 
| Heart failure hospitalizations |  | 3 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Heart Failure, Malnutrition, Undernutrition, Nutrition Assessment, Nutritional Assessment, Nutritional Index, Prognostic Nutritional Index, Prognostic Nutritional Index (PNI), Nutritional Status, Prognosis, Cardiovascular Diseases, Body Composition, Body Weights and Measures