linjc16/ctgov huggingface dataset:
Premolar Extractions for Obstructive Sleep Apnea in Children With Overjet

Study Overview
=================
Brief Summary
-----------------
This research aims to provide pediatric patients with polysomnography (a sleep study) before and after orthodontic treatment to determine if the extraction of upper premolars for treating excessive overjet results in an increase of the AHI (Apnea Hypopnea Index) compared to similar patients treated without upper premolar extractions.

Official Title
-----------------
The Effect of Upper Premolars Extraction on Obstructive Sleep Apnea in Growing Children With Prominent Upper Front Teeth

Conditions
-----------------
Obstructive Sleep Apnea, Malocclusion

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 10-15 years old registered orthodontic patients able to undergo routine orthodontic care and are registered to obtain an orthodontic appliance in the future. do not have a high care need no known hypercapnia or hypoventilation no known allergies or nose blockages diagnosed as Class II Division I (=6mm of overjet) and bilateral Class II half cusp or unilateral Class II full cusp. Exclusion Criteria: known hypercapnia or hypoventilation patients with hypertrophic tonsils and adenoids patients with allergies or nose blockages that interfere with breathing patients who are not registered as orthodontic patients at research sites deemed acceptable to undergo routine orthodontic care

Ages Eligible for Study
-----------------
Minimum Age: 10 Years
Maximum Age: 15 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| With Extractions<br>Patients in this group will undergo dental extractions. | |
| Without Extractions<br>Patients in this group will not undergo dental extractions. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Risk of Obstructive Sleep Apnea | Percentage of participants who develop obstructive sleep apnea following orthodontic treatment. | 30 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
orthodontic, braces, extraction, teeth, overjet
14-Day Cumulative Irritation Patch Test in Subjects With Normal Skin - Chameleon

Study Overview
=================
Brief Summary
-----------------
to determine the ability of the test article to cause irritation to the skin of humans under controlled patch test conditions

Conditions
-----------------
Dermal Irritation

Intervention / Treatment
-----------------
* Device: Trojan Chameleon Personal Lubricant


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: male or female, 18-70 years of age, in general good health normal skin free of any systemic or dermatologic disorder which, in the opinion of the investigative personnel, will interfere with the study results or increase the risk of adverse events of any skin type or race providing the skin pigmentation will allow discernment of erythema agree to complete a medical history and concomitant medication form read, understand and sign informed consent Exclusion Criteria: have any visible skin disease at the study site which, in the opinion of the investigative personnel, will interfere with the evaluation are receiving systemic or topical drugs or medication which, in the opinion of the investigative personnel, will interfere with the study results have psoriasis and/or active atopic dermatitis/eczema have a known sensitivity to cosmetics, skin care test articles, or topical drugs as related to the test article being evaluated are females who are pregnant or breastfeeding or become pregnant

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Screening
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Healthy subject<br>Healthy subjects exposed to Trojan Chameleon Personal Lubricant applied by occlusive patch | Device: Trojan Chameleon Personal Lubricant<br>* silicone base with sensate<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of Subjects That Showed Erythema Based on 5 Point Scoring Scale |  | 14 days | 
| Number of Subjects That Showed Edema Based on the 5 Point Scoring Scale |  | 14 days |
The Effect of Nordic Exercise on Children's Agility

Study Overview
=================
Brief Summary
-----------------
The aim of this research is to investigate the effect of one-way and two-way Nordic exercise on the agility of active children. Children who meet the necessary criteria will be randomly assigned to one-way Nordic exercise group, two-way Nordic exercise group and control group by drawing lots. Volunteers in the training group will participate in a four-week training, two sessions per week. Agility will be assessed at baseline and after four weeks with the T-agility test. In-group and between-group comparisons will be analyzed using the Statistical Package for the Social Sciences program and appropriate tests.

Official Title
-----------------
Investigation of the Effects of One-Way and Two-Way Nordic Exercise on the Agility of Active Children

Conditions
-----------------
Sports Performance in Children

Intervention / Treatment
-----------------
* Other: One-way Nordic Exercise
* Other: Two-way Nordic Exercise


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Children between the ages of 8-12 To be actively participating in football training. Exclusion Criteria: Those with orthopedic, neurological and congenital problems. Those with any systematic disease. Those who have experience taping before. Those who have undergone any surgery within the last 1 year. Those who have been absent from training for more than 2 weeks in the last three months.

Ages Eligible for Study
-----------------
Minimum Age: 8 Years
Maximum Age: 12 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: One-way Nordic Exercise Group<br> | Other: One-way Nordic Exercise<br>* Participants in this group will be given the standard Nordic Hamstring exercise.<br>|
| Experimental: Two-way Nordic Exercise Group<br> | Other: Two-way Nordic Exercise<br>* In addition to the standard Nordic Hamstring exercise, participants in this group will do the same exercise backwards for the quadriceps.<br>|
| No Intervention: Control Group<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| T-Agility Test | Agility | 4 week | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
soccer, child, agility, nordic
Real-life Cohort Study on Patients With Chronic HBV Infection in Jiangsu

Study Overview
=================
Brief Summary
-----------------
Hepatitis B virus (HBV) infection remains one of the most serious health problems worldwide. Patients with chronic HBV infection are at an increased risk for developing hepatic cirrhosis, hepatocellular carcinoma and even death. Although some predictive factors of the outcome of chronic HBV infection were identified, more precisely determine the factors which are associated with the outcome in non-selected patients with chronic HBV infection are still needed. The investigators purpose is to constitute a observational cohort of non-selected Chinese patients to create a database of epidemiological, clinical, biological, virological, immunologic and therapeutic parameters, in order to determine factors associated with the outcome of chronic HBV infection.

Official Title
-----------------
Real-life Cohort Study on Patients With Chronic Hepatitis B Virus Infection in Jiangsu

Conditions
-----------------
Hepatitis B， Chronic

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with chronic HBV infection (defined as HBsAg positive for at least 6 months) Exclusion Criteria: Co-infection with human immunodeficiency virus (HIV), hepatitis C virus (HCV) and/or hepatitis D virus (HDV) History of liver transplantation History of hepatocellular carcinoma (HCC)
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of participants with antigen loss (HBeAg and HBsAg loss) |  | 20 years | 
| Cirrhosis |  | 20 years | 
| Hepatic decompensation | Development of hepatic decompensation will be defined by any of the following events: (1) Ascites or hepatic hydrothorax; (2)Variceal or portal hypertensive bleeding; (3)Hepatic encephalopathy | 20 years | 
| Hepatocellular carcinoma (HCC) | The diagnosis of HCC will be made using the American Association for the Study of Liver Disease criteria. | 20 years | 
| Death | Date and cause of death will be recorded. | 20 years |
Emergency Ultrasound of the Gallbladder

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine whether fasting for 8 hours prior to ultrasonography for cholelithiasis (gallbladder pain) is needed.

Detailed Description
-----------------
Ultrasonography of the gallbladder is currently the diagnostic modality of choice in determining cholelithiasis and cholecystitis. Historically this test has been performed in the Radiology suites where the patient was expected to fast for times of six to ten hours. Patients presenting to emergency departments (ED) have also been required to wait to have their study performed in order to have better visualization of the gallbladder. However, few studies have examined whether a fasting time matters in determining gallbladder pathology. Furthermore, with the emphasis on through-times in the ED, most EDs cannot afford holding their patients in the ED to wait for a test. Finally, with the advent of emergency bedside ultrasonography and the greater level of comfort emergency physicians (EP) have in diagnosing gallbladder pathology, it is possible to now determine an answer within minutes. We will test to see if EPs trained in the use of emergency bedside ultrasound can effectively and efficiently determine gallbladder pathology and if fasting has an impact on their ability to perform a quality ultrasound.

Official Title
-----------------
Emergency Bedside Ultrasonography of the Gallbladder: Does Fasting Matter?

Conditions
-----------------
Gallbladder Diseases

Intervention / Treatment
-----------------
* Procedure: Ultrasound


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Male or female between the ages of 18 and 75 Ability to consent for study Exclusion Criteria: Inability to give informed consent Known pregnancy Prior cholecystectomy Inability to consume a fast food breakfast Known history of cholelithiasis

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Ultrasound|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| time to perform scan |  |  | 
| diagnosis of pathology |  |  | 
| performance of adequate measurement |  |  | 
| overall adequacy of the scan |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Ultrasound, Gallbladder, Emergency Medicine
Can MicroRNA's Predict Multicentricity in Breast Cancer?

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to determine if microRNA's have role in predicting multicentricity in breast cancer. If a specific microRNA will be found to be related with multicentricity, it will help us to make appropriate decisions on the treatment of patients with multicentric breast cancer.

Detailed Description
-----------------
In the study that will be held at Bezmialem Vakif University Medical Faculty, General Surgery Department, 20 unifocal and 20 multifocal breast cancer patients will be included. Tissues will be taken from both tumoral and normal breast tissues and they will be saved in microRNA later solution under -80°C. Then, 84 microRNA's will be studied in these tissues to see if they express any of these microRNA's.

Official Title
-----------------
Can MicroRNA's Predict Multicentricity in Breast Cancer?

Conditions
-----------------
Multicentric Breast Cancer

Intervention / Treatment
-----------------
* Genetic: miRNA


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Having breast cancer Having no other malignancy Female patient Exclusion Criteria: Having other malignancy Under 18 years old Male patient

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: unifocal breast cancer<br>patients having unifocal breast cancer | Genetic: miRNA<br>* miRNA's expressed in breast cancer<br>|
| Active Comparator: multicentric breast cancer<br>patients having multicentric breast cancer | Genetic: miRNA<br>* miRNA's expressed in breast cancer<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| MicroRNA's in multicentric breast cancer | Evaluation of 84 microRNA's in patients with multicentric breast cancer | April 2014 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Treatment plan according to the detected microRNA in patients with multicentric breast cancer | If a specific microRNA will be detected in patients with multicentric breast cancer, treatment plan will be individualized according to the detected microRNA | April 2014 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
multicentric, breast, cancer
Incisional Negative Pressure Wound Therapy for Resection of Soft Tissue Tumors

Study Overview
=================
Brief Summary
-----------------
This study is aimed to examine the value of incisional negative pressure therapy after resection of soft tissue tumors. Its a prospective randomized trial comparing incisional negative pressure to standard wound dressings.

Detailed Description
-----------------
Wound healing after resection of large soft tissue tumors is often impaired by large dead space and fluid collection, potentially resulting in seroma formation and infection. Aim of the study is to compare negative pressure wound therapy to standard wound dressing in terms of quantity of drainage fluid and wound healing complications.

Official Title
-----------------
Inzisionelle Negative Drucktherapie Nach Resektion Von Weichteiltumoren - Eine Prospektive, Randomisierte, Kontrollierte Klinische Studie

Conditions
-----------------
Soft Tissue Sarcoma, Lipoma, Tumor

Intervention / Treatment
-----------------
* Other: Incisional negative pressure wound therapy
* Other: Wound dressing with adhesive tapes


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Soft tissue tumor of extremities or trunk with expected resection of >10cm tissue in any dimension. Exclusion Criteria: No primary skin closure. Skin infection in area of operation (e.g. acne inversa).

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: RCT with two therapy arms.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Control group<br>After subcuticular skin suture, patients receive standard dressing with adhesive wound tapes. | Other: Wound dressing with adhesive tapes<br>* Regular adhesive wound tapes are applied over the closed skin.<br>|
| Experimental: Incisional negative pressure group<br>After subcuticular skin suture, patients receive an incisional negative pressure dressing for 5 days. | Other: Incisional negative pressure wound therapy<br>* A negative pressure dressing is applied to the skin incision.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Amount of drainage fluid | Measurement of total fluid amounts in drains and negative pressure device | up to 14 days postoperatively | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Wound complications | Assessment of course of wound healing, necessary operative revisions, seroma formation | 3 months | 
| Wound margin perfusion | Measurement with laser doppler | 5 days postoperatively |
Treatment Outcomes and Quality of Life After IMRT Treatments of Head and Neck Cancers

Study Overview
=================
Brief Summary
-----------------
The purpose of the research study is to evaluate effectiveness and the quality of life, specifically the risk of dry mouth, after radiation treatment for head and neck cancers.

Official Title
-----------------
Treatment Outcomes and Quality of Life After IMRT Treatments of Head and Neck Cancers

Conditions
-----------------
Head and Neck Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria:Patients who complete radiation therapy for H&N cancers at Stanford University

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
4D Medical X-ray Velocimetry for Bronchoscopic Lung Volume Reduction Targeting

Study Overview
=================
Brief Summary
-----------------
This study will investigate the utility of 4D Medical's X-ray Velocimetry (XV) imaging analysis software for the detection of hyperinflation, and compare endobronchial valve placement outcomes with predictive indices obtained utilizing this technique.

Official Title
-----------------
4DXV for Targeting in Bronchoscopic Lung Volume Reduction

Conditions
-----------------
Copd, Emphysema, Hyperinflation

Intervention / Treatment
-----------------
* Diagnostic Test: 4D X-ray Velocimetry


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion: CT chest and PFTs within the last two years Age over 18 COPD with emphysema Global Initiative for Chronic Obstructive Lung Disease (GOLD) 3 - 4 classification OR modified Medical Research Council (mMRC) score of 2 or greater. Exclusion Criteria: Pregnancy Presence of an additional pulmonary disease beyond COPD Inability to raise arms above 90 degrees as required for fluoroscopy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: 4D X-ray Velocimetry|X-ray velocimetry uses fluoroscopy to quantify local ventilation in the lung.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ratio of residual volume over functional residual capacity by 4DXV | We will compare an XV hyperinflation index to traditional pulmonary function tests (PFTs) and outcomes | 6 months | 
| Expiratory Time Constants vs Fissure Completeness | We will examine the correlation between lobar expiratory time constants and fissure completeness by StratX | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Improvement in Saint George Respiratory Questionnaire (SGRQ) | We will compare SGRQs pre and post valve placement to hyperinflative indices by 4D XV | 1 year |