Chinese and Western Medicine Treatment of Fever Associated With Bleeding Symptoms

Study Overview
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Brief Summary
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To meet eligibility criteria, this study and informed consent of the syndrome of fever associated with bleeding of infectious diseases, severe patients to carry out multicenter, practical randomized controlled clinical research, to compare the curative effect of western medicine, combining Chinese and western medicine treatment, and security, and pathogenesis of TCM and syndrome, severe immune related factor and syndrome type of traditional Chinese medicine, Chinese medicine prescriptions mechanism research.

Detailed Description
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Randomized method: using large sample, central randomized, parallel comparison of Chinese and western medicine and western medicine group.

Official Title
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Syndrome of Fever Associated With Bleeding of Chinese and Western Medicine Diagnosis and Treatment of Infectious Diseases Plans and Severe Clinical Treatment Research

Conditions
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Viral Haemorrhagic Fever, Dengue Fever

Intervention / Treatment
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* Drug: Western Medicine
* Drug: TCM and Western Medicine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Viral diseases, such as dengue fever, kidney of hemorrhagic fever, such as xinjiang hemorrhagic fever; Or clinical has fever associated with bleeding as the main performance, and confirmed as the new emergent infectious diseases Exclusion Criteria: Diagnosed with flu, hand, foot and mouth disease, viral hepatitis (except the carrier), liver cirrhosis after hepatitis, AIDS, rabies, encephalitis, polio, measles, German measles, chickenpox, herpes, infectious mononucleosis, infectious atypical pneumonia

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: TCM and Western Medicine<br>TCM and Western Medicine:First Infectious diseases soup recipe,every time a dose,Two times a day;Ribavirin 10-15mg per kg every time Western Medicine：Ribavirin 10-15mg per kg every time | Drug: Western Medicine<br>* Physical cooling,Hydrocortisone<br>* Other names: Ribavirin,;Drug: TCM and Western Medicine<br>* Third Infectious diseases soup recipe<br>* Other names: Second Infectious diseases soup recipe and Ribavirin;|
| Placebo Comparator: Western Medicine<br>Western Medicine：Ribavirin 10-15mg per kg every time | Drug: TCM and Western Medicine<br>* Third Infectious diseases soup recipe<br>* Other names: Second Infectious diseases soup recipe and Ribavirin;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality |  | Anytime of the clinical trail from 2011.1.1 to 2015.12.30 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Safety outcome | With adverse events as the calculation basis | From 2012.1 to 2015.12 |