Female Fertility Outcome Following Bariatric Surgery: Five Years Follow up

Study Overview
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Brief Summary
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Maternal morbid obesity is an important risk factor in modern obstetrics, it has been associated with higher infertility rates and obstetrics complications. Bariatric surgery proven to achieve long term weight loss with improvement in all obesity related morbidities. This study was to compare the 5 years outcomes of laparoscopic sleeve gastrectomy (LSG) and laparoscopic Roux-en-Y gastric bypass (LRYGB) in terms of fertility outcomes, breast feeding, weight loss, safety, and resolution of obesity related co-morbidity.

Detailed Description
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This study included 197 adult morbidly obese females, 111 underwent LSG (group I) and 86 LRYGB (group II). After 5 years follow up, the following were looked at: percentage excess weight loss (%EWL), comorbidity improvement or resolution, postoperative complications or mortality, fertility outcomes and breast feeding.

Official Title
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Female Fertility Outcome Following Bariatric Surgery: Five Years Follow up, Single Center Study

Conditions
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Female Fertility and Bariatric Surgery

Intervention / Treatment
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* Procedure: Laparoscopic Sleeve Gastrectomy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with primary goal of conceiving and complaining from infertility either primary or secondary as well as those who were seeking weight loss in preparation for marriage Exclusion Criteria: -

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Female

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Laparoscopic Sleeve Gastrectomy (group I)<br>111 morbid obese females underwent LSG (group I). After 5 years follow up, the following were looked at: percentage excess weight loss (%EWL), comorbidity improvement or resolution, postoperative complications or mortality, fertility outcomes and breast feeding. | Procedure: Laparoscopic Sleeve Gastrectomy<br>* bariatric surgeries and data collection<br>* Other names: Laparoscopic Roux-en-Y Gastric Bypass;|
| Laparoscopic Roux-en-Y Gastric Bypass (group II)<br>86 morbid obese females underwent LRYGB (group II). After 5 years follow up, the following were looked at: percentage excess weight loss (%EWL), comorbidity improvement or resolution, postoperative complications or mortality, fertility outcomes and breast feeding. | Procedure: Laparoscopic Sleeve Gastrectomy<br>* bariatric surgeries and data collection<br>* Other names: Laparoscopic Roux-en-Y Gastric Bypass;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measuring the number of females that got pregnant from79 females seeking pregnancy | effect of LSG and LRYGB on female fertility and getting pregnant | Five years follow-up | 
| percentage excess weight loss after bariatric surgery | effect of LSG and LRYGB on percentage excess weight loss after bariatric surgery on females | Five years follow-up | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| comorbidity improvement or resolution after bariatric surgery | effect of LSG and LRYGB on comorbidities on females | Five years follow-up | 
| postoperative complications or mortality after bariatric surgery | postoperative complications or mortality after LSG and LRYGB in obese females | Five years follow-up |