Risk Factors for Recurrence of Primary Bile Duct Stones

Study Overview
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Brief Summary
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Recurrent common bile duct stone is one of the risk factors of recurrent cholangitis. However, the exact pathophysiology or mechanism of recurrent cholangitis has not been established. Periampullary diverticulum and narrow angle of common bile duct have been postulated as risk factors of recurrent common bile duct stone. The aim of this study was to evaluate the association between periampullary dierticulum, angle of common bile duct and recurrent common bile duct stone.

Detailed Description
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Recurrent common bile duct stone is one of the risk factors of recurrent cholangitis. However, the exact pathophysiology or mechanism of recurrent cholangitis has not been established. Periampullary diverticulum and narrow angle of common bile duct have been postulated as risk factors of recurrent common bile duct stone. The aim of this study was to evaluate the association between periampullary dierticulum, angle of common bile duct and recurrent common bile duct stone. This study is patient-control setting study. Firstly, from July 2007 through February 2014, all the patients who were performed ERCP will be enrolled. The inclusion criteria is the patients with common bile duct stone. The exclusion criteria is patients with biliary stenosis, PSC, retained GB stone, or who were lost to follow-up. The main outcome is the association between periampullary diverticulum, common bile duct angle, and recurrent CBD stone. This will be evaluated by univariate and multivariate analyses.

Official Title
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Case-control Study of Risk Factors for Recurrence of Primary Bile Duct Stones

Conditions
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Common Bile Duct Stones

Intervention / Treatment
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* Other: The existence of periampullary diverticulum
* Other: CBD angle


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients who were performed ERCP due to CBD stone or calculous cholangitis Exclusion Criteria: Patients with biliary stricture, PSC, retained GB stone, or who were lost to follow-up.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with recurrent CBD stone<br> | Other: The existence of periampullary diverticulum<br>* Periampullary diverticulum has been postulated as risk factor of recurrent CBD stone.<br>Other: CBD angle<br>* Narrow CBD angle has been postulated as risk factor for the development of recurrent CBD stone<br>|
| Patients without recurrent CBD stone<br> | Other: The existence of periampullary diverticulum<br>* Periampullary diverticulum has been postulated as risk factor of recurrent CBD stone.<br>Other: CBD angle<br>* Narrow CBD angle has been postulated as risk factor for the development of recurrent CBD stone<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The association between existence of periampullary diverticulum and recurrent CBD stone | The association between existence of periampullary diverticulum and recurrent CBD stone will be assessed by univariate analysis.(unit of analysis: odds ratio, statistical method: Fisher's exact test) | retrospective (up to 8 years) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The association between common bile duct angle and existence of recurrent CBD stone | The association between common bile duct angle and recurrent CBD stone will be assessed by univariate analysis (unit of analysis: angle, statistical method: student's t test) | retrospective (up to 8 years) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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diverticulum, common bile duct stones