The Relationship Between Autobiographical Memory and Motivation

Study Overview
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Brief Summary
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People with a diagnosis of psychosis often experience low motivation and pleasure when thinking about doing future activities. This leads, quite understandably, to doing fewer activities they used to enjoy and not taking up opportunities to do new activities. One model suggests that this may be partly due to difficulties using memories of previous events to help boost motivation and anticipation before a future activity. Research shows that people with psychosis may recall previous events in less detail. These memories therefore may not be as helpful as they could be for motivation. This study will investigate this by asking people with experience of psychosis and low motivation who are seen by a care team in South London and Maudsley NHS Trust to attend two research sessions. In the first session they will be asked to recall memories of events from their lives and the researcher will assess how detailed they are and how much they refer to the past and future. Alongside this task people will also be asked to complete measures of symptoms such as low pleasure and motivation as well as a measure of depression. These will be used to find out if the detail and specificity of the memories are related to these symptoms in people with psychosis. The second half of the study will then investigate whether additional prompts to support positive memory retrieval can increase the specificity of this and subsequently improve mood, motivation and self-belief. Participants will be randomised to one of two groups. The clinical group will be guided through their memory recall using prompts and a control group will be asked to recall positive memories without prompts. If we show that supporting memory recall is beneficial then memories for past events may be an important target for future therapies.

Official Title
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Is There a Relationship Between Memory for Past Events and Motivation for Future Activities?

Conditions
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Psychosis

Intervention / Treatment
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* Behavioral: Guided Autobiographical Memory Recall


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: A diagnosis of non-affective psychosis (as determined by medical records). Above 18yrs old. A score of at least 18 on the Clinical Assessment Interview for Negative Symptoms. A sufficient command of the English language to engage with the research materials Exclusion Criteria: Lack of capacity to provide informed consent. Primary diagnosis of intellectual disability, head injury, substance misuse or known organic cause of psychosis

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Intervention<br>Guided autobiographical memory recall to enhance specificity and links to the future. | Behavioral: Guided Autobiographical Memory Recall<br>* Participants are asked to recall positive autobiographical memories with the assistance of prompts to promote specificity, generalisability and links to the future. The participants will also view a 5min psychoeducation video on the subject of memory specificity and motivation.<br>|
| No Intervention: Control<br>Recall without prompts or psychoeducation video. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Motivation | A change in ratings on a visual analogue scale assessing motivation to repeat the same activity recalled in the future.The scale is rated from 0-100 and a higher score indicated better outcome. This scale will be reported separately and not combined with others. | Immediately before and after completing the intervention (20mins apart) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Anticipatory Pleasure | A change in ratings on a visual analogue scale assessing how pleasant that activity is anticipated to be if repeated.The scale is rated from 0-100 and a higher score indicated better outcome. This scale will be reported separately and not combined with others. | Immediately before and after completing the intervention (20mins apart) | 
| Change in Self-efficacy | A change in ratings on a visual analogue scale assessing how able the participant feels to engage in that activity if repeated.The scale is rated from 0-100 and a higher score indicated better outcome. This scale will be reported separately and not combined with others. | Immediately before and after completing the intervention (20mins apart) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Negative Symptoms, Autobiographical Memory