Tear Osmolarity Over Time With Artificial Tears

Study Overview
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Brief Summary
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The effect of artificial tears on tear osmolarity

Detailed Description
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Tear osmolarity measures the amount of solutes in the human tear film. The higher the reading, the more likely the patient has dry eyes. Some say it has potential to be the gold standard of dry eye testing. The investigators study the tear osmolarity at different time points after instillation of artificial tears.

Conditions
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Dry Eye

Intervention / Treatment
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* Drug: Artificial tears


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Between the ages of 18 and over inclusive. Males or females Any race or ethnic background Patient is in generally good & stable overall health. Patient likely to comply with study guidelines & study visits. Informed consent signed. Subjective evaluation of symptom of dryness (SESoD): Score 2 (Mild) - Exclusion Criteria: Corneal refractive surgery within 6 months of this study. Intra-ocular surgery within 6 months or ocular laser surgery within 6 months. Pregnant or lactating women. Ocular pathology (includes glaucoma and cataract), which could impact results and/or place patient at risk. Corneal staining Grade 3 or higher No Restasis for past 3 months Discontinue topical medications for at least 1 week

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Refresh tears<br>Allergan's Refresh tears artificial tear | Drug: Artificial tears<br>* Instill one drop of artificial tears<br>* Other names: Allergan's Refresh tears, Alcon's Systane Ultra, Johnson and Johnson's Visine, AMO's blink tears;|
| Active Comparator: Systane Ultra<br>Alcon's Systane Ultra artificial tear | Drug: Artificial tears<br>* Instill one drop of artificial tears<br>* Other names: Allergan's Refresh tears, Alcon's Systane Ultra, Johnson and Johnson's Visine, AMO's blink tears;|
| Active Comparator: Visine<br>Visine artificial tear | Drug: Artificial tears<br>* Instill one drop of artificial tears<br>* Other names: Allergan's Refresh tears, Alcon's Systane Ultra, Johnson and Johnson's Visine, AMO's blink tears;|
| Active Comparator: Blink tears<br>AMO's blink tears artificial tear | Drug: Artificial tears<br>* Instill one drop of artificial tears<br>* Other names: Allergan's Refresh tears, Alcon's Systane Ultra, Johnson and Johnson's Visine, AMO's blink tears;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Tear osmolarity | Tear osmolarity measured with TearLab instrument | 2 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Dry eye