Relationship Between Computed Tomography Manifestation and Histopathological Classification of Thymic Epithelial Tumors

Study Overview
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Brief Summary
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the World Health Organization (WHO) has proposed a classification of histopathological thymic tumor and it significance in prognosis. Chest computed tomography (CT) is the most common method to evaluate thymic epithelial tumors before operation. Therefore, the question is to predict the histopathological type of thymic epithelial tumors before surgery based on CT-scan images , to help determine treatment strategy and prognosis. In Vietnam, there are no published literature on this issue.

Detailed Description
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Introduction: the World Health Organization (WHO) has proposed a classification of histopathological thymic tumor and it significance in prognosis. Chest computed tomography (CT) is the most common method to evaluate thymic epithelial tumors before operation. Therefore, the question is to predict the histopathological type of thymic epithelial tumors before surgery based on CT-scan images , to help determine treatment strategy and prognosis. In Vietnam, there are no published literature on this issue. Materials and methods: 2.1. Cross-sectional descriptive study on 53 patients with diagnosed of thymoma by CT and had postoperative histopathology results as thymic epithelial tumors 2.2. Time and Place: in Departement of CTVS, Military Hospital 103, Vietnam from 10/2013 to 7/2017. 2.3. methods: study in chest CT scan: Measure the maximun diameter of the tumor The contour: smooth contour or irregular contour The shape: round, oval and plaque base on the ratio between long axis and short axis of the tumor Some other characteristics: Degree of enhancement, Level of drug absorbed, Calcification, Invasion the local organs and Capsular destruction. Histopathological study: based on the 2004 WHO classification: Thymoma: type A, AB, B1, B2, B3 Thymic carcinoma Data processing: use software Epi Info 2000. Expectation of results Relationship between the size and histopathological type of thymic epithelial tumors. Comparison of some characteristics of the tumor on preoperative chest CT scans and histopathological type of thymic epithelial tumors

Official Title
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Evaluate the Relationship Between Computed Tomography Manifestation and Histopathological Classification of Thymic Epithelial Tumors

Conditions
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Thymoma

Intervention / Treatment
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* Other: CT and histopathological classification


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All of patient have a chest CT scan pre-operation and a result of thymic epithelial tumors postoperative histopathology Exclusion Criteria: Incomplete or loss the CT and postoperative histopathology

Ages Eligible for Study
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Minimum Age: 21 Years
Maximum Age: 71 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Interventional Model Description: Cross-sectional descriptive study on 53 patients with diagnosed of thymoma by CT and had postoperative histopathology results as thymic epithelial tumors
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: CT and histopathological classification<br>With each histopathological type of thymic epithelial tumors, we measure the maximun diameter in chest CT scan. Comparison of some characteristics of the tumor on preoperative chest CT scans and histopathological type of thymic epithelial tumors . | Other: CT and histopathological classification<br>* Cross-sectional descriptive study on 53 patients with diagnosed of thymoma by CT and had postoperative histopathology results as thymic epithelial tumors. Base on the characteristics in Chest CT scan in each postoperative histopathology results.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| maximun diameter of the tumor | Measure the maximun diameter of the tumor in chest CT scan | 1 month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Computed tomography, thymic epithelial tumors