Retrospective Longitudinal Study of Gestational Weight Gain Among Chinese Pregnant Women

Study Overview
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Brief Summary
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The purpose of this study is to investigate the reference ranges and rates of gestational weight gain among Chinese pregnant women, and to analyze the correlation between gestational weight gain and adverse outcomes.

Official Title
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Retrospective Longitudinal Study of Gestational Weight Gain Among Chinese Pregnant Women

Conditions
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Gestational Weight Gain

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Deliveries between January 2013 and December 2014; Gestational age between 37 weeks or older and less than 42 weeks; Registration with care documents at the first prenatal visit prior to the 15th gestational week; Had at least five follow-up visits until delivery. Exclusion Criteria: None
Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Preeclampsia | Maternal systolic pressure ≥140 mmHg and/or diastolic pressure ≥90 mmHg during gestation. Urine protein ≥5.0 g within 24h, urine volume <400 mL. HELLP syndrome or pulmonary edema present. | After 20th gestational weeks till delivery, about 5 months | 
| Eclampsia | Tonic-clonic seizures (convulsions) in preeclampsia patients, including convulsions and coma, not due to pre-existing or organic brain disorders. | After 20th gestational weeks till delivery, about 5 months | 
| ICP | Intrahepatic cholestasis of pregnancy. | After 14th gestational weeks till delivery, about 6 months | 
| Placenta previa | Placenta partially or entirely covered the lower uterine segment diagnosed using antenatal ultrasound. | During pregnancy till delivery | 
| Gestational diabetes | By oral glucose tolerance test between 24th and 28th gestational weeks (fasting glucose ≥5.1 mmol/L, 1-h glucose ≥10.0 mmol/L, 2-h glucose ≥8.5 mmol/L; one abnormal result sufficient). | After 24th gestational weeks, about 4 months | 
| Ruptured uterus | Rupture of maternal uterus confirmed by laparotomy. | During delivery | 
| Placental abruption | Abruption of a normally positioned placenta before delivery, diagnosed by clinical symptoms, ultrasound, fetal heart monitoring, or laboratory tests. | After 20th gestational weeks till delivery, about 5 months | 
| Postpartum hemorrhage | Postpartum bleeding volume ≥500 mL. | Within 24h after delivery | 
| Hepatic diseases | Hepatitis-B/C/E virus infection, acute fatty liver disease, or severe hepatitis. | During pregnancy, delivery or within 42 days of pregnancy termination, an average of 1 year | 
| Hematological diseases | Iron-deficiency anemia, thalassemia, hemophilia, idiopathic thrombocytopenic purpura, aplastic anemia, or disseminated intravascular coagulation. | During pregnancy, delivery or within 42 days of pregnancy termination, an average of 1 year | 
| Gynecological diseases | Uterine fibroids, ovarian cyst, cervical carcinoma, pelvic inflammation, or ovarian carcinoma. | During pregnancy, delivery or within 42 days of pregnancy termination, an average of 1 year | 
| Respiratory diseases | Pneumonia, bronchitis, asthma or pulmonary tuberculosis. | During pregnancy, delivery or within 42 days of pregnancy termination, an average of 1 year | 
| Thyroid disease | Hyperthyroidism or hypothyroidism. | During pregnancy, delivery or within 42 days of pregnancy termination, an average of 1 year | 
| ICU admission | Admission to intensive care unit. | During pregnancy, delivery or within 42 days of pregnancy termination, an average of 1 year | 
| Maternal death | Maternal death. | During pregnancy, delivery or within 42 days of pregnancy termination, an average of 1 year | 
| Macrosomia | Birth weight >4000 g. | within 1 month after delivery | 
| Infant of low-birth weight | Birth weight <2500 g. | within 1 month after delivery | 
| Neonatal ICU admission | Admission to neonatal intensive care unit. | Within 1 month after delivery | 
| Neonatal death | Neonatal death. | Within 1 month after delivery | 
| Large for gestational age | Neonatal weight, length, or head circumference above the 90th percentile for that gestational age. | Within 1 month after delivery | 
| Small for gestational age | Neonatal weight, length, or head circumference below the 10th percentile for that gestational age. | Within 1 month after delivery | 
| Neonatal defect | Neonatal defect. | Within 1 month after delivery | 
| Maternal adverse outcomes | There occurred one or more of preeclampsia, eclampsia, ICP, placenta previa, gestational diabetes, ruptured uterus, placental abruption, postpartum hemorrhage, hepatic diseases, hematological diseases, gynecological diseases, respiratory diseases, thyroid disease, ICU admission, or maternal death. | During pregnancy, delivery or within 42 days of pregnancy termination, an average of 1 year | 
| Neonatal adverse outcomes | There occurred one or more of macrosomia, low-birth weight, neonatal ICU admission, neonatal death, large for gestational age, small for gestational age, or neonatal defect. | Within 1 month after delivery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Gestational weight gain, Chinese pregnant women, Retrospective longitudinal study, China, IOM guideline, Adverse outcome, Model