A Clinical Pathway for Nursing Home Acquired Pneumonia

Study Overview
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Brief Summary
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Nursing home residents are frequently transferred to hospital for management of pneumonia. This often leads to hospital related complications and is a burden on the acute care health system. The purpose of this study is to assess whether managing residents with pneumonia and lower respiratory tract infection on site in the nursing home can reduce hospital admissions and can reduce complications and improve quality of life for residents. We have randomized residents with nursing home acquired pneumonia to on-site management, using a clinical pathway, versus usual care.

Detailed Description
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We conducted a cluster-randomized controlled trial where nursing homes were randomized to either use of a clinical pathway or usual care for management of nursing home acquired pneumonia. The clinical pathway included chest radiographs performed on-site in the nursing home by a mobile x-ray unit, use of hypodermocylysis (subcutaneous infusion) for re-hydration, administration of an oral antimicrobials, and use of pulse oximetry to assess oxygenation. The main outcomes were hospital admission rate and length of stay. Secondary outcomes included health related quality of life, rates of both infectious and non-infectious complications within four weeks of onset of symptoms; mortality rate of residents with pneumonia (death from all causes within 30 days of onset of symptoms. Time to stabilization of vital signs, as well as functional status at four weeks, were assessed.

Official Title
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A Randomized Control Trial of a Clinical Pathway for Nursing Home Pneumonia.

Conditions
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Pneumonia, Lower Respiratory Tract Infection

Intervention / Treatment
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* Procedure: a clinical pathway nursing home acquired pneumonia


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Symptoms or signs of lower respiratory tract infection as defined by standardized criteria. Exclusion Criteria: Residents were excluded if they were not expected to live longer than 30 days from the date of enrollment, had a previous anaphylactic or serious allergic reaction to quinolones, had advanced directives that they are not be transferred to hospital for treatment.

Ages Eligible for Study
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Minimum Age: 64 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Intervention<br>use of oral anti-microbials, portable chest radiographs, oxygen saturation monitoring, re-hydration and close monitoring by a research nurse | Procedure: a clinical pathway nursing home acquired pneumonia<br>* treatment in nursing homes according to a clinical pathway, which included use of oral anti-microbials, portable chest radiographs, oxygen saturation monitoring, rehydrations and close monitoring by research nurse<br>* Other names: Nursing Home Residents with Pneumonia;|
| No Intervention: Comparator<br>usual care | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hospital admission, length of stay |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Health related quality of life, |  |  | 
| complication rates, |  |  | 
| mortality, |  |  | 
| functional status, |  |  | 
| time to stabilization of vital signs |  |  | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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pneumonia, lower respiratory tract infection, clinical pathway, nursing home, long-term care, randomized control trial