The Mechanical Properties of Burned Muscles

Study Overview
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Brief Summary
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The investigate of mechanical properties of muscles in burned patients.

Detailed Description
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The hypermetabolic response to severe burn is characterized by muscle protein catabolism. Current opinion states that the hypermetabolic state resolves soon after complete wound closure. Clinically, we have witnessed that burned patient appear to be hypermetabolic and catabolic long after full healing of their wounds. Our goal in this study was to determine muscle mechanical properties (tone, stiffness and elasticity) after burn.

Official Title
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The Investigation of Muscle Mechanical Properties in Burned Patients.

Conditions
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Burns, Muscle Loss, Viscoelastic Properties, Stiffness

Intervention / Treatment
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* Diagnostic Test: Myotonometric measurement


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: burned patient major burn over %20 TBSA Exclusion Criteria: Amputation Dead Systemic disease and abuse

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 64 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Screening
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: burned group<br>burned patients | Diagnostic Test: Myotonometric measurement<br>* Myotonometric assessment can predict the muscle stiffness, tone and elasticity<br>|
| Experimental: control group<br>sedentary people | Diagnostic Test: Myotonometric measurement<br>* Myotonometric assessment can predict the muscle stiffness, tone and elasticity<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Stiffness | Myotonometric measurement was used to determine for muscle stiffness. Device has a probe that creates constant pre-excitations and generates short-term, low-force mechanical stimulations over skin. The stimulations induce damped natural oscillations in the tissue and the myoton device records these oscillations with an accelerometer. Muscle tone, elasticity, and stiffness are calculated separately by the device. | 6 week | 
| Elasticity | Myotonometric measurement was used to determine for muscle elasticity. Device has a probe that creates constant pre-excitations and generates short-term, low-force mechanical stimulations over skin. The stimulations induce damped natural oscillations in the tissue and the myoton device records these oscillations with an accelerometer. Muscle tone, elasticity, and stiffness are calculated separately by the device. | 6 week | 
| Tone | Myotonometric measurement was used to determine for muscle tone. Device has a probe that creates constant pre-excitations and generates short-term, low-force mechanical stimulations over skin. The stimulations induce damped natural oscillations in the tissue and the myoton device records these oscillations with an accelerometer. Muscle tone, elasticity, and stiffness are calculated separately by the device. | 6 week | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Burn, muscle, myotonometer, viscoelasticity, stiffness