Adiponectin, Leptin, h-CRP Values in Obese Children - Important Markers for Metabolic Syndrome?

Study Overview
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Brief Summary
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Obesity is a chronic inflammatory disorder in which leptin, adiponectin and C reactive protein (CRP) play an important role. This study aimed to investigate the relationship between markers of adiposity like leptin, adiponectin and high sensitive C reactive protein (hsCRP) in obese children, and to determine whether these adipokines are significant markers in defining metabolic syndrome in pediatric population

Detailed Description
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The idea that adipose tissue is just a form of energy storage has changed dramatically in recent years. Currently, adipose tissue is considered to be a true endocrine gland that fulfills multiple roles in regulating different biological functions. Communication between adipose tissue and the rest of the systems is accomplished through bioactive mediators (adipokines) Adipokines control energy homeostasis and are involved in metabolic, endocrine and immunological processes.This study aimed to investigate the relationship between markers of adiposity like leptin, adiponectin and high sensitive C reactive protein (hsCRP) in obese children, and to determine whether these adipokines are significant markers in defining metabolic syndrome in pediatric population.The current retrospective observational study was conducted at the Louis Turcanu Emergency Hospital Timisoara over a period of one year, from July 2013 and June 2014. All inborn patient files were analyzed as anonymised limited data sets from archived records of the Endocrinology, Diabetology and Cardiology department.

Official Title
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Adiponectin, Leptin, h-CRP Values in Obese Children - Important Markers for Metabolic Syndrome?

Conditions
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Obesity, Metabolically Benign

Intervention / Treatment
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* Other: MetS+
* Other: MetS-


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: obese children (BMI> 95th percentile) Exclusion Criteria: obesity caused by endocrine disease, syndromic obesity, systemic disease or acute illness.

Ages Eligible for Study
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Minimum Age: 4 Years
Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| MetS+<br>Obese group with metabolic syndrome/Data processing from Patient Medical Files | Other: MetS+<br>* Data processing from Patient Medical Files<br>|
| MetS-<br>Obese group without metabolic syndrome/Data processing from Patient Medical Files | Other: MetS-<br>* Data processing from Patient Medical Files<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Defining obesity in the pediatric population | Measuring weight in kilograms and height in meters in order to calculate BMI and represent it on the percentile graph. | Weight and height were measured on day 1 of admission. Obesity was defined as a BMI > the 95th percentile. | 
| Leptin changes in the obese children with metabolic syndrome | Evaluating leptin in the obese group with metabolic syndrome | Leptin levels were measured on day 1 of admission. Normal range was considered < 24ng/ml. | 
| Adiponectin changes in the obese children with metabolic syndrome | Evaluating adiponectin in the obese group with metabolic syndrome | Adiponectin levels were measured on day 1 of admittance in children aged between 4 and18 years. Levels 4-26 mcg/ml were defined as normal values. | 
| Assessing cardiovascular risk in the obese children with metabolic syndrome | Evaluating hsCRP in the obese group with metabolic syndrome | hsCRP levels were measured on day 1 of admittance in children aged between 4 and 18 years. Normal levels were considered between 0.1-2.8 mg/l | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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adipokines, metabolic syndrome, obese children