Evaluation of Different Orthodontic Tooth Movements Assisted With Injectable Platelet Rich Fibrin

Study Overview
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Brief Summary
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The present prospective clinical study will be undertaken for assessment of the effect of application of i-PRF on the rate of levelling and alignment, molar distalization& intrusion of anterior teeth in deep bite cases

Detailed Description
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Assessment of the effect of application of i-PRF on the rate of levelling and alignment, molar distalization& intrusion of anterior teeth in deep bite cases

Official Title
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Evaluation of Different Orthodontic Tooth Movements Assisted With Injectable Platelet Rich Fibrin: A Prospective Clinical Study

Conditions
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Effect of Platelet Rich Fibrin With Different Tooth Movements

Intervention / Treatment
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* Biological: injectable platelet rich fibrin


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria:An age range from 15-22 years. Severe crowding or protrusion requiring 1st premolars extractions followed by symmetrical canine retraction. All permanent teeth present, 3rd molars are excluded. Good oral and general health. No systemic disease/medication that could interfere with orthodontic tooth movement. No previous orthodontic treatment. - Exclusion Criteria:Patient diagnosed to have an indication for non-extraction approach. Poor oral hygiene or periodontally compromised patient. Patient with craniofacial anomalies or previous history of trauma, bruxism or parafunctions. -

Ages Eligible for Study
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Minimum Age: 15 Years
Maximum Age: 22 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Factorial Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Group I<br>Intervention side: application of i-PRF with distalization of maxillary first molar that will be performed on intervention sides according to a standardized protocol. | Biological: injectable platelet rich fibrin<br>* injectable platelet rich fibrin<br>|
| No Intervention: Group II<br>Control side: distalization of maxillary first molar that will be performed without any intervention | |
| Experimental: Group A<br>levelling and alignment assisted with Injectable Platelet-rich fibrin (i-PRF) according to a standardized protocol. | Biological: injectable platelet rich fibrin<br>* injectable platelet rich fibrin<br>|
| No Intervention: Group B<br>leveling and alignment will be commenced without Injection of Injectable platelet-rich fibrin (i-PRF) | |
| Experimental: Group a<br>Will includes 9 patients who will receive intrusive arch after leveling and alignment assisted Injectable Platelet-rich fibrin (i-PRF) according to a standardized protocol. | Biological: injectable platelet rich fibrin<br>* injectable platelet rich fibrin<br>|
| No Intervention: Group b<br>Will includes 9 patients who will receive intrusive utility arches after leveling and alignment without Injection of Injectable platelet-rich fibrin (i-PRF) | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| effect of injectable platelet rich fibrin on different tooth movements | rate of tooth movement | post interventional at 4 months |