Observational Study of Preoperative Screen for Substance Abuse

Study Overview
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Brief Summary
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Substance abuse is a growing problem world wide, and treatment of substance abusers in the perioperative period, especially for emergency operation is challenging. The objectives of this study are to determine the proportions of substance abusers in the trauma patients undergoing emergency operation by preoperative screen, observe the differences of consumption of anesthetics and other medications during perioperative period between substance abusers and non-abusers, as well as postoperative complications, and explore an optimal scheme for substance abusers.

Official Title
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Preoperative Screen for Substance Abuse in Trauma Patients Undergoing Emergency Operation: a Prospective Observational Study

Conditions
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Preoperative Screen for Substance Abuse in in Patients Undergoing Emergency Operation

Intervention / Treatment
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* Drug: Substance use


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients aged 16 70 years； Informed consent signed Exclusion Criteria: Aged<16 years or >70 years； Refuse to sign consent; Other conditions that may preclude the patients from the study, such as language barrier, psychiatric disorders, unable to attend research center for follow up. Patients who enrolled to another research study or are taking experimental medication in last 3 months prior to this study. Not suitable for the study, after assessment by the investigators.

Ages Eligible for Study
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Minimum Age: 16 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Substance abuser group<br>After preoperative screen by application of ICG test cassette, this group of patients are found current use of the certain substance(s). | Drug: Substance use<br>* Patients are found use of substances by preoperative screen<br>|
| Non-substance abuser group<br>After preoperative screen by application of ICG test cassette, this group of patients are not found use of any substance. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Proportion of substance abuser in all the emergency operation patients | The proportion will be calculated as the number of substance abusers / total number of enrolled calculated as the number of substance abusers / total number of enrolled patients | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Perioperative consumption of medications | Perioperative consumption of sulfentanil, midazolam, propofol, and muscle relaxant in substance abusers and non-abusers. | 1 day | 
| Incidence and severity of postoperative complications |  | 30 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Substance abuse, Emergency operation, Preoperative screen