Short- and Long-Term Renal Outcomes Following Lung Transplantation

Study Overview
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Brief Summary
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Evaluation of acute kidney injury, renal recovery and development of chronic kidney disease in patients undergoing lung transplantation

Detailed Description
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It is well described that acute kidney injury and development of chronic kidney disease significantly impact short- and long-term survival after lung transplantation. However, there is limited data about prevalence of kidney disease according to current KDIGO consensus guidelines. It is the aim of this study to describe short- and long-term renal outcomes following lung transplantation. Selected patients who underwent prospective pretransplant renal functional reserve testing with high oral protein load will be analyzed separately in respect to occurrence of acute kidney injury following lung transplantation and development of chronic kidney disease.

Official Title
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Short- and Long-Term Renal Outcomes Following Lung Transplantation- A Single-Centre Experience

Conditions
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Lung Transplantation, Acute Kidney Injury

Intervention / Treatment
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* Other: No intervention


Participation Criteria
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Eligibility Criteria
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For retrospective analysis for all patients undergoing lung transplantation: Inclusion Criteria: Older than 18 years Exclusion Criteria: Patients with eGFR <15ml/min/1.73m2 or with chronic dialysis treatment prior LTx Patients undergoing retransplantation and multiorgan transplantation For prospective study involving patients with pretransplant renal functional reserve testing Exclusion criteria: as above unable to perform renal functional reserve testing (e.g., due to critical illness) pre-existing acute kidney injury

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients undergoing LTx<br>Retrospective analysis of clinical data | Other: No intervention<br>* No intervention<br>|
| Patients with pretransplant renal functional reserve testing<br>Prospective analysis of clinical data | Other: No intervention<br>* No intervention<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Impact of acute kidney injury (AKI) after lung transplantation on long-term renal function decline. | AKI defined by KDIGO consensus criteria | 7 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Impact of sustained reversal versus non-recovery after AKI on long-term renal function decline after lung transplantation. | AKI and CKD defined by KDIGO consensus criteria | 3 years | 
| Risk factors associated with development of AKI and CKD after lung transplantation | AKI and CKD defined by KDIGO consensus criteria | 3 years | 
| Whether development of CKD is an independent risk factor for increased rejection rate and death after lung transplantation. | CKD defined by KDIGO consensus criteria | 3 years | 
| Association between pretransplant renal functional reserve with acute kidney injury after after lung transplantation. | AKI defined by KDIGO consensus criteria | 7 days | 
| Association between pretransplant renal functional reserve and renal function loss after lung transplantation. | 24h-creatinine clearance, estimated glomerular filtration rate | 1 year |