linjc16/ctgov huggingface dataset:
Comparison of Skin Incision Closure Material for the Transobturator Suburethral Sling Procedure

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to compare different skin closure materials for the transobturator suburethral sling procedure. Currently the investigators are using monocryl suture material as the standard for skin closure. This material has anecdotally show to be very irritating to patients who have had this type of surgery. Our study will compare the monocryl suture material with vicryl (polyglactin 910) and dermabond (2-octyl cyanoacrylate) skin glue. The investigators believe that vicryl suture material will be superior in comfort when compared to monocryl and dermabond for this type of procedure.

Conditions
-----------------
Pain, Postoperative, Irritation (Physical), Pelvic Pain

Intervention / Treatment
-----------------
* Procedure: Vicryl Suture
* Procedure: Dermabond


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Those patients receiving a transobturator suburethral sling procedure. Adults (>= 18years). Exclusion Criteria: Non-English speaking. Allergy to monocryl, vicryl, or dermabond.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Vicryl<br>These patients will receive the standard monocryl suture on their right sided inguinal incision and then will receive the vicryl material on the left. | Procedure: Vicryl Suture<br>* Vicryl suture material will be placed on the patients left sided incision.<br>* Other names: polyglactin 910;|
| Experimental: Dermabond<br>The patients will receive the standard monocryl suture on their right sided inguinal incision and then will receive dermabond skin glue on the left | Procedure: Dermabond<br>* Dermabond skin glue will be placed on the patients left sided incision.<br>* Other names: 2-octyl cyanoacrylate;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The level of severity of patient discomfort at their incision sites. |  | The patients will be assessed at their second week post operative visit. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cosmesis at the incision sites |  | The patients will be assessed at their 2nd week post operative visit | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Skin closure, dermabond, vicryl, monocryl, Suburethral sling, Transobturator Sling, Pain, Discomfort, Skin irritation
The Impact of Altered Arterioventricular Coupling on Central Cardiovascular Energy Delivery

Study Overview
=================
Brief Summary
-----------------
This study will assess the amount of energy that the heart will deliver to the central circulation and the efficiency of that energy transfer, in patients undergoing a coronary artery bypass graft operation. Measurements will be taken just after induction of anaesthesia and repeated just after the end of the operation. The total energy delivered by the heart will be calculated by multiplying a pressure curve from the artery in the hand with the instantaneous ultrasound recorded cardiac output flow curve. The energy responsible for the acceleration of the blood volume, known as oscillatory power will also be calculated. The energy transfer will be calculated using a mathematical model based upon other ultrasound and blood pressure recorded variables. We would like to see if any alteration in energy delivered is in part due to impairment in energy transfer or alteration of fraction of oscillatory power rather than a change in total energy production. We would also like to study if there are changes in the oscillatory power after cardiac bypass surgery. The patients will be sampled sequentially into the study. We are not aware of any such studies undertaken in humans previously.

Official Title
-----------------
The Impact of Altered Arterioventricular Coupling on Central Cardiovascular Energy Delivery

Conditions
-----------------
Cardiovascular Diseases

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Elective Coronary Artery Bypass Graft patients No contraindications to transoesophageal Echo Ejection fraction 40% or over Exclusion Criteria: Lack of consent Emergency operation Prosthetic aortic valve

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Arterioventricular coupling | The ratio between arterial elastance and ventricular elastance | 1 day | 
| Total Cardiac Power | The amount of energy per second delivered from the left ventricle to the arterial circulation | 1 day | 
| Oscillatory Cardiac Power | The part of total cardiac power which is responsible for acceleration of the blood volume during systole. | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cardiac Output | The hearts delivery of volume per minute | 1 day | 
| Heart rate | The amount of heart beats per minute | 1 day | 
| Systemic vascular resistance | The resistance to flow of the arterial tree | 1 day | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Cardiac Power, Oscillatory Power, Coronary Artery Bypass Graft, Arterioventricular Coupling
Prognostic Value of Stem Cell Related Markers

Study Overview
=================
Brief Summary
-----------------
The goal of the investigators study is to identify a prognostic marker that will evaluate the probability of recurrence in patients with stage 0-II breast cancer following surgery to remove the tumor.

Official Title
-----------------
Prognostic Value of Stem Cell Related Markers CD24, CD44, CD326 and EPCR, for Predicting Breast Cancer Recurrence in Tumor Stages 0-II

Conditions
-----------------
Breast Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Ductal Carcinoma in Situ DCIS + Microinvasion stages 1 or 11 without positive lymph nodes Exclusion Criteria: tumor specimen with higher than grade II BRACA 1 or BRACA 2 mutation Neoadjuvant chemotherapy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
breast cancer stages 0-II
Confocal Laser Endomicroscopy With Cresyl Violet for in Vivo Diagnosis of Gastric Intestinal Metaplasia

Study Overview
=================
Brief Summary
-----------------
Confocal laser endomicroscopy (CLE) is a novel endoscopic system which can provide approximately 1000-fold magnification of the gastrointestinal mucosa. Previous studies have demonstrated its diagnostic value for Gastric intestinal metaplasia (GIM) with the use of a contrast agent.Recently, Cresyl violet (CV) has been used in CLE to visualize tissue architecture in human ileum, colon or myenteric plexus.No investigation has reported the characterization of GIM imaged with CLE when using CV as staining dye

Official Title
-----------------
Cresyl Violet as a New Contrast Agent in Confocal Laser Endomicroscopy for in Vivo Diagnosis of Gastric Intestinal Metaplasia

Conditions
-----------------
Gastric Intestinal Metaplasia

Intervention / Treatment
-----------------
* Diagnostic Test: Cresyl violet


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients who had long-lasting upper gastrointestinal symptoms and aged 40 years or above patients with H. pylori infection, or known GIM or atrophic gastritis Exclusion Criteria: patients with a history of GI surgery advanced gastric carcinoma or any other malignancy in the GI tract acute upper GI bleeding patients with contraindications to CLE examination, such as coagulopathy, pregnancy, breast feeding, impaired renal or liver function patients refused to provide informed consent

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Cresyl violet<br> | Diagnostic Test: Cresyl violet<br>* cresyl violet is applicated at the concentration of 0.15% via a spraying catheter to visualize cellular and tissue architecture in the pCLE<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| feasibility of CV for identifying GIM | ratio of pCLE failure to visualize the cellular and subcellular structures | 1 month | 
| feasibility of CV for identifying GIM | ratio of pCLE failure to recognize lesions and their immediate characterization | 1 month | 
| newly pCLE criteria with CV application for GIM | ratio of diagnostic agreement between pCLE using CV and histopathological results | 1 month | 
| newly pCLE criteria with CV application for GIM | number of diagnostic agreement between pCLE with CV application and histopathological results | 1 month |
Multifactorial Risk Assessment for Breast & Ovarian Cancer Risk Detection

Study Overview
=================
Brief Summary
-----------------
The objective of this project is to validate a next-generation assay that utilizes both the protein biomarkers of our already established ovarian cancer risk assessment combined with a molecular profile in both germline and early somatic detection.

Official Title
-----------------
Multifactorial Risk Assessment for Breast & Ovarian Cancer Risk Detection

Conditions
-----------------
Adnexal Mass, Germline BRCA1 Gene Mutation, Germline BRCA2 Gene Mutation, Hereditary Breast and Ovarian Cancer

Intervention / Treatment
-----------------
* Other: OVA360


Participation Criteria
=================
Eligibility Criteria
-----------------
Key inclusion criteria: Female subject 18 years of age or older Cohort A specific inclusion criteria: • Diagnosed with a pelvic mass Cohort B specific inclusion criteria: Diagnosed with a pelvic mass Undergoing genetic testing through our commercial offering Cohort C specific inclusion criteria: • Subject must not have an identifiable adnexal mass and may, or may not, have a family history or a known familial genetic abnormality (germ line or identified in family cancer i.e. somatic DNA mutation) associated with ovarian cancer. Exclusion Criteria: n/a

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| COHORT A<br>Women with a pelvic mass, symptomatic or asymptomatic. | Other: OVA360<br>* Multifactorial Risk Assessment for Breast & Ovarian Cancer Risk Detection<br>|
| COHORT B<br>Women diagnosed with a pelvis mass undergoing genetic testing through our commercial offering. | Other: OVA360<br>* Multifactorial Risk Assessment for Breast & Ovarian Cancer Risk Detection<br>|
| COHORT C<br>Subject must not have an identifiable adnexal mass and may, or may not, have a family history or a known familial genetic abnormality (germ line or identified in family cancer i.e. somatic DNA mutation) associated with ovarian cancer. | Other: OVA360<br>* Multifactorial Risk Assessment for Breast & Ovarian Cancer Risk Detection<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| OVA360 | Identify the molecular key driver of Ovarian cancer and develop a diagnostic test for early Ovarian cancer detection | 12 months |
Tobacco Cessation Field Study for Adults in Recovery - 1

Study Overview
=================
Brief Summary
-----------------
The project's aim is to provide a targeted, computer-administered intervention to facilitate tobacco cessation for clients in alcohol treatment. The main focus of On the Air: A tobacco cessation program for adults in alcohol recovery is to reduce tobacco use of clients in alcohol treatment. The program will be offered through inpatient, residential, and outpatient treatment programs to help those struggling with alcohol addiction to understand, reduce, and stop tobacco use. Clients will develop a personalized tobacco cessation plan relevant to their readiness to quit tobacco use. Based on the metaphor of a television network, this tobacco cessation program contains information on personal risks, peer stories, cravings and withdrawal, a variety of interactive activities and tools, and also motivational feedback and tips to assist in the quitting process. Phase I was a proof of concept phase, in which we delivered a prototype CD-ROM on tobacco cessation. Phase II will involve completing the development of a functional CD-ROM tool which will be subjected to a clinical field trial with a group of adults (n=196) in treatment facilities for alcohol recovery. The clinical field study will involve finalizing the content, interface, and interactive features of the CD-ROM. We will also gather satisfaction data from both clients and counselors in the various treatment facilities.

Official Title
-----------------
Tobacco Cessation Clinical Field Study for Adults in Alcohol Abuse Recovery

Conditions
-----------------
Tobacco Use Disorder

Intervention / Treatment
-----------------
* Behavioral: Tobacco Use Disorder


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Carry a primary DSM-IV diagnosis of alcohol abuse or dependence Smoke at least one cigarette a day Be willing to sign informed consent and undergo initial assessment and follow-up Be willing to provide at least one collateral contact and collateral contact information

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: Tobacco Use Disorder|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Smoking Behavior |  |  | 
| Smoking Cessation |  |  | 
| Substance Abuse |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Tobacco
Classification of Periodontitis Revisited: A Cluster Analysis

Study Overview
=================
Brief Summary
-----------------
This study aims to identify phenotypic groups of patients with periodontitis by applying a cluster analysis.

Detailed Description
-----------------
This is a retrospective cross-sectional study based on a prospectively maintained database of consecutive patients attending the Departement of Periodontology at the Rothschild hospital. A cluster analysis will help to distinguish clinical and microbiological profils of periodontal patients.

Official Title
-----------------
Classification of Periodontitis Revisited: A Cluster Analysis

Conditions
-----------------
Periodontitis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with periodontitis either aggressive or chronic Exclusion Criteria: Patients who had received periodontal therapies or antimicrobial therapy within the 6 months preceding the examination

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical Attachment Loss (CAL) | measured in millimeters | one day | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Periodontitis, classification, Cluster analysis
The Evaluation of a Nasal Pillows Mask for the Treatment of Obstructive Sleep Apnea (OSA)

Study Overview
=================
Brief Summary
-----------------
This investigation is designed to evaluate the performance as well as the patients overall acceptance of the mask.

Detailed Description
-----------------
A minimum of 20 OSA participants who currently use a nasal pillows mask will be recruited for the trial. Participant will be on the trial for three weeks - first week will be a collection of Positive Airway Pressure (PAP) baseline data on the participant's usual mask. The participant will then use the trial mask in-home for 2 weeks. There is also an option of a two month extension if the participant wish to continue on the trial mask.

Official Title
-----------------
The Evaluation of a Nasal Pillows Mask for the Treatment of Obstructive Sleep Apnea (OSA)

Conditions
-----------------
Sleep Disordered Breathing, Obstructive Sleep Apnea

Intervention / Treatment
-----------------
* Device: F&P Deimos Nasal Pillows Mask


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adult (18+ years of age) Able to give consent Apnea hypopnea Index (AHI)≥ 5 on diagnostic night Prescribed PAP for OSA Existing nasal pillows user Exclusion Criteria: Inability to give consent Patients who are in a coma or a decreased level of consciousness Anatomical or physiological conditions making automatic positive airway pressure (APAP) therapy inappropriate (e.g. unconsolidated facial structure) Commercial drivers who are investigated by New Zealand Transport Agency Current diagnosis of carbon dioxide (CO2) retention Pregnant or may think they are pregnant

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: F&P Deimos Nasal Pillows Mask<br>Participants to use nasal pillows mask in-home for 2 weeks. | Device: F&P Deimos Nasal Pillows Mask<br>* Investigative Nasal Pillows Mask to be used for OSA therapy<br>* Other names: Deimos Mask;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ease of use | Subjective questionnaire | 2 weeks in home | 
| Acceptability | Subjective questionnaire | 2 weeks in home | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Objective leak data | Obtained from participants' device | 2 weeks in home |
Epidemiologic Data of Patients in a Teaching Hospital

Study Overview
=================
Brief Summary
-----------------
This small cross-sectional epidemiological study is designed to evaluate the prevalence of the following parameters in hospitalized patients in a tertiary teaching hospital (medical department only): kidney insufficiency obesity use of unfractionated heparins / low molecular weight heparins other drugs effecting the hemostatic system

Detailed Description
-----------------
This small cross-sectional epidemiological study is designed to evaluate the prevalence of the following parameters in hospitalized patients in a tertiary teaching hospital (medical department only): kidney insufficiency obesity use of unfractionated heparins / low molecular weight heparins other drugs effecting the hemostatic system

Official Title
-----------------
Prevalence of Impaired Renal Function in Medical Inpatients

Conditions
-----------------
Kidney Diseases, Obesity

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All patients hospitalized at the defined days (two days) at Kantonsspital Luzern, Department of Medicine
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
low molecular weight heparin, unfractionated heparin