The Imaging Genetic Study of Type 2 Diabetes and Depression

Study Overview
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Brief Summary
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To investigate the structural/functional abnormalities and the possible genetic endophenotypes of in the Type 2 Diabetes Patient With Depression.

Detailed Description
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Diabetes and depression are harmful to human health,but they often co-exist.At present, the pathophysiological mechanisms underlying the comorbidity of diabetes and depression are discussed, including hypothalamic-pituitary-adrenal axis dysfunction, inflammation, epigenetics, disturbed circadian rhythms, environmental and behavioral factors,neuroimaging,etc.the purpose of the investigator's study is to investigate the structural/functional abnormalities and the possible genetic endophenotypes of in the Type 2 Diabetes Patient With Depression.

Official Title
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The Study of Structural and Functional Brain Abnormalities and the Association With the Genetic Polymorphism in the Type 2 Diabetes Patient With Depression

Conditions
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T2DM

Intervention / Treatment
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* Device: Magnetic resonance


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: conform to type 2 diabetes, depression, diagnostic criteria of unrelated normal controls the han nationality patients; Aged 30 to 70 years of age, gender not limited; The patient or legal guardian have signed informed consent of patients. Exclusion Criteria: Magnetic resonance imaging has the contraindication, such as metal implants, claustrophobic, etc. With severe body diseases, including inflammatory diseases and autoimmune diseases; Current or past history of nervous system disease or brain injury. Merge other severe mental illness or existing psychotic symptoms; Always have a mania, hypomania attack; Has a history of substance abuse; Pregnant women and nursing mothers; Estimated compliance is poorer, not partners; Is being treated for a mental drug therapy, and ECT, TMS; Patients with a body mass index > 35; There are currently no taking corticosteroids, immune regulator, etc. Now or ever did not suffer from patients with other diagnosis to the dsm-iv axis I; Merge the endocrine system disease, thyroid, adrenal gland and pituitary gland diseases, etc.

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| controls<br> | Device: Magnetic resonance<br>* magnetic resonance spectrum of brain<br>|
| T2DM patients<br> | Device: Magnetic resonance<br>* magnetic resonance spectrum of brain<br>|
| depression patients<br> | Device: Magnetic resonance<br>* magnetic resonance spectrum of brain<br>|
| T2DM with depression patients<br> | Device: Magnetic resonance<br>* magnetic resonance spectrum of brain<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the neuroimaging of Type 2 Diabetes and Depression | the structure and function of Abnormalities in the T2DM Patients | from 2017-12 to 2019-12 |