Investigation of the Efficacies of a Resveratrol Formula on Improvement of Skin Conditions and Inflammatory Related Factors

Study Overview
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Brief Summary
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To assess a resveratrol formula on improvement of skin conditions and inflammatory cytokines in blood

Official Title
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Investigation of the Efficacies of a Resveratrol Formula on Improvement of Skin

Conditions
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Skin Conditions, Proinflammatory Cytokines

Intervention / Treatment
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* Dietary Supplement: Resveratrol drink
* Dietary Supplement: Placebo drink


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy volunteers aged above 20 years old Exclusion Criteria: Subject who is not willing to participate in this study. Patients with diseases of the skin, heart, liver, kidney, endocrine and other organs and patients with mental illness (according to medical history). Subjects who have known cosmetic, drug or food allergies, difficulty in digestive tract absorption or disorder. Female who is pregnant or nursing or planning to become pregnant during the course of the study. Received facial laser therapy, chemical peeling or UV overexposure in the past 4 weeks. Subjects who have large spots (area >3 square centimeter) or abnormal acne.

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Resveratrol drink<br> | Dietary Supplement: Resveratrol drink<br>* Subjects will consume a bottle of resveratrol drink for two months.<br>* Other names: Grape Yeast Compound Fruit Vegetable Beverage;|
| Placebo Comparator: Placebo drink<br> | Dietary Supplement: Placebo drink<br>* Subjects will consume a bottle of placebo drink for two months.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The change of skin moisture | Corneometer® CM825 was utilized to measure skin moisture. Units: arbitrary Corneometer® units 0-120 | 0, 4, and 8 weeks | 
| The change of skin elasticity | Cutometer® dual MPA 580 was utilized to measure skin elasticity (parameter R2). Units: μm penetration depth into the probe opening, expressed as curves | 0, 4, and 8 weeks | 
| The change of skin wrinkles | VISIA Complexion Analysis System was utilized to measure wrinkles. Units: arbitrary units | 0, 4, and 8 weeks | 
| The change of skin collagen density | DermaLab® USB - 20 MHz High Freq. Ultrasound probe was utilized to scan and analyze skin collagen density. Units: Intensity score | 0, 4, and 8 weeks | 
| The change of skin texture | VISIA Complexion Analysis System was utilized to measure skin texture. Units: arbitrary units | 0, 4, and 8 weeks | 
| The change of skin pores | VISIA Complexion Analysis System was utilized to measure skin pores. Units: arbitrary units | 0, 4, and 8 weeks | 
| The change of total antioxidant capacity of blood | Total Antioxidant Capacity Assay Kit | 0 and 8 weeks | 
| The change of TNF-alpha of blood | ELISA Kit | 0 and 8 weeks | 
| The change of IL-6 of blood | ELISA Kit | 0 and 8 weeks | 
| The change of IL-17 of blood | ELISA Kit | 0 and 8 weeks | 
| The change of IL-1β of blood | ELISA Kit | 0 and 8 weeks |