Different Modes of Ventilation During Cardiopulmonary Bypass

Study Overview
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Brief Summary
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66 patients divided into 3 groups with different modes of ventilation.

Detailed Description
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Sixty-six patients going through open-heart surgeries were included in the study, divided into 3 groups (P: pressure controlled ventilation, V: volume controlled ventilation, C: control) in accordance with the mode of ventilation. Patients studied for chest x-ray, lung ultrasound, arterial oxygen partial pressure to fractional inspired oxygen ratio (PaO2/FiO2), Alveolar-arterial oxygen gradient, static lung compliance and dynamic lung compliance, taken after induction of anesthesia, 1h post cardiopulmonary bypass, 1h after arrival to cardiac surgical unit.

Official Title
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Comparative Study Between Different Modes of Ventilation During Cardiopulmonary Bypass and Its Effect on Postoperative Pulmonary Dysfunction

Conditions
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Postoperative Pulmonary Dysfunction

Intervention / Treatment
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* Device: Volume controlled ventilation
* Device: Pressure controlled ventilation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients undergoingvalve surgeries Patients undergoing coronary artery bypass grafting surgeries Exclusion Criteria: Emergency cases. Off-pump surgeries. Patients with chronic lung diseases with forced expiratory volume in first second (FEV1) or forced vital capacity (FVC) less than 40% of the predicted value. Massive blood transfusion during surgery. Complicated surgeries. Redo surgeries. Patients with decompensated heart failure prior to surgery. Patients refusal

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Volume-controlled ventilation<br>During cardiopulmonary bypass period the patients were ventilated with volume-controlled ventilation | Device: Volume controlled ventilation<br>* Changing modes of ventilation during cardiopulmonary bypass<br>|
| Active Comparator: Pressure-controlled ventilation<br>During cardiopulmonary bypass period the patients were ventilated with pressure-controlled ventilation | Device: Pressure controlled ventilation<br>* Applying pressure controlled ventilation during cardiopulmonary bypass Period<br>|
| No Intervention: No ventilation<br>During cardiopulmonary bypass period the patients were disconnected from ventilator | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| chest x-ray | Chest x ray to detect any lung pathology or changes from baseline like pleural effusion, pulmonary edema or pneumonia | after induction of anesthesia, 1hour post cardiopulmonary bypass and 1hour after arrival to cardiac surgical unit. | 
| lung ultrasonography | Lung ultrasonography to detect any lung changes from baseline or development of consolidation, pulmonary edema or pleural effusion | after induction of anesthesia, 1hour post cardiopulmonary bypass and 1hour after arrival to cardiac surgical unit. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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cardiopulmonary bypass, pressure-controlled ventilation, volume-controlled ventilation, atelectasis, pleural effusion, lung compliance