PRF for Accelerating Palatal Healing

Study Overview
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Brief Summary
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Backgroung: Various agents are used to reduce post-operative complications associated with palatal donor site surgery for free gingival graft (FGG) harvesting. This study was conducted to evaluate the effects of platelet-rich fibrin (PRF) on palatal wound healing.

Detailed Description
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125 patients with isolated recessions were treated. The connective tissue graft was obtained by the de-epithelialization of a free gingival graft in both groups. Three different hemostatic treatments were randomized; PRF with cyanoacrilate adhesive (PRF group, n:42), cyanoacrilate adhesive alone (BC group, n:42) and sterile wet gauze compression (WG group, n:41). Immediate and delayed bleeding, pain, epithelialization, feeding habits and sensation scores were recorded for different time points.

Official Title
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The Effects of Platelet-Rich Fibrin on Palatal Wound Healing After Free Gingival Graft Harvesting: A Comparative Randomized Controlled Clinical Trial

Conditions
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Gingival Recession

Intervention / Treatment
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* Other: Platelet Rich Fibrin
* Other: Butyl cyanoacrylate
* Other: Wet gauze


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: no contraindications for periodontal surgery; full-mouth plaque score of <10% full-mouth bleeding score of <15%. Exclusion Criteria: previously undergone surgery for a graft harvested from the palate presence of systemic disease or taking medication known to interfere with periodontal health smokers possible coagulation disorders

Ages Eligible for Study
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Minimum Age: 21 Years
Maximum Age: 48 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Platelet Rich Fibrin<br>PRF was laid directly on the palatal wound immediately after harvesting the tissue graft and stabilized | Other: Platelet Rich Fibrin<br>* Immediate and delayed bleeding, pain, epithelialization, feeding habits and sensation scores were recorded after PRF placing on palatal wounds.<br>|
| Active Comparator: Butyl cyanoacrylate<br>Butyl cyanoacrylate was directly applied on the palatal wound after harvesting the tissue graft | Other: Butyl cyanoacrylate<br>* Immediate and delayed bleeding, pain, epithelialization, feeding habits and sensation scores were recorded after Butyl Cyanoacrylate application on palatal wounds.<br>|
| Placebo Comparator: Wet Gauze<br>Wet Gauze was placed for 1 minute on the palatal wound after harvesting the tissue graft | Other: Wet gauze<br>* Immediate and delayed bleeding, pain, epithelialization, feeding habits and sensation scores were recorded after wet gauze pressure on palatal wounds.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Epithelialization | Assessed according to the toluedine blue coloring | One month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sensibility disorders | visual analogue scale scores | One month | 
| feeding habits | visual analogue scale scores | One month | 
| Delayed bleeding | Bleeding assesment for post-operative one week | 1 week | 
| Immediate Bleeding | Bleeding assesment for post-operative one hour | 1 hour | 
| Pain | Visual Analague Scale scores | 3 months |