The Health-Promoting Role of Pears in Men and Women With Metabolic Syndrome

Study Overview
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Brief Summary
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The hypothesis of this study is that the daily consumption of 2 medium-sized pears for twelve weeks will improve blood pressure, lipid profiles, glycemic control and insulin resistance, inflammatory and oxidative status in men and women with metabolic syndrome. 50 men and women between the ages of 45 and 65 who have three of the five features of metabolic syndrome as defined by the Adult Treatment Panel III will be included in the study. After a two-week run-in phase, eligible men and women will be randomly assigned to one of two treatment groups: 1) 2 medium-sized pears; or 2) 50 g placebo powder daily for twelve weeks. After an initial telephone screening, all participants will be requested to report to the study site for their first visit. On the first visit (screening), participants will be provided with verbal and written explanation of the project. They will then be asked to sign an informed consent form, followed by measuring waist circumference, resting brachial blood pressure, fasting serum triglycerides, high density lipoprotein cholesterol, and glucose levels to confirm metabolic syndrome. Baseline assessments will be performed for medical history, medication use, dietary intake, and physical activity. Qualified participants will be scheduled for their second visit two weeks later (actual baseline data collection) and randomly assigned to their treatment group. On the second (baseline) visit between the hours of 6-11 A.M., blood pressure will be measured followed by blood draw and urine collection. Anthropometrics and body composition will be measured. Questionnaires regarding diet, physical activity, and gastrointestinal health will be performed. Participants will be provided with their assigned treatment and will receive standard instructions on how to fill out daily diaries for their treatment. All assessments will be repeated at 6- (third visit), and 12-week (final visit) intervals. All assessments and information will be collected after an overnight fast and 12 hours after the abstinence of caffeine and/or 24 hours after the last bout of moderate to heavy physical activity. After the initial 12 weeks, participants will undergo a 4-week washout period in which they will not consume either the intervention or the placebo. After the 4-week washout period, participants will crossover into the other group to receive either the intervention or placebo.

Official Title
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The Health-Promoting Role of Pears in Men and Women With Metabolic Syndrome

Conditions
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Metabolic Syndrome

Intervention / Treatment
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* Dietary Supplement: Pear
* Dietary Supplement: Placebo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Men and women Aged 45-65 years old Three of the following five features at the screening visit: Waist circumference of ≥ 40 inches for men and 35 inches for women Serum triglycerides ≥ 150 mg/dL Serum high density lipoprotein cholesterol levels < 40 mg/dL for men and <50 mg/dL for women Blood pressure ≥ 130/85 mm Hg Fasting blood glucose level ≥ 110 mg/dL Exclusion Criteria: Taking hypoglycemic, antihypertensive or cholesterol-lowering medications Diagnosed cardiovascular disease Uncontrolled hypertension (≥ 160/100 mmHg) Diabetes mellitus Other active chronic diseases such as cancer, asthma, glaucoma, thyroid, kidney, liver and pancreatic disease Participating in a weight loss program Heavy smokers (> 20 cigarettes per day) Heavy drinkers (> 12 alcoholic drinks per week)

Ages Eligible for Study
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Minimum Age: 45 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Placebo<br>12 weeks of consuming 50 g pear-flavored placebo powder mixed with 480 ml per day (1/2 in the morning and 1/2 in the evening at least 6-8 hours apart). | Dietary Supplement: Placebo<br> <br> |
| Experimental: Pear<br>12 weeks of consuming 2 medium-sized pears per day (1 in the morning and 1 in the evening at least 6-8 hours apart). | Dietary Supplement: Pear<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood Pressure | By measuring brachial blood pressure at rest. | 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Atherogenic Markers | By measuring lipid profiles and atherogenic risk ratios. | 12 weeks | 
| Inflammation | By measuring markers of inflammation. | 12 weeks | 
| Oxidative Stress | By measuring markers of oxidative stress. | 12 weeks | 
| Insulin Sensitivity | By measuring fasting glucose, insulin, homeostatic model of insulin resistance, and hemoglobin A1C. | 12 weeks | 
| Body Composition | By measuring fat mass and fat-free mass using dual-energy X-ray absorptiometry and anthropometrics. | 12 weeks | 
| Gastrointestinal Health | By using a validated Seven-Day Bowel Movement Questionnaire and serum levels of short-chain fatty acids. | 12 weeks |