Efficacy and Safety of Lingzhi in Patients With Early Parkinson's Disease

Study Overview
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Brief Summary
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The purpose of this study is to determine whether Lingzhi (Ganoderma), a widely used traditional Chinese Medicine is effective and safe in the treatment of Parkinson's disease when combined use with L-dopa.

Detailed Description
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This study is to focus on the effects of Lingzhi on non-motor symptoms of Parkinson's diseases as the primary outcome and on delaying the disease progression using the delay start design as the secondary outcome measurement. Two dosage groups and one placebo control group with total 360 subjects will be recruited. The treatment is one year.

Official Title
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A Randomized, Double-Blind, Placebo-Controlled, Dose-Finding Study to Assess the Efficacy and Safety of Lingzhi in Patients With Early Parkinson's Disease Receiving Stable L-dopa/DCI

Conditions
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Parkinson's Disease

Intervention / Treatment
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* Drug: Lingzhi (Ganoderma)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: willing and able to give informed consent age 30 years or older at time of diagnosis of Parkinson's disease have idiopathic Parkinson's disease, defined as: having at least 2 of the following 4 signs: resting tremor, bradykinesia, rigidity, or postural reflex impairment, at least one of which must be resting tremor or bradykinesia no secondary or atypical parkinsonism asymmetric features (current signs or history of asymmetric onset) response to L-dopa, by patient self-report Parkinson's disease duration of no more than 5 years receiving stable therapy of L-dopa/DCI for at least 3 months; acceptable dose range: 250 mg - 1000 mg L-dopa/DCI daily Hoehn and Yahr stage < 4 on stable L-dopa/DCI treatment Exclusion Criteria: have atypical parkinsonism due to drugs, metabolic disorders, encephalitis, or other neurodegenerative diseases have any other known medical or psychiatric condition that may compromise their participation in the study have taken another investigational drug within 90 days of baseline have a change in dosage of any other antiparkinsonian drug (eg, pramipexole, ropinirole, pergolide, bromocriptine, methylphenidate, anticholinergics, or amantadine) during the study or within 90 days prior to baseline have received treatment with dopamine blocking agents (including neuroleptic agents, antiemetic agents), dopamine-depleting agents (including reserpine or tetrabenazine) within 90 days prior to baseline do not consent to participate

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Lingzhi (Ganoderma)|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Motor Function |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cognition |  |  | 
| Mood |  |  | 
| Quality of Daily Life |  |  | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Traditional Chinese Medicine, Lingzhi