Detection of Subclinical Enthesitis by Ultrasonography

Study Overview
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Brief Summary
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Detection of subclinical enthesitis by ultrasonography

Detailed Description
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A total of 30 patients with psoriasis and 30 age-matched healthy controls, all without musculoskeletal diseases, will be recruited. They will undergo dermatological assessment and a blinded ultrasound (US) evaluation. Clinical assessment included demographics, severity of psoriasis and musculoskeletal clinical examination. Evaluation consisted of the detection of grey scale (GS) enthesitis and Power Doppler signal in enthesis areas. The Madrid Sonography Enthesitis Index (MASEI) scoring system was used to quantify the extent of sonographic entheseal abnormalities.

Official Title
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Detection of Subclinical Enthesitis by Ultrasonography in Psoriasis Patients With Psoriasis and Controls: by Ultrasonography; Incidence of Psoriatic Arthritis During Within One 1 Year

Conditions
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Enthesitis

Intervention / Treatment
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* Diagnostic Test: Ultrasound


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age≥18years Patients with psoriasis without musculoskeletal symptoms Healthy controls No joint involvement and no clinical symptoms and signs of enthesitis and synovitis Exclusion Criteria: Have history of gout or arthritis or peripheral neurological disease of lower extremity. Have history of trauma and intensive sport activity in last 2 weeks. Have received any systemic therapy (i.e. DMARD, NSAIDs, corticosteroids, immunosuppressants, retinoids or biological agents) in 3 months Pregnant or breast-feeding

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Psoriasis<br>They will undergo dermatological assessment and a blinded ultrasound (US) evaluation. | Diagnostic Test: Ultrasound<br>* Evaluation consisted of the detection of grey scale (GS) enthesitis and Power Doppler signal in enthesis areas of participants. The Madrid Sonography Enthesitis Index (MASEI) scoring system was used to quantify the extent of sonographic entheseal abnormalities<br>|
| Control<br>They will also undergo dermatological assessment and a blinded ultrasound (US) evaluation. | Diagnostic Test: Ultrasound<br>* Evaluation consisted of the detection of grey scale (GS) enthesitis and Power Doppler signal in enthesis areas of participants. The Madrid Sonography Enthesitis Index (MASEI) scoring system was used to quantify the extent of sonographic entheseal abnormalities<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Detection of Subclinical Enthesitis by Ultrasonography in Psoriasis Patients with Psoriasis and Controls: by Ultrasonography; Incidence of Psoriatic Arthritis During Within One 1 Year | Incidence of subclinical enthesitis,To investigate the incidence of subclinical enthesitis in patients with psoriasis | 1 year. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of participants with Risk factors of subclinical enthesitis | To find out predictor factors of subclinical enthesitis in patients with psoriasis. To assess increase in enthesis area and PsA incidence, and show a possible relationship with baseline findings in a prospective 1-year follow-up of patients with PsO. | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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subclinical enthesitis, psoriasis, ultrasound, psoriatic arthritis