Effects of Progressive Elastic Band Resistance Training

Study Overview
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Brief Summary
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Abnormal body composition with increased body fat mass and decreased lean body mass has been found in adults with Prader-Willi syndrome (PWS), contributing to reduced physical capacity and impairment. The aim of this study was to investigate whether progressive elastic band resistance training can improve physical motor performance and regional body composition in adults with PWS.

Detailed Description
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Six participants were enrolled in this pilot study. Following 24 weeks of progressive elastic band resistance exercise training, significant reduction was observed in their body weight, BMI, and regional extremities fat mass and percentage. Regarding the functional performances, there were also significant improvements in their hand grip strength, 3 meter timed up and go, 30 seconds sit to stand, and 2-min step up tests, as early as the 8th week of training. Balance function achieved significant improvements after 16 weeks of training.

Official Title
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Effects of Progressive Elastic Band Resistance Training on Body Composition and Motor Performance in Adults With Prader-Willi Syndrome: a Pilot Study

Conditions
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Prader-Willi Syndrome, Resistance Training

Intervention / Treatment
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* Device: PWS elastic band training group


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: PWS individuals who can cooperate with motor performances Exclusion Criteria: arthritis, fracture, or severe musculoskeletal deformities that would interfere with exercise training or motor performance severe cognitive impairment or parents who cannot read nor write.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: PWS elastic band training group<br>Genetically confirmed diagnosis of PWS participants were recruited. The PWS participants needed to have sufficient command of the Mandarin language to understand the study information and motivated to conduct the training program. | Device: PWS elastic band training group<br>* PWS participants received 9 sets exercises for the major muscle groups, over 24 weeks, three times a week, for a total of 72 sessions.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in the handgrip strength functional physical assessment | hand grip strength (pounds), | Changes from Baseline functional motor performance tests at 8 weeks, 16 weeks and 24 weeks | 
| Changes in the 30 second chair stand functional physical assessment | 30-second chair stand test (times) | Changes from Baseline functional motor performance tests at 8 weeks, 16 weeks and 24 weeks | 
| Changes in the timed up and go functional physical assessment | timed up-and-go test (seconds) | Changes from Baseline functional motor performance tests at 8 weeks, 16 weeks and 24 weeks | 
| Changes in the two minute step up functional physical assessment | 2 minute step up test (times) | Changes from Baseline functional motor performance tests at 8 weeks, 16 weeks and 24 weeks | 
| Changes in the balance functional physical assessment | Berg Balance Scale (0-56 points; 0-20= high fall risk; 21-40= medium fall risk; 41-56= low fall risk) | Changes from Baseline functional motor performance tests at 8 weeks, 16 weeks and 24 weeks | 
| Change in the BMI body composition | Body weight (km) and height (m) will be combined to report as BMI (kg/m2) | Change from Baseline body composition components at 6 months | 
| Change in the percentage of body fat of body composition | Regional percentage body fat (%) | Change from Baseline body composition components at 6 months | 
| Change in the body fat mass of body composition | Fat mass (kg) | Change from Baseline body composition components at 6 months | 
| Change in the lean body mass of body composition | Lean body mass (kg) | Change from Baseline body composition components at 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Prader-Willi Syndrome, Resistance Training, Body Composition