Oxygen Consumption in Post-stroke Patients During Various Walking Activities Compared to Healthy Controls

Study Overview
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Brief Summary
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Stroke is major public health issue. The investigators recommend post-stroke patients to practice physical activity. Nevertheless, the recommendations are not widely respected due to the intensity of exercises. Oxygen consumption is a parameter to assess the intensity of physical activity. in this sense, we want to measure the oxygen consumption during various walking tasks compared to healthy controls.

Detailed Description
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Stroke is defined as an interruption of blood circulation in the brain. The treatments are in first time medical in emergency. Then, the patient will start his rehabilitation with several contributors. At this time, it will recommend physical activity to patients. Regardless of the all benefits of physical activity, it will help patient to avoid a second stroke. The investigators have the recommendations of the high authority of health in physical activity for stroke population. It recommends to practice around 20 to 60 minutes daily of physical activity with moderate effort intensity. Oxygen consumption is a parameter of effort intensity of physical activity measured in ml O2/kg/min. Currently, the investigators have the compendium of physical activity (PA). it allows us to classify PA according to effort intensity. And so, an activity with a moderate effort intensity is an activity between 3 and 5.9 metabolic equivalent task (MET). Note that 1 MET is 3.5 ml/O2/Kg. Nevertheless, this compendium does not correspond to post-stroke individuals. As consequences, Low intensity exercise as described in guidelines might be at a moderate intensity level for stroke survivors. Hence, the investigators want to assess the oxygen consumption of post-stroke individuals during various walking tasks and compare it to healthy controls.

Official Title
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Oxygen Consumption in Post-stroke Patients During Various Walking Activities Compared to Healthy Controls

Conditions
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Cerebrovascular Accident

Intervention / Treatment
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* Procedure: walking tasks


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Common to both groups: Age >=18 years Able to give consent Not under guardianship or curatorship Enrolled in the French social security system Specific to the cerebrovascular accident Group: Stroke confirmed by brain imaging Able to walk stairs without human assistance (modified Functional Ambulation Classification >= 6) Healthy Group Specific: - Individuals matched to stroke individuals on age sex and BMI. Exclusion Criteria: Cerebrovascular accident group - Severe cognitive impairment (MoCA < 18) Common to both groups: - Presence of contraindication to physical activity: unstable diabetes, unstable hypertension, unstable angina, intra-cardiac thrombus.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Monocentric, cross-sectional and comparative study
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Cerebrovascular Accident<br>Stroke patients will perform 2 walking tests indoors and outdoors wearing a gas exchange analyzer, an accelerometer and a heart rate monitor meter | Procedure: walking tasks<br>* The experiment will be divided in two sessions. In the first session, the participant/healthy volunteers will do 3 walking tasks (over ground walking/ climbing up, down stairs). In the second session, the participant will walk outside in front of the hospital (walking on a slope, walking down, walking on uneven ground). All those tasks will be done while wearing a gas exchange analyzer, accelerometer and a heart rate meter.<br>|
| Other: healthy volunteer<br>Healthy volunteers patients will perform 2 walking tests indoors and outdoors wearing a gas exchange analyzer, an accelerometer and a heart rate monitor meter | Procedure: walking tasks<br>* The experiment will be divided in two sessions. In the first session, the participant/healthy volunteers will do 3 walking tasks (over ground walking/ climbing up, down stairs). In the second session, the participant will walk outside in front of the hospital (walking on a slope, walking down, walking on uneven ground). All those tasks will be done while wearing a gas exchange analyzer, accelerometer and a heart rate meter.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Oxygen consumption measurement | Oxygen consumption by indirect calorimetry (respiratory gas exchange analyzer: Metamax) expressed in mL.min-1.kg-1 | Day 1 | 
| Oxygen consumption measurement | Oxygen consumption by indirect calorimetry (respiratory gas exchange analyzer: Metamax) expressed in mL.min-1.kg-1 | Day 7 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Walking speed measurement | Average walking speed measured (distance walked/total time) during different travel activities | Day 1 | 
| Walking speed measurement | Average walking speed measured (distance walked/total time) during different travel activities | Day 7 | 
| Cardiac frequency measurement | Average heart rate during activity measured by heart rate meter in bpm | Day 1 | 
| Cardiac frequency measurement | Average heart rate during activity measured by heart rate meter in bpm | Day 7 | 
| Perception of effort | Perception of effort by the Borg scale during the last minute of the movement activity | Day 1 | 
| Perception of effort | Perception of effort by the Borg scale during the last minute of the movement activity | Day 7 | 
| Total energy expenditure | Total energy expenditure during each movement activity estimated by an Actigraph GT3X placed at the healthy ankle | Day 1 | 
| Total energy expenditure | Total energy expenditure during each movement activity estimated by an Actigraph GT3X placed at the healthy ankle | Day 7 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Stroke, Oxygen consumption, physical activity