Diuresis, Functional Bladder Capacity and LUTS in CKD and ESRD Patients.

Study Overview
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Brief Summary
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The aim of the study is to evaluate the prevalence of LUTS in patients with moderate to severe (Stage IIIb), severe (Stage IV) CKD and ESRD : Stage V CKD) without renal transplantation (both pre-dialysis and dialysis patients). The study will also investigate the correlation between the diuresis, functional bladder capacity and LUTS in this population. By means of the obtained results, the investigators hope to be able to predict at which values of diuresis and functional bladder capacity these patients will start to develop LUTS. The investigators will also evaluate the impact of LUTS on the quality of life of these patients.

Detailed Description
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Pre-dialysis and peritoneal dialysis (home dialysis) and hemodialysis patients will be asked to fill in a 24h voiding diary the day prior to the control visit or dialysis session, or this can be registered the day of planned 24h urine collection. All patients will be asked to fill a ICIQ-LUTS questionnaire. The ICIQ-LUTS questionnaire is a validated questionnaire to investigate the presence of LUTS in a non-invasive way: ICIQ-FLUTS(female lower urinary tract symptoms) for female patients and ICIQ-MLUTS(male lower urinary tract symptoms) for male patients. Following patient data will be registered: Age Gender eGFR(estimated Glomerular Filtration Rate) (CKD-EPD) Cause of CKD-ESRD In case of dialysis: duration modality (hemodialysis or peritoneal dialysis) Antecedents Comorbidities Medication 24h voiding diary LUTS questionnaire

Official Title
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Diuresis, Functional Bladder Capacity and LUTS (Lower Urinary Tract Symptoms) in CKD (Chronic Kidney Disease) and ESRD (End Stage Renal Disease) Patients.

Conditions
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Lower Urinary Tract Symptoms, End Stage Renal Disease

Intervention / Treatment
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* Diagnostic Test: ICIQ questionnaire


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: >18years old GFR(CKD-Epi) < 45 ml/min and persisting minimal diuresis able to read and understand Dutch, French or English Exclusion Criteria: <18 years old eGFR (CKD-EPI) > 45 ml/min eGFR (CKD-EPI) < 45 ml/min and > 3 months absent persisting minimal diuresis unable to read and understand Dutch, French or English renal transplant recipients.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Health Services Research
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: ICIQ questionnaire<br> | Diagnostic Test: ICIQ questionnaire<br>* questionnaire<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| prevalence of LUTS in ESRD by ICIQ questionnaire | A ICIQ male or female LUTS questionnaire will be taken by investigator in all patient who signed IC. | up to 6 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| evaluation of bladder capacity in ESRD | Patient will be asked to keep an 24hour voiding diary This consist in keeping a record of the time of voiding and the volume of urine passed in ml each void. This will be measured in milliliter | up to 6 month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Lower Urinary Tract Symptoms, End Stage Renal Disease