Evaluation of Central Compartment Dissection Without Thyroidectomy

Study Overview
=================
Brief Summary
-----------------
In accordance with the current guidelines,papillary thyroid microcarcinoma such as turmo invasive nerve or trachea, requires total thyroidectomy for follow-up iodine-131 treatment.In the course of clinical work, if the patient can achieve R0 resection, most of the patients do not need iodine-131 treatment,Therefore, there is no need to continue total thyroidectomy.To evaluate the practicable, thoroughness and Clinical value of bilateral central compartment dissection while preserve contrary thyroid glands.

Detailed Description
-----------------
In accordance with the current guidelines,papillary thyroid microcarcinoma such as turmo invasive nerve or trachea, requires total thyroidectomy for follow-up iodine-131 treatment.In the course of clinical work, if the patient can achieve R0 resection, most of the patients do not need iodine-131 treatment,Therefore, there is no need to continue total thyroidectomy.This study assesses new procedures by adjusting the sequence of procedures. complications and the thoroughness of the operation were evaluated, thus Clinical value of bilateral central compartment dissection with preserve contrary thyroid glands were ananlyed.

Official Title
-----------------
To Evaluate the Practicable, Thoroughness and Clinical Value of Bilateral Central Compartment Dissection While Preserve Contrary Thyroid Glands

Conditions
-----------------
Thyroidectomy, Thyroid Cancer, Central Compartment Neck Dissction

Intervention / Treatment
-----------------
* Procedure: Conventional
* Procedure: central neck dissection first


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Tumor diameter less than 1cm The tumor is located in the lower part of the gland No lateral cervical lymph node metastases Traditional open surgery Exclusion Criteria: Select the endoscopic surgery or robotic surgery patients Tumor invades the surrounding trachea and esophagus Patients refused to participate

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Sham Comparator: Conventional operation group<br>Conventional operation group,Thyroidectomy was performed first, and central compartment dissection was performed. This is a routine procedure. | Procedure: Conventional<br>* Conventional operation ,Thyroidectomy was performed first, and central compartment dissection was performed. This is a routine procedure<br>|
| Experimental: central neck dissection first group<br>central neck dissection first group,after FNA confirmed of thyroid carcinoma, the central compartment neck dissection was carried out before thyroidectomy , finally complement of central compartment neck dissection. | Procedure: central neck dissection first<br>* central neck dissection first ,after FNA confirmed of thyroid carcinoma, the central compartment neck dissection was carried out before thyroidectomy , finally complement of central compartment neck dissection.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| number of the lymph node | the number of the lymph node | 2 day post operation | 
| number of postive lymph node | The number of postive lymph node | 2 day post operation | 
| The weight of the central compartment tissue. | The weight of the central compartment tissue. | introoperation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| thyroid volume | thyroid volume | The day before the operation | 
| recurrent laryngeal nerve palsy | the number of recurrent laryngeal nerve palsy | 1 day ,2weeks,3months,6months post operation |