Local Injection of PRP During Repair of Disrupted Surgical Wounds

Study Overview
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Brief Summary
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Patients with disrupted wounds will either managed as usual or managed by Platelet rich plasma local infiltration in the wound edges

Detailed Description
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The patients with disrupted surgical wounds will be cleansed, debrided and closed with infiltration of platelet rich plasma in one group and the other group will be closed without infiltration of Platelet rich plasma

Official Title
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Local Injection of Autologous Platelet Rich Plasma During Repair of Disrupted Surgical Wounds at Obstetrics and Gynecology Department: A Randomized Controlled Study

Conditions
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Role of Platelet Rich Plasma in Wound Healing

Intervention / Treatment
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* Procedure: Platelet rich plasma infiltration in the wound edges
* Procedure: Closure of wound without platelet rich plasma infiltration


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Disrupted surgical wounds after cesarean sections and other gynecological operations Body mass index 18-25 Hemoglobin > 10.5gm/dl Albumin >3.5gm/dl Exclusion Criteria: Medical disorders asDiabetes mellitus (DM), Liver disease or systemic lupus erythymatosus (SLE) Patient on corticosteriod therapy Thrombocytopenia Coagulation disorders

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: All cases with disrupted surgical wounds admitted at Obstetrics and Gynecology departments
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Intervention group<br>All patients in this group will be manged as usual with infiltration of platelet rich plasma in thee wound edges during closure of the wounds | Procedure: Platelet rich plasma infiltration in the wound edges<br>* platelet rich plasma will be injected in the wound edges<br>|
| Active Comparator: Control group<br>All patients in this group will be managed by repair of wounds without infiltration of platelet rich plasma | Procedure: Closure of wound without platelet rich plasma infiltration<br>* No infiltration of platelet rich plasma is done<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Complete wound healing | time needed for complete wound closure | 30 days | 
| Duration of hospital stay | Time during which patient is admitted | 30 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Failure of complete wound healing | No complete closure | 30 days | 
| Need fo tertiary suture | need to re-operate the case again | 30 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Platelet rich plasma, disrupted wounds, Obstetrics and Gynecology