Clinical Relevance of Different Training Intensities in Chronic Heart Failure.

Study Overview
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Brief Summary
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To determine the efficacy of different aerobic exercise training intensities in patients with chronic heart failure.Forty five eligible male patients with chronic heart failure were randomly assigned into three groups( High intensity , moderate intensity and low intensity)groups .

Detailed Description
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Forty five eligible male patients with chronic heart failure secondary to ischemic heart disease were selected from National Heart Institute heart failure outpatient clinic , their ages ranged from 50-60 years old and their ejection fraction ranged from 30-40% ,they were randomly assigned into three groups :HIT Group: received High Intensity aerobic Training in the form of bicycle ergometer exercise for the lower limbs three times /week for three months.(n=15) MIT Group: received moderate Intensity aerobic Training in the form of bicycle ergometer exercise for the lower limbs three times /week for three months. .(n=15) LIT Group: received low Intensity aerobic Training in the form of bicycle ergometer exercise for the lower limbs three times /week for three months, Before and after intervention, the following measures were obtained: Echocardiograph parameter (EF%, and left ventricular internal dimension ) , prognostic biomarkers (proBNP), and quality of life .

Official Title
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Clinical Relevance and Prognostic Outcomes of Different Training Intensities for Cardiac Remodeling in Chronic Heart Failure.

Conditions
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Chronic Heart Failure

Intervention / Treatment
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* Other: Aerobic exercise training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with following criteria were included : All patients ages were between 50 - 60 years old Fractional shortening < 25% and ejection fraction < 40% Sinus rhythm. Heart Failure due to ischemic heart disease. New York Heart Association (NYHA) class II-III. Regular medical treatment. Exclusion Criteria: Patients with following criteria were excluded : Chronic heart failure due to other causes History of pulmonary disease (chronic obstructive lung disease, moderate to severe pulmonary hypertension). Recent acute coronary syndrome or revascularization (3 months). Exercise limited by angina or peripheral arterial occlusive disease; Cerebrovascular or musculoskeletal disease preventing exercise testing or training. Poorly controlled or exercise-induced cardiac arrhythmias Logistic problems to attend regular exercise training sessions. Uncontrolled hypertension.

Ages Eligible for Study
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Minimum Age: 50 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: High intensity aerobic training group(HIT)<br>15 patients who received High Intensity aerobic Training in the form of bicycle ergometer exercise for the lower limbs three times /week for three months. | Other: Aerobic exercise training<br>* bicycle ergometer exercise training<br>|
| Active Comparator: Moderate intensity aerobic training group(MIT)<br>15 patients who received moderate Intensity aerobic Training in the form of bicycle ergometer exercise for the lower limbs three times /week for three months. | Other: Aerobic exercise training<br>* bicycle ergometer exercise training<br>|
| Active Comparator: Low intensity aerobic training group(LIT)<br>15 patients who received low Intensity aerobic Training in the form of bicycle ergometer exercise for the lower limbs three times /week for three months | Other: Aerobic exercise training<br>* bicycle ergometer exercise training<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ejection fraction | represents left ventricular function measured by pulsed echocardiography | change from baseline to after 12 weeks | 
| pro-brain natriuretic peptide (proBNP) | biomarker for heart failure measured by analysis of venous samples drawn | change from baseline to after 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Minnesota Living With Heart Failure Questionnaire (MLWHF): | Questionnaire for measuring quality of life of heart failure patients | change from baseline to after 12 weeks |