Systematic Review and Meta-Analysis of Venous Thromboembolism (VTE) Risk Assessment in Hospitalized Medical Patients

Study Overview
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Brief Summary
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A systematic review and meta analysis will be performed of risk assessment models for Venous thromboembolism (VTE including pulmonary embolism PE and deep venous thrombosis DVT)in hospitalized medical patients. The goal of this study is to evaluate whether the incidence of VTE is lower in patients that are evaluated with a risk assessment model and treated with thromboprophylaxis for their assigned level of risk.

Detailed Description
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Venous thromboembolism (VTE including pulmonary embolism PE and deep venous thrombosis DVT) is associated with significant morbidity and mortality. Only about half of eligible hospitalized medical patients receive appropriate thromboprophylaxis. Understanding VTE risk factors predictive of VTE among hospitalized medical patients may promote superior thromboprophylaxis. To date a systematic review of VTE risk assessment strategies among hospitalized medical patients, and a meta-analysis reporting the rate of VTE among patient groups at varying levels of risk for VTE does not exist. The investigators will use the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) checklist for reporting systematic reviews and meta-analyses to develop this systematic review and meta-analysis. The investigators will perform a systematic review of the literature and report VTE risk assessment models that have been derived and validated among hospitalized medical patients. The investigators will perform a meta-analysis of studies that report a rate of VTE among patients identified as being at elevated risk for VTE and those that are not. The investigators pre-specify that they are going to analyze the prospective and retrospective studies captured by the literature search in two ways. First, the investigators will perform an analysis that groups both prospective and retrospective studies together. The investigators will also perform an analysis that separates out the prospective and retrospective studies. While this will decrease our sample size (and thus power), this approach may allow us to identify any bias or confounding present due to the retrospective study design and then control for it. Notably confirmation that both retrospective and prospective studies identified the same findings would enhance the clinical usefulness of our findings.

Official Title
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Systematic Review and Meta-Analysis of Venous Thromboembolism Risk Assessment Models in Hospitalized Medical Patients

Conditions
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Venous Thromboembolism

Intervention / Treatment
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* Other: Application of VTE Risk Assessment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adults Hospitalized Exclusion Criteria: Surgical patients Pregnant patients

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Hospitalized Medical Patients<br>All hospitalized medical adult patients | Other: Application of VTE Risk Assessment<br>* Use of a method to assess a patient's risk of VTE, and then appropriate prophylaxis for the assigned level of risk<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| VTE | Objectively confirmed within individual studies | 28 to 180 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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VTE, DVT, PE, Risk assessment, risk score, risk analysis, Venous thromboembolism risk