Survival Among Patients With Pancreatic Cancer Depending on Surgical Resection Rate

Study Overview
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Brief Summary
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The primary aim of this population-based study is to investigate how a high resection rate of pancreaticoduodenectomy affects overall survival among patients aged ≥70 years with pancreatic ductal adenocarcinoma. The secondary aim is to determine if a high resection rate of pancreaticoduodenectomy increases perioperative morbidity.

Official Title
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Survival Among Elderly Patients in Sweden With Right-sided Pancreatic Adenocarcinoma Depending on Resection Rate of Pancreaticoduodenectomy

Conditions
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Pancreatic Ductal Adenocarcinoma

Intervention / Treatment
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* Other: Resection rates


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosed between 1 January 2010 and 31 December 2018 Registered in the Swedish National Registry for tumours in the pancreatic and periampullary region Either a diagnosis of pancreatic ductal adenocarcinoma of the pancreatic head or having been resected with pancreaticoduodenectomy Exclusion Criteria: None
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| All patients with pancreatic ductal adenocarcinoma aged 70 years and older<br>All patients in the registry aged 70 years and older with right-sided pancreatic ductal adenocarcinoma | Other: Resection rates<br>* All groups are divided into one high- and one low resection rate group depending on percentage of patients with pancreatic ductal adenocarcinoma resected per county and year (first three groups) and resection rate of pancreaticoduodenectomy per 100 000 inhabitants per county (last three groups)<br>|
| All patients with pancreatic ductal adenocarcinoma aged 70-79 years<br>All patients in the registry aged 70-79 years with right-sided pancreatic ductal adenocarcinoma | Other: Resection rates<br>* All groups are divided into one high- and one low resection rate group depending on percentage of patients with pancreatic ductal adenocarcinoma resected per county and year (first three groups) and resection rate of pancreaticoduodenectomy per 100 000 inhabitants per county (last three groups)<br>|
| All patients with pancreatic ductal adenocarcinoma aged 80 years and older<br>All patients in the registry aged 80 years and older with right-sided pancreatic ductal adenocarcinoma | Other: Resection rates<br>* All groups are divided into one high- and one low resection rate group depending on percentage of patients with pancreatic ductal adenocarcinoma resected per county and year (first three groups) and resection rate of pancreaticoduodenectomy per 100 000 inhabitants per county (last three groups)<br>|
| All patients resected with pancreaticoduodenectomy, all ages<br>All patients in the registry resected with pancreaticoduodenectomy during the study period | Other: Resection rates<br>* All groups are divided into one high- and one low resection rate group depending on percentage of patients with pancreatic ductal adenocarcinoma resected per county and year (first three groups) and resection rate of pancreaticoduodenectomy per 100 000 inhabitants per county (last three groups)<br>|
| All patients resected with pancreaticoduodenectomy, aged 70-79 years<br>All patients in the registry resected with pancreaticoduodenectomy during the study period, aged 70-79 years | Other: Resection rates<br>* All groups are divided into one high- and one low resection rate group depending on percentage of patients with pancreatic ductal adenocarcinoma resected per county and year (first three groups) and resection rate of pancreaticoduodenectomy per 100 000 inhabitants per county (last three groups)<br>|
| All patients resected with pancreaticoduodenectomy, aged 80 years and older<br>All patients in the registry resected with pancreaticoduodenectomy during the study period, aged 80 years and older | Other: Resection rates<br>* All groups are divided into one high- and one low resection rate group depending on percentage of patients with pancreatic ductal adenocarcinoma resected per county and year (first three groups) and resection rate of pancreaticoduodenectomy per 100 000 inhabitants per county (last three groups)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overall survival | Overall survival among patients aged 70 years and over with pancreatic ductal adenocarcinoma in the pancreatic head | A little more than 10 years (from first patient to vital status) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Severe complications after pancreaticoduodenectomy | The rate of severe complications among patients aged 70 years and over who had undergone pancreaticoduodenectomy for any reason | Around 10 years (patients diagnosed between 1 January 2010 and 31 December 2018, latest dismissal from hospital january 2020) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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pancreaticoduodenectomy