Clinical, Histological and Prognostic Forms of Adenocarcinoma of the Anus

Study Overview
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Brief Summary
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Adenocarcinoma of the anus is rare. It concerns less than 10% of anal cancers and its incidence is less than 0.2/100 000 inhabitants. Its management is not consensual and is most often derived by analogy with that of adenocarcinoma of the lower rectum. This is due to the rarity but also to the diversity of anatomical (anal margin, anal canal, lower rectum), etiological (primary glandular tumors or secondary to anal fistula, primary distant tumor and/or Crohn's disease) and histological forms (mucinous, intestinal, glandular adenocarcinomas and primary or secondary Paget's disease). Most of the literature consists of small case series and simple clinical cases in which the prognosis of these subforms has not been studied.

Official Title
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Clinical, Histological and Prognostic Forms of Adenocarcinoma of the Anus

Conditions
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Anal Adenocarcinoma

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient over 18 years of age French-speaking patient Patient with a diagnosis of adenocarcinoma of the anus between 01/01/2006 and 30/06/2022 in participating centers Exclusion Criteria: Patient under guardianship or curatorship Patient deprived of liberty Patient under court protection Patient objecting to the use of his data for this research

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Risk of mortality at 1 year, estimated using a survival curve | This outcome corresponds to the 1 year mortality rates after diagnosis of adenocarcinoma of the anus. | Year1 | 
| Risk of mortality at 5 years, estimated using a survival curve | This outcome corresponds to the 5 year mortality rates after diagnosis of adenocarcinoma of the anus. | Year5 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Describe the various anatomical, etiological and histological forms | This outcome corresponds to the classification of anatomical (anal margin, anal canal, lower rectum), etiological (primary glandular tumors or secondary to anal fistula, primary distant tumor and/or Crohn's disease) and histological (mucinous, intestinal, glandular adenocarcinoma and primary or secondary Paget's disease) forms. | Year5 | 
| Adaptaion of the therapeutic management according to the clinical and histological form | This outcome corresponds to the Proposed treatments (local excision, abdominoperineal amputation, neoadjuvant treatment, adjuvant treatment, etc.) according to the clinical and histological form. | Year5 | 
| Describe their therapeutic management | This outcome corresponds to the Proposed treatments (local excision, abdominal-perineal amputation, neoadjuvant treatment, adjuvant treatment, etc.). | Year5 | 
| Compare prognosis by clinical and histological form | This outcome corresponds to the Mortality rate by clinical and histological form. | Year5 | 
| Search for prognostic factors of severity in all forms | This outcome corresponds to the Prognostic factors of severity for all forms. | Year5 |