The CSTME Associates With the Prognosis of Stage II and III Colorectal Cancer

Study Overview
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Brief Summary
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Colorectal cancer (CRC) is the second most commonly occurring cancer worldwide. Thirty-five percent of CRC patients are diagnosed at stage II/III, and their outcome differs even if they are in the same stage. Previous study found that the microenvironmental collagen is associated with tumor progression and metastasis. Whether tumor microenvironmental collagen signature is associated with colorectal cancer prognosis still remains unknown. We hypothesize that the tumor microenvironmental collagen signature of colorectal cancer is associated with prognosis.

Detailed Description
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Colorectal cancer (CRC) is the second most commonly occurring cancer worldwide. Thirty-five percent of CRC patients are diagnosed at stage II/III, and their outcome differs even if they are in the same stage. In the seed and soil theory proposed by Stephen Paget, tumor cells play the role of the seed, and the tumor microenvironment (TME) is the soil. TNM classification provides useful but uncomplete prognosis information in colorectal cancer. It lacks the assessment of the soil signature of tumor microenvironment. Previous study found that the microenvironmental collagen is associated with tumor progression and metastasis. Whether tumor microenvironmental collagen signature is associated with colorectal cancer prognosis still remains unknown. This study is a retrospective observational study performed in two centers. The main purpose of this study was to investigate whether the tumor microenvironment collagen signature (CSTME) can discriminate the 5-year DFS of stage II/III CRC patients, the secondary purpose is to compare the AUC (area under the receiver operating characteristic curve) of TNM stage+CSTME in predicting 5-year DFS with that of TNM stage alone. This study would introduce the tumor microenvironmental collagen signature into current colorectal cancer classification system, which would provide reference for clinical practice.

Official Title
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The Tumor Microenvironment Collagen Signature (CSTME) Associates With the Prognosis of Stage II and III Colorectal Cancer : A Multi-Center Retrospective Observational Cohort Study

Conditions
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Colorectal Cancer

Intervention / Treatment
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* Other: CSTME


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Pathologically diagnosed with colorectal cancer TNM stages II and III (according to the 8th edition of AJCC Cancer Staging Manual) Received radical tumor resection surgery Exclusion Criteria: ASA grade 4 Preoperative radiotherapy and/or chemotherapy Hereditary colorectal cancer Pregnancy

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| High-CSTME<br>Patients with high tumor microenvironment collagen signature | Other: CSTME<br>* Tumor microenvironment collagen signature<br>|
| Low-CSTME<br>Patients with low tumor microenvironment collagen signature | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 5-year DFS | 5-year disease free survival | 5 years followup after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 5-year OS | 5-year overall survival | 5 years followup after surgery |