Are Sporadic Colorectal Cancers in Young Distinct From Elderly?

Study Overview
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Brief Summary
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In this study, the investigators compared and evaluated the clinicopathological and oncological characteristics of sporadic colorectal cancer (CRC) in young adults without genetic mutations associated with hereditary CRC syndrome and sporadic CRC in elderly individuals.

Detailed Description
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The ambiguity in the findings among several previous studies might be because of the difference in the age of the study population, yCRC and eCRC. The family history of CRC and cancer due to Crohn's disease or ulcerative colitis were also not excluded in such previous studies. Most importantly, those studies did not rule out the risk of hereditary cancer through the genetic testing in yCRC. Since hereditary CRC accounts for approximately 34% of those under the age of 35 years, it is necessary to exclude it to accurately compare the clinicopathological characteristics of sporadic cancer developed in yCRC and eCRC.

Official Title
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Are Sporadic Colorectal Cancers in Young Distinct From Elderly?

Conditions
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Colorectal Neoplasms

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Histologically confirmed cases of adenocarcinoma in the colon and rectum The age at the time of diagnosis should be ≤ 40 years (for yCRC) or ≥ 70 years (for eCRC) Genetic testing confirmation of non-hereditary cancer. Exclusion Criteria: Inflammatory bowel disease A family history of CRC A history of other cancers Underwent any emergency operation or palliative surgery The Amsterdam criteria with mutations in genes associated with APC, MLH1, MSH2, MSH6

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 100 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| young colorectal cancer (yCRC)<br>histologically confirmed cases of adenocarcinoma in the colon and rectum the age at the time of diagnosis should be ≤ 40 years | |
| elderly colorectal cancer (eCRC)<br>histologically confirmed cases of adenocarcinoma in the colon and rectum the age at the time of diagnosis should be ≥ 70 years | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overall survival outcome in young colorectal cancer (yCRC) and elderly colorectal cancer (eCRC) | The 3-year overall survival (OS) in yCRC and eCRC | The OS was defined as the time period from the date of surgery to the date of death or last follow-up up to 3 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cancer-specific survival outcome in young colorectal cancer (yCRC) and elderly colorectal cancer (eCRC) | The 3-year cancer-specific survival (CSS) in yCRC and eCRC | CSS was defined as the time period from the date of surgery to the date of death from CRC up to 3years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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young colorectal cancer patients, elderly colorectal cancer patients, sporadic colorectal cancer