Impact of Gonadotrophin REceptor Polimorphisms on the Relationship Between Serum AMH and Ovarian Response

Study Overview
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Brief Summary
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Aim of study: To compare the relationship between serum AMH and ovarian response for IVF with the GnRH antagonist protocol in patients who are carriers of FSH and/or LH receptor polymorphisms with those that are not.

Detailed Description
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Serum AMH has shown to have a high predictive capability of the ovarian response to stimulation for IVF. On the other hand, patients who are carriers of polymorphisms in the FSH and LH receptors, have shown to need higher doses of gonadotrophins for ovarian stimulation. The proportion of carriers has been described to be around 20% of the population. Nevertheless, the determination of these polymorphisms is not performed in routine practice. It is unknown if their presence affects to the relationship between serum AMH levels and ovarian response. This is a prospective, single center, non-interventional, cohorts study.

Official Title
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Impact of Gonadotrophin REceptor Polimorphisms on the Relationship Between Serum AMH and Ovarian Response

Conditions
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antimüllerian Hormone and Gonadotrophin Receptor Polymorphism as Predictors of Ovarian Response

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 18-45 years of age presenting to IVF clinic BMI of 18-35 kg/m2 Having been tested for serum AMH with the Elecsys assay Being planned to undergo ovarian stimulation cycle for IVF with the GnRH antagonist protocol Signed written informed consent or waiver Exclusion Criteria: Current or past disease affecting ovaries, gonadotropin or sex steroid Current hormone therapy

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| patients with FSH/LH polymorphisms<br>Infertile patients will undergo an ovarian stimulation with FSH and/or hMG. Doses will be chosen according to BMI, Antral follicle count, AMH and age. | |
| patients without FSH/LH polymorphisms<br>Infertile patients will undergo an ovarian stimulation with FSH and/or hMG. Doses will be chosen according to BMI, Antral follicle count, AMH and age. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Gonadotrophin receptor polymorphisms and ovarian response and AMH value | To compare the relationship between serum AMH and ovarian response for IVF with the GnRH antagonist protocol in patients who are carriers of FSH and/or LH receptor polymorphisms with those that are not. | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| polymorphisms in the FSH receptor (FSHR) variant N680S | To define the incidence of carriers of polymorphisms in the FSH receptor (FSHR) variant N680S (homozygous and heterozygous) among women undergoing ovarian stimulation for IVF. | 1 year | 
| polymorphisms in the LH receptor (LHR) variant N312S | To define the incidence of carriers of polymorphisms in the LH receptor (LHR) variant N312S (homozygous and heterozygous) among women undergoing ovarian stimulation for IVF. | 1 year | 
| Doses of gonadotrophin needed and polymorphisms | To analyse the doses of gonadotrophins needed for stimulation on each group of patients | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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gonadotrophin receptor polymorphism, antimüllerian hormone, ovarian response, ovarian stimulation