Psychological Evaluation According Colonic Colonization by Escherichia Coli of Patients After Colorectal Surgery

Study Overview
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Brief Summary
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The purpose of this study is to determine whether the presence of pathogenic Escherichia coli in colon is associated with psychiatric disorders.

Detailed Description
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Colonic colonization by pathogenic Escherichia coli was determined when patients were operated on for colorectal cancer. Several years later, the investigator investigate past and actual psychiatric disorder using the Mini International Neuropsychiatric Interview (MINI). Actual depression and anxiety scores are evaluated with Hamilton scales and personality traits are investigated using Personality Inventory for DSM-5 (PID-5). Anxiety and depression scores, psychiatric diagnoses (MINI) and personality traits were compared in patients according to Escherichia coli presence/absence.

Official Title
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Psychological Evaluation According Colonic Colonization by Escherichia Coli of Patients After Colorectal Surgery

Conditions
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Colorectal Cancer

Intervention / Treatment
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* Other: Psychiatric evaluation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients operated on for colorectal cancer in the digestive surgery department of Clermont-Ferrand hospital patients older than 18 years, patients whose Escherichia coli colonization was analyzed after surgery patients which are always followed by the digestive surgery department. Exclusion Criteria: Patients with dementia will not be included, according to the MMSE score: 22 if no grade 23 if study certificate or CAP or college without patent 25 if patent or school without the tray 26 or more when bin

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Screening
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: patients operated on for colorectal cancer<br> | Other: Psychiatric evaluation<br>* The purpose of this study is to determine whether the presence of pathogenic Escherichia coli in colon is associated with psychiatric disorders.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hamilton anxiety and depression score comparison | Hamilton anxiety and depression score will be compared between patients with Escherichi coli colonic colonization and patients without Escherichi coli | at day 1 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Psychiatric prevalence comparison | prevalence of each past and actual psychiatric disorder diagnosed by the Mini International Neuropsychiatric Interview (MINI: major depression, dysthymia, suicidal risk, hypomania, mania, panic disorder, agoraphobia, social phobia, specific phobia, obsessive-compulsive disorder, posttraumatic stress disorder, dependence and abuse of alcohol, tobacco- dependence, psychotic disorders and generalized anxiety disorder) will be compared in patients according to colonic colonization by Escherichia coli. | at day 1 | 
| personality traits comparison | personality traits investigated using Personality Inventory for DSM-5 (PID-5) will be compared in patients according colonic colonization by Escherichia coli | at day 1 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Escherichia coli, Microbiota, Colorectal cancer, Psychiatric disorders, Personality traits