Laryngeal Mask Airway (LMA) Insertion With Sevoflurane and Remifentanil

Study Overview
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Brief Summary
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The purpose of this study was to determine the most suitable effect-site concentration of remifentanil for the LMA insertion during inhaled induction with 8% sevoflurane in adults.

Detailed Description
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For practical purposes, opioids with the ability to suppress upper airway reflexes have been used to facilitate insertion of the LMA during anaesthesia induction. To date, however, there have been no published reports addressing the use of remifentanil to facilitate LMA insertion during sevoflurane inhalation induction in adults. Therefore, the purpose of this study was to determine the most suitable effect-site concentration of remifentanil target-controlled infusion (TCI) for the LMA insertion during inhaled induction with 8% sevoflurane in adults.

Official Title
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Target-controlled Infusion of Remifentanil for Laryngeal Mask Airway Insertion During Sevoflurane Induction in Adults

Conditions
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Laryngismus

Intervention / Treatment
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* Drug: Remifentanil 1
* Drug: Control
* Drug: Remifentanil 2


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: - Adult patients, aged 18-60 with ASA physical status I or II, who were scheduled to minor elective surgery (< 1 h) were considered for the study Exclusion Criteria: - Exclusion criteria were allergies to the study drugs, a history of gastric reflux, a history of drug abuse, obesity (body mass index > 30 kg/m2) and suspected difficult airway

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Control<br>The control group, which received an infusion of normal saline. | Drug: Control<br>* The control group, which received an infusion of normal saline<br>* Other names: Placebo;|
| Active Comparator: Remifentanil 1<br>Remifentanil 1: The R1 group, which received a target effect-site remifentanil concentration of 1 ng/ml. | Drug: Remifentanil 1<br>* Remifentanil 1: The R1 group, which received a target effect-site remifentanil concentration of 1 ng/ml.<br>* Other names: R1;|
| Active Comparator: Remifentanil 2<br>Remifentanil 2: The R2 group, which received a target effect-site remifentanil concentration of 2 ng/ml. | Drug: Remifentanil 2<br>* Remifentanil 2: The R2group, which received a target effect-site remifentanil concentration of 2 ng/ml.<br>* Other names: R2;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| LMA Insertion Condition | The pre-determined effect-site concentration of remifentanil or normal saline was administered according to the patient's group.LMAs were size #3 for women and #4 for men.The conditions of the LMA insertion were graded on a three point scale using six variables (mouth opening, ease of LMA insertion, swallowing, coughing and gagging, head and body movements, laryngospasm). Each of these variables was rated as excellent, intermediate or poor. | at that time on LMA insertion only | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Frequency of Apnea | If prolonged apnoea (> 30 s) developed, manual ventilation was assisted. And record the frequency of apnea on each group | baseline, 30sec after drug injection | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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laryngeal mask airway, insertion, sevoflurane, remifentanil