linjc16/ctgov huggingface dataset:
Spatio-temporal Parameters of Walking in Patients Hospitalized in Acute Geriatrics

Study Overview
=================
Brief Summary
-----------------
The prevalence of walking disorders in the elderly is high. These can lead to falls which represent a major public health issue in terms of hospitalization, morbidity and cost. Numerous studies analyzing the link between spatio-temporal parameters of gait and fall have already been carried out, but most have been carried out in a population of elderly patients living at home and having no or few comorbidities. Very few studies have been carried out in a population of frail elderly people, with multiple comorbidities or multiple medication, which is the case with most patients hospitalized in acute geriatrics. The objective of the study is to evaluate the spatio-temporal parameters of walking using the GAITRite® mat in patients hospitalized in acute geriatrics and to compare them between a population of falling patients and a population of patients. no faller.

Official Title
-----------------
Spatio-temporal Parameters of Walking in Patients Hospitalized in Acute Geriatrics: Comparison of a Population of Fallers and Non-fallers

Conditions
-----------------
Difficulty Walking

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: Subject aged > 70 years Have been hospitalized in an acute geriatric ward at the University Hospitals of Strasbourg between 01/06/2019 and 28/02/2020 Have been able to walk on a square surface at least 12 meters long, with or without technical assistance Subject not having expressed, after being informed, his opposition to the reuse of his medical data for scientific research purposes. Exclusion criteria: Subject having expressed opposition to participating in the study Non-autonomous subject for transfers and trips Subject under guardianship, curatorship or safeguard of justice

Ages Eligible for Study
-----------------
Minimum Age: 71 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Study of the spatio-temporal parameters of walking using the GAITRite® mat in patients hospitalized in acute geriatrics and to compare them between a population of falling patients and a population of patients. no faller. |  | Files analysed retrospectively from June 1, 2019 to February 28, 2020 will be examined] | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Difficulty Walking, Elderly person, Spatio-temporal parameters
DyeVert Pilot Trial

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate the usability characteristics of DyeVert™ during normal clinical use and to understand the amount of contrast media (CM) diverted from the subject and saved over a total angiographic procedure.

Official Title
-----------------
DyeVert Pilot Trial

Conditions
-----------------
Coronary Angiography

Intervention / Treatment
-----------------
* Device: Coronary Angiography


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: The subject is indicated for a coronary angiogram or percutaneous coronary procedure The subject is ≥ 18 years of age The subject (or subject's legal representative) is willing and able to provide appropriate informed consent. Exclusion Criteria: Subject is undergoing a STEMI procedure The subject is female and currently pregnant In the investigator's opinion, the subject is not considered to be a suitable candidate

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Treatment Arm<br>All subjects enrolled in the trial will use the DyeVert System. | Device: Coronary Angiography<br>* The DyeVert System will be used during coronary angiographic procedures which include: diagnostic only, diagnostic + PCI or PCI only cases.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Volume (Percentage) of Contrast Media (CM) Diverted (Saved) in a Total Procedure | The subject is exited from the study once they are discharged. | 1 Day |
Evaluation by MRI of Anal Canal Cell Carcinoma: is There Predictive Factor?

Study Overview
=================
Brief Summary
-----------------
Anal canal cell carcinoma is a very rare cancer but well treated. If the morphological test are well established in the initial evaluation, it's not the case of the follow up evaluation particularly by MRI.About 1/3 of patient decline with metastatic relapse during the follow up of these patients.It appears that clinical regression seen precociously is a predictive factor of survival without relapse. But there 's no study confirming that point. This context takes us to evaluate if there is a predictive factor in MRI to final clinical result.

Official Title
-----------------
Evaluation by MRI of Anal Canal Cell Carcinoma: is There Predictive Factor?

Conditions
-----------------
Anal Carcinoma

Intervention / Treatment
-----------------
* Diagnostic Test: MRI sequence


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patient with anal canal cell carcinoma histologically proved patient with initial MRI and follow up MRI in Hospital St Joseph's radiology yard. patient for whom a radio chemotherapy treatment decision was taken. Exclusion Criteria: patients with already metastatic lesions

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: MRI sequence|several MRI sequence before and after contrast product injection.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Distance with regard to the anal margin | tumor position | maximum of 6 years after the initial MRI | 
| initial tumor size | Maximal tumoral size in the cranio-caudal plan in cm | maximum of 6 years after the initial MRI | 
| presence of nodal status | presence of nodal status in inguinal region | maximum of 6 years after the initial MRI |
Characterization of the Microbiome in Peritoneum, Jejunum, Rectum and Stool

Study Overview
=================
Brief Summary
-----------------
Characterization of the human microbiome in the jejunum and comparison to the microbiome in the rectum and stool in order to see how the microbial communities change within the intestines.

Detailed Description
-----------------
Subjects to undergo surgery with opening of the jejunum will be sampled with sterile swabs from peritoneum and the inside of the jejunum. A swab will also be taken from the rectum. The peritoneum is regarded as a sterile place until today. We try to either verify this, we also could find a scientific base for theories like leaky gut or other forms of bacterial migration through the intestinal wall. Many of these patients undergo bariatric surgery. Many of them do have a dramatic change in glucose metabolism immediate after surgery. Therefore stool swabs will be taken before and 5 days after surgery.

Official Title
-----------------
Characterization and Comparison of the Human Microbiome in Peritoneum, Jejunum, Rectum and Stool

Conditions
-----------------
Obesity, Diabetes Mellitus, Fatty Liver, Nonalcoholic, Leaky Gut Syndrome, Chronic Pancreatitis

Intervention / Treatment
-----------------
* Diagnostic Test: Microbial Swab


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: abdominal surgery containing opening of jejunum singing of consent Exclusion Criteria: inflammative condition (appendicitis, pancreatitis, Crohn, Colitis ulcerous, cholecystitis and similar)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients<br>Subjects to undergo surgery including opening of the jejunum with non-inflammative condition. | Diagnostic Test: Microbial Swab<br>* Swabs will be taken from peritoneum and jejunum (intraoperatively), rectum, and stool<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Characterization of microbiome | Previously uncharacterized sites: jejunum, peritoneum | intra-operative | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Microbiome, Obesity, Chronic Liver Disease
Validity and Reliability of Turkish Version of The Working Memory Questionnaire

Study Overview
=================
Brief Summary
-----------------
The aim of this study was to determine the Turkish validity and reliability of ''The Working Memory Questionnaire'' developed by Dr. Vallat-Azouvi.

Detailed Description
-----------------
Working Memory refers to the temporary storage and exchange of information required for complex tasks such as language, understanding, learning, and reasoning. Working memory deficits are worse in people with advanced age and low education. In addition, working memory is impaired in children with traumatic brain injury, stroke, Alzheimer's disease, and attention deficit hyperactivity disorder. The aim of this study is to determine the Turkish version, validity, and reliability of ''The Working Memory Questionnaire''. 300 health people will include in the study. In order to determine the reliability of the scale, the intraclass correlation coefficient (ICC) will be used to determine the level of the relationship between the results of the first and second measurements. Cronbach's alpha coefficient will be used for the homogeneity of the questions in the scale. For construct validity, the correlation coefficient will be used to determine the agreement between the Turkish Version of Cognitive Failures Questionnaire and The Working Memory Questionnaire.

Official Title
-----------------
Validity and Reliability of Turkish Version of The Working Memory Questionnaire

Conditions
-----------------
Working Memory, The Working Memory Questionnaire

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Being an individual between the ages of 18-50 Exclusion Criteria: Having a neurological and mental illness

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The Working Memory Questionnaire | The Working Memory Questionnaire has been designed by Dr. Vallat-Azouvi at el. specifically to assess everyday life difficulties related to working memory failures. It consists of 30 statements rated on a 5-point Likert-type scale ranging from not at all to extremely. WMQ is consists of 3 subscales, there are storage, attention, and executive domains.The total score ranges from 0-120 points. Higher scores correspond to more self-identified difficulties | 15 minute | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Turkish Version Cognitive Failures Questionnaire | The Cognitive Failures Questionnaire (CFQ) is a self-report questionnaire to assess failures of perception, motor function, and memory. CFQ is consists of 25 items and 5 points Likert-type scale. The total score is ranges from 0-100 points. | 12 minute |
Almonertinib Plus Metronomic Oral Vinorelbine

Study Overview
=================
Brief Summary
-----------------
To evaluate the efficacy of continuing osimertinib in conjunction with metronomic oral vinorelbine after limited progression on osimertinib, to provide clinical experience on the treatment strategy for these patients.

Detailed Description
-----------------
This study is a clinical observation study. The patients who comfirm the criteria will be treated with Almonertinib plus metronomic oral vinorelbine. The patients will be followed up until the tumor progressed, and the efficacy (PFS, ORR, DCR) of tumor therapy were evaluated. Drug administration regimen: Ametinib 110mg once a day; Oral Vinorelbine 40mg three times a week for three weeks and Q28d for one course.

Official Title
-----------------
Almonertinib Plus Metronomic Oral Vinorelbine Beyond Limited Progression on Third-generation TKI in EGFR-mutant Advanced NSCLC，an Observational Study

Conditions
-----------------
EGFR, NSCLC, Third-generation TKI

Intervention / Treatment
-----------------
* Drug: Almonertinib and metronomic oral vinorelbine


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Non-small cell lung cancer diagnosed by histopathology or cytology; Previous molecular pathology was EGFR sensitive mutation; Stage IV; ECOG score 0-2; Prior to receiving the third generation of EGFR-TKI targeted therapy, and TKI targeted therapy showed limited progress; According to RECIST1.1 standards, there are measurable or evaluable lesions The patient has fully understood this study and voluntarily signed a written informed consent form; The estimated survival time is more than 3 months. Exclusion Criteria: Histological or cytological confirmation of small cell lung cancer or squamous cell carcinoma at the first diagnosis; The progression of the third generation EGFR-TKI suggests histological transformation.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Study arm<br>Almonertinib plus metronomic oral vinorelbine | Drug: Almonertinib and metronomic oral vinorelbine<br>* Ametinib 110mg once a day; Oral Vinorelbine 40mg three times a week for three weeks and Q28d for one course.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| PFS | progression-free survival | From date of randomization until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 100 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| ORR | Objective Response Rate | up to 12 months | 
| DCR | Disease Control Rate | up to 12 months |
Prevalence of Vertebral Fractures in HIV Infected Patients Older Than 50 Years

Study Overview
=================
Brief Summary
-----------------
Prospective cohort study to determine the prevalence of vertebral fractures in HIV infected patients older than 50 years.

Detailed Description
-----------------
To determine the prevalence of asymptomatic vertebral fractures in HIV patients older than 50 years, and the risk of fracture during a follow up of 2 years, according to bone mineral density at inclusion, the level of serum bone biomarkers, and the presence of secondary factors such as hypovitaminosis D or/and secondary hyperparathyroidism.

Official Title
-----------------
Prevalence of Vertebral Fractures in HIV Infected Patients Older Than 50 Years: Importance of Bone Mineral Density and Bone Biomarkers

Conditions
-----------------
Vertebral Fractures

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age above 50 years HIV infection Exclusion Criteria: Pregnancy Receiving corticosteroids or antiresorptive therapy

Ages Eligible for Study
-----------------
Minimum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| HIV patients older than 50 years<br>HIV infected patients older than 50 years in current follow up | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prevalence of vertebral fractures in HIV patients older than 50 years | To determine by lumbar and thoracic x ray the presence of vertebral fractures and the changes in vertebral form or size, according to Genant methods | 2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Risk of vertebral alteration according to bone mineral density and serum biomarkers | To determine the relationships of vertebral alterations with bone mineral density by dual X-ray absorptiometry | 2 years | 
| Vertebral alterations during follow up | To determine the emergence of vertebral alterations during 2 years of follow up according to bone mineral density, bone biomarkers (osteocalcin, beta-crosslaps), and vitamin D/parathyroid hormone (PTH) status. | 2 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
HIV, bone, fractures, vitamin D, biomarkers
Mohs Micrographic Surgery and Reconstruction in the Optum Insurance Claims Database

Study Overview
=================
Brief Summary
-----------------
Mohs micrographic surgery (MMS) followed by skin reconstruction has been widely accepted for treatment of many skin cancers. To further characterize the trends in MMS and reconstruction for skin cancer, a retrospective analysis will be performed using the Optum© Clinformatics® DataMart de-identified commercial claims database from 2001-2016. The findings may provide critical data for future prospective studies in skin cancer treatments.

Official Title
-----------------
Characterizing Trends in Mohs Micrographic Surgery and Complex Reconstruction in the Optum Healthcare Population

Conditions
-----------------
Skin Cancer, Mohs Micrographic Surgery, Interpolated Flap Repair

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: - All patients in the Optum© Clinformatics® database who have an ICD9 or ICD10 code for skin cancer and a corresponding CPT code specific for interpolated flap reconstruction Exclusion criteria: - All patients for whom cost data is missing in the Optum© Clinformatics® DataMart

Ages Eligible for Study
-----------------
Minimum Age: 1 Year
Maximum Age: 99 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cohort 1<br>Patients from the existing Optum insurance claimed database with a confirmed diagnosis of melanoma, basal cell carcinoma, or squamous cell carcinoma who have undergone skin cancer excision surgery followed by interpolated flap repair between the years 2001-2006. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Primary cost | How does interpolation flap procedure cost differ across settings | Claims from 2001-2016 will be analyzed | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Predictors of inpatient vs. outpatient procedure | How does medical specialty or geographical location predict where the procedure is performed | Claims from 2001-2016 will be analzyed |
Frenotomy of the Labial Frenulum in Infants With Breastfeeding Difficulties

Study Overview
=================
Brief Summary
-----------------
Upper lingual frenulum have been implicated as a cause for pain during breastfeeding and latch problems. The investigators hypothesize that performing frenotomy of the frenulum may improve breastfeeding. The investigators will include breastfeeding infants with pain or latch problems in whom the lingual frenulum had been treated but breastfeeding problems were not resolved. The investigators plan to study the effect of frenotomy of the upper lingual frenulum on maternal pain (using pain score by visual analog scale) and/or latch score.

Official Title
-----------------
Effect of Labial Frenulum Clipping on Nipple Pain and Latch Problems in Breastfeeding Infants

Conditions
-----------------
Breastfeeding

Intervention / Treatment
-----------------
* Procedure: Lingual Frenulum frenotomy
* Procedure: Sham frenotomy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: breastfeeding infants maternal nipple pain latching problems Exclusion Criteria: oral cavity anomalies breast anatomical anomalies untreated tongue-tie in infant

Ages Eligible for Study
-----------------
Maximum Age: 6 Months

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Frenotomy<br> | Procedure: Lingual Frenulum frenotomy<br>* Clipping the lingual frenulum with scissors<br>|
| Sham Comparator: Sham Frenotomy<br> | Procedure: Sham frenotomy<br>* Sham Clipping the lingual frenulum with scissors<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain score by Visual Analog Scale |  | Within 30 minutes | 
| Latch Score |  | Within 30 Minutes | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Breastfeeding difficulties, lingual frenulum, labial frenulum, frenotomy