Effects of Propofol and Ketofol on Core Body Temperature in MRI

Study Overview
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Brief Summary
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Investigators researched the effect of two different types of drugs on core body temperature during magnetic resonance imaging. The hypothesis is in ketamine group, thermo disregulation is not as distinct as in propofol group, due to its positive effect on thermo regulation

Detailed Description
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Intravenous anesthetics may impair thermoregulation. Absorption of radiofrequency waves by the body surface may result in heating, especially in small children during magnetic resonance imaging (MRI). Investigators applied two different intravenous anesthetics as propofol and ketamine and studied the effect of these drugs on core body temperature. All patients aged between 6 months-10 years were administered midazolam and atropine. After that 1 mg/ kg of propofol was applied in group I, and 0,1 ml/kg of propofol ketamine mixture ( 10 mg/ml each) was applied in group II. Core body temperatures were taken before and after MRI and compared.

Official Title
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Does Magnetic Resonance Imaging Increase Core Body Temperature in Anesthetized Children? Evaluating the Effects of Propofol and Ketofol

Conditions
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Children

Intervention / Treatment
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* Drug: propofol
* Drug: Ketamine propofol mixture


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: children aged between 6 months-10 years, underwent MRI under anesthesia ASA I-II Exclusion Criteria: History of drug allergy Severe pulmonary and cardiac disease Intracranial hypertension

Ages Eligible for Study
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Minimum Age: 6 Months
Maximum Age: 10 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: propofol<br>body core temperature was measured from tympanic membrane after 1 mg/kg propofol administration, before and after magnetic resonance imaging | Drug: propofol<br>* propofol, midazolam and atropine administration via intravenous cannula.<br>* Other names: propofol 1%;Drug: Ketamine propofol mixture<br>* Administration of ketamine propofol mixture, midazolam and atropine via intravenous cannula<br>* Other names: ketofol;|
| Active Comparator: ketofol<br>body core temperature was measured from tympanic membrane after 0,1 ml/kg administration of ketamine propofol mixture of 10 mg/ml both, before and after magnetic resonance imaging | Drug: propofol<br>* propofol, midazolam and atropine administration via intravenous cannula.<br>* Other names: propofol 1%;Drug: Ketamine propofol mixture<br>* Administration of ketamine propofol mixture, midazolam and atropine via intravenous cannula<br>* Other names: ketofol;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in core body temperature | temperature was taken from tympanic membrane bilaterally before and after MRI. If temperature change was more or les than 0.1 degrees celsius the patient was considered as warmer or cooler. | during magnetic resonance imaging (MRI) procedure | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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core body temperature, magnetic resonance imaging, propofol, ketofol