Evaluation of Ocular Biometry in PACD With Two Swept Source Optical Coherence Tomography Devices

Study Overview
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Brief Summary
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Purpose: To investigate agreement between 2 swept source OCT biometers, IOL M.aster700 and Anterion, in various ocular biometry and intraocular lens (IOL) calculations of primary angle-closure disease (PACD). Methods: This was a prospective study conducted in a tertiary eye care centre involving biometric measurements obtained with 2 devices in phakic eye with diagnosis of PACD. Mean difference and intraclass correlation coefficient (ICC) with confidence limits were assessed, and calculations of estimated residual refraction of the IOL were analysed using Barrett's formula.

Detailed Description
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Primary angle-closure disease (PACD) is the leading cause of blindness worldwide. PACD is an anatomic disorder, typically of relatively small eye with shallow anterior chamber depth (ACD), thick lens, shorter axial length (AL), small corneal curvature, and relatively anterior lens position. Pupillary block, plateau iris and phacomorphic mechanisms play major roles in the pathophysiology of the disease, and pupillary block is thought to be the most common causal mechanism. For decades, phacoemulsification and intraocular lens implantation (PEI) has been proposed for initial management of PACD.4 PEI relieves pupillary block, deepening ACD and widening irido-corneal angle. Biometry is essential in evaluating ocular dimensions and calculating IOL power in PACD, and ocular biometers have been evolving in recent years. Optical coherence tomography (OCT) includes partial coherence interferometry (PCI), and swept source OCT (SS-OCT) is in general use in clinical practice. The agreement of the calculations of these devices has been studied by many investigators; however, research into their agreement in PACD patients has been sparse so far. A newer SS-OCT, Anterion, is now available and its performance needs to be evaluated.

Official Title
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Evaluation of Ocular Biometry in Primary Angle-closure Disease With Two Swept Source Optical Coherence Tomography Devices

Conditions
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Primary Angle Closure Glaucoma

Intervention / Treatment
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* Diagnostic Test: primary angle closure disease


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Inclusion criteria were age > 40 years old phakic eye diagnosis of PACD, including primary angle-closure suspect (PACS), primary angle-closure (PAC) and primary angle-closure glaucoma (PACG) as classified by Foster et al Exclusion Criteria: patients who had opaque optical media dense cataract anterior and/or posterior segment diseases such as advanced pterygium, diabetic retinopathy, or maculopathy Participants who had previous history of ocular trauma, ocular surgery

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 77 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| one group compared two measurement methods<br>one group compared two measurement methods | Diagnostic Test: primary angle closure disease<br>* 2 swept source OCT biometers, IOL Master700 and Anterion<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Intraclass correlation coefficient of IOL power calculation | agreement between 2 swept source OCT biometers, IOL Master700 and Anterion, in intraocular lens (IOL) calculations | 30 minutes per person | 
| Intraclass correlation coefficient of various ocular biometry | agreement between 2 swept source OCT biometers, IOL Master700 and Anterion, in various ocular biometry( ACD, AL, LT, K1, K2, WTW) | 30 minutes per person | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Ocular biometry, swept source OCT, agreement