Effect of Low Tidal Volume on Blood Loss During Laparoscopic Hepatectomy

Study Overview
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Brief Summary
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To explore the effect of low tidal volume on blood loss and gas exchange during laparoscopic hepatectomy

Detailed Description
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Background & Aims:Liver cancer is an disease that threatening human health .Laparoscopic hepatectomy is more and more widely used.It is very important to reduce the bleeding during laparoscopic hepatectomy.The investigators found that low tidal volume can effectively reduce intraoperative bleeding.The aim of this study was to explore the effect of low tidal volume on blood loss and gas exchange during laparoscopic hepatectomy

Official Title
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Effect of Low Tidal Volume on Blood Loss During Laparoscopic Hepatectomy

Conditions
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Blood Loss

Intervention / Treatment
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* Other: Tidal volume


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Aged from 18 to 70 years old; American association of anesthesiologists(ASA) score I to III; Ability to adhere to the study schedule; Ability to provide informed consent and complete all study assessments; Patients undergoing selective surgery of laparoscopic hepatectomy. Exclusion Criteria: The New York Heart Association classification(NYHA) III to IV; Chronic obstructive pulmonary disease,respiratory failure, patients after thoracic surgery. BMI>32Kg/m2; Abnormal in blood coagulation function; Patients with mental disease; Patients with neuromuscular disease; Concurrent enrollment in another Randomized controlled trial(RCT); Absence of written informed consent.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Two different tidal volume are conducted on the participant base on the randomized choices
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Low tidal volume group<br>Use a low tidal volume(6'8ml/kg) ventilation mode during liver segmentation。 | Other: Tidal volume<br>* After General anesthesia, patients that during volume control mode of mechanical ventilation in experimental group, we take low tidal volume.<br>|
| Active Comparator: Standard tidal volume group<br>Use a standard tidal volume(10'12ml/kg) ventilation mode during operation. | Other: Tidal volume<br>* After General anesthesia, patients that during volume control mode of mechanical ventilation in experimental group, we take low tidal volume.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood loss | Blood loss during operation. | through study completion, an average of 48hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| central venous pressure | The central venous pressure(CVP)during operation | During operation | 
| mean arterial pressure | The mean arterial pressure(MAP)during operation | During operation | 
| oxygenation index | The oxygenation index during operation. | During operation | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Laparoscopic hepatectomy, Low tidal volume, Blood loss