Trichoscopy and Systemic Scleroderma

Study Overview
=================
Brief Summary
-----------------
Few data are available on scalp involvement in systemic scleroderma. Few data are available on the association between scalp abnormalities and features of systemic scleroderma Trichoscopy is a simple, reproducible, noninvasive examination that is part of the examination of hairy areas in routine dermatologic practice There is a lack of simple, noninvasive examinations to evaluate patients with systemic scleroderma The objective will be to evaluate the contribution of trichoscopy in the evaluation of patients with systemic scleroderma

Official Title
-----------------
Prognostic Value of Trichoscopy in Patients With Systemic Scleroderma

Conditions
-----------------
Scleroderma, Systemic

Intervention / Treatment
-----------------
* Procedure: picture


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patient who fulfils the Systemic scleroderma ACR-EULAR 2013 criteria Signed informed consent Being social insured Exclusion Criteria: Patients aged less than 18 years old patients under legal protection patients deprived of their liberty patients in emergency situations patients who refused or unable to give informed consent For the control group: sclap inflammatory disease active the day of the examination

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| patients with systemic scleroderma<br> | Procedure: picture<br>* We will perform a non-invasive assessment of the scalp with a dermoscope by taking two standardized pictures on the frontal area and the occipital area in order to a blinded analysis of trichoscopic patterns<br>* Other names: Non-invasive trichoscopy: dermoscopic assessment of the scalp (picture);|
| healthy subject<br>healthy subject without systemic scleroderma or known hair or scalp disease | Procedure: picture<br>* We will perform a non-invasive assessment of the scalp with a dermoscope by taking two standardized pictures on the frontal area and the occipital area in order to a blinded analysis of trichoscopic patterns<br>* Other names: Non-invasive trichoscopy: dermoscopic assessment of the scalp (picture);|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Frequency of elementary lesions observed by trichoscopic assessment of the scalp | Comparison of the frequencies of elementary lesions visualized in patients with systemic scleroderma and healthy subjects | Baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between visceral damage of systemic scleroderma and trichoscopic features | Frequency of visceral damage of systemic scleroderma: pulmonary hypertension, lung fibrosis, kidney failure. | Baseline | 
| Correlation between global severity of systemic scleroderma and trichoscopic features | Correlation between EUSTAR score, Rodnan score, Medsger's score and trichoscopic features | Baseline | 
| Correlation between autoimmune profile of sclerodermic patients and trichoscopic features | Correlation of antibodies, inflammatory profile of patients with trichoscopic features. | Baseline | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Trichoscopy, Dermoscopy, Systemic Scleroderma, Scalp