Screening Intracranial Aneurysms With Magnetic Resonance Angiography (MRA) in China

Study Overview
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Brief Summary
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The Chinese Cerebral Aneurysms Survey is a continuing prospective study among middle-aged and older individuals (35 - 75 years) that aims to determine the prevalence of cerebral intracranial aneurysms in the general population with MRA at 3.0 Tesla (T).

Detailed Description
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Cerebral intracranial aneurysms are common. In angiographic and autopsy studies, estimates for prevalence vary between 0.2 and 9.9 percent. The methods used to detect the aneurysms markedly influenced the proportion of aneurysms. Retrospective autopsy studies probably give an underestimation and prospective angiography studies an overestimation of the actual prevalence. Accurate data on the prevalence of intracranial aneurysms are essential in evaluating the results of screening programs for aneurysms in general population. During the past decade, MRA, as a preferred accuracy modality for noninvasive intracranial vascular imaging at most centers, is playing an increasing role in the evaluation of patients suspected of having intracranial aneurysms. In recurrent study, we have tested that MRA at 3T has excellent sensitivity, accuracy, and correlation with DSA and is comparable to catheter cerebral angiography for the evaluation of patients with intracranial aneurysms (Stroke, in press). Therefore, we examined trends in intracranial aneurysm prevalence with the use of MRA at 3.0T to determine the true prevalence of cerebral intracranial aneurysms in the general middle-aged or elder population.

Official Title
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Epidemiology of Cerebral Aneurysms With MRA in China in Middle-aged or Elder Person: a Population-based Survey

Conditions
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Intracranial Aneurysm

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Native inhabitants lived in a defined area sites in China Aged 35-75 years Exclusion Criteria: Less than 35 years old or more than 75 years old Incompetent patient who cannot give consent for routine MR Angiography and his/her surrogate decision maker is not available Any patients with a contraindication to having a standard MRI examination, such as phase maker, orbital metallic foreign body, etc.

Ages Eligible for Study
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Minimum Age: 35 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cerebral intracranial aneurysms identified by 3-D TOF-MRA at 3T |  | 18 months after the study | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Suspected cerebral aneurysms detected by MRA underwent digital subtraction angiography (DSA) examination |  | 32-36 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Magnetic resonance angiography, Intracranial aneurysm, cerebral aneurysm, unruptured aneurysm, Epidemiology, Magnetic Resonance Imaging