linjc16/ctgov huggingface dataset:
Venous Distension in Patients With Aneurysmatic Arterial Disease

Study Overview
=================
Brief Summary
-----------------
The aim of the study is to assess if venous distension in patients with aneurysmatic arteriopathy is higher compared to patients with peripheral arterial occlusive disease (PAOD) and in controls.

Detailed Description
-----------------
Patients with aortic aneurysm and patients with PAOD and Controls will be investigated in the following manner: Duplexsonography with assessment of the arterial diameters in the aorta and leg arteries. Duplexsonography with assessment of venous reflux in proximal and deep veins of both legs Duplexsonography testing of venous distension in the common femoral vein, the great saphenous vein and the femoral vein.

Official Title
-----------------
Venous Distension in Patients With Aneurysmatic Arterial Disease Compared to the Venous Distension in Patients With Arterial Occlusive Disease

Conditions
-----------------
Aortic Aneurysm, Abdominal, Popliteal Artery Aneurysm, Peripheral Arterial Occlusive Disease, Vascular Diseases, Aortic Diseases, Varicose Veins

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with dilatative arteriopathy (DA) the aortic diameter must be > 3 cm or the popliteal artery diameter > 1.5 cm Patients with arterial occlusive disease (PAOD) defined with an Ankle brachial index (ABI) < 0.9 and positive criteria in the Edinburgh questionnaire Patients able to give informed consent Control group of age matched persons without PAOD (ABI > 0.9) and without DA Exclusion Criteria: Impossibility to stand Diabetes No given informed consent Persons and patients < 18 years old Acute deep venous thrombosis History of deep venous thrombosis

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Aneurysmatic disease<br>Patients with dilatative arteriopathy (DA) the aortic diameter must be > 3 cm or the popliteal artery diameter > 1.5 cm | |
| Peripheral arterial occlusive disease<br>Patients with arterial occlusive disease (PAOD) defined with an Ankle brachial index (ABI) < 0.9 and positive criteria in the Edinburgh questionnaire. | |
| Healthy<br>Control group of age matched persons without PAOD (ABI > 0.9) and without DA. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Venous distension of > 27% in patients with aneurysmatic arterial disease |  | one year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
venous distension, venous reflux
is Ultrasound-guided Foam Sclerotherapy a Cost-effective Alternate for Treatment of Varicose Veins?

Study Overview
=================
Brief Summary
-----------------
. It is the aim of this paper is to discuss our experience of foam sclerotherapy for varicose veins atour hospital

Detailed Description
-----------------
we will manage all patients with vericose veins with injection sclerotherapy and will monitor there response in terms of relive in vsisble veins, swelling and pain. we also want to evaluate hoe many sessions of injection sclerotherapy are required for complete resolution of symptoms.

Official Title
-----------------
is Ultrasound-guided Foam Sclerotherapy a Cost-effective Alternate for Treatment of Varicose Veins?

Conditions
-----------------
Pain, Leg Edema, Cost Effectiveness, Cosmesis

Intervention / Treatment
-----------------
* Drug: Sodium Tetradecyl Sulfate


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All the patients who present with symptomatic varicose veins underwent a duplex scan by radiologist to identify site of reflux and condition of deep veins. If the patient is a candidate for intervention then he is offered surgery or foam sclerotherapy Exclusion Criteria: recurrent and secondary varicose veins

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: INTERVENTION GROUP<br>SINGLE ARM OF PATIENTS WHO WILL RECEIVE SAME TREATMENT | Drug: Sodium Tetradecyl Sulfate<br>* DRUG WILL BE INJECTED TO ALLAPTIENTS ACCORDING TO STANDARD PROTOCOL<br>* Other names: STS;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| pain by VAS score | pain by VAS score | 1 MONTH | 
| leg edema | leg edema | 1 MONTH | 
| cosmesis | cosmesis | 1 MONTH | 
| cost effectiveness | cost effectiveness | 1 MONTH |
Tissue-of-origin Directing Therapy in Patients With Cancer of Unknown Primary

Study Overview
=================
Brief Summary
-----------------
This study is designed to evaluate the value of tissue-of-origin (ORIGIN-PanCA○R) profiling in predicting primary site and directing therapy in patients with cancer of unknown primary.

Official Title
-----------------
The Value of Tissue-of-origin (ORIGIN-PanCA○R) Profiling in Predicting Primary Site and Directing Therapy in Patients With Cancer of Unknown Primary: a Prospective Randomized Controlled Study

Conditions
-----------------
Cancer of Unknown Primary Site

Intervention / Treatment
-----------------
* Genetic: tissue-of-origin (ORIGIN-PanCA○R) profiling


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: had a diagnosis of cancer of unknown primary (CUP) after a standard evaluation (medical history, physical examination, blood counts, chemistry profile, chest/abdomen computed tomography scans, positron emission tomography scan, and directed evaluation of all symptomatic areas). Patients were required to have one of the following histologies: adenocarcinoma, poorly differentiated neoplasms, poorly differentiated carcinoma, squamous carcinoma. Sufficient archived biopsy tissue from a surgical or core needle biopsy was required to perform the molecular profiling assay. Eastern Cooperative Oncology Group performance status of 0 to 2; no previous systemic therapy; measurable or evaluable disease (RECIST); and adequate organ function. Exclusion Criteria: carcinoma limited to single site which can be potentially cured by surgery of radiotherapy.patients with symptomatic brain metastases, active clinical severe infection

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Tissue-of-origin test
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: site-specific therapy<br>standard treatments of sites of origin | Genetic: tissue-of-origin (ORIGIN-PanCA○R) profiling<br>* 90-gene assay to predict the primary tumor site<br>|
| Active Comparator: standard empiric chemotherapy<br>standard empiric chemotherapy | Genetic: tissue-of-origin (ORIGIN-PanCA○R) profiling<br>* 90-gene assay to predict the primary tumor site<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| progression free survival |  | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| overall response rate |  | 2 months | 
| overall survival |  | 12 months | 
| Adverse Events |  | 2 months | 
| biomarker analysis |  | 6 months |
Validity and Reliability in Measuring Biceps and Triceps by Using Ultrasound

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to estimate the validity and reliability in the measurement of bicep and tricep tendons and muscular morphologic characteristics by using ultrasound.

Official Title
-----------------
Validity and Reliability in Measuring Tendon and Muscular Morphologic Characteristics of Biceps and Triceps by Using Ultrasound

Conditions
-----------------
Healthy

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy male subjects Age range from 19-35 years Exclusion Criteria: History of shoulder or elbow pain which needs medical treatment or surgery

Ages Eligible for Study
-----------------
Minimum Age: 19 Years
Maximum Age: 35 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
muscle, tendon
Study of Reserves After Traumatic Brain Injury

Study Overview
=================
Brief Summary
-----------------
It is hypothesized that the long-term results of rehabilitation and subsequent aging after Brain Trauma depend on brain's premorbid anatomical (structural) and functional (cognitive, emotional) reserves. The purpose of this study are: to determine whether such reserves exist. to study their convergent and discriminant validity. to study their characteristics.

Official Title
-----------------
Study of Reserves After Traumatic Brain Injury:Influence of Brain, Cognitive, and Emotional Reserves on Long-Term Consequences of Traumatic Brain Injury

Conditions
-----------------
Traumatic Brain Injury

Intervention / Treatment
-----------------
* Device: Brain MRI
* Device: MRI


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Moderate-Severe Traumatic Brain Injury according to at least 1 the following: Duration of loss of consciousness (LOC) - more then 1/2 hour Glasgow Coma Scale (GCS) - less then 13 Post Traumatic Amnesia (PTA) - more then 24 hours. At least 1 year after the injury. Exclusion Criteria: Mild Traumatic Brain Injury the present state of Post Traumatic Amnesia dementia the age less than 18 years on the moment of injury less than 1 year since the injury incapacity of the patient to cooperate in the study (incapacity of any source including physical, mental, and language problems) premorbid diagnosis of Mental Retardation

Ages Eligible for Study
-----------------
Minimum Age: 19 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: healthy persons<br> | Device: Brain MRI<br>* Brain MRI<br>Device: MRI<br>* Physical examination Neuropsychological testing Questionnaires<br>|
| Experimental: patients after moderate-severe TBI<br> | Device: Brain MRI<br>* Brain MRI<br>Device: MRI<br>* Physical examination Neuropsychological testing Questionnaires<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Neuropsychological battery |  | neuropsychological baterry for every participant will be performed during 3-4 meetings. An expected average for complete neuropsychological assessment is about 8 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Traumatic Brain Injury, long-term outcome, Brain Reserves, Cognitive Reserves, Emotional Reserves, Patients 1 year or more after Moderate or Severe Traumatic Brain Injury
Closure of the Uterine Artery at Its Origin vs at the Cervix: a Randomized Trial

Study Overview
=================
Brief Summary
-----------------
One of the fundamental surgical steps in patients undergoing laparoscopic hysterectomy is the closure of the uterine artery, this vessel provides the greatest blood supply to the uterus. This step can be done in two ways: the surgeon can choose to interrupt the blood flow by closing the uterine artery in its last part, close to the uterus, or the surgeon can develop the anatomical spaces around the uterus into the deep pelvis, closing it to its origin, maintaining a minimally invasive approach in both cases. Scientific research has tried to establish whether one of the two modalities is the best in reducing intraoperative blood loss and possible complications, but currently there is not enough evidence to recommend an approach rather than another. The investigator has therefore decided to evaluate the results at the end of a laparoscopic hysterectomy in a scientifically rigorous manner.

Official Title
-----------------
Closure at the Origin of the Uterine Artery vs. Closure at the Cervico-isthmic Level in Laparoscopic Hysterectomy: a Randomized Clinical Trial

Conditions
-----------------
Anatomy, Laparoscopy, Uterine Artery, Hysterectomy

Intervention / Treatment
-----------------
* Procedure: uterine artery closure


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: benign disease elective laparoscopic hysterectomy Exclusion Criteria: malignant disease emergency laparoscopic hysterectomy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: OUC<br>Origin uterine artery closure | Procedure: uterine artery closure<br>* Interruption the uterine blood flow by closing the uterine artery at its cervical-isthmic part or at its origin.<br>|
| Active Comparator: IUC<br>Cervical-isthmic uterine artery closure | Procedure: uterine artery closure<br>* Interruption the uterine blood flow by closing the uterine artery at its cervical-isthmic part or at its origin.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| estimated blood loss | ml | End of surgical procedure |
Open Label Study of Octreotide Implant in Patients With Acromegaly

Study Overview
=================
Brief Summary
-----------------
To evaluate the pharmacokinetic (PK) and pharmacodynamic (PD) response of a hydrated and non-hydrated 84 mg octreotide implant in patients with acromegaly in the first 6 weeks of treatment.

Detailed Description
-----------------
An open-label, randomized, multi-center, parallel-group, Phase I/II study conducted in 30 male and female patients with acromegaly. Eligible patients received 1 implant, either hydrated or non-hydrated, within 7 days of their Screening Visit. The octreotide implant was inserted subcutaneously in the inner aspect of their non-dominant arm under local anesthesia. Blood samples for the determination of insulin-like growth factor 1 (IGF-1), growth hormone (GH), and octreotide serum concentrations were collected at predetermined timepoints within the first 6 weeks after implantation.

Official Title
-----------------
An Open-Label Study to Evaluate the Pharmacokinetic and Pharmacodynamic Response of a Hydrated and Non-Hydrated 84mg Octreotide Implant in Patients With Acromegaly

Conditions
-----------------
Acromegaly

Intervention / Treatment
-----------------
* Drug: octreotide acetate


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Male and female patients with acromegaly Must be at least 18 years old Confirmed diagnosis of a growth hormone -secreting tumor Must be either a full or partial responder to octreotide demonstrated by historical laboratory values Exclusion Criteria: Women who are pregnant, lactating or of child-bearing potential who are not practicing a medically acceptable method of birth control Patients with liver disease Patients with symptomatic cholelithiasis Patients receiving radiotherapy for their pituitary tumor at any time before Screening

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: One hydrated 84mg Octreotide implant<br>hydrated implant | Drug: octreotide acetate<br>* subcutaneous implant<br>|
| Experimental: One non-hydrated 84mg Octreotide implant<br> | Drug: octreotide acetate<br>* subcutaneous implant<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
S-LAR, Octreotide, Implant
Genetic Liability in the Brain Morphology of Attention Deficit Hyperactivity Disorder

Study Overview
=================
Brief Summary
-----------------
Attention Deficit Hyperactivity Disorder (ADHD) is a heritable psychiatric disorder with onset in childhood. Twin and adoption studies indicate that additive genetic factors explain up to 80% of the variance underlying susceptibility. The siblings of children with ADHD have a three- to fivefold increased risk of having ADHD compared to the siblings of healthy control subjects, and the risk is even greater for monozygotic twins with 50-80% concordance compared with up to 33% in dizygotic twins). As full siblings share on average 50% of their genes, even the unaffected siblings of children with ADHD would be expected to share some of the genes involved in the disorder. The neuroanatomical substrate of ADHD is becoming increasingly better defined by a growing body of evidence from imaging studies. Evidence from neuroimaging studies suggests that this disorder is associated with reductions in brain volume up to 5% in these children. In this protocol we collected MRI-scans from boys with ADHD and their unaffected siblings, as well as control subjects. In addition, cheekswabs were later collected for DNA analysis.

Official Title
-----------------
Genetic Liability in the Brain Morphology of Attention Deficit Hyperactivity Disorder

Conditions
-----------------
Attention Deficit Hyperactivity Disorder

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age 7 - 18 years. Inclusion criteria for patients DSM-IV (APA, 1994) diagnosis of ADHD (combined subtype), according to DISC interview scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form (TRF) one brother who meets the inclusion criteria for siblings Inclusion criteria for siblings no DSM-IV (APA,1994) diagnosis for ADHD or another disruptive disorder (ODD or CD), according to DISC interview no scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form (TRF) Inclusion criteria for controls no DSM-IV (APA, 1994) diagnosis, according to DISC interview no scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form (TRF) Exclusion Criteria: IQ < 70 illness of the cardiovascular, the endocrine, the pulmonal or the gastrointestinal system the presence of metal objects in or around the body (pacemaker, dental braces)

Ages Eligible for Study
-----------------
Minimum Age: 7 Years
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
ADHD; MRI; genetics
Apicoectomy Longterm Results

Study Overview
=================
Brief Summary
-----------------
The purpose of the study is to evaluate the longterm treatment results after micro-surgical root resection of teeth with post and core and crown.

Detailed Description
-----------------
All 73 patients, who have been treated with apicoectomy on teeth with post and core and crown between the years 2004 and 2006 and who have already been followed up in 2008, will be followed up once more in 2017. The patients will have a clinical and radiologic examination. The investigators will examine if new periapical lesions, bone loss, fracture of teeth or loss of teeth exist.

Official Title
-----------------
A Prospective Study to Evaluate the Longterm Treatment Results After Micro-surgical Root Resection of Teeth With Post and Core and Crown

Conditions
-----------------
Periapical Diseases

Intervention / Treatment
-----------------
* Diagnostic Test: x-rays


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All 73 patients, who were treated with apicoectomy on teeth with post and core and crown between the years 2004 and 2006 and who have already been followed up in 2008, will be followed up once more in 2017. Exclusion Criteria: Pregnancy Patients who do not want to participate in clinical and radiological follow up.

Ages Eligible for Study
-----------------
Minimum Age: 27 Years
Maximum Age: 79 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: x-rays|To get further and actual information about periapical lesions, different x-rays will be done (panoramic radiographic, small picture ray, cone beam computed tomography). Furthermore a periodontal status will be performed.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Appearance of periapical lesions on tooth after root resection | Appearance assessed by X-ray and classified according to Molven et al. (1987) | 1 day | 
| Size of periapical lesions on tooth after root resection | Size assessed by X-ray and classified according to Molven et al. (1987) | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Vertical and horizontal bone loss on the tooth after root resection | Bone loss in mm assessed by X-ray and probing | 1 day | 
| Occurrence of tooth fractures | Number of tooth fractures assessed by X-ray | 1 day | 
| Occurrence of tooth loss | Number of tooth losses assessed by clinical and radiological evaluation | 1 day |