Magnetic Resonance Imaging in Evaluating Response to RadiationTherapy in Patients With High Grade Glioma

Study Overview
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Brief Summary
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RATIONALE: Diagnostic procedures, such as magnetic resonance imaging, may help doctors predict a patient's response to treatment and help plan the best treatment. PURPOSE: This clinical trial is studying magnetic resonance imaging in response to radiation therapy in patients with high grade glioma.

Detailed Description
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Detailed DescriptionOBJECTIVES: I. To develop a multimodality statistical model to act as a surrogate marker scheme of early changes in high grade glioma patients undergoing radiation therapy, using conventional MRI, MR diffusion tensor imaging, perfusion, permeability, and spectroscopic imaging while incorporating the radiation dose calculations delivered locally and the results of a clinical questionnaire into the model. II. To assess treatment response to tumor and normal tissue changes. OUTLINE: Patients undergo multimodality MRI imaging at baseline, weeks 1, 2, 3, 5, and 6, and then 4-6 weeks after completion of radiation therapy.

Official Title
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Multimodality Statistical Model of Early Response of High Grade Glioma to Radiation Therapy

Conditions
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Brain Tumor

Intervention / Treatment
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* Procedure: Magnetic Resonance Imaging
* Procedure: Diffusion Tensor Imaging
* Procedure: Magnetic Resonance Spectroscopic Imaging
* Procedure: Dynamic Contract-Enhanced magnetic resonance imaging
* Procedure: Diffusion-weighted magnetic resonance imaging


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients being treated for diagnosed with high grade glioma (WHO grade III or IV) at the University of Pennsylvania Medical Center who will be undergoing radiation therapy to the brain Patient or legal representative able to provide written informed consent Adult males and nonpregnant females Exclusion Criteria: Vulnerable populations as specified (including pregnant patients, prisoners, patients with pacemakers or metallic implants) Patients with renal failure Patients with any condition considered a contraindication to MRI

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: I<br>Patients undergo multimodality MRI imaging at baseline, weeks 1, 2, 3, 5, and 6 and then 4-6 weeks after completion of radiation therapy.Patients undergo MRI imaging at baseline, weeks 1, 2, 3, 5, 6 and then 6 weeks after radiation therapy. | Procedure: Magnetic Resonance Imaging<br> <br> * Other names: MRI,NMR imaging, NMRI, nuclear magnetic resonance imaging;Procedure: Diffusion Tensor Imaging<br> <br> Procedure: Magnetic Resonance Spectroscopic Imaging<br> <br> * Other names: 1H-nuclear magnetic resonance spectroscopic imaging, Proton Magnetic Resonance Spectroscopic Imaging;Procedure: Dynamic Contract-Enhanced magnetic resonance imaging<br> <br> * Other names: DCE-MRI;Procedure: Diffusion-weighted magnetic resonance imaging<br> <br> * Other names: diffusion-weighted MRI;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Early brain tumor response |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Early therapeutic-induced changes in normal surrounding brain |  |  | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Adult Brain Tumor