Relevance of the Peripheral Cholinesterase-activity on Neurocognitive Dysfunctions in Surgical Patients

Study Overview
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Brief Summary
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In this prospective, multicenter observational study the investigators capture the perioperative course of peripheral cholinesterase activity. The focus is the perioperative inflammation causing postoperative delirium. Therefore we measure the activity of Acetylcholine-Esterase and Butyrylcholine-Esterase in whole blood of adults in the perioperative context. Early postoperative delirium will be detected by Nu-DESC in the Recovery Room or the Postanaesthesia-Care-Unit. The course of the peripheral cholinesterase activity will be compared with the incidence of postoperative delirium and other clinical dysfunctions. We follow up the patients for up to five years regarding Delirum, comorbidities and mortality data.

Official Title
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Relevance of the Peripheral Cholinesterase-activity on Neurocognitive Dysfunctions in Surgical Patients

Conditions
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Postoperative Delirium

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Male and female patients with age 18 years and above scheduled for surgery with planned stay in Recovery Room or Postanesthesia-Care-Unit Offered patient information and written informed consent In-hospital stay for at least 24 hours Exclusion Criteria: Patients with known pseudocholinesterase deficiency Participation in prospective intervention studies during the study period Analphabetism Unability of German and English language use Anacusis or Hypoacusis with hearing aid device, Amaurosis Lacking willingness to save and hand out data within the study Accommodation in an institution due to an official or judicial order Coworker of the clinic (study center)

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Surgical patients<br>Adult male and female patients undergoing surgery | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative Delirium | Postoperative Delirium (measured by Nursing Delirium Screening Scale) | Participants will be followed in the sample period, an exspected average of three days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Organ Dysfunctions |  | Participants will be followed in the sample period, an exspected average of three days | 
| Concomitant medication | Concomitant medications from Anticholinergic Drug Scale (ADS) | Participants will be followed in the three postoperative days sample period | 
| Postoperative Pain | According to Numeric Rating Scale | Participants will be followed in the three postoperative days sample period | 
| Duration of Intensive Care Unit Stay |  | Participants will be followed in the sample period, an exspected average of seven days | 
| Duration of Hospital Stay |  | Participants will be followed in the sample period, an exspected average of four weeks | 
| Duration of Mechanical Ventilation |  | Participants will be followed in the sample period, an exspected average of 168 hours | 
| Readmission rate |  | Participants will be followed in the sample period, an exspected average of four weeks | 
| Hospital Treatment Data | Operation time, surgery, anaesthesia | Participations will be followed for the duration of the operation day, an exspected time average of eight hours | 
| Postoperative Mortality | Mortality (measured inhouse-mortality according to the patients´records and based on the data record according to §21 Krankenhausentgeltgesetz - (KHEntgG)) | Participants will be followed for the duration of the sample period an exspected average of five years | 
| Postoperative Delirium | Postoperative Delirium (measured by Diagnosis of Delirium according to the patients´records and based on the data record according to §21 Krankenhausentgeltgesetz -(KHEntgG)) | Participants will be followed in the sample period, an exspected average of five years | 
| Comorbidities | Comorbidities based on the data record according to §21 Krankenhausentgeltgesetz - (KHEntgG) | Participants will be followed in the sample period, an exspected average of five years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Nursing Delirium Screening Scale,, Acetylcholinesterase Activity