The Effect of Exercise on Ovarian Reserve

Study Overview
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Brief Summary
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The purpose of this study is to examine how different levels of physical activity impact the ovarian reserve during the pre-menopausal period

Detailed Description
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Two groups are included: The study group: women between 20-35 years of age who practice high level of physical activity, as defined by International Physical Activity Questionnaire , for the past 3 years The control group: women between 20-35 years of age who practice low level of physical activity, as defined by International Physical Activity Questionnaire , for the past 3 years Women who meet the criteria for inclusion for will be recruited to the study after signing a consent form. Recruitment will be done through sport centers. The control group will include women being examined in gynecologic emergency department, after signing a consent form, if they meet the control group's inclusion criteria. These women will be asked to fulfill the International Physical Activity Questionnaire and additional questionnaire regarding relevant demographic and medical information (see below). Blood samples to anti-mullerian hormone , leptin, and hormonal profile will be obtained in day 3 of menstruation. Ultrasound will be performed to measure Antral Follicular count and ovarian blood flow. Data collection: Demographic information on age, weight, height, BMI, marital status Medical information regarding chronic diseases and medications Obstetrical history Information regarding physical activities in the version of International Physical Activity Questionnaire . Information about menstrual behavior: irregularity (yes/no) frequency (less than 21 days between 21-35 days, over 35 days), menstrual duration (less than 3 days 3-7 days, or over 7 days) bleeding amount according to the number of pads per day (up to 1, 2, 4 or 5 pads). Hormonal profile - Follicle-stimulating hormone , Luteinizing hormone , progesterone, Estradiol, Thyroid-stimulating hormone . Antral Follicle Count, Anti-mullerian hormone Leptin levels -reflecting metabolic changes.

Official Title
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Open Study to Examine How Different Levels of Physical Activity Impact the Ovarian Reserve During the Pre-menopausal Period

Conditions
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Physical Exercise

Intervention / Treatment
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* Other: Physical exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Study group: Women between 20-35 years of age who practice high level of physical activity, as defined by International Physical Activity Questionnaire, for the past 3 years BMI 18-25 Regular menstruation Control group: Women between 20-35 years of age who practice low level of physical activity, as defined by International Physical Activity Questionnaire, for the past 3 years BMI 18-25 Regular menstruation Exclusion Criteria: 1. Polycystic ovary syndrome 2. Endometriosis 3. Diabetes 4. Hyper/hypothyroidism 5. BMI>25, BMI<18 6. Active or past eating disorder -

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental<br>Women who practice high level of physical activity, as defined by International Physical Activity Questionnaire, for the past 3 years | Other: Physical exercise<br>* Women who practice high level of physical activity, as defined by International Physical Activity Questionnaire, for the past 3 years will be recruited. These women will will be asked to fulfill the International Physical Activity Questionnaire and additional questionnaire regarding relevant demographic and medical information. Blood samples to anti-mullerian hormone , leptin, and hormonal profile will be obtained in day 3 of menstruation. Ultrasound will be performed to measure Antral Follicular count and ovarian blood flow<br>|
| Control group<br>Women who practice low level of physical activity, as defined by International Physical Activity Questionnaire, for the past 3 years | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Levels of anti-mullerian hormone |  | 3 days after period | 
| Number of Antral Follicle Count |  | 3 days after period | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Levels of Follicle-stimulating hormone |  | 3 days after period | 
| levels fo Luteinizing hormone |  | 3 days after period | 
| Levels of progesterone |  | 3 days after period | 
| Levels of estradiol |  | 3 days after period | 
| Levels of Thyroid-stimulating hormone |  | 3 days after period | 
| Levels of leptin |  | 3 days after period | 
| Menstrual duration |  | 3 days after period | 
| frequency of bleeding in every menstruation |  | 3 days after period | 
| amount of bleeding in every menstruation |  | 3 days after period |