Use of Compressed Sensing in Breast MRI

Study Overview
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Brief Summary
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Breast MRI is increasingly important in breast screening imaging. It is currently based on dynamic sequences after contrast injection whose temporal resolution must be less than 90 seconds with dynamic acquisitions at different times. These curves profiles are designed to differentiate benign from malignant lesions. Recently, Mann et al, (2014) showed that increasing the temporal resolution of dynamic acquisitions; lesion enhancement curves over time were more accurate than the curves usually performed. It seems necessary to work on sequences having better temporal resolution without compromising however spatial resolution.

Official Title
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Use of Compressed Sensing in Breast MRI

Conditions
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Breast Cancer

Intervention / Treatment
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* Other: 3.0 Tesla in Magnetic Resonance Imaging


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient to benefit a MRI in the assessment for a breast carcinoma Age >18 years old Assessment on 3.0 Tesla in Magnetic Resonance Imaging ECOG performance status ≤ 3 Ability to provide an informed written consent form Exclusion Criteria: Age < 18 years old Claustrophobia Contraindication to the injection of gadolinium contrast medium Contraindication to MRI Persons deprived of liberty or under supervision

Ages Eligible for Study
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Maximum Age: 18 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 3.0 Tesla in Magnetic Resonance Imaging<br> | Other: 3.0 Tesla in Magnetic Resonance Imaging<br>* Eligible patient will have a standard MRI. The images taken before 4min30 and after 6min after to the injection of gadolimium contrast medium will be carried out with the standard image acquisition. The images taken between 4min30 and 6min after the injection of gadolimium contrast medium will be carried out with the compressed sensing image acquisition.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Agreement between compressed sensing and standard image acquisition | Agreement between compressed sensing and standard image acquisition is defined by percentage of lesions detected by both modes of acquisitions | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Analysis of dammage contours | Analysis of lesions contours will be performed according to Bi-RADS classification | 1 day | 
| Image quality in compressed sensing acquisition | The image quality will be evaluated using a quality scale | 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Algorithms, Image Processing, Computer-Assisted/methods*, Magnetic Resonance Imaging/methods*, Data Compression, Breast Neoplasms