Impact of Tooth Loss and Denture on Oral Senses and Food Preferences

Study Overview
=================
Brief Summary
-----------------
Tooth loss impacts taste abilities and food intake. Present study aims at pertaining the impact of teeth loss and the replacement by means of complete denture on taste and trigeminal abilities, and on food preferences, and taste appetence.

Detailed Description
-----------------
Two groups of participants will be included. Participants wearing complete denture for at least one year (n=20) and their matched controls for age, sex, tobacco, and saliva secretion (n=20). Their oral sensory abilities of participants will be assessed including taste (electrogustometric thresholds, chemical taste identification ability) and trigeminal quantitative sensory testing. Food preferences and selectivity (Maitre et al., 2014) and taste appetence (Deglaire et al., 2012) will also be assessed.

Official Title
-----------------
Impact of Complete Tooth Loss and Denture on Oral Sensory Abilities and Food Preference

Conditions
-----------------
Tooth-loss

Intervention / Treatment
-----------------
* Procedure: Tooth removal and their replacement by means of a denture


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Study Group : being completely edentulous and wearing denture for at least one year, wearing denture during meals, with clean and stable dentures. Controls: controls Group : dentate subjects (25 teeth at leas, non endodontically treated) with molars in Angle's Class I occlusion, having no functional disturbance of mastication and not undergoing dental treatment at the time of the recording. Matched with subjects of the study group for age, sex, tabacco consumption, and saliva flow rate. Exclusion Criteria: Aged under 18 or over 80 Y, not consenting to participate suffering from dental periodontal or gum pain for the last month.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 79 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Control<br> | |
| Experimental: Tooth removal<br>Tooth removal and their replacement by means of a denture Teeth have been removed and replaced by means of dentures for at least one year | Procedure: Tooth removal and their replacement by means of a denture<br>* Teeth have been removed and replaced by means of dentures for at least one year<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| taste detection thresholds | Using an Electrogustometer | up to 30 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Chemical taste identification ability | Using taste strips (Burghard) | up to 30 days | 
| Quantitative sensory testing | Using an algometer, von frey filament, a thermode. | up to 30 days | 
| Food preferences and selectivity | Questionnaire food selectyivity and preference (Maitre et al., 2014) | up to 30 days | 
| Taste appetence | Questionnaire PrefQuest (Deglaire et al., 2012) | up to 30 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Teeth loss, edentulousness, denture, tast, trigeminal senses, oral sensory ability