linjc16/ctgov huggingface dataset:
The Healthcare Professionals and the Leishmaniasis

Study Overview
=================
Brief Summary
-----------------
The aim of this work was to investigate the healthcare professionals' knowledge about leishmaniasis in Divinópolis, an endemic county of Minas Gerais state, Brazil.

Official Title
-----------------
Leishmaniasis: the Healthcare Professionals' Knowledge in Endemic Area

Conditions
-----------------
Knowledge on Leishmaniasis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: work in the healthcare centers, in the case of primary care professionals; have a university degree for nurses, physicians, dentists and veterinarians; be working effectively at the time of the interview; accept the terms of the research through written informed consent. Exclusion Criteria: -

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of questions correctly answered |  | up to 1 year |
Application of Deep Learning to Jointly Assess Embryo Development to Improve Pregnancy Outcome of Embryo Transfer

Study Overview
=================
Brief Summary
-----------------
Aim of this research is to apply the deep learning automation based on Time-lapse imaging to jointly assess embryo development，so that it can ensure the consistency of embryo evaluation and improve the accuracy of evaluation.

Detailed Description
-----------------
This study is an observational prospective study after a retrospective analysis. It is a single-center study without randomization or blindness. In the early stage, 1000 patients are collected from three periods of embryo culture through Time-lapse to establish an automated joint evaluation system for the whole process of embryo development. At the later stage, the patients are divided into two groups: Time-Lapse imaging (TLI) +Artificial Intelligence(AI) assessment group and morphological assessment group. 100 patients with Day 5 single blastocyst transplantation are carried out to follow up the pregnancy outcome.

Official Title
-----------------
Application of Deep Learning Automation Based on Time-lapse Imaging to Jointly Assess Embryo Development to Improve Pregnancy Outcome of Single Blastocyst Transfer

Conditions
-----------------
Reproductive Medicine

Intervention / Treatment
-----------------
* Diagnostic Test: Automatic picture recognition
* Diagnostic Test: Manual Assessment Group


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: (1) Age < 40 years old; (2) Routine IVF cycles; (3) Period number ≤ 2; (4) The number of ova collected is 5-15; (5) BMI: 18-25 kg/m 2, follicle stimulating hormone(FSH) ≤ 12 IU/L on the third day; (6) Patients with more than 3 high-quality embryos on Day3 and performed single blastocyst transplantation on day 5. (7) Patient without endometrial factors. Exclusion Criteria: (1) Preimplantation Genetic Testing(PGT) is needed due to male infertility, ovulation cycle and chromosome abnormalities; (2) there are systemic diseases of clinical significance; (3) Pictures of blastocysts are not formed or available; (4) Incomplete or unclear image collection in prokaryotic, mitotic and blastocyst phases affected AI evaluation.

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| TLI+AI Assessment Group<br> | Diagnostic Test: Automatic picture recognition<br>* A machine that processes photographs automatically taken<br>|
| Morphological Assessment Group<br> | Diagnostic Test: Manual Assessment Group<br>* Manual recognition of pictures<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| implantation rate | the probability of successful implantation of the embryo into the uterus | 2022-2023 |
Registry (Prospective Cohort) for Heart Failure in Korea (KorAHF)

Study Overview
=================
Brief Summary
-----------------
KorAHF is a multi-center registry (prospective cohort) for acute decompensated heart failure patients in Korea. The aim of this registry is to analyze several causes affecting prognosis and survival and to develop new strategies for managing acute decompensated heart failure.

Official Title
-----------------
Registry (Prospective Cohort) for Heart Failure in Korea (KorAHF)

Conditions
-----------------
Acute Decompensated Heart Failure

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All consecutive hospitalized adult patients who have 1 and (2 and/or 3) Symptom and/or sign of heart failure Lung congestion Objective finding of LV systolic dysfunction (LVEF), or structural heart disease Exclusion Criteria: N.C.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| All consecutive hospitalized adult patients<br>All consecutive hospitalized adult patients who have 1 and (2 and/or 3) Symptom and/or sign of heart failure Lung congestion Objective finding of LV systolic dysfunction (LVEF), or structural heart disease. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality and Re-hospitalization of acute decompensated heart failure | In-hospital mortality Annual mortality Re-hospitalization | 5 years (tentative) | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Heart failure, Registry, Cohort, Heart Disease, Cardiovascular Diseases
Varicocelectomy To Treat Pain, Predictors Of Success

Study Overview
=================
Brief Summary
-----------------
there are many studies studying the effectiveness of surgical treatment in patients treated for infertility, but only a few reporting the results of varicocelectomy done for pain. This study attempted to examine the success rate of varicocele ligation when performed for the treatment of pain and to evaluate all the predictor factors that may affect the pain resolve

Detailed Description
-----------------
varicocelectomy for patients complaining of pain and studying the effectiveness and all predictors that can affect the degree of response

Official Title
-----------------
Varicocelectomy To Treat Pain, Predictors Of Success : A Prospective Study

Conditions
-----------------
Pain

Intervention / Treatment
-----------------
* Procedure: varicocelectomy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: painful varicocele after failure of medical therapy Exclusion Criteria: responders to medical therapy
Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: varicocelectomy<br>varicocelectomy for patients complaining of pain | Procedure: varicocelectomy<br>* varicocelectomy for painful varicocele<br>* Other names: varicocelctomy;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| pain resolve after varicocelectomy | degree of pain resolve after varicocelectomy | 3 months foloow up | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| semen parameters | count,motility, morphology based on WHO 1995 | 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
varicocele, pain
The Effect of Aspirin on Angiogenesis Proteins in Women on Tamoxifen Therapy

Study Overview
=================
Brief Summary
-----------------
Changes in major angiogenic proteins have been seen following initiation of tamoxifen and aromatase inhibitor therapy in women with breast cancer. One source of these proteins is the circulating platelet pool. The investigators hypothesize that in addition to their anti-platelet properties, agents such as aspirin can be used as targeted anti-angiogenesis therapy. The investigators will determine the influence of aspirin on the release of angiogenic proteins from platelets in 35 patients with breast cancer.

Official Title
-----------------
The Impact of the Anti-Platelet Agent Aspirin on Angiogenesis Proteins in Women With Breast Cancer

Conditions
-----------------
Breast Cancer, Angiogenesis

Intervention / Treatment
-----------------
* Drug: Aspirin


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Histologically or cytologically proven breast cancer Pre or post-menopausal Age >18 Completed adjuvant non-hormonal therapy >30 days prior to initiation of study (surgery and/or chemotherapy and/or radiation therapy) Platelet count and hemoglobin within normal ranges for local lab within 30 days of initiation of study therapy Receiving tamoxifen therapy for at least 90 days prior to initiation of study therapy, and is expected to continue that therapy for the duration of the study (75 days) Exclusion Criteria: Chemotherapy, radiation therapy or surgery within 30 days of study therapy Current use of aspirin, anti-platelet or anti-coagulation agents on a continuous basis Prior history of gastrointestinal or central nervous system bleeding, or documented or self-reported blood in stools or bright red blood per rectum

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 95 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: receive aspirin<br> | Drug: Aspirin<br>* 325 mg tablets, once daily for 45 days<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in pro-angiogenic and anti-angiogenic protein levels. |  | 75 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Breast cancer, Angiogenesis, Aspirin, Tamoxifen
The Effect of Adding Pain Relievers to Local Anesthesia Before Preforming Drainage in Peritonsillar Abscess

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to find if adding oral pain relievers as DYPIRON and TRAMADOL in addition to the local anesthesia injection, can help reducing the pain intensity in patients who diagnosed as Suffering from peritonsillar abscess (PTA)and treated by incision and drainage .

Detailed Description
-----------------
Control group: the patient will get local anesthesia injection with Lidocain. After 5 minutes- the DR will preform the incision and drainage of the abscess. Then the patient will be asked by the vas score, the the pain intensity that he feels. Intervention group:the patient will get dypiron 4 ml and tramadol 50 mg. after 40 minutes,the patient will get local anesthesia injection with Lidocain. After 5 minutes- the DR will preform the incision and drainage of the abscess.then the patient will be asked by the vas score, the the pain intensity that he feels.

Official Title
-----------------
The Efficiency of DYPIRON and TRAMADOL in Addition to Local Anesthesia Prior to Incision and Drainage Procedure in Peritonsillar Abscess

Conditions
-----------------
Peritonsillar Abscess

Intervention / Treatment
-----------------
* Drug: dypiron, tramadol


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria:patients with PTA in ages 18-65, who agreed to join the research - Exclusion Criteria:cave to dypiron and/or tramadol, pregnant women, mental illness,soldiers. -

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: dypiron, tramadol|dypiron 4 ML, tramadol 50 mg flashtab|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the vas scale |  | 40 min after giving the oral drugs |
Feasibility of Isolating P16 Expression

Study Overview
=================
Brief Summary
-----------------
Expression of the cell cycle regulator p16INK4a increases with age and toxic stressors. In mice, both radiation and chemotherapy are known to increase p16. Due to its influence on age-related regenerative capacity, p16 is an excellent candidate biomarker of physiologic reserve that may identify patients able to withstand the stressor of chemotherapy (low p16) from those unlikely to tolerate chemotherapy (high p16). That is, expression of p16 may predict physiologic, rather than chronologic, age. Such findings could have implications for care of cancer survivors and treatment decision-making in cancer patients. STUDY OBJECTIVE: This is an observational pilot study to determine the feasibility of isolating p16INK4a in CD3+ T lymphocytes in adults treated with chemotherapy for cancer during childhood.

Detailed Description
-----------------
At St. Jude Children's Research Hospital, survivors who meet the eligibility criteria will be identified from SJLIFE protocol participants. After signing consent, the subject will have a blood specimen collected at the same time as the blood draw for the SJLIFE protocol. These samples will have T cell isolation performed then placed on ice and stored until batch shipment for investigation of p16 expression.

Official Title
-----------------
Feasibility of Isolating P16 Expression

Conditions
-----------------
Childhood Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Enrolled in the SJLIFE study at St. Jude children's Research Hospital. Survivor of childhood cancer. Is 18 years of age and older. No evidence of cancer recurrence. Received prior chemotherapy (prior radiotherapy is allowed). Exclusion Criteria: Inability or refusal to give consent.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of samples with successful isolation of expression of p16INK4a in CD3+ T lymphocytes | Blood samples will be drawn once at a regularly scheduled follow-up visit. After T cells are isolated, the samples will be sent in one batch for further processing and investigation of p16 expression. | Within 3 months of enrollment of the last participant | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
p16, T cell isolation, physiologic age
Involvement of Lymphocyte Type B in Amyotrophic Lateral Sclerosis (ALS)

Study Overview
=================
Brief Summary
-----------------
The involvement of Lymphocyte type B in Amyotrophic lateral sclerosis (ALS) patients will be compared to lymphocyte in healthy subjects.

Official Title
-----------------
Involvement of Lymphocyte Type B in Amyotrophic Lateral Sclerosis (ALS)

Conditions
-----------------
Amyotrophic Lateral Sclerosis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: ALS patients who could sign ICF. Exclusion Criteria: No ALS patients age less than 18 years.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 100 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1 ALS patients<br> | |
| 2 Healthy subjects<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Culturally Sensitive Depression Care Management for Latino Primary Care Patients

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine whether telephonic depression care management can improve depression outcomes for Latino primary care patients who are enrolled in Medicaid and are receiving an antidepressant from their primary care doctor.

Official Title
-----------------
Culturally Sensitive Depression Care Management for Latino Primary Care Patients

Conditions
-----------------
Depression

Intervention / Treatment
-----------------
* Behavioral: telephone depression care management


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Latino Adult Received an antidepressant prescription from primary care provider Not current receiving care from behavioral health provider Diagnosis of major depression, minor depression, dysthymia, or significant depression symptoms English or Spanish speaking Member, Neighborhood Health Plan of RI

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>Telephone depression care management + treatment as usual | Behavioral: telephone depression care management<br>* 1 call per week for first 4 weeks 1 call every other week for next 8 weeks<br>|
| No Intervention: 2<br>Treatment as usual | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quick Inventory of Depressive Symptomatology - Clinician Administered (QIDS-C) |  | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Center for Epidemiological Studies-- Depression |  | 3 months | 
| WHO Disability Assessment Schedule (WHO-DAS) |  | 3 months | 
| Treatment Utilization |  | 3 months | 
| Treatment Satisfaction |  | 3 months | 
| costs: health care utilization |  | 3 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
depression, primary care, Latino, telephone, care management
Follow-up of Eating Disorder Patients From a 15-year Period.

Study Overview
=================
Brief Summary
-----------------
Retrospective follow-up study of former eating disorder patients in child- and adolescent psychiatry on psychiatric symptoms and social intelligence.

Detailed Description
-----------------
Former patients and their parents were contacted 3 to 15 years after their completed treatment for eating disorders at Levanger Hospital, Child and Adolescent Psychiatry Department, in the period from 1988 to 2002. Interviews focusing on general psychiatric symptom, specific eating disorder symptoms, social intelligence and consumer satisfaction. Parents were also contacted and interviewed on consumer satisfaction.

Official Title
-----------------
Follow-up Eating Disorder Patients and Their Parents Leaving Treatment From 1988 to 2002 at Child and Adolescent Department at Levanger Hospital.

Conditions
-----------------
Eating Disorder Symptoms

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Eating disorder symptoms or disorder Exclusion Criteria: -

Ages Eligible for Study
-----------------
Minimum Age: 8 Years
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |