Mother Daughter Bone Microarchitecture

Study Overview
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Brief Summary
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The aim of this study is to analyze the hereditary determinism of bone microarchitecture measured at the distal radius and distal tibia from a case control-study of mother-daughter pairs.

Detailed Description
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Many factors influence the risk of osteoporosis but one of the most important is a positive family history, emphasizing the importance of genetics in the pathogenesis of osteoporosis. Till now, most genetic studies in osteoporosis have focused on the phenotype of BMD. However, areal BMD (bone quantity per unit bone area measured) does not provide information regarding bone distribution (between cortical and cancellous compartments) or bone microarchitecture (trabecular number, thickness, spacing and distribution) and cortical (thickness, porosity). We are planning to analyze the hereditary determinism of bone microarchitecture assessed non invasively with HR pQCT at the distal radius and the distal tibia in a case-control study with fractured and not fractured mothers and their daughters. Additionally, the role of the bone turnover, hormones involved in regulating bone metabolism , bone geometry measured at the proximal femur and bone strength estimated by finite element analysis (μFE)in the hereditary determinism of bone fragility will be analyzed.

Official Title
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Rôle de la Microarchitecture Osseuse Dans le déterminisme héréditaire de la fragilité Osseuse

Conditions
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Bone Fragility

Intervention / Treatment
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* Radiation: HRpQCT
* Biological: Sampling
* Radiation: Bone absorptiometry


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Case mothers: postmenopausal women who have at least one bone fragility fracture confirmed by radiological examination or by a surgical report. Fragility fracture is a fracture that occurs as a result of a fall from standing height or less. Fractures of the skull, fingers and toes will be excluded. Control mothers: menopausal women not having suffered from bone fragility fracture. Daughters: Women aged 20 and older (postmenopausal or not), biological daughters of participating mothers. Several daughters from the same mother may be included. Mothers and some daughters are recruited from the OFELY (Os des FEmmes de LYon) cohort or the FMC (Filière MédicoChirurgicale). Exclusion Criteria: Adoptive daughters Nonmenopausal mothers

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Fractured Mothers<br>Fractured Mothers and their daughters | Radiation: HRpQCT<br>* High Resolution peripheral Quantitative Computerized tomography<br>* Other names: XTreme CT,Scanco Medical, Bassersdorf, Switzerland;Biological: Sampling<br>* Urine and blood samples<br>* Other names: Bone markers, hormones;Radiation: Bone absorptiometry<br>* DXA at the lumbar spine, hip, radius and whole body<br>* Other names: Hologic, Waltham,MA, USA;|
| Non fractured mothers<br>Mothers non fractured and their daughters | Radiation: HRpQCT<br>* High Resolution peripheral Quantitative Computerized tomography<br>* Other names: XTreme CT,Scanco Medical, Bassersdorf, Switzerland;Biological: Sampling<br>* Urine and blood samples<br>* Other names: Bone markers, hormones;Radiation: Bone absorptiometry<br>* DXA at the lumbar spine, hip, radius and whole body<br>* Other names: Hologic, Waltham,MA, USA;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Role of bone microarchitecture in the hereditary determinism of bone fragility | Comparison of bone microarchitecture parameters from high resolution peripheral quantitative computer tomography (HRpQCT)between daughters according to the fracture status of their mother. | 18 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Role of Bone mineral density in the hereditary determinism of bone fragility | Comparison of BMD from DXA at the hip, the lumbar spine, the forearm and whole body, between daughters according to the fracture status of their mother. | 18 months | 
| Role of bone turnover and hormones in the hereditary determinism of bone fragility | Comparison of Bone markers and hormone levels between daughters according to the fracture status of their mother. | 24 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Bone microarchitecture, Bone mineral density, Bone markers, hereditary determinism