Monofocal Extended Range of Vision (MERoV) Study

Study Overview
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Brief Summary
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The investigators are proposing this research project to: Screen a set of patients after normal cataract surgery with a single focus lens aimed at good distance vision at 3 months after surgery to identify patients who are able to see and read well without glasses. Identify the combination of factors responsible for this phenomenon in the patients who are achieving this. Potentially eligible patients will be given an invitation letter and patient information sheet on the day they arrive for surgery. They will then be asked if they are happy to be contacted by phone 2-4 weeks post-surgery with a view to booking them into an additional research visit at 3 months after their surgery. At 3 months after surgery they will have their un-corrected vision checked. They will also have their reading speed assessed without any glasses. They will undergo a through refractive check by an optometrist to assess the power of the spectacles (if needed) and following this they will have a scan of the eye (a technique known as wave front analysis which uses very sophisticated optics) to capture the optical distortions in the structures of the eye. If this study is able identify factor/s responsible for giving good unaided reading and distance vision then this factor can be reproduced in eyes undergoing cataract surgery. This will mean that the patients can have an increased option of spectacle independence without the need for expensive multifocal IOLs and their associated side effects such as glare and halos, particularly at night.

Detailed Description
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TYPE OF THE STUDY: A prospective, non-blinded, non-randomized, single eye cohort study in patients who had uneventful cataract surgery with a monofocal IOL. Potentially eligible patients will be given an invitation letter and patient information sheet on the day they arrive for surgery. They will then be asked if they are happy to be contacted by phone 2-4 weeks post-surgery with a view to booking them into an additional research visit at 3 months after their surgery. Inclusion criteria Uneventful cataract surgery Sequential recruitment Potential to see 20/40 (6/12) unaided or better postoperatively No significant macular pathology Willing to follow up at 3 months Exclusion criteria Patients under 20 years of age Any ocular co-morbidity, which will preclude an expected postoperative 20/40 (6/12) unaided, distance vision. (e.g. amblyopia, corneal pathology, age related macular degeneration, glaucoma, diabetic retinopathy, other previous ocular surgeries) Posterior capsule opacification Inability to read English text or physically or mentally unable to cooperate with the postoperative assessment At 3 months, uniocular unaided distance LogMAR acuity will be recorded. An OCT scan will be performed to establish macular integrity. Pupil size, manifest refraction, measurement of any deviations of the optical rays (called as wavefront aberrometry) will be performed using a iTrace (Tracy Technology) wavefront aberrometer. Unaided reading speed and critical print size will be measured using a Salzberg Reading Desk. Examination time per patient: 40 mins in total. Multivariate statistical analysis will be performed. Power calculation showed a need to examine 412 patients.

Official Title
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Monofocal Extended Range of Vision (MERoV) Study

Conditions
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Pseudophakia, Accomodation, Aberration, Corneal Wavefront

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Uneventful cataract surgery, sequential recruitment, potential to see 20/40 (6/12) unaided or better postoperatively, no significant macular pathology and willing to follow up at 3 months. Exclusion Criteria: Any ocular co-morbidity, which will preclude an expected postoperative 20/40 (6/12) unaided, distance vision. (e.g. amblyopia, corneal pathology, age related macular degeneration, glaucoma, diabetic retinopathy, other previous ocular surgeries), posterior capsule opacification,inability to read English text or physically or mentally unable to and cooperate with the postoperative assessment

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Uncorrected distance and near vision | Uncorrected distance of 20/40 and near of J4 | 3 months postoperatively | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Spherical error | Spherical error on manifest refraction | 3 months postoperatively | 
| astigmatic error | astigmatic error on manifest refraction | 3 months postoperatively | 
| Pupil size | Pupil size in mesopic condition | 3 months postoperatively | 
| Total spherical and vertical coma aberrations | Total spherical and vertical coma aberrations on aberrometry | 3 months postoperatively | 
| Reading speed and critical font size | Measured on Salzburg's reading desk | 3 months postoperatively | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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pseudoaccommodation, monofocal IOL, cataract surgery