Postoperative Pain After the Use of Different Root Canal Sealers

Study Overview
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Brief Summary
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This study evaluated the postoperative pain after the endodontic treatment using AH Plus, Endoseal MTA and EndoSequence BC sealers in root canal obturation.

Official Title
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Effect of Two Different Calcium Silicate Based and One Epoxy Resin-based Root Canal Sealers on Postoperative Pain After Root Canal Treatments

Conditions
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Postoperative Pain

Intervention / Treatment
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* Other: Root Canal Filling Sealers


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Participants between 18 - 60 years of age, Good oral hygiene, Have not taken any analgesics in the last day, Have not taken antibiotics in the last week, Patients diagnosed with asymptomatic irreversible pulpitis caused by deep carious lesion on the mandibular first or second molar teeth. A prolonged positive response to cold vitality tests, The presence of pulp, which is exposed during caries removing and bleeding with a dense and thick consistency. The periapical region was healthy in radiographic diagnosis. Exclusion Criteria: Devital teeth that have no response to pulp test, The presence of advanced periodontal disease, Having a systemic disease that requires antibiotic prophylaxis, Radiographically more than 30° root inclination, presence of clear apex, presence of calcification, presence of root resorption, The need for root canal treatment which is mesial and/or distal neighbour of the tooth to be treated, The presence of a sinus tract in the relevant tooth region, Having systemic diseases that reduce immune system resistance, Participants with allergic sensitivity to materials and agents that should be used during the root canal treatment, Allergic sensitivity to local anesthetics, Pregnant participants or participants in the lactation period, Over preparation or over filling during treatment, Teeth which cannot be applied a rubber-dam, Teeth which was damaged enough to require coronal fiber post application, Sensitive to Ibuprofen based analgesics.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: AH-Plus<br> | Other: Root Canal Filling Sealers<br>* Root Canal Obturation<br>|
| Experimental: EndoSeal MTA<br> | Other: Root Canal Filling Sealers<br>* Root Canal Obturation<br>|
| Experimental: Endosequence BC Sealer<br> | Other: Root Canal Filling Sealers<br>* Root Canal Obturation<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain level comparison after root canal obturation with three different endodontic sealers: VAS (Visual Analogue Scale) at 6th hours. | Based on the VAS (Visual Analogue Scale), the pain levels of the patients were assessed. The scale consisted of a 100-mm-long line divided into 10 equal intervals from 0 (no pain) to 100 (very severe pain). Every patient was asked to mark his or her perceived postoperative pain level on the line. | 6th hours | 
| Pain level comparison after root canal obturation with three different endodontic sealers: VAS (Visual Analogue Scale) at 12th hours. | Based on the VAS (Visual Analogue Scale), the pain levels of the patients were assessed. The scale consisted of a 100-mm-long line divided into 10 equal intervals from 0 (no pain) to 100 (very severe pain). Every patient was asked to mark his or her perceived postoperative pain level on the line. | 12th hours | 
| Pain level comparison after root canal obturation with three different endodontic sealers: VAS (Visual Analogue Scale) at 24th hours. | Based on the VAS (Visual Analogue Scale), the pain levels of the patients were assessed. The scale consisted of a 100-mm-long line divided into 10 equal intervals from 0 (no pain) to 100 (very severe pain). Every patient was asked to mark his or her perceived postoperative pain level on the line. | 24th hours | 
| Pain level comparison after root canal obturation with three different endodontic sealers: VAS (Visual Analogue Scale) at 48th hours. | Based on the VAS (Visual Analogue Scale), the pain levels of the patients were assessed. The scale consisted of a 100-mm-long line divided into 10 equal intervals from 0 (no pain) to 100 (very severe pain). Every patient was asked to mark his or her perceived postoperative pain level on the line. | 48th hours | 
| Pain level comparison after root canal obturation with three different endodontic sealers: VAS (Visual Analogue Scale) at 3rd days. | Based on the VAS (Visual Analogue Scale), the pain levels of the patients were assessed. The scale consisted of a 100-mm-long line divided into 10 equal intervals from 0 (no pain) to 100 (very severe pain). Every patient was asked to mark his or her perceived postoperative pain level on the line. | 3rd days | 
| Pain level comparison after root canal obturation with three different endodontic sealers: VAS (Visual Analogue Scale) at 4th days. | Based on the VAS (Visual Analogue Scale), the pain levels of the patients were assessed. The scale consisted of a 100-mm-long line divided into 10 equal intervals from 0 (no pain) to 100 (very severe pain). Every patient was asked to mark his or her perceived postoperative pain level on the line. | 4th days | 
| Pain level comparison after root canal obturation with three different endodontic sealers: VAS (Visual Analogue Scale) at 5th days. | Based on the VAS (Visual Analogue Scale), the pain levels of the patients were assessed. The scale consisted of a 100-mm-long line divided into 10 equal intervals from 0 (no pain) to 100 (very severe pain). Every patient was asked to mark his or her perceived postoperative pain level on the line. | 5th days | 
| Pain level comparison after root canal obturation with three different endodontic sealers: VAS (Visual Analogue Scale) at 6th days. | Based on the VAS (Visual Analogue Scale), the pain levels of the patients were assessed. The scale consisted of a 100-mm-long line divided into 10 equal intervals from 0 (no pain) to 100 (very severe pain). Every patient was asked to mark his or her perceived postoperative pain level on the line. | 6th days | 
| Pain level comparison after root canal obturation with three different endodontic sealers: VAS (Visual Analogue Scale) at 7th days. | Based on the VAS (Visual Analogue Scale), the pain levels of the patients were assessed. The scale consisted of a 100-mm-long line divided into 10 equal intervals from 0 (no pain) to 100 (very severe pain). Every patient was asked to mark his or her perceived postoperative pain level on the line. | 7th days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Analgesic intake comparison after root canal obturation with three different endodontic sealers at 6th hours. | The patients were asked to choose one of the three options: 0: No pain, or no pain which does not require the use of analgesics, 1: Moderate pain which can be controlled very well by the use of analgesics and does not affect daily activities or sleep, 2: Daily activities Unbearable pain that cannot be controlled by the use of analgesics | 6th hours | 
| Analgesic intake comparison after root canal obturation with three different endodontic sealers at 12th hours. | The patients were asked to choose one of the three options: 0: No pain, or no pain which does not require the use of analgesics, 1: Moderate pain which can be controlled very well by the use of analgesics and does not affect daily activities or sleep, 2: Daily activities Unbearable pain that cannot be controlled by the use of analgesics | 12th hours | 
| Analgesic intake comparison after root canal obturation with three different endodontic sealers at 24th hours. | The patients were asked to choose one of the three options: 0: No pain, or no pain which does not require the use of analgesics, 1: Moderate pain which can be controlled very well by the use of analgesics and does not affect daily activities or sleep, 2: Daily activities Unbearable pain that cannot be controlled by the use of analgesics | 24th hours | 
| Analgesic intake comparison after root canal obturation with three different endodontic sealers at 48th hours. | The patients were asked to choose one of the three options: 0: No pain, or no pain which does not require the use of analgesics, 1: Moderate pain which can be controlled very well by the use of analgesics and does not affect daily activities or sleep, 2: Daily activities Unbearable pain that cannot be controlled by the use of analgesics | 48th hours | 
| Analgesic intake comparison after root canal obturation with three different endodontic sealers at 3rd days. | The patients were asked to choose one of the three options: 0: No pain, or no pain which does not require the use of analgesics, 1: Moderate pain which can be controlled very well by the use of analgesics and does not affect daily activities or sleep, 2: Daily activities Unbearable pain that cannot be controlled by the use of analgesics | 3rd days | 
| Analgesic intake comparison after root canal obturation with three different endodontic sealers at 4th days. | The patients were asked to choose one of the three options: 0: No pain, or no pain which does not require the use of analgesics, 1: Moderate pain which can be controlled very well by the use of analgesics and does not affect daily activities or sleep, 2: Daily activities Unbearable pain that cannot be controlled by the use of analgesics | 4th days | 
| Analgesic intake comparison after root canal obturation with three different endodontic sealers at 5th days. | The patients were asked to choose one of the three options: 0: No pain, or no pain which does not require the use of analgesics, 1: Moderate pain which can be controlled very well by the use of analgesics and does not affect daily activities or sleep, 2: Daily activities Unbearable pain that cannot be controlled by the use of analgesics | 5th days | 
| Analgesic intake comparison after root canal obturation with three different endodontic sealers at 6th days. | The patients were asked to choose one of the three options: 0: No pain, or no pain which does not require the use of analgesics, 1: Moderate pain which can be controlled very well by the use of analgesics and does not affect daily activities or sleep, 2: Daily activities Unbearable pain that cannot be controlled by the use of analgesics | 6th days | 
| Analgesic intake comparison after root canal obturation with three different endodontic sealers at 7th days. | The patients were asked to choose one of the three options: 0: No pain, or no pain which does not require the use of analgesics, 1: Moderate pain which can be controlled very well by the use of analgesics and does not affect daily activities or sleep, 2: Daily activities Unbearable pain that cannot be controlled by the use of analgesics | 7th days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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postoperative pain, Endoseal MTA, Endosequence BC, AH Plus, Root canal filling, endodontic treatment