Excimer Laser, Serum Markers & Psoriasis

Study Overview
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Brief Summary
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The overall aims for this study are to determine whether UVB excimer laser treatment of psoriasis affects serum inflammatory markers, and to assess hyperpigmentation and erythema with excimer laser treatment. The investigators hypothesize that treatment of psoriasis with UVB delivered via 308 nm excimer laser will decrease the levels of serum inflammatory markers. The investigators hypothesize that treatment will decrease plaque erythema and will result in minimal hyperpigmentation.

Detailed Description
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Subjects will undergo Excimer treatment twice a week until they reach a PASI 75 improvement, or until they reach the maximum of 20 total treatments. A blood draw to assess serum inflammatory markers will be performed at the screening visit and final visit. Chromameter assessment, photographs, PASI and PGA (Physician Global Assessment) will be performed throughout the study to monitor psoriasis improvement, hyperpigmentation and erythema.

Official Title
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Effects of UVB Excimer Laser on Serum Inflammatory Markers in Patients With Psoriasis

Conditions
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Psoriasis

Intervention / Treatment
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* Device: Excimer laser treatment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 18 years and older Male or female with diagnosis of psoriasis Psoriasis involvement of 5-15% BSA Has been off systemic psoriasis therapies (e.g. retinoids, methotrexate, biologic agents, etc) for at least 4 weeks Has been off topical therapies (e.g. calcipotriene, topical steroids) for at least 2 weeks Fitzpatrick Skin Types I-VI Exclusion Criteria: Active history of photosensitivity (e.g. xeroderma pigmentosum, lupus erythematosus, porphyria, severe polymorphous light eruption, solar urticaria) Any suspicion that the psoriasis is of the photosensitive variant. Any medical condition that could be aggravated or may cause extreme discomfort during the study period.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Excimer laser<br>Excimer laser treatment | Device: Excimer laser treatment<br>* Excimer laser irradiation twice a week for up to 20 treatments.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in serum inflammatory markers | Change in CRP, MPO, S100 and Resistin levels from screening to final visit. | 23 visits ( 12 weeks) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Objective measure of hyperpigmentation | Chromameter Assessment to measure hyperpigmentation. L* values are measured with a chromameter. A lower L* means more hyperpigmentation. | 23 visits ( 12 weeks) | 
| Objective measure of erythema | Chromameter Assessment to measure erythema. a* values are measured with a chromameter. A higher a* means more erythema. | 23 visits ( 12 weeks) | 
| Improvement in Psoriasis based on PASI assessment | PASI will be performed throughout the study to assess response to treatment. | 23 visits ( 12 weeks) | 
| Improvement in psoriasis based on PGA | PGA (Physician Global Assessment) will be performed throughout the study to assess response to treatment. | 23 visits ( 12 weeks) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Excimer laser, UVB, Psoriasis