The Efficacy of Oral Antiseptics Against COVID-19

Study Overview
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Brief Summary
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In a study conducted on 75 COVID-19 patients, the effect of SARS-CoV-2 on viral load was investigated as a result of the use of hypochlorous acid and povidone-iodine as an oral antiseptic.

Detailed Description
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Before and 30 minutes after rinsing with mouth antiseptics, the participants were asked to rinse the mouth and throat for 30 seconds with 0.9% isotonic saline. The sample was sputtered into a sterile plastic container. The participants were grouped according to the type of oral antiseptics used. The effectiveness of SARS-CoV-2 viral load was investigated by rinsing the mouth and throat for 30 seconds with 20 ml of hypochlorous acid, povidone-iodine, and isotonic saline. Viral load was analyzed by RT-PCR analysis. The results were evaluated by statistical analysis.

Official Title
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The Effectiveness of Oral Antiseptics on the Intraoral Viral Load of SARS-CoV-2

Conditions
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COVID-19

Intervention / Treatment
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* Drug: Hypochlorous Acid 0.02% Soln,Top (Crystaline) (HClO)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Positive SARS-CoV-2 RT-PCR result, Adult hospitalized patient, The participants have the physical and psychological ability to follow the instructions in the study. Exclusion Criteria: Patients intubated and supported by a mechanical respirator, Severe acute or chronic medical or psychiatric condition, History of significant adverse effects following use of oral hygiene products such as toothpaste and mouth rinses, Active uncontrolled thyroid disease, Developmental/cognitive disability, Pregnancy, Undergoing radioactive iodine therapy.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Hypochlorous acid group<br>The effect of 0.02% Hypochlorous acid solution on viral load was investigated by using 25 COVID-19 patients as an oral antiseptic for 30 seconds. | Drug: Hypochlorous Acid 0.02% Soln,Top (Crystaline) (HClO)<br>* SARS-CoV-2 sample was obtained from COVID-19 patients by rinsing the mouth and throat with 5 ml of isotonic saline before and 30 minutes after rinsing. In the hypochlorous acid group, 20 ml of HClO was asked to be rinsed in the mouth and throat for 30 seconds in 25 participants. In the povidone-iodine group, 20 ml of PVP-I was asked to be rinsed in the mouth and throat for 30 seconds in 25 participants. In the saline group, 20 ml of saline was asked to be rinsed in the mouth and throat for 30 seconds in 25 participants.<br>* Other names: Isotonic saline 0.9% (Gifrer);|
| Active Comparator: Povidone-iodine group<br>The effect on viral load was investigated by using 0.5% Povidone-iodine solution as an oral antiseptic for 30 seconds in 25 COVID-19 patients. | Drug: Hypochlorous Acid 0.02% Soln,Top (Crystaline) (HClO)<br>* SARS-CoV-2 sample was obtained from COVID-19 patients by rinsing the mouth and throat with 5 ml of isotonic saline before and 30 minutes after rinsing. In the hypochlorous acid group, 20 ml of HClO was asked to be rinsed in the mouth and throat for 30 seconds in 25 participants. In the povidone-iodine group, 20 ml of PVP-I was asked to be rinsed in the mouth and throat for 30 seconds in 25 participants. In the saline group, 20 ml of saline was asked to be rinsed in the mouth and throat for 30 seconds in 25 participants.<br>* Other names: Isotonic saline 0.9% (Gifrer);|
| Placebo Comparator: Saline group<br>The effect on viral load was investigated by using 0.9% isotonic saline solution as a placebo for 30 seconds in 25 COVID-19 patients. | Drug: Hypochlorous Acid 0.02% Soln,Top (Crystaline) (HClO)<br>* SARS-CoV-2 sample was obtained from COVID-19 patients by rinsing the mouth and throat with 5 ml of isotonic saline before and 30 minutes after rinsing. In the hypochlorous acid group, 20 ml of HClO was asked to be rinsed in the mouth and throat for 30 seconds in 25 participants. In the povidone-iodine group, 20 ml of PVP-I was asked to be rinsed in the mouth and throat for 30 seconds in 25 participants. In the saline group, 20 ml of saline was asked to be rinsed in the mouth and throat for 30 seconds in 25 participants.<br>* Other names: Isotonic saline 0.9% (Gifrer);|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| RT-PCR analysis | For the quantitative analysis of the amount of SARS-CoV-2 RNA in the obtained samples, the Real-time Reverse Transcyptase Polymerase Chain Reaction method was used. | two weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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COVID-19, Viral load, Antiseptic, Povidone-iodine, Hypochlorous acid