Impact of Glistenings in AcrySof Intraocular Lenses on Visual Quality

Study Overview
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Brief Summary
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This study will assess the impact of IOL glistenings on visual quality and function in patients implanted with a single-piece AcrySof intraocular lens (IOL) that exhibits glistening formations. The primary objective is to determine if random light scattering (measured by C-Quant)correlates with severity of glistenings, other objective measures of visual function (visual acuity, low contrast visual acuity, low contrast visual acuity with glare), and subjective measures of patients' perceptions of their visual quality after cataract surgery (quality of life survey, reports of symptomology and satisfaction).

Official Title
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Impact of IOL Glistenings on Visual Quality and Function in Patients Implanted With a Single-Piece AcrySof IOL That Exhibits Glistening Formation

Conditions
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Lenses, Intraocular, Glistenings, Visual Quality

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Presence of obvious glistenings by slit lamp exam Best spectacle corrected visual acuity of 20/20 or better on the Snellen chart at most recent exam Exclusion Criteria: Any central corneal pathology that could have impact on vision other than mild guttata felt unlikely to have any impact on corneal clarity. Any documented glaucoma of any kind. Any macular pathology except minimal drusen without retinal pigment epithelial pathology felt to be consistent with normal vision. Any diabetic retinopathy other than minimal background diabetic retinopathy felt unlikely to affect vision. Any other cause of central visual acuity loss including optic nerve, occipital cortex dysfunction or amblyopia. Diagnosis of dry eye syndrome, defined as any corneal staining with fluorescein Presence of any central posterior capsular opacification. Previous YAG laser capsulotomy is allowed. Any surgical complication having to do with the capsule such as a broken capsule or zonular dialysis or iris trauma or any other complication felt to in any way impact upon the quality of the visual result. Any contraindication to pupil dilation
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group 1<br>Patients who had cataract surgery by the Investigators between July 1, 2007 and June 30, 2008. | |
| Group 2<br>Patients who had cataract surgery by the Investigators between July 1, 2008 and July 1, 2009. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Light scattering | Correlation of random light scattering (measured with the C-Quant device) with severity of glistenings in the lenses | Post-opertative | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Visual function | Correlation of visual function (visual acuity, contrast acuity and constrast acuity with glare)with glistening severity | Post-operative | 
| Visual quality | Correlation of visual quality (measured with quality of life questionnaire, and subjective reports of symptoms) with glistening severity | Post-operative | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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glistenings, contrast sensitivity, visual quality, straylight, AcrySof IOL