Look at Food and Lose Your Fear - Evaluation of a Computerized Attention Training (CAT) for Anorexia Nervosa Patients

Study Overview
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Brief Summary
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The purpose of this study is to test the therapeutic effects of a computerized attention training for patients with Anorexia Nervosa (AN). The primary aim is to determine if a computerized attention training can modify attention towards food and ameliorate eating disorder symptoms and related difficulties, such as anxiety. The secondary aim is to explore underlying mechanisms that contribute to these improvements. The stability of potentially observed effects over a one-month period will also be determined.

Detailed Description
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Recently, attention bias modification (ABM) has successfully been applied in the field of anxiety disorders and emerging evidence suggests that attention bias modification can ameliorate attention bias for threatening stimuli. ABM is based on the premise that if biased attention maintains disorder symptoms, a modification of the bias should reduce symptoms. The advantage of ABM is that it operates implicitly, thereby offering a more indirect, less deliberate procedure. This requires less cognitive control compared to the effortful and explicit psychotherapeutic treatment of cognitive biases. As food-related fears and avoidance in AN patients have been recognized as important anxiety-related symptoms, ABM seems particularly suitable to treat food-related fears and avoidance, especially because AN patients might be unaware of their avoidance strategy. The aim of this study is to test if food-related fears and food avoidance can be changed by experimentally modifying attention towards food in Anorexia Nervosa patients using an innovative computerized training paradigm (computerized attention training - CAT) and to evaluate related change in symptoms. The investigators hypothesize that the active CAT will change attentional processing of food cues (research aim 1), transfer to changes in food-related fears and food avoidance, and to improvements in AN symptoms and weight in the short term (research aim 2) and longer term (research aim 3).

Official Title
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Evaluation of a Computerized Attention Training (CAT) to Modify Attention Bias for Food Cues in Anorexia Nervosa Patients

Conditions
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Anorexia Nervosa

Intervention / Treatment
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* Behavioral: Computerized attention training (CAT)
* Behavioral: Sham computerized attention training (control condition)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: BMI < 18.5 5 kg/m2 Current diagnosis of AN-restricting type, AN-Binge/purging type or Eating Disorder Not Otherwise Specified (EDNOS) - Anorexia type Fluent in English Exclusion Criteria: Currently taking a dose of any psychoactive medication that has not been stable for at least 14 days prior to participation in the study Currently meeting the diagnostic criteria of another major psychiatric disorder (e.g., major depressive disorder, substance dependence, schizophrenia or bipolar disorder) needing treatment in its own right Learning and developmental impairments If the disorder is currently life threatening If patients are currently suicidal If patients are currently having extreme physiological complications or co-morbid alcohol and drug-abuse disorders

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: CAT active attention bias modification<br>Active computerized attention training (CAT). Attention training via repeated trials of a modified anti-saccade task with concurrent assessment of eye-movements intended to direct attention towards food stimuli using pictorial food and non-food stimuli (see Werthmann, Field, Roefs, Nederkoorn, & Jansen, 2014). | Behavioral: Computerized attention training (CAT)<br>* Three sessions of active computerized attention training.<br>* Other names: Attention bias modification training;|
| Placebo Comparator: CAT sham bias modification<br>Sham computerized attention training. Attention training via repeated trials of a modified anti-saccade task with concurrent assessment of eye-movements not intended to change attention processing of food stimuli using pictures of two different non-food stimuli categories (e.g. household and musical instruments). | Behavioral: Sham computerized attention training (control condition)<br>* Three sessions of sham computerized attention training.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Attention bias | The dot-probe task with concurrent assessment of eye-movements will be used for the assessment of attention bias at baseline and post-treatment. | max. 2 weeks (pre and post attention bias modification training) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Eating Disorder symptoms | The Eating Disorder Examination Questionnaire (EDE-Q, Fairburn & Belgin, 1994) is a commonly used index for AN symptoms and will be assessed at baseline and post-treatment and at 4 weeks follow-up. | max. 2 week (pre and post attention bias modification training) and at 4 weeks follow-up | 
| Body Mass Index | Weight and height will be assessed to calculate BMI and assess whether BMI changes occurred during the study period due to CAT | max. 2 (pre and post attention bias modification training) and after 4 weeks (follow-up). | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Eating Disorders, Anorexia Nervosa, Attention bias, Attention bias modification