Single Application of Desensitizing Pastes as Dentin Sensitivity Treatment

Study Overview
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Brief Summary
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The aim of this study was to evaluate the efficacy of three desensitizing toothpastes for immediate and intermediate-term relief of CDH, when compared with a control toothpaste. One hundred and thirty-eight hypersensitive teeth were diagnosed and randomized into four groups according to the therapeutic agent of each desensitizing cream tested: 1) strontium acetate and calcium carbonate, 2) calcium carbonate and arginine 8%, 3) calcium phosphate nanoparticles and 4) a control toothpaste. The desensitizing creams were applied according to the manufacturer's instructions. Cervical dentin hypersensitivity was assessed at baseline, immediately, 24 hours and 30 days after the treatment. Cold and evaporative tests were used to assess the sensitivity level.

Official Title
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Clinical Evaluation of the Effectiveness of Immediate Relief Obtained With Desensitizing Creams - A Controlled, Randomized, Triple Masked, Split-Mouth Clinical Trial

Conditions
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Dentine Hypersensitivity

Intervention / Treatment
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* Procedure: Colgate
* Procedure: Sensodyne
* Procedure: Nano P
* Procedure: Cocorico


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: subjects 18 years or older in good general and oral health; have complaint of CDH in teeth distributed in all 4 quadrants not making use of desensitizing agents not having undergone periodontal treatment over the past 3 months respond to evaporative stimulus with a score ≥ 1.5 cm on VAS Exclusion Criteria: patients who presented restorations and caries near the exposed dentin of the hypersensitive teeth who made frequent use of painkillers, anti-inflammatory and antidepressants drugs

Ages Eligible for Study
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Minimum Age: 22 Years
Maximum Age: 48 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Sensodyne<br>Digital application for 60 seconds. | Procedure: Sensodyne<br>* Digital application for 60 seconds.<br>|
| Experimental: Colgate<br>Slow-speed handpiece with a Robson brush for 3 seconds by repeating the procedure | Procedure: Colgate<br>* Slow-speed handpiece with a Robson brush for 3 seconds by repeating the procedure<br>|
| Experimental: Nano P<br>Slow-speed handpiece with a Robson brush for 10 seconds | Procedure: Nano P<br>* Slow-speed handpiece with a Robson brush for 10 seconds<br>|
| Placebo Comparator: Cocorico<br>Digital application for 60 seconds | Procedure: Cocorico<br>* Digital application for 60 seconds<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| cervical dentin hypersensitivity | The cervical dentin hypersensitivity was evaluated by an air blast (evaporative stimulus) for 5 seconds, and by a tetrafluoroethane spray (cold stimulus) for 5 seconds. | 30 days |