Optical Coherence Tomography of Nerve Fiber Layer and Ganglion Cell Complex After Cataract Extraction

Study Overview
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Brief Summary
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Optical coherence tomography (OCT) for retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) is done before and after cataract extraction in patients with or without primary open angle glaucoma (POAG)

Detailed Description
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The investigator's study includes two groups of patients, each consists of 25 eyes, group 1 (cataract group)includes patients who are planned for cataract extraction without any other preexisting retinal or optic nerve pathology that may affect the RNFL thickness, while group 2 (combined cataract and glaucoma group) includes patients who are diagnosed with POAG controlled on medical treatment with cataract and planned for cataract extraction only. The OCT scans with complete ophthalmological examination are done before surgery and 6 weeks after uneventful cataract extraction (phacoemulsification with intraocular lens implantation)

Official Title
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Comparison Between OCT Nerve Fiber Layer and Ganglion Cell Complex Parameters Following Cataract Extraction in Patients With or Without Primary Open Angle Glaucoma

Conditions
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Cataract, Primary Open-angle Glaucoma

Intervention / Treatment
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* Diagnostic Test: Oct scans


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: • patients with cataract without any other concomitant retinal, optic nerve head pathology other than POAG are included in the study and divided onto two groups Exclusion Criteria: Patients having any retinal or optic nerve pathology that might have affected nerve fiber layer thickness other than POAG eg: high myopia POAG patients who are planned for combined surgery Refractive errors greater than spherical equivalent of 6 diopters (myopia or hypermetropia) Dense cataract hindering OCT imaging History of previous ocular surgery or trauma

Ages Eligible for Study
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Minimum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cataract group<br>Group 1 includes patients who are planned for cataract extraction without any other preexisting retinal or optic nerve pathology that may affect the RNFL thickness. OCT (investigation) before and after cataract extraction | Diagnostic Test: Oct scans<br>* Oct scans to assess thickness of RNFL and GCC before and after cataract extraction surgery in both groups<br>|
| Combined cataract and glaucoma group<br>Group 2 includes patients who are diagnosed with POAG controlled on medical treatment and have cataract and planned for cataract extraction only OCT is done before and after cataract extraction | Diagnostic Test: Oct scans<br>* Oct scans to assess thickness of RNFL and GCC before and after cataract extraction surgery in both groups<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| RNFL and GCC thickness | Assessment of RNFL and GCC thickness change after cataract extraction | Oct scans before and 6 weeks after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Final best corrected visual acuity (BCVA) | Assessment of the final BCVA recorded according to the Snellen chart and converted to logMAR for statistical analysis | Six weeks after cataract surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Retinal nerve fiber layer (RNFL), Ganglion cell complex (GCC), Optical coherence tomography (OCT), Primary open angle glaucoma (POAG), Cataract