Lornoxicam Versus Etodolac After Third Molar Surgery

Study Overview
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Brief Summary
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Our study aimed to compare the effect of lornoxicam and etodolac on postoperative pain, edema and trismus following lower third molar extraction

Detailed Description
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20 patients included in study (4 male, 16 female). Lornoxicam and etodolac was given following lower third molar extraction. Pain was evaluated 2., 6., 12., 24., and 48. hours using VAS. Edema was evaluated by measuring tragus-labial commissure, angulus- lateral canthus of eye and angulus mandible-labial commissure. Trismus was evaluated measuring mouth opening by caliper. Edema and Trismus was evaluated by 48. and 168. hours

Official Title
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Comparison of Lornoxicam and Etodolac on Edema, Trismus and Pain After Third Molar Surgery

Conditions
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Pain, Acute, Edema, Trismus

Intervention / Treatment
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* Drug: Lornoxicam 8 Mg Oral Tablet


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Bilateral mesioangular impacted lower third molar Asymptomatic Third Molar (No history of infection) Systemically Healthy Person Person Between aged 18-30 Exclusion Criteria: People who are pregnant and lactation process People who had any systemic disease People who are gastrointestinal problems People who are sensitive to drugs used in study Lower Third Molar associated with cysts and infections

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 30 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Sequential Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Etodolac<br>Etodolac, 400 mg tid per a day for four days | Drug: Lornoxicam 8 Mg Oral Tablet<br>* Lornoxicam is a oxicam grup non-steroid antiinflamatuar drug<br>* Other names: Etodolac;|
| Active Comparator: Lornoxicam<br>Lornoxicam, 8 mg twice per day for four days | Drug: Lornoxicam 8 Mg Oral Tablet<br>* Lornoxicam is a oxicam grup non-steroid antiinflamatuar drug<br>* Other names: Etodolac;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain after wisdom tooth extraction | Pain after lower third molar removal, Pain was evaluated with VAS(visual anolog scale) | 2 th hours | 
| Edema after wisdom tooth extraction | Edema lower third molar removal, Edema was evaluated by using reference line on the face | 48 th hours | 
| Trismus after wisdom tooth extraction | Trismus lower third molar removal, trismus was evaluated by using caliper | 48 th hours, | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain after wisdom tooth extraction | Pain after lower third molar removal, Pain was evaluated with VAS(visual anolog scale) | 6 th hours | 
| Pain after wisdom tooth extraction | Pain after lower third molar removal, Pain was evaluated with VAS(visual anolog scale) | 12 th hours | 
| Pain after wisdom tooth extraction | Pain after lower third molar removal, Pain was evaluated with VAS(visual anolog scale) | 24 th hours | 
| Pain after wisdom tooth extraction | Pain after lower third molar removal, Pain was evaluated with VAS(visual anolog scale) | 48 th hours | 
| Edema after wisdom tooth extraction | Edema lower third molar removal, Edema was evaluated by using reference line on the face | 168 th hours | 
| Trismus after wisdom tooth extraction | Trismus lower third molar removal, trismus was evaluated by using caliper | 168 th hours |