Comparison of Treatment Effect of Chinese Medicine and Western Medicine on Depression in China and America

Study Overview
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Brief Summary
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Comparison of different assessment methods to evaluate the treatment efficacy of Chinese medicine on minor and mild depression.

Detailed Description
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Significant differences show on the evaluation of treatment efficacy of Chinese medicine on depression in China and America. Choose minor and mild depression patients as trials. One hundred and sixty trials will be included and randomly divided into Chinese medicine group (n=40), acupuncture group (n=40), traditional Chinese medicine psychology group (n=40) and physical treatment group (n=40). Time points of assessment are before treatment, 1 week, 2 weeks, 4weeks, 6 weeks and 12 weeks post treatment.The assessment tools are series of psychological questionnaires. And study the mechanism of treatment efficacy assessment variances by different methods.

Official Title
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Comparison of Treatment Effect of Chinese Medicine and Western Medicine on Depression in China and America

Conditions
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Depression

Intervention / Treatment
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* Drug: Chinese herbs
* Procedure: acupuncture
* Other: Psychotherapy
* Device: Transcranial magnetic stimulation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: According with ICD-10 criteria of depression; Age 16-70; Antidepressant and other Psychiatric drugs have not been had two weeks before the trial, or the drugs above had been used but have cleaning period of two weeks; Level of education is higher than junior middle school; Course of disease is more than two weeks; Volunteer to join and Signed the informed consent Exclusion Criteria: Pregnancy or lactation; Severe depression or have serious suicidal tendencies long distance or other causes who can not adherence to treatment

Ages Eligible for Study
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Minimum Age: 16 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Chinese herb<br>Chinese herbs special for depression | Drug: Chinese herbs<br>* Chinese herbs special for depression<br>|
| Experimental: acupuncture<br> | Procedure: acupuncture<br>* six acupuncture point including DU20, EX HN3, EX HN1, PC6,HT7,SP6,special for depression<br>|
| Experimental: Psychotherapy<br> | Other: Psychotherapy<br>* Thought Imprint Psychotherapy under lower Resistance State<br>|
| Experimental: physiotherapy<br> | Device: Transcranial magnetic stimulation<br>* Give magnetic stimulation at head<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| psychological questionnaires |  | 12 weeks post treatment. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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depression, Chinese herb, acupuncture, Psychotherapy, Transcranial magnetic stimulation