linjc16/ctgov huggingface dataset:
Triggering of Follicular Maturation

Study Overview
=================
Brief Summary
-----------------
The follicular phase of the menstrual cycle involves the hourly release of gonadotropin-releasing hormone, which binds to receptors on the gonadotropes. This results in the secretion of follicle stimulating hormone and luteinizing hormone in hourly pulses that regulate follicular growth. At midcycle, rapidly rising estradiol from the dominant follicle and a small rise in progesterone lead to a gonadotrophic surge. An increase in the amplitude of Luteinizing hormone and Follicle stimulating hormone pulses initiates oocyte maturity and triggers ovulation approximately

Official Title
-----------------
Triggering of Follicular Maturation Using Human Chorionic Gonadotrophin With Gonadotrophin Releasing Hormone Agonist Versus Human Chorionic Gonadotrophin Alone in Antagonist Protocol in Assisted Reproductive Technology : a Randomized Controlled Trial

Conditions
-----------------
Increase Pregnancy Rate

Intervention / Treatment
-----------------
* Drug: Recombinant Human Chorionic Gonadotrophin
* Drug: human chorionic gonadotrophin + gonadotrophin releasing hormone agonist


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Infertile couples wishing to do intracytoplasmic injection trial . first intracytoplasmic injection trial Body mass index:18-30. 5-Antral follicular count: more than 5 follicles in one ovary 6-normal, mild or moderate male factor infertility. 7- Antimullerian hormone >1 ng/ml Exclusion Criteria: Azoospermic male. Body mass index more than 29. Patients with endometriosis . Antimullerian hormone < 1 ng/ml

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Human chorionic gonadotrophin group<br>Patients will receive Human chorionic gonadotrohpin injection 5000 unit | Drug: Recombinant Human Chorionic Gonadotrophin<br>* 250 unit intramuscular<br>* Other names: Ovitrelle;|
| Active Comparator: Human chorionic gonadotrophin + agonist group<br>patients will receive both Human chorionic gonadotrophin (2500 unit) and gonadotrophin releasing hormone agonist 1mg leuprolide acetate | Drug: human chorionic gonadotrophin + gonadotrophin releasing hormone agonist<br>* 250 unit intramuscular + 1 mg subcutaneous<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of M II oocytes in both groups |  | 24 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fertilization rate in each group |  | 3 days | 
| Clinical pregnancy rate in each group |  | 15 days |
Parental Perception of Child's Weight and Childhood Obesity

Study Overview
=================
Brief Summary
-----------------
The increasing prevalence of metabolic diseases requires new strategies in the treatment and prevention of obesity. Children exposed to a poor diet and a sedentary lifestyle are especially vulnerable and may therefore be at risk of obesity at a very early stage in their lives. Recent studies have indicated a notable misperception of children's weight by parents. The main objective of this project is to study the association between parental perception of child's body weight and 1) feeding practices (permissive, restrictive or model); and 2) child's degree of overweight.

Official Title
-----------------
Relationship Between Parental Perception of Child's Weight and Feeding Practices in the Context of Childhood Obesity: The PERCEPS Study

Conditions
-----------------
Childhood Obesity, Diet Habit

Intervention / Treatment
-----------------
* Other: Cross-sectional


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Willing to participate Exclusion Criteria: -

Ages Eligible for Study
-----------------
Minimum Age: 4 Years
Maximum Age: 8 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| School<br> | Other: Cross-sectional<br>* No intervention<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Infant feeding practices measured by the Child Feeding Practice questionnaire | We will assess three factors from the Child Feeding Practice (CFP) questionnaire measuring parental control practices and attitudes regarding child feeding: Restriction (8 items), Pressure to eat (4 items), and monitoring (3 items). Each item is scored from 1 to 5, and the mean value for each factor will be calculated. | Baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Participant BMI z-score | Weight and height of participants will be measured and combined to calculate the BMI z-score based on the WHO growth charts | Baseline |
Far Infrared Treatment for Kidney Diseases

Study Overview
=================
Brief Summary
-----------------
Renal failure or kidney failure is a situation in which the kidneys fail to function adequately. It is divided into acute and chronic forms; either form may be due to a large number of other medical problems.

Detailed Description
-----------------
There are many causes of chronic kidney disease. The most common cause is diabetes mellitus. Acute renal failure is a rapidly progressive loss of renal function, generally characterized by body fluids disturbances and electrolyte derangement. It is believed that far infrared radiation of the central nervous system, the endocrine system and the kidneys will help in the management of renal failure and a possible cure.

Official Title
-----------------
Phase 1 Study to Examine the Use of Far Infrared Radiation for Renal Failure.

Conditions
-----------------
Kidney Failure

Intervention / Treatment
-----------------
* Radiation: Far Infrared Radiation (5μm to 20μm wavelength)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: People with kidney diseases Exclusion Criteria: None
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: 1<br>Far Infrared Radiation | Radiation: Far Infrared Radiation (5μm to 20μm wavelength)<br>* Far Infrared Radiation for 30 to 40 minutes per session.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Kidney Function Improvement |  | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Causes of Mortality |  | 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
KIDNEY FAILURE, ACUTE, KIDNEY FAILURE, CHRONIC, RENAL INSUFFICIENCY
Assessing the Utility of Ultrasound Compared to Cross-Sectional Imaging in the Follow-up of Patients With Renal Cell Carcinoma

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to determine the utility of renal ultrasonography (US) in the detection of abdominal recurrences after definitive therapy for renal cell carcinoma (RCC) and compare the detection rate to that of cross-sectional imaging.

Official Title
-----------------
Assessing the Utility of Ultrasound Compared to Cross-Sectional Imaging in the Follow-up of Patients With Renal Cell Carcinoma

Conditions
-----------------
Renal Cell Carcinoma

Intervention / Treatment
-----------------
* Diagnostic Test: Ultrasonography


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients must be 18 year of age or older. Patients having undergone radical or partial nephrectomy for the indication of renal cell carcinoma. Most recent imaging study must have been either computed tomography (CT) or magnetic resonance imaging (MRI). Exclusion Criteria: Patients with pT4 disease (tumor invades beyond the Gerota fascia: including contiguous extension into the ipsilateral adrenal gland). Patients with metastatic disease prior to time of surgery requiring systemic treatment. Patients with another active cancer diagnosis requiring systemic treatment. Patients with contrast allergies. Patients with baseline chronic kidney disease (GFR < 45 ml/min/1.73 m2).

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Ultrasonography<br>Patient will be scheduled to undergo an additional US by a blinded sonographer within 4 weeks of their most recent cross-sectional imaging that indicated a recurrence | Diagnostic Test: Ultrasonography<br>* Abdominal Ultrasonography<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Utility of Renal Ultrasonography (US) in the detection of abdominal recurrences | Renal Cell Carcinoma (RCC) recurrence detection of ultrasonography in patients who have undergo definitive therapy for RCC compared to detection rate of cross-sectional imaging | 4 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Radiation Burden | Compare the average radiation exposure over 5 years for patients on current standard of care imaging surveillance for RCC, which consists of both ultrasound and cross-sectional imaging, to that of patients who would only receive cross-section imaging surveillance for RCC. This would yield overall increase in radiation burden for patients with RCC | 5 years |
Stenting With or Without Coating Compared With Angioplasty in Non-benestent Disease

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate the clinical and angiographic outcome of implantation of stents eluting or not eluting Sirolimus in patients with complex coronary artery lesions suitable for percutaneous coronary intervention.

Official Title
-----------------
Stenting With or Without Coating Compared With Angioplasty in Non-benestent Disease. A Randomised Comparison of Optimal Balloon Angioplasty and Primary Implantation of Stents With and Without Drug Elution in Complex Coronary Lesions

Conditions
-----------------
Coronary Artery Disease

Intervention / Treatment
-----------------
* Device: Bx Sonic & Cypher stent from Cordis


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Stable, or unstable angina and/or objective signs of myocardial ischaemia Informed consent Optimal result (< 35% residual stenosis and < type C dissection) after balloon angioplasty Lesions should be de novo and located in native vessels with a diameter > 2.25 mm. Complex lesions to be included should have at least one of the following characteristics: ostial in location (< 5 mm from ostium) total occlusions with a length ≥ 15 mm bifurcational (side branch > 1.75 mm in diameter) angulated (> 45° within lesion) Exclusion criteria: Patients: Other severe disease with an expected survival < 1 year Other significant cardiac disease Known allergy against paclitaxel, clopidogrel (or ticlopidine), Myocardial infarction within 3 days of the index procedure Linguistic difficulties needing an interpreter Renal insufficiency (p-creatinine > 200 micromol/l) Gastrointestinal bleeding within 1 month Childbearing potential or pregnancy Participation in another study Lesions: Unprotected left main disease Restenosis Lesions containing visible thrombus Treatment with other modality than balloon or stent (ablation, brachytherapy, ultrasound) in connection with the index procedure Diffuse coronary disease distal to the treated lesion Heavily calcification Lesion located in saphenous vein graft

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: Bx Sonic & Cypher stent from Cordis|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Percutaneous coronary intervention, Balloon angioplasty, Restenosis, Stents
Therapeutic Follow-up of Antibiotics in Pediatric Intensive Care

Study Overview
=================
Brief Summary
-----------------
Currently, recommendations for antibiotic testing (ATS) in adult intensive care have been published. The 2018 SFAR and the Abdul- Aziz et al expert conference recommend routine testing for β-lactams, aminoglycosides, linezolid, and vancomycin and provide plasma concentration goals. No recommendations have been made for the pediatric intensive care unit (PICU) population. However, several articles report suboptimal plasma concentrations for the most frequently used antibiotics in PICU. The University Hospital of Reunion is the reference center for the western region of the Indian Ocean. This region presents a large mixed population due to the migratory flow, as well as a specific bacterial ecology. This suggests that the data already collected on antibiotic dosage in other European studies may not be fully extrapolated to Reunion Island. It is in this context that we will study the plasma concentration of antibiotics for all children who received the most commonly used antibiotics (β-lactams, linezolid, vancomycin, and aminoglycosides) during their hospitalization in PICU.

Official Title
-----------------
Therapeutic Follow-up of Antibiotics in Pediatric Intensive Care

Conditions
-----------------
Intensive Care Units, Pediatric

Intervention / Treatment
-----------------
* Other: Antibiotics Dosing


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Any child hospitalized in the pediatric intensive care unit of the CHU Nord de La Réunion, Age is less than 18 years, Having started a curative antibiotic therapy by β-lactam, linezolid, vancomycin or aminosides. For whom a non-opposition has been collected orally from both or one of the child's legal guardians and from the child himself (if applicable), Covered by Social Security. Exclusion Criteria: -Patients on prophylactic antibiotic therapy

Ages Eligible for Study
-----------------
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Antibiotics Dosing|Dosing concerns the main antibiotics used in the unit: b-lactams, linezolid, vancomycin and aminosides|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The occurrence of at least one underdosing event of one of the Antibiotics used in a patient included during his or her hospitalization in pediatrics intensive care unit (PICU) | Underdosing is defined as a measurement of plasma concentration below the optimal therapeutic concentration (OTC) | 2 months |
The Effect of Ketamine on Postoperative Cognitive Dysfunction.

Study Overview
=================
Brief Summary
-----------------
Available evidence suggests that there is no significant difference in the incidence of postoperative cognitive dysfunction POCD when general anaesthesia and regional anaesthesia are compared[13, 14]. To the knowledge of the investigators , no studies are examining the effects of ketamine on cognitive outcomes in the setting of spinal anesthesia. Thus, the purpose of this study was to compare the cognitive status, as assessed by the SPMSQ, of elderly patients undergoing orthopaedic surgery under spinal anaesthesia before and after ketamine administration. The authors hypothesized that patients receiving ketamine would exhibit better cognitive performance.

Official Title
-----------------
The Effect of Ketamine on Postoperative Cognitive Dysfunction in Geriatric Patients Undergoing Orthopaedic Surgery Under Spinal Anaesthesia, a Randomized Controlled Trial

Conditions
-----------------
Postoperative Cognitive Dysfunction

Intervention / Treatment
-----------------
* Drug: Ketamine
* Other: Placebo


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients scheduled for orthopaedic surgery under spinal anaesthesia. ASA physical status I to II. Exclusion Criteria: Patients with a history of psychosis, schizophrenia, nephropathy, uncontrolled blood pressure, uncontrolled hepatic disorders, or allergy to ketamine. Patients With moderate to severe depression according to Yesavage abbreviated Geriatric Depression Scale, Patients presented with postoperative delirium or required medications other than study drugs. Ketamine administration is contraindicated.

Ages Eligible for Study
-----------------
Minimum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Ketamine<br> | Drug: Ketamine<br>* ketamine will be administered at a dose of 0.3 mg/kg in normal saline at 0.9% (250 mL)<br>|
| Placebo Comparator: Control<br> | Other: Placebo<br>* the control group will receive only normal saline at 0.9%, with the same physical characteristics of the ketamine solution<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| postoperative cognitive dysfunction | cognitive status will be conducted with the Short Portable Mental Status Questionnaire SPMSQ preoperative and 2 hours after surgery. | first postoperative day |
Noninvasive Estimation of Work of Breathing

Study Overview
=================
Brief Summary
-----------------
This study will evaluate the correlation between invasively measured parameters (work of breathing/power of breathing, resistance and elastance), derived using esophageal pressure measurements, and their corresponding non-invasive estimated values (noninvasive work of breathing/power of breathing, resistance and elastance), computed using airway pressure and flow measurements only.

Detailed Description
-----------------
This study will evaluate the correlation between invasively measured parameters (work of breathing/power of breathing, resistance and elastance), derived using esophageal pressure measurements, and their corresponding non-invasive estimated values (noninvasive work of breathing/power of breathing, resistance and elastance), computed using airway pressure and flow measurements only. Vent settings will be adjusted to test accuracy over a range of respiratory support conditions.

Official Title
-----------------
Noninvasive Estimation of Work of Breathing

Conditions
-----------------
Acute Respiratory Distress Syndrome

Intervention / Treatment
-----------------
* Other: changes in ventilator settings


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adult medical/surgical ICU patients (Age≥18) on mechanical ventilation for respiratory failure, spontaneously breathing and receiving eligible for pressure support ventilation (PSV). Exclusion Criteria: Prisoners and patients with closed-head injury (e.g., trauma), hemodynamic instability, multiple organ system failure or late term pregnancy will not be studied.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Single Observational Group<br>Patients receiving mechanical ventilation and subject to the intervention: changes in ventilator settings. | Other: changes in ventilator settings<br>* Ventilator settings will be adjusted (vent mode, pressure support/control level, cycling, inspiratory time, mandatory rate).<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Accuracy of lung mechanics measurements |  | Immediate |