Resolvin D1 Levels in Patients With Periodontitis

Study Overview
=================
Brief Summary
-----------------
The purpose of the study was to determine the levels of Resolvin D1 (RVD1) in the gingival crevicular fluid (GCF) and saliva of the patients with periodontitis (P) and also to investigate the effects of non-surgical periodontal treatments (NSPTs) on its levels. A total of 26 subjects (15 P, 11 healthy) were included. Clinical periodontal measurements, GCF and saliva samples were collected from each individual at baseline and 1 month after NSPTs in P group. RVD1 levels were determined by enzyme-linked immunosorbent assay (ELISA) method.

Official Title
-----------------
The Role of Resolvin D1 in Maintaining Oral Health

Conditions
-----------------
Periodontitis

Intervention / Treatment
-----------------
* Procedure: periodontal therapy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Stage 3, Grade B and generalized periodontitis patients Exclusion Criteria: excessive forces; presence of systemic diseases administration of non-steroidal and anti-inflammatory drugs or antibiotic therapies within the previous 6 months having received non-surgical periodontal treatment within the past 6 months allergy or sensitivity to any drug, pregnancy, lactation current and former use of tobacco.

Ages Eligible for Study
-----------------
Minimum Age: 30 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Periodontitis patients<br>gingival crevicular fluid and saliva collection were taken before and after nonsurgical periodontal treatment | Procedure: periodontal therapy<br>* Non surgical periodontal therapy was performed to patients with peridontitis<br>|
| No Intervention: Healthy individuals<br>gingival crevicular fluid and saliva collection were taken at baseline after oral hygiene instructions | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Biochemical parameter (resolvin D1) | The changes in levels of resolvin D1 after periodontal treatment determined by ELISA. | Baseline and 1 month after NSPT | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Probing pocket depth | The changes in probing pocket depth after periodontal treatment were evaluated | Baseline and 1 month after NSPT | 
| Clinical attachment level (CAL) | The changes in CAL after periodontal treatment were evaluated | Baseline and 1 month after NSPT | 
| Plaque index (PI) | The changes in PI after periodontal treatment were evaluated | Baseline and 1 month after NSPT | 
| Gingival index (GI) | The changes in GI after periodontal treatment were evaluated | Baseline and 1 month after NSPT | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
gingival crevicular fluid, resolvin D1