The Impact of Exercise on Hand Function, Daily Activities Performance and Quality of Life of SLE' Patients

Study Overview
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Brief Summary
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A total of 240 consecutive SLE patients fulfilling the SLICC classification criteria was evaluated. Sixty two patients who met the inclusion criteria were randomly assigned to the exercise group (n=32) or the control group (n=30). Patients in the exercise group performed a program of strengthening, stretching and resistance upper limbs exercises, of 30 minutes duration daily, for 12 weeks. Performance of daily activities was evaluated with the DASH and HAQ questionnaires, grip and pinch strength with the Jamar dynamometer and pinch gauge tools respectively, dexterity with the Purdue pegboard test and the quality of life with the LUPUSQoL questionnaire at 0, 6, 12 (end of the exercise program) and 24 weeks for both groups. SLE activity and cumulative organ damage were evaluated with the SLE disease activity index 2000 (SLEDAI-2K) and SLICC/ACR-DI, respectively.

Detailed Description
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A total of 240 consecutive SLE patients fulfilling the SLICC classification criteria was evaluated. Sixty two patients who met the inclusion criteria [age>18, upper limb arthralgias, and DASH (Disabilities of the Arm, Shoulder, and Hand) questionnaire score>10)] were randomly assigned to the exercise group (n=32) or the control group (n=30). Patients in the exercise group performed a program of strengthening, stretching and resistance upper limbs exercises, of 30 minutes duration daily, for 12 weeks. Performance of daily activities was evaluated with the DASH and HAQ questionnaires, grip and pinch strength with the Jamar dynamometer and pinch gauge tools respectively, dexterity with the Purdue pegboard test and the quality of life with the LUPUSQoL questionnaire at 0, 6, 12 (end of the exercise program) and 24 weeks for both groups. SLE activity and cumulative organ damage were evaluated with the SLE disease activity index 2000 (SLEDAI-2K) and SLICC/ACR-DI, respectively.

Official Title
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The Impact of Exercise on Hand Function, on Activities of Daily Living (ADLs) Performance and Quality of Life of Patients With Systemic Lupus Erythematosus (SLE)

Conditions
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Systemic Lupus Erythematosus, Arthralgia

Intervention / Treatment
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* Behavioral: HAND EXERCISE


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: SLE patients fulfilling the SLICC classification criteria Upper limb arthralgias DASH score>10 Stable drug regimen≥3 months Exclusion Criteria: Hand fracture or surgery in last 6 months Physiotherapy program in last month

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: EXERCISE GROUP<br>Patients in the exercise group performed a program of strengthening, stretching and resistance upper limbs exercises (Hand exercise), of 30 minutes duration daily, for 12 weeks in addition to medical care. | Behavioral: HAND EXERCISE<br> <br> |
| No Intervention: CONTROL GROUP<br>Patients in the control group continued their usual medical care. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change of DASH questionnaire | Hand function was measured with DASH Questionnaire | Baseline, 6, 12, 24 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change of HAQ questionnaire | Hand function was measured with HAQ Questionnaire | Baseline, 6, 12, 24 weeks | 
| change of Grip strength | Grip strength was measured with Jamar Dynamometer | Baseline, 6, 12, 24 weeks | 
| change of Pinch strength | Pinch strength was measured with Jamar pinch gauge | Baseline, 6, 12, 24 weeks | 
| change of Dexterity | Dexterity was measured with Purdue Pegboard test | Baseline, 6, 12, 24 weeks | 
| change of Quality of Life | Quality of Life was measured with LupusQoL Questionnaire | Baseline, 6, 12, 24 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Exercise, Hand function, Quality of Life