Recurrence Rate, Risk Factors for the Recurrence, and Quality of Life in Patients With GERD in Korea-an Observational

Study Overview
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Brief Summary
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Recurrence rate, risk factors for the recurrence, and quality of life in patients with GERD in Korea-an observational study.

Official Title
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Recurrence Rate, Risk Factors for the Recurrence, and Quality of Life in Patients With GERD in Korea-an Observational Study

Conditions
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The Aim of This Study is to Investigate the Frequency and Related Risk Factors of Recurrence, and Quality of Life in Patients With GERD After Treatment With PPI

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Both ERD or NERD patient who confirmed by EGD findings within 12 months prior to V1 and have a symptom with moderate or more, at least once per week within 1 week prior to V1 and Patients between age 20 and 80with typical reflux symptoms Among the patient who have not taken PPI or H2 blocker within 4 weeks prior to V1, needs to be prescribed PPIs 4 8 weeks as a part of the routine clinical practice due to typical symptom Patients who give the signed informed consent Exclusion Criteria: Patients with past history of gastrointestinal surgery Patients with known malignancy or history of such diseases Patients with moderate to severe general medical conditions like ischemic heart disease, chronic renal failure, congestive heart failure, COPD, liver cirrhosis, acute or chronic pancreatitis, or other medical conditions which the investigator considers

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Typical reflux symptom by EGD<br>Total 2000 subjects who has Typical reflux symptom by EGD | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of recurrence after treatment with PPI in patients with GERD |  | 12month | 
| Response rate to the treatment with PPI in patients with GERD |  | 12month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Baseline characteristics related to the recurrence of GERD |  | 12month | 
| Rate of complete resolution in each group of patients with ERD or NERD |  | 12month | 
| Rate of recurrence in each group of patients with ERD or NERD |  | 12month | 
| Quality of life measured by EQ-5D and WPAI-GERD in each group of patients with ERD or NERD |  | 12month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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GERD, Comparison between ERD and NERD, Rate of complete resolution, rate of recurrence, QOL, To investigate the frequency and related risk factors of recurrence, and quality of life in patients with GERD after treatment with PPI, The aim of this study is to investigate the frequency and related risk factors of recurrence, and quality of life in patients with GERD after treatment with PPI