linjc16/ctgov huggingface dataset:
Response of Continuous Recombinant Antithrombin Infusion in Postcardiotomy ECMO Patients

Study Overview
=================
Brief Summary
-----------------
The objective of this study will be to prospectively evaluate the response of a continuous infusion of recombinant human antithrombin concentrate (rhAT) (ATRYN®) to achieve and maintain the AT activity within a specified range in adult patients that require extracorporeal membrane oxygenation (ECMO) following cardiopulmonary bypass (CPB) and cardiac surgery.

Official Title
-----------------
A Pilot Study, Prospective, Non-Randomized, Non-Blinded, Single-Center Study Evaluating the Response of Continuous Recombinant Antithrombin (ATryn) Infusion in Postcardiotomy ECMO Patients

Conditions
-----------------
Antithrombin Deficiency Type 2

Intervention / Treatment
-----------------
* Drug: ATryn continuous infusion


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Completed cardiac surgery with Cardiopulmonary Bypass and subsequently placed on venoarterial (VA) Extracorporeal Membrane Oxygenation (ECMO) support at any point during the ongoing hospitalization Serum Antithrombin < 60%. Exclusion Criteria: Heart transplantation during ongoing hospitalization Excessive bleeding (300 ml/hr of chest tube drainage for 2 consecutive hours) Weight < 40 kg Allergy to goat products Anticoagulation with a direct thrombin inhibitor Religious exception to blood products Hypothermia (< 34°C)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Infusion group<br>Subjects will receive ATryn continuous infusion for maintaining serum antithrombin III levels between 80 - 100 | Drug: ATryn continuous infusion<br>* replenish serum thrombin levels<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percentage of time within the serum AT level target range of 80-100% | Target value of Antithrombin is recorded as % | 72 hour infusion period |
Assessment Of Anterior Chamber Configuration Changes After Phacoemulsification

Study Overview
=================
Brief Summary
-----------------
To investigate changes in anterior chamber angle configuration after phacoemulsification and intraocular lens (IOL) implantation with Swept-Source Optical Coherence Tomography (SS-OCT).

Detailed Description
-----------------
To investigate changes in anterior chamber angle configuration after phacoemulsification and intraocular lens (IOL) implantation in eyes with a shallow anterior chamber and narrow angle, compared with the eyes with normal anterior chamber and open angle using Swept-Source Optical Coherence Tomography (SS-OCT).

Official Title
-----------------
To Investigate Changes in Anterior Chamber Angle Configuration After Phacoemulsification

Conditions
-----------------
Cataract, Shallow Anterior Chamber, Narrow Angle

Intervention / Treatment
-----------------
* Procedure: cataract surgery


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: ACD was less than 2.68mm. the anterior chamber angle width on gonioscopy≤Shaffer 2 . Exclusion Criteria: primary or secondary glaucoma, peripheral anterior synechiae, history of ocular surgeries

Ages Eligible for Study
-----------------
Minimum Age: 45 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| normal angle<br>normal anterior chamber and open angle eyes underwent cataract surgery | Procedure: cataract surgery<br>* The patients of both groups underwent cataract surgery<br>|
| narrow angle<br>shallow anterior chamber and narrow angle eyes underwent cataract surgery | Procedure: cataract surgery<br>* The patients of both groups underwent cataract surgery<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| anterior chamber angle parameters increased |  | 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
shallow anterior chamber, narrow angle, SS-OCT
HIV, Abuse, and Psychiatric Disorders Among Youth

Study Overview
=================
Brief Summary
-----------------
One subgroup of adolescents at particular risk for HIV is those with psychiatric disorders. Furthermore, those with histories of sexual abuse have been found to have riskier attitudes, poorer sexual communication skills, and less consistent condom use than non-abused peers. This study implemented and evaluated interventions for adolescents in intensive psychiatric treatment settings, particularly those with histories of sexual abuse. It is hypothesized that those participating in the intervention that addresses affect management and cognitive monitoring strategies will show fewer HIV-risk related behaviors and attitudes at posttest than peers in an information-based intervention.

Official Title
-----------------
HIV, Abuse, and Psychiatric Disorders Among Youth

Conditions
-----------------
HIV Infections

Intervention / Treatment
-----------------
* Behavioral: group intervention
* Behavioral: group intervention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adolescent attending therapeutic school Exclusion Criteria: Adolescent is HIV positive Adolescent is developmentally delayed Adolescent is pregnant Adolescent has a history of sexual crime

Ages Eligible for Study
-----------------
Minimum Age: 13 Years
Maximum Age: 19 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>13 session group intervention including sexual health information, affect management skills, cognitive monitoring, and communication skills training. | Behavioral: group intervention<br>* 13-session intervention<br>|
| Active Comparator: 2<br>2 session group intervention including sexual health information training. | Behavioral: group intervention<br>* 2-session intervention<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| condom use |  | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| scores on HIV knowledge questionnaire |  | 1 year | 
| number of sexual partners |  | 1 year | 
| scores on measure of attitudes toward condom use |  | 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
HIV prevention, HIV seronegativity
Sleep Quality Among HCWs

Study Overview
=================
Brief Summary
-----------------
The novel coronavirus has brought the world into uncharted waters. Whole countries are on lockdown, the economy has ground to a halt, and many people are afraid for themselves and their loved ones. With such unprecedented changes coming on so quickly, it's understandable that the importance of sleep is flying under the radar. But as we adjust to stay-at-home orders and try to remain healthy in a time of COVID-19, focusing on sleeping well offers tremendous benefits. Millions of people suffered from insomnia before the coronavirus, and unfortunately, the pandemic creates a host of new challenges even for people who previously had no sleeping problems. The coronavirus pandemic doesn't affect everyone in the same way. Of course, patients with the virus and front-line medical workers face the brunt of the direct impacts of the disease. Social distancing, school closures, quarantines, working-from-home: all bring profound changes to normal routines for people of all ages and walks of life. The aim of the current work is to assess the sleep quality among health care workers in the front-line management of COVID-19 in Kuwaiti Ministry of Health hospitals and its relation on medical errors.

Official Title
-----------------
Sleep Quality Among Health Care Workers During COVID-19 Pandemic: Kuwait Experience

Conditions
-----------------
Sleep Quality

Intervention / Treatment
-----------------
* Other: PSQI


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: -Health care workers at Kuwait Ministry of Health hospitals during the period from May 2020 to July 2020 Exclusion Criteria: Care givers above 60 years those who refuse to participate or requested to withdraw from the study at any time HCWs who were not on duty at the time of survey due to any leave or absence replies with incomplete answers or duplicate answers

Ages Eligible for Study
-----------------
Minimum Age: 25 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: PSQI|Assessment of sleep quality using Pittsburgh Sleep Quality Index (PSQI): It is a simple tool which assess the sleep quality over one month period. It included seven components with a global PSQI score > 5 is indicative of poor sleep quality|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Presence of poor sleep quality or not | survey | one month period | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| reported medical errors | survey | one month |
Effects of Prior Induced Termination of Pregnancy on Complications and Pregnancy Outcomes.

Study Overview
=================
Brief Summary
-----------------
A prospective multicenter cohort study to evaluate effects of prior induced termination of pregnancy on complications and pregnancy outcomes.

Detailed Description
-----------------
A prospective multicenter cohort study to evaluate effects of prior induced termination of pregnancy on complications and pregnancy outcomes.

Official Title
-----------------
Effects of Prior Induced Termination of Pregnancy on Complications and Pregnancy Outcomes.

Conditions
-----------------
Reproductive Health

Intervention / Treatment
-----------------
* Procedure: induced termination of pregnancy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: women have induced abortion in early pregnancy (<12 weeks of gestation). permanent population and no tendency to move. normal language expression and understanding ability, able to understand research content. be able and willing to provide written informed consent and effective contact information, and be willing to cooperate with follow-up investigations. Exclusion Criteria: above the age of 40 with history of adverse pregnancy and childbirth

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
Female

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: induced termination of pregnancy|Medically, induced termination of pregnancy (I-TOP) is defined as an intervention to voluntarily terminate a pregnancy (ie, induced abortion) by either surgical or medical means so it does not result in a live birth.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| adverse pregnancy outcomes | the rate of different adverse pregnancy outcomes | 2021.6 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Complications | the rate of different complications | 2020.6 |
Safety and Efficacy of Intravenous Valproate in Pediatric Status Epilepticus and Acute Repetitive Seizures

Study Overview
=================
Brief Summary
-----------------
To evaluate the safety and efficacy of intravenous valproate in pediatric status epilepticus and acute repetitive seizures as part of seizure treatment protocol in pediatric ER

Conditions
-----------------
Status Epilepticus

Intervention / Treatment
-----------------
* Drug: Valproate


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Child with clinical presentation of status epilepticus Exclusion Criteria: All others

Ages Eligible for Study
-----------------
Minimum Age: 6 Months
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Pediatric status epilepticus<br> | Drug: Valproate<br>* Intravenous valproate application to pediatric patients suffering from status epilepticus and acute repetitive seizures<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Safety of intravenous valproate in pediatric status epilepticus |  | One week | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Efficacy of intravenous valproate in pediatric status epilepticus |  | One week |
Combined Method for Induction of Labor

Study Overview
=================
Brief Summary
-----------------
Induction of labor is performed via the vaginal misorostol 25 ug/ 6 hours and intracervical foley's cather administration and both techniques performed together.

Conditions
-----------------
Induced Labor

Intervention / Treatment
-----------------
* Drug: Misoprostol ( Prostaglandin E2)
* Device: Foley's catheter


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: females presenting for induction of labor Exclusion Criteria: previous cesarean section previous uterine scars e.g. myomectomy refusal to participate in the study

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Misoprostol<br>in this group misoprostol 25 ug will be administrated for induction of labor every 6 hours | Drug: Misoprostol ( Prostaglandin E2)<br> <br> * Other names: Cytotec;|
| Experimental: Foley's catheter<br>In this group foley's catheter 30 cc will be used for induction of labor | Device: Foley's catheter<br> <br> |
| Experimental: Combined<br>Both misoprostol 25 ug and foley's catheter will be used for induction | Drug: Misoprostol ( Prostaglandin E2)<br> <br> * Other names: Cytotec;Device: Foley's catheter<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Duration of induction of labor |  | 24 hours |
Effect of Initial Empirical PEEP Setting on the Esophageal Pressure-guided PEEP Titration in ARDS

Study Overview
=================
Brief Summary
-----------------
Esophageal manometry was used as surrogate of pleural pressure to titrate positive end-expiratory pressure (PEEP) in ARDS patients. However, Absolute values of esophageal pressure (Pes) could be affected by the PEEP setting. In moderate to severe ARDS patients, the end-expiratory Pes changed differently with PEEP adjustment. and the esophageal phenotypes could be divided into type I and type II. with Type I （ΔPes≥30%ΔPEEP）and Type II（ΔPes<30%ΔPEEP）.

Official Title
-----------------
Effect of Initial Empirical Positive End-Expiratory Pressure (PEEP) Setting on the Esophageal Pressure-guided PEEP Titration in Acute Respiratory Distress Syndrome

Conditions
-----------------
ARDS, Human, PEEP, Occult, Esophageal and Pleural Pressure

Intervention / Treatment
-----------------
* Other: PEEP adjustment


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: - aged over 18 all the moderate to severe ARDS patients invasive mechanical ventilation Exclusion Criteria: aged<18 contraindication to esophageal catheter

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Type I: ΔPes≥30%ΔPEEP<br> | Other: PEEP adjustment<br>* adjusting PEEP about 3-5cmH2O (increase or decrease)<br>|
| Type II: ΔPes<30%ΔPEEP<br> | Other: PEEP adjustment<br>* adjusting PEEP about 3-5cmH2O (increase or decrease)<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the changes of esophageal pressure during the PEEP titration |  | March 1st to May 31st, 2022 |
Comparing Maximal and Half-maximal Suction Pressure Applied During Water Exchange in Colonoscopy

Study Overview
=================
Brief Summary
-----------------
This prospective, randomize, controlled trial will compared maximal to half-maximal suction pressure applied during water exchange in patients undergoing minimally sedated colonoscopy. We test the hypothesis that maximal suction pressure is more efficient and causes shorter insertion time.

Official Title
-----------------
A Randomized, Controlled Trial Comparing Maximal and Half-maximal Suction Pressure Applied During Water Exchange in Colonoscopy

Conditions
-----------------
Minimally Sedated Patient Undergoing Colonoscopy

Intervention / Treatment
-----------------
* Procedure: half-maximal pressure
* Procedure: maximal pressure
* Device: Suction Unit


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients undergoing minimally sedated colonoscopy performed by YHH Exclusion Criteria: known history of obstructive lesions of the colon, allergy to meperidine, massive ascites, past history of partial colectomy, or refusal to provide written informed consent.

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: maximal suction pressure<br>The pressure level of the suction unit (DF 601, Hanlien, Taipei, Taiwan) will be set at the maximal (-70 cm Hg). | Procedure: maximal pressure<br>* The pressure level of the suction unit (DF 601, Hanlien, Taipei, Taiwan) will be set at the maximal (-70 cm Hg).<br>Device: Suction Unit<br> <br> * Other names: suction unit (DF 601, Hanlien, Taipei, Taiwan);|
| Active Comparator: half-maximal pressure<br>The pressure level of the suction unit will be set at the half-maximal (-35 cm Hg). | Procedure: half-maximal pressure<br>* the pressure level of the suction unit (DF 601, Hanlien, Taipei, Taiwan) will be set at the half-maximal (-35 cm Hg).<br>Device: Suction Unit<br> <br> * Other names: suction unit (DF 601, Hanlien, Taipei, Taiwan);|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| cecal intubation time |  | 30 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| infused water amount |  | 30 minutes | 
| aspirated water amount |  | 30 minutes | 
| pain score |  | 30 minutes | 
| suction marks on the mucosa |  | 30 minutes | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
cecal intubation time, water exchange, pain
Dexmedetomidine Versus Ketamine Versus Midazolam in Endoscopic Procedures

Study Overview
=================
Brief Summary
-----------------
This study aims to assess the safety and efficacy of dexmedetomidine versus ketamine versus midazolam combined with propofol in cancer patients undergoing gastrointestinal endoscopic procedures.

Detailed Description
-----------------
Comparison between using intravenous (IV) propofol combined with either IV dexmedetomidine or IV ketamine or IV midazolam; to study the effect of their combination on level of sedation and hemodynamic stability on adult patients scheduled for gastrointestinal endoscopic procedures.

Official Title
-----------------
Safety and Efficacy of Dexmedetomidine vs Ketamine vs Midazolam Combined With Propofol in Gastrointestinal Procedures for Cancer Patients

Conditions
-----------------
Sedation and Analgesia

Intervention / Treatment
-----------------
* Drug: Dexmedetomidine
* Drug: Ketamine
* Drug: Midazolam


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients scheduled for gastrointestinal endoscopic procedures ≥ Age 18 years ASA I-II Exclusion Criteria: Allergy to any of the used drugs impaired renal or liver functions hypertensive patients patients with cardiovascular cerebrovascular disease

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: dexmedetomidine<br>IV dexmedetomidine | Drug: Dexmedetomidine<br>* intravenous dexmedetomidine 1 mic/kg<br>* Other names: propofol- dexmedetomidine;|
| Experimental: ketamine<br>IV ketamine | Drug: Ketamine<br>* ketamine 1mg/kg<br>* Other names: propofol- ketamine;|
| Active Comparator: Midazolam<br>IV midazolam | Drug: Midazolam<br>* midazolam 0.05 mg/kg<br>* Other names: propofol- midazolam;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ramsy sedation score (RSS) | time to achievement of Ramsy sedation score (RSS) 3-4, Ramsy sedation scale score from 1 to 6, 1 meaning anxious and 6 meaning no response to stimulus | 3 to 6 months |