Radiomics for Prediction of Long Term Survival and Local Failure After Stereotactic Radiotherapy for Brain Metastases

Study Overview
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Brief Summary
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Published prognostic scores have limitations in prediction of long term survival after stereotactic radiotherapy for brain metastases. Moreover, no validated tools are available for prediction of local failure. The value of radiomics is evaluated in this perspective.

Detailed Description
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Sensitivity is low for prediction of long term survival of currently available prognostic scores for brain metastases. First the current clinical models will be optimized with a new prognostic model and nomogram. Radiomics is a tool to analyze tumor characteristics based on CT and MR images. These tumor characteristics may reflect tumor biology and outcome. Therefore it is investigated if radiomics improves prediction of long term survival after stereotactic radiotherapy for brain metastases. Moreover, the predictive value of radiomics for local failure is investigated.

Official Title
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Value of Radiomics for the Prediction of Long Term Survival and Local Failure After Stereotactic Radiotherapy (SRT) for Brain Metastases

Conditions
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Metastases, Neoplasm

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Cerebral metastasized patients Exclusion Criteria: -

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sensitive value of 12 months survival after stereotactic radiotherapy for brain metastases with radiomics | Sensitivity of 12 months survival after stereotactic radiotherapy for brain metastases with radiomics. Radiomics is a tool to analyze tumor characteristics based on CT and MR images. | 1 year | 
| Sensitive value of 12 months local failure after stereotactic radiotherapy for brain metastases with radiomics | Sensitivity of 12 months local failure after stereotactic radiotherapy for brain metastases with radiomics. Radiomics is a tool to analyze tumor characteristics based on CT and MR images. | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Specificity of 12 months survival and local failure after stereotactic radiotherapy for brain metastases with radiomics. | Specificity of 12 months survival and local failure after stereotactic radiotherapy for brain metastases with radiomics. | 1 year | 
| Positive predictive value of 12 months survival and local failure after stereotactic radiotherapy for brain metastases with radiomics. | Positive predictive value of 12 months survival and local failure after stereotactic radiotherapy for brain metastases with radiomics. | 1 year | 
| Negative predictive value of 12 months survival and local failure after stereotactic radiotherapy for brain metastases with radiomics. | Negative predictive value of 12 months survival and local failure after stereotactic radiotherapy for brain metastases with radiomics. | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Metastases,, Neoplasm, Cerebral