linjc16/ctgov huggingface dataset:
Sitting Balance in Lower Limb Amputees

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to compare the sitting and standing postural stability of transfemoral individuals with healthy individuals with similar demographic characteristics.

Detailed Description
-----------------
Postural stability is important for amputees to perform daily life activities and participate in social activities. The aim of this study is to compare the sitting and standing stability of transfemoral individuals with healthy individuals with similar demographic characteristics. A force platform was used to measure the postural stability of individuals. The sitting limits of stability of the participants were recorded in cm. Amputees between the ages of 18-50, using their prosthesis for at least 6 months, and healthy individuals with similar demographic characteristics were included in the study. Congenital amputees, individuals with bilateral lower extremity amputations, and individuals with central or peripheral vestibular disorders were excluded. Our study will reveal the importance of sitting stability limits in the evaluation and treatment of amputees.

Official Title
-----------------
Evaluation of Sitting Balance in Lower Limb Amputees: a Case Control Study

Conditions
-----------------
Amputation, Traumatic Amputation of Lower Extremity

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria for amputee: Unilateral transfemoral amputation Using their prosthesis for at least 6 months Exclusion Criteria: congenital amputee Bilateral lower extremity amputation Central or peripheral vestibular disorders

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1) Experimental Group: Transfemoral Amputee<br>Balance assessment in sitting | |
| 2) Control Group: Healthy Subjects<br>Balance assessment in sitting | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Limits of stability | Limits of stability test evaluates dynamic balance of participants. Computerized balance system measured limits of stability for forward, backward, right and left side movements in sitting. It calculates the maximum distance a person can lean without losing balance. The unit of measure is centimeters. The higher value is indicated the better balance. | 15 minutes | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Limits of stability, Sitting balance, Standing balance
Epiretinal Membrane and Pseudophakic Cystoid Macular Edema

Study Overview
=================
Brief Summary
-----------------
Prospective, observational cohort study evaluating the association between pre-surgical existence of an epiretinal membrane (ERM) and the development of pseudophakic cystoid macular edema (PCME) using spectral domain optical coherence tomography (OCT) measurements.

Official Title
-----------------
Association of Cystoid Macular Edema After Cataract Surgery in Patients With and Without Epiretinal Membrane

Conditions
-----------------
Macular Edema, Epiretinal Membrane

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 18 years or older Cataract surgery patients Exclusion Criteria: Pre-existing macular edema Choroidal neovascularization Uveitis Age-related macular degeneration Myopia > 6 diopters Proliferative diabetic retinopathy Diabetics retinopathy great than mild in serverity

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Study Group<br>Patients with diagnosed epiretinal membrane undergoing cataract surgery. | |
| Control Group<br>Patients without epiretinal membrane undergoing cataract surgery. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cystoid Macular Edema diagnosed by OCT |  | Within 90 days post op |
Inguinal Hernia Operation and Postoperative Pain

Study Overview
=================
Brief Summary
-----------------
Inguinal hernia is a common disease, which is treated surgically when symptomatic. Pain after open inguinal hernia surgery can affect the patient significantly and weaken their quality of life. The aim of this study is to find out if the choice of mesh affects postoperative pain and therefore causes more contacts to the health care center. Our goal is also to find out how the pain affects the patients´ quality of life.

Official Title
-----------------
Inguinal Hernia Operation and Postoperative Pain - a Prospective and Randomized Study

Conditions
-----------------
Pain, Postoperative, Inguinal Hernia, Quality of Life

Intervention / Treatment
-----------------
* Procedure: Adhesix mesh
* Procedure: Progrip mesh


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 18-80 years old male patients, with a symptomatic inguinal hernia that can be diagnosed by clinical examination. Primary and unilateral hernia. The operation performed at a day surgery unit. Exclusion Criteria: female bilateral hernia Incarcerated hernia Scrotal hernia ASA-classification >3 BMI >35 or <18 No hernia found in clinical examination Liver cirrhosis Other contraindication for inguinal hernia operation Anticoagulant therapy, that needs bridge therapy when paused

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Group1: Adhesix<br>This group gets the Adhesix mesh in a normal open hernia operation. | Procedure: Adhesix mesh<br>* Adhesix mesh<br>|
| Active Comparator: Group 2: Progrip<br>This group gets the Progrip mesh in a normal open hernia operation. | Procedure: Progrip mesh<br>* Progrip mesh<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of contacts due to postoperative pain | Number of postoperative contacts to the operating unit due to pain at 3 months after the operation | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The use of pain medication | The use of painkillers postoperatively | 1 year | 
| Pain intensity | The pain intensity at the Numeric Pain Rating Scale (NPRS), where the 11-point numeric scale ranges from '0' representing one pain extreme (e.g. no pain) to '10' representing the other pain extreme (e.g. pain as bad as you can imagine) | 1 year | 
| Number of contacts | Number of contacts to the operating unit/health care system due to pain after the operation | 1 year |
This Study is to Determine if Degenerative Spinal Pain and Disorders Cause the Levels of Substance P to Change in a Patients Saliva, Blood and/or Cerebrospinal Fluid.

Study Overview
=================
Brief Summary
-----------------
The objective of this pilot study is to determine if degenerative spinal disorders such as acute radiculopathy, myelopathy, stenosis, or disc and facet disease cause detectable alterations in Substance P levels in saliva, serum and cerebrospinal fluid. If this pilot study shows a correlation between Substance P levels and pain associated with degenerative spinal disorders, then a larger study will be initiated to determine the feasibility of using Substance P levels in the diagnosis and treatment of degenerative spinal disease.

Official Title
-----------------
Substance P Neuropeptide Levels in Saliva, Serum and Cerebrospinal Fluid in Patients With Spinal Disease: A Pilot Study

Conditions
-----------------
Spinal Disease, Spinal Radiculopathy, Myelopathy, Neurogenic Claudication

Intervention / Treatment
-----------------
* Other: treatment plan


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Undergoing spinal surgery for medically refractory spinal radiculopathy, myelopathy or neurogenic claudication based on either history, physical examination or radiologic studies demonstrating neural compression or degenerative disc disease. Undergoing surgery for medically refractory axial spinal pain. Exclusion Criteria: Previous spinal procedures or operations, radicular pain, history of fibromyalgia, chronic pain, rheumatoid arthritis, autoimmune disorders, HIV, PTSD, Major Depressive Disorder, migraine headaches or active rhinosinusitis, nicotine intake

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Healthy volunteers<br> | |
| surgery for spinal radiculopathy<br> | Other: treatment plan<br>* Data Collection Study<br>|
| surgery for axial spine pain<br> | Other: treatment plan<br>* Data Collection Study<br>|
| myelography for spinal pain<br> | Other: treatment plan<br>* Data Collection Study<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Substance P Neuropeptide Levels in Saliva And Serum in Patients with Spinal Disease: A Pilot Study | Study was closed pending re-design at some future date to improve efficacy. | 2009-2014 |
The Effect of Coleus Forskohlii Extract on the Risk Factors of Metabolic Syndrome

Study Overview
=================
Brief Summary
-----------------
Coleus forskohlii extract contains the bioactive compound, forskolin. Preliminary studies have shown that forskolin can increase fat metabolism thus reduce fat accumulation in both animals and humans. It has been suggested that forskolin may also suppress appetite thus reduce energy intake and results in weight loss. This study will evaluate the appetite suppressant properties of Coleus forskohlii extract. In addition the effect on central obesity and risk factors of metabolic syndrome will also be investigated.

Official Title
-----------------
Investigation of Appetite Suppressant Properties Associated With Coleus Forskohlii in Overweight and Obese Individuals

Conditions
-----------------
Obesity, Metabolic Syndrome

Intervention / Treatment
-----------------
* Dietary Supplement: Coleus forskohlii extract
* Other: Placebo


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Both Australian males and females, age 20-60 years, Overweight or obese (BMI >25), waist circumference of > 94 cm (male), waist circumference of >80 cm (female) Exclusion Criteria: Cigarette smoker, hypertension, all types of heart, liver and kidney disease, pregnancy, lactating, Type 1 diabetes and weight loss medication.

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Coleus forskohlii extract<br>Ingestion of 250 mg capsle (Coleus forskohlii extract) twice a day for 12 weeks | Dietary Supplement: Coleus forskohlii extract<br>* Ingestion of 250 mg Coleus forskohlii extract capsule twice a day for 12 weeks<br>|
| Placebo Comparator: Placebo<br>Ingestion of 250 mg capsule (placebo) twice a day for 12 weeks | Other: Placebo<br>* Ingestion of 250 mg placebo capsule twice a day for 12 weeks<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| changes in appetite will be assessed using visual analogue scale; blood hormone levels will also be measured using commercial kits. |  | Baseline and 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| reduction in central obesity - waist circumference will be measured on fortnight basis |  | 12 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
obesity, herbal remedies, metabolic disorders
The Influencing Factors of Vancomycin Trough Level and the Rate Achieving the Target Trough Level

Study Overview
=================
Brief Summary
-----------------
The aim of this study was to assess factors that may influence vancomycin trough level and the rate achieving the target trough level in critically ill patients.

Detailed Description
-----------------
This retrospective observational study included adult patients treated with intravenous vancomycin in intensive care unit of Zhongda Hospital from January 2015 to December 2017. Vancomycin dose was based on international consensus and adjusted according to estimated glomerular filtration rate (eGFR) calculated by the Cockcroft-Gault equation. vancomycin trough level (VTL) was retained at steady state (after the third dose). Linear regression was performed to determine the correlation between factors prior to the first vancomycin dose and VTL. Distribution of VTL and percentage of patients achieving the target trough level (15-20mg/L) was observed in different renal function.

Official Title
-----------------
The Influencing Factors of Vancomycin Trough Level and the Rate Achieving the Target Trough Level in Critically Ill Patients: A Retrospective Observational Study

Conditions
-----------------
Vancomycin

Intervention / Treatment
-----------------
* Drug: Vancomycin


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adult ICU patients (age≥18 years) treated with intravenous vancomycin were included Exclusion Criteria: Chronic renal dysfunction and acute renal injury patients treated with Renal Replacement therapy VTL was not retained at steady-state Vancomycin treatment time≤48h Vancomycin dose did not meet study definitions Palliative care

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Vancomycin|adult patients treated with intravenous vancomycin in intensive care unit|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of patients achieving the target vancomycin trough（15-20mg/L） | Vancomycin trough level was retained at steady state (after the third dose). If a patient has multiple measurements of vancomycin trough level, the first measurement is collected.Rate of patients achieving the target trough level (15-20mg/L) was observed. | 3 years |
The Munich Knee Questionnaire - Development and Validation

Study Overview
=================
Brief Summary
-----------------
the purpose of this study is to develop and validate a new PRO measurement tool for the knee joint, the so-called Munich Knee Questionnaire (MKQ), allowing for a qualitative self-assessment of the Knee Injury and Osteoarthritis Outcome Score (KOOS), the International Knee Documentation Committee (IKDC), the Lysholm Knee Score, the Western Ontario Meniscal Evaluation Tool (WOMET) and the Tegner Score.

Detailed Description
-----------------
A systematic review of the literature was performed to identify valid and commonly used instruments regarding follow-up examinations in the field of knee surgery. PubMed.gov was searched for knee-specific terms (knee, surgery, joint, lower extremity) combined with psychometric (follow-up, validity, reliability, responsiveness) and instrument-specific terms (self-reported, patient-based, measurement tool, outcome measure, questionnaire). Hence, the KOOS, IKDC, Lysholm, WOMET and Tegner Score were identified as frequent used and valid measurement tools in the evaluation of knee joint function. After analysing each single question of these questionnaires for coincidences regarding measurement of specific knee function, the identified items were condensed to one single question for each specific item. Typical functional abilities (flexion/extension) were depicted as photographs. Thus, one single questionnaire with a total of 33 questions divided in five subscales (Symptoms, Pain, Work and Activities of daily life, Sports and Recreational activities, Physical function and knee related Quality of Life), was created.

Official Title
-----------------
The Munich Knee Questionnaire (MKQ) - Development and Validation of a New Patient-reported Outcome Measurement Tool in Knee Surgery

Conditions
-----------------
Knee Injury

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: all patients presenting with knee pain Exclusion Criteria: no exclusion

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| knee pain<br>patients suffering from knee injury | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Munich Knee Questionnaire (MKQ) |  | up to 6 weeks starting from onset of symptoms | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The self-assessment of the Knee Injury and Osteoarthritis Outcome Score (KOOS) |  | up to 6 weeks starting from onset of symptoms | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Assessment
A Case-control Study of Costa Rican Adults With Myocardial Infarction

Study Overview
=================
Brief Summary
-----------------
This observational case-control trial sought to identify and characterize different exposures associated with nonfatal acute myocardial infarction in Costa Rican adults. Exposures assessed included dietary variables and adipose tissue fatty acids.

Conditions
-----------------
Myocardial Infarction, Acute

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Cases were eligible if they met the World Health Organization criteria for MI Exclusion Criteria (Cases): Died during hospitalization Were 75 years or older on the day of their first MI Were physically or mentally unable to answer the questionnaire Had a previous hospital admission related to cardiovascular disease Exclusion Criteria (Controls): Ever had an MI Were physically or mentally unable to answer the questionnaire

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cases<br>Cases consisted of Costa Rican adults who were diagnosed as survivors of a first acute myocardial infarction. | |
| Controls<br>Controls consisted of healthy individuals randomly identified from the underlying source population in Costa Rica and matched to each case by age, sex, and area of residence. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Nonfatal Acute Myocardial Infarction | Identified by independent examinations of two cardiologists at any of the six recruiting hospitals in the catchment area of the Central Valley of Costa Rica. Outcome was determined as being met if they met the World Health Organization criteria for myocardial infarction. | 1994-2004 |
Thyroid Hormone Values and Anti-thyroid Peroxidase Antibody Positivity in Recurrent Pregnancy Loss

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to compare the thyroid hormone values and anti-thyroid peroxidase (anti-TPO) levels of women with a diagnosis of recurrent pregnancy loss (RPL) and healthy pregnancies. The primary objective is to find out the relationship between recurrent pregnancy loss with thyroid hormone levels and anti-TPO positivity.

Official Title
-----------------
Relationship Between Habitual Abortion With Thyroid Hormone Values and Anti-TPO (Anti-thyroid Peroxidase Antibody) Positivity

Conditions
-----------------
Autoimmune Thyroiditis, Recurrent Miscarriage

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: women with 2 or more pregnancy loses for controls women with least one healthy baby Exclusion Criteria: any other metabolic disease women with one miscarriage

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Recurrent Pregnancy loss<br>patients with a diagnosis of recurrent miscarriage | |
| Healthy Controls<br>healthy women at same age and similar demographics | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Anti-thyroid Peroxidase Antibodies | presence of Anti-thyroid Peroxidase Antibodies in both groups | 4 years | 
| Thyroid Hormone Levels | levels of Thyroid stimulant Hormone, Thyroxin and triiodothyronine levels | 4 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Thyroid Hormones, Anti Thyroid Peroxidase Antibody, Recurrent pregnancy loss