A Study in Myeloproliferative Disorders

Study Overview
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Brief Summary
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The purpose of this study is to find out the safe dose range of the study drug in patients with myeloproliferative disorders.

Detailed Description
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The purpose of the study is to learn: How much and how often LY2784544 should be given to patients What is the safety profile of LY2784544 and any side effects that might be associated with it How LY2784544 is taken up, distributed, broken down, and passed out of your body Whether LY2784544 can help patients with myeloproliferative disorders If any markers in the blood (biomarkers) can identify patients who will respond better to the study drug. The planned duration of the study is not fixed. The length of time patients participate in the study will be determined by the investigator/study doctor. Part A of the study is to determine the dose of the study drug. Part A is divided into two sections, A1 and A2. In Part A1, patients will be given study drug without a lead-in period. In Parts A2 and B, patients will have a lead-in period of 2 or 4 weeks with a low dose of LY2784544 prior to taking a higher dose of LY2784544. Part B of the study is to confirm the safety of the dose and schedule.

Official Title
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A Phase 1 Study of LY2784544 in Patients With JAK2 V617F-Positive Myeloproliferative Disorders

Conditions
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Myeloproliferative Disorders, Thrombocythemia, Essential, Polycythemia Vera, Primary Myelofibrosis

Intervention / Treatment
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* Drug: LY2784544


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Have a diagnosis of polycythemia vera (PV), essential thrombocythemia (ET), or myelofibrosis (MF) as defined by the World Health Organization (WHO) diagnostic criteria for myeloproliferative neoplasms and meet the following additional sub-type specific criteria: A. PV: has failed or is intolerant of standard therapies or refuses to take standard medications B. ET: has failed or is intolerant of standard therapies or refuses to take standard medications C. MF (patients with MF must meet at least one of the following): i. has intermediate or high-risk MF according to the Lille scoring system; or ii. has symptomatic MF with spleen greater than 10 cm below left costal margin; or iii. has post-polycythemic MF; or iv. has post-ET MF Have a quantifiable JAK2 V617F mutation Have discontinued all previous approved therapies for myeloproliferative disorders, including any chemotherapy, immunomodulating therapy (for example, thalidomide, interferon-alpha), immunosuppressive therapy (for example, corticosteroids greater than 10 mg/day prednisone or equivalent), radiotherapy, and erythropoietin, thrombopoietin, or granulocyte colony stimulating factor for at least 14 days and recovered from the acute effects of therapy. Hydroxyurea used to control blood cell counts is permitted at study entry if the subject has been maintained on a stable dose for at least 4 weeks. Low-dose acetylsalicylic acid (aspirin) is permitted as well Exclusion Criteria: Have received treatment within 14 days of the initial dose of study drug with an experimental agent that has not received regulatory approval for any indication Are currently being treated with agents that are metabolized by CYP3A4 with a narrow therapeutic margin (for example, alfentanil, cyclosporine, diergotamine, ergotamine, fentanyl, pimozide, quinidine, sirolimus, and tacrolimus) or CYP2B6 (for example, cyclophosphamide, ifosfamide, tamoxifen, efavirenz, propofol, methadone, and bupropion) Are currently being treated with warfarin or one of its derivatives which is known to alter levels of protein C or protein S. An exception to this criterion will be allowed for patients with a prior history of Budd-Chiari Syndrome who are being treated with warfarin or one of its derivatives

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: LY2784544<br> | Drug: LY2784544<br>* LY2784544 will be supplied as a capsule. The study drug will be taken by mouth daily while the patient is on study. In this study, different patients will be treated at different doses of LY2784544 until reaching the highest dose that patients can tolerate.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Determination of a recommended Phase 2 dosing regimen |  | Time of first dose until last dose | 
| Number of participants with clinical significant effects |  | Time of first dose until last dose | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Preliminary pharmacokinetics of LY2784544 (Cmax) |  | Part A1: Day 1,2,15, and 29; Part A2: Day 7, 14, 21, 28, 29, 56, and 57; Part B: Day 1, 29, 57, and 113 | 
| Preliminary pharmacokinetics of LY2784544 (AUC) |  | Part A1: Day 1,2,15, and 29; Part A2: Day 7, 14, 21, 28, 29, 56, and 57; Part B: Day 1, 29, 57, and 113 | 
| Malignant clone burden |  | Part A1: Baseline (2 times), Weeks 13, 21 and every 6 months while patient is on study; Parts A2 and B: Baseline (2 times), Weeks 5, 8, 17, 25 and every 6 months while patient is on study |