Acute Effects of Oral Carbohydrate and Fat Loads on Systemic Microvascular Endothelial Function in Healthy Individuals.

Study Overview
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Brief Summary
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The present study was designed to evaluate vascular endothelial dysfunction resulting from the oral ingestion of high loads of sugar and fat meals in healthy individuals.

Detailed Description
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The chronic and elevated consumption of fat and carbohydrates is associated with the initiation and the progression of cardiovascular and metabolic diseases, including diabetes, obesity and metabolic syndrome. In general, chronic diseases are related to underlying modifiable cardiovascular risk factors, including high blood pressure, high plasma lipids and glucose, physical inactivity, overweight and obesity, as well as smoking habits. Vascular endothelial dysfunction is one of the earliest findings in the pathophysiology of atherosclerosis and also an important predictor of cardiovascular events. Moreover, it has already been demonstrated that acute oral ingestion of high loads of sugar and fat meals induces transient vascular endothelial dysfunction, which over time could lead to cardiovascular disease. Thus, the present study aimed at investigating the individual contributions of sugar and fat ingestion on systemic microvascular endothelial reactivity.

Official Title
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Acute Effects of Standardized Oral Carbohydrate and Fat Loads, and the Association of Carbohydrate and Fat Loads, on Systemic Microvascular Endothelial Function in Healthy Individuals.

Conditions
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Metabolic Syndrome

Intervention / Treatment
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* Other: sugar oral load
* Other: fat oral load
* Other: sugar and fat oral load


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: healthy individuals presenting body mass index between 18.5 e 24.9 kg/m2 Exclusion Criteria: dysglycemia and dyslipidemia overweight and obesity

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 30 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: sugar oral load<br>oral ingestion of a high carbohydrate meal | Other: sugar oral load<br>* The individuals will receive a sugar oral load (high sugar meal)<br>* Other names: dietary intervention;|
| Experimental: fat oral load<br>oral ingestion of a high fat meal | Other: fat oral load<br>* The individuals will a receive fat oral load (high fat meal)<br>* Other names: dietary intervention;|
| Experimental: sugar and fat oral loads<br>oral ingestion of a high carbohydrate and fat meal | Other: sugar and fat oral load<br>* The individuals will a receive sugar and fat oral load (high sugar and high fat meal)<br>* Other names: dietary intervention;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| endothelial-dependent microvascular function | alterations in skin microvascular conductance using laser-based methods | one day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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vascular endothelial function, systemic microvascular reactivity, dysglycemia, dyslipidemia