Serum Carotenoids and Risk of Gastrointestinal Tract Cancer: Meta-analysis of Ten Studies

Study Overview
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Brief Summary
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Previous studies have suggested that serum carotenoids may be associated with risk of gastrointestinal tract cancer (GIT cancer), but the results were inconsistent. Thus, the investigators conducted a meta-analysis to evaluate the associations between serum carotenoids and risk of GIT cancer.

Official Title
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Serum Carotenoids and Risk of Gastrointestinal Tract Cancer: Meta-analysis of Ten Studies

Conditions
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Gastrointestinal Tract Cancer

Intervention / Treatment
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* Other: serum carotenoids


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: The study had both case and control groups Serum carotenoids levels, relative risk (RR) or OR and corresponding 95% CI were reported Patients in case group were diagnosed with GIT cancer Exclusion Criteria: ·Animal studies
Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Jing Huang et. al, 2017<br> | Other: serum carotenoids<br>* In each study, the serum concentrations of carotenoids were detected by high performance liquid chromatography<br>|
| Max Leenders et. al,2014<br> | Other: serum carotenoids<br>* In each study, the serum concentrations of carotenoids were detected by high performance liquid chromatography<br>|
| Yusuke Okuyama et. al,2014<br> | Other: serum carotenoids<br>* In each study, the serum concentrations of carotenoids were detected by high performance liquid chromatography<br>|
| GC Kabat et. al,2012<br> | Other: serum carotenoids<br>* In each study, the serum concentrations of carotenoids were detected by high performance liquid chromatography<br>|
| Christina Persson et. al,2008<br> | Other: serum carotenoids<br>* In each study, the serum concentrations of carotenoids were detected by high performance liquid chromatography<br>|
| M Jenab et. al,2006<br> | Other: serum carotenoids<br>* In each study, the serum concentrations of carotenoids were detected by high performance liquid chromatography<br>|
| Kenji Wakai et. al,2005<br> | Other: serum carotenoids<br>* In each study, the serum concentrations of carotenoids were detected by high performance liquid chromatography<br>|
| Christian C. Abnet et. al,2003<br> | Other: serum carotenoids<br>* In each study, the serum concentrations of carotenoids were detected by high performance liquid chromatography<br>|
| N Malila et. al,2002<br> | Other: serum carotenoids<br>* In each study, the serum concentrations of carotenoids were detected by high performance liquid chromatography<br>|
| G Pappalardo et. al,1997<br> | Other: serum carotenoids<br>* In each study, the serum concentrations of carotenoids were detected by high performance liquid chromatography<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Gastrointestinal Tract Cancer Incident Measure | The gastrointestinal tract cancer incident would be recorded during the follow-up years. | Through study completion, an average of 5 years. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Gastrointestinal tract cancer, Meta-analysis, Serum carotenoids