linjc16/ctgov huggingface dataset:
A Study of Treatments for Fungal Infections of the Mouth and Throat in HIV-Infected Patients Who Have Had Success With Itraconazole But Not With Fluconazole

Study Overview
=================
Brief Summary
-----------------
To provide maintenance treatment with itraconazole solution for patients who were clinical responders in the ITR-USA-94 protocol, even if they subsequently relapsed.

Detailed Description
-----------------
Patients who responded to therapy on protocol FDA 236B receive maintenance with itraconazole oral solution for up to 6 months.

Official Title
-----------------
An Open-Label Extension Study of Maintenance Therapy in HIV-Positive Subjects With Fluconazole-Refractory Oropharyngeal Candidiasis Who Have Responded to Itraconazole Oral Solution

Conditions
-----------------
Candidiasis, Oral, HIV Infections

Intervention / Treatment
-----------------
* Drug: Itraconazole


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria Patients must have: Met criteria for clinical response on protocol FDA 236B with no residual visible lesion of oropharyngeal candidiasis upon completion of that study OR had initial response on protocol FDA 236B with subsequent relapse and retreatment with itraconazole solution or other therapies. Life expectancy of at least 3 months. Exclusion Criteria Co-existing Condition: Patients with the following symptoms or conditions are excluded: Underlying clinical condition that would preclude completion of study or place subject at significant risk. Judged unreliable with respect to physician's directives. Concurrent Medication: Excluded: Rifampin. Rifabutin. Phenobarbital. Phenytoin. Carbamazepine. Terfenadine. Astemizole. Systemic antifungals. Patients with the following prior conditions are excluded: Previously documented disseminated candidiasis. Previous clinically significant adverse event during treatment with itraconazole oral solution, unless clearly attributable to an intercurrent illness or condition. History of significant hepatic abnormalities or clinical evidence of significant hepatic disease within 2 months prior to study entry. Prior Medication: Excluded: Any investigational drug (other than itraconazole solution) within 1 month prior to study entry.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Itraconazole|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Itraconazole, Acquired Immunodeficiency Syndrome, AIDS-Related Complex, Candidiasis, Oral
Influence of Supportive Sandals on Y-Balance Performance on Healthy Young Individuals

Study Overview
=================
Brief Summary
-----------------
The Y-balance test is a lower extremity, dynamic test performed in single limb stance that measures a person's ability to reach in 3 directions. The test is typically conducted in barefoot. The purpose of this study is to assess the impact of footwear on Y-Balance test scores. The investigators hypothesize that by improving alignment and augmenting muscle mechanics, sandals with medial arch support may improve Y-Balance scores.

Official Title
-----------------
Influence of Supportive Sandals on Y-Balance Performance on Healthy Young Individuals

Conditions
-----------------
Y-balance Performance

Intervention / Treatment
-----------------
* Other: Sandal


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Men or Women between the ages of 21 to 40 years, inclusive Grossly intact and symmetrical neuromuscular status Able to ambulate without difficult or pain Able to understand the information in the informed consent form willing and able to sign informed consent form Exclusion Criteria: history of ankle sprain, Anterior cruciate ligament injury; recent hip, knee, foot or ankle pain within past 6 months Uncontrolled Heart (Hypertension; BP >= 140/90), Lung Disease (uncontrolled asthma or shortness of breath), or diabetes Nursing or pregnant Not willing or able to follow procedures specified by protocol and/or instructions of the study personnel Unable to fit into available shoe sizes

Ages Eligible for Study
-----------------
Minimum Age: 21 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Screening
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Sandal<br> | Other: Sandal<br>* Subjectes will be scored on the Y-Balance Test wearing an Orthaheel Sandal<br>* Other names: Orthaheel Sandal;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Y-Balance Test Score | Anterior, Posterior-medial and posterior-lateral maximum displacement (in cm) will be recorded as the best of three trials for each supportive limb in barefoot, supportive sandal and flip-flop | Day 1 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Arch Height Index | An instrumented measure of arch height will be taken | Day 1 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Y-Balance test
Nutritional Intake of Finger-food on Elderly People in Seniors's Resident

Study Overview
=================
Brief Summary
-----------------
The undernourishment and the prevention of its risk at the elderly person in seniors's resident represent a major issue in public health. The diagnosis of undernourishment and its risk are systematically recommended in these structures where the nutrition of these people is a problem because often inappropriate for their capacities of prehension and consequently for their nutritional needs. One of the solutions to remedy can be found in the  finger-food . The study FIFO (Finger-Food) suggests verifying the hypothesis which the finger-food would allow to increase the nutritional intake of the resident who have disorders of the prehension and\or requiring a nutritional stimulation and\or require an help to the preparation of the meal.

Official Title
-----------------
Nutritional Intake of Finger-food on Elderly People in Seniors's Resident

Conditions
-----------------
Nutritive Value

Intervention / Treatment
-----------------
* Other: Finger-Food
* Other: Without Finger-Food


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Residents institutionalized in seniors's resident for 3 months at least Residents in disability to feed single-handedly because of cognitive and/or physical disorders Having at least use of a hand Do not opposing the participation in the study or information and not opposition of the family / close to confidence / legal guardian in case of resident in incapacity to understand (senility, insanity) Exclusion Criteria: Confined to bed Specific diets (without residue, allergen, …) Enteral nutrition Absence motricity of 2 hands
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Nutrition with Finger-Food<br>Nutrition with Finger-Food | Other: Finger-Food<br>* Finger-Food at lunch and having diner<br>|
| Active Comparator: Nutrition without Finger-Food<br>Nutrition without Finger-Food | Other: Without Finger-Food<br>* Without finger-food<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quantitative measure of ingesta in grams | Quantitative measure of ingesta in grams | Monthly: From date of finger-food's implementation until the date of the end of the study (assessed up to 6 months) | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Finger-Food
Search for a Recanalization of the Sylvian Artery Electro-Physiological Biomarker

Study Overview
=================
Brief Summary
-----------------
Early recanalization is a major prognostic factor in vascular accidents ischemic brain injury (AIC). The acute phase therapies of AIC aim to recanalization by intravenous thrombolysis and/or mechanical thrombectomy. Recanalization is identified immediately during thrombectomy by per-procedural arteriography. For the thrombolysis, only a performed MRI will validate the recanalization. This proof of concept study aims to identify an Electro-Encephalographic biomarker (EEG) of the recanalization in real time, the EEG being easy to set up. This biomarker will be sought during recanalization certified by thrombectomy in order to identify the window time for which the biomarker must be sought on the EEG. During this study, the identified EEG biomarker can be used to validate the recanalization during the intravenous thrombolysis in future studies

Official Title
-----------------
Search for a Recanalization of the Sylvian Artery Electro-Physiological Biomarker

Conditions
-----------------
AIS

Intervention / Treatment
-----------------
* Procedure: Placement of the EGG


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patient over 18 years old Presenting a cerebral infarction with proximal occlusion of the sylvian artery requiring thrombectomy No objection to participation in the study Exclusion Criteria: Pregnant or breastfeeding women Patient benefiting from legal protection Absence of affiliation to a social protection scheme Recent cranial surgery not allowing the installation of a scalp EEG

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Placement of the EGG|Placement of the EGG before the beginning of the thrombectomy|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| IElectro-Encephalographic (EEG) marker of recanalization | dentification of an Electro-Encephalographic (EEG) marker of recanalization in patients with cerebral infarction with proximal occlusion of the sylvian artery and recanalized by mechanical thrombectomy | inclusion visit |
Pain, Inflammation and Opioid Craving

Study Overview
=================
Brief Summary
-----------------
The goal of this study is to investigate the association between response to pain and opioid craving in people with opioid use disorder. In this study, adults with opioid use disorder will be randomized to one of two brief education sessions followed by an assessment of response to pain. Investigators will test the association between response to pain and opioid craving.

Official Title
-----------------
Affective and Inflammatory Reactivity to Pain in Opioid Use Disorder

Conditions
-----------------
Opioid-use Disorder

Intervention / Treatment
-----------------
* Behavioral: Pain De-Catastrophizing
* Behavioral: Pain Education


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age 18 years or older; diagnosis of opioid use disorder chronic pain ability to read and provide informed consent Exclusion Criteria: major psychiatric or medical condition that would interfere with participation current opioid withdrawal currently receiving opioid analgesic medication for pain recent history of myocardial infarction or other serious cardiovascular condition current peripheral neuropathy, active vasculitis or severe peripheral vascular disease systematic inflammatory or autoimmune disorder admitted to current treatment episode on an involuntary status

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Pain De-Catastrophizing<br>Brief behavioral education on how to modify the interpretation of pain. | Behavioral: Pain De-Catastrophizing<br>* Experimenter-administered education and skill practice.<br>|
| Placebo Comparator: Pain Education<br>Brief behavioral education on pain. | Behavioral: Pain Education<br>* Experimenter-administered education.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Craving | Investigators will assess opioid craving using the Opioid Craving Scale, a participant-reported measure of opioid craving. Investigators will measure changes in Opioid Craving Scale total scores from baseline (prior to the one-time intervention) to immediately after the intervention. This is a continuous measure that will be measured twice within this single-session experimental session. The total scale score is calculated as an average of the 3 items, with a range from 0-10, with higher scores reflecting more craving. | 30 minutes |
Verification of Endotracheal Tube Placement With Ultrasonography (USG)

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to verification of Endotracheal Tube Placement with Ultrasonography (USG).

Detailed Description
-----------------
The purpose of this study is to verification of Endotracheal Tube Placement with Ultrasonography (USG). In this study, using of USG during verification will be compared with traditional method. In traditional methods, after intubation, verification of endotracheal tube placement is done via to monitoring of thorax movement, checking of tube fogging, auscultation of lung and stomach, capnography and radiography. In USG method, after intubation, verification of endotracheal tube placement is done via to using linear transducer. The probe will be placed transversely and longitudinally on the neck and in front of cricoid cartilage. So, collected all data from two method will be compared.

Official Title
-----------------
Verification of Endotracheal Tube Placement With Ultrasonography (USG) in Patients

Conditions
-----------------
Intubation

Intervention / Treatment
-----------------
* Diagnostic Test: USG


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: applied intubation patients Exclusion Criteria: -

Ages Eligible for Study
-----------------
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: USG|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Detection of Tube | Tube shall be detected with Ultrasonography (USG) | 1 year |
Examination and Treatment of Pain in Front Foot

Study Overview
=================
Brief Summary
-----------------
Tibial flat foot deformity is the most common reason for metatarsalgia. Flat foot deformity is a sign of degenerated problems such as weakness in ligament or fractures. Furthermore, metatarsalgia can be a sign of excessive load caused by sport activities or at work. The condition is very common at diabetics and patients with rheumatism. The purpose of the study is to examine the load under the front foot at health people and patients with metatarsalgia. Furthermore, the researchers aim at being able to assess the best treatment of the flat foot deformity at each patient.

Official Title
-----------------
Examination and Treatment of Pain in Front Foot

Conditions
-----------------
Pain

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Examination and treatment of pain in front foot Exclusion Criteria: Normal gait No pains

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 68 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Pain, Front foot, Flat foot, Metatarsalgia
Acute Effects of Smoking on Airway Dendritic Cells

Study Overview
=================
Brief Summary
-----------------
Airway dendritic cells control pulmonary immune responses to inhaled particles. It is the aim of the present study to investigate the acute effects of smoking on the number and surface molecule expression of human airway dendritic cells.

Official Title
-----------------
Acute Effects of Smoking on Airway Dendritic Cells

Conditions
-----------------
Tobacco Use Disorder

Intervention / Treatment
-----------------
* Behavioral: Smoking
* Behavioral: Smoking


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Active smoking (at least 10 cigarettes per day) Age > 18 years Exclusion Criteria: Any chronic diseases Any regular medication Any signs or symptoms of an acute infection

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: 1<br>Participants smoke 8 cigarettes in 4 hours. | Behavioral: Smoking<br>* Active Comparator: Participants smoke 8 cigarettes in 4 hours.<br>|
| Sham Comparator: 2<br>Participants are not allowed to smoke for 4 hours. | Behavioral: Smoking<br>* Sham Comparator: Participants are not allowed to smoke for 4 hours.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Total number of dendritic cells in bronchoalveolar lavage fluid |  | June - September 2008 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Surface molecule expression on dendritic cells in bronchoalveolar lavage fluid |  | June - September 2008 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Cigarette Smoking, Airway dendritic cells
HPV and Male Homosexuality in General Practice?

Study Overview
=================
Brief Summary
-----------------
The main objective of this study is to find out whether young MSM (men who have sex with men) believe it is important for their GP to be informed of their sexual orientation, in order to improve their clinical, especially with HPV vaccination. The secondary objective is to analyze the state of knowledge about the HPV vaccine and the value of HPV vaccine in this target population.

Official Title
-----------------
HPV Vaccination (Human Papilloma Virus), or How to Address Male Homosexuality in General Practice in Alsace?

Conditions
-----------------
Papilloma Viral Infection

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: Age: 18-26 years Consultation at the HUS Cegidd as part of an STI screening Subject who expressed no opposition to participating in the study Exclusion criteria: Refusal of the patient to participate in the study Subject who had already benefited from HPV vaccination (at least one dose) Inability to give informed consent Subject under safeguarde of justice Subject under guardianship or under curatorship

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 26 Years

Sexes Eligible for Study
-----------------
Male

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Retrospective descriptive study of vaccination against HPV (Human Papilloma Virus) in Alsace? |  | Files analysed retrospectively from April 27, 2021 to January 27, 2020 will be examined] | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Papilloma Viral Infection, HPV vaccine, HPV