Vibration Training for Preventing Falls in Healthy Population and Multiple Sclerosis

Study Overview
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Brief Summary
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This study is to investigate the effects of controlled whole-body vibration training on reducing the likelihood of falls among healthy population and people with multiple sclerosis. (NOTE: research not covered by sponsored funding)

Detailed Description
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For each population, the participants will be randomized into two groups.

Official Title
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Effects of Controlled Whole-body Vibration Training on Preventing Falls Among Healthy Population and Ambulatory People With Multiple Sclerosis

Conditions
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Falls Prevention

Intervention / Treatment
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* Other: Controlled whole-body vibration training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: For healthy population: Aged between 18 and 75 No known history of musculoskeletal, neurological, cardiovascular, or pulmonary impairment For people with multiple sclerosis Self-reported multiple sclerosis and confirmed by the physician No significant relapse within the past 8 weeks To be able to walk independently a length of 25 feet Score on Patient Determined Disease Step < 7 Exclusion Criteria: Subjects use any sedative of any type. The heel bone density is less than -2.0

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Vibration training group<br>The vibration group will receive 8-week controlled whole-body vibration training as the intervention on the Galileo Med L device | Other: Controlled whole-body vibration training<br>* The intervention is an 8-week program<br>* Other names: Vibration therapy; vibration training;|
| Placebo Comparator: Placebo training group<br>The placebo group will receive 8-week placebo training on the Galileo Med L device | Other: Controlled whole-body vibration training<br>* The intervention is an 8-week program<br>* Other names: Vibration therapy; vibration training;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Real life falls | Real life falls are monitored for 12 months. | Up to 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Berg Balance Scale test | This test is used to assess the body balance skill in healthy elderly. | Up to 12 months | 
| Slip-related falls on treadmill | Participants will be exposed to unexpected slips during walking on a treadmill. | Up to 12 months | 
| Functional mobility | Functional mobility is measured by using the Timed-Up-and-Go test. | Up to 12 months | 
| Sensation | Sensation is measured by nylon monofilaments kit. | Up to 12 months | 
| Muscle strength | Lower-limb joints' muscle strengths are evaluated by an isokinetic dynamometer. | Up to 12 months | 
| Range of motion | The range of motion of the lower limb joints are assessed by a goniometer. | Up to 12 months | 
| Bone density | The bone density of the heel bone is assessed by a bone ultrasonometer. | Up to 12 months | 
| Multiple Sclerosis Functional Composite score | The Multiple Sclerosis Functional Composite score, which indicates the disability level in people with multiple sclerosis, is measured | Up to 12 months | 
| Equiscale balance test | This balance test is applied to individuals with multiple sclerosis to evaluate their body balance skill. | Up to 12 months | 
| Symbol Digit Modalities test | This test measures participants' attention and information processing speed and efficiency. | Up to 12 months | 
| Selective Reminding test | This instrument assesses participants' verbal learning and memory capacity. | Up to 12 months | 
| Behavior Rating Inventory of Executive Function | This test is used to gauge one's everyday behaviors associated with specific domains of the executive functions. | Up to 12 months |