Innovation Labs to Enhance Collaboration

Study Overview
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Brief Summary
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We will conduct and evaluate the impact of two week-long Innovation Labs on collaboration attitudes and behavior among early career scholars. Applicants to each Innovation Lab will be screened and then randomized to either the Innovation Lab group or a control group.

Detailed Description
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Building on the science of team science and preliminary work at the Buffalo and Vanderbilt CTSAs, we propose to work with our industry partner Knowinnovation to implement, assess, and disseminate an innovative and promising method for stimulating and nurturing new transdisciplinary research teams across the CTSA Program consortium: Innovation Labs. We will focus on early career investigators, have well-developed expertise, and will benefit from developing transdisciplinary collaborations. This work will further advance the field by taking a strong translational science approach to identify and test best practices. To accomplish this, we will critically evaluate the impact of Innovation Labs in two preliminary randomized controlled trials (RCTs). In collaboration with NCATs and broad input from the CTSA network, we will develop a clinical and translational research grand challenge focus for each Innovation Lab. A diverse applicant pool of early career investigators invited from every CTSA hub in the consortium will be reviewed, and top applicants will be randomized to a 5-day residential Innovation Lab or treatment as usual control group (n=25/group/RCT). Measures of process and outcome will be collected from the application phase through 12-month follow-up and aggregated across the two RCTs. Given the preliminary nature of the work and an emerging consensus regarding the science of team science, primary outcomes will be measures of the depth and breadth of participants collaborative networks and attitudes towards collaboration, which we predict will be enhanced in the Innovation Lab group compared to the treatment as usual control group. We will also gather initial data on the degree to which Innovation Labs result in increased transdisciplinary collaborative output, including grant proposals, publications, and presentations. The significance of this work is clear: We aim to advance clinical and translational science by critically evaluating a potential best practice method for catalyzing collaborations and enhancing innovative translational research, a core goal of the CTSA Program. Our initial RCTs target an important segment of the workforce and begin the process of dissemination across the CTSA network, setting the stage for much broader implementation and impact.

Official Title
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Controlled Evaluation of Innovation Labs for Enhancing Collaboration Among Early Career Scholars in the CTSA Network

Conditions
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Collaboration Attitudes and Behavior

Intervention / Treatment
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* Behavioral: Innovation Lab


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Completion of application and baseline assessment. For randomization: Faculty at a NIH CTSA hub institution or regional partner. Early stage investigators (NIH-defined as within 10 years of completing his/her terminal research degree or is within 10 years of completing medical residency (or the equivalent)) who are emerging as independent scholars. Applications were reviewed for the above criteria and ranked by committee according to goodness of fit with the topic of the Innovation Lab, the quality and quantity of academic productivity and collaboration, and contribution to diversity of perspectives among Lab participants (e.g., biomedical and social/psychological, basic and applied). Top-ranked applicants were retained for randomization to the Innovation Lab group or control group. All applicants (including 94 randomized ppts and 13 ppts who were not randomized) were encouraged to remain in the study and complete the follow-up assessments.
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Innovation Lab Group<br>Randomized to attend the Innovation Lab | Behavioral: Innovation Lab<br>* An Innovation Lab is a facilitated 5-day residential event designed to create novel, transdisciplinary and potentially transformative research ideas and proposals to address a specific grand challenge. Participants, along with a director, organizers, subject matter guides, and KI facilitators communally explore the problem space, generate a broad range of ideas, and form transdisciplinary teams to pursue research projects.<br>|
| No Intervention: Control Group<br>Randomized to NOT attend the Innovation Lab | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from Baseline MATRICx Benefits Scale | Self-report: Motivation Assessment for Team Readiness, Integration, and Collaboration (MATRICx; Mallinson, Lotrecchiano, et al., 2016) - Motivator scale | through study completion, an average of 15 months | 
| Change from Baseline MATRICx Threats Scale | Self-report: Motivation Assessment for Team Readiness, Integration, and Collaboration (MATRICx; Mallinson, Lotrecchiano, et al., 2016) - Threats scale | through study completion, an average of 15 months | 
| Change from Baseline Transdisciplinary Orientation Scale | Self-report: 12-item Transdisciplinary Orientation scale (TDO; Misra, Stokols, & Cheng, 2015) | through study completion, an average of 15 months | 
| Change from Baseline Collaboration Network Size | Objective size of network of collaborators from published articles on PubMed | through study completion, an average of 15 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from Baseline Grants Submitted | Self-Reported Number of New Grants Submitted | through study completion, an average of 15 months | 
| ILab met goal - new collab | The Lab met the goal of forming new transdisciplinary collaborations (ILab group only) | 3 months | 
| ILab met goal - novel proposals | The Lab met the goal of developing novel grant proposals on long-lasting lifestyle interventions (ILab group only) | 3 months | 
| ILab - recommend | I would recommend an Innovation Lab to a colleague (ILab group only) | 3 months | 
| ILab - positive impact | My experience in the Innovation Lab will have a positive impact on my work at my home institution (ILab group only) | 3 months |