Anterior Temporal Epilepsy Neuropsychological Assessment of Faces

Study Overview
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Brief Summary
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The purpose is to evaluate neuropsychological effects of anterior temporal epilepsy in face perception by comparison of performances of epileptic patients and control individuals, sex-, age- and socio-educational level-matched. Secondary purposes are to prospectively evaluate neuropsychological impact of anterior temporal lobectomy performed for surgical treatment of anterior temporal epilepsy on face perception (exploratory study).

Official Title
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Evaluation of Neuropsychological Effects of Drug-resistant Anterior Temporal Epilepsy and Anterior Temporal Lobectomy in Face Perception

Conditions
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Anterior Temporal Epilepsy, Anterior Temporal Lobectomy, Face Perception

Intervention / Treatment
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* Other: Mooney test
* Other: Benton Face Recognition test
* Other: Face inversion effect test
* Other: Face composite effect test
* Other: Cambridge Face Memory Test
* Other: Matching different view test
* Other: Memorizing and recognition of new faces test
* Other: Memorizing and recognition of new objects test
* Other: Recognition of celebrities and access to semantic information test
* Procedure: Lobectomy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ALL: Informed consent Affiliation to social security Preliminary medical examination PATIENTS WITH EPILEPSY: Symptomatic drug-resistant anterior temporal epilepsy (confirmed with video-electroencephalography and magnetic resonance imaging and if necessary intracerebral SEEG exploration) Patient needing anterior temporal lobectomy and undergoing pre-surgery conventional intercritical assessment for surgery decision Nonverbal IQ ≥ 70 (WAIS-IV) At least 6 successful VOSP tests (perception test) Exclusion Criteria: ALL: persons under legal protection or incapable to consent Persons deprived of liberty by juridical or administrative decision PATIENTS WITH EPILEPSY: - Sever visual disorders of neurological or ophthalmological origin CONTROL INDIVIDUALS: Psychiatric or neurological disorders Important ophthalmological disorders

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Epilepsy<br>Patients do face specific tests during conventional pre-lobectomy intercritical assessment hospitalization (inclusion, day 0) and after 6 and 18 months from anterior temporal lobectomy | Other: Mooney test<br> <br> Other: Benton Face Recognition test<br> <br> Other: Face inversion effect test<br> <br> Other: Face composite effect test<br> <br> Other: Cambridge Face Memory Test<br> <br> Other: Matching different view test<br> <br> Other: Memorizing and recognition of new faces test<br> <br> Other: Memorizing and recognition of new objects test<br> <br> Other: Recognition of celebrities and access to semantic information test<br> <br> Procedure: Lobectomy<br>* In patients with anterior temporal epilepsy, at 6 to 12 months after inclusion, depending on surgery decision taken after pre-surgery conventional intercritical assessment<br>|
| Other: Control<br>Control individuals do face specific tests during inclusion visit (day 0) and after X months (X = time from day 0 and lobectomy of matched patient + 6 months) | Other: Mooney test<br> <br> Other: Benton Face Recognition test<br> <br> Other: Face inversion effect test<br> <br> Other: Face composite effect test<br> <br> Other: Cambridge Face Memory Test<br> <br> Other: Matching different view test<br> <br> Other: Memorizing and recognition of new faces test<br> <br> Other: Memorizing and recognition of new objects test<br> <br> Other: Recognition of celebrities and access to semantic information test<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Scores obtained with Benton test by patients with anterior temporal epilepsy and matched control individuals |  | day 0 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of scores obtained with Benton test by epilepsy patients before and after lobectomy and control individuals (only patients having undergone anterior temporal lobectomy and matched control individuals) |  | day 0 and after 12 to 18 months | 
| Change of scores obtained with Benton test by epilepsy patients before and after lobectomy and control individuals (only patients having undergone anterior temporal lobectomy and matched control individuals) |  | day 0 and after 24 to 30 months |