Soil-transmitted Helminth Reinfection Rates After Single and Repeated School Hygiene Education

Study Overview
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Brief Summary
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Soil-transmitted helminth (STH) infections caused by Ascaris lumbricoides, Trichuris trichiura, or hookworm, affect approximately 1.5 millions individuals primarily in tropical and subtropical regions. STHs infections have been associated with delay in growth and development in children. The prevalence in Indonesia varied from 45% to 65%, but in poor sanitation areas the prevalence can increased to 80%. World Health Organization currently recommends mass treatment with benzimidazoles and health hygiene education to control the disease. In this study we evaluated the effectiveness of single and four-monthly health hygiene education to STH reinfection rates among school-aged children in Mandailing Natal district, North Sumatera province, Indonesia.

Detailed Description
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In this study we evaluate the prevalence of STH among school-aged children using Kato Katz examination prior to enrolment to the study. Two elementary schools in Mandailing Natal district, North Sumatera province, Indonesia have been selected and received either a single or repeated health hygiene education. Preliminary knowledge was also assessed using a questionnaire. Infected children received treatment of albendazole 400 mg for 3 days. Evaluation on reinfection status and STH knowledge is done at 4 month, 8 month and 12 months.

Official Title
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Re-infection Rates of Soil-transmitted Helminth Infections Among School-aged Children Following a Single or a 4-monthly Health Hygiene Education: an Open Label Clinical Trial

Conditions
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Helminthiasis, Ascaris Infection, Trichuris Infection, Hookworm Infections, Children, Only

Intervention / Treatment
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* Behavioral: Health hygiene education


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Children who are negative for STHs infection on Kato Katz examination following 3 days treatment of albendazole Exclusion Criteria: Parents who refused to participate in the study Severe malnutrition Co-infected with other helminth infections

Ages Eligible for Study
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Minimum Age: 6 Years
Maximum Age: 15 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Single education<br>Single health hygiene education | Behavioral: Health hygiene education<br>* A cartoon video explaining the etiology, risk factors, clinical symptoms, treatment and prevention of helminthiasis were given to the school-aged children<br>|
| Experimental: Repeated education<br>Four-monthly health hygiene education | Behavioral: Health hygiene education<br>* A cartoon video explaining the etiology, risk factors, clinical symptoms, treatment and prevention of helminthiasis were given to the school-aged children<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The effectiveness of repeated health hygiene education on the reinfection rates of STHs among school-aged children | STH prevalence at 12 months | 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prevalence of STHs among school-aged children prior to intervention | Ascaris lumbricoides, Trichuris trichiura, hookworm infections at month 0 | STH prevalence at month 0 | 
| Knowledge of STHs prevention measures among school-aged children before and after intervention | A questionnaire used to evaluate the knowledge about STHs prevention | 12 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Soil-transmitted helminth, School-aged children, Health hygiene, Education