Effects of Supplementation With Ginseng and BCAA Improved Central Fatigue and Enhanced Attention During Exercise

Study Overview
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Brief Summary
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The main purpose of the present study is to determine the effects of acute and short-term (14 days) ginseng combined with branch chained amino acids supplementation on endurance exercise performance and the ability of anti-fatigue. In addition, this study also measured the performance of continuous attention during recovery period to examine the effect of supplementation on central fatigue.

Detailed Description
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Muscle fatigue was a common problem after exercise. When fatigue occured, body functions were affected and changed. Changbai Mountain ginseng had higher anti-fatigue substances than general commercial ginseng. And recent studies had showed that the supplementation of branched chain amino acids (BCAA), including leucine, isoleucine and valine, can increase attention and reduce fatigue. However, its effect on Changbai Mountain ginseng combined with BCAA was still unclear. Subjects were allocated to Gojinsen® drinks and placebo group (1:1 ratio) for 14 days, and then examined by maximal oxygen consumption, time to exhaustion, rating of perceived exertion (RPE), oxygen saturation (SPO2) , blood lactate concentration, and continuous attention performance test (CPT II). The Gojinsen® group significant increased maximal oxygen consumption, time to exhaustion, and attention compared to placebo group. Moreover, the Gojinsen® group significant decreased lactate concentration and fatigue compared to placebo group. By this study, Gojinsen® drinks did not showed absolute anti-fatigue effect but provided the objective evidence of fatigue-related measurement and the therapeutic potential for people suffering from exercise fatigue.

Official Title
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The Anti-fatigue Effect of Gojinsen® Drink

Conditions
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Exercise Addiction

Intervention / Treatment
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* Dietary Supplement: Placebo
* Dietary Supplement: Gojinsen® drinks


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: healthy male and female adults aged 20-25 years old . without heart, liver, kidney, endocrine or other major organic diseases). had at least 3 months experience in performing exercise Exclusion Criteria: 1. BMI of the study subjects must be less than 25.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 25 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Placebo<br>consume 1 sachet per day for 14 day | Dietary Supplement: Placebo<br>* consume 1 sachet per day for 14 day<br>|
| Experimental: Gojinsen® drinks<br>consume 1 sachet per day for 14 day | Dietary Supplement: Gojinsen® drinks<br>* consume 1 sachet per day for 14 day<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Endurance exercise performance testing | the subjects arrived to the laboratory and wore the oxygen uptake mask of energy metabolism analyzer (Sensor Medics, Vmax29, USA) to measure the subjects' oxygen uptake | Execution on the 14th day | 
| rating of perceived exertion | The Rated Perceived Exertion was measured during the treadmill exercise by Bruce Protocol, a gradual increase in the speed and the slope of the treadmill every 3 minutes. | Execution on the 14th day | 
| blood lactate | fingertip capillary blood was placed in automated blood lactate analyzer | Execution on the 14th day | 
| Continuous attention performance test | 10 minutes after maximal exercise test, the subjects performed attention tests that used Canon continuous attention software | Execution on the 14th day |