Long-term Results of Tonsillectomy in the Treatment of Obstructive Sleep Apnea in Adults

Study Overview
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Brief Summary
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Long-term results of tonsillectomy in the treatment of obstructive sleep apnea in adults

Detailed Description
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The investigators are studying long-term efficiency of tonsillectomy in adults with obstructive sleep apnea caused by tonsillar hypertrophy. These patients have undergone tonsillectomy in 2004-2018 and now 3-17 years later investigators will perform new polysomnographies and compare these results with preoperative values. Especially the reduction in apnea-hypopnea index (AHI) will be evaluated. The quality of life and possible symptoms will be measured with questionnaires.

Official Title
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Long-term Results of Tonsillectomy in the Treatment of Obstructive Sleep Apnea in Adults

Conditions
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Obstructive Sleep Apnea, Tonsillar Hypertrophy, Sleep Apnea Syndromes

Intervention / Treatment
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* Device: Polysomnography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age at least 16 during tonsillectomy preoperative obstructive sleep apnea and AHI (apnea-hypopnea index) > 14 tonsillectomy has been done because of the symptoms caused by tonsillar hypertrophy (ICD-10 diagnostic codes G47.3, R06.5 or J35.1) in addition to tonsillectomy, patients may have undergone shortening of uvula and/or radio frequency ablation of soft palate Exclusion Criteria: AHI < 14 in addition to tonsillectomy patient has undergone uvulectomy, uvulopalatoplasty, uvulopalatopharyngoplasty or mandibular advancement other, evaluated by investigator

Ages Eligible for Study
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Minimum Age: 16 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Polysomnography for all participants of the study<br>Polysomnography device is used to measure certain variables overnight when a participant is sleeping | Device: Polysomnography<br>* Polysomnography is performed one time overnight<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Apnea-hypopnea index | Post-operative apnea-hypopnea index (AHI) reduction by 50% compared to preoperative values in polysomnography. | 3-17 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quality of life measured by Glasgow Benefit Inventory (GBI) | General quality of life questionnaire. 18 questions, score 1-5 in each question, higher is better. | 3-17 years | 
| Quality of life measured by Epworth sleepiness scale (ESS) | Questions regarding sleepiness. Score 0-24, lower is better. | 3-17 years | 
| Apnea-index (AI) | Post-operative apnea index reduction compared to preoperative values in polysomnography. | 3-17 years | 
| Snoring time | Post-operative reduction of snoring time compared to preoperative values in polysomnography | 3-17 years | 
| Oxygen Desaturation Index (ODI) | Post-operative reduction of oxygen desaturation index compared to preoperative values in polysomnography | 3-17 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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tonsillectomy, obstructive sleep apnea, tonsil surgery