TDCS Effects on Motor Learning and Motor Control in Healthy Subjetcs

Study Overview
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Brief Summary
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Clinical Trial with two groups, transcranial direct current stimulation aplication and sham; triple blinded. The protocol is applied 5 consecutive days during the training of a manual dexterity task. Manual dexterity and somatosensory variables are measured pre intervention, post one day of intervention, post 5 days of intervention, and 5 days after finish the intervention.

Detailed Description
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Clinical Trial with two groups, transcranial direct current stimulation aplication (1 mA ) and sham (ramp up and down of 30 seconds in total) . Bouth interventions will last 20 minutes; at the same time of the aplication bouth are going to train the manual dexterity with Purdue Pegboard Test. This protocol is applied 5 consecutive days, also it have a follow up of 5 days more. It is triple blinded. Manual dexterity and somatosensory variables are measured pre intervention, post one day of intervention, post 5 days of intervention, and 5 days after finish the intervention.

Official Title
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Transcranial Direct Current Stimulation Effects on Motor Learning and Motor Control in Healthy Subjetcs

Conditions
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Healthy

Intervention / Treatment
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* Device: transcranial direct current stimularion


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: healthy volunteers Exclusion Criteria: metal or skin lesions on the head brain stimulation in the last 6 months family history of epilepsy or seizures pacemaker or any cardiac involvement inability to understand or execute the task taking drugs that may influence cognition pregnancy

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: transcranial direct current stimulation<br>20 minutes of transcranial direct current stimulation 1 mA on bi-hemispheric colocation with cathode on the left M1 and anode on the right M1 | Device: transcranial direct current stimularion<br>* aplication of direct current stimulation on the scalp wiht sponge electrodes<br>|
| Sham Comparator: sham transcrial direct current stimulation<br>20 minutes positioning the electrodes on the scalp. Whith an initial increasing of the current intensity by 10 seconds, until 1mA and a ramp down from 20 seconds to reach zero. | Device: transcranial direct current stimularion<br>* aplication of direct current stimulation on the scalp wiht sponge electrodes<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in trained manual dexterity of the dominant hand | One hand manual dexterity is measured with Perdue Pegboard test | pre intervention, post one day of intervention, post 5 days of intervention, 5 days after finish the intervention | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in trained manual dexterity of bouth hands | Two hands dexterity is measured with Perdue Pegboard test | pre intervention, post one day of intervention, post 5 days of intervention, 5 days after finish the intervention | 
| Changes in maximal isometric hand grip force | Hand grip force is measured with Jamar dinamometer | pre intervention, post one day of intervention, post 5 days of intervention, 5 days after finish the intervention | 
| Sleep Quality | Pittsburgh Sleep Quality Index | 5 days after finish the intervention | 
| Physical activity | Long form of the International Physical Activity Questionnaire | 5 days after finish the intervention | 
| Changes in nontrained manual dexterity of the dominant hand | One hand dexterity is mesured with Minesota Test | pre intervention, post one day of intervention, post 5 days of intervention, 5 days after finish the intervention | 
| Changes in nontrained manual dexterity of bouth hands | Two hands dexterity is mesured with Minesota Test | pre intervention, post one day of intervention, post 5 days of intervention, 5 days after finish the intervention | 
| Changes in pressure detection treshold | The pressure detection treshold is measured with an algometer | pre intervention, post one day of intervention, post 5 days of intervention, 5 days after finish the intervention | 
| Changes in pain detection treshold | The pain detection treshold is measured with an algometer | pre intervention, post one day of intervention, post 5 days of intervention, 5 days after finish the intervention | 
| Changes in two points discrimination | Two points discrimination is measured with an esthesiometer | pre intervention, post one day of intervention, post 5 days of intervention, 5 days after finish the intervention | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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transcranial direct current stimulation, motor learning