Propofol/Dexmedetomidine Versus Desflurane Effects on Post Hepatectomy Hepatocellular Injury

Study Overview
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Brief Summary
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This study will compare the effects of propofol/dexmedetomidine versus desflurane for maintenance of general anesthesia on hepatocellular injury in patients undergoing partial hepatectomy.

Detailed Description
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Postoperative impairment of liver function is common after hepatectomy. It may be caused by surgical trauma, loss of hepatic mass, stress response, hepatic oxygen deprivation, infection and drug toxicity. Anesthetic agents used in general anesthesia for liver surgery have a big effect on hepatic blood flow, oxygen delivery and liver function This study will compare the effects of propofol/dexmedetomidine versus desflurane for maintenance of general anesthesia on hepatocellular injury in patients undergoing partial hepatectomy.

Official Title
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Propofol/Dexmedetomidine Versus Desflurane Effects on Post Hepatectomy Hepatocellular Injury

Conditions
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Hepatectomy

Intervention / Treatment
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* Drug: Propofol, dexmedetomidine
* Drug: Desflurane


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients American Society of Anesthesiologists physical status (ASA) I to II. Patients Child Pugh classification A to B. Both sexes. Aged between 18 years and 70 years Scheduled for more than 1 segment hepatectomy. Exclusion Criteria: Patients with Child Pugh classification C. Patients younger than18 years old or older than 70 years old Patients performed additional ablation therapies (cryosurgery or radiofrequency ablation). Prior liver resection for donation. Scheduled resection not requiring inflow occlusion (Pringle's maneuver). Hypersensitivity to any of the used drugs.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: propofol and dexmedetomidine<br>Patients will receive maintenance of general anesthesia by TIVA using combination of propofol and dexmedetomidine | Drug: Propofol, dexmedetomidine<br>* Patients will receive maintenance of general anesthesia by TIVA using combination of propofol and dexmedetomidine.<br>* Other names: TIVA;|
| Experimental: desflurane<br>Patients will receive maintenance of general anesthesia by desflurane. | Drug: Desflurane<br>* Patients will receive maintenance of general anesthesia by desflurane.<br>* Other names: inhalational anesthesia;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| aspartate aminotransferase (AST) | aspartate aminotransferase (AST) | 1 week | 
| alanine aminotransferase (ALT) | alanine aminotransferase (ALT) | 1 week | 
| bilirubin | bilirubin | 1 week | 
| albumin | albumin | 1 week | 
| prothrombin time | prothrombin time | 1 week | 
| INR | INR | 1 week |