Effect of Topical Tetracycline and Dexamethasone on Periodontal and Pulpal Regeneration of Replanted Avulsed Teeth

Study Overview
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Brief Summary
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To evaluate the effect of topical tetracycline and dexamethasone on periodontal and pulpal regeneration of avulsed permanent teeth after an observation period between 9-16 years.

Detailed Description
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Two different medications were applied prior to replantation. A) Topical tetracycline, B) topical dexamethasone. Teeth were splinted using a non-rigid titanium trauma splint for 7-14 days. Endodontic treatment was performed within 1-7 days, except for teeth with an open apex and a short extraoral dry time. All patients received systemic tetracycline for 10 days after accident and were subsequently re-examined. Follow-up examinations included periodontal examination, percussion, Periotest measurements, pulp sensitivity using CO2 snow, periapical radiograph and intraoral photographs. Additionally a OHIP-14 questionnaire was carried out to determine the oral health-related quality of life.

Official Title
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Effect of Topical Tetracycline and Dexamethasone on Periodontal and Pulpal Regeneration of Replanted Avulsed Permanent Teeth: A Long-term Follow-up After 9-16 Years

Conditions
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Dental Trauma, Avulsion, Periodontal Regeneration, Pulpal Regeneration, Topical Dexamethasone, Topical Tetracycline

Intervention / Treatment
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* Procedure: Tetracycline
* Procedure: Dexamethasone


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Avulsion of a permanent tooth Written informed consent Exclusion Criteria: Extended dry period of more than 60 minutes

Ages Eligible for Study
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Minimum Age: 6 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Tetracycline<br>Teeth were soaked in topical tetracycline 5% for 5 minutes before replantation | Procedure: Tetracycline<br>* Teeth were soaked in topical tetracycline 5% for 5 minutes before replantation<br>|
| Dexamethasone<br>Teeth were soaked in dexamethasone (60μ ml-1) for 20 minutes before replantation | Procedure: Dexamethasone<br>* Teeth were soaked in topical dexamethasone (60μ ml-1) for 20 minutes before replantation<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of teeth with periodontal regeneration | Periodontal regeneration was assessed with periodontal examination, percussion, Periotest measurements and periapical radiograph. | After a mean observation period of 12.9±2.4 years (one visit only) | 
| Number of teeth with pulpal regeneration | Pulpal regeneration was assessed with periodontal examination, percussion, Periotest measurements, pulp sensitivity using CO2 snow and periapical radiograph. | After a mean observation period of 12.9±2.4 years (one visit only) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of teeth that survived | Assessed by visual inspection | After a mean observation period of 12.9±2.4 years (one visit only) | 
| Number of teeth with open versus closed apex at accident | Assessed by x-ray | At baseline | 
| Patients satisfaction | Measured by OHIP-14 score | After a mean observation period of 12.9±2.4 years (one visit only) |