The Predictive Effect of the Inflammatory Response on the Evacuation of Mechanical Ventilation and the Mechanism

Study Overview
=================
Brief Summary
-----------------
Infection and trauma take a important role in the acute respiratory failure.There are different causes and degrees of inflammatory reaction in the critically ill patient. The inflammatory reaction should also affect patients on mechanical ventilation dependence with body physiological response and disease prognosis in patients. Therefore, the investigators hypothesize that inflammation may have an important role in the prediction of weaning from mechanical ventilation.

Detailed Description
-----------------
In the process of mechanical ventilation, the patients were divided into two groups according to the failure of spontaneous breathing test and spontaneous breathing test.In the index of predicting mechanical ventilation, the investigators will take the index of inflammatory response, the function index of diaphragm and the amount of exhaled CO2 into account to reduce the failure rate of mechanical ventilation.

Official Title
-----------------
The Predictive Effect of the Inflammatory Response on the Evacuation of Mechanical Ventilation and the Mechanism

Conditions
-----------------
Systemic Inflammatory Response Syndrome, Ventilator Weaning

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: oral, nasal tracheal intubation and mechanical ventilation in patients with respiratory failure mechanical ventilation time over than 48 hours Glasgow score greater more than or equal to 13 points Exclusion Criteria: Aged less than 14 years or more than 80 years old patients with neuromuscular disease pure heart failure pulmonary edema patients patients with tracheotomy

Ages Eligible for Study
-----------------
Minimum Age: 14 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Success with SBT<br>The patient have a success in SBT. | |
| Success with mechanical ventilation<br>Weaning from mechanical ventilation is successful | |
| failure with SBT<br>The patient have a failure in SBT. | |
| failure with mechanical ventilation<br>Weaning from mechanical ventilation is failed | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The relationship between mechanical ventilation of ventilator and inflammatory response | Through the study of mechanical ventilation weaning success and failure of patients with respiratory physiological indicators, blood, urine related inflammatory indicators, analysis of the relationship between inflammatory response and mechanical ventilation weaning.The test indicators include C- reactive protein, tumor necrosis factor and some interleukin for related. | January 2014 to December 2016 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The relationship between diaphragm movement function and weaning from mechanical ventilation | To study the relationship between the inflammatory response and the contractile function of diaphragm, which is helpful to judge the effect of inflammatory factors on the evacuation of mechanical ventilation. | January 2016 to December 2017 | 
| the output of CO2 |  | January 2016 to December 2017 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Inflammatory Factor, Mechanical Ventilation