Coronary Artery Plaque Burden in Stable Angina and Non-obstructive Coronary Artery Disease

Study Overview
=================
Brief Summary
-----------------
Non-obstructive coronary artery disease (CAD), particularly common in women, has been associated with impaired quality of life and risk of recurrent hospitalizations. Several studies have also demonstrated increased risk of incident acute coronary events and mortality. The main objective of the project is to assess the association between coronary artery plaque features by coronary CT angiography and long term prognosis in a large unselected population undergoing CT coronary angiography due to stable angina and suspected myocardial ischemia from the Norwegian Registry for Invasive Cardiology (NORIC) diagnosed with non-obstructive CAD by coronary CT angiography.

Detailed Description
-----------------
Patients with stable angina and non-obstructive coronary artery disease by CT coronary angiography will be selected from the Norwegian Registry of Invasive Cardiology (NORIC). This is a national quality control registry run and controlled by the Norwegian Institute of Public Health (www.fhi.no). All CT coronary angiograms will be reanalyzed using advanced post-processing analysis software to assess coronary artery plaque burden, distribution and composition. Through linking with the Norwegian Cardiovascular Disease Registry and the Cause of Death Registry (www.fhi.no) we will be able to assess the association between long-term prognosis (5 years) and coronary artery plaque features.

Official Title
-----------------
Covariates of Coronary Artery Plaque Burden and Composition by CT Coronary Angiography in Women and Men With Stable Angina and Non-obstructive Coronary Artery Disease - Analysis From the NORIC Registry

Conditions
-----------------
Coronary Artery Disease, Plaque, Atherosclerotic

Intervention / Treatment
-----------------
* Diagnostic Test: Coronary artery plaque assessment by CT coronary angiography QAngio CT RE


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Stable angina Non-obstructive coronary artery disease by CT coronary angiography defined as <50% stenosis (lumen diameter reduction) Exclusion Criteria: Obstructive coronary artery disease Unstable angina Previous myocardial infarction, heart surgery or percutaneous coronary interventions

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| High and low coronary artery plaque burden<br>Patients with high plaque burden defined as plaque in >=4 segments of the coronary tree and low plaque burden as plaque in <4 segments of the coronary tree assessed by postprocessing of CT coronary angiography images and cardiovascular events and mortality. | Diagnostic Test: Coronary artery plaque assessment by CT coronary angiography QAngio CT RE<br>* Assessment of segmental plaque volume and composition<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cardiovascular mortality and nonfatal acute myocardial infarction | Composite of deaths caused by cardiovascular disease and nonfatal acute myocardial infarction | 5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| All-cause mortality, hospitalization due to cardiovascular disease and revascularization procedures | All-cause mortality, hospitalization due to cardiovascular disease and revascularization procedures | 5 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
coronary artery disease, plaque burden, prognosis