Head Mount Display-based Virtual Reality Rehabilitation of Hemispatial Neglect

Study Overview
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Brief Summary
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Head-mounted display based virtual reality rehabilitation for hemispatial neglect.

Detailed Description
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The investigators examine about the efficacy of field-of-regard-focused visual exploration therapy implemented using a head-mounted display virtual reality system for hemispatial neglect rehabilitation following stroke.

Official Title
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Virtual Reality Based Visual Perception Evaluation and Rehabilitation-pilot Study

Conditions
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Stroke, Neglect, Hemispatial

Intervention / Treatment
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* Device: field of regard-focused visual exploration therapy
* Other: conventional therapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: presence of left hemispatial neglect as demonstrated by a score above the cut-off on the line bisection test or star cancellation test of the Behavioral Inattention Test, or mild-to-moderate neglect-related functional impairment defined by a score of 1-20 points on the Catherine Bergego Scale age 19 to 65 years first-time right hemispheric ischemic or haemorrhagic stroke as evidenced by brain imaging and medical records a score >25 on the Mini-Mental State Examination Exclusion Criteria: presence of oculomotor palsies or visual defects as assessed via standard neurological examination orthopaedic disorders affecting neck movement inability to maintain a seated position.

Ages Eligible for Study
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Minimum Age: 19 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Training first<br>This group completed 20 sessions of a field of regard-focused visual exploration therapy program using an head mount display (five daily sessions per week over a period of four weeks) in addition to conventional therapy followed by four weeks of conventional therapy | Device: field of regard-focused visual exploration therapy<br>* field of regard-focused visual exploration therapy in addition to conventional therapy<br>* Other names: head mount display;Other: conventional therapy<br>* conventional therapy for stroke rehabilitation<br>|
| Other: Waiting first<br>This group completed four weeks of conventional therapy followed by 20 sessions of a field of regard-focused visual exploration therapy program using an head mount display (five daily sessions per week over a period of four weeks) in addition to conventional therapy. | Device: field of regard-focused visual exploration therapy<br>* field of regard-focused visual exploration therapy in addition to conventional therapy<br>* Other names: head mount display;Other: conventional therapy<br>* conventional therapy for stroke rehabilitation<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Field of regard-response time | time interval between target onset and response with field of regard setting | Baseline, 4 weeks from baseline, 8 weeks from baseline | 
| Change in Field of regard-success rate | percentage of correct responses (clicking the left or right mouse button in response to a blue or red target, respectively) with field of regard setting | Baseline, 4 weeks from baseline, 8 weeks from baseline | 
| Change in Field of regard-head movement | sum of all quantified head-rotations with field of regard setting | Baseline, 4 weeks from baseline, 8 weeks from baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Field of view-response time | time interval between target onset and response with field of view setting | Baseline, 4 weeks from baseline, 8 weeks from baseline | 
| Field of view-success rate | percentage of correct responses (clicking the left or right mouse button in response to a blue or red target, respectively) with field of view setting | Baseline, 4 weeks from baseline, 8 weeks from baseline | 
| Line bisection test | Participants were asked to bisect the given lines by marking the centre of each line using their preferred or unaffected hand | Baseline, 4 weeks from baseline, 8 weeks from baseline | 
| Star cancellation test | The experimenter crossed out the two small, central stars of the sheet as an example, following which participants were asked to mark the remaining small stars. | Baseline, 4 weeks from baseline, 8 weeks from baseline | 
| Catherine Bergego Scale | a standardised checklist designed to detect the degree of neglect during everyday life via direct observation of functioning during ten tasks | Baseline, 4 weeks from baseline, 8 weeks from baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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stroke, neglect, virtual reality, head mount display, rehabilitation