Predictive Value of Sublingual Microcirculation and Peripheral Tissue Oxygen Monitoring

Study Overview
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Brief Summary
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Change and predictive Value of Sublingual Microcirculation and Peripheral Tissue Oxygen Monitoring in Sepsis Patients With Successful Fluid Resuscitation

Detailed Description
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Fluid therapy for sepsis patients has always been a research hotspot. Early studies suggest that early goal-directed therapy (EGDT) can reduce mortality in patients with sepsis and septic shock, which is included in the guidelines. However, recent studies suggest that EGDT does not reduce mortality. This may be related to the fact that EGDT only pays attention to systemic circulation and neglects microcirculation. In the past few decades, arterial blood pressure, blood lactic acid and other circulatory indicators have been the target of septic shock treatment, but normal systemic circulation does not mean normal tissue perfusion. Obstacles to tissue perfusion, oxygenation and microcirculation may still exist. At the same time, compared with systemic hemodynamic parameters, microcirculation parameters may play a stronger role in predicting the prognosis of sepsis patients. It is believed that the ideal goal of resuscitation therapy for sepsis should be based on whether microcirculation function has been restored or not. Objective:to observe the success rate of microcirculation imaging and oxygen saturation of peripheral tissues in sepsis patients under the guidance of current guidelines and procedures. At the same time, we compared the predictive value of microcirculation indicators to the prognosis of septic shock patients.

Official Title
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Predictive Value of Sublingual Microcirculation and Peripheral Tissue Oxygen Monitoring in Sepsis Patients With Successful Fluid Resuscitation

Conditions
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Sepsis

Intervention / Treatment
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* Diagnostic Test: NIRS
* Diagnostic Test: Sublingual microcirculation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients fullfilled the diagnostic criteria of Sepsis 3.0 Exclusion Criteria: Patients who were younger than 18 years old， pregnant women patients who had been admitted to the Intensive Care Unit(ICU for<24 h)

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Compliance group<br>6hLC≥10% NIRS Sublingual microcirculation | Diagnostic Test: NIRS<br>* Near-infrared spectroscopy (NIRS) offers non-invasive, in-vivo, real-time monitoring of tissue oxygenation. Changes in regional tissue oxygenation as detected by NIRS may reflect the delicate balance between oxygen delivery and consumption.<br>Diagnostic Test: Sublingual microcirculation<br>* The sidestream dark field (SDF) imaging devices provide high contrast images of the microvasculature.<br>|
| Non compliance group<br>6hLC<10% | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sepsis Related Organ Failure Assessment | SOFA | 72 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 28-day mortality | mortality | 28-day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Sepsis, NIRS, sublingual microcirculation