linjc16/ctgov huggingface dataset:
Risk Factors of Conversion From Local to General Sedation in Endovascular Stroke Therapy

Study Overview
=================
Brief Summary
-----------------
Thrombectomy is now the standard of care of revascularization in acute ischaemic stroke. Data tend to show that final neurologic outcome is superior if the thrombectomy procedure was performed under conscious sedation. The Rothschild Foundation is a high output centre with more than 400 thrombectomy procedures every year. We report a rate of 5% of these procedures requiring general anesthesia despite conscious sedation being the standard of care. This study aims to identify clinical factors associated with a risk of conversion of a conscious sedation to a general anesthesia.

Official Title
-----------------
Search for Risk Factors of Conversion From Local to General Sedation in Emergency Endovascular Therapy for Acute Stroke

Conditions
-----------------
Acute Stroke

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients undergoing thrombectomy for ischemic stroke age ≥ 18 years old Exclusion Criteria: patient already under general anesthesia general sedation required haemorrhagic softening diagnosed before the beginning of procedure patient refusal to participate in the study

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| General Sedation<br>Case patients: Endovascular Acute Stroke Therapy scheduled to be performed under local sedation and finally performed under General anesthesia | |
| local sedation<br>Control patients: Endovascular Acute Stroke Therapy scheduled to be performed, and actually performed under conscious Sedation | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| factors associated with a conversion from conscious sedation to general anesthesia | recording of the procedures during anesthesia | during therapy (day 1) |
Evolution of Pulmonary Capillary Blood Volume

Study Overview
=================
Brief Summary
-----------------
The purpose of this monocentric, preliminary study is to assess the evolution of pulmonary capillary blood volume (Vc), measured by the double diffusion nitric oxide/carbon monoxide (NO/CO) method (Guenard et al.; Respir Physiol 1987), from the starting of the anticoagulant therapy to 6 months after, and to search correlations with the evolution of clinical (dyspnea and results of the 6 minutes walking test), biological (BNP; Troponin), echocardiographic (right ventricular dysfunction, pulmonary arterial pressure) and ventilation/perfusion lung scan data.

Official Title
-----------------
Evolution of Pulmonary Capillary Blood Volume (Vc) in Patients After a First Episode of Pulmonary Embolism.

Conditions
-----------------
Pulmonary Embolism

Intervention / Treatment
-----------------
* Other: diffusion NO/CO method


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patient with a first episode of symptomatic pulmonary embolism, treated with anticoagulant Age from 18 to 75 years-old Exclusion Criteria: Confirmed pulmonary embolism in the past Massive pulmonary embolism, thrombolytic treatment Confirmed left heart systolic dysfunction Confirmed asthma, chronic obstructive pulmonary disease or pulmonary fibrosis Expected life below 6 months Pleural effusion with indication of evacuation Bronchopulmonary cancer Pulmonary surgery with resection of two lobes minimum Predictable incapacity to complete the 6 minutes walking test

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| patients after a first episode of pulmonary embolism<br> | Other: diffusion NO/CO method<br>* pulmonary capillary blood volume (Vc), measured by the double diffusion NO/CO method: this method is to inhale during a deep inspiration with a mixture of helium (8-10%), CO (2000 ppm) and NO (20-40 ppm), the O2 (21%)<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| difference of pulmonary capillary blood volume (Vc) from J0 to 6 months |  | from the starting of the anticoagulant therapy to 6 months after | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| correlations with the evolution of clinical (dyspnea and results of the 6 minutes walking test), biological (BNP; Troponin), echocardiographic (right ventricular dysfunction, pulmonary arterial pressure) and ventilation/perfusion lung scan data |  | from the starting of the anticoagulant therapy to 6 months after | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
pulmonary embolism, pulmonary capillary blood volume, double diffusion NO/CO method
Measurement of Ocular Tensional Fluctuation by Triggerfish Lens Before and After Cataract Surgery in Patients With Exfoliative Glaucoma

Study Overview
=================
Brief Summary
-----------------
Glaucoma is a very frequent disease in Brittany. In glaucoma the retinal ganglion cells and their axons slowly die with visible changes at the optic nerve head (cupping). Without early diagnosis and effective treatment or with delayed treatment decrease of visual acuity or blindness become. In secondary pseudoexfoliation glaucoma grayish-white deposits of abnormal proteins are found on all surfaces of eye irrigated by the aqueous humor. The deposits of PEX material inside the trabecular meshwork decrease aqueous humour outflow and the intraocular pression raise. The exfoliation material is found on the surface of the lens capsule with frequent developement of nuclear cataract . After cataract surgery the intra ocular pressure (IOP) decrease. Some recent study have found decreasing ocular volume variation associated to IOP fluctuation in night after cataract surgery in normal pressure glaucoma patients. In our study we want see if it's the same thing in pseudoexfoliation glaucoma patients.

Conditions
-----------------
Cataract, Exfoliative Glaucoma

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adult Exfoliative glaucoma Patient who need cataract surgery Patient agree with study Exclusion Criteria: Monophtalm patient Patient with bleb after glaucoma surgery Terminal glaucoma Herpes One year control impossible

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measurement of ocular tensional fluctuation by Triggerfish lens before and after cataract surgery in patients with exfoliative glaucoma. | Variation of ocular volume | During 24H00 before and after cataract surgery | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
exfoliative glaucoma, cataract, ocular pressure
Treatment for Specific Phobias in Children

Study Overview
=================
Brief Summary
-----------------
This study will compare the effectiveness of three treatments in reducing symptoms of phobia in children and adolescents.

Detailed Description
-----------------
Children with specific phobias may experience academic, social, and personal distress, as well as interference in day-to-day activities. One-Session Treatment has been found a rapid and effective treatment for adults with phobic disorders. However, its utility in the treatment of childhood phobia has not been examined. Participants are randomly assigned to 1 of 3 groups: a one-session treatment group, an education/support group, and a waitlist control group. The one-session treatment group is directly exposed to a phobia object or situation during a 3-hour treatment session. In the education/support group, children are given information about fear and phobias and are taught how to deal with them through workbook activities. Children who participate in the one-session treatment group or the education/support group are assessed 1 week post-treatment and again after 6 months. Participants with improved symptoms have a 1-year follow-up. Participants with phobias that persist at 6 months are encouraged to participate in alternative treatment. Waitlist control participants are assessed pre-treatment and 1 month post-treatment. Those who continue to have phobias at the 1-month assessment are randomly assigned to 1 of the 2 active treatments.

Official Title
-----------------
One-Session Treatment for Specific Phobias in Children

Conditions
-----------------
Phobic Disorders, Anxiety Disorders

Intervention / Treatment
-----------------
* Behavioral: One-Session Treatment for Specific Phobias


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Primary diagnosis of specific phobia disorder Exclusion Criteria: Mental retardation Developmental disabilities Suicide threat

Ages Eligible for Study
-----------------
Minimum Age: 7 Years
Maximum Age: 16 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: One-Session Treatment for Specific Phobias|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Description of Lymphatic Damage in Encephalic Venous Thrombosis and Strictures in MRI a Reverse-recovery Sequence: a Pilot Study

Study Overview
=================
Brief Summary
-----------------
Inclusion (J0): Information Verification of inclusion and non-inclusion criteria Collection of consent MRI examination with injection of contrast product as part of the treatment comprising the sequences: T1 TFE 1.0 iso 3D FLAIR injected Injected elliptical venous angiography 0.4mm iso or less 3D SWIp multiecho 3D T1 injected FABIR iso without injection (added as part of care in case of suspected ASH or meningitis) FLAIR 1.0 without injection (added as part of care for suspected ASH or meningitis) T2 BFFE XD (added by search) FABIR iso injected (added by research) 3D PD T1 0.55 MSDE iso injected (added by research) Clinical information (SRM on inclusion, on discharge and at 3 months and recurrence within the year) will be collected from the patient's medical file

Official Title
-----------------
Description of Lymphatic Damage in Encephalic Venous Thrombosis and Strictures in MRI a Reverse-recovery Sequence: a Pilot Study

Conditions
-----------------
Description of Local Modifications of Lymph Nodes or Bundles With the FABIR Sequence in MRI

Intervention / Treatment
-----------------
* Other: MRI sequences


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients over 18 years of age Performing an MRI injected as part of care for one of the following reasons: suspicion of pathology likely to be associated with narrowing or obstruction of one or more venous sinuses (cerebral thrombophlebitis, tissue damage with venous extension, idiopathic HIC venous narrowing or obstruction proven by one of the above pathologies, requiring as part of routine care an injected MRI (search for impact, monitoring, pre-therapeutic assessment or prognosis) Express consent to participate in the study Affiliate or beneficiary of a social security scheme Exclusion Criteria: Absolute contraindication to MRI Patient benefiting from a legal protection measure Pregnant or breastfeeding woman

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: MRI sequences|perform additional sequences added by research|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Using a new MRI sequence for the detection of lymph nods | Inversion recovery pulse sequences in MRI will be used to detect lymph nods. | 1 DAY |
FLT-PET for Early Detection of Relapse in Patients With Irradiated Lung Cancer

Study Overview
=================
Brief Summary
-----------------
This study investigates the feasibility of FLT-PET to improve the diagnosis of relapse in patients with irradiated lung cancer in comparison with FDG-PET/CT.

Official Title
-----------------
FLT-PET for Early Detection of Relapse in Patients With Irradiated Lung Cancer

Conditions
-----------------
Lung Cancer, Nonsmall Cell, Small Cell Lung Cancer

Intervention / Treatment
-----------------
* Device: FLT-PET


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: history with lung cancer, small cell or non-small cell radiotherapy of lung cancer ended within the last 24 months radiotherapy might be normofractionated or stereotactic current suspicion of relapse written and oral consent Exclusion Criteria: communication difficulties pregnancy or lactation

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: FLT-PET<br> | Device: FLT-PET<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patients with local and/or regional relapse |  | 6 months |
Psychological Well-being Outcomes in Disease-free Survivors of Colorectal Cancer Following Curative Surgery

Study Overview
=================
Brief Summary
-----------------
The purpose of the study is to investigate whether there are prognostic factors regarding the mental and functional adjustment of colon cancer patients following curative surgery. Patients will be selected using specific inclusion criteria. Prognostic factors investigated include personality characteristics, initial distress, medical, social and economic factors. The utmost purpose of the study is to assist clinicians with the timely identification of vulnerable patients in order to ensure their proper management and their optimal adjustment. Moreover this is the first study using the Distress Thermometer in Greek patients with cancer.

Official Title
-----------------
Psychological Well-being Outcomes in Disease-free Survivors of Colorectal Cancer Following Curative Surgery

Conditions
-----------------
Adaptation, Psychological, Functional Insufficiency

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with first-diagnosed colon cancer. Age 18-60 years Exclusion Criteria: Metastatic colon cancer. Former psychiatric history. Substance use. Previous serious medical conditions.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients<br>Inclusion criteria: Patients with first-diagnosed colon cancer. Age 18-60 y.o. Exclusion criteria: Metastatic colon cancer. Former psychiatric history. Substance use. Previous serious medical conditions. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Postprandial Lipemia and Glycemia Following a High-Fat Meal

Study Overview
=================
Brief Summary
-----------------
The goal of this clinical trial is to determine the acute effects on postprandial lipemia and glycemia by supplementing a high-fat meal with either white button (WB) or shiitake (SH) mushroom powder in relatively healthy adults, aged 18 to 35.

Official Title
-----------------
Acute Effects of White Button and Shiitake Mushroom Powder Supplementation on Postprandial Lipemia and Glycemia Following a High-Fat Meal

Conditions
-----------------
Hypercholesterolemia, Postprandial Hyperglycemia, Lipid Disorder

Intervention / Treatment
-----------------
* Dietary Supplement: Mushroom Powder


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: generally healthy non-diabetic normal to mildly hypercholesterolemic (Total Cholesterol 200-239 mg/dL and LDL-C 130-159 mg/dL) have BMI <30 or BF% (men <25%, women <32%) no known disease of the liver or gallbladder no documented problems with fat metabolism normal lipemic response to a lipid challenge No known mushroom allergy Exclusion Criteria: diabetic pregnant BMI >30 liver disease gallbladder disease mushroom allergy lipid disorder

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: White Button Mushroom<br>368.5 grams of irradiated ground beef patty (80/20 lean mass to fat ratio) + 14 grams white button mushroom powder, and a Wegmans Food Market Brand Big Hawaiian bun | Dietary Supplement: Mushroom Powder<br>* Ground shiitake mushrooms or ground white button mushrooms<br>|
| Experimental: Shiitake Mushroom<br>368.5 grams of irradiated ground beef patty (80/20 lean mass to fat ratio) + 14 grams Shiitake mushroom powder, and a Wegmans Food Market Brand Big Hawaiian bun | Dietary Supplement: Mushroom Powder<br>* Ground shiitake mushrooms or ground white button mushrooms<br>|
| No Intervention: Control<br>368.5 grams of irradiated ground beef patty (80/20 lean mass to fat ratio) and a Wegmans Food Market Brand Big Hawaiian bun. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postprandial Lipemia | Total cholesterol, LDL, HDL, triglycerides | Baseline, up to 6 hours postprandial | 
| Postprandial Glycemia | blood glucose | Baseline, up to 6 hours postprandial | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
mushroom, lipid metabolism, postprandial lipemia, postprandial glycemia
A Comparison of PRK and LASIK for Correction of Myopia

Study Overview
=================
Brief Summary
-----------------
The study compares the precision and accuracy of two laser refractive techniques, PRK and LASIK, for correction of nearsightedness between -6 and -8 diopters.

Official Title
-----------------
A Prospective, Randomised Trial of Photo-Refractive Keratectomy (PRK) and Laser-in-Situ-Keratomileusis (LASIK) for Correction of Myopia

Conditions
-----------------
Myopia

Intervention / Treatment
-----------------
* Procedure: PRK
* Procedure: LASIK


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: spherical equivalent subjective refraction between -6.00 and -8.00 diopters age between 18 and 49 years desire for having laser refractive surgery Exclusion Criteria: present or past eye disease excluding myopia pregnant or lactating woman

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 49 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: PRK|nan|
|Procedure: LASIK|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Uncorrected visual acuity |  |  | 
| Best corrected visual acuity |  |  | 
| Best spectacle correction |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| IOP |  |  | 
| Corneal thickness |  |  | 
| Corneal wavefront aberrations |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Excimer laser