Physical and Mental Assessment of Older Patients With Newly Diagnosed Acute Myeloid Leukemia

Study Overview
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Brief Summary
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RATIONALE: Learning about physical ability and mental function over time in older patients with acute myeloid leukemia may help doctors learn about the long-term effects of treatment and plan the best treatment. PURPOSE: This clinical trial is assessing physical and mental status in older patients with newly diagnosed acute myeloid leukemia.

Detailed Description
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OBJECTIVES: Primary Test the feasibility of pre-treatment, bedside assessment of functional and cognitive status in older adults with newly diagnosed acute myeloid leukemia (AML). Secondary Obtain preliminary data regarding the predictive value of pre-treatment, bedside assessment of functional and cognitive status on overall survival, length of hospitalization and early death. OUTLINE: This is a prospective study. At baseline, patients complete questionnaires including the Vulnerable Elders Survey (functional status), the Mini-Mental Status Exam (cognition), and the Center for Epidemiologic Studies-Depression. Patients also undergo physical function testing via the Short Physical Performance Battery and hand grip strength. Further information parameters are obtained by periodic medical chart reviews. Patients are followed every 3 months for up to 2 years.

Official Title
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Inpatient Functional and Cognitive Assessment in Older Adults With Acute Myelogenous Leukemia

Conditions
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Cognitive/Functional Effects, Depression, Leukemia

Participation Criteria
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Eligibility Criteria
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DISEASE CHARACTERISTICS: Pathologically confirmed newly diagnosed acute myeloid leukemia Planned induction chemotherapy Inpatient status PATIENT CHARACTERISTICS: No requirement for intensive care unit support PRIOR CONCURRENT THERAPY: See Disease Characteristics No prior therapy for acute myeloid leukemia

Ages Eligible for Study
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Minimum Age: 60 Years
Maximum Age: 120 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| patients admitted with acute leukemia<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| feasibility of administering a functional assessment in clinical situation | Assessment of physical and cognitive function via a set of physical and congnitive tests | 72 hours of admission | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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depression, cognitive/functional effects, untreated adult acute myeloid leukemia, adult acute myeloid leukemia with 11q23 (MLL) abnormalities, adult acute myeloid leukemia with inv(16)(p13;q22), adult acute myeloid leukemia with t(15;17)(q22;q12), adult acute myeloid leukemia with t(16;16)(p13;q22), adult acute myeloid leukemia with t(8;21)(q22;q22)