Analgesia After Video-Assisted Thoracic Surgery

Study Overview
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Brief Summary
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Although less invasive, postoperative analgesia remains challenging in patients undergoing uniportal video-assisted thoracic surgery (VATS).

Detailed Description
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Although less invasive, postoperative analgesia remains challenging in patients undergoing uniportal video-assisted thoracic surgery (VATS). Adequate postoperative pain relief is imperative to hasten functional recovery, accelerate discharge from the hospital, and reduce chronic postsurgical pain.

Official Title
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Analgesic Efficacy of Ultrasound-Guided Deep Serratus Anterior Plane Block, Local Wound Infiltration, and Thoracic Paravertebral Block After Uniportal Video-Assisted Thoracic Surgery: A Randomized Trial

Conditions
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Post Operative Pain

Intervention / Treatment
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* Drug: Ultrasound-guided deep serratus anterior plane block with isobaric bupivacaine
* Drug: Local wound infiltration with isobaric bupivacaine
* Drug: Ultrasound-guided thoracic paravertebral block with isobaric bupivacaine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients scheduled for uniportal VATS under general anesthesia, ASA status I-III, aged from 18 to 70 years old of both sex. Exclusion Criteria: Contraindications to regional block Pregnancy Body mass index (BMI) > 30 Kg/m2 Psychiatric diseases Severe renal, liver, or cardiac dysfunction

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Group I<br>Patients will receive ultrasound-guided deep serratus anterior plane block. | Drug: Ultrasound-guided deep serratus anterior plane block with isobaric bupivacaine<br>* Patients will receive ultrasound-guided deep serratus anterior plane block with isobaric bupivacaine.<br>|
| Active Comparator: Group II<br>Patients will receive local wound infiltration (LWI). | Drug: Local wound infiltration with isobaric bupivacaine<br>* Patients will receive local wound infiltration with isobaric bupivacaine.<br>|
| Placebo Comparator: Group III<br>Patients will receive ultrasound-guided thoracic paravertebral block. | Drug: Ultrasound-guided thoracic paravertebral block with isobaric bupivacaine<br>* Patients will receive ultrasound-guided thoracic paravertebral block with isobaric bupivacaine.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time to first analgesic requirement | Assessed in minutes | 24 hours after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative pain intensity | Assessed by the numerical rating pain scale, an 11-point scale graded from 0 to 10 (0 = no pain, 10 = the worst imaginable pain) | 24 hours after surgery |