Aerobic Versus Combined Exercise and Diastolic Dysfunction

Study Overview
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Brief Summary
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Thirty-two stable patients with chronic heart failure participated in an exercise rehabilitation program. They randomly assigned to aerobic exercise (AER) or combined aerobic and strength training (COM). Before and after the program, they underwent a symptom-limited maximal cardiopulmonary exercise testing and serial echocardiography evaluation examining the indices of diastolic dysfunction (DD).

Detailed Description
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Thirty-two stable patients with chronic heart failure (age: 56 ± 10 years, EF: 32 ± 8%, 88 % men) participated in an exercise rehabilitation program. They randomly assigned to aerobic exercise (AER) or combined aerobic and strength training (COM), based on age and peak oxygen uptake, as stratified randomization criteria. Before and after the program, they underwent a symptom-limited maximal cardiopulmonary exercise testing (CPET) and serial echocardiography assessment to evaluate peak oxygen uptake (VO2peak), peak workload (Wpeak), DD grade, right ventricular systolic pressure (RVSP) and EF.

Official Title
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Effects of Exercise Training on Diastolic and Systolic Dysfunction in Patients With Chronic Heart Failure

Conditions
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Diastolic Dysfunction, Heart Failure

Intervention / Treatment
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* Other: aerobic exercise
* Other: combined exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: chronic heart failure Exclusion Criteria: atrial fibrillation COPD

Ages Eligible for Study
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Minimum Age: 36 Years
Maximum Age: 71 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: aerobic exercise<br>effects on diastolic dysfunction in patients with stable chronic heart failure | Other: aerobic exercise<br>* exercise training rehabilitation (aerobic exercise with/without strength training)<br>Other: combined exercise<br>* exercise training rehabilitation (aerobic exercise with/without strength training)<br>|
| Active Comparator: Combined exercise<br>effects on diastolic dysfunction in patients with stable chronic heart failure | Other: aerobic exercise<br>* exercise training rehabilitation (aerobic exercise with/without strength training)<br>Other: combined exercise<br>* exercise training rehabilitation (aerobic exercise with/without strength training)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluation of the impact of a cardiac rehabilitation program on the diastolic dysfunction in patients with chronic heart failure | Thirty-two stable patients with chronic heart failure (age: 56 ± 10 years, EF: 32 ± 8%, 88 % men) participated in an exercise rehabilitation program. They randomly assigned to aerobic exercise (AER) or combined aerobic and strength training (COM), based on age and peak oxygen uptake, as stratified randomization criteria. Before and after the program, they underwent a serial echocardiography assessment to evaluate the diastolic dysfunction (DD) grade of the left ventricular. | three months | 
| Evaluation of the impact of a cardiac rehabilitation program on the ejection fraction of the left ventricular in patients with chronic heart failure | Thirty-two stable patients with chronic heart failure (age: 56 ± 10 years, EF: 32 ± 8%, 88 % men) participated in an exercise rehabilitation program. They randomly assigned to aerobic exercise (AER) or combined aerobic and strength training (COM), based on age and peak oxygen uptake, as stratified randomization criteria. Before and after the program, they underwent a serial echocardiography assessment to evaluate the ejection fraction of the left ventricular. | three months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluation of the impact of a cardiac rehabilitation program on the indices of aerobic exercise capacity of the left ventricular in patients with chronic heart failure | Thirty-two stable patients with CHF (age: 56 ± 10 years, EF: 32 ± 8%, 88 % men) participated in an exercise rehabilitation program. They randomly assigned to aerobic exercise (AER) or combined aerobic and strength training (COM), based on age and peak oxygen uptake, as stratified randomization criteria. Before and after the program, they underwent a cardiopulmonary exercise test to evaluate VO2peak and Wpeak | three months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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diastolic dysfunction, exercise training