Evolution of DMDD Children and Adolescent

Study Overview
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Brief Summary
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Little is known about the natural course and prognosis factors of inpatients and outpatients with Disruptive Mood Dysregulation Disorder (DMDD). The investigators conducted a cross-sectional study to determine the evolution of a sample of DMDD patients referred to the hospital for suicidal behaviors between 2013 and 2018 in terms of diagnostic stability, psychiatric comorbidity, and psychosocial factors. A group of patients with various episodic mood disturbances was used as a clinical case control group. In addition to change in DMDD symptoms across time, the investigators examined the onset and persistence of psychiatric comorbidity using the KIDDIE-SADS PL and suicidal behaviors using the Colombia Suicidality Severity Rating Scale. The investigators also examined the persistence of depressive symptoms using the Beck Depression Inventory (BDI-II), the persistence of emotional lability (Affective Lability Scale-18), borderline traits (Abbreviated Diagnostic of Inventory Borderline). Socio-demographic, clinical features and actigraphy-measured sleep characteristics determined between 2013 and 2018 were used to predict the evolution of the DMDD patients and the clinical control group.

Official Title
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Evolution of Children and Adolescents With Disruptive Mood Dysregulation Disorder Refereed to Hospital for Suicidal Behavior After Three Year: Diagnostic Stability, Psychiatric Comorbidity, Psychosocial Functioning, Identification of Clinical and Actigraphy-measured Prognosis Factors

Conditions
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Disruptive Mood Dysregulation Disorder, Prognosis Factors, Suicidal Behaviors, Actigraphy

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Boys and girls between 10 and 25-year-old patients who had been referred to the university hospital of Amiens for suicidal behaviors between 2013 and 2018 patients who participated to the study Clinical and actigraphy-measured profiles of inpatient youths with suicidal behavior: exploration of the severe mood dysregulation Exclusion Criteria: No affiliation to a social security service Persons deprived of their liberty as stipulated in article L.1121-6 of the Public Health Code

Ages Eligible for Study
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Minimum Age: 10 Years
Maximum Age: 25 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| various episodic mood disturbances patient group<br>A group of patients with various episodic mood disturbances was used as a clinical case control group. | |
| Disruptive Mood Dysregulation Disorder (DMDD) patient group<br>DMDD patients referred to the hospital for suicidal behaviors between 2013 and 2018 in terms of diagnostic stability, psychiatric comorbidity, and psychosocial factors. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diagnostic evolution toward an other psychiatric disorder. | The evolution toward another psychiatric disorder would be examined using the semi-structured interview KIDDIE-SADS and the Ab-DIB to examine borderline traits. The K-SADS is a semi-structured interview to measure current and past symptoms of mood, anxiety, psychotic, and disruptive behavior disorders in children ages 6-18 years old. (Ab-DIB) as a screening measure of borderline psychopathology in an adolescent clinical population. | one day | 
| persistence of a full-blown DMDD diagnostic | The persistence of a full-blown DMDD diagnostic would be defined using the DSM-5 criteria. Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) is the 2013 update to the Diagnostic and Statistical Manual of Mental Disorders, the taxonomic and diagnostic tool published by the American Psychiatric Association. | one day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Disruptive Mood Dysregulation Disorder, prognosis factors, natural course, suicidal behaviors, actigraphy, pediatric depressive disorder