The Effects of General Anesthesia on Microcirculation of Central and Peripheral Soft Tissue: a Comparison of Inhalational and Intravenous Anesthetics

Study Overview
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Brief Summary
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Effects of different general anesthetics on peripheral microcirculation.

Detailed Description
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Human keep body temperature in a narrow range by a variety of regulatory mechanism. Peripheral thermal receptors send signals to central nervous system which regulate body temperature via peripheral effectors, such as vasoconstriction, vasodilatation, shivering, sweating and etc. In patients undergoing general anesthesia, the regulatory mechanism is altered. General anesthesia changes blood distribution in the body, the metabolic rate of muscle, threshold of thermal regulation in the brain and etc, so that heat distribution and microcirculation condition will also change. In this study, near-infrared spectroscopy (NIRS) is used to measure the microcirculatory condition. NIRS is a non-invasive continuous measurement to detect tissue saturation with the method of different wavelength of near-infrared. General anesthesia with inhalational sevoflurane and intravenous propofol is separated into 2 groups. Because of different mechanism of general anesthesia of these 2 anesthetics, different physiologic response may occur. Body temperature and somatic saturation are compared in each group.

Official Title
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The Effects of General Anesthesia on Microcirculation of Central and Peripheral Soft Tissue: a Comparison of Inhalational and Intravenous Anesthetics

Conditions
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Microcirculatory Effects of Anesthesia, Inhalation and Intravenous Anesthesia

Intervention / Treatment
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* Drug: Propofol
* Drug: Sevoflurane
* Procedure: General anesthesia induction


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Breast surgeries under general anesthesia BMI 18.5 30 Exclusion Criteria: Cardiac disease Lung disease Renal disease Neurological disease Autonomic nervous system dysfunction

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Sevoflurane anesthesia<br>Anesthesia maintained with inhalational sevoflurane | Drug: Sevoflurane<br>* General anesthesia maintained with inhalational sevoflurane<br>Procedure: General anesthesia induction<br>* Induce routine of general anesthesia, including propofol 1-3mg/kg, fentanyl 1-3mcg/kg, cisatracurium 0.2-0.3mg/kg.<br>|
| Experimental: Propofol anesthesia<br>Anesthesia maintained with intravenous propofol continuous infusion | Drug: Propofol<br>* General anesthesia maintained with intravenous propofol infusion<br>Procedure: General anesthesia induction<br>* Induce routine of general anesthesia, including propofol 1-3mg/kg, fentanyl 1-3mcg/kg, cisatracurium 0.2-0.3mg/kg.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Somatic saturation | Change of somatic saturation measured by NIRS | during surgery, approximately 2-4 hr | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Body temperature | Nasal and peripheral temperature | during surgery, approximately 2-4 hr | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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microperfusion, temperature, near-infrared spectroscopy, anesthesia, total intravenous anaesthesia