The Effect of Entonox on Stages of Labor in Nulliparous Women

Study Overview
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Brief Summary
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This Trial study about The effect of Entonox associated with duration of labor in Active phase and efficacy for relief pain of labor .So investigators start to study up to 14 months

Detailed Description
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Investigators will enroll participants in 2 groups by randomized . First group will inhale Entonox and the second group not receive any gas . The participants in Entonox group will inhale gas in 4-5 times for each uterine contraction and Nurse will measure blood pressure , O2 saturation ,pain score before use gas . The outcome,investigators study about Apgar score , duration of labor , pain relief in both group,route of delivery and estimated blood loss

Official Title
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The Effect of Entonox on Stages of Labor in Nulliparous Women :a Randomized Controlled Trial

Conditions
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ENTONOX, Nulliparous, Duration of Labor

Intervention / Treatment
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* Drug: Entonox
* Drug: Not receive Entonox


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Nulliparity Age 18 years old or more Gestational age 37-40+6 wks Singleton Cephalic presentation Cervical dilatation > 5 cm Estimated fetal weight 2,500-4,000 gm Exclusion Criteria: Estimated fetal weight more than 4,000 gm High risk pregnancy (Hypertension in pregnancy ,Endocrine disorder , autoimmune disorder , epilsepsy etc) SpO2 < 95 % Contraindication for Entonox usage ( Severe head injury , asthma , Pulmonary disease,Otitis media ) Drug allergy : Metoclopramide , Dimenhydrinate , Pethidine ,Entonox

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Entonox<br>Inhalation Entonox in active phase of labor ( cervical dilatation more than 5 cm ) Inhaled Entonox before true uterine contraction in 30 sec , inhaled in 4-5 times for 1 contraction | Drug: Entonox<br>* Entonox gas with mouth piece<br>* Other names: Entonox gas;|
| Active Comparator: Not receive Entonox<br>Not receive any gas when archive in active phase of labor( cervical dilatation more than 5 cm ) | Drug: Not receive Entonox<br>* Not receive any gas<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Effect of Entonox for duration of labor | Study about duration of labor after receive Entonox in active phase of labor | up to 14 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of patients who inhaled Entonox for pain relieve | % of patients relieve pain after inhaled Entonox , Investigators measure by visual analogue scale | up to 14 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Entonox, Nulliiparous