Preoperative Percutaneous Radiofrequency Ablation of Primary and Secondary Lung Tumors

Study Overview
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Brief Summary
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The purpose of the study is to evaluate the effectiveness of radiofrequency ablation by pathological correlation and to characterize the tissue response after treatment of primary and secondary pulmonary tumors.

Detailed Description
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Thermal ablation therapy is an increasingly performed technique in the local tumor treatment. Among these techniques, image-guided radiofrequency (RF) ablation attained widespread consideration in the therapy of liver tumors and osteoid osteoma. Promising results of hepatic RF ablation raised expectations to utilize the advantages of image-guided ablation therapy for the treatment of pulmonary malignancies. The purpose of the study is to evaluate the effectiveness of radiofrequency ablation by pathological correlation and to characterize the tissue response after treatment of primary and secondary pulmonary tumors. Computed tomography-guided RF ablation is performed in local or general anesthesia, followed by surgical resection three days later. An analysis of complete RF ablation and a characterization of tissue response is performed by hematoxylin and eosin staining, immunostaining, and electron microscopy. Adverse effects and complications are recorded.

Official Title
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Evaluation of Effectiveness of Preoperative Percutaneous Radiofrequency Ablation of Primary and Secondary Lung Tumors

Conditions
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Lung Cancer, Lung Metastasis

Intervention / Treatment
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* Procedure: pulmonary radiofrequency ablation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Signed informed consent for radiofrequency ablation and surgery Maximum of 3 lung tumors Maximum tumor size 5 cm Must be able to receive standard surgery Exclusion Criteria: Pathological coagulation tests Pregnant or breast feeding Maximum tumor size more than 5 cm Bilateral secondary lung cancer with more than 3 tumors Inoperable patient

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>pulmonary radiofrequency ablation | Procedure: pulmonary radiofrequency ablation<br>* CT-guided pulmonary radiofrequency ablation<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| rate of incomplete treated tumors |  | 3 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| pathologic tissue changes, rate of major and minor complications |  | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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lung cancer, lung metastasis, radiofrequency ablation