Acute Cognition and Exercise

Study Overview
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Brief Summary
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The central hypothesis is that, while both groups will benefit from the exercise session, participants with obesity will exhibit greater gains in cognitive control, relative to healthy weight adults. Additionally, it is anticipated that the benefits of a single bout of exercise for cognitive control will be mediated by changes in exercise-induced myokines. These hypotheses will be tested by accomplishing three aims: Aim 1: Elucidate the changes in cognitive control following an acute bout of exercise, relative to a sedentary condition, in persons with and without obesity. Aim 2: To examine the effect of a single bout of exercise, relative to a sedentary condition, on myokines known to have neuroprotective effects i.e., BDNF and CTSB in both healthy weight and individuals with obesity. Aim 3: To link changes in exercise-induced myokines (i.e., BDNF and CTSB) to changes in cognitive function, following a single bout of exercise.

Detailed Description
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18 adults with healthy weight (BMI 18.5-25.0kg/m2) and 18 adults with obesity (BMI 30.0kg/m2) will be asked to complete a counter-balanced crossover trial. After initial baseline testing, participants will be asked to complete either an acute exercise bout or sedentary control session in a counter-balanced order. A cognitive testing battery accompanied by an electroencephalogram (EEG) will be administered following each session. Blood samples will be collected prior to, during, and following each throughout each testing condition.

Official Title
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Acute Exercise and Cognitive Function: Examining the Role of Weight Status and Exercise-Induced Myokines

Conditions
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Obesity

Intervention / Treatment
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* Behavioral: Exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Between ages 18 and 35 No prior diagnosis of neurological disorders (e.g., autism spectrum disorder) No prior diagnosis of metabolic disease (e.g., diabetes, cardiovascular disease) No physical disability that would preclude the participant from completing a VO2max test Corrected vision (based on the minimal 20/20 standard needed to complete cognitive tasks) Not pregnant BMI between 18.5 and 25.0 kg/m2, or BMI greater than 30.0 kg/m2 Readiness for exercise (determined through PAR-Q) Exclusion Criteria: <18 years and >35 years Diagnosis of neurological disorders (e.g., autism spectrum disorder) Diagnosis of metabolic disease (e.g., diabetes, cardiovascular disease) Physical disability that would preclude the participant from completing a VO2max test Lack of corrected vision (based on the minimal 20/20 standard needed to complete cognitive tasks) Pregnancy BMI less than 18.5 kg/m2 or BMI greater than 25.0 but less than 30.0 kg/m2

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Crossover Assignment
Interventional Model Description: 18 adults with healthy weight (BMI 18.5-25.0kg/m2) and 18 adults with obesity (BMI 30.0kg/m2) will be asked to complete a counter-balanced crossover trial. After initial baseline testing, participants will be asked to complete either an acute exercise bout or sedentary control session in a counter-balanced order.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Exercise<br>36 minutes of exercise | Behavioral: Exercise<br>* 36 minutes of Exercise<br>|
| Placebo Comparator: Rest<br>36 minutes of rest | Behavioral: Exercise<br>* 36 minutes of Exercise<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Circulating Cathepsin B (CTSB) Myokine | Changes in peripheral myokine concentration | 3 hours | 
| Attentional Inhibition Accuracy | Behavioral performance measured as accuracy (%) during Flanker task | 3 hours | 
| Attentional Inhibition Reaction Time | Behavioral performance measured as response time (ms) during Flanker task | 3 hours | 
| Attentional Resource Allocation | Changes in P3 event related potential amplitude (microvolts) using a computerized flanker task | 3 hours | 
| Attentional Processing Speed | Changes in P3 event related potential latency (ms) using a computerized flanker task | 3 hours | 
| Relational Memory | Accuracy during a spatial reconstruction task | 3 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Brain derived neurotrophic factor (BDNF) | Changes in peripheral BDNF concentration | 3 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Myokine, Cognition, CTSB, BDNF, Exercise