The Chinese Early-onset Hypertension Study (CHESS)

Study Overview
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Brief Summary
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Hypertension (HTN) is the most important cardiovascular risk factor which is responsible for 50% of cardiovascular morbidity and mortality, and also a substantial public health problem affecting approximately 1/4 of the adult population in industrialized societies and over 1 billion people worldwide. Chronically elevated blood pressure without well control puts people at increased risk of target organ damages, including stroke, myocardial infarction, congestive heart failure, end-stage renal disease, blindness, and death. Especially, these damages are dramatically more severe in the early-onset hypertensive population.

Detailed Description
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In this study, the hypertensive individuals are consecutively recruited from multiple centers, with an early onset age (less than 40 when diagnosed). A complete clinical history (information on history of hypertension, demographic characteristics, personal and family medical history) are collected by a trained staff using a standardized questionnaire on the first day of baseline observation, and physical examination are also collected in a standard procedure. Blood samples are collected after 12-hour overnight fast and biological variables are determined. Genomic DNA is isolated from leukocytes according to a standard procedure. The individuals will receive follow-up in an ordinal system. The investigators will focus on the clinical and genetic features, genotype-phenotype correlations and influencing factors of prognosis in Chinese early-onset hypertension patients.

Official Title
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The Chinese Early-onset Hypertension Study (CHESS)

Conditions
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Hypertension

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: In accordance with the diagnosis of hypertension (BP≥140/90mmHg), and less than 40 years when diagnosed Exclusion Criteria: -
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| early-onset hypertension<br>early-onset hypertension patients recruited in Chinese multiple centers | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| primary mortality of early-onset hypertension | the primary mortality of early-onset hypertension | through study completion, an average of 5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| secondary outcomes of heart | The incidence rate of left ventricular hypertrophy, myocardial infarction, congestive heart failure, and arrhythmia. | through study completion, an average of 5 years | 
| secondary outcomes of brain | The incidence rate of stroke (include cerebral hemorrhage and cerebral ischemia) | through study completion, an average of 5 years | 
| secondary outcomes of kidney | The incidence rate of hypertensive renal injure and end-stage renal disease | through study completion, an average of 5 years | 
| secondary outcomes of eyes | The incidence rate of hypertensive eye injure | through study completion, an average of 5 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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hypertension, early onset, target organ damage