Health, Perception, Practices, Relations and Social Inequalities in the General Population During the Covid-19 Crisis

Study Overview
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Brief Summary
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This study aims to quantify and follow the cumulative incidence of SARS-CoV-2 infection in the French population using serological tests and to assess the determinants of infection from Constances, E3N-E4N, ELFE-Epipage 2 and NutriNet-Santé cohorts.

Detailed Description
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The primary objective is to assess the cumulative incidence of infection in the general population using dried blood spot sampling. The secondary objectives are: To identify factors associated with a positive SARS-CoV-2 infection (positive serology) and to characterize the durability of the serological response to SARS-CoV-2 To identify associations of symptoms predictive of a SARS-CoV-2 infection To estimate the health care use associated with a SARS-CoV-2 infection To estimate the fraction of sub-clinical infections or infections not captured by the healthcare system; To study the acceptability of a mass anti-SARS-CoV-2 serological testing and the impact of its result, linked with social inequalities in health; To estimate the individual and collective impact of containment and other preventive measures on the risk of SARS-CoV-2 infection; To study the impact of social and territorial inequalities on seroprevalence levels.

Official Title
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Health, Perception, Practices, Relations and Social Inequalities in the General Population During the Covid-19 Crisis - Serology

Conditions
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SARS-CoV 2

Intervention / Treatment
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* Biological: Non applicable


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: non applicable, already enrolled in the cohorts Exclusion Criteria: non applicable
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| SAPRIS-SERO<br>SAPRIS-SERO enrolls participants from cohorts entitled: Constances, E3N-E4N, ELFE, Epipage 2 and NutriNet-Santé. | Biological: Non applicable<br>* to collect data from questionnaires and to collect serological samples<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cumulative incidence of SARS-Cov2 infection in the general population. | Simple and corrected estimate of the number of seropositive individuals/number of individuals at risk in different strata, based on weighting and calibration and taking into account the random cohort effect. | 8 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Maintenance over time of the acquisition of anti-SARS-Cov2 antibodies | Decay kinetics estimated by mixed effect model with repeated data per subject | 8 months | 
| Rate of use of care (medical care, hospitalization, center 15) linked to the occurrence of symptoms suggestive of a SARS-Cov2 infection, and share attributable to the infection | Rate of use of care (medical care, hospitalization, center 15) linked to the occurrence of symptoms suggestive of a SARS-Cov2 infection, and share attributable to the infection during a time frame of 8 months | 8 months | 
| Proportion of infections without reported or pauci-symptomatic symptoms and their epidemiological and social determinants | Proportion of infections without reported or pauci-symptomatic symptoms and their epidemiological and social déterminants during a time frame of 8 months. | 8 months | 
| Proportion of tests proposed, accepted, performed, based on social and demographic characteristics | Proportion of tests proposed, accepted, performed, based on social and demographic characteristics during a time frame of 8 months. | 8 months | 
| Proportion and intensity of use of barrier measures (hydroalcoholic gel, mask, social distancing, description of outings / reasons, duration, frequency) and association with the level of seroprevalence | Proportion and intensity of use of barrier measures (hydroalcoholic gel, mask, social distancing, description of outings / reasons, duration, frequency) and association with the level of seroprevalence during a time frame of 8 months | 8 months | 
| Strengths of associations between socio-behavioral factors and level of seroprevalence | Strengths of associations between socio-behavioral factors and level of seroprevalence during a time frame of 8 months | 8 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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cohort, SARS-CoV2, containment, serology, prevention