Spectrum of Serum Sodium Disturbances in Patients With Non-sellar/Suprasellar Supratentorial Tumors

Study Overview
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Brief Summary
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This study was designed to quantify the incidence of hyponatremia in patients of supratentorial/supra-sellar lesions and observe their effect on neurological morbidity and mortality.

Detailed Description
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Disorders of sodium and water balance are one of the commonly encountered problems while managing patients with neurological diseases. Managing such problems are challenging because the pathophysiology behind these disorders are complex and poorly understood and treatment of the injured brain itself can contribute to, and complicate the diagnosis of sodium disorders. Serum sodium disturbance can manifest as hypernatremia or hyponatremia. Hypernatremia usually occurs in the diabetes insipidus syndrome, whereas hyponatremia develops as a syndrome of inappropriate secretion of antidiuretic hormone (SIADH) or cerebral salt-wasting syndrome (CSWS). Because of the cerebral effects of hyponatremia, neurosurgical patients are at increased risk of complications including severe cerebral edema, mental status changes, seizures, vasospasm, and death. Though the problem of hyponatremia has been addressed in patients with different brain pathologies, this has not been studied in patients with non-sellar/suprasellar supratentorial tumors. This study was envisioned to quantify the incidence and magnitude of hyponatremia in this patient population and their subsequent neurological morbidity and mortality.

Official Title
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Spectrum of Serum Sodium Disturbances in Patients With Non-sellar/Suprasellar Supratentorial Tumors

Conditions
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Supratentorial Brain Tumor

Intervention / Treatment
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* Diagnostic Test: Serum Sodium


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients undergoing surgical management for supratentorial/suprasellar tumors. Exclusion Criteria: Glasgow Coma Score (GCS) <4.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Retrospective Cohort<br>Supratentorial/Suprasellar brain tumor patients with Glasgow Coma Score > 3 at time of admission. | Diagnostic Test: Serum Sodium<br>* Measurement of serum sodium.<br>|
| Prospective Cohort<br>Supratentorial/Suprasellar brain tumor patients with Glasgow Coma Score > 3 at time of recruitment. | Diagnostic Test: Serum Sodium<br>* Measurement of serum sodium.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality | To observe relationship between hyponatremia in supratentorial tumor patients and in-hospital mortality. | From date of admission to hospital to date of Discharge from hospital or Death in hospital, whichever comes first, assessed up to 2 years from date of admission. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Duration of hospital stay | To observe relationship between hyponatremia in supratentorial tumor patients and duration of hospital stay. | From date of admission to hospital to date of Discharge from hospital or Death in hospital, whichever comes first, assessed up to 2 years from date of admission. | 
| Rate of admission in intensive care unit. | To observe relationship between hyponatremia in supratentorial tumor patients and rate of admission in intensive care unit. | From date of admission to hospital to date of Discharge from hospital or Death in hospital, whichever comes first, assessed up to 2 years from date of admission. | 
| Neurological deficits | To observe relationship between hyponatremia in supratentorial tumor patients and incidence of neurological deficits. | From date of admission to hospital to date of Discharge from hospital or Death in hospital, whichever comes first, assessed up to 2 years from date of admission. | 
| Seizures | To observe relationship between hyponatremia in supratentorial tumor patients and incidence of seizures. | From date of admission to hospital to date of Discharge from hospital or Death in hospital, whichever comes first, assessed up to 2 years from date of admission. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Hyponatremia, Dysnatremia, Neurosurgery, Neurointensive Care