Periostin and Non-Surgical Periodontal Treatment

Study Overview
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Brief Summary
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A total of 90 subjects, 30 patients with chronic periodontitis, 30 with gingivitis and 30 periodontally healthy subjects were included. Patients with periodontal disease received non-surgical periodontal treatment. Gingival crevicular fluid periostin levels were assessed at baseline, at the 6th week and the 3rd month after treatment.

Detailed Description
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Periostin is commonly found in collagen-rich tissues, which is thought to affect the production of collagen fibers. Additionally, periostin is synthesized in tissues exposed to constant mechanical forces such as the periosteum, periodontal ligament, tendon, heart valve and skin. Periostin mediates inflammation and fibrosis during diseases of various organs, including the heart, lung, kidney, skin, liver, skeletal muscle and retina. This study evaluated periostin levels in gingival crevicular fluid from patients with chronic periodontitis, gingivitis and periodontally healthy as well as the effect of non-surgical periodontal treatment on gingival crevicular fluid periostin levels.

Official Title
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The Effect of Non-Surgical Periodontal Treatment on Gingival Crevicular Fluid Periostin Levels in Patients With Gingivitis and Chronic Periodontitis

Conditions
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Periodontal Diseases

Intervention / Treatment
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* Procedure: Non-Surgical Periodontal Treatment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Clinical diagnosis of chronic periodontitis Clinical diagnosis of gingivitis Clinical diagnosis of periodontal health Exclusion Criteria: have any systemic disease to be alcohol consumer to receive any periodontal therapy in the past 6 months to take any drugs regularly to be pregnant and/or lactate

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Patients with chronic periodontitis<br>Patients with CP (n=30) had teeth with 30% periodontal bone loss and ≥ 2 non-adjacent sites per quadrant with probing depth (PD) ≥ 5 mm and bleeding on probing. | Procedure: Non-Surgical Periodontal Treatment<br>* Scaling and root planing and polishing with specific curettes were performed to patients and oral hygiene education was provided to each patient.<br>* Other names: Initial periodontal therapy;|
| Experimental: Patients with gingivitis<br>Participants with G (n=30) had gingival index ≥ 2 and other inflammation signs. | Procedure: Non-Surgical Periodontal Treatment<br>* Scaling and root planing and polishing with specific curettes were performed to patients and oral hygiene education was provided to each patient.<br>* Other names: Initial periodontal therapy;|
| No Intervention: Participants with periodontal healthy<br>The H group (n=30) consisted of individuals with no attachment loss, no history of periodontal disease, PD ≤3 mm, and whole-mouth bleeding scores <10%. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in periostin | Total amount of Periostin (pg/30 sec) in gingival crevicular fluid | Baseline, 6th week and 3rd month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in periodontal clinical parameter | Clinical attachment level (mm) (from cemento-enamel junction to the base of periodontal pocket) | Baseline, 6th week and 3rd month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Chronic periodontitis, Gingival crevicular fluid, Gingivitis, Non-surgical periodontal treatment, Periostin