The Effect of Home Blood Pressure Measurement on the Management of Hypertension

Study Overview
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Brief Summary
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Home blood pressure measurement has been reported to be associated with better clinic blood pressure and daytime blood pressure control. However, no study has evaluated the association between home blood pressure measurement and control of 24-hour ambulatory blood pressure in real world practice. The purpose of the present study is to investigate the effect of home blood pressure measurement on the control of ambulatory blood pressure in the real world. The detailed purposes of the present study are (1) to investigate the effects of home blood pressure measurement on the appropriate control of 24-hour ambulatory blood pressure in hypertensive patients treated with antihypertensive drug, (2) to evaluate the effect of home blood pressure measurement on the occurrence of cardiovascular events and target organ damage, (3) to investigate the status and appropriateness of home blood pressure measurement in the real world, and (4) to investigate factors of home blood pressure measurement methods affecting the treatment of hypertension.

Official Title
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Evaluation of Home Blood Pressure Measurement for the Management of Hypertension in Treated Hypertensive Patients

Conditions
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Hypertension, Blood Pressure, Home Blood Pressure Measurement, Ambulatory Blood Pressure

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with hypertension and taking antihypertensive drugs more than 1 year Exclusion Criteria: Secondary hypertension Hypertensive emergency and urgency Severe heart failure (NYHA III and IV) Angina with 6 months Myocardial infarction within 6 months Peripheral artery disease within 6 months Significant arrhythmia (i.e. ventricular tachycardia and fibrillation, atrial fibrillation, atrial flutter) Pregnancy Night labor, shift worker Those who are currently participating in other clinical studies Those who have taken other clinical trial drugs within the past month According to the opinion of the researcher, those who have or may have a disease that may interfere with the completion of the study History of drug or alcohol dependence within 6 months

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Difference of 24-hour blood pressure control rate | difference of 24-hour blood pressure control rate between patients who measure and do not measure home blood pressure | at baseline and 3 years of follow up | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Difference of daytime blood pressure control rate | Difference of daytime blood pressure control rate between patients who measure and do not measure home blood pressure | at baseline and 3 years of follow up | 
| Difference of office blood pressure control rate | Difference of office blood pressure control rate between patients who measure and do not measure home blood pressure | at baseline and 3 years of follow up | 
| Difference of systolic and diastolic blood pressure (office, 24-hour, daytime, nighttime) | Difference of systolic and diastolic blood pressure (office, 24-hour, daytime, nighttime) between patients who measure and do not measure home blood pressure | at baseline and 3 years of follow up | 
| Rate of home blood pressure measurement | Rate of home blood pressure measurement in study population | at baseline and 3 years of follow up | 
| Reflection of home blood pressure | Rate of reflecting home blood pressure in the treatment of hypertension at office | at baseline and 3 years of follow up | 
| cardiovascular disease prevalence and target organ damage | Difference of cardiovascular disease prevalence and target organ damage between patient who do or do not measure home blood pressure Composites of cardiovascular disease: number of participants with non-fatal myocardial infarction, angina pectoris, revascularization of arteries, stroke, transient ischemic attack, atrial fibrillation, heart failure hospitalization, progression to end-stage renal failure or elevation of creatinine more than 2-fold, other undefined cardiovascular events at the discretion of the investigator Target organ damage: left ventricular hypertrophy by electrocardiography, brachial-ankle pulse wave velocity, microalbuminuria | at baseline and 3 years of follow up | 
| Changes of home blood pressure measurement rate | Changes of home blood pressure measurement rate in study population after 3 year of follow up from baseline | from baseline to 3 years of follow up | 
| Cardiovascular disease events and target organ damage | Difference of occurrence of cardiovascular disease events and target organ damage between patient who measure and do not measure home blood pressure Composites of cardiovascular disease events: number of participants with first occurrence of non-fatal myocardial infarction, angina pectoris, revascularization of arteries, stroke, transient ischemic attack, atrial fibrillation, heart failure hospitalization, progression to end-stage renal failure or elevation of creatinine more than 2-fold, other undefined cardiovascular events at the discretion of the investigator Target organ damage: left ventricular hypertrophy by electrocardiography, brachial-ankle pulse wave velocity, microalbuminuria from enrollment | during 3 years of follow up from baseline measurement |