Is Video-assisted Thoracoscopic Lobectomy a Clinical Alternative for Surgically Resectable Pathologic N2 NSCLC Patients

Study Overview
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Brief Summary
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The study was designed to compare the safety and effectiveness of vedio-assisted thoracoscopic lobectomy with open lobectomy for patients with surgically resectable pathologic N2 non-small cell lung cancer

Detailed Description
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The is a multi-center retrospective study. Patients with pathologic N2 NSCLC who underwent VATS or open lobectomy between 2014 and 2017 were included into this study. Clinical data on patient demographic, clinical characteristics, treatment and clinical outcomes will be collected to evaluate the safety and effectiveness of video-assisted thoracoscopic lobectomy for pathologic N2 NSCLC.

Official Title
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Vedio-assisted Thoracoscopic Lobectomy vs Open Lobectomy for Patients With Surgically Resectable Pathologic N2 NSCLC

Conditions
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Non-small Cell Lung Cancer

Intervention / Treatment
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* Procedure: VATS lobectomy
* Procedure: Thoracotomy lobectomy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with age > 18 years old; Patients with pathologically diagnosed non-small cell lung cancer; Patients underwent lobectomy by either VATS or thoracotomy between 2014 and 2017; Patients who received lymphadenectomy for all accessible lymph nodes; Patients with N2 lymph nodes (+) after surgeries; Exclusion Criteria: Patients with second primary tumors or multiple primary tumors; Patients who received chest surgeries before hospitalization; Patients with superior pulmonary sulcus tumor

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| VATS lobectomy<br>Pathologic N2 NSCLC patients who received lobectomy by video-assisted thoracoscopic surgery | Procedure: VATS lobectomy<br>* Patients who received lobectomy by video-assisted thoracoscopic surgery<br>|
| Thoracotomy lobectomy<br>Pathologic N2 NSCLC patients who received lobectomy by thoracotomy | Procedure: Thoracotomy lobectomy<br>* Patients who received lobectomy by thoracotomy<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overall survival | Overall survival | 2014-2018 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Duration of hospital stay [Perioperative outcomes] | Duration of hospital stay [Perioperative outcomes] | 2014-2017 | 
| Postoperative 30 and 90 days [Perioperative outcomes] | Postoperative 30 and 90 days [Perioperative outcomes] | 2014-2017 | 
| Drainage time [Perioperative outcomes] | Drainage time [Perioperative outcomes] | 2014-2017 | 
| Intraoperative blood loss [Perioperative outcomes] | Intraoperative blood loss [Perioperative outcomes] | 2014-2017 | 
| Postoperative complications [Perioperative outcomes] | Postoperative complications [Perioperative outcomes] | 2014-2017 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Vedio-assisted thoracoscopic lobectomy, Thoracotomy lobectomy, Real-world evidences;, pN2 NSCLC