Cognitive Behavioral Therapy Plus Drug Treatment for Obsessive Compulsive Disorder

Study Overview
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Brief Summary
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This study will evaluate the effectiveness of two cognitive behavioral therapies (CBTs) in treating obsessive compulsive disorder (OCD) in patients who are taking medication but still have residual symptoms.

Detailed Description
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Participants remain on their current OCD medication and are randomly assigned to receive one of two CBTs: exposure and ritual prevention or stress management therapy. Exposure and ritual prevention involves imaginal and in-vivo exposure and requires that participants refrain from ritualizing. Stress management involves relaxation, assertiveness training, and structured problem-solving. Therapy occurs twice per week for 2 months. Participants are assessed verbally by an independent evaluator and are asked to complete self-rating forms. Patients who respond are followed for up to 1 additional year. Participants continue to take the same medication and the same monthly therapy for the first 6 months of follow-up. During the second 6 months of follow-up, participants discontinue therapy but continue taking the same medication. For information on a related study, please follow this link: http://clinicaltrials.gov/show/NCT00389493

Official Title
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CBT Augmentation for SRI Pharmacotherapy in OCD

Conditions
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Obsessive-Compulsive Disorder

Intervention / Treatment
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* Behavioral: Exposure and Ritual Prevention (Cognitive Behavioral Therapy)
* Behavioral: Stress Management Therapy (Cognitive Behavior Therapy)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Obsessive-Compulsive Disorder (OCD) diagnosis Currently taking a serotonin reuptake inhibitor (SRI, i.e. clomipramine, fluoxetine, fluvoxamine, paroxetine, sertraline, or citalopram) for OCD Exclusion Criteria: Medical or psychiatric conditions that would make participation in the study hazardous Intensive cognitive-behavioral therapy while on an adequate dose and duration of an SRI for OCD

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Exposure and Ritual Prevention<br>Exposure and Ritual Prevention Therapy | Behavioral: Exposure and Ritual Prevention (Cognitive Behavioral Therapy)<br> <br> |
| Active Comparator: Stress Management<br>Stress Management Therapy | Behavioral: Stress Management Therapy (Cognitive Behavior Therapy)<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Obsessive-compulsive symptoms measured at Month 2 |  | 2 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| General functioning measured at Month 2 |  | 2 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cognitive Behavioral Therapy