Depression and Facial Identity Recognition Abilities in Patients With Multiple Sclerosis

Study Overview
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Brief Summary
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Cognitive and emotional disorders are often encountered in multiple sclerosis (MS) cases: depressive and bipolar disorders are twice as frequent as in general population. Cognitive disorders, (particularly attention and dysexecutive disorders), appear in early stages of the disease's evolution, in cases of lightly or moderately disabled patients, with a recent evolution, with a minor form of the disease, even in Clinically Isolated Syndromes (CIS). Emotional disturbances are essentially linked to mood disorders of depression-type. Last ten years, emotional processing in multiple sclerosis cases was investigated in various trials, especially regarding the recognition of facial and emotional expressions. These studies reported data, supporting an impairment of the perception of emotion, particularly those with negative valence. The objective of this study is to investigate the link between recognition of facial and emotional expressions and depression in multiple sclerosis cases.

Official Title
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Depression and Reconnaissance of Emotions in Multiple Sclerosis Patients

Conditions
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Multiple Sclerosis, Depression

Intervention / Treatment
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* Other: Neuropsychological and emotional evaluation with monitoring


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Man or Woman between 18 and 65 years old Participant understanding and able to speak French Participant understanding the Participant Informed Sheet and who has signed the Informed Consent Participant with Health Insurance MS Patients : Patient with relapsing remitting multiple sclerosis form Expanded Disability Status Scale (EDSS) < 4 Patient without motor disorders, cerebellar or significant upper limb somatosensory or visual disturbances Control Participants : Participant without global cognitive deterioration Exclusion Criteria: Participant taking part of other biomedical studies involving drug tests Participant with other neurological pathologies, head trauma with loss of consciousness, psychiatric pathologies, serious general affections, alcoholism, perception disorders, dysarthria, disorders preventing oral communication and reading, under prescription of psychotropic drugs Mental or visual incapacity to take part in the study Participant with antecedents of drug or alcohol abuse Allergy to the components of the gel used during the EEG Patients with MRI contraindications : Pacemaker or neurostimulator or Implantable Cardioverter Defibrillator (ICD), Cochlear Implants, ocular or cerebral ferromagnetic foreign body close to the nerve structures, metal prostheses, Uncooperative or agitated patients, Claustrophobic patients, Ventricular peritoneal shunts and neurosurgical valves, Braces MS patient without MRI in the last 4 months Adults under guardianship, under judicial protection, persons deprived of liberty, Pregnant or breast feeding women, MS patient with another MS form than Relapsing-Remitting, MS patient who encountered a relapse in the last 6 weeks, MS patient treated with corticoids in the last month.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Depressive MS patients<br>Neuropsychological and emotional evaluation with monitoring | Other: Neuropsychological and emotional evaluation with monitoring<br>* Recognition tasks of emotional facial expressions with electroencephalogram, electrodermal activity measure and heart rate measure, questionnaires and neuropsychological tests<br>|
| Non depressive MS patients<br>Neuropsychological and emotional evaluation with monitoring | Other: Neuropsychological and emotional evaluation with monitoring<br>* Recognition tasks of emotional facial expressions with electroencephalogram, electrodermal activity measure and heart rate measure, questionnaires and neuropsychological tests<br>|
| Control<br>Neuropsychological and emotional evaluation with monitoring | Other: Neuropsychological and emotional evaluation with monitoring<br>* Recognition tasks of emotional facial expressions with electroencephalogram, electrodermal activity measure and heart rate measure, questionnaires and neuropsychological tests<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of correct answers to recognition tasks of emotional facial expressions (categorization by anger, joy or neutral) |  | first day of enrollement | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between facial identity recognition abilities and physiological index measured by electroencephalography |  | first day of enrollement | 
| Correlation between facial identity recognition abilities and morphological index measured by magnetic resonance imaging |  | first day of enrollement | 
| Correlation between facial identity recognition abilities and cognitive functions evaluated by different tests |  | first day of enrollement |