Effects of Systemic Drugs on Intraocular Pressure

Study Overview
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Brief Summary
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To assess intraocular pressure changes among glaucoma patients on systemic antihypertensive and antihistaminic drugs.

Detailed Description
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Changes in intraocular pressure in glaucomatous patients with narrow angle may elicit attacks of angle closure glaucoma. In this study we aim to assess changes in intraocular pressure (IOP) among glaucomatous patients on systemic antihypertensive and antihistaminic drugs.

Official Title
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Effects of Two Systemic Drugs on Intraocular Pressure in Narrow Angle Glaucoma

Conditions
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Glaucoma, Angle-Closure, Glaucoma Suspect, Glaucoma Secondary to Drugs, Bilateral, Hypertension

Intervention / Treatment
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* Drug: Antihypertensive Agents
* Drug: Antihistaminics


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients with narrow angle glaucoma on systemic antihypertensive and/or antihistaminic drugs. Exclusion Criteria: open angle glaucoma patients confirmed by gonioscopy examination. Cases with dense corneal opacity or iris trauma that may affects gonioscopy examination. cases with secondary glaucoma.

Ages Eligible for Study
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Minimum Age: 35 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Antihypertensive drugs group<br>Changes in IOP among patients on antihypertensive drugs | Drug: Antihypertensive Agents<br>* Patients with narrow angle glaucoma and on systemic antihypertensive drugs.<br>|
| Antihistaminic drugs group<br>Changes in IOP among patients on antihistaminic drugs | Drug: Antihistaminics<br>* Patients with narrow angle glaucoma and on systemic antihistaminic drugs.<br>|
| Antihypertensive and antihistaminic drugs group<br>Changes in IOP among patients on both antihypertensive and antihistaminic drugs | Drug: Antihypertensive Agents<br>* Patients with narrow angle glaucoma and on systemic antihypertensive drugs.<br>Drug: Antihistaminics<br>* Patients with narrow angle glaucoma and on systemic antihistaminic drugs.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in intraocular pressure (IOP) measured by applanation tonometry | Changes in IOP measured by millimeter mercury (mmHg) | Immediately after visual acuity assessment for each eye after topical anesthetic eye drops and again on one and three months visit | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in pupil diameter | Size of pupil measured in millimeters (mm) 7sing autorefractometer | Immediately after slit lamp examination and again on one and three months visit | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Hypertension, Angle closure glaucoma, Antihistaminic, Antihypertensive