Effects of General Anesthesia on Quality of Recovery After Transaxillary Endoscopic Breast Augmentation

Study Overview
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Brief Summary
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Among aesthetic or cosmetic surgeries, breast augmentation was the most frequently performed and the endoscopic transaxillary approach has become the preferred incision for Asian women. As breast augmentation must be performed under general anesthesia accompanied by its effects and potential complications, types of general anesthesia may affect the quality of recovery. Currently, the two most common techniques of general anesthesia are inhalation anesthesia (IH) and total intravenous anesthesia (TIVA). The effects of these types of general anesthesia on the quality of recovery have been investigated for numerous surgical procedures. However, no prior studies have analyzed different types of anesthesia used for performing transaxillary endoscopic breast augmentation. This prospective, parallel, randomized controlled study will evaluate the effects of inhalation anesthesia vs. total intravenous anesthesia on the quality of recovery in patients undergoing transaxillary endoscopic breast augmentation.

Official Title
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Chimay Plastic Surgery Clinic, Taipei

Conditions
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Breast Augmentation, Inhalation Anesthesia, Total Intravenous Anesthesia, Quality of Recovery

Intervention / Treatment
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* Drug: Desflurane
* Drug: Propofol


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients are appropriate for undergoing transaxillary endoscopic breast augmentation Age between 20-65 years Physical Status I or II as defined by the American Society of Anesthesiologists (ASA) Physical Status Classification System Exclusion Criteria: Having difficulty reading or hearing Diagnosed with addictive disorder Diagnosed with psychiatric disorder Physical Status III-VI as defined by the ASA Physical Status Classification System Presence of acute infection or inflammatory condition (e.g., fever).

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: IH group<br>Inhalation anesthesia will be given during transaxillary endoscopic breast augmentation. | Drug: Desflurane<br>* Anesthesia is maintained by desflurane in an oxygen air mixture of 60/40%. If inadequate depth of anesthesia is observed, the end-expiratory concentration of desflurane would be increased.<br>|
| Active Comparator: TIVA group<br>Total intravenous anesthesia will be given during transaxillary endoscopic breast augmentation. | Drug: Propofol<br>* Anesthesia is maintained by propofol 100-200 μg/kg/min. If inadequate depth of anesthesia is observed, the rate of propofol infusion would be increased.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quality of recovery, postoperative day one | Quality of recovery is assessed by the 15-item Quality of Recovery (QoR-15) questionnaire. The total score of the 15-item QoR ranges from 0 to 150, and a higher score indicates a better outcome. | On the 1st postoperative day | 
| Quality of recovery, postoperative day two | Quality of recovery is assessed by the 15-item Quality of Recovery (QoR-15) questionnaire. The total score of the 15-item QoR ranges from 0 to 150, and a higher score indicates a better outcome. | On the 2nd postoperative day |