A Cross-sectional and Cohort Study of COVID-19 Patients With Post - Discharge Dysfunction

Study Overview
=================
Brief Summary
-----------------
Post-discharge rehabilitation regimens for covid-19 patients have not been supported by high-quality evidence-based medical evidence.The first part of this study is a cross-sectional study.The contents of the study were the factors related to the dysfunction of COVID - 19 patients after discharge from the hospital in Wuhan.The second part of this study is a cohort study.To observe the functional changes of COVID-19 patients after discharge in hospital rehabilitation, home rehabilitation and no rehabilitation, in order to propose a more safe and effective rehabilitation program.

Official Title
-----------------
A Cross-sectional and Cohort Study of COVID-19 Patients With Post - Discharge Dysfunction

Conditions
-----------------
Covid19, Respiratory Rehabilitation, Cross-sectional Study, Cohort Study

Intervention / Treatment
-----------------
* Combination Product: Respiratory rehabilitation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients with definite diagnosis of COVID-19 normal or severe patients who entered the isolation point <3 days after discharge 18-80 years old agree to join the queue Exclusion Criteria: body temperature >38°C heart rate >120 times/min or <40 times/min, systolic blood pressure <90mmHg or >180mmHg, respiratory rate >25 times/min in calm state.Or above vital signs fluctuate significantly. continuous oxygen therapy is required. patients with myocarditis, pulmonary hypertension, congestive heart failure, fresh venous thromboembolic diseases, unstable fractures and other inappropriate exercise patients with consciousness disorders, severe sequelae of cerebral infarction, cognitive dysfunction, mental disorders, severe balance disorders, and severe bone and joint diseases, which affect evaluation and treatment other conditions that cannot be cooperated with rehabilitation treatment

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Rehabilitation guidance group<br>1 to 2 times of rehabilitation instruction according to the rehabilitation instruction program, either online or in person.According to the rehabilitation instruction, the patient performed self-rehabilitation exercises in the isolation point. | |
| Systematic rehabilitation treatment<br>According to the systematic rehabilitation treatment program, the rehabilitation therapist entered the home for one-to-one rehabilitation treatment, once a day, for a total of 10 days. | Combination Product: Respiratory rehabilitation<br>* Health education and energy saving techniques, chest activity training, local lung dilation techniques, breathing training, airway clearance training, aerobic exercise, resistance training<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Symptoms and signs | To take a history and physical examination | Ten days | 
| Respiratory function | To take a physical examination and mMRC | Ten days | 
| The body function | To take a MMT, 6-min walking test and Borg Index | Ten days | 
| ADL | To take a modified Barthel index | Ten days |