Everolimus in Treating Patients With Relapsed or Refractory Multiple Myeloma

Study Overview
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Brief Summary
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RATIONALE: Everolimus may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the cancer. PURPOSE: This phase II trial is studying how well everolimus works in treating patients with relapsed or refractory multiple myeloma.

Detailed Description
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OBJECTIVES: Primary To assess the response rate in patients with relapsed or refractory multiple myeloma treated with everolimus. Secondary To evaluate the toxicity of everolimus in patients with multiple myeloma. To study the tumor cells and blood from patients entering this trial for laboratory correlates. OUTLINE: Patients receive oral everolimus once daily on days 1-28. Treatment repeats every 4 weeks for up to 12 courses in the absence of disease progression or unacceptable toxicity. Patients undergo bone marrow aspirate, biopsy, and blood sample collections periodically. Samples are assessed for the following: cyclin D1, phospho-AKT, phospho-p70 S6 kinase, and phospho-S6 by western blot; checkpoint regulators PTEN, p53, pRB, and p27 by immunoblotting; p53, Rb, p16, PTEN, p27, and cyclin D1 by DNA analysis; caspases 3 and 9 by immunoblotting and Annexin/PI by flow cytometry; unknown molecular markers by protein profiling; and microvessel density. After completion of study treatment, patients are followed every 3-6 months for up to 2 years.

Official Title
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Phase II Trial of RAD001 in Relapsed/Refractory Multiple Myeloma

Conditions
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Multiple Myeloma and Plasma Cell Neoplasm

Intervention / Treatment
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* Drug: everolimus
* Genetic: DNA analysis
* Genetic: protein analysis
* Genetic: western blotting
* Other: flow cytometry
* Other: laboratory biomarker analysis
* Procedure: biopsy


Participation Criteria
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Eligibility Criteria
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DISEASE CHARACTERISTICS: Diagnosis of multiple myeloma, meeting 1 of the following criteria: Monoclonal protein in the serum of ≥ 1 g/dL Monoclonal light chain in the urine protein electrophoresis of ≥ 200 mg/24 hours Measurable light chains by free light chain assay of ≥ 10 mg/dL Measurable plasmacytoma Must have received prior therapy and have relapsed or refractory disease PATIENT CHARACTERISTICS: ECOG performance status 0-2 Life expectancy ≥ 12 weeks ANC ≥ 1,000/mm³ Platelet count ≥ 75,000/mm³ Hemoglobin ≥ 8.0 g/dL Total bilirubin ≤ 2.0 mg/dL (if total bilirubin is elevated, direct bilirubin must be normal) AST ≤ 3 times upper limit of normal (ULN) Creatinine ≤ 1.5 times ULN Calcium < 11 mg/dL No uncontrolled infection Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception No HIV positivity PRIOR CONCURRENT THERAPY: See Disease Characteristics At least 3 weeks since prior cytotoxic chemotherapy At least 2 weeks since prior biologic therapy or radiotherapy At least 2 weeks since prior corticosteroids Concurrent chronic corticosteroids allowed for treatment of disorders other than myeloma No other concurrent chemotherapy, immunotherapy, radiotherapy, or any ancillary therapy considered investigational

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: everolimus|nan|
|Genetic: DNA analysis|nan|
|Genetic: protein analysis|nan|
|Genetic: western blotting|nan|
|Other: flow cytometry|nan|
|Other: laboratory biomarker analysis|nan|
|Procedure: biopsy|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Confirmed response (complete response, very good partial response, partial response, or minimal response) of serum and urine monoclonal protein |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Toxicity |  |  | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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refractory multiple myeloma