Acute Rehabilitation in Patients With COVID-19 Pneumonia

Study Overview
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Brief Summary
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COVID-19 can have different clinical manifestations including myalgia, arthralgia, neurological, cardiac, psychological and other manifestations.These patients are at greater risk of developing consequences of prolonged bed rest. Therefore physical medicine and rehabilitation could have an important role in the multidisciplinary treatment of these issues. Early respiratory and neuromuscular rehabilitation is necessary to improve functional physical limitations, performance, muscle strength, endurance as well as cognitive and emotional domains. Some studies proposed that rehabilitation protocols in the inpatient setting include early mobilisation, strength and endurance training with the aim of reducing weakness and dependency. This Study aimed to detect the effects of rehabilitation in patients with Covid-19 who were admitted in temporary Covid hospital in Serbia. Furthermore, to emphasize the importance of functional assessment of the patients, in identifying their problems and selections of priorities in planning the best therapeutic protocol.

Official Title
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Acute Rehabilitation in Patients With COVID-19 Pneumonia a Single Center Experience From a Developing Country

Conditions
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COVID-19, Rehabilitation, Physical Medicine

Intervention / Treatment
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* Procedure: Acute rehabilitation program


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Positive pharyngeal or nasal swab for SARS CoV-2, 3) SP O2> 94% on admission, 4) body temperature under 37.5 5) Clinical stability defined by ability to perform bedside active mobilization without a reduction of oxygen saturation (SpO2) below 92%; Exclusion Criteria: 1) SP o2 < 94% on admission, 2) Moderate and severe heart failure (grade III and IV, NY heart Association), 3) Paresis or plegia as a result of CVI or neurodegenerative disease, 4) Impaired cognitive status.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 95 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Severity of COVID-19 infection<br>Based on the severity of Covid-19 infection patients were divided into 2 groups: First group (MMG) mild to moderate group and second group (SSG) stable severe group. | Procedure: Acute rehabilitation program<br>* Patients included in the study started the rehabilitation program when they were hemodynamic stable, when it was determined that it was safe for patients. Until discharge from the hospital, a re-evaluation of neuromuscular and respiratory function was performed.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| functional outcome of activity of daily living | Bartel index (BI) | up to three weeks | 
| functional outcome of cardiovascular and respiratory system | six minute walk test (6MWT) | up to three weeks | 
| functional outcome for assesing dyspnea | Borg scale for dyspnea, | up to three weeks | 
| functional outcome of mobility | Time Up and Go test (TUG) | up to three weeks | 
| functional outcome of lower limbs strength | Sit To Stand test (STS) | up to three weeks | 
| functional outcome of static balance | One Leg Stance Test (OLST) | up to three weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Acute rehabilitation, COVID-19 pneumonia