Progesterone Levels and Pregnancy Results

Study Overview
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Brief Summary
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The aim of this study is to evaluate the amniotic fluid and serum progesterone level and pregnancy outcome

Detailed Description
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Studies have investigated the relationship between maternal serum progesterone level and low birth weight baby birth, hypertensive disorders of pregnancy, and early pregnancy bleeding. In some cases, patients are supported by oral or vaginal progesterone treatments during pregnancy. We also measure the relationship between maternal serum progesterone by measuring the level of amnion progesterone; We aimed to analyze the effects on pregnancy outcomes by observing preterm birth, premature rupture of membranes, low birth weight, baby gender, maternal problems that may occur during pregnancy, fetal problems.

Official Title
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The Effect of Maternal Serum and Amniotic Fluid Progesterone Levels on Pregnancy Results

Conditions
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Pregnancy Complications, Pregnancy Preterm, Pregnancy Loss

Intervention / Treatment
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* Diagnostic Test: amniocentesis


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Singleton pregnancy Women who did not receive progesterone treatment during pregnancy Exclusion Criteria: Women who receive progesterone treatment during pregnancy multiple pregnancies Diagnosed hypertension, diabetes mellitus, kidney disease, heart disease, liver disease

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>amniotic fluid progesterone (this group will be evaluated by the amniotic fluid which was received via amniocentesis). This group consisted of pregnant women who had high risk in the antenal test and give consent to perform amniocentesis. Notwithstanding, amniocentesis detects chromosome abnormalities, neural tube defects, and genetic disorders for the fetuses. İn a routine amniocentesis, 1-2 ml amniotic fluid which was taken in the first place was discarded in order to prevent maternal contamination. Then 15-20 ml amniotic fluid was taken from all of the patients to diagnose genetic disorders of the fetuses. İn this study we evaluate the amniotic fluid progesterone in this 1-2 ml amniotic fluid which was discarded and throw away. Therefore, we are not performing an extra invasive procedure for pregnant women | Diagnostic Test: amniocentesis<br>* amniocentesis will be performed to the pregnant women at 16-20 weeks who had a high-risk antenatal test. Furthermore, these women also give a blood sample (at 16-20 weeks) to compare the amniotic fluid and serum progesterone levels in association with pregnancy outcomes. We perform amniocentesis to evaluate genetic disorders in pregnant women who had his risk in the antenal test.<br>|
| 2<br>serum progesterone (this group consisted of the pregnant women who have amniocentesis procedure and blood samples were taken in the same procedure ) | Diagnostic Test: amniocentesis<br>* amniocentesis will be performed to the pregnant women at 16-20 weeks who had a high-risk antenatal test. Furthermore, these women also give a blood sample (at 16-20 weeks) to compare the amniotic fluid and serum progesterone levels in association with pregnancy outcomes. We perform amniocentesis to evaluate genetic disorders in pregnant women who had his risk in the antenal test.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| pregnancy outcome | premature membran rupture Web sonuçları Premature Rupture of Membranes | starting from 16 weeks, ending at the delivery of the baby | 
| pregnancy outcome | pregnancy loss | starting from 16 weeks, ending at the delivery of the baby | 
| pregnancy outcome | preeclampsia | starting from 16 weeks, ending at the delivery of the baby | 
| pregnancy outcome | gestational diabetes | starting from 16 weeks, ending at the delivery of the baby | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| fetal outcomes | low birth weight | starting from 16 weeks, ending at the delivery of the baby | 
| fetal outcomes | preterm labor | starting from 16 weeks, ending at the delivery of the baby | 
| fetal outcomes | fetal gender | starting from 16 weeks, ending at the delivery of the baby |