The Quantitative Changes in Palatal Donor Sites Thickness After Free Gingival Graft Harvesting

Study Overview
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Brief Summary
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Our primary objective in this clinical intervention study, therefore, was to explored the effect of residual tissue thickness on the palatal mucosa healing from baseline to 1, 3 and 6 months after free gingival graft harvesting in order to determine as soon as possible to re-harvest gingival graft from same site.

Detailed Description
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Forty individuals (19 males and 21 females; age range: 18-35 years) were enrolled in the study. Based on the remaining tissue at donor site after free gingival graft harvesting, individuals were divided into two groups: 1.0-1.9 millimeter (mm) remaining tissue at donor site after harvesting (n = 20), 2-2.9 mm remaining tissue at donor site after harvesting. Tissue filling in defect area from three points (mesial, central and distal) was measured at various time-points (baseline, post-operative 1, 3, 6 months).

Official Title
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The Quantitative Changes in Palatal Donor Sites Thickness After Free Gingival Graft Harvesting

Conditions
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Healthy, Gingival Recession

Intervention / Treatment
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* Other: Less than 2 mm remaining palatal tissue thickness
* Other: 2 mm or more remaining palatal tissue thickness


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All individuals received oral hygiene instructions and full-mouth scaling was performed. -They were instructed to perform a non-traumatic brushing technique (Roll) using an ultra-soft toothbrush Individuals were re-evaluated at 8 weeks after initial therapy, and only full mounth plaque score and full mounth bleeding score <15% were enrolled to the surgical procedure mucogingival defects which for soft tissue graft application were indicated For Less than 2 mm group, between 2.5 and 3.4 mm palatal thickness at each measurement points before graft harvesting For 2 mm or more group, between 3.5 and 4.4 mm palatal thickness at each measurement points before graft harvesting. Exclusion Criteria: periapical or palatal pathologies, absence teeth from canine to first molar, excessive forces including mechanical forces from orthodontics and occlusion, systemic diseases that would contraindicate for periodontal surgery or interfere with tissue healing, chronic high-dose steroid therapy, radiation or immunosuppressive therapy, pregnancy, lactation, smoking, or allergy or sensitivity to any drug Study participants had no history of drug therapy known to interfere with healing and to cause gingival enlargement Individuals who had complication such as bleeding, necrosis and delay healing during or after surgery were excluded from the study.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Less than 2 mm<br>Palatal mucosa thickness was measured from baseline to 1, 3 and 6 months after graft harvesting Intervention: Less than 2 mm remaining palatal tissue thickness | Other: Less than 2 mm remaining palatal tissue thickness<br>* The greater palatine and incisive nerves were blocked with 2% lidocaine, 1:100,000 epinephrine injection. After preparation of the recipient bed, free gingival graft was harvested using a handle with knife at palatal donor side with acrylic stent guidance.<br>|
| Active Comparator: 2 mm or more<br>Palatal mucosa thickness was measured from baseline to 1, 3 and 6 months after graft harvesting Intervention: 2 mm or more remaining palatal tissue thickness | Other: 2 mm or more remaining palatal tissue thickness<br>* The greater palatine and incisive nerves were blocked with 2% lidocaine, 1:100,000 epinephrine injection. After preparation of the recipient bed, free gingival graft was harvested using a handle with knife at palatal donor side with acrylic stent guidance.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in remaining palatal tissue thickness |  | From baseline remaining palatal tissue thickness to post-operative 1, 3, 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Free gingival graft, Palatal donor site healing