Relationship Between Cardiovascular Disease in Asthma and Eosinophil Subtypes and Biomarkers of Bronchial Remodeling.

Study Overview
=================
Brief Summary
-----------------
To know the clinical and inflammatory characteristics of patients with asthma and associated cardiovascular disease.

Detailed Description
-----------------
Recent studies have shown that asthma could be a risk factor for cardiovascular disease, especially in the female and late-onset subgroups. The two entities share several risk factors, such as chronic inflammation and bronchial remodeling. Eosinophilia, characteristic of asthma, has also been described as a predictor of cardiovascular mortality. The aim of this study is to determine the clinical and inflammatory characteristics of patients with asthma and associated cardiovascular disease, as well as their relationship with eosinophil subtypes, biomarkers of chronic inflammation and bronchial remodeling.

Official Title
-----------------
Relationship Between Cardiovascular Disease in Asthma and Eosinophil Subtypes and Biomarkers of Bronchial Remodeling.

Conditions
-----------------
Asthma, Cardiovascular Diseases

Intervention / Treatment
-----------------
* Other: Asthma and cardiovascular disease


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Previous diagnosis of asthma Signed informed consent Exclusion Criteria: Age under 18 years old Age over 99 years old Pneumological diseases other than asthma Active oncological diseases or with end of treatment <5 years Autoimmune or systemic inflammatory diseases

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 99 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| With cardiovascular disease<br>Asthma patients with cardiovascular disease | Other: Asthma and cardiovascular disease<br>* To know the clinical and inflammatory characteristics of patients with asthma and associated cardiovascular disease, as well as their relationship with eosinophil subtypes, biomarkers of chronic inflammation and bronchial remodeling.<br>|
| Without cardiovascular disease<br>Asthma patients without cardiovascular disease | Other: Asthma and cardiovascular disease<br>* To know the clinical and inflammatory characteristics of patients with asthma and associated cardiovascular disease, as well as their relationship with eosinophil subtypes, biomarkers of chronic inflammation and bronchial remodeling.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical characteristics of patients with asthma | Spirometry with bronchodilator testing | 1 year | 
| Associated cardiovascular disease type | Cardiac infarction, stroke or peripheral artery disease | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Eosinophil subtypes | Eosinophil subtypes of patients with asthma and cardiovascular disease | 1 year | 
| Biomarkers of chronic inflammation | Transforming growth factor-β, interleukin-5, interleukin-13, interleukin-25 and interleukin-3 | 1 year | 
| Bronchial remodeling | Bronchial remodeling of patients with asthma and cardiovascular disease measured by analysis of images obtained by thoracic CT scanning | 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Asthma, Cardiovascular Diseases, Chronic inflammation, Bronchial remodeling, Eosinophilia