the Effect of Probiotics on Aging Population

Study Overview
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Brief Summary
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This study intends to recruit aging population (over 65 years old). The investigators use 16 SrDNA sequencing technology, genome sequencing technology, metabonomics, random forest forecast model, analysing and selecting specific age-related intestinal flora. The investigators select probiotics slowing down senility. Then the investigators use the probiotics to intervene in the aging population. Finally the investigators observe whether the probiotics can delay aging.

Detailed Description
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This project plans to recruit the aging population (aged over 65 years old) and comprehensively analyze the public database and self-sequencing clinical big data by using 16 srDNA sequencing technology, metagenomic sequencing technology, metabonomics methods and Random Forest (R) prediction model to judge the key bacterial communities and related functional pathways related to aging.Based on the analysis results, the probiotics with the potential to alleviate aging were selected for intervention evaluation of aging population. This topic aims to explore the change process of intestinal flora structure and composition related to aging process.Identify the key intestinal bacteria genera/species/strains associated with aging, and target the pathway and metabolic characteristic spectrum of the key bacterial communities associated with aging;And select and breed specific intestinal bacterial strains related to aging.The aim is to reduce the age-related metabolic abnormalities and chronic inflammation, reduce medical treatment, rationally allocate medical resources, reduce medical costs and improve the quality of life.

Official Title
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Study for the Effect of Probiotics on Aging Population

Conditions
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Debility

Intervention / Treatment
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* Dietary Supplement: Bifidobacterium longum
* Dietary Supplement: A placebo made of starch


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Over 65 years old Frail scale score above 3 points Exclusion Criteria: Severe impairment of liver and kidney function The tumor is advanced and life expectancy is less than 2 years Severe cognitive impairment and inability to cooperate Unable to give informed consent Have participated in other study before

Ages Eligible for Study
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Minimum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: One group served as a control group, while the other three groups are treated with different strains of bifidobacterium longum
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: the placebo group<br>A placebo made of starch | Dietary Supplement: A placebo made of starch<br>* placebo<br>|
| Experimental: Bifidobacterium longum group 1<br>Bifidobacterium longum 274 | Dietary Supplement: Bifidobacterium longum<br>* types of intestinal flora<br>|
| Experimental: Bifidobacterium longum group 2<br>Bifidobacterium longum 4-1 | Dietary Supplement: Bifidobacterium longum<br>* types of intestinal flora<br>|
| Experimental: Bifidobacterium longum group 3<br>Bifidobacterium longum gs | Dietary Supplement: Bifidobacterium longum<br>* types of intestinal flora<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Points of probiotics intervention in aging population | The score of Frail scale 0 points is defined as normal.And 1 to 3 points is defined as the early age of debility.Three points or more is defined as debility.The score is lower than before, meaning probiotic intervention can alleviate debility. | one year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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intestinal flora