Intracranial Pressure During Migraine

Study Overview
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Brief Summary
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An increase in intracranial pressure (ICP) during migraine attacks is possible and could contribute to pain initiation and maintenance. From now on, it was not possible to measure ICP in a non-invasive way. The development of a new tool allows non-invasive self-measures of ICP variations. Thus, it is possible for the first time to look for such ICP variations during migraine attacks and to conclude if this mechanism is implied in the pathophysiology of migraine.

Detailed Description
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Womens presenting with regular menstrual migraine treated with triptans will be included in the study. Self-measure of ICP will be performed outside and during menstrual migraine attacks. The potential variations will be compared to the measures done on matched healthy women outside and during menses.

Official Title
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Measure of Intracranial Pressure Variations During Migraine Attacks

Conditions
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Menstrual Migraine

Intervention / Treatment
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* Other: Intracranial pressure variations


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 18 to 50 non menopausal women Menstrual migraine Using a triptan as usual treatment to relieve attacks Usual triptan efficacy although recurrence is possible Exclusion Criteria: Disease of the ear Intracranial hypertension Chronic daily headache Use of topiramate or acetazolamide Triptans used more than 10 days/month Analgesic drug used more than 15 days/month Uncontrolled high blood pressure BMI >30 Ongoing allergic rhinitis or flu

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Women with menstrual migraine<br>Womens presenting with regular menstrual migraine treated with triptans will be included in the study. | Other: Intracranial pressure variations<br>* Self-measure of ICP will be performed outside and during menstrual migraine attacks.<br>|
| Matched control<br>The potential variations will be compared to the measures done on matched healthy women outside and during menses. | Other: Intracranial pressure variations<br>* Self-measure of ICP will be performed outside and during menstrual migraine attacks.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Intracranial pressure variations | Measured during menstrual migraine attacks compared to ICP in non-migraine days and in matched healthy women | during menstrual migraine attacks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Relationships between ICP variations and clinical parameters | Age, BMI, pain intensity, pulsating pain, allodynia, nausea, photophobia, phonophobia, dizziness, tinnitus | during menstrual migraine attacks | 
| Relationships between ICP variations and pain relief |  | during menstrual migraine attacks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Migraine, Intracranial pressure, Headache