Tractography and Diffusion Tensor Imaging of the Human Spinal Cord in Healthy Subjects : Anatomical Atlas

Study Overview
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Brief Summary
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Today, Spinal cord pathologies, whether are tumoral, vascular, traumatic, malformative, inflammatory, or degenerative still constitute a major medico-surgical challenge due to the particular anatomy of the spinal cord. Indeed, the spinal fibers (whether they have a sensory or motor function) are all condensed in an extremely small volume. To date, there is no reliable technique to know the precise position of the spinal tracts specifically involved in the sensory and motor functions of the upper and lower limbs. The purpose of this study is to evaluate the feasibility for differentiating spinal tracts by tractography from a cerebral Diffusion tensor imaging (DTI) Magnetic Resonance Imaging (MRI) sequence (associated with an anatomical sequence) by performing a stitching process with spinal cord DTI MRI sequence, in healthy subjects. The criterion of differentiation of the tracts will be assessed by highlighting already known cerebral tracts (cortico-spinal fibers, spinothalamic, posterior cord) and which will be monitored at the spinal level.

Official Title
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Tractography and Diffusion Tensor Imaging of the Human Spinal Cord in Healthy Subjects : Anatomical Atlas

Conditions
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Healthy Volunteer

Intervention / Treatment
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* Procedure: Spinal cord Tractography in order to differentiate spinal tracts.


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patient> 18 years old Healthy volunteer Social insured in France Patient who signed the informed consent of the study Exclusion Criteria: Medical or surgical history of disease that may affect the central nervous system, or the spine History of spine or spinal cord trauma. Spinal osteoarthritis which can lead to a medullary hyper signal. Contraindication to MRI: claustrophobia, pace-maker, defibrillator, metallic foreign bodies, etc. Subjects benefiting from legal protection (curatorship, guardianship or safeguard of justice). Pregnant and / or breastfeeding woman.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Spinal cord Tractography<br>Healthy volunteer having the tractography exam | Procedure: Spinal cord Tractography in order to differentiate spinal tracts.<br>* Spinal cord tractography using DTI MRI sequences of the brain and spinal cord, in order to differentiate tracts at the spinal cord level; and by performing a stitching process between Brain and Spinal cord DTI sequences.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Spinal tracts differentiation and identification | Percentage of complete tracts identified among healthy volunteer | date of Tractography procedure (DTI MRI) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Spinal cord Tracts Atlas | Elaboration of a tracts classification using a algorithm based on the type, the volume and the fraction of anisotropy and mean diffusivity of each tract | 12 months (end of recruitment and exams) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Tractography, DTI, MRI, spinal cord