Influence of Meal Skipping on Macronutrient Oxidation and Glucose Metabolism Under Isocaloric Conditions

Study Overview
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Brief Summary
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Aim of the study is to investigate the impact of meal skipping (breakfast or dinner skipping) on the regulation of glucose metabolism and macronutrient balance (protein/fat/carbohydrate intake vs. -oxidation). An isoenergetic diet with 3 conventional meals (breakfast, lunch, dinner) serves as a control.

Detailed Description
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The duration of the study is 7 days including 3 days with controlled diet and 4 days (including 5 nights) in a metabolic chamber at the Institute of Nutritional Medicine at the University of Hohenheim. The study phase in the metabolic chamber consists of (i) 1 day with 3 meals/day = baseline day, (ii) 1 day with breakfast skipping, (iii) 1 day with dinner skipping, (iv) 1 washout day where the subjects leave the chamber between 7 a.m. until 7 p.m.. Beginning on the 3rd study day macronutrient and energy intake as well as the fasting periods are kept constant. To achieve comparable conditions the washout day is setted before the baseline day.

Official Title
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Influence of Meal Skipping on Macronutrient Oxidation and Glucose Metabolism Under Isocaloric Conditions

Conditions
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Healthy

Intervention / Treatment
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* Behavioral: Breakfast skipping
* Behavioral: Dinner skipping


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: healthy not obese (BMI<30) Exclusion Criteria: food allergy smoking alternative nutrition habits chronic disease regular medication intake claustrophobia

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Breakfast Skipping<br>Effect of breakfast skipping on metabolism | Behavioral: Breakfast skipping<br>* 18h fasting period in the morning<br>|
| Experimental: Dinner Skipping<br>Effect of dinner skipping on metabolism | Behavioral: Dinner skipping<br>* 18h fasting period in the evening<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Regulation of glucose metabolism (substrate oxidation and insulin sensitivity) |  | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Actigraphy-assessed sleep quality |  | 1 day | 
| cardio vascular risk (lipid profile, arterial stiffness, autonomic function) |  | 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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meal skipping, isocaloric diet, macronutrient oxidation, glucose homeostasis, arterial stiffness