Bronchodilator Test in Mechanical Ventilated Chronic Obstructive Pulmonary Disease Patients

Study Overview
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Brief Summary
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Investigators developed a test to assess the bronchodilator effects in mechanically ventilated chronic obstructive pulmonary disease patients by comparing the change of airway resistance. No matter whether patients respond to bronchodilator or not, they are randomized assigned to bronchodilator 3-4 times per day group and no bronchodilator group. Then investigators could objectively decide whether individual patients need or benefit from bronchodilator administration.

Detailed Description
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Bronchodilator is commonly used in mechanical ventilated chronic obstructive pulmonary disease patients. It is assumed that patient's response to bronchodilator is the same during acute exacerbation or when stable whether on mechanical ventilation or not. Decision to treat is often independent of response and the patient's response to the medicine is not precisely evaluated. Investigators developed a test to assess the bronchodilator effects in mechanically ventilated chronic obstructive pulmonary disease patients by comparing the change of airway resistance. No matter whether patients respond to bronchodilator or not, they are randomized assigned to bronchodilator 3-4 times per day group and no bronchodilator group. Then investigators could objectively decide whether individual patients need or benefit from bronchodilator administration.

Official Title
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Bronchodilator Test in Mechanical Ventilated Chronic Obstructive Pulmonary Disease Patients, a Randomized Controlled Trial

Conditions
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Chronic Obstructive Pulmonary Disease

Intervention / Treatment
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* Drug: Albuterol


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: should meet all the criteria: Acute exacerbated chronic obstructive pulmonary disease Invasive mechanical ventilation with intubation outside ICU no more than 48 hours Exclusion Criteria: Meet any of the criteria: Asthma Tracheotomy Prolonged Mechanical Ventilation (Have been mechanical ventilated for more than 21 days) Unstable hemodynamic status Severe pneumonia Contraindication for bronchodilator Contraindication for sedation Refusal to participate in study Re-intubation in 48 hours Mental disorder, could not understand and accomplish pulmonary function test

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Bronchodilator<br>Albuterol 3-4 times per day, steroids when necessary. | Drug: Albuterol<br> <br> |
| No Intervention: No drug<br>No drug | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percentage of 12% Decrease in airway resistance |  | 30 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Duration of mechanical ventilation |  | participants will be followed for the duration of ICU stay, an expected average of 28 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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airway resistance, lung compliance, Duration of mechanical ventilation