Predictors of Ovarian Reserve in Infertile Women

Study Overview
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Brief Summary
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Patients will be subjected to: A. Clinical evaluation including history and examination B. Ultrasonographic evaluation of Ovarian Morphometry: Patients will be evaluated in early follicular phase of the menstrual flow (cycle's days 1-3) by TVS scanning; using MINDRAY DP-1100 Plus Digital Machine, 7.5MHz, China, by only one examiner to avoid inter-observer variations. Ovarian images will be procured in the sagittal and coronal planes and the frozen image reflecting the largest ovarian dimensions will be utilized for the measurement of ovarian length, width, and height (cm) as per standard clinical practice. Mean values of both ovaries will be used. Ovarian volume will be calculated from ellipsoid volume formula, {Ovarian volume = Ovarian Width (D1) × Ovarian Length (D2) ×Ovarian Height (D3) × 0 .523} Antral follicle count will be determined for each patient C. Laboratory Evaluation: Blood samples will be collected in the early follicular phase. Samples will be immediately centrifuged and serum saved at -20 degrees for measurement of: Anti Mullerian Hormone (AMH) Follicle Stimulating Hormone (FSH) Estradiol (E2) Using electro-chemiluminescence immunoassay (ELICA)

Detailed Description
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Patients will be subjected to: A. Clinical evaluation including history and examination B. Ultrasonographic evaluation of Ovarian Morphometry: Patients will be evaluated in early follicular phase of the menstrual flow (cycle's days 1-3) by TVS scanning; using MINDRAY DP-1100 Plus Digital Machine, 7.5MHz, China, by only one examiner to avoid inter-observer variations. Ovarian images will be procured in the sagittal and coronal planes and the frozen image reflecting the largest ovarian dimensions will be utilized for the measurement of ovarian length, width, and height (cm) as per standard clinical practice. Mean values of both ovaries will be used. Ovarian volume will be calculated from ellipsoid volume formula, {Ovarian volume = Ovarian Width (D1) × Ovarian Length (D2) ×Ovarian Height (D3) × 0 .523} Antral follicle count will be determined for each patient C. Laboratory Evaluation: Blood samples will be collected in the early follicular phase. Samples will be immediately centrifuged and serum saved at -20 degrees for measurement of: Anti Mullerian Hormone (AMH) Follicle Stimulating Hormone (FSH) Estradiol (E2) Using electro-chemiluminescence immunoassay (ELICA)

Official Title
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Sonographic and Laboratory Predictors of Ovarian Reserve in Infertile Women

Conditions
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Ovarian Reserve

Intervention / Treatment
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* Drug: human menopausal gonadotropin


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: less than 39 years old, normal menstrual cycle with a range of 24 to 35 days normal seum prolactin. normal uterine cavity determined by previous hysterosalpingography or hysteroscopy Exclusion Criteria: smokers endometriosis Women with endometriosis; abnormal endocrine functions such as diabetes mellitus, thyroid disorders, and adrenal abnormalities; general diseases, those with ovarian cysts, or those who have azospermia partners.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 39 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: pregnant<br>women with positive pregnancy test after induction of ovulation and ICSI | Drug: human menopausal gonadotropin<br>* Induction of ovulation followed by ICSI<br>* Other names: menogon;|
| Active Comparator: Not pregnant<br>women with negative pregnancy test after induction of ovulation and ICSI | Drug: human menopausal gonadotropin<br>* Induction of ovulation followed by ICSI<br>* Other names: menogon;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| positive pregnancy test |  | 14 days after embryo transfer | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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predictors, ovarian reserve, infertile women