A Warmer Temperature Decrease Propofol Injection Pain

Study Overview
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Brief Summary
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Propofol injection pain will be surfed by up to 70-80 percentage by the Patients who induced by propofol. Temperature of Operating room was set to a certain range in normal clinical practice, which is 22- 26 centigrade. Warm feeling will make skin vassal dilated and more blood will pass through to bring more heat out of our body. It had been reported that a bigger venous vessels will get less propofol injection pain. The investigators hypothesis that Patients who stayed in a warmer room temperature will surf less injection pain while compare to a normal setting room temperature.

Official Title
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A Warmer Room-temperature at 27-28 Centi-degree Will Decrease Propofol Injection Pain

Conditions
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Injection Site Irritation, Propofol Syndrome, Temperature Change, Body

Intervention / Treatment
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* Behavioral: warmer temperature


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ASA I III, aged 18，scheduled or emergency surgery with general anesthesia. Exclusion Criteria: a history of allergy to propofol, allergy to soybean oil with peripheral blood diseases.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: patients for observation will sent to a warmer operating room,while Patients in controled Group will send to normal setting operating room at about 23 centigrade.
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: warmer temperature<br>To compare the incidence and intensity of pain on injection that is caused by propofol in warm temperature（27℃） versus normal temperature(23℃). | Behavioral: warmer temperature<br>* Patients before general anesthesia induction will send to warmer operation Injection pain was accessed with (Visual analogous scale)VAS.<br>|
| Placebo Comparator: normal temperature<br>The purpose of this study is to compare the incidence and intensity of possible pain on injection as well as patient satisfaction caused by propofol in different room temperature(27 VS 23). | Behavioral: warmer temperature<br>* Patients before general anesthesia induction will send to warmer operation Injection pain was accessed with (Visual analogous scale)VAS.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| intensity of injection pain | intensity of injection pain was reported by patient themselves before loss their awareness. | 3 months | 
| numbers of lidocaine rescues for severe injection pain | when unbearable injection happens,patient could ask for stop and 20mg lidocaine was injected as rescue treatments. | 3 months | 
| incidences of injection pain | Numeric Visual Analog Scale of injection >2 was counted as injection pain happens,the total incidence of injection was compared in two groups. | 3 months |