High-flow Nasal Cannula Oxygen Therapy With the Chest Trauma Patients

Study Overview
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Brief Summary
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This prospective randomized controlled study was conducted in the emergency intensive care units (EICU) of the second affiliated hospital Zhejiang university school of medicine, a large tertiary university hospital in HangZhou, China.The aim of this randomized study was to compare the effectiveness of high-flow nasal cannula with conventional oxygen therapy in ICU patients with blunt thoracic injury.

Detailed Description
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This prospective randomized controlled study was conducted in the emergency intensive care units (EICU) of the second affiliated hospital Zhejiang university school of medicine, a large tertiary university hospital in HangZhou, China.The aim of this randomized study was to compare the effectiveness of high-flow nasal cannula with conventional oxygen therapy in ICU patients with blunt thoracic injury.

Official Title
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High-flow Nasal Cannula Oxygen Therapy With the Chest Trauma Patients

Conditions
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Blunt Thoracic Injury, Lung Ultrasound Score

Intervention / Treatment
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* Device: high-flow nasal cannula
* Device: Conventional oxygen therapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: - The trauma registry was used to identify patients with moderate to severe blunt thoracic injury (abbreviated injury scale (AIS) chest score ≥3) admitted to the ICU Exclusion Criteria: had intubation and used the mechanical ventilation within 2 hours had the emergency surgerys within 2 hours patients can not accessed by transthoracic lung ultrasound because of the sever aerodermectasia or pneumothorax the Glasgow Coma Scale <8

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: conventional oxygen therapy<br>oxygen was delivered by a nasal cannula or nonrebreather mask | Device: Conventional oxygen therapy<br>* Conventional oxygen therapy<br>|
| Active Comparator: High-flow Nasal Cannula Oxygen Therapy<br>High-flow Nasal Cannula Oxygen Therapy | Device: high-flow nasal cannula<br>* high flow of air with supplemental oxygen was delivered by an Optiflow cannula interface using an AIRVO 2 blower humidifier<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| compare the effectiveness of high-flow nasal cannula with conventional oxygen therapy in ICU patients with blunt thoracic injury. | High-flow nasal cannula could reduce the intube rate of patients with blunt thoracic injury,and improve the the lung aeration for patients with thoracic injury | 72 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| number of days in ICU | High-flow nasal cannula could reduce the number of days for the patients treatments in ICU | 7 days |