linjc16/ctgov huggingface dataset:
The Effect of Red Blood Cells Transfusion in Trauma Patients

Study Overview
=================
Brief Summary
-----------------
We will evaluate the effect of red blood cell (RBC) transfusion on fatal and non fatal events according to baseline risk of death in an international cohort of trauma patients (CRASH-2 trial). The following outcomes will be considered: death from all causes, death due to bleeding, death due to multiorgan failure, death due to vascular occlusive events and non vascular occlusive events. Non fatal outcomes include: myocardial infarction, stroke, deep vein thrombosis and pulmonary embolism.

Detailed Description
-----------------
Aims: Primary objective: Evaluate the effect of RBC transfusion on all cause mortality according to baseline risk of death due to bleeding. Secondary objectives: Evaluate the effect of RBC transfusion on specific causes of death. Evaluate the effect of RBC transfusion on non fatal vascular occlusive events. Sample: Patients from the Clinical Randomisation of an Antiﬁbrinolytic in Signiﬁcant Haemorrhage (CRASH-2) trial. The trial included 20,127 trauma patients with, or at risk of, significant bleeding, within 8 hours of injury, and was undertaken in 274 hospitals in 40 countries. Outcomes: Death from all causes, death due to bleeding, death due to multiorgan failure, death due to vascular occlusive events and non vascular occlusive events. Vascular occlusive events include: myocardial infarction, stroke, deep vein thrombosis and pulmonary embolism. All events were measured at 28 days or hospital discharge Interventions and comparisons: We will compare the effect of red cells transfusion versus no red cells transfusion. We will also evaluate the effect of the number of units of red cells transfusion. Methods: We will stratify patients according to baseline risk of death from all causes into four strata (<6%, 6%-20%, 21%-50% and >50%). We will then evaluate the effect of RBC transfusion according to baseline risk on fatal and non fatal outcomes. Formal statistical test to detect heterogeneity will be conducted analyzing baseline risk as a continuous variable.

Official Title
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The Effect of Red Blood Cells Transfusion in Trauma Patients: A Risk Stratified Analysis

Conditions
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Trauma

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients eligible for inclusion in the trial were adult trauma patients with ongoing significant haemorrhage, within 8 hours of injury. Exclusion Criteria:

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| mortality |  | 30 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| fatal and non fatal vascular occlusive events |  | 30 days |
Effects of Zinc Supplementation on Anthropometric Factors, Apelin and Inflammatory Markers in Obese Individuals

Study Overview
=================
Brief Summary
-----------------
To study the effects of zinc supplement on anthropometric factors, Apelin and inflammatory markers in obese individuals, 50 obes person who referred to Diet and Nutrition clinic of Shahid Beheshti University of Medical Sciences will be randomly allocated to receive 50 mg zinc capsules or placebos for 15 weeks; both groups will be advised to adherence the investigators' diet . At the first and the end of the intervention,weight, body mass index (BMI), waist circumference, fat mass and lean body mass, concentration of zinc, albumin, hs-CRP, TNF-α and plasma apelin will be assessed and compared between groups.

Official Title
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Effects of Zinc Supplementation on Weight, Body Mass Index (BMI), Waist Circumference, Fat Mass and Lean Mass, Apelin and Inflammatory Markers in Obese Individuals

Conditions
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Obesity

Intervention / Treatment
-----------------
* Dietary Supplement: zinc sulfate
* Other: corn starch


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age of 18 to 45 years Non-smoking Body Mass Index (BMI) more than 30 Exclusion Criteria: Pregnancy, lactation or menopause in women History of liver disease, kidney, thyroid, diabetes and other metabolic diseases Use of drugs interfering with lipid profile, blood-thinning drugs, beta-blockers Patients with immune deficiency Use of zinc, calcium and iron supplement in the last 2 months Use of weight loss medication or special diet Following program to lose weight in recent 2 months Recent surgery

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: zinc sulfate<br>1 zinc sulfate capsule for 15 weeks | Dietary Supplement: zinc sulfate<br>* 1 zinc sulfate capsule for 15 weeks<br>|
| Placebo Comparator: starch<br>1 corn starch capsule for 15 weeks | Other: corn starch<br>* 1 corn starch capsule for 15 weeks<br>* Other names: placebo;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| weight |  | 15 weeks |
Compare the Therapeutic Effect Treated With Tamsulosin and Progesterone After ESWL( Extra Corporeal Shock Wave Lithotripsy) in Urinary Calculus

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to compare the stone clearance rate treated with different drugs after ESWL in urinary calculus,These drugs are often used in urinary calculus,such as progesterone,tamsulosin,propantheline Bromide and nifedipine.In these study the investigators want to investigate different effect of these drugs use to treat urinary calculus after ESWL.

Detailed Description
-----------------
There is 4 groups in these investigation, group1 urinary calculus treated with ESWL only ,group2 urinary calculus treated with ESWL and tamsulosin,group3 urinary calculus treated with ESWL and progesterone,group4 urinary calculus treated with ESWL ,propantheline Bromide and nifedipine.We want to investigate which one is better or not in urinary calculus treated with ESWL .

Official Title
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the Therapeutic Effect Treated With Tamsulosin After ESWL in Urinary Calculus

Conditions
-----------------
Urinary Calculus

Intervention / Treatment
-----------------
* Drug: progesterone,tamsulosin,propantheline Bromide and nifedipine


Participation Criteria
=================
Eligibility Criteria
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Inclusion Criteria: From 18 years old to 68 years old, urinary calculus could be treated by ESWL, the calculus size is from 4-25mm Exclusion Criteria: Less than 18 years old or more than 68 years old, the calculus size is from Less than4 or larger than 25mm

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 68 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: progesterone,tamsulosin,propantheline Bromide and nifedipine<br>different effect of these drugs use to treat urinary calculus after ESWL | Drug: progesterone,tamsulosin,propantheline Bromide and nifedipine<br>* clearance rate of stone<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| different effect of these drugs use to treat urinary calculus after ESWL |  | 2weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
ESWL, urinary calculus, drugs treat
The Effect of Dermatology and Teledermatology Consultations on Length of Hospital Admission, 30 Day Readmission Rate, and Antibiotic Use in Patients Presenting With Cellulitis vs Pseudocellulitis in an Academic Inpatient Setting

Study Overview
=================
Brief Summary
-----------------
The effect of teledermatology on length of hospital admission, length of stay, 30 day readmission rate, and antibiotic use in patients presenting with cellulitis vs pseudocellulitis in an academic emergency department setting.

Official Title
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The Effect of Dermatology and Teledermatology Consultations on Length of Hospital Admission, 30 Day Readmission Rate, and Antibiotic Use in Patients Presenting With Cellulitis vs Pseudocellulitis in an Academic Inpatient Setting

Conditions
-----------------
Cellulitis

Intervention / Treatment
-----------------
* Other: teledermatology consult
* Other: Routine Care


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Over 18 Admission for cellulitis-like symptoms, including but not limited to the following: tenderness, redness, swelling, expansive lesion Exclusion Criteria: pregnant prisoner

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Routine Care vs The use of teledermatology
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Routine Care<br>The first group will be randomized to routine care of receiving or not receiving a dermatology consult in the hospitalized setting based on the clinical decision of the hospitalist. The patients will see the research coordinator who will take images and for a teledermatology assessment, however, these assessments will not be placed in the chart and the treating hospitalist will not know. | Other: Routine Care<br>* The patient will undergo imaging but this report will not be put into the chart.<br>|
| Experimental: Teledermatology INtervention<br>The second arm will be patient randomized to teledermatology intervention. These patients will be imaged by the research coordinator, then the assessment will be placed in the chart for the hospitalist to see although final treatment decisions are still made by the hospitalist. | Other: teledermatology consult<br>* teledermatology consult<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Length of Hospitalization |  | 60 Days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Readmission rate |  | 30 Days | 
| Frequency/Use of antibiotics |  | 30 days |
Gender Dysphoria in Children and Adolescents : Parents' Perspectives

Study Overview
=================
Brief Summary
-----------------
Gender dysphoria is defined as a persistent incongruence between an experienced gender and the assigned sex at birth Transgender and gender nonconforming persons desire to modify their appearance to be consistent with their self-identified gender identities. In non-binary people, contrary to binary transgender persons, self-identified gender identities do not fit the classical pattern male/female. During the last decennium, an increase in the number of young subjects, especially children and adolescents, referred to gender identity centres has been observed. A new nosological entity rapid-onset gender dysphoria in adolescents and young adults has recently been described in the literature, whose etiology has not been well understood. This growing demand of adolescents and young adults observed in the recent years is not well understood.

Official Title
-----------------
Gender Dysphoria in Children and Adolescents : Parents' Perspectives

Conditions
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Gender Dysphoria

Intervention / Treatment
-----------------
* Other: qualitative study


Participation Criteria
=================
Eligibility Criteria
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Inclusion Criteria: be a parent of a child <18 years followed in the endocrinology department of the University Hospital of Nancy for gender dysphoria be in stable couple both parents agree to participate capacity to communicate in French Person who has received complete information on the organization of the research and who agreed to the exploitation of the data Exclusion Criteria: Refusal to participate Inability to be physically, psychologically or linguistically involved in the study

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: qualitative study|qualitative research via guided interview|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| thematic analysis | The recorde material will be coded using descriptive codes. Conceptual notes will be written, through processes of condensation, comparison and abstracting the initial notes. Connections between notes will be noted and synthesized, and emergent themes will be developed. | one year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
children, adolescents, parents
A Prospective Study of a Haptic Device Evaluation of the Acute Abdomen

Study Overview
=================
Brief Summary
-----------------
The study hypothesis is a haptic sensor can aid in the evaluation of the acute abdomen. Investigators from the MSU Department of Surgery in Collaboration with MSU Engineering are assessing the ability of a non invasive, optical device that is placed on a patients abdomen (much like an ultrasound transducer) to evaluate a patient with an acute abdominal presentation. Conditions such as appendicitis, cholecystitis, diverticulitis or small bowel obstruction will be examined with the haptic device. Data will be collected by the device and later compared to the abdominal findings recorded from an examination conducted by the principle investigator who is a surgeon. The surgeon will not have acess to data collected by the haptic sensor and therefore it will have no impact on the decision making process in the care of the patient. The impact on the individual patient will require obtaining a consent to participate in the study, a few minutes to place the device gently on the abdomen and collect the sensor data. There is no direct benefit to the patient by participating in the study. The potential for such a study may be to develop the technology to have a device that non-medical staff can use to collect patient data and transmit that data to a healthcare provider at another location.

Official Title
-----------------
A Prospective Study of a Haptic Device Evaluation of the Acute Abdomen

Conditions
-----------------
Acute Abdomen

Participation Criteria
=================
Eligibility Criteria
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Inclusion Criteria: All patients referred to the MSU Acute Care Surgery service for the evaluation of abdominal pain. Exclusion Criteria: Under 18 years of age

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hardness of the abdominal wall |  | At intial presentation with abdominal pain | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| temperature of the abdominal wall |  | At initial presentation | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Evaluation
Glucose/Insulin Responses:Subjects With Type 2 Diabetes Consuming Diabetes-Specific vs Standard Nutritional Formulas

Study Overview
=================
Brief Summary
-----------------
To measure and compare the glycemic and insulinemic responses of subjects consuming a standard and two diabetes-specific products.

Official Title
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Randomized, Double Blind, Three Way Crossover Comparison of Glucose and Insulin Responses During a Meal Glucose Tolerance Test in Subjects With Type 2 Diabetes Consuming Disease-Specific Versus Standard Nutritional Formula

Conditions
-----------------
Diabetes Mellitus Type 2

Intervention / Treatment
-----------------
* Other: Adult enteral formula


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: signed and dated informed consent 18-75 years of age history of type 2 diabetes males and non-pregnant, non-lactating females Exclusion Criteria: subject uses insulin for glucose control significant cardiovascular event <12 weeks prior to study entry active malignancies history of end stage renal disease history of organ transplant current hepatic disease intervention for HIB takes niacin history of gastroparesis active disease that may interfere with nutrient intake allergy or intolerance to ingredients in the study products

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Quadruple


Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Adult enteral formula|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Adjusted area under the curve (adj-AUC) of glucose response |  | 0-240 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Adjusted peak for glucose and insulin response;peak time for glucose and insulin response; Adj-AUC for insulin response; change in glucose and insulin; subjective gastrointestinal tolerance |  | 0 - 240 minutes |
Health-care Quality in Semi-intensive Care Units

Study Overview
=================
Brief Summary
-----------------
The main aim of this study is to realize a system of continuous evaluation of healthcare quality in semi-intensive care units.

Detailed Description
-----------------
Collecting data of semi-intensive care units' patients and structural data of hospitals, healthcare quality's indicators will be realized. Starting from those indicators of insuccess, specific for different kinds of patients, it will be possibile to evaluate the general level of care in each singular semi-intensive care unit. The study will least for 5 years, but at the end of every year it will be realized a report of analysis to see the results of each unit.

Official Title
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Evaluation and Improvement of the Health-care Quality in Semi-intensive Care Units

Conditions
-----------------
Quality, Semi-intensive Care Unit, Evaluation

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: all patients hospitalised in a semi-intensive care unit Exclusion Criteria: None
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Eligible population<br>All patients admitted in the semi-intensive care units attending the study. Be basing on the average number of patients yearly treated in those units, we expect to have at least 39000 patients during the 5 years of the study. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Outcome for stationary patients with high risk of variability | hospitalization in semi-intensive care unit more than 2 days or transfer to intensive care unit | jan 2021 - dec 2025 | 
| Outcome for low gravity patients, with a low organ's damage | deterioration of the physiopathologic index | jan 2021 - dec 2025 | 
| Outcome for semi-intensive patients | transfer to intensive care unit or hospital mortality | jan 2021 - dec 2025 | 
| Outcome for high risk patients | transfer to intensive care unit or hospital mortality | jan 2021 - dec 2025 |