MRI Parenchymal Enhancement: A New Marker of Breast Cancer Risk

Study Overview
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Brief Summary
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The purpose of this study is to learn about how a woman's health history influences what a normal breast looks like on an MRI. The investigators also want to learn about how the amount of different natural hormones a woman has affects how the breast looks on an MRI. The investigator's hope is that this will help to find women at a high-risk of breast cancer.

Official Title
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Epidemiology of MRI Parenchymal Enhancement: A New Marker of Breast Cancer Risk

Conditions
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Cancer Free Women

Intervention / Treatment
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* Behavioral: questionnaire


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age 21 years or older be a cancer-free pre- or postmenopausal woman have no prior personal history of any cancer (including DCIS, excluding nonmelanoma skin-cancer) able to speak and read English because the questionnaire is only available in English able to provide informed consent Exclusion Criteria: are pregnant at the time of MRI have a prior personal history of any cancer (including DCIS, excluding nonmelanoma skin cancer)

Ages Eligible for Study
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Minimum Age: 21 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| premenopausal women<br>Only women already scheduled for a breast MRI will be included in the study, no additional MRIs will be scheduled for study purposes. | Behavioral: questionnaire<br> <br> * Other names: smoking, contact information/comments.;|
| postmenopausal women<br>Only women already scheduled for a breast MRI will be included in the study, no additional MRIs will be scheduled for study purposes. | Behavioral: questionnaire<br> <br> * Other names: smoking, contact information/comments.;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| breast cancer risk factors and background parenchymal enhancement (BPE). | A comparison of the distribution of breast cancer risk factors in women with low and high levels of BPE. The relationship between risk factors and categories of BPE (minimal/mild/moderate/marked) will be determined using ordinal logistic regression. | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| relationship between BPE and serum hormone levels at the time of MRI | Determine the relationship between serum hormone levels (testosterone, estradiol (E2), estrone (E1), androstenedione (A4) and sex hormone binding globulin (SHBG)) at the time of MRI and degree of BPE in healthy high-risk postmenopausal women. The association between circulating serum hormone levels and BPE will be determined using linear regression. | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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MRI, 12-125, premenopausal women, postmenopausal women, questionnaire