Hand Lateralization by Using EEG Analysis Method in Amputees

Study Overview
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Brief Summary
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Studies on the improvement of body image or body perception have proven their effectiveness in different clinical situations such as pain management and chronic pain treatment. The aim of this study is to evaluate the hand lateralization cognitive task by recording Electroencephalography (EEG) signals from different personal perspectives in amputees. In this study, the paradigm in which personal perspectives are evaluated over the hand lateralization task will be applied to amputees and healthy volunteer participants. Data will be recorded via EEG and Eprime software program.

Detailed Description
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The aim of this study is to evaluate the hand lateralization cognitive task by recording Electroencephalography (EEG) signals from different personal perspectives in amputees. In this study, the paradigm in which personal perspectives are evaluated over the hand lateralization task will be applied to amputees and healthy volunteer participants. It was planned to enroll two groups to the study. One group is named amputees the other one is control. Control group will be matched in terms of age and gender with the amputees group. Before hand lateralization test, participants will be evaluated regarding eligible criterias and EEG paradigm regarding hand lateralization will be performed for each participant. Both groups (Amputees and Control) will complete hand lateralization program for at least 10 days. The test will be sent each day on an online system. Participants' performances will be recorded via online system. Following 10-day period, EEG paradigm regarding hand lateralization will be performed for each participant, again. Before and after comparisons will be analyzed. Data will be recorded via EEG and Eprime software program. EEG-Event Related Oscillation (power spectrum, phase locking) analysis will be performed for each frequency bands: alpha, theta, beta, gamma. Eprime analysis will be performed for the data of reaction time and accuracy rate.

Official Title
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Evaluation of Hand Lateralization Cognitive Task From Different Personal Perspectives by Using EEG Analysis Method in Amputees

Conditions
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Body Image

Intervention / Treatment
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* Behavioral: Hand Lateralization Test


Participation Criteria
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Eligibility Criteria
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Control group: Inclusion Criteria: being between ages 18-65, consenting, with no limitation in mobility or movement disorder, A score of 21 or higher on the Montreal Cognitive Assessment Test Exclusion Criteria: refuse to attend to the study, Having any mental, neurological or musculoskeletal problems, Inability to perform activities that require long-term attention, Inability to detect given commands, Using sedative drugs and/or derivatives Amputee group: Inclusion Criteria: between ages 18-65, using prosthesis, A score of 21 or higher on the Montreal Cognitive Assessment Test Exclusion Criteria: Having phantom pain, Having open wound on stump, Having any discomfort feeling on stump, Having any mental, neurological or musculoskeletal problems, Inability to perform activities that require long-term attention, Inability to detect given commands, Using sedative drugs and/or derivatives

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: One of groups: amputees group<br>We planned to enroll two groups to the study. One group is named amputees the other one is control. Both groups will enroll hand lateralization for at least 10 days. Before and after comparisons will be analyzed. | Behavioral: Hand Lateralization Test<br>* Before hand lateralization test, participants will be evaluated. Both groups (Amputees and Control) will complete hand lateralization test for at least 10 days. The test will be sent each day on an online system. Participants' performances will be recorded via online system. After hand lateralization test, participants will be evaluated.<br>|
| Active Comparator: One of groups: control group<br>Control group will be matched in terms of age and gender with the amputees group. | Behavioral: Hand Lateralization Test<br>* Before hand lateralization test, participants will be evaluated. Both groups (Amputees and Control) will complete hand lateralization test for at least 10 days. The test will be sent each day on an online system. Participants' performances will be recorded via online system. After hand lateralization test, participants will be evaluated.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Electroencephalogram (EEG) frequency bands: alpha, theta, beta, gamma | Changes in power spectrum and phase locking | Before and after the hand lateralization test: 10-14 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Reaction time to decide whether the hand is right or left | E-prime parameter: recorded as milisecond | Before and after the hand lateralization test: 10-14 days | 
| Accuracy proportion of given answers regarding hand lateralization | E-prime parameter: recorded as percentage | Before and after the hand lateralization test: 10-14 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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EEG, mental rotation, hand lateralization, hand recognition, amputees, body schema