Sublingual vs Vaginal Misoprostol for Termination of First Trimesteric Missed Abortion

Study Overview
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Brief Summary
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Efficacy of sublingual versus vaginal misoprostol in termination of first trimester missed abortion

Detailed Description
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study will be made on female patients with first trimester missed abortion confirmed by ultrasound . Participants will be divided into 2 groups one group (A) will receive sublingual Misoprostol and the other group(B) will receive vaginal Misoprostol as a 800 micro grams every 4 hours in both groups up to five doses the aim of the study is to compare efficay of sublingual and vaginal Misoprostol in complete termination of first trimester missed abortion and which route is the best will less side effects.

Official Title
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Sublingual vs Vaginal Misoprostol for Termination of First Trimesteric Missed Abortion

Conditions
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Missed Abortion

Intervention / Treatment
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* Drug: Misoprostol Pill


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Women with an ultrasound diagnosis of missed abortion < 13 weeks gestation without any clinical criteria of Inevitable abortion. Exclusion Criteria: Patients refused the medical treatment. Patients have contraindications of the drug (Misoprostol). Missed abortion associated with any signs of sepsis

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Sublingual Misoprostol for termination of first trimester missed abortion<br>Patients diagnosed as first trimester missed abortion will receive sublingual Misoprostol 800 micrograms every 4 hours up to five doses | Drug: Misoprostol Pill<br>* sublingual versus vaginal Misoprostol in termination of first trimester missed abortion<br>|
| Active Comparator: Vaginal Misoprostol for termination of first trimester missed abortion<br>Patients diagnosed as first trimester missed abortion will receive vaginal Misoprostol 800 micrograms every 4 hours up to five doses | Drug: Misoprostol Pill<br>* sublingual versus vaginal Misoprostol in termination of first trimester missed abortion<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The occurance of complete abortion within 24 hours with Misoprostol drug | Efficacy of sublingual and vaginal Misoprostol in complete termination of first trimester missed abortion | Within 24 hours | 
| Which route is the best and less side effects in complete termination of first trimester missed abortion by Misoprostol drug | Vaginal versus sublingual route of administration of Misoprostol for complete termination of first trimester missed abortion | within 24 hours |