Study on the Transfusional Management of the Patients With Congenital Heart Disease Carried Out in Adulthood.

Study Overview
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Brief Summary
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Surgeries of heart disease in adulthood can happen in two specific contexts: either for an asymptomatic anomaly, possibly coupled with the onset of symptoms later in life and tardily diagnosed and surgically managed either for a malformation treated in childhood and requiring a new intervention in adulthood. In recent years, the number of adult patients with congenital heart disease has been steadily increasing. Advances in diagnostic techniques and surgical treatments have enabled many children to reach adulthood. The number of these patients is now higher than the number of children with congenital heart disease. The number of these patients having had surgery in adulthood is also increasing. Congenital cardiopathies are numerous, ranging from simpler pathologies such as inter-auricular or inter-ventricular communication, to much more complex pathologies such as situations of univentricular hearts. The surgical treatments of these congenital heart diseases are classified into three groups: initial palliative surgery, initial curative surgery or iterative surgery. Palliative surgery aims to improve the clinical tolerance of the patient to the conditions of his pathology or to prevent complications. The curative surgery restores the physiological circulation, the iterative surgery treats a complication or a degeneration appearing after a curative surgery. Patients undergoing cardiac surgery frequently receive blood products transfusions during the preoperative, intraoperative, or postoperative periods. Several observational studies have shown that in cardiac surgery, the transfusion of blood derivatives is associated with an increase in post-operative morbidity and mortality. The objective of this study is to analyze the predictive factors of transfusion in congenital patients operated in adulthood at Brugmann University Hospital, depending on the type of surgery applied (palliative, curative or iterative). The secondary objective will be to assess whether there are any differences with the predictive factors identified in non-congenital patients undergoing cardiac surgery, which could potentially alter the transfusion approach in congenital patients.

Official Title
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Observational Retrospective Study on the Transfusional Management of the Patients With Congenital Heart Disease Carried Out in Adulthood.

Conditions
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Congenital Heart Defect

Intervention / Treatment
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* Other: Data extraction in medical files


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Cardiac surgery linked to the presence of a heart congenital malformation. Exclusion Criteria: Transfusion refusal from the patient

Ages Eligible for Study
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Minimum Age: 16 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cardiac surgery<br>All adult patients having undergone surgery between January 2006 and December 2016 within the CHU Brugmann hospital. | Other: Data extraction in medical files<br>* Data extraction from medical files, countraverified by the bloodbank database for accuracy.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Demographic data | Demographic characteristics of the patients (descriptive analysis) | 10 years | 
| Co-morbidities | List of co-morbidities (descriptive analysis) | 10 years | 
| Type of surgery | Type of cardiac surgery | 10 years | 
| Blood loss during surgery | Blood loss during surgery | 10 years | 
| Complications during surgery | Complications during surgery: descriptive analysis | 10 years | 
| Complications after surgery | Complications after surgery: descriptive analysis | 10 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Congenital Heart Disease, Blood products transfusion