Pleural Effusion Drainage in Mechanically Ventilated Patients Monitored by EIT

Study Overview
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Brief Summary
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Evacuation of pleural effusion (PE) represents a disputable therapy in mechanically ventilated patients. Patients on mechanical ventilation indicated by the physician to pleural fluid evacuation will be monitored throughout the procedure by electrical impedance tomography (EIT) and concurrently end-expiratory lung volume (EELV) will be measured in order to describe impact of PE evacuation on aeration and ventilation of the lungs.

Detailed Description
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Critically ill patients treated in intensive care units have a disorder of distribution and volume of body fluids due to principal illness and some therapeutic interventions. One of its manifestations is pleural effusion (PE) formation. Patients on mechanical ventilation indicated by treating physician to pleural fluid evacuation will be monitored throughout the procedure by electrical impedance tomography (EIT) and concurrently end-expiratory lung volume (EELV) will be measured. The purpose of the study is to better understand impact of PE evacuation on aeration and ventilation of the lungs.

Official Title
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Effects of the Pleural Effusion Drainage in Mechanically Ventilated Patients Monitored by Electrical Impedance Tomography and End-Expiratory Lung Volume

Conditions
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Pleural Effusion, Drainage, Electric Impedance Tomography

Intervention / Treatment
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* Device: Electrical Impedance Tomography record


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: mechanical ventilation, presence of pleural effusion, decision of the treating physician to drain it Exclusion Criteria: impossibility to apply EIT belt or to find suitable save point for drainage when the EIT belt is attached standard EIT exclusion criteria according to the device manufacturer

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Electrical Impedance Tomography record<br>Electrical Impedance Tomography monitoring of the pleural effusion evacuation. | Device: Electrical Impedance Tomography record<br>* Monitoring of pleural effusion evacuation by means of EIT<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of the thorax electrical impedance following pleural effusion drainage in mechanically ventilated patients | Comparison of EIT results with end-expiratory lung volume measurement during drainage of pleural effusion | 4 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of the distribution of ventilation following pleural effusion drainage in mechanically ventilated patients | Change of distribution of ventilation over EIT regions of interest (ROIs) | 4 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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mechanical ventilation, pleural effusion, EIT