Role of Endothelial Function, Muscular Fitness and Metabolism in Functional Activity in Patients With Chronic Heart Failure (CHF)

Study Overview
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Brief Summary
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Shortness of breath, fatigue, and exercise intolerance are clinical symptoms of chronic heart failure (CHF). Recent studies suggested that peripheral impairment was the major cause of clinical symptoms, and mechanism may be related to neuroendocrine impairment and vascular smooth muscle dysfunction. It results in increased peripheral resistance that may influence limb blood flow, muscle fitness and activities of daily.The purposes of this study are to compare muscular strength, endurance, and perfusion of quadriceps between CHF patients and healthy controls by isokinetic test and near-infrared spectroscopy (NIRS) and difference in activities of daily living to compare endothelium function between CHF patients and healthy control subjects the relationship between endothelium function, muscular strength, endurance, perfusion, and metabolism of quadriceps.

Official Title
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Role of Endothelial Function, Muscular Fitness and Metabolism in Functional Activity in Patients With Chronic Heart Failure

Conditions
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Chronic Heart Failure, Coronary Disease, Dilated Cardiomyopathy

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 40-75 years Chronic heart failure: ejection fraction<40% and at stable condition Coronary Disease and dilated cardiomyopathy without heart failure Control group without diagnosis of any heart disease Exclusion Criteria: Clinical diagnosis of neuromusculoskeletal , pulmonary, or other systemic diseases that may affect the testing of the study

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cardiovascular disease<br>Diagnosis of cardiomyopathy or ischemic heart disease without heart failure | |
| Chronic heart failure<br>Diagnosis of cardiomyopathy or ischemic heart disease LVEF <40% | |
| Control<br>Age and body built matched with chronic heart failure group | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| muscle strength and endurance | Measured by biodex | baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| skeletal muscle oxygenation response | Measured by near-infrared spectroscopy | baseline | 
| Walking distance in 6-minute walking test | walking distance (m) | baseline | 
| laser Doppler flowmetry combine iontophoresis | To measure the blood flux (PU) response to Ach (endothelial-dependent agent) and SNP (endothelial-independent agent) | baseline | 
| sit-to-stand test | Measured times in 1 minute | baseline | 
| questionnaire (functional activity and quality of life) |  | baseline | 
| Analysis of venous blood sample | By standard venipuncture | baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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chronic heart failure, isokinetic test, near-infrared spectroscopy, laser Doppler flowmetry, endothelial function