Periodic Limb Movement and Genetic Generalized Epilepsy

Study Overview
=================
Brief Summary
-----------------
The study aimed to study the correlation between periodic limb movement occurring during sleep and the different parameters of genetic generalized epilepsy

Detailed Description
-----------------
Although periodic limb movements are prevalent among patients with epilepsy, the exact relationship between these movements and epilepsy remains elusive. Objective: The aim of this work was to study the periodic limb movements among patients with genetic generalized epilepsy in relation to different clinical characteristics and seizure recurrence. Methods: Sixty individuals participated in this study: thirty of them were newly diagnosed with genetic generalized epilepsy and thirty were healthy individuals. Sleep quality was assessed using the Pittsburgh Sleep Quality Index questionnaire, and a standard polysomnographic study was conducted to all subjects. All patients then received sodium valproate in therapeutic doses and were followed up for six months. Electroencephalogram (EEG) was done after the follow-up period and seizure recurrence was assessed. Accordingly, patients were classified into three groups according to clinical seizure recurrence and follow-up EEG findings. Periodic limb movement index and frequency were compared among the patients' groups and were correlated with different clinical characteristics.

Official Title
-----------------
The Relationship Between Periodic Limb Movement and Seizure Recurrence in Genetic Generalized Epilepsy

Conditions
-----------------
Epilepsy Generalized Idiopathic Not Intractable

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Newly diagnosed with genetic generalized epilepsy according to the ILAE 2010 criteria did not previously receive AEDs. The clinical seizures were either eyewitnessed by physicians or video-recorded to ensure they were true epileptic seizures. At least two unprovoked seizures occurring >24 hours apart Exclusion Criteria: Patients with pre-existing psychiatric illnesses Patients with seizures due to toxic or metabolic causes (including glucose disturbance, uremia, and electrolytes disturbance), infections, or structural causes (such as neoplasms) Patients using hypnotic drugs

Ages Eligible for Study
-----------------
Minimum Age: 9 Years
Maximum Age: 29 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients: group<br>Group I (n=10) included patients who did not develop any major or minor seizure during the follow-up period and their follow up EEG was free of any epileptiform discharge | |
| Patients: group II<br>Group II (n=11) included patients who developed only minor seizures and their follow up EEG showed epileptiform discharge | |
| Patients: group III<br>Group III (n=9) were patients who developed one or more major seizures during the follow-up period whatever their EEG findings. | |
| Controls<br>healthy volunteers (n=30) who were not related to the patients and had no family history of epilepsy. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Seizure recurrence | Clinical major or minor seizure, and electrical seizure | 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Generalized epilepsy, idiopathic, periodic limb movement