Treatment of Internal Inflammatory Root Resorption Using Injectable PRF Revascularization Technque

Study Overview
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Brief Summary
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Currently Endodontics looks forward for regeneration rather than repair. Regenerative endodontic therapy was limited to pulp revascularization of necrotic pulp in immature teeth , followed by mature teeth. Recently pulp revascularization technique by induction of blood clot was applied in the treatment of inflammatory root resorption. So far, no clinical study for management of teeth with inflammatory internal root resorption by using injectable PRF revascularization has been described in the literature. Thus, this is the first clinical attempt to manage inflammatory root resorption in necrotic incisor teeth using injectable PRF regenerative approach.

Detailed Description
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13 teeth in a total of 10 patients with inflammatory root resorption will be treated using revascualrization technique, iPRF will be prepared and unjected in the canal after previous canal disinfection with calcium hydroxide for 2-4 weeks. cBCT will be taken preoperative and 12 month follow up period, also clinical and radiographic follow uo will be considered every 3 months for 1 year.

Official Title
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Treatment of Internal Inflammatory Root Resorption Using Injectable PRF Revascularization Technique: A Clinical Study With Cone Beam Computed Tomography Evaluation

Conditions
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Root Resorption

Intervention / Treatment
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* Biological: injectable PRF


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients 13-30 years old no sex predilection medically free Suffering from internal inflammatory root resorption in permanent anterior mature teeth associated with or without periapical radiolucency no or grade I tooth mobility, and a pocket depth <3 mm Exclusion Criteria: old age Medically medically compromised patients

Ages Eligible for Study
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Minimum Age: 13 Years
Maximum Age: 30 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: injectabl PRF for treatment of internal root resorption<br> | Biological: injectable PRF<br>* blood sample and centrifuged to obtain i-PRF<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change in volumetric size of internal root resorption lesions | Measuring volumetric dimensions of resorption lesion pre and postoperatively using CBCT | 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change in volumetric size of periapical lesions | Measuring volumetric dimensions of periapical lesion pre and postoperatively using CBCT | 12 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Pulp revascularization, injectable Platelet rich fibrin, root resorption, CBCT, i-PRF