Sonographic Signs of Gouty Arthritis in a Cohort of Egyptian Patients: a Cross Sectional Multicenter Study

Study Overview
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Brief Summary
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The study is a cross sectional observational multicenter study. It is established in collaboration with the Egyptian college of rheumatology study group (ECRsg). It is conditioned that all the study participants had either mono- or oligo-arthritis with effusion of the knee or the first metatarsophalangeal (MTP) joint in patients with a known history of gout or at high risk. Patients with any known chronic arthritis, comprising rheumatoid arthritis, Sjogren's syndrome, systemic lupus erythematosus, scleroderma, neuropathic arthritis, seronegative spondyloarthropathy, will be excluded from the study. None of the participants had a history of intra-articular injection or aspiration in the scanned joints for 3 months prior to the inclusion in the study. The sonographers will be blinded for clinical data and the EULAR scanning protocol for the knee and 1st MTP will be considered [2]. Further, scanning of the double contour sign over the femur condyles anteriorly and posteriorly in sagittal planes will be assessed. All the sonographers in the study had an experience between 5 and 10 years in the field of musculoskeletal ultrasound.

Official Title
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Sonographic Signs of Gouty Arthritis in a Cohort of Egyptian Patients: a Cross Sectional Multicenter Study

Conditions
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Sonographic Signs of Gouty Arthritis in Diagnosed and Suspected Patients

Intervention / Treatment
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* Diagnostic Test: Evaluation of sonographic signs of gouty arthritis


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: mono- or oligo-arthritis with effusion of the knee or the first metatarsophalangeal patients with a known history of gout or at high risk Exclusion Criteria: Patients with any known chronic arthritis, comprising rheumatoid arthritis, Sjoegren's syndrome, systemic lupus erythematosus, scleroderma, neuropathic arthritis, seronegative spondyloarthropathy History of intra-articular injection in the last 3 months.

Ages Eligible for Study
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Minimum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Sohag university recruited patients<br> | Diagnostic Test: Evaluation of sonographic signs of gouty arthritis<br>* the EULAR scanning protocol for the knee and 1st MTP will be considered [2]. Further, scanning of the double contour sign over the femur condyles anteriorly and posteriorly in sagittal planes will be assessed. Examination of erosions, tophus, double contour, effusion, and echogenic foci will be recorded.<br>|
| Minia university recruited patients<br> | Diagnostic Test: Evaluation of sonographic signs of gouty arthritis<br>* the EULAR scanning protocol for the knee and 1st MTP will be considered [2]. Further, scanning of the double contour sign over the femur condyles anteriorly and posteriorly in sagittal planes will be assessed. Examination of erosions, tophus, double contour, effusion, and echogenic foci will be recorded.<br>|
| Assuit university recruited patients<br> | Diagnostic Test: Evaluation of sonographic signs of gouty arthritis<br>* the EULAR scanning protocol for the knee and 1st MTP will be considered [2]. Further, scanning of the double contour sign over the femur condyles anteriorly and posteriorly in sagittal planes will be assessed. Examination of erosions, tophus, double contour, effusion, and echogenic foci will be recorded.<br>|
| Kasr Elini recruited patients<br> | Diagnostic Test: Evaluation of sonographic signs of gouty arthritis<br>* the EULAR scanning protocol for the knee and 1st MTP will be considered [2]. Further, scanning of the double contour sign over the femur condyles anteriorly and posteriorly in sagittal planes will be assessed. Examination of erosions, tophus, double contour, effusion, and echogenic foci will be recorded.<br>|
| Tanta university recruited patients<br> | Diagnostic Test: Evaluation of sonographic signs of gouty arthritis<br>* the EULAR scanning protocol for the knee and 1st MTP will be considered [2]. Further, scanning of the double contour sign over the femur condyles anteriorly and posteriorly in sagittal planes will be assessed. Examination of erosions, tophus, double contour, effusion, and echogenic foci will be recorded.<br>|
| Monofia university recruited patients<br> | Diagnostic Test: Evaluation of sonographic signs of gouty arthritis<br>* the EULAR scanning protocol for the knee and 1st MTP will be considered [2]. Further, scanning of the double contour sign over the femur condyles anteriorly and posteriorly in sagittal planes will be assessed. Examination of erosions, tophus, double contour, effusion, and echogenic foci will be recorded.<br>|
| Aswan university recruited patients<br> | Diagnostic Test: Evaluation of sonographic signs of gouty arthritis<br>* the EULAR scanning protocol for the knee and 1st MTP will be considered [2]. Further, scanning of the double contour sign over the femur condyles anteriorly and posteriorly in sagittal planes will be assessed. Examination of erosions, tophus, double contour, effusion, and echogenic foci will be recorded.<br>|
| Ain shams university recruited patients<br> | Diagnostic Test: Evaluation of sonographic signs of gouty arthritis<br>* the EULAR scanning protocol for the knee and 1st MTP will be considered [2]. Further, scanning of the double contour sign over the femur condyles anteriorly and posteriorly in sagittal planes will be assessed. Examination of erosions, tophus, double contour, effusion, and echogenic foci will be recorded.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sonographic signs of gouty arthritis in the knee or 1st MTP joint | Erosions, effusion, echogenic foci, and tophus using OMERACT definitions of sonographic signs of gouty arthritis | at baseline |