The Affect of Low-Volume Bowel Preparation for Hospitalized Patients Colonoscopies

Study Overview
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Brief Summary
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The purpose of this study is to compare the efficacy of a low-volume bowel preparation versus a high-volume bowel preparation for bowel cleansing on hospitalized patients undergoing colonoscopies.

Official Title
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The Affect of Low-Volume Bowel Preparation for Hospitalized Patients Colonoscopies

Conditions
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Colonoscopy

Intervention / Treatment
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* Drug: Low volume prep (Prepopik)
* Drug: Moderate volume prep (Moviprep)
* Drug: High volume prep (Golytely)


Participation Criteria
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Eligibility Criteria
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Inclusion criteria: Inpatient colonoscopy Age 18 years and older Able to give consent Split dose colonoscopies for all patients Exclusion criteria: Unable to give consent Pregnant or lactating women Renal impairment (GFR <30) Ileus Ascites Toxic megacolon Gastrointestinal obstruction Allergy to study drugs Toxic colitis Not able to split the dose of bowel preparations to be used Contraindication to bowel preparation Risk for aspiration Risk of severe cardiac arrhythmias

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Low volume prep (Prepopik)<br>Low volume prep for colonoscopy (Prepopik) | Drug: Low volume prep (Prepopik)<br>* Hospitalized patients will be randomized to receive either large volume bowel preparation (Golytely), moderate volume bowel prep (Moviprep) or low volume bowel preparation (Prepopik) in a split dose manner for bowel cleansing prior to colonoscopy.<br>* Other names: Prepopik;|
| Active Comparator: Moderate volume prep (Moviprep)<br>Moderate volume prep for colonoscopy (Moviprep) | Drug: Moderate volume prep (Moviprep)<br>* Hospitalized patients will be randomized to receive either large volume bowel preparation (Golytely), moderate volume bowel prep (Moviprep) or low volume bowel preparation (Prepopik) in a split dose manner for bowel cleansing prior to colonoscopy.<br>* Other names: Moviprep;|
| Active Comparator: High volume prep (Golytely)<br>High volume prep for colonoscopy (Golytely) | Drug: High volume prep (Golytely)<br>* Hospitalized patients will be randomized to receive either large volume bowel preparation (Golytely), moderate volume bowel prep (Moviprep) or low volume bowel preparation (Prepopik) in a split dose manner for bowel cleansing prior to colonoscopy.<br>* Other names: Golytely;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Bowel Cleansing | Measured using the total Boston Bowel Prep Score (BBPS) obtained by adding scores from each segment for a range of minimum 0 = very poor and maximum 9 = excellent. | 24 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cancellation or Delay of Procedure Due to Poor Bowel Preparation | To assess the rate of delayed and or cancellation of procedure due to inadequate bowel preparation | 24 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Colonoscopy