Risk Factors for Staphylococcus Aureus Surgical Site Infections in Orthopedic and Trauma Surgery

Study Overview
=================
Brief Summary
-----------------
The most commonly identified organism for Surgical Site Infection (SSI) in orthopedic surgery is Staphylococcus aureus but risk factors for mono microbial S.aureus SSI are not well-known. The aim of this study was to evaluated the incidence rate of S. aureus SSI over the years and risk factors of these infections in a french University Hospital.

Detailed Description
-----------------
Surgical site infections (SSI) in orthopedic surgery are responsible for reduced quality of life, increased length of hospital stay and costs. The most commonly identified organism is Staphylococcus aureus but risk factors for mono microbial S.aureus SSI are not well-known.The aim of this study was to evaluate the incidence rate trend of S. aureus SSI over the years and risk factors of theses infections in a french University Hospital. The knowledge obtained by this study will enable identification of the surgical patients most at risk of developping S. aureus SSI, and who would probably benefit most from new interventions given prophylactically and specifically to prevent S. aureus infections.

Official Title
-----------------
Risk Factors for Staphylococcus Aureus Surgical Site Infections in Orthopedic and Trauma Surgery

Conditions
-----------------
Staphylococcus Aureus, Surgical Wound Infection, Orthopedic Disorder, Traumatology

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: orthopedic or traumatology surgeries performed in Grenoble University Hospital, from january 1st 2012 to april 30th 2015, the subject is undergoing one of the following surgical procedures : knee and hip arthroplasties, osteosynthesis of proximal femur and other osteosynthesis except skull and spine. the subject is 16 years of age or older Exclusion Criteria: non orthopedic or trauma surgery performed in Grenoble University Hospital, spine surgeries, surgeries of the hand, scaphoid and carpal bones.

Ages Eligible for Study
-----------------
Minimum Age: 16 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Risk factors of S. aureus surgical site infections. | univariate analysis of potential risk factors. Data with p value less than 0.1 were included in a logistic regression model | up to 1 year following surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The incidence rate trend of S. aureus SSI over the year. | linear regression slope test of S. aureus SSI incidence rates by years | from january 1st 2012 to april 30th 2015 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Gram-positive bacterial infections, bacterial infections, infection, wound infection, surgical wound infection, Staphylococcal infections, wound and injuries, postoperative complications