Analysis of Driver Gene Mutation in Early Stage Non-small Cell Lung Cancer

Study Overview
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Brief Summary
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Analysis of driver gene variation in early stage non-small cell lung cancer

Detailed Description
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Fluorescence quantitative polymerase chain reaction (PCR) was used to detect the variation of driver gene in regional lymph nodes of early stage non-small cell lung cancer (NSCLC), and to analyze the relationship between the variation and disease recurrence and survival prognosis. evaluate the effect of the variation of driving gene in lymph nodes of early stage NSCLC on prognosis, identify the high-risk factors that promote the recurrence and metastasis of early stage tumor. so as to improve the diagnosis and treatment path of lung cancer, provide important pathological basis for the clinical diagnosis and treatment of early stage non-small cell lung cancer, enable patients to receive more accurate treatment, and improve their survival prognosis.

Official Title
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Molecular Metastasis in Lymph Nodes is Associated With Survival of Patients With Stage I NSCLC

Conditions
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Non-small Cell Lung Cancer

Intervention / Treatment
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* Other: nonIntervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Female or male, 18 years of age or older Histologically or cytologically proven diagnosis of early stage NSCLC The lesion was completely resected by radical surgery Able to get tumor tissue sample Complete information of clinicopathological , survival, recurrence and metastasis can be obtained through follow-up Exclusion Criteria: Combine with other tumor type The investigator judges the situation that may affect the clinical search process and results

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Driver gene mutation-positive<br>Screen the enrolled patients according to the admission criteria. The detection of lung cancer Polymerase Chain Reaction (PCR) panel kit in the hospital requires the use of tissue samples and the results show a driver gene mutation positive. | Other: nonIntervention<br>* nonIntervention<br>|
| Driver gene mutation-negative<br>Screen the enrolled patients according to the admission criteria. The detection of lung cancer Polymerase Chain Reaction (PCR) panel kit in the hospital requires the use of tissue samples and the results show a driver gene mutation negative. | Other: nonIntervention<br>* nonIntervention<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Driver gene mutation frequency of early stage NSCLC | Observe the driver gene mutation frequency in regional lymph nodes of early stage non-small cell lung cancer | 2019 | 
| Correlation of Clinicopathological characteristics and driver gene mutation in regional lymph nodes of early stage NSCLC | Analyze the correlation between driver gene mutation and clinicopathological features in regional lymph nodes of early stage NSCLC | 2019 | 
| Correlation between driver gene mutation and survival prognosis in regional lymph nodes of early stage NSCLC | Observe the correlation between driver gene mutation and survival prognosis in regional lymph nodes of early stage NSCLC | 2019 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Regional Lymph nodes, Molecular metastasis, Driver gene mutation