Impact of Von Willebrand Factor and Its Multimers on Angiogenesis

Study Overview
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Brief Summary
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The study aims to study the expression of numerous proteins involved in angiogenesis in 70 patients with von Willebrand disease in order to try to identify markers of interest. Secondly, the investigators plan to investigate whether there is a relationship between the proteins tested, the distribution of multimers and the clinical phenotype of the patients, in particular by looking for the presence of bleeding linked to the presence of angiodysplasias.

Official Title
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Impact of Von Willebrand Factor and Its Multimers on Angiogenesis

Conditions
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Von Willebrand Diseases

Intervention / Treatment
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* Other: no intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: For patients: Patient with von Willebrand disease proven by genetic analysis of the VWF gene. Lack of treatment that could interfere with angiogenesis. Patient informed by an information note sent to his home, with the possibility of objecting to the use of his blood samples in the context of research. For the control: Patient with a normal coagulation report Absence of abnormal hemorrhagic symptoms Lack of notion of angiodysplasia. Lack of treatment that could interfere with angiogenesis. Patient informed by an information note sent to his home, with the possibility of objecting to the use of his blood samples in the context of research. Exclusion Criteria: Patient under guardianship or curatorship. Pregnant and lactating women. Blood transfusion or treatment with von Willebrand factor concentrates less than 7 days old. Treatment which may interfere with angiogenesis.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| patients with von Willebrand disease<br> | Other: no intervention<br>* no intervention<br>|
| case control<br> | Other: no intervention<br>* no intervention<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To study the relationship between proteins involved in angiogenesis and the distribution of multimers in patients with von Willebrand disease in order to define markers of interest | Compare the distribution of multimers assays between different groups of patients and the control group | 1 year | 
| To study the relationship between proteins involved in angiogenesis and the distribution of multimers in patients with von Willebrand disease in order to define markers of interest | Compare the distribution of protein assays between different groups of patients and the control group | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To study the relationship between the distribution of multimers and the clinical phenotype of patients, and in particular the presence of angiodysplasias | To study the correlation between the clinical phenotype and the assays of angiogenesis proteins | 1 year | 
| To study the relationship between the markers of interest and the clinical phenotype of patients, and in particular the presence of angiodysplasias | To study the correlation between the clinical phenotype and the distribution of multimers | 1 year |