Decision Making, Daily Experiences, and Brain Activity in Young Adult Women

Study Overview
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Brief Summary
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The investigators are doing a study of women with and without binge-eating disorder to learn more about what happens when people engage in everyday decision-making activities. The investigators are interested in learning more about brain activity during everyday decision-making and how everyday decision-making relates to a variety of daily experiences. Examples of everyday decisions include deciding which product to buy, deciding what to eat for a snack, and deciding how to spend free time.

Official Title
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Understanding The Effects of Acute Stressors and Negative Emotion on Eating Behavior in Binge-Eating Disorder: The Role of Stressor-Induced Changes in Reward and Cognitive Control

Conditions
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Binge-Eating Disorder

Intervention / Treatment
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* Behavioral: Speaking Activity
* Behavioral: Talking Activity


Participation Criteria
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Eligibility Criteria
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INCLUSION CRITERIA: Inclusion Criteria for All Participants: Normal or corrected to normal vision and hearing Verbal and written fluency in English Right-handed Body mass index of 20-35 kg/m^2 Additional Inclusion Criteria for Participants with Binge-Eating Disorder: • DSM-5 binge-eating disorder EXCLUSION CRITERIA: Exclusion Criteria for All Participants: Impaired cognition or other neurological/cognitive problems Contraindications to MRI (e.g., certain metal implants, claustrophobia) Currently/recently/potentially pregnant, seeking to become pregnant in the near future, or breastfeeding Serious and/or unstable medical diseases and conditions, and certain other medical diseases and conditions Recent low weight Certain medications (e.g., insulin) Current/recent frequent recreational drug use, or history of frequent recreational drug use in early adolescence Extreme dietary limitations (e.g., veganism), pervasive food allergies, or limited exposure to popular snack foods Current/recent suicidality Current/recent changes in treatment for mental illness Study-relevant research experience Additional Exclusion Criteria for Comparison Participants: Personal history of eating disorders or recurrent binge eating Personal history of any other mental illness, including serious substance use problems First-degree relative with current or past eating or psychotic disorder Significant recent change in weight Additional Exclusion Criteria for Participants with Binge-Eating Disorder: Severe mental illness (e.g., psychotic disorder, severe agoraphobia) Certain other current/recent mental illness, including severe substance use problems, that would limit study participation or safety Recent anorexia nervosa spectrum disorder, avoidant-restrictive food intake disorder, or bulimia nervosa spectrum disorder

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Speaking Activity and Talking Activity<br>Participants will engage in a speaking activity first and a talking activity second. | Behavioral: Speaking Activity<br>* Participants will engage in a speaking activity where they are given a topic to speak about.<br>Behavioral: Talking Activity<br>* Participants will engage in a talking activity where they may talk about a topic of their choice.<br>|
| Experimental: Talking Activity and Speaking Activity<br>Participants will engage in a talking activity first and a speaking activity second. | Behavioral: Speaking Activity<br>* Participants will engage in a speaking activity where they are given a topic to speak about.<br>Behavioral: Talking Activity<br>* Participants will engage in a talking activity where they may talk about a topic of their choice.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Decision-making behavior (actual decisions) | Decisions (i.e., percent of goal-inconsistent decisions from challenge trials) | Up to 1 hour post-intervention | 
| Decision-related BOLD activation (reward regions-of-interest) | Percent change in blood oxygen level-dependent (BOLD) signal in response to decision making in regions involved in reward (e.g., nucleus accumbens, insula) | Up to 1 hour post-intervention | 
| Decision-related BOLD activation (executive function regions-of-interest) | Percent change in blood oxygen level-dependent (BOLD) signal in response to decision making in regions involved in executive function (e.g., dorsolateral prefrontal cortex, inferior frontal gyrus) | Up to 1 hour post-intervention | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Binge-Eating Disorder, Decision-Making, Brain Activity