ObseRvation of PeripHEral rEtinal Morphology in Normals

Study Overview
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Brief Summary
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To develop a database of the peripheral choroidal circulation using ultra widefield (UWF) imaging. This database will serve as a quantitative reference tool for the comparison of subjects to a database of known normal subjects.

Official Title
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ObseRvation of PeripHEral rEtinal Morphology in Normal

Conditions
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Healthy

Intervention / Treatment
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* Other: Indocyanine Green ICG


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Subjects older than 20 years old with good general health. Subject is capable of giving consent. The subject is able and willing to comply with the study procedures. Subjects with ocular media clear enough to allow good quality ocular imaging. Normal subjects with no known retinal or choroidal disease. Exclusion Criteria: Subjects under 20 years old. Subjects with contraindications to dilation. Subjects with a history of epilepsy. Subjects with a known allergy to iodine, shellfish or intra-venous x-ray contrast dyes. Subjects who are or who may be pregnant. Subjects with past history of any vitreoretinal disease or surgery such as retinal detachment, epiretinal membrane, or vitreous hemorrhage. Subjects with any ocular condition that interferes with good quality image acquisition, such as corneal opacities, cataract, and dense vitreous hemorrhage. Subjects with any evidence of any retinal or optic nerve disease including glaucoma. Subjects with any anterior segment disease with the exception of common ocular surface disorders (blepharitis, dry eye). Subjects with medical conditions that interfere with the subject's compliance to study procedures such as inability of the subject to maintain steady head or eye positioning as in patients of ataxia or nystagmus. Subjects with a history of Diabetes, uncontrolled blood pressure (defined as systolic >/= 160mmHg and/or diastolic >/= 90 mmHg), and Vascular Disease (cardiovascular, peripheral vascular, or cerebrovascular). Subjects on vasodilators. Subject's refusal.

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Normals<br>Subjects with normal visual and retinal function will be enrolled | Other: Indocyanine Green ICG<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Develop a database of peripheral retinal circulation in normals using UWF-ICG imaging |  | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Develop a database of peripheral retinal morphology on age stratified normals using color, AF and ICG imaging |  | 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Normal, Healthy, Normal healthy patient