Cortical Plasticity in Spastic Diplegia After Selective Dorsal Rhizotomy

Study Overview
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Brief Summary
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The purpose of this study is to characterize the cortical connectivity changes in the brain of spastic diplegic children after Selective Dorsal Rhizotomy.

Detailed Description
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To establish the structural changes in the corticopyramidal tract using diffusion tractography imaging (DTI) due to selective dorsal rhizotomy and compare the resting state functional connectivity(rsfcMRI) temporal latency differences of spastic diplegics for Selective Dorsal Rhizotomy.

Official Title
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Cortical Plasticity in Spastic Diplegia After Selective Dorsal Rhizotomy

Conditions
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Spastic Diplegia

Intervention / Treatment
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* Procedure: 3Tesla MRI with DTI-MRI and rsfcMRI under general anesthesia


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Children diagnosis with Spastic Diplegia and having Selective Dorsal Rhizotomy surgery Exclusion Criteria: No Selective Dorsal Rhizotomy surgery

Ages Eligible for Study
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Minimum Age: 3 Years
Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: 3Tesla MRI with DTI-MRI and rsfcMRI<br>Patients will receive 2 post-operative MRI's with DTI and rsfcMRI at 2 months and 12 months. | Procedure: 3Tesla MRI with DTI-MRI and rsfcMRI under general anesthesia<br>* 2 post-operative MRI's at 2 months and 12 months<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Fractional Anisotropy as assessed by brain MRI with diffusion tractography imaging (DTI) sequences | This measure will be used to assess changes in the lower extremity fibers corticopyramidal tract after Selective Dorsal Rhizotomy (SDR). | Baseline and 12 months | 
| Change in Mean Diffusivity as assessed by brain MRI with diffusion tractography imaging (DTI) sequences | This measure will be used to assess changes in the lower extremity fibers corticopyramidal tract Selective Dorsal Rhizotomy (SDR). | Baseline and 12 months | 
| Change in Radial Diffusivity as assessed by brain MRI with diffusion tractography imaging (DTI) sequences | This measure will be used to assess changes in the lower extremity fibers corticopyramidal tract after Selective Dorsal Rhizotomy (SDR) | Baseline and 12 months | 
| Change in Axial Diffusivity as assessed by brain MRI with diffusion tractography imaging (DTI) sequences | This measure will be used to assess changes in the lower extremity fibers corticopyramidal tract after Selective Dorsal Rhizotomy (SDR) | Baseline and 12 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cerebral Palsy