Objective Choroidal Thickness Measurements in Uveitis

Study Overview
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Brief Summary
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Optical Coherence Tomography (OCT) machines are non-contact instruments that can provide micrometer scale imaging of biological tissue. Applying the image processing allows us to automatically measure the choroidal thickness with good interclass correlation coefficient to the manual measurements.

Official Title
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Objective Choroidal Thickness Measurements During Intraocular Inflammation in Uveitis Using Optical Coherence Tomography

Conditions
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Uveitis

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: To the control group - ability to perform OCT examination To the uveitis group - with one or more of the following clinical features (as indicators for active state of the disease): >1+ anterior chamber cells; >1+ vitreous haze; presence of vitreous cells; presence of blood in anterior chamber; presence of blood in vitreous; presence of aqueous or vitreous pigment. Exclusion Criteria: To the control group - diagnosed uveitis In case of all groups: inability to give informed consent; inability to maintain stable fixation for OCT imaging.
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Uveitis group<br> | |
| Control group<br>age and sex matched group to the uveitis group | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Submacular choroidal thickness in different stages of the disease | OCT EDI recordings processed with developed by researchers methodology for image processing | 5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| ETDRS Visual Acuity | Visual Acuity will be performed with ETDRS charts different for right and left eye | 1 year | 
| The SUN working group grading system for anterior chamber cells | At each visit anterior chamber will be examined to assess anterior chamber cells (1mm x 1mm slit beam in height and width, when thrown at an angle of 45-60°). The recorded number of cells will be used to determine the grade according to the SUN criteria. | 1 year | 
| The SUN working group grading system for anterior chamber flare | At each visit anterior chamber will be examined to assess anterior chamber flare (1mm x 1mm slit beam in height and width, when thrown at an angle of 45-60°). The observed changes will be used to determine the grade according to the SUN criteria. | 1 year | 
| AREDS 2008 Clinical Lens Opacity Grading Procedure | Using AREDS system for classifying cataracts from photographs: AREDS Report No. 4 the lens opacity will be graded | 1 year | 
| NIH grading system for vitreous cells | At each visit vitreous will be examined to assess vitreous cells (1mm x 3mm slit beam in anterior vitreous). The recorded number of cells will be used to determine the grade according to the NIH criteria. | 1 year | 
| NIH grading system for vitreous haze | At each visit vitreous will be examined to assess vitreous haze. The recorded of clarity of posterior pole funduscopy will be used to determine the grade according to the NIH criteria. | 1 year |