The Effect of Chronic Anemia on Safety Period of Tracheal Intubation in Gynecology Patients

Study Overview
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Brief Summary
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Every individual receiving a general anesthetic is at potential risk for developing a ''cannot intubate-cannot ventilate'' situation following anesthetic induction. Building up of oxygen reserves assumes great significance as this provides a longer duration of non-hypoxic apnea should one be faced with an unanticipated difficult airway. The main physiological functions of red blood cell hemoglobin are to deliver oxygen to the peripheral tissues. During anemia, a reduction in blood oxygen content occurs as a result of reduced Hb while arterial oxygenation and oxyhemoglobin saturation remain high. Previous studies about the duration of non-hypoxic apnoea focus on methods to improve the safety period of tracheal intubation. To our knowledge, there is no literature about the duration of non-hypoxic apnoea of anemia patients. The aim of this study was to assess the effect of chronic anemia on the duration of non-hypoxic apnoea during induction of anaesthesia.

Detailed Description
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After breathing for 3 minutes, anesthesia induction was conducted. The endotracheal tube position was confirmed after anesthesia induction. Patients were left apneic with the endotracheal tube open to room air. The non-hypoxic apneic period was recorded as the time (in seconds) taken for the drop in pulse saturation to 90% or an apneic period of 10 min elapsed, whichever was earlier.

Official Title
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The Effect of Chronic Anemia on Safety Period of Tracheal Intubation in Gynecology Patients

Conditions
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Chronic Anemia

Intervention / Treatment
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* Biological: pre-oxygen


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients scheduled to undergo general anesthesia American Society of Anesthesiologists Performance Status 1-2 adults Exclusion Criteria: Individuals with significant cardiorespiratory or cerebrovascular disease, difficult intubation history of epilepsy body mass index >25 kg/m2, and those who had smoking history in past 6 months

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Group A<br>the hemoglobin is >12g/L in patients from group A. | Biological: pre-oxygen<br>* 3 min of preoxygenation before anesthesia induction.<br>|
| Experimental: Group B<br>Hb 9-12g/L | Biological: pre-oxygen<br>* 3 min of preoxygenation before anesthesia induction.<br>|
| Experimental: Group C<br>Hb<9g/L | Biological: pre-oxygen<br>* 3 min of preoxygenation before anesthesia induction.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| duration of non-hypoxic apnoea |  | up to 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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anemia, non-hypoxic apnoea, tracheal intubation, anesthesia