Qualitative and Quantitative Evaluation of Anosmia Over Time in Clinically Symptomatic Patients Tested for COVID-19 Infection

Study Overview
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Brief Summary
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Loss of sense of smell and taste has been anecdotally reported during the covid-19 epidemic. The study investigators wanted to describe the prevalence of olfactory and gustatory dysfunction and assess the factors associated with positive SARS-CoV-2 infection.

Official Title
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Qualitative and Quantitative Evaluation of Anosmia Over Time in Clinically Symptomatic Patients Tested for COVID-19 Infection

Conditions
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COVID-19

Intervention / Treatment
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* Other: olfactory and gustatory tests


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients presenting with COVID-19 related symptoms including: fever, persistent cough, fatigue, shortness of breath, diarrhoea, abdominal pain, chest pain, sore throat, loss of smell or taste Subjects in prolonged contact with COVID-19 infected patients. Exclusion Criteria: Patients directly admitted to the intensive care unit were excluded Patients opposing use of their health data

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| RT-PCR SARS-CoV-2 positive<br> | Other: olfactory and gustatory tests<br>* Participants rate quality of sense of smell and taste. Olfaction test: Sniff 10ml test tube containing 1.5ml air freshner (Mifleur Citron, Coldis, Entraigues sur Sorgues, France) and rate perception of odor. Gustatory test: Taste a pinch and sugar and salt and rate perception of sweet or salty taste<br>|
| RT-PCR SARS-CoV-2 negative<br> | Other: olfactory and gustatory tests<br>* Participants rate quality of sense of smell and taste. Olfaction test: Sniff 10ml test tube containing 1.5ml air freshner (Mifleur Citron, Coldis, Entraigues sur Sorgues, France) and rate perception of odor. Gustatory test: Taste a pinch and sugar and salt and rate perception of sweet or salty taste<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| SARS-CoV-2 infection status | Positive/negative according to RT-PCR assay | Day 0 | 
| Olfactory and gustatory loss | Custom-designed questionnaire (28 questions pertaining to symptoms, sense of smell and taste) | Day 0 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ability to detect odor | Ability to smell 1.5ml air freshner on a 0-100 VAS scale | Day 0 | 
| Ability to detect odor | Ability to smell 1.5ml air freshner on a 0-100 VAS scale | Six months | 
| Ability to detect salty taste | Ability to taste a pinch of table salt on a 0-100 VAS scale | Day 0 | 
| Ability to detect salty taste | Ability to taste a pinch of table salt on a 0-100 VAS scale | Six months | 
| Ability to detect sweet taste | Ability to taste a pinch of sugar on a 0-100 VAS scale | Day 0 | 
| Ability to detect sweet taste | Ability to taste a pinch of sugar on a 0-100 VAS scale | Six months | 
| Olfactory and gustatory loss | Custom-designed questionnaire (28 questions pertaining to symptoms, sense of smell and taste) | Day 7 | 
| Olfactory and gustatory loss | Custom-designed questionnaire (28 questions pertaining to symptoms, sense of smell and taste) | Day 14 | 
| Olfactory and gustatory loss | Custom-designed questionnaire (28 questions pertaining to symptoms, sense of smell and taste) | Day 30 | 
| Olfactory and gustatory loss | Custom-designed questionnaire (28 questions pertaining to symptoms, sense of smell and taste) | Day 60 | 
| Severity of infection according to hospitalization rate | % patients hospitalized | End of study (six months) | 
| Olfactory and gustatory loss | Custom-designed questionnaire (28 questions pertaining to symptoms, sense of smell and taste) | Six months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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anosmia, SARS-Cov-2