linjc16/ctgov huggingface dataset:
Embryonic Ploidy Status in the Oncofertility Population

Study Overview
=================
Brief Summary
-----------------
looking at aneuploidy rates in embryos from patients who are going to or have undergone treatment for a malignancy with gonadotoxic treatment.

Detailed Description
-----------------
The study involves oncofertility patients--individuals who are undergoing or have undergone therapy for a malignancy--who are interested in pursuing or preserving fertility. In particular, it investigates chromosomal abnormalities or aneuploidy in the embryos of those individuals as compared to the general infertility population. Embryonic aneuploidy is largely due to reproductive senescence. As such the investigators will discuss oncofertility prevalence and treatment as well as reproductive senescence and assessment of embryonic aneuploidy. The study will seek to determine if there are changes in embryonic aneuploidy rates in oncofertility patients that differ from simple age related risks.

Official Title
-----------------
Embryonic Ploidy Status in the Oncofertility Population

Conditions
-----------------
Oncology, Fertility

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 1.Present or past oncologic diagnosis requiring potentially gonadotoxic treatment Exclusion Criteria: Oocyte banking Use of oocyte donation Any contraindications to undergoing in vitro fertilization or gonadotropin stimulation Single gene disorder requiring more detailed embryo genetic analysis

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| oncofertility patients<br>oncofertility patients undering controlled ovarian hyperstimulation and embryo cryopreservation who carry a present or past cancer diagnosis | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| embryonic aneuploidy rates | to evaluate the incidence of embryonic aneuploidy among oncofertility patients compared to the general infertility population | 1 month |
Relative Efficacy of Vitamins D2 and D3 in Adult Humans

Study Overview
=================
Brief Summary
-----------------
Vitamin D2 in chronic dosing will produce less of an elevation of serum 25(OH)D than will the same dose of vitamin D3.

Official Title
-----------------
Vitamin D Status: Relative Efficacy of Vitamins D2 and D3

Conditions
-----------------
Healthy

Intervention / Treatment
-----------------
* Dietary Supplement: vitamin D2
* Dietary Supplement: vitamin D3


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: willingness to withhold supplement use for duration of study willingness to avoid sun exposure for duration of study Exclusion Criteria: vitamin D supplement use conditions that affect vitamin D metabolism by the body

Ages Eligible for Study
-----------------
Minimum Age: 21 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: vitamin D2<br> | Dietary Supplement: vitamin D2<br>* Study Supplement<br>|
| Active Comparator: vitamin D3<br> | Dietary Supplement: vitamin D3<br>* Study Supplement<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| AUC for increment in serum 25(OH)D |  | 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change in vitamin D content of subcutaneous fat |  | 12 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
vitamin D2, vitamin D3, ergocalciferol, cholecalciferol, vitamin D status, To determine relative potency of vitamins D2 and D3 under conditions of continuous administration, To determine change in vitamin D content of subcutaneous fat after 12 weeks' administration
ActiPatch Plantar Fasciitis Clinical Trial

Study Overview
=================
Brief Summary
-----------------
Plantar fasciopathy is a chronic condition affecting both sedentary populations, individuals in the workplace who must stand for prolonged periods of time, and athletes. It can be disabling. There is no single accepted treatment course that is recommended in the literature. The use of pulsed radio-frequency electromagnetic (PRFE) devices has been proposed as a treatment option in chronic soft-tissue injury due to its ability to reduce pain and inflammation. The proposed study will investigate the efficacy of the use of a PRFE device for the treatment of chronic heel pain using a double blind randomized placebo controlled design study.

Official Title
-----------------
Continuous Low Energy Pulsed Radio Frequency Electromagnetic Field Therapy for the Treatment of Plantar Fasciopathy

Conditions
-----------------
Plantar Fasciitis, Plantar Fasciopathy

Intervention / Treatment
-----------------
* Device: Sham pulsed radio-frequency electromagnetic device
* Device: ActiPatch PRFE Device


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All patients with diagnosis of plantar fasciitis agreeing to participate Over 18 years old Able to wear unit and keep data up-to-date records of use Agree to forgo additional treatments during the study period Exclusion Criteria: Patients who have refused, are unable to give or have withdrawn consent Patients with heel pain present less than 3 months

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Control<br>Sham device that resembles the Actipatch PRFE device, including the light that illuminates when active, but the transmitting function has been disabled. | Device: Sham pulsed radio-frequency electromagnetic device<br>* Disabled PRFE device<br>|
| Experimental: Actipatch<br>Use of the Actipatch PRFE device that is integrated into a viscoelastic heel pad for the treatment of plantar fasciopathy | Device: ActiPatch PRFE Device<br>* Actipatch PRFE device<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Visual Analog Scale (VAS) for pain |  | 4 Weeks Follow-up | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Visual analog scale for pain |  | 26 weeks | 
| Foot and ankle disability index |  | 26 weeks | 
| Tegner activity scale |  | 26 weeks |
THE EFFECT OF ACUPUNCTURE ON THE BLOOD LACTIC ACID LEVELS

Study Overview
=================
Brief Summary
-----------------
Background: In sports, recovery after exercise is a very important process for athletes. Several studies have shown that the rate of disease associated with athlete's recovery can be increased by several modalities, one of which is acupuncture. Objectives: The purpose of this study was to see how the effect of press tack needle acupuncture in reducing blood lactic acid levels after exercise in sports students. Methods: The study design was a randomized controlled clinical trial. Twenty-four sport students were divided into two groups: the acupuncture group (n = 12) and the normal group (n = 12). Press tack needle was attached on PC6 Neiguan and ST36 Zusanli 30 minutes before doing high-intensity exercise. Measurement of lactic acid levels was carried out at 5 minutes and 30 minutes after exercise.

Official Title
-----------------
THE EFFECT OF PRESS TACK NEEDLE ACUPUNCTURE ON THE REDUCTION OF POST-EXERCISE BLOOD LACTIC ACID LEVELS IN SPORT STUDENTS

Conditions
-----------------
Post-exercise Sport Students

Intervention / Treatment
-----------------
* Device: Press tack needle acupuncture


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: willingness to fill out an informed consent form; age between 18-25 years; male; has a BMI value of 18.5-22.9 kg/m2; there is no history of injury or history of surgery on the lower extremities in the last three months; the individual is in good health. Exclusion Criteria: absence or refusal to be examined and not cooperative.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 25 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Press tack needle acupuncture<br> | Device: Press tack needle acupuncture<br>* Pyonex press tack needle sized 0.20x1.2mm<br>|
| No Intervention: Control<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Lactic acid levels | Mean difference of lactic acid levels between two groups | 5-minute after physical exercise and 30-minute after physical exercise | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Heart rate | Mean difference of heart rate between two group | 0-minute after physical exercise and 30-minute after physical exercise | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
lactic acid levels, acupuncture, post-exercise recovery, press tack needle
Next Day Growth Hormone Predicting Pituitary Function After Adenomectomy

Study Overview
=================
Brief Summary
-----------------
This study tried to highlight the predictive value of the morning postoperative cortisol levels, which can act as the prognosis value of the postoperative pituitary function, providing future medication advices for improving patients' safety of drugs.

Detailed Description
-----------------
Transsphenoidal adenomectomy usually accompanied by the failure or recovery of the pituitary gland, which usually causing further hypopituitarism and hormone recovery. In order to prevent the potential applications of adrenal cortical malfunction after the surgery, many medical centers will use glucocorticoid supplements during the perioperative period care. However, this treatment might expose the normal hypothalamic-pituitary-adrenal (HPA) axis function patients into potential threats after the treatment of glucocorticoid supplements, such as bone loss, hypertension, emotional distress, and weight gain. To avoid unnecessary supply of glucocorticoids, the key question is to monitor the pituitary function. Thus, in this study we try to predict the morning postoperative cortisol levels, for further prediction of the postoperative pituitary function. To do so, we will review the retrospective charts of transsphenoidal adenomectomied patients from January, 2013 to April, 2018 in the NTUH Taipei. Use statistical methods analyzing all sorts of medical reports, including perioperative hormone thresholds.This study tried to highlight the predictive value of the morning postoperative cortisol levels, which can act as the prognosis value of the postoperative pituitary function, providing future medication advices for improving patients' safety of drugs.

Official Title
-----------------
Next Day Early Morning Growth Hormone as Predictor of Pituitary Function After Transsphenoidal Adenomectomy

Conditions
-----------------
Hypopituitarism

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion: Patients who had been treated with TSA were enrolled. Exclusion: Hypopituitarism preoperatively. Acromegaly Multiple operations Incomplete hormone data or loss of follow-up

Ages Eligible for Study
-----------------
Minimum Age: 20 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Next Day Early Morning Growth Hormone as Predictor of Pituitary Function After Transsphenoidal Adenomectomy | To predict the morning postoperative cortisol levels, for further prediction of the postoperative pituitary function. | 2 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Hypopituitarism,Pituitary function
Evaluation of the Influence of Output on Skin Covered by Adhesives

Study Overview
=================
Brief Summary
-----------------
This study investigates the impact real output has on peristomal skin covered by an adhesive

Conditions
-----------------
Ileostomy - Stoma

Intervention / Treatment
-----------------
* Other: Standard adhesive strip
* Other: Experimental adhesive strip


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Have given written informed consent Be at least 18 years of age and have full legal capacity Have had an ileostomy for more than one year Have intact skin on the area used in the evaluation Has an ileostomy with a diameter up to (≤) 35 mm Have a peristomal area accessible for application of patches/adhesive strips (assessed by investigating scientist) Exclusion Criteria: Currently receiving or have within the past 2 month received radio- and/or chemotherapy Currently receiving or have within the past month received topical steroid treatment in the peristomal skin area or systemic steroid (tablet/injection) treatment. Are pregnant or breastfeeding Having dermatological problems in the peristomal- or abdominal area (assessed by investigating scientist) Participating in other interventional clinical investigations or have previously participated in this evaluation

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Cohort 5<br>This is a sub-study testing the effect of real output applied under two adhesive strips on the skin after 8 hours. There is one visit: Two adhesive strips (standard adhesive strip and Experimental adhesive strip)are applied on the peristomal skin and allowed to sit for 8hours before being removed. | Other: Standard adhesive strip<br>* This is a standard adhesive strip (hydrocolloid)<br>Other: Experimental adhesive strip<br>* This is a strip of a newly developed adhesive.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Trans epidermal water loss | The skins barrier function is measured using trans epidermal water loss after removing the adhesive from the skin | 4 - 24 hours |
Pain Perception at Laser Treatment

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to compare the pain perception at laser treatment of peripheral retinal degenerations with green and infrared wavelengths.

Detailed Description
-----------------
Purpose: To compare the pain perception at laser treatment of peripheral retinal degenerations with green and infrared wavelengths. Methods: Thirty patients (60 eyes) were enrolled in the study. Each patient had one eye treated with infrared laser (diode, 810nm) and the other eye treated with green laser (frequency-doubled solid state laser, diode-pumped, with 532-nm). The laser treatment was performed following a standardized protocol. Immediately after photocoagulation, the patient was asked to grading pain perception according an 11-point (i.e. 0-10) numerical rating scale (NRS) 2,3, accompanied by the instructions Please rate your pain by indicating the number that best describes it. This NRS is represented as a straight line (10 cm in length). The numbers between 0 and 10 are spaced at regular intervals along the line, at either end of the line are two poles that are defined as the extreme limits of the response to be measure, with '0' meaning 'No pain' and '10' meaning 'Pain as bad as you can imagine'.

Official Title
-----------------
Pain Perception at Laser Treatment of Peripheral Retinal Degenerations With Green and Infrared Wavelengths

Conditions
-----------------
Laser Therapy, Low-Level

Intervention / Treatment
-----------------
* Procedure: retina photocoagulation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: horseshoe tears and dialyses, besides operculated holes and lattice degeneration in symptomatic patients (photopsias) or with history of retinal disease Exclusion Criteria: severe liver disease, pregnancy, patients on regular analgesics, previous laser photocoagulation, and age less than 18 years old.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: retina photocoagulation|Each patient had one eye treated with infrared laser (diode, 810nm wavelength) and the other eye treated with green laser (frequency-doubled solid state laser, diode-pumped, with 532-nm wavelength|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Although the treatment of peripheral retinal degenerations with infrared laser to be well tolerated by the majority of the patients, it is more painful than with green wavelength. |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
lasers, pain measurement, photocoagulation, retina
Anxiety/Depression, Sleep and Alcohol in Elderly Anxiety/Depression, Sleep Disturbances and Alcohol Use Disorder in Elderly With Cognitive Complaints

Study Overview
=================
Brief Summary
-----------------
The goal of MEM-ASA is to investigate the prevalence of anxiety/depression, sleep disturbances and alcohol use disorder in elderly with cognitive complaints. In memory clinics of Normandy (France), all patients aged over 50 year-old are systematically questioned about anxiety, depression, sleep quality and alcohol use disorder. They also perform a neuropsychological assessment. Questionnaires are given to the patient and his/her caregiver to be filled in at home. Levels of anxiety/depression, sleep quality and alcohol consumption are related to neuropsychological performance, diagnosis and responses to the questionaires.

Official Title
-----------------
Prevalence of Anxiety/Depression, Sleep Disturbances and Alcohol Use Disorder in Elderly With Cognitive Complaints

Conditions
-----------------
Anxiety State, Sleep Disturbance, Alcohol Abuse, Aging, Dementia

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: To have cognitive complaints To have french as native language Not to be opposed to be included To be affiliated to the social security Exclusion Criteria: -To be under tutorship or curatorship

Ages Eligible for Study
-----------------
Minimum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Anxiety and depression | Responses to questions during anamnesis | At inclusion | 
| Sleep quality | Responses to questions during anamnesis | At inclusion | 
| Alcohol use disorder | Responses to questions during anamnesis | At inclusion |
A Study To Evaluate The Safety And Efficacy Of An Investigational Diabetes Drug In Poorly Controlled Type II Diabetics

Study Overview
=================
Brief Summary
-----------------
The purpose of this research study is to determine if a new investigational diabetes drug is safe and effective in treating people who have Type II diabetes mellitus with very high HbA1c or FPG (fasting plasma glucose) levels. The HbA1c test, also called the hemoglobin A1c test or glycated hemoglobin test, is a measurement of the average amount of sugar in the blood over the last 2 to 3 months. FPG is a test that measures the amount of sugar in the blood after an 8 hour fast.

Official Title
-----------------
An Open-label Trial to Evaluate the Safety and Efficacy of Fixed Dose Rosiglitazone/Metformin Combination Therapy in Poorly-controlled Subjects With Type 2 Diabetes Mellitus

Conditions
-----------------
Diabetes Mellitus, Type 2

Intervention / Treatment
-----------------
* Drug: rosiglitazone/metformin


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Laboratory result for HbA1c >11% or FPG >270mg/dL Clinical diagnosis of Type II diabetes Prior treatment with diet and/or exercise alone, or less than 15 days of prior treatment with an oral anti-diabetic medication or insulin. Exclusion Criteria: Women who are pregnant

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: rosiglitazone/metformin|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hemoglobin A1c (HbA1c) reduction after 24 weeks of treatment. |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in FPG, insulin,C-peptide, insulin sensitivity,beta cell function, free fatty acids, lipids. Change in weight, vital signs, clinical laboratory tests, and adverse experiences. |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Hyperglycemia, HbA1c, Hemoglobin A1c, Type 2 diabetes mellitus