MDD(Mild Cognitive Impairment Delirium Dementia) Cohort

Study Overview
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Brief Summary
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Identify the degree of delirium in subjects with mild cognitive impairment and find the risk factors of delirium. Mortality, hospital stay, and medical expenses are analyzed as clinical consequences related to delirium incidence. Dementia conversion rate and conversion period of subjects with mild cognitive impairment with delirium and it identifies the effect of delirium on dementia conversion. Develop an AI(Artificial intelligence) algorithm for predicting dementia transition in subjects with mild cognitive impairment based on the research results of the 1st, 2nd, and 3rd years.

Official Title
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A Prospective, Longitudinal Cohort Study of the Incidence of Dementia After the Onset of Delirium in Patients With Mild Cognitive Impairment: MDD Cohort (Mild Cognitive Impairment Delirium Dementia)

Conditions
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Delirium, Mild Cognitive Impairment, Dementia

Intervention / Treatment
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* Diagnostic Test: Delirium assessment using S-CAM


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients 65 years of age or older who are admitted to a LTC Patients diagnosed with mild cognitive impairment by doctors Patients with a score of 18 or more and 23 or less on the Mini-Mental State Examination Exclusion Criteria: Patients unable to measure the delirium assessment tool, The Short Confusion Assessment Methods (S-CAM) (Inouye, 2014) due to severe vision and hearing problems Patients with serious psychiatric or neurological diagnosis,Patients who expire or were transferred on the day of admission - Patients receiving emergency treatment at the time of the delirium assessment or unable to measure or intervene with S-CAM due to hospital circumstances

Ages Eligible for Study
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Minimum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| MCI(Mild Cognitive Impairment) group<br>Inclusion criteria : Patients 65 years of age or older who are admitted to a LTC(long-term care) facilities, Patients diagnosed with mild cognitive impairment by doctors, Patients with a score of 18 or more and 23 or less on the Mini-Mental State Examination Exclusion criteria : Patients unable to measure the delirium assessment tool, The Short Confusion Assessment Methods (S-CAM) (Inouye, 2014) due to severe vision and hearing problems, Patients with serious psychiatric or neurological diagnosis,Patients who died or were transferred on the day of admission, Patients receiving emergency treatment at the time of the delirium assessment or unable to measure or intervene with S-CAM due to hospital circumstances | Diagnostic Test: Delirium assessment using S-CAM<br>* Twice a day, the rounds of nurses in shifts, 8:00 am - 10:00 am, 4:00 pm - 6:00 pm Trained research assistants assessed delirium using S-CAM<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Delirium incidence in participants with mild cognitive impairment | descriptive statistics | The number of subjects evaluated as positive in the delirium assessment using S-CAM for 30 days from the 1st day of study participation is statistically calculated. | 
| Dementia conversion rate and transition period in participants with mild cognitive impairment | descriptive statistics | The participant's dementia conversion is checked in units of 1 month, and the period until conversion to dementia is analyzed in units of 12 months for 36 months. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Risk factors affecting participants' delirium | Logistic Regression | On the first day of data collection, the characteristics of subjects are collected through medical records. After 12 months, the risk factors affecting the occurrence of delirium among the characteristics of the subject are analyzed. | 
| Mortality | Kaplan-Meier survival, Cox proportional hazard regression, Logistic Regression | It is statistically calculated in 30-day, 60-day, 12-month, 24-month, and 36-month increments. | 
| hospital length of stay | Linear Regression | The period from hospitalization to discharge is calculated in days and analyzed in units of 12 months. | 
| healthcare costs | Linear Regression | From the healthcare costs consumed during the hospital length of stay, the direct healthcare costs used only for treatment are calculated in won units and analyzed in units of 12 months. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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delirium, mild cognitive impairment, dementia