Effect of Computer-based Cognitive Training on Attention and Executive Functions in Patients With Parkinson's Disease

Study Overview
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Brief Summary
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The current study adresses the effect of two different computer-based cognitive trianing programmes on attention and executive functions in patients with Parkinson's disease.

Detailed Description
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The current study adresses the effect of two different computer-based cognitive training programmes (Brain+ Evolution and Scientific Brain Training PRO) on attention and executive functions in patients with Parkinson's disease. The patients are assigned to one of three groups. Two training groups with each their programme, and a control Group. The training groups will train at home for 8 weeks with follow-ups every second week. The control group will not train at home, but will also receive a follow-up with computer-based stimuli (computerized Card game) every second week, to minimize the possibility that a possible effect is due to the follow-up's with a professional, and not due to the computer training at home.

Official Title
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The Effect of Computer-based Cognitive Training on Attention and Executive Functions in Patients With Parkinson's Disease

Conditions
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Parkinson Disease, Executive Dysfunction

Intervention / Treatment
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* Device: Computer-based cognitive training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with Parkinson's disease AND Montreal cognitive assesment (MOCA)-score between 22-28 Motorically cabable of using an iPad Not receiving antipsychotic medicine No comorbid diseases which might influence the level of executive functioning, for an example ADHD or acquired brain damage Exclusion Criteria: People without Parkinson's disease Parkinson's patients not included in the above inclusion criteria
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Two intervention Groups training with each their computer-based cognitive programme, one control Group receiving no intervention except for the same amount of follow-ups as the two intervention Groups.
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Brain+ Evolution<br>Intervention: Training with computer-based programme Brain+ Evolution for 8 weeks, receiving follow-ups every second week. Computer-based cognitive training. | Device: Computer-based cognitive training<br>* Computer-based cognitive programmes are computer programmes designed as games with the aim of training patients in certain cognitive domains.<br>|
| Experimental: Scientific Brain Training PRO<br>Intervention: Training with computer-based programme Scientific Brain Training PRO for 8 weeks, receiving follow-ups every second week. Computer-based cognitive training. | Device: Computer-based cognitive training<br>* Computer-based cognitive programmes are computer programmes designed as games with the aim of training patients in certain cognitive domains.<br>|
| No Intervention: Control group<br>This Group receives no intervention except for the same amount of follow-ups as the two training Groups. This is done to ensure that an effect of training is not aqtually due to the follow-up's with a professional. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| SDMT | Symbol digit modalities test, neuropsychological test of processing speed | 2 minutes | 
| PDQ-39 | Parkinson's disease questionnaire; daily functioning and well-being in Parkinson's disease | 20 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| HADS | Hospital anxiety and depression screening | 10 minutes | 
| Digit span | Digit span Wais-IV; Working memory | 10 minutes | 
| Verbal fluency | S-Words, animal-names and A/F-words | 3 minutes | 
| Stroop colour/word test | Stroop colour/Word test, respone inhibition | 3 minutes | 
| Trail Making A and B | Trail Making A and B, cognitive flexibility | 5 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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parkinson, executive dysfunction, attention, computer-based cognitive training