The Effect of Spironolactone on Pain in Older People With Osteoarthritis

Study Overview
=================
Brief Summary
-----------------
This pilot study will obtain preliminary evidence on which to base sample size calculations for a future trial of whether spironolactone (an aldosterone blocker) reduces knee pain in older people with symptomatic OA knee when given in addition to usual analgesia. Aldosterone is known to be pro-inflammatory, and spironolactone suppresses cytokine production in chronic arthritis. This application builds on previous work by the applicants showing that spironolactone significantly improved quality of life (particularly pain) in frail older people. The investigators will recruit 86 people (aged 70 years or over) with well-defined OA knee to 25mg spironolactone daily or to matching placebo for 12 weeks. The primary outcome is the between group difference in change in WOMAC pain sub-score at 12 weeks. Secondary outcomes are the WOMAC stiffness and physical function subscales and health related quality of life (EQ-5D). Morning cortisol levels will be measured to assess the effect of mineralocorticoid receptor blockade on glucocorticoid levels, which may mediate the anti-inflammatory effect of spironolactone; and urinary CTX-II, and serum matrix metalloproteinase-3 (MMP-3) will be measured as biomarkers as both are sensitive to the effects of pharmacological interventions for osteoarthritis.

Official Title
-----------------
A Randomised Placebo Controlled Trial. The Effect of Spironolactone on Pain in Older People With Osteoarthritis

Conditions
-----------------
Osteoarthritis, Knee

Intervention / Treatment
-----------------
* Drug: spironolactone


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Participant is willing and able to give informed consent Community dwelling Aged 70 years and over Symptomatic idiopathic OA knee according to American College of Rheumatology clinical and radiographic criteria (ie Knee pain - with or without crepitus and presence of osteophytes on x ray) To avoid floor effects, participants will require to have moderate (or more severe) pain at screening in at least 2 out of 5 WOMAC pain score items To have been in receipt (prescription or/and over the counter) of one or more analgesic agents at a therapeutic dose for at least 2 months Willing to have knee x-ray if one has not been taken in preceding 12 months Exclusion Criteria: Clinical diagnosis of symptomatic heart failure History of inflammatory arthritis Already taking spironolactone Previous intolerance to spironolactone Known allergies to spironolactone or lactose Objection to taking capsules made from animal sourced gelatine Taking oral NSAIDs (because of the increased risk of renal impairment when combined with spironolactone) Taking ACE inhibitors or ARBs (angiotensin II receptor antagonists). ARBs have many properties similar to those of ACE inhibitors. Both will be exclusion because of the increased risk of acute kidney injury and hyperkalaemia, and because our previous study also excluded those on ACE inhibitors (and ARBs) and treatment was safe and well tolerated. Supine hypotension (supine systolic blood pressure <100mmHg at screening) Significant chronic kidney disease (eGFR<40ml/min) Serum sodium<130mmol/l Serum potassium>5.0mmol/l Symptomatic orthostatic hypotension (measured at screening) Nursing home resident Wheelchair bound Participating in another clinical trial (other than observational trials and registries) concurrently or within 30 days prior to screening for entry into this study Known contraindication to spironolactone therapy Participant who is terminally ill, defined as less than 3 months expected survival

Ages Eligible for Study
-----------------
Minimum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: spironolactone<br>25mg spironolactone daily | Drug: spironolactone<br>* spironolactone 25mg daily for 12 weeks<br>* Other names: Aldactone;|
| Placebo Comparator: Placebo<br>Matched Placebo | Drug: spironolactone<br>* spironolactone 25mg daily for 12 weeks<br>* Other names: Aldactone;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Between group difference in change in WOMAC pain subscale (5 items) |  | 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Between group difference in change in WOMAC stiffness subscale. |  | 12 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Osteoarthritis of knee