Feasibility of Strength Training in Patients Hospitalized Due to COPD

Study Overview
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Brief Summary
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To examine the feasibility of progressive unilateral knee-extension strength training using ankle weight cuffs in patients hospitalized due to acute exacerbation in COPD

Detailed Description
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We decided that feasibility is indicated if: 1) the absolute training loads increase progressively, 2) more than 80% of the planned training sessions are completed, and 3)if the absolute training loads do not exceed 20 kg (2 x10kg weight cuffs) for 90% of patients.

Official Title
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Feasibility of Progressive Knee Extension Strength Training Using Ankle Weight Cuffs in Patients Hospitalized With COPD in Acute Exacerbation

Conditions
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COPD, Muscle Weakness

Intervention / Treatment
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* Other: Resistance training in AECOPD


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Have a primary diagnosis of COPD Be admitted to the pulmonary ward due to an exacerbation in COPD Provide informed consent to participation in the study Be able to maintain an upright position on a chair Be able to be guided to training and understand instructions for participating Exclusion Criteria: Patients suffering from diseases that prevents the use of wrist weights such as Deep venous thrombosis (DVT) Erysipelas Painful edema of the limbs Lack of ability to walk, habitually Predicted hospital stay of less than four days as predicted by a pulmonary physician Patients admitted Friday night or Saturday morning cannot be stared up within 24 hours of admittance
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Resistance training in AECOPD<br>The patients conduct daily training during admission with weight cuff 3 set of 10 rep. | Other: Resistance training in AECOPD<br>* The patients begin training on day 1 of admittance. The training consists of knee extension performed in the sitting position on the bed with a 90 degrees of flexion of the knees. The weight cuffs are tired to the angles with a weight corresponding to 10 RM (the weight lifted 10 times). The weights and exercises are subjected to supervision on daily basis by the physiotherapist. The weight is increased after every set of training if more than 10 rep. can be performed with a given weight. Limitations to exercise is also recorded along with the degree of dyspnoea as assessed by the Borg CR10, possible oxygen supplementation and saturation is recorded before and following exercise.<br>* Other names: hospitalization;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Increase of training load during admission | Change in training loads measured by the number of kilos lifted using ankle weight cuffs in 3 sets of 10 repetition maximum at the first training day to the number of kilos lifted at the last training day | The patients will be followed for the duration of hospital stay, an expected average of 6 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Maximal isometric knee extension strength | Maximal isometric knee extension strength is measured unilaterally by a fixated handheld dynamometer. The test will be performed upon admission and at the day of discharge | The patients will be followed for the duration of hospital stay, an expected average of 6 days | 
| Sit-to- stand- test | The number of times the patient comes to full standing position in 30 seconds. The Sit to Stand test provides a measurement of a person's lower body (particularly quadriceps) strength. This is associated with the ability to perform lifestyle tasks such as climbing stairs, getting in and out of a vehicle or bath. The test will be performed upon admission and on the day of discharge | The patients will be followed for the duration of hospital stay, an expected average of 6 days | 
| Timed Up and Go (TUG) | A test used to assess a person's mobility and requires both static and dynamic balance. The time that a person takes to rise from a chair, walk three metres, turn around, walk back to the chair, and sit Down. The test will be performed at admission and at the day of discharge | The patients will be followed for the duration of hospital stay, an expected average of 6 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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COPD acute exacerbation, Physiotherapy, Resistance training, Muscle strength, Handheld dynamometer