Identify Clinical Conditions That Increase Circulating DNA Levels

Study Overview
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Brief Summary
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The investigators are developing a test that is expected to measure the amount of radiation a patient has been exposed to after a nuclear bomb. The investigator will do this by measuring the DNA in the patients blood from cells killed by the radiation. Many diseases and medical conditions can put DNA in the blood. The investigator needs to know how much DNA in order to better interpret our radiation detection test. Therefore, the investigator is collecting blood from several patients with different diseases or medical conditions and also healthy volunteers to measure their DNA content. Patients that will be included in this study are pregnant women, patients who have suffered a pulmonary embolism within the past 48 hours, patients who have suffered from myocardial infarction in the past 48 hours, patients with autoimmune diseases and health patients.

Detailed Description
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The investigator will collect 8 mL (one and one half teaspoons) of blood one time only. The investigator may also collect the patient's past medical history, test results and disease treatment.

Official Title
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Identify Clinical Conditions That Increase Circulating DNA Levels

Conditions
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Pregnancy, Pulmonary Embolism, Myocardial Infarction, Autoimmune Disease

Intervention / Treatment
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* Other: One time blood draw to look at patient's DNA


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients must be adults in one of the following categories: Pregnant Suffered a pulmonary embolism within the past 48 hours Myocardial infarction in the past 48 hours Diagnosed with an autoimmune disease Adults age 18-80 Self-declared healthy adults Patients must be willing to undergo a blood draw Patients must provide study-specific informed consent prior to study entry Exclusion Criteria: 1. Patients not meeting the above inclusion criteria

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Pregnant Women<br>Females between the age of 18-80 who are pregnant One time blood draw to look at patient's DNA | Other: One time blood draw to look at patient's DNA<br>* One time blood draw to look at patient's DNA<br>|
| Pulmonary Embolism Patients<br>Male and Female patients that have suffered a pulmonary embolism within the past 48 hours One time blood draw to look at patient's DNA | Other: One time blood draw to look at patient's DNA<br>* One time blood draw to look at patient's DNA<br>|
| Myocardial Patients<br>Male and Female patients who have myocardial infarction in the past 48 hours. One time blood draw to look at patient's DNA | Other: One time blood draw to look at patient's DNA<br>* One time blood draw to look at patient's DNA<br>|
| Autoimmune Patients<br>Male and Female patients that have been diagnosed with an Autoimmune disease One time blood draw to look at patient's DNA | Other: One time blood draw to look at patient's DNA<br>* One time blood draw to look at patient's DNA<br>|
| Healthy Controls<br>Self-declared healthy adults (men and women). One time blood draw to look at patient's DNA | Other: One time blood draw to look at patient's DNA<br>* One time blood draw to look at patient's DNA<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Different diseases will be analysed for the levels of DNA circulating in the blood | To determine what medical conditions and disease states might increase circulating DNA levels at a magnitude similar to whole body irradiation. | blood will be tested up to 1 year after collection | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Pregnancy, pulmonary embolism, myocardial infarction, autoimmune disease, healthy controls