The Effect of Calcium on Fecal Fat and Energy Excretion

Study Overview
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Brief Summary
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The overall purpose of this study is to examine the effect of calcium on fecal fat and energy excretion.

Detailed Description
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Several reports have found inverse associations between calcium intake and body weight. Few intervention studies have shown that a high calcium diet resulted in a greater body weight loss than a low calcium diet. The mechanism is not clear, but one possible explanation is reduced absorption of fat in the gut, due to formation of insoluble calcium fatty acid soaps or binding of bile acids which impairs the formation of micelles. The aim of this study is to examined if a high calcium intake from dairy products, in diets high or normal in fat content, have an effect on fecal energy and fat excretion, concentrations of substrates involved in energy metabolism and blood pressure.

Conditions
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Obesity

Intervention / Treatment
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* Other: Dairy calcium


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: healthy meals BMI 24-31 kg/m2 age between 18-50 years Exclusion Criteria: donation of blood 6 months before and under the study milk allergy, diabetes, hypertension, hyperlipidemia, cronic infectious disease use of dietary supplements 3 months before and under the study smoking elite athletes use of medication

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: 1<br>Diet with high content of calcium and high content of fat | Other: Dairy calcium<br>* Diets with different content of calcium and fat<br>|
| Other: 2<br>Diet with low content of calcium and high content of fat | Other: Dairy calcium<br>* Diets with different content of calcium and fat<br>|
| Other: 3<br>Diet with high content of calcium and normal content of fat | Other: Dairy calcium<br>* Diets with different content of calcium and fat<br>|
| Other: 4<br>Diet with low content of calcium and normal content of fat | Other: Dairy calcium<br>* Diets with different content of calcium and fat<br>|
| Other: 5<br>Diet with high content of calcium fra supplement and high content of fat | Other: Dairy calcium<br>* Diets with different content of calcium and fat<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fecal fat excretion, fecal energy excretion, calcium excretion, cholesterol |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Vitamin D, changes in lipolyse |  |  | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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dairy products, calcium, fat excretion, energy excretion