Gingival Crevicular Fluid and Placental Tissue Levels of Interleukin-17 as a Possible Marker for Preterm Labor in Patients With Chronic Periodontitis

Study Overview
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Brief Summary
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This case control-study measures the levels of Interleukin-17 in gingival crevicular fluid and placental tissue samples of pregnant females as a possible marker in determining whether or not an association exists between chronic periodontitis and preterm labor. Interleukin-17 is a pro-inflammatory cytokine whose levels have been proven to increase in periodontal disease.

Official Title
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Gingival Crevicular Fluid and Placental Tissue Levels of Interleukin-17 as a Possible Marker for Preterm Labor in Patients With Chronic Periodontitis

Conditions
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Preterm Labor, Chronic Periodontitis

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Within the age range of 18-35 years Free of any systemic diseases as referenced from Burket's Oral Medicine health history questionnaire (Glick2008) Spontaneous normal term birth at ≥37 weeks of gestation without any obstetrical or medical complications Spontaneous preterm birth (PTB) at <37 weeks of gestation after uterine contraction or rupture of membranes (Keelan1999) Exclusion Criteria: History of medications that may affect the study outcome, such as: current use of systemic corticosteroids or antibiotics for at least one month Genital and urinary tract infections Existing hypertension and diabetes mellitus before pregnancy, autoimmune disease, asthma, and chronic renal disease Multiple pregnancies, cervical cerculage, abnormal placentation, past history of preterm delivery, or antepartum hemorrhage Low or high maternal body mass index

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Preterm/Chronic Periodontitis<br>Included ten female patients who underwent spontaneous preterm birth and were diagnosed with chronic periodontitis upon clinical examination | |
| Preterm/Healthy Periodontium<br>Included ten female patients who underwent spontaneous preterm birth and who had a healthy periodontium upon clinical examination | |
| Term/Chronic Periodontitis<br>Included ten female patients who underwent spontaneous normal term birth and were diagnosed with chronic periodontitis upon clinical examination | |
| Term/Healthy Periodontium<br>Included ten female patients who underwent spontaneous normal term birth and who had a healthy periodontium upon clinical examination (Armitage1999) | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Interleukin-17 | Interleukin-17 levels in gingival crevicular fluid and placental tissue samples | Single sample from each patient following birth | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Chronic Periodontitis, Preterm Labor, Preterm Birth, Interleukin-17, IL-17, Periodontal Disease, Periodontitis, Periodontal risk factors, Medical risk factors