Predicting Complications of Hepatolithiasis After Hepatectomy

Study Overview
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Brief Summary
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Postoperative complications seriously affect the recovery of patients undergoing hepatectomy. Identifying risk factors and develop predictive models of complications for patients with hepatolithiasis undergoing hepatectomy is important for clinical practice.

Detailed Description
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Along with the change of lifestyle and dietary habits, many people are diagnosed with hepatolithiasis that is especially prevalent in Asia. Liver resection remains the favorable curative therapy for hepatolithiasis with a relatively low recurrence rate. Although there have been great improvements in surgical techniques and perioperative management, postoperative complications remain commonplace and seriously threat the recovery of patients undergoing hepatectomy. Therefore, it is important to identify risk factors of complications to improve the overall prognosis of patients. We want to collect the clinical information of patients with hepatolithiasis undergoing hepatectomy, including demographic data , laboratory index, histological features and postoperative complications. Patients are followed up at a interval of 3 month after treatment, and the survival data and recurrence rate are recorded. Then the relationship between clinical data and short-term outcomes after surgery are explored. Then models based on clinical features are developed to predict short-term outcomes after hepatectomy.

Official Title
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Machine Learning Algorithms Based on Clinical Data to Predict Postoperative Complications of Patients With Hepatolithiasis Undergoing Hepatectomy

Conditions
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Liver Diseases, Complication

Intervention / Treatment
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* Diagnostic Test: radiological evaluation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: pathologically diagnosed hepatolithiasis without malignancies receiving liver resection Eastern Cooperative Oncology Group performance status (ECOG-PS) 0-2 Child-Pugh score of ≤7 complete clinical and follow-up information age between 18-80 years old Exclusion Criteria: with malignancies receiving other treatments Eastern Cooperative Oncology Group performance status (ECOG-PS) >2 Child-Pugh score of >7 incomplete clinical data lost to follow up age <18 years old or >80 years old

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| patients with postoperative complications<br>Patients who experienced postoperative complications were divided into the first group. The complications were defined according to the Clavien-Dindo classification system. | Diagnostic Test: radiological evaluation<br>* All patients undergoing hepatectomy receive imaging evaluation and laboratory test before and after surgery to define clinical parameters. diseases<br>|
| patients without postoperative complications<br>Patients who didn't experience postoperative complications were divided into the second group. | Diagnostic Test: radiological evaluation<br>* All patients undergoing hepatectomy receive imaging evaluation and laboratory test before and after surgery to define clinical parameters. diseases<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Complications | Postoperative complications and mortality are recorded according to the Clavien-Dindo classification system | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Recurrence of hepatolithiasis | Patients were followed-up at an interval of 3 months and recurrence of hepatolithiasis is evaluated by radiological methods. | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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liver resection, complication, risk factor, machine learning, hepatolithiasis