L-PRF in Alveolar Ridge Preservation

Study Overview
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Brief Summary
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The effect of leucocyte- and platelet-rich fibrin (L-PRF) for enhancing the healing after dental extractions is still a matter of debate. The available literature suggests that L-PRF performs positive effect to improve alveolar preservation resulting in less bone resorption on extraction sockets. L-PRF is a second generation of platelet concentrate produced without biochemical blood manipulation. L-PRF is composed by three key parameters: first, the presence of platelets; second, the presence of leucocytes; third, the density and complex organization of the fibrin matrix architecture produced by a natural polymerization process. The theory is that this key parameters acts to produce a faster bone healing.

Official Title
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Tomographic and Histological Evaluation of Postextraction Sockets Treated With Leucocyte- and Platelet-rich Fibrin: a Randomized Clinical Trial

Conditions
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Bone Loss, Alveolar

Intervention / Treatment
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* Procedure: Platelet-rich fibrin


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: (1) Health patients, American Society of Anesthesiologists (ASA) I or II (2) Patients who need to submit tooth extraction (pre-molar, canine and incisor teeth - uniradicular teeth or teeth with fused roots) which present ideal conditions to receive dental implants after 3 months. Exclusion Criteria: Smoking Systemic diseases related with healing disorders Poor oral hygiene Pregnant or lactating patient Use of flap elevation for dental extraction

Ages Eligible for Study
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Minimum Age: 17 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: L-PRF group<br>The use of autologous leucocyte- and platelet-rich fibrin in alveolar sockets after dental extraction. | Procedure: Platelet-rich fibrin<br>* The use of autologous platelet-rich fibrin after tooth extraction to promote bone healing and alveolar ridge preservation<br>* Other names: platelet concentrate;|
| No Intervention: Control<br>Conventional tooth extraction without any bone substitute. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Width resorption 1mm | The ridge width differences between baseline and after three months of healing 1 mm below the crest. | After 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Width resorption 3mm | The ridge width differences between baseline and after three months of healing 3 mm below the crest. | After 3 months | 
| Width resorption 5mm | The ridge width differences between baseline and after three months of healing 5 mm below the crest. | After 3 months | 
| Histological Analysis - fibrous tissue | The percentage of soft (fibrous) tissue | After 3 months | 
| Histological Analysis - bone cells | Quantity of bone cells (osteoblast, osteoclast and osteocyte) | After 3 months | 
| Histological Analysis - capillary vessels | Quantity of capillary vessels | After 3 months | 
| Histological Analysis - new bone formation | The percentage of the newly formed bone | After 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Platelet-rich fibrin, Tooth Extraction, Alveolar Bone Grafting