Long-term Consequences of Neuroimaging and Perceived Cognitive Dysfunction in oPRES

Study Overview
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Brief Summary
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The purpose of this study is to explore the long-term consequences of neuroimaging and perceived cognitive dysfunction in obstetrics posterior reversible encephalopathy syndrome.

Detailed Description
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This is a prospective study. The investigators divided the PE or E patients into two groups, namely PRES group and non-PRES group, according to diagnostic criteria . The general information（demographic data，blood pressure.etc.）and blood sample will be collected. Additionally,all patients receive neuroimaging examination（DTI,ASL,3D-TMI.etc.）and neuro-cognitive test（MMSE,MOCA,CFQ, etc.） to assess the cerebral white matter lesions and cognitive changes.

Official Title
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Long-term Consequences of Neuroimaging and Perceived Cognitive Dysfunction in Obstetrics Posterior Reversible Encephalopathy Syndrome

Conditions
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Neuroimaging, Cognitive Dysfunction, Posterior Reversible Encephalopathy Syndrome

Intervention / Treatment
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* Biological: neuroimaging examination,neuro-cognitive test,blood pressure,blood sample


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients were diagnosed of PE or E patients received cranial image examination patients consent to participate Exclusion Criteria: patients combined other neurological diseases patients combined mental illness

Ages Eligible for Study
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Minimum Age: 15 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| PRES group<br>PE or E with PRES | Biological: neuroimaging examination,neuro-cognitive test,blood pressure,blood sample<br>* neuroimaging will be perform,neuro-cognitive will be tested,blood pressure will be monitored,blood samples will be tested<br>|
| non-PRES group<br>PE or E without PRES | Biological: neuroimaging examination,neuro-cognitive test,blood pressure,blood sample<br>* neuroimaging will be perform,neuro-cognitive will be tested,blood pressure will be monitored,blood samples will be tested<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| neuroimaging examination | the degree of white matter lesions(0,normal; 1, limited cortical or subcortical white matter oedema; 2, white matter oedema > cortical oedema, white matter oedema extending into deep white matter; 3, white matter oedema > cortex oedema, oedema extending to the ventricular surface; 4, the involved regions substantially extend to the ventricular surface and are almost completely conﬂuent; 5, involved regions are fully conﬂuent and continuous, ventricular deformity due to the oedema).The value of fractional anisotropy(FA) in PRES group may higher than non- PRES group, and mean diffusivity (MD) in PRES group may lower than non- PRES group. | within 10 years after deliver | 
| neuro-cognitive test of Mini-mental State Examination | the scores of Mini-mental State Examination,normal (27-30);mild (21-26); moderate (10-20); severe (0-9). | within 10 years after deliver | 
| neuro-cognitive test of Montreal Cognitive Assessment | the scores of Montreal Cognitive Assessment,normal (≥26); abnormal (<26). | within 10 years after deliver | 
| blood pressure and hypertension | Hypertension: blood pressure ≥140/90 mmHg | within 10 years after deliver | 
| level of lactate dehydrogenase(LDH) | inflammatory: LDH>380U/L | within 10 years after deliver | 
| level of LDL in blood | hyperlipidemia：LDL>3.12mmol/L | within 10 years after deliver |