Early Identification of Patients Presenting a First Psychotic Episode, Non Answering to First Line Support Strategies

Study Overview
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Brief Summary
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Researchers propose in this project to evaluate predictive factors of non response. It is defined by the lack of symptomatic remission at month 3, for patients presenting a first episode of psychosis. It will be performed on objective markers taken from imagery techniques. The link between evolution of these markers and clinical measures will be studied.

Detailed Description
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Recently, radiological markers demonstrated a good capacity to discriminate first episode of psychosis patients, that will show a bad response to treatment. Furthermore, automatic learning methods were recently successfully applied to neurological data, but never for the first episode psychosis patients. These powerful methods are based on multivariate analyses allowing the prediction at an individual stage. The possibility to identify more precisely the population of non-answering patients would allow the adaptation of the support in first attention for these patients, and consequently to perform appropriate cares. Researchers propose in this project to evaluate predictive factors of non response. It is defined by the lack of symptomatic remission at month 3, for patients presenting a first episode of psychosis. It will be performed on objective markers taken from imagery techniques. The link between evolution of these markers and clinical measures will be studied.

Official Title
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Early Identification of Patients Presenting a First Psychotic Episode, Non Answering to First Line Support Strategies: A Multicentric Study

Conditions
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Schizophrenia

Intervention / Treatment
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* Procedure: MRI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: men and women aged 18-35 years member or beneficiary of a social security scheme, for women, appropriate contraception will be mandatory, as well as a negative pregnancy test, patients with a diagnosis of schizophrenia, schizoaffective disorder or schizophreniform disorder according to the DMS V having never received anti-psychotic treatment, followed in the hospital or outpatient, having given their written informed consent, that the physical examination revealed no significant clinical abnormalities Exclusion Criteria: Female patients of childbearing period without effective contraception (oral, intramuscular hormonal, intrauterine device, or surgical); Patients pregnant or nursing; Presenting a serious somatic or neurological disease, especially Parkinson's disease, epilepsy, debilitating tardive dyskinesia, cardiovascular disease, severe liver or kidney; Featuring against-indication for an MRI; including: metallic foreign body eye or intracranial, pacemaker, heart valve, surgical clips, claustrophobia, large tattoo in the upper part of the body, not compatible with 3T MRI Having a history of alcohol or drug abuse in the past year; Participating in another clinical trial or being in an exclusion period of the previous protocol; Patients likely to exhibit aggressive behavior self according to the judgment of the investigators.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| First episode of psychosis patients<br>Patients with schizophrenia will be studied in this clinical trial, and that have never received anti-psychotic treatment. They will perform an MRI. | Procedure: MRI<br>* Magnetic Resonance Imagery will be performed on patients attempted by schizophrenia. The aim of this intervention is an early detection of the non-answering patients to the primary cares.<br>* Other names: Magnetic Resonance Imagery;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Score of the predictive value of the imagery markers. | Evaluate the predictive value for the imagery markers on the therapeutic non-answer at month 3 for patients presenting a first psychotic episode. | Month 3 |