Bogota School Children Cohort

Study Overview
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Brief Summary
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This observational study investigates the associations of nutritional indicators, biomarkers, sociodemographic conditions, and infections with child health, as well as physical, behavioral, and cognitive development. Investigators recruited a random sample of 3202 children from primary public schools in Bogota, Colombia in February 2006 and followed them for a median of 6.5 years. Investigators hypothesized that poor nutritional status at the time of recruitment in middle childhood would be related to adverse health outcomes through adolescence.

Official Title
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Bogota School Children Cohort

Conditions
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Neurocognitive Development, Sexual Maturation, Nutrition, Child Health, Child Growth, Infectious Morbidity, Behavior Problem

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Primary public school enrollment in February 2006 Exclusion Criteria: None

Ages Eligible for Study
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Minimum Age: 5 Years
Maximum Age: 12 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Bogota School Children Cohort<br>Children are classified according to exposure levels of: Micronutrient biomarker indicators: Ferritin Hemoglobin Mean corpuscular volume Zinc Vitamin A Vitamin B12 Folate Vitamin D Serum fatty acids Inflammatory biomarkers: C-reactive protein Diet Socioeconomic status indicators Anthropometric indicators Incidence of infectious morbidity symptoms DNA biomarkers | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Externalizing behavior problems | Adolescent behavior problems were ascertained with the Youth Self Report (YSR) questionnaire. The YSR is a self-administered questionnaire consisting of 112 statements addressing behaviors or feelings that adolescents rate as false, sometimes true, or very/often true. From responses to these questions, an Assessment Data Manager (ADM) software calculates continuous scores for aggressive behavior and rule breaking behavior. The sum of the aggressive and rule breaking behavior subscale scores constitute the total externalizing problems score. | Assessed at one point in time when the children were 11-18 years old. | 
| Internalizing behavior problems | Adolescent behavior problems were ascertained with the Youth Self Report (YSR) questionnaire. The sum of the anxious/depressed, withdrawn/depressed, and somatic complaint subscale scores constitute the total internalizing problems score. | Assessed at one point in time when the children were 11-18 years old. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Behavior problem subscale scores (aggressive behavior, rule breaking behavior, anxious/depressed, withdrawn/depressed, somatic complaints, attention problems, social problems, and thought problems) | Adolescent behavior problems were ascertained with the Youth Self Report (YSR) questionnaire. | Assessed at one point in time when the children were 11-18 years old. |