CT Evaluation of Cardiovascular Risk Markers in Obese Patients

Study Overview
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Brief Summary
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Obesity is a chronic metabolic disorder : it leads to coronary heart disease and early atherosclerosis. Coronary artery calcium measured by CT is known as a robust predictor to predict risk for cardiac events in symptomatic and asymptomatic individuals. Furthermore, recent studies show that other CT risk factor exists, independent of calcium scoring, such as epicardial fat, intrathoracic fat and visceral fat. The aim of this prospective study is to evaluate these new cardiovascular risk markers in obese patients, using standard dose CT and low dose CT with adaptative statistical iterative reconstruction.

Detailed Description
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In this prospective single-center study, obese patients of our clinical nutrition service, hospitalized for nutritional assessement, are included. All unenhanced coroCT examinations are performed on the same 64-Row CT scanner (discovery CT 750 HD scanner, GE Healthcare), using prospective ECG-triggerring. The investigation protocol began with a standard-dose acquisition followed immediately by a low-dose acquisition, recorded over strictly identical segments (identical first and last sections). After these two examinations, estimated dose values are less than the diagnostic scan reference level for a coroCT.

Official Title
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CT Evaluation of Cardiovascular Risk Markers in Obese Patients

Conditions
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Epicardial Fat, Obesity, Cardiovascular Risks Markers, Metabolic Syndrome, Low Dose Computed Tomography

Intervention / Treatment
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* Other: Unenhanced Coro-CT


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: obesity >30 indicated non enhanced coroCT for calcium scoring. Exclusion Criteria: <18 ans low Framingham scoring pregnancy not providing informed consent history of cardiovascular disease.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| obese patients<br>obese patients of our clinical nutrition service, hospitalized for nutrional assessement, are included. | Other: Unenhanced Coro-CT<br>* All unenhanced coroCT examinations are performed on the same 64-Row CT scanner (discovery CT 750 HD scanner, GE Helthcare), using prospective ECG-triggerring.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Epicardial fat evaluation in obese population |  | at day 1 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Calcium scoring evaluation |  | at day 1 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Epicardial fat, Obesity, Cardiovascular risks markers, Metabolic syndrome, Low dose computed tomography