Clinical and Neurophysiological Evolutions Through a Functional Rehabilitation of Social Communication in ASD

Study Overview
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Brief Summary
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This study aims to identify clinical and biological markers which would allow to evaluate precisely the evolution of children with autism spectrum disorders throughout intervention.

Detailed Description
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200 children with autism spectrum disorders (1-12 years old) will be included in a 2 years follow-up study. Both clinical and neurophysiological evaluations (electrophysiological and eye tracking) will be completed at different times of the follow-up. This integrative approach, combining clinical and biological markers, will allow the identification of different developmental trajectories and then a better individuation of treatment in autism spectrum disorders.

Official Title
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Autism Spectrum Disorders: Clinical and Neurophysiological Evolutions Through a Functional Rehabilitation of Social Communication

Conditions
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Autistic Disorder

Intervention / Treatment
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* Other: functional rehabilitation of social communication


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: re-education of social communication Exclusion Criteria: multi-handicapped associated to ASD

Ages Eligible for Study
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Minimum Age: 12 Months
Maximum Age: 12 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: functional rehabilitation of social communication|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical changes between Baseline and Two years | Autism Diagnostic Observation Schedule (ADOS) | 2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| neurophysiological evaluations at baseline | Event related potentials (ERPs) Visual ERPs : P100 evoked by pattern reversing checkerboard stimuli , N170 evoked by faces auditive ERPs: N1c and MMN evoked with an oddball pardaigm using simple tones, MMN evoked with an oddball pardaigm using emotional voices | baseline | 
| neurophysiological evaluations at 1 year | Event related potentials (ERPs) Visual ERPs : P100 evoked by pattern reversing checkerboard stimuli , N170 evoked by faces auditive ERPs: N1c and MMN evoked with an oddball pardaigm using simple tones, MMN evoked with an oddball pardaigm using emotional voices | 1 year | 
| neurophysiological évaluations at 2 years | Event related potentials (ERPs) Visual ERPs : P100 evoked by pattern reversing checkerboard stimuli , N170 evoked by faces auditive ERPs: N1c and MMN evoked with an oddball pardaigm using simple tones, MMN evoked with an oddball pardaigm using emotional voices | 2 years | 
| Social and cognitive evaluations at baseline | Social and Cognitive Evaluation Battery (SCEB), | baseline | 
| Social and cognitive évaluations at 1 year | Social and Cognitive Evaluation Battery (SCEB), | 1 year | 
| Social and cognitive évaluations at 2 years | Social and Cognitive Evaluation Battery (SCEB), | 1 year | 
| Repetitive behaviors évaluations at baseline | Repetitive and Restrictive Behavior Scale (RRBS) | baseline | 
| Repetitive behaviors évaluations at one year | Repetitive and Restrictive Behavior Scale (RRBS) | 1 year | 
| Repetitive behaviors at two years | Repetitive and Restrictive Behavior Scale (RRBS) | 2 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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neurophysiology