The Efficacy Of Complete Mesocolic Excision With Central Vessel Ligation Technique On Lymph Nodes And Safety Margins Compared With Conventional Surgery For Colon Cancer Treatment

Study Overview
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Brief Summary
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Cancer Colon is one of the major public health problems worldwide. Complete eradication of the tumor with no recurrence or residual masses is a challenge which faces all the surgeons and medical staff all over the world. A lot of techniques were used to ensure 100 % eradication of the tumor and to cure the patients from cancer. Total Mesocolic Excision with Central Vessel Ligation is one of the recent techniques used for colon cancer surgeries. Here in the research the investigators answer the question of how this technique is superior and more beneficial in complete eradication of the tumor than the conventional surgery for colon cancer

Official Title
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The Efficacy Of Complete Mesocolic Excision With Central Vessel Ligation Technique On Lymph Nodes And Safety Margins Compared With Conventional Surgery For Colon Cancer Treatment

Conditions
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Cancer Colon

Intervention / Treatment
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* Procedure: Total Mesocolic Excision with Central Vessel Ligation
* Procedure: conventional surgery of cancer colon


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: • Adult male and female Age of or above 18 years. Tumor localization at the caecum, ascending colon, transverse colon, descending colon, sigmoid colon or rectosigmoid on preoperative endoscopy and radiographic imaging [barium enema or computed tomography (CT)] No history of familial adenomatous polyposis, ulcerative colitis or Crohn's disease Written informed consent Exclusion Criteria: • Contraindications to major surgery and American Society of Anaesthesiologists (ASA) Physical Status scoring 4 which means extreme systemic disorders which have already become an eminent threat to life regardless of the type of treatment. Infectious disease requiring treatment. Pregnant women Use of systemic steroids. Severe pulmonary emphysema or pulmonary fibrosis

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: patients for whom Complete mesocolic excision will be done<br> | Procedure: Total Mesocolic Excision with Central Vessel Ligation<br>* sharp dissection of the anatomical layers and the dissection of the visceral plane from the parietal one . In addition a central division of the feeding arteries at their origins is performed at the level of superior mesenteric artery for tumors of the right colon and at the level of inferior mesenteric artery or the aorta for tumors of the left colon .this allows for removal of the maximum number of lymph nodes possible.<br>|
| Active Comparator: patients had conventional surgery before<br> | Procedure: conventional surgery of cancer colon<br>* removal of the tumor with no ligation of the vessel centrally or removal of the whole mesocolon<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Lymph nodes harvest | Number of retrieved lymph nodes can be extracted by this technique | Two years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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cancer colon