Effect of Non-pharmacological Therapy on Cognitive Function of Patients With Cognitive Impairment

Study Overview
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Brief Summary
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Supervised nonpharmacologic therapy improve cognitive function in patients with Mild Cognitive Impairment

Official Title
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Effect of Non-pharmacological Therapy on Cognitive Function of Patients With Cognitive Impairment

Conditions
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Mild Cognitive Impairment

Intervention / Treatment
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* Other: Non-pharmacological therapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients 60 years and older with Mild Cognitive Impairment according to Petersen Criteria Phone number available Exclusion Criteria: Untreated depression Evidence of a reversible cause of cognitive decline Dementia of any type and stage Severe sensory deficit unresolved Metastatic cancer Hemoglobin level < 8g/dL Chronic Obstructive Pulmonary Disease Gold stage 3 or 4 Congestive Heart Failure decompensated, unstable angina o Functional Class IV according to New York Heart Association Participation in another protocol that prevents its participation in this research Chronic use of benzodiazepines, tricyclic antidepressants Patients whose place of residence can not attend the sessions

Ages Eligible for Study
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Minimum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Non-pharmacological therapy<br>This group will be supervised nonpharmacologic therapy | Other: Non-pharmacological therapy<br>* It consists of a weekly two-hour session. During the first hour yoga classes will taught by teacher, during second hour supervised cognitive training by a psychologist based on Memory Program designed by Memory Unit of Madrid<br>* Other names: Supervised nonpharmacologic therapy;|
| No Intervention: Control<br>This group will receive the standard treatment for mild cognitive impairment | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cognitive function | Cognitive function measured by Alzheimer's Disease Assessment Cognitive Scale (ADAS-Cog) sum of boxes after non-pharmacological intervention for six months. | six months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cognitive function six months after completing intervention | Cognitive function measured by Alzheimer's Disease Assessment Cognitive Scale (ADAS-Cog) six months after completing intervention | one year | 
| Depressive symptoms | Depressive symptoms measured by Geriatric Depression Scale (GDS) before and after intervention period | six months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Mild Cognitive Impairment, Cognitive training