Endothelin Concentrations in a Population With Cardiovascular Disease and Periodonitis

Study Overview
=================
Brief Summary
-----------------
Recently, a key role played in the ethiology of periodontitis has been highlighted by a Endothelin (ET-1). ET1 possess the ability to express surface antigens of endothelial and hematopoietic stem cells and to assist in maintaining vascular integrity and the repair mechanism of the endothelium. ET originate from bone marrow

Detailed Description
-----------------
The aim of the present study was to investigate the association between ET-1 in patients with periodontitis. Furthermore, the objective was to determine if the periodontal status influenced ET-1 levels.

Official Title
-----------------
Analysis of Endothelin Concentrations in a Population With Cardiovascular Disease and Periodontitis

Conditions
-----------------
Serum; Disease

Intervention / Treatment
-----------------
* Other: Observation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Presence of at least 16 teeth CP with a minimum of 40% of sites with a clinical attachment level (CAL) ≥2mm and probing depth (PD) ≥4mm; Presence of at least ≥2 mm of crestal alveolar bone loss verified on digital periapical radiographs Presence of ≥40% sites with bleeding on probing (BOP) Exclusion Criteria: Intake of contraceptives Intake of immunosuppressive or anti-inflammatory drugs throughout the last three months prior to the study Status of pregnancy or lactation Previous history of excessive drinking Allergy to local anaesthetic Intake of drugs that may potentially determine gingival hyperplasia such as Hydantoin, Nifedipine, Cyclosporin A or similar drugs.

Ages Eligible for Study
-----------------
Minimum Age: 21 Years
Maximum Age: 71 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Control<br>Evaluation of ET-1 level and correlation of ET-1 levels with periodontal and cardiovascular disease | Other: Observation<br>* Evaluation of ET-1 level and correlation of ET-1 levels with periodontal and cardiovascular disease<br>|
| Periodontitis<br>Evaluation of ET-1 level and correlation of ET-1 levels with periodontal and cardiovascular disease | Other: Observation<br>* Evaluation of ET-1 level and correlation of ET-1 levels with periodontal and cardiovascular disease<br>|
| Cardiovascular<br>Evaluation of ET-1 level and correlation of ET-1 levels with periodontal and cardiovascular disease | Other: Observation<br>* Evaluation of ET-1 level and correlation of ET-1 levels with periodontal and cardiovascular disease<br>|
| Periodontitis+Cardiovascular<br>Evaluation of ET-1 level and correlation of ET-1 levels with periodontal and cardiovascular disease | Other: Observation<br>* Evaluation of ET-1 level and correlation of ET-1 levels with periodontal and cardiovascular disease<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluation of ET-1 levels | Correlation of ET-1 levels with periodontal and cardiovascular disease | 1 year |