Optic Disc, Macula, and Retinal Nerve Fiber Layer Measurements Obtained by OCT in Thyroid Associated Ophthalmopathy

Study Overview
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Brief Summary
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The aim of the study is to compare the measurements of retinal nerve fiber layer (RNFL), macula and optical disc parameters obtained by optical coherence tomography (OCT), and intraocular pressure (IOP) between the patients with thyroid-associated ophthalmopathy (TAO) and healthy controls.

Detailed Description
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One hundred and thirty two eyes of 66 patients with TAO and 72 eyes of 36 healthy controls were included in the study. Proptosis level was determined by Hertel exophthalmometer. Optic disc, peripapillary retinal nerve fiber layer and macula parameters were measured by OCT. All measurements were compared between the patients and age and sex-matched healthy controls.

Official Title
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Optic Disc, Macula, and Retinal Nerve Fiber Layer Measurements Obtained by OCT in Thyroid Associated Ophthalmopathy

Conditions
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Thyroid Associated Ophthalmopathy

Intervention / Treatment
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* Device: Optical Coherence Tomography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient group consists the consecutive patients with thyroid associated ophthalmopathy consulted by endocrinology department. The control group was chosen among healthy volunteers who have no eye pathology, 20/20 vision (corrected or uncorrected), age and sex-matched with the patient group. Exclusion Criteria: For both groups, those who had significant sight impairment, high myopia ( < -5Diopters ), high hyperopia ( > +3Diopters ), optic disc anomaly, vitreoretinal interface disease, vascular and degenerative retinal diseases, cornea or lens opacity, ocular surgery history, glaucoma, neurological diseases that can affect the visual field, history of trauma, amblyopia, diplopia, keratitis, history of topical or systemic steroid

Ages Eligible for Study
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Minimum Age: 12 Years
Maximum Age: 73 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Thyroid ophthalmopathy<br>Thyroid associated ophthalmopathy patients were measured by optical coherence tomography. | Device: Optical Coherence Tomography<br>* All groups were measured by optical coherence tomography.<br>|
| Other: Control<br>Control group was consisted by age and sex- macthed healthy people adn they were measured by optical coherence tomography. | Device: Optical Coherence Tomography<br>* All groups were measured by optical coherence tomography.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Macular thickness | Macular thickness (micrometer) was measured by optical coherence tomography in patients and controls. | one year (between Jan 2012 and Jan 2013) | 
| Retinal nerve fiber layer thickness | Retinal nerve fiber layer thickness (micrometer) was measured by optical coherence tomography in patient and control groups. | one year (between Jan 2012 and Jan 2013) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Optic disc parameters | Optic disc parameters (morphologic structures) were obtained by optical coherence tomography for both groups. | one year (between Jan 2012 and Jan 2013) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Thyroid ophthalmopathy, optical coherence tomography