4D-CT for Pancreatic Adenocarcinoma in Radiotherapy Simulation

Study Overview
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Brief Summary
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The primary objective is to study the feasibility and efficacy of individually optimized CE 4D-CT for PDA in radiotherapy simulation.

Detailed Description
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Compared with current clinical practice, the individually optimized CE 4D-CT can potentially provide much improved tumor-to-parenchyma conspicuity of pancreatic adenocarcinoma. This will help the radiation oncologists or radiologists to contour the tumor with higher precision and confidence, and compute the tumor volume and tumor motion more accurately.

Official Title
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Individually Optimized Contrast-Enhancement 4D-CT for Pancreatic Adenocarcinoma in Radiotherapy Simulation

Conditions
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Pancreatic Adenocarcinoma

Intervention / Treatment
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* Other: Contrast-enhanced 4D computed tomography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients 18 years old or older Patients with PDA who have not had surgical removal of their tumor and who are planned for treatment with radiotherapy in the Radiation Oncology Department at the University of Maryland. Patients who have signed the contrast consent form and have been recommended by physicians to have contrast-enhanced CT scans. Patients who have signed the consent form for this study Exclusion Criteria: Pregnant or breast-feeding women. Patients with severely decreased renal function19-21. Patients with known severe allergic reactions to contrast. Patients who have difficulty lying flat on their back for extended periods of time. Patients with breaths per minute (BPM) rate less than 10, due to the limitation of 4D-CT image reconstruction software.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| All enrolled patients<br>Contrast-enhanced 4D computed tomography | Other: Contrast-enhanced 4D computed tomography<br>* All enrolled patients each underwent three CT scans: a 4DCT immediately following a contrast-enhanced 3DCT and an individually optimized contrast-enhanced 4DCT.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Individually Optimized Contrast-enhanced 4DCT for Radiotherapy Simulation | Image quality (anatomic details, motion artifacts, beam hardening and enhancement of pancreatic tissue and tumor were scored from 1 to 5, with 1 being very poor and 5 being excellent), CT number of pancreas and tumor, tumor-to-pancreas contrast, image noise and contrast-to-noise ration (CNR) were compared among contrast-enhanced (CE) 4DCT, CE 3DCT and 4DCT without contrast enhancement. | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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4D-CT, Contrast Enhanced CT, Radiotherapy Simulation