linjc16/ctgov huggingface dataset:
Effect of Oral Pregabalin on Hyperalgesia and Post-operative Pain in Patients Undergoing Nephrectomy Surgery: Sex Differential Study

Study Overview
=================
Brief Summary
-----------------
Hyperalgesia is known to be caused by the excitatory amino acid through NMDA receptor. GABA, an inhibitory amino acid, alters the opioid receptor sensitivity against pain resulting hyperalgesia. If the GABA level can be maintained at certain level, the progression into hyperalgesia can be averted. GABA related drugs are known to decrease the postoperative opioid consumption, lower the degree of pain, and prevent hyperalgesia. We hypothesize the effective postoperative pain management and the prevention of hyperalgesia from pregabalin, GABA analogue, and the possible sex difference in such effects of pregabalin.

Conditions
-----------------
Living Kidney Donors Undergoing VAMS-nephrectomy

Intervention / Treatment
-----------------
* Drug: Pregabalin_male
* Drug: Pregabalin_female
* Drug: Placebo_Men
* Drug: Placebo_Women


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 18, <51 years healthy patients accepted for video-assisted living donor nephrectomy Exclusion Criteria: Female patients who are pregnant or menopause Patients undergoing hormonal therapy Patients having neurologic disease or already taking GABA related drugs (pregabalin, gabapentin), or taking opioid drugs Insulin resistant diabetes Renal deficiency (eGFR < 60 ml/min/1.73 m2) Emergency operation, hemodynamically unstable patients Foreigner allergic to medication given in this study

Ages Eligible for Study
-----------------
Minimum Age: 19 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Pregabalin_male<br> | Drug: Pregabalin_male<br>* Pregabalin 150mg bid 1day Men<br>|
| Experimental: Pregabalin_female<br> | Drug: Pregabalin_female<br>* Pregabalin 150mg bid 1day Women<br>|
| Active Comparator: Placebo_male<br> | Drug: Placebo_Men<br>* Placebo durg<br>|
| Active Comparator: Placebo_female<br> | Drug: Placebo_Women<br>* Placebo_Women<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mechanical threshold | Mechanical threshold can be measured using von Frey filaments at both incision site and non-dominant arm | from 1 day before op to postop 48 hr |
Large Volume Bupivacaine 0.5% Versus Small Volume in Elective Caesarean Section

Study Overview
=================
Brief Summary
-----------------
To test the safety of high dose spinal in elective CS after prolonged sitting position.

Detailed Description
-----------------
This is a prospective double-blind randomized study, designed to include cases in two groups (using epical program for sample size calculation), one study groups and one control group (parallel). Each group should have at least 30 female patients scheduled for elective caesarean section with a total of 60 cases.

Official Title
-----------------
Large Volume Bupivacaine 0.5% Versus Small Volume in Elective Caesarean Section

Conditions
-----------------
Spinal Anesthesia

Intervention / Treatment
-----------------
* Drug: intrathecal 15 mg bupivacaine


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Full term pregnant female indicated for the elective section under spinal anesthesia with no history of medical importance Exclusion Criteria: Urgent cases, emergency cases, adverse medical history, anticoagulant treatment, associated pregnancy complication, failed spinal, surgical complication or refusal

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: CONTROL<br>one with intrathecal 12.5 mg bupivacaine | |
| Experimental: experimental<br>one group with intrathecal 15 mg bupivacaine | Drug: intrathecal 15 mg bupivacaine<br>* spinal anesthesia with a large dose of bupivacaine 0.5% in elective caesarean section<br>* Other names: large dose spinal;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| vital signs | blood pressure, heart rate | 45 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| complications | nausea, vomiting and total spinal | 45 minutes |
The Effect of Embryo Culture Under Low Oxygen Tension on Pregnancy Rates

Study Overview
=================
Brief Summary
-----------------
This study will determine whether the use of low oxygen tension during in vitro embryo culture may increase the pregnancy rates in women undergoing egg donation.

Detailed Description
-----------------
As far as oxygen (O2) tension is concerned, both oocytes and embryos from different mammalian species included the human are normally surrounded by values which are much less than half of atmospheric O2, ranging from high (8.7% O2) in the rabbit oviduct, rabbit and hamster uterus, to as low as 11 mm Hg (1.5% O2) in the monkey uterus. Even in the preovulatory follicle, oocytes are bathed within follicular fluids containing oxygen that range from > 1 to 5.5 % The aim of this study was to evaluate the impact the effect of low oxygen tension after day-3 embryo transfer in our egg donation programme on pregnancy and implantation rates.

Official Title
-----------------
A Randomized Controlled Trial Evaluation the Effect of Low Oxygen Tension on the Pregnancy Rate After Day 3 Embryo Transfer in an Egg Donation Programme.

Conditions
-----------------
Low Oxygen Tension

Intervention / Treatment
-----------------
* Other: Decreased oxygen concentration


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Women aged 25-45 years of age; In good mental and physical health; First or second of egg-recipient treatment; Embryo transfer on Day 3. One to three embryos will be transferred. BMI between 18-25 kg/m2. Exclusion Criteria: Uterine pathology or hydrosalpinx Recurrent miscarriage No chronic illnesses

Ages Eligible for Study
-----------------
Minimum Age: 25 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Hipoxia<br>The low oxygen tension group | Other: Decreased oxygen concentration<br>* The oxygen concentration is decreased during the in Vitro embryo culture.<br>|
| No Intervention: Control group<br>Conventional culture conditions | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical pregnancy rates per cycle |  | one month |
Frequency of Hymenoptera-stings in Patients Under Allergen-Specific Immunotherapy (SIT)

Study Overview
=================
Brief Summary
-----------------
In Switzerland, 3.5% of the population are suffering from hymenoptera venom allergy. The only causal treatment of hymenoptera alelrty is venom specific immunotherapy. There are however several reasons, which question the relatively broad application of this expensive treatment. That's why we aim at investigating the actual risk for hymenoptera stings in patients undergoing allergen specific immunotherapy against hymenoptera sting allergy

Official Title
-----------------
Frequency of Hymenoptera-stings in Patients Under and After Allergen-specific Immunotherapy: a Retrospective Data-analysis Considering Socio-economic Aspects

Conditions
-----------------
Hymenoptera Sting Allergy

Intervention / Treatment
-----------------
* Other: Observation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: Bee and/or Wasp allergic patients treated by SIT Exclusion criteria: None

Ages Eligible for Study
-----------------
Minimum Age: 5 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>Hymenoptera sting allergic patients under immunotherapy | Other: Observation<br>* Observation of sting frequency<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Maternal 25-hydroxy Vitamin D Level and Adverse Outcomes in Near Term and Full Term Neonates

Study Overview
=================
Brief Summary
-----------------
Eighty-eight pregnant women and their newborns were enrolled in a cross-sectional study. Maternal serum 25-OHD was measured by ELISA

Detailed Description
-----------------
Eighty-eight pregnant women and their newborns were enrolled in a cross-sectional study. Maternal serum 25-OHD was measured by ELISA.Maternal 25 (OH) vitamin D measurement: Blood samples for determination of serum 25 (OH) vitamin D were collected by venipuncture and processed as follows: 3 mL blood were collected into plain tubes and allowed to clot for 30 minutes, then it was centrifuged at 1500 round per minute for 15 minutes at room temperature and the serum was separated into clean, properly labeled tubes and stored at ≤ -20°C till assay. Serum 25 (OH) vitamin D level was assessed by Enzyme-Linked ImmunoSorbent Assay (ELISA) using DRG 25-OH Vitamin D (total) ELISA (DRG International, Inc., USA) according to manufacturer's instructions. Vitamin D deficiency is defined by 25(OH) D levels less than 20 ng/d

Official Title
-----------------
Maternal 25-hydroxy Vitamin D Level and Adverse Outcomes in Near Term and Full Term Neonates

Conditions
-----------------
Neonatal Outcome

Intervention / Treatment
-----------------
* Procedure: Vaginal delivery
* Procedure: Cesarean Section


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy women Term pregnancy Exclusion Criteria: any chronic illness as chronic hypertension or pregestational diabetes pregnancy-related illnesses as preeclampsia, gestational diabetes multiple pregnancy

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Deficient Vit D<br>Mothers with serum 25(OH) D levels less than 20 ng/dl | Procedure: Vaginal delivery<br>* classic vaginal delivery<br>Procedure: Cesarean Section<br>* routine lower segment cesarean scetion<br>|
| Normal vit D<br>Mothers with serum 25(OH) D levels more than 20 ng/dl | Procedure: Vaginal delivery<br>* classic vaginal delivery<br>Procedure: Cesarean Section<br>* routine lower segment cesarean scetion<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Neonatal intensive care unit admission | Admission of the neonate to NICU | 24 hours after delivery |
Nasopharyngeal Carcinoma Screening in Zhongshan City

Study Overview
=================
Brief Summary
-----------------
The primary objective is to determine the early diagnosis rate and mortality rate of the Nasopharyngeal Carcinoma (NPC) in the study population. The secondary objective is to determine the incidence of NPC in the study population.

Detailed Description
-----------------
The research is to evaluate the effect of NPC screening, also as an extended study of Screening for Nasopharyngeal Carcinoma in High Risk Populations (NCT00941538). The program was conducted in Xiaolan and Minzhong towns of Zhongshan city in 2012. All participants will be tested for anti-EBV antibody by using serum samples. Participants are stratified into those having high, moderate and low antibody levels, those having moderate antibody levels are invited to retest annually in the following 3 years and those found to have high antibody levels on these occasions are referred to centers for diagnostic workup for NPC.

Official Title
-----------------
Serology Screening Test for the Detection of Nasopharyngeal Carcinoma in Zhongshan City

Conditions
-----------------
Nasopharyngeal Carcinoma

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Subject residents in Zhongshan city Subject is 30 to 59 years of age inclusive Subject has no medical record of nasopharyngeal carcinoma ECOG 0-2 Subject has psychical condition and well consciousness Subject is able to comprehend, sign, and date the written informed consent document to participate in the study. Exclusion Criteria: Subject has heavy cardiovascular, liver or kidney disease Subject has medical record of nasopharyngeal carcinoma Subject who is not residing in Zhongshan City

Ages Eligible for Study
-----------------
Minimum Age: 30 Years
Maximum Age: 59 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Screening cohort<br>All participants will be tested for anti-EBV antibody by using serum samples. Participants are stratified into those having high, moderate and low antibody levels, those having moderate antibody levels are invited to retest annually in the following 3 years and those found to have high antibody levels on these occasions are referred to centers for diagnostic workup for NPC. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The early detection rate (stage I and II) of Nasopharyngeal Carcinoma |  | 10 years | 
| The mortality rate of Nasopharyngeal Carcinoma |  | 10 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The incidence of Nasopharyngeal Carcinoma |  | 10 years |
Bacterial Microbiota In The Tonsils Of Children

Study Overview
=================
Brief Summary
-----------------
We, the investigators, propose to look at the bacteria on and in tonsils using gene microarrays. We expect to find previously reported bacteria but also the possibility of previously undetected organisms. We think that the bacterial pathogens present on the tonsillar surface are different from the tonsil core. And we also think that the bacteria of the tonsil surface will differ between patients undergoing adenotonsillectomy and normal controls with no adenotonsillar problems.

Official Title
-----------------
Bacterial Microbiota In The Tonsils Of Children Undergoing Adenotonsillectomy And Normal Controls

Conditions
-----------------
Adenotonsillitis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Inclusion criteria for subjects undergoing surgery: Age 2-12 yrs Both males and females Undergoing adenotonsillectomy Additional criteria for subjects in the recurrent infection group: Sleep questionnaire score <5 Designated by surgeon as having recurrent adenotonsillitis as reason for surgery Additional criteria for subjects in the airway obstruction group: Sleep questionnaire score >5 Presence of positive polysomnogram desired but not necessary Designated by surgeon as having airway obstruction or sleep apnea as reason for surgery Inclusion criteria for control subjects: Age 2-12 yrs Both males and females No history of adenotonsillar problems Sleep questionnaire score < 5 Exclusion Criteria: Exclusion Criteria for both groups: Antibiotic intake in the past 10 days Other major medical problems (immune deficiency, cystic fibrosis, malignancy) In the surgery group: designated by surgeon as having both recurrent adenotonsillitis and airway obstruction as reason for surgery Menstruating females

Ages Eligible for Study
-----------------
Minimum Age: 2 Years
Maximum Age: 12 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Control<br>No tonsilar or adenoid problems | |
| Adenotonsillectomy (recurrent)<br>Recurrent adenotonsillitis | |
| Adenotonsillectomy (obstruction)<br>Upper airway obstruction | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
CT Based Definition of a Tissue Window for Acute Stroke Thrombolysis

Study Overview
=================
Brief Summary
-----------------
Aim of this study is to define a CT-based tissue window for stroke thrombolysis. Our primary hypothesis is that patients with a tissue window (favourable non-contrast CT (NCCT) scan and an intracranial occlusion on CT angiography (CTA) or perfusion-CT-mismatch (area of reduced cerebral blood flow (CBF) > area of reduced cerebral blood volume (CBV)) represent a significant proportion (> 20%)of acute stroke patients and therefore are an important target group for future interventional studies patients with a tissue window suffer an unfavourable outcome (> 50 % mRS =>4 at 3 months)if the occluded artery was not recanalized.

Official Title
-----------------
Observational Study of Multimodal CT in Acute Ischemic Stroke to Define a Tissue Window for Thrombolysis

Conditions
-----------------
Stroke

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: ischemic anterior circulation stroke last seen normal < 12 hours stroke severity => 3 on the National Institute of Health Stroke Scale multimodal CT stroke protocol performed informed consent obtained Exclusion Criteria: premorbid modified Rankin Scale score > 3 contraindications to contrast media application pregnancy or breast feeding subacute stroke > 50 % of MCA territory CT evidence of non-vascular cause of stroke symptoms

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| modified Rankin Scale scores 0-2 |  | 90 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
stroke, ischemic, computed tomography, thrombolysis
Trial of Myopia Prevention Using +3D Lenses

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to assess whether a short-term imposed myopic defocus is effective in preventing the development and progression of juvenile-onset myopia in Chinese children.

Detailed Description
-----------------
To determine if +3D lenses wearing for half an hour everyday prevents the development and progression of myopia in school children. To identify ocular parameters and risk factors at baseline associated with development and progression of myopia.

Official Title
-----------------
A Randomised, Controlled Trial of Prevention of Juvenile-Onset Myopia in Chinese Children

Conditions
-----------------
Myopia

Intervention / Treatment
-----------------
* Device: +3D Lenses


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All children in the selected class are enrolled Exclusion Criteria: Hyperopia > +2.0 D High myopia > -6.0 D Astigmatism> 1.5 D Anisometropia > 1.5 D Strabismus and amblyopia Any ocular, systemic, or neurodevelopmental conditions that could influence refractive development Chronic medication use that might affect myopia progression or visual acuity Already receiving other treatment for progressing myopia
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>wear +3D glasses for 30 minutes per day and engage in activities which require vision at more than 1m | Device: +3D Lenses<br>* wear +3D glasses for 30 minutes per day and engage in activities which require vision at more than 1m<br>|
| No Intervention: 2<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Axial Length of eyes |  | Annual | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Autorefraction |  | Annual |