Biomarkers and Postoperative Delirium in Elderly Patients

Study Overview
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Brief Summary
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This study intends to verify and explore the correlation of neuroinflammation biomarkers in cerebrospinal fluid and plasma of elderly patients undergoing hip replacement with postoperative delirium, so as to achieve a new method to predict whether patients will develop postoperative delirium and improve the prognosis of elderly patients with postoperative delirium. Reduce the probability of postoperative complications, improve the long-term survival rate of patients after surgery.

Official Title
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Relationship Between Neuroinflammatory Biomarkers and Postoperative Delirium in Elderly Patients With Hip Replacement

Conditions
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Postoperative Delirium

Intervention / Treatment
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* Behavioral: postoperative delirium


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age≥65 Patients undergoing hip replacement under spinal anesthesia ASA grade I III; Voluntarily participate in this study, and informed consent was signed by the patients themselves and their families Exclusion Criteria: Patients with multiple fractures and trauma Patients with preoperative cognitive dysfunction determined by MMSE scale; Severe impairment of hearing, visual and language system functions; Not suitable for or unwilling to undergo subarachnoid anesthesia Patients who refuse to participate or cannot cooperate.

Ages Eligible for Study
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Minimum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Delirium<br> | Behavioral: postoperative delirium<br>* Postoperative delirium (POD) occurs within 1 week after surgery in patients, with obvious time characteristics, mainly occurring within 1-3 days after surgery. Postoperative delirium has adverse effects on the short and long term prognosis of patients. Patients with delirium have an increased risk of postoperative complications, perioperative death, longer hospital stay and increased medical costs during hospitalization.<br>|
| Non-delirium<br> | Behavioral: postoperative delirium<br>* Postoperative delirium (POD) occurs within 1 week after surgery in patients, with obvious time characteristics, mainly occurring within 1-3 days after surgery. Postoperative delirium has adverse effects on the short and long term prognosis of patients. Patients with delirium have an increased risk of postoperative complications, perioperative death, longer hospital stay and increased medical costs during hospitalization.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| neuroinflammatory biomarkers | Whether there are changes in neuroinflammatory biomarkers(Ykl40(pg/mL), procalcitonin(ng/mL), IL-17A,IL-23,INF-γ(IU), Tau(pg/mL), amyloid beta(pg/mL),etc) in cerebrospinal fluid and plasma between delirium patients and non-delirium patients before and after operation. | preoperative、24 hours after surgery、48 hours after surgery |