linjc16/ctgov huggingface dataset:
Studying Protein Expression in Tissue Samples From Younger Patients With Rhabdomyosarcoma

Study Overview
=================
Brief Summary
-----------------
This research trial studies protein expression in tissue samples from younger patients with rhabdomyosarcoma. Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors find better ways to treat cancer.

Detailed Description
-----------------
PRIMARY OBJECTIVES: I. To investigate (in two stages) which proteins are overexpressed in association with 12q13-q14 amplification by applying fluorescence in situ hybridization (FISH) and immunohistochemical (IHC) assays to a panel of alveolar rhabdomyosarcomas (ARMS) cases organized into tissue microarrays. OUTLINE: Formalin-fixed paraffin-embedded tissue samples are analyzed for 12q13-q14 frequency and protein overexpression by FISH and IHC.

Official Title
-----------------
Tissue Microarray Studies of the 12q13-q14 Amplicon in Alveolar Rhabdomyosarcoma

Conditions
-----------------
Alveolar Childhood Rhabdomyosarcoma, Embryonal Childhood Rhabdomyosarcoma, Previously Treated Childhood Rhabdomyosarcoma, Previously Untreated Childhood Rhabdomyosarcoma, Recurrent Childhood Rhabdomyosarcoma

Intervention / Treatment
-----------------
* Other: laboratory biomarker analysis


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Slides of the 2006 alveolar rhabdomyosarcoma (ARMS) TMA and the 2009 ARMS/anaplastic embryonal rhabdomyosarcoma (ERMS) TMA PAX3-FOXO1-positive tumors PAX7-FOXO1-positive tumors Fusion-negative tumors

Ages Eligible for Study
-----------------
Maximum Age: 21 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Correlative studies<br>Formalin-fixed paraffin-embedded tissue samples are analyzed for 12q13-q14 frequency and protein overexpression by FISH and IHC. | Other: laboratory biomarker analysis<br>* Correlative studies<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Amplification and fusion status as a result of the 12q13-q14 amplification event | Fisher's exact test will be used. For a contingency table other than 2 x 2, the Freeman-Halton test (an extension of Fisher's exact test) will be applied instead. | Baseline |
Laparoscopic Supracervical Hysterectomy Versus Total Laparoscopic Hysterectomy

Study Overview
=================
Brief Summary
-----------------
The purpose of this research study is to evaluate whether there is any difference in recovery time and return to normal activities following a laparoscopic supracervical hysterectomy (LSH) compared with total laparoscopic hysterectomy (TLH). Both types of hysterectomies are commonly performed at our institution. Patients will be assigned by chance (like a coin toss) to have either a LSH or a TLH. Preoperatively, participants will complete a quality of life questionnaire (SF-36), a sexual function questionnaire (FSFI)and a 3 question questionnaire about urinary function (3IQ). Following surgery participants will be asked to keep a diary of pain symptoms and use of narcotics. The diary will be filled out daily until patients have resumed normal activities from prior to the surgery. The SF-36 will be completed again 6 weeks following the original surgery. 6 months following surgery participants will receive a copy of the SF-36 and the FSFI in the mail. They will also be asked questions about urinary symptoms and persistent vaginal bleeding.

Official Title
-----------------
LSH vs. TLH, A Randomized Single Blind Trial

Conditions
-----------------
Gynecologic Diseases

Intervention / Treatment
-----------------
* Procedure: Laparoscopic supracervical hysterectomy
* Procedure: Total laparoscopic hysterectomy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Candidates for laparoscopic hysterectomy for benign indications Exclusion Criteria: Malignancy of the uterus, cervix or adnexa pre-malignant changes of the uterus, cervix or adnexa history of severe cervical dysplasia (CIN II or above)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: 1<br>Laparoscopic supracervical hysterectomy (LSH) | Procedure: Laparoscopic supracervical hysterectomy<br>* Patients will be randomized to LSH (retaining the cervix) and TLH (cervix removal)<br>|
| Active Comparator: 2<br>Total Laparoscopic Hysterectomy (TLH) | Procedure: Total laparoscopic hysterectomy<br>* Patients will be randomized to either removal or retention of cervix<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Return to normal activities |  | 3-6 weeks after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sexual function |  | 6 months after surgery | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Hysterectomy, Laparoscopic
Training Procedural Simulation of Nurses in Reducing Complications Related to Arteriovenous Fistula Puncture

Study Overview
=================
Brief Summary
-----------------
Interest of training in procedural simulation of nurses in the reduction of complications related to arteriovenous fistula puncture in hemodialysis patients

Detailed Description
-----------------
Primary objective : To compare the number of complications related to arteriovenous fistula (AVF)puncture before and after a complete simulation training program, on a fistula arm of procedural simulation (conceptualization of the approach + puncture + palpation + identification + use of ultrasound) Secondary objective (s): Compare other adverse events related to AVF puncture during a hemodialysis session

Official Title
-----------------
Interest of Training in Procedural Simulation of Nurses in Reducing Complications Related to Arteriovenous Fistula Puncture in Chronic Hemodialysis Patients

Conditions
-----------------
Nurse's Role, Simulation, Arteriovenous Fistula

Intervention / Treatment
-----------------
* Other: Simulation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients whose nurse is trained in hemodialysis receiving a FAV puncture in the hemodialysis unit of the nephrology department, dialysis, transplantation Exclusion Criteria: Patients with AVF puncture in the emergency / withdrawal area of the nephrology department, dialysis, transplantation
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Simulation|pre-training observation training post training observation|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Complications related to arteriovenous fistula puncture (AVF) | Number of complications of fistula puncture : either failed unipuncture puncture either failed bipunctional puncture either simple hematoma either hematoma does not allow the continuation of dialysis | 25 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Adverse events related to AVF puncture during a hemodialysis session | Number of perdialytic bleeding : accidental removal of the needle | 25 days | 
| Adverse events related to AVF puncture during a hemodialysis session | Pain score (EN digital scale) felt at the time of puncture | 25 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Task trainning, Procedural simulation
Outcomes After Repair of Acute Rotator Cuff Tears

Study Overview
=================
Brief Summary
-----------------
Few studies are considering acute traumatic rotator cuff tears in previously asymptomatic patients. The purpose of the current study was to investigate if delay of surgery, age at repair and the number of cuff tendons involved affected the structural and clinical outcomes.

Official Title
-----------------
Structural and Clinical Outcomes After Repair of Acute Rotator Cuff Tears

Conditions
-----------------
Rotator Cuff Tear

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: significant trauma to the shoulder sudden onset of symptoms asymptomatic in the shoulder before trauma pseudoparalysis in the shoulder after trauma full thickness rotator cuff tear of at least one tendon Exclusion Criteria: patients with previous or gradual onset of symptoms in the traumatised shoulder partial rotator cuff tear displaced fracture

Ages Eligible for Study
-----------------
Minimum Age: 42 Years
Maximum Age: 83 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
rotator cuff tear, rotator cuff repair, age, timing to surgery
UMP Lifestyle Medicine Program

Study Overview
=================
Brief Summary
-----------------
To systematically follow patients seen at the University of Minnesota's Lifestyle Medicine Program for Weight Management.

Official Title
-----------------
UMP Lifestyle Medicine Program

Conditions
-----------------
Obesity

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All patients seen who sign medical release form Exclusion Criteria: None

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Body weight change | Body weight change from clinical program entry until discharge | 3 - 60 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Body fat percentage | Assess body fat percentage change from clinical program entry until discharge | 3-60 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
obesity
Lanreotide as Treatment of Polycystic Livers

Study Overview
=================
Brief Summary
-----------------
To assess the efficacy of lanreotide in controling total liver volume in patients with polycystic livers this study will be performed. A minimum of 38 patients will be recruited and randomized (1:1) to receive either verum or placebo. Lanreotide is already used in other disease states and found to be safe and non-toxic.

Official Title
-----------------
Long-Acting Lanreotide as a Volume Reducing Treatment of Polycystic Livers

Conditions
-----------------
Polycystic Liver Disease, Hepatomegaly, Liver Diseases, Polycystic Kidney, Autosomal Dominant

Intervention / Treatment
-----------------
* Drug: Placebo
* Drug: Lanreotide


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 18 yrs-of age Multiple cysts > 20 Cooperating patient Is willing and able to comply with the study drug regimen and all other study requirements Willingness to give written informed consent Exclusion Criteria: Use of oral anticonceptives or estrogen suppletion Females who are pregnant or breast-feeding History or other evidence of chronic pulmonary disease associated with functional limitation History of severe cardiac disease History or other evidence of severe illness or any other conditions which would make the patient, in the opinion of the investigator, unsuitable for the study Symptomatic gallstones Renal failure requiring hemodialysis

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 88 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: 2<br>Placebo | Drug: Placebo<br> <br> |
| Experimental: 1<br>Lanreotide | Drug: Lanreotide<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Reduction of total liver volume as determined by CT scan |  | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Reduction of liver volume and individual cyst volume on CT scan. |  | 6 months | 
| Change of kidney volume and individual cyst volume on CT scan |  | 6 months | 
| Symptom evaluation by (validated) questionnaires |  | 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Polycystic Liver Disease, Autosomal Dominant Polycystic Kidney Disease, Liver cyst, Lanreotide
The Efficacy of Selective Laser Trabeculoplasty

Study Overview
=================
Brief Summary
-----------------
Selective laser trabeculoplasty (SLT) is a new method to reduce intraocular pressure in eyes with open angle glaucoma or ocular hypertension. SLT may also be effective for cases with previously failed ALT procedures. We will study the efficacy and safety of the SLT procedure.

Detailed Description
-----------------
Selective laser trabeculoplasty (SLT) has been shown to be a safe, well tolerated, and effective intraocular pressure reduction therapy for several forms of open-angle glaucoma. SLT produces significantly less disturbance to the trabecular meshwork and is theoretically more repeatable than the ALT procedure. This retrospective research will begin with cases treated in 2001. It will evaluate whether SLT is effective for patients who have had prior treatment with ALT and it will determine whether the IOP lowering effect is sustainable over time. It will also assess the efficacy of repeated SLT procedures.

Official Title
-----------------
Clinical Results of Selective Laser Trabeculoplasty in Treatment of Open Angle Glaucoma

Conditions
-----------------
Primary Open Angle Glaucoma, Ocular Hypertension, Pseudo-Exfoliative Glaucoma, Pigment Dispersion Glaucoma

Intervention / Treatment
-----------------
* Procedure: Selective laser trabeculoplasty


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with primary open angle glaucoma, ocular hypertension, pseudo exfoliative glaucoma, pigment dispersion glaucoma Exclusion Criteria: History of prior invasive glaucoma surgery

Ages Eligible for Study
-----------------
Minimum Age: 0 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Selective laser trabeculoplasty|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Primary open angle glaucoma, Ocular hypertension, Pseudo-exfoliative glaucoma, Pigment Dispersion glaucoma, selective laser trabeculoplasty, intraocular pressure
Survivorship and Outcomes of Robotic-Arm Assisted Medial Unicompartmental Knee Arthroplasty

Study Overview
=================
Brief Summary
-----------------
The purpose of the study is to determine the survivorship of robotic-arm assisted MCK medial onlay Unicompartmental knee arthroplasty implants at two, five and tem year follow up.

Detailed Description
-----------------
The purpose of the study is to determine the survivorship of robotic-arm assisted MCK medial onlay unicompartmental knee arthroplasty implants at two, five, and ten year follow up. Study participants will also be asked about their level of satisfaction with their knee function following their robotic-arm assisted Unicompartmental Arthroplasty.

Official Title
-----------------
Survivorship and Outcomes of Robotic-Arm Assisted Medial Unicompartmental Knee Arthroplasty

Conditions
-----------------
Osteoarthritis

Intervention / Treatment
-----------------
* Device: Robotic-arm assisted medical MCK implant


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All patients over 21 years of age who underwent primary robotic-arm assisted unicompartmental arthroplasty and received a medial MCK onlay implant and are at least 24 months post-operative. Patient has signed an IRB approved Informed Consent Form or with IRB approved waiver of written consent, patient has verbally consented to study participations. Patient willing to comply with follow up. Exclusion Criteria: Patient will be excluded from participation in the study if they are cognitively unable to answer questions related to their index procedure and health related quality of life forms. Patient had active infection Medial MCK onlay implants were implanted without bone cement Patients did not have sufficient bone stock to allow for insertion and fixation of components Patient did not have sufficient soft tissue integrity to allow for stability Patient had a neurological or muscular deformity that did not allow for control of the knee.

Ages Eligible for Study
-----------------
Minimum Age: 21 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: Robotic-arm assisted medical MCK implant|Robotic-arm assisted medical MCK implant system to replace the medial compartment of the knee.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| % of patients with revisions | To determine the revision rate in this patient population | 10 year after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| % of patients with revisions | To determine the revision rate in this patient population | 2 years after surgery | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
osteoarthritis, medial, unicompartmental
The Effect Of Occupational Therapy On Sensory-Based Feeding Problems

Study Overview
=================
Brief Summary
-----------------
Feeding problems are common in individuals with Autism Spectrum Disorder (ASD).This study was planned to investigate the effect of occupational theraphy on sensory feeding problems in ASD.

Detailed Description
-----------------
Feeding problems are common in individuals with Autism Spectrum Disorder (ASD).This study was planned to investigate the effect of occupational theraphy on sensory feeding problems in ASD.

Official Title
-----------------
The Effect Of Occupational Therapy On Sensory-Based Feeding Problems Of Children Wth Autism Spectrum Disorder

Conditions
-----------------
Feeding Disorder, Autism Spectrum Disorder, Sensory Integration Disorder (Disorder)

Intervention / Treatment
-----------------
* Other: Family Training
* Other: Occupational Therapy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: ASD Feeding problems

Ages Eligible for Study
-----------------
Minimum Age: 3 Years
Maximum Age: 10 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Control<br>Children with ASD | Other: Family Training<br>* Family Training<br>|
| Experimental: Intervention<br>Children with ASD | Other: Occupational Therapy<br>* Occupational Therapy<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Dunn Sensory Profile | It is a norm-referenced, parent-report questionnaire. The parent rates frequency of each item on a 5-point Likert scale from 1= always to 5= never. It reports the frequency of behavioural occurrences that are used to measure the patterns of performance indicative of difficulties experienced in sensory processing | 8 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| BAMBİ | The BAMBI is rated based on a parent proxy report, with a 5-point grading type scale (1 = Never/Very Rarely -5 = At Almost All Mealtimes). It was designed to capture mealtime behaviors specific to children with ASD. | 8 weeks | 
| STEP | It is used for to identify the feeding problems of persons with ID in terms of (a) risk of aspiration, (b) food selectivity, (c) feeding skills deficits, (d) food refusal and associated behavior problems, and (e) nutrition-related behavior problems | 8 weeks |