Effect of Different Types of Carbohydrates Consumed After Exercise on Blood Fat Levels

Study Overview
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Brief Summary
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The increase in fat (i.e. triglyceride) in the blood after a meal is a well-established risk factor for heart disease (Nordestgaard et al. 2007). Endurance exercise is beneficial for improving the blood lipid response to a subsequent meal; that is, the appearance of fat (triglyceride) in the blood is less after a meal if endurance exercise was performed shortly before (i.e. within half a day) of the meal (Petit et al. 2003). This benefit of exercise is unfortunately negated if the after-exercise food choice to replace the calories expended during exercise is one containing high glycemic index carbohydrates. For example, if a high glycemic index carbohydrate is consumed after an evening exercise session, the exercise no longer has an effect of lowering triglyceride in the blood after a meal consumed the next morning (Harrison et al. 2009; Burton et al. 2008). Very rarely do people perform an exercise session and then fast until their next meal hours later. The more common practice is to consume food immediately after the exercise to enhance recovery and because hunger is stimulated with exercise. Consuming carbohydrate with a low glycemic index has been shown to reduce the level of fat in the blood following a subsequent meal (Gruendel et al. 2007). To date, no studies have examined the effects of consuming a low-glycemic index meal after exercise on the blood fat response to a subsequent meal. The specific objective of our research is to determine the effect of consuming low glycemic index lentils after an endurance exercise session on the blood fat (triglyceride) response to a subsequent meal. Twenty-five overweight or obese men will have their blood triglycerides measured four times over six hours after a high-fat morning meal following four different conditions, in a randomized, counterbalanced, cross-over design (i.e. the 25 subjects will each participate in all four conditions, where the order of conditions for each person is randomized): 1) After exercise (90 minutes of moderate intensity walking) is performed the evening before, followed by caloric replacement with a high-glycemic index meal (i.e. white bread and instant mashed potatoes); 2) After the same exercise is performed the evening before, followed by caloric replacement with a lentil-based meal; 3) After the same exercise is performed the evening before, followed by fasting; 4) After a no exercise/ no meal condition (i.e. control condition). In addition to measuring blood triglycerides we will measure blood insulin, free fatty acid, high density lipoproteins, low density lipoproteins, and glucose levels as these are also related to cardiovascular disease risk and may be altered with exercise and lentil consumption. We will also measure the muscle's ability to burn fat (i.e. fat oxidation) by assessing respiratory gases (oxygen consumption and carbon dioxide output) after the high-fat meal because we expect exercise and lentils to increase fat oxidation. Our expected results are that consuming lentils after endurance exercise will lower the blood triglyceride response to a subsequent meal compared to exercise alone or when high-glycemic index carbohydrates are consumed after the exercise.

Official Title
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Effect of Exercise and Glycemic Index of Carbohydrate Feeding on Postprandial Lipid Metabolism

Conditions
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Hyperlipidemia

Intervention / Treatment
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* Behavioral: Exercise
* Other: Diet (meal type)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Body mass index of 25 or greater 18-44 years of age Exclusion Criteria: diabetics smokers those taking medications for cholesterol or glucose

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 44 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Exercise only<br>90 minutes of exercise | Behavioral: Exercise<br> <br> |
| Experimental: Exercise and high glycemic index meal<br>90 minutes of exercise followed by a high glycemic index meal matched for calories expended during the exercise | Behavioral: Exercise<br> <br> Other: Diet (meal type)<br> <br> |
| Experimental: Exercise and low glycemic index meal<br>90 minutes of exercise followed by a low glycemic index meal matched for calories expended during the exercise | Behavioral: Exercise<br> <br> Other: Diet (meal type)<br> <br> |
| No Intervention: No exercise and no meal<br>No exercise and no meal | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in blood triglycerides |  | Change from baseline at 6 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in blood glucose |  | Change from baseline at 6 hours | 
| Change in fat oxidation |  | Change from baseline at 6 hours | 
| Change in low density lipoproteins |  | Change from baseline at 6 hours | 
| Change in high density lipoproteins |  | Change from baseline at 6 hours | 
| Change in total cholesterol |  | Change from baseline at 6 hours | 
| Change in insulin level |  | Change from baseline at 6 hours |