Open to Laparoscopic Reverse Conversion of Perforated Appendicitis

Study Overview
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Brief Summary
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A Prospective Randomized Controlled Trial of Reverse Conversion (Open to Laparoscopic) in management of Acute Perforated Appendicitis

Detailed Description
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Introduction: Acute appendicitis (AA), a frequent intra-abdominal surgical pathology, necessitates a thorough awareness of its symptoms, examination, diagnosis, and total surgical management. The surgical approach to AA is appendectomy; nevertheless, the medical literature continues to argue the merits of open vs laparoscopic surgery. As with other laparoscopic surgical techniques, the literature reports lower discomfort, earlier resumption of oral feeding and shorter hospital stay following laparoscopic appendectomy (LA) as compared to open appendectomy (OA). Additionally, laparoscopy has some drawbacks such as greater cost and lengthier operating durations as compared to open surgery. The goal of this clinical study: was to compare open appendectomy versus laparoscopic conversion from open (reverse conversion) for the treatment of acute perforated appendicitis in our setting. Patients and procedures: 426 patients had perforated appendectomy and divided between two groups: group A (interventional) 213 patients who were subjected to the reverse conversion technique and group B (control)213 patients who were operated by the open technique. The key end goals for comparing both groups were the rates of intraabdominal abscess, rates of wound infection, rates of ileus and rates of reoperation. The hospital length of stay and the operative time were used as secondary end goals for comparison.

Official Title
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A Prospective Randomized Controlled Trial of Reverse Conversion (Open to Laparoscopic) in Management of Acute Perforated Appendicitis

Conditions
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Acute Appendicitis With Rupture, Laparoscopic Surgery, Sepsis, Abdominal Abscess

Intervention / Treatment
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* Procedure: reverse conversion technique


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: symptoms consistent with acute perforated appendicitis, had ultrasound or computed tomography (CT) evidence of acute perforated appendicitis, ages ranging from 16 to 65 years. Exclusion Criteria: radiological evidence of appendicular mass, septic shock or multi-organ failure (MOF) at presentation, Diabetes Mellitus (DM), renal failure, morbid obesity recent (6-month) history of thromboembolic disease immunomodulators, a history of inflammatory bowel disease (IBD), postoperative pathological report of the removed appendix revealed carcinoid or Crohn's disease, American Society of Anesthesiology (ASA) classification more than II.

Ages Eligible for Study
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Minimum Age: 16 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: group A<br>the group who was subjected to the reverse conversion technique | Procedure: reverse conversion technique<br>* converting open appendectomy to laparoscopic technique for proper control of intraabdominal sepsis<br>* Other names: laparoscopic lavage;|
| No Intervention: group B<br>the control group who was completed by open technique | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the rates of intraabdominal abscess | rates of complications | 3 months post operative | 
| rates of wound infection | rates of complications | 3 months post operative | 
| rates of ileus |  | Baseline (Hospital admission) | 
| rates of reoperation |  | 3 months post operative | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The hospital length of stay | the length of hospital stay | up to 3 months | 
| the operative time | Time of performing the procedures | Intraoperative | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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reoperation, laparoscopic, appendectomy, reverse conversion, intraabdominal abscesses