Anesthetic Cost Analysis With Desflurane in Automated Gas Control Mode

Study Overview
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Brief Summary
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Inhalation agents constitute the major part of anesthetic drug costs (20% - 25%) and a significant portion of the applied inhalation agents are thrown into the atmosphere through the waste gas system without being absorbed by the patient. The amount of waste gas is directly correlated to the fresh gas flow (FGF). Reducing the TGA during general anesthesia reduces the consumption of inhalant agents and contributes to the reduction of greenhouse gas pollution. Risks such as hypoxia, hypercapnia, inadequate depth of anesthesia and potential toxic gas accumulation were associated with low flow anesthesia, but the patient was provided with adequate safety by following pulse oximetry, capnography, FiO2 and anesthetic gas analysis. We aimed to perform anesthetic cost analysis and patient security in automated gas control mode (AGC).

Detailed Description
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After the ethical approvel 60 adult patients scheduled for hepatectomy will be taken to study. Patients will be monitored after they are taken to the operating room (ECG, NIBP, SpO2, Body Temp, BIS, NIRS, PVI, PI, ORI). After the anesthesia induction and tarakeal entubation, first twenty patient will take 300 mL fresh gas flow with AGC mode (group 1), Second twenty patient will take 600 mL fresh gas flow with AGC mode (group 2), third twenty patient will take 600 mL fresh gas flow with manually. Hemodynamic and gas consumption data will be recorded. An operating room will be reserved for this study.

Official Title
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Anesthetic Cost Analysis With Desflurane in Automated Gas Control Mode With Maquet Flow-i Anaesthesia Machine

Conditions
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Safety Issues

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adult patients undergoing hepatectomy with general anesthesia Exclusion Criteria: Essential data missing Patient participating in other research projects Drug allergy Anesthetic complication story

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group 1<br>The patient who receive 300 mL fresh gas flow with AGC mode during the general anesthesia | |
| Group 2<br>The patient who receive 600 mL fresh gas flow with AGC mode during the general anesthesia | |
| Group 3<br>The patient who receive 600 mL fresh gas flow with manuelly during the general anesthesia | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Amount of used anesthetic gas (desflurane) | Amount of used desflurane will be determined in milliliter by anesthesia machine (Maquet Flow i40) for each patient. | Through study completion, an average of 2 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Heart rate | Heart rate/min | Through study completion, an average of 2 month | 
| Mean arterial pressure | Mean arterial pressure (mm/Hg) | Through study completion, an average of 2 month | 
| Peripheral oxygen saturation | Peripheral oxygen saturation (%) | Through study completion, an average of 2 month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Low flow anesthesia, Desflurane, Cost analysis, Automated gas control