linjc16/ctgov huggingface dataset:
Efficacy of Plyometrics to Increase Bone Mass in Men With Osteopenia

Study Overview
=================
Brief Summary
-----------------
This study will compare the ability of two types of long term (12 months) weight-bearing exercise treatments (1. high-intensity jumping and 2. weight lifting) to increase bone mass of the total body, spine and hip in physically active men with osteopenia.

Detailed Description
-----------------
The overall goal of this project is to determine the efficacy of chronic (12 months) plyometric jump training exercise on bone mineral density (BMD) and markers of bone turnover in physically active males cyclists diagnosed with osteopenia below normal bone mineral density of the lumbar spine or hip.

Official Title
-----------------
Efficacy of Plyometrics to Increase Bone Mass in Men With Osteopenia

Conditions
-----------------
Osteopenia

Intervention / Treatment
-----------------
* Other: resistance exercise
* Other: plyometric exercise


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Male Age 25-60 years No symptoms of disease Currently participating in cycling activities an average of 4 hr/wk for the previous 24 months Osteopenia of the lumbar spine and/or hip (T score < -1.0 and > -2.5 ) Exclusion Criteria: Medications or supplements that affect bone metabolism or prevent exercise Previous or current medical condition affecting bone health Osteoporosis of the lumbar spine and/or hip (T score > -1.0 or < -2.5) Cardiovascular disease Metallic implants Current smoker Current regular participation in high-intensity resistance training and/or plyometrics

Ages Eligible for Study
-----------------
Minimum Age: 25 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: resistance exercise<br>12 month resistance exercise training | Other: resistance exercise<br>* 12 month training intervention of weight resistance exercise. All participants receive a daily calcium and vitamin D supplement<br>|
| Experimental: plyometric exercise<br>12 month plyometric exercise training | Other: plyometric exercise<br>* 12 month training intervention of plyometric exercise. All participants receive a daily calcium and vitamin D supplement<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Bone Mineral Density |  | 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Serum markers of bone turnover |  | 3 months | 
| Serum hormones regulating bone turnover |  | 3 months |
Role for Biochemical Assays and Kayser-Fleischer Rings in Diagnosis of Wilson Disease

Study Overview
=================
Brief Summary
-----------------
The investigators aimed to identify factors associated with symptoms and features of Wilson disease from a large cohort during long-term follow-up

Detailed Description
-----------------
Wilson disease is an autosomal recessive disorder that impairs copper homeostasis and is caused by homozygous or compound heterozygous mutations in ATP7B, which encodes a copper-transporting P-type ATPase. Patients have variable clinical manifestations and laboratory test results, resulting in diagnostic dilemmas. Therefore, the investigators aimed to identify factors associated with symptoms and features of Wilson disease, thereby give timely diagnosis for patients.

Official Title
-----------------
Role for Biochemical Assays and Kayser-Fleischer Rings in Diagnosis of Wilson Disease

Conditions
-----------------
Wilson Disease

Intervention / Treatment
-----------------
* Dietary Supplement: low copper diet


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: genetically diagnosed patients with wilson disease Exclusion Criteria: Deny follow-up

Ages Eligible for Study
-----------------
Minimum Age: 6 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Wilson's disease cohort<br>Patients were clinically diagnosed according to the Leipzig Score and included in the study when they were confirmed to carry ATP7B pathogenic variants in 2 different alleles. | Dietary Supplement: low copper diet<br>* All patients with wilson disease should receive low copper diet<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Serum ceruloplasmin | Serum ceruloplasmin levels were collected among patients with wilson disease. After confirming a non-Gaussian distribution, the reference range of serum ceruloplasmin level was determined. | From 2004 through 2030 | 
| Urinary Copper Excretion | The measurement of 24-hour urine copper excretions were collected and measured. | From 2004 through 2030 | 
| Kayser-Fleischer Rings | The presence of Kayser-Fleischer Rings among patients with wilson disease were confirmed via slit lamp. | From 2004 through 2030 | 
| Brain Magnetic Resonance Imaging | Brain Magnetic Resonance Imaging of all patients were collected and analyzed. | From 2004 through 2030 |
The Effect of Ischemic Training on Exercise Endurance

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine if reducing blood flow to an exercising muscle during exercise training will enhance the training effect on that muscle in people who have limited exercise because of congestive heart failure

Detailed Description
-----------------
The objective of this study is to determine whether reduction of blood flow during stair-stepping and cycling ergometer leg exercise will contribute to an improvement in whole body exercise capacity or submaximal exercise endurance in patients with mild congestive heart failure. Two groups of 25 patients with mild to moderate CHF, aged 30-70, will be trained for 12 weeks. The experimental group will train with pressure cuffs inflated on one thigh and lower leg during exercise. The cuff will be applied on alternate legs during training, such that each leg has the same duration of ischemic training. The control group will train for a similar duration and intensity without pressure cuffs on the legs. Pre and post training measures will include VO2peak, exercise duration at 30% VO2peak, 6 minute walk test, Minnesota Living with Heart Failure questionnaire

Official Title
-----------------
The Effect of Ischemic Training on Exercise Endurance

Conditions
-----------------
Heart Failure, Congestive Heart Failure, Cardiovascular Disease

Intervention / Treatment
-----------------
* Procedure: Ischemic exercise training


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Mild Congestive Heart Failure Must be able to exercise Exclusion Criteria: Venous or arterial thrombus Lower extremity arthritis Blood clotting abnormalities Claudication Peripheral vascular disease Evidence of deep vein thrombosis on ultrasound

Ages Eligible for Study
-----------------
Minimum Age: 30 Years
Maximum Age: 71 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Ischemic exercise training|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Exercise duration before and after 12 weeks of training during a submaximal exercise test and distance walked on a 6-minute walk test. |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Peak cycle ergometer VO2max test before and after training |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Exercise, Exercise Therapy
Contingency Management for Persons With Severe Mental Illness

Study Overview
=================
Brief Summary
-----------------
Contingency management is efficacious for treating cocaine abuse, but contingency management interventions have rarely been applied to patients with severe and persistent mental health problems. This pilot project will estimate effect sizes of contingency management for reducing cocaine use in patients receiving psychiatric care at a large community based mental health program. In total, 30 cocaine abusing patients will be randomized to one of two 8-week treatment conditions: standard care or standard care with contingency management. Patients in both conditions will provide breath and urine samples for toxicology testing twice per week. In the contingency management condition, patients will receive the opportunity to win prizes for submitting cocaine negative urine samples. The investigators expect that patients receiving contingency management will evidence reductions in cocaine use and may show improvements in psychiatric symptoms and psychosocial functioning relative to patients in standard care. Effect size estimates obtained from this study will be used to guide larger scale and longer duration evaluations of contingency management for dually diagnosed patients.

Official Title
-----------------
Contingency Management for Persons With Severe Mental Illness

Conditions
-----------------
Substance Abuse

Intervention / Treatment
-----------------
* Behavioral: contingency management
* Other: Standard Care


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age 18 years or older meet DSM-IV criteria for cocaine abuse or dependence English speaking pass a brief quiz regarding study procedures to ensure understanding of the informed consent process. Exclusion Criteria: dementia in recovery from pathological gambling

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Standard Care<br> | Other: Standard Care<br>* Standard Care<br>|
| Experimental: Contingency management for abstinence from drugs<br> | Behavioral: contingency management<br>* Participants will receive the opportunity to win prizes for submitting cocaine negative urine samples.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| longest continuous period of cocaine abstinence |  | Week 8 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| other drug use and psychosocial problems |  | Week 8 |
Medicolegal Aspects of Head Trauma

Study Overview
=================
Brief Summary
-----------------
Trauma is a critical global health problem. It represents the fifth leading cause of significant disability and is one of the most common causes of mortality in youth and adulthood, as one in 10 deaths worldwide occurred due to trauma. The head is preferred target for criminal acts and is a favorite place for various pathological lesions .Traumatic head injury (THI)is one of the prevalent causes of global death and disability. lately, head injury (HI) cases have increased in both developed and developing nations. Therefore, it is of great value to evaluate the clinical and pathological features of head injury . Every injury that results in harm to the scalp, skull or brain can be sort out as a HI which can be caused by traffic mishap, falls, sports and gunshot wounds. Vehicle accidents are one of the most prevalence causes of THI as they are deemed to be one of the main causes of fatality due to road-traffic accidents (RTA) .Among different type of the RTA, motorcycle accidents holds the number one cause of accident in most of the country . Skull fracture and hemorrhage are common association, which may be present with head trauma and affect the outcome of the case.The skull fractures, especially by blunt force offer varying diagnostic and medico- legal problems to the medical jurists as well as to the clinicians.

Official Title
-----------------
Medicolegal Aspects of Head Trauma in Sohag University Hospitals

Conditions
-----------------
Head Trauma

Intervention / Treatment
-----------------
* Other: questionnaire


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosed cases of head trauma Exclusion Criteria: Patients with deficient data i.e. escaped, discharged on demand before period of follow up

Ages Eligible for Study
-----------------
Minimum Age: 1 Day

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: questionnaire|Patient demographic data ( age, gender, residence , work ,Level of education) .Detailed history about the trauma (type, site , manner , mechanism of injury , actual cause of assault , post traumatic period till arrival to hospital ) .Clinical assessment ( Rapid neurological assessment , assesment of Scalp injury ,Presence of other body trauma ,Degree of severity of head injury according to GCS , Radiological finding. Treatment (Conservative or operative intervention ) .Follow up and outcome at the time of discharge by using the GOS .Expected time for healing (<20 day or >20 day ).Expectance for permanent infirmity|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The aim of the current study is to assess and describe the change in the medicolegal aspects of traumatic head injuries in sohag university hospital | Expected time for healing and expectance for permanent infirmity | 1year |
Suture Granuloma in Body Contouring Surgery

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate the effect of different suture material on the incidence of suture granuloma.

Detailed Description
-----------------
Bariatric surgery has evolved as an effective treatment for morbid obesity, inducing rapid and predictable weight loss within a period of 12 to 18 months following surgery. Consequently, body contouring after weight loss is emerging as the fastest growing field of plastic surgery. Patients seek consultation with a plastic surgeon to correct skin laxity of the abdomen, thighs, chest, back, and neck. A major problem in body contourinig is the extrusion of absorbable suture material used for dermal closure. Long incisions and high tension inherent to body contouring surgery mandate a secure dermal closure. While absorbable sutures are preferred, they can result in suture granuloma and extrusion.

Conditions
-----------------
Skin Laxity of Abdomen, Thighs, Chest, Back, and Neck

Intervention / Treatment
-----------------
* Device: Absorbable sutures


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Men and women 18 years and older Exclusion Criteria: Subjects with active infectious collagen disease,significant anatomic asymmetry that creates markedly different wound tension and/or geometry between left and right side Subjects who cancel their surgery

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: Absorbable sutures|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
bariatric surgery, body contouring, skin laxity, plastic surgery, suture granuloma, absorbable sutures
Medical College of Georgia FitKid Project

Study Overview
=================
Brief Summary
-----------------
This project will determine whether exposing youths to a fitogenic after-school environment that emphasizes vigorous exercise and healthy snacks will have a favorable effect on body composition (i.e., less fat tissue and more lean tissue), cardiovascular fitness and cardiovascular disease risk profile. The environmental intervention will be provided in nine schools in Augusta, Georgia, with another nine schools serving as non-intervention comparison schools. Children in the 3rd grade will be recruited to participate. They will be followed for 3 years, through the 5th grade. Measurements will be made at the beginning and end of each school year. The 2-hour after-school intervention will be offered every school day. It will consist of three components: (1) homework assistance; (2) a healthy snack; and (3) exercise designed to improve skills and fitness.

Conditions
-----------------
Healthy

Intervention / Treatment
-----------------
* Behavioral: exercise


Participation Criteria
=================
Eligibility Criteria
-----------------
3rd graders in schools chosen to participate.

Ages Eligible for Study
-----------------
Minimum Age: 8 Years
Maximum Age: 9 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment


Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: exercise|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Post-marketing Surveillance of Atrovent® Inhalets in Chronic Obstructive Pulmonary Disease

Study Overview
=================
Brief Summary
-----------------
Study to obtain further information on the tolerability and efficacy of Atrovent® inhalets in the treatment of Chronic Obstructive Pulmonary Disease under conditions of daily practice

Official Title
-----------------
Post-marketing Surveillance (as Per § 67(6) AMG [German Drug Law]) of Atrovent® Inhalets in Chronic Obstructive Pulmonary Disease

Conditions
-----------------
Pulmonary Disease, Chronic Obstructive

Intervention / Treatment
-----------------
* Drug: Atrovent® - inhalets


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients of both genders older than 40 years, who suffer from Chronic Obstructive Pulmonary Disease Only patients who have not been treated with Atrovent® within the last year are to be considered for inclusion Exclusion Criteria: Contraindications listed in the Instructions for Use/Summary of Product Characteristics for Atrovent® metered dose inhaler

Ages Eligible for Study
-----------------
Minimum Age: 40 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Chronic obstructive pulmonary disease patients<br> | Drug: Atrovent® - inhalets<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in overall severity of the clinical picture |  | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Assessment of efficacy by investigator on a 4-point scale |  | after 3 months | 
| Assessment of efficacy by patient on a 4-point scale |  | after 3 months | 
| Number of patients with adverse drug reactions |  | 3 months | 
| Assessment of tolerability by investigator on a 4-point scale |  | after 3 months | 
| Assessment of tolerability by patient on a 4-point scale |  | after 3 months |
Community-based Microalbuminuria Screening in Patients With Hypertension

Study Overview
=================
Brief Summary
-----------------
This study evaluates the effectiveness of different anti-hypertensive drugs on patients with hypertension and microalbuminuria.

Detailed Description
-----------------
This is a a real world registry study. All patients with hypertension in community hospitals in China will be eligible . Patient demographics, medical history, clinical characteristics, physical examination, laboratory tests (including UCAR, blood routine, urine routine, blood biochemistry, and ECG), antihypertensive drugs (including: ACEI/ ARB, thiazide diuretics, CCB, beta-blockers, alpha-blockers, and other antihypertensive drugs used in real-life clinical practice in other communities.) will be recorded. All patients are anticipated to be followed up for 12-month. Effectiveness of different antihypertensive medications on Urine Albumin-to-Creatinine Ratio (UACR) will be evaluted.

Official Title
-----------------
Effectiveness of Different Antihypertensive Medications on Urine Albumin-to-Creatinine Ratio (UACR) in Community Hypertensive Patients With Microalbuminuria

Conditions
-----------------
Hypertension, Microalbuminuria

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with essential hypertension; Urinary albumin/creatinine ratio in random urine samples is 30-300 mg/g Age >=18 Understand and sign informed consent Exclusion Criteria: This is a real-world registry study and does not set exclusion criteria

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Urine Albumin-to-Creatinine Ratio (UCAR) | Differences in UCAR between with ACEI/ARB and without ACEI/ARB | 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Combined endpoints: re-admission, cardiovascular events, and all-cause mortality | Differences in Combined endpoints between with ACEI/ARB and without ACEI/ARB | 12 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Hypertension, Microalbuminuria, Effectiveness, Antihypertensive medications