Extracorporal Membrane Oxygenation for Critically Ill Patients With COVID-19

Study Overview
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Brief Summary
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Retrospective single center analyses of COVID-19 patients admitted to the ICU between 01/02/2020 and 31/07/2021.

Detailed Description
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All adults (>18 years) with acute hypoxaemic respiratory failure due to diagnosed COVID-19 pneumonia and admitted to ICU from 01/02/2020 until 31/07/2021 were included in the study. Following the World Health Organisation (WHO) protocol 19, laboratory confirmation of COVID-19 infection was defined as a positive result on polymerase chain reaction (PCR) assays of nasopharyngeal swab samples or bronchoalveolar lavage. Only laboratory-confirmed patients were included in the analysis. Additional data collection Additional collected parameters are listed below and are collected as a standard-of-care in our hospital: Demographics: i.e age, gender, BMI DNR code Comorbidities: smoking, obesity, hypertension, diabetes, cardiovascular disease, respiratory disease, malignancies, renal failure (AKI), liver failure, gastrointestinal disease, neurological conditions, mental state, other Symptoms at the time of admission to ICU: i.e fever, body temperature, dyspnoea, headache, diarrhea etc… Laboratory results of all standard parameters measured Treatment: antiviral agents, antibiotics, etc… Complications: shock, heart failure, sepsis, stroke, etc… Ventilation: method, PEEP, FiO2, P/F ratio ..

Official Title
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Extracorporal Membrane Oxygenation for Critically Ill Patients With COVID-19: a Single Centre Analysis

Conditions
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COVID-19

Intervention / Treatment
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* Procedure: ECMO


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All adult COVID-19 patients (>18 years) admitted to the ICU between 01/02/2020 and 31/07/2021 with a laboratory confirmation of COVID-19 infection with a positive result on polymerase chain reaction (PCR) assays of nasopharyngeal swab samples or bronchoalveolar lavage Exclusion Criteria: All adult patients admitted for other reasons to the ICU (no COVID-19 pneumonia)

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| COVID-19 patients<br>COVID-19 patients admitted to the ICU | Procedure: ECMO<br>* Patients undergoing extracorporeal membrane oxygenation<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality | mortality of patients during their stay at the ICU | through study completion, an average of 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 3 Months Mortality | Mortality of patients | 3 months after admission to ICU | 
| acute kidney injury | incidence of acute kidney injury | through study completion, an average of 1 year | 
| continous renal replacement therapy | incidence of continous renal replacement therapy | through study completion, an average of 1 year | 
| Length of stay in hospital | Length of stay in hospital | through study completion, an average of 1 year | 
| Length of stay in ICU | Length of stay in ICU | during ICU stay | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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ECMO