linjc16/ctgov huggingface dataset:
Benign Thyroid Nodules / Benign Goiter. What Subjective Problems Are Improved With an Operation and Can This be Predicted Preoperatively?

Study Overview
=================
Brief Summary
-----------------
Nodules in the thyroid gland are common. Patients discover these lumps either because of their visible size increase or because of local discomforts such as difficulty swallowing, difficulty breathing or voice changes. The thyroid gland is in close connection with the esophagus, trachea and the vocal nerve. Thus, a lump in the thyroid gland can cause pressure symptoms from these organs. In the event of such complaints, patients are referred for investigation. If it turns out that the patient has a lump in the thyroid gland (goiter), further investigation is carried out with an ultrasound examination and sampling with a needle from the lump (puncture). At present, most thyroid nodules are examined cytologically, ie the thyroid nodules are punctured with a thin needle and the cells that are obtained are analyzed by a cytologist. The material is graded according to Bethesda classification. Higher grading is associated with a higher risk that the tuber is malignant. Lower grading is associated with a lower probability that the tuber can be malignant. If these patients are operated on, it is usually with the hope that their local ailments improve. We want to investigate which patients who have a lump in the thyroid gland and experience pressure problems experience an improvement after a thyroid operation.

Official Title
-----------------
Benign Thyroid Nodules / Benign Goiter. What Subjective Problems Are Improved With an Operation and Can This be Predicted Preoperatively?

Conditions
-----------------
Thyroid Nodule

Intervention / Treatment
-----------------
* Procedure: Hemithyroidectoy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with a thyroid nodule who have local problems and where surgery (hemithyroidectomy) is planned 18 years or older Bethesda I-IV Exclusion Criteria: -

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Hemithyroidectoy|Hemithyroidectomy it is a surgical procedure where half of the thyroid gland is operated.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Symptom improvement | Which sypmtoms become better after hemithyroidectomy | One year follow upp | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparision of questionnaries | The patients are going to fill in 4 different questionnaries in 3 different time intervalls. Before the operation, 1 month and 1 year efter the operation. | 2024 |
Use of the WALANT Anesthesia Technique for Forefoot Surgery.

Study Overview
=================
Brief Summary
-----------------
To compare the perioperative pain level with WALANT anesthesia versus general anesthesia during forefoot surgery.

Detailed Description
-----------------
Orthopaedic foot and ankle surgery is typically performed while the patient is under general or regional anesthesia. The Wide Awake Local Anesthesia No Tourniquet (WALANT) technique is a local anesthesia technique used since 1980s in Canada for hand surgery. WALANT uses a combination of a local anesthetic and vasoconstrictor to induce anesthesia and hemostasis in the area of the surgical procedure in order to allow surgeries to be done without the use of tourniquet. This practice eliminates the need for the tourniquet due to the hemostatic effect of the vasoconstrictor. The administration of the local anesthetic is done as close as possible to the surgical site, which allows the mobility of the joint to be maintained, while having complete anesthesia. The retention of mobility and the absence of a tourniquet improve patient comfort. The main objective of this prospective study is to evaluate the perioperative pain level with WALANT anesthesia compared to general anesthesia during forefoot surgery.

Official Title
-----------------
Use of the WALANT Anesthesia Technique for Forefoot Surgery.

Conditions
-----------------
Orthopedic Disorder

Intervention / Treatment
-----------------
* Procedure: Anesthesia


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patient, male or female, over 18 years of age Patient with scheduled forefoot surgery Exclusion Criteria: Protected patient : major under guardianship, tutorship or other legal protection, deprived of liberty by judicial or administrative decision Pregnant or breastfeeding woman

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group with general anesthesia performed during the forefoot surgery<br> | Procedure: Anesthesia<br>* 2 types of anesthesia (general and WALANT) performed during the surgery<br>|
| Group with WALANT anesthesia performed during the forefoot surgery<br> | Procedure: Anesthesia<br>* 2 types of anesthesia (general and WALANT) performed during the surgery<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain assessment | Measure of the pain using the VAS pain scale. | Perioperative |
A Validation/Interventional Study on Stress Index in Predicting Mechanical Stress in ARDS Patients

Study Overview
=================
Brief Summary
-----------------
30% of ARDS patients ventilated according to NIH protocol presents CT scan evidence of hyperinflation. Functional analysis of pressure-time curve (Stress Index=SI) has been shown to identify this condition in experimental settings. We tested the hypothesis that the SI is an accurate predictor of mechanical stress due to overdistention in ARDS patients.

Detailed Description
-----------------
The study presents two parts : a preliminary validation study and a clinical study.

Conditions
-----------------
Respiratory Distress Syndrome, Adult

Intervention / Treatment
-----------------
* Procedure: Change ventilatory parameters with stress index monitoring


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age ≥ 18 years Diagnosis of ARDS based on American-European Consensus Conference criteria Exclusion Criteria: >3 days since ARDS criteria were met and mechanical ventilation was started History of ventricular fibrillation or tachyarrhythmia, unstable angina or myocardial infarction within preceding month Pre-existing chronic obstructive pulmonary disease Major chest wall abnormalities Chest tube with persistent air leak Abdominal distension Body mass index >30 Pregnancy Known intracranial abnormality Enrollment in another interventional study

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Change ventilatory parameters with stress index monitoring|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| reduction of pulmonary inflammatory mediators |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
ARDS, Pressure/time curve, Stress Index
To Evaluate the Treatment Effect of an Anti-Infective Agent for Complicated Infections (0826-053)

Study Overview
=================
Brief Summary
-----------------
To collect clinical response data with the use of ertapenem in community acquired sepsis.

Official Title
-----------------
An Open-Label, Single-Arm, Non-Comparative Study to Evaluate the Efficacy, Tolerability & Convenience of Invanz(TM) (Ertapenem Sodium) In the Treatment of Community-Acquired Sepsis in Adults

Conditions
-----------------
Sepsis

Intervention / Treatment
-----------------
* Drug: MK0826, ertapenem sodium / Duration of Treatment: 14 Days


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Male or female patients, 18 years of age or older Patients present with at least two of the following signs and symptom: fever (temperature> 38c or < 36c) heart rate > 90 beats/min) respiratory rate> 20 breaths/min) high white blood cell count > 12,000/ul or >10% bands) Exclusion Criteria: Patient has a history of allergy or hypersensitivity (anaphylaxis) or serious adverse reaction to ertapenem or any carbapenem Patient has a poor chance of survival for more than 14 days. Patient has an apache ii score > 15 (see attachment 3. Patient has an infection caused by pathogens resistant to ertapenem The patient requires antibiotics other than ertapenem (such as: glycopeptides, macrolides or antifungal agents)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: MK0826, ertapenem sodium / Duration of Treatment: 14 Days|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Signs and symptoms of infection on days 3, 4, 7 and 14 during treatment |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Safety and Tolerability |  |  |
Exercise Training After Transcatheter Aortic Valve Implantation

Study Overview
=================
Brief Summary
-----------------
This pilot study will evaluate the effect of a rehabilitative exercise training on exercise capacity in patients after percutaneous aortic valve replacement. It will additionally evaluate the safety of such an approach and the effect on life quality. We hypothesize that regular structured exercise improves exercise capacity in these patients beyond the sole effect of the valve procedure.

Detailed Description
-----------------
The study will include 30 patients and randomize them in a 1:1-fashion to either a training or a usual care group. The training group will undergo 8 weeks of combined endurance and resistance training according to a standard protocol, but with individual adjustment if required. The usual care group will receive general advice but no structured exercise program. Exercise capacity is assessed by cardiopulmonary exercise testing and by the 6 minute walk test prior to and after the intervention period. In addition, life quality will be assessed by validated questionnaires, while safety will be assessed by recording adverse events and by echocardiography.

Official Title
-----------------
Safety, Applicability and Outcome of Regular Exercise Training After Transcatheter Aortic Valve Implantation

Conditions
-----------------
Transcatheter Aortic Valve Replacement

Intervention / Treatment
-----------------
* Behavioral: Exercise


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients up to 6 months after transcatheter aortic valve implantation Exclusion Criteria: inability to perform exercise on bicycles valve dysfunction
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Exercise<br>8 weeks of supervised, structured, combined endurance and resistance training | Behavioral: Exercise<br>* endurance and resistance exercise 3x/week for 8 weeks<br>|
| No Intervention: Control<br>Patients receive usual care, regular exercise is not recommended but also not prohibited | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of peak oxygen uptake |  | Baseline to 8 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of quality of life | Assessed by SF-12 and KCCQ questionnaires | Baseline to 8 weeks |
Total Knee Arthroplasty Analgesia: Single-shot Femoral Nerve Block or Epidural?

Study Overview
=================
Brief Summary
-----------------
Single-shot femoral nerve block is similar to continuous epidural technique for postoperative analgesia in total knee arthroplasty

Official Title
-----------------
Comparison Between Single-shot Femoral Nerve Block and Epidural Techniques for Total Knee Arthroplasty: a Randomized Controlled Trial

Conditions
-----------------
Postoperative Pain Treatment for Total Knee Arthroplasty

Intervention / Treatment
-----------------
* Drug: Ropivacaine perineural injection
* Drug: morphine and ropivacaine


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Elective total knee arthroplasty Exclusion Criteria: Coagulopathy Neuropathy Morbid obesity local anesthetics allergy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Single-shot nerve block<br>Efficacy compared to epidural | Drug: Ropivacaine perineural injection<br>* Ultrasound guided single-shot femoral nerve block<br>|
| Active Comparator: Continuous epidural<br>Continuous epidural perfusion | Drug: morphine and ropivacaine<br>* Continuous epidural analgesic perfusion Epidural perfusion with morphine and ropivacaine.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain Score on the numeric pain score | Patients will be evaluated at 48 hours. At these time frame pain score at rest and during movement will be accessed. | 48 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Side effects as a measure of safety and tolerability | Side effects of both interventions. Number of patients with side effects like nausea, vomiting, hypotension and pruritus. | 48 hours | 
| Rescue analgesic consumption. | Opioid rescue needs in the first 48 hours after surgery. | 48 hours | 
| Patients satisfaction. | Evaluation of patient´s satisfaction with pain control (asking the patient to classify the grade of satisfaction). | 48 hours |
Effect of Strategy for Blood Pressure Control on Cerebral Oxygen Balance During Aortic Coarctation Repair: A Randomized Study

Study Overview
=================
Brief Summary
-----------------
In a prospective and randomized study protocol, three different blood pressure regulating agents (nitroprusside, nitroglycerine, sevoflurane) will be compared concerning their effect on the cerebral oxygen balance between both hemispheres during aortic coarctation repair. Cerebral and somatic saturation will be monitored non-invasively and continuously via optical sensors applied to the right and left forehead and the somatic regions. Arterial blood pressure, central venous pressure, heart rate and systemic saturation will be recorded continuously. Intermittently, arterial and venous blood gas analysis will be performed at 6 definite time intervals. The study ends at the end of the operation.

Official Title
-----------------
Effect of Strategy for Blood Pressure Control on Cerebral Oxygen Balance During Aortic Coarctation Repair: a Randomized Study

Conditions
-----------------
Cerebral Oxygenation

Intervention / Treatment
-----------------
* Drug: nitroprusside
* Drug: nitroglycerine
* Drug: sevoflurane


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All neonates and infants Aged 0-18 year With aortic coarctation requiring surgical correction without the additional use of cardiopulmonary bypass will be included. Exclusion Criteria: All patients with an associated cardiac effect are excluded.

Ages Eligible for Study
-----------------
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>Administration of nitroprusside | Drug: nitroprusside<br>* Administration of nitroprusside<br>|
| Experimental: 2<br>Administration of nitroglycerine | Drug: nitroglycerine<br>* Administration of nitroglycerine<br>|
| Experimental: 3<br>Administration of sevoflurane | Drug: sevoflurane<br>* Administration of Sevoflurane<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cerebral saturation |  | During operation |
Ultrasound as a Diagnostic Tool for Rotator Cuff Tears

Study Overview
=================
Brief Summary
-----------------
After comparing ultrasound study of rotator cuff injuries that have been evaluated both in the community and in a hospital-based ultrasound service with actual surgical findings, it is expected that specialist performed imaging and evaluation will be most accurate and that those performed in the community will be not accurate enough.

Official Title
-----------------
Ultrasound as a Diagnostic Tool for Rotator Cuff Tears: Accuracy of Results From the Community Versus Results From a Hospital-based Ultrasound Service and Surgical Findings

Conditions
-----------------
Rotator Cuff Tear

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Symptomatic rotator cuff tears Indication for rotator cuff repair Exclusion Criteria: Severe arm movement limitations
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Symptomatic rotator cuff tear<br>Patients with symptomatic rotator cuff tears presenting to hospital clinic after having ultrasound exam in community with indications for surgery | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rotator cuff tear surgical findings more accurately reflect hospital-based US imaging findings |  | One year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Accuracy of diagnostic ultrasound based in community or as part of a specialist hospital-based service
Perception, Cognition, and Gait in Parkinson's Disease

Study Overview
=================
Brief Summary
-----------------
The investigators are examining how aspects of daily function are perceived in persons with PD and in those who interact with them on a regular basis. If eligible, participants will receive a set of online questionnaires by email. The questionnaires will take about 1 hour to complete, and can be done at the participant's convenience. The investigators are looking for volunteers who have a diagnosis of Parkinson's disease without dementia (age 40 or older and proficient English speakers). If a spouse, family member, significant other or other close associate is available (age 18 or older, proficient English speakers), the investigators will send them questionnaires as well. There is no monetary or other compensation for this study. For more information, please contact the Vision and Cognition Laboratory at vcognition@gmail.com or 617-358-1377.

Official Title
-----------------
Perception, Cognition, and Gait in Parkinson's Disease

Conditions
-----------------
Parkinson Disease

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosed with Parkinson's disease without dementia OR close associate of someone with Parkinson's disease 40 years or older Proficient English speaker Access to a computer 8+ years of education Exclusion Criteria: Co-existing active neoplasm, serious cardiac disease, other serious chronic medical illness Prior intracranial surgery History of traumatic brain injury Psychiatric or neurological diagnoses other than Parkinson's disease History of alcoholism or other drug abuse History of treatment with electroshock therapy

Ages Eligible for Study
-----------------
Minimum Age: 40 Years
Maximum Age: 100 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| People with Parkinson's Disease<br>Individuals diagnosed with idiopathic Parkinson's disease without dementia. | |
| Informant<br>Family member, spouse, significant other, caregiver, or other close associate of someone with Parkinson's disease. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Parkinson's Disease Questionnaire (PDQ-39) | Measures the health status of Parkinson's disease patients and the impact the disease has on their aspects of daily living. There are 39 items. | Within 24 hours of starting the study | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Parkinson's Disease, Online Study, Quality of Life, Activities of Daily Living, Perception, Cognition, Gait