Benefits of Breast MRI for Predicting of Histopathologic Cell Type of Small Breast Cancer

Study Overview
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Brief Summary
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This study examines the additional benefits of magnetic resonance imaging (MRI) with Gadovist in early breast cancer with poor prognostic features.

Detailed Description
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Dedicated Contrast-enhanced Magnetic Resonance Imaging (DCE-MRI)

Official Title
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Accuracy of Magnetic Resonance Imaging (MRI) in Predicting Aggressiveness of Early Breast Cancer According to Molecular Subtypes Identified by ER PR and HER-2 Status

Conditions
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Invasive Breast Cancer

Intervention / Treatment
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* Radiation: MRI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with invasive ductal carcinoma Patients undergoing DCE-MRI scan which are assessed according to BI-RADS lexicon Breast cancer patients with pathological diagnosed invasive ductal carcinoma with hormonal receptor (ER, PR and HER-2) response Patients who have signed on informed consent form Patients will undergo MRI imaging and the physicians will practice according to practice guidelines. Exclusion Criteria: Patients under 18 years old or during pregnancy Patients with MRI's contraindications e.g. patients with cardiac pacemaker or are allergic to MRI contrast agent Patients with unstable clinical abnormality and might get unexpected clinical treatment

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: No treatment<br>Accuracy of magnetic resonance imaging (MRI) in predicting aggressiveness of early breast cancer according to molecular subtypes identified by ER PR and HER-2 status ( Additional benefits of magnetic resonance imaging (MRI) with Gadovist in early breast cancer with poor prognostic features ) | Radiation: MRI<br>* magnetic resonance imaging (MRI) with Gadovist in early breast cancer with poor prognostic features<br>* Other names: Magnetic Resonance Imaging;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| study the benefits of DCE-MRI using Gadovist in prognostic determination of early invasive breast cancer | The benefits of breast tumor diagnosis from DCE-MRI in early invasive breast cancer with poor prognostic features | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| ascertain the accuracy of pre-operative DCE-MRI in terms of detection and characterization of breast cancer, as compared to tissue biopsy. | The comparision between DCE-MRI radiological features in early invasive breast cancer with poor prognostic features and early invasive breast cancer with good prognostic features To ascertain the accuracy of pre-operative DCE-MRI in terms of detection and charecterization of breast cancer, as compared to tissue biopsy | 1 year |