The Relationship Between Zonulin and Interleukin-8 Levels and Postoperative Delirium Development

Study Overview
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Brief Summary
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The relationship between zonulin and interleukin-8 levels and postoperative delirium development in patients who had femur fracture surgery under regional anesthesia

Detailed Description
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Patients who are over 65 years of age and scheduled for femur fixation surgery will be included in the study. Blood samples for zonulin and interleukin-8 levels will be taken at the day prior to the surgery. All patients will be evaluated by Delirium Rating Scale (DRS) for delirium development at the postoperative 1., 2. and 3. days. Patients with a DRS score over 14 points will be included in the Group Delirium. And second blood samples for zonulin and interleukin-8 levels will be taken at the time of diagnosis. Postoperative pain scores of the patients will recorded by using a numerical rating scale (NRS).

Official Title
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The Relationship Between Zonulin and Interleukin-8 Levels and Postoperative Delirium Development in Patients Who Had Femur Fracture Surgery Under Regional Anesthesia

Conditions
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Postoperative Delirium

Intervention / Treatment
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* Diagnostic Test: Evaluation of Delirium development


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients over 65 years with mini mental state score > 21, undergoing femur fixation surgery Exclusion Criteria: anticholinergic drug use, known epilepsy, Parkinson, Alzheimer's disease, dementia, cognitive function disorder

Ages Eligible for Study
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Minimum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| group delirium<br>Patients who are over 65 years of age and scheduled for femur fixation surgery will be included in the study. Blood samples for zonulin and interleukin-8 levels will be taken at the day prior to the surgery. All patients will be evaluated by Delirium Rating Scale for delirium development at the postoperative 1., 2. and 3. days. Patients with a Delirium Rating Scale score over 14 points will be included in the Group Delirium. And second blood samples for zonulin and interleukin-8 levels will be taken at the time of diagnosis. Postoperative pain scores of the patients will recorded by using a numerical rating scale. | Diagnostic Test: Evaluation of Delirium development<br>* Postoperative pain scores of the patients will recorded by using a numerical rating scale.<br>* Other names: Postoperative pain evaluation;|
| group control<br>Patients who are over 65 years of age and scheduled for femur fixation surgery will be included in the study. Blood samples for zonulin and interleukin-8 levels will be taken at the day prior to the surgery. All patients will be evaluated by Delirium Rating Scale for delirium development at the postoperative 1., 2. and 3. days. Patients with a Delirium Rating Scale score under 14 points for postoperative 72 hours will be included in the Group Control. And second blood samples for zonulin and interleukin-8 levels will be taken at the postoperative 72. hour. Postoperative pain scores of the patients will recorded by using a numerical rating scale. | Diagnostic Test: Evaluation of Delirium development<br>* Postoperative pain scores of the patients will recorded by using a numerical rating scale.<br>* Other names: Postoperative pain evaluation;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| preoperative Zonulin | The relation between postoperative delirium development and preoperative blood zonulin levels. The correlation between them will be analyzed by statistical analysis. | in the preoperative 24. hour | 
| postoperative Zonulin | The relation between postoperative delirium development and postoperative blood zonulin levels The correlation between them will be analyzed by statistical analysis. | At the postoperative 72. hour | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| preoperative Interleukin-8 | The relation between postoperative delirium development and preoperative blood interleukin-8 levels. The correlation between them will be analyzed by statistical analysis. | in the preoperative 24. hour | 
| postoperative Interleukin-8 | The relation between postoperative delirium development and postoperative blood interleukin-8 levels. The correlation between them will be analyzed by statistical analysis. | At the postoperative 72. hour |