Evaluation of Copeptin Levels in Elective Cesarean Section With Different Anesthetic Technique

Study Overview
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Brief Summary
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In this study, investigators aimed to investigate the effects of general and spinal anesthesia techniques on copeptin levels during cesarean section and their relation with fetal distress.

Detailed Description
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During the delivery process, the mother and the baby generate some endocrine responses to this emotional and physical stressful action. Arginin-Vasopressin prohormone (copeptin), which is more stable and measurable in blood, is used as an endogenous stress indicator. Copeptin levels have been shown to be significantly increased in vaginally delivery when compared to cesarean section (c / s). In a caesarean section; it is a known fact that when the general anesthetic method and the used anesthetic substances are taken into consideration, it gives a significant stress to the mother and the baby. Spinal anesthesia with no impaired fetal oxygenation and without orotracheal intubation and neuromuscular blockers may reduce fetal distress. However, there was no study investigating the effect of the anesthesia techniques in elective cesarean section on the fetal stress and the level of copeptin, in the literature review. Therefore investigators aimed to compare spinal and general anesthesia technique in elective cesarean section, to evaluate level of copeptin and their relation with fetal distress.Investigators hope that this study will guide the anesthesia method that can be chosen primarily in caesarean section.

Official Title
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Evaluation of Copeptin Levels in Elective Cesarean Section With Spinal and General Anesthesia and Their Relationship With Fetal Stress: Prospective Study

Conditions
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Fetal Distress

Intervention / Treatment
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* Other: Copeptin


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 18-40 years of age ASA I-II 36-40 gestational weeks BMI ≤ 40 Undergoing elective cesarean section Exclusion Criteria: Coagulopathy Known central or peripheral nerve disease fetal anomalies birth weight less than 2000 grams and above 4500 grams, infants with a risk of meconium or amniotic fluid aspiration kidney failure, diabetes mellitus, hypertension, cardiac disease, antepartum hemorrhage, asthma bronchiole, Rh incompatibility, congenital malformations

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: General anesthesia<br> | Other: Copeptin<br>* Level of copeptin in maternal blood and umbilical cord blood<br>* Other names: Fetal distress;|
| Other: Spinal anesthesia<br> | Other: Copeptin<br>* Level of copeptin in maternal blood and umbilical cord blood<br>* Other names: Fetal distress;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in copeptin levels after general or spinal anesthesia |  | Baseline and immediately after surgery from maternal blood and arterial and venous umbilical cord at birth | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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copeptin levels, Cesarean section, general anesthesia, spinal anesthesia