An Open-Label Phase-1 Study of OPB-31121 in Patients With Advanced Solid Tumors

Study Overview
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Brief Summary
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This is an open-label, non-randomized, single-center, dose-escalation study in patients with advanced solid tumors. Six dose levels (100, 200, 400, 600, 800, and 1000 mg/day) are planned for the study. In this study, OPB-31121's potential for toxic effects will be evaluated in patients with advanced solid tumors to evaluate the recommended dose for use in subsequent studies. The pharmacokinetics and antitumor effect of the compound will also be investigated.

Official Title
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A Phase 1, Open-Label, Non-Randomized Study of OPB-31121 in Patients With Advanced Solid Tumors

Conditions
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Solid Tumor

Intervention / Treatment
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* Drug: OPB-31121


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria Histologically confirmed solid tumor refractory to standard therapy or for which there is no standard therapy Age: more than 19 years ECOG performance status: less than 2 Life expectancy of longer than 3 months Adequate vital organ function as follows: Bone marrow function neutrophils: more than 1,500 per microliter platelets: more than 75,000 per microliter hemoglobin: more than 10.0g per deciliter Hepatic function AST and ALT: less than 2.5 x institutional upper limit normal serum total bilirubin: less than 2.5 x institutional ULN Renal function Serum creatinine: less than 1.5 x institutional ULN Capable of swallowing OPB-31121 tablets Ability to understand and willingness to sign written informed consent document for participation in the trial and for analysis of genotypes CYP2C9 and NAT2 No chemotherapy, radiotherapy, surgery, or immunotherapy within 4 weeks prior to study entry and recovered from any prior toxicity Exclusion criteria: Symptomatic CNS metastasis Uncontrolled concurrent illness, including active infection, heart failure, angina pectoris, and cardiac arrhythmia Psychiatric illness that would limit compliance with study requirements Pregnant or breast-feeding women and women of childbearing potential who cannot or will not use effective contraceptive measures Administration of another investigational agent within 6 months prior to study entry Use of CYP3A4 and CYP2C9 inducers, inhibitors, or substrates, and CYP2B6, CYP2C8 and CYP2D6 substrates Hyperlipidemia: Total cholesterol:more than 300 milligram per deciliter or Triglycerides: more than 2.5 x institutional ULN Abnormal thyroid function: Hypothyroidism or hyperthyroidism of grade 2 or higher (graded according to the NCI-CTCAE)

Ages Eligible for Study
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Minimum Age: 19 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: OPB-31121|100mg tablet oral administration, Qd|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Maximum tolerated dose |  | Cycle 1 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Safety and dose-limiting toxicity |  | Duration of Study | 
| Pharmacokinetics |  | Cycle 1 | 
| Antitumor effect |  | Duration of study |