Sweet Taste Responsiveness in Relation to Insulin, Leptin and Adiposity Among Obese Treatment Seeking Children

Study Overview
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Brief Summary
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This study will explore whether a relationship exists between insulin and leptin resistance, sweet taste responsiveness, and adiposity.

Detailed Description
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Compared to healthy weight peers, some reports have shown that they are less sensitive to, or perceptive of, sucrose solutions and sweet foods, whereas others have observed the opposite pattern of findings or no difference at all. Among those seeking weight loss treatment, one investigation found perception and preferences for sweet taste remained unchanged after weight loss, and another observed a decreased ability to distinguish sweet taste from other taste solutions. Given these discrepancies in the literature, the proposed study will explore whether a relationship exists between insulin and leptin resistance, sweet taste responsiveness, and adiposity.

Official Title
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Sweet Taste Responsiveness in Relation to Insulin, Leptin and Adiposity Among Obese Treatment Seeking Children

Conditions
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Pediatric Obesity

Intervention / Treatment
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* Diagnostic Test: Serum insulin level
* Diagnostic Test: Serum Leptin test


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient of Children's Healthy Weigh of Buffalo ages of 8-14 If enrolled in the bariatric arm: • must be scheduled for bariatric surgery prior to enrollment Exclusion Criteria: Patients unable to get labs drawn at a Kaleida facility Severe hay fever or seasonal allergies within 2 weeks of enrollment smoker or are exposed to second-hand smoke at home, has been dieting to lose weight within the past 6 months of enrollment currently taking any prescription medications that can influence taste or small functions or are pregnant. pregnancy Bariatric arm patients will be excluded if they fail to have the surgery.

Ages Eligible for Study
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Minimum Age: 8 Years
Maximum Age: 14 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Compare the level of insulin, leptin, and sweet taste sensitivity and perception before and after short term weight loss and bariatric surgery
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Weight loss with bariatric surgery<br>Patients scheduled to undergo bariatric surgery will be tested pre and post bariatric surgery. Interventions to be measured are serum Insulin and leptin levels, sweet taste responsiveness, body fat percentage, and z-BMI | Diagnostic Test: Serum insulin level<br>* Measure levels before and after weight loss related to bariatric surgery<br>|
| Active Comparator: Weight Loss<br>Patients to receive lifestyle weight loss treatment will be tested pre and post bariatric surgery. Interventions to be measured are serum Insulin and leptin levels, sweet taste responsiveness, body fat percentage, and z-BMI | Diagnostic Test: Serum Leptin test<br>* Measure levels before and after weight loss related to lifestyle change weight loss<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Higher insulin and leptin levels will be associated with lower sweet taste sensitivity and perception, and higher body fat percentage and z-BMI | insulin and leptin levels will be measured at various time points in an attempt to identify if there is a change is taste senses associated with specific variables be associated with lower sweet taste | to be measured at 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Leptin, Insulin, Sweet Responsiveness, Weight Loss