Alzheimer's Disease Core Center

Study Overview
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Brief Summary
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The main objective of this research project is to provide a comprehensive clinical database of patients with Alzheimer's disease (AD) and other forms of dementia, individuals with mild cognitive impairment (MCI), and age-matched normal controls. The study will also attempt to identify cognitively normal individuals at genetically defined risk for Alzheimer's disease through genetic screening. All participants are seen annually. Autopsies to establish diagnoses in patients with dementia, patients with mild MCI, and cognitively normal elderly control subjects will also be conducted.

Detailed Description
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All participants are seen annually. In addition to a detailed neurological examination, participants will receive a standardized battery of neuropsychological tests and will undergo genetic testing. The investigators will provide standardized periodic longitudinal assessment of the research participants. Autopsies to establish neurohistopathological diagnoses in clinically well-characterized patients with dementia, patients with mild MCI, and cognitively normal elderly control subjects will also be conducted.

Official Title
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Arizona Alzheimer's Disease Core Center

Conditions
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Alzheimer's Disease, Mild Cognitive Impairment, Age-Related Memory Disorders

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: For patients with MCI, or dementia, the presence of cognitive deficits including memory, language, and executive function. Exclusion Criteria: Presence of non-neurological medical conditions interfering with cognition.

Ages Eligible for Study
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Minimum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Alzheimer's Disease<br> | |
| Mild Cognitive Impairment<br> | |
| Other forms of Dementia, not AD<br> | |
| Normal Elderly Individuals<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Neuropsychological Test Scores | Cognitive function will be evaluated on a yearly basis using a battery of neuropsychological tests, which will then be scored and normed according to established guidelines. | Up to 20 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Neurological Exam | A thorough neurological exam will be performed once per year to evaluate neurological function. | Up to 20 Years | 
| Brain Tissue | A brain autopsy will be performed upon the participant's death to establish histological diagnosis. | From date of entry until date of death assessed up to 20 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Alzheimer's, Dementia, Mild Cognitive Impairment