Glucose Metabolism and Sleep in People With Family History of Type 2 Diabetes.

Study Overview
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Brief Summary
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The use of sugar and starch-like foods for energy (carbohydrate metabolism) changes when people sleep. However, it is still not known if differences in the amount of nighttime sleep have an effect on the carbohydrate metabolism of people who have a relative with type 2 diabetes (parent, sibling, or grandparent). This study is being done to test the hypothesis that individual differences in habitual sleep duration may be related to differences in the carbohydrate metabolism of people who have a history of type 2 diabetes in their family.

Detailed Description
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On two consecutive inpatient days, the participants in this study will undergo two different tests. The first test will determine how much insulin can their body produce in response to an intravenous glucose infusion over a period of several hours. The second test will determine how effective is the action of the sugar-processing hormone, insulin, in their body when it is infused intravenously together with glucose over a period of several hours.

Official Title
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Sleep, Energy Metabolism and Diabetes Risk.

Conditions
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Sleep, Insulin Resistance, Type 2 Diabetes

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: regular sleep habits BMI 20 to 27 kg/m2 at least one parent, sibling or grandparent with type 2 diabetes no regular exercise habits Exclusion Criteria: active smoker night or shift work have highly variable sleep habits have a hormonal disorder have a sleep disorder have an active medical problem women only: use of birth control pills women only: irregular menstrual periods or pregnancy use of medications/compounds that can disrupt sleep

Ages Eligible for Study
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Minimum Age: 21 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Reduced sleep<br>Habitual sleep duration of less than 6 hours per night on most days of the week and total sleep of less than 43 hours per week. | |
| Reference sleep<br>Habitual sleep duration between 7 and 8.5 hours per night on most days of the week and total sleep of at least 53 hours per week. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Total body insulin sensitivity |  | at the end of a 4-hour hyperinsulinemic clamp | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| First and second phase insulin secretion |  | during a 3-hour hyperglycemic clamp | 
| Endogenous glucose production |  | before and during a 4-hour hyperinsulinemic clamp | 
| Glycerol turnover and free fatty acid concentration |  | before and during a 4-hour hyperinsulinemic clamp | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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short sleep duration, glucose clamp technique, insulin secretion, insulin action, lipid turnover, free fatty acids