Sequelae of Developmental Dysplasia of the Hip

Study Overview
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Brief Summary
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The aim of this study is to assess long term effects of developmental dysplasia of the hip (DDH) to overall health and quality of life later in life. We compare hip radiographs, hip symptoms, clinical examination, head asymmetry, dental examination and intraoral scans of 170 children and young adults treated for DDH in their childhood with age and sex matched controls.

Detailed Description
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Developmental dysplasia of the hip (DDH) is the most common musculoskeletal disorder in infancy. However there are few reports of long term effects of successfully treated DDH. Incidence of DDH in neonatal period is approximately 1-10/1000 depending on screening protocols used, the age of the infant during screening and which ultrasonographic findings are considered normal and which DDH. The prevalence of hip dysplasia in adult population is grossly 4 % when using Wibergs Centre-Edge (CE) ≤ 20° as definition of dysplasia. It is still unclear, what is the relation between adult acetabular dysplasia and developmental dysplasia in children. Hip dysplasia overall is a major contributing factor in hip osteoarthrosis and total hip replacement in young adults. The aim of this study is to assess long term effects of developmental dysplasia of the hip to overall health and quality of life later in life. We compare hip radiographs, hip symptoms, clinical examination, head asymmetry, dental examination and intraoral scans of 170 children and young adults treated for DDH in their early childhood with age and sex matched controls.

Official Title
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Structural and Functional Sequelae of Developmental Dysplasia of the Hip

Conditions
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Developmental Dysplasia of the Hip, Hip Dysplasia

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria for person treated for DDH: DDH has been diagnosed by clinical examination, ultrasound examination or by radiological examination and treatment begun before age of 1,5 years. Treated in Oulu University Hospital Exclusion Criteria: neurological or developmental condition which can influence hip development such as cerebral palsy or spina bifida other significant congenital anomalies of musculoskeletal system such as club feet

Ages Eligible for Study
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Minimum Age: 10 Years
Maximum Age: 30 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Treated for DDH in childhood<br>Subjects have had DDH in childhood. DDH has been diagnosed before age of 1,5 years and treated for. | |
| Control<br>Age an sex matched controls of DDH patients | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Wibergs Centre-Edge Angle | angle degree | 10 - 30 years after DDH has been treated | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The Copenhagen Hip and Groin Outcome Score (HAGOS) | score in numbers | 10 - 30 years after DDH has been treated | 
| Oral Heath Impact Profile | Oral Heath Impact Profile (OHIP-14) -questionaire to assess Oral Health-related Quality of Life | 10 - 30 years after DDH has been treated | 
| Occlusal asymmetries | Determined by dental examination and intraoral scan | 10 - 30 years after DDH has been treated | 
| Presence of facial asymmetry | Determined by 3D -photogrammetric images | 10 - 30 years after DDH has been treated | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Developmental dysplasia of the hip, Hip dysplasia, Occlusal defect