The Checklist for Early Recognition and Treatment of Acute Illness (CERTAIN)

Study Overview
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Brief Summary
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The purpose of the study is to test whether the health care provider access and training in CERTAIN (Checklist for Early Recognition and Treatment of Acute Illness), would facilitate timely and error free best-practice delivery and minimize preventable death and costly complications in critically ill patients.

Official Title
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The Checklist for Early Recognition and Treatment of Acute Illness (CERTAIN)

Conditions
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Critical Illness, Sepsis, Respiratory Failure, Shock, Coma, Bleeding, Trauma

Intervention / Treatment
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* Other: Checklist for Early Recognition and Treatment of Acute Illness (CERTAIN)


Participation Criteria
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Eligibility Criteria
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Inclusion: All adult (≥ 18 years) patients admitted for the first time to the participating ICUs will be included. Exclusion: Not critically Ill, admitted for low risk monitoring, planned ICU admissions for routine postoperative surveillance for less than 24 hours after uncomplicated surgery, readmission and transferred from outside ICU.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Baseline arm<br>baseline data (50 patients or 3 months per center) | Other: Checklist for Early Recognition and Treatment of Acute Illness (CERTAIN)<br>* This study is about training and implementation of best critical care practices in the international ICUs with variable resources facilitated by access to a specifically designed electronic checklist<br>* Other names: Checklist;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Adherence to best critical care practices | Adherence to best practice in initial evaluation and treatment of critically ill medical and surgical patients Appropriate shock resuscitation Appropriate sepsis treatment Appropriate mechanical ventilation Appropriate peptic ulcer, deep vein thrombosis and infectious disease prophylaxis | Participants will be followed for the duration of ICU stay, an expected average of 2 weeks | 
| ICU and hospital lengths of stay | Patient will be followed till they get discharged from hospital for whatever length they stay. | Participants will be followed for the duration of hospital stay, an expected average of 8 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality for 4 weeks | Patient will be followed for 4 weeks and hospital discharge(up to total 10 weeks post discharge) | Participants will be followed for the duration of 4 weeks and hospital discharge (up to 10 weeks post discharge) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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CERTAIN, Checklist, ICU, Outcome, Adults