HIT in Insulin-resistant and Insulin-sensitive Obese Adolescents

Study Overview
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Brief Summary
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Evaluate the effects of HIT on the cardiorespiratory performance and substrate oxidation of insulin-resistant and insulin-sensitive obese adolescents.

Detailed Description
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Objective: To evaluate the effect of high-intensity interval training (HIT) on the cardiorespiratory performance and substrate oxidation pattern in insulin-resistant and insulin-sensitive obese adolescents.

Official Title
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Effects of High-intensity Interval Training on Cardiorespiratory Performance and Substrate Oxidation in Insulin-resistant and Insulin-sensitive Obese Adolescents: A Before-and-after Clinical Study

Conditions
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Obesity, Insulin-resistant, Adolescents

Intervention / Treatment
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* Other: Group Insulin-Resistant
* Other: Group Insulin-Sensitive


Participation Criteria
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Eligibility Criteria
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Criteria Inclusion Criteria: aged 12-16 years with a body mass index z-score (zBMI) ≥ + 2SD puberty stage > 3 the boys and girls had to present a minimum physical fitness, according to the International Physical Activity Questionnaire (IPAQ), according to the activity performed during the last week and confirmed this using the peak cardiopulmonary test (VO2). Exclusion Criteria: individuals undergoing drug treatment for weight control; indiviudals who had cardiac, orthopedic, respiratory or renal problems, diabetes, uncontrolled hypertension, genetic syndrome or hormonal abnormalities.

Ages Eligible for Study
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Minimum Age: 12 Years
Maximum Age: 16 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Group Insulin-resistant<br>Insulin-resistant obese adolescents | Other: Group Insulin-Resistant<br>* High intensity interval training: 3 to 6 sets of 60-second sprints at 100% of the peak velocity interspersed by a 3-min active recovery period.<br>* Other names: Insulin-resistant obese adolescents;Other: Group Insulin-Sensitive<br>* High intensity interval training: 3 to 6 sets of 60-second sprints at 100% of the peak velocity interspersed by a 3-min active recovery period.<br>* Other names: Insulin-sensitive obese adolescents;|
| Experimental: Group Insulin-sensitive<br>Insulin-sensitive obese adolescents | Other: Group Insulin-Resistant<br>* High intensity interval training: 3 to 6 sets of 60-second sprints at 100% of the peak velocity interspersed by a 3-min active recovery period.<br>* Other names: Insulin-resistant obese adolescents;Other: Group Insulin-Sensitive<br>* High intensity interval training: 3 to 6 sets of 60-second sprints at 100% of the peak velocity interspersed by a 3-min active recovery period.<br>* Other names: Insulin-sensitive obese adolescents;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| rate of Peak oxygen consumption (VOpeak) | The cardiopulmonary test protocol for determination the VOpeak (ml/kg/min) included running on a treadmill (Model ATL, Inbrasport Ltda; Brazil) at a speed of 4 km/h with 1 km/h increments every minute until the participant showed exhaustion. We evaluated ventilatory parameters on a gas analyzer (model VO2000; Inbrasport Ltda; Brazil). | 4 weeks | 
| rate of Intensity at first ventilatory anaerobic threshold (VAT1) | The cardiopulmonary test protocol included running on a treadmill (Model ATL, Inbrasport Ltda; Brazil) at a speed of 4 km/h with 1 km/h increments every minute until the participant showed exhaustion. We evaluated ventilatory parameters on a gas analyzer (model VO2000; Inbrasport Ltda; Brazil).We determined VAT1 (ml/kg/min) using the V-slope method of Beaver et al. | 4 weeks | 
| rate of Peak Heart rate | The cardiopulmonary test protocol included treadmill running (Model ATL, Inbrasport Ltda; Brazil). speed of 4 km / h with increments of 1 km / h every minute until the participant shows exhaustion. | 4 weeks | 
| rate of carbohydrate oxidation | The substrate oxidation pattern protocol included treadmill running (Model ATL, Inbrasport Ltda; Brazil),during continuous exercise of submaximal intensity (45 minutes of treadmill running at the intensity of the first ventilatory anaerobic threshold). | 4 weeks | 
| rate of lipid oxidation | The substrate oxidation pattern protocol included treadmill running (Model ATL, Inbrasport Ltda; Brazil),during continuous exercise of submaximal intensity (45 minutes of treadmill running at the intensity of the first ventilatory anaerobic threshold). | 4 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Adolescents, Obesity, Insulin-resistant, High-intensity interval training