Predictor of Residual Neuromuscular Blockade in Recovery Room After General Anesthesia

Study Overview
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Brief Summary
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Background When general anesthesia was performed, neuromuscular blocking agents (NMBAs) are frequently used for facilitate tracheal intubation and keep patient still and relax during surgery. Unfortunately, residual neuromuscular blockade are important complication. There are many factors that affect neuromuscular blockade and may prolong effect of NMBAs which we already know about that such as body temperature, drugs, some kind of diseases. However there are no recent studies that mention about other factors. The purpose of this study is to find out other factors that affect NMBAs effect to improve patient safety. Methods The study is a prospective, non-randomized, blinded, observational study. 222 patients will be included in this study and will be performed general anesthesia. Anesthetic technique and agent which are used depend on regular staff. Information of patient will be collected are age, sex, weight, height, ASA classification, anesthetic technique, anesthetic and surgical time, amount of inhalation agent, amount of NMBAs, amount of opioids and reversal agents. After anesthesia finish, patient will be brought to recovery room and Train Of Four watch® will be placed and record Train Of Four ratio by this research staff. Train Of Four ratio < 0.9 will be defined as there is residual neuromuscular blockade in this patient. All patients will be divided into 2 groups: residual blockade group(patient who have train of four <0.9 after surgery) and no residual blockade group(patient who have train of four >0.9). All factor of each group will be compared between. Statistical will be analyzed to find significant factor which affect neuromuscular blockade.

Detailed Description
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study about residual neuromuscular blockade

Official Title
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Predictor of Residual Neuromuscular Blockade in Recovery Room After General Anesthesia

Conditions
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Residual Neuromuscular Blockade

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: - age ≥ 18 years American society of anesthesiologist class I-III patient who are schedule for intraabdominal surgery, orthopedic surgery and gynecologic surgery under general anesthesia and use neuromuscular blocking agents (NMBAs) Exclusion Criteria: - patients who have myasthenia gravis, myotonia, muscular dystrophy, upper motor neuron lesion patients who have drug which influence neuromuscular action such as oral muscle relaxant, anticonvulsants, magnesium sulfate Body temperature >37.8 or < 36 degree Celsius before operation

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| general anesthesia<br>Patient having general anesthesia | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| residual neuromuscular blockade after surgery | residual neuromuscular blockade after surgery measure by train of four of nervestimulator | 1 hour | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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residual neuromuscular blockade