Epidemiology of In-hospital Acute Kidney Injury

Study Overview
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Brief Summary
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Retrospective observational study to investigate acute kidney injury (AKI) epidemiology and outcomes in patients hospitalized in University Hospital San Martino, Genova, Italy.

Detailed Description
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A retrospective observational study was designed to investigate acute kidney injury (AKI) epidemiology and outcome in patients hospitalized in University Hospital San Martino, Genova, Italy. All data will be extracted from the hospital electronic database. The investigators will evaluate demographic, clinical and laboratory data, including age, sex, serum creatinine (sCr), sodium and electrolytes, intensive care unit (ICU) admission, length of hospital stay, death, comorbidities and primary diagnosis codes at the hospital discharge (using International Classification of Diseases-ICD-9- codes). The investigators will include also patients affected by Coronavirus disease 19 (COVID-19). The primary endpoint will be to describe AKI epidemiology, secondary endpoints will be to evaluate AKI-related risk factors and clinical outcomes, such as length of stay and mortality. Moreover, the investigators will describe the differences in the outcome and treatments of AKI patients in the medical wards and ICU.

Official Title
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Analysis of In-hospital Acute Kidney Injury Epidemiology, Treatment and Outcomes

Conditions
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Acute Kidney Injury, Dialysis; Complications, Chronic Kidney Diseases

Intervention / Treatment
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* Other: Data collection


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients admitted to University Hospital San Martino, Italy We'll include also patients affected by Coronavirus disease 19 (COVID-19). Exclusion Criteria: Hemodialysis patients

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients admitted to University Hospital San Martino, Genova, Italy<br>Adult patients admitted to University Hospital San Martino, Genova, Italy | Other: Data collection<br>* Collection and analysis of data related to AKI epidemiology, treatment and outcomes<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Acute Kidney Injury incidence | Rate of in-hospital Acute Kidney Injury incidence | Collection of retrospective data from 2016 | 
| Acute Kidney Injury severity | Staging of in-hospital Acute Kidney Injury according to the KDIGO guidelines | Collection of retrospective data from 2016 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality in Acute Kidney Injury patients | Rate of in-hospital mortality among patients with Acute Kidney Injury | Collection of retrospective data from 2016 | 
| Creatinine clearance after discharge | Data on kidney function after the discharge in Acute Kidney Injury patients | Collection of retrospective data from 2016 |