Heart Rate Variability and Its Association With Symptom of Orthostatic Hypotension in Spinal Cord Injury

Study Overview
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Brief Summary
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In this study, the SCI patients were sub-grouped on the basis of symptoms into symptomatic and asymptomatic groups and measured HRV during resting and tilt up tests to compare their cardiovascular autonomic functions.

Detailed Description
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In study protocol and the subjects were asked to lie down quietly for 5 minutes, closing their eyes and avoiding talking, moving hand, legs and body, and coughing during the test. R-R interval and blood pressure were measured beat-to-beat using Finometer® PRO (Finapres Medical Systems, Amsterdam, Netherlands) for 6 minutes each in two positions, supine and 60-degree angle on the tilt table.

Official Title
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Heart Rate Variability and Its Association With Symptom of Orthostatic Hypotension in Spinal Cord Injury

Conditions
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Spinal Cord Injuries, Orthostatic Hypotension, Heart Rate Variability

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: spinal cord injury with or without OH aged 19 or older ASIA Impairment Scale (AIS) A to D neurological level of injury above T6. Exclusion Criteria: Those with heart and respiratory diseases, neurological diseases other than SCI - medically unstable states Those who are taking medications affecting BP that cannot be stopped

Ages Eligible for Study
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Minimum Age: 19 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| non-OH group<br>without orthostaric hypotension in spinal cord injuries | |
| symptomatic OH group<br>Symptomatic individuals in a patient population diagnosed with orthostatic hypotension (Symptom : dizziness, visual disturbance, nausea and headache) | |
| asymptomatic OH group<br>Asymptomatic individuals in a patient population diagnosed with orthostatic hypotension | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Differences of heart rate variability between groups (OH vs non-OH, asymptomatic-OH vs symptomatic-OH group) | mean HR (heart rate), mean RR(RR interval), RMSSD (mean square of the successive R-R interval differences), SDNN (standard deviation of normal-to-normal interval), LF (low frequency) domain, HF(High frequency) domain | at the test time (15minutes) | 
| Logistic regression analysis of heart rate variability variables according to OH and presence of symptom | the investigators conducted logistic regression analysis to evaluate the significance and impact of HRV variables associated with orthostatic hypotension and its symptoms in spinal cord injury patients. | at the test time (15minutes) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Spinal Cord Injuries, Orthostatic Hypotension, Heart rate variability, Autonomic nervous system