Anesthesia Related Neurocognitive Deficits in Children

Study Overview
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Brief Summary
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The infantile brain has to pass essential, mayor steps in the first 36 months of life. During that period of development it is particularly vulnerable to toxic, exogenic influences. This study wants to review the long-term effects of children who were exposed to anesthesia in the first three years of their life. Therefore the investigators will examine children at age of 4-10 that were exposed to anesthesia and compare their neurocognitive capacity to children who did not have any exposure to anesthesia. The investigators plan on measuring the intelligence quotient using standardized tests which will be performed by a trained psychologist. In addition there will be a questionnaire concerning behavioral characteristics and educational development which is filled by the parents. The exposed children will be recruited from our preexisting database, the control group will be recruited from practitioners and the pediatric walk-in-clinic.

Official Title
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Neurocognitive Development in Children Who Received General Anesthesia Before the Age of 3 Years: A Historic-prospective, Controlled, Single Center Cross-section Trial

Conditions
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Anesthesia

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: General anesthesia before the age of 36 months Exclusion Criteria: neurosurgical interventions cardiac surgery preexisting hereditary or acquired cognitive deficits no informed consent

Ages Eligible for Study
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Minimum Age: 4 Years
Maximum Age: 10 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Exposed<br>Children age 4-10 who required general anesthesia before the age of 36 months in the context of surgical and diagnostic procedures or sedation during intensive care, excluding neurosurgical interventions or cardiac surgery as well as preexisting hereditary or acquired neurocognitive deficits | |
| Control<br>Children age 4-10 who did not require any anesthesia before the age of 36 months. Excluding preexisting hereditary or acquired neurocognitive deficits. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cognitive Capacity for children between 7 and 10 years of age | Standardized tests for intelligence quotient (IQ): Kaufman Assessment Battery for Children - Second Edition (KABC-II) | Test is done 1 to 10 years after anesthesia and is lasting 3 hours | 
| Cognitive Capacity for children between 4 and 7 years of age | Standardized tests for intelligence quotient (IQ): Wechsler Preschool and Primary Scale of Intelligence (WPPSI-III) | Test is done 1 to 10 years after anesthesia and is lasting 3 hours | 
| Cognitive Capacity for children between 2 and 4 years of age | Standardized tests for intelligence quotient (IQ): Wechsler Intelligence Scale for Children (WISC-IV) | Test is done 1 to 10 years after anesthesia and is lasting 3 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Educational status | Questionnaire, filled by parents 1-10 years after anesthesia exposure | 1 to 10 years after anesthesia, lasting 30 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Anesthesia, Children, General Anesthesia, Neurocognitive Outcome