Determination of the Tissue Transit Time (TTT)

Study Overview
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Brief Summary
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Determination of Tissue Transit Time (TTT) as a parameter with high prognostic value to predict the functional course of the differential renal function and the development of the differential renal function after pyeloplasty

Detailed Description
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The ureteropelvic junction obstruction occurs in around 13% of children with antenatally diagnosed hydronephrosis. It remains a controversial topic what prognostic factors may be predictive for deterioration of the differential renal function. The tissue transit time (TTT) in the 99mTc- MAG3 diuretic renogram seems to be a predictive factor for the deterioration of the differential renal function in these patients. We therefore analyze the tissue transit time in the 99mTc- MAG3 diuretic renogram in a prospective multicenter observational study to determine it as a prognostic and diagnostic factor. Aim of the study is to differentiate which children could be treated conservatively and which will benefit from operative pyeloplasty

Official Title
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Determination of the Tissue Transit Time (TTT) in the MAG3-Tc99 Diuretic Renogram for Risk Stratification of Infants With Ureteropelvic Junction Obstruction - a Multicentric Prospective Observational Study

Conditions
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Renal Insufficiency, Acute

Intervention / Treatment
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* Diagnostic Test: Tissue Transit Time


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: unilateral, isolated hydronephrosis >= grade III (SFU) age <= 3 months Exclusion Criteria: associated malformation of the urogenital tract global kidney insufficiency proven by creatinine examination prematurity no informed consent

Ages Eligible for Study
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Maximum Age: 3 Months

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: Tissue Transit Time|Determination of Tissue Transit Time as a prognostic and diagnostic factor|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sensitivity and Specificity | Estimation of Sensitivity and Specificity of a delayed tissue transit time as a diagnostic factor concerning worsening of the differential renal function in patients with congenital ureteropelvic junction obstruction | 3 to 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Examination of ultrasound findings | Relationship between ultrasound findings and the development of the differential renal function | 3 to 6 months | 
| Examination of renal drainage | Relationship between initial quality of renal drainage and the development of the differential renal function | 3 to 6 months | 
| Examination of initial differential renal function | Relationship between initial differential renal function and the development of the differential renal function | 3 to 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Tissue Transit Time