Pulse Wave Velocity and Hemodynamic Response During Anesthesia Induction in Hypertensive Patients

Study Overview
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Brief Summary
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Hypertension is a disease with increasing and serious complications all over the world. In particular, the incidence of hypertension increases with advancing age. Secondary problems that can be caused by hypertension include peripheral vascular diseases, arteriosclerosis, increased risk of heart attack and stroke. It is a measurement of pulse wave velocity (PWV), a non-invasive indicator of arterial stiffness. It is known that sudden hemodynamic changes that occur during the induction of anesthesia cause undesirable intraoperative and postoperative complications. It is known that arterial stiffness, which is more common in elderly patients, causes orthostatic hypotension in particular. For this reason, more hemodynamic instability may be seen in the general anesthesia procedure in elderly patients with increased arterial stiffness. In our study, we aimed to investigate whether the hemodynamic changes observed during anesthesia induction in hypertensive elderly patients, whom we think have a high pulse wave velocity, are different from normotensive patients.

Official Title
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Comparison of the Relationship Between Preoperatively Measured Pulse Wave Velocity and Hemodynamic Changes During Anesthesia Induction in Hypertensive and Normotensive Patients.

Conditions
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Arterial Stiffness

Intervention / Treatment
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* Procedure: Mobil-O-Graph PWA


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: According to the American Society of Anesthesiologists (ASA), physical condition I-II, Elective otolaryngology surgery with endotracheal intubation planned Patients aged 50 and over Exclusion Criteria: Hypersensitivity to drugs Difficult intubation history Diabetes mellitus receiving insulin therapy Chronic renal failure or end-stage renal disease Heart failure (left ventricular ejection fraction ≤30%) Valve disease (moderate to severe) Atrial fibrillation

Ages Eligible for Study
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Minimum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group H<br>Hypertension group (Group H): Patients with a previous diagnosis of hypertension Patients receiving antihypertensive therapy Systolic blood pressure (SBP) ≥140mmHg and/or diastolic blood pressure (DBP) ≥90mmHg | Procedure: Mobil-O-Graph PWA<br>* After resting in a quiet room preoperatively, blood pressure was measured on the right arm using an oscillometric method.<br>|
| Group N<br>Normotensive group (Group N): Other non-hypertensive patients | Procedure: Mobil-O-Graph PWA<br>* After resting in a quiet room preoperatively, blood pressure was measured on the right arm using an oscillometric method.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Difference between hemodynamic values | The difference between the hemodynamic values measured preoperatively and during anesthesia induction was calculated. In addition, ≥20% decrease in preoperative hemodynamic value and/or systolic blood pressure ≤90 mmHg hypotension, ≥20% increased hypertension | Basal measurement before induction of anesthesia, then at 1-minute intervals until after endotracheal intubation |