Effect of Non Surgical Treatment of Periodontitis on Diabetes Control

Study Overview
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Brief Summary
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The aim of this study is to investigate the effects of non-surgical periodontal treatment on the metabolic control of type2 diabetes patients. Patients with type two diabetes mellitus patients and confirmed chronic periodontitis will be selected and randomly assign to two groups. The treatment group will receive immediate full-mouth scaling and root planing whereas the control group will be scheduled to receive periodontal treatment at the following 3-month visit. Plaque index, bleeding index, probing pocket depth, recessions and cervical attachment loss will be recorded at baseline, at six weeks and at three months. Glycated haemoglobin (HbA1c) and C-reactive protein (CRP) will be analysed at baseline and three months following enrolment.

Detailed Description
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The aim of this study is to investigate the effects of non-surgical periodontal treatment on the metabolic control of type2 diabetes patients. Patients with type two diabetes mellitus patients and confirmed chronic periodontitis will be selected and randomly assign to two groups. The treatment group will receive immediate full-mouth scaling and root planing whereas the control group will be scheduled to receive periodontal treatment at the following 3-month visit. Plaque index, bleeding index, probing pocket depth, recessions and cervical attachment loss will be recorded at baseline, at six weeks and at three months. Glycated haemoglobin (HbA1c) and C-reactive protein (CRP) will be analysed at baseline and three months following enrolment.

Official Title
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Effect of Non Surgical Treatment of Periodontitis on Glycaemic Control in a Type 2 Diabetic Populations of Cameroon

Conditions
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Periodontitis, Diabetes

Intervention / Treatment
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* Procedure: non-surgical periodontal treatment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Type 2 diabetes for at least one year periodontitis HbA1c > 7% Exclusion Criteria: Periodontal treatment in the last 6 months antibiotics in the last 3 months tobacco smoking pregnancy

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: treatment<br>immediate non-surgical periodontal treatment | Procedure: non-surgical periodontal treatment<br>* full-mouth scaling and root planing<br>|
| Other: control<br>non-surgical periodontal treatment scheduled for the following 3-monthly visit | Procedure: non-surgical periodontal treatment<br>* full-mouth scaling and root planing<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Metabolic | Change in HbA1c | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Inflammation | change in CRP level between baseline and 3-month post intervention | 3 months | 
| Periodontal 1 | Change in plaque index between baseline and 3-month post intervention | 3 months | 
| Periodontal 2 | Change in bleeding index between baseline and 3-month post intervention | 3 months | 
| Periodontal 3 | Change in pocket depth between baseline and 3-month post intervention | 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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periodontitis, diabetes, HbA1c, inflammation