Brain Derived Neurotropic Factor Response to Aerobic Exercise Intensity in Depressive Patients.

Study Overview
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Brief Summary
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Acute aerobic exercise improves affective stats in patients with mental illnesses. Brain derived neurotropic factor (BDNF) may be a biological mechanism that contributes to the affective benefits. The magnitude of the increase of serum BDNF might be exercise intensity dependent, but no study has compared low high-aerobic-intensity training at 90-95 % of the maximal heart rate (HRmax) with long-slow-distance training at 70 % of the HRmax in patients with depression. The aim of this study is to compare changes in serum BDNF levels after high-aerobic-intensity training and long-slow-distance training in a intra-individual design in patients suffering from depression. The results will give indications of a possible difference in BDNF response between aerobic intensities and may be uses as pilot data for calculating sample size.

Official Title
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Effects of Aerobic Exercise Intensity on Affective States and Brain Derived Neurotropic Factor in Patients With Depression

Conditions
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Depressive Disorder, Depressive Disorder, Major

Intervention / Treatment
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* Behavioral: High aerobic intensity training (HIT)
* Behavioral: Long slow distance training (LSD)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Moderate or severe depression (ICD10: F32-F33) Exclusion Criteria: Bipolar disorder.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Exercise<br>Acute High aerobic intensity training (HIT) and long slow distance training (LSD) | Behavioral: High aerobic intensity training (HIT)<br>* One training session, high aerobic intensity training (HIT) at 90-95 % of the maximal heart rate (HRmax)<br>Behavioral: Long slow distance training (LSD)<br>* One training session, long slow distance training (LSD) at 70 % of the HRmax<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in serum brain derived neurotropic factor (BDNF) | To measure serum BDNF levels, blood samples will be taken before and after each workout session. | 15 minutes before exercise to 5> minutes after exercise. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in affective symptoms | The positive and negative affect schedule (PANAS) . | 15 minutes before exercise to 15> minutes after exercise. | 
| Change in state of anxiety. | A short form of state trait anxiety inventory for adults (STAI) is used to detect their state of anxiety. | 15 minutes before exercise and 15> minutes after exercise. | 
| Change in subjective exercise experience | The Subjective exercise experience scale (SEES). | 15 minutes before exercise to 15> minutes after exercise. | 
| Maximal oxygen uptake |  | Baseline | 
| Maximal Heart rate |  | Baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Exercise therapy