Presbyopia Compensation: Looking for Electrophysiological Predictors

Study Overview
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Brief Summary
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The main purpose of this study was to identify electrophysiological predictive markers of post-correction visual comfort for presbyopic patients.

Detailed Description
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For each participant, presbyopia was compensated with contact lenses by monovision during three weeks and multifocality (three weeks again). A break of two weeks without any presbyopia compensation came in between the two phases of the test that were randomized. All subjects were tested three times: before any compensation, after three weeks with monovsion and after three weeks with multifocality. Each testing session was strictly the same including visual examinations and VEPs (visual evoked potentials).

Official Title
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Presbyopia Compensation: Looking for Electrophysiological Predictors

Conditions
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Presbyopia

Intervention / Treatment
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* Device: contact lenses


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: normal acuity Exclusion Criteria: stereoacuity disorder neurological disorders

Ages Eligible for Study
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Minimum Age: 45 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: contact lenses|Presbyopia was compensated with contact lenses by monovision and multifocality.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Visual acuity at baseline | near and distance visual acuity (Monoyer and Parinaud scales) | baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| electrophysiological recordings at baseline | monocular and binocular pattern Visual Evoked Potentials in response to a checkerboard pattern N75 and P100 components : amplitude, latency and topography | baseline | 
| electrophysiological recordings change with monovision | monocular and binocular pattern Visual Evoked Potentials in response to a checkerboard pattern N75 and P100 components : amplitude, latency and topography | after 3 weeks with monovision contact lenses | 
| electrophysiological recordings with multifocality | monocular and binocular pattern Visual Evoked Potentials in response to a checkerboard pattern N75 and P100 components : amplitude, latency and topography | after 3 weeks with multifocality contact lenses | 
| quantitative measurement of stereopsis at baseline | TNO plates | baseline | 
| quantitative measurement of stereopsis with monovision | TNO plates | after 3 weeks with monovision contact lenses | 
| quantitative measurement of stereopsis with multifocality | TNO plates | after 3 weeks with multifocality contact lenses | 
| Visual acuity change with monovision | near and distance visual acuity (Monoyer and Parinaud scales) | after 3 weeks with monovision contact lenses | 
| Visual acuity change with multifocality | near and distance visual acuity (Monoyer and Parinaud scales) | after 3 weeks with multifocality contact lenses | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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multifocality, monovision