Review of Trend in Incidence and Characteristics of Hospital-acquired Acute Kidney Injury in Hospital Selayang

Study Overview
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Brief Summary
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This retrospective cohort study aims to investigate the incidence, risk factors and outcomes of Hospital-acquired Acute Kidney Injury in Hospital Selayang, a tertiary hospital at Malaysia, over 15 years.

Detailed Description
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This is a retrospective cohort study involving 5-yearly trend from 2002 to 2017 for analysis. Laboratory serum creatinine (SCr) results of all patients admitted during study period will be retrieved from the hospital Laboratory Information System. A preliminary screening list will be generated by using STATA program from the SCr results. The nephrologist will then determine HA-AKI and CA-AKI as per inclusion and exclusion criteria. Data collectors will collect all relevant data from these patients.

Official Title
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Review of Trend in Incidence and Characteristics of Hospital-acquired Acute Kidney Injury in Hospital Selayang

Conditions
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Acute Kidney Injury, Acute Renal Failure, Kidney Failure, Acute, Hospital Acquired Condition

Intervention / Treatment
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* Other: No AKI
* Other: CA-AKI
* Other: HA-AKI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adult admissions to Hospital Selayang from 1st July 2001 to 30th June 2002 1st July 2006 to 30th June 2007 1st July 2011 to 30th June 2012 1st July 2016 to 30th June 2017 Exclusion Criteria: End Stage Renal Failure and on Renal Replacement Therapy (Hemodialysis, peritoneal dialysis or Renal Transplant)

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No AKI<br>Adult admissions without Acute Kidney Injury during their stay | Other: No AKI<br>* Subjects will be allocated into this group if they did not acquire Acute Kidney Injury during admission.<br>|
| CA-AKI<br>Adult admissions with Acute Kidney Injury diagnosed within 48 hours during their stay (Community-acquired Acute Kidney Injury) | Other: CA-AKI<br>* CA-AKI is defined by any patient who developed AKI (as per definition below) within 48 hours of hospital admission. Definition of AKI: i. An increase in serum creatinine of 0.3 mg/dl (26.5 μmol/l) within 48 hours OR ii. An increase in serum creatinine to more or equal to 1.5 times baseline, which is known or presumed to have occurred within the prior 7 days Definition for baseline creatinine: i. The baseline creatinine level is defined as the creatinine level at or within 7 days before the hospital admission, OR ii. at the hospital admission OR iii. the lowest creatinine (excluding the post dialysis creatinine if dialysis is initiated) during the index hospitalisation for those whose baseline creatinine were unknown.<br>|
| HA-AKI<br>Adult admissions with Acute Kidney Injury diagnosed after 48 hours during their stay (Hospital-acquired Acute Kidney Injury) | Other: HA-AKI<br>* HA-AKI is defined by any patient who developed AKI (as per definition below) after 48 hours of hospital admission. Definition of AKI: i. An increase in serum creatinine of 0.3 mg/dl (26.5 μmol/l) within 48 hours OR ii. An increase in serum creatinine to more or equal to 1.5 times baseline, which is known or presumed to have occurred within the prior 7 days Definition for baseline creatinine: i. The baseline creatinine level is defined as the creatinine level at or within 7 days before the hospital admission, OR ii. at the hospital admission OR iii. the lowest creatinine (excluding the post dialysis creatinine if dialysis is initiated) during the index hospitalisation for those whose baseline creatinine were unknown.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of Hospital-acquired Acute Kidney Injury | Incidence of Hospital-acquired Acute Kidney Injury among the adult admissions | During admissions to study site (Year 2001-2002, Year 2006-2007, Year 2011-2012, Year 2016-2017) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Renal Recovery from Hospital-acquired Acute Kidney Injury | Renal Recovery among adult admissions for Hospital-acquired Acute Kidney Injury | 90 days after diagnosis of Acute Kidney Injury | 
| In-hospital Mortality from Hospital-acquired Acute Kidney Injury | Mortality rate among adult admissions for Hospital-acquired Acute Kidney Injury | During admissions to study site with Hospital-acquired Acute Kidney Injury, through study completion (an average of 1 year) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Acute Kidney Injury, Hospital-acquired Acute Kidney Injury, Community-acquired Acute Kidney Injury, Acute Renal Failure