Efficacy of Social Cognition Training in Schizophrenia

Study Overview
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Brief Summary
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The term social cognition refers to how social information is processed. Individuals with schizophrenia and schizoaffective disorder have been shown to have significant deficits in social cognition. Moreover, it has been speculated that these deficits may in turn have a negative impact on their overall functioning. Behavioral interventions targeting social cognition are just beginning to emerge, and there is a need to evaluate their efficacy. Objectives: This is a small trial evaluating the efficacy of social cognition interaction training (SCIT) an experimental behavioral treatment for improving social cognition in schizophrenia. Research Design and Methodology: Approximately 48 participants with schizophrenia-spectrum disorders will be randomized into one of two conditions: 1) a 20 to 24 session manualized social cognition interaction training group (SCIT), or 2) wait-list control. Pre-and post-group therapy assessments of symptoms, social cognition, basic cognition, and community function will be conducted. Data obtained from this study will allow us to determine the efficacy of SCIT training in improving symptom, cognitive, and functional measures.

Official Title
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Efficacy of Social Cognition Training in Schizophrenia

Conditions
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Schizophrenia

Intervention / Treatment
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* Behavioral: Social Cognition Interaction Training
* Behavioral: WLC


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: diagnosis of schizophrenia or schizoaffective disorder Age between 18 and 65 minimum of 30 days since discharge from last hospitalization minimum of 30 days since last change in psychiatric medications no housing changes in the past 30 days Exclusion Criteria: current diagnosis of alcohol or substance abuse/dependence history of brain trauma or neurological disease mental retardation or developmental disability auditory or visual impairment that would interfere with study procedures

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1 Social Cognition Interaction Training<br>Will receive 20-26 sessions of a manualized group treatment called Social Cognition Interaction Training | Behavioral: Social Cognition Interaction Training<br>* manualized group therapy<br>|
| Other: 2 Wait List Control<br>Wait list control; 6 months of treatment as usual followed by Social Cognition Interaction Training group | Behavioral: WLC<br>* wait-list control for 6 months, followed by the experimental group therapy<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Social cognitive measures |  | intake, 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| basic cognitive measures |  | intake, 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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schizophrenia, social cognition, cognition, treatment, outcome