Investigating the Effect of Whole-fruit Coffee Extract on Exercise Performance

Study Overview
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Brief Summary
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Caffeine is a widely used efficacious supplement by both the general public, and athletes, with the goal of improving performance. The effects of caffeine alone are well known, but it is not clear whether a multi-ingredient supplement (containing both caffeine and polyphenols) can affect exercise performance. This study aims to determine if a low dose of caffeine, in the form of a whole-fruit coffee extract also containing polyphenols, can improve exercise performance compared to a placebo condition, with a secondary objective of identifying if this supplement can improve post exercise refuelling (glycogen resynthesis). Participants will consume either the supplement or a placebo before engaging in an exercise protocol. Muscle biopsies will then be obtained so as to measure subsequent glycogen resynthesis, with multiple blood samples being taken through the day. The following morning another biopsy will be taken before the exercise protocol will be repeated. This research will inform us of the efficacy of caffeine and polyphenols on improving exercise performance.

Official Title
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Investigating the Effect of Whole-fruit Coffee Extract on Exercise Performance

Conditions
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Caffine and Endurance Performance

Intervention / Treatment
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* Dietary Supplement: CoffeeBerry Supplement
* Dietary Supplement: Placebo


Participation Criteria
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Eligibility Criteria
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Exclusion criteria: Allergy to Lidocaine Exclusion critera Any diagnosed metabolic health condition Pregnant Non-habitual caffeine intake Smoker No endurance training Diagnosed Cardiovascular disease Beta-Blockers Recent history of musculoskeletal injury Inclusion criteria: Age 18-40 Heathy Highly trained endurance athletes (V̇O2max: males >55 and females >50 mL⋅kg bm-1⋅min-1) Both males and females are allowed to participate. If females are on the oral contraceptive pill they are to be tested on consecutive weeks. If they are not on the oral contraceptive pill, then female subjects are to be tested every 4 weeks, at the same point of their menstrual cycle.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: CoffeeBerry Supplement<br>Caffeine and polyphenol supplement | Dietary Supplement: CoffeeBerry Supplement<br>* A Coffeeberry supplement containing 200mg Caffeine and 14mg polyphenols, manufactured by FutureCeuticals Inc.,<br>|
| Placebo Comparator: Placebo<br>Placebo | Dietary Supplement: Placebo<br>* Placebo<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Exercise performance | Amount of work completed in 15 minutes | 15 Minitues | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Glycogen Resynthesis | The diffrence in glycogen within the muscle between two time points | 24 Hours | 
| Alertness | 10 cm visual analog scale (Ranging from Not Alert to Extremly Alert) | 1 Minitue | 
| Motivation | 10 cm visual analog scale (Ranging from Not motivated to Extremly motivated) | 1 Minitue | 
| Rate of perceived exertion | Validated Borg scale (6-20 Arbitrary units) | 1 Minitue | 
| Urine osmolarity | The hydration status of the individual measured in mOsmo|/kg | 24 Hours | 
| GI comfort | 10 cm visual analog scale (Ranging from No discomfort to Extreme discomfort) | 1 Minitue |