Does Moderate Physical Activity in Hemodialysis Patients Reduce Inflammation?

Study Overview
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Brief Summary
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The purpose of this study is to observe a potential benefit of moderate physical activity by using bed mounted cycles during hemodialysis treatment sessions on inflammatory markers in the blood of patients with end-stage renal disease (ESRD).

Detailed Description
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Patients with ESRD on chronic hemodialysis patients frequently have elevated markers of inflammation (e.g., serum CRP values) and accumulation of proinflammatory monocyte populations in the circulation. The level of inflammation is highly predictive for cardiovascular disease and mortality. Physical activity has been shown to improve dialysis efficacy by improving the elimination of retention solutes. In healthy individuals, sports activity influences inflammatory immune parameters. The study will observe the influence of moderate physical activity (using a bed mounted cycle for 30min during dialysis thrice weekly) on circulating monocyte subpopulations and inflammatory proteins over a 9 month period in 16 chronic hemodialysis patients.

Official Title
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Does Moderate Physical Activity in Chronic Hemodialysis Patients Reduce Inflammation Via Inhibition of Proinflammatory Monocyte Activity?

Conditions
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End-stage Renal Disease, Hemodialysis

Intervention / Treatment
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* Behavioral: moderate physical activity


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: chronic hemodialysis treatment for at least three months three dialysis sessions per week good general clinical condition stable hemodynamics during the most recent three dialysis sessions Exclusion Criteria: conditions making the patient unable to use the bed mounted cycle (amputations, joint disease etc) clinically obvious acute infections active malignancy pathologic results of spiroergometry or echocardiography that imply an elevated risk of participation myocardial infarction within the last 12 weeks uncontrolled arterial hypertension uncontrolled diabetes mellitis with frequent hypoglycemia unability to understand and consent the protocol

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| hemodialysis patients<br>chronic hemodialysis patients with elevated inflammation markers | Behavioral: moderate physical activity<br>* bed mounted cycles for physical activity for 30 min during each hemodialysis session<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Composition of monocyte subpopulations as defined by CD14 and CD16 expression |  | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Serum CRP values |  | 6 months | 
| Dialysis quality (kt/V, URR) |  | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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inflammation, cardiovascular disease