Treatment of Hepatocellular Carcinoma With Radiofrequency Ablation (RFA) Associated With Postoperative TACE

Study Overview
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Brief Summary
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A RCT was conducted to elucidate whether the treatment outcome of HCC could be improved by RFA associated with postoperative TACE.

Detailed Description
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A randomized study was conducted to elucidate whether the outcome of hepatocellular carcinoma could be improved by radiofrequency ablation associated with postoperative transhepatic arterial chemoembolization.

Official Title
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Treatment of Hepatocellular Carcinoma With Radiofrequency Ablation Associated With Postoperative Transhepatic Arterial Chemoembolization--a Prospective Randomized Clinical Trial

Conditions
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Cancer of Liver

Intervention / Treatment
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* Procedure: radiofrequency ablation associated with TACE
* Procedure: radiofrequency ablation only


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients with hepatocellular,confirmed by pathological examination patients with a live function test showed Child A or B Indocyanine green test showed less than 30％ after 15min,and the patients showed a tolerance of RFA and TACE Tumor stage is early period(according to Milan Standard),that is,the diameter of single node should be less than 5cm；the node of tumor should be less than 3 and the diameter less than 3cm. without metastasis in lymphnode or other organs written consent inform assigned Exclusion Criteria: preoperative examination showed malignant thrombosis in the first class branch of portal vein or hepatic vein or vena cava metastatic cancer of liver patients with a poor tolerance of RFA and TACE patients received other therapies.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: RFA+TACE<br>treatment of hepatocellular carcinoma by radiofrequency ablation associated with postoperative transhepatic arterial chemoembolization | Procedure: radiofrequency ablation associated with TACE<br>* treatment of hepatocellular carcinoma by radiofrequency ablation associated with postoperative transhepatic arterial chemoembolization<br>* Other names: Group A;|
| Active Comparator: RFA only<br>treatment of hepatocellular carcinoma by radiofrequency ablation only | Procedure: radiofrequency ablation only<br>* treatment of hepatocellular carcinoma by radiofrequency ablation only<br>* Other names: Group B;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| disease free survival |  | 3 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| overall survival |  | 3 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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radiofrequency ablation, Cancer of Liver, postoperative, transhepatic arterial chemoembolization, prospective