Investigation of the Efficacies of Multi Berries Juice on Anti Oxidant Effect and Improvement of Skin Conditions

Study Overview
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Brief Summary
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To assess multi berries juice on anti-oxidant effect and skin condition improvement

Official Title
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Investigation of the Efficacies of Multi Berries Juice on Anti Oxidant Effect and Improvement of Skin Conditions

Conditions
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Skin Condition, Anti Oxidative Stress

Intervention / Treatment
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* Dietary Supplement: multi berries juice
* Dietary Supplement: Placebo drink


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy adults aged above 20 years old Exclusion Criteria: Subject who is not willing to participate in this study. Patients with diseases of the skin, liver, kidney. Subjects who have known cosmetic, drug or food allergies, difficulty in digestive tract absorption or disorder. Female who is pregnant or nursing or planning to become pregnant during the course of the study. Received facial laser therapy, chemical peeling or UV overexposure in the past 4 weeks. Constant drug use

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Placebo drink<br> | Dietary Supplement: Placebo drink<br>* Blank<br>|
| Experimental: multi berries juice<br> | Dietary Supplement: multi berries juice<br>* Testing product<br>* Other names: Sei Bella™ Pure Essence Whitening Multi-Berries Drink;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The change of skin UV spots | VISIA Complexion Analysis System was utilized to measure skin UV spots. Units: arbitrary units | Change from Baseline skin UV spots at 8 weeks | 
| The change of skin melanin index | Soft Plus was utilized to measure skin melanin index. Units: arbitrary units | Change from Baseline skin melanin index at 8 weeks | 
| The change of blood SOD content | Venous blood was sampled to measure concentrations of SOD | Change from Baseline SOD content at 8 weeks | 
| The change of blood total antioxidant capacity (TAC) | Venous blood was sampled to measure concentrations of TAC | Change from Baseline TAC at 8 weeks | 
| The change of skin L* value | Chroma Meter MM500 was utilized to measure skin L* value. Units: arbitrary units, 0-100 | Change from Baseline L* value at 8 weeks | 
| The change of skin spots | VISIA Complexion Analysis System was utilized to measure skin spots. Units: arbitrary units | Change from Baseline skin spots at 8 weeks | 
| The change of skin brown spots | VISIA Complexion Analysis System was utilized to measure skin brown spots. Units: arbitrary units | Change from Baseline skin brown spots at 8 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The change of skin moisture | Corneometer® CM825 was utilized to measure skin moisture. Units: arbitrary Corneometer® units 0-120 | Change from Baseline skin moisture at 4 weeks | 
| The change of skin a* value | Chroma Meter MM500 was utilized to measure skin a* value. Units: arbitrary units | Change from Baseline a* value at 8 weeks | 
| The change of skin elasticity | Soft Plus was utilized to measure skin elasticity. Units: arbitrary units | Change from Baseline skin elasticity at 8 weeks | 
| The change of skin wrinkles | VISIA Complexion Analysis System was utilized to measure skin wrinkles. Units: arbitrary units | Change from Baseline skin wrinkles at 8 weeks | 
| The change of skin texture | VISIA Complexion Analysis System was utilized to measure skin texture. Units: arbitrary units | Change from Baseline skin texture at 8 weeks | 
| The change of skin pores | VISIA Complexion Analysis System was utilized to measure skin pores. Units: arbitrary units | Change from Baseline skin pores at 8 weeks | 
| The change of skin collagen density | DermaLab® Series SkinLab Combo was utilized to measure skin collagen density. Units: arbitrary units | Change from Baseline skin collagen density at 8 weeks |