Blood Samples From Healthy Volunteers for Genetic Studies in the East Anglia Region of the United Kingdom

Study Overview
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Brief Summary
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RATIONALE: Studying samples of blood from healthy volunteers in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This study is looking at genetic susceptibility to cancer and interactions between genes and the environment in healthy volunteers.

Detailed Description
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OBJECTIVES: To obtain blood samples and simple epidemiological information on a population-based series of adult individuals without cancer. To establish whether polymorphisms in putative cancer predisposition genes are associated with an increased risk of cancer by comparing the frequency of alterations in these genes with the corresponding frequency in a comparable series of cancer patients. To examine the interactions between genetic and non-genetic risk factors. OUTLINE: This is a multicenter study. Participants complete a simple epidemiological questionnaire. Participants undergo blood sample collection. DNA is extracted from these samples for polymorphism analysis of low penetrance cancer susceptibility genes in the following related clinical trials: MREC-SEARCH-CANCER, MREC-SEARCH-PROSTATE, and MREC-SEARCH-BREAST. They may also be used in the analyses of the following related clinical trials: MREC-SEARCH-OVARIAN, MREC-SEARCH-ENDOMETRIAL, MREC-SEARCH-COLORECTAL. PROJECTED ACCRUAL: A total of 2,000 male and 2,000 female participants will be accrued for this study.

Official Title
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A Population Based Control Collection for Genetic Studies in East Anglia

Conditions
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Healthy, no Evidence of Disease

Intervention / Treatment
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* Genetic: polymorphism analysis
* Other: laboratory biomarker analysis
* Other: questionnaire administration


Participation Criteria
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Eligibility Criteria
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DISEASE CHARACTERISTICS: Cancer-free participants randomly selected from the age-sex registry of a general practice in the East Anglia region of the United Kingdom Two general practices from each district within East Anglia participate (up to 10 total participating practices) PATIENT CHARACTERISTICS: Identified by the participant's general practitioner as fit to contact for this study No prior diagnosis of cancer No serious mental illness or retardation PRIOR CONCURRENT THERAPY: Not specified

Ages Eligible for Study
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Minimum Age: 35 Years
Maximum Age: 69 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Genetic: polymorphism analysis|nan|
|Other: laboratory biomarker analysis|nan|
|Other: questionnaire administration|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Acquisition of blood samples and epidemiological information |  |  | 
| Investigation of whether polymorphisms in putative cancer predisposition genes are associated with an increased risk of cancer |  |  | 
| Examination of the interactions between genetic and nongenetic risk factors |  |  | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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healthy, no evidence of disease