RGB(Red- Green-Blue) Measurement of the Nasal Mucosal Image

Study Overview
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Brief Summary
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The aim of this study was to evaluate the color values of the nasal mucosa, which is easily assessable by a direct, non-invasive, objective photographic measurement, for the purpose of presenting a diagnostic objective parameter of allergic rhinitis (AR). All patients and controls were examined by the same 4 mm 0⁰endoscope and light source, and all endoscopic photographs of the septum and both inferior turbinates were taken. Adobe Photoshop Elements 7.0 program was used to measure the numerical values of the red-green-blue (RGB) color components in endoscopic photographs of the nasal mucosa on the septum and inferior turbinates.

Detailed Description
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This study enrolled 73 patients with AR (Group 1) and 73 normal healthy individuals(Group 2) with no nasal pathologies and respiratory tract infection attending to the outpatient clinic of the tertiary referral center. Patient's symptoms were questioned and noted by using Lebel Symptom Score Scale. Clinical examination was also done to help diagnose and exclude acute respiratory tract infection. All of the patients had positive skin prick test results for at least one of the most common aeroallergens. All patients and controls were examined by the same 4 mm 0⁰endoscope and light source, and all endoscopic photographs of the septum and both inferior turbinates were taken. Each image was marked with standardized points at the anterior part of the nasal mucosa on both sides (2 points each right and left sides of the anterior septum and 2 points each anterior part of the inferior turbinates). These points were numbered 1 and 2 over the right inferior turbinate; 3 and 4 over the right side of the anterior septum; 4 and 5 over the left inferior turbinate; 6 and 7 over the left side of the anterior septum. Adobe Photoshop Elements 7.0 program was used to measure the numerical values of the red-green-blue color components in endoscopic photographs of the nasal mucosa on the septum and inferior turbinates.

Official Title
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RGB(Red- Green-Blue) Measurement of the Nasal Mucosal Image: A New Diagnostic Parameter for Allergic Rhinitis

Conditions
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Allergic Rhinitis

Intervention / Treatment
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* Other: Red-green-blue measurements of nasal mucosa image


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Subject has positive skin prick test results Subject has more than 5 points of Lebel Symptom Score Scale Subjects between 18-60 ages Subjects with allergic rhinitis Exclusion Criteria: Negative skin prick test results Acute respiratory tract infection existence Scores less than 5 points of Lebel Symptom Score Scale

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group 1<br>Red-green-blue measurements of nasal mucosa images of patients with allergic rhinitis | Other: Red-green-blue measurements of nasal mucosa image<br>* Adobe Photoshop Elements 7.0 program automatically measures the numerical values of the RGB color components in the selected area<br>|
| Group 2<br>Red-green-blue measurements of nasal mucosa images of normal healthy individuals | Other: Red-green-blue measurements of nasal mucosa image<br>* Adobe Photoshop Elements 7.0 program automatically measures the numerical values of the RGB color components in the selected area<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The difference of nasal mucosa color between groups | Nasal mucosa colors of the groups were measured with the numerical values of the RGB color components. All endoscopic photographs of the septum and both inferior turbinates of the patients and healthy individuals were taken while the examination at the outpatient clinic for three months. Adobe Photoshop Elements 7.0 program automatically measures the numerical values of the RGB color components in the pointed area. Color discoloration at the nasal mucosa of allergic patients compared with the healthy individuals by using RGB measurements. | 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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RGB, red-green-blue, rhinitis, allergic rhinitis, nasal mucosa