Driving Pressure in Laparoscopic Surgery

Study Overview
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Brief Summary
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The effect of driving pressure (DP)-guided positive end expiratory pressure (PEEP) on early postoperative pulmonary ventilation is to be determined for patients undergoing laparoscopic surgery. Patients are recruited to receive volume controlled ventilation with either a fixed PEEP (5cmH2O) or DP titrated PEEP. Early postoperative regional distribution of lung ventilation, expressed as center of ventilation (COV) is evaluated by electrical impedance tomography (EIT), a noninvasive, radiation free modality. Perioperative ventilatory parameters, arterial oxygenation index (PaO2/FiO2) , serum indicators and postoperative pulmonary complications are secondary outcome variables.

Detailed Description
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After screened for preoperative risk factors, 48 patients undergoing elective laparoscopic surgery and planned to be extubated in the operating room are randomly assigned to two groups: (1) PEEP = 5cmH2O; (2) driving pressure (DP)-guided PEEP. The ventilation protocol consists of volume-controlled mechanical ventilation (Datex Ohmeda S/5 Advance; General Electric Company Healthcare, Helsinki, Finland) at a tidal volume (VT) of 8 ml/kg predicted body weight (PBW), fresh gas of 2 litre /min, inspiratory to expiratory ratio of 1:2, and a respiratory rate adjusted to normocapnia (arterial carbon dioxide partial pressure between 35 and 45 mmHg). For group 2, trial for the lowest DP was started 10 min after pneumoperitoneum and position adjustment by increasing PEEP from 5 to 15 cm H2O incrementally. DP was calculated as plateau pressure - PEEP. Each PEEP level was maintained for 10 respiratory cycles, with DP in the last cycle recorded. Then the PEEP level producing the lowest DP was identified and maintained intraoperatively. A plateau pressure of no more than 30 cmH2O is targeted in each group. Early postoperative distribution of regional ventilation as COV (center of ventilation) is the primary endpoint evaluated by EIT (electrical impedance tomography), which was performed by a trained technician who is blinded to randomization. Arterial blood gas is tested, with inflammatory and oxidative mediators from venous sample. Postoperative pulmonary complications within 3 days are also recorded.

Official Title
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Driving Pressure for Early Postoperative Redistribution of Pulmonary Ventilation in Laparoscopic Surgery : A Prospective Randomized Controlled Trial

Conditions
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Laparoscopy

Intervention / Treatment
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* Procedure: PEEP


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Informed consent has been obtained Elective laparoscopic surgery with Trendelenburg position Expected ventilation duration > 2 hours Scheduled to be extubated in the operation Exclusion Criteria: Mechanical ventilation of > 1 hour within the last 2 weeks before surgery Body mass index ≥ 35 kg/m2 Acute respiratory failure (pneumonia, acute lung injury or acute respiratory distress syndrome) Emergency surgery Severe cardiac disease Progressive neuromuscular illness Pregnancy Refusal to participate Contradicted to EIT scan

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Conventional PEEP<br>PEEP = 5 cmH2O | Procedure: PEEP<br>* different PEEP set on the anesthetic machine<br>|
| Experimental: Driving pressure (DP) guided-PEEP<br>DP is calculated as plateau pressure - PEEP. 10 min after pneumoperitoneum， PEEP is increased from 5 to 15 cm H2O incrementally. Each PEEP level is maintained for 10 respiratory cycles, with DP in the last cycle recorded. Then the PEEP level producing the lowest DP will be identified and maintained intraoperatively. | Procedure: PEEP<br>* different PEEP set on the anesthetic machine<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| early postoperative overall spatial distribution of pulmonary ventilation | global inhomogeneity index (GI): overall degree of spatial heterogeneity of ventilation. GI is measured by electrical impedance tomography (EIT). A smaller GI index represents a more homogeneous distribution, and a larger GI index indicates a more inhomogeneous ventilation. | immediately after extubation |