Thoracolumbal Interfascial Plane Block Versus Erector Spinae Plane Block for Lumbar Posterior Decompression Stabilization

Study Overview
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Brief Summary
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This study aimed to found out The Comparison Of Perioperative Analgesia Effectiveness Between Thoracolumbal Interfascial Plane Block with Erector Spinae Plane Block In Lumbar Posterior Decompression and Stabilization.

Detailed Description
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This is a double blind randomized controlled trial. Forty subject will be recruited with non-probability consecutive sampling method. Subjects who meet all inclusion criteria and do not have exclusion criteria will be asked to sign the informed consent form before included in this study. Subjects will be randomized into two groups. The first group is the group who will get Bilateral Thoracolumbal Interfascial Plane Block after general anesthesia and the second group will be the group who will get Bilateral Erector Spinae Plane Block after general anesthesia. After surgery, pain scale, time to first morphine dose, total morphine consumption in 24 hours, cardiovascular stability and adverse events will be recorded for both group.

Official Title
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Comparison of Perioperative Analgesia Effectiveness Between Thoracolumbal Interfascial Plane Block With Erector Spinae Plane Block In Lumbar Posterior Decompression and Stabilization: A Study to Interleukin-6 and Interleukin-10 Plasma Concentration, Pain Scale, Total Opioid Consumption, and Cardiovascular Stability

Conditions
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Lumbar Posterior Decompression

Intervention / Treatment
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* Procedure: Thoracolumbar interfacial plane (TLIP) Block
* Procedure: Erector Spinae Plane (ESP) Block


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 18 - 65 years old Patients schedule for elective posterior decompression and stabilization lumbar spine surgery ASA I - III Decompression and posterior stabilization's patients who didn't caused by infection or abscess Exclusion Criteria: Patients who refuse to participate in this study Body Mass Index < 18,5 kg/m2 and > 27,0 kg/m2 Patient with history of chronic opioid Patient with coagulation disorder Patient with cognitive disorders Infection at the injection area

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Thoracolumbar interfacial plane (TLIP) Block<br>Thoracolumbar interfacial plane (TLIP) Block will be performed after induction of anesthesia by anesthesiologist who is not part of investigators for this study. Bilateral 20 ml 0.25 % Bupivacaine injected between multifidus and longissimus muscle with Ultrasound guidance. | Procedure: Thoracolumbar interfacial plane (TLIP) Block<br>* TLIP Block: Bilateral 20 ml 0.25 % Bupivacaine injected between multifidus and longissimus muscle with Ultrasound guidance.<br>Procedure: Erector Spinae Plane (ESP) Block<br>* ESP Block: Bilateral 20 ml 0.25 % Bupivacaine injected between the erector spinae muscles and transverse process with Ultrasound guidance.<br>|
| Active Comparator: Erector Spinae Plane (ESP) Block<br>Erector Spinae Plane (ESP) Block will be performed after induction of anesthesia by anesthesiologist who is not part of investigators for this study. Bilateral 20 ml 0.25 % Bupivacaine injected between the erector spinae muscles and transverse process with Ultrasound guidance | Procedure: Thoracolumbar interfacial plane (TLIP) Block<br>* TLIP Block: Bilateral 20 ml 0.25 % Bupivacaine injected between multifidus and longissimus muscle with Ultrasound guidance.<br>Procedure: Erector Spinae Plane (ESP) Block<br>* ESP Block: Bilateral 20 ml 0.25 % Bupivacaine injected between the erector spinae muscles and transverse process with Ultrasound guidance.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from baseline Interleukin-6 and Interleukin-10 at 6 hours after Lumbar Posterior Decompression and Stabilization | Measure by ELISA | Before surgery and 6 hours after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| investigators will record total morphine dose needed in 24 hours | investigators will record time to first morphine dose after surgery | 24 hours after surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Thoracolumbal Interfascial Plane Block, Erector Spinae Plane Block, Lumbar Posterior Decompression and Stabilization