Early Vascular Ageing in the YOUth

Study Overview
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Brief Summary
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This is a single-center observational study on adolescents to determine predictors of the early steps of the formation of atherosclerosis and to quantify their influence on Intima-Media-Thickness of the carotid artery and the aorta and on the Pulse-Wave Velocity. A long-term follow-up by means of record linkage is furthermore planned to evaluate the effect of early atherosclerosis and the cardiovascular risk profile on future morbidity with a special focus cardio- and cerebrovascular events.

Detailed Description
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EVA4YOU is a cross-sectional study enrolling 3000 students and apprentices aged between 14 and 19 years. Examinations are conducted at schools and companies throughout Tyrol, Austria and include laboratory measurements; standardized medical interviews; anthropometry; liver elastography; ultrasonography of the carotid artery and the aorta, and blood pressure, bioelectrical impedance; visceral abdominal fat-tissue-thickness measurement, pulse-wave velocity measurements. The study hypothesis is that the cardiovascular risk factors measured already influence the formation of atherosclerosis (measured as carotid and aortic Intima-Media Thickness and Pulse-Wave-Velocity) in adolescents. A long-term follow-up by means of record linkage is furthermore planned to evaluate the effect of early atherosclerosis and the cardiovascular risk profile on future morbidity with a special focus cardio- and cerebrovascular events.

Official Title
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Early Vascular Ageing in the YOUth - An Observational Study Into the Predictors of Atherosclerotic Changes in Adolescents

Conditions
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Atherosclerosis, Cardiovascular Risk Factor, Cardiovascular Diseases, Cardiovascular Pathology, Life Style, Vascular Diseases, Vascular Stiffness, Non-Alcoholic Fatty Liver Disease, Hypertension, Obesity, Overweight, Headache, Sleep, Sleep Disorder

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adolescents at the age of 14 to 19 years Signed informed consent of subjects (and legal guardian if subject < 18 years of age) Exclusion Criteria: Persons, who are suspended upon a court order or upon other legal processes or are accommodated according to the Hospitalization Act, or for whom a custodian is appointed (or appointment is initiated). Persons with impaired power of judgment Persons who are currently engaged in military or community service

Ages Eligible for Study
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Minimum Age: 14 Years
Maximum Age: 19 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Determinants of Intima-Media Thickness (carotid and aortic) | Predictors to be examined include: Blood Pressure, BMI/body composition, Smoking, Physical Activity, Family History, Lipid and Glucose Metabolism, NAFLD, Diet, Sex, Age used as predictors in multiple regression analysis | Day 1 | 
| Determinants of the Pulse-Wave Velocity [m/s] | Predictors to be examined include: Blood Pressure, BMI/body composition, Smoking, Physical Activity, Family History, Lipid and Glucose Metabolism, NAFLD, Diet, Sex, Age used as predictors in multiple regression analysis The pulse-wave velocity [m/s] is measured by using the Vicorder, an oscillometric pulse-wave measurement device. | Day 1 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Predictors of later cardio- and cerebrovascular disease (events and mortality) by record linkage | Occurence of major adverse cardiovascular events (yes/no, time to event), assessed by means of automated detection of these events by record linkage | every 2-5 years, on average for the duration of 50 years | 
| Prevalence of traditional cardiovascular risk and lifestyle factors and descripition of high-risk populations |  | Day 1 | 
| Time trends in risk profiles by comparison to data from the Early Vascular Ageing (EVA) study, NCT03929692 |  | 8 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cardiovascular Diseases, Cardiovascular Risk Factor, Atherosclerosis, Cardiovascular Pathology, Life Style, Vascular Diseases, Early Vascular Ageing, Vascular Stiffness, Intima-Media Thickness, Non-Alcoholic Fatty Liver Disease, Ultrasonography, Liver Elastography, Bioimpedance, Blood Pressure, Body Mass Index, Headache, Sleep, Adolescence