Echographic Measurement of Skin Thickness

Study Overview
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Brief Summary
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To optimize a medical device for intradermal injection, knowledge concerning the thickness of epidermis and dermis at the proximal forearm is required. Since scientific knowledge is lacking, the investigators will examine the skin thickness (epidermis and dermis) of adults using imaging technology (High Frequency Ultrasound). The investigators hypothesize that they are able to correlate the thickness of the (epi)dermis to a specific combination of parameters age, gender, and BMI. Based on these results, the investigators can define which needle type and length is needed to correctly perform injections into the dermal layer.

Official Title
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Echographic Measurement of Skin Thickness at the Deltoid and Proximal Forearm in Adults

Conditions
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Skin Thickness

Intervention / Treatment
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* Other: Echographic measurement of skin thickness


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy adults Age: 18-65 years Dutch-speaking Caucasian Exclusion Criteria: Pregnancy or lactating Using ointment, crème, or gels based on corticoids Suffering from skin diseases (psoriasis, burning wounds)

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Participants aged 18-30 years<br>Echographic measurement of skin thickness at the proximal forearm and the deltoid region in participants aged 18-30 years. aimed number: 12 male & 12 female maximum number: 15 male & 15 female | Other: Echographic measurement of skin thickness<br>* (Epi)Dermal thickness at the proximal forearm and the deltoid region will be measured using imaging technology, more specifically high-frequency ultrasound (20-40 MHz) in B-mode (VEVO 2100®, Visual Sonics). This non-invasive measuring technique has already been proven to be accurate. The echographic measurement will be performed on the left and right deltoid region and on two sides of the proximal forearm. Both the dorsal part and the volar/palmar part of the proximal forearm will be investigated. Ultrasound will be executed using gel (Aquasonic®) to optimize imaging.<br>|
| Participants aged 31-40 years<br>Echographic measurement of skin thickness at the proximal forearm and the deltoid region in participants aged 31-40 years. aimed number: 12 male & 12 female maximum number: 15 male & 15 female | Other: Echographic measurement of skin thickness<br>* (Epi)Dermal thickness at the proximal forearm and the deltoid region will be measured using imaging technology, more specifically high-frequency ultrasound (20-40 MHz) in B-mode (VEVO 2100®, Visual Sonics). This non-invasive measuring technique has already been proven to be accurate. The echographic measurement will be performed on the left and right deltoid region and on two sides of the proximal forearm. Both the dorsal part and the volar/palmar part of the proximal forearm will be investigated. Ultrasound will be executed using gel (Aquasonic®) to optimize imaging.<br>|
| Participants aged 41-50 years<br>Echographic measurement of skin thickness at the proximal forearm and the deltoid region in participants aged 41-50 years. aimed number: 12 male & 12 female maximum number: 15 male & 15 female | Other: Echographic measurement of skin thickness<br>* (Epi)Dermal thickness at the proximal forearm and the deltoid region will be measured using imaging technology, more specifically high-frequency ultrasound (20-40 MHz) in B-mode (VEVO 2100®, Visual Sonics). This non-invasive measuring technique has already been proven to be accurate. The echographic measurement will be performed on the left and right deltoid region and on two sides of the proximal forearm. Both the dorsal part and the volar/palmar part of the proximal forearm will be investigated. Ultrasound will be executed using gel (Aquasonic®) to optimize imaging.<br>|
| Participants aged 51-65 years<br>Echographic measurement of skin thickness at the proximal forearm and the deltoid region in participants aged 51-65 years. aimed number: 12 male & 12 female maximum number: 15 male & 15 female | Other: Echographic measurement of skin thickness<br>* (Epi)Dermal thickness at the proximal forearm and the deltoid region will be measured using imaging technology, more specifically high-frequency ultrasound (20-40 MHz) in B-mode (VEVO 2100®, Visual Sonics). This non-invasive measuring technique has already been proven to be accurate. The echographic measurement will be performed on the left and right deltoid region and on two sides of the proximal forearm. Both the dorsal part and the volar/palmar part of the proximal forearm will be investigated. Ultrasound will be executed using gel (Aquasonic®) to optimize imaging.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| skin thickness (in milimeters) of the proximal forearm dorsal (both left and right) |  | 10 minutes | 
| skin thickness (in milimeters) of the proximal forearm ventral (both left and right) |  | 10 minutes | 
| skin thickness (in milimeters) of the deltoid region (both left and right) |  | 10 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Body Mass Index |  | at the moment of entering the study | 
| Age |  | at the moment of entering the study | 
| sex |  | at the moment of entering the study | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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skin thickness, high-frequency ultrasound