Inflammatory Markers: HOLEP Versus TURP

Study Overview
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Brief Summary
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Aim of the study is to compare the systemic inflammatory markers and surgical stress response in patients undergoing HOLEP or TUR-P surgery.

Detailed Description
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Benign prostatic hyperplasia (BPH) is the most common disease in aging men worldwide, causing significant difficulties and resulting in bladder outlet obstruction. Basically, surgical techniques in patients with BPH are transurethral resection of the prostate (TURP), holmium laser enucleation of the prostate (HOLEP), and open prostoactemy surgery. There are many studies comparing the clinical outcomes of TURP and HOLEP surgery. However, to the best of our knowledge, there has not been a study comparing the effects of these two types of surgery on inflammatory markers and stress hormones.

Official Title
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Comparison of Surgical Stress in Patients Undergoing TURP Versus HOLEP Surgery by Measuring Perioperative Systemic Inflammatory Markers

Conditions
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Prostate Hyperplasia

Intervention / Treatment
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* Procedure: Surgery method


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ASA scores I-III patients having benign prostatic hyperplasia undergoing HOLEP or TURP surgery under general anesthesia Exclusion Criteria: immune system disease, diabetes mellitus, malignancy other than prostate disease, history of steroid use,
Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: HOLEP<br>Patients with a prostate volume greater than 80 g | Procedure: Surgery method<br>* Patients were subdivided into two groups according to their prostate volume<br>|
| Active Comparator: TURP<br>Patients with a prostate volume less than 80 g | Procedure: Surgery method<br>* Patients were subdivided into two groups according to their prostate volume<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| inflamatory markers | WBC (109 /L) | Change from baseline WBC (109 /L) at postoperative 0th and postoperative 24th hour | 
| Stress hormone levels | Adrenaline (ng/L) | Change from baseline adrenaline (ng/L) at postoperative 0th and postoperative 24th hour | 
| inflamatory markers | CRP | Change from baseline CRP (mg/L) at postoperative 0th and postoperative 24th hour | 
| inflamatory markers | IL-6 (pg/ml) and TNF-alfa (pg/ml) | Change from baseline IL-6 (pg/ml) and TNF-alfa (pg/ml), at postoperative 0th and postoperative 24th hour | 
| inflamatory markers | CD4+/CD8+ | Change from baseline CD4+/CD8+ at postoperative 0th and postoperative 24th hourL-6 (pg/ml) and TNF-alfa (pg/ml) | 
| stress hormone levels | Cortisol (microg/dl) | Change from baseline cortisol (microg/dl) at postoperative 0th and postoperative 24th hour |