Analysis of Inflammation in the Vitiligo and Other Inflammatory Skin Diseases: Psoriasis, Atopic Dermatitis and Alopecia Areata

Study Overview
=================
Brief Summary
-----------------
It is a study of translational research with mechanistically objectives and including biological samples of patients with chronic inflammatory disorders

Detailed Description
-----------------
This study was a single-center prospective study to collect blood and skin tissue at the time of consultation with a patient with non-segmental vitiligo, psoriasis, atopic dermatitis or alopecia areata, in order to better understand and compare blood and skin immune response in chronic inflammatory skin disorders: psoriasis, alopecia areata, atopic dermatitis and vitiligo.

Official Title
-----------------
Analysis of Inflammation in the Vitiligo and Other Inflammatory Skin Diseases: Psoriasis, Atopic Dermatitis and Alopecia Areata

Conditions
-----------------
Vitiligo, Psoriasis, Alopecia Areata, Atopic Dermatitis

Intervention / Treatment
-----------------
* Biological: Blood samples
* Biological: Skin biopsies


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients aged 18 to 75 years; Patients with non-segmental vitiligo; Patients with plaque psoriasis; Patients with atopic dermatitis; Patients with alopecia areata sclerosis; written consent, free, informed and signed by the patient and the investigator (before any examination required by the study); Subject affiliated or beneficiary of a social security system. Exclusion Criteria: Patients with segmental vitiligo Patients under local treatment (topical corticosteroid-Calcineurin inhibitor) for less than two weeks. Patients on therapy, systemic treatments: acitretin, methotrexate, cyclosporine, Apremilast, infliximab, adalimumab, etanercept, ustekinumab, secukinumab, ixekizumab, dupilumab) for less than 4 weeks. Pregnant or breastfeeding women Patient (e) under guardianship Patient (e) Non-affiliated (e) a social protection

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| vitiligo<br>Patients aged 18 to 75 years with non-segmental vitiligo; | Biological: Blood samples<br>* Blood samples: serum and PBMC<br>* Other names: Blood samples: serum and PBMC;Biological: Skin biopsies<br>* These superficial skin biopsies under local anesthesia in skin areas with the exception of the face and folds.<br>|
| psoriasis<br>Patients aged 18 to 75 years with plaque psoriasis; | Biological: Blood samples<br>* Blood samples: serum and PBMC<br>* Other names: Blood samples: serum and PBMC;Biological: Skin biopsies<br>* These superficial skin biopsies under local anesthesia in skin areas with the exception of the face and folds.<br>|
| atopic dermatitis<br>Patients aged 18 to 75 years with atopic dermatitis; | Biological: Blood samples<br>* Blood samples: serum and PBMC<br>* Other names: Blood samples: serum and PBMC;Biological: Skin biopsies<br>* These superficial skin biopsies under local anesthesia in skin areas with the exception of the face and folds.<br>|
| alopecia areata<br>Patients aged 18 to 75 years with alopecia areata sclerosis; | Biological: Blood samples<br>* Blood samples: serum and PBMC<br>* Other names: Blood samples: serum and PBMC;Biological: Skin biopsies<br>* These superficial skin biopsies under local anesthesia in skin areas with the exception of the face and folds.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Description of the phenotype and function of blood and skin T-cell in chronic inflammatory skin disorders: psoriasis, vitiligo, atopic dermatitis, alopecia areata | Description of the phenotypic analysis of cutaneous T-cell and blood of vitiligo patients evaluated by flow cytometry | Day 1 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Skin inflammation, Cytokines