Oxygenation of Paravertebral Muscles During Exercise in Chronic Low Back Pain Patients

Study Overview
=================
Brief Summary
-----------------
The study evaluate paraspinal aerobic metabolism of chronic low back pain patients and healthy people during an original and standardized isokinetic protocol. The aim of this study is to determine a potential alteration of muscular aerobic metabolism in low back pain patients, in order to establish the underlying cause of pain and muscular fatigability characterizing low back pain patients. Then, the aim is to determine if functional rehabilitation program can improve it. the unit of care have access to metabolic adaptations in measuring the muscular oxygenation and the pulmonary oxygen consumption, using near infrared spectroscopy and gas analyser.

Official Title
-----------------
Oxygenation of Paravertebral Muscles During Exercise in Chronic Low Back Pain Patients

Conditions
-----------------
Low Back Pain, Rehabilitation Program, Muscular Weakness

Intervention / Treatment
-----------------
* Other: Physical rehabilitation program


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: For Low back pain patients: suffering from low back pain for at least 3 month For control subject: no back pain in the past year Exclusion Criteria: Chronic cardiovascular, pulmonary, metabolic, neurologic disease

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Factorial Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Low back pain patients<br>Subjects included in physical rehabilitation program. | Other: Physical rehabilitation program<br>* Patients participate during 4 weeks to a physical rehabilitation program.<br>|
| No Intervention: Control subjects<br>No intervention administered | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Deoxyhemoglobin | Expressed in arbitrary unit, at rest and during the isokinetic exercises (2 exercises of 5 minutes) | 20 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Oxygen consumption | Measured in mL/min/kg, at rest and during the isokinetic exercises (2 exercises of 5 minutes) | 20 minutes | 
| Work rate | Total work measured by the dynamometer in Joules during each exercises | 10 minutes | 
| Rate of perceived exertion | Bases on the Borg's Scale, evaluating the perceived exertion on a scale from 6 to 20 | 10 minutes | 
| Pain | Bases on a visual analogic scale evaluating the pain on a scale from 0 to 10 | 10 minutes | 
| Muscular blood volume | Expressed in arbitrary unit, at rest and during the isokinetic exercises (2 exercises of 5 minutes) | 20 minutes | 
| Sorensen test | test is a timed measure used to assess the endurance of the trunk extensor muscles. It is used to assist in the prediction of the incidence and occurrence of low back pain in patients. | 20 minutes | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Isokinetic, oxygenation, deoxygenation, aerobic metabolism