Efficacy of Lyophilized Food Extracts for Skin Prick Tests and Atopy Patch Test at Different Storage Time

Study Overview
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Brief Summary
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Comparison the result of skin prick tests and atopy patch test of lyophilized food extracts at different storage time (0, 3 and 6 months) after preparation

Detailed Description
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Skin prick test were performed with lyophilized food extracts (cow milk, egg white, egg yolk, wheat, soy and shrimp) at different storage time (0, 3 and 6 months) after preparation. Atopy patch test were performed with lyophilized food extracts (cow milk, egg white, egg yolk, wheat, soy and shrimp) at different storage time (0, 3 and 6 months) after preparation

Official Title
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Comparison of Skin Prick Tests and Atopy Patch Test Results of Lyophilized Food Extracts at Different Storage Time (0, 3 and 6 Months) After Preparation

Conditions
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Food Allergy

Intervention / Treatment
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* Diagnostic Test: skin test with food at different storage times


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: mild to moderately severe food allergy patients At least positive skin test to one kind of common food (commercial extract) Stop antihistamine or corticosteroid (if more than 20mg/day) for at least 7 days Exclusion Criteria: Dermographism Severe systemic disease such as autoimmune disease, immune deficiency, malignancy Severe dermatitis or large area involment pregnancy

Ages Eligible for Study
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Minimum Age: 3 Years
Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Perform skin prick test and atopy patch test of lyophilized foods (cow milk, egg white, egg yolk, wheat, soy and shrimp) stored at different time; 0, 3 and 6 months after preparation. Then compare the results.
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Food skin tests at 0 month<br>the skin test results of food extract at time 0 months after preparation | Diagnostic Test: skin test with food at different storage times<br>* Perform skin tests to each foods at 0, 3, 6 months after preparation and compare the results<br>|
| Active Comparator: Food skin tests at 3 month<br>the skin test results of food extract at time 3 months after preparation | Diagnostic Test: skin test with food at different storage times<br>* Perform skin tests to each foods at 0, 3, 6 months after preparation and compare the results<br>|
| Active Comparator: Food skin tests at 6 month<br>the skin test results of food extract at time 6 months after preparation | Diagnostic Test: skin test with food at different storage times<br>* Perform skin tests to each foods at 0, 3, 6 months after preparation and compare the results<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| skin test result of lyophilized foods at 6 months after preparation | Perform skin prick test and atopy patch test the patients with lyophilized foods at 0, 3 and 6 months after preparation and compare the results at 6 months to 0 and 3 months. | 6 month |