Efficacy and Safety of Products Containing Marine Collagen Peptide and Coenzyme Q10 for Skin Rejuvenation

Study Overview
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Brief Summary
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This is a placebo-controlled study conducted to investigates the safety and efficacy of products containing marine collagen peptide and CoQ10 in enhancing skin rejuvenation of Malaysian women. The study duration is 28 days and the skin assessment will be carried out at baseline, Day 14 and Day 28.The main questions it aims to answer are: The effect of product on skin hydration of women in Malaysia. The effect of product on skin elasticity of women in Malaysia. The effect of product on skin wrinkle of women in Malaysia. The skin brightening effect of product on Malaysian women. To observe any adverse effect occurrence with the consumption of the product.

Official Title
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The Efficacy and Safety of Products Containing Marine Collagen Peptide and Coenzyme Q10 for Skin Rejuvenation in Malaysian Women

Conditions
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Healthy

Intervention / Treatment
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* Other: Placebo
* Other: Product containing marine collagen peptide and Coenzyme Q10.


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Malaysian citizen Women aged 35 - 45 years old Willing to participate Exclusion Criteria: Women with skin diseases or any underlying diseases. Pregnant, breastfeeding women or planned pregnancy during the study period Allergy to collagen or other ingredients that may be found in the product. Women who had any cosmetic procedures such as botox, laser and light treatment, facial surgery, and any procedures that may improve skin hydration, elasticity, wrinkles, and brightening of skin four weeks before the study. Women who took any dietary supplements, functional foods, or medicines that could have the same or similar effects as the product evaluated in this study in the past three months.

Ages Eligible for Study
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Minimum Age: 35 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Placebo<br>The placebo group will receive a product in sachet form that doesn't have marine collagen peptide and Coenzyme Q10. | Other: Placebo<br>* Product doesn't have active ingredients i.e. marine collagen peptide and Coenzyme Q10.<br>|
| Experimental: Product containing marine collagen peptide and Coenzyme Q10.<br>This group will receive the product containing marine collagen peptide from the fish origin and Coenzyme Q10 in sachet form. | Other: Product containing marine collagen peptide and Coenzyme Q10.<br>* Product containing marine collagen peptide and Coenzyme Q10.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in skin hydration from baseline and at Day 14 and Day 28 after consumption of a product. | Skin hydration will be assessed using JANUS III skin analyzer and comparison will be made with placebo group. | Baseline, Day 14 and Day 28 | 
| Changes in skin elasticity from baseline and at Day 14 and Day 28 after consumption of a product. | Skin elasticity will be assessed using JANUS III skin analyzer comparison will be made with placebo group. | Baseline, Day 14 and Day 28 | 
| Changes in skin wrinkles from baseline and at Day 14 and Day 28 after consumption of a product. | Skin wrinkles will be assessed using JANUS III skin analyzer comparison will be made with placebo group. | Baseline, Day 14 and Day 28 | 
| Changes in skin tone from baseline and at Day 14 and Day 28 after consumption of a product. | Skin hydration will be assessed using JANUS III skin analyzer comparison will be made with placebo group. | Baseline, Day 14 and Day 28 | 
| Adverse effect after consumption of product containing marine collagen peptide and coenzyme Q10. | Based on adverse effect occurrence on participants that occur during study period (28 days) | 28 Days |