Quality of Recovery of Remimazolam Versus Sevoflurane in Transurethral Bladder Resection.

Study Overview
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Brief Summary
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This study was designated to investigate the quality of recovery after transurethral bladder resection. Because, patients undergoing transurethral bladder resection are mostly old age, and because of catheter-related bladder discomfort are common after transurethral bladder resection, study on the quality of recovery after transurethral bladder resection seems to be meaningful. In general, sevoflurane is commonly used as an anesthetic agent for general anesthesia of transurethral bladder resection. The purpose of this study is to investigate whether remimazolam is not inferior to sevoflurnane in terms of quality of recovery after transurethral bladder resection.

Official Title
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Comparison of Postoperative Recovery Quality Between Sevoflurane and Remimazolam for General Anesthesia for Transurethral Resection of Bladder Tumor

Conditions
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Quality of Recovery

Intervention / Treatment
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* Drug: Sevoflurane
* Drug: Remimazolam


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: adult patients aged from 19 years Americaln Society of Anesthesiologist's class I, II, and III scheduled to undergo elective transurethral bladder resection under general anesthesia Exclusion Criteria: refuse to participate in the study cannot read, or sign the consent form (e.g., iliterate, foreigner, eye disease) history of allergy to benzodiazepines decreased liver, kidney, or heart function pregnant women or breastfeeding patients history of drug or alcohol abuse obesity (body mass index > 30kg/m2)

Ages Eligible for Study
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Minimum Age: 19 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Sevoflurane<br>General anesthesia using sevoflurane | Drug: Sevoflurane<br>* Sevoflurane is chosen as an anesthetic agent for general anesthesia. General anesthesia for the patients in this group will be induced with propofol (1-1.5 mg/kg), and will be maintained with sevoflurane to keep patient state index of 25-50.<br>|
| Experimental: Remimazolam<br>General anesthesia using remimazolam | Drug: Remimazolam<br>* Remimazolam is chosen as an anesthetic agent for general anesthesia. General anesthesia for the patients in this group will be induced with remimazolam, and will be maintained with remimazolam to keep patient state index of 25-50.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quality of recovery -15 score at postoperative day 1 | Quality of recovery-15 questionnaire, which consists 15 questions. The score ranges from 0 to 150. The higher the score, the better the quality of recovery. | postoperative day 1 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Catheter related bladder discomfort | Catheter related bladder discomfort is assessed as none, mild, moderate and severe. | 5 minutes, and 1 hour after post-anesthesia circuit unit arrival. |