The Predictive Value of Dynamic Changes of CD4+T Lymphocytes in Primary Nephrotic Syndrome With Infection

Study Overview
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Brief Summary
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The goal of this observational study is to test whether the dynamic changes of CD4+T lymphocytes can predict infections in patients with primary nephrotic syndrome . The main questions it aims to answer are: whether the dynamic changes of CD4+T lymphocytes can predict infections in patients with primary nephrotic syndrome effect of different immunosuppressive therapy on the number and function of T lymphocyte subsets in patients with primary nephrotic syndrome Participants will be divided into infection group and non-infection group according to whether they are infected

Official Title
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The Predictive Value of Dynamic Changes of CD4+T Lymphocytes in Primary Nephrotic Syndrome With Infection

Conditions
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Nephrotic Syndrome, Infections, Lymphocyte

Intervention / Treatment
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* Other: The study is an observational study without intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age ≥ 14 years and<75 years. It meets the diagnostic criteria of primary nephrotic syndrome, i.e. a. A large amount of proteinuria (24h urine protein quantity > 3.5g/d); b. Hypoalbuminemia (liver function: albumin<30g/L); c. Edema; d. The blood lipid is elevated. Among them, item a and b are necessary conditions for diagnosis. Nephrocentesis pathology indicates the pathological type of nephrotic syndrome (minimal change glomerulonephritis, membranous nephropathy, focal segmental glomerulonephritis, membranous proliferative glomerulonephritis, mesangial proliferative glomerulonephritis). Glucocorticoids or corticosteroids combined with immunosuppressants should be used clinically. Exclusion Criteria: Secondary nephrotic syndrome, such as secondary to systemic lupus erythematosus, hepatitis B, hepatitis C, tumor, organic solvent , heavy metal poisoning, etc. Patients with tumor and chronic infectious diseases, such as HIV infection, cardiac insufficiency, acute hepatitis, transaminase increase more than twice the normal value, deep vein thrombosis. The subjects were pregnant and lactating women. Patients with serious primary diseases such as heart, brain, liver and hematopoietic system. Those who can not cooperate, such as the mentally ill. It is known that it is allergic to or has contraindications to any component in glucocorticoid, FK506, MMF and CTX. Serum creatinine (SCR) > 265.2 μ mol/L（3mg/dl）。

Ages Eligible for Study
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Minimum Age: 14 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| infection group<br> | Other: The study is an observational study without intervention<br>* The study is an observational study without intervention<br>|
| non-infection group<br> | Other: The study is an observational study without intervention<br>* The study is an observational study without intervention<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Dynamic changes of CD4+T cells | Whether the change of CD4+T lymphocytes count can predict infections in patients with primary nephrotic syndrome | 3 years after the project starts |