Peripherally Inserted Versus Centrally Inserted Central Venous Catheters in the Neurological Intensive Care

Study Overview
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Brief Summary
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The investigators aim to compare the complications between centrally and peripherally inserted central venous catheters in neurological intensive care unit patients. The study hypothesis is that peripherally inserted catheters will have more cumulative complications due to venous thrombosis.

Official Title
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A Phase III Study of Peripherally Inserted Versus Centrally Inserted Central Venous Catheters in the Neurological Intensive Care Unit

Conditions
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Venous Thrombosis

Intervention / Treatment
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* Procedure: Central venous catheter
* Procedure: Central venous catheter


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: all patients age > 18, admitted to the neurological ICU who are require a de novo central venous catheter as standard of care and in which a double lumen 5f PICC or CICVC (triple lumen, 7f) are acceptable for the indication. the patients must be expected to survive and need a central venous catheter for at least 7 days. Exclusion Criteria: prisoner age < 18 expected to die or have care withdrawn prior to ICU day 7 requiring an emergent central venous catheter suspected bacteremia recent central venous catheter within the last 30 days patients who are not a candidate for bedside placement of either a CICVC or PICC line patients with renal insufficiency with creatinine level greater than 3.0 mg/dL (265.2 m mol/L) or who were undergoing hemodialysis patients requiring a central venous catheter for prolonged antibiotic therapy\ patient who the treating clinician feels clearly needs one particular type of catheter over the other

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: PICC line (Peripherally)<br>placement of a picc line | Procedure: Central venous catheter<br>* Placement of a peripherally inserted central venous catheter<br>|
| Active Comparator: CICVC (central insertion)<br>placement of a centrally inserted central venous catheter | Procedure: Central venous catheter<br>* Placement of a centrally inserted central venous catheter<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The composite of death or catheter related large vein thrombosis |  | 15 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cumulative catheter related complications until discharge |  | 30 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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catheter related large vein thrombosis, upper extremity deep venous thrombosis, central venous catheters, upper extremity catheter related large vein thrombosis