Perioperative Transfusion Related Outcome

Study Overview
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Brief Summary
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A secondary analysis of the Turkish National Perioperative Transfusion Study (TULIP TS) database will be performed.

Detailed Description
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The Turkish National Perioperative Transfusion Study (TULIP TS) was conducted by The Turkish Society of Anesthesiologists' Multicentre Clinical Trials Network. TULIP TS included 6481 patients undergoing major elective surgery, from 61 study sites across the country. Transfusion practices of clinicians working at diverse surgical fields; differences between current transfusion practices and patient blood management strategies; the areas for improvement and the obstacles that could prevent change were evaluated and identified. Data relevant to perioperative transfusion rates of red blood cells, fresh frozen plasma and platelets, the indications for transfusion and postoperative adverse outcomes including 1 month all cause mortality was obtained. The TULIP TS group aims to collect further data concerning 1 year all cause mortality of the same patient population and to evaluate adverse outcomes in transfused and non transfused patients.

Official Title
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Effect of Perioperative Transfusion on Early and Late Outcome After Major Elective Surgery

Conditions
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Blood Transfusion

Intervention / Treatment
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* Other: Blood transfusion
* Other: Control


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: • Patients undergoing major elective surgery Exclusion Criteria: • Trauma patients, emergency surgery

Ages Eligible for Study
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Minimum Age: 1 Day
Maximum Age: 100 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Transfused<br>Patients who received blood transfusion in the perioperative period | Other: Blood transfusion<br>* Patients who received blood transfusion in the perioperative period<br>|
| Non transfused<br>Patients who did not receive blood transfusion in the perioperative period | Other: Control<br>* Patients who did not receive blood transfusion in the perioperative period<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 1 year all cause mortality | Number of participants died: all cause mortality | postoperative 366th day | 
| Acute kidney injury | Number of participants with acute kidney injury | postoperative 30th day | 
| Acute respiratory failure | Number of participants with acute respiratory failure | postoperative 30th day | 
| Thromboembolic event | Number of participants with a thromboembolic event | postoperative 30th day | 
| Ischemic event | Number of participants with an ischemic event | postoperative 30th day | 
| Infection | Number of participants with infection | postoperative 30th day | 
| Myocardial infarction | Number of participants with myocardial infarction | postoperative 30th day | 
| Adverse cardiac event | Number of participants with an adverse cardiac event | postoperative 30th day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Surgery, Perioperative, Transfusion, Mortality