LODS Role in Predicting 30-day Mortality Outcome in ICU

Study Overview
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Brief Summary
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LODS score for deceased ICU patients within 30 days is higher than survived ICU patients

Official Title
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Logistic Organ Dysfunction System Role in Predicting 30-day Mortality Outcome in Intensive Care Unit of dr. Cipto Mangunkusumo General Hospital Patients

Conditions
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Mortality

Intervention / Treatment
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* Other: Logistic Organ Dysfunction System Score


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: adult patient (age 18 years and above) admitted to ICU Exclusion Criteria: patients admitted to ICU due to burn injury, coronary artery disease, post cardiac surgery patients with incomplete required information for LODS score patients deceased or discharged less than 24 hours of admission

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Mortality outcome<br> | Other: Logistic Organ Dysfunction System Score<br>* Variables of logistic organ dysfunction system score, including: GCS; heart rate; systolic BP; blood urea; serum creatinine; urine output; leucocyte count; platelet count; PaO2/FiO2; serum bilirubin; prothrombin time.<br>* Other names: LODS;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| LODS score discrimination ability | LODS score ability to discriminate patient outcomes based on variables of logistic organ dysfunction system scores: GCS; heart rate; systolic BP; blood urea; serum creatinine; urine output; leucocyte count; platelet count; PaO2/FiO2; serum bilirubin; prothrombin time. | 30 days from admission | 
| LODS score calibration | LODS score ability to predict patient outcomes based on variables of logistic organ dysfunction system scores: GCS; heart rate; systolic BP; blood urea; serum creatinine; urine output; leucocyte count; platelet count; PaO2/FiO2; serum bilirubin; prothrombin time. | 30 days from admission | 
| Correlation between LODS score variables with patient outcome | Correlation between patient outcomes with each LODS score variables: GCS; heart rate; systolic BP; blood urea; serum creatinine; urine output; leucocyte count; platelet count; PaO2/FiO2; serum bilirubin; prothrombin time. | 30 days from admission | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patient outcome | Patient outcome within 30 days of admission to intensive care unit (ICU): deceased or survived | 30 days from admission | 
| LODS neurologic variable score: Glasgow Coma Scale (GCS) | The score for GCS variable cutoff: 0 point for 14-15; 1 point for 9-13; 3 points for 6-8; 5 points for 3-5. | Day 1 | 
| LODS cardiovascular variable score: Heart rate (HR) and/or systolic blood pressure (SBP) | The score for HR (in bpm) and/or SBP (in mmHg) variable cutoff: 0 point for HR 30-139 and SBP 90-239; 1 point for SBP 70-89 or 240-269 or HR >=140; 3 points for SBP 40-69 or >=270; 5 points for HR <30 or SBP <40. | Day 1 | 
| LODS renal variable score: serum urea nitrogen (BUN) and/or creatinine and/or urine output (UO) | The score for BUN (in mg/dL) and/or creatinine (in mg/dL) and/or UO (in litres/day) variable cutoff: 0 point for BUN <17 AND creatinine <1.20 AND UO 0.75-9.99; 1 point for BUN 17-<28 OR creatinine 1.20-1.59; 3 points for BUN 28-<56 AND creatinine <1.60 AND UO 0.5-0.74 or >=10; 5 points for BUN >=56 OR UO 0.5. | Day 1 | 
| LODS pulmonary variable score: Partial oxygen pressure (PaO2)/Fraction of inspired oxygen (FiO2) on Mechanical Ventilation (MV) or Continuous Positive Airway Pressure (CPAP) | The score for PaO2/FiO2 (in mmHg/%) variable cutoff: 0 point for no ventilation and no CPAP; 1 point for >=150; 3 points for <150. | Day 1 | 
| LODS hematologic variable score: white blood cell (WBC) count and/or platelet count | The score for WBC (in x10^3/L) and/or platelet count in (x10^3/L) variable cutoff: 0 point for WBC 2.5-49.9 and platelet >=50; 1 point for WBC 1.0-2.4 or >=50.0 OR platelet <50; 3 points for WBC <1.0 | Day 1 | 
| LODS hepatic function variable score: Serum Bilirubin and/or Prothrombin time (PT) | The score for serum bilirubin (in mg/dL) and/or PT (in % of standard) variable cutoff: 0 point for bilirubin <2.0 and PT >=25; 1 point for bilirubin >=2.0 OR PT<25% or >3. | Day 1 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Intensive care unit, Logistic Organ Dysfunction System, 30-day Mortality, Sepsis, Mortality prediction