Short-term Health Benefits of Using Fresh Air Filtration System in Classroom

Study Overview
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Brief Summary
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A randomized crossover trial will be conducted in 90 primary school children in 3 classrooms in Shanghai, China. The effects of fresh air ventilation/filtration system, fresh air ventilation system with no filtration and natual ventilation will be compared on the effects of reducing indoor PM2.5 and chilhood health. Biological samples of children are going to be collected to investigate the associations between indoor air pollution and biomarkes of certain health effects.

Detailed Description
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A randomized crossover trial among 90 primary students in 3 classrooms in Shanghai, China will be performed. Three arms are going to be 1) fresh air filtration system, 2) fresh air system with no filtration and 3) natural ventilation. Each arm is going to be in use for five continuous weekdays followed by one week of wash-out. After one-week of wash out, a cross over change between 3 arms is going to be taked. Then the 2nd week of intervention is performed followed by the 2nd wash-out week. The same cross-over change between 3 arms is going to be repeated again until each classroom will be applied by all three arms of ventilation. A total of 5 weeks is required for the project. Children's biological samples including saliva, urine and skin samples will be collected as well as exhaled NO. A questionnaire on children's perception on air quality will be assessed as well.

Official Title
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Effects of Fresh Air Filtration System on Indoor Air Quality and Children's Health in Shanghai Schools

Conditions
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Airway Morbidity, Cognitive and Attention Disorders and Disturbances, Oxidative Stress

Intervention / Treatment
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* Device: Fresh air system with filtration


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All invited primary school children in Grade 5 in an artibrarily selected school Exclusion Criteria: Current airway symptoms (cough, airway infection, asthma et al.) Acute infectious diseases

Ages Eligible for Study
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Minimum Age: 10 Years
Maximum Age: 13 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Fresh air system with filtration<br>A fresh air ventilation system combined with PM2.5 filtration is applied in one primary school classroom. | Device: Fresh air system with filtration<br>* Using fresh air ventilation combined with PM2.5 filtration system to reduce the indoor PM2.5 concentration in primarty school classrooms<br>* Other names: mechanical ventilation and filtration system;|
| Placebo Comparator: Fresh air system with no filtration<br>A fresh air ventilation system with no PM2.5 filtration is applied in a parallel classroom. | Device: Fresh air system with filtration<br>* Using fresh air ventilation combined with PM2.5 filtration system to reduce the indoor PM2.5 concentration in primarty school classrooms<br>* Other names: mechanical ventilation and filtration system;|
| No Intervention: Natural ventilation<br>Natural ventilation system was applied in the 3rd classroom as normal. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Exhaled nitric oxide | Airway inflammation biomarker | within 2 hours of the end of intervention in each week | 
| Oxidative stress biomarkers | The level of lysozyme, cortisone and SIgA will be assessed in saliva and other oxidative biomarkers in the urine samples in children. | within 2 hours of the end of intervention in each week | 
| Sick building symdrom | Answering questionnaire on sick biulding symdrom | within 2 hours of the end of intervention in each week | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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exhaled nitric oxide, Sick building syndrome, indoor air