Clinical Usefulness of Virtual Ablation Guided Catheter Ablation of Atrial Fibrillation: Virtual Rotor Mapping and Catheter Ablation

Study Overview
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Brief Summary
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Radiofrequency catheter ablation is effective in the treatment of patients with paroxysmal atrial fibrillation. In order to reduce the recurrence rate after catheter ablation, the investigators propose to apply 'virtual' ablation on patient-specific atria by simulating 3D atrial computer model. The investigators will conduct virtual rotor mapping in the patient specific atrial model. Then, the investigators will compare the clinical outcome of conventional circumferential pulmonary vein isolation and additional rotor ablation guided by virtual rotor mapping.

Official Title
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Clinical Usefulness of Virtual Ablation Guided Catheter Ablation of Atrial Fibrillation: Virtual Rotor Mapping and Catheter Ablation

Conditions
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Paroxysmal Atrial Fibrillation

Intervention / Treatment
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* Procedure: physician's personal experience
* Procedure: Virtual rotor mapping


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: AF patient age 19 80 Diagnosis of AF patients who performed catheter ablation of atrial fibrillation due to uncontrolled pulse rate by anti-arrhythmic drug therapy. Exclusion Criteria: AF patients who have severe heart deformations or vascular disease. The patient who have renal disease of eGFR<30mL/min The patients who had been performed catheter ablation of atrial ablation and MAZE. The patients who missed out to recording of 3D CT, echo and electrocardiography. the patient have experienced major hemorrhagic complication The patient have experienced ischemic cerebral infarction more 2 times The patient who have risk of ischemic cerebral infarction (CHA2DS2-VASc Score >5)

Ages Eligible for Study
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Minimum Age: 19 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: conventional group<br>Group operating the atrial fibrillation by physician's personal experience, not by virtual simulation. | Procedure: physician's personal experience<br>* physician's personal experience<br>|
| Experimental: 3D atrial computer model<br>Group choosing choose the best effective rotor mapping by simulating 3D atrial computer model which consider patinet's heart size and shape. | Procedure: Virtual rotor mapping<br>* Virtual rotor mapping<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Recurrence rate of atrial fibrillation of 18 months after procedure within 18 months |  | 18 months | 
| Rate of mortality, incidence of cerebral infarction and hospitalization after procedure |  | 24 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Major complication related procedure : Complication of hemorrhagic and embolic |  | 24 months | 
| Pericardial effusion required treatment, 4g/dL reduced level of Hb, Hemorrhage required blood transfusion and Cerebral infarction related procedure |  | 24 months | 
| Procedure time and Radiofrequency ablation time |  | 24 months |