The Relationship Between Lipid Peroxidation Products From Traumatic Brain Injury and Secondary Coagulation Disorders

Study Overview
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Brief Summary
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The purpose of this study is to observe the relationship between the level of lipid peroxidation products in serum of patients with traumatic brain injury and secondary coagulation disorders.

Detailed Description
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Uncontrolled hemorrhage after trauma is the leading cause of death. The mechanism of secondary coagulation dysfunction after trauma is special and complex, which has not been fully explained, leading to limited treatment and prevention methods. Coagulation disorders caused by traumatic brain injury is a systemic manifestation of local injury, which can activate platelets and promote platelet aggregation, activate thrombin, and promote the production of fibrin, leading to the formation of thrombosis. However, in non-injured areas, pro-coagulant molecules from damaged brain tissue reach the body through the broken blood-brain barrier, and also activate platelets and thrombin, promoting the formation of blood clots. Lipid peroxidation products are closely related to the occurrence of coagulation dysfunction. The effects lipid peroxidation products on platelets, thrombin and anticoagulant pathways may be a novel mechanism of secondary coagulation dysfunction in traumatic brain injury.

Official Title
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The Relationship Between Lipid Peroxidation Products From Traumatic Brain Injury and Secondary Coagulation Disorders

Conditions
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Traumatic Brain Injury, Coagulation Disorder

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: The interval between injury and admission is less than 24 hours Age>18yrs and age<80yrs Non-head abbreviated injury score < 3 Did not undertake treatment before enrollment Informed consent to participate in the study Exclusion Criteria: Take anticoagulants or antiplatelet drugs Smoking history Hemorrhagic or ischemic cerebrovascular disease occurred within six months Other systemic diseases: uremia, cirrhosis, malignant tumor, etc Patients with severe mental illness who are unable to communicate when diagnosed Patients who refused follow-up

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The level of lipid peroxidation products in subjects' serum | the level of high and low | within 24 hours of trauma | 
| Coagulation Disorders | aPTT>40s or INR>1.4 or <100 platelets per L | within 24 hours of trauma | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The 24-hour and 3-month Glasgow outcome score (GOS) |  | from onset to three months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Traumatic Brain Injury, Coagulation Disorder, Lipid Peroxidation