Doppler-based Renal Resistive Index in Assessing Renal Dysfunction Reversibility in ICU Patients

Study Overview
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Brief Summary
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Acute kidney injury (AKI) is common in intensive care unit (ICU) patients and remains associated with a dismal prognosis. The diagnosis of AKI relies on functional criteria (oliguria and serum creatinine elevation), which carry several important limitations. Additionally, the investigators lack biomarker that may predict short term renal prognosis. Doppler-based renal resistive index (RI) measurement is a rapid and noninvasive investigative tool that may hold promise for early AKI detection in ICU patients or in differentiating transient from persistent AKI in selected critically ill patients. Although several studies have suggested adequate performance in predicting short-term reversibility of AKI, most of these studies were performed in limited patient samples. Additionally, a recent study has identified discrepant results regarding its diagnostic performance. The main objective of this large prospective multicentre study is to assess diagnostic performance of Doppler-based renal resistive index in diagnosing persistent AKI in critically ill patients requiring mechanical ventilation.

Official Title
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Doppler-based Renal Resistive Index in Assessing Renal Dysfunction Reversibility in ICU Patients

Conditions
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Acute Kidney Injury

Intervention / Treatment
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* Other: Doppler-based renal
* Biological: blood sample and urine sample


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Sinus rhythm Use of conventional mechanical ventilation Exclusion Criteria: Refusal: patient, family or trusted person to participate in the study Renal artery stenosis known Pregnant Severe Chronic Renal Failure (clearance < 30 ml.min-1)

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: ICU patients requiring mechanical ventilation<br> | Other: Doppler-based renal<br>* Doppler-based renal : day 0 and day 3<br>Biological: blood sample and urine sample<br>* blood sample and urine sample : day 0 and day 3<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Doppler-based renal resistive index | Doppler-based renal resistive index in diagnosing persistent AKI in critically ill patients requiring mechanical ventilation | Day 0 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Doppler-based renal resistive index |  | Day 3 | 
| Dosages NGAL plasmatique, NGAL urinaire, IGFBP-7, TIMP-2 |  | Day 0 | 
| Dosages NGAL plasmatique, NGAL urinaire, IGFBP-7, TIMP-2 |  | Day 3 | 
| usual urinary indices (Fractional excretion of urea, fractional excretion of sodium, ratio U / P urea ratio U / P creatinine) |  | Day 0 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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ICU patients, Doppler-based renal