Functional Lipids and Appetite Regulation

Study Overview
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Brief Summary
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To evaluate the short-term effects of structured lipids on appetite regulation.

Detailed Description
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Background Obesity is a major health problem worldwide, and it is a risk factor for several chronic disorders. Even small changes in energy intake, leading to a positive balance may lead to weight gain over time. Thus, slight modifications in food intake, such as the inclusion of foods that effect energy balance, may prevent weight gain and even facilitate weight loss. Replacing dietary fat with low-calorie fat (LCF), such as modified triglycerides with medium and long chained PUFA.may be an efficient way to reduce body fat. Bray et al. (2002) has shown a sustained weight loss of  6 kg over a 9 month period where one-third of a fat-reduced diet (25% fat) was replaced by olestra. This weight loss can not solely be explained by the decreased caloric content of olestra. Thus, inhibition of appetite leading to lower food intake, may be a potential mechanism of the observed weight loss. A reduced absorption of LCF leaves undigested fatty acids in the middle and lower intestine, which may generate increased feelings of satiety and decrease caloric intake due to regulating peptides and hormones such (CCK, GLP-1, etc.). In addition, intraduodenal fatty acids may also promote distension of the stomach and distension of the intestine, which are well-known gastrointestinal signals controlling mechanisms for food intake. Taken together, in addition to the acute reduction in caloric intake, LCF may encourage a gastrointestinal hormone response promoting beneficial effects on appetite regulation and energy balance. Aims To evaluate the short-term effects of LCF on Primary: Appetite sensations after a meal (VAS) Postprandiel secretion of appetite regulating hormones Ad libitum caloric intake 4,5-h subsequent to a fixed meal Secondary: • Palatability of the test meal

Official Title
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The Effect of Functional Lipids on Appetite Regulation in Man

Conditions
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Obesity

Intervention / Treatment
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* Behavioral: SALATRIM


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: healthy males Normal weigh, e.i. BMI between 18,5-25 kg/m2 age 18-40 years Exclusion Criteria: donation of blood 3 monhts prior or during the study gastrointestinal disorders, diabetes, hypertension, hyperlipidemia, chronic infectious disease smoking consumption of more than 21 alcoholic drinks/week elite athletes on mediation diet supplements

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: SALATRIM|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Appetite |  |  | 
| energy intake |  |  | 
| Hormones |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Palability |  |  | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Appetite regulation, Hormones, Energy intake