OCTA and Retinal Angiomatous Proliferation

Study Overview
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Brief Summary
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To investigate, using optical coherence tomography angiography, the retinal vascular features in patients affected by RAP.

Detailed Description
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Retinal vascular anomalous complex represents a distinct form of neovascularization in patients with age-related macular degeneration. The study investigated the changes in retinal vascular network using optical coherence tomography angiography, a novel and non invasive diagnostic technique that allows to better understand the pathophysiologic mechanism of this neovascularization.

Official Title
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The Role of Quantitative Deep Capillary Plexus in the Pathogenesis of Retinal Angiomatous Proliferation: an Optical Coherence Tomography Angiography Study.

Conditions
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Age Related Macular Degeneration

Intervention / Treatment
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* Diagnostic Test: optical coherence tomography angiography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age older than 65 years diagnosis of retinal angiomatous proliferation and reticular pseudodrusen absence of previous ocular surgery, congenital eye disease, high myopia (>6 dioptres), actual or previous diagnosis of glaucoma, optic disc anomaly, macular or vitreoretinal diseases. absence of significant lens opacities, low-quality OCT-A images. Exclusion Criteria: age older than 80 years absence of diagnosis of retinal angiomatous proliferation and reticular pseudodrusen presence of previous ocular surgery, congenital eye disease, high myopia (>6 dioptres), actual or previous diagnosis of glaucoma, optic disc anomaly, macular or vitreoretinal diseases. presence of significant lens opacities, low-quality OCT-A images.

Ages Eligible for Study
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Minimum Age: 65 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with RAP<br>Patients with previous diagnosis of retinal angiomatous proliferation | Diagnostic Test: optical coherence tomography angiography<br>* optical coherence tomography aniography is a non-invasive, fast, diagnostic imaging technique that evaluates the retinal vascular network<br>|
| Patients with reticular pseudodrusen<br>Patients with previous diagnosis of reticular pseudodrusen | Diagnostic Test: optical coherence tomography angiography<br>* optical coherence tomography aniography is a non-invasive, fast, diagnostic imaging technique that evaluates the retinal vascular network<br>|
| Control group<br>Healthy eyes without actual and previous ocular diseases | Diagnostic Test: optical coherence tomography angiography<br>* optical coherence tomography aniography is a non-invasive, fast, diagnostic imaging technique that evaluates the retinal vascular network<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The measurements of retinal vascular network in patients with age-related macular degeneration, using optical coherence tomography angiography, compared to controls | The parameters analyzed by optical coherence tomography angiography were: vessel density of superficial capillary plexus and deep capillary plexus | 15 months |