Transcutaneous Electrical Acupoint Stimulation(TEAS) for Hepatic and Renal Dysfunction After Pneumoperitoneum

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to compare the effect of TEAS pretreatment and treatment on hepatic and renal dysfunction induced by pneumoperitoneum in patients undergoing laparoscopic surgeries.

Detailed Description
-----------------
Patients were randomly assigned to three groups, control group and two intervention groups, receiving TEAS before and after general anesthesia induction respectively. TEAS was given through electrodes attached to acupoints. The time for TEAS was 30min. Venous blood samples were collected before and 20min after pneumoperitoneum. Hepatic and renal function index including AST, ALT, ALP, BUN, Cr were measured.

Official Title
-----------------
Effect of Transcutaneous Electrical Acupoint Stimulation(TEAS) on the Hepatic and Renal Function Impaired by Pneumoperitoneum: a Prospective, Randomized Controlled Trial

Conditions
-----------------
Hepatic Dysfunction Transient, Renal Function Disorder

Intervention / Treatment
-----------------
* Other: TEAS pretreatment
* Other: TEAS treatment


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age>18yrs,<60yrs； ASA 1-2； Scheduled for laparoscopic surgery under general anesthesia； Informed consented Exclusion Criteria: Patients with hepatic or renal dysfunction； Patients with severe hypertension or cardiac dysfunction； Patients with severe pulmonary disease； Patients with hemoglobin<100g/L

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Control<br>Patients were given no TEAS | |
| Experimental: TEAS Pretreatment<br>Patients were given 30min of TEAS before pneumoperitoneum | Other: TEAS pretreatment<br>* Electric stimulation was given through electrode attached to specific acupoints for 30mins before anesthesia induction<br>|
| Experimental: TEAS Treatment<br>Patients were given 30min of TEAS during pneumoperitoneum | Other: TEAS treatment<br>* Transcutaneous Electrical Acupoint Stimulation was given to the patient at the same time of the start of anesthesia induction for 30mins<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of renal or hepatic dysfunction | percentage of patients with renal or hepatic dysfunction | 20min after pneumoperitoneum | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of hepatic function | the increase of hepatic ALT and AST after pneumoperitoneum | 20min after pneumoperitoneum | 
| Change of renal function | Change of BUN and Cr after pneumoperitoneum | 20min after pneumoperitoneum | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
hepatic dysfunction, renal dysfunction, pneumoperitoneum, Transcutaneous electric stimulation