linjc16/ctgov huggingface dataset:
The Treatment and Intra-operative Imaging of Scaphoid Fracture Reduction and Fixation

Study Overview
=================
Brief Summary
-----------------
Scaphoid fractures are the most common carpal bone fractures, and second most common wrist fractures (second to distal radius fractures). Lack of proper immobilization or displacement of these fractures commonly results in fracture nonunion or malunion followed by the development of wrist post-traumatic osteoarthritis. In addition, proper reduction and fixation of these fractures are challenging to the most experienced hand surgeons. The investigators are going to follow-up the patients population suffering from Scaphoid fractures(nonunion included) for one year. The investigators will evaluate this follow up results in two ways: Intra-operative imaging of scaphoid fracture fixation - feasibility evaluation. Treatment of scaphoid fracture non-union.

Conditions
-----------------
Scaphoid Fractures

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Ages of 18 and 60 during the study period; Scaphoid fractures to be operatively reduced and fixated, including fracture non-unions; Signed informed consent. Exclusion Criteria: Non-displaced fractures of the scaphoid. Soldiers in active military service. pregnant women

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Intra-operative imaging of scaphoid fracture fixation - feasibility evaluation |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Fracture in the Scaphoid fractures
Comparison of a New Masterful Preparation to Kligman's Trio in the Treatment of Melasma

Study Overview
=================
Brief Summary
-----------------
Kligman's trio remains the gold standard treatment for melasma. It contain hydroquinone which is an effective anti-melanogenic compound but that has poor tolerance and numerous side-effects. Thiamidol has been proven to be at least as effective as hydroquinone and has a very good safety profile. The objective of this study is to compare the Kligman's trio to the same preparation in which hydroquinone is replaced by thiamidol.

Official Title
-----------------
Comparison of a New Masterful Preparation to Kligman's Trio in the Treatment of Melasma: a Double Blind Prospective Randomzed Study

Conditions
-----------------
Melanosis

Intervention / Treatment
-----------------
* Drug: New trio de Kligman
* Drug: Trio Kligman


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: SIGNED WRITTEN CONSENT 1) Melasma clinically diagnosed Exclusion Criteria: Pregnant woman Other pigmentary disorder affecting the face Use of systemic or topical steroids or retinoids, use of topical depigmenting agents or depigmenting procedure in the month before the inclusion

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: New traitement<br>Thiamidol, retinoid, topical steroid preparation | Drug: New trio de Kligman<br>* Once daily application in addition to the same sunscreen<br>|
| Other: Kligman's trio<br>Application once a day for 12 weeks | Drug: Trio Kligman<br>* Once daily application in addition to the same sunscreen<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The melasma's type | Clinical score MASI | at 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the Quality of life of patient | descriptive name of scale : meslascol | at 12 weeks |
An Algorithm Driven Sepsis Prediction Biomarker

Study Overview
=================
Brief Summary
-----------------
A sepsis early warning predictive algorithm, InSight, has been developed and validated on a large, diverse patient cohort. In this prospective study, the ability of InSight to predict severe sepsis patients is investigated. Specifically, InSight is compared with a well established severe sepsis detector in the UCSF electronic health record (EHR).

Official Title
-----------------
A Randomized Controlled Clinical Trial of an Algorithm Driven Sepsis Prediction Biomarker

Conditions
-----------------
Sepsis, Septic Shock, Severe Sepsis

Intervention / Treatment
-----------------
* Other: Severe Sepsis Prediction
* Other: Severe Sepsis Detection


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All adult patients admitted to the participating units will be eligible. Exclusion Criteria: All patients younger than 18 years of age will be excluded.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Screening
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: With InSight<br>Healthcare provider receives an alert from InSight for patients trending towards severe sepsis. Healthcare provider also receives information from the severe sepsis detector in the UCSF electronic health record. | Other: Severe Sepsis Prediction<br>* Upon receiving an InSight alert, healthcare provider follows standard practices in assessing possible (severe) sepsis and intervening accordingly.<br>Other: Severe Sepsis Detection<br>* Upon receiving information from the severe sepsis detector in the UCSF electronic health record, healthcare provider follows standard practices in assessing possible (severe) sepsis and intervening accordingly.<br>|
| Active Comparator: Without InSight<br>Healthcare provider does not receive any alerts from InSight. Healthcare provider receives information from the severe sepsis detector in the UCSF electronic health record. | Other: Severe Sepsis Detection<br>* Upon receiving information from the severe sepsis detector in the UCSF electronic health record, healthcare provider follows standard practices in assessing possible (severe) sepsis and intervening accordingly.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hospital length of stay |  | Through study completion, an average of 45 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| In-hospital mortality |  | Through study completion, an average of 45 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
InSight, Dascena
A Randomized Controlled Trial of Using Video Images in Dementia

Study Overview
=================
Brief Summary
-----------------
BACKGROUND: Advance care planning (ACP) is the process in which patients plan for future medical care under circumstances of impaired decision-making. Video is an underutilized medium that can assist clinicians in discussions of future health states, such as the state of advanced dementia. Video may enable patients to visualize the future by concisely providing complex information vital for ACP. This study will examine whether the use of video could facilitate a more comprehensive understanding of advanced dementia and inform clinician-patient discussions about the level of care a patient would want in the event of advanced dementia. RESEARCH PLAN: We propose to conduct a randomized trial studying ACP for 200 elderly subjects using a video depiction of a patient with dementia compared to the traditional verbal narrative. Specific aims 1 and 2 assess the effect of a video of advanced dementia on the clinical decision making of elderly subjects compared to the traditional verbal narrative.

Detailed Description
-----------------
Outcome measures were what subjects wanted if they had advanced dementia.

Official Title
-----------------
A Randomized Controlled Trial of Using Video Images in Dementia

Conditions
-----------------
Dementia

Intervention / Treatment
-----------------
* Other: video


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Over 64 Exclusion Criteria: Can't speak English

Ages Eligible for Study
-----------------
Minimum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: 1<br>verbal | |
| Experimental: 2<br>video | Other: video<br>* video of dementia<br>* Other names: video decision aid;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| preferences |  | at time of interview | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
dementia
The Effect of Silicone Hydrogel Contact Lenses on Conjunctival Flora

Study Overview
=================
Brief Summary
-----------------
The primary purpose of this study is to investigate the effect of silicone hydrogel contact lenses on conjunctival flora over a period of 6 months of daily wear. A secondary aim is to compare the levels of microbial contamination of silicone hydrogel lenses after daily wear.

Conditions
-----------------
Myopia

Intervention / Treatment
-----------------
* Device: Silicone hydrogel contact lens


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Is correctable to at least 6/9 distance visual acuity in each eye with spherical contact lenses. Is a current full time soft contact lens wearer. Has no clinically significant anterior eye findings. Has no other active ocular disease Exclusion Criteria: Has any systemic disease that might interfere with contact lens wear Is using any systemic or topical medications that will affect ocular health. Has any pre-existing ocular irritation that would preclude contact lens fitting. Has any ocular pathology or severe insufficiency of lacrimal secretion (dry eyes) that would affect the wearing of contact lenses. Has undergone corneal refractive surgery. Is pregnant, lactating or planning a pregnancy. Is participating in a concurrent clinical trial. Has a latex sensitivity.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: Silicone hydrogel contact lens|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
The Effect of Embryo Culture Under a Continuous CO2 Setting Versus a Sequential CO2 Setting

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine if embryo culture under a single CO2 setting improves blastocyst formation rate.

Detailed Description
-----------------
Following enrollment, patients will undergo ovarian stimulation and oocyte retrieval per routine as previously consented to at the clinic. IVF stimulation protocol will be at the discretion of the patient's individual provider, per routine. Intracytoplasmic Sperm Injection (ICSI) will be performed and embryos will be cultured to the blastocyst stage per routine. There are no changes to the embryology care itself, the only difference within the study is the CO2 level within the incubator pending the patient's randomization.

Official Title
-----------------
The Effect of Embryo Culture Under a Continuous CO2 Setting Versus a Sequential CO2 Setting

Conditions
-----------------
Infertility

Intervention / Treatment
-----------------
* Other: Continuous CO2 Level


Participation Criteria
=================
Eligibility Criteria
-----------------
Major Inclusion Criteria for participants: 1. Patients undergoing IVF stimulation cycle with plan for subsequent FET Major Exclusion Criteria for participants: All patients who do not voluntarily give their written consent for participation Male partner with <100,000 total motile spermatozoa per ejaculate (donor sperm is acceptable) Use of surgical procedures to obtain sperm

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Continuous CO2 Level<br>embryos will remain in a single incubator set at a continuousCO2 level | Other: Continuous CO2 Level<br>* Embryos will be cultured in a single, continuous CO2 setting<br>|
| No Intervention: Sequential CO2 Level<br>Current standard of care | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| blastulation rate | the number of zygotes that reach the blastocyst stage | approximately one week |
microRNA Profiles Identification in Adeno Carcinoma Prostate Cancer

Study Overview
=================
Brief Summary
-----------------
In our study, the investigators want to find correlation between circulating miRNAs associated with prostate cancer metastases to bones and to lymph nodes separately with results of 68Ga-PSMA ligand PET (positron emission computed) imaging.

Conditions
-----------------
Prostate Carcinosarcoma

Intervention / Treatment
-----------------
* Biological: High PSA levels


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Proven Adeno-carcinoma Underwent prostatectomy and still present high PSA levels Refered to PSMA exam. Exclusion Criteria: Below 18 years old HIV/HBV (hepatitis B virus)/HCV (hepatitis C virus) positive Additional malignancy during the past five years.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| High PSA (prostate-specific antigen) levels<br> | Biological: High PSA levels<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Metastasis size and location | Location of metastasis by a report analyzing the pathological examination (PET-MR output). | 18 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| MicroRNA profile by using Nano-string technology validated by real time PCR | Validation of MicroRNA pattern by using real time PCR | 24 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
PET-MR, MicroRNA, Prostate Carcinoma
Hyperinsulinemic Normoglycemic Clamp for Pancreas and Simultaneous Pancreas/Kidney Transplant Recipients

Study Overview
=================
Brief Summary
-----------------
This study proposes a simple and safe way of lowering this complicate rate, while improving graft recovering and protecting the graft as it recovers from the transplant. The investigators hypothesize that by maintaining a tight glucose control via a glucose-insulin clamp during surgery and 72 hours post-operatively the investigators will be able to lower the complication rate by 50%.

Official Title
-----------------
Hyperinsulinemic Normoglycemic Clamp for Pancreas and Simultaneous Pancreas/Kidney Transplant Recipients

Conditions
-----------------
Postoperative Complications

Intervention / Treatment
-----------------
* Other: Hyperinsulinemic Normoglycemic Clamp


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Male or female patient over 18 years of age Patient is about to receive a pancreas or a simultaneous pancreas/kidney transplant Able to give written informed consent prior to any study specific procedure Exclusion Criteria: Multi-organ transplant other than kidney transplant No central venous access available to deliver the D20W solution

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Study Group<br>Hyperinsulinemic Normoglycemic Clamp will be started at the time of surgery (before incision) and will be continue for 3 days. | Other: Hyperinsulinemic Normoglycemic Clamp<br>* The patient receives insulin intravenous infusion at 2ml units/kg/min. Dextrose 20% (D20W ®) will be titrated to maintain blood glucose between 4 - 6 mmol/L (72 - 108 mg/dl).<br>|
| No Intervention: Control Group<br>Patients in the control group will receive standard care. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The number of post-transplants all complications up to 30 days (Clavien grading). |  | 30 days post-operative | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The number of 30 days post-transplant serious medical complication (Clavien grade 3, 4) |  | 30 days post-op | 
| The length of hospital stay (days) |  | Length of hospital stay (day 1 until discharge) | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Pancreas Transplantation, Kidney Transplantation, Organ Transplantation, Pancreas and Simultaneous Pancreas/Kidney Transplant Recipients
TEM Assisted Perineal Rectopexy in Treatment of Rectal Prolapse

Study Overview
=================
Brief Summary
-----------------
Curvilinear incision in the postanal space, through the intersphincteric plane, insertion of Proctoscope of TEM technique and dissection till sacral promontory, insertion of mesh between the rectum and sacrum, post anal repair then anal cerclage width absorbable suture.

Detailed Description
-----------------
Perineal Rectopexy is performed by an incision in the intersphincteric space followed by dissection till the sacral promontory then Proctoscope is inserted to complete the dissection .Mesh is inserted and fixed to the sacrum with laparoscopic tacker ( or can be left unfixed) then postanal repair is conducted in two layers ( levatorplasty then sphincteroplasty) and finally Ana cerclage is done with polyglactin 0 sutures

Official Title
-----------------
Trans-anal Endoscopic Microsurgery (TEM) Assisted Perineal Rectopexy With Postanal Repair and Anal Cerclage In Treatment of Rectal Prolapse (Novel Technique)

Conditions
-----------------
Rectal Prolapse

Intervention / Treatment
-----------------
* Procedure: TEM perineal rectopexy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients with complete or partial rectal prolapse Exclusion Criteria: patients unfit for surgery patients with previous surgery for rectal prolapse patients with associated anorectal pathology (e.g fistula ) patients with constipation as a predominant symptom.

Ages Eligible for Study
-----------------
Minimum Age: 14 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: TEM perineal Rectopexy<br>TEM perineal rectopexy: triple repair technique , Perineal rectopexy with a polyprolene mesh assisted by TEM technique, postanal repair to close the postanak space then finally anal cerclage to hold the rectum in place for one month. | Procedure: TEM perineal rectopexy<br>* perineal rectopexy using polyprolene mesh assisted by TEM technique and special proctoscope postanal repair in two layers to narrow the postanal space anal cerclage with absorbable sutures<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Recurrence of prolapse | Number of patients presenting with recurrent rectal prolapse within 12 months after surgery | 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Improvement of continence state | Amount of increase in continence score after surgery | 12 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
TEM, Rectopexy, rectal prolapse