FENO, Extended NO Analysis and NO/CO Diffusing Capacity in Thoracic Radiation Therapy

Study Overview
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Brief Summary
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The investigators aim to investigate the impact of thoracic radiation therapy on diffusion capacity of the lung (primary endpoint: diffusion capacity for nitric oxide, DLNO) and on exhaled nitric oxide.

Official Title
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Fractional Exhaled NO, Extended NO Analysis and NO/CO Diffusing Capacity in Patients Receiving Thoracic Radiation Therapy: a Single Centre Study

Conditions
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Radiotherapy

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: planned but not already commenced radiation therapy (RT) of the chest, with or without pre-RT surgery. signed informed consent of the participant Exclusion Criteria: thoracic RT in the past treatment with immune checkpoint inhibitors unstable condition affecting participation in the measurements

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in diffusing capacity for nitric oxide (DLNO) |  | Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diffusing capacity for carbon monoxide (DLCO) | The course over time will be described. | Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT | 
| Transfer Coefficient for nitric oxide (DLNO/VA) | The course over time will be described. | Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT | 
| Transfer Coefficient for carbon monoxide (DLCO/VA) | The course over time will be described. | Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT | 
| Ratio of DLNO and DLCO | The course over time will be described. | Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT | 
| Alveolar-capillary membrane-diffusing capacity for carbon monoxide (DMCO) | The course over time will be described. | Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT | 
| Pulmonary capillary blood volume (Vc) | This variable is a calculated variable. The course over time will be described. | Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT | 
| Alveolar Volume (VA) | This variable is a calculated variable. The course over time will be described. | Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT | 
| Fractional concentration of exhaled nitric oxide at a flow rate of 50mL/s (FENO50) | The course over time will be described. | Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT | 
| Concentration of nitric oxide in the gas phase of the alveolar or acinar region (CANO) | The course over time will be described. | Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT | 
| Tissue concentration of nitric oxide of the airway wall (CawNO) | The course over time will be described. | Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT | 
| Airway compartment diffusing capacity of nitric oxide from the of of the airway wall to the gas stream (DawNO) | The course over time will be described. | Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT | 
| Total flux of nitric oxide in the conducting airway compartment (JawNO) | The course over time will be described. | Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT | 
| Forced expiratory volume in 1 second | The course over time will be described. | Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT | 
| Forced vital capacity | The course over time will be described. | Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT | 
| Forced expiratory flow between 25% and 75% of forced vital capacity | The course over time will be described. | Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT |