Dairy Proteins and Postprandial Appetite Regulation and Energy Expenditure

Study Overview
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Brief Summary
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The aim of this study is to examine the effect of dairy proteins (whey and casein) on postprandial appetite regulation and energy expenditure.

Detailed Description
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Several studies have shown that a high protein intake is associated with a increased loss of body weight and body fat as compared to a diet with a normal or low protein content. The effect seems to be due to a higher diet induced thermogenesis and increase satiety. Milk has a high content of proteins. It contains two very different types of protein: whey and casein. Whey is a soluble protein whereas casein clots into the stomach, which delays its gastric emptying and thus probably results in a slower release of amino acids. It is therefore very likely that the two types of protein affect the thermogenesis and appetite regulation differently. The aim of the present study is to examine the effect of dairy proteins (whey and casein) on postprandial energy expenditure, substrate oxidation and appetite regulation. The study will have a cross-over design including four meals each including a test drink (milk, casein drink, whey drink or water).

Official Title
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Dairy Proteins and Postprandial Appetite Regulation and Energy Expenditure

Conditions
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Obesity

Intervention / Treatment
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* Dietary Supplement: dairy proteins


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: healthy males body mass index (BMI) 25-30 kg/m2 18-50 years weight stable Exclusion Criteria: smoker regular use of medicine elitist athletes participation in other intervention studies

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: milk<br>skim milk | Dietary Supplement: dairy proteins<br>* Protein drinks with 3.5% protein. The protein source will be whey, casein or whey and casein (20:80; normal content in the milk). In the arm with water no protein will be added.<br>|
| Experimental: casein drink<br> | Dietary Supplement: dairy proteins<br>* Protein drinks with 3.5% protein. The protein source will be whey, casein or whey and casein (20:80; normal content in the milk). In the arm with water no protein will be added.<br>|
| Experimental: whey drink<br> | Dietary Supplement: dairy proteins<br>* Protein drinks with 3.5% protein. The protein source will be whey, casein or whey and casein (20:80; normal content in the milk). In the arm with water no protein will be added.<br>|
| Sham Comparator: water<br> | Dietary Supplement: dairy proteins<br>* Protein drinks with 3.5% protein. The protein source will be whey, casein or whey and casein (20:80; normal content in the milk). In the arm with water no protein will be added.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Subjective appetite sensation |  | 5 hours | 
| Energy expenditure |  | 5 hours | 
| Substrate oxidation |  | 5 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Dairy proteins, Appetite regulation, Energy expenditure