Pain Perception of People Who Are Unable to Have Headache

Study Overview
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Brief Summary
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Headaches are extremely common illnesses with a combined lifetime prevalence of 90-99% in Europe. Despite this high prevalence, there are persons who have never, in their whole life, encountered a headache. The aim of the study is to identify factors that protect against headache by studying pain perception, muscle tenderness and pain tolerance in people who never have had a headache (headache resistant) versus non-resistant controls. The investigators hope to contribute with novelty to the current understanding of headache pathophysiology and development of more efficient treatment of headache. The investigator examining: Quantitative sensory testing (cold pain threshold and heat pain threshold), Muscle tenderness (total tenderness score) and cold pressor test (time in the water and pain rating). All tests are performed the same day, by one investigator who are blinded to the grouping of the participants.

Official Title
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Pain Perception, Headache Provocation and Multiomics of People Who Are Unable to Have Headache

Conditions
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Headache, Pain, Head, Muscle Tenderness, Healthy

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Headache resistant and non-resistant male participants from the Danish Blood Donor Study. Weight: 45 kg to 95 kg Exclusion Criteria: Daily consumption of any medication. Consumption of any medication less than 12 hours prior to the study day. Headache on the study day or 48 hours prior to the study day. Amnestic or clinical signs of hypertension (systolic blood pressure >150 mmHg and/or diastolic blood pressure >100 mmHg) or hypotension (systolic blood pressure <90 mmHg and/or diastolic blood pressure <50 mmHg). Any severe cardiovascular disease, including cerebrovascular illness. Amnestic or clinical signs of current mental illness. Amnestic or clinical signs of current substance or drug abuse. Amnestic or clinical signs of any illness the responsible doctor considers relevant for participation in the study.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Headache Resistant Participants<br>Male participants who have never had a headache. | |
| Non-Resistant Participants<br>Male participants who have experienced headache. Age matched. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quantitative Sensory Test: Cold Pain Threshold | Difference in Cold Pain Threshold (celcius) between cases and controls. | 3 hours | 
| Quantitative Sensory Test: Heat Pain Threshold | Difference in Heat Pain Threshold (celcius) between cases and controls. | 3 hours. | 
| Pericranial Muscle Tenderness: Total Tenderness Scores | Difference in Total Tenderness Score between cases and controls. 8 pericranial muscles are palpated by the investigator and the tenderness is rated by the participant on a scale of 0-3 where 0 is no tenderness and 3 is severe tenderness. | 3 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cold Pressor Test: Pain Tolerance | Difference in Cold Pressor Test Pain Tolerance (seconds) between cases and controls | 3 hours | 
| Cold Pressor Test: Pain Rating | Difference in Cold Pressor Test Pain Rating by Verbal Rating Scale (VRS) between cases and controls. The pain is rated by the participant on the Verbal Rating Scale from 0 - 10 where 0 is no pain and 10 is the most severe pain imaginable. | 3 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Headache, Healthy, Muscle Tenderness, quantitative sensory testing, cold pain threshold, heat pain threshold, Total Tenderness Score, Cold Pressor Test, Headache Resistant