Efficacy Evaluation of Triple up® Collagen Drink on Skin Condition

Study Overview
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Brief Summary
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To assess Triple up® Collagen Drink on skin condition improvement

Official Title
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Efficacy Evaluation of Triple up® Collagen Drink on Skin Condition

Conditions
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Skin Condition

Intervention / Treatment
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* Dietary Supplement: Testing product
* Dietary Supplement: Blank


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy adults aged above 20 years old Exclusion Criteria: Subject who is not willing to participate in this study. Patients with diseases of the skin, heart, liver, kidney, endocrine and other organs and patients with mental illness (according to medical history). Subjects who have known cosmetic, drug or food allergies, difficulty in digestive tract absorption or disorder. Female who is pregnant or nursing or planning to become pregnant during the course of the study. Received facial laser therapy, chemical peeling or UV overexposure in the past 4 weeks. Vegetarian Subjects who have large spots (area >3 square centimeter) or abnormal acne.

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Placebo drink<br> | Dietary Supplement: Blank<br>* consume 1 bottle (50 mL) per day for 28 days<br>* Other names: Placebo drink;|
| Experimental: Triple up® Collagen Drink<br> | Dietary Supplement: Testing product<br>* consume 1 bottle (50 mL) per day for 28 days<br>* Other names: Triple up® Collagen Drink;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The change of skin moisture | Corneometer® CM825 was utilized to measure skin moisture. Units: arbitrary Corneometer® units 0-120 | Change from Baseline skin moisture at 4 weeks | 
| The change of skin elasticity | Cutometer® dual MPA 580 was utilized to measure skin elasticity (parameter R2). Units: μm penetration depth into the probe opening, expressed as curves | Change from Baseline skin elasticity at 4 weeks | 
| The change of skin wrinkles | VISIA Complexion Analysis System was utilized to measure wrinkles. Units: arbitrary units | Change from Baseline skin wrinkles at 4 weeks | 
| The change of skin collagen density | DermaLab® USB - 20 MHz High Freq. Ultrasound probe was utilized to scan and analyze skin collagen density. Units: Intensity score | Change from Baseline skin collagen density at 4 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The change of skin texture | VISIA Complexion Analysis System was utilized to measure skin texture. Units: arbitrary units | Change from Baseline skin texture at 4 weeks | 
| The change of skin pores | VISIA Complexion Analysis System was utilized to measure skin pores. Units: arbitrary units | Change from Baseline skin pores at 4 weeks |