Use of PRF in Treatment of Dry Socket.

Study Overview
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Brief Summary
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The aim of the study is to evaluate the influence of PRF application in case of alveolar osteitis.

Detailed Description
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The main objective was to compare the effects of using two different methods in the treatment of dry socket (alveolar osteitis), which is a postoperative complication of dental extraction. The first was Nipas, applied, if dry socket was diagnosed following a tooth extraction. In case of subsequent extraction of homonymous tooth and reoccurrence of dry socket, patients were treated with application of PRF.

Official Title
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Evaluation of Platelet Rich Fibrin Use in the Treatment of Dry Socket.

Conditions
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Alveolar Osteitis

Intervention / Treatment
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* Procedure: PRF application
* Drug: Nipas application


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: no known medical history of abnormal platelet counts, patients with symmetric teeth qualified for extraction, Exclusion Criteria: patients treated previously for existing dry socket, patients allergic to acetylsalicylic acid , systemic diseases, pregnancy, lactation, drugs known to affect the number or function of platelets, abnormal platelet counts,

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: The first medicine was applied, if dry socket was diagnosed following a tooth extraction. In case of subsequent extraction of homonymous tooth in the same patient and reoccurrence of dry socket, patients were treated with PRF application.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: PRF application<br>Patients with alveolar osteitis in which PRF application was performed. | Procedure: PRF application<br>* PRF application into post-operative wound.<br>|
| Active Comparator: Aspirin application<br>Patients with alveolar osteitis in which Nipas was used. | Drug: Nipas application<br>* Nipas application into post-operative wound.<br>* Other names: Aspirin paste;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Intensity of pain vs. PRF and Nipas application | In order to evaluate the relationship between intensity of pain after application of PRF and Nipas, Numeric Rating Scale pain scale is used. NRS is a horizontal line with an eleven point numeric range. It is labeled from zero to ten, with zero being an example of someone with no pain and ten being the worst pain possible. The higher score means worse outcome in case of present study. | 24 hours | 
| Influence of treatment on bacteria levels in wounds | The second part of the study was dedicated to analyzing the number of bacteria in tooth extraction wounds. | 24 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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dry socket, PRF