Hemodynamics for Equi-MAC Anesthesia

Study Overview
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Brief Summary
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The aim of this study is to compare the peripheral perfusion index values produced by equi-MAC of sevoflurane and desflurane in patients undergoing single-agent inhalation anesthesia.

Detailed Description
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Ether derivative anesthetics, including sevoflurane and desflurane, have direct activity on vascular tissue and both are vasodilators. However, there has been no direct comparison of vasodilative effect between sevoflurane and desflurane in vivo in humans. Peripheral perfusion index derived from photoplethysmographic waveform reflects peripheral vasomotor tone. Therefore, the purpose of this study is to compare the peripheral perfusion index values produced by sevoflurane and desflurane at equipotent concentration in patients undergoing single-agent inhalation anesthesia.

Official Title
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Comparison of Vasodilative Effects Between Sevoflurane and Desflurane Using Peripheral Perfusion Index

Conditions
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Anesthesia

Intervention / Treatment
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* Drug: Sevoflurane
* Drug: Desflurane


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients aged between 19 and 65 yr patients with American Society of Anesthesiologists physical status classification I or II patients scheduled for elective arthroscopic knee surgery under general anesthesia patients obtaining written informed consent Exclusion Criteria: patients with a history of any disease associated with the autonomic nervous system patients receiving any medication affecting the sympathetic or parasympathetic nervous systems patients with cardiac arrhythmia, diabetes mellitus, and alcohol or drug abuse pregnant women

Ages Eligible for Study
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Minimum Age: 19 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Sevoflurane<br>Anesthesia is maintained with sevoflurane. | Drug: Sevoflurane<br>* End-tidal concentration of sevoflurane is maintained at age-corrected 1.0 minimum alveolar concentration throughout the study period.<br>* Other names: Sevorane;|
| Experimental: Desflurane<br>Anesthesia is maintained with desflurane. | Drug: Desflurane<br>* End-tidal concentration of desflurane is maintained at age-corrected 1.0 minimum alveolar concentration throughout the study period.<br>* Other names: Suprane;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| peripheral perfusion index | peripheral perfusion index value at a steady-state anesthesia of age-corrected 1.0 MAC | After a 30-min waiting period from the induction of anesthesia | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| mean arterial pressure | mean arterial pressure at a steady-state anesthesia of age-corrected 1.0 MAC | After a 30-min waiting period from the induction of anesthesia | 
| heart rate | heart rate at a steady-state anesthesia of age-corrected 1.0 MAC | After a 30-min waiting period from the induction of anesthesia |