Spinal Anesthesia and Peri-operative Opioid Consumption in Open Abdominal Prostatectomy

Study Overview
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Brief Summary
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Retrospective analysis to assess the impact of spinal anesthesia on peri-operative opioid consumption during open abdominal prostatectomy. The authors compare the group that had spinal anesthesia in combination with propofol sedation and a laryngeal mask to the second group that underwent the same procedure in general anesthesia with tracheal intubation.

Detailed Description
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Retrospective analysis to assess the impact of spinal anesthesia on peri-operative opioid consumption during open abdominal prostatectomy. The authors compare the group that had spinal anesthesia in combination with propofol sedation and a laryngeal mask to the second group that underwent the same procedure in general anesthesia with tracheal intubation. ...

Official Title
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Impact of Spinal Anesthesia on Peri-operative Opioid Consumption in Open Abdominal Prostatectomy- a Retrospective Analysis

Conditions
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Pain, Postoperative, Opioid Use, Analgesia

Intervention / Treatment
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* Procedure: Open abdominal prostatectomy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: elective, radical abdominal prostatectomy >18 years Exclusion Criteria: chronic pain therapy (e.g. out-of-hospital opioid therapy) laparoscopic approach

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Spinal anesthesia with propofol sedation<br>Patients receive spinal anesthesia for analgesia to undergo open abdominal prostatectomy. Ventilation is secured via a laryngeal mask under propofol sedation and no muscular blocking is necessary. | Procedure: Open abdominal prostatectomy<br>* Patients undergo standardized open abdominal prostatectomy.<br>|
| General anesthesia<br>General anesthesia is conducted with a combination of intravenous opioid (sufentanil) and neuromuscular blocking agent for open abdominal prostatectomy. Patients receive an induction bolus of propofol, undergo tracheal intubation and maintenance of sedation by sevoflurane. | Procedure: Open abdominal prostatectomy<br>* Patients undergo standardized open abdominal prostatectomy.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Post-operative opioid consumption | Consumption of piritramid [mg] in PACU. | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Intra-operative opioid consumption | Consumption of sufentanil [mg] during surgery. Piritramid is given if NRS score is > 3. | 1 day | 
| Pain maximum | Postoperative pain level measured with the highest score in numeric pain rating scale (NRS) | 1 day | 
| Postoperative recovery time | Time interval between postoperative tracheal extubation and the patient reaching fit-for-discharge criteria from the PACU to the ward. | 1 day | 
| PONV/Shivering | Occurence of post-operative nausea and vomiting or shivering in PACU. | 1 day |