Prevention Study in Adult Patients Suffering From Migraine Headaches

Study Overview
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Brief Summary
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Purpose of the study is to evaluate dose response relationship, efficacy, safety and tolerability of target doses of GSK1838262 compared to placebo in the prophylactic treatment of migraine headache. Once subjects complete the baseline and meet the randomization criteria, they will complete a 5-wk flexible titration period and then enter the 12 week maintenance period.

Detailed Description
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MPX111381 is a multicenter, randomized, double-blind, placebo-controlled, parallel group, flexible-dose evaluation of GSK1838262 1200 mg/day, 1800 mg/day, 2400 mg/day and 3000 mg/day compared with placebo in the prophylactic treatment of migraine headache. Subjects 18 years of age must have experienced at least three migraine headache attacks (with or without aura according to 2004 International Headache Society [IHS] criteria 1.1 and 1.2.1) per month during the 3 months prior to screening and at least four migraine headache days but less than 15 total headache days (migraine or non-migraine) per month during the 3 months prior to screening and must maintain this requirement throughout the last 4 weeks of the baseline period. Approximately 528 subjects from approximately 53 centers in North America will be randomized in a 2:1:2:2:1 ratio to the following treatment groups: placebo, GSK1838262 1200 mg/day, 1800 mg/day, 2400 mg/day and 3000 mg/day. Investigational product will be administered twice daily (morning and evening) with food (e.g., meal or snack). The study will consist of six study periods for a total study duration of up to 30 weeks: Screening (2 weeks), baseline (including randomization, 6 weeks), flexible titration (5 weeks), maintenance (12 weeks), taper (3 weeks) and post-treatment (2 weeks). The flexible titration administration of investigational product is designed to allow subjects to reach the target dose for maintenance treatment or, if unable to reach this target dose, to achieve a maximum tolerated dose for maintenance treatment. Subjects will have the opportunity to undergo a single dose (600 mg/day) downward adjustment during the flexible titration period if intolerability at the current dose occurs. Subsequently, if a single dose downward adjustment has occurred, no further dose adjustments in the study (upward or downward) will be permitted.

Official Title
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Study MPX111381: A Dose-ranging Study Evaluating the Efficacy, Safety and Tolerability of GSK1838262 (XP13512) in the Prophylactic Treatment of Migraine Headache

Conditions
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Migraine Disorders, Migraine

Intervention / Treatment
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* Drug: GSK1838262
* Drug: Placebo


Participation Criteria
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Eligibility Criteria
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Inclusion criteria: Outpatient subjects aged 18 years or older. Females of non-childbearing potential. If of child-bearing potential, is not lactating and has a negative pregnancy test 7 days prior to study treatment initiation and agrees to use one of the GlaxoSmithKline (GSK)-specified highly effective methods for avoiding pregnancy. Subjects suffering from migraine headache with or without aura, according to 2004 IHS criteria 1.1 and 1.2.1. Subject has had a history of migraine headache for at least one year, and the age of onset was prior to 50 years. Subject has consistent migraine headache over time (i.e., incidence and severity). Subject has had at least three migraine headache attacks per month during the 3 months prior to screening and maintains this requirement during the last 4 weeks of the baseline period Subject has had at least four migraine headache days but less than 15 total headache days (migraine or non-migraine) per month during the 3 months prior to screening and maintains this requirement during the last 4 weeks of the baseline period. Subject is able to distinguish migraine headache attacks as discrete from other headaches (i.e., tension-type headaches). Subject has the ability to read, comprehend and legibly and reliably record information in paper and electronic format as required by the protocol. Subject must be able to provide written informed consent prior to participation in the study. The contents and process of obtaining informed consent will be in accordance with all applicable regulatory requirements. Exclusion Criteria: Subject has a history of ergotamine, triptan, opioid, and/or combination pain medication use on >/=10 days per month on a regular basis for >/= 3 months. Subject has failed more than 2 adequate treatments of migraine prophylaxis -where failure is defined as a lack of efficacy with treatment duration of at least 8 weeks. Subject has history of simple analgesic use on >/=15 days per month for >/=3months. Subject is unable to discontinue prohibited medications during the 2-week screening period and throughout the duration of the study including beta-blockers, benzodiazepines, tricyclic antidepressants, calcium channel blockers, antiepileptic drugs, bupropion or serotonergic noradrenergic reuptake inhibitors (SNRIs). Subjects who have taken gabapentin or pregabalin previously for the prophylactic treatment of migraine headache. Subjects who have taken gabapentin or pregabalin for treatment of conditions other than migraine are eligible provided, (1) their total exposure to gabapentin and pregabalin is less than 3 months during the preceding 12 months, and (2) the subject stopped taking gabapentin or pregabalin for at least 3 months prior to baseline. Subject has a history of cluster headaches or basilar, ophthalmoplegic, hemiplegic, or transformed migraine headaches. Subject has a current or past history of seizure disorder. Subject has any of the following medical conditions, laboratory abnormalities or disorders: Hepatic impairment defined as alanine aminotransferase (ALT) or aspartate aminotransferase (AST) >2x upper limit of normal (ULN) or alkaline phosphatase or bilirubin >1.5x ULN Chronic hepatitis B or C with a positive Hepatitis B surface antigen (HBsAg) or Hepatitis C Core Antigen Antibody (Hep C antibody) Impaired renal function defined as either creatinine clearance <60 mL/min (estimation of creatinine clearance by Cockroft and Gault Method) or renal dysfunction requiring hemodialysis Corrected QT (QTc) interval >/= 450 msec based on the average QTc value of triplicate electrocardiograms (ECGs) obtained by the central ECG reader over a brief recording period QTc interval >/= 480 msec for subjects with Bundle Branch Block based on the average QTc value of triplicate ECGs obtained by the central ECG reader over a brief recording period Uncontrolled hypertension at screen or at time of randomization (sitting systolic blood pressure [SBP] >160 mmHg and/or sitting diastolic blood pressure [DBP] >90 mmHg) Medical condition or disorder that would interfere with the action, absorption, distribution, metabolism, or excretion of GSK1838262, or, in the investigator's judgement: Is considered to be clinically significant and may pose a safety concern, or, Could interfere with the accurate assessment of safety or efficacy, or, Could potentially affect a subject's safety or study outcome. Subject meets criteria as defined by the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) for a major depressive episode or for active significant psychiatric disorders within the past year, including dementia, general anxiety disorder, psychotic disorders or bipolar disorder. Subjects with a history of depression that is in remission, with or without antidepressant treatment, may participate, unless a stable antidepressant regimen includes a prohibited medication. Antidepressant medication may not be changed or discontinued to meet entry criteria and must be stable for at least 3 months prior to screening. Subject has a history of clinically significant drug or alcohol abuse as defined by DSM IV TR or is unable to refrain from substance abuse throughout the study. Subject is currently participating in another clinical study in which the subject is, or will be exposed to an investigational or non-investigational drug or device. Subject has participated in a clinical study in which the subject was exposed to an investigational or non investigational drug or device: Within the preceding month for studies unrelated to the current illness (migraine headaches), or Within the preceding 3 months for studies related to the current illness (migraine headaches). Subjects who have taken botulinum toxin type A (Botox) within the past 6 months. Subject has a history of an allergic reaction, or a medically significant adverse reaction to the investigational product or excipients, which, in the opinion of the investigator, makes a subject unsuitable for participation in the study. Subject is felt to be at risk of non-compliance (e.g., for taking investigational product or for completing the electronic diary [e-diary]), in the investigator's opinion. Subject is a pregnant or nursing woman.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Placebo<br>PBO | Drug: Placebo<br>* Placebo-control<br>|
| Active Comparator: GSK 1838262 1200 mg/day<br>600 or 1200 mg/day | Drug: GSK1838262<br>* Flexible dosing: 1200 mg/day, 1800 mg/day, 2400 mg/day and 3000 mg/day<br>* Other names: XP13512;|
| Active Comparator: GSK 1838262 1800 mg/day<br>600 or 1200 or 1800 mg/day | Drug: GSK1838262<br>* Flexible dosing: 1200 mg/day, 1800 mg/day, 2400 mg/day and 3000 mg/day<br>* Other names: XP13512;|
| Active Comparator: GSK 1838262 2400 mg/day<br>600 or 1200 or 1800 or 2400 mg/day | Drug: GSK1838262<br>* Flexible dosing: 1200 mg/day, 1800 mg/day, 2400 mg/day and 3000 mg/day<br>* Other names: XP13512;|
| Active Comparator: GSK 1838262 3000 mg/day<br>600 or 1200 or 1800 or 2400 or 3000 mg/day | Drug: GSK1838262<br>* Flexible dosing: 1200 mg/day, 1800 mg/day, 2400 mg/day and 3000 mg/day<br>* Other names: XP13512;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Adjusted Mean Change From Baseline in the Number of Migraine Headache Days (MHD) During the Last 4 Weeks of Treatment Prior to Taper | A migraine headache day is defined as a calendar day with any occurrence of migraine headache pain of at least 30 minutes in duration. Change from baseline was calculated as the mean number of MHD over the last 4 weeks of treatment prior to taper minus the number at baseline using the Last Observation Carried Forward (LOCF). The last 4-week treatment phase is based on the last 4 weeks prior to taper for each participant. | Baseline and last 4 weeks of treatment prior to taper (up to Week 17) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mean Change From Baseline in the Number of MHD in All Study Phases | A migraine headache day is defined as a calendar day with any occurrence of migraine headache pain of at least 30 minutes in duration. Change from baseline and the last 4 weeks of treatment prior to taper were calculated means of the number of migraine headache days using the Last Observation Carried Forward (LOCF). Change from baseline is calculated as post-baseline minus baseline. The last 4-week treatment phase is based on the last 4 weeks prior to taper for each participant. | Baseline and last 4 weeks of treatment prior to taper (up to Week 17) | 
| Adjusted Mean Change From Baseline in the Number of Migraine Attacks | A migraine attack is defined as a migraine headache of at least 30 minutes in duration and may also include recurring non-migraine or migraine headaches . Change from baseline and the last 4 weeks of treatment prior to taper were calculated means of the number of migraine attacks using the Last Observation Carried Forward (LOCF). The last 4-week treatment phase is based on the last 4 weeks prior to taper for each participant. | Baseline and last 4 weeks of treatment prior to taper (up to Week 17) | 
| Mean Change From Baseline in the Number of Migraine Headache Periods (MHP) | A migraine headache period is a 24-hour block of time that begins at the onset of a migraine event . The 24-hour period is not linked directly with a calendar day. The change from baseline and the last 4 weeks of treatment prior to taper were calculated means of the number of migraine headache periods using the Last Observation Carried Forward (LOCF). The last 4-week treatment phase is based on the last 4 weeks prior to taper for each participant. | Baseline and last 4 weeks of treatment prior to taper (up to Week 17) | 
| Change From Baseline in the Mean Migraine Attack Duration | The total duration of a migraine attack is measured from migraine attack onset until the resolution of the attack measured in hours and may include more than 1 headache event. The duration is assessed using a Daily Migraine Diary. Change from baseline and the last 4 weeks of treatment prior to taper were calculated means of the number of migraine headache days using the Last Observation Carried Forward (LOCF). Change from baseline is calculated as post-baseline minus baseline. The last 4-week treatment phase is based on the last 4 weeks prior to taper for each participant. | Baseline and last 4 weeks of treatment prior to taper (up to Week 17) | 
| Change From Baseline in the Mean Peak Migraine Pain Severity | Peak Migraine Pain Severity was measured using a 4-point scale (0=none, 1=mild, 2=moderate, or 3=severe) on a participant self assessed Daily Migraine Diary. The scale measured the maximum pain severity across all headache events considered to be one attack.. Change from baseline and the last 4 weeks of treatment prior to taper were calculated means of the number of migraine headache days using the Last Observation Carried Forward (LOCF). The last 4-week treatment phase is based on the last 4 weeks prior to taper for each participant. | Baseline and last 4 weeks of treatment prior to taper (up to Week 17) | 
| Mean Change From Baseline to the Last 4-Week Treatment Phase in the Number of Days of Acute Migraine Medication Use | The Number of Days of Acute Migraine Medication Use was assessed via the participant-assessed Daily Migraine Diary. | Baseline and last 4 weeks of treatment prior to taper (up to Week 17) | 
| Mean Change From Baseline to the Last 4-Week Treatment Phase in the Number of Acute Migraine Medication Doses Administered | The Number of Acute Migraine Medication Doses Administered was captured via the participant-assessed Daily Migraine Diary. | Baseline and last 4 weeks of treatment prior to taper (up to Week 17) | 
| Mean Change From Baseline to the Last 4-Week Treatment Phase in the Number of Acute Migraine Medication Doses Administered by Triptan Use | The Number of Acute Migraine Medication Administered was measured via the participant-assessed Daily Migraine Diary. | Baseline and last 4 weeks of treatment prior to taper (up to Week 17) | 
| Mean Change From Baseline to the Last 4-Week Treatment Phase in the Number of Acute Migraine Medication Doses Administered by Opioid Use | The Number of Acute Migraine Medication Doses Administered by Opioid Use was measured via the participant-assessed Daily Migraine Diary. | Baseline and last 4 weeks of treatment prior to taper (up to Week 17) | 
| Mean Change From Baseline to the Last 4-Week Treatment Phase in the Number of Acute Migraine Medication Doses Administered by Prescription Headache Medication Use | The Number of Acute Migraine Medication Doses Administered by Prescription Headache Medication use was measured via the participant-assessed Daily Migraine Diary. | Baseline and last 4 weeks of treatment prior to taper (up to Week 17) | 
| Mean Change From Baseline in Percentage of Migraine Attacks With Each of the Following Migraine Symptoms: Aura, Nausea, Vomiting, Photophobia, Phonophobia | The endpoint is defined as the percentage of attacks with each symptom (separately) for each study phase. Migraine symptoms aura, nausea, vomiting, photophobia, and phonophobia are defined as the presence of each migraine symptom during any of the headache events within an attack. | Baseline and last 4 weeks of treatment prior to taper (up to Week 17) | 
| Percentage of Participants Classified as Responders for Each of the Following Measures: Migraine Headache Days, Migraine Attacks, and Migraine Headache Periods | A responder is defined as a participant who achieved at least a 50% reduction from baseline for the indicated measures. | Baseline to the Last 4 weeks of treatment | 
| Number of Participants Who Were Much Improved or Very Much Improved on the 7-point Likert Patient Global Impression of Change (PGIC) Scale Using LOCF at Week 17 | The PGIC is a single question measured on the 7-point Likert Scale (1 = very much improved; 2 = much improved; 7 = very much worse). A responder is defined as being very much improved or much improved. | Week 17 | 
| Number of Participants Who Were Much Improved or Very Much Improved (Responders) on the 7-point Likert Clinical Global Impression of Change (CGIC) Scale Using LOCF at Week 17 | The CGIC is a single question measured on a 7-point Likert Scale. (1 = very much improved; 2= much improved, and 7 = very much worse) designed to give an assessment of treatment from a clinician's perspective. A responder is defined as being 'Very much improved' or 'much improved'. | Week 17 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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migraine, prophylaxis, prevention