Identification of Genetic Markers Modulating Rhythmic Risk Among Patients With Severe Cardiomyopathy

Study Overview
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Brief Summary
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The aim of this project is to identify common genetic polymorphisms associated with the occurrence of rhythmic events in patients with severe cardiomyopathy.

Official Title
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Identification of Genetic Markers Modulating Rhythmic Risk Among Patients With Severe Cardiomyopathy

Conditions
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Cardiomyopathy

Intervention / Treatment
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* Genetic: Identification of genetic polymorphisms


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients implanted for primary prevention, an implantable cardioverter defibrillator (ICD) single or double room, for severe cardiomyopathy (EF <35%) Patients with ischemic cardiomyopathy or idiopathic dilated cardiomyopathy.- Appropriate treatment group: patients who had a rhythmic event (before or after inclusion) appropriately treated either by administering an electric shock or by antiarrhythmic stimulation Group no event patients who have never received treatment or electrical antiarrhythmic stimulation and with a minimum follow-up of three years before inclusion and did not receive proper treatment during the follow up period of the study Exclusion Criteria: Patients implanted with an ICD for primary prevention in the context of a family hereditary disease (long QT syndrome, Brugada syndrome, hypertrophic cardiomyopathy, ventricular tachycardia catecholergic right ventricular dysplasia ...). Patients with left ventricular function greater than 35%. Patients implanted with a defibrillator function resynchronization. Patients minors, adults under guardianship and protected persons are eligible under this project.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Appropriate treatment<br>Patients who have a rhythmic event (before or after inclusion) appropriately treated either by administering an electric shock or by antiarrhythmic stimulation | Genetic: Identification of genetic polymorphisms<br> <br> |
| No event<br>Patients who have never received treatment or electrical antiarrhythmic stimulation and with a minimum follow-up of three years before inclusion and did not receive appropriate treatment during the follow up period of the study. | Genetic: Identification of genetic polymorphisms<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prevalence of polymorphisms pre-selected candidates (or by direct sequencing by High Resolution Melting). |  | 4 years | 
| Identification of polymorphisms frequent (> 5% in the general population) by association study ( Genome Wide Association Study '(GWAS)) using genotyping technology broadband Axiom (Affymetrix). |  | 4 years |