Magnetic Resonance (MR) Imaging to Determine High Risk Areas in Patients With Malignant Gliomas and to Design Potential Radiation Plans and to Examine Metabolite Changes in Gliomas and Other Solid Tumors

Study Overview
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Brief Summary
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The researchers think that the use of advanced MR imaging may help people with this disease, because it may better predict areas within a malignant glioma (brain tumor) that are at a high risk of recurring. WeThe reserchers are doing this study to see whether this advanced imaging is a safe treatment that causes few or mild side effects in people with brain tumors.

Official Title
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Using Advanced MR Imaging to Determine High Risk Areas in Patients With Malignant Gliomas and to Design Potential Radiation Plans: A Pilot Study, and to Examine Metabolite Changes in Gliomas and Other Solid Tumors

Conditions
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Brain Cancer, Glioma

Intervention / Treatment
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* Procedure: MRI and advanced MRI sequences


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Suspected or Histopathologically proven diagnosis of high grade or low glioma or tumor is suspected to harbor an isocitrate dehydrogenase (IDH) mutation May undergo radiation therapy Patient and/or guardian is able to provide written informed consent prior to study registration Age ≥ 18 years old Exclusion Criteria: Extreme claustrophobia that precludes MRI scan Known allergic reaction to Gd-DTPA Any contraindication to gadolinium intravenous contrast as per standard Department of Radiology contrast guidelines Any absolute contraindication to MRI (e.g., pacemaker, aneurysm clip, tissue expander). Pregnant or nursing female Unable to cooperate for MRI and/or radiation therapy planning

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: MRI<br>The advanced MRI studies will be obtained at the time of the routinely scheduled preoperative planning MRI and/or the routinely scheduled pre-RT planning MRI at approximately 3±2 weeks after surgery. The routine sequences obtained for the planning MRI are standard of care. The advanced MRI sequences may or may not be additional as some have already been adopted into the standard of care imaging at MSKCC. | Procedure: MRI and advanced MRI sequences<br>* This is a nonrandomized study in which each patient will receive the standard clinical care (in the form of surgery, radiation therapy and/or chemotherapy), as per the treating physician. Surgical resection will be performed at the discretion of the treating Neurooncologist and/or Neurooncology Tumor Board. Advanced brain MRIs with the 2 (or, in some cases, 3) special sequences will be obtained at the time of the clinically scheduled contrast MRIs, which are usually obtained immediately prior to and 1 months±3 weeks after radiation therapy if the patient requires radiation therapy for his/her tumor. The advanced brain MRI may also be obtained before surgery for suspected or confirmed gliomas, as per the standard of care, in some patients who may or may not require radiation therapy.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To assess the utility of baseline advanced MRI & changes between baseline & follow up advanced MRI in predicting high risk areas that are likely to develop progressive glioma despite chemoradiotherapy. |  | 1 -7 weeks before radiation treatment, about two months after treatment, and about every two months thereafter for the duration of the study. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To compare radiation therapy simulations in patients with gliomas using conventional and baseline advanced MRI data. |  | prior to and 1 months±3 weeks after radiation therapy. | 
| feasibility of 2HG spectroscopy |  | 2 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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MRI, brain tumor, radiation, 09-009