Impact of Steroid, Diuretic, and Fluid Use on BPD Outcomes

Study Overview
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Brief Summary
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Assess the impact of steroid, diuretic, and fluid practices on BPD outcomes in extreme premature infants in the Banner - University Medical Center Phoenix (BUMCP) neonatal intensive care unit (NICU).

Detailed Description
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The investigators propose performing a retrospective analysis of the current respiratory management methods to potentially find a correlation between the number of steroid doses administered, the timing of initiation of steroid therapy and the effect on premature infants at risk for developing BPD. The investigators are also going to explore the number and timing of diuretic medications and average fluid intake.

Official Title
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A Retrospective Chart Review Evaluating the Impact of Steroid, Diuretic, and Fluid Use Practice Trends in Extreme Premature Infants at Risk for Bronchopulmonary Dysplasia (BPD) at a Single Center Neonatal Intensive Care Unit

Conditions
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BPD - Bronchopulmonary Dysplasia

Intervention / Treatment
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* Other: No interventions or procedures


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Infants born at <30 weeks and/or <1500g Admitted to BUMCP between January 1, 2019 and December 31, 2020 Exclusion Criteria: Infants that do not survive to 36 weeks CGA, when the determination of BPD is made Infants that are transferred to another hospital prior to 36 weeks CGA Out born infants Infants with life threatening congenital anomalies Investigator discretion as to other factors which might impact the study
Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Inclusion Group<br>Infants born at <30 weeks and/or <1500g that were admitted to BUMCP between January 1, 2019 and December 31, 2020 | Other: No interventions or procedures<br>* This is a retrospective observational study and data will be collected from the subject's existing medical record. No interventions or procedures will be required for this study.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To assess the impact of steroid practices on BPD outcomes in these infants | - The incidence of BPD stratified into three stages based on the type of support required at 36 weeks CGA | 30 days | 
| To assess the impact of steroid practices on BPD outcomes in these infants | - Presence of prenatal steroid administration | 30 days | 
| To assess the impact of steroid practices on BPD outcomes in these infants | - Administration of steroids to the infant | 30 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To determine if steroid use has an impact on infant growth | - Collect growth and calculate the z-score at five intervals | 30 days | 
| To determine if steroid use has an impact on NICU length of stay (LOS) | - NICU LOS in days | 30 days |