Effect of Oral Water in Healthy Volunteers on Cardiac Output, Regional Flow and Microcirculation in Healthy Volunteers

Study Overview
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Brief Summary
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Human digestive system physiologically ensures the absorption of oral water and hydration of the human body. Water is quickly absorbed by the digestive tract with a peak between 15 and 20 minutes. It has demonstrated that oral water remains the best hydration solution that have an effect on plasma volume expansion and cardiovascular system during exercise. While the cardiovascular effect of fluid expansion by saline serum is well known (venous return, preload and cardiac output), effect of oral water varies in the literature depending on the physiological state of the patient and the clinical state. Thus, the investigators aim to investigate oral water effects on fluid responsiveness, regional blood flow and microcirculatory changes.

Official Title
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Effect of Oral Water in Healthy Volunteers on Cardiac Output, Regional Flow and Microcirculation in Healthy Volunteers

Conditions
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Intravenous Fluids, Pharmacodynamics, Fluid Therapy, Fluid Responsiveness, Fluid Challenge

Intervention / Treatment
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* Other: saline intravenous administration
* Other: oral water


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy volunteer subject between 18 and 30 years old patient with a regular sinus rhythm Echogenic subject. Fasting of solid and liquid since 8 h Subject in regular sinus rhythm. Written consent signed. Exclusion Criteria: Any known cardiac, renal or endocrine pathology. Arrhythmia rhythm disorder by atrial fibrillation Pregnant or nursing woman. Pathology versus indicating Nacl administration. Person under tutors or curators or deprived of liberty. Person not affiliated to a social security scheme.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 30 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: oral water<br>Experimental group: oral administration of 500 ml of water. | Other: oral water<br>* 500 ml oral water<br>|
| Active Comparator: intravenous<br>Active comparator: Administration of 500 mL of saline (NaCl 0.9%) administered by the venous route | Other: saline intravenous administration<br>* Administration of 500 mL of saline (NaCl 0.9%) administered by the venous route<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| number of fluid responders 30 minutes after fluid expansion |  | 30 minutes after fluid expansion | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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intravenous fluids, pharmacodynamics, fluid therapy, fluid responsiveness, fluid challenge