Computer-based Training of Face Recollection to Improve Face Recognition in Developmental Prosopagnosia

Study Overview
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Brief Summary
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This study will examine the effectiveness of a cognitive training intervention targeting face recollection, repetition lag training, at improving face recognition in Developmental Prosopagnosia.

Official Title
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Characterizing and Remediating Recollection-specific Face Recognition Deficits in Developmental Prosopagnosia

Conditions
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Developmental Prosopagnosia

Intervention / Treatment
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* Behavioral: cognitive training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Developmental prosopagnosic participants will be included if they are... aged 18-90, have lifelong histories of face recognition difficulties that impact their everyday life (i.e., not associated with some event such as a stroke, seizure, etc) score significantly below the mean on the famous faces test and Cambridge Face Memory Test Exclusion Criteria: Participants will be excluded from the study if they... have a history of a significant neurological disorder including hydrocephalus, stroke, moderate to severe traumatic brain injury (TBI), severe neuromuscular diseases, or severe hypoxia due to cardiac arrest. have impairments that interfere with cognitive performance, such as uncorrected hearing or vision, lack of English proficiency, musculoskeletal or other issues have psychiatric disorders, such as schizophrenia, major depressive disorder, bipolar disorder, chronic intractable obsessive-compulsive disorder, or agoraphobia. We will exclude individuals who are currently dependent on alcohol or other substances, as this may negatively impact cognitive performance. We will exclude participants who currently are, or within the last 6 months, participating in a behavioral or pharmacological intervention. Patients with a history of mild TBI or simple concussion will not be excluded as long as it was > 6 months ago and as long as they have not had repeated concussions (>5) We will include individuals with a diagnosis of ADHD as long as their medication has been consistent for the past 6 months.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: holistic face training + repetition lag training<br> | Behavioral: cognitive training<br>* training to improve encoding and recognition of faces<br>|
| No Intervention: waitlist control<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cambridge Face Memory Test | learning and recognizing novel faces, out of 72 (higher score is better) | 15 minutes | 
| Face Recollection | old/new face recognition test, extracting familiarity and recollection parameters, higher score is better | 15 minutes | 
| Face Perception | composite of face matching tasks, Cambridge Face perception Test and computerized Benton, higher score is better | 30 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Self-reported face recognition | questionnaire | 5 minutes | 
| Face-name learning task |  | 15 minutes |