Effect of Exercise on GDF-15 Levels in Prediabetic Patients

Study Overview
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Brief Summary
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The aim of this study is to evaluate whether there is a change in GDF-15 levels in individuals with prediabetes at the 2nd hour after the first exercise and after a 12-week exercise program with guide-based exercise programs.

Detailed Description
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GDF-15, which has anorexigenic effects, increases with exercise. In prediabetic patients, GDF-15 is higher than healthy controls. The effect of exercise on GDF-15 levels in prediabetic patients is unknown. The aim of this study is to evaluate whether there is a change in GDF-15 levels after the application of guideline-based exercise programs in individuals with prediabetes at the 2nd hour after the first exercise and after a 12-week exercise program.

Official Title
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Effect of Exercise on GDF-15 Levels in Prediabetic Patients

Conditions
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PreDiabetes

Intervention / Treatment
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* Behavioral: Exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Body mass index 30-34.9 kg / m2 Sedentary life-style (Physical activity below 300 kcal / day will be assessed by Minnesota Leisure Physical Activity Questionnaire) Those who have sufficient motivation to participate in the exercise program (will be evaluated by face-to-face interview by the researchers) Having the same weight for 6 months before participating in the study (± 2.5 kg) Those diagnosed with prediabetes by oral glucose tolerance test and / or HbA1c measurement will be included. Exclusion Criteria: Serious medical condition (e.g. advanced malignancy or major neurological, psychiatric or endocrine disease, respiratory failure, etc.) Having cardiovascular disease Having diabetes Using metformin Taking hormone replacement therapy less than 1 year life expectancy HIV positivity Substance use Functional dependence Cognitive weakness Those with other diseases that will affect the study result (respiratory diseases, muscle diseases, etc.) Those who use drugs or supplements that will affect the results of the study

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Exercise intervention will be applied to intervention group All participiants will be applied to standard recommendations
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: İntevention group<br>Prediabetic patients with age 30-50 and overweight Standart recommendations Exercise intervention will be made. | Behavioral: Exercise<br>* 180 minutes of moderate-intensity exercise per week<br>|
| No Intervention: Control group<br>Prediabetic patients with age 30-50 and overweight Only Standart recommendations | |
| No Intervention: Metformin Group<br>Prediabetic patients who received metformin Standart recommendations | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Level of Growth Diferantiation Factor-15 | Level of Growth Diferantiation Factor-15 | 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Level of VO2max | Level of VO2max | 12 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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GDF-15, Physical Exercise, Prediabetes