Evaluation of Oxygen Consumption and Energy Expenditure During Spontaneous Breathing Trial.

Study Overview
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Brief Summary
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The purpose of this study is to compare the oxygen consumption and energy expenditure during the spontaneous breathing trial.

Detailed Description
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Patients is going to submit to the 2 spontaneous breathing trial ( Automatic tube compensation plus continuous positive airway pressure and continuous positive airway pressure without automatic tube compensation. The oxygen consumption and energy expenditure is going to measure during the spontaneous breathing trial by indirect calorimetry.

Official Title
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Evaluation of Oxygen Consumption and Energy Expenditure During Spontaneous Breathing Trial - A Randomized Crossover Controled Trial.

Conditions
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Respiratory Failure

Intervention / Treatment
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* Device: Automatic Tube Compensation plus CPAP
* Device: Continuous Positive Airway Pressure


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: IMPROVEMENT OR RESOLUTION OF THE UNDERLYING CAUSE OF DISEASE INTUBATED PATIENTS>24h PaO2 GREATER THAN 60 mmHg WITH FiO2 LESS THAN 40% PEEP=5 cmH2O Exclusion Criteria: CARDIOVASCULAR INSTABILITY FEBRILE OR HYPOTHERMIA CHEST DRAINAGE RESPIRATORY RATE/TIDAL VOLUME RATIO GREATER THAN 105 PREGNANCY FAIL IN THE SPONTANEOUS BREATHING TRIAL LEAKS IN THE CIRCUIT AGITATION NOT ACCEPT PARTICIPATE IN THE STUDY

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Automatic tube compensation plus CPAP<br>The patients is going to undergo trials of spontaneous breathing with automatic tube compensation plus continuous positive airway pressure and later a trial with continuous positive airway pressure. During 30 minutes. | Device: Automatic Tube Compensation plus CPAP<br>* SPONTANEOUS BREATHING TRIAL WITH AUTOMATIC TUBE COMPENSATION plus CPAP<br>* Other names: ATC+CPAP;Device: Continuous Positive Airway Pressure<br>* SPONTANEOUS BREATHING TRIAL WITH CPAP<br>|
| Active Comparator: Continuous Positive Airway Pressure<br>The patients is going to undergo a trial of spontaneous breathing with continuous positive airway pressure and later with automatic tube compensation plus continuous positive airway pressure, during 30 minutes each. | Device: Automatic Tube Compensation plus CPAP<br>* SPONTANEOUS BREATHING TRIAL WITH AUTOMATIC TUBE COMPENSATION plus CPAP<br>* Other names: ATC+CPAP;Device: Continuous Positive Airway Pressure<br>* SPONTANEOUS BREATHING TRIAL WITH CPAP<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measurement of oxygen consumption through indirect calorimetry. | Measurements using indirect calorimetry for determination of oxygen consumption | The measurement is during the spontaneous breathing trial, 30 minutes. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measurement of energy expenditure through indirect calorimetry | Measurement using indirect calorimetry for determination of energy expenditure. | The measurement is during the spontaneous breathing trial, 30 minutes. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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INDIRECT CALORIMETRY, MECHANICAL VENTILATION, WEANING VENTILATOR, AUTOMATIC TUBE COMPENSATION